Search of human proteins with 22550104

Search of human proteins with 22550104

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|22550104 ubiquitin specific protease 32 [Homo sapiens]
         (1604 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|22550104 ubiquitin specific protease 32 [Homo sapiens]            3303   0.0  
gi|109638751 ubiquitin specific protease 6 [Homo sapiens]            1753   0.0  
gi|239751420 PREDICTED: similar to hCG2039376 [Homo sapiens]         1343   0.0  
gi|24234683 ubiquitin specific peptidase 11 [Homo sapiens]            292   2e-78
gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens]    290   6e-78
gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens]            289   1e-77
gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens]    276   9e-74
gi|57529246 ubiquitin thioesterase 19 [Homo sapiens]                  199   2e-50
gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens]            166   1e-40
gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens]            166   1e-40
gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens]            166   1e-40
gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens]   152   3e-36
gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo sapi...   152   3e-36
gi|62243586 ubiquitin-specific protease 21 [Homo sapiens]             118   5e-26
gi|74027267 ubiquitin-specific protease 21 [Homo sapiens]             118   5e-26
gi|148612811 ubiquitin specific protease 43 [Homo sapiens]            113   1e-24
gi|120587027 ubiquitin specific peptidase 31 [Homo sapiens]           103   1e-21
gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens]                   97   2e-19
gi|45267835 ubiquitin specific protease 50 [Homo sapiens]              91   7e-18
gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens]                 90   2e-17
gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens]    87   1e-16
gi|42516567 ubiquitin specific protease 33 isoform 1 [Homo sapiens]    87   1e-16
gi|42516565 ubiquitin specific protease 33 isoform 2 [Homo sapiens]    87   1e-16
gi|183396780 ubiquitin specific protease 20 [Homo sapiens]             87   1e-16
gi|183397136 ubiquitin specific protease 20 [Homo sapiens]             87   1e-16
gi|183397134 ubiquitin specific protease 20 [Homo sapiens]             87   1e-16
gi|50312664 ubiquitin specific protease 16 isoform b [Homo sapiens]    87   2e-16
gi|5454156 ubiquitin specific protease 16 isoform a [Homo sapiens]     86   2e-16
gi|75992941 ubiquitin specific protease 16 isoform a [Homo sapiens]    86   2e-16
gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens]         79   3e-14

>gi|22550104 ubiquitin specific protease 32 [Homo sapiens]
          Length = 1604

 Score = 3303 bits (8563), Expect = 0.0
 Identities = 1604/1604 (100%), Positives = 1604/1604 (100%)

Query: 1    MGAKESRIGFLSYEEALRRVTDVELKRLKDAFKRTCGLSYYMGQHCFIREVLGDGVPPKV 60
            MGAKESRIGFLSYEEALRRVTDVELKRLKDAFKRTCGLSYYMGQHCFIREVLGDGVPPKV
Sbjct: 1    MGAKESRIGFLSYEEALRRVTDVELKRLKDAFKRTCGLSYYMGQHCFIREVLGDGVPPKV 60

Query: 61   AEVIYCSFGGTSKGLHFNNLIVGLVLLTRGKDEEKAKYIFSLFSSESGNYVIREEMERML 120
            AEVIYCSFGGTSKGLHFNNLIVGLVLLTRGKDEEKAKYIFSLFSSESGNYVIREEMERML
Sbjct: 61   AEVIYCSFGGTSKGLHFNNLIVGLVLLTRGKDEEKAKYIFSLFSSESGNYVIREEMERML 120

Query: 121  HVVDGKVPDTLRKCFSEGEKVNYEKFRNWLFLNKDAFTFSRWLLSGGVYVTLTDDSDTPT 180
            HVVDGKVPDTLRKCFSEGEKVNYEKFRNWLFLNKDAFTFSRWLLSGGVYVTLTDDSDTPT
Sbjct: 121  HVVDGKVPDTLRKCFSEGEKVNYEKFRNWLFLNKDAFTFSRWLLSGGVYVTLTDDSDTPT 180

Query: 181  FYQTLAGVTHLEESDIIDLEKRYWLLKAQSRTGRFDLETFGPLVSPPIRPSLSEGLFNAF 240
            FYQTLAGVTHLEESDIIDLEKRYWLLKAQSRTGRFDLETFGPLVSPPIRPSLSEGLFNAF
Sbjct: 181  FYQTLAGVTHLEESDIIDLEKRYWLLKAQSRTGRFDLETFGPLVSPPIRPSLSEGLFNAF 240

Query: 241  DENRDNHIDFKEISCGLSACCRGPLAERQKFCFKVFDVDRDGVLSRVELRDMVVALLEVW 300
            DENRDNHIDFKEISCGLSACCRGPLAERQKFCFKVFDVDRDGVLSRVELRDMVVALLEVW
Sbjct: 241  DENRDNHIDFKEISCGLSACCRGPLAERQKFCFKVFDVDRDGVLSRVELRDMVVALLEVW 300

Query: 301  KDNRTDDIPELHMDLSDIVEGILNAHDTTKMGHLTLEDYQIWSVKNVLANEFLNLLFQVC 360
            KDNRTDDIPELHMDLSDIVEGILNAHDTTKMGHLTLEDYQIWSVKNVLANEFLNLLFQVC
Sbjct: 301  KDNRTDDIPELHMDLSDIVEGILNAHDTTKMGHLTLEDYQIWSVKNVLANEFLNLLFQVC 360

Query: 361  HIVLGLRPATPEEEGQIIRGWLERESRYGLQAGHNWFIISMQWWQQWKEYVKYDANPVVI 420
            HIVLGLRPATPEEEGQIIRGWLERESRYGLQAGHNWFIISMQWWQQWKEYVKYDANPVVI
Sbjct: 361  HIVLGLRPATPEEEGQIIRGWLERESRYGLQAGHNWFIISMQWWQQWKEYVKYDANPVVI 420

Query: 421  EPSSVLNGGKYSFGTAAHPMEQVEDRIGSSLSYVNTTEEKFSDNISTASEASETAGSGFL 480
            EPSSVLNGGKYSFGTAAHPMEQVEDRIGSSLSYVNTTEEKFSDNISTASEASETAGSGFL
Sbjct: 421  EPSSVLNGGKYSFGTAAHPMEQVEDRIGSSLSYVNTTEEKFSDNISTASEASETAGSGFL 480

Query: 481  YSATPGADVCFARQHNTSDNNNQCLLGANGNILLHLNPQKPGAIDNQPLVTQEPVKATSL 540
            YSATPGADVCFARQHNTSDNNNQCLLGANGNILLHLNPQKPGAIDNQPLVTQEPVKATSL
Sbjct: 481  YSATPGADVCFARQHNTSDNNNQCLLGANGNILLHLNPQKPGAIDNQPLVTQEPVKATSL 540

Query: 541  TLEGGRLKRTPQLIHGRDYEMVPEPVWRALYHWYGANLALPRPVIKNSKTDIPELELFPR 600
            TLEGGRLKRTPQLIHGRDYEMVPEPVWRALYHWYGANLALPRPVIKNSKTDIPELELFPR
Sbjct: 541  TLEGGRLKRTPQLIHGRDYEMVPEPVWRALYHWYGANLALPRPVIKNSKTDIPELELFPR 600

Query: 601  YLLFLRQQPATRTQQSNIWVNMGNVPSPNAPLKRVLAYTGCFSRMQTIKEIHEYLSQRLR 660
            YLLFLRQQPATRTQQSNIWVNMGNVPSPNAPLKRVLAYTGCFSRMQTIKEIHEYLSQRLR
Sbjct: 601  YLLFLRQQPATRTQQSNIWVNMGNVPSPNAPLKRVLAYTGCFSRMQTIKEIHEYLSQRLR 660

Query: 661  IKEEDMRLWLYNSENYLTLLDDEDHKLEYLKIQDEQHLVIEVRNKDMSWPEEMSFIANSS 720
            IKEEDMRLWLYNSENYLTLLDDEDHKLEYLKIQDEQHLVIEVRNKDMSWPEEMSFIANSS
Sbjct: 661  IKEEDMRLWLYNSENYLTLLDDEDHKLEYLKIQDEQHLVIEVRNKDMSWPEEMSFIANSS 720

Query: 721  KIDRHKVPTEKGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMK 780
            KIDRHKVPTEKGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMK
Sbjct: 721  KIDRHKVPTEKGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMK 780

Query: 781  GHMAKCYGDLVQELWSGTQKNVAPLKLRWTIAKYAPRFNGFQQQDSQELLAFLLDGLHED 840
            GHMAKCYGDLVQELWSGTQKNVAPLKLRWTIAKYAPRFNGFQQQDSQELLAFLLDGLHED
Sbjct: 781  GHMAKCYGDLVQELWSGTQKNVAPLKLRWTIAKYAPRFNGFQQQDSQELLAFLLDGLHED 840

Query: 841  LNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIVVDLFHGQLRSQVKCKTCGHIS 900
            LNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIVVDLFHGQLRSQVKCKTCGHIS
Sbjct: 841  LNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIVVDLFHGQLRSQVKCKTCGHIS 900

Query: 901  VRFDPFNFLSLPLPMDSYMHLEITVIKLDGTTPVRYGLRLNMDEKYTGLKKQLSDLCGLN 960
            VRFDPFNFLSLPLPMDSYMHLEITVIKLDGTTPVRYGLRLNMDEKYTGLKKQLSDLCGLN
Sbjct: 901  VRFDPFNFLSLPLPMDSYMHLEITVIKLDGTTPVRYGLRLNMDEKYTGLKKQLSDLCGLN 960

Query: 961  SEQILLAEVHGSNIKNFPQDNQKVRLSVSGFLCAFEIPVPVSPISASSPTQTDFSSSPST 1020
            SEQILLAEVHGSNIKNFPQDNQKVRLSVSGFLCAFEIPVPVSPISASSPTQTDFSSSPST
Sbjct: 961  SEQILLAEVHGSNIKNFPQDNQKVRLSVSGFLCAFEIPVPVSPISASSPTQTDFSSSPST 1020

Query: 1021 NEMFTLTTNGDLPRPIFIPNGMPNTVVPCGTEKNFTNGMVNGHMPSLPDSPFTGYIIAVH 1080
            NEMFTLTTNGDLPRPIFIPNGMPNTVVPCGTEKNFTNGMVNGHMPSLPDSPFTGYIIAVH
Sbjct: 1021 NEMFTLTTNGDLPRPIFIPNGMPNTVVPCGTEKNFTNGMVNGHMPSLPDSPFTGYIIAVH 1080

Query: 1081 RKMMRTELYFLSSQKNRPSLFGMPLIVPCTVHTRKKDLYDAVWIQVSRLASPLPPQEASN 1140
            RKMMRTELYFLSSQKNRPSLFGMPLIVPCTVHTRKKDLYDAVWIQVSRLASPLPPQEASN
Sbjct: 1081 RKMMRTELYFLSSQKNRPSLFGMPLIVPCTVHTRKKDLYDAVWIQVSRLASPLPPQEASN 1140

Query: 1141 HAQDCDDSMGYQYPFTLRVVQKDGNSCAWCPWYRFCRGCKIDCGEDRAFIGNAYIAVDWD 1200
            HAQDCDDSMGYQYPFTLRVVQKDGNSCAWCPWYRFCRGCKIDCGEDRAFIGNAYIAVDWD
Sbjct: 1141 HAQDCDDSMGYQYPFTLRVVQKDGNSCAWCPWYRFCRGCKIDCGEDRAFIGNAYIAVDWD 1200

Query: 1201 PTALHLRYQTSQERVVDEHESVEQSRRAQAEPINLDSCLRAFTSEEELGENEMYYCSKCK 1260
            PTALHLRYQTSQERVVDEHESVEQSRRAQAEPINLDSCLRAFTSEEELGENEMYYCSKCK
Sbjct: 1201 PTALHLRYQTSQERVVDEHESVEQSRRAQAEPINLDSCLRAFTSEEELGENEMYYCSKCK 1260

Query: 1261 THCLATKKLDLWRLPPILIIHLKRFQFVNGRWIKSQKIVKFPRESFDPSAFLVPRDPALC 1320
            THCLATKKLDLWRLPPILIIHLKRFQFVNGRWIKSQKIVKFPRESFDPSAFLVPRDPALC
Sbjct: 1261 THCLATKKLDLWRLPPILIIHLKRFQFVNGRWIKSQKIVKFPRESFDPSAFLVPRDPALC 1320

Query: 1321 QHKPLTPQGDELSEPRILAREVKKVDAQSSAGEEDVLLSKSPSSLSANIISSPKGSPSSS 1380
            QHKPLTPQGDELSEPRILAREVKKVDAQSSAGEEDVLLSKSPSSLSANIISSPKGSPSSS
Sbjct: 1321 QHKPLTPQGDELSEPRILAREVKKVDAQSSAGEEDVLLSKSPSSLSANIISSPKGSPSSS 1380

Query: 1381 RKSGTSCPSSKNSSPNSSPRTLGRSKGRLRLPQIGSKNKLSSSKENLDASKENGAGQICE 1440
            RKSGTSCPSSKNSSPNSSPRTLGRSKGRLRLPQIGSKNKLSSSKENLDASKENGAGQICE
Sbjct: 1381 RKSGTSCPSSKNSSPNSSPRTLGRSKGRLRLPQIGSKNKLSSSKENLDASKENGAGQICE 1440

Query: 1441 LADALSRGHVLGGSQPELVTPQDHEVALANGFLYEHEACGNGYSNGQLGNHSEEDSTDDQ 1500
            LADALSRGHVLGGSQPELVTPQDHEVALANGFLYEHEACGNGYSNGQLGNHSEEDSTDDQ
Sbjct: 1441 LADALSRGHVLGGSQPELVTPQDHEVALANGFLYEHEACGNGYSNGQLGNHSEEDSTDDQ 1500

Query: 1501 REDTRIKPIYNLYAISCHSGILGGGHYVTYAKNPNCKWYCYNDSSCKELHPDEIDTDSAY 1560
            REDTRIKPIYNLYAISCHSGILGGGHYVTYAKNPNCKWYCYNDSSCKELHPDEIDTDSAY
Sbjct: 1501 REDTRIKPIYNLYAISCHSGILGGGHYVTYAKNPNCKWYCYNDSSCKELHPDEIDTDSAY 1560

Query: 1561 ILFYEQQGIDYAQFLPKTDGKKMADTSSMDEDFESDYKKYCVLQ 1604
            ILFYEQQGIDYAQFLPKTDGKKMADTSSMDEDFESDYKKYCVLQ
Sbjct: 1561 ILFYEQQGIDYAQFLPKTDGKKMADTSSMDEDFESDYKKYCVLQ 1604


>gi|109638751 ubiquitin specific protease 6 [Homo sapiens]
          Length = 1406

 Score = 1753 bits (4541), Expect = 0.0
 Identities = 853/908 (93%), Positives = 874/908 (96%), Gaps = 4/908 (0%)

Query: 701  EVRNKDMSWPEEMSFIANSSKIDRHKVPTEKGATGLSNLGNTCFMNSSIQCVSNTQPLTQ 760
            EV NKDMSWPEEMSF ANSSKIDR KVPTEKGATGLSNLGNTCFMNSSIQCVSNTQPLTQ
Sbjct: 499  EVHNKDMSWPEEMSFTANSSKIDRQKVPTEKGATGLSNLGNTCFMNSSIQCVSNTQPLTQ 558

Query: 761  YFISGRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGTQKNVAPLKLRWTIAKYAPRFNG 820
            YFISGRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGTQK+VAPLKLR TIAKYAP+F+G
Sbjct: 559  YFISGRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGTQKSVAPLKLRRTIAKYAPKFDG 618

Query: 821  FQQQDSQELLAFLLDGLHEDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIVV 880
            FQQQDSQELLAFLLDGLHEDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRSI+V
Sbjct: 619  FQQQDSQELLAFLLDGLHEDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIIV 678

Query: 881  DLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSYMHLEITVIKLDGTTPVRYGLRL 940
            DLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSYM LEITVIKLDGTTPVRYGLRL
Sbjct: 679  DLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSYMDLEITVIKLDGTTPVRYGLRL 738

Query: 941  NMDEKYTGLKKQLSDLCGLNSEQILLAEVHGSNIKNFPQDNQKVRLSVSGFLCAFEIPVP 1000
            NMDEKYTGLKKQL DLCGLNSEQILLAEVH SNIKNFPQDNQKV+LSVSGFLCAFEIPVP
Sbjct: 739  NMDEKYTGLKKQLRDLCGLNSEQILLAEVHDSNIKNFPQDNQKVQLSVSGFLCAFEIPVP 798

Query: 1001 VSPISASSPTQTDFSSSPSTNEMFTLTTNGDLPRPIFIPNGMPNTVVPCGTEKNFTNGMV 1060
             SPISASSPTQ DFSSSPSTN MFTLTTNGDLP+PIFIPNGMPNTVVPCGTEKNFTNGMV
Sbjct: 799  SSPISASSPTQIDFSSSPSTNGMFTLTTNGDLPKPIFIPNGMPNTVVPCGTEKNFTNGMV 858

Query: 1061 NGHMPSLPDSPFTGYIIAVHRKMMRTELYFLSSQKNRPSLFGMPLIVPCTVHTRKKDLYD 1120
            NGHMPSLPDSPFTGYIIAVHRKMMRTELYFLS Q+NRPSLFGMPLIVPCTVHTRKKDLYD
Sbjct: 859  NGHMPSLPDSPFTGYIIAVHRKMMRTELYFLSPQENRPSLFGMPLIVPCTVHTRKKDLYD 918

Query: 1121 AVWIQVSRLASPLPPQEASNHAQDCDDSMGYQYPFTLRVVQKDGNSCAWCPWYRFCRGCK 1180
            AVWIQVS LA PLPPQEAS HAQD D+ MGYQYPFTLRVVQKDGNSCAWCP YRFCRGCK
Sbjct: 919  AVWIQVSWLARPLPPQEASIHAQDRDNCMGYQYPFTLRVVQKDGNSCAWCPQYRFCRGCK 978

Query: 1181 IDCGEDRAFIGNAYIAVDWDPTALHLRYQTSQERVVDEHESVEQSRRAQAEPINLDSCLR 1240
            IDCGEDRAFIGNAYIAVDW PTALHLRYQTSQERVVD+HESVEQSRRAQAEPINLDSCLR
Sbjct: 979  IDCGEDRAFIGNAYIAVDWHPTALHLRYQTSQERVVDKHESVEQSRRAQAEPINLDSCLR 1038

Query: 1241 AFTSEEELGENEMYYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQFVNGRWIKSQKIVK 1300
            AFTSEEELGE+EMYYCSKCKTHCLATKKLDLWRLPP LIIHLKRFQFVN +WIKSQKIV+
Sbjct: 1039 AFTSEEELGESEMYYCSKCKTHCLATKKLDLWRLPPFLIIHLKRFQFVNDQWIKSQKIVR 1098

Query: 1301 FPRESFDPSAFLVPRDPALCQHKPLTPQGDELSEPRILAREVKKVDAQSSAGEEDVLLSK 1360
            F RESFDPSAFLVPRDPALCQHKPLTPQGDELS+PRILAREVKKVDAQSSAG+ED+LLSK
Sbjct: 1099 FLRESFDPSAFLVPRDPALCQHKPLTPQGDELSKPRILAREVKKVDAQSSAGKEDMLLSK 1158

Query: 1361 SPSSLSANIISSPKGSPSSSRKSGTSCPSSKNSSPNSSPRTLGRSKGRLRLPQIGSKNKL 1420
            SPSSLSANI SSPKGSPSSSRKSGTSCPSSKNSSPNSSPRTLGRSKGRLRLPQIGSKNK 
Sbjct: 1159 SPSSLSANISSSPKGSPSSSRKSGTSCPSSKNSSPNSSPRTLGRSKGRLRLPQIGSKNKP 1218

Query: 1421 SSSKENLDASKENGAGQICELADALSRGHVLGGSQPELVTPQDHEVALANGFLYEHEACG 1480
            SSSK+NLDASKENGAGQICELADALSRGH+ GGSQPELVTPQDHEVALANGFLYEHEACG
Sbjct: 1219 SSSKKNLDASKENGAGQICELADALSRGHMRGGSQPELVTPQDHEVALANGFLYEHEACG 1278

Query: 1481 N----GYSNGQLGNHSEEDSTDDQREDTRIKPIYNLYAISCHSGILGGGHYVTYAKNPNC 1536
            N    GYSNGQLGNHSEEDSTDDQREDT IKPIYNLYAISCHSGIL GGHY+TYAKNPNC
Sbjct: 1279 NGCGDGYSNGQLGNHSEEDSTDDQREDTHIKPIYNLYAISCHSGILSGGHYITYAKNPNC 1338

Query: 1537 KWYCYNDSSCKELHPDEIDTDSAYILFYEQQGIDYAQFLPKTDGKKMADTSSMDEDFESD 1596
            KWYCYNDSSC+ELHPDEIDTDSAYILFYEQQGIDYAQFLPK DGKKMADTSS DED ESD
Sbjct: 1339 KWYCYNDSSCEELHPDEIDTDSAYILFYEQQGIDYAQFLPKIDGKKMADTSSTDEDSESD 1398

Query: 1597 YKKYCVLQ 1604
            Y+KY +LQ
Sbjct: 1399 YEKYSMLQ 1406


>gi|239751420 PREDICTED: similar to hCG2039376 [Homo sapiens]
          Length = 858

 Score = 1343 bits (3477), Expect = 0.0
 Identities = 677/793 (85%), Positives = 695/793 (87%), Gaps = 29/793 (3%)

Query: 19  RVTDVELKRLKDAFKRTCGLSYYMGQHCFIREVLGDGVPPKVAEVIYCSFGGTSKGLHFN 78
           RVTDVELKRLKDAFKRTCGLSYYMGQHCFIREVLGDGVPPKVAEVIYCSFGGTSKGLHFN
Sbjct: 87  RVTDVELKRLKDAFKRTCGLSYYMGQHCFIREVLGDGVPPKVAEVIYCSFGGTSKGLHFN 146

Query: 79  NLIVGLVLLTRGKDEEKAKYIFSLFSSESGNYVIREEMERMLHVVDGKVPDTLRKCFSEG 138
           NLIVGLVLLTRGKDEEKAKYIFSLFSSESGNYVIREEMERMLHVVDGKVPDTLRKCFSEG
Sbjct: 147 NLIVGLVLLTRGKDEEKAKYIFSLFSSESGNYVIREEMERMLHVVDGKVPDTLRKCFSEG 206

Query: 139 EKVNYEKFRNWLFLNKDAFTFSRWLLSGGVYVTLTDDSDTPTFYQTLAGVTHLEESDIID 198
           EKVNYEKFRNWLFLNKDAFTFSRWLLSGGVYVTLTDDSDTPTFYQTLAGVTHLEESDIID
Sbjct: 207 EKVNYEKFRNWLFLNKDAFTFSRWLLSGGVYVTLTDDSDTPTFYQTLAGVTHLEESDIID 266

Query: 199 LEKRYWLLKAQSRTGRFDLETFGPLVSPPIRPSLSEGLFNAFDENRDNHIDFKEISCGLS 258
           LEKRYWLLKAQSRTGRFDLETFGPLVSPPIRPSLSEGLFNAFDENRDNHIDFKEISCGLS
Sbjct: 267 LEKRYWLLKAQSRTGRFDLETFGPLVSPPIRPSLSEGLFNAFDENRDNHIDFKEISCGLS 326

Query: 259 ACCRGPLAERQKFCFKVFDVDRDGVLSRVELRDMVVALLEVWKDNRTDDIPELHMDLSDI 318
           ACCRGPLAERQKFCFKVFDVDRDGVLSRVELRDMVVALLEVWKDNRTDDIPELHMDLSDI
Sbjct: 327 ACCRGPLAERQKFCFKVFDVDRDGVLSRVELRDMVVALLEVWKDNRTDDIPELHMDLSDI 386

Query: 319 VEGILNAHDTTKMGHLTLEDYQIWSVKNVLANEFLNLLFQVCHIVLGLRPATPEEEGQII 378
           VEGILNAHDTTKMGHLTLEDYQIWSVKNVLANEFLNLLFQVCHIVLGLRPATPEEEGQII
Sbjct: 387 VEGILNAHDTTKMGHLTLEDYQIWSVKNVLANEFLNLLFQVCHIVLGLRPATPEEEGQII 446

Query: 379 RGWLERESRYGLQAGHNWFIISMQWWQQWKEYVKYDANPVVIEPSSVLNGGKYSFGTAAH 438
           RGWLERESRYGLQAGHNWFIISMQWWQQWKEYVKYDANPVVIEPSSVLNGGKYSFGTAAH
Sbjct: 447 RGWLERESRYGLQAGHNWFIISMQWWQQWKEYVKYDANPVVIEPSSVLNGGKYSFGTAAH 506

Query: 439 PMEQVEDRIGSSLSYVNTTEEKFSDNISTASEASETAGSGFLYSATPGADVCFARQHNTS 498
           PMEQVEDRIGSSLSYVNTTEEKFSDNISTASEASETAGSGFLYSATPGADVCFARQHNTS
Sbjct: 507 PMEQVEDRIGSSLSYVNTTEEKFSDNISTASEASETAGSGFLYSATPGADVCFARQHNTS 566

Query: 499 DNNNQCLLGANGNILLHLNPQKPGAIDNQPLVTQEPVKATSLTLEGGRLKRTPQLIHGRD 558
           DNNNQCLLGANGNILLHLNPQKPGAIDNQPLVTQEPVKATSLTLEGGRLKRTPQLIHGRD
Sbjct: 567 DNNNQCLLGANGNILLHLNPQKPGAIDNQPLVTQEPVKATSLTLEGGRLKRTPQLIHGRD 626

Query: 559 YEMVPEPVWRALYHWYGANLALPRPVIKNSKTDIPELELFPRYLLFLRQQPATRTQQSNI 618
           YEMVPEPVWRALYHWYGANLALPRPV   +     E    P  +  L +  A R++    
Sbjct: 627 YEMVPEPVWRALYHWYGANLALPRPVSIVNSALYKEQNTLPPVIPALWKAEAGRSRGQEF 686

Query: 619 WVNMGNVPSPNAPLKRVLAYTGCFSRMQTIKEIHEYLSQRLRIKEEDMRLW---LYNSEN 675
             ++ N+  P +     +A  G    +          SQ   I       W   L+  + 
Sbjct: 687 ETSLANIVKPQS---CCVAQAGL--ELLVSSSPSALASQSAGITGMSHCTWLVVLFLFDF 741

Query: 676 YLTLLDDEDHKLEYLKIQDEQHLVIEVRNKDMSWPEEMSFIANSSKIDRHKVPTEKGATG 735
           Y +LL                     +  K  S  E++ +  NSSKIDRHKVPTEKGATG
Sbjct: 742 YCSLL---------------------ILKKKSSVAEDIGYETNSSKIDRHKVPTEKGATG 780

Query: 736 LSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLVQELW 795
           LSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLVQELW
Sbjct: 781 LSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLVQELW 840

Query: 796 SGTQKNVAPLKLR 808
           SGTQKNVAPLKLR
Sbjct: 841 SGTQKNVAPLKLR 853


>gi|24234683 ubiquitin specific peptidase 11 [Homo sapiens]
          Length = 963

 Score =  292 bits (747), Expect = 2e-78
 Identities = 172/455 (37%), Positives = 252/455 (55%), Gaps = 43/455 (9%)

Query: 521 PGAIDNQPLVTQEPVKATSLTLEGGRLKRTPQLIHGRDYEMVPEPVWRALYHWYGANLAL 580
           PG I+N  L   E            RLK    L+ G DY ++P   W  L  WYG  L  
Sbjct: 128 PGCINNATLFQDEI---------NWRLKEG--LVEGEDYVLLPAAAWHYLVSWYG--LEH 174

Query: 581 PRPVIKNSKTDIPEL---ELFPRYLLFLRQQPATRTQQSNIWVNMGNVPSPNAPLKRVLA 637
            +P I+    ++P +   E++P  LL +R     ++                        
Sbjct: 175 GQPPIERKVIELPNIQKVEVYPVELLLVRHNDLGKS------------------------ 210

Query: 638 YTGCFSRMQTIKEIHEYLSQRLRIK-EEDMRLWLYNSENYLTLLDDEDHKLEYLKIQDEQ 696
           +T  FS   +I  +     +R  ++ +ED RLW  NSE  L  L D    +    ++  Q
Sbjct: 211 HTVQFSHTDSIGLVLRTARERFLVEPQEDTRLWAKNSEGSLDRLYDTHITVLDAALETGQ 270

Query: 697 HLVIEVRNKDMSWPEEMSFIANSSKIDRHK-VPTEKGATGLSNLGNTCFMNSSIQCVSNT 755
            +++E R KD +WP     + N++  +  +    + G  GL+NLGNTCFMNS++QC+SN 
Sbjct: 271 LIIMETRKKDGTWPSAQLHVMNNNMSEEDEDFKGQPGICGLTNLGNTCFMNSALQCLSNV 330

Query: 756 QPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGTQKNVAPLKLRWTIAKYA 815
             LT+YF++  +L ELN  NP+GMKG +A+ Y DLV++ WSG  +++ P   +  +  +A
Sbjct: 331 PQLTEYFLNNCYLEELNFRNPLGMKGEIAEAYADLVKQAWSGHHRSIVPHVFKNKVGHFA 390

Query: 816 PRFNGFQQQDSQELLAFLLDGLHEDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRN 875
            +F G+QQ DSQELL+FLLDGLHEDLNRV +K YVEL D+ GRPD EVA EAW NH RRN
Sbjct: 391 SQFLGYQQHDSQELLSFLLDGLHEDLNRVKKKEYVELCDAAGRPDQEVAQEAWQNHKRRN 450

Query: 876 RSIVVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSYMHLEITVIKLD-GTTPV 934
            S++VD FHG  +S + C  CG++SV FDPF +LS+PLP+     LE+  I +D    P 
Sbjct: 451 DSVIVDTFHGLFKSTLVCPDCGNVSVTFDPFCYLSVPLPISHKRVLEVFFIPMDPRRKPE 510

Query: 935 RYGLRLNMDEKYTGLKKQLSDLCGLNSEQILLAEV 969
           ++ L +    K + L   LS   G++ E++++A+V
Sbjct: 511 QHRLVVPKKGKISDLCVALSKHTGISPERMMVADV 545



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 48/120 (40%), Positives = 64/120 (53%), Gaps = 2/120 (1%)

Query: 1194 YIAVDWDPTALHLRYQTSQERVVDEHESVEQSRRAQAEPINLDSCLRAFTSEEELGENEM 1253
            YIA+DW+P      Y   +     +H+ V    +    P+ L  C+  FT+ E L +   
Sbjct: 742  YIAIDWEPEMKKRYYDEVEAEGYVKHDCVGYVMKKA--PVRLQECIELFTTVETLEKENP 799

Query: 1254 YYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQFVNGRWIKSQKIVKFPRESFDPSAFLV 1313
            +YC  CK H LATKKLDLW LP ILIIHLKRF +      K   +V+FP    D S F++
Sbjct: 800  WYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSREKLDTLVEFPIRDLDFSEFVI 859



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 22/61 (36%), Positives = 43/61 (70%), Gaps = 1/61 (1%)

Query: 1510 YNLYAISCHSGILGGGHYVTYAKNPNC-KWYCYNDSSCKELHPDEIDTDSAYILFYEQQG 1568
            Y+L A+S H G +  GHY T+A N +  +W+ ++D+S   ++ ++I++ +AY+LFY++Q 
Sbjct: 872  YDLIAVSNHYGGMRDGHYTTFACNKDSGQWHYFDDNSVSPVNENQIESKAAYVLFYQRQD 931

Query: 1569 I 1569
            +
Sbjct: 932  V 932



 Score = 35.4 bits (80), Expect = 0.45
 Identities = 16/45 (35%), Positives = 25/45 (55%), Gaps = 2/45 (4%)

Query: 368 PATPEEEGQIIRGWLERESRYGLQAGHNWFIISMQWWQQWKEYVK 412
           P    +  QI  G   RE    L+AG +WF++   W++QW+ YV+
Sbjct: 76  PGLDSQWRQIENGESGRERP--LRAGESWFLVEKHWYKQWEAYVQ 118


>gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens]
          Length = 916

 Score =  290 bits (743), Expect = 6e-78
 Identities = 171/463 (36%), Positives = 256/463 (55%), Gaps = 49/463 (10%)

Query: 521 PGAIDNQPLVTQEPVKATSLTLEGGRLKRTPQLIHGRDYEMVPEPVWRALYHWYGANLAL 580
           PG IDN  L +           E   LK    LI   DY +VP   W  L +WYG  +  
Sbjct: 66  PGPIDNSGLFSDP---------ESQTLKE--HLIDELDYVLVPTEAWNKLLNWYGC-VEG 113

Query: 581 PRPVIKNSKTDIPELELFPRY----LLFLRQQPATRTQQSNIWVNMGNVPSPNAPLKRVL 636
            +P+++     + E  LF ++    +  L  +    +  +N+                  
Sbjct: 114 QQPIVRK----VVEHGLFVKHCKVEVYLLELKLCENSDPTNV------------------ 151

Query: 637 AYTGC-FSRMQTIKEIHEYLSQRLRIK-EEDMRLWLYNSENYLTLLDDEDHKLEYLKIQD 694
               C FS+  TI  I + + +   I  E + RLW     N    L   D+ ++   +  
Sbjct: 152 --LSCHFSKADTIATIEKEMRKLFNIPAERETRLWNKYMSNTYEQLSKLDNTVQDAGLYQ 209

Query: 695 EQHLVIEVRNKDMSWPEEM------SFIANSSKIDRHKVPTEKGATGLSNLGNTCFMNSS 748
            Q LVIE +N+D +WP +        F A+ +  +      + G  GL NLGNTCFMNS+
Sbjct: 210 GQVLVIEPQNEDGTWPRQTLQSNGSGFSASYNCQEPPSSHIQPGLCGLGNLGNTCFMNSA 269

Query: 749 IQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGTQKNVAPLKLR 808
           +QC+SNT PLT YF+   +  E+NR NP+GMKG +A+ Y +L++++WSG   +VAP   +
Sbjct: 270 LQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELIKQMWSGRDAHVAPRMFK 329

Query: 809 WTIAKYAPRFNGFQQQDSQELLAFLLDGLHEDLNRVHEKPYVELKDSDGRPDWEVAAEAW 868
             + ++AP+F+G+QQQDSQELLAFLLDGLHEDLNRV +KPY+ELKD++GRPD  VA EAW
Sbjct: 330 TQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYLELKDANGRPDAVVAKEAW 389

Query: 869 DNHLRRNRSIVVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSYMHLEITVIKL 928
           +NH  RN S++VD FHG  +S + C  C  +SV FDPF +L+LPLP+     +E+ ++  
Sbjct: 390 ENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKDRVMEVFLVPA 449

Query: 929 D-GTTPVRYGLRLNMDEKYTGLKKQLSDLCGLNSEQILLAEVH 970
           D    P +Y + + +    + L + LS L G+ +E +++A+V+
Sbjct: 450 DPHCRPTQYRVTVPLMGAVSDLCEALSRLSGIAAENMVVADVY 492



 Score = 95.1 bits (235), Expect = 5e-19
 Identities = 46/119 (38%), Positives = 68/119 (57%), Gaps = 2/119 (1%)

Query: 1195 IAVDWDPTALHLRYQTSQERVVDEHESVEQSRRAQAEPINLDSCLRAFTSEEELGENEMY 1254
            +A+DWD     L Y   +    ++H S+ Q ++ +   + L  C+  FT+ E LGE++ +
Sbjct: 691  LAMDWDSETRRLYYDEQESEAYEKHVSMLQPQKKKKTTVALRDCIELFTTMETLGEHDPW 750

Query: 1255 YCSKCKTHCLATKKLDLWRLPPILIIHLKRFQFVNGRW-IKSQKIVKFPRESFDPSAFL 1312
            YC  CK H  ATKK DLW LP IL++HLKRF + N  W  K   +V+FP    + S F+
Sbjct: 751  YCPNCKKHQQATKKFDLWSLPKILVVHLKRFSY-NRYWRDKLDTVVEFPIRGLNMSEFV 808



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 28/64 (43%), Positives = 43/64 (67%), Gaps = 1/64 (1%)

Query: 1509 IYNLYAISCHSGILGGGHYVTYAKNP-NCKWYCYNDSSCKELHPDEIDTDSAYILFYEQQ 1567
            +Y+L A+S H G +G GHY  YAKN  N KWY ++DS+      D+I T +AY+LFY+++
Sbjct: 817  VYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYFDDSNVSLASEDQIVTKAAYVLFYQRR 876

Query: 1568 GIDY 1571
              ++
Sbjct: 877  DDEF 880



 Score = 38.1 bits (87), Expect = 0.069
 Identities = 13/29 (44%), Positives = 21/29 (72%)

Query: 387 RYGLQAGHNWFIISMQWWQQWKEYVKYDA 415
           R  LQ G  W++I  +W++QWK+YV +D+
Sbjct: 25  RTTLQRGAQWYLIDSRWFKQWKKYVGFDS 53


>gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens]
          Length = 952

 Score =  289 bits (740), Expect = 1e-77
 Identities = 174/484 (35%), Positives = 264/484 (54%), Gaps = 38/484 (7%)

Query: 534 PVKATSLTLEGGRLKRTPQLIHGRDYEMVPEPVWRALYHWYGANLALPRPVIKNSKTDIP 593
           P+  + L  +G        LI   DY ++P   W  L  WY   +    P+ +     + 
Sbjct: 64  PIDNSGLLKDGDAQSLKEHLIDELDYILLPTEGWNKLVSWYTL-MEGQEPIARK----VV 118

Query: 594 ELELFPRYLLFLRQQPATRTQQSNIWVNMGNVPSPNAPLKRVLAYTGCFSRMQTIKEIHE 653
           E  +F ++          +  ++    NM NV             T  FS+  TI  I +
Sbjct: 119 EQGMFVKHCKVEVYLTELKLCENG---NMNNV------------VTRRFSKADTIDTIEK 163

Query: 654 YLSQRLRIKEE-DMRLWLYNSENYLTLLDDEDHKLEYLKIQDEQHLVIEVRNKDMSWPEE 712
            + +   I +E + RLW     N    L+  D  ++   +   Q LVIE +N+D +WP  
Sbjct: 164 EIRKIFSIPDEKETRLWNKYMSNTFEPLNKPDSTIQDAGLYQGQVLVIEQKNEDGTWPRG 223

Query: 713 MSF--IANSS---------KIDRHKVP----TEKGATGLSNLGNTCFMNSSIQCVSNTQP 757
            S   + NS+         K   +  P     + G  GLSNLGNTCFMNS+IQC+SNT P
Sbjct: 224 PSTPNVKNSNYCLPSYTAYKNYDYSEPGRNNEQPGLCGLSNLGNTCFMNSAIQCLSNTPP 283

Query: 758 LTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGTQKNVAPLKLRWTIAKYAPR 817
           LT+YF++ ++  ELN  NP+GM+G +AK Y +L++++WSG    V P   +  + ++AP+
Sbjct: 284 LTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQ 343

Query: 818 FNGFQQQDSQELLAFLLDGLHEDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRS 877
           F+G+QQQD QELLAFLLDGLHEDLNR+ +KPY++LKD+DGRPD  VA EAW+NHL+RN S
Sbjct: 344 FSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYIQLKDADGRPDKVVAEEAWENHLKRNDS 403

Query: 878 IVVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSYMHLEITVIKLDG-TTPVRY 936
           I+VD+FHG  +S + C  C  ISV FDPF +L+LPLPM     LE+ ++++D  T P++Y
Sbjct: 404 IIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMKKERTLEVYLVRMDPLTKPMQY 463

Query: 937 GLRLNMDEKYTGLKKQLSDLCGLNSEQILLAEVHGSNI-KNFPQDNQKVRLSVSGFLCAF 995
            + +        L   LS L G+ ++++++ +++     + F  D     +     +  F
Sbjct: 464 KVVVPKIGNILDLCTALSALSGIPADKMIVTDIYNHRFHRIFAMDENLSSIMERDDIYVF 523

Query: 996 EIPV 999
           EI +
Sbjct: 524 EINI 527



 Score =  101 bits (251), Expect = 7e-21
 Identities = 49/131 (37%), Positives = 75/131 (57%), Gaps = 3/131 (2%)

Query: 1193 AYIAVDWDPTALHLRYQTSQERVVDEHESVEQSRRAQAEP-INLDSCLRAFTSEEELGEN 1251
            +++A+DWDP      +  +     ++HESVE   +   +P + L  C+  FT++E+LG  
Sbjct: 718  SFLALDWDPDLKKRYFDENAAEDFEKHESVEY--KPPKKPFVKLKDCIELFTTKEKLGAE 775

Query: 1252 EMYYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQFVNGRWIKSQKIVKFPRESFDPSAF 1311
            + +YC  CK H  ATKKLDLW LPP+L++HLKRF +      K   +V FP    D S F
Sbjct: 776  DPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRDKLDTLVDFPINDLDMSEF 835

Query: 1312 LVPRDPALCQH 1322
            L+  +   C++
Sbjct: 836  LINPNAGPCRY 846



 Score = 65.1 bits (157), Expect = 5e-10
 Identities = 35/92 (38%), Positives = 53/92 (57%), Gaps = 5/92 (5%)

Query: 1510 YNLYAISCHSGILGGGHYVTYAKN-PNCKWYCYNDSSCKELHPDEIDTDSAYILFYEQQ- 1567
            YNL A+S H G +GGGHY  +AKN  + KWY ++DSS      D+I + +AY+LFY++Q 
Sbjct: 846  YNLIAVSNHYGGMGGGHYTAFAKNKDDGKWYYFDDSSVSTASEDQIVSKAAYVLFYQRQD 905

Query: 1568 ---GIDYAQFLPKTDGKKMADTSSMDEDFESD 1596
               G  +     +T G   A    ++ D +S+
Sbjct: 906  TFSGTGFFPLDRETKGASAATGIPLESDEDSN 937



 Score = 38.5 bits (88), Expect = 0.053
 Identities = 18/64 (28%), Positives = 30/64 (46%), Gaps = 6/64 (9%)

Query: 390 LQAGHNWFIISMQWWQQWKEYV------KYDANPVVIEPSSVLNGGKYSFGTAAHPMEQV 443
           L+ G  W+++  +W++QWK+YV      KY      + P  + N G    G A    E +
Sbjct: 24  LRKGDTWYLVDSRWFKQWKKYVGFDSWDKYQMGDQNVYPGPIDNSGLLKDGDAQSLKEHL 83

Query: 444 EDRI 447
            D +
Sbjct: 84  IDEL 87


>gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens]
          Length = 963

 Score =  276 bits (707), Expect = 9e-74
 Identities = 177/510 (34%), Positives = 262/510 (51%), Gaps = 96/510 (18%)

Query: 521 PGAIDNQPLVTQEPVKATSLTLEGGRLKRTPQLIHGRDYEMVPEPVWRALYHWYGANLAL 580
           PG IDN  L +           E   LK    LI   DY +VP   W  L +WYG  +  
Sbjct: 66  PGPIDNSGLFSDP---------ESQTLKE--HLIDELDYVLVPTEAWNKLLNWYGC-VEG 113

Query: 581 PRPVIKNSKTDIPELELFPRY----LLFLRQQPATRTQQSNIWVNMGNVPSPNAPLKRVL 636
            +P+++     + E  LF ++    +  L  +    +  +N+                  
Sbjct: 114 QQPIVRK----VVEHGLFVKHCKVEVYLLELKLCENSDPTNV------------------ 151

Query: 637 AYTGC-FSRMQTIKEIHEYLSQRLRIK-EEDMRLWLYNSENYLTLLDDEDHKLEYLKIQD 694
               C FS+  TI  I + + +   I  E + RLW     N    L   D+ ++   +  
Sbjct: 152 --LSCHFSKADTIATIEKEMRKLFNIPAERETRLWNKYMSNTYEQLSKLDNTVQDAGLYQ 209

Query: 695 EQHLVIEVRNKDMSWPEEM-----------------------------SFIAN------- 718
            Q LVIE +N+D +WP +                              S IAN       
Sbjct: 210 GQVLVIEPQNEDGTWPRQTLQSKSSTAPSRNFTTSPKSSASPYSSVSASLIANGDSTSTC 269

Query: 719 ---SSKIDR-----------HKVPT---EKGATGLSNLGNTCFMNSSIQCVSNTQPLTQY 761
              SS + R            + P+   + G  GL NLGNTCFMNS++QC+SNT PLT Y
Sbjct: 270 GMHSSGVSRGGSGFSASYNCQEPPSSHIQPGLCGLGNLGNTCFMNSALQCLSNTAPLTDY 329

Query: 762 FISGRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGTQKNVAPLKLRWTIAKYAPRFNGF 821
           F+   +  E+NR NP+GMKG +A+ Y +L++++WSG   +VAP   +  + ++AP+F+G+
Sbjct: 330 FLKDEYEAEINRDNPLGMKGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGY 389

Query: 822 QQQDSQELLAFLLDGLHEDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIVVD 881
           QQQDSQELLAFLLDGLHEDLNRV +KPY+ELKD++GRPD  VA EAW+NH  RN S++VD
Sbjct: 390 QQQDSQELLAFLLDGLHEDLNRVKKKPYLELKDANGRPDAVVAKEAWENHRLRNDSVIVD 449

Query: 882 LFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSYMHLEITVIKLD-GTTPVRYGLRL 940
            FHG  +S + C  C  +SV FDPF +L+LPLP+     +E+ ++  D    P +Y + +
Sbjct: 450 TFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKDRVMEVFLVPADPHCRPTQYRVTV 509

Query: 941 NMDEKYTGLKKQLSDLCGLNSEQILLAEVH 970
            +    + L + LS L G+ +E +++A+V+
Sbjct: 510 PLMGAVSDLCEALSRLSGIAAENMVVADVY 539



 Score = 95.1 bits (235), Expect = 5e-19
 Identities = 46/119 (38%), Positives = 68/119 (57%), Gaps = 2/119 (1%)

Query: 1195 IAVDWDPTALHLRYQTSQERVVDEHESVEQSRRAQAEPINLDSCLRAFTSEEELGENEMY 1254
            +A+DWD     L Y   +    ++H S+ Q ++ +   + L  C+  FT+ E LGE++ +
Sbjct: 738  LAMDWDSETRRLYYDEQESEAYEKHVSMLQPQKKKKTTVALRDCIELFTTMETLGEHDPW 797

Query: 1255 YCSKCKTHCLATKKLDLWRLPPILIIHLKRFQFVNGRW-IKSQKIVKFPRESFDPSAFL 1312
            YC  CK H  ATKK DLW LP IL++HLKRF + N  W  K   +V+FP    + S F+
Sbjct: 798  YCPNCKKHQQATKKFDLWSLPKILVVHLKRFSY-NRYWRDKLDTVVEFPIRGLNMSEFV 855



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 28/64 (43%), Positives = 43/64 (67%), Gaps = 1/64 (1%)

Query: 1509 IYNLYAISCHSGILGGGHYVTYAKNP-NCKWYCYNDSSCKELHPDEIDTDSAYILFYEQQ 1567
            +Y+L A+S H G +G GHY  YAKN  N KWY ++DS+      D+I T +AY+LFY+++
Sbjct: 864  VYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYFDDSNVSLASEDQIVTKAAYVLFYQRR 923

Query: 1568 GIDY 1571
              ++
Sbjct: 924  DDEF 927



 Score = 38.1 bits (87), Expect = 0.069
 Identities = 13/29 (44%), Positives = 21/29 (72%)

Query: 387 RYGLQAGHNWFIISMQWWQQWKEYVKYDA 415
           R  LQ G  W++I  +W++QWK+YV +D+
Sbjct: 25  RTTLQRGAQWYLIDSRWFKQWKKYVGFDS 53


>gi|57529246 ubiquitin thioesterase 19 [Homo sapiens]
          Length = 1318

 Score =  199 bits (505), Expect = 2e-50
 Identities = 112/272 (41%), Positives = 152/272 (55%), Gaps = 10/272 (3%)

Query: 732 GATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLV 791
           G TGL NLGNTCFMNS IQ +SNT+ L  +F       E+N  NP+G  G +A  +  L+
Sbjct: 495 GFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGTGGRLAIGFAVLL 554

Query: 792 QELWSGTQKNVAPLKLRWTIAKYAPRFNGFQQQDSQELLAFLLDGLHEDLNRVHEKPYVE 851
           + LW GT     P KL+  +A  A +F G+ Q D+QE +AFLLDGLHEDLNR+  KPY E
Sbjct: 555 RALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNRIQNKPYTE 614

Query: 852 LKDSDGRPDWEVAAEAWDNHLRRNRSIVVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSL 911
             DSDGRPD  VA EAW  H  RN S +VDLF GQ +S++ C  C  +S+ FDPF +L +
Sbjct: 615 TVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLPV 674

Query: 912 PLPMDSYMHLEITVIKLDGTTPVRYGLRLNMDEKYTG-LKKQLSDLCGLNSEQILLAEVH 970
           PLP    +       +   + P+++ + ++ +      +   LS    +  E + LAEV 
Sbjct: 675 PLPQKQKVLPVFYFAREPHSKPIKFLVSVSKENSTASEVLDSLSQSVHVKPENLRLAEV- 733

Query: 971 GSNIKN-----FPQDNQKVRLSVSGFLCAFEI 997
              IKN     F   +    +S S  L  FE+
Sbjct: 734 ---IKNRFHRVFLPSHSLDTVSPSDTLLCFEL 762



 Score = 74.3 bits (181), Expect = 9e-13
 Identities = 39/87 (44%), Positives = 51/87 (58%), Gaps = 1/87 (1%)

Query: 1228 AQAEPINLDSCLRAFTSEEELGENEMYYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQF 1287
            A+A    LD CL  FT  E L   E +YC +CK H  A+K+L LWRLP +LI+ LKRF F
Sbjct: 1053 ARAGHFTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSF 1112

Query: 1288 VNGRW-IKSQKIVKFPRESFDPSAFLV 1313
             +  W  K   +V+FP  + D S F +
Sbjct: 1113 RSFIWRDKINDLVEFPVRNLDLSKFCI 1139



 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 23/68 (33%), Positives = 37/68 (54%), Gaps = 8/68 (11%)

Query: 1508 PIYNLYAISCHSGILGGGHYVTYAKNPNCK--------WYCYNDSSCKELHPDEIDTDSA 1559
            P Y+LYA+  H G + GGHY   A+ PN +        W  ++DS+   +   ++ T  A
Sbjct: 1147 PSYDLYAVINHYGGMIGGHYTACARLPNDRSSQRSDVGWRLFDDSTVTTVDESQVVTRYA 1206

Query: 1560 YILFYEQQ 1567
            Y+LFY ++
Sbjct: 1207 YVLFYRRR 1214


>gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens]
          Length = 1118

 Score =  166 bits (421), Expect = 1e-40
 Identities = 90/223 (40%), Positives = 134/223 (60%), Gaps = 5/223 (2%)

Query: 704 NKDMSWPEEMSFIANSSKIDRHKVPTEKGA----TGLSNLGNTCFMNSSIQCVSNTQPLT 759
           NK   +P+      ++S+I R+  P   G+    TGL NLGNTC+MNS +QC+ N   L 
Sbjct: 744 NKPTCYPKAEISRLSASQI-RNLNPVFGGSGPALTGLRNLGNTCYMNSILQCLCNAPHLA 802

Query: 760 QYFISGRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGTQKNVAPLKLRWTIAKYAPRFN 819
            YF    +  ++NR+N +G KG +A+ +G +++ LW+G  + ++P   + TI K   +F 
Sbjct: 803 DYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFA 862

Query: 820 GFQQQDSQELLAFLLDGLHEDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIV 879
           G+ QQDSQELL FL+DGLHEDLN+   +   + +++D   D++ A  AW  H + N SI+
Sbjct: 863 GYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDHLDDFKAAEHAWQKHKQLNESII 922

Query: 880 VDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSYMHLE 922
           V LF GQ +S V+C TC   S  F+ F +LSLPL   S   L+
Sbjct: 923 VALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTSKCTLQ 965



 Score = 81.6 bits (200), Expect = 5e-15
 Identities = 37/87 (42%), Positives = 56/87 (64%), Gaps = 2/87 (2%)

Query: 1228 AQAEPINLDSCLRAFTSEEELGENEMYYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQF 1287
            A      L  CLR F+ EE+L +N  +YCS C+    + KK+++W+LPP+L++HLKRF +
Sbjct: 957  ASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSY 1016

Query: 1288 VNGRW-IKSQKIVKFPRESFDPSAFLV 1313
             +GRW  K Q  V FP E+ D S +++
Sbjct: 1017 -DGRWKQKLQTSVDFPLENLDLSQYVI 1042



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 23/60 (38%), Positives = 35/60 (58%), Gaps = 1/60 (1%)

Query: 1510 YNLYAISCHSGILGGGHYVTYAKN-PNCKWYCYNDSSCKELHPDEIDTDSAYILFYEQQG 1568
            YNL+++S H G L GGHY  Y KN    +W+ ++D    ++    + + +AYILFY   G
Sbjct: 1051 YNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYILFYTSLG 1110


>gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens]
          Length = 1118

 Score =  166 bits (421), Expect = 1e-40
 Identities = 90/223 (40%), Positives = 134/223 (60%), Gaps = 5/223 (2%)

Query: 704 NKDMSWPEEMSFIANSSKIDRHKVPTEKGA----TGLSNLGNTCFMNSSIQCVSNTQPLT 759
           NK   +P+      ++S+I R+  P   G+    TGL NLGNTC+MNS +QC+ N   L 
Sbjct: 744 NKPTCYPKAEISRLSASQI-RNLNPVFGGSGPALTGLRNLGNTCYMNSILQCLCNAPHLA 802

Query: 760 QYFISGRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGTQKNVAPLKLRWTIAKYAPRFN 819
            YF    +  ++NR+N +G KG +A+ +G +++ LW+G  + ++P   + TI K   +F 
Sbjct: 803 DYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFA 862

Query: 820 GFQQQDSQELLAFLLDGLHEDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIV 879
           G+ QQDSQELL FL+DGLHEDLN+   +   + +++D   D++ A  AW  H + N SI+
Sbjct: 863 GYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDHLDDFKAAEHAWQKHKQLNESII 922

Query: 880 VDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSYMHLE 922
           V LF GQ +S V+C TC   S  F+ F +LSLPL   S   L+
Sbjct: 923 VALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTSKCTLQ 965



 Score = 81.6 bits (200), Expect = 5e-15
 Identities = 37/87 (42%), Positives = 56/87 (64%), Gaps = 2/87 (2%)

Query: 1228 AQAEPINLDSCLRAFTSEEELGENEMYYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQF 1287
            A      L  CLR F+ EE+L +N  +YCS C+    + KK+++W+LPP+L++HLKRF +
Sbjct: 957  ASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSY 1016

Query: 1288 VNGRW-IKSQKIVKFPRESFDPSAFLV 1313
             +GRW  K Q  V FP E+ D S +++
Sbjct: 1017 -DGRWKQKLQTSVDFPLENLDLSQYVI 1042



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 23/60 (38%), Positives = 35/60 (58%), Gaps = 1/60 (1%)

Query: 1510 YNLYAISCHSGILGGGHYVTYAKN-PNCKWYCYNDSSCKELHPDEIDTDSAYILFYEQQG 1568
            YNL+++S H G L GGHY  Y KN    +W+ ++D    ++    + + +AYILFY   G
Sbjct: 1051 YNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYILFYTSLG 1110


>gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens]
          Length = 1118

 Score =  166 bits (421), Expect = 1e-40
 Identities = 90/223 (40%), Positives = 134/223 (60%), Gaps = 5/223 (2%)

Query: 704 NKDMSWPEEMSFIANSSKIDRHKVPTEKGA----TGLSNLGNTCFMNSSIQCVSNTQPLT 759
           NK   +P+      ++S+I R+  P   G+    TGL NLGNTC+MNS +QC+ N   L 
Sbjct: 744 NKPTCYPKAEISRLSASQI-RNLNPVFGGSGPALTGLRNLGNTCYMNSILQCLCNAPHLA 802

Query: 760 QYFISGRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGTQKNVAPLKLRWTIAKYAPRFN 819
            YF    +  ++NR+N +G KG +A+ +G +++ LW+G  + ++P   + TI K   +F 
Sbjct: 803 DYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFA 862

Query: 820 GFQQQDSQELLAFLLDGLHEDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIV 879
           G+ QQDSQELL FL+DGLHEDLN+   +   + +++D   D++ A  AW  H + N SI+
Sbjct: 863 GYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDHLDDFKAAEHAWQKHKQLNESII 922

Query: 880 VDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSYMHLE 922
           V LF GQ +S V+C TC   S  F+ F +LSLPL   S   L+
Sbjct: 923 VALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTSKCTLQ 965



 Score = 81.6 bits (200), Expect = 5e-15
 Identities = 37/87 (42%), Positives = 56/87 (64%), Gaps = 2/87 (2%)

Query: 1228 AQAEPINLDSCLRAFTSEEELGENEMYYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQF 1287
            A      L  CLR F+ EE+L +N  +YCS C+    + KK+++W+LPP+L++HLKRF +
Sbjct: 957  ASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSY 1016

Query: 1288 VNGRW-IKSQKIVKFPRESFDPSAFLV 1313
             +GRW  K Q  V FP E+ D S +++
Sbjct: 1017 -DGRWKQKLQTSVDFPLENLDLSQYVI 1042



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 23/60 (38%), Positives = 35/60 (58%), Gaps = 1/60 (1%)

Query: 1510 YNLYAISCHSGILGGGHYVTYAKN-PNCKWYCYNDSSCKELHPDEIDTDSAYILFYEQQG 1568
            YNL+++S H G L GGHY  Y KN    +W+ ++D    ++    + + +AYILFY   G
Sbjct: 1051 YNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYILFYTSLG 1110


>gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens]
          Length = 396

 Score =  152 bits (384), Expect = 3e-36
 Identities = 81/191 (42%), Positives = 114/191 (59%), Gaps = 7/191 (3%)

Query: 731 KGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKC--YG 788
           +G  GL NLGNTCFMNS +QC+SNT+ L  Y +   ++ +L+     G   H A    + 
Sbjct: 55  QGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHH----GSNAHTALVEEFA 110

Query: 789 DLVQELWSGTQKNV-APLKLRWTIAKYAPRFNGFQQQDSQELLAFLLDGLHEDLNRVHEK 847
            L+Q +W+ +  +V +P + +  I +YAPRF G+ QQD+QE L FLLDGLH ++NRV  +
Sbjct: 111 KLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLR 170

Query: 848 PYVELKDSDGRPDWEVAAEAWDNHLRRNRSIVVDLFHGQLRSQVKCKTCGHISVRFDPFN 907
           P    ++ D  PD E   + W  +L R  S + DLF GQL+S + C  CG+ S  FDPF 
Sbjct: 171 PKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFW 230

Query: 908 FLSLPLPMDSY 918
            LSLP+    Y
Sbjct: 231 DLSLPIAKRGY 241



 Score = 64.3 bits (155), Expect = 9e-10
 Identities = 27/58 (46%), Positives = 38/58 (65%), Gaps = 1/58 (1%)

Query: 1509 IYNLYAISCHSGILGGGHYVTYAKNPNC-KWYCYNDSSCKELHPDEIDTDSAYILFYE 1565
            +YNLYA+S HSG   GGHY  Y ++P   +W+ +NDSS   +   ++ T  AY+LFYE
Sbjct: 331  VYNLYAVSNHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYE 388



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 28/79 (35%), Positives = 37/79 (46%)

Query: 1233 INLDSCLRAFTSEEELGENEMYYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQFVNGRW 1292
            + L  C+R FT E+ L  +E   C +C+      KK  + R P IL++HLKRF     R 
Sbjct: 244  VTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRT 303

Query: 1293 IKSQKIVKFPRESFDPSAF 1311
             K    V FP    D   F
Sbjct: 304  SKLTTFVNFPLRDLDLREF 322


>gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo
           sapiens]
          Length = 605

 Score =  152 bits (384), Expect = 3e-36
 Identities = 81/191 (42%), Positives = 114/191 (59%), Gaps = 7/191 (3%)

Query: 731 KGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKC--YG 788
           +G  GL NLGNTCFMNS +QC+SNT+ L  Y +   ++ +L+     G   H A    + 
Sbjct: 264 QGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHH----GSNAHTALVEEFA 319

Query: 789 DLVQELWSGTQKNV-APLKLRWTIAKYAPRFNGFQQQDSQELLAFLLDGLHEDLNRVHEK 847
            L+Q +W+ +  +V +P + +  I +YAPRF G+ QQD+QE L FLLDGLH ++NRV  +
Sbjct: 320 KLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLR 379

Query: 848 PYVELKDSDGRPDWEVAAEAWDNHLRRNRSIVVDLFHGQLRSQVKCKTCGHISVRFDPFN 907
           P    ++ D  PD E   + W  +L R  S + DLF GQL+S + C  CG+ S  FDPF 
Sbjct: 380 PKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFW 439

Query: 908 FLSLPLPMDSY 918
            LSLP+    Y
Sbjct: 440 DLSLPIAKRGY 450



 Score = 64.3 bits (155), Expect = 9e-10
 Identities = 27/58 (46%), Positives = 38/58 (65%), Gaps = 1/58 (1%)

Query: 1509 IYNLYAISCHSGILGGGHYVTYAKNPNC-KWYCYNDSSCKELHPDEIDTDSAYILFYE 1565
            +YNLYA+S HSG   GGHY  Y ++P   +W+ +NDSS   +   ++ T  AY+LFYE
Sbjct: 540  VYNLYAVSNHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYE 597



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 28/79 (35%), Positives = 37/79 (46%)

Query: 1233 INLDSCLRAFTSEEELGENEMYYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQFVNGRW 1292
            + L  C+R FT E+ L  +E   C +C+      KK  + R P IL++HLKRF     R 
Sbjct: 453  VTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRT 512

Query: 1293 IKSQKIVKFPRESFDPSAF 1311
             K    V FP    D   F
Sbjct: 513  SKLTTFVNFPLRDLDLREF 531


>gi|62243586 ubiquitin-specific protease 21 [Homo sapiens]
          Length = 565

 Score =  118 bits (295), Expect = 5e-26
 Identities = 74/225 (32%), Positives = 111/225 (49%), Gaps = 35/225 (15%)

Query: 718 NSSKIDRHKVPTEKGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPI 777
           +  K+  H +    G  GL NLGNTCF+N+ +QC+S+T+PL  + +      E+      
Sbjct: 196 SDDKMAHHTLLLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGG--- 252

Query: 778 GMKGHMAKCYGDLVQELWSGTQ-KNVAPLKLRWTIAKYAPRFNGFQQQDSQELLAFLLDG 836
           G    + + + D++  LW     + V P + R    KY P F+G+ QQD+QE L  L++ 
Sbjct: 253 GRAQELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMER 312

Query: 837 LHEDLNR-----------------------VHEKPYVELKDSDGRPDWEVAAEAWDNHLR 873
           LH ++NR                       + E+P  EL D D       A   W  +L 
Sbjct: 313 LHLEINRRGRRAPPILANGPVPSPPRRGGALLEEP--ELSDDDR------ANLMWKRYLE 364

Query: 874 RNRSIVVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSY 918
           R  S +VDLF GQL+S +KC+ CG+ S  F+ F  LSLP+P   +
Sbjct: 365 REDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKGF 409



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 34/97 (35%), Positives = 46/97 (47%), Gaps = 7/97 (7%)

Query: 1233 INLDSCLRAFTSEEELGENEMYYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQFVNGRW 1292
            ++L  C   FT EEEL       C +C+    +TKKL + R P IL++HL RF    G  
Sbjct: 414  VSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSI 473

Query: 1293 IKSQKIVKFPRE-------SFDPSAFLVPRDPALCQH 1322
             KS   V FP +       + D +   V +  ALC H
Sbjct: 474  KKSSVGVDFPLQRLSLGDFASDKAGSPVYQLYALCNH 510



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 24/72 (33%), Positives = 37/72 (51%), Gaps = 5/72 (6%)

Query: 1496 STDDQREDTRIKPIYNLYAISCHSGILGGGHYVTYAKNPNCK--WYCYNDSSCKELHPDE 1553
            S  D   D    P+Y LYA+  HSG +  GHY    +   C+  W+ YNDS    +  ++
Sbjct: 488  SLGDFASDKAGSPVYQLYALCNHSGSVHYGHYTALCR---CQTGWHVYNDSRVSPVSENQ 544

Query: 1554 IDTDSAYILFYE 1565
            + +   Y+LFY+
Sbjct: 545  VASSEGYVLFYQ 556


>gi|74027267 ubiquitin-specific protease 21 [Homo sapiens]
          Length = 565

 Score =  118 bits (295), Expect = 5e-26
 Identities = 74/225 (32%), Positives = 111/225 (49%), Gaps = 35/225 (15%)

Query: 718 NSSKIDRHKVPTEKGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPI 777
           +  K+  H +    G  GL NLGNTCF+N+ +QC+S+T+PL  + +      E+      
Sbjct: 196 SDDKMAHHTLLLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGG--- 252

Query: 778 GMKGHMAKCYGDLVQELWSGTQ-KNVAPLKLRWTIAKYAPRFNGFQQQDSQELLAFLLDG 836
           G    + + + D++  LW     + V P + R    KY P F+G+ QQD+QE L  L++ 
Sbjct: 253 GRAQELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMER 312

Query: 837 LHEDLNR-----------------------VHEKPYVELKDSDGRPDWEVAAEAWDNHLR 873
           LH ++NR                       + E+P  EL D D       A   W  +L 
Sbjct: 313 LHLEINRRGRRAPPILANGPVPSPPRRGGALLEEP--ELSDDDR------ANLMWKRYLE 364

Query: 874 RNRSIVVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSY 918
           R  S +VDLF GQL+S +KC+ CG+ S  F+ F  LSLP+P   +
Sbjct: 365 REDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKGF 409



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 34/97 (35%), Positives = 46/97 (47%), Gaps = 7/97 (7%)

Query: 1233 INLDSCLRAFTSEEELGENEMYYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQFVNGRW 1292
            ++L  C   FT EEEL       C +C+    +TKKL + R P IL++HL RF    G  
Sbjct: 414  VSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSI 473

Query: 1293 IKSQKIVKFPRE-------SFDPSAFLVPRDPALCQH 1322
             KS   V FP +       + D +   V +  ALC H
Sbjct: 474  KKSSVGVDFPLQRLSLGDFASDKAGSPVYQLYALCNH 510



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 24/72 (33%), Positives = 37/72 (51%), Gaps = 5/72 (6%)

Query: 1496 STDDQREDTRIKPIYNLYAISCHSGILGGGHYVTYAKNPNCK--WYCYNDSSCKELHPDE 1553
            S  D   D    P+Y LYA+  HSG +  GHY    +   C+  W+ YNDS    +  ++
Sbjct: 488  SLGDFASDKAGSPVYQLYALCNHSGSVHYGHYTALCR---CQTGWHVYNDSRVSPVSENQ 544

Query: 1554 IDTDSAYILFYE 1565
            + +   Y+LFY+
Sbjct: 545  VASSEGYVLFYQ 556


>gi|148612811 ubiquitin specific protease 43 [Homo sapiens]
          Length = 1123

 Score =  113 bits (283), Expect = 1e-24
 Identities = 84/289 (29%), Positives = 133/289 (46%), Gaps = 18/289 (6%)

Query: 732  GATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLV 791
            GA GL N GNTCFMN+ +QC+SNT  L ++   GR+     R  P   +  + +    LV
Sbjct: 99   GAQGLKNHGNTCFMNAVVQCLSNTDLLAEFLALGRY-----RAAP--GRAEVTEQLAALV 151

Query: 792  QELWSGTQKNVAPLKLRWTIAKYAPRFNGFQQQDSQELLAFLLDGLHEDLNRVHEKPYVE 851
            + LW+         + +  ++KY  +F G  Q D+ E L +LLD +HEDL      P  E
Sbjct: 152  RALWTREYTPQLSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLEGSSRGPVSE 211

Query: 852  LKDSDGRPDWEVAAEAWDNHLRRNRSIVVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSL 911
                +     E         L   +S V   F  Q RS + C  C   S  FDPF  +SL
Sbjct: 212  KLPPEATKTSENCLSP-SAQLPLGQSFVQSHFQAQYRSSLTCPHCLKQSNTFDPFLCVSL 270

Query: 912  PLPMDSYMHLEIT-VIKLDGTTPVRYGLRLNMDEKYTGLKKQLSDLCGLNSEQILLAEVH 970
            P+P+     L +T V        +R GL + +      L+K +++  G+ +++++L E++
Sbjct: 271  PIPLRQTRFLSVTLVFPSKSQRFLRVGLAVPILSTVAALRKMVAEEGGVPADEVILVELY 330

Query: 971  GSNIKNFPQDNQKVRLSVSG-FLCAFEIPVPVSPISASSPTQTDFSSSP 1018
             S  +    D + +     G  + AF++P         SP+Q   S+ P
Sbjct: 331  PSGFQRSFFDEEDLNTIAEGDNVYAFQVP--------PSPSQGTLSAHP 371



 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 43/122 (35%), Positives = 64/122 (52%), Gaps = 1/122 (0%)

Query: 1195 IAVDWDPTALHLRYQTSQERVVDEHESVEQSRRA-QAEPINLDSCLRAFTSEEELGENEM 1253
            +AV+WD +     + + QE    + +SV Q ++A Q     LD C + +T EE+L +++ 
Sbjct: 501  LAVEWDSSVKERLFGSLQEERAQDADSVWQQQQAHQQHSCTLDECFQFYTKEEQLAQDDA 560

Query: 1254 YYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQFVNGRWIKSQKIVKFPRESFDPSAFLV 1313
            + C  C+       KL LW LP ILIIHLKRF  V  R  K   +VKFP    + +  + 
Sbjct: 561  WKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFCQVGERRNKLSTLVKFPLSGLNMAPHVA 620

Query: 1314 PR 1315
             R
Sbjct: 621  QR 622



 Score = 64.7 bits (156), Expect = 7e-10
 Identities = 28/60 (46%), Positives = 42/60 (70%), Gaps = 1/60 (1%)

Query: 1509 IYNLYAISCHSGILGGGHYVTYAKNP-NCKWYCYNDSSCKELHPDEIDTDSAYILFYEQQ 1567
            +Y+LYA+  H G L GGHY  Y +N  + +WY Y+DS+ + L  DE++T  AYILFY+++
Sbjct: 651  LYDLYAVCNHHGNLQGGHYTAYCRNSLDGQWYSYDDSTVEPLREDEVNTRGAYILFYQKR 710


>gi|120587027 ubiquitin specific peptidase 31 [Homo sapiens]
          Length = 1352

 Score =  103 bits (258), Expect = 1e-21
 Identities = 81/287 (28%), Positives = 131/287 (45%), Gaps = 33/287 (11%)

Query: 732 GATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNP-----------IGMK 780
           G  GL N GNTCFMN+++QC+SNT+   +Y   G+  Y   R  P              +
Sbjct: 126 GVAGLRNHGNTCFMNATLQCLSNTELFAEYLALGQ--YRAGRPEPSPDPEQPAGRGAQGQ 183

Query: 781 GHMAKCYGDLVQELWSGTQKNVAPLKLRWTIAKYAPRFNGFQQQDSQELLAFLLDGLHED 840
           G + +    LV+ LW+           +  ++K A ++ G  Q D+QE L +LLD +HED
Sbjct: 184 GEVTEQLAHLVRALWTLEYTPQHSRDFKTIVSKNALQYRGNSQHDAQEFLLWLLDRVHED 243

Query: 841 LNRVHE-------KPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIVVDLFHGQLRSQVKC 893
           LN   +       KP  E       P + V +           + V +LF  Q RS + C
Sbjct: 244 LNHSVKQSGQPPLKPPSETDMMPEGPSFPVCS-----------TFVQELFQAQYRSSLTC 292

Query: 894 KTCGHISVRFDPFNFLSLPLPMDSYMHLEITVIKLDGTTP-VRYGLRLNMDEKYTGLKKQ 952
             C   S  FDPF  +SLP+P+     L +TV+     +  +R G+ + +      L++ 
Sbjct: 293 PHCQKQSNTFDPFLCISLPIPLPHTRPLYVTVVYQGKCSHCMRIGVAVPLSGTVARLREA 352

Query: 953 LSDLCGLNSEQILLAEVHGSNI-KNFPQDNQKVRLSVSGFLCAFEIP 998
           +S    + ++QI+L E++     ++F   +    +  S  + AFE P
Sbjct: 353 VSMETKIPTDQIVLTEMYYDGFHRSFCDTDDLETVHESDCIFAFETP 399



 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 40/123 (32%), Positives = 63/123 (51%), Gaps = 2/123 (1%)

Query: 1195 IAVDWDPTALHLRYQTSQERVVDEHESV--EQSRRAQAEPINLDSCLRAFTSEEELGENE 1252
            + V+WD       +  +++  + + ESV  ++ R  Q +   L  C + +T EE L  ++
Sbjct: 556  LVVEWDKETRDFLFVNTEDEYIPDAESVRLQRERHHQPQTCTLSQCFQLYTKEERLAPDD 615

Query: 1253 MYYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQFVNGRWIKSQKIVKFPRESFDPSAFL 1312
             + C  CK     +  L LW LP +LIIHLKRF+    R +K Q +VKFP    D +  +
Sbjct: 616  AWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRFRQEGDRRMKLQNMVKFPLTGLDMTPHV 675

Query: 1313 VPR 1315
            V R
Sbjct: 676  VKR 678



 Score = 67.8 bits (164), Expect = 8e-11
 Identities = 29/60 (48%), Positives = 42/60 (70%), Gaps = 1/60 (1%)

Query: 1509 IYNLYAISCHSGILGGGHYVTYAKNP-NCKWYCYNDSSCKELHPDEIDTDSAYILFYEQQ 1567
            IY+LYA+  H G + GGHY  Y KN  +  WYC++DS  ++L  DE+ T +AYILFY+++
Sbjct: 706  IYDLYAVCNHHGTMQGGHYTAYCKNSVDGLWYCFDDSDVQQLSEDEVCTQTAYILFYQRR 765


>gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens]
          Length = 520

 Score = 96.7 bits (239), Expect = 2e-19
 Identities = 69/199 (34%), Positives = 98/199 (49%), Gaps = 28/199 (14%)

Query: 733 ATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGD--- 789
           ATGL NLGNTCFMN+ +Q +SN +    YF       EL      G + +  +  GD   
Sbjct: 158 ATGLRNLGNTCFMNAILQSLSNIEQFCCYF-KELPAVELRNGKTAGRRTYHTRSQGDNNV 216

Query: 790 -LVQE-------LWSGTQKNVAPLKLRWTIAKYAPRFNGFQQQDSQELLAFLLDGLHEDL 841
            LV+E       LW G+Q   +P  L + + K  P F G+QQQD+ E + +LLD LH +L
Sbjct: 217 SLVEEFRKTLCALWQGSQTAFSPESLFYVVWKIMPNFRGYQQQDAHEFMRYLLDHLHLEL 276

Query: 842 ----NRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRN--RSIVVDLFHGQLRSQVKCKT 895
               N V     ++          E +  +  N    N   ++V  +F G L+++V C  
Sbjct: 277 QGGFNGVSRSAILQ----------ENSTLSASNKCCINGASTVVTAIFGGILQNEVNCLI 326

Query: 896 CGHISVRFDPFNFLSLPLP 914
           CG  S +FDPF  LSL +P
Sbjct: 327 CGTESRKFDPFLDLSLDIP 345



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 35/92 (38%), Positives = 52/92 (56%), Gaps = 1/92 (1%)

Query: 1223 EQSRRAQAEPI-NLDSCLRAFTSEEELGENEMYYCSKCKTHCLATKKLDLWRLPPILIIH 1281
            ++S+  +  P+ +L  CLR+FT  EEL E E+Y C KCK    +TKK  + +LP +L +H
Sbjct: 351  KRSKNQENGPVCSLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKVLCLH 410

Query: 1282 LKRFQFVNGRWIKSQKIVKFPRESFDPSAFLV 1313
            LKRF +      K    V+FP    D   +L+
Sbjct: 411  LKRFHWTAYLRNKVDTYVEFPLRGLDMKCYLL 442



 Score = 41.6 bits (96), Expect = 0.006
 Identities = 21/57 (36%), Positives = 32/57 (56%), Gaps = 2/57 (3%)

Query: 1509 IYNLYAISCHSGI-LGGGHYVTYAKNPNCKWYCYNDSSCKELHPDEIDTDSAYILFY 1564
            +Y+L A+  H G  +G GHY  YA +   +W+ +NDS+      + +    AYILFY
Sbjct: 453  LYDLAAVVVHHGSGVGSGHYTAYATHEG-RWFHFNDSTVTLTDEETVVKAKAYILFY 508


>gi|45267835 ubiquitin specific protease 50 [Homo sapiens]
          Length = 339

 Score = 91.3 bits (225), Expect = 7e-18
 Identities = 55/187 (29%), Positives = 88/187 (47%), Gaps = 7/187 (3%)

Query: 728 PTEKGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCY 787
           P  +G TGL NLGNTC +N+  QC+ +  PL +YF++G+++  L +         +A  +
Sbjct: 38  PHFQGVTGLWNLGNTCCVNAISQCLCSILPLVEYFLTGKYITALQKFLLPSDCSEVATAF 97

Query: 788 GDLVQELWSGTQKNVAPLKLRWTIAKYAPRFNGFQQQDSQELLAFLLDGLHEDLNRVHEK 847
             L+ ++W G    V+P      +    P F    QQD+QE L  +L+ LHE L + H  
Sbjct: 98  AYLMTDMWLGDSDCVSPEIFWSALGNLYPAFTKKMQQDAQEFLICVLNELHEALKKYH-- 155

Query: 848 PYVELKDSDGRPDWEVAAEAWDNHLRRNRSIVVDLFHGQLRSQVKCKTCGHISVRFDPFN 907
                + S  +   +     W   +    SI+  LF  QL   + C  C   + + + F 
Sbjct: 156 --YSRRRSYEKGSTQRCCRKW---ITTETSIITQLFEEQLNYSIVCLKCEKCTYKNEVFT 210

Query: 908 FLSLPLP 914
             SLP+P
Sbjct: 211 VFSLPIP 217



 Score = 41.6 bits (96), Expect = 0.006
 Identities = 21/79 (26%), Positives = 38/79 (48%)

Query: 1234 NLDSCLRAFTSEEELGENEMYYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQFVNGRWI 1293
            +L  CL+ F  ++ L  N   +CS C+T      +  + + P I+I HLKRF        
Sbjct: 223  SLRDCLQCFFQQDALTWNNEIHCSFCETKQETAVRASISKAPKIIIFHLKRFDIQGTTKR 282

Query: 1294 KSQKIVKFPRESFDPSAFL 1312
            K +  + +P  + D + ++
Sbjct: 283  KLRTDIHYPLTNLDLTPYI 301



 Score = 33.1 bits (74), Expect = 2.2
 Identities = 14/26 (53%), Positives = 16/26 (61%)

Query: 1508 PIYNLYAISCHSGILGGGHYVTYAKN 1533
            P YNL A+  H G L GGHY  + KN
Sbjct: 309  PKYNLCAVVNHFGDLDGGHYTAFCKN 334


>gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens]
          Length = 525

 Score = 90.1 bits (222), Expect = 2e-17
 Identities = 76/286 (26%), Positives = 125/286 (43%), Gaps = 37/286 (12%)

Query: 638 YTGCFSRMQTIKEIHEYLSQRLRIKEEDMR---LWLYNSENYLTLLDDEDHKLEYLKIQD 694
           + GCF++    K IHE+   +      D+    ++ +  ++Y+    D+D ++   + Q 
Sbjct: 81  FFGCFTK----KHIHEHAKAKRHNLAIDLMYGGIYCFLCQDYIY---DKDMEIIAKEEQR 133

Query: 695 EQHLVIEVRNKDMSWP---EEMSFIANSSKIDRHKVPTEKGATGLSNLGNTCFMNSSIQC 751
           +   +  V  K  +W     E+  + ++ K  +       G  GL NLGNTCFMN  +Q 
Sbjct: 134 KAWKMQGVGEKFSTWEPTKRELELLKHNPKRRKITSNCTIGLRGLINLGNTCFMNCIVQA 193

Query: 752 VSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGTQKNVAPLKLRWTI 811
           +++T  L  +F+S RH  E+   +       +      L QE +SG +    P KL   +
Sbjct: 194 LTHTPLLRDFFLSDRHRCEMQSPSSC-----LVCEMSSLFQEFYSGHRSPHIPYKLLHLV 248

Query: 812 AKYAPRFNGFQQQDSQELLAFLLDGLHEDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNH 871
             +A    G++QQD+ E L   LD LH               D +G+           N+
Sbjct: 249 WTHARHLAGYEQQDAHEFLIAALDVLHRHCK----------GDDNGKK---------ANN 289

Query: 872 LRRNRSIVVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDS 917
                 I+  +F G L+S V C+ C  +S   DPF  +SL LP  S
Sbjct: 290 PNHCNCIIDQIFTGGLQSDVTCQVCHGVSTTIDPFWDISLDLPGSS 335



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 27/70 (38%), Positives = 36/70 (51%)

Query: 1235 LDSCLRAFTSEEELGENEMYYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQFVNGRWIK 1294
            L  CLR FT  E LG +    CS C ++  +TK+L + +LP +   HLKRF+       K
Sbjct: 362  LTDCLRRFTRPEHLGSSAKIKCSGCHSYQESTKQLTMKKLPIVACFHLKRFEHSAKLRRK 421

Query: 1295 SQKIVKFPRE 1304
                V FP E
Sbjct: 422  ITTYVSFPLE 431



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 21/82 (25%), Positives = 40/82 (48%), Gaps = 4/82 (4%)

Query: 1490 NHSEEDSTDDQREDTRIKPIYNLYAISCHSGILGGGHYVTYAKNPNCKWYCYNDSSCKEL 1549
            N   +  TD    D +    Y+L+A+  H G L  GHY ++ +    +W+  +D+   + 
Sbjct: 447  NGQYQQPTDSLNNDNK----YSLFAVVNHQGTLESGHYTSFIRQHKDQWFKCDDAIITKA 502

Query: 1550 HPDEIDTDSAYILFYEQQGIDY 1571
               ++     Y+LFY +Q ++Y
Sbjct: 503  SIKDVLDSEGYLLFYHKQFLEY 524


>gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens]
          Length = 828

 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 69/231 (29%), Positives = 106/231 (45%), Gaps = 23/231 (9%)

Query: 625 VPSPN--APLKRVLAYTGCFSRMQTIKEIHEYLSQR-LRIKEEDMRLWLY--NSENYLTL 679
           V  PN  A L+   +Y GC         IH   ++  L +    +R+W Y  + E +L  
Sbjct: 66  VQGPNLWACLENRCSYVGCGESQVDHSTIHSQETKHYLTVNLTTLRVWCYACSKEVFLDR 125

Query: 680 LDDEDHKLEYLKIQDEQHLVIEVRNKDMSWPEEMS--------FIANSSKIDRHKVPTEK 731
                  L +++   + H + E   +D   P   +        F     + D       +
Sbjct: 126 KLGTQPSLPHVR---QPHQIQENSVQDFKIPSNTTLKTPLVAVFDDLDIEADEEDELRAR 182

Query: 732 GATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLV 791
           G TGL N+GNTC+MN+++Q +SN  PLTQ+F+    L   ++      K  + K Y  L+
Sbjct: 183 GLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDK------KPAICKSYLKLM 236

Query: 792 QELWSGTQK-NVAPLKLRWTIAKYAPRFNGFQQQDSQELLAFLLDGLHEDL 841
            ELW  ++  +V P  L   I    P F G+ QQD+QE L  L+D LHE+L
Sbjct: 237 TELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEEL 287



 Score = 55.5 bits (132), Expect = 4e-07
 Identities = 33/86 (38%), Positives = 39/86 (45%)

Query: 1233 INLDSCLRAFTSEEELGENEMYYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQFVNGRW 1292
            + L  CL AF + +EL  + MY C KCK      K   +   P IL IHLKRF+      
Sbjct: 559  VTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFS 618

Query: 1293 IKSQKIVKFPRESFDPSAFLVPRDPA 1318
             K    V FP E  D   FL    PA
Sbjct: 619  TKISTHVSFPLEGLDLQPFLAKDSPA 644



 Score = 51.2 bits (121), Expect = 8e-06
 Identities = 21/58 (36%), Positives = 32/58 (55%), Gaps = 1/58 (1%)

Query: 1510 YNLYAISCHSGILGGGHYVTYAKNP-NCKWYCYNDSSCKELHPDEIDTDSAYILFYEQ 1566
            Y+L ++ CH G    GHY+ Y +N  N  WY ++D S  E+    +    AY+LFY +
Sbjct: 649  YDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRK 706



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 18/42 (42%), Positives = 28/42 (66%)

Query: 873 RRNRSIVVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLP 914
           ++ RS++ D+F G + S V+C TC  +SV  + F  LSLP+P
Sbjct: 469 KKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIP 510


>gi|42516567 ubiquitin specific protease 33 isoform 1 [Homo sapiens]
          Length = 942

 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 69/231 (29%), Positives = 106/231 (45%), Gaps = 23/231 (9%)

Query: 625 VPSPN--APLKRVLAYTGCFSRMQTIKEIHEYLSQR-LRIKEEDMRLWLY--NSENYLTL 679
           V  PN  A L+   +Y GC         IH   ++  L +    +R+W Y  + E +L  
Sbjct: 66  VQGPNLWACLENRCSYVGCGESQVDHSTIHSQETKHYLTVNLTTLRVWCYACSKEVFLDR 125

Query: 680 LDDEDHKLEYLKIQDEQHLVIEVRNKDMSWPEEMS--------FIANSSKIDRHKVPTEK 731
                  L +++   + H + E   +D   P   +        F     + D       +
Sbjct: 126 KLGTQPSLPHVR---QPHQIQENSVQDFKIPSNTTLKTPLVAVFDDLDIEADEEDELRAR 182

Query: 732 GATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLV 791
           G TGL N+GNTC+MN+++Q +SN  PLTQ+F+    L   ++      K  + K Y  L+
Sbjct: 183 GLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDK------KPAICKSYLKLM 236

Query: 792 QELWSGTQK-NVAPLKLRWTIAKYAPRFNGFQQQDSQELLAFLLDGLHEDL 841
            ELW  ++  +V P  L   I    P F G+ QQD+QE L  L+D LHE+L
Sbjct: 237 TELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEEL 287



 Score = 55.5 bits (132), Expect = 4e-07
 Identities = 33/86 (38%), Positives = 39/86 (45%)

Query: 1233 INLDSCLRAFTSEEELGENEMYYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQFVNGRW 1292
            + L  CL AF + +EL  + MY C KCK      K   +   P IL IHLKRF+      
Sbjct: 567  VTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFS 626

Query: 1293 IKSQKIVKFPRESFDPSAFLVPRDPA 1318
             K    V FP E  D   FL    PA
Sbjct: 627  TKISTHVSFPLEGLDLQPFLAKDSPA 652



 Score = 51.2 bits (121), Expect = 8e-06
 Identities = 21/58 (36%), Positives = 32/58 (55%), Gaps = 1/58 (1%)

Query: 1510 YNLYAISCHSGILGGGHYVTYAKNP-NCKWYCYNDSSCKELHPDEIDTDSAYILFYEQ 1566
            Y+L ++ CH G    GHY+ Y +N  N  WY ++D S  E+    +    AY+LFY +
Sbjct: 657  YDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRK 714



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 18/42 (42%), Positives = 28/42 (66%)

Query: 873 RRNRSIVVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLP 914
           ++ RS++ D+F G + S V+C TC  +SV  + F  LSLP+P
Sbjct: 469 KKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIP 510


>gi|42516565 ubiquitin specific protease 33 isoform 2 [Homo sapiens]
          Length = 911

 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 69/231 (29%), Positives = 106/231 (45%), Gaps = 23/231 (9%)

Query: 625 VPSPN--APLKRVLAYTGCFSRMQTIKEIHEYLSQR-LRIKEEDMRLWLY--NSENYLTL 679
           V  PN  A L+   +Y GC         IH   ++  L +    +R+W Y  + E +L  
Sbjct: 35  VQGPNLWACLENRCSYVGCGESQVDHSTIHSQETKHYLTVNLTTLRVWCYACSKEVFLDR 94

Query: 680 LDDEDHKLEYLKIQDEQHLVIEVRNKDMSWPEEMS--------FIANSSKIDRHKVPTEK 731
                  L +++   + H + E   +D   P   +        F     + D       +
Sbjct: 95  KLGTQPSLPHVR---QPHQIQENSVQDFKIPSNTTLKTPLVAVFDDLDIEADEEDELRAR 151

Query: 732 GATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLV 791
           G TGL N+GNTC+MN+++Q +SN  PLTQ+F+    L   ++      K  + K Y  L+
Sbjct: 152 GLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDK------KPAICKSYLKLM 205

Query: 792 QELWSGTQK-NVAPLKLRWTIAKYAPRFNGFQQQDSQELLAFLLDGLHEDL 841
            ELW  ++  +V P  L   I    P F G+ QQD+QE L  L+D LHE+L
Sbjct: 206 TELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEEL 256



 Score = 55.5 bits (132), Expect = 4e-07
 Identities = 33/86 (38%), Positives = 39/86 (45%)

Query: 1233 INLDSCLRAFTSEEELGENEMYYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQFVNGRW 1292
            + L  CL AF + +EL  + MY C KCK      K   +   P IL IHLKRF+      
Sbjct: 536  VTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFS 595

Query: 1293 IKSQKIVKFPRESFDPSAFLVPRDPA 1318
             K    V FP E  D   FL    PA
Sbjct: 596  TKISTHVSFPLEGLDLQPFLAKDSPA 621



 Score = 51.2 bits (121), Expect = 8e-06
 Identities = 21/58 (36%), Positives = 32/58 (55%), Gaps = 1/58 (1%)

Query: 1510 YNLYAISCHSGILGGGHYVTYAKNP-NCKWYCYNDSSCKELHPDEIDTDSAYILFYEQ 1566
            Y+L ++ CH G    GHY+ Y +N  N  WY ++D S  E+    +    AY+LFY +
Sbjct: 626  YDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRK 683



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 18/42 (42%), Positives = 28/42 (66%)

Query: 873 RRNRSIVVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLP 914
           ++ RS++ D+F G + S V+C TC  +SV  + F  LSLP+P
Sbjct: 438 KKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIP 479


>gi|183396780 ubiquitin specific protease 20 [Homo sapiens]
          Length = 914

 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 73/251 (29%), Positives = 106/251 (42%), Gaps = 40/251 (15%)

Query: 625 VPSPN--APLKRVLAYTGCFSRMQTIKEIHEYLSQR-LRIKEEDMRLWLYNSENYLTLLD 681
           V  PN  A L+    Y GC         IH    +  L +     RLW Y  E  + L  
Sbjct: 35  VTGPNLWACLQVACPYVGCGESFADHSTIHAQAKKHNLTVNLTTFRLWCYACEKEVFL-- 92

Query: 682 DEDHKLEYLKIQDEQHLVIEVRNKDMSWPEEMS------------FIANSSKIDRHKVPT 729
                        EQ L   +      + E+ S             +A+  + +      
Sbjct: 93  -------------EQRLAAPLLGSSSKFSEQDSPPPSHPLKAVPIAVADEGESESEDDDL 139

Query: 730 E-KGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYG 788
           + +G TG+ NLGN+C+MN+++Q +SN  PLTQ+F+    L   ++      K  + K Y 
Sbjct: 140 KPRGLTGMKNLGNSCYMNAALQALSNCPPLTQFFLECGGLVRTDK------KPALCKSYQ 193

Query: 789 DLVQELWSGTQKN-VAPLKLRWTIAKYAPRFNGFQQQDSQELLAFLLDGLHEDLNR--VH 845
            LV E+W   + + V P  L   I    P F G+ QQD+QE L  L+D LHE+L    V 
Sbjct: 194 KLVSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEELKEPVVA 253

Query: 846 EKPYVELKDSD 856
                E +DSD
Sbjct: 254 TVALTEARDSD 264



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 32/80 (40%), Positives = 40/80 (50%)

Query: 1233 INLDSCLRAFTSEEELGENEMYYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQFVNGRW 1292
            + L+ CL AF + +EL  + MY C +CK      K   + RLP IL IHLKRF+      
Sbjct: 537  VTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYS 596

Query: 1293 IKSQKIVKFPRESFDPSAFL 1312
             K    V FP E  D   FL
Sbjct: 597  FKINSHVSFPLEGLDLRPFL 616



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 21/58 (36%), Positives = 33/58 (56%), Gaps = 1/58 (1%)

Query: 1510 YNLYAISCHSGILGGGHYVTYAKNP-NCKWYCYNDSSCKELHPDEIDTDSAYILFYEQ 1566
            Y+L ++ CH G  G GHY+ Y +N  N +WY ++D    E+H   +     Y+LFY +
Sbjct: 627  YDLLSVICHHGTAGSGHYIAYCQNVINGQWYEFDDQYVTEVHETVVQNAEGYVLFYRK 684



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 18/42 (42%), Positives = 27/42 (64%)

Query: 873 RRNRSIVVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLP 914
           +R RS++ D+F G + S V+C TC  +S   + F  LSLP+P
Sbjct: 439 QRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIP 480


>gi|183397136 ubiquitin specific protease 20 [Homo sapiens]
          Length = 914

 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 73/251 (29%), Positives = 106/251 (42%), Gaps = 40/251 (15%)

Query: 625 VPSPN--APLKRVLAYTGCFSRMQTIKEIHEYLSQR-LRIKEEDMRLWLYNSENYLTLLD 681
           V  PN  A L+    Y GC         IH    +  L +     RLW Y  E  + L  
Sbjct: 35  VTGPNLWACLQVACPYVGCGESFADHSTIHAQAKKHNLTVNLTTFRLWCYACEKEVFL-- 92

Query: 682 DEDHKLEYLKIQDEQHLVIEVRNKDMSWPEEMS------------FIANSSKIDRHKVPT 729
                        EQ L   +      + E+ S             +A+  + +      
Sbjct: 93  -------------EQRLAAPLLGSSSKFSEQDSPPPSHPLKAVPIAVADEGESESEDDDL 139

Query: 730 E-KGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYG 788
           + +G TG+ NLGN+C+MN+++Q +SN  PLTQ+F+    L   ++      K  + K Y 
Sbjct: 140 KPRGLTGMKNLGNSCYMNAALQALSNCPPLTQFFLECGGLVRTDK------KPALCKSYQ 193

Query: 789 DLVQELWSGTQKN-VAPLKLRWTIAKYAPRFNGFQQQDSQELLAFLLDGLHEDLNR--VH 845
            LV E+W   + + V P  L   I    P F G+ QQD+QE L  L+D LHE+L    V 
Sbjct: 194 KLVSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEELKEPVVA 253

Query: 846 EKPYVELKDSD 856
                E +DSD
Sbjct: 254 TVALTEARDSD 264



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 32/80 (40%), Positives = 40/80 (50%)

Query: 1233 INLDSCLRAFTSEEELGENEMYYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQFVNGRW 1292
            + L+ CL AF + +EL  + MY C +CK      K   + RLP IL IHLKRF+      
Sbjct: 537  VTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYS 596

Query: 1293 IKSQKIVKFPRESFDPSAFL 1312
             K    V FP E  D   FL
Sbjct: 597  FKINSHVSFPLEGLDLRPFL 616



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 21/58 (36%), Positives = 33/58 (56%), Gaps = 1/58 (1%)

Query: 1510 YNLYAISCHSGILGGGHYVTYAKNP-NCKWYCYNDSSCKELHPDEIDTDSAYILFYEQ 1566
            Y+L ++ CH G  G GHY+ Y +N  N +WY ++D    E+H   +     Y+LFY +
Sbjct: 627  YDLLSVICHHGTAGSGHYIAYCQNVINGQWYEFDDQYVTEVHETVVQNAEGYVLFYRK 684



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 18/42 (42%), Positives = 27/42 (64%)

Query: 873 RRNRSIVVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLP 914
           +R RS++ D+F G + S V+C TC  +S   + F  LSLP+P
Sbjct: 439 QRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIP 480


>gi|183397134 ubiquitin specific protease 20 [Homo sapiens]
          Length = 914

 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 73/251 (29%), Positives = 106/251 (42%), Gaps = 40/251 (15%)

Query: 625 VPSPN--APLKRVLAYTGCFSRMQTIKEIHEYLSQR-LRIKEEDMRLWLYNSENYLTLLD 681
           V  PN  A L+    Y GC         IH    +  L +     RLW Y  E  + L  
Sbjct: 35  VTGPNLWACLQVACPYVGCGESFADHSTIHAQAKKHNLTVNLTTFRLWCYACEKEVFL-- 92

Query: 682 DEDHKLEYLKIQDEQHLVIEVRNKDMSWPEEMS------------FIANSSKIDRHKVPT 729
                        EQ L   +      + E+ S             +A+  + +      
Sbjct: 93  -------------EQRLAAPLLGSSSKFSEQDSPPPSHPLKAVPIAVADEGESESEDDDL 139

Query: 730 E-KGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYG 788
           + +G TG+ NLGN+C+MN+++Q +SN  PLTQ+F+    L   ++      K  + K Y 
Sbjct: 140 KPRGLTGMKNLGNSCYMNAALQALSNCPPLTQFFLECGGLVRTDK------KPALCKSYQ 193

Query: 789 DLVQELWSGTQKN-VAPLKLRWTIAKYAPRFNGFQQQDSQELLAFLLDGLHEDLNR--VH 845
            LV E+W   + + V P  L   I    P F G+ QQD+QE L  L+D LHE+L    V 
Sbjct: 194 KLVSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEELKEPVVA 253

Query: 846 EKPYVELKDSD 856
                E +DSD
Sbjct: 254 TVALTEARDSD 264



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 32/80 (40%), Positives = 40/80 (50%)

Query: 1233 INLDSCLRAFTSEEELGENEMYYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQFVNGRW 1292
            + L+ CL AF + +EL  + MY C +CK      K   + RLP IL IHLKRF+      
Sbjct: 537  VTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYS 596

Query: 1293 IKSQKIVKFPRESFDPSAFL 1312
             K    V FP E  D   FL
Sbjct: 597  FKINSHVSFPLEGLDLRPFL 616



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 21/58 (36%), Positives = 33/58 (56%), Gaps = 1/58 (1%)

Query: 1510 YNLYAISCHSGILGGGHYVTYAKNP-NCKWYCYNDSSCKELHPDEIDTDSAYILFYEQ 1566
            Y+L ++ CH G  G GHY+ Y +N  N +WY ++D    E+H   +     Y+LFY +
Sbjct: 627  YDLLSVICHHGTAGSGHYIAYCQNVINGQWYEFDDQYVTEVHETVVQNAEGYVLFYRK 684



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 18/42 (42%), Positives = 27/42 (64%)

Query: 873 RRNRSIVVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLP 914
           +R RS++ D+F G + S V+C TC  +S   + F  LSLP+P
Sbjct: 439 QRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIP 480


>gi|50312664 ubiquitin specific protease 16 isoform b [Homo sapiens]
          Length = 822

 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 84/310 (27%), Positives = 140/310 (45%), Gaps = 34/310 (10%)

Query: 638 YTGCFSRMQTIKEIHEYLSQR-----LRIKEEDMRLWLYNSENYLTLLDDED--HKLEYL 690
           + GC    Q    +  YL+ R     L +  ++  +W Y  +N +           ++Y+
Sbjct: 79  HQGCGRNSQEQHALKHYLTPRSEPHCLVLSLDNWSVWCYVCDNEVQYCSSNQLGQVVDYV 138

Query: 691 KIQ--------DEQHLVIEVRNKDMSWP----EEMSFIANSSKIDRH-KVPTEKGATGLS 737
           + Q        ++ +  IE+ NK +       +E     N +K +     P +    GLS
Sbjct: 139 RKQASITTPKPEKDNGNIELENKKLEKESKNEQEREKKENMAKENPPMNSPCQITVKGLS 198

Query: 738 NLGNTCFMNSSIQCVSNTQPLTQYF----ISGRHLY----ELNRTNPIGMK----GHMAK 785
           NLGNTCF N+ +Q +S T  L +      +SG  +     +L  T P+ +     G +  
Sbjct: 199 NLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLALTEPLEINLEPPGPLTL 258

Query: 786 CYGDLVQELWSGTQKNVAPLKLRWTIAKYAPRFNGFQQQDSQELLAFLLDGLH-EDLNRV 844
                + E+    +  V P +L   + K A RF G+QQQDSQELL +LLDG+  E+  RV
Sbjct: 259 AMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEHQRV 318

Query: 845 HEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIVVD-LFHGQLRSQVKCKTCGHISVRF 903
            +       +S  + D E+  +  D   +++    VD +F G+L S + C  C  +S+  
Sbjct: 319 SKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFGGELTSMIMCDQCRTVSLVH 378

Query: 904 DPFNFLSLPL 913
           + F  LSLP+
Sbjct: 379 ESFLDLSLPV 388



 Score = 39.3 bits (90), Expect = 0.031
 Identities = 23/88 (26%), Positives = 39/88 (44%), Gaps = 25/88 (28%)

Query: 1502 EDTRIKPIYNLYAISCHSGILGGGHYVTYAK-----------------------NPNCKW 1538
            E+TR+  +Y+LY +  HSG +  GHY  YAK                           +W
Sbjct: 735  ENTRV--LYSLYGVVEHSGTMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQW 792

Query: 1539 YCYNDSSCKELHPDEIDTDSAYILFYEQ 1566
            +  +D+  + +   ++    AY+LFYE+
Sbjct: 793  FHISDTHVQAVPTTKVLNSQAYLLFYER 820



 Score = 38.9 bits (89), Expect = 0.040
 Identities = 32/115 (27%), Positives = 42/115 (36%), Gaps = 22/115 (19%)

Query: 1210 TSQERVVDEHESVEQSRRAQAEPINLDSC-----LRAFTSEEELGENEMYYCSKCK---- 1260
            T    VV+E         A  E  N D C     L  FT  E+L +     C  C     
Sbjct: 602  TKVYEVVNEDPETAFCTLANREVFNTDECSIQHCLYQFTRNEKLRDANKLLCEVCTRRQC 661

Query: 1261 -------------THCLATKKLDLWRLPPILIIHLKRFQFVNGRWIKSQKIVKFP 1302
                          +  A K++ +   PP+L +HLKRFQ       K  K +KFP
Sbjct: 662  NGPKANIKGERKHVYTNAKKQMLISLAPPVLTLHLKRFQQAGFNLRKVNKHIKFP 716


>gi|5454156 ubiquitin specific protease 16 isoform a [Homo sapiens]
          Length = 823

 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 65/200 (32%), Positives = 100/200 (50%), Gaps = 14/200 (7%)

Query: 728 PTEKGATGLSNLGNTCFMNSSIQCVSNTQPLTQYF----ISGRHLY----ELNRTNPIGM 779
           P +    GLSNLGNTCF N+ +Q +S T  L +      +SG  +     +L  T P+ +
Sbjct: 190 PCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLALTEPLEI 249

Query: 780 K----GHMAKCYGDLVQELWSGTQKNVAPLKLRWTIAKYAPRFNGFQQQDSQELLAFLLD 835
                G +       + E+    +  V P +L   + K A RF G+QQQDSQELL +LLD
Sbjct: 250 NLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLD 309

Query: 836 GLH-EDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIVVD-LFHGQLRSQVKC 893
           G+  E+  RV +       +S  + D E+  +  D   +++    VD +F G+L S + C
Sbjct: 310 GMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFGGELTSMIMC 369

Query: 894 KTCGHISVRFDPFNFLSLPL 913
             C  +S+  + F  LSLP+
Sbjct: 370 DQCRTVSLVHESFLDLSLPV 389



 Score = 39.3 bits (90), Expect = 0.031
 Identities = 23/88 (26%), Positives = 39/88 (44%), Gaps = 25/88 (28%)

Query: 1502 EDTRIKPIYNLYAISCHSGILGGGHYVTYAK-----------------------NPNCKW 1538
            E+TR+  +Y+LY +  HSG +  GHY  YAK                           +W
Sbjct: 736  ENTRV--LYSLYGVVEHSGTMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQW 793

Query: 1539 YCYNDSSCKELHPDEIDTDSAYILFYEQ 1566
            +  +D+  + +   ++    AY+LFYE+
Sbjct: 794  FHISDTHVQAVPTTKVLNSQAYLLFYER 821



 Score = 38.9 bits (89), Expect = 0.040
 Identities = 32/115 (27%), Positives = 42/115 (36%), Gaps = 22/115 (19%)

Query: 1210 TSQERVVDEHESVEQSRRAQAEPINLDSC-----LRAFTSEEELGENEMYYCSKCK---- 1260
            T    VV+E         A  E  N D C     L  FT  E+L +     C  C     
Sbjct: 603  TKVYEVVNEDPETAFCTLANREVFNTDECSIQHCLYQFTRNEKLRDANKLLCEVCTRRQC 662

Query: 1261 -------------THCLATKKLDLWRLPPILIIHLKRFQFVNGRWIKSQKIVKFP 1302
                          +  A K++ +   PP+L +HLKRFQ       K  K +KFP
Sbjct: 663  NGPKANIKGERKHVYTNAKKQMLISLAPPVLTLHLKRFQQAGFNLRKVNKHIKFP 717


>gi|75992941 ubiquitin specific protease 16 isoform a [Homo sapiens]
          Length = 823

 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 65/200 (32%), Positives = 100/200 (50%), Gaps = 14/200 (7%)

Query: 728 PTEKGATGLSNLGNTCFMNSSIQCVSNTQPLTQYF----ISGRHLY----ELNRTNPIGM 779
           P +    GLSNLGNTCF N+ +Q +S T  L +      +SG  +     +L  T P+ +
Sbjct: 190 PCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLALTEPLEI 249

Query: 780 K----GHMAKCYGDLVQELWSGTQKNVAPLKLRWTIAKYAPRFNGFQQQDSQELLAFLLD 835
                G +       + E+    +  V P +L   + K A RF G+QQQDSQELL +LLD
Sbjct: 250 NLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLD 309

Query: 836 GLH-EDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIVVD-LFHGQLRSQVKC 893
           G+  E+  RV +       +S  + D E+  +  D   +++    VD +F G+L S + C
Sbjct: 310 GMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFGGELTSMIMC 369

Query: 894 KTCGHISVRFDPFNFLSLPL 913
             C  +S+  + F  LSLP+
Sbjct: 370 DQCRTVSLVHESFLDLSLPV 389



 Score = 39.3 bits (90), Expect = 0.031
 Identities = 23/88 (26%), Positives = 39/88 (44%), Gaps = 25/88 (28%)

Query: 1502 EDTRIKPIYNLYAISCHSGILGGGHYVTYAK-----------------------NPNCKW 1538
            E+TR+  +Y+LY +  HSG +  GHY  YAK                           +W
Sbjct: 736  ENTRV--LYSLYGVVEHSGTMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQW 793

Query: 1539 YCYNDSSCKELHPDEIDTDSAYILFYEQ 1566
            +  +D+  + +   ++    AY+LFYE+
Sbjct: 794  FHISDTHVQAVPTTKVLNSQAYLLFYER 821



 Score = 38.9 bits (89), Expect = 0.040
 Identities = 32/115 (27%), Positives = 42/115 (36%), Gaps = 22/115 (19%)

Query: 1210 TSQERVVDEHESVEQSRRAQAEPINLDSC-----LRAFTSEEELGENEMYYCSKCK---- 1260
            T    VV+E         A  E  N D C     L  FT  E+L +     C  C     
Sbjct: 603  TKVYEVVNEDPETAFCTLANREVFNTDECSIQHCLYQFTRNEKLRDANKLLCEVCTRRQC 662

Query: 1261 -------------THCLATKKLDLWRLPPILIIHLKRFQFVNGRWIKSQKIVKFP 1302
                          +  A K++ +   PP+L +HLKRFQ       K  K +KFP
Sbjct: 663  NGPKANIKGERKHVYTNAKKQMLISLAPPVLTLHLKRFQQAGFNLRKVNKHIKFP 717


>gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens]
          Length = 438

 Score = 79.3 bits (194), Expect = 3e-14
 Identities = 59/188 (31%), Positives = 86/188 (45%), Gaps = 34/188 (18%)

Query: 732 GATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLV 791
           G  GL NLGNTCFMN  +Q +++T  L  +F+S RH  E+  +  + +   M+     L 
Sbjct: 76  GLRGLINLGNTCFMNCIVQALTHTPILRDFFLSDRHRCEM-PSPELCLVCEMS----SLF 130

Query: 792 QELWSGTQKNVAPLKLRWTIAKYAPRFNGFQQQDSQELLAFLLDGLH-----EDLNRVHE 846
           +EL+SG      P KL   +  +A    G++QQD+ E L   LD LH     +D+ +   
Sbjct: 131 RELYSGNPSPHVPYKLLHLVWIHARHLAGYRQQDAHEFLIAALDVLHRHCKGDDVGKAAN 190

Query: 847 KPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIVVDLFHGQLRSQVKCKTCGHISVRFDPF 906
            P                     NH      I+  +F G L+S V C+ C  +S   DP 
Sbjct: 191 NP---------------------NHC---NCIIDQIFTGGLQSDVTCQACHGVSTTIDPC 226

Query: 907 NFLSLPLP 914
             +SL LP
Sbjct: 227 WDISLDLP 234



 Score = 48.5 bits (114), Expect = 5e-05
 Identities = 24/70 (34%), Positives = 36/70 (51%)

Query: 1235 LDSCLRAFTSEEELGENEMYYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQFVNGRWIK 1294
            L  CLR FT  E LG +    C  C+++  +TK+L + +LP +   H KRF+    +  K
Sbjct: 263  LTDCLRRFTRPEHLGSSAKIKCGSCQSYQESTKQLTMNKLPVVACFHFKRFEHSAKQRRK 322

Query: 1295 SQKIVKFPRE 1304
                + FP E
Sbjct: 323  ITTYISFPLE 332



 Score = 42.4 bits (98), Expect = 0.004
 Identities = 16/62 (25%), Positives = 35/62 (56%)

Query: 1510 YNLYAISCHSGILGGGHYVTYAKNPNCKWYCYNDSSCKELHPDEIDTDSAYILFYEQQGI 1569
            Y+L+A+  H G L  GHY ++ ++   +W+  +D+   +    ++     Y+LFY +Q +
Sbjct: 364  YSLFAVVNHQGTLESGHYTSFIRHHKDQWFKCDDAVITKASIKDVLDSEGYLLFYHKQVL 423

Query: 1570 DY 1571
            ++
Sbjct: 424  EH 425


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.135    0.413 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 66,051,888
Number of Sequences: 37866
Number of extensions: 3253855
Number of successful extensions: 11096
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 169
Number of HSP's successfully gapped in prelim test: 101
Number of HSP's that attempted gapping in prelim test: 10126
Number of HSP's gapped (non-prelim): 861
length of query: 1604
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1488
effective length of database: 13,855,062
effective search space: 20616332256
effective search space used: 20616332256
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.