BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|115495443 WD repeat domain 64 [Homo sapiens] (634 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|115495443 WD repeat domain 64 [Homo sapiens] 1284 0.0 gi|221139921 EF-hand calcium binding domain 8 [Homo sapiens] 119 7e-27 gi|30520335 WD repeat domain 49 [Homo sapiens] 108 1e-23 gi|32189425 WD repeat domain 69 [Homo sapiens] 60 5e-09 gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Hom... 59 1e-08 gi|34996489 pleckstrin homology domain interacting protein [Homo... 59 1e-08 gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 57 7e-08 gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 57 7e-08 gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 57 7e-08 gi|16445438 bromodomain and WD repeat domain containing 1 isofor... 55 2e-07 gi|16445436 bromodomain and WD repeat domain containing 1 isofor... 55 2e-07 gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 52 2e-06 gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 52 2e-06 gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 52 2e-06 gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 52 2e-06 gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa... 51 4e-06 gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 50 6e-06 gi|153791630 bromodomain and WD repeat domain containing 3 [Homo... 50 8e-06 gi|21536371 telomerase-associated protein 1 [Homo sapiens] 49 1e-05 gi|4502477 beta-transducin repeat containing protein isoform 2 [... 49 1e-05 gi|16117783 beta-transducin repeat containing protein isoform 1 ... 49 1e-05 gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 48 2e-05 gi|51242945 striatin, calmodulin binding protein [Homo sapiens] 48 2e-05 gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 47 4e-05 gi|23199987 WD repeat domain 5B [Homo sapiens] 47 4e-05 gi|62234438 Notchless gene homolog isoform b [Homo sapiens] 47 4e-05 gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 47 4e-05 gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 47 5e-05 gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 47 5e-05 gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 47 5e-05 >gi|115495443 WD repeat domain 64 [Homo sapiens] Length = 634 Score = 1284 bits (3323), Expect = 0.0 Identities = 634/634 (100%), Positives = 634/634 (100%) Query: 1 MKIRYISALNCFGSCSLDSNHSLVLESLKRLEDNLPVREFSMPRGANTFCYCVKANVIVT 60 MKIRYISALNCFGSCSLDSNHSLVLESLKRLEDNLPVREFSMPRGANTFCYCVKANVIVT Sbjct: 1 MKIRYISALNCFGSCSLDSNHSLVLESLKRLEDNLPVREFSMPRGANTFCYCVKANVIVT 60 Query: 61 GGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSL 120 GGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSL Sbjct: 61 GGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSL 120 Query: 121 LQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTKQVPHTHEREINV 180 LQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTKQVPHTHEREINV Sbjct: 121 LQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTKQVPHTHEREINV 180 Query: 181 MLYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAY 240 MLYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAY Sbjct: 181 MLYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAY 240 Query: 241 NGTVRIWDFGSGQEMKVLPEGKDWKEDEHCLRRLIFLKAQEKHQQLVLALERNGTIKMIQ 300 NGTVRIWDFGSGQEMKVLPEGKDWKEDEHCLRRLIFLKAQEKHQQLVLALERNGTIKMIQ Sbjct: 241 NGTVRIWDFGSGQEMKVLPEGKDWKEDEHCLRRLIFLKAQEKHQQLVLALERNGTIKMIQ 300 Query: 301 GKEDDIYLMVIWELPDVVPFLQDGKHAVHLRMSTRDRNMAIPFPDVELIVERNFSQPTDN 360 GKEDDIYLMVIWELPDVVPFLQDGKHAVHLRMSTRDRNMAIPFPDVELIVERNFSQPTDN Sbjct: 301 GKEDDIYLMVIWELPDVVPFLQDGKHAVHLRMSTRDRNMAIPFPDVELIVERNFSQPTDN 360 Query: 361 PTMDLLRVNCIDLLQVEGYNLIAAGTLNEGHVILCNISSFLDPPHDEKKFKQLLSWRAHS 420 PTMDLLRVNCIDLLQVEGYNLIAAGTLNEGHVILCNISSFLDPPHDEKKFKQLLSWRAHS Sbjct: 361 PTMDLLRVNCIDLLQVEGYNLIAAGTLNEGHVILCNISSFLDPPHDEKKFKQLLSWRAHS 420 Query: 421 LEIIQVIYVEEKQVVLTASIDGSVRLWHALNGHYCGYFGQRRLFELSQTRDFILPCDVTE 480 LEIIQVIYVEEKQVVLTASIDGSVRLWHALNGHYCGYFGQRRLFELSQTRDFILPCDVTE Sbjct: 421 LEIIQVIYVEEKQVVLTASIDGSVRLWHALNGHYCGYFGQRRLFELSQTRDFILPCDVTE 480 Query: 481 YPIEIKEESKFTEKQKYEYPLIFDREKWRKMSSVSLLFKRTPPKAFEVEQDFKFFKSLSS 540 YPIEIKEESKFTEKQKYEYPLIFDREKWRKMSSVSLLFKRTPPKAFEVEQDFKFFKSLSS Sbjct: 481 YPIEIKEESKFTEKQKYEYPLIFDREKWRKMSSVSLLFKRTPPKAFEVEQDFKFFKSLSS 540 Query: 541 PKIRRYPLEGFVTENREAGIVFGSLPIYSISSPTSLRFLPLIGVEAQKDSSDGITGKKKG 600 PKIRRYPLEGFVTENREAGIVFGSLPIYSISSPTSLRFLPLIGVEAQKDSSDGITGKKKG Sbjct: 541 PKIRRYPLEGFVTENREAGIVFGSLPIYSISSPTSLRFLPLIGVEAQKDSSDGITGKKKG 600 Query: 601 GHVQREKAPRRRSLKKNLVPQINLASSFFPAIPK 634 GHVQREKAPRRRSLKKNLVPQINLASSFFPAIPK Sbjct: 601 GHVQREKAPRRRSLKKNLVPQINLASSFFPAIPK 634 >gi|221139921 EF-hand calcium binding domain 8 [Homo sapiens] Length = 1288 Score = 119 bits (299), Expect = 7e-27 Identities = 79/264 (29%), Positives = 131/264 (49%), Gaps = 8/264 (3%) Query: 2 KIRYISALNCFGSCSLDSNHSLVLESLKRLEDNLP-VREFSMPRGANTFCYCVKANVIVT 60 ++++I +N SCS SLVL L P + + +G F YC N +VT Sbjct: 328 QVKFIPQMNVVVSCSAIEKSSLVLTILPAKASKKPRLSVLRLRKGILCFDYCPDRNFLVT 387 Query: 61 GGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHV-VSLSSAKVFRVWDIQTLS 119 GG D IRLW+P +S +PV + GH S+ I+ + ++ + +S+S K RVWD+ Sbjct: 388 GGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILVDSRNNSILISVSKDKNIRVWDMLDYI 447 Query: 120 LLQVFHDSQGGPGDMQIYSMIYDANHGMLITGS---SVMDMYPLTR-MIQDTKQVPHTHE 175 LQ F G+ I S + LI + ++ Y + +I+ K+ TH Sbjct: 448 CLQSFCGKFFALGNCPITSAYFFEKDNTLICSTYSIGILKGYLEAQGLIKARKRT--THC 505 Query: 176 REINVMLYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLF 235 + +LY+K F QV++ C + VWE+ TG + + G + E+T+ A+DES Sbjct: 506 SPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGRKTMEFAVSGGQHVEMTAMALDESERCL 565 Query: 236 ATGAYNGTVRIWDFGSGQEMKVLP 259 TG +GT+++W++ G+ + P Sbjct: 566 LTGLRDGTMKMWNYNIGKCLLTFP 589 Score = 37.0 bits (84), Expect = 0.056 Identities = 16/47 (34%), Positives = 28/47 (59%), Gaps = 1/47 (2%) Query: 413 LLSWRAHSLEIIQVIYVEEKQVVLTASIDGSVRLWHALNGHYCGYFG 459 L++W+ H + ++YV+ Q+V++A D V+ W L+G G FG Sbjct: 945 LMTWKGHLNSVADILYVDNFQLVISAGQDRDVKAW-KLSGDAIGTFG 990 >gi|30520335 WD repeat domain 49 [Homo sapiens] Length = 697 Score = 108 bits (271), Expect = 1e-23 Identities = 73/250 (29%), Positives = 126/250 (50%), Gaps = 8/250 (3%) Query: 29 KRLEDNLPVREFSMPRGANTFCYCVKANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFS 88 ++ + L + F++ +G + F Y + N+I T G + + LW+P + +KPVG L GH S Sbjct: 5 EKSKKRLNMTSFNIAQGIHAFDYHSRLNLIATAGINNKVCLWNPYVVSKPVGVLWGHSAS 64 Query: 89 IAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGML 148 + + + + + S S KV R+WDIQ +Q S D + +D HG L Sbjct: 65 VIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRIACSFPKSQDFRCL-FHFDEAHGRL 123 Query: 149 ITGSSVMDMYPLTRMIQDTKQVPHTHEREINVMLYNKYFHQVLTICSESIIRVWELETGL 208 S + L M + + +HE+ + +LYN QV++ + S + W ++TG Sbjct: 124 FI--SFNNQLALLAMKSEASKRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQ 181 Query: 209 QVYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDWKEDE 268 ++ Q HG N E+++ A+D + TG+ +GTV+IWDF +G L G+D D Sbjct: 182 KIKQFTGCHG-NAEISTMALDANETRLLTGSTDGTVKIWDF-NGYCHHTLNVGQDGAVD- 238 Query: 269 HCLRRLIFLK 278 + +++ LK Sbjct: 239 --ISQILILK 246 >gi|32189425 WD repeat domain 69 [Homo sapiens] Length = 415 Score = 60.5 bits (145), Expect = 5e-09 Identities = 48/190 (25%), Positives = 82/190 (43%), Gaps = 9/190 (4%) Query: 58 IVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQT 117 I+TG D + +W + K V L+GH I+ N +++ S K ++WD Sbjct: 234 IITGSFDHTVVVWDADTGRK-VNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATN 292 Query: 118 LSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTKQVPHTHERE 177 + D +I +D ++ T S+ + + HE E Sbjct: 293 GKCVATLTGH-----DDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGE 347 Query: 178 INVMLYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFAT 237 I+ + +N + +LT S+ R+W+ +TG Q Q+LE H E+ S A + G + T Sbjct: 348 ISKISFNPQGNHLLTGSSDKTARIWDAQTG-QCLQVLEGH--TDEIFSCAFNYKGNIVIT 404 Query: 238 GAYNGTVRIW 247 G+ + T RIW Sbjct: 405 GSKDNTCRIW 414 Score = 53.1 bits (126), Expect = 7e-07 Identities = 38/180 (21%), Positives = 82/180 (45%), Gaps = 13/180 (7%) Query: 82 LVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIY 141 L H+ + + N+ ++ S + ++WD + L + +Y++ + Sbjct: 88 LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRN-----VVYAIAF 142 Query: 142 DANHGMLITGSSVMDMYPLTRMIQDTKQVPHT---HEREINVMLYNKYFHQVLTICSESI 198 + +G I S L + +T + HT H EI + +N V T ++ Sbjct: 143 NNPYGDKIATGSFDKTCKLWSV--ETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTT 200 Query: 199 IRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMKVL 258 ++W+++ G +VY + G + E+ S + + SG TG+++ TV +WD +G+++ +L Sbjct: 201 AKLWDIQNGEEVYTL---RGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNIL 257 Score = 48.5 bits (114), Expect = 2e-05 Identities = 33/103 (32%), Positives = 52/103 (50%), Gaps = 6/103 (5%) Query: 50 CYCVKANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKV 109 C+ +I T D R++ + K + KL GH I++I N + H+++ SS K Sbjct: 310 CFDYTGKLIATASADGTARIFSA-ATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKT 368 Query: 110 FRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGS 152 R+WD QT LQV G D +I+S ++ ++ITGS Sbjct: 369 ARIWDAQTGQCLQVLE----GHTD-EIFSCAFNYKGNIVITGS 406 Score = 41.6 bits (96), Expect = 0.002 Identities = 64/303 (21%), Positives = 104/303 (34%), Gaps = 70/303 (23%) Query: 8 ALNCFGSCSLDSNHSLVLESLKRLEDNLPVREFSMPRGANTFCYCVKAN-----VIVTGG 62 ALN GSC + ++ +L D E + G Y + N I TG Sbjct: 99 ALNKSGSCFITGSYDRTC----KLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGS 154 Query: 63 DDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSLLQ 122 DK +LW K GH I + N + V + S ++WDIQ + Sbjct: 155 FDKTCKLWSVETG-KCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVY 213 Query: 123 VFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTK-----QVPHTHERE 177 +I S+ ++ + +ITGS + T ++ D + H E Sbjct: 214 TLRGHSA-----EIISLSFNTSGDRIITGS-----FDHTVVVWDADTGRKVNILIGHCAE 263 Query: 178 INVMLYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFAT 237 I+ +N +LT + ++W+ G V + G + E+ + D +G L AT Sbjct: 264 ISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLT---GHDDEILDSCFDYTGKLIAT 320 Query: 238 GAYNGTVRI------------------------------------------WDFGSGQEM 255 + +GT RI WD +GQ + Sbjct: 321 ASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCL 380 Query: 256 KVL 258 +VL Sbjct: 381 QVL 383 Score = 40.8 bits (94), Expect = 0.004 Identities = 51/245 (20%), Positives = 93/245 (37%), Gaps = 37/245 (15%) Query: 210 VYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDWKEDEH 269 ++++L+ H +T+ A+++SG F TG+Y+ T ++WD SG+E+ L Sbjct: 84 LFKVLKAHIL--PLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTL----------- 130 Query: 270 CLRRLIFLKAQEKHQQLVLALERNGTI--KMIQGKEDDIYLMVIWELPDVVPFLQDGKHA 327 E H+ +V A+ N K+ G D +W ++ GK Sbjct: 131 -----------EGHRNVVYAIAFNNPYGDKIATGSFDK--TCKLWS-------VETGK-C 169 Query: 328 VHLRMSTRDRNMAIPFPDVELIVERNFSQPTDNPTMDLLRVNCIDLLQVEGYNLIAAGTL 387 H + + F +V S T D+ + L+ +I+ Sbjct: 170 YHTFRGHTAEIVCLSFNPQSTLVATG-SMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFN 228 Query: 388 NEGHVILCNISSFLDPPHDEKKFKQLLSWRAHSLEIIQVIYVEEKQVVLTASIDGSVRLW 447 G I+ D +++ H EI + + ++LT S+D + +LW Sbjct: 229 TSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLW 288 Query: 448 HALNG 452 A NG Sbjct: 289 DATNG 293 >gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Homo sapiens] Length = 504 Score = 59.3 bits (142), Expect = 1e-08 Identities = 65/295 (22%), Positives = 118/295 (40%), Gaps = 41/295 (13%) Query: 56 NVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDI 115 N I+TGG DK + ++ + S + + L GH + +V + V S S R+W + Sbjct: 235 NKILTGGADKNVVVFDKS-SEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSV 293 Query: 116 QTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTKQVPHTHE 175 S +QV + + ++ A L++ S D Y IQ + + + Sbjct: 294 PNASCVQVVRAHESAVTGLSLH-----ATGDYLLSSSD--DQYWAFSDIQTGRVLTKVTD 346 Query: 176 REINVMLYNKYFHQVLTICS----ESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDES 231 L FH I +S I++W+L+ V G + +TS A E+ Sbjct: 347 ETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANF---PGHSGPITSIAFSEN 403 Query: 232 GFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDWKEDEHCLRRLIFLKAQEKHQQLVLALE 291 G+ AT A + +V++WD + K L +++ ++ LIF + Sbjct: 404 GYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFE-----VKSLIF--------------D 444 Query: 292 RNGTIKMIQGKEDDIYLMVIW-------ELPDVVPFLQDGKHAVHLRMSTRDRNM 339 ++GT + G + IY+ W E + + G HA + + DR++ Sbjct: 445 QSGTYLALGGTDVQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSL 499 >gi|34996489 pleckstrin homology domain interacting protein [Homo sapiens] Length = 1821 Score = 58.9 bits (141), Expect = 1e-08 Identities = 60/288 (20%), Positives = 121/288 (42%), Gaps = 31/288 (10%) Query: 51 YCVK----ANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSS 106 YCV I TG DD ++++W + + + L GH I+++ N ++ + + S Sbjct: 187 YCVTFDRTGRRIFTGSDDCLVKIWATD-DGRLLATLRGHAAEISDMAVNYENTMIAAGSC 245 Query: 107 AKVFRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSS---VMDMYPLTRM 163 K+ RVW ++T + L V +Q + + + TG+ ++ + Sbjct: 246 DKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFWLWDAGTL 305 Query: 164 IQDTKQVPHTHEREINVMLYNKYFHQ----VLTICSESIIRVWELETGLQVYQILEPHGF 219 + + T V + F + T ++ IIRV+ +G Q +I E Sbjct: 306 KINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSG-QPEKISELEFH 364 Query: 220 NTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQ------EMKVLPEGKDWKEDEHCLRR 273 +V S + F +G+ +GT RIW F + +M P G++ + E + + Sbjct: 365 TDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSILLDMATRPAGQNLQGIEDKITK 424 Query: 274 L-IFLKAQEKHQQLVLALERNGTIK-----------MIQGKEDDIYLM 309 + + + A ++H V+ N T+K ++ G ED+++++ Sbjct: 425 MKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVL 472 >gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo sapiens] Length = 589 Score = 56.6 bits (135), Expect = 7e-08 Identities = 56/250 (22%), Positives = 112/250 (44%), Gaps = 34/250 (13%) Query: 53 VKANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRV 112 ++ N+I++G D+ +++W+ + + L GH ++ + +EK VVS S RV Sbjct: 311 MRDNIIISGSTDRTLKVWNAETG-ECIHTLYGHTSTVRCMHLHEK--RVVSGSRDATLRV 367 Query: 113 WDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQD--TKQV 170 WDI+T L V +Q YD +++G+ Y + D T+ Sbjct: 368 WDIETGQCLHVLMGHVAAVRCVQ-----YDGRR--VVSGA-----YDFMVKVWDPETETC 415 Query: 171 PHTHEREINVMLYNKYFHQVLTICS--ESIIRVWELETGLQVYQILEPHGFNTEVTSAAV 228 HT + N +Y+ F + + ++ IRVW++ETG ++ + + ++ + Sbjct: 416 LHTLQGHTN-RVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLT-----GHQSLTSGM 469 Query: 229 DESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDWKEDEHCLRRLIFLKAQEKHQQLVL 288 + + +G + TV+IWD +GQ ++ L + CL + ++ V+ Sbjct: 470 ELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCL---------QFNKNFVI 520 Query: 289 ALERNGTIKM 298 +GT+K+ Sbjct: 521 TSSDDGTVKL 530 Score = 38.9 bits (89), Expect = 0.015 Identities = 50/266 (18%), Positives = 113/266 (42%), Gaps = 44/266 (16%) Query: 190 VLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIWDF 249 +++ ++ ++VW ETG ++ + +G + V + E + +G+ + T+R+WD Sbjct: 316 IISGSTDRTLKVWNAETGECIHTL---YGHTSTVRCMHLHEKRVV--SGSRDATLRVWDI 370 Query: 250 GSGQEMKVLPEGKDWKEDEHCLRRLIFLKAQEKHQQLVLALERNGTIKMIQGKEDDIYLM 309 +GQ CL L+ H V ++ +G +++ G D +++ Sbjct: 371 ETGQ----------------CLHVLM------GHVAAVRCVQYDGR-RVVSGAYD--FMV 405 Query: 310 VIWELPDVVPFLQDGKHAVHLRMSTRDRNMAIPFPDVELIVERNFSQPTDNPTMDLLRVN 369 +W+ + + +H +R ++ F + ++ + S T D+ N Sbjct: 406 KVWD--------PETETCLHTLQGHTNRVYSLQFDGIHVV---SGSLDTSIRVWDVETGN 454 Query: 370 CIDLLQVEGYNLIAAGTLNEGHVILCNISSFLDPPHDEKKFKQLLSWRAHSLEIIQVIYV 429 CI L G+ + +G + ++++ + D K + L + + + V + Sbjct: 455 CIHTLT--GHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCL 512 Query: 430 E-EKQVVLTASIDGSVRLWHALNGHY 454 + K V+T+S DG+V+LW G + Sbjct: 513 QFNKNFVITSSDDGTVKLWDLKTGEF 538 >gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo sapiens] Length = 707 Score = 56.6 bits (135), Expect = 7e-08 Identities = 56/250 (22%), Positives = 112/250 (44%), Gaps = 34/250 (13%) Query: 53 VKANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRV 112 ++ N+I++G D+ +++W+ + + L GH ++ + +EK VVS S RV Sbjct: 429 MRDNIIISGSTDRTLKVWNAETG-ECIHTLYGHTSTVRCMHLHEK--RVVSGSRDATLRV 485 Query: 113 WDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQD--TKQV 170 WDI+T L V +Q YD +++G+ Y + D T+ Sbjct: 486 WDIETGQCLHVLMGHVAAVRCVQ-----YDGRR--VVSGA-----YDFMVKVWDPETETC 533 Query: 171 PHTHEREINVMLYNKYFHQVLTICS--ESIIRVWELETGLQVYQILEPHGFNTEVTSAAV 228 HT + N +Y+ F + + ++ IRVW++ETG ++ + + ++ + Sbjct: 534 LHTLQGHTN-RVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLT-----GHQSLTSGM 587 Query: 229 DESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDWKEDEHCLRRLIFLKAQEKHQQLVL 288 + + +G + TV+IWD +GQ ++ L + CL + ++ V+ Sbjct: 588 ELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCL---------QFNKNFVI 638 Query: 289 ALERNGTIKM 298 +GT+K+ Sbjct: 639 TSSDDGTVKL 648 Score = 38.9 bits (89), Expect = 0.015 Identities = 50/266 (18%), Positives = 113/266 (42%), Gaps = 44/266 (16%) Query: 190 VLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIWDF 249 +++ ++ ++VW ETG ++ + +G + V + E + +G+ + T+R+WD Sbjct: 434 IISGSTDRTLKVWNAETGECIHTL---YGHTSTVRCMHLHEKRVV--SGSRDATLRVWDI 488 Query: 250 GSGQEMKVLPEGKDWKEDEHCLRRLIFLKAQEKHQQLVLALERNGTIKMIQGKEDDIYLM 309 +GQ CL L+ H V ++ +G +++ G D +++ Sbjct: 489 ETGQ----------------CLHVLM------GHVAAVRCVQYDGR-RVVSGAYD--FMV 523 Query: 310 VIWELPDVVPFLQDGKHAVHLRMSTRDRNMAIPFPDVELIVERNFSQPTDNPTMDLLRVN 369 +W+ + + +H +R ++ F + ++ + S T D+ N Sbjct: 524 KVWD--------PETETCLHTLQGHTNRVYSLQFDGIHVV---SGSLDTSIRVWDVETGN 572 Query: 370 CIDLLQVEGYNLIAAGTLNEGHVILCNISSFLDPPHDEKKFKQLLSWRAHSLEIIQVIYV 429 CI L G+ + +G + ++++ + D K + L + + + V + Sbjct: 573 CIHTLT--GHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCL 630 Query: 430 E-EKQVVLTASIDGSVRLWHALNGHY 454 + K V+T+S DG+V+LW G + Sbjct: 631 QFNKNFVITSSDDGTVKLWDLKTGEF 656 >gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo sapiens] Length = 627 Score = 56.6 bits (135), Expect = 7e-08 Identities = 56/250 (22%), Positives = 112/250 (44%), Gaps = 34/250 (13%) Query: 53 VKANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRV 112 ++ N+I++G D+ +++W+ + + L GH ++ + +EK VVS S RV Sbjct: 349 MRDNIIISGSTDRTLKVWNAETG-ECIHTLYGHTSTVRCMHLHEK--RVVSGSRDATLRV 405 Query: 113 WDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQD--TKQV 170 WDI+T L V +Q YD +++G+ Y + D T+ Sbjct: 406 WDIETGQCLHVLMGHVAAVRCVQ-----YDGRR--VVSGA-----YDFMVKVWDPETETC 453 Query: 171 PHTHEREINVMLYNKYFHQVLTICS--ESIIRVWELETGLQVYQILEPHGFNTEVTSAAV 228 HT + N +Y+ F + + ++ IRVW++ETG ++ + + ++ + Sbjct: 454 LHTLQGHTN-RVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLT-----GHQSLTSGM 507 Query: 229 DESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDWKEDEHCLRRLIFLKAQEKHQQLVL 288 + + +G + TV+IWD +GQ ++ L + CL + ++ V+ Sbjct: 508 ELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCL---------QFNKNFVI 558 Query: 289 ALERNGTIKM 298 +GT+K+ Sbjct: 559 TSSDDGTVKL 568 Score = 38.9 bits (89), Expect = 0.015 Identities = 50/266 (18%), Positives = 113/266 (42%), Gaps = 44/266 (16%) Query: 190 VLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIWDF 249 +++ ++ ++VW ETG ++ + +G + V + E + +G+ + T+R+WD Sbjct: 354 IISGSTDRTLKVWNAETGECIHTL---YGHTSTVRCMHLHEKRVV--SGSRDATLRVWDI 408 Query: 250 GSGQEMKVLPEGKDWKEDEHCLRRLIFLKAQEKHQQLVLALERNGTIKMIQGKEDDIYLM 309 +GQ CL L+ H V ++ +G +++ G D +++ Sbjct: 409 ETGQ----------------CLHVLM------GHVAAVRCVQYDGR-RVVSGAYD--FMV 443 Query: 310 VIWELPDVVPFLQDGKHAVHLRMSTRDRNMAIPFPDVELIVERNFSQPTDNPTMDLLRVN 369 +W+ + + +H +R ++ F + ++ + S T D+ N Sbjct: 444 KVWD--------PETETCLHTLQGHTNRVYSLQFDGIHVV---SGSLDTSIRVWDVETGN 492 Query: 370 CIDLLQVEGYNLIAAGTLNEGHVILCNISSFLDPPHDEKKFKQLLSWRAHSLEIIQVIYV 429 CI L G+ + +G + ++++ + D K + L + + + V + Sbjct: 493 CIHTLT--GHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCL 550 Query: 430 E-EKQVVLTASIDGSVRLWHALNGHY 454 + K V+T+S DG+V+LW G + Sbjct: 551 QFNKNFVITSSDDGTVKLWDLKTGEF 576 >gi|16445438 bromodomain and WD repeat domain containing 1 isoform B [Homo sapiens] Length = 2269 Score = 55.1 bits (131), Expect = 2e-07 Identities = 58/288 (20%), Positives = 123/288 (42%), Gaps = 32/288 (11%) Query: 51 YCVK----ANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSS 106 YCV + I TG DD ++++W + + + + L GH I+++ N ++ + + S Sbjct: 190 YCVAFDRTGHRIFTGSDDCLVKIWSTH-NGRLLSTLRGHSAEISDMAVNYENTMIAAGSC 248 Query: 107 AKVFRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSS---VMDMYPLTRM 163 K+ RVW ++T + + V G +Q M + M+ TG+ + L + Sbjct: 249 DKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESL 308 Query: 164 IQDTKQVPHTHEREINVMLYNKYFHQ----VLTICSESIIRVWELETGLQV-YQILEPHG 218 + + T + V + F + T ++ +IR++ L G + +I E Sbjct: 309 KFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFL--GFEAPEKIAELES 366 Query: 219 FNTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPE------GKDWKEDEHCLR 272 +V S +G F +G+ +GT RIW F + +L + G E+E ++ Sbjct: 367 HTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEERFMK 426 Query: 273 RLIFLKAQEKHQQLVLALERNGTIKM-----------IQGKEDDIYLM 309 + + A ++ +V+ + +K+ + G D+++++ Sbjct: 427 PKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVL 474 Score = 37.7 bits (86), Expect = 0.033 Identities = 50/236 (21%), Positives = 89/236 (37%), Gaps = 39/236 (16%) Query: 25 LESLKRLEDNLPVREFSMPRGANTFC--YCVKANVIVTGGDDKVIRLWHPNIST-KPVGK 81 LESLK L E P G C + V + TG D VIR++ + + + Sbjct: 305 LESLKFSPRPLKFTEKPRP-GVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAE 363 Query: 82 LVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIY 141 L H + I +S S R+W + L + Sbjct: 364 LESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSI------------------ 405 Query: 142 DANHGMLITGSSVMDMYPLTRMIQD-TKQVPHTHEREINVMLYNKYFHQVLTICSESIIR 200 ++DM TR+ D + + + ++ ++ +N+ V+T ++ +++ Sbjct: 406 ------------LLDM--ATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLK 451 Query: 201 VWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMK 256 VW TG Q+ L H V +S + + G ++G++ IWD G +MK Sbjct: 452 VWNSYTG-QLLHNLMGHADEVFVLETHPFDSRIMLSAG-HDGSIFIWDITKGTKMK 505 Score = 34.3 bits (77), Expect = 0.36 Identities = 20/110 (18%), Positives = 47/110 (42%), Gaps = 5/110 (4%) Query: 140 IYDANHGMLITGSSVMDMYPLTRMIQDTKQVPHT--HEREINVMLYNKYFHQVLTICSES 197 + + + G +TG S M Q K H + + +++ H++ T + Sbjct: 149 LVEIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDC 208 Query: 198 IIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIW 247 ++++W G + + G + E++ AV+ + A G+ + +R+W Sbjct: 209 LVKIWSTHNGRLLSTL---RGHSAEISDMAVNYENTMIAAGSCDKIIRVW 255 >gi|16445436 bromodomain and WD repeat domain containing 1 isoform A [Homo sapiens] Length = 2320 Score = 55.1 bits (131), Expect = 2e-07 Identities = 58/288 (20%), Positives = 123/288 (42%), Gaps = 32/288 (11%) Query: 51 YCVK----ANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSS 106 YCV + I TG DD ++++W + + + + L GH I+++ N ++ + + S Sbjct: 190 YCVAFDRTGHRIFTGSDDCLVKIWSTH-NGRLLSTLRGHSAEISDMAVNYENTMIAAGSC 248 Query: 107 AKVFRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSS---VMDMYPLTRM 163 K+ RVW ++T + + V G +Q M + M+ TG+ + L + Sbjct: 249 DKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESL 308 Query: 164 IQDTKQVPHTHEREINVMLYNKYFHQ----VLTICSESIIRVWELETGLQV-YQILEPHG 218 + + T + V + F + T ++ +IR++ L G + +I E Sbjct: 309 KFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFL--GFEAPEKIAELES 366 Query: 219 FNTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPE------GKDWKEDEHCLR 272 +V S +G F +G+ +GT RIW F + +L + G E+E ++ Sbjct: 367 HTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEERFMK 426 Query: 273 RLIFLKAQEKHQQLVLALERNGTIKM-----------IQGKEDDIYLM 309 + + A ++ +V+ + +K+ + G D+++++ Sbjct: 427 PKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVL 474 Score = 37.7 bits (86), Expect = 0.033 Identities = 50/236 (21%), Positives = 89/236 (37%), Gaps = 39/236 (16%) Query: 25 LESLKRLEDNLPVREFSMPRGANTFC--YCVKANVIVTGGDDKVIRLWHPNIST-KPVGK 81 LESLK L E P G C + V + TG D VIR++ + + + Sbjct: 305 LESLKFSPRPLKFTEKPRP-GVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAE 363 Query: 82 LVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIY 141 L H + I +S S R+W + L + Sbjct: 364 LESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSI------------------ 405 Query: 142 DANHGMLITGSSVMDMYPLTRMIQD-TKQVPHTHEREINVMLYNKYFHQVLTICSESIIR 200 ++DM TR+ D + + + ++ ++ +N+ V+T ++ +++ Sbjct: 406 ------------LLDM--ATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLK 451 Query: 201 VWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMK 256 VW TG Q+ L H V +S + + G ++G++ IWD G +MK Sbjct: 452 VWNSYTG-QLLHNLMGHADEVFVLETHPFDSRIMLSAG-HDGSIFIWDITKGTKMK 505 Score = 34.3 bits (77), Expect = 0.36 Identities = 20/110 (18%), Positives = 47/110 (42%), Gaps = 5/110 (4%) Query: 140 IYDANHGMLITGSSVMDMYPLTRMIQDTKQVPHT--HEREINVMLYNKYFHQVLTICSES 197 + + + G +TG S M Q K H + + +++ H++ T + Sbjct: 149 LVEIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDC 208 Query: 198 IIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIW 247 ++++W G + + G + E++ AV+ + A G+ + +R+W Sbjct: 209 LVKIWSTHNGRLLSTL---RGHSAEISDMAVNYENTMIAAGSCDKIIRVW 255 >gi|48928050 F-box and WD repeat domain containing 11 isoform C [Homo sapiens] Length = 542 Score = 51.6 bits (122), Expect = 2e-06 Identities = 57/277 (20%), Positives = 118/277 (42%), Gaps = 30/277 (10%) Query: 47 NTFCYCVKANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSS 106 + C VIVTG D +R+W N + + + L+ H ++ + + +V+ S Sbjct: 282 SVLCLQYDERVIVTGSSDSTVRVWDVN-TGEVLNTLIHHNEAVLHL--RFSNGLMVTCSK 338 Query: 107 AKVFRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQD 166 + VWD+ + + + + G + + +D + + +G + ++ + + Sbjct: 339 DRSIAVWDMASATDITLRRVLVGHRAAVNVVD--FDDKYIVSASGDRTIKVWSTSTC--E 394 Query: 167 TKQVPHTHEREINVMLYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSA 226 + + H+R I + Y V++ S++ IR+W++E G ++LE H E Sbjct: 395 FVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECG-ACLRVLEGH----EELVR 447 Query: 227 AVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDWKEDEHCLRRLIFLKAQEKHQQL 286 + +GAY+G +++WD + + + CLR L+ +H Sbjct: 448 CIRFDNKRIVSGAYDGKIKVWDLQAALDPRA-------PASTLCLRTLV------EHSGR 494 Query: 287 VLALERNGTIKMIQGKEDDIYLMVIWELPDVVPFLQD 323 V L+ + ++I DD L IW+ +V P Q+ Sbjct: 495 VFRLQFD-EFQIISSSHDDTIL--IWDFLNVPPSAQN 528 Score = 33.1 bits (74), Expect = 0.80 Identities = 18/70 (25%), Positives = 38/70 (54%), Gaps = 5/70 (7%) Query: 189 QVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIWD 248 ++++ ++ I++W+ +T L+ ++L H V DE + TG+ + TVR+WD Sbjct: 252 KIISGLRDNSIKIWD-KTSLECLKVLTGH--TGSVLCLQYDER--VIVTGSSDSTVRVWD 306 Query: 249 FGSGQEMKVL 258 +G+ + L Sbjct: 307 VNTGEVLNTL 316 >gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] Length = 357 Score = 51.6 bits (122), Expect = 2e-06 Identities = 47/208 (22%), Positives = 85/208 (40%), Gaps = 24/208 (11%) Query: 51 YCVK----ANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSS 106 YC K + + + G D++I LW+ L GH ++ E+ N + S S+ Sbjct: 70 YCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSAST 129 Query: 107 AKVFRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHG--MLITGS--SVMDMYPLTR 162 K VWD +T ++ G + Y A G ++ TGS + ++ + + Sbjct: 130 DKTVAVWDSETGERVKRL------KGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRK 183 Query: 163 MIQDTKQVPHTHEREINVM--LYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFN 220 K T + V+ +N Q+++ ++ I+VW+L Y + G Sbjct: 184 -----KAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTM---RGHA 235 Query: 221 TEVTSAAVDESGFLFATGAYNGTVRIWD 248 VT ++ G + A + TVR+WD Sbjct: 236 DSVTGLSLSSEGSYLLSNAMDNTVRVWD 263 Score = 38.9 bits (89), Expect = 0.015 Identities = 37/216 (17%), Positives = 84/216 (38%), Gaps = 15/216 (6%) Query: 51 YCVKANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAK-V 109 Y +++ + DK + +W + V +L GH + + +V S Sbjct: 117 YNTDGSMLFSASTDKTVAVWDSETGER-VKRLKGHTSFVNSCYPARRGPQLVCTGSDDGT 175 Query: 110 FRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTKQ 169 ++WDI+ + +Q F ++ Q+ ++ ++ +I+G D+ Sbjct: 176 VKLWDIRKKAAIQTFQNTY------QVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTY 229 Query: 170 VPHTHEREINVMLYNKYFHQVLTICSESIIRVWEL------ETGLQVYQILEPHGFNTEV 223 H + + + +L+ ++ +RVW++ E ++++Q H F + Sbjct: 230 TMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQG-NVHNFEKNL 288 Query: 224 TSAAVDESGFLFATGAYNGTVRIWDFGSGQEMKVLP 259 + G A G+ + V +WD S + + LP Sbjct: 289 LRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLP 324 Score = 29.6 bits (65), Expect = 8.9 Identities = 18/59 (30%), Positives = 30/59 (50%), Gaps = 1/59 (1%) Query: 58 IVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQ 116 I G D+ + +W S + + KL GH SI E+ + + ++S SS K + +IQ Sbjct: 300 IAAGSADRFVYVWDTT-SRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357 >gi|48928048 F-box and WD repeat domain containing 11 isoform A [Homo sapiens] Length = 508 Score = 51.6 bits (122), Expect = 2e-06 Identities = 57/277 (20%), Positives = 118/277 (42%), Gaps = 30/277 (10%) Query: 47 NTFCYCVKANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSS 106 + C VIVTG D +R+W N + + + L+ H ++ + + +V+ S Sbjct: 248 SVLCLQYDERVIVTGSSDSTVRVWDVN-TGEVLNTLIHHNEAVLHL--RFSNGLMVTCSK 304 Query: 107 AKVFRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQD 166 + VWD+ + + + + G + + +D + + +G + ++ + + Sbjct: 305 DRSIAVWDMASATDITLRRVLVGHRAAVNVVD--FDDKYIVSASGDRTIKVWSTSTC--E 360 Query: 167 TKQVPHTHEREINVMLYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSA 226 + + H+R I + Y V++ S++ IR+W++E G ++LE H E Sbjct: 361 FVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECG-ACLRVLEGH----EELVR 413 Query: 227 AVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDWKEDEHCLRRLIFLKAQEKHQQL 286 + +GAY+G +++WD + + + CLR L+ +H Sbjct: 414 CIRFDNKRIVSGAYDGKIKVWDLQAALDPRA-------PASTLCLRTLV------EHSGR 460 Query: 287 VLALERNGTIKMIQGKEDDIYLMVIWELPDVVPFLQD 323 V L+ + ++I DD L IW+ +V P Q+ Sbjct: 461 VFRLQFD-EFQIISSSHDDTIL--IWDFLNVPPSAQN 494 Score = 33.1 bits (74), Expect = 0.80 Identities = 18/70 (25%), Positives = 38/70 (54%), Gaps = 5/70 (7%) Query: 189 QVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIWD 248 ++++ ++ I++W+ +T L+ ++L H V DE + TG+ + TVR+WD Sbjct: 218 KIISGLRDNSIKIWD-KTSLECLKVLTGH--TGSVLCLQYDER--VIVTGSSDSTVRVWD 272 Query: 249 FGSGQEMKVL 258 +G+ + L Sbjct: 273 VNTGEVLNTL 282 >gi|48928046 F-box and WD repeat domain containing 11 isoform B [Homo sapiens] Length = 529 Score = 51.6 bits (122), Expect = 2e-06 Identities = 57/277 (20%), Positives = 118/277 (42%), Gaps = 30/277 (10%) Query: 47 NTFCYCVKANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSS 106 + C VIVTG D +R+W N + + + L+ H ++ + + +V+ S Sbjct: 269 SVLCLQYDERVIVTGSSDSTVRVWDVN-TGEVLNTLIHHNEAVLHL--RFSNGLMVTCSK 325 Query: 107 AKVFRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQD 166 + VWD+ + + + + G + + +D + + +G + ++ + + Sbjct: 326 DRSIAVWDMASATDITLRRVLVGHRAAVNVVD--FDDKYIVSASGDRTIKVWSTSTC--E 381 Query: 167 TKQVPHTHEREINVMLYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSA 226 + + H+R I + Y V++ S++ IR+W++E G ++LE H E Sbjct: 382 FVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECG-ACLRVLEGH----EELVR 434 Query: 227 AVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDWKEDEHCLRRLIFLKAQEKHQQL 286 + +GAY+G +++WD + + + CLR L+ +H Sbjct: 435 CIRFDNKRIVSGAYDGKIKVWDLQAALDPRA-------PASTLCLRTLV------EHSGR 481 Query: 287 VLALERNGTIKMIQGKEDDIYLMVIWELPDVVPFLQD 323 V L+ + ++I DD L IW+ +V P Q+ Sbjct: 482 VFRLQFD-EFQIISSSHDDTIL--IWDFLNVPPSAQN 515 Score = 33.1 bits (74), Expect = 0.80 Identities = 18/70 (25%), Positives = 38/70 (54%), Gaps = 5/70 (7%) Query: 189 QVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIWD 248 ++++ ++ I++W+ +T L+ ++L H V DE + TG+ + TVR+WD Sbjct: 239 KIISGLRDNSIKIWD-KTSLECLKVLTGH--TGSVLCLQYDER--VIVTGSSDSTVRVWD 293 Query: 249 FGSGQEMKVL 258 +G+ + L Sbjct: 294 VNTGEVLNTL 303 >gi|102470001 PQQ repeat and WD repeat domain containing [Homo sapiens] Length = 472 Score = 50.8 bits (120), Expect = 4e-06 Identities = 45/220 (20%), Positives = 95/220 (43%), Gaps = 32/220 (14%) Query: 47 NTFCYCVKANVIVTGGDDKVIRLWHP-------NISTKPVGKLVGHMFSIAEIVTNEKDQ 99 +T +CV +++G D ++LW P + +P +V E Sbjct: 106 STCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVV-------ECSITGDSS 158 Query: 100 HVVSLSSAKVFRVWDIQTLSLL-QVFHDS-----QGGPGDMQIYSMIYDANHGMLITGSS 153 V++ S K R WD++T LL +V +D+ + P + S +D +HG+ I Sbjct: 159 RVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSG-FDVDHGICI---- 213 Query: 154 VMDMYPLTRMIQDTKQVPHTHEREINVMLYNKYFHQVLTICSESIIRVWELETGLQVYQI 213 MD +T + + H R I ++ +V ++ + I++W++ + + I Sbjct: 214 -MDAENITTV----SVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTI 268 Query: 214 LEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQ 253 + H + +++ SG T +++ ++IW+ +G+ Sbjct: 269 TKAH--SNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGE 306 Score = 31.6 bits (70), Expect = 2.3 Identities = 14/75 (18%), Positives = 40/75 (53%), Gaps = 2/75 (2%) Query: 45 GANTFCYCVK-ANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVS 103 G+ + C+ + ++ +++GG D+ + +W + + L GH + ++ + + ++S Sbjct: 322 GSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLS-LKGHNDWVMDVAISNNKKWILS 380 Query: 104 LSSAKVFRVWDIQTL 118 S + R+W+I+ + Sbjct: 381 ASKDRTMRLWNIEEI 395 >gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [Homo sapiens] Length = 514 Score = 50.1 bits (118), Expect = 6e-06 Identities = 52/249 (20%), Positives = 102/249 (40%), Gaps = 25/249 (10%) Query: 62 GDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSLL 121 G+DK ++ W + K + GH+ ++ + + +V+ S R+WD++T + + Sbjct: 265 GEDKQVKCWDLEYN-KVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASV 323 Query: 122 QVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTKQVPHTHEREINVM 181 ++ A +ITGS + + T+ H++ + + Sbjct: 324 HTLSGHTNAVATVRC-----QAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAV 378 Query: 182 LYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAYN 241 + + H S I+ W+ G + + G N + + V+ G L +GA N Sbjct: 379 VLHPR-HYTFASGSPDNIKQWKFPDGSFIQNL---SGHNAIINTLTVNSDGVL-VSGADN 433 Query: 242 GTVRIWDFGSGQEMK-----VLPEGKDWKEDEHCLRRLIFLKAQEKHQQLVLALERNGTI 296 GT+ +WD+ +G + V P D + IF A ++ + +L E + TI Sbjct: 434 GTMHLWDWRTGYNFQRVHAAVQPGSLDSESG-------IFACAFDQSESRLLTAEADKTI 486 Query: 297 KMIQGKEDD 305 K+ +EDD Sbjct: 487 KVY--REDD 493 >gi|153791630 bromodomain and WD repeat domain containing 3 [Homo sapiens] Length = 1802 Score = 49.7 bits (117), Expect = 8e-06 Identities = 56/290 (19%), Positives = 115/290 (39%), Gaps = 33/290 (11%) Query: 51 YCV----KANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSS 106 YCV I TG DD ++++W + + + L GH I+++ N ++ + + S Sbjct: 184 YCVAFDRSGRRIFTGSDDCLVKIWATD-DGRLLATLRGHSAEISDMAVNYENTLIAAGSC 242 Query: 107 AKVFRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSS----VMDMYPLTR 162 KV RVW ++T + + V +Q N + TG+ + T Sbjct: 243 DKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHVKTM 302 Query: 163 MIQDTKQVPHTHEREINVMLYNKYFHQ----VLTICSESIIRVWELETGL-QVYQILEPH 217 +D + V T V + F + T ++ +IR++ L + + + LE H Sbjct: 303 KFRD-RPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAELESH 361 Query: 218 GFNTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQ------EMKVLPEGKDWKEDEHCL 271 + F +G+ +GT RIW + + +M G + E + Sbjct: 362 TDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKI 421 Query: 272 RRL-IFLKAQEKHQQLVLALERNGTIKM-----------IQGKEDDIYLM 309 +L + + A +++ V+ N +K+ + G +D+++++ Sbjct: 422 TKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVL 471 >gi|21536371 telomerase-associated protein 1 [Homo sapiens] Length = 2627 Score = 49.3 bits (116), Expect = 1e-05 Identities = 46/200 (23%), Positives = 85/200 (42%), Gaps = 45/200 (22%) Query: 48 TFCYCVKANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSA 107 T C K N++++ D + LW P S + +G+ +GH +++ + E +HVVS+S Sbjct: 2111 TGCAWTKDNLLISCSSDGSVGLWDPE-SGQRLGQFLGHQSAVSAVAAVE--EHVVSVSRD 2167 Query: 108 KVFRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDT 167 +VWD Q + L + A+ G + ++ M+ Sbjct: 2168 GTLKVWDHQGVELTSI------------------PAHSGPISHCAAAME----------- 2198 Query: 168 KQVPHTHEREINVMLYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAA 227 P + + +L V+T+ + R+W Q + +L G + V +AA Sbjct: 2199 ---PRAAGQPGSELL-------VVTVGLDGATRLWHPLLVCQTHTLL---GHSGPVRAAA 2245 Query: 228 VDESGFLFATGAYNGTVRIW 247 V E+ L T + +G+VR+W Sbjct: 2246 VSETSGLMLTASEDGSVRLW 2265 Score = 29.6 bits (65), Expect = 8.9 Identities = 16/59 (27%), Positives = 28/59 (47%), Gaps = 1/59 (1%) Query: 57 VIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDI 115 ++VT G D RLWHP + + L+GH + +E +++ S R+W + Sbjct: 2210 LVVTVGLDGATRLWHPLLVCQ-THTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQV 2267 >gi|4502477 beta-transducin repeat containing protein isoform 2 [Homo sapiens] Length = 569 Score = 48.9 bits (115), Expect = 1e-05 Identities = 55/267 (20%), Positives = 116/267 (43%), Gaps = 30/267 (11%) Query: 47 NTFCYCVKANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSS 106 + C VI+TG D +R+W N + + + L+ H ++ + N + +V+ S Sbjct: 309 SVLCLQYDERVIITGSSDSTVRVWDVN-TGEMLNTLIHHCEAVLHLRFN--NGMMVTCSK 365 Query: 107 AKVFRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQD 166 + VWD+ + + + + G + + +D + + +G + ++ + + Sbjct: 366 DRSIAVWDMASPTDITLRRVLVGHRAAVNVVD--FDDKYIVSASGDRTIKVWNTSTC--E 421 Query: 167 TKQVPHTHEREINVMLYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSA 226 + + H+R I + Y V++ S++ IR+W++E G ++LE H E Sbjct: 422 FVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECG-ACLRVLEGH----EELVR 474 Query: 227 AVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDWKEDEHCLRRLIFLKAQEKHQQL 286 + +GAY+G +++WD + + + P G CLR L+ +H Sbjct: 475 CIRFDNKRIVSGAYDGKIKVWDLVAALDPRA-PAG------TLCLRTLV------EHSGR 521 Query: 287 VLALERNGTIKMIQGKEDDIYLMVIWE 313 V L+ + +++ DD L IW+ Sbjct: 522 VFRLQFD-EFQIVSSSHDDTIL--IWD 545 Score = 33.1 bits (74), Expect = 0.80 Identities = 47/238 (19%), Positives = 103/238 (43%), Gaps = 33/238 (13%) Query: 98 DQHVVSLSSAKVFRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSS---- 153 DQ +VS ++WD TL ++ G + + YD ++ITGSS Sbjct: 277 DQKIVSGLRDNTIKIWDKNTLECKRILTGHTG-----SVLCLQYDER--VIITGSSDSTV 329 Query: 154 -VMDMYPLTRMIQDTKQVPHTHEREINVMLYNKYFHQVLTICS-ESIIRVWEL--ETGLQ 209 V D+ +T ++ +T +L+ ++ + ++ CS + I VW++ T + Sbjct: 330 RVWDV--------NTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDIT 381 Query: 210 VYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDWKEDEH 269 + ++L H V D+ + A+G + T+++W+ + + ++ L K Sbjct: 382 LRRVLVGH--RAAVNVVDFDDKYIVSASG--DRTIKVWNTSTCEFVRTL---NGHKRGIA 434 Query: 270 CL--RRLIFLKAQEKHQQLVLALERNGTIKMIQGKEDDIYLMVIWELPDVVPFLQDGK 325 CL R + + + + +E +++++G E ++ + ++ +V DGK Sbjct: 435 CLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHE-ELVRCIRFDNKRIVSGAYDGK 491 >gi|16117783 beta-transducin repeat containing protein isoform 1 [Homo sapiens] Length = 605 Score = 48.9 bits (115), Expect = 1e-05 Identities = 55/267 (20%), Positives = 116/267 (43%), Gaps = 30/267 (11%) Query: 47 NTFCYCVKANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSS 106 + C VI+TG D +R+W N + + + L+ H ++ + N + +V+ S Sbjct: 345 SVLCLQYDERVIITGSSDSTVRVWDVN-TGEMLNTLIHHCEAVLHLRFN--NGMMVTCSK 401 Query: 107 AKVFRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQD 166 + VWD+ + + + + G + + +D + + +G + ++ + + Sbjct: 402 DRSIAVWDMASPTDITLRRVLVGHRAAVNVVD--FDDKYIVSASGDRTIKVWNTSTC--E 457 Query: 167 TKQVPHTHEREINVMLYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSA 226 + + H+R I + Y V++ S++ IR+W++E G ++LE H E Sbjct: 458 FVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECG-ACLRVLEGH----EELVR 510 Query: 227 AVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDWKEDEHCLRRLIFLKAQEKHQQL 286 + +GAY+G +++WD + + + P G CLR L+ +H Sbjct: 511 CIRFDNKRIVSGAYDGKIKVWDLVAALDPRA-PAG------TLCLRTLV------EHSGR 557 Query: 287 VLALERNGTIKMIQGKEDDIYLMVIWE 313 V L+ + +++ DD L IW+ Sbjct: 558 VFRLQFD-EFQIVSSSHDDTIL--IWD 581 Score = 33.1 bits (74), Expect = 0.80 Identities = 47/238 (19%), Positives = 103/238 (43%), Gaps = 33/238 (13%) Query: 98 DQHVVSLSSAKVFRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSS---- 153 DQ +VS ++WD TL ++ G + + YD ++ITGSS Sbjct: 313 DQKIVSGLRDNTIKIWDKNTLECKRILTGHTG-----SVLCLQYDER--VIITGSSDSTV 365 Query: 154 -VMDMYPLTRMIQDTKQVPHTHEREINVMLYNKYFHQVLTICS-ESIIRVWEL--ETGLQ 209 V D+ +T ++ +T +L+ ++ + ++ CS + I VW++ T + Sbjct: 366 RVWDV--------NTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDIT 417 Query: 210 VYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDWKEDEH 269 + ++L H V D+ + A+G + T+++W+ + + ++ L K Sbjct: 418 LRRVLVGH--RAAVNVVDFDDKYIVSASG--DRTIKVWNTSTCEFVRTL---NGHKRGIA 470 Query: 270 CL--RRLIFLKAQEKHQQLVLALERNGTIKMIQGKEDDIYLMVIWELPDVVPFLQDGK 325 CL R + + + + +E +++++G E ++ + ++ +V DGK Sbjct: 471 CLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHE-ELVRCIRFDNKRIVSGAYDGK 527 >gi|83779014 katanin p80 subunit B 1 [Homo sapiens] Length = 655 Score = 48.1 bits (113), Expect = 2e-05 Identities = 38/194 (19%), Positives = 81/194 (41%), Gaps = 13/194 (6%) Query: 57 VIVTGGDDKVIRLWHPNISTKP--VGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWD 114 ++ TGGDD + LW N KP + L GH + + N ++ +V+ S + RVWD Sbjct: 35 LLATGGDDCRVNLWSIN---KPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWD 91 Query: 115 IQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTKQVPHTH 174 ++ +L+ + I S+ + + +GS ++ + H Sbjct: 92 LEAAKILRTLMGHKA-----NICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGH 146 Query: 175 EREINVMLYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFL 234 + + + ++ + + + +++W+L G + + G V + +L Sbjct: 147 SQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEF---PGHTGPVNVVEFHPNEYL 203 Query: 235 FATGAYNGTVRIWD 248 A+G+ + T+R WD Sbjct: 204 LASGSSDRTIRFWD 217 Score = 33.5 bits (75), Expect = 0.61 Identities = 35/157 (22%), Positives = 69/157 (43%), Gaps = 19/157 (12%) Query: 58 IVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQT 117 + + DD ++LW K + + GH + + + + + S SS + R WD++ Sbjct: 162 LASAADDHTVKLWDLTAG-KMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEK 220 Query: 118 LSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTKQV-PHTHER 176 QV +G PG ++ S++++ + L +G QD+ +V ER Sbjct: 221 ---FQVVSCIEGEPGPVR--SVLFNPDGCCLYSG------------CQDSLRVYGWEPER 263 Query: 177 EINVMLYNKYFHQVLTICSESIIRVWELETGLQVYQI 213 +V+L N L IC++ +I V ++ + Y + Sbjct: 264 CFDVVLVNWGKVADLAICNDQLIGVAFSQSNVSSYVV 300 >gi|51242945 striatin, calmodulin binding protein [Homo sapiens] Length = 780 Score = 48.1 bits (113), Expect = 2e-05 Identities = 55/236 (23%), Positives = 109/236 (46%), Gaps = 26/236 (11%) Query: 36 PVREFSMPRGANTFCYCVKAN--VIVTGGDDKVIRLWH---PNI----STKPV---GKLV 83 P+ F +G C + +N +GG D +I+ W+ PNI S P G L+ Sbjct: 508 PIYTFRAHKGP-VLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLL 566 Query: 84 GHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLS-LLQVFHDSQ--GGPGDMQIYSMI 140 GH ++ + + Q ++S S+ R+W+ ++ L VF+D++ G P + + S Sbjct: 567 GHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLVSS- 625 Query: 141 YDANHGMLITG---SSVMDMYPLTRMIQDTKQVPHTHER--EINVMLYNKYFHQVLTICS 195 D +H + +S+ +M R++ V T +IN ++ + +T Sbjct: 626 -DPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHE 684 Query: 196 ESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIWDFGS 251 + I+ ++ TG ++ ++ VTS AVD +G +G+++ ++R+W+ S Sbjct: 685 DRHIKFYDNNTGKLIHSMV---AHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLES 737 >gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapiens] Length = 522 Score = 47.4 bits (111), Expect = 4e-05 Identities = 43/203 (21%), Positives = 87/203 (42%), Gaps = 14/203 (6%) Query: 64 DKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSLLQV 123 D ++LW + S +PV + GH +A ++ + + + + + +R+WD++ ++ Sbjct: 302 DGSVKLWSLD-SDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQE--EI 358 Query: 124 FHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTKQVP--HTHEREINVM 181 H G +Y + + + + TG +D + ++ + + H +EI + Sbjct: 359 LHQEGHSMG---VYDIAFHQDGSLAGTGG--LDAFGRVWDLRTGRCIMFLEGHLKEIYGI 413 Query: 182 LYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAYN 241 ++ + + T ++ +VW+L VY I T V + G TGAY+ Sbjct: 414 NFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPI--HGNFLLTGAYD 471 Query: 242 GTVRIWDFGSGQEMKVLP--EGK 262 T +IW +K L EGK Sbjct: 472 NTAKIWTHPGWSPLKTLAGHEGK 494 Score = 32.0 bits (71), Expect = 1.8 Identities = 16/62 (25%), Positives = 30/62 (48%), Gaps = 3/62 (4%) Query: 53 VKANVIVTGGDDKVIRLW-HPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFR 111 + N ++TG D ++W HP S P+ L GH + + + Q + + S + F+ Sbjct: 460 IHGNFLLTGAYDNTAKIWTHPGWS--PLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFK 517 Query: 112 VW 113 +W Sbjct: 518 LW 519 >gi|23199987 WD repeat domain 5B [Homo sapiens] Length = 330 Score = 47.4 bits (111), Expect = 4e-05 Identities = 37/188 (19%), Positives = 85/188 (45%), Gaps = 10/188 (5%) Query: 71 HPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSLLQVFHDSQGG 130 +PN + K LVGH +++ + + + + S S+ ++ +W + + Sbjct: 28 NPNYALKCT--LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGH--- 82 Query: 131 PGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTKQVPHTHEREINVMLYNKYFHQV 190 +++I + + ++ L++ S + + H + +N + + Sbjct: 83 --NLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLI 140 Query: 191 LTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIWDFG 250 ++ + +++WE++TG + + L H + V++ + SG L +G+Y+G RIWD Sbjct: 141 ISGSFDETVKIWEVKTG-KCLKTLSAH--SDPVSAVHFNCSGSLIVSGSYDGLCRIWDAA 197 Query: 251 SGQEMKVL 258 SGQ +K L Sbjct: 198 SGQCLKTL 205 Score = 38.5 bits (88), Expect = 0.019 Identities = 42/211 (19%), Positives = 92/211 (43%), Gaps = 13/211 (6%) Query: 44 RGANTFCYCVK----ANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQ 99 +G + + +C +N+I++G D+ +++W + K + L H ++ + N Sbjct: 122 KGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVK-TGKCLKTLSAHSDPVSAVHFNCSGS 180 Query: 100 HVVSLSSAKVFRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYP 159 +VS S + R+WD + L+ D P +S + + + T + + ++ Sbjct: 181 LIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSP--NGKYILTATLDNTLKLWD 238 Query: 160 LTRMIQDTKQVPHTHEREINVMLYNKYFHQVLTICSE-SIIRVWELETGLQVYQILEPHG 218 +R H +E+ ++ + + SE +++ +W L+T ++ Q L+ H Sbjct: 239 YSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT-KEIVQKLQGH- 296 Query: 219 FNTEVTSAAVDESGFLFATGAYNG--TVRIW 247 V SAA + L A+ A T+++W Sbjct: 297 -TDVVISAACHPTENLIASAALENDKTIKLW 326 Score = 33.5 bits (75), Expect = 0.61 Identities = 34/208 (16%), Positives = 79/208 (37%), Gaps = 50/208 (24%) Query: 58 IVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQT 117 +V+ DDK ++LW S K + L GH + N ++S S + ++W+++T Sbjct: 98 LVSASDDKTLKLWDVR-SGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKT 156 Query: 118 LSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTKQVPHTHERE 177 L+ + P + ++ ++ + ++++GS Sbjct: 157 GKCLKTL-SAHSDP----VSAVHFNCSGSLIVSGS------------------------- 186 Query: 178 INVMLYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFAT 237 + + R+W+ +G + +++ N V+ +G T Sbjct: 187 -----------------YDGLCRIWDAASGQCLKTLVDDD--NPPVSFVKFSPNGKYILT 227 Query: 238 GAYNGTVRIWDFGSGQEMKVLPEGKDWK 265 + T+++WD+ G+ +K K+ K Sbjct: 228 ATLDNTLKLWDYSRGRCLKTYTGHKNEK 255 Score = 32.3 bits (72), Expect = 1.4 Identities = 17/90 (18%), Positives = 45/90 (50%), Gaps = 3/90 (3%) Query: 174 HEREINVMLYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGF 233 H EI+ + ++ ++++ + +++W++ +G + + G + V + Sbjct: 82 HNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTL---KGHSNYVFCCNFNPPSN 138 Query: 234 LFATGAYNGTVRIWDFGSGQEMKVLPEGKD 263 L +G+++ TV+IW+ +G+ +K L D Sbjct: 139 LIISGSFDETVKIWEVKTGKCLKTLSAHSD 168 >gi|62234438 Notchless gene homolog isoform b [Homo sapiens] Length = 193 Score = 47.4 bits (111), Expect = 4e-05 Identities = 32/145 (22%), Positives = 63/145 (43%), Gaps = 5/145 (3%) Query: 58 IVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQT 117 +V+G DD + LW P KP+ ++ GH I +++ + + V S S K ++WD +T Sbjct: 52 LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRT 111 Query: 118 LSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTKQVPHTHERE 177 L +Y + + A+ +L++GSS + Q H E Sbjct: 112 GKYLASLRGHVAA-----VYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADE 166 Query: 178 INVMLYNKYFHQVLTICSESIIRVW 202 + + ++ +V + + +R+W Sbjct: 167 VYAVDWSPDGQRVASGGKDKCLRIW 191 Score = 35.8 bits (81), Expect = 0.12 Identities = 19/55 (34%), Positives = 29/55 (52%), Gaps = 2/55 (3%) Query: 400 FLDPPHDEKKFKQLLSWRAHSLEIIQVIYVEEKQVVLTASIDGSVRLWHALNGHY 454 FL P ++KK L H I QV++ + ++V +AS D S++LW G Y Sbjct: 62 FLWSPAEDKK--PLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKY 114 Score = 32.7 bits (73), Expect = 1.0 Identities = 28/116 (24%), Positives = 47/116 (40%), Gaps = 11/116 (9%) Query: 148 LITGSSVMDMYPLTRMIQDTKQVPHTHEREINVMLYNKYFHQVLTICSESIIRVWELETG 207 L S D PLTRM H+ IN +L++ V + + I++W+ TG Sbjct: 61 LFLWSPAEDKKPLTRMTG--------HQALINQVLFSPDSRIVASASFDKSIKLWDGRTG 112 Query: 208 LQVYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKD 263 + + G V A L +G+ + T+++WD + + LP D Sbjct: 113 KYLASL---RGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHAD 165 >gi|62234461 Notchless gene homolog isoform a [Homo sapiens] Length = 485 Score = 47.4 bits (111), Expect = 4e-05 Identities = 32/145 (22%), Positives = 63/145 (43%), Gaps = 5/145 (3%) Query: 58 IVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQT 117 +V+G DD + LW P KP+ ++ GH I +++ + + V S S K ++WD +T Sbjct: 344 LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRT 403 Query: 118 LSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTKQVPHTHERE 177 L +Y + + A+ +L++GSS + Q H E Sbjct: 404 GKYLASLRGHVAA-----VYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADE 458 Query: 178 INVMLYNKYFHQVLTICSESIIRVW 202 + + ++ +V + + +R+W Sbjct: 459 VYAVDWSPDGQRVASGGKDKCLRIW 483 Score = 41.6 bits (96), Expect = 0.002 Identities = 66/271 (24%), Positives = 107/271 (39%), Gaps = 49/271 (18%) Query: 194 CSESIIRVWELETGLQVYQILEPH-----GFNTEVTSAAVDESGFLFATGAYNGTVRIWD 248 C I +W+ TG QV + L H G + E A E ++ A+ + +G+VRIWD Sbjct: 175 CKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHAN-PECRYV-ASSSKDGSVRIWD 232 Query: 249 FGSGQEMKVLPEGKDWKEDEHCLRRLIFLKAQEKHQQLVLALERNGTIKMIQGKEDDIYL 308 +G+ ++L H Q V L G + +D Sbjct: 233 TTAGRCERILTG----------------------HTQSVTCLRWGGDGLLYSASQDRT-- 268 Query: 309 MVIWELPDVV--PFLQDGKHAVH-LRMSTRDRNMAIPFPDVELIVERNFSQPTDNPTMD- 364 + +W D V LQ H V+ + +ST F E V Q + + Sbjct: 269 IKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKER 328 Query: 365 -LLRVNCIDLLQVEGYNLIAAGTLNEGHVILCNISSFLDPPHDEKKFKQLLSWRAHSLEI 423 L R N L++ +G + +G+ + + FL P ++KK L H I Sbjct: 329 ALSRYN---LVRGQGPERLVSGS--------DDFTLFLWSPAEDKK--PLTRMTGHQALI 375 Query: 424 IQVIYVEEKQVVLTASIDGSVRLWHALNGHY 454 QV++ + ++V +AS D S++LW G Y Sbjct: 376 NQVLFSPDSRIVASASFDKSIKLWDGRTGKY 406 Score = 32.7 bits (73), Expect = 1.0 Identities = 28/116 (24%), Positives = 47/116 (40%), Gaps = 11/116 (9%) Query: 148 LITGSSVMDMYPLTRMIQDTKQVPHTHEREINVMLYNKYFHQVLTICSESIIRVWELETG 207 L S D PLTRM H+ IN +L++ V + + I++W+ TG Sbjct: 353 LFLWSPAEDKKPLTRMTG--------HQALINQVLFSPDSRIVASASFDKSIKLWDGRTG 404 Query: 208 LQVYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKD 263 + + G V A L +G+ + T+++WD + + LP D Sbjct: 405 KYLASL---RGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHAD 457 >gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] Length = 369 Score = 47.0 bits (110), Expect = 5e-05 Identities = 39/199 (19%), Positives = 83/199 (41%), Gaps = 13/199 (6%) Query: 51 YCVKANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVF 110 +C VT DDK +++W + K + L H+ + + + +VS S K Sbjct: 73 FCSDGQSFVTASDDKTVKVWATH-RQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTV 131 Query: 111 RVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTKQV 170 ++WD + + + + G + D + ++ MD ++ + + Sbjct: 132 KLWDKSSRECVHSYCEHGG-------FVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLL 184 Query: 171 PH--THEREINVMLYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAV 228 H H +N + ++ + ++T S+S +++ +L G +Y + HG T+ A Sbjct: 185 QHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTL---HGHQGPATTVAF 241 Query: 229 DESGFLFATGAYNGTVRIW 247 +G FA+G + V +W Sbjct: 242 SRTGEYFASGGSDEQVMVW 260 Score = 32.0 bits (71), Expect = 1.8 Identities = 17/52 (32%), Positives = 26/52 (50%), Gaps = 3/52 (5%) Query: 196 ESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIW 247 +S + VW ++ + Y+ G VT SG L A+G+ + TVRIW Sbjct: 2 DSCLMVWHMKPQSRAYRFT---GHKDAVTCVNFSPSGHLLASGSRDKTVRIW 50 >gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] Length = 359 Score = 47.0 bits (110), Expect = 5e-05 Identities = 39/199 (19%), Positives = 83/199 (41%), Gaps = 13/199 (6%) Query: 51 YCVKANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVF 110 +C VT DDK +++W + K + L H+ + + + +VS S K Sbjct: 111 FCSDGQSFVTASDDKTVKVWATH-RQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTV 169 Query: 111 RVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTKQV 170 ++WD + + + + G + D + ++ MD ++ + + Sbjct: 170 KLWDKSSRECVHSYCEHGG-------FVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLL 222 Query: 171 PH--THEREINVMLYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAV 228 H H +N + ++ + ++T S+S +++ +L G +Y + HG T+ A Sbjct: 223 QHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTL---HGHQGPATTVAF 279 Query: 229 DESGFLFATGAYNGTVRIW 247 +G FA+G + V +W Sbjct: 280 SRTGEYFASGGSDEQVMVW 298 Score = 32.0 bits (71), Expect = 1.8 Identities = 17/52 (32%), Positives = 26/52 (50%), Gaps = 3/52 (5%) Query: 196 ESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIW 247 +S + VW ++ + Y+ G VT SG L A+G+ + TVRIW Sbjct: 40 DSCLMVWHMKPQSRAYRFT---GHKDAVTCVNFSPSGHLLASGSRDKTVRIW 88 >gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] Length = 407 Score = 47.0 bits (110), Expect = 5e-05 Identities = 39/199 (19%), Positives = 83/199 (41%), Gaps = 13/199 (6%) Query: 51 YCVKANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVF 110 +C VT DDK +++W + K + L H+ + + + +VS S K Sbjct: 111 FCSDGQSFVTASDDKTVKVWATH-RQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTV 169 Query: 111 RVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTKQV 170 ++WD + + + + G + D + ++ MD ++ + + Sbjct: 170 KLWDKSSRECVHSYCEHGG-------FVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLL 222 Query: 171 PH--THEREINVMLYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAV 228 H H +N + ++ + ++T S+S +++ +L G +Y + HG T+ A Sbjct: 223 QHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTL---HGHQGPATTVAF 279 Query: 229 DESGFLFATGAYNGTVRIW 247 +G FA+G + V +W Sbjct: 280 SRTGEYFASGGSDEQVMVW 298 Score = 32.0 bits (71), Expect = 1.8 Identities = 17/52 (32%), Positives = 26/52 (50%), Gaps = 3/52 (5%) Query: 196 ESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIW 247 +S + VW ++ + Y+ G VT SG L A+G+ + TVRIW Sbjct: 40 DSCLMVWHMKPQSRAYRFT---GHKDAVTCVNFSPSGHLLASGSRDKTVRIW 88 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.321 0.137 0.413 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 24,299,620 Number of Sequences: 37866 Number of extensions: 1065339 Number of successful extensions: 3488 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 57 Number of HSP's successfully gapped in prelim test: 109 Number of HSP's that attempted gapping in prelim test: 2604 Number of HSP's gapped (non-prelim): 799 length of query: 634 length of database: 18,247,518 effective HSP length: 108 effective length of query: 526 effective length of database: 14,157,990 effective search space: 7447102740 effective search space used: 7447102740 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.