Guide to the Human Genome
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Search of human proteins with 115495443

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|115495443 WD repeat domain 64 [Homo sapiens]
         (634 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|115495443 WD repeat domain 64 [Homo sapiens]                      1284   0.0  
gi|221139921 EF-hand calcium binding domain 8 [Homo sapiens]          119   7e-27
gi|30520335 WD repeat domain 49 [Homo sapiens]                        108   1e-23
gi|32189425 WD repeat domain 69 [Homo sapiens]                         60   5e-09
gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Hom...    59   1e-08
gi|34996489 pleckstrin homology domain interacting protein [Homo...    59   1e-08
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H...    57   7e-08
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H...    57   7e-08
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H...    57   7e-08
gi|16445438 bromodomain and WD repeat domain containing 1 isofor...    55   2e-07
gi|16445436 bromodomain and WD repeat domain containing 1 isofor...    55   2e-07
gi|48928050 F-box and WD repeat domain containing 11 isoform C [...    52   2e-06
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]    52   2e-06
gi|48928048 F-box and WD repeat domain containing 11 isoform A [...    52   2e-06
gi|48928046 F-box and WD repeat domain containing 11 isoform B [...    52   2e-06
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa...    51   4e-06
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [...    50   6e-06
gi|153791630 bromodomain and WD repeat domain containing 3 [Homo...    50   8e-06
gi|21536371 telomerase-associated protein 1 [Homo sapiens]             49   1e-05
gi|4502477 beta-transducin repeat containing protein isoform 2 [...    49   1e-05
gi|16117783 beta-transducin repeat containing protein isoform 1 ...    49   1e-05
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                     48   2e-05
gi|51242945 striatin, calmodulin binding protein [Homo sapiens]        48   2e-05
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi...    47   4e-05
gi|23199987 WD repeat domain 5B [Homo sapiens]                         47   4e-05
gi|62234438 Notchless gene homolog isoform b [Homo sapiens]            47   4e-05
gi|62234461 Notchless gene homolog isoform a [Homo sapiens]            47   4e-05
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]             47   5e-05
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]             47   5e-05
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]             47   5e-05

>gi|115495443 WD repeat domain 64 [Homo sapiens]
          Length = 634

 Score = 1284 bits (3323), Expect = 0.0
 Identities = 634/634 (100%), Positives = 634/634 (100%)

Query: 1   MKIRYISALNCFGSCSLDSNHSLVLESLKRLEDNLPVREFSMPRGANTFCYCVKANVIVT 60
           MKIRYISALNCFGSCSLDSNHSLVLESLKRLEDNLPVREFSMPRGANTFCYCVKANVIVT
Sbjct: 1   MKIRYISALNCFGSCSLDSNHSLVLESLKRLEDNLPVREFSMPRGANTFCYCVKANVIVT 60

Query: 61  GGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSL 120
           GGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSL
Sbjct: 61  GGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSL 120

Query: 121 LQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTKQVPHTHEREINV 180
           LQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTKQVPHTHEREINV
Sbjct: 121 LQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTKQVPHTHEREINV 180

Query: 181 MLYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAY 240
           MLYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAY
Sbjct: 181 MLYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAY 240

Query: 241 NGTVRIWDFGSGQEMKVLPEGKDWKEDEHCLRRLIFLKAQEKHQQLVLALERNGTIKMIQ 300
           NGTVRIWDFGSGQEMKVLPEGKDWKEDEHCLRRLIFLKAQEKHQQLVLALERNGTIKMIQ
Sbjct: 241 NGTVRIWDFGSGQEMKVLPEGKDWKEDEHCLRRLIFLKAQEKHQQLVLALERNGTIKMIQ 300

Query: 301 GKEDDIYLMVIWELPDVVPFLQDGKHAVHLRMSTRDRNMAIPFPDVELIVERNFSQPTDN 360
           GKEDDIYLMVIWELPDVVPFLQDGKHAVHLRMSTRDRNMAIPFPDVELIVERNFSQPTDN
Sbjct: 301 GKEDDIYLMVIWELPDVVPFLQDGKHAVHLRMSTRDRNMAIPFPDVELIVERNFSQPTDN 360

Query: 361 PTMDLLRVNCIDLLQVEGYNLIAAGTLNEGHVILCNISSFLDPPHDEKKFKQLLSWRAHS 420
           PTMDLLRVNCIDLLQVEGYNLIAAGTLNEGHVILCNISSFLDPPHDEKKFKQLLSWRAHS
Sbjct: 361 PTMDLLRVNCIDLLQVEGYNLIAAGTLNEGHVILCNISSFLDPPHDEKKFKQLLSWRAHS 420

Query: 421 LEIIQVIYVEEKQVVLTASIDGSVRLWHALNGHYCGYFGQRRLFELSQTRDFILPCDVTE 480
           LEIIQVIYVEEKQVVLTASIDGSVRLWHALNGHYCGYFGQRRLFELSQTRDFILPCDVTE
Sbjct: 421 LEIIQVIYVEEKQVVLTASIDGSVRLWHALNGHYCGYFGQRRLFELSQTRDFILPCDVTE 480

Query: 481 YPIEIKEESKFTEKQKYEYPLIFDREKWRKMSSVSLLFKRTPPKAFEVEQDFKFFKSLSS 540
           YPIEIKEESKFTEKQKYEYPLIFDREKWRKMSSVSLLFKRTPPKAFEVEQDFKFFKSLSS
Sbjct: 481 YPIEIKEESKFTEKQKYEYPLIFDREKWRKMSSVSLLFKRTPPKAFEVEQDFKFFKSLSS 540

Query: 541 PKIRRYPLEGFVTENREAGIVFGSLPIYSISSPTSLRFLPLIGVEAQKDSSDGITGKKKG 600
           PKIRRYPLEGFVTENREAGIVFGSLPIYSISSPTSLRFLPLIGVEAQKDSSDGITGKKKG
Sbjct: 541 PKIRRYPLEGFVTENREAGIVFGSLPIYSISSPTSLRFLPLIGVEAQKDSSDGITGKKKG 600

Query: 601 GHVQREKAPRRRSLKKNLVPQINLASSFFPAIPK 634
           GHVQREKAPRRRSLKKNLVPQINLASSFFPAIPK
Sbjct: 601 GHVQREKAPRRRSLKKNLVPQINLASSFFPAIPK 634


>gi|221139921 EF-hand calcium binding domain 8 [Homo sapiens]
          Length = 1288

 Score =  119 bits (299), Expect = 7e-27
 Identities = 79/264 (29%), Positives = 131/264 (49%), Gaps = 8/264 (3%)

Query: 2   KIRYISALNCFGSCSLDSNHSLVLESLKRLEDNLP-VREFSMPRGANTFCYCVKANVIVT 60
           ++++I  +N   SCS     SLVL  L       P +    + +G   F YC   N +VT
Sbjct: 328 QVKFIPQMNVVVSCSAIEKSSLVLTILPAKASKKPRLSVLRLRKGILCFDYCPDRNFLVT 387

Query: 61  GGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHV-VSLSSAKVFRVWDIQTLS 119
           GG D  IRLW+P +S +PV  + GH  S+  I+ + ++  + +S+S  K  RVWD+    
Sbjct: 388 GGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILVDSRNNSILISVSKDKNIRVWDMLDYI 447

Query: 120 LLQVFHDSQGGPGDMQIYSMIYDANHGMLITGS---SVMDMYPLTR-MIQDTKQVPHTHE 175
            LQ F       G+  I S  +      LI  +    ++  Y   + +I+  K+   TH 
Sbjct: 448 CLQSFCGKFFALGNCPITSAYFFEKDNTLICSTYSIGILKGYLEAQGLIKARKRT--THC 505

Query: 176 REINVMLYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLF 235
             +  +LY+K F QV++ C    + VWE+ TG +  +     G + E+T+ A+DES    
Sbjct: 506 SPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGRKTMEFAVSGGQHVEMTAMALDESERCL 565

Query: 236 ATGAYNGTVRIWDFGSGQEMKVLP 259
            TG  +GT+++W++  G+ +   P
Sbjct: 566 LTGLRDGTMKMWNYNIGKCLLTFP 589



 Score = 37.0 bits (84), Expect = 0.056
 Identities = 16/47 (34%), Positives = 28/47 (59%), Gaps = 1/47 (2%)

Query: 413 LLSWRAHSLEIIQVIYVEEKQVVLTASIDGSVRLWHALNGHYCGYFG 459
           L++W+ H   +  ++YV+  Q+V++A  D  V+ W  L+G   G FG
Sbjct: 945 LMTWKGHLNSVADILYVDNFQLVISAGQDRDVKAW-KLSGDAIGTFG 990


>gi|30520335 WD repeat domain 49 [Homo sapiens]
          Length = 697

 Score =  108 bits (271), Expect = 1e-23
 Identities = 73/250 (29%), Positives = 126/250 (50%), Gaps = 8/250 (3%)

Query: 29  KRLEDNLPVREFSMPRGANTFCYCVKANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFS 88
           ++ +  L +  F++ +G + F Y  + N+I T G +  + LW+P + +KPVG L GH  S
Sbjct: 5   EKSKKRLNMTSFNIAQGIHAFDYHSRLNLIATAGINNKVCLWNPYVVSKPVGVLWGHSAS 64

Query: 89  IAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGML 148
           +  +    + + + S S  KV R+WDIQ    +Q    S     D +     +D  HG L
Sbjct: 65  VIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRIACSFPKSQDFRCL-FHFDEAHGRL 123

Query: 149 ITGSSVMDMYPLTRMIQDTKQVPHTHEREINVMLYNKYFHQVLTICSESIIRVWELETGL 208
               S  +   L  M  +  +   +HE+ +  +LYN    QV++  + S +  W ++TG 
Sbjct: 124 FI--SFNNQLALLAMKSEASKRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQ 181

Query: 209 QVYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDWKEDE 268
           ++ Q    HG N E+++ A+D +     TG+ +GTV+IWDF +G     L  G+D   D 
Sbjct: 182 KIKQFTGCHG-NAEISTMALDANETRLLTGSTDGTVKIWDF-NGYCHHTLNVGQDGAVD- 238

Query: 269 HCLRRLIFLK 278
             + +++ LK
Sbjct: 239 --ISQILILK 246


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 48/190 (25%), Positives = 82/190 (43%), Gaps = 9/190 (4%)

Query: 58  IVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQT 117
           I+TG  D  + +W  +   K V  L+GH   I+    N     +++ S  K  ++WD   
Sbjct: 234 IITGSFDHTVVVWDADTGRK-VNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATN 292

Query: 118 LSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTKQVPHTHERE 177
              +           D +I    +D    ++ T S+       +   +        HE E
Sbjct: 293 GKCVATLTGH-----DDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGE 347

Query: 178 INVMLYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFAT 237
           I+ + +N   + +LT  S+   R+W+ +TG Q  Q+LE H    E+ S A +  G +  T
Sbjct: 348 ISKISFNPQGNHLLTGSSDKTARIWDAQTG-QCLQVLEGH--TDEIFSCAFNYKGNIVIT 404

Query: 238 GAYNGTVRIW 247
           G+ + T RIW
Sbjct: 405 GSKDNTCRIW 414



 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 38/180 (21%), Positives = 82/180 (45%), Gaps = 13/180 (7%)

Query: 82  LVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIY 141
           L  H+  +  +  N+     ++ S  +  ++WD  +   L      +       +Y++ +
Sbjct: 88  LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRN-----VVYAIAF 142

Query: 142 DANHGMLITGSSVMDMYPLTRMIQDTKQVPHT---HEREINVMLYNKYFHQVLTICSESI 198
           +  +G  I   S      L  +  +T +  HT   H  EI  + +N     V T   ++ 
Sbjct: 143 NNPYGDKIATGSFDKTCKLWSV--ETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTT 200

Query: 199 IRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMKVL 258
            ++W+++ G +VY +    G + E+ S + + SG    TG+++ TV +WD  +G+++ +L
Sbjct: 201 AKLWDIQNGEEVYTL---RGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNIL 257



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 33/103 (32%), Positives = 52/103 (50%), Gaps = 6/103 (5%)

Query: 50  CYCVKANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKV 109
           C+     +I T   D   R++    + K + KL GH   I++I  N +  H+++ SS K 
Sbjct: 310 CFDYTGKLIATASADGTARIFSA-ATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKT 368

Query: 110 FRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGS 152
            R+WD QT   LQV      G  D +I+S  ++    ++ITGS
Sbjct: 369 ARIWDAQTGQCLQVLE----GHTD-EIFSCAFNYKGNIVITGS 406



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 64/303 (21%), Positives = 104/303 (34%), Gaps = 70/303 (23%)

Query: 8   ALNCFGSCSLDSNHSLVLESLKRLEDNLPVREFSMPRGANTFCYCVKAN-----VIVTGG 62
           ALN  GSC +  ++        +L D     E +   G     Y +  N      I TG 
Sbjct: 99  ALNKSGSCFITGSYDRTC----KLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGS 154

Query: 63  DDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSLLQ 122
            DK  +LW      K      GH   I  +  N +   V + S     ++WDIQ    + 
Sbjct: 155 FDKTCKLWSVETG-KCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVY 213

Query: 123 VFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTK-----QVPHTHERE 177
                       +I S+ ++ +   +ITGS     +  T ++ D        +   H  E
Sbjct: 214 TLRGHSA-----EIISLSFNTSGDRIITGS-----FDHTVVVWDADTGRKVNILIGHCAE 263

Query: 178 INVMLYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFAT 237
           I+   +N     +LT   +   ++W+   G  V  +    G + E+  +  D +G L AT
Sbjct: 264 ISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLT---GHDDEILDSCFDYTGKLIAT 320

Query: 238 GAYNGTVRI------------------------------------------WDFGSGQEM 255
            + +GT RI                                          WD  +GQ +
Sbjct: 321 ASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCL 380

Query: 256 KVL 258
           +VL
Sbjct: 381 QVL 383



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 51/245 (20%), Positives = 93/245 (37%), Gaps = 37/245 (15%)

Query: 210 VYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDWKEDEH 269
           ++++L+ H     +T+ A+++SG  F TG+Y+ T ++WD  SG+E+  L           
Sbjct: 84  LFKVLKAHIL--PLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTL----------- 130

Query: 270 CLRRLIFLKAQEKHQQLVLALERNGTI--KMIQGKEDDIYLMVIWELPDVVPFLQDGKHA 327
                      E H+ +V A+  N     K+  G  D      +W        ++ GK  
Sbjct: 131 -----------EGHRNVVYAIAFNNPYGDKIATGSFDK--TCKLWS-------VETGK-C 169

Query: 328 VHLRMSTRDRNMAIPFPDVELIVERNFSQPTDNPTMDLLRVNCIDLLQVEGYNLIAAGTL 387
            H         + + F     +V    S  T     D+     +  L+     +I+    
Sbjct: 170 YHTFRGHTAEIVCLSFNPQSTLVATG-SMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFN 228

Query: 388 NEGHVILCNISSFLDPPHDEKKFKQLLSWRAHSLEIIQVIYVEEKQVVLTASIDGSVRLW 447
             G  I+           D    +++     H  EI    +  +  ++LT S+D + +LW
Sbjct: 229 TSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLW 288

Query: 448 HALNG 452
            A NG
Sbjct: 289 DATNG 293


>gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Homo
           sapiens]
          Length = 504

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 65/295 (22%), Positives = 118/295 (40%), Gaps = 41/295 (13%)

Query: 56  NVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDI 115
           N I+TGG DK + ++  + S + +  L GH   +  +V +     V S S     R+W +
Sbjct: 235 NKILTGGADKNVVVFDKS-SEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSV 293

Query: 116 QTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTKQVPHTHE 175
              S +QV    +     + ++     A    L++ S   D Y     IQ  + +    +
Sbjct: 294 PNASCVQVVRAHESAVTGLSLH-----ATGDYLLSSSD--DQYWAFSDIQTGRVLTKVTD 346

Query: 176 REINVMLYNKYFHQVLTICS----ESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDES 231
                 L    FH    I      +S I++W+L+    V       G +  +TS A  E+
Sbjct: 347 ETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANF---PGHSGPITSIAFSEN 403

Query: 232 GFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDWKEDEHCLRRLIFLKAQEKHQQLVLALE 291
           G+  AT A + +V++WD    +  K L    +++     ++ LIF              +
Sbjct: 404 GYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFE-----VKSLIF--------------D 444

Query: 292 RNGTIKMIQGKEDDIYLMVIW-------ELPDVVPFLQDGKHAVHLRMSTRDRNM 339
           ++GT   + G +  IY+   W       E   +   +  G HA  +  +  DR++
Sbjct: 445 QSGTYLALGGTDVQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSL 499


>gi|34996489 pleckstrin homology domain interacting protein [Homo
           sapiens]
          Length = 1821

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 60/288 (20%), Positives = 121/288 (42%), Gaps = 31/288 (10%)

Query: 51  YCVK----ANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSS 106
           YCV        I TG DD ++++W  +   + +  L GH   I+++  N ++  + + S 
Sbjct: 187 YCVTFDRTGRRIFTGSDDCLVKIWATD-DGRLLATLRGHAAEISDMAVNYENTMIAAGSC 245

Query: 107 AKVFRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSS---VMDMYPLTRM 163
            K+ RVW ++T + L V          +Q   +   +   +  TG+       ++    +
Sbjct: 246 DKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFWLWDAGTL 305

Query: 164 IQDTKQVPHTHEREINVMLYNKYFHQ----VLTICSESIIRVWELETGLQVYQILEPHGF 219
             + +    T      V +    F      + T  ++ IIRV+   +G Q  +I E    
Sbjct: 306 KINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSG-QPEKISELEFH 364

Query: 220 NTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQ------EMKVLPEGKDWKEDEHCLRR 273
             +V S     +   F +G+ +GT RIW F   +      +M   P G++ +  E  + +
Sbjct: 365 TDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSILLDMATRPAGQNLQGIEDKITK 424

Query: 274 L-IFLKAQEKHQQLVLALERNGTIK-----------MIQGKEDDIYLM 309
           + + + A ++H   V+    N T+K           ++ G ED+++++
Sbjct: 425 MKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVL 472


>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
           sapiens]
          Length = 589

 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 56/250 (22%), Positives = 112/250 (44%), Gaps = 34/250 (13%)

Query: 53  VKANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRV 112
           ++ N+I++G  D+ +++W+     + +  L GH  ++  +  +EK   VVS S     RV
Sbjct: 311 MRDNIIISGSTDRTLKVWNAETG-ECIHTLYGHTSTVRCMHLHEK--RVVSGSRDATLRV 367

Query: 113 WDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQD--TKQV 170
           WDI+T   L V          +Q     YD     +++G+     Y     + D  T+  
Sbjct: 368 WDIETGQCLHVLMGHVAAVRCVQ-----YDGRR--VVSGA-----YDFMVKVWDPETETC 415

Query: 171 PHTHEREINVMLYNKYFHQVLTICS--ESIIRVWELETGLQVYQILEPHGFNTEVTSAAV 228
            HT +   N  +Y+  F  +  +    ++ IRVW++ETG  ++ +        +  ++ +
Sbjct: 416 LHTLQGHTN-RVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLT-----GHQSLTSGM 469

Query: 229 DESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDWKEDEHCLRRLIFLKAQEKHQQLVL 288
           +    +  +G  + TV+IWD  +GQ ++ L      +    CL         + ++  V+
Sbjct: 470 ELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCL---------QFNKNFVI 520

Query: 289 ALERNGTIKM 298
               +GT+K+
Sbjct: 521 TSSDDGTVKL 530



 Score = 38.9 bits (89), Expect = 0.015
 Identities = 50/266 (18%), Positives = 113/266 (42%), Gaps = 44/266 (16%)

Query: 190 VLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIWDF 249
           +++  ++  ++VW  ETG  ++ +   +G  + V    + E   +  +G+ + T+R+WD 
Sbjct: 316 IISGSTDRTLKVWNAETGECIHTL---YGHTSTVRCMHLHEKRVV--SGSRDATLRVWDI 370

Query: 250 GSGQEMKVLPEGKDWKEDEHCLRRLIFLKAQEKHQQLVLALERNGTIKMIQGKEDDIYLM 309
            +GQ                CL  L+       H   V  ++ +G  +++ G  D  +++
Sbjct: 371 ETGQ----------------CLHVLM------GHVAAVRCVQYDGR-RVVSGAYD--FMV 405

Query: 310 VIWELPDVVPFLQDGKHAVHLRMSTRDRNMAIPFPDVELIVERNFSQPTDNPTMDLLRVN 369
            +W+         + +  +H      +R  ++ F  + ++   + S  T     D+   N
Sbjct: 406 KVWD--------PETETCLHTLQGHTNRVYSLQFDGIHVV---SGSLDTSIRVWDVETGN 454

Query: 370 CIDLLQVEGYNLIAAGTLNEGHVILCNISSFLDPPHDEKKFKQLLSWRAHSLEIIQVIYV 429
           CI  L   G+  + +G   + ++++   +       D K  + L + +  +     V  +
Sbjct: 455 CIHTLT--GHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCL 512

Query: 430 E-EKQVVLTASIDGSVRLWHALNGHY 454
           +  K  V+T+S DG+V+LW    G +
Sbjct: 513 QFNKNFVITSSDDGTVKLWDLKTGEF 538


>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
           sapiens]
          Length = 707

 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 56/250 (22%), Positives = 112/250 (44%), Gaps = 34/250 (13%)

Query: 53  VKANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRV 112
           ++ N+I++G  D+ +++W+     + +  L GH  ++  +  +EK   VVS S     RV
Sbjct: 429 MRDNIIISGSTDRTLKVWNAETG-ECIHTLYGHTSTVRCMHLHEK--RVVSGSRDATLRV 485

Query: 113 WDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQD--TKQV 170
           WDI+T   L V          +Q     YD     +++G+     Y     + D  T+  
Sbjct: 486 WDIETGQCLHVLMGHVAAVRCVQ-----YDGRR--VVSGA-----YDFMVKVWDPETETC 533

Query: 171 PHTHEREINVMLYNKYFHQVLTICS--ESIIRVWELETGLQVYQILEPHGFNTEVTSAAV 228
            HT +   N  +Y+  F  +  +    ++ IRVW++ETG  ++ +        +  ++ +
Sbjct: 534 LHTLQGHTN-RVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLT-----GHQSLTSGM 587

Query: 229 DESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDWKEDEHCLRRLIFLKAQEKHQQLVL 288
           +    +  +G  + TV+IWD  +GQ ++ L      +    CL         + ++  V+
Sbjct: 588 ELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCL---------QFNKNFVI 638

Query: 289 ALERNGTIKM 298
               +GT+K+
Sbjct: 639 TSSDDGTVKL 648



 Score = 38.9 bits (89), Expect = 0.015
 Identities = 50/266 (18%), Positives = 113/266 (42%), Gaps = 44/266 (16%)

Query: 190 VLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIWDF 249
           +++  ++  ++VW  ETG  ++ +   +G  + V    + E   +  +G+ + T+R+WD 
Sbjct: 434 IISGSTDRTLKVWNAETGECIHTL---YGHTSTVRCMHLHEKRVV--SGSRDATLRVWDI 488

Query: 250 GSGQEMKVLPEGKDWKEDEHCLRRLIFLKAQEKHQQLVLALERNGTIKMIQGKEDDIYLM 309
            +GQ                CL  L+       H   V  ++ +G  +++ G  D  +++
Sbjct: 489 ETGQ----------------CLHVLM------GHVAAVRCVQYDGR-RVVSGAYD--FMV 523

Query: 310 VIWELPDVVPFLQDGKHAVHLRMSTRDRNMAIPFPDVELIVERNFSQPTDNPTMDLLRVN 369
            +W+         + +  +H      +R  ++ F  + ++   + S  T     D+   N
Sbjct: 524 KVWD--------PETETCLHTLQGHTNRVYSLQFDGIHVV---SGSLDTSIRVWDVETGN 572

Query: 370 CIDLLQVEGYNLIAAGTLNEGHVILCNISSFLDPPHDEKKFKQLLSWRAHSLEIIQVIYV 429
           CI  L   G+  + +G   + ++++   +       D K  + L + +  +     V  +
Sbjct: 573 CIHTLT--GHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCL 630

Query: 430 E-EKQVVLTASIDGSVRLWHALNGHY 454
           +  K  V+T+S DG+V+LW    G +
Sbjct: 631 QFNKNFVITSSDDGTVKLWDLKTGEF 656


>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
           sapiens]
          Length = 627

 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 56/250 (22%), Positives = 112/250 (44%), Gaps = 34/250 (13%)

Query: 53  VKANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRV 112
           ++ N+I++G  D+ +++W+     + +  L GH  ++  +  +EK   VVS S     RV
Sbjct: 349 MRDNIIISGSTDRTLKVWNAETG-ECIHTLYGHTSTVRCMHLHEK--RVVSGSRDATLRV 405

Query: 113 WDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQD--TKQV 170
           WDI+T   L V          +Q     YD     +++G+     Y     + D  T+  
Sbjct: 406 WDIETGQCLHVLMGHVAAVRCVQ-----YDGRR--VVSGA-----YDFMVKVWDPETETC 453

Query: 171 PHTHEREINVMLYNKYFHQVLTICS--ESIIRVWELETGLQVYQILEPHGFNTEVTSAAV 228
            HT +   N  +Y+  F  +  +    ++ IRVW++ETG  ++ +        +  ++ +
Sbjct: 454 LHTLQGHTN-RVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLT-----GHQSLTSGM 507

Query: 229 DESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDWKEDEHCLRRLIFLKAQEKHQQLVL 288
           +    +  +G  + TV+IWD  +GQ ++ L      +    CL         + ++  V+
Sbjct: 508 ELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCL---------QFNKNFVI 558

Query: 289 ALERNGTIKM 298
               +GT+K+
Sbjct: 559 TSSDDGTVKL 568



 Score = 38.9 bits (89), Expect = 0.015
 Identities = 50/266 (18%), Positives = 113/266 (42%), Gaps = 44/266 (16%)

Query: 190 VLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIWDF 249
           +++  ++  ++VW  ETG  ++ +   +G  + V    + E   +  +G+ + T+R+WD 
Sbjct: 354 IISGSTDRTLKVWNAETGECIHTL---YGHTSTVRCMHLHEKRVV--SGSRDATLRVWDI 408

Query: 250 GSGQEMKVLPEGKDWKEDEHCLRRLIFLKAQEKHQQLVLALERNGTIKMIQGKEDDIYLM 309
            +GQ                CL  L+       H   V  ++ +G  +++ G  D  +++
Sbjct: 409 ETGQ----------------CLHVLM------GHVAAVRCVQYDGR-RVVSGAYD--FMV 443

Query: 310 VIWELPDVVPFLQDGKHAVHLRMSTRDRNMAIPFPDVELIVERNFSQPTDNPTMDLLRVN 369
            +W+         + +  +H      +R  ++ F  + ++   + S  T     D+   N
Sbjct: 444 KVWD--------PETETCLHTLQGHTNRVYSLQFDGIHVV---SGSLDTSIRVWDVETGN 492

Query: 370 CIDLLQVEGYNLIAAGTLNEGHVILCNISSFLDPPHDEKKFKQLLSWRAHSLEIIQVIYV 429
           CI  L   G+  + +G   + ++++   +       D K  + L + +  +     V  +
Sbjct: 493 CIHTLT--GHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCL 550

Query: 430 E-EKQVVLTASIDGSVRLWHALNGHY 454
           +  K  V+T+S DG+V+LW    G +
Sbjct: 551 QFNKNFVITSSDDGTVKLWDLKTGEF 576


>gi|16445438 bromodomain and WD repeat domain containing 1 isoform B
           [Homo sapiens]
          Length = 2269

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 58/288 (20%), Positives = 123/288 (42%), Gaps = 32/288 (11%)

Query: 51  YCVK----ANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSS 106
           YCV      + I TG DD ++++W  + + + +  L GH   I+++  N ++  + + S 
Sbjct: 190 YCVAFDRTGHRIFTGSDDCLVKIWSTH-NGRLLSTLRGHSAEISDMAVNYENTMIAAGSC 248

Query: 107 AKVFRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSS---VMDMYPLTRM 163
            K+ RVW ++T + + V     G    +Q   M   +   M+ TG+        + L  +
Sbjct: 249 DKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESL 308

Query: 164 IQDTKQVPHTHEREINVMLYNKYFHQ----VLTICSESIIRVWELETGLQV-YQILEPHG 218
               + +  T +    V +    F      + T  ++ +IR++ L  G +   +I E   
Sbjct: 309 KFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFL--GFEAPEKIAELES 366

Query: 219 FNTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPE------GKDWKEDEHCLR 272
              +V S     +G  F +G+ +GT RIW F   +   +L +      G    E+E  ++
Sbjct: 367 HTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEERFMK 426

Query: 273 RLIFLKAQEKHQQLVLALERNGTIKM-----------IQGKEDDIYLM 309
             + + A  ++  +V+    +  +K+           + G  D+++++
Sbjct: 427 PKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVL 474



 Score = 37.7 bits (86), Expect = 0.033
 Identities = 50/236 (21%), Positives = 89/236 (37%), Gaps = 39/236 (16%)

Query: 25  LESLKRLEDNLPVREFSMPRGANTFC--YCVKANVIVTGGDDKVIRLWHPNIST-KPVGK 81
           LESLK     L   E   P G    C  + V    + TG  D VIR++       + + +
Sbjct: 305 LESLKFSPRPLKFTEKPRP-GVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAE 363

Query: 82  LVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIY 141
           L  H   +  I         +S S     R+W  + L    +                  
Sbjct: 364 LESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSI------------------ 405

Query: 142 DANHGMLITGSSVMDMYPLTRMIQD-TKQVPHTHEREINVMLYNKYFHQVLTICSESIIR 200
                       ++DM   TR+  D + +     + ++ ++ +N+    V+T  ++ +++
Sbjct: 406 ------------LLDM--ATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLK 451

Query: 201 VWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMK 256
           VW   TG Q+   L  H     V      +S  + + G ++G++ IWD   G +MK
Sbjct: 452 VWNSYTG-QLLHNLMGHADEVFVLETHPFDSRIMLSAG-HDGSIFIWDITKGTKMK 505



 Score = 34.3 bits (77), Expect = 0.36
 Identities = 20/110 (18%), Positives = 47/110 (42%), Gaps = 5/110 (4%)

Query: 140 IYDANHGMLITGSSVMDMYPLTRMIQDTKQVPHT--HEREINVMLYNKYFHQVLTICSES 197
           + + + G  +TG S         M Q  K       H   +  + +++  H++ T   + 
Sbjct: 149 LVEIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDC 208

Query: 198 IIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIW 247
           ++++W    G  +  +    G + E++  AV+    + A G+ +  +R+W
Sbjct: 209 LVKIWSTHNGRLLSTL---RGHSAEISDMAVNYENTMIAAGSCDKIIRVW 255


>gi|16445436 bromodomain and WD repeat domain containing 1 isoform A
           [Homo sapiens]
          Length = 2320

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 58/288 (20%), Positives = 123/288 (42%), Gaps = 32/288 (11%)

Query: 51  YCVK----ANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSS 106
           YCV      + I TG DD ++++W  + + + +  L GH   I+++  N ++  + + S 
Sbjct: 190 YCVAFDRTGHRIFTGSDDCLVKIWSTH-NGRLLSTLRGHSAEISDMAVNYENTMIAAGSC 248

Query: 107 AKVFRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSS---VMDMYPLTRM 163
            K+ RVW ++T + + V     G    +Q   M   +   M+ TG+        + L  +
Sbjct: 249 DKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESL 308

Query: 164 IQDTKQVPHTHEREINVMLYNKYFHQ----VLTICSESIIRVWELETGLQV-YQILEPHG 218
               + +  T +    V +    F      + T  ++ +IR++ L  G +   +I E   
Sbjct: 309 KFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFL--GFEAPEKIAELES 366

Query: 219 FNTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPE------GKDWKEDEHCLR 272
              +V S     +G  F +G+ +GT RIW F   +   +L +      G    E+E  ++
Sbjct: 367 HTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEERFMK 426

Query: 273 RLIFLKAQEKHQQLVLALERNGTIKM-----------IQGKEDDIYLM 309
             + + A  ++  +V+    +  +K+           + G  D+++++
Sbjct: 427 PKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVL 474



 Score = 37.7 bits (86), Expect = 0.033
 Identities = 50/236 (21%), Positives = 89/236 (37%), Gaps = 39/236 (16%)

Query: 25  LESLKRLEDNLPVREFSMPRGANTFC--YCVKANVIVTGGDDKVIRLWHPNIST-KPVGK 81
           LESLK     L   E   P G    C  + V    + TG  D VIR++       + + +
Sbjct: 305 LESLKFSPRPLKFTEKPRP-GVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAE 363

Query: 82  LVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIY 141
           L  H   +  I         +S S     R+W  + L    +                  
Sbjct: 364 LESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSI------------------ 405

Query: 142 DANHGMLITGSSVMDMYPLTRMIQD-TKQVPHTHEREINVMLYNKYFHQVLTICSESIIR 200
                       ++DM   TR+  D + +     + ++ ++ +N+    V+T  ++ +++
Sbjct: 406 ------------LLDM--ATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLK 451

Query: 201 VWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMK 256
           VW   TG Q+   L  H     V      +S  + + G ++G++ IWD   G +MK
Sbjct: 452 VWNSYTG-QLLHNLMGHADEVFVLETHPFDSRIMLSAG-HDGSIFIWDITKGTKMK 505



 Score = 34.3 bits (77), Expect = 0.36
 Identities = 20/110 (18%), Positives = 47/110 (42%), Gaps = 5/110 (4%)

Query: 140 IYDANHGMLITGSSVMDMYPLTRMIQDTKQVPHT--HEREINVMLYNKYFHQVLTICSES 197
           + + + G  +TG S         M Q  K       H   +  + +++  H++ T   + 
Sbjct: 149 LVEIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDC 208

Query: 198 IIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIW 247
           ++++W    G  +  +    G + E++  AV+    + A G+ +  +R+W
Sbjct: 209 LVKIWSTHNGRLLSTL---RGHSAEISDMAVNYENTMIAAGSCDKIIRVW 255


>gi|48928050 F-box and WD repeat domain containing 11 isoform C
           [Homo sapiens]
          Length = 542

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 57/277 (20%), Positives = 118/277 (42%), Gaps = 30/277 (10%)

Query: 47  NTFCYCVKANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSS 106
           +  C      VIVTG  D  +R+W  N + + +  L+ H  ++  +     +  +V+ S 
Sbjct: 282 SVLCLQYDERVIVTGSSDSTVRVWDVN-TGEVLNTLIHHNEAVLHL--RFSNGLMVTCSK 338

Query: 107 AKVFRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQD 166
            +   VWD+ + + + +     G    + +    +D  + +  +G   + ++  +    +
Sbjct: 339 DRSIAVWDMASATDITLRRVLVGHRAAVNVVD--FDDKYIVSASGDRTIKVWSTSTC--E 394

Query: 167 TKQVPHTHEREINVMLYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSA 226
             +  + H+R I  + Y      V++  S++ IR+W++E G    ++LE H    E    
Sbjct: 395 FVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECG-ACLRVLEGH----EELVR 447

Query: 227 AVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDWKEDEHCLRRLIFLKAQEKHQQL 286
            +        +GAY+G +++WD  +  + +             CLR L+      +H   
Sbjct: 448 CIRFDNKRIVSGAYDGKIKVWDLQAALDPRA-------PASTLCLRTLV------EHSGR 494

Query: 287 VLALERNGTIKMIQGKEDDIYLMVIWELPDVVPFLQD 323
           V  L+ +   ++I    DD  L  IW+  +V P  Q+
Sbjct: 495 VFRLQFD-EFQIISSSHDDTIL--IWDFLNVPPSAQN 528



 Score = 33.1 bits (74), Expect = 0.80
 Identities = 18/70 (25%), Positives = 38/70 (54%), Gaps = 5/70 (7%)

Query: 189 QVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIWD 248
           ++++   ++ I++W+ +T L+  ++L  H     V     DE   +  TG+ + TVR+WD
Sbjct: 252 KIISGLRDNSIKIWD-KTSLECLKVLTGH--TGSVLCLQYDER--VIVTGSSDSTVRVWD 306

Query: 249 FGSGQEMKVL 258
             +G+ +  L
Sbjct: 307 VNTGEVLNTL 316


>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
          Length = 357

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 47/208 (22%), Positives = 85/208 (40%), Gaps = 24/208 (11%)

Query: 51  YCVK----ANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSS 106
           YC K     + + + G D++I LW+          L GH  ++ E+  N     + S S+
Sbjct: 70  YCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSAST 129

Query: 107 AKVFRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHG--MLITGS--SVMDMYPLTR 162
            K   VWD +T   ++         G     +  Y A  G  ++ TGS    + ++ + +
Sbjct: 130 DKTVAVWDSETGERVKRL------KGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRK 183

Query: 163 MIQDTKQVPHTHEREINVM--LYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFN 220
                K    T +    V+   +N    Q+++   ++ I+VW+L      Y +    G  
Sbjct: 184 -----KAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTM---RGHA 235

Query: 221 TEVTSAAVDESGFLFATGAYNGTVRIWD 248
             VT  ++   G    + A + TVR+WD
Sbjct: 236 DSVTGLSLSSEGSYLLSNAMDNTVRVWD 263



 Score = 38.9 bits (89), Expect = 0.015
 Identities = 37/216 (17%), Positives = 84/216 (38%), Gaps = 15/216 (6%)

Query: 51  YCVKANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAK-V 109
           Y    +++ +   DK + +W      + V +L GH   +       +   +V   S    
Sbjct: 117 YNTDGSMLFSASTDKTVAVWDSETGER-VKRLKGHTSFVNSCYPARRGPQLVCTGSDDGT 175

Query: 110 FRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTKQ 169
            ++WDI+  + +Q F ++       Q+ ++ ++     +I+G    D+            
Sbjct: 176 VKLWDIRKKAAIQTFQNTY------QVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTY 229

Query: 170 VPHTHEREINVMLYNKYFHQVLTICSESIIRVWEL------ETGLQVYQILEPHGFNTEV 223
               H   +  +  +     +L+   ++ +RVW++      E  ++++Q    H F   +
Sbjct: 230 TMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQG-NVHNFEKNL 288

Query: 224 TSAAVDESGFLFATGAYNGTVRIWDFGSGQEMKVLP 259
              +    G   A G+ +  V +WD  S + +  LP
Sbjct: 289 LRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLP 324



 Score = 29.6 bits (65), Expect = 8.9
 Identities = 18/59 (30%), Positives = 30/59 (50%), Gaps = 1/59 (1%)

Query: 58  IVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQ 116
           I  G  D+ + +W    S + + KL GH  SI E+  +  +  ++S SS K   + +IQ
Sbjct: 300 IAAGSADRFVYVWDTT-SRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357


>gi|48928048 F-box and WD repeat domain containing 11 isoform A
           [Homo sapiens]
          Length = 508

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 57/277 (20%), Positives = 118/277 (42%), Gaps = 30/277 (10%)

Query: 47  NTFCYCVKANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSS 106
           +  C      VIVTG  D  +R+W  N + + +  L+ H  ++  +     +  +V+ S 
Sbjct: 248 SVLCLQYDERVIVTGSSDSTVRVWDVN-TGEVLNTLIHHNEAVLHL--RFSNGLMVTCSK 304

Query: 107 AKVFRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQD 166
            +   VWD+ + + + +     G    + +    +D  + +  +G   + ++  +    +
Sbjct: 305 DRSIAVWDMASATDITLRRVLVGHRAAVNVVD--FDDKYIVSASGDRTIKVWSTSTC--E 360

Query: 167 TKQVPHTHEREINVMLYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSA 226
             +  + H+R I  + Y      V++  S++ IR+W++E G    ++LE H    E    
Sbjct: 361 FVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECG-ACLRVLEGH----EELVR 413

Query: 227 AVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDWKEDEHCLRRLIFLKAQEKHQQL 286
            +        +GAY+G +++WD  +  + +             CLR L+      +H   
Sbjct: 414 CIRFDNKRIVSGAYDGKIKVWDLQAALDPRA-------PASTLCLRTLV------EHSGR 460

Query: 287 VLALERNGTIKMIQGKEDDIYLMVIWELPDVVPFLQD 323
           V  L+ +   ++I    DD  L  IW+  +V P  Q+
Sbjct: 461 VFRLQFD-EFQIISSSHDDTIL--IWDFLNVPPSAQN 494



 Score = 33.1 bits (74), Expect = 0.80
 Identities = 18/70 (25%), Positives = 38/70 (54%), Gaps = 5/70 (7%)

Query: 189 QVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIWD 248
           ++++   ++ I++W+ +T L+  ++L  H     V     DE   +  TG+ + TVR+WD
Sbjct: 218 KIISGLRDNSIKIWD-KTSLECLKVLTGH--TGSVLCLQYDER--VIVTGSSDSTVRVWD 272

Query: 249 FGSGQEMKVL 258
             +G+ +  L
Sbjct: 273 VNTGEVLNTL 282


>gi|48928046 F-box and WD repeat domain containing 11 isoform B
           [Homo sapiens]
          Length = 529

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 57/277 (20%), Positives = 118/277 (42%), Gaps = 30/277 (10%)

Query: 47  NTFCYCVKANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSS 106
           +  C      VIVTG  D  +R+W  N + + +  L+ H  ++  +     +  +V+ S 
Sbjct: 269 SVLCLQYDERVIVTGSSDSTVRVWDVN-TGEVLNTLIHHNEAVLHL--RFSNGLMVTCSK 325

Query: 107 AKVFRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQD 166
            +   VWD+ + + + +     G    + +    +D  + +  +G   + ++  +    +
Sbjct: 326 DRSIAVWDMASATDITLRRVLVGHRAAVNVVD--FDDKYIVSASGDRTIKVWSTSTC--E 381

Query: 167 TKQVPHTHEREINVMLYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSA 226
             +  + H+R I  + Y      V++  S++ IR+W++E G    ++LE H    E    
Sbjct: 382 FVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECG-ACLRVLEGH----EELVR 434

Query: 227 AVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDWKEDEHCLRRLIFLKAQEKHQQL 286
            +        +GAY+G +++WD  +  + +             CLR L+      +H   
Sbjct: 435 CIRFDNKRIVSGAYDGKIKVWDLQAALDPRA-------PASTLCLRTLV------EHSGR 481

Query: 287 VLALERNGTIKMIQGKEDDIYLMVIWELPDVVPFLQD 323
           V  L+ +   ++I    DD  L  IW+  +V P  Q+
Sbjct: 482 VFRLQFD-EFQIISSSHDDTIL--IWDFLNVPPSAQN 515



 Score = 33.1 bits (74), Expect = 0.80
 Identities = 18/70 (25%), Positives = 38/70 (54%), Gaps = 5/70 (7%)

Query: 189 QVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIWD 248
           ++++   ++ I++W+ +T L+  ++L  H     V     DE   +  TG+ + TVR+WD
Sbjct: 239 KIISGLRDNSIKIWD-KTSLECLKVLTGH--TGSVLCLQYDER--VIVTGSSDSTVRVWD 293

Query: 249 FGSGQEMKVL 258
             +G+ +  L
Sbjct: 294 VNTGEVLNTL 303


>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
           sapiens]
          Length = 472

 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 45/220 (20%), Positives = 95/220 (43%), Gaps = 32/220 (14%)

Query: 47  NTFCYCVKANVIVTGGDDKVIRLWHP-------NISTKPVGKLVGHMFSIAEIVTNEKDQ 99
           +T  +CV    +++G  D  ++LW P       +   +P   +V       E        
Sbjct: 106 STCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVV-------ECSITGDSS 158

Query: 100 HVVSLSSAKVFRVWDIQTLSLL-QVFHDS-----QGGPGDMQIYSMIYDANHGMLITGSS 153
            V++ S  K  R WD++T  LL +V +D+     +  P    + S  +D +HG+ I    
Sbjct: 159 RVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSG-FDVDHGICI---- 213

Query: 154 VMDMYPLTRMIQDTKQVPHTHEREINVMLYNKYFHQVLTICSESIIRVWELETGLQVYQI 213
            MD   +T +      +   H R I    ++    +V ++  +  I++W++ +   +  I
Sbjct: 214 -MDAENITTV----SVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTI 268

Query: 214 LEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQ 253
            + H  +  +++     SG    T +++  ++IW+  +G+
Sbjct: 269 TKAH--SNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGE 306



 Score = 31.6 bits (70), Expect = 2.3
 Identities = 14/75 (18%), Positives = 40/75 (53%), Gaps = 2/75 (2%)

Query: 45  GANTFCYCVK-ANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVS 103
           G+ + C+  + ++ +++GG D+ + +W      + +  L GH   + ++  +   + ++S
Sbjct: 322 GSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLS-LKGHNDWVMDVAISNNKKWILS 380

Query: 104 LSSAKVFRVWDIQTL 118
            S  +  R+W+I+ +
Sbjct: 381 ASKDRTMRLWNIEEI 395


>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
           [Homo sapiens]
          Length = 514

 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 52/249 (20%), Positives = 102/249 (40%), Gaps = 25/249 (10%)

Query: 62  GDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSLL 121
           G+DK ++ W    + K +    GH+ ++  +  +     +V+ S     R+WD++T + +
Sbjct: 265 GEDKQVKCWDLEYN-KVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASV 323

Query: 122 QVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTKQVPHTHEREINVM 181
                       ++       A    +ITGS    +     +   T+     H++ +  +
Sbjct: 324 HTLSGHTNAVATVRC-----QAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAV 378

Query: 182 LYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAYN 241
           + +   H      S   I+ W+   G  +  +    G N  + +  V+  G L  +GA N
Sbjct: 379 VLHPR-HYTFASGSPDNIKQWKFPDGSFIQNL---SGHNAIINTLTVNSDGVL-VSGADN 433

Query: 242 GTVRIWDFGSGQEMK-----VLPEGKDWKEDEHCLRRLIFLKAQEKHQQLVLALERNGTI 296
           GT+ +WD+ +G   +     V P   D +         IF  A ++ +  +L  E + TI
Sbjct: 434 GTMHLWDWRTGYNFQRVHAAVQPGSLDSESG-------IFACAFDQSESRLLTAEADKTI 486

Query: 297 KMIQGKEDD 305
           K+   +EDD
Sbjct: 487 KVY--REDD 493


>gi|153791630 bromodomain and WD repeat domain containing 3 [Homo
           sapiens]
          Length = 1802

 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 56/290 (19%), Positives = 115/290 (39%), Gaps = 33/290 (11%)

Query: 51  YCV----KANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSS 106
           YCV        I TG DD ++++W  +   + +  L GH   I+++  N ++  + + S 
Sbjct: 184 YCVAFDRSGRRIFTGSDDCLVKIWATD-DGRLLATLRGHSAEISDMAVNYENTLIAAGSC 242

Query: 107 AKVFRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSS----VMDMYPLTR 162
            KV RVW ++T + + V          +Q        N  +  TG+         +  T 
Sbjct: 243 DKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHVKTM 302

Query: 163 MIQDTKQVPHTHEREINVMLYNKYFHQ----VLTICSESIIRVWELETGL-QVYQILEPH 217
             +D + V  T      V +    F      + T  ++ +IR++ L + + +    LE H
Sbjct: 303 KFRD-RPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAELESH 361

Query: 218 GFNTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQ------EMKVLPEGKDWKEDEHCL 271
                      +     F +G+ +GT RIW +   +      +M     G +    E  +
Sbjct: 362 TDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKI 421

Query: 272 RRL-IFLKAQEKHQQLVLALERNGTIKM-----------IQGKEDDIYLM 309
            +L + + A +++   V+    N  +K+           + G +D+++++
Sbjct: 422 TKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVL 471


>gi|21536371 telomerase-associated protein 1 [Homo sapiens]
          Length = 2627

 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 46/200 (23%), Positives = 85/200 (42%), Gaps = 45/200 (22%)

Query: 48   TFCYCVKANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSA 107
            T C   K N++++   D  + LW P  S + +G+ +GH  +++ +   E  +HVVS+S  
Sbjct: 2111 TGCAWTKDNLLISCSSDGSVGLWDPE-SGQRLGQFLGHQSAVSAVAAVE--EHVVSVSRD 2167

Query: 108  KVFRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDT 167
               +VWD Q + L  +                   A+ G +   ++ M+           
Sbjct: 2168 GTLKVWDHQGVELTSI------------------PAHSGPISHCAAAME----------- 2198

Query: 168  KQVPHTHEREINVMLYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAA 227
               P    +  + +L       V+T+  +   R+W      Q + +L   G +  V +AA
Sbjct: 2199 ---PRAAGQPGSELL-------VVTVGLDGATRLWHPLLVCQTHTLL---GHSGPVRAAA 2245

Query: 228  VDESGFLFATGAYNGTVRIW 247
            V E+  L  T + +G+VR+W
Sbjct: 2246 VSETSGLMLTASEDGSVRLW 2265



 Score = 29.6 bits (65), Expect = 8.9
 Identities = 16/59 (27%), Positives = 28/59 (47%), Gaps = 1/59 (1%)

Query: 57   VIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDI 115
            ++VT G D   RLWHP +  +    L+GH   +     +E    +++ S     R+W +
Sbjct: 2210 LVVTVGLDGATRLWHPLLVCQ-THTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQV 2267


>gi|4502477 beta-transducin repeat containing protein isoform 2
           [Homo sapiens]
          Length = 569

 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 55/267 (20%), Positives = 116/267 (43%), Gaps = 30/267 (11%)

Query: 47  NTFCYCVKANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSS 106
           +  C      VI+TG  D  +R+W  N + + +  L+ H  ++  +  N  +  +V+ S 
Sbjct: 309 SVLCLQYDERVIITGSSDSTVRVWDVN-TGEMLNTLIHHCEAVLHLRFN--NGMMVTCSK 365

Query: 107 AKVFRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQD 166
            +   VWD+ + + + +     G    + +    +D  + +  +G   + ++  +    +
Sbjct: 366 DRSIAVWDMASPTDITLRRVLVGHRAAVNVVD--FDDKYIVSASGDRTIKVWNTSTC--E 421

Query: 167 TKQVPHTHEREINVMLYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSA 226
             +  + H+R I  + Y      V++  S++ IR+W++E G    ++LE H    E    
Sbjct: 422 FVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECG-ACLRVLEGH----EELVR 474

Query: 227 AVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDWKEDEHCLRRLIFLKAQEKHQQL 286
            +        +GAY+G +++WD  +  + +  P G        CLR L+      +H   
Sbjct: 475 CIRFDNKRIVSGAYDGKIKVWDLVAALDPRA-PAG------TLCLRTLV------EHSGR 521

Query: 287 VLALERNGTIKMIQGKEDDIYLMVIWE 313
           V  L+ +   +++    DD  L  IW+
Sbjct: 522 VFRLQFD-EFQIVSSSHDDTIL--IWD 545



 Score = 33.1 bits (74), Expect = 0.80
 Identities = 47/238 (19%), Positives = 103/238 (43%), Gaps = 33/238 (13%)

Query: 98  DQHVVSLSSAKVFRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSS---- 153
           DQ +VS       ++WD  TL   ++     G      +  + YD    ++ITGSS    
Sbjct: 277 DQKIVSGLRDNTIKIWDKNTLECKRILTGHTG-----SVLCLQYDER--VIITGSSDSTV 329

Query: 154 -VMDMYPLTRMIQDTKQVPHTHEREINVMLYNKYFHQVLTICS-ESIIRVWEL--ETGLQ 209
            V D+        +T ++ +T       +L+ ++ + ++  CS +  I VW++   T + 
Sbjct: 330 RVWDV--------NTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDIT 381

Query: 210 VYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDWKEDEH 269
           + ++L  H     V     D+   + A+G  + T+++W+  + + ++ L      K    
Sbjct: 382 LRRVLVGH--RAAVNVVDFDDKYIVSASG--DRTIKVWNTSTCEFVRTL---NGHKRGIA 434

Query: 270 CL--RRLIFLKAQEKHQQLVLALERNGTIKMIQGKEDDIYLMVIWELPDVVPFLQDGK 325
           CL  R  + +     +   +  +E    +++++G E ++   + ++   +V    DGK
Sbjct: 435 CLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHE-ELVRCIRFDNKRIVSGAYDGK 491


>gi|16117783 beta-transducin repeat containing protein isoform 1
           [Homo sapiens]
          Length = 605

 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 55/267 (20%), Positives = 116/267 (43%), Gaps = 30/267 (11%)

Query: 47  NTFCYCVKANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSS 106
           +  C      VI+TG  D  +R+W  N + + +  L+ H  ++  +  N  +  +V+ S 
Sbjct: 345 SVLCLQYDERVIITGSSDSTVRVWDVN-TGEMLNTLIHHCEAVLHLRFN--NGMMVTCSK 401

Query: 107 AKVFRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQD 166
            +   VWD+ + + + +     G    + +    +D  + +  +G   + ++  +    +
Sbjct: 402 DRSIAVWDMASPTDITLRRVLVGHRAAVNVVD--FDDKYIVSASGDRTIKVWNTSTC--E 457

Query: 167 TKQVPHTHEREINVMLYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSA 226
             +  + H+R I  + Y      V++  S++ IR+W++E G    ++LE H    E    
Sbjct: 458 FVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECG-ACLRVLEGH----EELVR 510

Query: 227 AVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDWKEDEHCLRRLIFLKAQEKHQQL 286
            +        +GAY+G +++WD  +  + +  P G        CLR L+      +H   
Sbjct: 511 CIRFDNKRIVSGAYDGKIKVWDLVAALDPRA-PAG------TLCLRTLV------EHSGR 557

Query: 287 VLALERNGTIKMIQGKEDDIYLMVIWE 313
           V  L+ +   +++    DD  L  IW+
Sbjct: 558 VFRLQFD-EFQIVSSSHDDTIL--IWD 581



 Score = 33.1 bits (74), Expect = 0.80
 Identities = 47/238 (19%), Positives = 103/238 (43%), Gaps = 33/238 (13%)

Query: 98  DQHVVSLSSAKVFRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSS---- 153
           DQ +VS       ++WD  TL   ++     G      +  + YD    ++ITGSS    
Sbjct: 313 DQKIVSGLRDNTIKIWDKNTLECKRILTGHTG-----SVLCLQYDER--VIITGSSDSTV 365

Query: 154 -VMDMYPLTRMIQDTKQVPHTHEREINVMLYNKYFHQVLTICS-ESIIRVWEL--ETGLQ 209
            V D+        +T ++ +T       +L+ ++ + ++  CS +  I VW++   T + 
Sbjct: 366 RVWDV--------NTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDIT 417

Query: 210 VYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDWKEDEH 269
           + ++L  H     V     D+   + A+G  + T+++W+  + + ++ L      K    
Sbjct: 418 LRRVLVGH--RAAVNVVDFDDKYIVSASG--DRTIKVWNTSTCEFVRTL---NGHKRGIA 470

Query: 270 CL--RRLIFLKAQEKHQQLVLALERNGTIKMIQGKEDDIYLMVIWELPDVVPFLQDGK 325
           CL  R  + +     +   +  +E    +++++G E ++   + ++   +V    DGK
Sbjct: 471 CLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHE-ELVRCIRFDNKRIVSGAYDGK 527


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 38/194 (19%), Positives = 81/194 (41%), Gaps = 13/194 (6%)

Query: 57  VIVTGGDDKVIRLWHPNISTKP--VGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWD 114
           ++ TGGDD  + LW  N   KP  +  L GH   +  +  N  ++ +V+ S +   RVWD
Sbjct: 35  LLATGGDDCRVNLWSIN---KPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWD 91

Query: 115 IQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTKQVPHTH 174
           ++   +L+     +       I S+ +      + +GS   ++       +        H
Sbjct: 92  LEAAKILRTLMGHKA-----NICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGH 146

Query: 175 EREINVMLYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFL 234
            + +  + ++     + +   +  +++W+L  G  + +     G    V       + +L
Sbjct: 147 SQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEF---PGHTGPVNVVEFHPNEYL 203

Query: 235 FATGAYNGTVRIWD 248
            A+G+ + T+R WD
Sbjct: 204 LASGSSDRTIRFWD 217



 Score = 33.5 bits (75), Expect = 0.61
 Identities = 35/157 (22%), Positives = 69/157 (43%), Gaps = 19/157 (12%)

Query: 58  IVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQT 117
           + +  DD  ++LW      K + +  GH   +  +  +  +  + S SS +  R WD++ 
Sbjct: 162 LASAADDHTVKLWDLTAG-KMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEK 220

Query: 118 LSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTKQV-PHTHER 176
               QV    +G PG ++  S++++ +   L +G             QD+ +V     ER
Sbjct: 221 ---FQVVSCIEGEPGPVR--SVLFNPDGCCLYSG------------CQDSLRVYGWEPER 263

Query: 177 EINVMLYNKYFHQVLTICSESIIRVWELETGLQVYQI 213
             +V+L N      L IC++ +I V   ++ +  Y +
Sbjct: 264 CFDVVLVNWGKVADLAICNDQLIGVAFSQSNVSSYVV 300


>gi|51242945 striatin, calmodulin binding protein [Homo sapiens]
          Length = 780

 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 55/236 (23%), Positives = 109/236 (46%), Gaps = 26/236 (11%)

Query: 36  PVREFSMPRGANTFCYCVKAN--VIVTGGDDKVIRLWH---PNI----STKPV---GKLV 83
           P+  F   +G    C  + +N     +GG D +I+ W+   PNI    S  P    G L+
Sbjct: 508 PIYTFRAHKGP-VLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLL 566

Query: 84  GHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLS-LLQVFHDSQ--GGPGDMQIYSMI 140
           GH  ++  +  +   Q ++S S+    R+W+   ++  L VF+D++  G P  + + S  
Sbjct: 567 GHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLVSS- 625

Query: 141 YDANHGMLITG---SSVMDMYPLTRMIQDTKQVPHTHER--EINVMLYNKYFHQVLTICS 195
            D +H +       +S+ +M    R++     V  T     +IN ++ +      +T   
Sbjct: 626 -DPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHE 684

Query: 196 ESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIWDFGS 251
           +  I+ ++  TG  ++ ++        VTS AVD +G    +G+++ ++R+W+  S
Sbjct: 685 DRHIKFYDNNTGKLIHSMV---AHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLES 737


>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
           sapiens]
          Length = 522

 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 43/203 (21%), Positives = 87/203 (42%), Gaps = 14/203 (6%)

Query: 64  DKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSLLQV 123
           D  ++LW  + S +PV  + GH   +A ++ +   + + +    + +R+WD++     ++
Sbjct: 302 DGSVKLWSLD-SDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQE--EI 358

Query: 124 FHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTKQVP--HTHEREINVM 181
            H      G   +Y + +  +  +  TG   +D +     ++  + +     H +EI  +
Sbjct: 359 LHQEGHSMG---VYDIAFHQDGSLAGTGG--LDAFGRVWDLRTGRCIMFLEGHLKEIYGI 413

Query: 182 LYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAYN 241
            ++   + + T   ++  +VW+L     VY I       T V    +   G    TGAY+
Sbjct: 414 NFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPI--HGNFLLTGAYD 471

Query: 242 GTVRIWDFGSGQEMKVLP--EGK 262
            T +IW       +K L   EGK
Sbjct: 472 NTAKIWTHPGWSPLKTLAGHEGK 494



 Score = 32.0 bits (71), Expect = 1.8
 Identities = 16/62 (25%), Positives = 30/62 (48%), Gaps = 3/62 (4%)

Query: 53  VKANVIVTGGDDKVIRLW-HPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFR 111
           +  N ++TG  D   ++W HP  S  P+  L GH   +  +  +   Q + + S  + F+
Sbjct: 460 IHGNFLLTGAYDNTAKIWTHPGWS--PLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFK 517

Query: 112 VW 113
           +W
Sbjct: 518 LW 519


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 37/188 (19%), Positives = 85/188 (45%), Gaps = 10/188 (5%)

Query: 71  HPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSLLQVFHDSQGG 130
           +PN + K    LVGH  +++ +  +   + + S S+ ++  +W        +  +     
Sbjct: 28  NPNYALKCT--LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGH--- 82

Query: 131 PGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTKQVPHTHEREINVMLYNKYFHQV 190
             +++I  + + ++   L++ S    +           +    H   +    +N   + +
Sbjct: 83  --NLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLI 140

Query: 191 LTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIWDFG 250
           ++   +  +++WE++TG +  + L  H  +  V++   + SG L  +G+Y+G  RIWD  
Sbjct: 141 ISGSFDETVKIWEVKTG-KCLKTLSAH--SDPVSAVHFNCSGSLIVSGSYDGLCRIWDAA 197

Query: 251 SGQEMKVL 258
           SGQ +K L
Sbjct: 198 SGQCLKTL 205



 Score = 38.5 bits (88), Expect = 0.019
 Identities = 42/211 (19%), Positives = 92/211 (43%), Gaps = 13/211 (6%)

Query: 44  RGANTFCYCVK----ANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQ 99
           +G + + +C      +N+I++G  D+ +++W    + K +  L  H   ++ +  N    
Sbjct: 122 KGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVK-TGKCLKTLSAHSDPVSAVHFNCSGS 180

Query: 100 HVVSLSSAKVFRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYP 159
            +VS S   + R+WD  +   L+   D    P     +S   +  + +  T  + + ++ 
Sbjct: 181 LIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSP--NGKYILTATLDNTLKLWD 238

Query: 160 LTRMIQDTKQVPHTHEREINVMLYNKYFHQVLTICSE-SIIRVWELETGLQVYQILEPHG 218
            +R         H +E+      ++    + +   SE +++ +W L+T  ++ Q L+ H 
Sbjct: 239 YSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT-KEIVQKLQGH- 296

Query: 219 FNTEVTSAAVDESGFLFATGAYNG--TVRIW 247
               V SAA   +  L A+ A     T+++W
Sbjct: 297 -TDVVISAACHPTENLIASAALENDKTIKLW 326



 Score = 33.5 bits (75), Expect = 0.61
 Identities = 34/208 (16%), Positives = 79/208 (37%), Gaps = 50/208 (24%)

Query: 58  IVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQT 117
           +V+  DDK ++LW    S K +  L GH   +     N     ++S S  +  ++W+++T
Sbjct: 98  LVSASDDKTLKLWDVR-SGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKT 156

Query: 118 LSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTKQVPHTHERE 177
              L+    +   P    + ++ ++ +  ++++GS                         
Sbjct: 157 GKCLKTL-SAHSDP----VSAVHFNCSGSLIVSGS------------------------- 186

Query: 178 INVMLYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFAT 237
                             + + R+W+  +G  +  +++    N  V+      +G    T
Sbjct: 187 -----------------YDGLCRIWDAASGQCLKTLVDDD--NPPVSFVKFSPNGKYILT 227

Query: 238 GAYNGTVRIWDFGSGQEMKVLPEGKDWK 265
              + T+++WD+  G+ +K     K+ K
Sbjct: 228 ATLDNTLKLWDYSRGRCLKTYTGHKNEK 255



 Score = 32.3 bits (72), Expect = 1.4
 Identities = 17/90 (18%), Positives = 45/90 (50%), Gaps = 3/90 (3%)

Query: 174 HEREINVMLYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGF 233
           H  EI+ + ++    ++++   +  +++W++ +G  +  +    G +  V     +    
Sbjct: 82  HNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTL---KGHSNYVFCCNFNPPSN 138

Query: 234 LFATGAYNGTVRIWDFGSGQEMKVLPEGKD 263
           L  +G+++ TV+IW+  +G+ +K L    D
Sbjct: 139 LIISGSFDETVKIWEVKTGKCLKTLSAHSD 168


>gi|62234438 Notchless gene homolog isoform b [Homo sapiens]
          Length = 193

 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 32/145 (22%), Positives = 63/145 (43%), Gaps = 5/145 (3%)

Query: 58  IVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQT 117
           +V+G DD  + LW P    KP+ ++ GH   I +++ +   + V S S  K  ++WD +T
Sbjct: 52  LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRT 111

Query: 118 LSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTKQVPHTHERE 177
              L              +Y + + A+  +L++GSS   +       Q        H  E
Sbjct: 112 GKYLASLRGHVAA-----VYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADE 166

Query: 178 INVMLYNKYFHQVLTICSESIIRVW 202
           +  + ++    +V +   +  +R+W
Sbjct: 167 VYAVDWSPDGQRVASGGKDKCLRIW 191



 Score = 35.8 bits (81), Expect = 0.12
 Identities = 19/55 (34%), Positives = 29/55 (52%), Gaps = 2/55 (3%)

Query: 400 FLDPPHDEKKFKQLLSWRAHSLEIIQVIYVEEKQVVLTASIDGSVRLWHALNGHY 454
           FL  P ++KK   L     H   I QV++  + ++V +AS D S++LW    G Y
Sbjct: 62  FLWSPAEDKK--PLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKY 114



 Score = 32.7 bits (73), Expect = 1.0
 Identities = 28/116 (24%), Positives = 47/116 (40%), Gaps = 11/116 (9%)

Query: 148 LITGSSVMDMYPLTRMIQDTKQVPHTHEREINVMLYNKYFHQVLTICSESIIRVWELETG 207
           L   S   D  PLTRM          H+  IN +L++     V +   +  I++W+  TG
Sbjct: 61  LFLWSPAEDKKPLTRMTG--------HQALINQVLFSPDSRIVASASFDKSIKLWDGRTG 112

Query: 208 LQVYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKD 263
             +  +    G    V   A      L  +G+ + T+++WD  + +    LP   D
Sbjct: 113 KYLASL---RGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHAD 165


>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
          Length = 485

 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 32/145 (22%), Positives = 63/145 (43%), Gaps = 5/145 (3%)

Query: 58  IVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQT 117
           +V+G DD  + LW P    KP+ ++ GH   I +++ +   + V S S  K  ++WD +T
Sbjct: 344 LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRT 403

Query: 118 LSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTKQVPHTHERE 177
              L              +Y + + A+  +L++GSS   +       Q        H  E
Sbjct: 404 GKYLASLRGHVAA-----VYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADE 458

Query: 178 INVMLYNKYFHQVLTICSESIIRVW 202
           +  + ++    +V +   +  +R+W
Sbjct: 459 VYAVDWSPDGQRVASGGKDKCLRIW 483



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 66/271 (24%), Positives = 107/271 (39%), Gaps = 49/271 (18%)

Query: 194 CSESIIRVWELETGLQVYQILEPH-----GFNTEVTSAAVDESGFLFATGAYNGTVRIWD 248
           C    I +W+  TG QV + L  H     G + E   A   E  ++ A+ + +G+VRIWD
Sbjct: 175 CKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHAN-PECRYV-ASSSKDGSVRIWD 232

Query: 249 FGSGQEMKVLPEGKDWKEDEHCLRRLIFLKAQEKHQQLVLALERNGTIKMIQGKEDDIYL 308
             +G+  ++L                        H Q V  L   G   +    +D    
Sbjct: 233 TTAGRCERILTG----------------------HTQSVTCLRWGGDGLLYSASQDRT-- 268

Query: 309 MVIWELPDVV--PFLQDGKHAVH-LRMSTRDRNMAIPFPDVELIVERNFSQPTDNPTMD- 364
           + +W   D V    LQ   H V+ + +ST        F   E  V     Q +     + 
Sbjct: 269 IKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKER 328

Query: 365 -LLRVNCIDLLQVEGYNLIAAGTLNEGHVILCNISSFLDPPHDEKKFKQLLSWRAHSLEI 423
            L R N   L++ +G   + +G+         + + FL  P ++KK   L     H   I
Sbjct: 329 ALSRYN---LVRGQGPERLVSGS--------DDFTLFLWSPAEDKK--PLTRMTGHQALI 375

Query: 424 IQVIYVEEKQVVLTASIDGSVRLWHALNGHY 454
            QV++  + ++V +AS D S++LW    G Y
Sbjct: 376 NQVLFSPDSRIVASASFDKSIKLWDGRTGKY 406



 Score = 32.7 bits (73), Expect = 1.0
 Identities = 28/116 (24%), Positives = 47/116 (40%), Gaps = 11/116 (9%)

Query: 148 LITGSSVMDMYPLTRMIQDTKQVPHTHEREINVMLYNKYFHQVLTICSESIIRVWELETG 207
           L   S   D  PLTRM          H+  IN +L++     V +   +  I++W+  TG
Sbjct: 353 LFLWSPAEDKKPLTRMTG--------HQALINQVLFSPDSRIVASASFDKSIKLWDGRTG 404

Query: 208 LQVYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKD 263
             +  +    G    V   A      L  +G+ + T+++WD  + +    LP   D
Sbjct: 405 KYLASL---RGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHAD 457


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 39/199 (19%), Positives = 83/199 (41%), Gaps = 13/199 (6%)

Query: 51  YCVKANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVF 110
           +C      VT  DDK +++W  +   K +  L  H+  +     +   + +VS S  K  
Sbjct: 73  FCSDGQSFVTASDDKTVKVWATH-RQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTV 131

Query: 111 RVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTKQV 170
           ++WD  +   +  + +  G       +    D +       ++ MD       ++  + +
Sbjct: 132 KLWDKSSRECVHSYCEHGG-------FVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLL 184

Query: 171 PH--THEREINVMLYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAV 228
            H   H   +N + ++   + ++T  S+S +++ +L  G  +Y +   HG     T+ A 
Sbjct: 185 QHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTL---HGHQGPATTVAF 241

Query: 229 DESGFLFATGAYNGTVRIW 247
             +G  FA+G  +  V +W
Sbjct: 242 SRTGEYFASGGSDEQVMVW 260



 Score = 32.0 bits (71), Expect = 1.8
 Identities = 17/52 (32%), Positives = 26/52 (50%), Gaps = 3/52 (5%)

Query: 196 ESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIW 247
           +S + VW ++   + Y+     G    VT      SG L A+G+ + TVRIW
Sbjct: 2   DSCLMVWHMKPQSRAYRFT---GHKDAVTCVNFSPSGHLLASGSRDKTVRIW 50


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 39/199 (19%), Positives = 83/199 (41%), Gaps = 13/199 (6%)

Query: 51  YCVKANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVF 110
           +C      VT  DDK +++W  +   K +  L  H+  +     +   + +VS S  K  
Sbjct: 111 FCSDGQSFVTASDDKTVKVWATH-RQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTV 169

Query: 111 RVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTKQV 170
           ++WD  +   +  + +  G       +    D +       ++ MD       ++  + +
Sbjct: 170 KLWDKSSRECVHSYCEHGG-------FVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLL 222

Query: 171 PH--THEREINVMLYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAV 228
            H   H   +N + ++   + ++T  S+S +++ +L  G  +Y +   HG     T+ A 
Sbjct: 223 QHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTL---HGHQGPATTVAF 279

Query: 229 DESGFLFATGAYNGTVRIW 247
             +G  FA+G  +  V +W
Sbjct: 280 SRTGEYFASGGSDEQVMVW 298



 Score = 32.0 bits (71), Expect = 1.8
 Identities = 17/52 (32%), Positives = 26/52 (50%), Gaps = 3/52 (5%)

Query: 196 ESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIW 247
           +S + VW ++   + Y+     G    VT      SG L A+G+ + TVRIW
Sbjct: 40  DSCLMVWHMKPQSRAYRFT---GHKDAVTCVNFSPSGHLLASGSRDKTVRIW 88


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 39/199 (19%), Positives = 83/199 (41%), Gaps = 13/199 (6%)

Query: 51  YCVKANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVF 110
           +C      VT  DDK +++W  +   K +  L  H+  +     +   + +VS S  K  
Sbjct: 111 FCSDGQSFVTASDDKTVKVWATH-RQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTV 169

Query: 111 RVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTKQV 170
           ++WD  +   +  + +  G       +    D +       ++ MD       ++  + +
Sbjct: 170 KLWDKSSRECVHSYCEHGG-------FVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLL 222

Query: 171 PH--THEREINVMLYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAV 228
            H   H   +N + ++   + ++T  S+S +++ +L  G  +Y +   HG     T+ A 
Sbjct: 223 QHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTL---HGHQGPATTVAF 279

Query: 229 DESGFLFATGAYNGTVRIW 247
             +G  FA+G  +  V +W
Sbjct: 280 SRTGEYFASGGSDEQVMVW 298



 Score = 32.0 bits (71), Expect = 1.8
 Identities = 17/52 (32%), Positives = 26/52 (50%), Gaps = 3/52 (5%)

Query: 196 ESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIW 247
           +S + VW ++   + Y+     G    VT      SG L A+G+ + TVRIW
Sbjct: 40  DSCLMVWHMKPQSRAYRFT---GHKDAVTCVNFSPSGHLLASGSRDKTVRIW 88


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.137    0.413 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,299,620
Number of Sequences: 37866
Number of extensions: 1065339
Number of successful extensions: 3488
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 57
Number of HSP's successfully gapped in prelim test: 109
Number of HSP's that attempted gapping in prelim test: 2604
Number of HSP's gapped (non-prelim): 799
length of query: 634
length of database: 18,247,518
effective HSP length: 108
effective length of query: 526
effective length of database: 14,157,990
effective search space: 7447102740
effective search space used: 7447102740
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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