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Search of human proteins with 11545739
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|11545739 F-box and WD repeat domain containing 4 [Homo
sapiens]
(412 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|11545739 F-box and WD repeat domain containing 4 [Homo sapiens] 858 0.0
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 75 1e-13
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 75 1e-13
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 75 1e-13
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 59 1e-08
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 57 2e-08
gi|23199987 WD repeat domain 5B [Homo sapiens] 55 1e-07
gi|5729852 guanine nucleotide-binding protein, beta-5 subunit is... 55 2e-07
gi|20336270 guanine nucleotide-binding protein, beta-5 subunit i... 55 2e-07
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 53 6e-07
gi|16554629 WD repeat domain 5 [Homo sapiens] 52 8e-07
gi|16554627 WD repeat domain 5 [Homo sapiens] 52 8e-07
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 52 1e-06
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 50 3e-06
gi|110815834 F-box and WD-40 domain protein 10 [Homo sapiens] 50 4e-06
gi|157694487 CMT1A duplicated region transcript 1 [Homo sapiens] 50 4e-06
gi|113865883 WD repeat domain 38 [Homo sapiens] 50 5e-06
gi|19913369 transducin beta-like 3 [Homo sapiens] 49 6e-06
gi|45594312 TNF receptor-associated factor 7 [Homo sapiens] 49 8e-06
gi|18874090 WD repeat domain 48 [Homo sapiens] 49 8e-06
gi|4506439 retinoblastoma binding protein 7 [Homo sapiens] 49 1e-05
gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [... 48 1e-05
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 47 2e-05
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 47 2e-05
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 47 2e-05
gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens] 47 4e-05
gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens] 47 4e-05
gi|157266266 WD repeat domain 86 [Homo sapiens] 47 4e-05
gi|207029439 retinoblastoma binding protein 4 isoform c [Homo sa... 46 7e-05
gi|207029415 retinoblastoma binding protein 4 isoform b [Homo sa... 46 7e-05
>gi|11545739 F-box and WD repeat domain containing 4 [Homo sapiens]
Length = 412
Score = 858 bits (2217), Expect = 0.0
Identities = 412/412 (100%), Positives = 412/412 (100%)
Query: 1 MAAAAGEEEEEEEAARESAARPAAGPALWRLPEELLLLICSYLDMRALGRLAQVCRWLRR 60
MAAAAGEEEEEEEAARESAARPAAGPALWRLPEELLLLICSYLDMRALGRLAQVCRWLRR
Sbjct: 1 MAAAAGEEEEEEEAARESAARPAAGPALWRLPEELLLLICSYLDMRALGRLAQVCRWLRR 60
Query: 61 FTSCDLLWRRIARASLNSGFTRLGTDLMTSVPVKERVKVSQNWRLGRCREGILLKWRCSQ 120
FTSCDLLWRRIARASLNSGFTRLGTDLMTSVPVKERVKVSQNWRLGRCREGILLKWRCSQ
Sbjct: 61 FTSCDLLWRRIARASLNSGFTRLGTDLMTSVPVKERVKVSQNWRLGRCREGILLKWRCSQ 120
Query: 121 MPWMQLEDDSLYISQANFILAYQFRPDGASLNRRPLGVFAGHDEDVCHFVLANSHIVSAG 180
MPWMQLEDDSLYISQANFILAYQFRPDGASLNRRPLGVFAGHDEDVCHFVLANSHIVSAG
Sbjct: 121 MPWMQLEDDSLYISQANFILAYQFRPDGASLNRRPLGVFAGHDEDVCHFVLANSHIVSAG 180
Query: 181 GDGKIGIHKIHSTFTVKYSAHEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRLGQCLHT 240
GDGKIGIHKIHSTFTVKYSAHEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRLGQCLHT
Sbjct: 181 GDGKIGIHKIHSTFTVKYSAHEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRLGQCLHT 240
Query: 241 IQTEDRVWSIAISPLLSSFVTGTACCGHFSPLRIWDLNSGQLMTHLGSDFPPGAGVLDVM 300
IQTEDRVWSIAISPLLSSFVTGTACCGHFSPLRIWDLNSGQLMTHLGSDFPPGAGVLDVM
Sbjct: 241 IQTEDRVWSIAISPLLSSFVTGTACCGHFSPLRIWDLNSGQLMTHLGSDFPPGAGVLDVM 300
Query: 301 YESPFTLLSCGYDTYVRYWDLRTSVRKCVMEWEEPHDSTLYCLQTDGNHLLATGSSYYGV 360
YESPFTLLSCGYDTYVRYWDLRTSVRKCVMEWEEPHDSTLYCLQTDGNHLLATGSSYYGV
Sbjct: 301 YESPFTLLSCGYDTYVRYWDLRTSVRKCVMEWEEPHDSTLYCLQTDGNHLLATGSSYYGV 360
Query: 361 VRLWDRRQRACLHAFPLTSTPLSSPVYCLRLTTKHLYAALSYNLHVLDFQNP 412
VRLWDRRQRACLHAFPLTSTPLSSPVYCLRLTTKHLYAALSYNLHVLDFQNP
Sbjct: 361 VRLWDRRQRACLHAFPLTSTPLSSPVYCLRLTTKHLYAALSYNLHVLDFQNP 412
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 75.1 bits (183), Expect = 1e-13
Identities = 91/399 (22%), Positives = 149/399 (37%), Gaps = 96/399 (24%)
Query: 31 LPEELLLLICSYLDMRALGRLAQVCRWLRRFTSCDLLWRRIA-------------RASLN 77
LP+EL L + S+L+ + L + AQ CR+ R +LLWR R +
Sbjct: 166 LPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKVIK 225
Query: 78 SGFTRLGTDLMTSVPVKERVKVSQNWRLGRCREGILLKWR----------CSQMPWMQLE 127
GF S +++ ++ NWR G + +LK C +
Sbjct: 226 PGFIH---SPWKSAYIRQH-RIDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSD 281
Query: 128 DDSLYISQANFILAYQFRPDGASLNRRPLGVFAGHDEDVCHFVLANSHIVSAGGDGKIGI 187
D++L + A + + L GH V + ++ I+S D + +
Sbjct: 282 DNTLKVWSA--------------VTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKV 327
Query: 188 HK------IHSTFTVKYSAHEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRLGQCLHTI 241
IH+ + H V C+ +VSGSRD T +VW + +G QCLH +
Sbjct: 328 WNAETGECIHTLY-----GHTSTVRCMHLHEKRVVSGSRDATLRVWDIETG---QCLHVL 379
Query: 242 QTE-----------DRVWSIAISPLLSSFVTGTACCGHF--------------------- 269
RV S A ++ + T C H
Sbjct: 380 MGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSG 439
Query: 270 ---SPLRIWDLNSGQLMTHLGSDFPPGAGVLDVMYESPFTLLSCGYDTYVRYWDLRTSVR 326
+ +R+WD+ +G + L +G M L+S D+ V+ WD++T
Sbjct: 440 SLDTSIRVWDVETGNCIHTLTGHQSLTSG----MELKDNILVSGNADSTVKIWDIKTGQC 495
Query: 327 KCVMEWEEPHDSTLYCLQTDGNHLLATGSSYYGVVRLWD 365
++ H S + CLQ + N ++ SS G V+LWD
Sbjct: 496 LQTLQGPNKHQSAVTCLQFNKNFVIT--SSDDGTVKLWD 532
Score = 50.8 bits (120), Expect = 2e-06
Identities = 39/157 (24%), Positives = 72/157 (45%), Gaps = 8/157 (5%)
Query: 156 LGVFAGHDEDVCHFVLANSHIVSAGGDGKIGIHKIHSTFTVK-YSAHEQEVNCVDCKGGI 214
L GH V H+VS D I + + + + + H+ + ++ K I
Sbjct: 416 LHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNI 475
Query: 215 IVSGSRDRTAKVWPLASGRLGQCLHTIQTEDRVWS-IAISPLLSSFVTGTACCGHFSPLR 273
+VSG+ D T K+W + + GQCL T+Q ++ S + +FV ++ G ++
Sbjct: 476 LVSGNADSTVKIWDI---KTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDG---TVK 529
Query: 274 IWDLNSGQLMTHLGSDFPPGAGVLDVMYESPFTLLSC 310
+WDL +G+ + +L + G+G + + T L C
Sbjct: 530 LWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVC 566
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 75.1 bits (183), Expect = 1e-13
Identities = 91/399 (22%), Positives = 149/399 (37%), Gaps = 96/399 (24%)
Query: 31 LPEELLLLICSYLDMRALGRLAQVCRWLRRFTSCDLLWRRIA-------------RASLN 77
LP+EL L + S+L+ + L + AQ CR+ R +LLWR R +
Sbjct: 284 LPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKVIK 343
Query: 78 SGFTRLGTDLMTSVPVKERVKVSQNWRLGRCREGILLKWR----------CSQMPWMQLE 127
GF S +++ ++ NWR G + +LK C +
Sbjct: 344 PGFIH---SPWKSAYIRQH-RIDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSD 399
Query: 128 DDSLYISQANFILAYQFRPDGASLNRRPLGVFAGHDEDVCHFVLANSHIVSAGGDGKIGI 187
D++L + A + + L GH V + ++ I+S D + +
Sbjct: 400 DNTLKVWSA--------------VTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKV 445
Query: 188 HK------IHSTFTVKYSAHEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRLGQCLHTI 241
IH+ + H V C+ +VSGSRD T +VW + +G QCLH +
Sbjct: 446 WNAETGECIHTLY-----GHTSTVRCMHLHEKRVVSGSRDATLRVWDIETG---QCLHVL 497
Query: 242 QTE-----------DRVWSIAISPLLSSFVTGTACCGHF--------------------- 269
RV S A ++ + T C H
Sbjct: 498 MGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSG 557
Query: 270 ---SPLRIWDLNSGQLMTHLGSDFPPGAGVLDVMYESPFTLLSCGYDTYVRYWDLRTSVR 326
+ +R+WD+ +G + L +G M L+S D+ V+ WD++T
Sbjct: 558 SLDTSIRVWDVETGNCIHTLTGHQSLTSG----MELKDNILVSGNADSTVKIWDIKTGQC 613
Query: 327 KCVMEWEEPHDSTLYCLQTDGNHLLATGSSYYGVVRLWD 365
++ H S + CLQ + N ++ SS G V+LWD
Sbjct: 614 LQTLQGPNKHQSAVTCLQFNKNFVIT--SSDDGTVKLWD 650
Score = 50.8 bits (120), Expect = 2e-06
Identities = 39/157 (24%), Positives = 72/157 (45%), Gaps = 8/157 (5%)
Query: 156 LGVFAGHDEDVCHFVLANSHIVSAGGDGKIGIHKIHSTFTVK-YSAHEQEVNCVDCKGGI 214
L GH V H+VS D I + + + + + H+ + ++ K I
Sbjct: 534 LHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNI 593
Query: 215 IVSGSRDRTAKVWPLASGRLGQCLHTIQTEDRVWS-IAISPLLSSFVTGTACCGHFSPLR 273
+VSG+ D T K+W + + GQCL T+Q ++ S + +FV ++ G ++
Sbjct: 594 LVSGNADSTVKIWDI---KTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDG---TVK 647
Query: 274 IWDLNSGQLMTHLGSDFPPGAGVLDVMYESPFTLLSC 310
+WDL +G+ + +L + G+G + + T L C
Sbjct: 648 LWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVC 684
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 75.1 bits (183), Expect = 1e-13
Identities = 91/399 (22%), Positives = 149/399 (37%), Gaps = 96/399 (24%)
Query: 31 LPEELLLLICSYLDMRALGRLAQVCRWLRRFTSCDLLWRRIA-------------RASLN 77
LP+EL L + S+L+ + L + AQ CR+ R +LLWR R +
Sbjct: 204 LPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKVIK 263
Query: 78 SGFTRLGTDLMTSVPVKERVKVSQNWRLGRCREGILLKWR----------CSQMPWMQLE 127
GF S +++ ++ NWR G + +LK C +
Sbjct: 264 PGFIH---SPWKSAYIRQH-RIDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSD 319
Query: 128 DDSLYISQANFILAYQFRPDGASLNRRPLGVFAGHDEDVCHFVLANSHIVSAGGDGKIGI 187
D++L + A + + L GH V + ++ I+S D + +
Sbjct: 320 DNTLKVWSA--------------VTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKV 365
Query: 188 HK------IHSTFTVKYSAHEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRLGQCLHTI 241
IH+ + H V C+ +VSGSRD T +VW + +G QCLH +
Sbjct: 366 WNAETGECIHTLY-----GHTSTVRCMHLHEKRVVSGSRDATLRVWDIETG---QCLHVL 417
Query: 242 QTE-----------DRVWSIAISPLLSSFVTGTACCGHF--------------------- 269
RV S A ++ + T C H
Sbjct: 418 MGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSG 477
Query: 270 ---SPLRIWDLNSGQLMTHLGSDFPPGAGVLDVMYESPFTLLSCGYDTYVRYWDLRTSVR 326
+ +R+WD+ +G + L +G M L+S D+ V+ WD++T
Sbjct: 478 SLDTSIRVWDVETGNCIHTLTGHQSLTSG----MELKDNILVSGNADSTVKIWDIKTGQC 533
Query: 327 KCVMEWEEPHDSTLYCLQTDGNHLLATGSSYYGVVRLWD 365
++ H S + CLQ + N ++ SS G V+LWD
Sbjct: 534 LQTLQGPNKHQSAVTCLQFNKNFVIT--SSDDGTVKLWD 570
Score = 50.8 bits (120), Expect = 2e-06
Identities = 39/157 (24%), Positives = 72/157 (45%), Gaps = 8/157 (5%)
Query: 156 LGVFAGHDEDVCHFVLANSHIVSAGGDGKIGIHKIHSTFTVK-YSAHEQEVNCVDCKGGI 214
L GH V H+VS D I + + + + + H+ + ++ K I
Sbjct: 454 LHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNI 513
Query: 215 IVSGSRDRTAKVWPLASGRLGQCLHTIQTEDRVWS-IAISPLLSSFVTGTACCGHFSPLR 273
+VSG+ D T K+W + + GQCL T+Q ++ S + +FV ++ G ++
Sbjct: 514 LVSGNADSTVKIWDI---KTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDG---TVK 567
Query: 274 IWDLNSGQLMTHLGSDFPPGAGVLDVMYESPFTLLSC 310
+WDL +G+ + +L + G+G + + T L C
Sbjct: 568 LWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVC 604
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 58.5 bits (140), Expect = 1e-08
Identities = 52/170 (30%), Positives = 76/170 (44%), Gaps = 15/170 (8%)
Query: 199 SAHEQEVNCVDCKGGI--IVSGSRDRTAKVWPLASGRLGQCL-HTIQTEDRVWSIAISPL 255
S H V C+ + G V+GS DRT K+W LASG+L L I T V SP
Sbjct: 201 SGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPY 260
Query: 256 LSSFVTGTACCGHFSPLRIWDLNSGQLMTHLGSDFPPGAGVLDVMYESPFTLLSCGYDTY 315
L S CG ++ WDL +++ H G LD ++ + L++C D+
Sbjct: 261 LFS-------CGEDKQVKCWDLEYNKVIRHYHGHLSAVYG-LD-LHPTIDVLVTCSRDST 311
Query: 316 VRYWDLRTSVRKCVMEWEEPHDSTLYCLQTDGNHLLATGSSYYGVVRLWD 365
R WD+RT + +T+ C + + TG S+ +RLWD
Sbjct: 312 ARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQ--IITG-SHDTTIRLWD 358
Score = 32.0 bits (71), Expect = 1.1
Identities = 29/127 (22%), Positives = 52/127 (40%), Gaps = 12/127 (9%)
Query: 199 SAHEQEVNCVDCKGGI--IVSGSRDRTAKVWPLASGRLGQCLHTIQTEDRVWSIAISPLL 256
S H V V C+ I++GS D T ++W L +G+ L + V ++ + P
Sbjct: 327 SGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTL--TNHKKSVRAVVLHPRH 384
Query: 257 SSFVTGTACCGHFSPLRIWDLNSGQLMTHLGSDFPPGAGVLDVMYESPFTLLSCGYDTYV 316
+F +G+ ++ W G + +L A + + S L+S + +
Sbjct: 385 YTFASGSP-----DNIKQWKFPDGSFIQNLSGH---NAIINTLTVNSDGVLVSGADNGTM 436
Query: 317 RYWDLRT 323
WD RT
Sbjct: 437 HLWDWRT 443
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 57.4 bits (137), Expect = 2e-08
Identities = 52/190 (27%), Positives = 83/190 (43%), Gaps = 19/190 (10%)
Query: 191 HSTFTVKYSAHEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRLGQCL--HTIQTEDRVW 248
H+T H + +D K + S + D + K+W L S + HT++ +W
Sbjct: 272 HNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMW 331
Query: 249 SIAISPLLSSFVTGTACCGHFSPLRIWDLNSGQLMTHLGSDFPPGAGVLDVMYESPFTLL 308
S GT C + R+WDL + + + H GV D+ + +L
Sbjct: 332 HP------SGRFLGTTC--YDRSWRLWDLEAQEEILHQEGH---SMGVYDIAFHQDGSLA 380
Query: 309 SCG-YDTYVRYWDLRTSVRKCVMEWEEPHDSTLYCLQTDGN-HLLATGSSYYGVVRLWDR 366
G D + R WDLRT +C+M + E H +Y + N + +ATGS ++WD
Sbjct: 381 GTGGLDAFGRVWDLRTG--RCIM-FLEGHLKEIYGINFSPNGYHIATGSGD-NTCKVWDL 436
Query: 367 RQRACLHAFP 376
RQR C++ P
Sbjct: 437 RQRRCVYTIP 446
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 55.1 bits (131), Expect = 1e-07
Identities = 51/176 (28%), Positives = 80/176 (45%), Gaps = 15/176 (8%)
Query: 156 LGVFAGHDEDV--CHFVLANSHIVSAGGDGKIGIHKIHSTFTVK-YSAHEQEVNCV--DC 210
L GH V C+F ++ I+S D + I ++ + +K SAH V+ V +C
Sbjct: 118 LKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNC 177
Query: 211 KGGIIVSGSRDRTAKVWPLASGRLGQCLHTIQTEDR--VWSIAISPLLSSFVTGTACCGH 268
G +IVSGS D ++W AS GQCL T+ +D V + SP +T T
Sbjct: 178 SGSLIVSGSYDGLCRIWDAAS---GQCLKTLVDDDNPPVSFVKFSPNGKYILTATL---- 230
Query: 269 FSPLRIWDLNSGQ-LMTHLGSDFPPGAGVLDVMYESPFTLLSCGYDTYVRYWDLRT 323
+ L++WD + G+ L T+ G + ++S D V W+L+T
Sbjct: 231 DNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT 286
Score = 43.9 bits (102), Expect = 3e-04
Identities = 40/177 (22%), Positives = 79/177 (44%), Gaps = 18/177 (10%)
Query: 215 IVSGSRDRTAKVWPLASGRLGQCLHTIQTEDR-VWSIAISPLLSSFVTGTACCGHFSPLR 273
+VS S D+T K+W + SG+ CL T++ V+ +P + ++G+ ++
Sbjct: 98 LVSASDDKTLKLWDVRSGK---CLKTLKGHSNYVFCCNFNPPSNLIISGS----FDETVK 150
Query: 274 IWDLNSGQLMTHLGSDFPPGAGVLDVMYESPFTLLSCG-YDTYVRYWDLRTSVRKCVMEW 332
IW++ +G+ + L + P V V + +L+ G YD R WD + +C+
Sbjct: 151 IWEVKTGKCLKTLSAHSDP---VSAVHFNCSGSLIVSGSYDGLCRIWDAASG--QCLKTL 205
Query: 333 EEPHDSTLYCLQTDGNHLLATGSSYYGVVRLWDRRQRACLHAFPLTSTPLSSPVYCL 389
+ + + ++ N ++ ++LWD + CL T T + YC+
Sbjct: 206 VDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLK----TYTGHKNEKYCI 258
Score = 34.3 bits (77), Expect = 0.21
Identities = 22/90 (24%), Positives = 44/90 (48%), Gaps = 4/90 (4%)
Query: 296 VLDVMYESPFT-LLSCGYDTYVRYWDLRTSVRKCVMEWEEPHDSTLYCLQTDGNHLLATG 354
+ DV + S + L+S D ++ WD+R+ KC ++ + H + ++C + L
Sbjct: 86 ISDVAWSSDSSRLVSASDDKTLKLWDVRSG--KC-LKTLKGHSNYVFCCNFNPPSNLIIS 142
Query: 355 SSYYGVVRLWDRRQRACLHAFPLTSTPLSS 384
S+ V++W+ + CL S P+S+
Sbjct: 143 GSFDETVKIWEVKTGKCLKTLSAHSDPVSA 172
>gi|5729852 guanine nucleotide-binding protein, beta-5 subunit
isoform a [Homo sapiens]
Length = 353
Score = 54.7 bits (130), Expect = 2e-07
Identities = 55/208 (26%), Positives = 93/208 (44%), Gaps = 24/208 (11%)
Query: 167 CHFVLANSHIVSAGGDGKIGIHKIHSTFTVK-YSAHEQEVNCVDCK----GGIIVSGSRD 221
C F ++ I++A GDG + + S ++ + H +V C+D G VSG D
Sbjct: 159 CSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCD 218
Query: 222 RTAKVWPLASGRLGQCLHTIQT-EDRVWSIAISPLLSSFVTGT--ACCGHFSPLRIWDLN 278
+ A VW + R GQC+ +T E + S+ P +F +G+ A C R++DL
Sbjct: 219 KKAMVWDM---RSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATC------RLYDLR 269
Query: 279 SG-QLMTHLGSDFPPGAGVLDVMYESPFTLLSCGYDTY-VRYWDLRTSVRKCVMEWEEPH 336
+ ++ + GA +D + LL GY+ Y + WD+ R ++ E
Sbjct: 270 ADREVAIYSKESIIFGASSVD--FSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENR 327
Query: 337 DSTLYCLQTDGNHLLATGSSYYGVVRLW 364
STL + DG + S+ +R+W
Sbjct: 328 VSTLR-VSPDGTAFCS--GSWDHTLRVW 352
>gi|20336270 guanine nucleotide-binding protein, beta-5 subunit
isoform b [Homo sapiens]
Length = 395
Score = 54.7 bits (130), Expect = 2e-07
Identities = 55/208 (26%), Positives = 93/208 (44%), Gaps = 24/208 (11%)
Query: 167 CHFVLANSHIVSAGGDGKIGIHKIHSTFTVK-YSAHEQEVNCVDCK----GGIIVSGSRD 221
C F ++ I++A GDG + + S ++ + H +V C+D G VSG D
Sbjct: 201 CSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCD 260
Query: 222 RTAKVWPLASGRLGQCLHTIQT-EDRVWSIAISPLLSSFVTGT--ACCGHFSPLRIWDLN 278
+ A VW + R GQC+ +T E + S+ P +F +G+ A C R++DL
Sbjct: 261 KKAMVWDM---RSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATC------RLYDLR 311
Query: 279 SG-QLMTHLGSDFPPGAGVLDVMYESPFTLLSCGYDTY-VRYWDLRTSVRKCVMEWEEPH 336
+ ++ + GA +D + LL GY+ Y + WD+ R ++ E
Sbjct: 312 ADREVAIYSKESIIFGASSVD--FSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENR 369
Query: 337 DSTLYCLQTDGNHLLATGSSYYGVVRLW 364
STL + DG + S+ +R+W
Sbjct: 370 VSTLR-VSPDGTAFCS--GSWDHTLRVW 394
>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
[Homo sapiens]
Length = 340
Score = 52.8 bits (125), Expect = 6e-07
Identities = 62/217 (28%), Positives = 100/217 (46%), Gaps = 27/217 (12%)
Query: 160 AGHDE--DVCHFVLANSHIVSAGGDGKIGIHKIHS-TFTVKYSAHEQEVNCVDCKGG--I 214
AGH C F L ++ IV++ GD + I + T ++ H +V + +
Sbjct: 140 AGHTGYLSCCRF-LDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRL 198
Query: 215 IVSGSRDRTAKVWPLASGRLGQCLHTIQ-TEDRVWSIAISPLLSSFVTGT--ACCGHFSP 271
VSG+ D +AK+W + R G C T E + +I P ++F TG+ A C
Sbjct: 199 FVSGACDASAKLWDV---REGMCRQTFTGHESDINAICFFPNGNAFATGSDDATC----- 250
Query: 272 LRIWDLNSGQ-LMTHLGSDFPPGAGVLDVMYESPFTLLSCGYDTY-VRYWDLRTSVRKCV 329
R++DL + Q LMT+ + G+ V + LL GYD + WD + R V
Sbjct: 251 -RLFDLRADQELMTYSHDNII--CGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGV 307
Query: 330 MEWEEPHDSTLYCL-QTDGNHLLATGSSYYGVVRLWD 365
+ HD+ + CL TD +ATG S+ +++W+
Sbjct: 308 L---AGHDNRVSCLGVTDDGMAVATG-SWDSFLKIWN 340
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 52.4 bits (124), Expect = 8e-07
Identities = 59/255 (23%), Positives = 105/255 (41%), Gaps = 21/255 (8%)
Query: 141 AYQFRPDGASLNRRPLGVFAGHDEDVCH--FVLANSHIVSAGGDGKIGIHKIHS-TFTVK 197
A Q +P N AGH + V F + S+ D I I + F
Sbjct: 23 ATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKT 82
Query: 198 YSAHEQEVNCV--DCKGGIIVSGSRDRTAKVWPLASGRLGQCLHTIQTEDR-VWSIAISP 254
S H+ ++ V ++VS S D+T K+W ++SG+ CL T++ V+ +P
Sbjct: 83 ISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK---CLKTLKGHSNYVFCCNFNP 139
Query: 255 LLSSFVTGTACCGHFSPLRIWDLNSGQLMTHLGSDFPPGAGVLDVMYESPFTLLSCGYDT 314
+ V+G+ +RIWD+ +G+ + L + P + V ++S YD
Sbjct: 140 QSNLIVSGS----FDESVRIWDVKTGKCLKTLPAHSDPVSAV--HFNRDGSLIVSSSYDG 193
Query: 315 YVRYWDLRTSVRKCVMEWEEPHDSTLYCLQTDGNHLLATGSSYYGVVRLWDRRQRACLHA 374
R WD T+ +C+ + + + ++ N ++ ++LWD + CL
Sbjct: 194 LCRIWD--TASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLK- 250
Query: 375 FPLTSTPLSSPVYCL 389
T T + YC+
Sbjct: 251 ---TYTGHKNEKYCI 262
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 52.4 bits (124), Expect = 8e-07
Identities = 59/255 (23%), Positives = 105/255 (41%), Gaps = 21/255 (8%)
Query: 141 AYQFRPDGASLNRRPLGVFAGHDEDVCH--FVLANSHIVSAGGDGKIGIHKIHS-TFTVK 197
A Q +P N AGH + V F + S+ D I I + F
Sbjct: 23 ATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKT 82
Query: 198 YSAHEQEVNCV--DCKGGIIVSGSRDRTAKVWPLASGRLGQCLHTIQTEDR-VWSIAISP 254
S H+ ++ V ++VS S D+T K+W ++SG+ CL T++ V+ +P
Sbjct: 83 ISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK---CLKTLKGHSNYVFCCNFNP 139
Query: 255 LLSSFVTGTACCGHFSPLRIWDLNSGQLMTHLGSDFPPGAGVLDVMYESPFTLLSCGYDT 314
+ V+G+ +RIWD+ +G+ + L + P + V ++S YD
Sbjct: 140 QSNLIVSGS----FDESVRIWDVKTGKCLKTLPAHSDPVSAV--HFNRDGSLIVSSSYDG 193
Query: 315 YVRYWDLRTSVRKCVMEWEEPHDSTLYCLQTDGNHLLATGSSYYGVVRLWDRRQRACLHA 374
R WD T+ +C+ + + + ++ N ++ ++LWD + CL
Sbjct: 194 LCRIWD--TASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLK- 250
Query: 375 FPLTSTPLSSPVYCL 389
T T + YC+
Sbjct: 251 ---TYTGHKNEKYCI 262
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 51.6 bits (122), Expect = 1e-06
Identities = 59/231 (25%), Positives = 101/231 (43%), Gaps = 34/231 (14%)
Query: 161 GHDEDVCHFVLA--NSHIVSAGGDGKIGIHKIHSTFTVK-YSAHEQEVNCV--DCKGGII 215
GHD +V + HIVSA D I + ++ + + VK ++ H + V V + G +I
Sbjct: 190 GHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLI 249
Query: 216 VSGSRDRTAKVWPLASGRLGQCLHTIQTEDRV-----WSIAISPLLSSFVTGTACCGHFS 270
S S D+T +VW +A+ +C ++ + V W+ S S TG+
Sbjct: 250 ASCSNDQTVRVWVVAT---KECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGK 306
Query: 271 P------------LRIWDLNSGQ-LMTHLGSDFPPGAGVLDVMYESPFT-LLSCGYDTYV 316
P +++WD+++G LMT +G D V V++ S +LSC D +
Sbjct: 307 PGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHD----NWVRGVLFHSGGKFILSCADDKTL 362
Query: 317 RYWDLRTSVRKCVMEWEEPHDSTLYCLQTDGNHLLATGSSYYGVVRLWDRR 367
R WD + ++C M+ H+ + L S V++W+ R
Sbjct: 363 RVWDYKN--KRC-MKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410
Score = 35.4 bits (80), Expect = 0.095
Identities = 49/192 (25%), Positives = 78/192 (40%), Gaps = 22/192 (11%)
Query: 160 AGHDEDVCHFVL--ANSHIVSAGGDGKIGIHKIHS-TFTVKYSAHEQEVNCV--DCKGGI 214
+GH V + S +VSA D I + + F H V + D G +
Sbjct: 105 SGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKL 164
Query: 215 IVSGSRDRTAKVWPLASGRLGQCLHTIQTED-RVWSIAISPLLSSFVTGTACCGHFSPLR 273
+ S S D T K+W +C+ T+ D V S+AI P V+ + ++
Sbjct: 165 LASCSADMTIKLWDFQG---FECIRTMHGHDHNVSSVAIMPNGDHIVSAS----RDKTIK 217
Query: 274 IWDLNSGQ-LMTHLGSDFPPGAGVLDVMYESPFTLL-SCGYDTYVRYWDLRTSVRKCVME 331
+W++ +G + T G V V TL+ SC D VR W + T ++C E
Sbjct: 218 MWEVQTGYCVKTFTGH----REWVRMVRPNQDGTLIASCSNDQTVRVWVVAT--KECKAE 271
Query: 332 WEEPHDSTLYCL 343
E H+ + C+
Sbjct: 272 LRE-HEHVVECI 282
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 50.4 bits (119), Expect = 3e-06
Identities = 58/208 (27%), Positives = 91/208 (43%), Gaps = 23/208 (11%)
Query: 125 QLEDDSLYISQANFILAYQFRPDGASLNRRPLGVFAGHDEDVCHFVLANS--HIVSAGGD 182
Q D L S+ I+ ++ D + P GH V V+++ +S D
Sbjct: 26 QFPDMILSASRDKTIIMWKLTRDETNYGI-PQRALRGHSHFVSDVVISSDGQFALSGSWD 84
Query: 183 GKIGIHKIHS-TFTVKYSAHEQEVNCV--DCKGGIIVSGSRDRTAKVWPLASGRLGQCLH 239
G + + + + T T ++ H ++V V IVSGSRD+T K+W LG C +
Sbjct: 85 GTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLW----NTLGVCKY 140
Query: 240 TIQTEDR---VWSIAISPLLSSFVTGTACCGHFSPLRIWDLNSGQLMT-HLGSDFPPGAG 295
T+Q E V + SP S+ + CG +++W+L + +L T H+G G
Sbjct: 141 TVQDESHSEWVSCVRFSPNSSNPI--IVSCGWDKLVKVWNLANCKLKTNHIGH-----TG 193
Query: 296 VLDVMYESPFTLL--SCGYDTYVRYWDL 321
L+ + SP L S G D WDL
Sbjct: 194 YLNTVTVSPDGSLCASGGKDGQAMLWDL 221
>gi|110815834 F-box and WD-40 domain protein 10 [Homo sapiens]
Length = 1051
Score = 50.1 bits (118), Expect = 4e-06
Identities = 34/142 (23%), Positives = 64/142 (45%), Gaps = 17/142 (11%)
Query: 198 YSAHEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRLGQCLHTIQTEDRVWSIAISP--L 255
+ H+ + C+D +VSG RD KVW + +G+ CL T + +D + + I+ +
Sbjct: 491 FGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGK---CLKTFRHKDPILATRINDTYI 547
Query: 256 LSSFVTGTACCGHFSPLRIWDLNSGQLMTHLGSDFPPGAGVLDVMYESPFTLLSCGYDTY 315
+SS G +++W + QL+ L G + ++ + LLS D
Sbjct: 548 VSSCERGL--------VKVWHIAMAQLVKTLSGH----EGAVKCLFFDQWHLLSGSTDGL 595
Query: 316 VRYWDLRTSVRKCVMEWEEPHD 337
V W + +C+M ++ P +
Sbjct: 596 VMAWSMVGKYERCLMAFKHPKE 617
Score = 39.3 bits (90), Expect = 0.007
Identities = 23/69 (33%), Positives = 33/69 (47%), Gaps = 5/69 (7%)
Query: 307 LLSCGYDTYVRYWDLRTSVRKCVMEWEEPHDSTLYCLQTDGNHLLATGSSYYGVVRLWDR 366
LLS YD +RYWDL++ V + H T+ C+ N L++ G V++WD
Sbjct: 468 LLSGSYDLSIRYWDLKSGVCTRIF---GGHQGTITCMDLCKNRLVSGGRDCQ--VKVWDV 522
Query: 367 RQRACLHAF 375
CL F
Sbjct: 523 DTGKCLKTF 531
Score = 33.1 bits (74), Expect = 0.47
Identities = 19/81 (23%), Positives = 34/81 (41%)
Query: 158 VFAGHDEDVCHFVLANSHIVSAGGDGKIGIHKIHSTFTVKYSAHEQEVNCVDCKGGIIVS 217
+F GH + L + +VS G D ++ + + + +K H+ + IVS
Sbjct: 490 IFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKDPILATRINDTYIVS 549
Query: 218 GSRDRTAKVWPLASGRLGQCL 238
KVW +A +L + L
Sbjct: 550 SCERGLVKVWHIAMAQLVKTL 570
Score = 32.7 bits (73), Expect = 0.62
Identities = 39/179 (21%), Positives = 71/179 (39%), Gaps = 20/179 (11%)
Query: 215 IVSGSRDRTAKVWPLASGRLGQCLHTIQTEDRVWSIAISPLLSSFVTGTACCGHFSPLRI 274
++SGS D + + W L SG + Q + + L+S G +++
Sbjct: 468 LLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSG--------GRDCQVKV 519
Query: 275 WDLNSGQLMTHLGSDFPPGAGVLDVMYESPFTLLSCGYDTYVRYWDLRTSVRKCVMEWEE 334
WD+++G+ + P +L + + SC V+ W + + +++
Sbjct: 520 WDVDTGKCLKTFRHKDP----ILATRINDTYIVSSCERG-LVKVWHIAMAQ---LVKTLS 571
Query: 335 PHDSTLYCLQTDGNHLLATGSSYYGVVRLWDR--RQRACLHAFPLTSTPLSSPVYCLRL 391
H+ + CL D HLL+ S G+V W + CL AF L + LR+
Sbjct: 572 GHEGAVKCLFFDQWHLLS--GSTDGLVMAWSMVGKYERCLMAFKHPKEVLDVSLLFLRV 628
>gi|157694487 CMT1A duplicated region transcript 1 [Homo sapiens]
Length = 752
Score = 50.1 bits (118), Expect = 4e-06
Identities = 34/142 (23%), Positives = 64/142 (45%), Gaps = 17/142 (11%)
Query: 198 YSAHEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRLGQCLHTIQTEDRVWSIAISP--L 255
+ H+ + C+D +VSG RD KVW + +G+ CL T + +D + + I+ +
Sbjct: 491 FGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGK---CLKTFRHKDPILATRINDTYI 547
Query: 256 LSSFVTGTACCGHFSPLRIWDLNSGQLMTHLGSDFPPGAGVLDVMYESPFTLLSCGYDTY 315
+SS G +++W + QL+ L G + ++ + LLS D
Sbjct: 548 VSSCERGL--------VKVWHIAMAQLVKTLSGH----EGAVKCLFFDQWHLLSGSTDGL 595
Query: 316 VRYWDLRTSVRKCVMEWEEPHD 337
V W + +C+M ++ P +
Sbjct: 596 VMAWSMVGKYERCLMAFKHPKE 617
Score = 39.3 bits (90), Expect = 0.007
Identities = 23/69 (33%), Positives = 33/69 (47%), Gaps = 5/69 (7%)
Query: 307 LLSCGYDTYVRYWDLRTSVRKCVMEWEEPHDSTLYCLQTDGNHLLATGSSYYGVVRLWDR 366
LLS YD +RYWDL++ V + H T+ C+ N L++ G V++WD
Sbjct: 468 LLSGSYDLSIRYWDLKSGVCTRIF---GGHQGTITCMDLCKNRLVSGGRDCQ--VKVWDV 522
Query: 367 RQRACLHAF 375
CL F
Sbjct: 523 DTGKCLKTF 531
Score = 33.1 bits (74), Expect = 0.47
Identities = 19/81 (23%), Positives = 34/81 (41%)
Query: 158 VFAGHDEDVCHFVLANSHIVSAGGDGKIGIHKIHSTFTVKYSAHEQEVNCVDCKGGIIVS 217
+F GH + L + +VS G D ++ + + + +K H+ + IVS
Sbjct: 490 IFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKDPILATRINDTYIVS 549
Query: 218 GSRDRTAKVWPLASGRLGQCL 238
KVW +A +L + L
Sbjct: 550 SCERGLVKVWHIAMAQLVKTL 570
Score = 32.7 bits (73), Expect = 0.62
Identities = 39/179 (21%), Positives = 71/179 (39%), Gaps = 20/179 (11%)
Query: 215 IVSGSRDRTAKVWPLASGRLGQCLHTIQTEDRVWSIAISPLLSSFVTGTACCGHFSPLRI 274
++SGS D + + W L SG + Q + + L+S G +++
Sbjct: 468 LLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSG--------GRDCQVKV 519
Query: 275 WDLNSGQLMTHLGSDFPPGAGVLDVMYESPFTLLSCGYDTYVRYWDLRTSVRKCVMEWEE 334
WD+++G+ + P +L + + SC V+ W + + +++
Sbjct: 520 WDVDTGKCLKTFRHKDP----ILATRINDTYIVSSCERG-LVKVWHIAMAQ---LVKTLS 571
Query: 335 PHDSTLYCLQTDGNHLLATGSSYYGVVRLWDR--RQRACLHAFPLTSTPLSSPVYCLRL 391
H+ + CL D HLL+ S G+V W + CL AF L + LR+
Sbjct: 572 GHEGAVKCLFFDQWHLLS--GSTDGLVMAWSMVGKYERCLMAFKHPKEVLDVSLLFLRV 628
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 49.7 bits (117), Expect = 5e-06
Identities = 42/159 (26%), Positives = 71/159 (44%), Gaps = 21/159 (13%)
Query: 212 GGIIVSGSRDRTAKVWPLASGRLGQCLHTIQTEDR-VWSIAISPLLSSFVTGTACCGHFS 270
G + S S D T ++W +A + CL ++ R V +++ SP +G G
Sbjct: 75 GHLFASASCDCTVRLWDVARAK---CLRVLKGHQRSVETVSFSPDSRQLASG----GWDK 127
Query: 271 PLRIWDLNSGQLMTHLGSDFPPGAGVLDVMYESPFT-----LLSCGYDTYVRYWDLRTSV 325
+ +WD+ SGQ++ L G D + S F+ L + +D+ V WDLR
Sbjct: 128 RVMLWDVQSGQMLRLL-------VGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVT 180
Query: 326 RKCVMEWEEPHDSTLYCLQTDGNHLLATGSSYYGVVRLW 364
+ E H + + CL + LLA+G S+ + +W
Sbjct: 181 PAVSHQALEGHSANISCLCYSASGLLASG-SWDKTIHIW 218
Score = 29.3 bits (64), Expect = 6.8
Identities = 45/208 (21%), Positives = 74/208 (35%), Gaps = 17/208 (8%)
Query: 156 LGVFAGHDEDV--CHFVLANSHIVSAGGDGKIGIHKIHSTFTVKYSA-HEQEVNCVDCKG 212
L V GH V F + + S G D ++ + + S ++ H + D
Sbjct: 98 LRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSP 157
Query: 213 GI--IVSGSRDRTAKVWPLASGRLGQCLHTIQTEDRVWSIAISPLLSSFVTGTACCGHFS 270
+ + +GS D T +W L ++ S IS L S +G G +
Sbjct: 158 TVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGH----SANISCLCYS-ASGLLASGSWD 212
Query: 271 P-LRIWDLNSGQLMTHLGSDFPPGAGVLDVMYE-SPFTLLSCGYDTYVRYWDLRTSVRKC 328
+ IW + L+ L V + + L S GY V+ WD T KC
Sbjct: 213 KTIHIWKPTTSSLLIQLKGHV---TWVKSIAFSPDELWLASAGYSRMVKVWDCNTG--KC 267
Query: 329 VMEWEEPHDSTLYCLQTDGNHLLATGSS 356
+ + D C T +L +G++
Sbjct: 268 LETLKGVLDVAHTCAFTPDGKILVSGAA 295
>gi|19913369 transducin beta-like 3 [Homo sapiens]
Length = 808
Score = 49.3 bits (116), Expect = 6e-06
Identities = 52/171 (30%), Positives = 81/171 (47%), Gaps = 23/171 (13%)
Query: 201 HEQEVNCVDCKGG--IIVSGSRDRTAKVWPLASGRLGQCLHTIQTEDR-VWSIAISPLLS 257
H++++N V ++ +GS+DRTAK+W L +L L R +W + SP+
Sbjct: 478 HDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQL---LGVFSGHRRGLWCVQFSPMDQ 534
Query: 258 SFVTGTACCGHFSPLRIWDLNSGQ-LMTHLGSDFPPGAGVLDVMYESPFT-LLSCGYDTY 315
T +A +++W L L T G D A VL V + S T LLS G D
Sbjct: 535 VLATASAD----GTIKLWALQDFSCLKTFEGHD----ASVLKVAFVSRGTQLLSSGSDGL 586
Query: 316 VRYWDLRTSVRKCVMEWEEPHDST--LYCLQTDGNHLLATGSSYYGVVRLW 364
V+ W ++ + +CV + D L+C + D + L TG+S V+ LW
Sbjct: 587 VKLWTIKNN--ECVRTLDAHEDKVWGLHCSRLDDHAL--TGASDSRVI-LW 632
Score = 45.4 bits (106), Expect = 9e-05
Identities = 55/194 (28%), Positives = 83/194 (42%), Gaps = 33/194 (17%)
Query: 199 SAHEQEVNCVDC---KGGIIVSGSRDRTAKVWPLASGRL--------GQCLHTIQTEDR- 246
S H V V C K +V+GS+D T K+WPL L G L QT R
Sbjct: 418 SGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRC 477
Query: 247 ----VWSIAISPLLSSFVTGTACCGHFSPLRIWDLNSGQLMTHLGSDFPPGAGVLDVMYE 302
+ S+AI+P TG+ ++W L QL LG G+ V +
Sbjct: 478 HDKDINSVAIAPNDKLLATGS----QDRTAKLWALPQCQL---LGVFSGHRRGLWCVQF- 529
Query: 303 SPF--TLLSCGYDTYVRYWDLRTSVRKCVMEWEEPHDSTL--YCLQTDGNHLLATGSSYY 358
SP L + D ++ W L+ C+ + E HD+++ + G LL++GS
Sbjct: 530 SPMDQVLATASADGTIKLWALQDF--SCLKTF-EGHDASVLKVAFVSRGTQLLSSGSD-- 584
Query: 359 GVVRLWDRRQRACL 372
G+V+LW + C+
Sbjct: 585 GLVKLWTIKNNECV 598
>gi|45594312 TNF receptor-associated factor 7 [Homo sapiens]
Length = 670
Score = 48.9 bits (115), Expect = 8e-06
Identities = 59/251 (23%), Positives = 100/251 (39%), Gaps = 41/251 (16%)
Query: 174 SHIVSAGGDGKIGIHKIHSTFTVK--YSAHEQEV--NCVDCKGGIIVSGSRDRTAKVWPL 229
SHI + G +G + F K + H+ V CV G ++ SGS D+T KVW
Sbjct: 366 SHINARLNMGILGSYDPQQIFKCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDT 425
Query: 230 ASGRLGQCLHTIQTEDRVWSIAISPLLSSFVTGTACCGHFSPLRIWDLNSGQLMTHLGSD 289
+ +C T++ D + +A+ +G+A C + +WD+ + Q + + +
Sbjct: 426 CT--TYKCQKTLEGHDGI-VLALCIQGCKLYSGSADC----TIIVWDIQNLQKVNTIRAH 478
Query: 290 FPPGAGVLDVMYESPFTLLSCGYDTYVRYWDLRTSVRKCVMEWEEPHDSTLYCLQTDGNH 349
P ++ S +L G ++ WD+ + K E T NH
Sbjct: 479 DNPVCTLV-----SSHNVLFSGSLKAIKVWDIVGTELKLKKE------------LTGLNH 521
Query: 350 ---LLATGSSY-----YGVVRLWDRRQRACLHAFPLTSTPLSSPVYCLRLTTKHLYAALS 401
L SY Y +++WD R C+H + VY + +T H+
Sbjct: 522 WVRALVAAQSYLYSGSYQTIKIWDIRTLDCIHVLQTS----GGSVYSIAVTNHHIVCGTY 577
Query: 402 YNL-HVLDFQN 411
NL HV D ++
Sbjct: 578 ENLIHVWDIES 588
>gi|18874090 WD repeat domain 48 [Homo sapiens]
Length = 677
Score = 48.9 bits (115), Expect = 8e-06
Identities = 54/218 (24%), Positives = 91/218 (41%), Gaps = 24/218 (11%)
Query: 172 ANSHIVSAGGDGKIGIHKIHSTFTVKYSA----HEQEVNCVD--CKGGIIVSGSRDRTAK 225
A + + +AG D I I ++ Y A H VN + C G ++S S D T K
Sbjct: 41 ALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVK 100
Query: 226 VWPLASGRLGQCLHTIQT-EDRVWSIAISPLLSSFVTGTACCGHFSPLRIWDLNSGQLMT 284
VW + G C+ T++T +D V ++A + A G + +WD+N+ +T
Sbjct: 101 VW---NAHKGFCMSTLRTHKDYVKALAYAKDKEL----VASAGLDRQIFLWDVNTLTALT 153
Query: 285 HLGSDFPPG--AGVLDVMYESPFT-----LLSCGYDTYVRYWDLRTSVRKCVMEWEEPHD 337
+ +G D +Y ++S + +R WD RT + ++ +
Sbjct: 154 ASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNV 213
Query: 338 STLYCLQTDGNHLLATGSSYYGVVRLWDRRQRACLHAF 375
L L DG L+ S G +RLW Q+ C+ +
Sbjct: 214 KAL-LLNRDGTQCLSGSSD--GTIRLWSLGQQRCIATY 248
>gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]
Length = 425
Score = 48.5 bits (114), Expect = 1e-05
Identities = 51/192 (26%), Positives = 81/192 (42%), Gaps = 29/192 (15%)
Query: 158 VFAGHD---EDVCHFVLANSHIVSAGGDGKIGIHKIHSTFTVKYS----AHEQEVNCVDC 210
+F GH EDV +L S S D K+ I S T K S AH EVNC+
Sbjct: 221 IFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSF 280
Query: 211 KGG---IIVSGSRDRTAKVWPLASGRLGQCLHTIQT-EDRVWSIAISPLLSSFVTGTACC 266
I+ +GS D+T +W L + +L LHT ++ +D ++ + SP + + A
Sbjct: 281 NPYSEFILATGSADKTVALWDLRNLKLK--LHTFESHKDEIFQVHWSPHNETIL---ASS 335
Query: 267 GHFSPLRIWDLN--SGQLMTHLGSDFPP---------GAGVLDVMY--ESPFTLLSCGYD 313
G L +WDL+ + D PP A + D + P+ + S D
Sbjct: 336 GTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSED 395
Query: 314 TYVRYWDLRTSV 325
++ W + ++
Sbjct: 396 NIMQIWQMAENI 407
>gi|11055998 guanine nucleotide-binding protein, beta-4 subunit
[Homo sapiens]
Length = 340
Score = 48.1 bits (113), Expect = 1e-05
Identities = 57/206 (27%), Positives = 93/206 (45%), Gaps = 21/206 (10%)
Query: 167 CHFVLANSHIVSAGGDGKIGIHKIHSTF-TVKYSAHEQEVNCVDCKGGI--IVSGSRDRT 223
C F L +S IV++ GD + I + T ++ H +V + + VSG+ D +
Sbjct: 149 CRF-LDDSQIVTSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDAS 207
Query: 224 AKVWPLASGRLGQCLHTIQTEDRVWSIAISPLLSSFVTGT--ACCGHFSPLRIWDLNSGQ 281
+K+W + G Q T D + +++ P +F TG+ A C R++DL + Q
Sbjct: 208 SKLWDIRDGMCRQSF-TGHVSD-INAVSFFPNGYAFATGSDDATC------RLFDLRADQ 259
Query: 282 LMTHLGSDFPPGAGVLDVMYESPFTLLSCGYDTY-VRYWDLRTSVRKCVMEWEEPHDSTL 340
+ L S G+ V + LL GYD + WD R V+ HD+ +
Sbjct: 260 ELL-LYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVL---AGHDNRV 315
Query: 341 YCL-QTDGNHLLATGSSYYGVVRLWD 365
CL TD +ATG S+ +R+W+
Sbjct: 316 SCLGVTDDGMAVATG-SWDSFLRIWN 340
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 47.4 bits (111), Expect = 2e-05
Identities = 53/228 (23%), Positives = 94/228 (41%), Gaps = 40/228 (17%)
Query: 156 LGVFAGHDEDVCHFVLANSHIVSAGGDGKIGIHKIHSTFTVKYS----AHEQEVNCVDCK 211
L H+E V H +N +V+ D I + + S + H VN VD
Sbjct: 313 LNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFD 372
Query: 212 GGIIVSGSRDRTAKVWPLASGRLGQCLH-------TIQTEDRVWSIAISPLLSSFVTGTA 264
IVS S DRT KVW ++ + L+ +Q DR+ V+G++
Sbjct: 373 DKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRL-----------VVSGSS 421
Query: 265 CCGHFSPLRIWDLNSGQLMTHLGSDFPPGAGVLDVMYESPFTLLSCGYDTYVRYWDLRTS 324
+ +R+WD+ G + L V + +++ ++S YD ++ WDL+ +
Sbjct: 422 D----NTIRLWDIECGACLRVLEGHEEL---VRCIRFDNK-RIVSGAYDGKIKVWDLQAA 473
Query: 325 V-------RKCVMEWEEPHDSTLYCLQTDGNHLLATGSSYYGVVRLWD 365
+ C+ E H ++ LQ D +++ SS+ + +WD
Sbjct: 474 LDPRAPASTLCLRTLVE-HSGRVFRLQFDEFQIIS--SSHDDTILIWD 518
Score = 45.4 bits (106), Expect = 9e-05
Identities = 84/374 (22%), Positives = 139/374 (37%), Gaps = 39/374 (10%)
Query: 39 ICSYLDMRALGRLAQVCRWLRRFTSCDLLWRRIARASLNSGFTRLGTDLMTSVPVKERVK 98
I SYLD R+L VC+ +R S +LW+++ + + P+ + +
Sbjct: 135 ILSYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTD------------PLWKGLS 182
Query: 99 VSQNWRLGRCREGILLKWRCSQMPWMQLEDDSLYISQANFILAYQFRPDGASLNRRPLGV 158
+ W + L K R + P SLY I + N + +
Sbjct: 183 ERRGW------DQYLFKNRPTDGPPNSFYR-SLYPKIIQDIETIESNWRCGRHNLQRIQC 235
Query: 159 FAGHDEDVCHFVLANSHIVSAGGDGKIGIHKIHSTFTVKY-SAHEQEVNCVDCKGGIIVS 217
+ + + V + I+S D I I S +K + H V C+ +IV+
Sbjct: 236 RSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVT 295
Query: 218 GSRDRTAKVWPLASGRLGQCLHTIQTEDRVWSIAISPLLSSFVTGTACCGHFSPLRIWDL 277
GS D T +VW + +G + L I + V + S L C + +WD+
Sbjct: 296 GSSDSTVRVWDVNTGEVLNTL--IHHNEAVLHLRFSNGL------MVTCSKDRSIAVWDM 347
Query: 278 NSGQLMTHLGSDFPPGAGVLDVMYESPFTLLSCGYDTYVRYWDLRTSVRKCVMEWEEPHD 337
S +T A V V ++ + ++S D ++ W T + H
Sbjct: 348 ASATDITLRRVLVGHRAAVNVVDFDDKY-IVSASGDRTIKVWSTSTCE---FVRTLNGHK 403
Query: 338 STLYCLQTDGNHLLATGSSYYGVVRLWDRRQRACLHAFPLTSTPLSSPVYCLRLTTKHLY 397
+ CLQ + L+ +GSS +RLWD ACL V C+R K +
Sbjct: 404 RGIACLQY-RDRLVVSGSS-DNTIRLWDIECGACLRVL----EGHEELVRCIRFDNKRIV 457
Query: 398 A-ALSYNLHVLDFQ 410
+ A + V D Q
Sbjct: 458 SGAYDGKIKVWDLQ 471
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 47.4 bits (111), Expect = 2e-05
Identities = 53/228 (23%), Positives = 94/228 (41%), Gaps = 40/228 (17%)
Query: 156 LGVFAGHDEDVCHFVLANSHIVSAGGDGKIGIHKIHSTFTVKYS----AHEQEVNCVDCK 211
L H+E V H +N +V+ D I + + S + H VN VD
Sbjct: 279 LNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFD 338
Query: 212 GGIIVSGSRDRTAKVWPLASGRLGQCLH-------TIQTEDRVWSIAISPLLSSFVTGTA 264
IVS S DRT KVW ++ + L+ +Q DR+ V+G++
Sbjct: 339 DKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRL-----------VVSGSS 387
Query: 265 CCGHFSPLRIWDLNSGQLMTHLGSDFPPGAGVLDVMYESPFTLLSCGYDTYVRYWDLRTS 324
+ +R+WD+ G + L V + +++ ++S YD ++ WDL+ +
Sbjct: 388 D----NTIRLWDIECGACLRVLEGHEEL---VRCIRFDNK-RIVSGAYDGKIKVWDLQAA 439
Query: 325 V-------RKCVMEWEEPHDSTLYCLQTDGNHLLATGSSYYGVVRLWD 365
+ C+ E H ++ LQ D +++ SS+ + +WD
Sbjct: 440 LDPRAPASTLCLRTLVE-HSGRVFRLQFDEFQIIS--SSHDDTILIWD 484
Score = 45.4 bits (106), Expect = 9e-05
Identities = 84/374 (22%), Positives = 139/374 (37%), Gaps = 39/374 (10%)
Query: 39 ICSYLDMRALGRLAQVCRWLRRFTSCDLLWRRIARASLNSGFTRLGTDLMTSVPVKERVK 98
I SYLD R+L VC+ +R S +LW+++ + + P+ + +
Sbjct: 101 ILSYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTD------------PLWKGLS 148
Query: 99 VSQNWRLGRCREGILLKWRCSQMPWMQLEDDSLYISQANFILAYQFRPDGASLNRRPLGV 158
+ W + L K R + P SLY I + N + +
Sbjct: 149 ERRGW------DQYLFKNRPTDGPPNSFYR-SLYPKIIQDIETIESNWRCGRHNLQRIQC 201
Query: 159 FAGHDEDVCHFVLANSHIVSAGGDGKIGIHKIHSTFTVKY-SAHEQEVNCVDCKGGIIVS 217
+ + + V + I+S D I I S +K + H V C+ +IV+
Sbjct: 202 RSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVT 261
Query: 218 GSRDRTAKVWPLASGRLGQCLHTIQTEDRVWSIAISPLLSSFVTGTACCGHFSPLRIWDL 277
GS D T +VW + +G + L I + V + S L C + +WD+
Sbjct: 262 GSSDSTVRVWDVNTGEVLNTL--IHHNEAVLHLRFSNGL------MVTCSKDRSIAVWDM 313
Query: 278 NSGQLMTHLGSDFPPGAGVLDVMYESPFTLLSCGYDTYVRYWDLRTSVRKCVMEWEEPHD 337
S +T A V V ++ + ++S D ++ W T + H
Sbjct: 314 ASATDITLRRVLVGHRAAVNVVDFDDKY-IVSASGDRTIKVWSTSTCE---FVRTLNGHK 369
Query: 338 STLYCLQTDGNHLLATGSSYYGVVRLWDRRQRACLHAFPLTSTPLSSPVYCLRLTTKHLY 397
+ CLQ + L+ +GSS +RLWD ACL V C+R K +
Sbjct: 370 RGIACLQY-RDRLVVSGSS-DNTIRLWDIECGACLRVL----EGHEELVRCIRFDNKRIV 423
Query: 398 A-ALSYNLHVLDFQ 410
+ A + V D Q
Sbjct: 424 SGAYDGKIKVWDLQ 437
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 47.4 bits (111), Expect = 2e-05
Identities = 53/228 (23%), Positives = 94/228 (41%), Gaps = 40/228 (17%)
Query: 156 LGVFAGHDEDVCHFVLANSHIVSAGGDGKIGIHKIHSTFTVKYS----AHEQEVNCVDCK 211
L H+E V H +N +V+ D I + + S + H VN VD
Sbjct: 300 LNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFD 359
Query: 212 GGIIVSGSRDRTAKVWPLASGRLGQCLH-------TIQTEDRVWSIAISPLLSSFVTGTA 264
IVS S DRT KVW ++ + L+ +Q DR+ V+G++
Sbjct: 360 DKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRL-----------VVSGSS 408
Query: 265 CCGHFSPLRIWDLNSGQLMTHLGSDFPPGAGVLDVMYESPFTLLSCGYDTYVRYWDLRTS 324
+ +R+WD+ G + L V + +++ ++S YD ++ WDL+ +
Sbjct: 409 D----NTIRLWDIECGACLRVLEGHEEL---VRCIRFDNK-RIVSGAYDGKIKVWDLQAA 460
Query: 325 V-------RKCVMEWEEPHDSTLYCLQTDGNHLLATGSSYYGVVRLWD 365
+ C+ E H ++ LQ D +++ SS+ + +WD
Sbjct: 461 LDPRAPASTLCLRTLVE-HSGRVFRLQFDEFQIIS--SSHDDTILIWD 505
Score = 45.4 bits (106), Expect = 9e-05
Identities = 84/374 (22%), Positives = 139/374 (37%), Gaps = 39/374 (10%)
Query: 39 ICSYLDMRALGRLAQVCRWLRRFTSCDLLWRRIARASLNSGFTRLGTDLMTSVPVKERVK 98
I SYLD R+L VC+ +R S +LW+++ + + P+ + +
Sbjct: 122 ILSYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTD------------PLWKGLS 169
Query: 99 VSQNWRLGRCREGILLKWRCSQMPWMQLEDDSLYISQANFILAYQFRPDGASLNRRPLGV 158
+ W + L K R + P SLY I + N + +
Sbjct: 170 ERRGW------DQYLFKNRPTDGPPNSFYR-SLYPKIIQDIETIESNWRCGRHNLQRIQC 222
Query: 159 FAGHDEDVCHFVLANSHIVSAGGDGKIGIHKIHSTFTVKY-SAHEQEVNCVDCKGGIIVS 217
+ + + V + I+S D I I S +K + H V C+ +IV+
Sbjct: 223 RSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVT 282
Query: 218 GSRDRTAKVWPLASGRLGQCLHTIQTEDRVWSIAISPLLSSFVTGTACCGHFSPLRIWDL 277
GS D T +VW + +G + L I + V + S L C + +WD+
Sbjct: 283 GSSDSTVRVWDVNTGEVLNTL--IHHNEAVLHLRFSNGL------MVTCSKDRSIAVWDM 334
Query: 278 NSGQLMTHLGSDFPPGAGVLDVMYESPFTLLSCGYDTYVRYWDLRTSVRKCVMEWEEPHD 337
S +T A V V ++ + ++S D ++ W T + H
Sbjct: 335 ASATDITLRRVLVGHRAAVNVVDFDDKY-IVSASGDRTIKVWSTSTCE---FVRTLNGHK 390
Query: 338 STLYCLQTDGNHLLATGSSYYGVVRLWDRRQRACLHAFPLTSTPLSSPVYCLRLTTKHLY 397
+ CLQ + L+ +GSS +RLWD ACL V C+R K +
Sbjct: 391 RGIACLQY-RDRLVVSGSS-DNTIRLWDIECGACLRVL----EGHEELVRCIRFDNKRIV 444
Query: 398 A-ALSYNLHVLDFQ 410
+ A + V D Q
Sbjct: 445 SGAYDGKIKVWDLQ 458
>gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens]
Length = 1298
Score = 46.6 bits (109), Expect = 4e-05
Identities = 49/191 (25%), Positives = 74/191 (38%), Gaps = 33/191 (17%)
Query: 167 CHFVLANSHIVSAGGDGKIGIHKIHST--FTVKYSAHEQEVNCVDCKGGIIVSGSRDRTA 224
C + V+ D + + H+ F VK+S + GI+ SGS D T
Sbjct: 517 CEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLRE---------GILCSGSDDGTV 567
Query: 225 KVWPLASGRLGQCL--HTIQTEDRVWSIAISPLLSSFVTGTACCGHFS-PLRIWDLNSGQ 281
++W L HT +W+ I LL S G + +++WD G
Sbjct: 568 RIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLIS--------GSWDYTIKVWDTREG- 618
Query: 282 LMTHLGSDFPPGAGV--LDVMYESPFTLLSCGYDTYVRYWDLRTSVRKCVM------EWE 333
T + + + GA V L PFT+ SC D+ VR W L V + WE
Sbjct: 619 --TCVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSLTALVTPVQINILADRSWE 676
Query: 334 EPHDSTLYCLQ 344
E +T Y ++
Sbjct: 677 EIIGNTDYAIE 687
>gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens]
Length = 1322
Score = 46.6 bits (109), Expect = 4e-05
Identities = 49/191 (25%), Positives = 74/191 (38%), Gaps = 33/191 (17%)
Query: 167 CHFVLANSHIVSAGGDGKIGIHKIHST--FTVKYSAHEQEVNCVDCKGGIIVSGSRDRTA 224
C + V+ D + + H+ F VK+S + GI+ SGS D T
Sbjct: 541 CEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLRE---------GILCSGSDDGTV 591
Query: 225 KVWPLASGRLGQCL--HTIQTEDRVWSIAISPLLSSFVTGTACCGHFS-PLRIWDLNSGQ 281
++W L HT +W+ I LL S G + +++WD G
Sbjct: 592 RIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLIS--------GSWDYTIKVWDTREG- 642
Query: 282 LMTHLGSDFPPGAGV--LDVMYESPFTLLSCGYDTYVRYWDLRTSVRKCVM------EWE 333
T + + + GA V L PFT+ SC D+ VR W L V + WE
Sbjct: 643 --TCVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSLTALVTPVQINILADRSWE 700
Query: 334 EPHDSTLYCLQ 344
E +T Y ++
Sbjct: 701 EIIGNTDYAIE 711
>gi|157266266 WD repeat domain 86 [Homo sapiens]
Length = 376
Score = 46.6 bits (109), Expect = 4e-05
Identities = 50/186 (26%), Positives = 83/186 (44%), Gaps = 28/186 (15%)
Query: 113 LLKWRCSQMPWMQLEDDSLYISQANFILAYQFRPDGASLNRRPLGVFAGHDEDVCHFVLA 172
LL+ S + + QLED++ + A+ + R D L + L V+ GH V ++A
Sbjct: 52 LLQGHESYVTFCQLEDEAAFTCSADCTIR---RWD--VLTGQCLQVYRGHTSIVNRILVA 106
Query: 173 NSHIVSAGGDGKIGIHKI-------------HSTFTVKYSAHEQ--EVNCVD--CKGGII 215
N+ + S+ D + + + T+ YSA C + GG++
Sbjct: 107 NNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLL 166
Query: 216 VSGSRDRTAKVWPLASGRLGQCLHTIQTEDRVWSIAISPLLSSFVTGTACCGHFSPLRIW 275
V+GS D TAKVW +ASG Q L T + + +P ++F T + +R W
Sbjct: 167 VTGSTDGTAKVWQVASGCCHQTLRG-HTGAVLCLVLDTPGHTAFTGSTD-----ATIRAW 220
Query: 276 DLNSGQ 281
D+ SG+
Sbjct: 221 DILSGE 226
Score = 40.4 bits (93), Expect = 0.003
Identities = 46/191 (24%), Positives = 73/191 (38%), Gaps = 42/191 (21%)
Query: 207 CVDCKGGI-----------IVSGSRDRTAKVWPLASGRLGQCLHTIQTEDRVWSIAISPL 255
C D +GGI +++GS D TA++W A GQC +Q + +
Sbjct: 11 CADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTAD---GQCCALLQGHESYVTFCQLED 67
Query: 256 LSSFVTGTACCGHFSPLRIWDLNSGQ-LMTHLGSDFPPGAGVLDVMYESPFTLLSCGYDT 314
++F C +R WD+ +GQ L + G +++ + + L S YD
Sbjct: 68 EAAFTCSADC-----TIRRWDVLTGQCLQVYRGH-----TSIVNRILVANNQLFSSSYDR 117
Query: 315 YVRYWDLRTSV--------RKCVM------EWEEPHDSTLYCLQTDGNHLLATGSSYYGV 360
R W + R CV+ W+ P ST + LL TGS+ G
Sbjct: 118 TARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLP--STPCAEEAAAGGLLVTGST-DGT 174
Query: 361 VRLWDRRQRAC 371
++W C
Sbjct: 175 AKVWQVASGCC 185
Score = 38.1 bits (87), Expect = 0.015
Identities = 36/128 (28%), Positives = 56/128 (43%), Gaps = 18/128 (14%)
Query: 198 YSAHEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRLGQCLHTIQTEDRVWSIAISPLLS 257
+ H V C++ ++ SGS DRT K W LA G+C+ T R S A+
Sbjct: 231 FREHRGSVICLELVNRLVYSGSADRTVKCW-LAD--TGECVRTFTAHRRNVS-ALKYHAG 286
Query: 258 SFVTGT--ACCGHFSPLRIWDLNSGQL-MTHLGSDFPPGAGVLDVMYESPFTLLSCGYDT 314
+ TG+ AC R +D SG+L G F +++ + L + +D
Sbjct: 287 TLFTGSGDACA------RAFDAQSGELRRVFRGHTF-----IINCIQVHGQVLYTASHDG 335
Query: 315 YVRYWDLR 322
+R WD+R
Sbjct: 336 ALRLWDVR 343
>gi|207029439 retinoblastoma binding protein 4 isoform c [Homo
sapiens]
Length = 390
Score = 45.8 bits (107), Expect = 7e-05
Identities = 50/192 (26%), Positives = 81/192 (42%), Gaps = 29/192 (15%)
Query: 158 VFAGHD---EDVCHFVLANSHIVSAGGDGKIGIHKIHSTFTVKYS----AHEQEVNCVDC 210
+F GH EDV +L S S D K+ I S T K S AH EVNC+
Sbjct: 187 IFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSF 246
Query: 211 KGG---IIVSGSRDRTAKVWPLASGRLGQCLHTIQT-EDRVWSIAISPLLSSFVTGTACC 266
I+ +GS D+T +W L + +L LH+ ++ +D ++ + SP + + A
Sbjct: 247 NPYSEFILATGSADKTVALWDLRNLKLK--LHSFESHKDEIFQVQWSPHNETIL---ASS 301
Query: 267 GHFSPLRIWDLN--SGQLMTHLGSDFPP---------GAGVLDVMY--ESPFTLLSCGYD 313
G L +WDL+ + D PP A + D + P+ + S D
Sbjct: 302 GTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSED 361
Query: 314 TYVRYWDLRTSV 325
++ W + ++
Sbjct: 362 NIMQVWQMAENI 373
>gi|207029415 retinoblastoma binding protein 4 isoform b [Homo
sapiens]
Length = 424
Score = 45.8 bits (107), Expect = 7e-05
Identities = 50/192 (26%), Positives = 81/192 (42%), Gaps = 29/192 (15%)
Query: 158 VFAGHD---EDVCHFVLANSHIVSAGGDGKIGIHKIHSTFTVKYS----AHEQEVNCVDC 210
+F GH EDV +L S S D K+ I S T K S AH EVNC+
Sbjct: 221 IFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSF 280
Query: 211 KGG---IIVSGSRDRTAKVWPLASGRLGQCLHTIQT-EDRVWSIAISPLLSSFVTGTACC 266
I+ +GS D+T +W L + +L LH+ ++ +D ++ + SP + + A
Sbjct: 281 NPYSEFILATGSADKTVALWDLRNLKLK--LHSFESHKDEIFQVQWSPHNETIL---ASS 335
Query: 267 GHFSPLRIWDLN--SGQLMTHLGSDFPP---------GAGVLDVMY--ESPFTLLSCGYD 313
G L +WDL+ + D PP A + D + P+ + S D
Sbjct: 336 GTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSED 395
Query: 314 TYVRYWDLRTSV 325
++ W + ++
Sbjct: 396 NIMQVWQMAENI 407
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.137 0.444
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,426,550
Number of Sequences: 37866
Number of extensions: 803125
Number of successful extensions: 3445
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 65
Number of HSP's successfully gapped in prelim test: 158
Number of HSP's that attempted gapping in prelim test: 2937
Number of HSP's gapped (non-prelim): 493
length of query: 412
length of database: 18,247,518
effective HSP length: 105
effective length of query: 307
effective length of database: 14,271,588
effective search space: 4381377516
effective search space used: 4381377516
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.