BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|224586823 coiled-coil domain containing 110 isoform b [Homo sapiens] (796 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|224586823 coiled-coil domain containing 110 isoform b [Homo s... 1557 0.0 gi|22749515 coiled-coil domain containing 110 isoform a [Homo sa... 1539 0.0 gi|55770834 centromere protein F [Homo sapiens] 108 2e-23 gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 95 2e-19 gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 95 3e-19 gi|71061468 centromere protein E [Homo sapiens] 94 5e-19 gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 93 8e-19 gi|41872583 Rho-associated, coiled-coil containing protein kinas... 92 2e-18 gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 89 2e-17 gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 88 4e-17 gi|38044112 restin isoform b [Homo sapiens] 83 9e-16 gi|4506751 restin isoform a [Homo sapiens] 83 9e-16 gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 82 1e-15 gi|58530840 desmoplakin isoform I [Homo sapiens] 82 2e-15 gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 81 3e-15 gi|217272802 hyaluronan-mediated motility receptor isoform a [Ho... 81 3e-15 gi|217272804 hyaluronan-mediated motility receptor isoform d [Ho... 81 4e-15 gi|109255234 centrosomal protein 290kDa [Homo sapiens] 80 6e-15 gi|31982906 cingulin-like 1 [Homo sapiens] 80 6e-15 gi|46049114 M-phase phosphoprotein 1 [Homo sapiens] 80 6e-15 gi|87298937 centrosomal protein 110kDa [Homo sapiens] 80 1e-14 gi|4885583 Rho-associated, coiled-coil containing protein kinase... 79 1e-14 gi|109134347 NY-REN-58 antigen [Homo sapiens] 77 5e-14 gi|109134355 NY-REN-58 antigen [Homo sapiens] 77 5e-14 gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 77 6e-14 gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 76 1e-13 gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 76 1e-13 gi|42794779 myosin 18A isoform b [Homo sapiens] 76 1e-13 gi|28416946 myosin 18A isoform a [Homo sapiens] 76 1e-13 gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 76 1e-13 >gi|224586823 coiled-coil domain containing 110 isoform b [Homo sapiens] Length = 796 Score = 1557 bits (4032), Expect = 0.0 Identities = 796/796 (100%), Positives = 796/796 (100%) Query: 1 MSPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQ 60 MSPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQ Sbjct: 1 MSPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQ 60 Query: 61 QQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQS 120 QQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQS Sbjct: 61 QQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQS 120 Query: 121 VNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADT 180 VNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADT Sbjct: 121 VNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADT 180 Query: 181 VILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHR 240 VILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHR Sbjct: 181 VILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHR 240 Query: 241 NGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFC 300 NGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFC Sbjct: 241 NGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFC 300 Query: 301 RKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKER 360 RKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKER Sbjct: 301 RKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKER 360 Query: 361 QPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKS 420 QPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKS Sbjct: 361 QPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKS 420 Query: 421 KMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNV 480 KMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNV Sbjct: 421 KMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNV 480 Query: 481 LQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTN 540 LQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTN Sbjct: 481 LQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTN 540 Query: 541 ILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETV 600 ILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETV Sbjct: 541 ILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETV 600 Query: 601 KDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEI 660 KDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEI Sbjct: 601 KDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEI 660 Query: 661 GKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENER 720 GKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENER Sbjct: 661 GKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENER 720 Query: 721 DTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRREKFHFDNYTHEDTSSPQSRPLAS 780 DTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRREKFHFDNYTHEDTSSPQSRPLAS Sbjct: 721 DTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRREKFHFDNYTHEDTSSPQSRPLAS 780 Query: 781 DLKGYFKVKDRTLKHH 796 DLKGYFKVKDRTLKHH Sbjct: 781 DLKGYFKVKDRTLKHH 796 >gi|22749515 coiled-coil domain containing 110 isoform a [Homo sapiens] Length = 833 Score = 1539 bits (3984), Expect = 0.0 Identities = 796/833 (95%), Positives = 796/833 (95%), Gaps = 37/833 (4%) Query: 1 MSPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQ 60 MSPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQ Sbjct: 1 MSPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQ 60 Query: 61 QQLESFQALRMQTLQNVSM-------------------------------------PTEN 83 QQLESFQALRMQTLQNVSM PTEN Sbjct: 61 QQLESFQALRMQTLQNVSMVQSEISEILNKSIIEVENPQFSSEKNLVFGTRIEKDLPTEN 120 Query: 84 QEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLS 143 QEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLS Sbjct: 121 QEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLS 180 Query: 144 SNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDD 203 SNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDD Sbjct: 181 SNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDD 240 Query: 204 ICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLD 263 ICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLD Sbjct: 241 ICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLD 300 Query: 264 GNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKE 323 GNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKE Sbjct: 301 GNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKE 360 Query: 324 IPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSV 383 IPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSV Sbjct: 361 IPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSV 420 Query: 384 TEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQL 443 TEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQL Sbjct: 421 TEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQL 480 Query: 444 KNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMM 503 KNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMM Sbjct: 481 KNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMM 540 Query: 504 EALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKS 563 EALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKS Sbjct: 541 EALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKS 600 Query: 564 SLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMER 623 SLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMER Sbjct: 601 SLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMER 660 Query: 624 EIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKE 683 EIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKE Sbjct: 661 EIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKE 720 Query: 684 ELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICN 743 ELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICN Sbjct: 721 ELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICN 780 Query: 744 QHNDPSKTTYISRREKFHFDNYTHEDTSSPQSRPLASDLKGYFKVKDRTLKHH 796 QHNDPSKTTYISRREKFHFDNYTHEDTSSPQSRPLASDLKGYFKVKDRTLKHH Sbjct: 781 QHNDPSKTTYISRREKFHFDNYTHEDTSSPQSRPLASDLKGYFKVKDRTLKHH 833 >gi|55770834 centromere protein F [Homo sapiens] Length = 3114 Score = 108 bits (270), Expect = 2e-23 Identities = 159/730 (21%), Positives = 322/730 (44%), Gaps = 100/730 (13%) Query: 60 QQQLESFQALRMQTLQNVSMP--TENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSL 117 ++QL + L+ + +N S+ EN E L M + + ++ L + K +++ + Sbjct: 2133 KKQLHIAEKLKERERENDSLKDKVENLERELQMSEEN--QELVILDAENSKAEVETLKTQ 2190 Query: 118 PQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQ 177 + + ++ D +TLR+ +NL+ I + S++ K ++F L Q Sbjct: 2191 IEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEK-----EQ 2245 Query: 178 ADTVILDKSKITVPFLKHGFCENLDDIC------HSIKQMKEELQKSHDGEVALTNELQT 231 A+ I ++SK V L++ E + + +K ++ L + E L N ++ Sbjct: 2246 AEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEK 2305 Query: 232 LQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDG---NLNEDIKSKRISELEALVKKLLPF 288 L+ + + K + + Q K + + L G NL +++ R ++ A ++ Sbjct: 2306 LRAR--LEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEA---- 2359 Query: 289 RETVSKFHVHFCRKCKKLSKSEMHRGK-------KNEKNN--KEIPITGKNITDLKFHSR 339 SK V K K ++ RG ++EK N E+ + I++L+ + Sbjct: 2360 --ENSKGEVETL-KAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINS 2416 Query: 340 VPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLK 399 L +Q K +MK+K + Q + NE+ + +++ E C AK Q L + ++ Sbjct: 2417 SFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVE 2476 Query: 400 ----ESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQS 455 E Q+ + + E ++ + L+S + LIQ+VE +++L+ EE S +++ Sbjct: 2477 CLELEKAQLLQGLDEAKNNYIVLQSSVN-------GLIQEVEDGKQKLEKKDEEISRLKN 2529 Query: 456 KLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHK 515 ++ E+ ++SK + ++G+++ +E+N++L ++ + + L+SK Sbjct: 2530 QIQDQEQ-----------LVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNAS 2578 Query: 516 TQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLE 575 Q + ++ + + E+E K + + ++ + K +L +E + + E Q E Sbjct: 2579 LQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEE 2638 Query: 576 IIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQI-------MERE---I 625 + EK RLA E + LL+ I++ KD+ E TL+ S + + +E+E Sbjct: 2639 L--SGEKNRLA-GELQLLLEEIKSSKDQL--KELTLENSELKKSLDCMHKDQVEKEGKVR 2693 Query: 626 ENIQTYQSTAEEN-------FLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVME----- 673 E I YQ E L K + E Y+ L+ +EC K+ ++ Sbjct: 2694 EEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTS-KEECLSSQKLEIDLLKSS 2752 Query: 674 -------TKTDNQILKEELKKHSQENIKFENSISRLTED-----KILLENYVRSIENERD 721 K QIL EELKK +N+K+ N + + E K+L+++ + +E E++ Sbjct: 2753 KEELNNSLKATTQIL-EELKKTKMDNLKYVNQLKKENERAQGKMKLLIKS-CKQLEEEKE 2810 Query: 722 TLEFEMRHLQ 731 L+ E+ LQ Sbjct: 2811 ILQKELSQLQ 2820 Score = 80.1 bits (196), Expect = 7e-15 Identities = 146/706 (20%), Positives = 299/706 (42%), Gaps = 108/706 (15%) Query: 44 AESEN---QIQP-QSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDS 99 +E EN QIQ Q L L + L SF++L + Q E + + M ++ Sbjct: 2210 SEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQ----L 2265 Query: 100 KTLHSVEEKLSGDS--VNSLPQSVNVPSQI-----HSEDTLTLRTSTDNLSSNIIIHPSE 152 K L+ L GD + + QS++ P + +S + L R D ++ + Sbjct: 2266 KELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLK 2325 Query: 153 NS----DILKN-YNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHS 207 S D+LK N R L A N A + + SK V LK ++ + S Sbjct: 2326 ESEHHADLLKGRVENLERELEIARTNQEHAA--LEAENSKGEVETLK----AKIEGMTQS 2379 Query: 208 IKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLN 267 ++ ++ ++ + LTNELQ Q ++ I+ N ++E+ + Sbjct: 2380 LRGLELDVVTIRSEKENLTNELQKEQERIS-------ELEIINSSFENILQEKEQE---K 2429 Query: 268 EDIKSKRISELEALVKKLLPFRETVSKFH--VHFCR----------KCKKLSKSEMHRGK 315 +K K + +E L +L E V+ H C+ +C +L K+++ +G Sbjct: 2430 VQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGL 2489 Query: 316 KNEKNNKEIPITGKN--ITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQ--GSII 371 KNN + + N I +++ + + + K++++D+E+ + Q G Sbjct: 2490 DEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQ 2549 Query: 372 SENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQS 431 E+ ++ ++T + KIQ LQ+ ++ +Q + L+S NL+++++ S Sbjct: 2550 LWKEQNLELRNLTVELEQKIQVLQS---KNASLQDTLEVLQSSYKNLENELELTKMDKMS 2606 Query: 432 LIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEK 491 ++KV K E + + KT E +E E ++ + +L + K+ +++ Sbjct: 2607 FVEKVN---KMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQ 2663 Query: 492 NIQLSLEKQQMMEALDQLKS----KEHKTQSDMA---------------IVNNENNRMSI 532 +L+LE ++ ++LD + KE K + ++A ++ + N + + Sbjct: 2664 LKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEV 2723 Query: 533 EME--------------AMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLE--- 575 E++ + K I L++ KE L LK + + ELK+++++ Sbjct: 2724 EIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNS----LKATTQILEELKKTKMDNLK 2779 Query: 576 -IIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQ------IMEREIENI 628 + QLK++ A+ + + L++ + +++EK L+ L + AA++ +M+ +++ + Sbjct: 2780 YVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDEL 2839 Query: 629 QTYQSTAEENFLQEIKNAKSEASIYKNSL---SEIGKECEMLSKMV 671 T +E ++ K A Y + L ++ K EML V Sbjct: 2840 TTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQV 2885 Score = 75.1 bits (183), Expect = 2e-13 Identities = 135/607 (22%), Positives = 250/607 (41%), Gaps = 107/607 (17%) Query: 202 DDICHSIKQMKEE--LQKSHDGEVA-----LTNELQTLQTDPDVHRNGKYDMSPIHQDKM 254 +++ S+++MK+E L KSH + A L EL+ ++ + +N +M + + Sbjct: 475 NELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQE 534 Query: 255 NFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRG 314 +++ L +N+ S + +L+ V L R+ L K E H Sbjct: 535 TMLRD--LQEKINQQENSLTLEKLKLAVADLEKQRDCSQDL----------LKKREHHIE 582 Query: 315 KKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISEN 374 + N+K +K + + LS L+ K E ++ + + L SEN Sbjct: 583 QLNDKLSKT--------------EKESKALLSALELKKKEYEELKEEKTLFSCWK--SEN 626 Query: 375 EKT-SKVNSVTEQCVAKIQYLQNYLK----ESVQIQKKVMELESENLNLKSKMKPLIFTT 429 EK +++ S E +KI +L+ LK +S + ++V LE + NL +++ L Sbjct: 627 EKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVL 686 Query: 430 QSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLE 489 S +VET +K K E ++ KE + + K + L GQ + LE Sbjct: 687 DSKSVEVET----------QKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLE 736 Query: 490 EKNIQLS---LEKQQMMEAL--------DQLKSKEHKTQSDMAIVNNENNRMSIEMEAMK 538 K LS ++K + + L D LKSK D ++V NE+++ S Sbjct: 737 HKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSK------DASLVTNEDHQRS------- 783 Query: 539 TNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIE 598 LL D++ + ++ E+ S+ +E E +LE Q + + + ++L +E Sbjct: 784 ---LLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLE 840 Query: 599 TVKDEKLNLETTLQESTAAR-QIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSL 657 + K +L+ +E + +I E ++ Q +QS E Q I + + S ++N + Sbjct: 841 SQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETS-QRISKLQEDTSAHQNVV 899 Query: 658 SEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIE 717 +E E K + Q+L ++++ E I L + LLE+ ++ ++ Sbjct: 900 AETLSALENKEKEL-------QLLNDKVETEQAE-------IQELKKSNHLLEDSLKELQ 945 Query: 718 NERDTLEFEMRHL-------QREYLSLSD-----KICNQHNDPSKTTYISRREKFHFDNY 765 +TL E + + +RE L+ K N + K I + E F NY Sbjct: 946 LLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSES--FANY 1003 Query: 766 THEDTSS 772 E S Sbjct: 1004 IDEREKS 1010 Score = 74.7 bits (182), Expect = 3e-13 Identities = 93/455 (20%), Positives = 192/455 (42%), Gaps = 53/455 (11%) Query: 348 LDQTK---HEMKDKERQPFLVKQGSIISENEKTSKVNSVTE----------QCVAKIQYL 394 LDQ K E+++K + L QG E E +VN E + + K + L Sbjct: 280 LDQLKAQNQELRNKINELELRLQGH---EKEMKGQVNKFQELQLQLEKAKVELIEKEKVL 336 Query: 395 QNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKST-I 453 E V+ + + ++ L+ K+K L Q E+ L+ ++EK Sbjct: 337 NKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEF 396 Query: 454 QSKLSKTEE----YSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQL 509 Q +LS+ + +EC++ ++ + + + L+ + +L+ KQQ+ L++ Sbjct: 397 QEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEF 456 Query: 510 KSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNEL 569 K K + + + N + ME MK L++ E ++ L E ++ L Sbjct: 457 KQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCL 516 Query: 570 KESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQ 629 +SQ E+ + T QET+L+ ++ EK+N QE++ + ++ + +++ Sbjct: 517 NQSQ----NFAEEMKAKNTSQETMLRDLQ----EKIN----QQENSLTLEKLKLAVADLE 564 Query: 630 TYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHS 689 + +++ +K + + LS+ KE + L + K + + LKEE S Sbjct: 565 KQRDCSQD----LLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFS 620 Query: 690 QENIKFENSISRLTEDKILLENYVRSIENERDTLEFE-------MRHLQREYLSLSDKIC 742 + E ++++ +K L++ + +E T + + +R L+ + +LS +I Sbjct: 621 CWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIR 680 Query: 743 NQHN---------DPSKTTYISRREKFHFDNYTHE 768 N HN + K Y+ ++K F + H+ Sbjct: 681 NLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQ 715 Score = 73.6 bits (179), Expect = 7e-13 Identities = 92/411 (22%), Positives = 183/411 (44%), Gaps = 53/411 (12%) Query: 353 HEMKDKERQPFLVKQGSIISE-NEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMEL 411 H ++D++R K S+++E E SK++ Q + KI+ ++++K V EL Sbjct: 1788 HVIEDRDR-----KVESLLNEMKELDSKLHLQEVQLMTKIE-------ACIELEKIVGEL 1835 Query: 412 ESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNL-----VEEKSTIQSKLSKTEEYSKE 466 + EN +L K++ Q L+Q+VET E +L + I ++K + KE Sbjct: 1836 KKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKE 1895 Query: 467 CLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMM-EALDQLKSKEHK------TQSD 519 F + ++ + ++ + ++E + + L + + + E L K E+K + + Sbjct: 1896 ---RFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEE 1952 Query: 520 MAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQL 579 +++V +E N++ E++ M + E +++KT +L +S L IQ+ Sbjct: 1953 LSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSEC--------LHCIQV 2004 Query: 580 KEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENF 639 E E KTE LLQ + + E L +T LQE Q +E++ + + + E Sbjct: 2005 AEAEVKEKTE---LLQTLSSDVSELLKDKTHLQEKL---QSLEKDSQALSLTKCELENQI 2058 Query: 640 LQEIKNAK---SEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFE 696 Q K + E+ + LSE E +SK + + L +E + Sbjct: 2059 AQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLR 2118 Query: 697 NSISRL-------TEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDK 740 I +L + ++ + ++ E E D+L+ ++ +L+RE L +S++ Sbjct: 2119 RGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERE-LQMSEE 2168 Score = 73.2 bits (178), Expect = 9e-13 Identities = 161/788 (20%), Positives = 320/788 (40%), Gaps = 156/788 (19%) Query: 51 QPQSALKVLQQQL----ESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVE 106 Q ++ L+ +Q+L ++FQA +++ + E ++EN ++ KSH + ++ + +E Sbjct: 448 QLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKEN-NLLKSHSEQKAREVCHLE 506 Query: 107 EKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRF 166 +L ++ Q +N SQ +E+ TS + + ++ Sbjct: 507 AELK-----NIKQCLN-QSQNFAEEMKAKNTSQETMLRDL-------------------- 540 Query: 167 LPTAPPNVMSQADTVILDKSKITVPFL-KHGFCEN--LDDICHSIKQMKEELQKSHDGEV 223 + Q +++ L+K K+ V L K C L H I+Q+ ++L K+ Sbjct: 541 ----QEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESK 596 Query: 224 ALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFI-----KEENLDGNLNE---DIKSKRI 275 AL + L+ + + + + K S + + ++ENL +N +K+++I Sbjct: 597 ALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQI 656 Query: 276 S--ELEALVKKLLPFRETVS----KFHVHFCRKC-----KKLSKSEMHRGKK--NEKNNK 322 E V+ L RE +S H K +KL+ E+ + + ++K+ K Sbjct: 657 KSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQK 716 Query: 323 EIP--------ITGKNITDLKFHSRVPRYTLSFLD---QTKHEMKDKERQPFLVKQGSII 371 EI +TG+ + DL+ ++ + D Q H + R K S++ Sbjct: 717 EIENMCLKTSQLTGQ-VEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLV 775 Query: 372 SENEKTSKVNSVTEQCVAKIQYLQNYLKE--SVQIQKKVMELESE-----NLNLKSKMKP 424 + NE + +Q A N + E S+ ++ LE++ + L++++ Sbjct: 776 T-NEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDS 834 Query: 425 LIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISK------- 477 L F+ +S Q +KQ + LV+ K I+ L K E+ + + E + ISK Sbjct: 835 LEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSA 894 Query: 478 -YNVLQGQNKTLE--EKNIQLSLEKQQMMEA-LDQLKSKEHKTQSDMAIVNNENNRMSIE 533 NV+ LE EK +QL +K + +A + +LK H + + + + +S+E Sbjct: 895 HQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLE 954 Query: 534 MEAMKTNILLIQDEKE--------------MLEKKTHQLLKEKSSLGNELKESQLEIIQL 579 + M + I L + E E L ++ L+++ S N + E + I +L Sbjct: 955 KKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISEL 1014 Query: 580 KEKERLAK-----------TEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENI 628 ++ + K E L Q + +++ LE L E T+ + + E+E + Sbjct: 1015 SDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQL 1074 Query: 629 QTYQSTAEENFLQEI-----------------------------KNAKSEASIYKNSLSE 659 + + + FL ++ N+KSEA K + Sbjct: 1075 KEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMT 1134 Query: 660 IGKECEMLSKMVMETKTDNQILKEELK-KHSQENIKFENSISRLTEDKILLENYVRSIEN 718 + +E + K V + +N+ L + +K KH +N++ E + N V+ E+ Sbjct: 1135 LKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEP-----------IRNSVKERES 1183 Query: 719 ERDTLEFE 726 ER+ F+ Sbjct: 1184 ERNQCNFK 1191 Score = 71.6 bits (174), Expect = 3e-12 Identities = 134/745 (17%), Positives = 291/745 (39%), Gaps = 81/745 (10%) Query: 35 CSDTEYGCIAESENQI---------------QPQSALKVLQQQLESFQALRMQTLQNVSM 79 C + E + NQ+ Q +K Q+LES Q+ + +Q Sbjct: 1948 CLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEA 2007 Query: 80 PTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTST 139 + + E L S E K ++EKL QS+ SQ S L Sbjct: 2008 EVKEKTELLQTLSSDVSELLKDKTHLQEKL---------QSLEKDSQALSLTKCELENQI 2058 Query: 140 DNLSSN--IIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGF 197 L+ +++ SE+ + +++ + NV + +++K + + Sbjct: 2059 AQLNKEKELLVKESESLQARLSESDYEKL------NVSKALEAALVEKGEFALRLSSTQ- 2111 Query: 198 CENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFI 257 E + + I++++ ++ ++ + +L+ + + D ++ Sbjct: 2112 -EEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKD---------------- 2154 Query: 258 KEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKN 317 K ENL+ L +++ + L+A K ET+ R K + + Sbjct: 2155 KVENLERELQMSEENQELVILDAENSKAEV--ETLKTQIEEMARSLKVFELDLVTLRSEK 2212 Query: 318 EKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKT 377 E K+I +++L + L +Q + ++K++ + + Q + NE Sbjct: 2213 ENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAV 2272 Query: 378 SKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMEL-------ESENLNLKSKMKPLIFTTQ 430 + + E A Q L ++E Q++ + +L E + L + ++K Sbjct: 2273 AALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHAD 2332 Query: 431 SLIQKVETYEKQLK--NLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTL 488 L +VE E++L+ +E + ++++ SK E E LK KI L+G L Sbjct: 2333 LLKGRVENLERELEIARTNQEHAALEAENSKGEV---ETLKA--KIEGMTQSLRG----L 2383 Query: 489 EEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNIL-LIQDE 547 E + + EK+ + L KE + S++ I+N+ + E E K + Sbjct: 2384 ELDVVTIRSEKENLTNELQ----KEQERISELEIINSSFENILQEKEQEKVQMKEKSSTA 2439 Query: 548 KEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNL 607 EML+ + +L + ++L N+ + + + L + + E+ LLQ ++ K+ + L Sbjct: 2440 MEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVL 2499 Query: 608 ETT----LQESTAARQIMEREIENIQTYQSTAE--ENFLQEIKNAKSEASIYKNSLSEIG 661 +++ +QE +Q +E++ E I ++ + E + ++ + E ++K E+ Sbjct: 2500 QSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELR 2559 Query: 662 KECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERD 721 L + + ++ N L++ L+ EN + DK+ V + + Sbjct: 2560 NLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKET 2619 Query: 722 TLEFEMRHLQREYLSLSDKICNQHN 746 L+ EM + ++ L +++ + N Sbjct: 2620 ELQREMHEMAQKTAELQEELSGEKN 2644 Score = 63.9 bits (154), Expect = 6e-10 Identities = 168/841 (19%), Positives = 324/841 (38%), Gaps = 138/841 (16%) Query: 17 LLSASKILNSSEGVKESGC-SDTEYGCIAESENQIQPQSALKVLQQQLESFQALRMQTLQ 75 LL+ KILN G+ D G E N+ P S + + S++ L + + Sbjct: 1342 LLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPL--DESNSYEHLTLSDKE 1399 Query: 76 NVSMPTENQEENLSMEKSH------HFEDSKTLHSVEEKLSGDSVNSLPQSVNVPS---Q 126 E QE+ LS++ H H + S + ++ + +L S N+ + Sbjct: 1400 VQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGD 1459 Query: 127 IHSEDTLTLRTS-TDNLSSNIIIHPSENSDILKNYNNFYRFL--PTAPPNVMSQADTVI- 182 + E L L +LSS+ + S S + ++FYR L T +++S + + Sbjct: 1460 LVKEMQLGLEEGLVPSLSSSCVPDSSSLSSL--GDSSFYRALLEQTGDMSLLSNLEGAVS 1517 Query: 183 -------------LDKSKIT---VPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALT 226 L + +T P E L+ +C +Q E+L++ + + + Sbjct: 1518 ANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMK 1577 Query: 227 N-ELQTLQT-------DPDVHRNGKYDMSPIHQDKMNFI-----------KEENLDGNLN 267 N E+Q L+ + D R + Q K+ + K++ +L Sbjct: 1578 NKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLE 1637 Query: 268 EDIKSKRISELEALVKKLLPF---------RETVSKFHVHFCRKCKKLSKSEMHRGKKNE 318 ++ ++ L+ + LL E+ H ++ K ++H+ + Sbjct: 1638 LEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKD 1697 Query: 319 KNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTS 378 +++ + + IT+ + T +E +++ QGS +E S Sbjct: 1698 AQ-QDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKT-----QGS----SECIS 1747 Query: 379 KVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNL-------KSKMKPLIFTTQS 431 +++ + + +L N ++ +Q +V E +ENL L K++ L+ + Sbjct: 1748 ELSFSGPNALVPMDFLGNQ-EDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKE 1806 Query: 432 LIQKVETYEKQLKNLVE---EKSTIQSKLSKTEEYSKECLKEF----KKIISKYNVLQGQ 484 L K+ E QL +E E I +L K E L+ F ++++ + +G Sbjct: 1807 LDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGL 1866 Query: 485 NKTLEEKNIQLSLEK--QQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAM--KTN 540 N LE + S E + + D K + +++++ + +E + SIE EA+ + + Sbjct: 1867 NSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSE--KASIEHEALYLEAD 1924 Query: 541 ILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETV 600 + ++Q EK LEK K L EL E QL+ + + L Q+ E + Sbjct: 1925 LEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKM 1984 Query: 601 KDEKLNLETTLQESTAARQIMEREI----ENIQTYQSTAEE---------NFLQEIKNAK 647 K++ LE+ E Q+ E E+ E +QT S E LQ ++ Sbjct: 1985 KEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDS 2044 Query: 648 SEASIYK----NSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSIS--- 700 S+ K N ++++ KE E+L K +++ L+ L + E + ++ Sbjct: 2045 QALSLTKCELENQIAQLNKEKELLVK-------ESESLQARLSESDYEKLNVSKALEAAL 2097 Query: 701 --------RLTEDKILLENYVRSIENERDTLEFE----------MRHLQREYLSLSDKIC 742 RL+ + + R IE R +E + ++ +RE SL DK+ Sbjct: 2098 VEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVE 2157 Query: 743 N 743 N Sbjct: 2158 N 2158 Score = 37.7 bits (86), Expect = 0.042 Identities = 144/793 (18%), Positives = 316/793 (39%), Gaps = 113/793 (14%) Query: 59 LQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLP 118 L+ Q + L+ Q + V + E +E + E+ H ++T + + S + Sbjct: 839 LESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNV 898 Query: 119 QSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQA 178 + + + + E L L L+ + +E ++ K+ + L + + + Sbjct: 899 VAETLSALENKEKELQL------LNDKVETEQAEIQELKKSNH----LLEDSLKELQLLS 948 Query: 179 DTVILDKSKIT-VPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPD 237 +T+ L+K +++ + L E L ++K++ L + ++ L + ++ D Sbjct: 949 ETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQE---KMNLIQKSESFANYID 1005 Query: 238 VHRNGKYDMSPIH-QDKMNFIKEENLDGNLNEDIKSK------RISELEALVKK------ 284 ++S + Q+K+ ++ GN ED+ K + S+LE L+ + Sbjct: 1006 EREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCE 1065 Query: 285 -----LLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSR 339 L +E +K H F K + + + E + + +TD + +S+ Sbjct: 1066 NRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALR---SEMTDNQNNSK 1122 Query: 340 VPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCV-AKIQYLQNYL 398 L T E ++K ++ + ++ ENE+ KV +C + + ++N + Sbjct: 1123 SEAGGLKQEIMTLKEEQNKMQK----EVNDLLQENEQLMKVMKTKHECQNLESEPIRNSV 1178 Query: 399 KESVQIQ-----KKVMELESENLNLKSKMKPLIFTTQSLIQK---VETYEKQLKNLVEEK 450 KE + K M+LE + ++L S L+ L K ++ EK+ + L E Sbjct: 1179 KERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHEL 1238 Query: 451 STIQSKLS-------KTEEYS--KECL--KEFKKIISKYNVLQGQNKTLE-EKNIQLSLE 498 TI+ L +++E S K+C E K I + + QN + ++Q ++ Sbjct: 1239 QTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMN 1298 Query: 499 KQQMMEALDQ-LKSKEHKTQSDMAIVNNE----NNRMSIEMEAMKTNILLIQDEKEMLE- 552 K +E + + L++++++ +++ +E +M+ E+ + + ++ D+ +L Sbjct: 1299 KLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHG 1358 Query: 553 ---------------KKTHQL----LKEKSS---LGNELKESQLEIIQLKEKERLAKTEQ 590 + H + L E +S L KE Q+ +L+EK ++E Sbjct: 1359 ELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEH 1418 Query: 591 ETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQ-----TYQSTAEENFLQEIK- 644 + L + + L+T + A ++ + N Q Q EE + + Sbjct: 1419 KILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSS 1478 Query: 645 ---------NAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEEL--KKHSQENI 693 ++ ++S Y+ L + G + +LS + NQ +E+ +EN+ Sbjct: 1479 SCVPDSSSLSSLGDSSFYRALLEQTG-DMSLLSNLEGAVSA-NQCSVDEVFCSSLQEENL 1536 Query: 694 KFENSISR----LTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICN--QHND 747 + + S + E + L E Y +S+E + +E + +E L + + Q D Sbjct: 1537 TRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELD 1596 Query: 748 PSKTTYISRREKF 760 + Y+S E++ Sbjct: 1597 CLRKQYLSENEQW 1609 Score = 36.6 bits (83), Expect = 0.094 Identities = 57/307 (18%), Positives = 123/307 (40%), Gaps = 22/307 (7%) Query: 433 IQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKN 492 +QK++ E QL L +EK Q +L E + K+ +K+ +N+ E N Sbjct: 17 LQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQ---KQKQKV---------ENEKTEGTN 64 Query: 493 IQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDE----K 548 L E Q++ME + L+ + K ++ + ++ N ++ + K I ++ E K Sbjct: 65 --LKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCK 122 Query: 549 EMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLE 608 LE+ SL ++ L + + ++ E L + +E+ LE Sbjct: 123 SELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLE 182 Query: 609 TTLQ--ESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEM 666 ++ ++ A Q + + N + + + + K+ + + NS + Sbjct: 183 AEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFS 242 Query: 667 LSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFE 726 S E + ++ K + F+NS S D++ +N + + N+ + LE Sbjct: 243 ASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQN--QELRNKINELELR 300 Query: 727 MRHLQRE 733 ++ ++E Sbjct: 301 LQGHEKE 307 Score = 34.7 bits (78), Expect = 0.36 Identities = 53/228 (23%), Positives = 87/228 (38%), Gaps = 25/228 (10%) Query: 551 LEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETT 610 LE + +L KEK +L + + + K+K KTE L + + + + +LE T Sbjct: 23 LEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEKT 82 Query: 611 LQESTAARQIMEREIENIQTYQSTAE----ENFLQEIKNAKSEASIYKNSLSEIG---KE 663 Q+ + Q+ E ++ N Q Q + E QE+K KSE + + Sbjct: 83 KQKISHELQVKESQV-NFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNP 141 Query: 664 CEMLSKMVMETKTDNQI--------LKEELKKHSQENIKFENSISRLTEDKILLENYVRS 715 C K+ T +Q LKE+ K +E + E + L + K + ++ Sbjct: 142 CNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKAL-QAKKASQTLPQA 200 Query: 716 IENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRREKFHFD 763 N RD + R S S Q PS + S+R D Sbjct: 201 TMNHRD--------IARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRD 240 >gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo sapiens] Length = 1870 Score = 95.1 bits (235), Expect = 2e-19 Identities = 173/821 (21%), Positives = 336/821 (40%), Gaps = 104/821 (12%) Query: 45 ESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKS-HHFEDSKTLH 103 E EN+I +S +K +L + + Q + + E E +E HH E L Sbjct: 586 EKENKILHES-IKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELL 644 Query: 104 S---VEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRT--STDNLSSNIIIHPSENSDILK 158 K++ + + +L Q S++ E+ +T S NL+ + ENS + + Sbjct: 645 QKKITNLKITCEKIEALEQE---NSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDE 701 Query: 159 NYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKS 218 R + + M A + +K + K + L+ + S K+ E L+ S Sbjct: 702 ENLELRRNVESLKCASMKMAQLQLENKE---LESEKEQLKKGLELLKASFKKT-ERLEVS 757 Query: 219 HDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNF-IKEENLDGNLNE-DIKSKRIS 276 + G L E Q LQ + N + + + + ++ + L NL E I SKR+ Sbjct: 758 YQG---LDIENQRLQKTLE---NSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLE 811 Query: 277 ELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKF 336 +LE K L + K ++ K+L + + E+NN +I K L Sbjct: 812 QLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSK 871 Query: 337 HSRVPRYTLSFLDQTKHEMKDKERQP------FLVKQGSIISENEKTSKVNSVTEQCVAK 390 + + + L + + E K+ ++ + + ++SE KT ++N+ E+ + Sbjct: 872 EIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHE 931 Query: 391 IQY-------------------------LQNYLKESVQI-QKKVMELES---ENLNLKSK 421 ++ L++ LK+S++I ++K+ LE+ E+ N + Sbjct: 932 LEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQ 991 Query: 422 MKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVL 481 ++ + T + + ++ + + + +V+ I + +K E S+E +E K+ + + Sbjct: 992 LRQELKTVKKNYEALKQRQDE-ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEV 1050 Query: 482 QGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNI 541 + N TL+ + L + +Q+ + L+++ Q + +N + + ++ Sbjct: 1051 ERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVEN 1110 Query: 542 LLIQDEKEMLEKKTHQLLKEKSSLGNE----LKESQ----LEIIQLKEKERL------AK 587 + + L + QLL ++SSL NE +KE + L +K+ E+L Sbjct: 1111 STLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQA 1170 Query: 588 TEQETLLQIIETVKDEKLNLETTLQE-STAARQIMER--EIENIQTYQSTAEENFLQEIK 644 +E E+L+ T+K NLE ++ Q++++ ++E+++ +E L E K Sbjct: 1171 SEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENK 1230 Query: 645 NAKSEASIYKNSLSEIGKECEMLSKMVMET---KTDNQILKEELKKHSQENIKFENSISR 701 N ++ A+ YK E + S+++ ET +TD++ LK L E + E S+ Sbjct: 1231 NHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSK 1290 Query: 702 LTED-------KILLENYVRSIENERDTLEFEMRHL--QREYLSLSDKICNQHNDPSK-- 750 L E L N + + LE E RHL Q + L L ++ + N SK Sbjct: 1291 LKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDL 1350 Query: 751 -----TTYISR-------REKFH---FDNYTHEDTSSPQSR 776 YI + +EK D Y D S P+ R Sbjct: 1351 FHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRR 1391 Score = 77.4 bits (189), Expect = 5e-14 Identities = 78/367 (21%), Positives = 167/367 (45%), Gaps = 39/367 (10%) Query: 394 LQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTI 453 L++ L+ + K+ ELE ENL LK+K+ + + + K+++ L+EE T+ Sbjct: 363 LEDQLEGTRARSDKLHELEKENLQLKAKL-------HDMEMERDMDRKKIEELMEENMTL 415 Query: 454 QSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTL--------EEKNIQLSLEKQQMMEA 505 + ++ + S E ++I + + K+L + ++L +E Q + + Sbjct: 416 EMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKT 475 Query: 506 LDQLKSKEHKTQ---SDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEK 562 +++L++ + S + + EN R+S ++E ++ I+ + + + + L+KEK Sbjct: 476 VEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEK 535 Query: 563 SSLGNELKESQLEIIQLKEKERLAKTEQET--LLQIIETVKD-EKLNLETTLQESTAARQ 619 + L E +E ++ + ++ EQE L Q + +++ +++ E +++ + Sbjct: 536 AQL-----EKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENK 590 Query: 620 IMEREIENIQTYQSTAE------ENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVME 673 I+ I+ + S E + L+ K A +N L + KE E+L K + Sbjct: 591 ILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKI-- 648 Query: 674 TKTDNQILKEELKKHSQENIKFENSISRLTEDKILLEN---YVRSIENERDTLEFEMRHL 730 T+ +I E+++ QEN + E +L + +N + S+E E L+ E L Sbjct: 649 --TNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLEL 706 Query: 731 QREYLSL 737 +R SL Sbjct: 707 RRNVESL 713 Score = 72.4 bits (176), Expect = 2e-12 Identities = 149/691 (21%), Positives = 284/691 (41%), Gaps = 145/691 (20%) Query: 199 ENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIK 258 E L DI K EEL++ D +V L E +T+ D + + + DK++ ++ Sbjct: 334 ERLHDI-EFYKARVEELKE--DNQVLL--ETKTMLED-------QLEGTRARSDKLHELE 381 Query: 259 EENL-------DGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSK-SE 310 +ENL D + D+ K+I EL L ++ +H + +++S+ SE Sbjct: 382 KENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSE 441 Query: 311 MHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSI 370 + + ++ +T + L+ ++ L +T E++ Sbjct: 442 LSEAPQKSLGHEVNELTSSRLLKLEMENQS-------LTKTVEELR-------------- 480 Query: 371 ISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENL-------NLKSKMK 423 + V+SV E +KI ++ KE+ ++ KKV LE+E + N ++ K Sbjct: 481 -------TTVDSV-EGNASKILKME---KENQRLSKKVEILENEIVQEKQSLQNCQNLSK 529 Query: 424 PLIFTTQSLIQKVETY----EKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYN 479 L+ L + +ET E+Q+K L +E + +S + S+ + K I K N Sbjct: 530 DLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKEN 589 Query: 480 -VLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMK 538 +L K K ++ EK+Q+ + L+ K K + + + NE + + E E ++ Sbjct: 590 KILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEE----LENELHHLEKENELLQ 645 Query: 539 ---TNILLIQDEKEMLE-------------KKT-----------HQLLKEKSSLGNE--- 568 TN+ + ++ E LE KKT L KE S L E Sbjct: 646 KKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLE 705 Query: 569 -------LKESQLEIIQLKEKERLAKTEQETLLQIIETVKD-----------------EK 604 LK + +++ QL+ + + ++E+E L + +E +K E Sbjct: 706 LRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIEN 765 Query: 605 LNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKEC 664 L+ TL+ S Q +E E+++++ T ++N L+E+K + + + +E Sbjct: 766 QRLQKTLENSNKKIQQLESELQDLEMENQTLQKN-LEELKISSKRLEQLEKENKSLEQET 824 Query: 665 EMLSKMVMETKTDNQILKE--ELKKHSQE--NIKFEN----SISRLTEDKILLENYVRSI 716 L K + + +N+ L++ E+K + E N+K N + + E I E+ VR Sbjct: 825 SQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLK 884 Query: 717 ENERDTLEFEMR---------HLQREYLSLSDKICNQHNDPSKTTYISRREKFHFDNYTH 767 E E++ E R L+ + +S K +ND K T+ + + + H Sbjct: 885 ELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLH 944 Query: 768 EDTSSPQ-----SRPLASDLKGYFKVKDRTL 793 ++ S+ L S LK ++K+ + Sbjct: 945 DEQSTDDRYKLLESKLESTLKKSLEIKEEKI 975 Score = 70.1 bits (170), Expect = 8e-12 Identities = 95/412 (23%), Positives = 185/412 (44%), Gaps = 65/412 (15%) Query: 378 SKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVE 437 +K+ + ++ K + L + +E Q++ ++ L+ EN+NL S + L + Sbjct: 258 AKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDEL-DALR 316 Query: 438 TYEKQLKNLVEEKSTIQSKLSKTEEYSK--ECLKEFKKIISKYNVLQGQNKTLEEKNIQL 495 ++ L E S + +L E Y E LKE +++ + KT+ E ++ Sbjct: 317 EKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLL-------ETKTMLEDQLEG 369 Query: 496 SLEKQQMMEALD----QLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEML 551 + + + L+ QLK+K H + + + +R IE E M+ N+ L +K+ + Sbjct: 370 TRARSDKLHELEKENLQLKAKLHDME-----MERDMDRKKIE-ELMEENMTLEMAQKQSM 423 Query: 552 EKKTH------QLLK-------EKSSLG---NELKESQLEIIQLKEKERLAKTEQE--TL 593 ++ H Q+ + + SLG NEL S+L +++ E + L KT +E T Sbjct: 424 DESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEM-ENQSLTKTVEELRTT 482 Query: 594 LQIIETVKDEKLNLETTLQESTAARQIMEREI----ENIQTYQS---------------- 633 + +E + L +E Q + +I+E EI +++Q Q+ Sbjct: 483 VDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTI 542 Query: 634 -TAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSK-MVMETKTDNQILKEELKKHSQE 691 T EN ++IK + E ++S + + ++ ++ V + + +N+IL E +K+ S + Sbjct: 543 ETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSK 602 Query: 692 NIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICN 743 K E ++ ++ LE+Y E + LE E+ HL++E L KI N Sbjct: 603 LSKIEFEKRQIKKE---LEHYKEKGERAEE-LENELHHLEKENELLQKKITN 650 Score = 41.6 bits (96), Expect = 0.003 Identities = 55/207 (26%), Positives = 89/207 (42%), Gaps = 21/207 (10%) Query: 530 MSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGN---ELKESQLEIIQLKEKERLA 586 +S+E+ K I ++ E LE+KT QLL K L ELK Q E + L R A Sbjct: 249 LSVELADAKAKIRRLRQE---LEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSA 305 Query: 587 KTEQETLLQIIE-TVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKN 645 + ++ L + E V+ +KL ES +R + + +I+ Y++ EE L+E Sbjct: 306 RMYRDELDALREKAVRVDKL-------ESEVSR--YKERLHDIEFYKARVEE--LKEDNQ 354 Query: 646 AKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTED 705 E K L + + S + E + +N LK +L E I L E+ Sbjct: 355 VLLET---KTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEE 411 Query: 706 KILLENYVRSIENERDTLEFEMRHLQR 732 + LE + +E L +E+ + R Sbjct: 412 NMTLEMAQKQSMDESLHLGWELEQISR 438 >gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sapiens] Length = 1843 Score = 94.7 bits (234), Expect = 3e-19 Identities = 173/822 (21%), Positives = 336/822 (40%), Gaps = 105/822 (12%) Query: 45 ESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKS-HHFEDSKTLH 103 E EN+I +S +K +L + + Q + + E E +E HH E L Sbjct: 586 EKENKILHES-IKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELL 644 Query: 104 S---VEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRT--STDNLSSNIIIHPSENSDILK 158 K++ + + +L Q S++ E+ +T S NL+ + ENS + + Sbjct: 645 QKKITNLKITCEKIEALEQE---NSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDE 701 Query: 159 NYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKS 218 R + + M A + +K + K + L+ + S K+ E L+ S Sbjct: 702 ENLELRRNVESLKCASMKMAQLQLENKE---LESEKEQLKKGLELLKASFKKT-ERLEVS 757 Query: 219 HDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNF-IKEENLDGNLNE-DIKSKRIS 276 + G L E Q LQ + N + + + + ++ + L NL E I SKR+ Sbjct: 758 YQG---LDIENQRLQKTLE---NSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLE 811 Query: 277 ELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKF 336 +LE K L + K ++ K+L + + E+NN +I K L Sbjct: 812 QLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSK 871 Query: 337 HSRVPRYTLSFLDQTKHEMKDKERQP------FLVKQGSIISENEKTSKVNSVTEQCVAK 390 + + + L + + E K+ ++ + + ++SE KT ++N+ E+ + Sbjct: 872 EIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHE 931 Query: 391 IQY--------------------------LQNYLKESVQI-QKKVMELES---ENLNLKS 420 ++ L++ LK+S++I ++K+ LE+ E+ N Sbjct: 932 LEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQ 991 Query: 421 KMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNV 480 +++ + T + + ++ + + + +V+ I + +K E S+E +E K+ + Sbjct: 992 QLRQELKTVKKNYEALKQRQDE-ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIE 1050 Query: 481 LQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTN 540 ++ N TL+ + L + +Q+ + L+++ Q + +N + + ++ Sbjct: 1051 VERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVE 1110 Query: 541 ILLIQDEKEMLEKKTHQLLKEKSSLGNE----LKESQ----LEIIQLKEKERL------A 586 + + L + QLL ++SSL NE +KE + L +K+ E+L Sbjct: 1111 NSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQ 1170 Query: 587 KTEQETLLQIIETVKDEKLNLETTLQE-STAARQIMER--EIENIQTYQSTAEENFLQEI 643 +E E+L+ T+K NLE ++ Q++++ ++E+++ +E L E Sbjct: 1171 ASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLEN 1230 Query: 644 KNAKSEASIYKNSLSEIGKECEMLSKMVMET---KTDNQILKEELKKHSQENIKFENSIS 700 KN ++ A+ YK E + S+++ ET +TD++ LK L E + E S Sbjct: 1231 KNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFS 1290 Query: 701 RLTED-------KILLENYVRSIENERDTLEFEMRHL--QREYLSLSDKICNQHNDPSK- 750 +L E L N + + LE E RHL Q + L L ++ + N SK Sbjct: 1291 KLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKD 1350 Query: 751 ------TTYISR-------REKFH---FDNYTHEDTSSPQSR 776 YI + +EK D Y D S P+ R Sbjct: 1351 LFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRR 1392 Score = 77.4 bits (189), Expect = 5e-14 Identities = 78/367 (21%), Positives = 167/367 (45%), Gaps = 39/367 (10%) Query: 394 LQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTI 453 L++ L+ + K+ ELE ENL LK+K+ + + + K+++ L+EE T+ Sbjct: 363 LEDQLEGTRARSDKLHELEKENLQLKAKL-------HDMEMERDMDRKKIEELMEENMTL 415 Query: 454 QSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTL--------EEKNIQLSLEKQQMMEA 505 + ++ + S E ++I + + K+L + ++L +E Q + + Sbjct: 416 EMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKT 475 Query: 506 LDQLKSKEHKTQ---SDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEK 562 +++L++ + S + + EN R+S ++E ++ I+ + + + + L+KEK Sbjct: 476 VEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEK 535 Query: 563 SSLGNELKESQLEIIQLKEKERLAKTEQET--LLQIIETVKD-EKLNLETTLQESTAARQ 619 + L E +E ++ + ++ EQE L Q + +++ +++ E +++ + Sbjct: 536 AQL-----EKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENK 590 Query: 620 IMEREIENIQTYQSTAE------ENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVME 673 I+ I+ + S E + L+ K A +N L + KE E+L K + Sbjct: 591 ILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKI-- 648 Query: 674 TKTDNQILKEELKKHSQENIKFENSISRLTEDKILLEN---YVRSIENERDTLEFEMRHL 730 T+ +I E+++ QEN + E +L + +N + S+E E L+ E L Sbjct: 649 --TNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLEL 706 Query: 731 QREYLSL 737 +R SL Sbjct: 707 RRNVESL 713 Score = 75.9 bits (185), Expect = 1e-13 Identities = 151/692 (21%), Positives = 286/692 (41%), Gaps = 146/692 (21%) Query: 199 ENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIK 258 E L DI K EEL++ D +V L E +T+ D + + + DK++ ++ Sbjct: 334 ERLHDI-EFYKARVEELKE--DNQVLL--ETKTMLED-------QLEGTRARSDKLHELE 381 Query: 259 EENL-------DGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSK-SE 310 +ENL D + D+ K+I EL L ++ +H + +++S+ SE Sbjct: 382 KENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSE 441 Query: 311 MHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSI 370 + + ++ +T + L+ ++ L +T E++ Sbjct: 442 LSEAPQKSLGHEVNELTSSRLLKLEMENQS-------LTKTVEELR-------------- 480 Query: 371 ISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENL-------NLKSKMK 423 + V+SV E +KI ++ KE+ ++ KKV LE+E + N ++ K Sbjct: 481 -------TTVDSV-EGNASKILKME---KENQRLSKKVEILENEIVQEKQSLQNCQNLSK 529 Query: 424 PLIFTTQSLIQKVETY----EKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYN 479 L+ L + +ET E+Q+K L +E + +S + S+ + K I K N Sbjct: 530 DLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKEN 589 Query: 480 -VLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMK 538 +L K K ++ EK+Q+ + L+ K K + + + NE + + E E ++ Sbjct: 590 KILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEE----LENELHHLEKENELLQ 645 Query: 539 ---TNILLIQDEKEMLE-------------KKT-----------HQLLKEKSSLGNE--- 568 TN+ + ++ E LE KKT L KE S L E Sbjct: 646 KKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLE 705 Query: 569 -------LKESQLEIIQLKEKERLAKTEQETLLQIIETVKD-----------------EK 604 LK + +++ QL+ + + ++E+E L + +E +K E Sbjct: 706 LRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIEN 765 Query: 605 LNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKEC 664 L+ TL+ S Q +E E+++++ T ++N L+E+K + + + +E Sbjct: 766 QRLQKTLENSNKKIQQLESELQDLEMENQTLQKN-LEELKISSKRLEQLEKENKSLEQET 824 Query: 665 EMLSKMVMETKTDNQILKE--ELKKHSQE--NIKFEN----SISRLTEDKILLENYVRSI 716 L K + + +N+ L++ E+K + E N+K N + + E I E+ VR Sbjct: 825 SQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLK 884 Query: 717 ENERDTLEFEMR---------HLQREYLSLSDKICNQHNDPSKTTYISRREKFHFDNYTH 767 E E++ E R L+ + +S K +ND K T+ + + + H Sbjct: 885 ELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLH 944 Query: 768 EDTSSPQSR------PLASDLKGYFKVKDRTL 793 ++ S+ SR L S LK ++K+ + Sbjct: 945 DEQSTDDSRYKLLESKLESTLKKSLEIKEEKI 976 Score = 70.1 bits (170), Expect = 8e-12 Identities = 95/412 (23%), Positives = 185/412 (44%), Gaps = 65/412 (15%) Query: 378 SKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVE 437 +K+ + ++ K + L + +E Q++ ++ L+ EN+NL S + L + Sbjct: 258 AKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDEL-DALR 316 Query: 438 TYEKQLKNLVEEKSTIQSKLSKTEEYSK--ECLKEFKKIISKYNVLQGQNKTLEEKNIQL 495 ++ L E S + +L E Y E LKE +++ + KT+ E ++ Sbjct: 317 EKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLL-------ETKTMLEDQLEG 369 Query: 496 SLEKQQMMEALD----QLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEML 551 + + + L+ QLK+K H + + + +R IE E M+ N+ L +K+ + Sbjct: 370 TRARSDKLHELEKENLQLKAKLHDME-----MERDMDRKKIE-ELMEENMTLEMAQKQSM 423 Query: 552 EKKTH------QLLK-------EKSSLG---NELKESQLEIIQLKEKERLAKTEQE--TL 593 ++ H Q+ + + SLG NEL S+L +++ E + L KT +E T Sbjct: 424 DESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEM-ENQSLTKTVEELRTT 482 Query: 594 LQIIETVKDEKLNLETTLQESTAARQIMEREI----ENIQTYQS---------------- 633 + +E + L +E Q + +I+E EI +++Q Q+ Sbjct: 483 VDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTI 542 Query: 634 -TAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSK-MVMETKTDNQILKEELKKHSQE 691 T EN ++IK + E ++S + + ++ ++ V + + +N+IL E +K+ S + Sbjct: 543 ETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSK 602 Query: 692 NIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICN 743 K E ++ ++ LE+Y E + LE E+ HL++E L KI N Sbjct: 603 LSKIEFEKRQIKKE---LEHYKEKGERAEE-LENELHHLEKENELLQKKITN 650 Score = 41.6 bits (96), Expect = 0.003 Identities = 55/207 (26%), Positives = 89/207 (42%), Gaps = 21/207 (10%) Query: 530 MSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGN---ELKESQLEIIQLKEKERLA 586 +S+E+ K I ++ E LE+KT QLL K L ELK Q E + L R A Sbjct: 249 LSVELADAKAKIRRLRQE---LEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSA 305 Query: 587 KTEQETLLQIIE-TVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKN 645 + ++ L + E V+ +KL ES +R + + +I+ Y++ EE L+E Sbjct: 306 RMYRDELDALREKAVRVDKL-------ESEVSR--YKERLHDIEFYKARVEE--LKEDNQ 354 Query: 646 AKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTED 705 E K L + + S + E + +N LK +L E I L E+ Sbjct: 355 VLLET---KTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEE 411 Query: 706 KILLENYVRSIENERDTLEFEMRHLQR 732 + LE + +E L +E+ + R Sbjct: 412 NMTLEMAQKQSMDESLHLGWELEQISR 438 >gi|71061468 centromere protein E [Homo sapiens] Length = 2701 Score = 94.0 bits (232), Expect = 5e-19 Identities = 168/792 (21%), Positives = 334/792 (42%), Gaps = 110/792 (13%) Query: 24 LNSSEGVKESGCSDTE-YGCIAESENQIQPQSALKVLQQQ-LES-FQALRMQ----TLQN 76 +N + ES CS+++ + ++ ++I+ A K+L Q+ +ES +LR L Sbjct: 455 INLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDY 514 Query: 77 VSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLR 136 + TE +E L +++ + ++ + L E K D L ++ + + + Sbjct: 515 EQLRTEKEEMELKLKEKNDLDEFEAL---ERKTKKDQEMQLIHEISNLKNLVKHAEVYNQ 571 Query: 137 TSTDNLSSNIIIHPSENSDILKNYNNF--------------YRFLPTAPPNVMSQ----A 178 + LSS + + E D +K + Y P M Q A Sbjct: 572 DLENELSSKVELL-REKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDA 630 Query: 179 DTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDV 238 +TV LD + + FL+ ENL+ +KE++++ + N++Q Q+ + Sbjct: 631 ETVALDAKRESA-FLRS---ENLE--------LKEKMKELATTYKQMENDIQLYQSQLEA 678 Query: 239 HRNGKYDMSPIHQDKMNFIKEEN--LDGNLNEDIK----------------SKRISELEA 280 + + D+ Q N I + +DG + +D+ +K + E EA Sbjct: 679 KKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEA 738 Query: 281 LVKKLLPFRETVS-KFHVHFCRKCKKLSKSEMHR-GKKNEKNNKEIPITGKNITDLKFHS 338 L ++++ E S V RK + E+H + +K E+ + L Sbjct: 739 LREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEI 798 Query: 339 RVPRYTLSFLDQTKHEMKDKERQPFLV-------KQGSIISENEKTSKVNSVTEQCVAKI 391 + L+ Q+ ++ D+E Q F K ++ ENE+ ++ + K Sbjct: 799 GKTKDDLA-TTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKF 857 Query: 392 QYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKS 451 LK ++ K EL+ + ++ ++ + + L +++E + L+ + EK+ Sbjct: 858 DSSLGALK--TELSYKTQELQEKTREVQERLNEM----EQLKEQLENRDSTLQTVEREKT 911 Query: 452 TIQSKLSKTEEYSKECLKE---FKKIISKYNVLQGQNKTLEEKNIQLSLEKQ-QMMEALD 507 I KL +T E K +E K++ + + Q K+ + ++++ Q Q+ AL+ Sbjct: 912 LITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALE 971 Query: 508 QLKSKEHKTQSDMAIVNNENNR-MSIEMEAMKTNILLIQ-----DEKEMLEKKTHQLLKE 561 LK + + + ++ E +R + +E +T Q D+K+ LE K Q L Sbjct: 972 SLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTA 1031 Query: 562 KSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIM 621 NE+ E Q +I L + E+ L Q++E+V EK L+T L+E+ + Sbjct: 1032 DVK-DNEIIEQQRKIFSLIQ-------EKNELQQMLESVIAEKEQLKTDLKEN------I 1077 Query: 622 EREIENIQTYQSTAEE-NFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQI 680 E IEN + + +E QEI + +I K E+ + C+ L+++ + K +Q Sbjct: 1078 EMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEG--ELSRTCDRLAEVEEKLKEKSQQ 1135 Query: 681 LKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDK 740 L+E+ Q+ + + +S + + KI N + +++NE E + H++ E L L+ K Sbjct: 1136 LQEK----QQQLLNVQEEMSEM-QKKI---NEIENLKNELKNKELTLEHMETERLELAQK 1187 Query: 741 ICNQHNDPSKTT 752 + + + T Sbjct: 1188 LNENYEEVKSIT 1199 Score = 89.7 bits (221), Expect = 9e-18 Identities = 153/715 (21%), Positives = 295/715 (41%), Gaps = 104/715 (14%) Query: 45 ESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHS 104 E +N + AL+V QL+ + +R +TL + QE++L+M++ +D++T Sbjct: 1350 ERDNLKTIKEALEVKHDQLK--EHIR-ETLAKIQESQSKQEQSLNMKE----KDNETTKI 1402 Query: 105 VEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTD--NLSSNIIIHPSENSDILKNYNN 162 V E Q +D+ LR + LS + E + K ++ Sbjct: 1403 VSEM----------------EQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDD 1446 Query: 163 FYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHS-IKQMKEELQKSHDG 221 R + S++D + K I KH E + H +K+ +E + + Sbjct: 1447 LQRLQEV----LQSESDQL---KENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVN 1499 Query: 222 EVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEAL 281 E+ T+Q + N K Q+K+ I E+ E K+ISE++ Sbjct: 1500 LSEKETEISTIQKQLEAI-NDKL------QNKIQEIYEKE------EQFNIKQISEVQEK 1546 Query: 282 VKKLLPFRETVSKFHVHFCRKCK-----KLSKSEMHRGKKNEKNNKEIPITGKNITDLKF 336 V +L F+E RK K + + + +++ +EI I K ++K Sbjct: 1547 VNELKQFKEH---------RKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMK- 1596 Query: 337 HSRVPRYTLSFLDQTKHEMKD--------KERQPFLVKQGSIISENEKTSKVNSVTEQCV 388 RV DQ K K+ +E++ +K ++ EK ++ + EQ Sbjct: 1597 --RVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFE 1654 Query: 389 AKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVE 448 + L+N E++++ + + E E ++ + L ++L KVE QLK + Sbjct: 1655 TQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETL--KVE--RDQLKENLR 1710 Query: 449 EKSTIQSKLSKTEEYS--KECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEAL 506 E TI L K EE LKE ++ I K + + KT E N+Q LE Sbjct: 1711 E--TITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSE-KTNEISNMQKDLEHSN----- 1762 Query: 507 DQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLG 566 D LK+++ K Q ++ I + ++ ++ + D+ ++K + Sbjct: 1763 DALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKI 1822 Query: 567 NELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIE 626 ELK ++ ++I LK+ + + + Q+ + +KD+ L L + EIE Sbjct: 1823 QELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLS-------------KLEIE 1869 Query: 627 NIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELK 686 N+ Q E L+E+K+ E + + E + L + + ETK + +++ELK Sbjct: 1870 NLNLAQKLHEN--LEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELK 1927 Query: 687 KHSQENIKFENSISRL----TEDKILLENYVRSIENERDTLEFEMRHLQREYLSL 737 + + + ++ +L +E I + + + ++ +D L+ +++ LQ++ L L Sbjct: 1928 TARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQL 1982 Score = 86.3 bits (212), Expect = 1e-16 Identities = 164/752 (21%), Positives = 311/752 (41%), Gaps = 108/752 (14%) Query: 59 LQQQLESFQA----LRMQTLQNVSMPTENQEEN-------------LSMEKSHHF----E 97 LQQ LES A L+ +N+ M ENQEE ++ EK+H E Sbjct: 1055 LQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGE 1114 Query: 98 DSKT---LHSVEEKLSGDSVN---SLPQSVNVPSQIHS-----EDTLTLRTSTDNLSSNI 146 S+T L VEEKL S Q +NV ++ + L+ N + Sbjct: 1115 LSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTL 1174 Query: 147 IIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICH 206 +E ++ + N Y + + + K + + L+ F D + Sbjct: 1175 EHMETERLELAQKLNENYEEVKS-------------ITKERKVLKELQKSFETERDHLRG 1221 Query: 207 SIKQMKEE-LQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGN 265 I++++ LQ + ++A + + +T ++ R+ + I +N E Sbjct: 1222 YIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQI----INTQDLEKSHTK 1277 Query: 266 LNEDIKS-KRISELEALVKKLLPFRETVSKFHVHFCRKCKK----LSKSEMHRGKKNEK- 319 L E+I EL VK++ +ET+++ + + K L++ EM R + NEK Sbjct: 1278 LQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKF 1337 Query: 320 --NNKEIPITGKNITDLKF--------HSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGS 369 + +EI K +LK H ++ + L + + E + K+ Q +K+ Sbjct: 1338 QESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQ-ESQSKQEQSLNMKEKD 1396 Query: 370 -----IISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVME-----------LES 413 I+SE E+ +S + ++ L L+ES K V + L+S Sbjct: 1397 NETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQS 1456 Query: 414 ENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKK 473 E+ LK +K ++ ++++ LK E + ++ LS+ E K+ + Sbjct: 1457 ESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEA 1516 Query: 474 IISKY-NVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSI 532 I K N +Q + E+ NI+ E Q+ + L Q KEH+ D A+ + E+ + + Sbjct: 1517 INDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQF--KEHRKAKDSALQSIESKMLEL 1574 Query: 533 --EMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKE-----RL 585 ++ + I ++ EKE +++ L E+ L KE ++ + +EKE Sbjct: 1575 TNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMT 1634 Query: 586 AKTEQETLLQIIETVKD----EKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQ 641 A E + + IE +K+ +KLNLE E+ QI+ EN++ +S +E Sbjct: 1635 AVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILH---ENLEEMRSVTKER--D 1689 Query: 642 EIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISR 701 ++++ + + ++ L E +E +E + + +I+ LK+H + K +S Sbjct: 1690 DLRSVEETLKVERDQLKENLRETITRD---LEKQEELKIVHMHLKEHQETIDKLRGIVSE 1746 Query: 702 LTEDKILLENYVRSIENERDTLEFEMRHLQRE 733 T + + N + +E+ D L+ + +Q E Sbjct: 1747 KTNE---ISNMQKDLEHSNDALKAQDLKIQEE 1775 Score = 77.8 bits (190), Expect = 4e-14 Identities = 152/742 (20%), Positives = 304/742 (40%), Gaps = 116/742 (15%) Query: 53 QSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGD 112 QS K Q+ ++F+ L M Q M E + E ++ E + ++++ S Sbjct: 809 QSNYKSTDQEFQNFKTLHMDFEQKYKMVLE-ENERMNQEIVNLSKEAQKFDS-------- 859 Query: 113 SVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPP 172 S+ +L ++ +Q E T ++ + + + EN D + Sbjct: 860 SLGALKTELSYKTQELQEKTREVQERLNEMEQ--LKEQLENRD--------------STL 903 Query: 173 NVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTL 232 + + T+I +K + T+ +K + DD+ KQ++E LQ D + ++ + Sbjct: 904 QTVEREKTLITEKLQQTLEEVKT-LTQEKDDL----KQLQESLQIERDQLKSDIHDTVNM 958 Query: 233 QTDPDVHRNGKYDMSPIHQDKMNFIKE---ENLDGNLN---------------------- 267 D + HQ+ +N +K E + NL+ Sbjct: 959 NIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKK 1018 Query: 268 EDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNN------ 321 +D+++K L A VK E + + F +K +M EK Sbjct: 1019 QDLEAKNTQTLTADVKD----NEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLK 1074 Query: 322 KEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVN 381 + I +T +N +L+ + + Q K+ KE + L + ++E E+ K+ Sbjct: 1075 ENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGE--LSRTCDRLAEVEE--KLK 1130 Query: 382 SVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSL-IQKVETYE 440 ++Q K Q L N +E ++QKK+ E+E NLK+++K T + + +++E + Sbjct: 1131 EKSQQLQEKQQQLLNVQEEMSEMQKKINEIE----NLKNELKNKELTLEHMETERLELAQ 1186 Query: 441 KQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQ 500 K +N E KS ++K + KE K F+ ++ + L+G + +E +Q E + Sbjct: 1187 KLNENYEEVKS-----ITKERKVLKELQKSFE---TERDHLRGYIREIEATGLQTKEELK 1238 Query: 501 QMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLK 560 + + KEH+ D E R E A N ++ L+++ L + Sbjct: 1239 -----IAHIHLKEHQETID------ELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHE 1287 Query: 561 EKSSLGN--ELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAAR 618 E+ L N E+ E+Q + +L+ + T+ T L IE E+L L QES Sbjct: 1288 EQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEM---ERLRLNEKFQESQEEI 1344 Query: 619 QIMEREIENIQTYQSTAE----------ENFLQEIKNAKSEASIYKNSLSEIGKECEMLS 668 + + +E +N++T + E L +I+ ++S+ N + + +++S Sbjct: 1345 KSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVS 1404 Query: 669 KMVMETKTDNQILKEE-----LKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTL 723 +M D+ +L+ E L K QE+ S+++ +D L+ +++E D L Sbjct: 1405 EMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDD---LQRLQEVLQSESDQL 1461 Query: 724 EFEMRHLQREYLSLSDKICNQH 745 + ++ + ++L +++ H Sbjct: 1462 KENIKEIVAKHLETEEELKVAH 1483 Score = 75.1 bits (183), Expect = 2e-13 Identities = 140/639 (21%), Positives = 284/639 (44%), Gaps = 104/639 (16%) Query: 208 IKQMKEEL--QKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMN---FIKEENL 262 IK+++E + QK + ++ L+ L++++ DP + +D + D F++ ENL Sbjct: 591 IKKLQEYIDSQKLENIKMDLSYSLESIE-DPKQMKQTLFDAETVALDAKRESAFLRSENL 649 Query: 263 DGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKN-N 321 + L E +K EL K++ +L +S++ KK + + Sbjct: 650 E--LKEKMK-----ELATTYKQM---------------ENDIQLYQSQLEAKKKMQVDLE 687 Query: 322 KEIPITGKNITDLK--FHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSK 379 KE+ IT L +VP+ L L+ E K + Q L K+ + ENE Sbjct: 688 KELQSAFNEITKLTSLIDGKVPKDLLCNLEL---EGKITDLQKELNKE---VEENE---- 737 Query: 380 VNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETY 439 + V + L++ E +++K++ + +SE L++ + K +F+ +V Sbjct: 738 ---ALREEVILLSELKSLPSEVERLRKEIQD-KSEELHIITSEKDKLFS------EVVHK 787 Query: 440 EKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIIS-------KYNVLQGQNKTLEEKN 492 E +++ L+EE + L+ T+ K +EF+ + KY ++ +N+ + ++ Sbjct: 788 ESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEI 847 Query: 493 IQLSLEKQQMMEALDQLKSK-EHKTQS------DMAIVNNENNRMSIEMEAMKTNILLIQ 545 + LS E Q+ +L LK++ +KTQ ++ NE ++ ++E + + ++ Sbjct: 848 VNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVE 907 Query: 546 DEKEMLEKKTHQLLKEKSSLGNE---LKESQLEIIQLKEKERLAKTEQETLLQIIETVKD 602 EK ++ +K Q L+E +L E LK+ Q E +Q+ E+++L +T+ I+T + Sbjct: 908 REKTLITEKLQQTLEEVKTLTQEKDDLKQLQ-ESLQI-ERDQLKSDIHDTVNMNIDTQEQ 965 Query: 603 EKLNLETTLQE----STAARQIMEREIENIQTYQSTAE--ENFLQ-----------EIKN 645 + LE+ Q +T +I E N+ ++T E + F Q E KN Sbjct: 966 LRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKN 1025 Query: 646 AKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQIL------KEELKKHSQENIKFENSI 699 ++ + K+ +EI ++ + ++ E Q+L KE+LK +ENI E +I Sbjct: 1026 TQTLTADVKD--NEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENI--EMTI 1081 Query: 700 SRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLS---DKICNQHNDPSKTTYISR 756 E ++L + ++ +++ + E H ++ LS D++ + + + Sbjct: 1082 ENQEELRLLGD----ELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQ 1137 Query: 757 REKFHFDNYTHEDTSSPQSRPLASDLKGYFKVKDRTLKH 795 ++ N E + + +LK K K+ TL+H Sbjct: 1138 EKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEH 1176 Score = 60.8 bits (146), Expect = 5e-09 Identities = 117/623 (18%), Positives = 247/623 (39%), Gaps = 92/623 (14%) Query: 210 QMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNED 269 Q+KE LQ++ ++ + EL+T + H+ + +K I + D + ++D Sbjct: 1907 QLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKD 1966 Query: 270 IKSKRISELEALVKKLLPFRETVSKFH--VHFCRKCKKLSKSE-----------MHRGKK 316 K+I EL+ +LL +E V+ H ++ + KK +++ KK Sbjct: 1967 ELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKK 2026 Query: 317 NEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEK 376 ++ +EI I K +L+ + T EM ++RQ VK + + + Sbjct: 2027 LHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQ 2086 Query: 377 TSKVNSVTEQCVAKIQYLQNY----------------LKESVQIQKKVMELESENLNLKS 420 S+ E+C + L+ Y L++ ++ QK++ NL+L Sbjct: 2087 QHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPY 2146 Query: 421 KMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEF--------- 471 I + L + + ++++ + S ++K +E E + +F Sbjct: 2147 LQTKHI---EKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVE 2203 Query: 472 --KKIISKYNVLQ---------------GQNKTLEEKNI----------QLSLEKQQMM- 503 K+++ K LQ QN L + I + E QQ++ Sbjct: 2204 KQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLS 2263 Query: 504 --EALDQLKSKEHKTQSDMAIVNN----ENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQ 557 + + Q + T+ D+ + N EN+R+ I+ I +E E+++ Sbjct: 2264 NRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSAT 2323 Query: 558 LLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAA 617 + KE LKE ++ + + KT + Q+ T +D K T+ Sbjct: 2324 ISKEWEQDLKSLKEKNEKLFK---NYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTT 2380 Query: 618 RQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTD 677 +I RE+EN + + +I + E + + ++++ + +K + +TK Sbjct: 2381 EKI--RELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKET 2438 Query: 678 NQILKEEL----KKHSQENIKFENSISRLTEDKIL-LENYVRSIENERDTLEF--EMRHL 730 Q+L++++ K + +E + + ++ +K+ + + + I + T+E+ E+ L Sbjct: 2439 IQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRL 2498 Query: 731 QREYLSLSDK-----ICNQHNDP 748 RE L S + + ++H DP Sbjct: 2499 LRENLRRSQQAQDTSVISEHTDP 2521 Score = 54.7 bits (130), Expect = 3e-07 Identities = 149/787 (18%), Positives = 325/787 (41%), Gaps = 128/787 (16%) Query: 1 MSPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQ 60 +S +Q +++ + S+ LS +I N + K + + E +N + + LK+ + Sbjct: 1846 VSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLER 1905 Query: 61 QQL-ESFQALR------MQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDS 113 QL ES Q + Q L+ M ++ +E + + E + + +++ L S Sbjct: 1906 DQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLD-KS 1964 Query: 114 VNSLPQSVNVPSQIHSEDTLTLRTSTD-NLSSNIIIHPSENSDILKNYNNFYRFLPTAPP 172 + L + + ++ ++ LR D N+S I +E + K + Sbjct: 1965 KDELQKKIQ---ELQKKELQLLRVKEDVNMSHKKI---NEMEQLKKQFE---------AQ 2009 Query: 173 NVMSQADTVILDKSKITVPFLKHGFCENLDDICHS---IKQMKEELQKSHDGEVALTNEL 229 N+ Q+ V +D ++T H E + + ++++KE L+ D +A E+ Sbjct: 2010 NLSMQS--VRMDNFQLTKKL--HESLEEIRIVAKERDELRRIKESLKMERDQFIATLREM 2065 Query: 230 -----QTLQTDPDVH--RNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALV 282 Q Q P+ +G+ ++ ++K + IKE KR SE++ Sbjct: 2066 IARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKE-----------LLKRYSEMDDHY 2114 Query: 283 KKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPR 342 + L + K + F ++ K+ + K+ +++ T ++FH + + Sbjct: 2115 ECLNRLSLDLEK-EIEFQKELSMRVKANLSLPYLQTKHIEKL-FTANQRCSMEFHRIMKK 2172 Query: 343 --YTLSFLDQTK---HEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNY 397 Y LS++ + K HE +K F+ + + E K+ + + C + L++ Sbjct: 2173 LKYVLSYVTKIKEEQHESINKFEMDFI---DEVEKQKELLIKIQHLQQDCDVPSRELRD- 2228 Query: 398 LKESVQIQKKVMEL-----ESENLNLKSKMKPLIFTTQSLIQKVETYE------KQLKNL 446 LK + + + E+ ESE ++K++ + ++ + + Q +E + ++LKN Sbjct: 2229 LKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNG 2288 Query: 447 VEEKS---------------TIQSKLSKTEEYSKECLKEFK-----------KIISKYNV 480 +++++ I ++ ++ EE S KE++ K+ Y Sbjct: 2289 IQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQT 2348 Query: 481 L--------QGQNKTLEEKNIQLSLEKQQMM-EALDQLKSKEHKTQSDMAIVNNENNRMS 531 L Q T + KN ++ Q+ E + +L++ H+ + ++ +M Sbjct: 2349 LKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQ 2408 Query: 532 IEMEAMKTNILLIQ----DEKEMLEK--KTHQLLKEKSSLGNELKESQLEIIQLK----- 580 E+E I +Q + + LEK +T Q+L++K +LG + + ++E +++K Sbjct: 2409 KELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKID 2468 Query: 581 -EKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEE-- 637 EK + AK ++ + TV+ +K + + ++Q + + + T + + Sbjct: 2469 LEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPL 2528 Query: 638 ------NFLQEIKNA--KSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHS 689 +Q K KSE + +S++ ++ E L K E ++NQ L E+K Sbjct: 2529 TCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWK 2588 Query: 690 QENIKFE 696 + +K E Sbjct: 2589 ERTLKRE 2595 Score = 36.2 bits (82), Expect = 0.12 Identities = 49/209 (23%), Positives = 91/209 (43%), Gaps = 26/209 (12%) Query: 569 LKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENI 628 LK + EI+ LK++ L + ET Q +E KD+ L L+E +++ +IEN+ Sbjct: 345 LKRYRKEIMDLKKQ--LEEVSLETRAQAME--KDQLAQL---LEEKDLLQKVQNEKIENL 397 Query: 629 QTYQSTAEENFLQEIKNAKSE-------ASIYKNSLSEIGKECEMLSKMVMET-KTDNQI 680 T+ LQ+ AK + I K S + + + + +T K + Sbjct: 398 TRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINL 457 Query: 681 LKEELKKHSQENIKFENSISRLTE------DKIL----LENYVRSIENERDTLEFEMRHL 730 L+E + E+ F N++ L+E K+L +E+ + S+ + D L + L Sbjct: 458 LREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQL 517 Query: 731 QREYLSLSDKICNQHNDPSKTTYISRREK 759 + E + K+ + ND + + R+ K Sbjct: 518 RTEKEEMELKL-KEKNDLDEFEALERKTK 545 >gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] Length = 1411 Score = 93.2 bits (230), Expect = 8e-19 Identities = 184/845 (21%), Positives = 351/845 (41%), Gaps = 152/845 (17%) Query: 1 MSPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGC-IAESENQIQPQSAL--- 56 +S EK +E +V + L S++ E +KE + TE + +++ Q Q Q AL Sbjct: 443 LSSEKLMDKEQQVADLQLKLSRL---EEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQS 499 Query: 57 ---KVLQQQLESFQALRM-----QTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEK 108 K+ + Q + Q LR Q +QN+ + +EN+S+ + ++ + L++ + Sbjct: 500 TTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLE----KEREDLYAKIQA 555 Query: 109 LSGDS--VNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRF 166 G++ +N L + + + ++ T L+ +++ H ++ Sbjct: 556 GEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSES-------HKQAQENLHDQVQEQKAH 608 Query: 167 LPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALT 226 L A V+S +V S++ E+ + + Q+K + + E A T Sbjct: 609 LRAAQDRVLSLETSVNELNSQLN---------ESKEKVSQLDIQIKAKTELLLSAEAAKT 659 Query: 227 NELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLL 286 + LQ D +N D K++ L+ K ++L+ + KL Sbjct: 660 AQRADLQNHLDTAQNALQD------------KQQELN---------KITTQLDQVTAKLQ 698 Query: 287 PFRETVSKFHVHFCR-KCKKLS---KSEMHRG--KKNEKNNKEIPITGKN-ITDLKFHSR 339 +E S+ H K K LS K+E G KK E ++ E+ + + + DL+ + Sbjct: 699 DKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQ 758 Query: 340 VPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISEN----EKTSKVNSVTEQCVAKIQYLQ 395 + T E++ E L + I+S +K S+ +Q + K + + Sbjct: 759 L---------NTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEK 809 Query: 396 NYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQS 455 LK+ + + +++ E LN + I TT + +QKV+ EK+ L+ E ST++ Sbjct: 810 QILKQDFETLSQETKIQHEELNNR------IQTTVTELQKVKM-EKEA--LMTELSTVKD 860 Query: 456 KLSKTEEYSKECLKEFKKIISKYNV-----------------LQGQNKTLEEKNIQLSLE 498 KLSK + K EF+K K +Q +N E+K ++ SLE Sbjct: 861 KLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLE 920 Query: 499 KQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQL 558 K++ EA QLK + + Q + N + E + ++ NI ++ E +K+ L Sbjct: 921 KEK--EASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEAL 978 Query: 559 LKE-------KSSLGNELKESQLEIIQ--LKEKERLA------KTEQETLLQIIETVKDE 603 E K+ L N+L++ + Q EKE+++ + QET Q+ Sbjct: 979 QGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGR 1038 Query: 604 KLNLETTLQESTAARQIMEREIENIQTYQSTA--EENFLQEIKNAKS---------EASI 652 + L T Q+ + + + E++ + ++ + +QE+K AK+ E + Sbjct: 1039 ESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQL 1098 Query: 653 YKN--SLSEIGKECEMLSKMVMETKT------------DNQILK--EELKKHSQENIKFE 696 + +L +I KE + K ++ K+ + +I K EELK H E+IK Sbjct: 1099 QERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIK-- 1156 Query: 697 NSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISR 756 I+ L + K LL ++ + D+L+ + +R L D++ + + K +I + Sbjct: 1157 -EITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQV-KKEEEELKKEFIEK 1214 Query: 757 REKFH 761 K H Sbjct: 1215 EAKLH 1219 Score = 85.5 bits (210), Expect = 2e-16 Identities = 153/694 (22%), Positives = 288/694 (41%), Gaps = 101/694 (14%) Query: 12 EVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQQLESFQALRM 71 E DS+ + ASK E D + ++ +++ K L+ + E + R+ Sbjct: 736 EADSLEVKASK---------EQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRL 786 Query: 72 ------QTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPS 125 + L+++ QEE + K +D +TL S E K+ + +N+ Q+ Sbjct: 787 DLQKKSEALESIKQKLTKQEEEKQILK----QDFETL-SQETKIQHEELNNRIQTTVTEL 841 Query: 126 QIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDK 185 Q + L T + + S+ SD LKN + + + ILD Sbjct: 842 QKVKMEKEALMTELSTVKDKL----SKVSDSLKNSKSEFE-------KENQKGKAAILDL 890 Query: 186 SKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYD 245 K T LKH +++ K++K+ L+K + L EL ++Q +N Sbjct: 891 EK-TCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTL-- 947 Query: 246 MSPIHQDKMNFIKEENLDGNLNE-----DIKSKRISELEALVK-KLLPFRETVSKFHVHF 299 K N +E+ L GN+NE + K K+I L+ +K +L E +K Sbjct: 948 -------KQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQL 1000 Query: 300 CRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKE 359 + ++L+ +E + + N ++ T K + F+ R S L T+ ++K E Sbjct: 1001 TQAAQELA-AEKEKISVLQNNYEKSQETFKQLQS-DFYGRE-----SELLATRQDLKSVE 1053 Query: 360 RQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLK 419 + L ++ I + N+ ++ + E AK Q+ K+ Q+Q++ L+ Sbjct: 1054 EKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQD------ 1107 Query: 420 SKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYN 479 IQK ++ ++ K LV EKS KL++ EE +C +E K I+K N Sbjct: 1108 -------------IQKEKSLKE--KELVNEKS----KLAEIEEI--KCRQE--KEITKLN 1144 Query: 480 VLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKT 539 +K K I + +Q++ + Q + K S A V E I + +K Sbjct: 1145 EELKSHKLESIKEITNLKDAKQLL--IQQKLELQGKADSLKAAVEQEKRNQQILKDQVKK 1202 Query: 540 NILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIET 599 E+E L+K + +++++ L +E+KE ++ + + +E E + L + + T Sbjct: 1203 -------EEEELKK---EFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGT 1252 Query: 600 VKDEKLNLETTLQESTAARQIMEREIENIQ-TYQSTAEEN--FLQEIKNAKSEASIYKNS 656 VK E + + + E + EI ++ T Q+ +E L+ + E + Sbjct: 1253 VKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTK 1312 Query: 657 LSEIGKECEMLSKMVMETKTDNQILKEELKKHSQ 690 + E+ ++ + + V E +NQ L+ KH+Q Sbjct: 1313 VLELQRKLDNTTAAVQELGRENQSLQ---IKHTQ 1343 Score = 68.6 bits (166), Expect = 2e-11 Identities = 74/355 (20%), Positives = 156/355 (43%), Gaps = 25/355 (7%) Query: 390 KIQYLQNYLKESVQIQKKVM-ELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVE 448 ++Q LQ LKE +++ ELE + + KP T S + +++ E+QL+ Sbjct: 91 EVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAE-LQSLEQQLEEAQT 149 Query: 449 EKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQ 508 E I+ E+ + + E I SKY+ + + E+K +L+ E + + Sbjct: 150 ENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQD 209 Query: 509 LKSK--EHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLG 566 LK++ + D+A++ E ++++ + N+ L + E+++ +L E L Sbjct: 210 LKTELLQRPGIEDVAVLKKE----LVQVQTLMDNMTLER------ERESEKLKDECKKLQ 259 Query: 567 NELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIE 626 ++ S+ I QL+ + LAK QE + + E K + E T + T ++++E Sbjct: 260 SQYASSEATISQLRSE--LAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKE-- 315 Query: 627 NIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELK 686 Q Y E++ + + +A++++ L +C+ L + ++T + EL Sbjct: 316 --QDYTKLEEKHNEESVSKKNIQATLHQKDL-----DCQQLQSRLSASETSLHRIHVELS 368 Query: 687 KHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKI 741 + + K + +S + L+ + ++ +R+ E LQ E L K+ Sbjct: 369 EKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKL 423 Score = 67.4 bits (163), Expect = 5e-11 Identities = 142/770 (18%), Positives = 313/770 (40%), Gaps = 103/770 (13%) Query: 59 LQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKT----LHSVEEKLSGDSV 114 L+++LE +Q L+ Q + + T++ E S+E+ E+++T + +++ + Sbjct: 109 LKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQ--QLEEAQTENFNIKQMKDLFEQKAA 166 Query: 115 NSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNV 174 + ++ S+ E +LR + + + + ++ + ++++ P Sbjct: 167 QLATEIADIKSKYDEE--RSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVA 224 Query: 175 MSQADTVILDKSKITVPFLKHGFCENLDDICH-----------SIKQMKEELQKSHDGEV 223 + + + V + + + E L D C +I Q++ EL K Sbjct: 225 VLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVA 284 Query: 224 ALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEE----NLDGNLNEDIKSK------ 273 ELQ L++ + ++ N +K+E L+ NE+ SK Sbjct: 285 VYVQELQKLKSSVNELTQKNQTLTE------NLLKKEQDYTKLEEKHNEESVSKKNIQAT 338 Query: 274 ---RISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKN 330 + + + L +L ++ + HV K + K + + E + + K Sbjct: 339 LHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEV-ETKYQHLKAEFKQ 397 Query: 331 ITDLKFHSRVPRYTL-SFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVA 389 + + L S ++Q ++ + ERQ G + + + +S+ EQ VA Sbjct: 398 LQQQREEKEQHGLQLQSEINQLHSKLLETERQ-LGEAHGRLKEQRQLSSEKLMDKEQQVA 456 Query: 390 ----KIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKN 445 K+ L+ LKE V ++ + + + L +T + +++ + +Q+ Sbjct: 457 DLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLR 516 Query: 446 LVEEK----STIQSKLSKTEEYSKECLKEFKKIISK----------YNVLQGQNKTLEEK 491 + +K +++ L K++E KE + + +K N LQ +N TL+E+ Sbjct: 517 QIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQ 576 Query: 492 NIQLS--LEKQ-------------QMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEA 536 QL+ L+ Q Q+ E L++ + + S VN N++++ E Sbjct: 577 VTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEK 636 Query: 537 MKTNILLIQDEKEML----EKKTHQ---LLKEKSSLGNELKESQLEI----IQLKEKERL 585 + + I+ + E+L KT Q L + N L++ Q E+ QL + Sbjct: 637 VSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAK 696 Query: 586 AKTEQETLLQI---IETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQE 642 + +QE Q+ ++ K++ L+LE +E QI + E ++++ ++E LQ+ Sbjct: 697 LQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEG--QIKKLEADSLEV--KASKEQALQD 752 Query: 643 IKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQ-------ILKEELKKHSQENIKF 695 ++ + + + +E+ K+ EM ++V T+ D Q +K++L K +E Sbjct: 753 LQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQIL 812 Query: 696 ENSISRLTEDKIL----LENYVRSIENERDTLEFEMRHLQREYLSLSDKI 741 + L+++ + L N +++ E ++ E L E ++ DK+ Sbjct: 813 KQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKL 862 >gi|41872583 Rho-associated, coiled-coil containing protein kinase 2 [Homo sapiens] Length = 1388 Score = 91.7 bits (226), Expect = 2e-18 Identities = 118/591 (19%), Positives = 255/591 (43%), Gaps = 94/591 (15%) Query: 199 ENLDDICHSIKQMKEELQKSHDGEVALTNELQT----LQTDPDV--HRNGKYDMSPIHQD 252 E L+ C S+ E+ K + E+ L +++ L+ + + H+N +Y H+ Sbjct: 464 EELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEA 523 Query: 253 KMNFIKEENLDGNLN------EDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKL 306 K+ NL+ ++N ED+K KR + +K+ + + + + L Sbjct: 524 D----KKRNLENDVNSLKDQLEDLK-KRNQNSQISTEKVNQLQRQLDETNA--------L 570 Query: 307 SKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVK 366 ++E + K E + K I L+ ++R + L+ K +++ + F+ Sbjct: 571 LRTESDTAARLRKTQAE---SSKQIQQLESNNRDLQDKNCLLETAKLKLEKE----FINL 623 Query: 367 QGSIISENEKTSKVNSVTEQCVAKIQYLQNYLK-----------ESVQIQKKVMELESEN 415 Q ++ SE + + + +I L+ LK E Q+Q++ +LE E Sbjct: 624 QSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEK 683 Query: 416 LNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKII 475 N++ M + Q +++ E K K + +K+ I + EE E +KE +K + Sbjct: 684 SNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESI---EEAKSEAMKEMEKKL 740 Query: 476 SKYNVLQGQ--------------------------NKTLEEKNIQLSLEKQQMMEALDQL 509 + L+ + N+ L++K++ L+ + + + ++Q Sbjct: 741 LEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDV-LNEDVRNLTLKIEQE 799 Query: 510 KSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNEL 569 K TQ+D+ + + N + + + +K + + K LEK+ +L KE+ ++ Sbjct: 800 TQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQM 859 Query: 570 KESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQ 629 KE Q ++ E E+ T +T ++ ++ +EK L LQ+ ++E+++ + Sbjct: 860 KELQDQL----EAEQYFSTLYKTQVRELKEECEEKTKLGKELQQK-------KQELQDER 908 Query: 630 TYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHS 689 + E L + + + SI + S++ KE K++ E + +KE + +H Sbjct: 909 DSLAAQLEITLTKADSEQLARSIAEEQYSDLEKE-----KIMKELE-----IKEMMARHK 958 Query: 690 QENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDK 740 QE + + +I+ L E L + V ++ NE++ L +++ +Q + L D+ Sbjct: 959 QELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDE 1009 Score = 60.5 bits (145), Expect = 6e-09 Identities = 148/770 (19%), Positives = 309/770 (40%), Gaps = 124/770 (16%) Query: 5 KQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIA----------ESENQIQPQS 54 +++ E E+ L + + L++ KE + E C + E E +I + Sbjct: 437 RKNEESQEIQKKLYTLEEHLSNEMQAKE----ELEQKCKSVNTRLEKTAKELEEEITLRK 492 Query: 55 ALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSV 114 +++ +QLE +AL LQ+ + + + ++ + +K + D +L E L + Sbjct: 493 SVESALRQLEREKAL----LQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQ 548 Query: 115 NSL--PQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPP 172 NS + VN + E LRT +D ++ + +E+S ++ + R L Sbjct: 549 NSQISTEKVNQLQRQLDETNALLRTESDT-AARLRKTQAESSKQIQQLESNNRDLQDK-- 605 Query: 173 NVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTL 232 N + + + L+K I NL S E ++H E+ + + Sbjct: 606 NCLLETAKLKLEKEFI-----------NLQSALES-----ERRDRTHGSEIINDLQGRIC 649 Query: 233 QTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETV 292 + D+ +NGK ++ + +K L + K K E++ + + + Sbjct: 650 GLEEDL-KNGKILLAKVELEK------RQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLE 702 Query: 293 SKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTL------S 346 + H K + K++++ + K+ + K + + +V L S Sbjct: 703 QEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCS 762 Query: 347 FLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQ--- 403 LD + + K + L+KQ ++ NE + EQ K QN LK Q Sbjct: 763 LLDCDLKQSQQKINE--LLKQKDVL--NEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVN 818 Query: 404 -IQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQ--SKLSKT 460 ++ +L+ EN +L L L ++ + + Q+K L ++ Q S L KT Sbjct: 819 TLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKT 878 Query: 461 E--EYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQS 518 + E +EC ++ K K L++K +L E+ + L+ +K Q Sbjct: 879 QVRELKEECEEKTKL-----------GKELQQKKQELQDERDSLAAQLEITLTKADSEQL 927 Query: 519 DMAIVNNENNRMSIE--MEAMKTNILLIQDEKEMLEKKTH----------------QLLK 560 +I + + + E M+ ++ ++ + ++E+ EK L Sbjct: 928 ARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLAN 987 Query: 561 EKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQI 620 EK L N+LK+ Q ++ +LK++E A I+ +++L E TL+ Sbjct: 988 EKEELNNKLKDVQEQLSRLKDEEISAAA--------IKAQFEKQLLTERTLK-------- 1031 Query: 621 MEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQI 680 T N L EI N K + + + +++ ++ + K+ ME K++ + Sbjct: 1032 -------------TQAVNKLAEIMNRKE--PVKRGNDTDVRRKEKENRKLHMELKSEREK 1076 Query: 681 LKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHL 730 L +++ K+ +E + + I+ ++ +I L+ + S +++ + L +++ L Sbjct: 1077 LTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQAL 1126 Score = 31.2 bits (69), Expect = 4.0 Identities = 28/115 (24%), Positives = 52/115 (45%), Gaps = 4/115 (3%) Query: 637 ENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQE-NIKF 695 EN L + E ++ +E +E + + E ++ KEEL++ + N + Sbjct: 418 ENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRL 477 Query: 696 ENSISRLTEDKIL---LENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHND 747 E + L E+ L +E+ +R +E E+ L+ + QR+ +DK N ND Sbjct: 478 EKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLEND 532 >gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1 [Homo sapiens] Length = 3259 Score = 88.6 bits (218), Expect = 2e-17 Identities = 140/654 (21%), Positives = 268/654 (40%), Gaps = 88/654 (13%) Query: 109 LSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLP 168 L S++S +S+ + + +ED L ++L S+ I +E + K Y L Sbjct: 1560 LENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILL 1619 Query: 169 TAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNE 228 + NV ++A E + + +++Q K+EL G++ T E Sbjct: 1620 QSYENVSNEA--------------------ERIQHVVEAVRQEKQELY----GKLRST-E 1654 Query: 229 LQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPF 288 +T+ + + + +M + + F K K ++I ELE +L Sbjct: 1655 ANKKETEKQL-QEAEQEMEEMKEKMRKFAKS-----------KQQKILELEEENDRL--- 1699 Query: 289 RETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFL 348 + VH K + + K E KF S +S Sbjct: 1700 -----RAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQS-----LMSEK 1749 Query: 349 DQTKHEMKDKERQ-PFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKK 407 D E++D + Q V + + + EK +VTE+ Q + +E + Sbjct: 1750 DSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGT---QSIPGETEEQDSLSMS 1806 Query: 408 VMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKEC 467 SE++ P + S ++ Y +Q+ L E + ++ + K +E+S+ Sbjct: 1807 TRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTL 1866 Query: 468 LKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQL-----KSKEHKTQSDMAI 522 E ++S+ + G+ K L+E+ +++L QQ+ E L ++ ++E K + + Sbjct: 1867 ENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERL 1926 Query: 523 VN-------NENNRMSIEMEAMKTNILLIQDEKEM------LEKKTHQLLKEKSSLGNEL 569 +N + N +A N LL + K + LE++ QL+KEK+ + +E+ Sbjct: 1927 MNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEI 1986 Query: 570 KESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLE---TTLQESTAARQIMEREIE 626 ++ LE IQ +KE K+ + L ++++ + E L+ QE +A + + +E Sbjct: 1987 RKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALE 2046 Query: 627 NIQTYQ----STAEENFLQEI---KNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQ 679 +QT +EN Q + K A++E + +K L + E + ++ K + Q Sbjct: 2047 FVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQ 2106 Query: 680 ILKEELKKHSQENIKFENSISRL--TEDKILLENYVRSIENERDTLEFEMRHLQ 731 KE +K SQ K E+ RL E+K L E ++++ + D L E HL+ Sbjct: 2107 SNKESVK--SQMKQKDEDLERRLEQAEEKHLKEK--KNMQEKLDALRREKVHLE 2156 Score = 83.2 bits (204), Expect = 9e-16 Identities = 140/714 (19%), Positives = 280/714 (39%), Gaps = 88/714 (12%) Query: 71 MQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSV--NVPSQIH 128 M+TL + + + + E + ME + ++L S ++ LS + V L + NV Q + Sbjct: 1714 METLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLS-EEVQDLKHQIEGNVSKQAN 1772 Query: 129 SEDTLTL--RTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKS 186 E T +T+ + I +E D L PT +V S Sbjct: 1773 LEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTR-----PTCSESVPSAKSA----NP 1823 Query: 187 KITVPFLKH----GFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNG 242 ++ F H + + +D + I ++EE QK+ + L NE TL + ++G Sbjct: 1824 AVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQIST-KDG 1882 Query: 243 KYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEA------LVKKLLPFRETVSKFH 296 + M KMN + ++ + L+ K K +E E L+ +L ++ + Sbjct: 1883 ELKMLQEEVTKMNLLNQQ-IQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNY- 1940 Query: 297 VHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMK 356 C+ ++ +++ KNE E+ K +++L+ + L + K +++ Sbjct: 1941 ------CQDVTDAQI----KNELLESEMKNLKKCVSELEEEKQQ-------LVKEKTKVE 1983 Query: 357 DKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENL 416 + R+ +L K E S + E K Q ++ K+ ++ Q+K+ LE Sbjct: 1984 SEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVK 2043 Query: 417 NLK----SKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFK 472 L+ K L T ++L Q VE +K L K + S+ + LK K Sbjct: 2044 ALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKK 2103 Query: 473 KIISKYNVLQGQNKT-----------LEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMA 521 ++ S ++ Q K EEK+++ EK+ M E LD L+ ++ + + Sbjct: 2104 ELQSNKESVKSQMKQKDEDLERRLEQAEEKHLK---EKKNMQEKLDALRREKVHLEETIG 2160 Query: 522 IVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEI---IQ 578 + N+ E++ ++ N+ + K L ++ + +E K+ + + IQ Sbjct: 2161 EIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQ 2220 Query: 579 LKEKERLAKTE-----QETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQS 633 KE+E K + ++ L Q+ +++ K+N+ + + E++ Q Sbjct: 2221 SKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCD 2280 Query: 634 TAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENI 693 T + + + + +Y +S +E+ K L+ ELK + Sbjct: 2281 TLQGENKELLSQLEETRHLYHSSQNELAK------------------LESELKSLKDQLT 2322 Query: 694 KFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHND 747 NS+ + E K LE +R E + +F L+ + + + H + Sbjct: 2323 DLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEE 2376 Score = 72.8 bits (177), Expect = 1e-12 Identities = 167/867 (19%), Positives = 353/867 (40%), Gaps = 173/867 (19%) Query: 27 SEGVKESGCSDTE-YGCIAESENQIQPQSALKVLQQQL---ESFQALRMQTLQNVSMPTE 82 SE S C + E Y SE +++ Q K L+++L E FQAL Q Q + T Sbjct: 1047 SEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKT- 1105 Query: 83 NQEENLSMEKSHHFED-SKTLHSVEEKLSGDSVNSLPQSVNVP-----SQIH-----SED 131 NQ + L E S + K + S + GDSV + ++V + S H E Sbjct: 1106 NQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEK 1165 Query: 132 TLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVP 191 L L + L + + ILK R L + Q D D +++ Sbjct: 1166 ILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLRE---ELKQQKD----DYNRLQEQ 1218 Query: 192 FLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHR-----NGKYDM 246 F + + ++I ++Q++ ++++S DG++ T++ ++ + P + ++ Sbjct: 1219 FDEQS--KENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHT 1276 Query: 247 SPI-----------HQDKMNFIKEENLDGNLNEDIK-------------SKRISELEALV 282 P+ H + + ++ + +K S SEL Sbjct: 1277 QPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKS 1336 Query: 283 KKLLPFRETVSK--------------FHVHFCRKCKKLSKSEM------HRGKKNEKNNK 322 +++ +E ++K VH +KL S++ H + K ++ Sbjct: 1337 EEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDE 1396 Query: 323 EIPITGKNITDLKFHS--------RVPRYTLSFLDQ--------TKHEMKDKERQPFLVK 366 + K D+ + S + + ++Q T+ EM+ KE +K Sbjct: 1397 LQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDE-RIK 1455 Query: 367 QGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLI 426 Q + E K + E+ AK Q +Q L+ ++ +K+ ++ EN +L+ ++ Sbjct: 1456 QLQV-ELCEMKQKPEEIGEESRAK-QQIQRKLQAALISRKEALK---ENKSLQEELSLAR 1510 Query: 427 FTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNK 486 T + L + + E Q+ +EK T+ +L+ +E + + E + + + L + Sbjct: 1511 GTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCE 1570 Query: 487 TLEEKNIQLSLEKQQMMEALDQLKS-----------KEHKTQSDMAIVNNENNRMSIEME 535 +L+ L+ +K+++++ ++ LKS K + Q + I+ +S E E Sbjct: 1571 SLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAE 1630 Query: 536 AMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKER-LAKTEQETLL 594 ++ + ++ EK+ L K K +L+E++ E+ ++KEK R AK++Q+ +L Sbjct: 1631 RIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKIL 1690 Query: 595 QIIETVKDEKLN-------------LETTLQESTAARQIMER---EIENI-QTYQS--TA 635 ++ E ++++L +ET L + + ++ +ER E E + + +QS + Sbjct: 1691 ELEE--ENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSE 1748 Query: 636 EENFLQEIKNAK--------------------SEASIYKNSLSEIGKECEMLSKMVMET- 674 +++ +E+++ K ++ ++ + I E E + M T Sbjct: 1749 KDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTR 1808 Query: 675 ----------KTDNQILKEELKKHSQEN------IKFENSISRLTEDKILLENYVRSIEN 718 K+ N + ++ H + N + + I+ L E+K + + +++EN Sbjct: 1809 PTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLEN 1868 Query: 719 ERDTL-------EFEMRHLQREYLSLS 738 E++TL + E++ LQ E ++ Sbjct: 1869 EKNTLLSQISTKDGELKMLQEEVTKMN 1895 Score = 72.4 bits (176), Expect = 2e-12 Identities = 167/848 (19%), Positives = 337/848 (39%), Gaps = 151/848 (17%) Query: 4 EKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQQL 63 E E+D+++ L++ LN S G + C D A+ +N++ +S +K L++ + Sbjct: 1913 ETAEEEKDDLEERLMNQLAELNGSIG---NYCQDVTD---AQIKNELL-ESEMKNLKKCV 1965 Query: 64 ESFQALRMQTL-QNVSMPTENQEENLSM---------EKSHHFEDSKTLHSVEEKLSG-- 111 + + Q + + + +E ++E L KSH E + L ++++ Sbjct: 1966 SELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQ 2025 Query: 112 -------DSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFY 164 + +++L ++V + +E L + +NL+ + +++ Sbjct: 2026 KDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELAS------ 2079 Query: 165 RFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHD---- 220 + S+A V+ D K LK N + + +KQ E+L++ + Sbjct: 2080 --FKVLLDDTQSEAARVLADNLK-----LKKELQSNKESVKSQMKQKDEDLERRLEQAEE 2132 Query: 221 ---------------------------GEVALT-----NELQTLQTDPD--VHRNGKY-- 244 GE+ +T E+Q LQ + D V + + Sbjct: 2133 KHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTK 2192 Query: 245 DMSPIHQDKMNFIKE-ENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKC 303 MS + D+ I E + + ++ I+SK E+ ++ + + +H Sbjct: 2193 SMSSLQDDRDRVIDEAKKWERKFSDAIQSKE-EEIRLKEDNCSVLKDQLRQMSIHMEELK 2251 Query: 304 KKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKH-------EMK 356 +S+ E + K E+ + K L+ ++ LS L++T+H E+ Sbjct: 2252 INISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKE---LLSQLEETRHLYHSSQNELA 2308 Query: 357 DKERQPFLVKQ------GSIISENEKTSKVNSVTEQCVAKIQ---YLQNYLKESVQIQKK 407 E + +K S+ E+ + + Q A IQ + L+ +Q ++ Sbjct: 2309 KLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRE 2368 Query: 408 VMELESENLNLKS-KMKPLIFTTQSLIQKV-----ETYEKQLKNLVEEKSTIQSKLSKTE 461 + E +N+K K+ L+ + IQ + ++K++K L ++ LS+ E Sbjct: 2369 LTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKEL-------ENLLSQEE 2421 Query: 462 EYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMA 521 E + +E KK + K N L KT++++NIQ + ++++ L++ + D Sbjct: 2422 EENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQ 2481 Query: 522 IVNNENNRMSIEMEAMKTNILLIQD---EKEMLEKKTHQLLKEKSSLGNELKESQLEIIQ 578 + E +SI +E + LIQ+ E L+++ L L +E + E+IQ Sbjct: 2482 QL--EERHLSIILEKDQ----LIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQ 2535 Query: 579 LKE--------KERLAKTEQETLLQIIETVKDEKLNLETTLQESTAA------------- 617 +E K+ K E LQ + ++++ LE L+ES A Sbjct: 2536 YREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQE 2595 Query: 618 -RQIMEREIENIQT--YQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMET 674 +Q + +EIE+++ Q T + LQE + +Y L +E LS + + Sbjct: 2596 EKQDLSKEIESLKVSISQLTRQVTALQE----EGTLGLYHAQLKVKEEEVHRLSALFSSS 2651 Query: 675 KTDNQILKEELKKHSQENIKFENSI-SRLTEDKILLENYVRSIENERDTLEFEMRHLQRE 733 + L+EEL +E K I +L ++ L + + NE +T E + L R+ Sbjct: 2652 QKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARD 2711 Query: 734 YLSLSDKI 741 + + K+ Sbjct: 2712 LVEMEQKL 2719 Score = 71.6 bits (174), Expect = 3e-12 Identities = 116/614 (18%), Positives = 256/614 (41%), Gaps = 84/614 (13%) Query: 199 ENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIK 258 + L D+ +S+++ KE+ + + +G + Q + D+ +N K+ + D Sbjct: 2319 DQLTDLSNSLEKCKEQ-KGNLEGIIR--------QQEADI-QNSKFSYEQLETDLQ---A 2365 Query: 259 EENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKN- 317 L L+E+I K + L K + +++ ++ K+L ++N Sbjct: 2366 SRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENI 2425 Query: 318 ---EKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISEN 374 E+N K + T + + LK + + LD M + + G Sbjct: 2426 VLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIV-GDYQQLE 2484 Query: 375 EKTSKVNSVTEQCVAKIQYLQNYLKESVQ-IQKKVMELESENLNLKSKMKPLIFTTQSLI 433 E+ + +Q + + N LKE ++ ++ + +L SEN L ++ LI + L Sbjct: 2485 ERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAE---LIQYREDLN 2541 Query: 434 QKVETYEKQLKNLVE----EKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLE 489 Q + + Q K L+E + +++K +K EE KE + + + +N LQ + + L Sbjct: 2542 QVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLS 2601 Query: 490 EKNIQLSLEKQQMMEALD-------------QLKSKEHKTQSDMAIVNNENNRMS----- 531 ++ L + Q+ + QLK KE + A+ ++ R++ Sbjct: 2602 KEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEE 2661 Query: 532 ---IEMEAMKT-----------------NILLIQDEKEMLEKKTHQLLKEKSSLGNEL-- 569 ++ EA K + ++++E E E++ +L ++ + +L Sbjct: 2662 LVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLM 2721 Query: 570 --KESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQ--IMEREI 625 KE++ Q++ R + Q + E + + K + +L+E ++ ++ RE Sbjct: 2722 VTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRER 2781 Query: 626 ENIQTY----QSTAEENFLQEIKN------AKSEASIYKNS-LSEIGKECEMLSKMVMET 674 + + + ++ EEN L ++ +K E ++ +S L + + + SK + Sbjct: 2782 DALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASL 2841 Query: 675 KTDNQILKEELKKHSQENIKFENSISRLTEDKI---LLENYVRSIENERDTLEFEMRHLQ 731 + + L EL+K + + S ++ + L+ + S++N+RD L E+++LQ Sbjct: 2842 QNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQ 2901 Query: 732 REYLSLSDKICNQH 745 ++YL ++ +I H Sbjct: 2902 QQYLQINQEITELH 2915 Score = 67.8 bits (164), Expect = 4e-11 Identities = 114/584 (19%), Positives = 241/584 (41%), Gaps = 59/584 (10%) Query: 226 TNELQTLQTDPDVHRNGKYDMSPIHQDKMN--FIKEENLDGNLNEDIKSKRIS---ELEA 280 T++ DP++H+ + + Q+ + E L L + I+ K + + EA Sbjct: 22 TDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEA 81 Query: 281 LVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRV 340 L ++ + K +H K L+K + + + +P ++ L H + Sbjct: 82 LQEERKAADNKIKKLKLHAKAKLTSLNK---YIEEMKAQGGTVLPTEPQSEEQLSKHDKS 138 Query: 341 PRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKE 400 +++ KH++++KE ++ ++ E+ ++ ++ E+ V Q LQ + Sbjct: 139 STEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEF 198 Query: 401 SVQIQKKVMELESENLNLK-SKMKPLIFTTQ--------------------------SLI 433 +Q ++ + ++E + + K F TQ L Sbjct: 199 ISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQ 258 Query: 434 QKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNI 493 +K+E +E+ L + +Q +L+ E+ ++ ++ +++ +++N L+ +T E + Sbjct: 259 RKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVET-EREES 317 Query: 494 QLSLEKQQMMEALDQLKSKEHKTQSDM-AIVNNENNRMSIEMEAMKTNILLIQDEKEMLE 552 ++ LEK ++ A + K H Q +M ++ + E L Q K +E Sbjct: 318 KILLEKMELEVA--ERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEME 375 Query: 553 KKTHQLL------KEKSSLGNELKESQLEIIQLKEKERL--AKTEQETLLQIIETVKD-- 602 +KT +L +E S + LK+ +++Q K ++ + A+T Q+ Q+ + K+ Sbjct: 376 EKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEIS 435 Query: 603 EKLNLETTLQESTAARQIMEREIENIQTYQSTAEENF------LQEIKNAKSEASIYKNS 656 + LN LQ+ A Q ++ N T Q+ EEN + E++N K + Sbjct: 436 QFLN-RLPLQQHETASQTSFPDVYNEGT-QAVTEENIASLQKRVVELENEKGALLLSSIE 493 Query: 657 LSEIGKECEMLSKMVMETKTDNQI--LKEELKKHSQENIKFENSISRLTEDKILLENYVR 714 L E+ E E LS + + N+ E+ + S +I + S S + +LEN Sbjct: 494 LEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFS 553 Query: 715 SIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRRE 758 E L EM+ Q E L ++ + + + + ++E Sbjct: 554 QKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKE 597 Score = 62.0 bits (149), Expect = 2e-09 Identities = 131/634 (20%), Positives = 246/634 (38%), Gaps = 122/634 (19%) Query: 208 IKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQ-------DKMNFIKEE 260 IK +KE+L E A +++ + +MSP Q + + +K+E Sbjct: 928 IKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKE 987 Query: 261 NLDGN-------LNEDIKSKRISELEALV-------KKLLPFRETV------SKFHVHFC 300 N +N +R+S LE + KK +P ET K + + Sbjct: 988 NEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYS 1047 Query: 301 RKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKER 360 KC E+ K + KE+ + DL+ + + Q ++DK Sbjct: 1048 EKCVTSKCQEIEIYLKQTISEKEVELQHIR-KDLEEKLAAEEQFQALVKQMNQTLQDKTN 1106 Query: 361 QPFLVKQGSIISENEK------TSKVNSVTEQCVAKIQYLQNYLKESV------------ 402 Q L++ + ISEN+ TS ++ VA + KE+V Sbjct: 1107 QIDLLQ--AEISENQAIIQKLITSNTDASDGDSVALV-------KETVVISPPCTGSSEH 1157 Query: 403 ---QIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSK 459 ++++K++ LE E L+ K++ + + +++++K + E+ L+ EE + ++ Sbjct: 1158 WKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLR---EELKQQKDDYNR 1214 Query: 460 TEEYSKECLKEFKKIISKYNVLQGQN----------------------------KTLEEK 491 +E E KE + I + LQ Q K E+ Sbjct: 1215 LQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQH 1274 Query: 492 NIQLSLEKQ----------------------QMMEALDQLKSKEHKTQSDMAIVNNENNR 529 + Q LE Q+ L ++++++ + + ++ +E + Sbjct: 1275 HTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTK 1334 Query: 530 MSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTE 589 S E+ ++ I E E L+ +H+ SL +L+ SQL+I L+ L + + Sbjct: 1335 KSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLREL-QPK 1393 Query: 590 QETLLQIIETVKDEKLNLETTLQESTAA-----RQIMERE--IENIQTYQSTAEENFLQE 642 + L ++I +++ L L E AA +I+E+E I+ + T + + Sbjct: 1394 LDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDER 1453 Query: 643 IKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELK--KHSQENIKF-ENSI 699 IK + E K EIG+E ++ + + KE LK K QE + +I Sbjct: 1454 IKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTI 1513 Query: 700 SRLTEDKILLENYVRSIENERDTLEFEMRHLQRE 733 RLT+ +E+ V + E+DT+ + LQ E Sbjct: 1514 ERLTKSLADVESQVSAQNKEKDTVLGRLALLQEE 1547 Score = 60.5 bits (145), Expect = 6e-09 Identities = 143/787 (18%), Positives = 312/787 (39%), Gaps = 108/787 (13%) Query: 44 AESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHH--FEDSKT 101 AE NQI L QQL+ +A TL+N ++ TE +E + +EK E + Sbjct: 285 AEQRNQI--------LSQQLQQMEA-EHNTLRN-TVETEREESKILLEKMELEVAERKLS 334 Query: 102 LHSVEEKL---------SGDSVNSLPQSVNVPSQIHSEDT-------LTLRTSTDNLSSN 145 H+++E++ +G + L + Q H + L+L+ + L S Sbjct: 335 FHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSA 394 Query: 146 IIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKH--------GF 197 +NS +L++ N + Q + + KSK FL Sbjct: 395 CDALKDQNSKLLQDKNE----QAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETAS 450 Query: 198 CENLDDICHSIKQM--KEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMN 255 + D+ + Q +E + V L NE L K + + ++ Sbjct: 451 QTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKL-SSQIT 509 Query: 256 FIKEENLDGNLNE--------DIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLS 307 ++ +N G + DI +KR S E + +L T S+ H ++ Sbjct: 510 LLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVL--ENTFSQKHKELSVLLLEMK 567 Query: 308 KSEMH--------RGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEM---- 355 +++ +GK+ E+ + E+ + K + ++ P FL+ T + Sbjct: 568 EAQEEIAFLKLQLQGKRAEEADHEV-LDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMP 626 Query: 356 KDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESEN 415 ++ P + K+ + +TS+ S+ + V L++ ++ + V ++ + Sbjct: 627 NEESSLPAVEKEQASTEHQSRTSEEISLNDAGVE----LKSTKQDGDKSLSAVPDIGQCH 682 Query: 416 LNLKSKMKPLIFTTQSLIQKV-ETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKI 474 + ++K I + K E YEK L +E S + + + ++ + F + Sbjct: 683 QDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTAL 742 Query: 475 ISKYNVLQGQNKTL--------EEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNE 526 + + L Q K L + K ++++L + + LD H ++ + Sbjct: 743 SEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDN-----LLTEQ 797 Query: 527 NNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLA 586 + +SIE ++ I ++Q+E + ++ + + SL ++L+ + E+++ E+ R Sbjct: 798 IHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHI 857 Query: 587 KTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQ--EIK 644 ++ E L Q + + LE T + Q++ + +++T Q T EE Q EI Sbjct: 858 SSKVEELSQAL-----SQKELEITKMD-----QLLLEKKRDVETLQQTIEEKDQQVTEIS 907 Query: 645 NAKSEASIYKNSLS-EIGKECEMLSKMVMETKTDNQILKEELKKHSQ------ENIKFEN 697 + +E + N +G E + L + + + KE++++ ++ +N + Sbjct: 908 FSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMS 967 Query: 698 SISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYL-----SLSDKICNQHNDPSKTT 752 +++++++ E + ENE+ + + + R+ L L +++ N ++ K Sbjct: 968 PAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEI 1027 Query: 753 YISRREK 759 +S E+ Sbjct: 1028 PLSETER 1034 Score = 53.1 bits (126), Expect = 1e-06 Identities = 116/546 (21%), Positives = 218/546 (39%), Gaps = 125/546 (22%) Query: 209 KQMKEELQKSHDGEVALTN---ELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGN 265 +Q E Q E++L + EL++ + D D + D+ HQD++ +K + L+ Sbjct: 638 EQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELE 697 Query: 266 LNEDIKSKRISE--LEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKE 323 LN K++ I E L+ K++ + + +F KKN NN Sbjct: 698 LNFH-KAQEIYEKNLDEKAKEISNLNQLIEEF-------------------KKNADNNSS 737 Query: 324 IPITGKNITDLKFHSRVPRYTL-----SFLDQTKHEMKDKERQPFLVKQGSIISENEKTS 378 T + + S+V ++ + + Q + + + ERQ L + +N T Sbjct: 738 A-FTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTE 796 Query: 379 KVNSVTEQCVAK---IQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQK 435 +++S++ + +K I+ LQN L + VQ+Q S+ LI + QS +Q Sbjct: 797 QIHSLSIEAKSKDVKIEVLQNEL-DDVQLQF-------------SEQSTLIRSLQSQLQN 842 Query: 436 VETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQL 495 E+ ++E ++ SK EE S + L + + I+K + QL Sbjct: 843 KES------EVLEGAERVRHISSKVEELS-QALSQKELEITKMD--------------QL 881 Query: 496 SLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKT 555 LEK++ +E L Q ++ + ++++ E K Sbjct: 882 LLEKKRDVETLQQTIEEKDQQVTEISFSMTE---------------------------KM 914 Query: 556 HQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQEST 615 QL +EK SLG E+K LKE+ L +E + +E + L+ E + Sbjct: 915 VQLNEEKFSLGVEIKT-------LKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMS 967 Query: 616 AARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETK 675 A QI + E+++ + +EN E + K +A++ E+L + V + Sbjct: 968 PAGQISKEELQH--EFDLLKKEN---EQRKRKLQAALINRK--------ELLQR-VSRLE 1013 Query: 676 TDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRS--------IENERDTLEFEM 727 + LK+E KK + + E+K E V S ++ E E+ Sbjct: 1014 EELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVEL 1073 Query: 728 RHLQRE 733 +H++++ Sbjct: 1074 QHIRKD 1079 Score = 48.5 bits (114), Expect = 2e-05 Identities = 75/383 (19%), Positives = 161/383 (42%), Gaps = 62/383 (16%) Query: 447 VEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNV--------LQGQNKTLEEKNIQLSLE 498 +E +T Q + + Y+++ + E K II + +V LQ + K + K +L L Sbjct: 40 MEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLH 99 Query: 499 KQQMMEAL----DQLKSK-----EHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKE 549 + + +L +++K++ + QS+ + ++ + EME K L Q+++E Sbjct: 100 AKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKL-QEKEE 158 Query: 550 MLEKKTHQLLK----EKSSLGNELKESQLEIIQLKEKE--------RLAKTEQETLLQII 597 ++ QL + + + E++E + QL+EKE +L++T+ E Q + Sbjct: 159 LISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQV 218 Query: 598 ETVKDEKLNLETTLQESTAARQIMEREIEN-----IQTYQSTAEEN-------------F 639 KD + + L E + + + ++E ++ Q EE+ Sbjct: 219 VREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLL 278 Query: 640 LQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELK-KHSQENIKFENS 698 QE+ A+ I L ++ E L V + +++IL E+++ + ++ + F N Sbjct: 279 QQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNL 338 Query: 699 ISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRRE 758 + LLE + ++ + + + L+ Y +L K ++ KT++I + Sbjct: 339 QEEMHH---LLEQFEQAGQAQAE--------LESRYSALEQK--HKAEMEEKTSHILSLQ 385 Query: 759 KFHFDNYTHEDTSSPQSRPLASD 781 K + + D Q+ L D Sbjct: 386 KTGQELQSACDALKDQNSKLLQD 408 Score = 36.2 bits (82), Expect = 0.12 Identities = 97/546 (17%), Positives = 206/546 (37%), Gaps = 60/546 (10%) Query: 43 IAESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTL 102 I +E + + ++ + +E Q L M T +N + + Q SM + D Sbjct: 2693 IMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANE 2752 Query: 103 HSVEEKLSGD-SVNSLPQSVNVPSQIHSEDTLTLRT--STDNLSSNIIIHPSENSDILKN 159 E K D S+ L Q D L T S ++ N + H + + L + Sbjct: 2753 ELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLS 2812 Query: 160 YNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSH 219 + L + + +Q + F + + + + + EL+K Sbjct: 2813 KDEQLLHLSSQLEDSYNQVQS----------------FSKAMASLQNERDHLWNELEKFR 2856 Query: 220 DGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIK--SKRISE 277 E T P ++ K MS + D+ +KE NL + ++ I+E Sbjct: 2857 KSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELK---NLQQQYLQINQEITE 2913 Query: 278 LEALVKKLLPFRETVSKFHV--HFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLK 335 L L +L +++ F + R+ + E+H+ + EK++ EI Sbjct: 2914 LHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQ-LRMEKSSWEI----------- 2961 Query: 336 FHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQ 395 H R + +Q + DK++Q L ++I E +S ++ K+QY + Sbjct: 2962 -HERRMK------EQYLMAISDKDQQ--LSHLQNLIRELRSSS-----SQTQPLKVQYQR 3007 Query: 396 NYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQS 455 E+ L E L++++ + +++ L+EEK+T+ Sbjct: 3008 QASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSI 3067 Query: 456 KLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHK 515 +L T + +E + + +++ VL+ Q + L+ + + + Q K+ H+ Sbjct: 3068 QLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNI-----DVAPGAPQEKNGVHR 3122 Query: 516 TQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLE 575 +SD + S + + + + +++LE++ Q + +++L + E Q+ Sbjct: 3123 -KSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENAL--SVAEEQIR 3179 Query: 576 IIQLKE 581 ++ E Sbjct: 3180 RLEHSE 3185 >gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] Length = 1960 Score = 87.8 bits (216), Expect = 4e-17 Identities = 95/411 (23%), Positives = 198/411 (48%), Gaps = 42/411 (10%) Query: 348 LDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKK 407 + + + EM KE + V++ + +EN T ++ ++ Q +A+ LQ L+ ++ + Sbjct: 840 VSRQEEEMMAKEEELVKVREKQLAAENRLT-EMETLQSQLMAEKLQLQEQLQAETELCAE 898 Query: 408 VMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKEC 467 EL + L +K + L L +VE E++ ++L EK +Q + + EE +E Sbjct: 899 AEELRAR---LTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEE 955 Query: 468 LKEFKKII-------SKYNVLQGQNKTLEEKNIQLSLEKQ----QMMEALDQLKSKEHKT 516 +K+ +K L+ + LE++N +L+ EK+ ++ E L +E K+ Sbjct: 956 ESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKS 1015 Query: 517 QSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEI 576 +S +A + N++ M ++E + + +++ LEK +L + + L +++ E Q +I Sbjct: 1016 KS-LAKLKNKHEAMITDLE---ERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQI 1071 Query: 577 IQLKEKERLAKTEQE---TLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQS 633 +L K +LAK E+E L ++ E + + L+ ++E + ++ ++E+ + ++ Sbjct: 1072 AEL--KMQLAKKEEELQAALARVEEEAAQKNMALK-KIRELESQISELQEDLESERASRN 1128 Query: 634 TAEE---NFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELK---- 686 AE+ + +E++ K+E +++L + E+ SK E + L+EE K Sbjct: 1129 KAEKQKRDLGEELEALKTE---LEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEA 1185 Query: 687 -------KHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHL 730 KHSQ + + + K LE +++ENER L E++ L Sbjct: 1186 QIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVL 1236 Score = 73.2 bits (178), Expect = 9e-13 Identities = 119/590 (20%), Positives = 257/590 (43%), Gaps = 68/590 (11%) Query: 199 ENLDDICHS----IKQMKEELQKSHDGEVALTNELQTL--QTDPDVHRNGKYDMSPIHQD 252 + L++ICH +++ +E Q + + +Q L Q + + K + + + Sbjct: 911 QELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTE 970 Query: 253 -KMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPF------RETVSKFHVHFCRKCKK 305 K+ ++EE + + ED K E + L ++ F E SK K + Sbjct: 971 AKLKKLEEEQI---ILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEA 1027 Query: 306 LSKSEMHRGKKNEKNNKEIPITGKNI----TDLKFHSRVPRYTLSFLDQTKHEMKDKERQ 361 + R ++ EK +E+ T + + TDL + ++ L + + K++E Q Sbjct: 1028 MITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAEL-KMQLAKKEEELQ 1086 Query: 362 PFLVK-QGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKS 420 L + + +N K+ + Q + L++ + +K+ +L E LK+ Sbjct: 1087 AALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKT 1146 Query: 421 KMKPLIFTT---QSLIQKVETYEKQLKNLVEEKST--------IQSKLSKTEEYSKECLK 469 +++ + +T Q L K E LK +EE++ ++ K S+ E E L+ Sbjct: 1147 ELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLE 1206 Query: 470 EFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQS---DMAIVNNE 526 + K++ + L+ +TLE + +L+ E + +++ + K K ++ ++ + NE Sbjct: 1207 QTKRVKAN---LEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNE 1263 Query: 527 NNRMSIEMEAMKTNILLIQDEKEML----EKKTHQLLKEKSSLGNELKESQLEIIQLKEK 582 R+ E+ T + + D L + K+ +L K+ S+L ++L+++Q E++Q + + Sbjct: 1264 GERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQ-ELLQEENR 1322 Query: 583 ERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENF--- 639 ++L+ + + ++ V+DEK + L+E A+ +E++I + + ++ Sbjct: 1323 QKLSLSTK------LKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDS 1376 Query: 640 ---LQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKT------DNQILKEELKKHSQ 690 L+ + K + LS+ +E + +TKT D+ ++ + ++ S Sbjct: 1377 VGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSA 1436 Query: 691 ENI--KFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLS 738 N+ K + L E+K + Y ERD E E R + + LSL+ Sbjct: 1437 CNLEKKQKKFDQLLAEEKTISAKYA----EERDRAEAEAREKETKALSLA 1482 Score = 60.8 bits (146), Expect = 5e-09 Identities = 147/738 (19%), Positives = 298/738 (40%), Gaps = 94/738 (12%) Query: 55 ALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSV 114 A++ L +QLE + ++ L+ EN+ L+ E + +K+ + Sbjct: 1197 AVEELAEQLEQTKRVKAN-LEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQ-L 1254 Query: 115 NSLPQSVNVPSQIHSE--DTLT-LRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAP 171 L N ++ +E D +T L+ DN++ + S++S + K+++ L Sbjct: 1255 QELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQ 1314 Query: 172 PNVMSQADTVILDKSKIT-VPFLKHGFCENLDDICHSIKQMKEELQKSH----DGEVALT 226 + + + +K+ V K+ F E L++ + +++++ H D + + Sbjct: 1315 ELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKME 1374 Query: 227 NELQTLQTDPDVHRNGKYDMSPIHQ---------DKMNFIK---EENLDGNLNE-DIKSK 273 + + L+T +V R + D+ + Q DK+ K ++ LD L + D + + Sbjct: 1375 DSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQ 1434 Query: 274 RISELEALVKK---LLPFRETVSKFHVHFC---------RKCKKLS-----------KSE 310 LE KK LL +T+S + ++ K LS K+E Sbjct: 1435 SACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAE 1494 Query: 311 MHRGKKNEKNNKEIPIT-----GKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLV 365 + R K + E ++ GK++ +L+ R L+Q EMK + + Sbjct: 1495 LERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRA-------LEQQVEEMKTQLEELEDE 1547 Query: 366 KQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESV-QIQKKVMELESENLNLKSKMKP 424 Q + ++ + ++ Q +Q +E Q+ ++V E+E+E + + + Sbjct: 1548 LQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSM 1607 Query: 425 LIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQ 484 + + L ++ E + + + + +L K + K+C++E + + Q Sbjct: 1608 AVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQ 1667 Query: 485 NKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLI 544 K E+K + E Q+ E L + + + Q E + ++ E+ L Sbjct: 1668 AKENEKKLKSMEAEMIQLQEELAAAERAKRQAQ-------QERDELADEIANSSGKGALA 1720 Query: 545 QDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEK 604 +EK LE + QL +E E ++ E+I +RL K LQI + D Sbjct: 1721 LEEKRRLEARIAQLEEEL-----EEEQGNTELI----NDRLKKAN----LQIDQINTD-- 1765 Query: 605 LNLETT-LQESTAARQIMEREIE----NIQTYQSTAEENFLQEIKNAKSEASIYKNSLSE 659 LNLE + Q++ ARQ +ER+ + +Q + T + + I +++ + + L Sbjct: 1766 LNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDN 1825 Query: 660 IGKECEMLSKMVMET--KTDNQILKEELKKHSQENIK--FENSISRLTEDKILLENYVRS 715 KE + K V T K + +L+ + ++ + E K + + +RL + L+ + Sbjct: 1826 ETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQ----LKRQLEE 1881 Query: 716 IENERDTLEFEMRHLQRE 733 E E R LQRE Sbjct: 1882 AEEEAQRANASRRKLQRE 1899 Score = 47.8 bits (112), Expect = 4e-05 Identities = 111/627 (17%), Positives = 242/627 (38%), Gaps = 94/627 (14%) Query: 5 KQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESEN-QIQPQSALKVLQQQL 63 +Q EE+E L L++ + D+ GC+ +E + + Q L+ L Q+ Sbjct: 1343 EQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDS-VGCLETAEEVKRKLQKDLEGLSQRH 1401 Query: 64 ESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNV 123 E + L+ + + ++L ++ H + + L ++K S Sbjct: 1402 EE-KVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKY 1460 Query: 124 PSQIHSEDTLTLRTSTDNLS-SNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVI 182 + + T LS + + E L+ N +R T ++MS D V Sbjct: 1461 AEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFR---TEMEDLMSSKDDV- 1516 Query: 183 LDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNG 242 KS + K + ++++ ++++++ELQ + D ++ L LQ ++ + G Sbjct: 1517 -GKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQG 1575 Query: 243 KYDMSPIHQDKMNFIKE-ENLDGNLNEDIKSKRIS-----ELEALVKKLLPFRETVSKFH 296 + + S + K +++ ++ L ++ K + ++ +LE +K L ++ +K Sbjct: 1576 RDEQS--EEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNR 1633 Query: 297 VHFCRKCKKL----------------SKSE-MHRGKKNEKNNKEIPITGKNITD-LKFHS 338 ++ +KL S+ E + + K+NEK K + + + L Sbjct: 1634 DEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAE 1693 Query: 339 RVPRYTLSFLDQTKHEMKDKERQPFLV--------------------KQGSIISENEKTS 378 R R D+ E+ + + L +QG+ N++ Sbjct: 1694 RAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLK 1753 Query: 379 KVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQS------- 431 K N +Q + +++ +++ ++ +LE +N LK K++ + T +S Sbjct: 1754 KANLQIDQINTDLNLERSHAQKNENARQ---QLERQNKELKVKLQEMEGTVKSKYKASIT 1810 Query: 432 -LIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEE 490 L K+ E+QL N +E+ ++ +TE+ K+ L + + + + E+ Sbjct: 1811 ALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQ----------VDDERRNAEQ 1860 Query: 491 KNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEM 550 Q ++ + QL+ E + Q A +R ++ E ++D E Sbjct: 1861 YKDQADKASTRLKQLKRQLEEAEEEAQRANA------SRRKLQRE--------LEDATET 1906 Query: 551 LEKKTHQLLKEKSSLGNELKESQLEII 577 + +E SSL N+L+ L + Sbjct: 1907 ADAMN----REVSSLKNKLRRGDLPFV 1929 Score = 40.4 bits (93), Expect = 0.007 Identities = 38/168 (22%), Positives = 76/168 (45%), Gaps = 16/168 (9%) Query: 559 LKEKSSLGNELKESQLEIIQLKEKERLAK---TEQETLLQIIETVKDEKLNLETTLQEST 615 L + S E+ + E+++++EK+ A+ TE ETL + EKL L+ LQ T Sbjct: 837 LLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMA---EKLQLQEQLQAET 893 Query: 616 ----------AARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECE 665 A ++E+E I E + ++ ++E + ++ E+ ++ E Sbjct: 894 ELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLE 953 Query: 666 MLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYV 713 + + + + +LKK +E I E+ +L ++K LLE+ + Sbjct: 954 EEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRI 1001 Score = 30.8 bits (68), Expect = 5.2 Identities = 31/128 (24%), Positives = 53/128 (41%), Gaps = 9/128 (7%) Query: 641 QEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSIS 700 +E+ + + +N L+E+ E L +M K L+E+L+ ++ + E + Sbjct: 852 EELVKVREKQLAAENRLTEM----ETLQSQLMAEKLQ---LQEQLQAETELCAEAEELRA 904 Query: 701 RLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRREKF 760 RLT K LE +E + E +HLQ E + I Q + S R+K Sbjct: 905 RLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNI--QELEEQLEEEESARQKL 962 Query: 761 HFDNYTHE 768 + T E Sbjct: 963 QLEKVTTE 970 >gi|38044112 restin isoform b [Homo sapiens] Length = 1392 Score = 83.2 bits (204), Expect = 9e-16 Identities = 152/728 (20%), Positives = 309/728 (42%), Gaps = 103/728 (14%) Query: 62 QLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGD------SVN 115 +LE ALR+Q + + E+ + ++ S + + S++EKL + Sbjct: 468 ELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSL--LQEISSLQEKLEVTRTDHQREIT 525 Query: 116 SLPQSVNVPSQIHSEDTLTLRTSTDNLS-------SNIIIHPSENSDILKNYNNFYRFLP 168 SL + + H ++ L T+T+ LS S + ENSD++ + Sbjct: 526 SLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWK------- 578 Query: 169 TAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNE 228 S+ +T I + + LK F + L ++K +++K + +E Sbjct: 579 -------SKLETAIASHQQ-AMEELKVSFSKGLGTETAEFAELKTQIEKMR---LDYQHE 627 Query: 229 LQTLQTDPDVHRNGKY-DMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLP 287 ++ LQ D R +M + M IKE+ N E I+SK +A + L+ Sbjct: 628 IENLQNQQDSERAAHAKEMEALRAKLMKVIKEKE---NSLEAIRSKLD---KAEDQHLVE 681 Query: 288 FRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNN------KEIPITGKNITDLKFHSRVP 341 +T++K K+ + E+ + K NE+ ++ T + + DL + Sbjct: 682 MEDTLNKLQEAEI----KVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKAS 737 Query: 342 RYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVA---KIQYLQNYL 398 S + + + +++ E+Q ++ I +N ++SK +S+T + K+ LQ L Sbjct: 738 SEGKSEMKKLRQQLEAAEKQIKHLE----IEKNAESSKASSITRELQGRELKLTNLQENL 793 Query: 399 KESVQIQKKVMELESENLNLK---------SKMKPLIFTTQSLIQKVETYE---KQLKNL 446 E Q+ K+ +E E + L K S + + T L QK E + L+ L Sbjct: 794 SEVSQV-KETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKL 852 Query: 447 VEEKSTIQSKLSKTEEYSKECLKEFKKI---ISKYNVLQGQNKT-LEEKNIQLSLEKQQM 502 E + +++K + +E ++ +K +K+ I++ + G N + L + N +L L+++ + Sbjct: 853 RENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDV 912 Query: 503 MEA-LDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKE 561 E L K+ E+ + +I + + EA K + ++EK+ LE+K L K+ Sbjct: 913 EELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKH----EEEKKELERKLSDLEKK 968 Query: 562 KSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIE-TVKDEKLNLETTLQESTAARQI 620 + N+ +E + + + KT+ E +LQ ++ T+ D + L+ +E++ Q Sbjct: 969 METSHNQCQELKARYERATSE---TKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQ- 1024 Query: 621 MEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQI 680 E+E ++ A+ A A + ++ KE + +TK N Sbjct: 1025 ---ELEELRKQADKAK---------AAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAK 1072 Query: 681 LKEELKKHSQENIKFENSISR----LTEDKILLENYVRSIENERDTL---EFEMRHLQRE 733 L+ EL + N+K +++ LT + +E + + IE + ++ LQ E Sbjct: 1073 LQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEE 1132 Query: 734 YLSLSDKI 741 + L++++ Sbjct: 1133 NVKLAEEL 1140 Score = 68.2 bits (165), Expect = 3e-11 Identities = 147/768 (19%), Positives = 310/768 (40%), Gaps = 111/768 (14%) Query: 6 QHREEDEVDSVLLSASK----ILNSSEGVKESGCS-----DTEYGCIAESENQIQP---- 52 +H ++ D + L SK I + + ++E S TE AE + QI+ Sbjct: 564 EHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLD 623 Query: 53 -QSALKVLQQQLESFQALR---MQTLQNVSMPTENQEENL---------SMEKSHHFEDS 99 Q ++ LQ Q +S +A M+ L+ M ++EN E H E Sbjct: 624 YQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEME 683 Query: 100 KTLHSVEE-KLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHP--SENSDI 156 TL+ ++E ++ + L N +++ T L+ + + L + SE Sbjct: 684 DTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSE 743 Query: 157 LKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGF-CENLDDICHSIKQMKEEL 215 +K ++ + + S IT NL + + Q+KE L Sbjct: 744 MKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETL 803 Query: 216 QKSHDGEVALTNE--LQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSK 273 +K E+ + E + + V R+ + ++ +HQ KEE + L+ D++ Sbjct: 804 EK----ELQILKEKFAEASEEAVSVQRSMQETVNKLHQ------KEEQFN-MLSSDLEKL 852 Query: 274 R--ISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNI 331 R ++++EA ++ E + K ++ K + K N E+ + +++ Sbjct: 853 RENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDV 912 Query: 332 TDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTS----------KVN 381 +L+ SFL ++ +M K Q ++ + E EK K+ Sbjct: 913 EELQLKLTKANENASFLQKSIEDMTVKAEQS--QQEAAKKHEEEKKELERKLSDLEKKME 970 Query: 382 SVTEQCVA-KIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYE 440 + QC K +Y + + + ++ + L+ L+ + K+K L+Q++E Sbjct: 971 TSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELR 1030 Query: 441 KQLKNL-----VEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQ- 494 KQ E+ I +++K + + L++ K+ +K LQ + TL+E N++ Sbjct: 1031 KQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAK---LQNELDTLKENNLKN 1087 Query: 495 ----------LSLEKQQMME---ALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNI 541 L++E Q+M E ++ LK + ++ + EN +++ E+ + Sbjct: 1088 VEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRD-- 1145 Query: 542 LLIQDEKEMLEKKTHQLLKEKSSLGN----ELKESQLEIIQLKEKERLAKTEQETLLQII 597 E +HQ L+E+ S+ N E+K+ + + I+ ++E+ + + ++ + Sbjct: 1146 ----------EVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSAL 1195 Query: 598 ETVKDEKL----NLETTLQESTAARQIMEREIENIQTYQSTAE---ENFLQEIKNAKSEA 650 T KD +L N T L+ A+ + + ++ +++ + E +N ++K K + Sbjct: 1196 LTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQL 1255 Query: 651 SIYKNSLSEIGKECE--------MLSKMVMETKTDNQILKEELKKHSQ 690 S + E E L+ ++++ + NQ LK +++ S+ Sbjct: 1256 SSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1303 Score = 61.2 bits (147), Expect = 4e-09 Identities = 98/482 (20%), Positives = 199/482 (41%), Gaps = 80/482 (16%) Query: 342 RYTLSFLDQTKHEMKDKERQPFLVKQGSI---------ISENEKTSKVNSVTEQCVAKIQ 392 R + L+Q + E + E F V++ SI +SE + ++ V ++ Sbjct: 422 REKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVA 481 Query: 393 YLQNYLKE---------SVQIQKKVMELESE-NLNLKSKMKPLIFTTQSLIQKVETYEKQ 442 L+ L+ S+ + +++ L+ + + + + + + ET++K+ Sbjct: 482 ELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKE 541 Query: 443 LK-------NLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQL 495 +K L +E +++SKL + + + + +K + + + +EE + Sbjct: 542 IKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLE--TAIASHQQAMEELKVSF 599 Query: 496 SLEKQQMMEALDQLKSKEHKTQSDMA--IVNNENNRMSI------EMEAMKTNILLIQDE 547 S +LK++ K + D I N +N + S EMEA++ ++ + E Sbjct: 600 SKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKE 659 Query: 548 KE--------MLEKKTHQLLKEKSSLGNELKESQ-----LEIIQLKEKER---------- 584 KE L+K Q L E N+L+E++ LE++Q K E+ Sbjct: 660 KENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQ 719 Query: 585 LAKTEQETL-LQIIETVKDE-KLNLETTLQESTAA-RQIMEREIENIQTYQSTAEENFLQ 641 L TE++ L L + E K ++ Q+ AA +QI EIE + +S+ + + Sbjct: 720 LKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIE--KNAESSKASSITR 777 Query: 642 EIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISR 701 E++ + + + + +LSE+ + E L K + QILKE+ + S+E + + S+ Sbjct: 778 ELQGRELKLTNLQENLSEVSQVKETLEKEL-------QILKEKFAEASEEAVSVQRSMQE 830 Query: 702 LTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRREKFH 761 N + E + + L ++ L+ + K + D + I +EK Sbjct: 831 TV-------NKLHQKEEQFNMLSSDLEKLRENLADMEAKF--REKDEREEQLIKAKEKLE 881 Query: 762 FD 763 D Sbjct: 882 ND 883 Score = 53.1 bits (126), Expect = 1e-06 Identities = 114/599 (19%), Positives = 239/599 (39%), Gaps = 64/599 (10%) Query: 2 SPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQ 61 S K+ R++ E + +I ++E K S + G + N + S + +++ Sbjct: 742 SEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKE 801 Query: 62 QLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEK---LSGDSVNSLP 118 LE +Q L+ E EE +S+++S E LH EE+ LS D Sbjct: 802 TLEK----ELQILKEKF--AEASEEAVSVQRSMQ-ETVNKLHQKEEQFNMLSSDLEKLRE 854 Query: 119 QSVNVPSQIHSEDT-----LTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPN 173 ++ ++ +D + + +N + I+ +NS L N+ R Sbjct: 855 NLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEE 914 Query: 174 VMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVA-LTNELQTL 232 + + L K+ FL+ ++++D+ +Q ++E K H+ E L +L L Sbjct: 915 LQLK-----LTKANENASFLQ----KSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDL 965 Query: 233 QTDPDVHRNGKYDMSPIHQDKMNFIKE------ENLDGNL--NEDIKSKRISELEALVKK 284 + + N ++ ++ + K +NL L ED E L+++ Sbjct: 966 EKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQE 1025 Query: 285 LLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEI--PITGKNITDLKFHSRVPR 342 L R+ K K + ++ M ++ K E + T+ K + + Sbjct: 1026 LEELRKQADK------AKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDT 1079 Query: 343 YTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESV 402 + L + K KE L + + E K ++ ++ + K Q L +E+V Sbjct: 1080 LKENNLKNVEELNKSKE---LLTVENQKMEEFRK--EIETLKQAAAQKSQQLSALQEENV 1134 Query: 403 QIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEE 462 ++ +++ E + + + L++ + K +K+ EEK+++Q +S T Sbjct: 1135 KLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSA 1194 Query: 463 YSKECLKEFKKIISKYNVLQGQN----------KTLEEKNIQLSLE----KQQMMEALDQ 508 E E +K+ ++ VL+G+N +TLE ++L L+ + Q+ E Q Sbjct: 1195 LLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQ 1254 Query: 509 LKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGN 567 L S T + + + +++ + + I+ +Q + + L+ K +++ E + GN Sbjct: 1255 LSSSSGNTDTQ---ADEDERAQESQIDFLNSVIVDLQRKNQDLKMKV-EMMSEAALNGN 1309 >gi|4506751 restin isoform a [Homo sapiens] Length = 1427 Score = 83.2 bits (204), Expect = 9e-16 Identities = 152/728 (20%), Positives = 309/728 (42%), Gaps = 103/728 (14%) Query: 62 QLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGD------SVN 115 +LE ALR+Q + + E+ + ++ S + + S++EKL + Sbjct: 503 ELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSL--LQEISSLQEKLEVTRTDHQREIT 560 Query: 116 SLPQSVNVPSQIHSEDTLTLRTSTDNLS-------SNIIIHPSENSDILKNYNNFYRFLP 168 SL + + H ++ L T+T+ LS S + ENSD++ + Sbjct: 561 SLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWK------- 613 Query: 169 TAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNE 228 S+ +T I + + LK F + L ++K +++K + +E Sbjct: 614 -------SKLETAIASHQQ-AMEELKVSFSKGLGTETAEFAELKTQIEKMR---LDYQHE 662 Query: 229 LQTLQTDPDVHRNGKY-DMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLP 287 ++ LQ D R +M + M IKE+ N E I+SK +A + L+ Sbjct: 663 IENLQNQQDSERAAHAKEMEALRAKLMKVIKEKE---NSLEAIRSKLD---KAEDQHLVE 716 Query: 288 FRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNN------KEIPITGKNITDLKFHSRVP 341 +T++K K+ + E+ + K NE+ ++ T + + DL + Sbjct: 717 MEDTLNKLQEAEI----KVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKAS 772 Query: 342 RYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVA---KIQYLQNYL 398 S + + + +++ E+Q ++ I +N ++SK +S+T + K+ LQ L Sbjct: 773 SEGKSEMKKLRQQLEAAEKQIKHLE----IEKNAESSKASSITRELQGRELKLTNLQENL 828 Query: 399 KESVQIQKKVMELESENLNLK---------SKMKPLIFTTQSLIQKVETYE---KQLKNL 446 E Q+ K+ +E E + L K S + + T L QK E + L+ L Sbjct: 829 SEVSQV-KETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKL 887 Query: 447 VEEKSTIQSKLSKTEEYSKECLKEFKKI---ISKYNVLQGQNKT-LEEKNIQLSLEKQQM 502 E + +++K + +E ++ +K +K+ I++ + G N + L + N +L L+++ + Sbjct: 888 RENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDV 947 Query: 503 MEA-LDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKE 561 E L K+ E+ + +I + + EA K + ++EK+ LE+K L K+ Sbjct: 948 EELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKH----EEEKKELERKLSDLEKK 1003 Query: 562 KSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIE-TVKDEKLNLETTLQESTAARQI 620 + N+ +E + + + KT+ E +LQ ++ T+ D + L+ +E++ Q Sbjct: 1004 METSHNQCQELKARYERATSE---TKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQ- 1059 Query: 621 MEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQI 680 E+E ++ A+ A A + ++ KE + +TK N Sbjct: 1060 ---ELEELRKQADKAK---------AAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAK 1107 Query: 681 LKEELKKHSQENIKFENSISR----LTEDKILLENYVRSIENERDTL---EFEMRHLQRE 733 L+ EL + N+K +++ LT + +E + + IE + ++ LQ E Sbjct: 1108 LQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEE 1167 Query: 734 YLSLSDKI 741 + L++++ Sbjct: 1168 NVKLAEEL 1175 Score = 68.2 bits (165), Expect = 3e-11 Identities = 147/768 (19%), Positives = 310/768 (40%), Gaps = 111/768 (14%) Query: 6 QHREEDEVDSVLLSASK----ILNSSEGVKESGCS-----DTEYGCIAESENQIQP---- 52 +H ++ D + L SK I + + ++E S TE AE + QI+ Sbjct: 599 EHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLD 658 Query: 53 -QSALKVLQQQLESFQALR---MQTLQNVSMPTENQEENL---------SMEKSHHFEDS 99 Q ++ LQ Q +S +A M+ L+ M ++EN E H E Sbjct: 659 YQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEME 718 Query: 100 KTLHSVEE-KLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHP--SENSDI 156 TL+ ++E ++ + L N +++ T L+ + + L + SE Sbjct: 719 DTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSE 778 Query: 157 LKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGF-CENLDDICHSIKQMKEEL 215 +K ++ + + S IT NL + + Q+KE L Sbjct: 779 MKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETL 838 Query: 216 QKSHDGEVALTNE--LQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSK 273 +K E+ + E + + V R+ + ++ +HQ KEE + L+ D++ Sbjct: 839 EK----ELQILKEKFAEASEEAVSVQRSMQETVNKLHQ------KEEQFN-MLSSDLEKL 887 Query: 274 R--ISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNI 331 R ++++EA ++ E + K ++ K + K N E+ + +++ Sbjct: 888 RENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDV 947 Query: 332 TDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTS----------KVN 381 +L+ SFL ++ +M K Q ++ + E EK K+ Sbjct: 948 EELQLKLTKANENASFLQKSIEDMTVKAEQS--QQEAAKKHEEEKKELERKLSDLEKKME 1005 Query: 382 SVTEQCVA-KIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYE 440 + QC K +Y + + + ++ + L+ L+ + K+K L+Q++E Sbjct: 1006 TSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELR 1065 Query: 441 KQLKNL-----VEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQ- 494 KQ E+ I +++K + + L++ K+ +K LQ + TL+E N++ Sbjct: 1066 KQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAK---LQNELDTLKENNLKN 1122 Query: 495 ----------LSLEKQQMME---ALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNI 541 L++E Q+M E ++ LK + ++ + EN +++ E+ + Sbjct: 1123 VEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRD-- 1180 Query: 542 LLIQDEKEMLEKKTHQLLKEKSSLGN----ELKESQLEIIQLKEKERLAKTEQETLLQII 597 E +HQ L+E+ S+ N E+K+ + + I+ ++E+ + + ++ + Sbjct: 1181 ----------EVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSAL 1230 Query: 598 ETVKDEKL----NLETTLQESTAARQIMEREIENIQTYQSTAE---ENFLQEIKNAKSEA 650 T KD +L N T L+ A+ + + ++ +++ + E +N ++K K + Sbjct: 1231 LTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQL 1290 Query: 651 SIYKNSLSEIGKECE--------MLSKMVMETKTDNQILKEELKKHSQ 690 S + E E L+ ++++ + NQ LK +++ S+ Sbjct: 1291 SSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1338 Score = 62.4 bits (150), Expect = 2e-09 Identities = 115/557 (20%), Positives = 225/557 (40%), Gaps = 91/557 (16%) Query: 266 LNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNE---KNNK 322 L D + + ELEA + +L E + K + L++ E + K + + + Sbjct: 394 LARDGHDQHVLELEAKMDQLRTMVEAADR------EKVELLNQLEEEKRKVEDLQFRVEE 447 Query: 323 EIPITGKNITDLKF-HSRVPRYTLSFL------DQTKHEMKDKERQPFLVKQGSIISENE 375 E G T K H+R+ S L D+ + E++D K + E + Sbjct: 448 ESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKD 507 Query: 376 KTSKVNSVTE--------QCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIF 427 +V V E + + + L+E +Q+K+ +++ + +K Sbjct: 508 LALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLK---- 563 Query: 428 TTQSLIQKVETYEKQLK-------NLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNV 480 + + ET++K++K L +E +++SKL + + + + +K + Sbjct: 564 --EHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLE--TA 619 Query: 481 LQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMA--IVNNENNRMSI------ 532 + + +EE + S +LK++ K + D I N +N + S Sbjct: 620 IASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAK 679 Query: 533 EMEAMKTNILLIQDEKE--------MLEKKTHQLLKEKSSLGNELKESQ-----LEIIQL 579 EMEA++ ++ + EKE L+K Q L E N+L+E++ LE++Q Sbjct: 680 EMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQA 739 Query: 580 KEKER----------LAKTEQETL-LQIIETVKDE-KLNLETTLQESTAA-RQIMEREIE 626 K E+ L TE++ L L + E K ++ Q+ AA +QI EIE Sbjct: 740 KCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIE 799 Query: 627 NIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELK 686 + +S+ + +E++ + + + + +LSE+ + E L K + QILKE+ Sbjct: 800 --KNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKEL-------QILKEKFA 850 Query: 687 KHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHN 746 + S+E + + S+ N + E + + L ++ L+ + K + Sbjct: 851 EASEEAVSVQRSMQETV-------NKLHQKEEQFNMLSSDLEKLRENLADMEAKF--REK 901 Query: 747 DPSKTTYISRREKFHFD 763 D + I +EK D Sbjct: 902 DEREEQLIKAKEKLEND 918 Score = 53.1 bits (126), Expect = 1e-06 Identities = 114/599 (19%), Positives = 239/599 (39%), Gaps = 64/599 (10%) Query: 2 SPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQ 61 S K+ R++ E + +I ++E K S + G + N + S + +++ Sbjct: 777 SEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKE 836 Query: 62 QLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEK---LSGDSVNSLP 118 LE +Q L+ E EE +S+++S E LH EE+ LS D Sbjct: 837 TLEK----ELQILKEKF--AEASEEAVSVQRSMQ-ETVNKLHQKEEQFNMLSSDLEKLRE 889 Query: 119 QSVNVPSQIHSEDT-----LTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPN 173 ++ ++ +D + + +N + I+ +NS L N+ R Sbjct: 890 NLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEE 949 Query: 174 VMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVA-LTNELQTL 232 + + L K+ FL+ ++++D+ +Q ++E K H+ E L +L L Sbjct: 950 LQLK-----LTKANENASFLQ----KSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDL 1000 Query: 233 QTDPDVHRNGKYDMSPIHQDKMNFIKE------ENLDGNL--NEDIKSKRISELEALVKK 284 + + N ++ ++ + K +NL L ED E L+++ Sbjct: 1001 EKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQE 1060 Query: 285 LLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEI--PITGKNITDLKFHSRVPR 342 L R+ K K + ++ M ++ K E + T+ K + + Sbjct: 1061 LEELRKQADK------AKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDT 1114 Query: 343 YTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESV 402 + L + K KE L + + E K ++ ++ + K Q L +E+V Sbjct: 1115 LKENNLKNVEELNKSKE---LLTVENQKMEEFRK--EIETLKQAAAQKSQQLSALQEENV 1169 Query: 403 QIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEE 462 ++ +++ E + + + L++ + K +K+ EEK+++Q +S T Sbjct: 1170 KLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSA 1229 Query: 463 YSKECLKEFKKIISKYNVLQGQN----------KTLEEKNIQLSLE----KQQMMEALDQ 508 E E +K+ ++ VL+G+N +TLE ++L L+ + Q+ E Q Sbjct: 1230 LLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQ 1289 Query: 509 LKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGN 567 L S T + + + +++ + + I+ +Q + + L+ K +++ E + GN Sbjct: 1290 LSSSSGNTDTQ---ADEDERAQESQIDFLNSVIVDLQRKNQDLKMKV-EMMSEAALNGN 1344 >gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] Length = 2230 Score = 82.4 bits (202), Expect = 1e-15 Identities = 142/703 (20%), Positives = 280/703 (39%), Gaps = 98/703 (13%) Query: 43 IAESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTL 102 + ESEN+ L+ LQQ+ E+++ R+ L++ + + +N S + + H E K Sbjct: 548 LTESENK------LRDLQQEAETYRT-RILELESSLEKSLQENKNQSKDLAVHLEAEKNK 600 Query: 103 HSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNN 162 H+ E + V + H + +L+ D L + E +LK Sbjct: 601 HNKE--------------ITVMVEKHKTELESLKHQQDALWT-------EKLQVLKQ--Q 637 Query: 163 FYRFLPTAPPNVMSQADTVILDKSKIT---VPFLKHGFCENLDDICHSIKQMKEELQKSH 219 + + + +T++ DK I + + E LD ++ + EL + Sbjct: 638 YQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVL 697 Query: 220 DGEVALTNELQTLQTDPDVHRN---GKYDMSPIHQDKM--NFIKEENLDGNLNEDIKSKR 274 L EL L+ D + K D H + + IKE + E + Sbjct: 698 KARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQ 757 Query: 275 ISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDL 334 I++LE L+K+ + K L + + H N E I ++ +L Sbjct: 758 INQLELLLKE-----------------RDKHLKEHQAH------VENLEADIK-RSEGEL 793 Query: 335 KFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYL 394 + S S+ T + K E Q ++Q + E E+ V E K Sbjct: 794 QQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVC 853 Query: 395 QNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQ 454 +Q+Q + +LE +N ++ K+K L +S ++ ++Q K ++ EK + Sbjct: 854 TELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMI 913 Query: 455 SKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEH 514 ++ + ++ E L + K+ +K + + N+ E K +++ ME + Q K+KE Sbjct: 914 LQMREGQKKEIEILTQ--KLSAKEDSIHILNEEYETK----FKNQEKKMEKVKQ-KAKEM 966 Query: 515 KTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQL 574 + +++ E ++ E T + L Q EK+ K + + +S G S+L Sbjct: 967 QETLKKKLLDQE---AKLKKELENTALELSQKEKQFNAKMLE--MAQANSAGISDAVSRL 1021 Query: 575 EIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQST 634 E Q ++ E L + + L +I ++ ++KLN + + Q+ E+E Sbjct: 1022 ETNQKEQIESLTEVHRRELNDVI-SIWEKKLNQQAEELQEIHEIQLQEKE---------- 1070 Query: 635 AEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIK 694 QE+ K + ++ E+ KE L + ++ T L+E+LK+ S Sbjct: 1071 ------QEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAH--- 1121 Query: 695 FENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSL 737 ++ L +D+ L+ ++ +E + + E LQ + + L Sbjct: 1122 ----VNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVEL 1160 Score = 75.5 bits (184), Expect = 2e-13 Identities = 135/619 (21%), Positives = 262/619 (42%), Gaps = 91/619 (14%) Query: 199 ENLDDICHSIKQMKEEL--------QKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIH 250 ++L+D K++ EEL +K+ A TNEL + + N Sbjct: 1197 KSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKT---NAILSRISHC 1253 Query: 251 QDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSE 310 Q + +KE L IK+ +SELEA +++L + T++ + F + +L + E Sbjct: 1254 QHRTTKVKEALL-------IKTCTVSELEAQLRQLTEEQNTLN---ISFQQATHQLEEKE 1303 Query: 311 MHRGKKNEKNNKEIPITGKNITDLKF--HSRVPRYTLSFLDQTKHEMKDKERQPFLVKQG 368 K+ K + E +T K + + S + Q K E+ + L+K+ Sbjct: 1304 NQI--KSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKE- 1360 Query: 369 SIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFT 428 EK +++S+++Q LQN S+ + +K + S + L+ Sbjct: 1361 ---ELKEKKVEISSLSKQLTDLNVQLQN----SISLSEKEAAISSLRKQYDEEKCELLDQ 1413 Query: 429 TQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNV-LQGQNKT 487 Q L KV+T K+ + +E+ +K S+ ++ ++ + + + + + L+ ++K Sbjct: 1414 VQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKE 1473 Query: 488 LEEKNIQLSLEKQQMMEA----------LDQLKSKEHKTQSDMAI-----------VNNE 526 EK+ Q++L K+++ + ++ KSK K +S++ + + Sbjct: 1474 AYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDH 1533 Query: 527 NNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLG----NELKESQLEIIQLKEK 582 + +IE+E++ + +K++ K+ Q L+ LG N +KE++ +I+ L+ + Sbjct: 1534 ITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQ 1593 Query: 583 ERLAKTEQETLLQIIETV------KDEKLN-LETTLQESTAA-----RQIMEREIENI-Q 629 K E ET + +E V K+E+L LE L+ +AA ++ E++I I + Sbjct: 1594 VYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKK 1653 Query: 630 TYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLS---KMVMETKTDNQILKEELK 686 S EE Q K +S S L E +E +L K V ++++ I+ K Sbjct: 1654 QLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAK 1713 Query: 687 K----HSQENIKFENSISRLTEDKILL--------ENYVRSIENERD---TLEFEMR-HL 730 QE + + + E+KI + E ++ + E++ + FEMR Sbjct: 1714 NVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQY 1773 Query: 731 QREYLSLSDKICNQHNDPS 749 Q + L QH D S Sbjct: 1774 QERLIKLEHAEAKQHEDQS 1792 Score = 63.5 bits (153), Expect = 7e-10 Identities = 140/664 (21%), Positives = 262/664 (39%), Gaps = 172/664 (25%) Query: 208 IKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDK-MNFIKEENLDGNL 266 I QM+E +K E+ + + + + D N +Y+ +Q+K M +K++ + + Sbjct: 913 ILQMREGQKK----EIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKE--M 966 Query: 267 NEDIKSKRISELEALVKKL----LPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNK 322 E +K K + + L K+L L + +F+ + S + E N K Sbjct: 967 QETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQK 1026 Query: 323 EIPITGKNITDLKFHSRVPRYTLSFLD----------QTKHE--MKDKERQPFLVKQGSI 370 E +++T++ H R +S + Q HE +++KE++ +KQ + Sbjct: 1027 E---QIESLTEV--HRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKIL 1081 Query: 371 ISENEKTSKVNSVT---EQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPL-I 426 + EK +T E+ V + L ++ Q V L + LK+ ++ L + Sbjct: 1082 LFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEV 1141 Query: 427 FTTQSLIQKVETYEK--QLKNLVEEK----STIQSKLSKTEEYSKECLKEFKKIISKYNV 480 +SL + E+ +LK L EE S + SKL T+E EF+ + S + Sbjct: 1142 DLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDE-------EFQSLKSSH-- 1192 Query: 481 LQGQNKTLEEKNIQLSLEKQQM----------MEALDQLKSKE----------------- 513 + NK+LE+K+++ +++ EAL + K+ E Sbjct: 1193 -EKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRIS 1251 Query: 514 ---HKT-----------------QSDMAIVNNENNRMSI--------------EMEAMKT 539 H+T ++ + + E N ++I ++++MK Sbjct: 1252 HCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKA 1311 Query: 540 NILLIQDEKEMLEKK---THQLLKEKSS------------------LGNELKESQLEI-- 576 +I + EKE L+K+ Q EK S + ELKE ++EI Sbjct: 1312 DIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISS 1371 Query: 577 ---------------IQLKEKE----RLAKTEQETLLQIIETVKDEKLNLETTLQESTAA 617 I L EKE L K E ++++ V+D ++T +E +A Sbjct: 1372 LSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISA 1431 Query: 618 RQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTD 677 +E + + + F + K A+S + ++N++ E+ + E+ SK E Sbjct: 1432 -------LEQVDDWSN----KFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQ 1480 Query: 678 NQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSL 737 +LKEEL Q+N +F+ + +DK +E + LE E++ + L Sbjct: 1481 INLLKEEL---DQQNKRFDCLKGEMEDDK-------SKMEKKESNLETELKSQTARIMEL 1530 Query: 738 SDKI 741 D I Sbjct: 1531 EDHI 1534 Score = 56.2 bits (134), Expect = 1e-07 Identities = 97/464 (20%), Positives = 204/464 (43%), Gaps = 81/464 (17%) Query: 349 DQTKHEMKDKERQPFLVKQGSIISENE-----KTSKVNSVTE--------------QCVA 389 D++K E K+ + L Q + I E E KT ++ S+ E + V Sbjct: 1505 DKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQ 1564 Query: 390 KIQYLQNYLKES----VQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKN 445 K+Q+ Q +E + ++K++ LE++ ++K++++ + + V++ E++LK Sbjct: 1565 KLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKA 1624 Query: 446 LVEE-KSTIQSKLSKTEEYSKECLKEFKK-IISKYNVLQGQNKT-----LEEKNIQLSLE 498 L + +S +KL++ + +++ + KK ++S+ + Q K L E N +L Sbjct: 1625 LEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQER 1684 Query: 499 KQQMMEALDQLKSKEHKTQSDMAIV------------NNENNRMSIEMEAMKTNILLIQ- 545 ++++ ++LKS E +QS+ IV E + + + I ++Q Sbjct: 1685 EREVHILEEKLKSVE-SSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQR 1743 Query: 546 --DEKEMLEKKTHQLLKEKSSLGNELK-ESQLEIIQLKEKERLAKTEQETLLQIIETVKD 602 EKE L ++ Q +E S E++ + Q +I+L+ E +Q + + E +++ Sbjct: 1744 NLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEE 1803 Query: 603 EKLNLETTLQE---------STAARQIMEREIENIQTYQSTAEENFL------QEIKNAK 647 + + + + A+Q +E +++Q T +E L Q+IK Sbjct: 1804 KNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQ---KTLQEKELTCQILEQKIKELD 1860 Query: 648 S----EASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLT 703 S + +++ + E+ + E L + + D + EL + + E E S S L Sbjct: 1861 SCLVRQKEVHRVEMEELTSKYEKLQAL---QQMDGRNKPTELLEENTE----EKSKSHLV 1913 Query: 704 EDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHND 747 + K+L ++E + + LEF++ +RE L +I D Sbjct: 1914 QPKLL-----SNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKD 1952 Score = 47.4 bits (111), Expect = 5e-05 Identities = 151/760 (19%), Positives = 303/760 (39%), Gaps = 142/760 (18%) Query: 5 KQHREEDEVDSVLLS-ASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQQL 63 K ++E +++ L S ++I+ + + + + ++ NQ Q K L Q+L Sbjct: 1508 KMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQ-QKDIEHKELVQKL 1566 Query: 64 ESFQAL-------------RMQTLQN--VSMPTENQEENLSMEKSHHFEDSKT--LHSVE 106 + FQ L ++ TL+N SM E + + +E + SK L ++E Sbjct: 1567 QHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALE 1626 Query: 107 EKLSGDSVNSLPQSVNVPSQ----IHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNN 162 ++L +S L + Q I + + + H SE + L+ Sbjct: 1627 DRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQERER 1686 Query: 163 FYRFLPTAPPNV-MSQADTVILDKS-KITVPFLKHGFCENLDDICHSIKQMKEELQKSHD 220 L +V SQ++T+I+ +S K + + ++ + + ++ LQ++ Sbjct: 1687 EVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLT 1746 Query: 221 GEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEA 280 + L LQ + + + + ++M +Q+++ IK E+ + +ED I L+ Sbjct: 1747 EKEKL---LQRVGQEKEETVSSHFEMRCQYQERL--IKLEHAEAKQHED--QSMIGHLQE 1799 Query: 281 LVKKLLPFRETVSKFHVHFCRKCKKLSKS-EMHRGKKNEKNNKEIPITGKNI-TDLKFHS 338 +++ K KK S H K+ KNN + +N+ D++ Sbjct: 1800 ELEE-----------------KNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTL 1842 Query: 339 RVPRYTLSFLDQTKHEMKDKERQPFLVKQGSI--ISENEKTSKVNSVTEQCVAKIQYLQN 396 + T L+Q K KE LV+Q + + E TSK K+Q LQ Sbjct: 1843 QEKELTCQILEQ-----KIKELDSCLVRQKEVHRVEMEELTSKYE--------KLQALQQ 1889 Query: 397 Y---------LKESVQ-------IQKKVME-LESENLNLKSKMKPLIFTTQSLIQKVETY 439 L+E+ + +Q K++ +E+++ +L+ K+ Q L +++ Sbjct: 1890 MDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRL 1949 Query: 440 EKQLKNLVEEKSTIQSKLSKT-EEYSKECLKE------------FKKIISKYNVLQGQNK 486 +K L+ L +E L K ++ +E +K+ K+++ ++N Q + Sbjct: 1950 QKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKE 2009 Query: 487 TLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMS-----------IEME 535 E I+ ++ K Q +EA + L+S + +T + + +++ + E Sbjct: 2010 QELEMTIKETINKAQEVEA-ELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREE 2068 Query: 536 AMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQ 595 M + +Q + E L+KK Q L+++ + GN+ + I++L Q L Q Sbjct: 2069 EMTAKVRDLQTQLEELQKKYQQKLEQEENPGND----NVTIMEL----------QTQLAQ 2114 Query: 596 IIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEEN-FLQEIKNAKSEASIYK 654 + D KL Q +I N++ E+N + + ++Y Sbjct: 2115 KTTLISDSKLK-----------EQEFREQIHNLEDRLKKYEKNVYATTVGTPYKGGNLYH 2163 Query: 655 NSLSEIGK--ECEMLSKMVM------ETKTDNQILKEELK 686 +S G+ E E L K++ ETKT +++ LK Sbjct: 2164 TDVSLFGEPTEFEYLRKVLFEYMMGRETKTMAKVITTVLK 2203 Score = 45.1 bits (105), Expect = 3e-04 Identities = 73/381 (19%), Positives = 169/381 (44%), Gaps = 86/381 (22%) Query: 430 QSLIQKVETYEKQLKN--------------LVEEKSTIQSKLSKTEEYSKECLKEFKKII 475 + LIQ++ E+ L + L EK +Q LS++++ S + E ++ + Sbjct: 137 EQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREEL 196 Query: 476 -----SKYNVLQGQNKTLEEKN-------IQLSLEKQQM---------MEALDQLK---- 510 +K ++ + + +LEEK+ Q+SL KQ++ ++ L QL+ Sbjct: 197 QMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAE 256 Query: 511 --SKEHKTQSD------------------MAIVNNEN--NRMSIEMEAMKTNILLIQDEK 548 +KE +SD + EN R +++ K L+ EK Sbjct: 257 VFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEK 316 Query: 549 EMLEKKTHQLLKE-----------KSSLGNELKESQLEIIQLKEKERLAKTE-QETLLQI 596 E L+++ + L+E K+ L +L++++ I QL++ + + E + + + Sbjct: 317 EALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHET 376 Query: 597 IETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNS 656 +E ++E L + +++ T + E ++ + +E +E++ A S A + + Sbjct: 377 LEMKEEEIAQLRSRIKQMTT-------QGEELREQKEKSERAAFEELEKALSTAQKTEEA 429 Query: 657 LSEIGKECEMLSKMVMETKTDNQI-LKEELKKHSQENIKFENSISRLTEDKI--LLENYV 713 ++ E + K + +T + +I L++EL + QE + + + + +E++I L + + Sbjct: 430 RRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVV---DVMKKSSEEQIAKLQKLHE 486 Query: 714 RSIENERDTLEFEMRHLQREY 734 + + + L +++ +RE+ Sbjct: 487 KELARKEQELTKKLQTREREF 507 >gi|58530840 desmoplakin isoform I [Homo sapiens] Length = 2871 Score = 82.0 bits (201), Expect = 2e-15 Identities = 158/800 (19%), Positives = 309/800 (38%), Gaps = 109/800 (13%) Query: 45 ESEN----QIQPQSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSK 100 E EN +++ + A+K + ++E + L LQ E L+ ++H+ E+ Sbjct: 1149 EKENLGWQKLESEKAIKEKEYEIERLRVL----LQEEGTRKREYENELAKVRNHYNEEMS 1204 Query: 101 TLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSE----NSDI 156 L + E +N ++ S +D+ LR D LS E N I Sbjct: 1205 NLRNKYET----EINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSI 1260 Query: 157 LKNYNNFYRFLPTAPPNVMSQ--ADTVILDKSKITVPFLKHGFCENLDDICH-------- 206 L+ R A N + Q + I+ K + LK + +D Sbjct: 1261 LQATEQRRR----AEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEA 1316 Query: 207 ---------SIKQMKEELQKSHDGEVALTNELQTLQTDPD---VHRNGKYDM------SP 248 I+++K E Q+ NEL ++ + D + +++ + Sbjct: 1317 AKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTT 1376 Query: 249 IHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSK 308 IHQ M KEE+ G + R E +L +++ + T+++ + R+ ++ + Sbjct: 1377 IHQLTMQ--KEEDTSGYRAQIDNLTR--ENRSLSEEIKRLKNTLTQTTENL-RRVEEDIQ 1431 Query: 309 SEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQG 368 + G + + +++ + + +T ++ V RY S LD ++DK ++ +KQ Sbjct: 1432 QQKATGSEVSQRKQQLEVELRQVTQMRTEESV-RYKQS-LDDAAKTIQDKNKEIERLKQ- 1488 Query: 369 SIISENEKTSKVNSVTEQCVAKIQY-LQNYLKESVQIQKKVMELESENLNLKSKMKPLIF 427 +I + K + ++QY LQ + + K+ E E L+ + + Sbjct: 1489 -LIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQ 1547 Query: 428 TTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKT 487 Q + ++ LK L +K ++ +L++ + + E + KK+ + L+G ++ Sbjct: 1548 ERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEE---LEGMRRS 1604 Query: 488 LEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNN----------ENNRMSIEMEAM 537 L+E+ I+++ QQ+ +A K E + +++ E R+S E+EA+ Sbjct: 1605 LKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEAL 1664 Query: 538 KTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQII 597 + +L Q+ + + K L ES++EI E L + Sbjct: 1665 RRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEI--------------ERLQSLT 1710 Query: 598 ETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSL 657 E + E L LE L+ + E ++++ +S A+ + I +S+ I N Sbjct: 1711 ENLTKEHLMLEEELRN-------LRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRT 1763 Query: 658 SEIG--------------KECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLT 703 E+ +E E K +E Q K + + QE I L Sbjct: 1764 LELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLE 1823 Query: 704 EDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRREKFHFD 763 +DK L+ + + TLE E R QR L + + KT Y SR+E+ Sbjct: 1824 QDKARLQRLEDELNRAKSTLEAETRVKQR--LECEKQQIQNDLNQWKTQY-SRKEEAIRK 1880 Query: 764 NYTHEDTSSPQSRPLASDLK 783 + + S + L S+++ Sbjct: 1881 IESEREKSEREKNSLRSEIE 1900 Score = 61.2 bits (147), Expect = 4e-09 Identities = 91/408 (22%), Positives = 169/408 (41%), Gaps = 84/408 (20%) Query: 392 QYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKS 451 Q LQ Y E Q + K+ LE LK + + +S Q ++ Q+K L E+ + Sbjct: 1060 QNLQKYQAECSQFKAKLASLEE----LKRQAE---LDGKSAKQNLDKCYGQIKELNEKIT 1112 Query: 452 TIQSKLSKTEEYSKECLKEFKKIISKYNVLQ----------GQNKTLEEKNI-QLSLEKQ 500 + ++ + K F + + Y+ LQ G K EK I + E + Sbjct: 1113 RLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIE 1172 Query: 501 QMMEALDQLKSKEHKTQSDMAIVNNE--------NNRMSIEMEAMKTNILLIQDEKEMLE 552 ++ L + +++ + ++++A V N N+ E+ KT I I +KE Sbjct: 1173 RLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDS 1232 Query: 553 KKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQ 612 K L S +LK+ EI++L + I++ + + E LQ Sbjct: 1233 KNLRNQLDRLSRENRDLKD---EIVRLND-------------SILQATEQRRRAEENALQ 1276 Query: 613 ESTAARQIMER----EIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLS 668 + +IM++ EIE Q Q +E+N + +K SL E + Sbjct: 1277 QKACGSEIMQKKQHLEIELKQVMQQRSEDN------------ARHKQSLEE-------AA 1317 Query: 669 KMVMETKTDNQILKEELKKHSQENIKFENSISRL----TEDKILLEN------------- 711 K + + + + LK E ++ ++ ++EN +S++ E+ I L+N Sbjct: 1318 KTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTI 1377 Query: 712 YVRSIENERDTLEF--EMRHLQREYLSLSDKICNQHNDPSKTTYISRR 757 + +++ E DT + ++ +L RE SLS++I N ++TT RR Sbjct: 1378 HQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRR 1425 Score = 56.2 bits (134), Expect = 1e-07 Identities = 84/408 (20%), Positives = 182/408 (44%), Gaps = 78/408 (19%) Query: 202 DDICHSIKQMKEELQKSH----DGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFI 257 +D C K+++EEL+ + + +TN Q L+ V + + D+ Sbjct: 1586 EDSCKR-KKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQ--------- 1635 Query: 258 KEENLDGNLNEDIKSKR-----ISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMH 312 + + LDG+L E +++ SE+EAL ++LL +E+V + H+ Sbjct: 1636 QRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHL--------------- 1680 Query: 313 RGKKNEKNNKEIPITGKNITDLKFH-SRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSII 371 +NE K I +++ + K R+ T + + H M ++E + ++ + Sbjct: 1681 ---RNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKE--HLMLEEELRNLRLEYDDLR 1735 Query: 372 -SENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQ 430 +E S N+ + +++Q N ++++Q + +L+ E NL+ Sbjct: 1736 RGRSEADSDKNATILELRSQLQISNN---RTLELQGLINDLQRERENLR----------- 1781 Query: 431 SLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEE 490 Q++E ++KQ +E + IQ +++ + ++E + ++ K VL+ L+ Sbjct: 1782 ---QEIEKFQKQA---LEASNRIQ----ESKNQCTQVVQERESLLVKIKVLEQDKARLQR 1831 Query: 491 KNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEM 550 +L+ K + EA ++K + + + + N+ N+ + + I I+ E+E Sbjct: 1832 LEDELNRAKSTL-EAETRVKQR---LECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREK 1887 Query: 551 LEKKTHQLLKEKSSLGNELKESQLEIIQLKE--KERLAKTEQETLLQI 596 E +EK+SL +E++ Q EI +++E + +L + +ET Q+ Sbjct: 1888 SE-------REKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQL 1928 Score = 39.7 bits (91), Expect = 0.011 Identities = 111/615 (18%), Positives = 238/615 (38%), Gaps = 153/615 (24%) Query: 58 VLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSL 117 V Q + FQ +L+ + + + EE L+ K EDS +EE+L G + Sbjct: 1551 VKDQDITRFQ----NSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLK 1606 Query: 118 PQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQ 177 Q++ + NL+ + E + I+K + ++ Q Sbjct: 1607 EQAIKI----------------TNLTQQL-----EQASIVKK---------RSEDDLRQQ 1636 Query: 178 ADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPD 237 D LD ++ +EEL++ AL +L LQ Sbjct: 1637 RDV--------------------LDGHLREKQRTQEELRRLSSEVEALRRQL--LQEQES 1674 Query: 238 VHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHV 297 V K ++ E+ + + KS+ ++E + +++L E ++K H+ Sbjct: 1675 V--------------KQAHLRNEHFQKAIED--KSRSLNESKIEIERLQSLTENLTKEHL 1718 Query: 298 HFCRKCK--KLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVP---RYTLSFLDQTK 352 + + +L ++ RG+ ++ KN T L+ S++ TL Sbjct: 1719 MLEEELRNLRLEYDDLRRGRSEADSD-------KNATILELRSQLQISNNRTLELQGLIN 1771 Query: 353 HEMKDKE--RQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVME 410 +++E RQ Q + E ++++ QC +Q +ES+ ++ KV+E Sbjct: 1772 DLQRERENLRQEIEKFQKQAL---EASNRIQESKNQCTQVVQE-----RESLLVKIKVLE 1823 Query: 411 LESENL----NLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSK----LSKTEE 462 + L + ++ K + + Q++E ++Q++N + + T S+ + K E Sbjct: 1824 QDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIES 1883 Query: 463 YSKECLKEFKKIISKYNVLQGQNKTLEEK------------NIQLSLEKQQMMEALDQLK 510 ++ +E + S+ LQ + K +EE+ QL E+ + +D+L+ Sbjct: 1884 EREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLR 1943 Query: 511 S------KEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQ-DEKEMLEKKT-HQLLKEK 562 +E +T+ + + + + + ++ + +Q E ++++K T +LLK K Sbjct: 1944 QRPYGSHRETQTECEWTV-----DTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGK 1998 Query: 563 SSLGNELKESQ-------------------LEIIQLKEKERLAKTEQETLLQ-------I 596 S+ E Q +++ K K+ ++ LL+ I Sbjct: 1999 KSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGI 2058 Query: 597 IETVKDEKLNLETTL 611 I+ ++EKL +++ + Sbjct: 2059 IDPHRNEKLTVDSAI 2073 >gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] Length = 1684 Score = 81.3 bits (199), Expect = 3e-15 Identities = 133/586 (22%), Positives = 236/586 (40%), Gaps = 62/586 (10%) Query: 182 ILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHR- 240 +++K K + L FC ++ ++ +KE+ QK E++ NE T +D + + Sbjct: 400 VIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQK----EISELNE--TFLSDSEKEKL 453 Query: 241 NGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFC 300 +++ + + N +++E + LN + + E+ +++ L E+ K F Sbjct: 454 TLMFEIQGLKEQCEN-LQQEKQEAILNYE----SLREIMEILQTELG--ESAGKISQEF- 505 Query: 301 RKCKKLSKSEMHR---------GKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQT 351 K+ S++H +K+ + G+N L VP L+ T Sbjct: 506 ESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPE-----LENT 560 Query: 352 KHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMEL 411 +++K L E K+NS+TE+ I L+N +E KK Sbjct: 561 IKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCERE 620 Query: 412 ESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEF 471 E L L K++ I L QKV L+ ++EK KL K + + Sbjct: 621 ERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEK-------LMVQM 673 Query: 472 KKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMS 531 K + VL + K+L E+N +LS EK+Q+ L+ S++ I E Sbjct: 674 KVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQL 733 Query: 532 IEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQE 591 + E N LL ++ + L KT QL +G+E+ E E K+ + + E Sbjct: 734 MVEEQDNLNKLLENEQVQKLFVKT-QLYGFLKEMGSEVSEDSEE----KDVVNVLQAVGE 788 Query: 592 TLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEAS 651 +L +I +EK NL E +E+EI+ +Q E +++ + E Sbjct: 789 SLAKI----NEEKCNLAFQRDEKVLE---LEKEIKCLQEESVVQCEELKSLLRDYEQEKV 841 Query: 652 IYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLEN 711 + + L EI E E L ++E K N+ + E +N+ + T K + N Sbjct: 842 LLRKELEEIQSEKEALQSDLLEMKNANEKTRLE-----NQNLLIQVEEVSQTCSKSEIHN 896 Query: 712 -----YVRSIENERDTLE-FEMRHLQREYLSLSDKICNQ---HNDP 748 +++ EN + LE E+R + E + L D + NDP Sbjct: 897 EKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDP 942 Score = 80.5 bits (197), Expect = 6e-15 Identities = 139/672 (20%), Positives = 278/672 (41%), Gaps = 97/672 (14%) Query: 85 EENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHS---EDTLTLRTST-D 140 +E LS E +E++ L S +++LS D L Q +V + H E L L D Sbjct: 680 KEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQD 739 Query: 141 NLSSNIIIHPSENSDILKNY--NNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFC 198 NL+ + EN + K + Y FL V ++ +K + V Sbjct: 740 NLNKLL-----ENEQVQKLFVKTQLYGFLKEMGSEVSEDSE----EKDVVNV-------- 782 Query: 199 ENLDDICHSIKQMKEE---LQKSHDGEVA-LTNELQTLQTDPDVH-RNGKYDMSPIHQDK 253 L + S+ ++ EE L D +V L E++ LQ + V K + Q+K Sbjct: 783 --LQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEK 840 Query: 254 MNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFH-------VHFCRKCKKL 306 + KE E+I+S++ EAL LL + K + + Sbjct: 841 VLLRKEL-------EEIQSEK----EALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTC 889 Query: 307 SKSEMHRGKKN----EKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQP 362 SKSE+H K+ E N + + K + D + + + +L+ K++ ++ Sbjct: 890 SKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKEL 949 Query: 363 FLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKM 422 + EK K+N + V + L + KE+ +++++ L SE L + M Sbjct: 950 EEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASM 1009 Query: 423 KPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECL----------KEFK 472 + LI +S + YEKQ + L EK + + E+ +++ + + Sbjct: 1010 RDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNE 1069 Query: 473 KIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSI 532 ++++ LQ K LE + +++ K + + L+ K ++ + + A NE + + Sbjct: 1070 DLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQV 1129 Query: 533 EMEAMKTNILLIQDEKEMLEKKTHQ-------------LLKEKSSLGNELKESQLEIIQL 579 +++ K + E E+++K Q L+KE L +L +I L Sbjct: 1130 QLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKE---LNQKLTNKNNKIEDL 1186 Query: 580 KEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIM-EREIENIQTYQSTAEEN 638 +++ ++ K +QETL + I +++ E +++T +Q++ + + E + Q+ + Sbjct: 1187 EQEIKIQKQKQETLQEEITSLQSSVQQYE---EKNTKIKQLLVKTKKELADSKQAETDHL 1243 Query: 639 FLQ-----EIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENI 693 LQ E++ ++ + +YK L+EI E + ++ LK ++H + Sbjct: 1244 ILQASLKGELEASQQQVEVYKIQLAEITSEKHKI----------HEHLKTSAEQHQRTLS 1293 Query: 694 KFENSISRLTED 705 ++ ++ L E+ Sbjct: 1294 AYQQRVTALQEE 1305 Score = 77.4 bits (189), Expect = 5e-14 Identities = 118/556 (21%), Positives = 242/556 (43%), Gaps = 64/556 (11%) Query: 193 LKHGFCENLDDICHSIKQMK---EELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPI 249 L+ F E D + ++ +++ E+L + L N ++ LQ +NG Y +S Sbjct: 523 LRTAFTEK-DALLETVNRLQGENEKLLSQQELVPELENTIKNLQ-----EKNGVYLLSLS 576 Query: 250 HQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKS 309 +D M +KE L+G +N + K + + KL E + FH +KC++ + Sbjct: 577 QRDTM--LKE--LEGKINSLTEEK-----DDFINKLKNSHEEMDNFH----KKCEREERL 623 Query: 310 EMHRGKKNEKN---NKEIP-----ITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQ 361 + GKK E+ N E+ +TG LK + + + Q K +DKE Sbjct: 624 ILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKE-- 681 Query: 362 PFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNY-----LKESV-QIQKKV--MELES 413 V + S E+ +K++S +Q ++ + LKE + Q++KK+ M E Sbjct: 682 ---VLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQ 738 Query: 414 ENLN--LKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEF 471 +NLN L+++ +F L ++ ++ EEK + + E +K + E Sbjct: 739 DNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAK--INEE 796 Query: 472 KKIISKYNVLQGQNKTLE-EKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRM 530 K ++ Q K LE EK I+ L+++ +++ ++LKS + + ++ E + Sbjct: 797 KCNLA----FQRDEKVLELEKEIKC-LQEESVVQC-EELKSLLRDYEQEKVLLRKELEEI 850 Query: 531 SIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQ 590 E EA+++++L +++ E + LL + + +S++ EKE+ E Sbjct: 851 QSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIH----NEKEKCFIKEH 906 Query: 591 ETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEA 650 E L ++E + E L + + A+ +++ ++ + ++I+N + E Sbjct: 907 ENLKPLLEQKELRDRRAELILLKDSLAKS------PSVKNDPLSSVKELEEKIENLEKEC 960 Query: 651 SIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLE 710 + +++I K + ++ + Q +KEEL+ E + S+ L + + Sbjct: 961 KEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYK 1020 Query: 711 NYVRSIENERDTLEFE 726 N + E + + L+ E Sbjct: 1021 NLLLEYEKQSEQLDVE 1036 Score = 64.7 bits (156), Expect = 3e-10 Identities = 131/755 (17%), Positives = 307/755 (40%), Gaps = 88/755 (11%) Query: 23 ILNSSEGVKESGCSDTEYGC---IAESENQIQPQSALKVLQQQLESFQALRMQTLQNVSM 79 ++N + V ES E C E ++ + +K LQ++ ++ + L+ S+ Sbjct: 779 VVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEE----SVVQCEELK--SL 832 Query: 80 PTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTST 139 + ++E + + K + + + S +E L D + ++ N +++ +++ L Sbjct: 833 LRDYEQEKVLLRK-----ELEEIQSEKEALQSDLLEM--KNANEKTRLENQNLLIQVEEV 885 Query: 140 DNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCE 199 S IH + +K + N L +A+ ++L S P +K+ Sbjct: 886 SQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDR-RAELILLKDSLAKSPSVKNDPLS 944 Query: 200 NLDDICHSI----KQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMN 255 ++ ++ I K+ KE+ +K + ++ + L + + K ++ + +K Sbjct: 945 SVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEK-- 1002 Query: 256 FIKEENLDGNLNEDIKSKR-----ISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSE 310 + L ++ + I+ + E E ++L +E + F ++L S Sbjct: 1003 ----DQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNST 1058 Query: 311 MHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSI 370 + N N + I L+ ++++ + + + K M DKE + +++ Sbjct: 1059 LQCETINSDNEDLLA----RIETLQSNAKLLEVQILEVQRAK-AMVDKELEAEKLQKEQK 1113 Query: 371 ISENEKT-SKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNL---KSKMKPLI 426 I E+ T +++ + Q + + LQ ++E ++K + N+ + + MK L Sbjct: 1114 IKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELN 1173 Query: 427 FTTQSLIQKVETYEKQLK-------NLVEEKSTIQSKLSKTEEYS----------KECLK 469 + K+E E+++K L EE +++QS + + EE + K+ L Sbjct: 1174 QKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELA 1233 Query: 470 EFKKIISKYNVLQGQNK-TLEEKNIQLSLEKQQMMEALDQ-------LKSKEHKTQSDMA 521 + K+ + + +LQ K LE Q+ + K Q+ E + LK+ + Q ++ Sbjct: 1234 DSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLS 1293 Query: 522 IVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSL--------GNELKESQ 573 + E A K + E E + + H +LK++ + G + + Sbjct: 1294 AYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREH 1353 Query: 574 LEII--QLKEKERLAKTEQETLLQIIETVKDEKLNL----ETTLQESTAARQIMEREIEN 627 LE++ QLK K + ++ + + ++T++ E L LQE+ + + ++ + Sbjct: 1354 LEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCS 1413 Query: 628 IQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKK 687 IQ+ + Q + S+ + +NS + + + + +ET L+++L K Sbjct: 1414 IQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVET------LQQQLSK 1467 Query: 688 HSQENIKFENSISRLTEDKILLENYVRSIENERDT 722 + + +N + T + + ++++ R+T Sbjct: 1468 MEAQLFQLKNEPT--TRSPVSSQQSLKNLRERRNT 1500 Score = 59.3 bits (142), Expect = 1e-08 Identities = 85/419 (20%), Positives = 187/419 (44%), Gaps = 50/419 (11%) Query: 348 LDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKK 407 LD E + E+Q +K+ +I + E V + + Q NY+KE ++ + Sbjct: 78 LDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNE 137 Query: 408 VMELES----ENLNLKSKMKPLIFTTQSLIQKVE---TYEKQLKNLVEEKSTI------- 453 +M + S + NL+ +++ + T L ++++ E +K L EE I Sbjct: 138 LMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQ 197 Query: 454 ----QSKLSKTEEYSKECLKEFKKIISKYNVLQGQN-KTLEEKNIQL-SLEKQQMMEALD 507 Q +L T + KE + + + II + +N +L+E+ +QL ++ ++++ E + Sbjct: 198 ILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMC 257 Query: 508 QLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGN 567 Q+++ + ++++ +N + + EA EK + +K +L + + N Sbjct: 258 QIEASAKEHEAEINKLNELKENLVKQCEA---------SEKNIQKKYECELENLRKATSN 308 Query: 568 ELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKL-NLETTLQESTAARQIMEREI- 625 +++Q+ I L+E +E V +EK+ +LE TL+E + I++ E+ Sbjct: 309 ANQDNQICSILLQEN------------TFVEQVVNEKVKHLEDTLKELESQHSILKDEVT 356 Query: 626 --ENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECE--MLSKMVMETKTDNQIL 681 N++ ++ E + + + N L + KE + ++ K+ E N+ Sbjct: 357 YMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELL-LAKEEQGCVIEKLKSELAGLNKQF 415 Query: 682 KEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDK 740 +++H++E + + E L E ++ E E+ TL FE++ L+ + +L + Sbjct: 416 CYTVEQHNREVQSLKEQHQK--EISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQE 472 Score = 46.2 bits (108), Expect = 1e-04 Identities = 80/380 (21%), Positives = 164/380 (43%), Gaps = 67/380 (17%) Query: 435 KVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQ 494 K+ET K+ +L++ + K + E KE +++ SK V +G ++ Sbjct: 21 KLETLPKE--DLIKFAKKQMMLIQKAKSRCTELEKEIEELRSK-PVTEGTGDIIKA---- 73 Query: 495 LSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEM---- 550 + E LD L ++ +T+ + EN +M E+E T + E E Sbjct: 74 -------LTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHIN 126 Query: 551 ----LEKKTHQLL-------KEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIET 599 +E ++L+ ++K++L +L+E+ ++L E+ + ++ + ++ E Sbjct: 127 YVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEE 186 Query: 600 V-------KDEKLNLETTLQESTAARQIMEREIENI-----QTYQ---STAEENFLQ--- 641 + +++ L L+ L +T ++ +++NI Q YQ ++ +E LQ Sbjct: 187 IEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKA 246 Query: 642 ----EIKN--AKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKF 695 E+K + EAS K +EI K E+ +V + + + ++ KK+ E Sbjct: 247 IHQEEVKELMCQIEASA-KEHEAEINKLNELKENLVKQCEASEKNIQ---KKYECELENL 302 Query: 696 ENSISRLTEDK-----ILLEN-YVRSIENER-DTLEFEMRHLQREYLSLSDKICNQHNDP 748 + S +D +L EN +V + NE+ LE ++ L+ ++ L D++ +N Sbjct: 303 RKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLK 362 Query: 749 SKTTYISRREKFHFDNYTHE 768 K ++ K D + HE Sbjct: 363 LKLEMDAQHIK---DEFFHE 379 Score = 43.1 bits (100), Expect = 0.001 Identities = 57/266 (21%), Positives = 117/266 (43%), Gaps = 35/266 (13%) Query: 350 QTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQY----------LQNYLK 399 +T+ +++E L+ Q I ++ + + +V+E + ++ LQ + Sbjct: 1343 ETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVS 1402 Query: 400 ESVQIQKKVMELESENLNLKSKMKPLI--FTTQSLIQKVETYEKQLKNLVEEK----STI 453 + ++++K+ ++SEN+ +KS+ + T+Q+ + + ++ Q+++L EE T+ Sbjct: 1403 KEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLR-NSFRDQVRHLQEEHRKTVETL 1461 Query: 454 QSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSL--------EKQQMMEA 505 Q +LSK E + LK S + Q E +N L L E+ + ME Sbjct: 1462 QQQLSKMEAQLFQ-LKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMET 1520 Query: 506 LD--QLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKS 563 D + S TQS ++N+ ++ + + + KE L +K K Sbjct: 1521 TDTESVSSASTYTQSLEQLLNSPETKL-------EPPLWHAEFTKEELVQKLSSTTKSAD 1573 Query: 564 SLGNELKESQLEIIQLKEKERLAKTE 589 L L+E++ L E+ +L K+E Sbjct: 1574 HLNGLLRETEATNAILMEQIKLLKSE 1599 Score = 31.2 bits (69), Expect = 4.0 Identities = 67/330 (20%), Positives = 142/330 (43%), Gaps = 29/330 (8%) Query: 208 IKQMKEELQKSHDGEVALTNELQTLQTDPD--VHRNGKYDMSPIH-----QDKMNFIKEE 260 I Q+K +LQ S + +ELQTLQ++ D + R+ K + ++K+ I+ E Sbjct: 1358 IDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSE 1417 Query: 261 NLDGNLNEDIKSKRISELEALVKKLL-PFRETVSKFHVHFCRKC----KKLSKSEMHRGK 315 N+ + + ++ +S+L + + L FR+ V + ++LSK E + Sbjct: 1418 NM---MMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQ 1474 Query: 316 -KNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISEN 374 KNE + + +++ +L+ L T+ E + E S+ S + Sbjct: 1475 LKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGME----TTDTESVSSAS 1530 Query: 375 EKTSKVNSVTEQCVAKIQ---YLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQS 431 T + + K++ + + KE + +QK +S + +L ++ T Sbjct: 1531 TYTQSLEQLLNSPETKLEPPLWHAEFTKEEL-VQKLSSTTKSAD-HLNGLLRETEATNAI 1588 Query: 432 LIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEK 491 L+++++ + +++ L E++ + K + EY K L +F I K + + + Sbjct: 1589 LMEQIKLLKSEIRRL--ERNQEREKSAANLEYLKNVLLQF--IFLKPGSERERLLPVINT 1644 Query: 492 NIQLSLEKQQMMEALDQLKSKEHKTQSDMA 521 +QLS E++ + A+ Q + + S A Sbjct: 1645 MLQLSPEEKGKLAAVAQGEEENASRSSGWA 1674 >gi|217272802 hyaluronan-mediated motility receptor isoform a [Homo sapiens] Length = 725 Score = 81.3 bits (199), Expect = 3e-15 Identities = 109/545 (20%), Positives = 238/545 (43%), Gaps = 60/545 (11%) Query: 209 KQMKEELQKSHDGEV-ALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLN 267 K+ K+ L D + A ++++ ++ + +N K D+ + ++ ++E Sbjct: 48 KESKQNLNVDKDTTLPASARKVKSSESKKESQKNDK-DLKILEKEIRVLLQERGAQDRRI 106 Query: 268 EDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKS-EMHRGKKNEKNN-KEIP 325 +D++++ + ++EA + L + ++S + ++ +L+++ E+ + K +E N K + Sbjct: 107 QDLETE-LEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLR 165 Query: 326 ITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVK--------QGSIISENEKT 377 I + L+ + R + Q EMK + Q L + +G ++S ++ Sbjct: 166 ILSLELMKLR-NKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEK 224 Query: 378 SKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVE 437 S TE+ ++Y++ S Q++K +++ NLK K ++ QSL + + Sbjct: 225 IDEKSETEKL---LEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIV 281 Query: 438 TYEKQLKNLVEEKSTIQSK----LSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNI 493 KQ+++L + ++ + +++ E+++ E + + K+ + Q + + L++K + Sbjct: 282 ILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKEL 341 Query: 494 QLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEK 553 Q+ QQ E L K Q +M EK + E+ Sbjct: 342 QIDSLLQQEKELSSSLHQKLCSFQEEMV------------------------KEKNLFEE 377 Query: 554 KTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQE 613 + Q L E L + KE Q E + +K+ E AK+ E L + E +K ++ LE + Sbjct: 378 ELKQTLDELDKL--QQKEEQAERL-VKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAA 434 Query: 614 STAARQIMERE-------IENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEM 666 T A +++ + +E++ + + EI++ K E S + ++ GK E Sbjct: 435 HTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAED 494 Query: 667 LSKMVMETKTDNQ-----ILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERD 721 + ++ T++ NQ +L + K +E E ++S L + L + E+ R Sbjct: 495 VQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRK 554 Query: 722 TLEFE 726 LE E Sbjct: 555 QLEDE 559 Score = 70.5 bits (171), Expect = 6e-12 Identities = 80/385 (20%), Positives = 177/385 (45%), Gaps = 28/385 (7%) Query: 372 SENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQS 431 SE++K S+ N + + K ++ L+E +++ +LE+E +++++ + S Sbjct: 72 SESKKESQKNDKDLKILEK--EIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTS 129 Query: 432 LIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEK 491 L T EKQL L ++SK S E +++ L+ I +++ +NK E Sbjct: 130 LSANNATLEKQLIELTRTNELLKSKFS--ENGNQKNLR-----ILSLELMKLRNK--RET 180 Query: 492 NIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEML 551 ++ + KQ+ ME Q+ + + +S I E +SIE E + DEK Sbjct: 181 KMRGMMAKQEGMEMKLQVTQRSLE-ESQGKIAQLEGKLVSIEKEKI--------DEKSET 231 Query: 552 EKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTL 611 EK + ++E S +++++ +L+I QL+E K + + +L + +++++ + L + Sbjct: 232 EKLL-EYIEEISCASDQVEKYKLDIAQLEEN---LKEKNDEILSLKQSLEENIVILSKQV 287 Query: 612 QESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMV 671 ++ Q++E+E E+ EN E++N K + + + ++ ++ + ++ Sbjct: 288 EDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLL 347 Query: 672 METKTDNQILKEELKKHSQENIK----FENSISRLTEDKILLENYVRSIENERDTLEFEM 727 + K + L ++L +E +K FE + + ++ L+ E LE E Sbjct: 348 QQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEA 407 Query: 728 RHLQREYLSLSDKICNQHNDPSKTT 752 + E L +K+ + + K++ Sbjct: 408 KSRAEELKLLEEKLKGKEAELEKSS 432 Score = 54.3 bits (129), Expect = 4e-07 Identities = 94/464 (20%), Positives = 202/464 (43%), Gaps = 50/464 (10%) Query: 257 IKEENLD-GNLNEDIKSKR---ISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMH 312 +++ LD L E++K K +S ++L + ++ + V +V KC+ L K + Sbjct: 248 VEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNV----KCQLLEKEKED 303 Query: 313 RGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIIS 372 +N ++N+ + +N+ ++ L ++ K + K+ + L ++ + S Sbjct: 304 HVNRNREHNENLNAEMQNLKQ--------KFILEQQEREKLQQKELQIDSLLQQEKELSS 355 Query: 373 ENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSL 432 + K+ S E+ V + + LK+++ K+ + E + L +K L +S Sbjct: 356 SLHQ--KLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERL---VKQLEEEAKSR 410 Query: 433 IQKVETYEKQLKNLVEE--KSTI---QSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKT 487 ++++ E++LK E KS+ Q+ L E+Y ++ + + +++ K Sbjct: 411 AEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDS-MVQSLEDVTAQFE----SYKA 465 Query: 488 LEEKNIQ-LSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQD 546 L I+ L LE + E + Q + + N + ++T L + Sbjct: 466 LTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKET 525 Query: 547 EKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQE-TLLQIIETVKDEKL 605 E +++ T L++ + L N+LK+ + + + E E K E+E T ++ E + +L Sbjct: 526 E---IKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRL 582 Query: 606 NLETTLQESTAARQI----MEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIG 661 L L T Q+ E E + + A+E L +I+++ ++ ++N +I Sbjct: 583 -LYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQ-LNKIRDSYAKLLGHQNLKQKI- 639 Query: 662 KECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTED 705 K V++ K +N LK E+ K + K + S ++L E+ Sbjct: 640 -------KHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEE 676 Score = 48.9 bits (115), Expect = 2e-05 Identities = 114/565 (20%), Positives = 217/565 (38%), Gaps = 89/565 (15%) Query: 41 GCIAESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSK 100 G +A+ E + L+V Q+ LE Q ++ L+ + E ++ + EKS E K Sbjct: 184 GMMAKQEGM---EMKLQVTQRSLEESQG-KIAQLEGKLVSIEKEKID---EKS---ETEK 233 Query: 101 TLHSVEE-KLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKN 159 L +EE + D V + + E + + +L NI+I + D+ Sbjct: 234 LLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDL--- 290 Query: 160 YNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQM----KEEL 215 NV Q +L+K K ENL+ ++KQ ++E Sbjct: 291 -------------NVKCQ----LLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQER 333 Query: 216 QKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRI 275 +K E+ + + LQ K S +HQ +F +E + NL E+ + + Sbjct: 334 EKLQQKELQIDSLLQ----------QEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTL 383 Query: 276 SELEALVKKLLPFRETVSKFHVHFCRKCKKLS-KSEMHRGKKNEKNNKEIPITGKNITDL 334 EL+ L +K V + + ++L E +GK+ E Sbjct: 384 DELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAA--------- 434 Query: 335 KFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYL 394 H++ D ++D Q F + SE E NS ++ AK Sbjct: 435 --HTQATLLLQEKYDSMVQSLEDVTAQ-FESYKALTASEIEDLKLENSSLQEKAAKAG-- 489 Query: 395 QNYLKESVQIQKKVMELESEN---------LNLKSKMK--PLIFTTQSLIQKVETYEKQL 443 K + +Q +++ ES N L KS +K + T S +QK+ + QL Sbjct: 490 ----KNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQL 545 Query: 444 KNLVE----EKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEK 499 K E + + + ++ E + E +E K Y L + K + + +EK Sbjct: 546 KQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEK 605 Query: 500 QQMMEALDQLKSKEHKTQSDMA-IVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQL 558 Q ++ + + +K + A ++ ++N + I+ +++ ++DE L+ + +L Sbjct: 606 QALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIK------HVVKLKDENSQLKSEVSKL 659 Query: 559 ---LKEKSSLGNELKESQLEIIQLK 580 L +K +L+E +++ +K Sbjct: 660 RCQLAKKKQSETKLQEELNKVLGIK 684 >gi|217272804 hyaluronan-mediated motility receptor isoform d [Homo sapiens] Length = 638 Score = 80.9 bits (198), Expect = 4e-15 Identities = 102/491 (20%), Positives = 221/491 (45%), Gaps = 37/491 (7%) Query: 257 IKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKS-EMHRGK 315 ++E +D++++ + ++EA + L + ++S + ++ +L+++ E+ + K Sbjct: 9 LQERGAQDRRIQDLETE-LEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSK 67 Query: 316 KNEKNN-KEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVK-------- 366 +E N K + I + L+ + R + Q EMK + Q L + Sbjct: 68 FSENGNQKNLRILSLELMKLR-NKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQL 126 Query: 367 QGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLI 426 +G ++S ++ S TE+ ++Y++ S Q++K +++ NLK K ++ Sbjct: 127 EGKLVSIEKEKIDEKSETEKL---LEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEIL 183 Query: 427 FTTQSLIQKVETYEKQLKNLVEEKSTIQSK----LSKTEEYSKECLKEFKKIISKYNVLQ 482 QSL + + KQ+++L + ++ + +++ E+++ E + + K+ + Q Sbjct: 184 SLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQ 243 Query: 483 GQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNIL 542 + + L++K +Q+ QQ E L K Q +M E N E++ + Sbjct: 244 QEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMV---KEKNLFEEELKQTLDELD 300 Query: 543 LIQDEKEMLEKKTHQLLKEKSSLGNELK--ESQLEIIQLK-EKERLAKTEQETLLQIIET 599 +Q ++E E+ QL +E S ELK E +L+ + + EK A T+ LLQ E Sbjct: 301 KLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQ--EK 358 Query: 600 VKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSE 659 +LE + + + + EIE+++ S+ +E + KNA+ ++ + Sbjct: 359 YDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAED----VQHQILA 414 Query: 660 IGKECEMLSKMVMETKTDNQILKEELKKHS----QENIKFENSISRLTED--KILLENYV 713 + +M+++ +T + + + E+K+ + Q+ +N + + ED K L + Sbjct: 415 TESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEG 474 Query: 714 RSIENERDTLE 724 R E E T E Sbjct: 475 RKAEKENTTAE 485 Score = 67.8 bits (164), Expect = 4e-11 Identities = 74/359 (20%), Positives = 164/359 (45%), Gaps = 26/359 (7%) Query: 398 LKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKL 457 L+E +++ +LE+E +++++ + SL T EKQL L ++SK Sbjct: 9 LQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKF 68 Query: 458 SKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQ 517 S E +++ L+ I +++ +NK E ++ + KQ+ ME Q+ + + + Sbjct: 69 S--ENGNQKNLR-----ILSLELMKLRNK--RETKMRGMMAKQEGMEMKLQVTQRSLE-E 118 Query: 518 SDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEII 577 S I E +SIE E + DEK EK + ++E S +++++ +L+I Sbjct: 119 SQGKIAQLEGKLVSIEKEKI--------DEKSETEKLL-EYIEEISCASDQVEKYKLDIA 169 Query: 578 QLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEE 637 QL+E K + + +L + +++++ + L +++ Q++E+E E+ E Sbjct: 170 QLEEN---LKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNE 226 Query: 638 NFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIK--- 694 N E++N K + + + ++ ++ + ++ + K + L ++L +E +K Sbjct: 227 NLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKN 286 Query: 695 -FENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTT 752 FE + + ++ L+ E LE E + E L +K+ + + K++ Sbjct: 287 LFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSS 345 Score = 48.9 bits (115), Expect = 2e-05 Identities = 114/565 (20%), Positives = 217/565 (38%), Gaps = 89/565 (15%) Query: 41 GCIAESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSK 100 G +A+ E + L+V Q+ LE Q ++ L+ + E ++ + EKS E K Sbjct: 97 GMMAKQEGM---EMKLQVTQRSLEESQG-KIAQLEGKLVSIEKEKID---EKS---ETEK 146 Query: 101 TLHSVEE-KLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKN 159 L +EE + D V + + E + + +L NI+I + D+ Sbjct: 147 LLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDL--- 203 Query: 160 YNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQM----KEEL 215 NV Q +L+K K ENL+ ++KQ ++E Sbjct: 204 -------------NVKCQ----LLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQER 246 Query: 216 QKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRI 275 +K E+ + + LQ K S +HQ +F +E + NL E+ + + Sbjct: 247 EKLQQKELQIDSLLQ----------QEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTL 296 Query: 276 SELEALVKKLLPFRETVSKFHVHFCRKCKKLS-KSEMHRGKKNEKNNKEIPITGKNITDL 334 EL+ L +K V + + ++L E +GK+ E Sbjct: 297 DELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAA--------- 347 Query: 335 KFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYL 394 H++ D ++D Q F + SE E NS ++ AK Sbjct: 348 --HTQATLLLQEKYDSMVQSLEDVTAQ-FESYKALTASEIEDLKLENSSLQEKAAKAG-- 402 Query: 395 QNYLKESVQIQKKVMELESEN---------LNLKSKMK--PLIFTTQSLIQKVETYEKQL 443 K + +Q +++ ES N L KS +K + T S +QK+ + QL Sbjct: 403 ----KNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQL 458 Query: 444 KNLVE----EKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEK 499 K E + + + ++ E + E +E K Y L + K + + +EK Sbjct: 459 KQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEK 518 Query: 500 QQMMEALDQLKSKEHKTQSDMA-IVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQL 558 Q ++ + + +K + A ++ ++N + I+ +++ ++DE L+ + +L Sbjct: 519 QALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIK------HVVKLKDENSQLKSEVSKL 572 Query: 559 ---LKEKSSLGNELKESQLEIIQLK 580 L +K +L+E +++ +K Sbjct: 573 RCQLAKKKQSETKLQEELNKVLGIK 597 >gi|109255234 centrosomal protein 290kDa [Homo sapiens] Length = 2479 Score = 80.5 bits (197), Expect = 6e-15 Identities = 163/809 (20%), Positives = 333/809 (41%), Gaps = 127/809 (15%) Query: 6 QHREEDEVDSVLLSASKI---LNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQQ 62 Q EDEV V + L+ S+ KES C +E E+ N P + ++ L ++ Sbjct: 1673 QENHEDEVKKVKAEVEDLKYLLDQSQ--KESQCLKSELQAQKEA-NSRAPTTTMRNLVER 1729 Query: 63 LESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVN 122 L+S AL+ E Q++ LS T + E +S S +V Sbjct: 1730 LKSQLALK-----------EKQQKALSRALLE-LRAEMTAAAEERIISATSQKEAHLNVQ 1777 Query: 123 VPSQIHSEDTLTLRTSTDNLSSNII-----IHPSEN-----SDILKNYNNFYRFLPTAPP 172 QI T L+T ++L+ N++ + S+N +D L + NN + A Sbjct: 1778 ---QIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYN 1834 Query: 173 NVMSQADTVIL--DKSKITVPFLKHGF-----CENLDDICHSIKQMKEELQKSHDGEVAL 225 ++ + + + D+ K + L G +N + +++ ++L+ +G+V Sbjct: 1835 KILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKV-- 1892 Query: 226 TNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKL 285 + + P +N K ++ + K K E + L E + E+ L K+L Sbjct: 1893 ----EEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKE-----KEGEVFTLTKQL 1943 Query: 286 LPFRETVSKFHVHFCRKCKKLSKSEMH-------RGKKNEKNNKEIPITGKNITD----L 334 ++ +K +KL + M R ++EK +E+ ++ + + Sbjct: 1944 NTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYM 2003 Query: 335 KFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYL 394 + H +PR D ++ + R +L ++ + EK ++ ++ ++ I+ Sbjct: 2004 RAHQALPR------DSVVEDLHLQNR--YLQEK---LHALEKQFSKDTYSKPSISGIES- 2051 Query: 395 QNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQ 454 ++ + ++QK+ ++L SEN+ LK +++ L +V ++ + L +EK+ +Q Sbjct: 2052 DDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQ 2111 Query: 455 SKLS--KTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSK 512 KL + S + + E +K I G K + EK + E +Q+ +A L S+ Sbjct: 2112 RKLGHVRGSGRSGKTIPELEKTI-------GLMKKVVEK---VQRENEQLKKASGILTSE 2161 Query: 513 EHKTQSDMAIVNNENNRMSIEMEAMKTNI-LLIQDEKEMLEKKTHQLLKEKSSLGNELK- 570 + MA + EN ++ E+E +K ++ + E K T +++ E L ELK Sbjct: 2162 K------MANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKK 2215 Query: 571 -----------ESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQ 619 ++ LEI+ K +L +T + LQ E+ + ++ +S + Sbjct: 2216 ETDAAEKLRIAKNNLEILNEKMTVQLEETGKR--LQFAESRGPQLEGADSKSWKSIVVTR 2273 Query: 620 IMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEM---LSKMVMETKT 676 + E +++ ++T + + ++K EA+ + +++ ++ E + K V E Sbjct: 2274 MYETKLKELET-DIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAE 2332 Query: 677 DNQILKEELKK----------------HSQENIKFENSISRLTEDKILLENYVRSIENER 720 Q LK EL+ H E K ++ D L+ ++ +E + Sbjct: 2333 TEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQL 2392 Query: 721 DTLEFEMRHLQREYLSLSDKICNQHNDPS 749 + E +HL+ E L ++ ++ DPS Sbjct: 2393 KMSDLEKQHLKEEIKKLKKEL--ENFDPS 2419 Score = 66.2 bits (160), Expect = 1e-10 Identities = 103/548 (18%), Positives = 232/548 (42%), Gaps = 93/548 (16%) Query: 227 NELQTLQTDPD-------VHRNGKYDMSPIHQDKMNFIKEENLDG--NLNEDIKSKRISE 277 N + ++ DPD + N +S + +++ K+EN+ + + + + E Sbjct: 6 NWKEIMKVDPDDLPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQE 65 Query: 278 LEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFH 337 +E ++++ E +KF K KL +N E+ D +F Sbjct: 66 VELALEEVEKAGEEQAKFENQLKTKVMKL------------ENELEMAQQSAGGRDTRFL 113 Query: 338 SRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNY 397 L+Q E++D E+ E EK KVN EQ + + +N Sbjct: 114 RNEICQLEKQLEQKDRELEDMEK------------ELEKEKKVN---EQLALRNEEAEN- 157 Query: 398 LKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVE-------EK 450 + +L EN LK K + L Q + Y+KQ+ + E E Sbjct: 158 ---------ENSKLRRENKRLKKK-------NEQLCQDIIDYQKQIDSQKETLLSRRGED 201 Query: 451 STIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSL-EKQQMMEALDQL 509 S +S+LSK + L E + + ++ QN+ + KN++ S+ E ++M + +++ Sbjct: 202 SDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEM-RKNLEESVQEMEKMTDEYNRM 260 Query: 510 KSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKE-----MLEKKTHQLLKEKSS 564 K+ H+T + + + EN+ ++++ + T++L ++E++ + K + SS Sbjct: 261 KAIVHQTDNVIDQLKKENDHYQLQVQEL-TDLLKSKNEEDDPIMVAVNAKVEEWKLILSS 319 Query: 565 LGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMERE 624 +E+ E Q + L+EK + A+ + + K + L+ +QE + +++ + Sbjct: 320 KDDEIIEYQQMLHNLREKLKNAQLDAD---------KSNVMALQQGIQERDSQIKMLTEQ 370 Query: 625 IENIQTYQSTAEEN--FLQEIKNA----KSEASIYKNSLSEIGKECEMLSKMVMETKTDN 678 +E Y E+N ++++KN K +++ + + +I ++L + E + Sbjct: 371 VEQ---YTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTA 427 Query: 679 QILKEELKKHSQENIK-------FENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQ 731 ++ + + ++ +E ++ +E+ + L + + ++N I+ +E + + Sbjct: 428 ELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEIN 487 Query: 732 REYLSLSD 739 + L +SD Sbjct: 488 KLELKISD 495 Score = 64.3 bits (155), Expect = 4e-10 Identities = 98/478 (20%), Positives = 211/478 (44%), Gaps = 85/478 (17%) Query: 307 SKSEMHRGKKNEKNNKEIPITGKN--ITDLK----------FHSRVPRYTLSFLDQTKHE 354 + + HR +N+ E+ + G I+ LK +H ++ L L + Sbjct: 1306 NSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNREL 1365 Query: 355 MKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQN----YLKESVQIQKKVM- 409 +KDKE +L +IISE E+T ++S+ E+ V + ++ + + + V +++++ Sbjct: 1366 VKDKEEIKYL---NNIISEYERT--ISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDI 1420 Query: 410 --ELESENLNLKSKMK--------PLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSK 459 ++E LN K + P + L + ++ ++ ++E ++T +S K Sbjct: 1421 FDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEK 1480 Query: 460 TEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQL--SLEKQQMMEALDQLKSKEHKTQ 517 +E KE +++ N+L ++K + E ++L + E+++++ L + K E K+ Sbjct: 1481 LKE------KESALRLAEQNILS-RDKVINELRLRLPATAEREKLIAELGR-KEMEPKSH 1532 Query: 518 SDMAIVN----NENNRMSIEMEAMKTNILLIQ----DEKEMLEKKTHQL--------LKE 561 + I + N R++ + E +K L++ +++E+++K L L+ Sbjct: 1533 HTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQA 1592 Query: 562 KSSLG-------NELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQES 614 SSL + +K+S + K RLA+ EQ T+ + +++ + L+ Q+ Sbjct: 1593 DSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQ-TVAEQDDSLSSLLVKLKKVSQDL 1651 Query: 615 TAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMET 674 R+I E +++ + + +EN E+K K+E E L ++ ++ Sbjct: 1652 ERQREITELKVKEFENIKLQLQENHEDEVKKVKAEV--------------EDLKYLLDQS 1697 Query: 675 KTDNQILKEELKKHSQENIK-----FENSISRLTEDKILLENYVRSIENERDTLEFEM 727 + ++Q LK EL+ + N + N + RL L E +++ L EM Sbjct: 1698 QKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEM 1755 Score = 59.3 bits (142), Expect = 1e-08 Identities = 145/775 (18%), Positives = 297/775 (38%), Gaps = 145/775 (18%) Query: 44 AESENQIQPQSALKVLQQQLESFQAL--RMQTLQNVSMPTENQEENLSMEKSHHFEDSKT 101 A + ++Q Q K L++ ++ + + ++ + T+N + L E H+ Sbjct: 228 ANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHY------ 281 Query: 102 LHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYN 161 +L + L +S N ED + + +I S++ +I++ Sbjct: 282 ------QLQVQELTDLLKSKN------EEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQ 329 Query: 162 NFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDI---CHSIKQMKEELQKS 218 + N+ + LD K V L+ G E I ++Q +E++K+ Sbjct: 330 MLH--------NLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKN 381 Query: 219 HDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISEL 278 L NELQ + + + + KE L E ++ EL Sbjct: 382 TCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKEL 441 Query: 279 EALVKKLLPFRETVSKFH--VHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKF 336 +K+L + V V + CK K ++EI I K I L+ Sbjct: 442 VEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIR----------DREIEILTKEINKLEL 491 Query: 337 HSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQN 396 FLD+ + + +P + +TE +K Q Sbjct: 492 KIS------DFLDENEALRERVGLEP---------------KTMIDLTEFRNSKHLKQQQ 530 Query: 397 YLKESVQIQKKVMELESENLNLKSKMKPLI-----------FTTQSL-----IQKVETYE 440 Y E+ + K++ LE E L+LK K++ + TT+ L I + + Sbjct: 531 YRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRIS 590 Query: 441 KQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVL---QGQNKTLEEKNIQLSL 497 ++ +L+ K+ +++ SK E S+E +++ + + V+ Q + K L E+N QL Sbjct: 591 ERKLDLLSLKNMSEAQ-SKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEE 649 Query: 498 EKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEA------------MKTNILLIQ 545 +++++A+ +++ + +++ R+ +E+ +K + + Sbjct: 650 GMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLT 709 Query: 546 DEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAK------------------ 587 E L ++ + KE + +L ++ L+I L+++ L + Sbjct: 710 GRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGI 769 Query: 588 ---------TEQETLLQIIETV--KDEKL-NLETTLQESTAARQIMEREIENIQTYQSTA 635 ++ E L+ +++ + K++KL NLE +L++ R+ I+ QS Sbjct: 770 APSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLED-------YNRKFAVIRHQQSLL 822 Query: 636 EENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQIL------KEELKKHS 689 + +L E + K+E+ K E K + + + ++ K N +L +E+KK Sbjct: 823 YKEYLSEKETWKTESKTIK---EEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKIL 879 Query: 690 QENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQ 744 EN + + +K L+ Y +E ER L E + E LS+ ++C + Sbjct: 880 AENSRKITVLQ--VNEKSLIRQYTTLVELERQ-LRKENEKQKNELLSMEAEVCEK 931 Score = 59.3 bits (142), Expect = 1e-08 Identities = 95/437 (21%), Positives = 190/437 (43%), Gaps = 56/437 (12%) Query: 300 CRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDK- 358 C++ ++L K + +N + ++ K++ LK R + FL + K E++ K Sbjct: 2055 CQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKL 2114 Query: 359 ERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQI--QKKVMELESENL 416 + G I E EKT + ++ V K+Q LK++ I +K+ +E EN Sbjct: 2115 GHVRGSGRSGKTIPELEKTI---GLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENE 2171 Query: 417 NLKSKMKPL-IFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKII 475 LK++++ L L E+ K + ++ E ++ +L K E + E L+ K + Sbjct: 2172 KLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKK-ETDAAEKLRIAKNNL 2230 Query: 476 SKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMS-IEM 534 N + LEE +L + + QL+ + K+ + + ++ +E Sbjct: 2231 EILN--EKMTVQLEETGKRLQFAESRG----PQLEGADSKSWKSIVVTRMYETKLKELET 2284 Query: 535 EAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQ-----------LKEKE 583 + K N I D K+++++ T + ++K + NE E Q++I++ LK + Sbjct: 2285 DIAKKN-QSITDLKQLVKEATER--EQKVNKYNEDLEQQIKILKHVPEGAETEQGLKREL 2341 Query: 584 RLAKT-------EQETLLQIIETVKD---------------EKL-NLETTLQESTAARQI 620 ++ + E+ L+ IE KD EK+ +LET L+ S +Q Sbjct: 2342 QVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQH 2401 Query: 621 MEREIENIQTYQSTAEENFLQEIKNAK--SEASIYKNSLSEIGKECEMLSKMVMETKTDN 678 ++ EI+ ++ + +F +EI++ K + + KN L E ++ + LS+ + T Sbjct: 2402 LKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLE--EKVKKLSEQLGVELTSP 2459 Query: 679 QILKEELKKHSQENIKF 695 EE + + + F Sbjct: 2460 VAASEEFEDEEESPVNF 2476 Score = 58.2 bits (139), Expect = 3e-08 Identities = 120/577 (20%), Positives = 246/577 (42%), Gaps = 68/577 (11%) Query: 215 LQKSHDGEVALTN-ELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSK 273 LQK D V+L+ EL Q + KY + +D M + NL+ E+I K Sbjct: 949 LQKVVDNSVSLSELELANKQYN---ELTAKY-RDILQKDNMLVQRTSNLEHLECENISLK 1004 Query: 274 RISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITD 333 ++E++ K+L +E + + ++ K ++S M + KK+ N+ + I+ K IT Sbjct: 1005 E--QVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSIS-KKITM 1061 Query: 334 LKFHSRVPR----YTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVA 389 L+ R + + + +K E + F ++ K +++ + Sbjct: 1062 LEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELET--------KFAELTKINLDAQK 1113 Query: 390 KIQYLQNYLKESVQI------QKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQL 443 Q L++ L +SV +++++ELE + LK ++ L + ++VE Q Sbjct: 1114 VEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQ 1173 Query: 444 KNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISK---YNVLQGQNKTLEEKNIQLSLEKQ 500 ++ +E +++ +L + S E K +I+K +NV ++ ++ K Sbjct: 1174 QSRDKEVESLRMQLLDYQAQSDE-----KSLIAKLHQHNVSLQLSEATALGKLESITSKL 1228 Query: 501 QMMEALD-QLKSKEHKTQSDMAIVNNENN------RMSIEMEAMKTNILLIQDEKEMLEK 553 Q MEA + +L+ K + + + E R +I+ + + L ++E K Sbjct: 1229 QKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSK 1288 Query: 554 KTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEK-----LNL- 607 QL +K + E+K SQ E ++ K + + + L ++I T+KD K +N Sbjct: 1289 TMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWH 1348 Query: 608 ----ETTLQESTAARQIMEREIE------NIQTYQ---STAEENFLQEIKNAKSEASIYK 654 E LQE R++++ + E I Y+ S+ EE +Q+ K + + Sbjct: 1349 MKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWD 1408 Query: 655 NSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFEN----SISRLTED-KILL 709 ++ ++ ++ + E Q +E ++ N ++ ++ E+ +I+L Sbjct: 1409 QREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIIL 1468 Query: 710 ENYV--RSIENERDTLEFEMRHLQREYLSLSDKICNQ 744 E +S+E + E +R ++ LS DK+ N+ Sbjct: 1469 ETRATCKSLEEKLKEKESALRLAEQNILS-RDKVINE 1504 Score = 51.2 bits (121), Expect = 4e-06 Identities = 63/304 (20%), Positives = 132/304 (43%), Gaps = 32/304 (10%) Query: 457 LSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKT 516 L + EE + L K+ + Q + I SL K + E L+ E K Sbjct: 18 LPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVE-KA 76 Query: 517 QSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKK-----THQLLKEKSSLGNELKE 571 + A N+ +KT ++ +++E EM ++ T L E L +L++ Sbjct: 77 GEEQAKFENQ----------LKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQ 126 Query: 572 SQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTY 631 E+ ++++ K E L E ++E L +E+ ++ E+ ++I Y Sbjct: 127 KDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLR---RENKRLKKKNEQLCQDIIDY 183 Query: 632 QSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKM-----VMETKTDNQILKEELK 686 Q + + + + + E S Y++ LS+ K E++ + + E ++ +E++ Sbjct: 184 QKQIDSQ-KETLLSRRGEDSDYRSQLSK--KNYELIQYLDEIQTLTEANEKIEVQNQEMR 240 Query: 687 KHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSD--KICNQ 744 K+ +E+++ + ++T++ ++ V +N D L+ E H Q + L+D K N+ Sbjct: 241 KNLEESVQ---EMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNE 297 Query: 745 HNDP 748 +DP Sbjct: 298 EDDP 301 >gi|31982906 cingulin-like 1 [Homo sapiens] Length = 1302 Score = 80.5 bits (197), Expect = 6e-15 Identities = 88/402 (21%), Positives = 174/402 (43%), Gaps = 33/402 (8%) Query: 348 LDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKK 407 L Q +E K+ +K+GS +++ KVN V E KIQ L++ S Q + Sbjct: 546 LTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFE----KIQTLKSRAAGSAQGNNQ 601 Query: 408 VMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKEC 467 SE +L + L L ++++ K +N+ EE+ +++ L + E Sbjct: 602 ACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEK 661 Query: 468 LKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQ----MMEALDQLKSKEHKTQSDMAIV 523 ++E + + +G+ + E+ Q+ +E++Q + + DQL + S Sbjct: 662 VEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSE 721 Query: 524 NNENNRMSIEMEAMKTNI--LLI--QDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQL 579 + E + E+ K ++ LLI ++++++L K+ +L K +L E+ E+ +L Sbjct: 722 DREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKL 781 Query: 580 KEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENF 639 KE+ L + E+V++ N+E S + Q ++ Q EEN Sbjct: 782 KEQY------DAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQ---EEN- 831 Query: 640 LQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSI 699 E +SE E+ + L + + + K D KE LKK+ E + E ++ Sbjct: 832 --EKLQGRSE---------ELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEAL 880 Query: 700 SRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKI 741 +++ + R++ENE + + + +E LS+K+ Sbjct: 881 VHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKL 922 Score = 75.5 bits (184), Expect = 2e-13 Identities = 134/762 (17%), Positives = 317/762 (41%), Gaps = 97/762 (12%) Query: 51 QPQSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLS 110 QP KVL+ E Q + ++ ++ +EE + + ++ T S + Sbjct: 463 QPNIDGKVLET--EGSQESTVIRAPSLGAQSKKEEEVKTATATLMLQNRATATSPDSGAK 520 Query: 111 GDSVNSLPQSVNV---PSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFL 167 SV + P + N P + + LT +T+ + + + E S Sbjct: 521 KISVKTFPSASNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEGS------------- 567 Query: 168 PTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTN 227 T + + ++ +K + T+ G + + C+S ++K+ L++ + + Sbjct: 568 -TDNDDATKRKVNLVFEKIQ-TLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAE 625 Query: 228 ELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLP 287 + LQ + +N K + + + + N N ++ +R+ E E ++K L Sbjct: 626 LQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQ-QRLEESEGELRKNLE 684 Query: 288 FRETVSKFHVHFCRKCKKLSK--SEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTL 345 V + + L SEMH + K +++ G I +L + + L Sbjct: 685 ELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDRE-KGALIEELLQAKQDLQDLL 743 Query: 346 SFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQ-- 403 ++ + ++ +ER+ +K + +++ + EQ A++Q L+ ++E+ + Sbjct: 744 IAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNV 803 Query: 404 ----------------IQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLV 447 + +V L+ EN L+ + + L L +++E + Sbjct: 804 EVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAK 863 Query: 448 EEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEAL- 506 E + ++ + EE KE K+ +S L+ + + + Q + E++Q+ E L Sbjct: 864 ETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLK 923 Query: 507 ------DQLKSKEHKTQSDMAIVNNENNRMSIEM----EAMKTNILLIQDEKEMLEKKTH 556 +QL+ +++ +++ + ++ EM EA +T+ L +Q++ + ++K Sbjct: 924 EESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNR 983 Query: 557 QLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTA 616 + L E + +LKE LE EK RL + + ++++E +E + + E+ Sbjct: 984 RELAE---MQRQLKEKTLEA----EKSRLTAMKMQDEMRLME---EELRDYQRAQDEALT 1033 Query: 617 ARQIMEREIENIQTYQSTAEENFLQE----IKNAKSEASIYKNSLSEIGKECEMLSKMVM 672 RQ++E+ +++++ Y+ A+ + + +K + + S + L E ++LS+ + Sbjct: 1034 KRQLLEQTLKDLE-YELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERIS 1092 Query: 673 ETKTDNQILKEEL--KKHSQENIKFEN-SISRLTED---KIL------------------ 708 ++ + L+ EL ++ ++++++ + S+ R +D +I+ Sbjct: 1093 RSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQME 1152 Query: 709 -----LENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQH 745 LE+ + S E +R L+ R L+R+ L ++ ++H Sbjct: 1153 ARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEH 1194 Score = 68.6 bits (166), Expect = 2e-11 Identities = 152/793 (19%), Positives = 317/793 (39%), Gaps = 104/793 (13%) Query: 21 SKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMP 80 S+ S++G ++ S +E + E ++++ + A LQ+QL+ L ++ QN+ Sbjct: 590 SRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVA--ELQRQLQ----LEVKNQQNIKEE 643 Query: 81 TENQEENLSMEKSHH---FEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRT 137 E NL +S H E++ TL E+ G+ +L + V + Sbjct: 644 RERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQ-------- 695 Query: 138 STDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGF 197 H +E D+ + + L +A + + +I + + Sbjct: 696 -----------HQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAK-------- 736 Query: 198 CENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFI 257 ++L D+ + ++ ++ L+K AL L K ++S H +M+ + Sbjct: 737 -QDLQDLLIAKEEQEDLLRKRERELTALKGAL-------------KEEVSS-HDQEMDKL 781 Query: 258 KEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKN 317 KE+ D L +S + E V+ L T + + K L + ++ Sbjct: 782 KEQ-YDAELQALRES--VEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRS 838 Query: 318 EKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKT 377 E+ + + + I DLK + TL K+E + ++ + LV E E Sbjct: 839 EELERRVAQLQRQIEDLKGDEAKAKETLK-----KYEGEIRQLEEALVHARK--EEKEAV 891 Query: 378 SKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVE 437 S ++ + A L +E Q+ +K+ E + L+ + L + +E Sbjct: 892 SARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIE 951 Query: 438 TYEKQLKNLVEEKST----IQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNI 493 +K++ ++VE T +Q++L + +E ++ L E ++ Q + KTLE + Sbjct: 952 KLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQR--------QLKEKTLEAEKS 1003 Query: 494 QLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEK 553 +L+ K Q L + + ++++ D A+ R +E ++D + LE Sbjct: 1004 RLTAMKMQDEMRLMEEELRDYQRAQDEAL----TKRQLLEQ--------TLKDLEYELEA 1051 Query: 554 KTHQLLKEKSSLGNEL--KESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTL 611 K+H L ++S L ++ K SQLE ++L+E+ + + L + I +++ L L Sbjct: 1052 KSH-LKDDRSRLVKQMEDKVSQLE-MELEEE----RNNSDLLSERISRSREQMEQLRNEL 1105 Query: 612 QESTAARQIMEREIENIQTYQSTAEENFLQ---EIKNAKSEASIYKNS-LSEIGKECEML 667 + AARQ +E + +++ + + +++K + + ++E+ E Sbjct: 1106 LQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESE 1165 Query: 668 SKMVMETKTDNQILKEELK----KHSQENIKFENSISRLTEDKILLENYVRSIENERDTL 723 + + N+ L+ ++K + E++ + +L+ ++ V E E D L Sbjct: 1166 ERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRL 1225 Query: 724 EFEMRHLQR---EYLSLSDKICNQHNDPSKTTYISRREKFHFDNYTHEDTSSPQSRPLAS 780 E + LQR E + +++ + Q N K + + D+ +D S L Sbjct: 1226 ESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLPSKVLDDMDDDDDLSTDGGSLYE 1285 Query: 781 DLKGYFKVKDRTL 793 Y KD T+ Sbjct: 1286 APVSYTFSKDSTV 1298 Score = 37.0 bits (84), Expect = 0.072 Identities = 38/191 (19%), Positives = 77/191 (40%), Gaps = 20/191 (10%) Query: 581 EKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEE--- 637 ++E +T +ET QI+ E + A ++ + E IQT +S A Sbjct: 543 QQELTQQTNEETAKQILYNYLKEG-----STDNDDATKRKVNLVFEKIQTLKSRAAGSAQ 597 Query: 638 ------NFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILK---EELKKH 688 N E+K+ + S ++E+ ++ ++ K K + + ++ EEL+ Sbjct: 598 GNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQ 657 Query: 689 SQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDP 748 E ++ +++ + E+ E +R E ++ E Q E L D++ H++ Sbjct: 658 HNEKVEENSTLQQRLEES---EGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDEL 714 Query: 749 SKTTYISRREK 759 REK Sbjct: 715 DSAKRSEDREK 725 Score = 32.7 bits (73), Expect = 1.4 Identities = 69/352 (19%), Positives = 144/352 (40%), Gaps = 40/352 (11%) Query: 404 IQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEY 463 I KV+E E + + P + ++V+T L +++ ++T S S ++ Sbjct: 466 IDGKVLETEGSQESTVIRA-PSLGAQSKKEEEVKTATATL--MLQNRATATSPDSGAKKI 522 Query: 464 SKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIV 523 S + + ++L+GQ + ++ N + + KQ + L KE T +D A Sbjct: 523 SVKTFPSASNTQATPDLLKGQQELTQQTNEETA--KQILYNYL-----KEGSTDNDDA-T 574 Query: 524 NNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQ---LLKEKSSLGNELKESQLEIIQLK 580 + N + +++ +K+ T + LL++KS L E+ E Q ++ QL+ Sbjct: 575 KRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQL-QLE 633 Query: 581 EKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEEN-- 638 K + + +K+E+ + L+E R ++E T Q EE+ Sbjct: 634 VKNQ-------------QNIKEERERMRANLEE---LRSQHNEKVEENSTLQQRLEESEG 677 Query: 639 ----FLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIK 694 L+E+ K E ++ + ++ + LS+M E + + E +E ++ Sbjct: 678 ELRKNLEELFQVKMEREQHQTEIRDLQ---DQLSEMHDELDSAKRSEDREKGALIEELLQ 734 Query: 695 FENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHN 746 + + L K E+ +R E E L+ ++ + DK+ Q++ Sbjct: 735 AKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYD 786 >gi|46049114 M-phase phosphoprotein 1 [Homo sapiens] Length = 1780 Score = 80.5 bits (197), Expect = 6e-15 Identities = 124/598 (20%), Positives = 248/598 (41%), Gaps = 85/598 (14%) Query: 177 QADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQT----- 231 Q + + +K +T+ N D + K + Q+ + + L+NE++T Sbjct: 876 QQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSI 935 Query: 232 ----------------LQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNL-----NEDI 270 L+T V + D+ + +D N +E+NL N+ + Sbjct: 936 TNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNL-RDLSNGSEEDNLPNTQLDLLGNDYL 994 Query: 271 KSKRISELEALVKKLLPFRETVSKFHVHF------CRKCKKLSKSEMHRGKKNEKNNKEI 324 SK++ E P RE + FH C++ K S + H+ ++ E+ +++ Sbjct: 995 VSKQVKEYRIQE----PNRE--NSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKL 1048 Query: 325 PITGKNITDLKFHSRVPRYTLSFLDQTKHEMKD---KERQPFLVKQGSIISENEKTS--K 379 K D + L + +H+ +D KE++ + + + E T + Sbjct: 1049 QAEVKGYKDEN----------NRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQ 1098 Query: 380 VNSVTEQCVAKIQYLQNYL--KESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVE 437 + V E A + Q K ++ + ++E + + +K++ I +S+I K+E Sbjct: 1099 IQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLE 1158 Query: 438 TYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSL 497 +NL E + +Q + T++ + + LK ++I N LQ L+ K + Sbjct: 1159 ------RNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEET 1212 Query: 498 EKQQMMEALDQLKSKEHKTQS----------DMAIVNNENNRMSIEMEAMKTNILLIQDE 547 +Q+ + ++L + +TQ+ D A + + +++ ++ + +++DE Sbjct: 1213 NRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDE 1272 Query: 548 KEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNL 607 ++L K ++L K+K+ EL Q I QLKE+ K E E + Q KD LN+ Sbjct: 1273 DKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVE-EAIQQYERACKD--LNV 1329 Query: 608 ETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEML 667 + + E R +E E E Q Q E L+E++ +E +K +++ + Sbjct: 1330 KEKIIED--MRMTLE-EQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQR 1386 Query: 668 SKMVMETKTD----NQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERD 721 S E TD L++EL++ Q K+ + E+K++L + EN R+ Sbjct: 1387 SNKEHENNTDVLGKLTNLQDELQESEQ---KYNADRKKWLEEKMMLITQAKEAENIRN 1441 Score = 65.1 bits (157), Expect = 2e-10 Identities = 116/572 (20%), Positives = 236/572 (41%), Gaps = 48/572 (8%) Query: 204 ICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLD 263 IC+ ++ ++ + E NE + Q +P + + S I +D+ K E + Sbjct: 772 ICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQK---KSEEVR 828 Query: 264 GNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKE 323 N+ E I+ R+ L+ + L F T+ + + +L+K +H ++ + K+ Sbjct: 829 PNIAE-IEDIRV--LQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKK 885 Query: 324 IPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSV 383 K + ++ + Y ++ + + K++E++ ++K + I E S N+V Sbjct: 886 NLTLSKEVQQIQSN-----YDIAIAELHVQKSKNQEQEEKIMKLSNEI-ETATRSITNNV 939 Query: 384 TEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQL 443 ++ + + + +SV + L +L+ S+ L T L+ KQ+ Sbjct: 940 SQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQV 999 Query: 444 KNL-VEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQM 502 K ++E + S S E +EC K+I+ + Q + LE++ +L E + Sbjct: 1000 KEYRIQEPNRENSFHSSIEAIWEEC----KEIVKASSKKSHQIEELEQQIEKLQAEVKGY 1055 Query: 503 MEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEK 562 + ++LK KEHK Q D+ +K LIQ KE L++K L + Sbjct: 1056 KDENNRLKEKEHKNQDDL----------------LKEKETLIQQLKEELQEKNVTLDVQI 1099 Query: 563 SSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIME 622 + E K + E+ Q + E ET+L+ + LE + E + +E Sbjct: 1100 QHVV-EGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLE 1158 Query: 623 REIENIQTYQSTAEENF----LQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDN 678 R ++ Q + + +N ++E+K K E + N+L ++ ++ + + + Sbjct: 1159 RNLKEFQEHLQDSVKNTKDLNVKELK-LKEEITQLTNNLQDMKHLLQLKEEEEETNRQET 1217 Query: 679 QILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLS 738 + LKEEL S + + R ED L+ + + + ++ E+ ++ E L Sbjct: 1218 EKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLR 1277 Query: 739 DKI---------CNQHNDPSKTTYISRREKFH 761 KI C+Q D + T +E+ + Sbjct: 1278 IKINELEKKKNQCSQELDMKQRTIQQLKEQLN 1309 Score = 58.5 bits (140), Expect = 2e-08 Identities = 136/683 (19%), Positives = 275/683 (40%), Gaps = 81/683 (11%) Query: 101 TLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNY 160 TL+S +EKL G +S Q V++ S +S+ L ++ +T + N + E+ D+++ Sbjct: 484 TLNSSQEKLFGPVKSS--QDVSLDSNSNSK-ILNVKRATISWE-NSLEDLMEDEDLVEEL 539 Query: 161 NNFYRFLPTAPPNVMSQADTVILDKS-KITVPFLKHGFCENLDDICHSIKQ-MKEELQKS 218 N NV ++ LDK+ + F+ H L D+ +K+ + E ++ Sbjct: 540 EN-----AEETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLKKKLINEKKEK 594 Query: 219 HDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLN----------- 267 E + E+ T R + + + + + I EEN + L Sbjct: 595 LTLEFKIREEVTQEFTQYWAQREADFKETLLQERE---ILEENAERRLAIFKDLVGKCDT 651 Query: 268 -----EDIKSKRISELEALVKKLLPFRET---VSKFHVHFCRKCKKLSKSEMHRG---KK 316 +DI + ++ EA L F + ++K + ++L K E ++ Sbjct: 652 REEAAKDICATKVETEEATACLELKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQE 711 Query: 317 NEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMK------DKERQPFLVKQGSI 370 E +NK+I + I +L T++ K M+ DK L+ + Sbjct: 712 LETSNKKIITQNQRIKELINIIDQKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKL 771 Query: 371 ISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQ 430 I +S ++ C + + +N L++ KK S + K + Sbjct: 772 ICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNI 831 Query: 431 SLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEE 490 + I+ + ++ + L TI+++L +E E K+ Q + E+ Sbjct: 832 AEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVH-------FQQELSLSEK 884 Query: 491 KNIQLSLEKQQMME----ALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQD 546 KN+ LS E QQ+ A+ +L ++ K Q + +N + ++ N+ I Sbjct: 885 KNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQI-- 942 Query: 547 EKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLK------EKERLAKTEQETL---LQII 597 K H + E +L + + S ++++ L+ E++ L T+ + L + Sbjct: 943 ------KLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVS 996 Query: 598 ETVKDEKL---NLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYK 654 + VK+ ++ N E + S A +EI + +S E Q+I+ ++E YK Sbjct: 997 KQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYK 1056 Query: 655 NSLSEI-GKECEMLSKMVMETKTDNQILKEELKKHS-------QENIKFENSISRLTEDK 706 + + + KE + ++ E +T Q LKEEL++ + Q ++ + ++S LT+ Sbjct: 1057 DENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGV 1116 Query: 707 ILLENYVRSIENERDTLEFEMRH 729 + ++ +E +T + E H Sbjct: 1117 TCYKAKIKELETILETQKVECSH 1139 Score = 48.1 bits (113), Expect = 3e-05 Identities = 85/410 (20%), Positives = 179/410 (43%), Gaps = 59/410 (14%) Query: 380 VNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETY 439 +NS E+ ++ Q+ +S K++ ++ ++ ++ ++ L+ + L++++E Sbjct: 485 LNSSQEKLFGPVKSSQDVSLDS-NSNSKILNVKRATISWENSLEDLM-EDEDLVEELENA 542 Query: 440 EKQLKNLVEEKSTIQSKLSKTEEYSKECL--KEFKKIISKYNVLQGQNKTLEEKNIQLSL 497 E + +N+ E + L KT E +K + +E +K++ L+ K + EK +L+L Sbjct: 543 E-ETQNV--ETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLK--KKLINEKKEKLTL 597 Query: 498 EKQQMMEALDQLKS---------KEHKTQSDMAIVNNENNRMSI------EMEAMKTNIL 542 E + E + KE Q + N R++I + + + Sbjct: 598 EFKIREEVTQEFTQYWAQREADFKETLLQEREILEENAERRLAIFKDLVGKCDTREEAAK 657 Query: 543 LIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKD 602 I K E+ T L + + + EL +++ E+I+ KE+ + + E ++L+Q +ET Sbjct: 658 DICATKVETEEATACLELKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNK 717 Query: 603 EKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYK----NSLS 658 + + ++E E I Q +S E F K S I N Sbjct: 718 KIITQNQRIKELINIIDQKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETV 777 Query: 659 EIGKECEMLSKMVMETK--TDNQILKEE-------------LKKHSQENIKFENSISRLT 703 E+ K+ + SK+ E K +N++ ++E + + +++ + +I+ + Sbjct: 778 EVPKDSK--SKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIE 835 Query: 704 EDKILLEN------YVRSIEN-------ERDTLEFEMRHLQREYLSLSDK 740 + ++L EN ++ +IEN E+ L ++ H Q+E LSLS+K Sbjct: 836 DIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQE-LSLSEK 884 Score = 44.3 bits (103), Expect = 5e-04 Identities = 122/695 (17%), Positives = 273/695 (39%), Gaps = 125/695 (17%) Query: 50 IQPQSALKVLQQQLESFQALRMQTLQN---VSMPTENQEENLSMEKSHHFEDSKTLHSV- 105 ++ +S + L++ L+ FQ +++N +++ +E ++ + +++ +D K L + Sbjct: 1148 LEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEIT-QLTNNLQDMKHLLQLK 1206 Query: 106 --EEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNF 163 EE+ + L + ++ S T NL +++ + +D+ + + Sbjct: 1207 EEEEETNRQETEKLKEELSASS-----------ARTQNLKADLQRKEEDYADLKEKLTDA 1255 Query: 164 YRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFC-ENLDDICHSIKQMKEELQKSHDGE 222 + + V D L + KI K C + LD +I+Q+KE+L E Sbjct: 1256 KKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEE 1315 Query: 223 VALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALV 282 E + D++ K I +D ++E+ + + ++ E+E L Sbjct: 1316 AIQQYE----RACKDLNVKEK-----IIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLA 1366 Query: 283 KKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPR 342 +L ++E KC L R K +NN ++ GK +T+L+ Sbjct: 1367 TELEKWKE-----------KCNDLETKNNQRSNKEHENNTDV--LGK-LTNLQDEL---- 1408 Query: 343 YTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESV 402 Q + + +R+ +L ++ +I++ ++ + + + ++ Y ++ Sbjct: 1409 -------QESEQKYNADRKKWLEEKMMLITQAKEAENIRN---------KEMKKYAEDRE 1452 Query: 403 QIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEE 462 + K+ E+E L K L + Q V E QLK L I S + K E Sbjct: 1453 RFFKQQNEMEILTAQLTEKDSDLQKWREERDQLVAALEIQLKAL------ISSNVQKDNE 1506 Query: 463 YSKECLKEFKKIISKYNVLQGQNKTLEEKNI------QLSLEKQQMMEALDQLKSKEHKT 516 +++ K+IIS+ + ++ Q ++ K I +L E + + K ++ Sbjct: 1507 -----IEQLKRIISETSKIETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKIEDGSV 1561 Query: 517 QSDMAIVNNENNR--------MSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNE 568 D V+ EN++ + I+ ++ N + ++ T ++ K + NE Sbjct: 1562 VLDSCEVSTENDQSTRFPKPELEIQFTPLQPNKMAVK-HPGCTTPVTVKIPKARKRKSNE 1620 Query: 569 LKESQLEIIQLK--------------EKERLAKTEQETLLQ--------IIETVKDEKLN 606 ++E ++ K ++ K EQ+ ++ + +N Sbjct: 1621 MEEDLVKCENKKNATPRTNLKFPISDDRNSSVKKEQKVAIRPSSKKTYSLRSQASIIGVN 1680 Query: 607 LETTLQESTAAR---------QIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSL 657 L T +E T + I++ + + I S+++ + ++ K S+ K L Sbjct: 1681 LATKKKEGTLQKFGDFLQHSPSILQSKAKKIIETMSSSKLSNVEASKENVSQPKRAKRKL 1740 Query: 658 --SEIGKECEMLSKMVM----ETKTDNQILKEELK 686 SEI ++ ++++ ++D+QI+K L+ Sbjct: 1741 YTSEISSPIDISGQVILMDQKMKESDHQIIKRRLR 1775 >gi|87298937 centrosomal protein 110kDa [Homo sapiens] Length = 2325 Score = 79.7 bits (195), Expect = 1e-14 Identities = 132/597 (22%), Positives = 256/597 (42%), Gaps = 104/597 (17%) Query: 207 SIKQMKEELQKSHDGEVALTNELQTLQTD-PDVHRNGKYDMSPIHQDKMNFIKEENLDGN 265 S +Q ++E+++ H L E ++L+ + ++HR + Q + +FI + N++ Sbjct: 1348 SKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQK-----RQQQKDFI-DGNVESL 1401 Query: 266 LNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKL---SKSEMHRGKKNEKN-- 320 + E K + E +V ++ +T+ K R+ +L ++SE+ K+ KN Sbjct: 1402 MTELEIEKSLKHHEDIVDEIECIEKTLLKRRSEL-READRLLAEAESELSCTKEKTKNAV 1460 Query: 321 ------NKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKD--KERQPFLVKQGSIIS 372 + + T + +L+ ++ L DQ ++ K+ + +KQ I+ Sbjct: 1461 EKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILK 1520 Query: 373 ENEKTSKVNSVTEQCVAK--------IQYLQN--------------YLKES-VQIQKKVM 409 E K QC++K +Q LQ LKES V +Q K Sbjct: 1521 EINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRA 1580 Query: 410 ELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTE-EYSKEC- 467 ELE + S+ + + + L K E ++V+ K+ +Q L E E +++C Sbjct: 1581 ELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCN 1640 Query: 468 -LKEFKKIISKYNVLQGQ-NKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNN 525 ++E K ++ + + +G+ N + E+ QL+L KQ++ K + ++ +V Sbjct: 1641 HIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEI-----------EKEEENLQVVLR 1689 Query: 526 ENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERL 585 + ++ E++ NIL +ML+ + H+L K L ++ + S+LE Q+ E Sbjct: 1690 QMSKHKTELK----NIL------DMLQLENHELQGLK--LQHDQRVSELEKTQVAVLEE- 1736 Query: 586 AKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKN 645 K E E L QI + K E +Q++ER+ I+ + TAE LQ Sbjct: 1737 -KLELENLQQISQQQKGE----------IEWQKQLLERDKREIE--RMTAESRALQSCVE 1783 Query: 646 AKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQIL--KEELKKHSQENI--------KF 695 S+ ++ ++C++ K + +TK ++L EE K Q N+ K Sbjct: 1784 CLSKEK------EDLQEKCDIWEKKLAQTK---RVLAAAEENSKMEQSNLEKLELNVRKL 1834 Query: 696 ENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTT 752 + + +L DK+ L N + +++ + + LQ E ++ D + D TT Sbjct: 1835 QQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTT 1891 Score = 75.1 bits (183), Expect = 2e-13 Identities = 94/498 (18%), Positives = 220/498 (44%), Gaps = 76/498 (15%) Query: 271 KSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKN 330 K I E+++L+++L F++ + +V + +L+ + K+ E + K+ Sbjct: 1638 KCNHIREVKSLLEEL-SFQK--GELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKH 1694 Query: 331 ITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAK 390 T+LK + LD ++++ E Q ++ +SE EKT + + Sbjct: 1695 KTELK----------NILDML--QLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELEN 1742 Query: 391 IQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEK 450 +Q + K ++ QK+++E + K +++ + +++L VE K+ ++L E+ Sbjct: 1743 LQQISQQQKGEIEWQKQLLERD------KREIERMTAESRALQSCVECLSKEKEDLQEKC 1796 Query: 451 STIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQ-LSLEKQQMMEALDQL 509 + KL++T K++++ +N +E+ N++ L L +++ + LDQL Sbjct: 1797 DIWEKKLAQT-----------KRVLAAAE----ENSKMEQSNLEKLELNVRKLQQELDQL 1841 Query: 510 KSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQD-----EKEMLEKKTHQ--LLKEK 562 + +D++ + + + +++ + +QD ++++L HQ LL E+ Sbjct: 1842 NRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQ 1901 Query: 563 SSL----------------GNELKESQLEIIQLK-EKERLAKTEQETLLQIIETVKDEKL 605 + L E K+ QL+++Q + E+ +L +QE + Q ++ ++ + Sbjct: 1902 TRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESE- 1960 Query: 606 NLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECE 665 E+ L+ S + + ++E T Q + + L ++ A+ +L E + CE Sbjct: 1961 --ESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERV----RTLQEEERWCE 2014 Query: 666 MLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYV--------RSIE 717 L K + +TK +++L + S E + + + D LL N + + Sbjct: 2015 SLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVA 2074 Query: 718 NERDTLEFEMRHLQREYL 735 + ++ L+ + L++ L Sbjct: 2075 SLKEALKIQRSQLEKNLL 2092 Score = 54.3 bits (129), Expect = 4e-07 Identities = 96/471 (20%), Positives = 186/471 (39%), Gaps = 83/471 (17%) Query: 326 ITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDK--ERQPFLVKQGSIISENEKTSKVNSV 383 + G+ +T R++L +++ + +++ K E + KQ + E + K+N Sbjct: 250 LEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKS 309 Query: 384 TEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQL 443 LKE +QK+ E +LN K+++ Q I+ +KQ Sbjct: 310 --------------LKEEAMLQKQSCEELKSDLNTKNEL-----LKQKTIELTRACQKQY 350 Query: 444 KNLVEEKS--TIQSKLSKTEEYSKECLKEFK---------KIISKYNVLQGQNKTLEEKN 492 + L +E + I +K Y E + K K K N+ ++ ++ Sbjct: 351 E-LEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQ 409 Query: 493 IQLSLEKQQMMEAL--DQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEM 550 + ++K + E L D + + H T D + + E ++ A +T + + DE Sbjct: 410 A-VQIKKMEPDEQLRNDHMNLRGH-TPLDTQLEDKEK-----KISAAQTRLSELHDE--- 459 Query: 551 LEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETT 610 +EK Q+L+ + QL+ I K+ L K + LQ++ ++ E L+LE Sbjct: 460 IEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYK-QLSGRLQLVNKLRQEALDLELQ 518 Query: 611 LQESTAARQIMEREIENIQTY-----QSTAEENFLQEIKNAKSEASIYKNS--------- 656 +++ ++EI+++Q + + ++ K+ K + N Sbjct: 519 MEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRL 578 Query: 657 ---LSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENI----------------KFEN 697 LS I KE E + K + E T+ QI E K E + + +N Sbjct: 579 DEILSRIAKETEEI-KDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQN 637 Query: 698 SISRLTEDKILLENYVRSIENERDTLE---FEMRHLQREYLSLSDKICNQH 745 +L ++K L + +E ERD LE + ++++E L + QH Sbjct: 638 ECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQH 688 Score = 53.5 bits (127), Expect = 7e-07 Identities = 142/739 (19%), Positives = 295/739 (39%), Gaps = 151/739 (20%) Query: 46 SENQIQPQSALKVLQQQLESFQALRMQTLQNVSMPTENQ----EENLSMEKSHHFEDSKT 101 S+++ + ++ L +LQ + Q L++Q Q VS + Q EE L +E Sbjct: 1692 SKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELEN--------- 1742 Query: 102 LHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDN---LSSNIIIHPSENSDILK 158 L + ++ G+ + Q+ D + T L S + E D+ + Sbjct: 1743 LQQISQQQKGE--------IEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQE 1794 Query: 159 NYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKS 218 + + + L + + + +++S NL+ + +++++++EL + Sbjct: 1795 KCDIWEKKLAQTKRVLAAAEENSKMEQS-------------NLEKLELNVRKLQQELDQL 1841 Query: 219 HDGEVALTNELQTLQTDPDVHR---NGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRI 275 + +++L N++ +Q R N + QD +N K++ L ++D+ + Sbjct: 1842 NRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDV---LL 1898 Query: 276 SELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLK 335 SE L K + E ++F C+ K+ E +++ + I + K Sbjct: 1899 SEQTRLQKDI---SEWANRF-----EDCQ----------KEEETKQQQLQVLQNEIEENK 1940 Query: 336 FHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEK--TSKVNSVTEQCVAKIQY 393 ++ + + F + KER+ SE K TSKV Sbjct: 1941 L--KLVQQEMMF------QRLQKERE----------SEESKLETSKVT------------ 1970 Query: 394 LQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTI 453 ++++ +LE E + KSK+ ++ KV E++++ L EE+ Sbjct: 1971 ----------LKEQQHQLEKELTDQKSKL-------DQVLSKVLAAEERVRTLQEEERWC 2013 Query: 454 QSKLSKTEEYSKECLKE-FKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMM----EALDQ 508 +S L KT +K L E ++++ K L K + SL + Q + +A Q Sbjct: 2014 ES-LEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQ 2072 Query: 509 LKS-----KEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKS 563 + S K ++Q + ++ + I+ E M T L+ QD E + +L+KE + Sbjct: 2073 VASLKEALKIQRSQLEKNLLEQKQENSCIQKE-MATIELVAQDNHE----RARRLMKELN 2127 Query: 564 SLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDE----KLNLETTLQESTAARQ 619 + E E + ++ K+ ER + + + VKDE NL L E A + Sbjct: 2128 QMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLE 2187 Query: 620 IMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQ 679 + EN++ + +EN + E K + S++ +M+ + Sbjct: 2188 AILERNENLEGELESLKENLPFTMNEGPFEE---KLNFSQV---------HIMDEHWRGE 2235 Query: 680 ILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSD 739 L+E+L +H ++ +K + + ++L I+ +R T E + L+R+ +L + Sbjct: 2236 ALREKL-RHREDRLKAQLRHCMSKQAEVL-------IKGKRQT-EGTLHSLRRQVDALGE 2286 Query: 740 KICNQHNDPSKTTYISRRE 758 + + D + + +S+ E Sbjct: 2287 LVTSTSADSASSPSLSQLE 2305 Score = 52.8 bits (125), Expect = 1e-06 Identities = 128/724 (17%), Positives = 284/724 (39%), Gaps = 90/724 (12%) Query: 60 QQQLESFQALRMQTLQNVSMPTEN---QEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNS 116 Q + E+F+ ++ ++ + E + E L +++ E+ K + + L +++ Sbjct: 258 QDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQ 317 Query: 117 LPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMS 176 + S +++++ L L+ T L+ + L+ FY+ P Sbjct: 318 KQSCEELKSDLNTKNEL-LKQKTIELT-----RACQKQYELEQELAFYKIDAKFEPLNYY 371 Query: 177 QADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDP 236 ++ +DK+ P++ + K + + + +Q + +P Sbjct: 372 PSEYAEIDKAPDESPYIGKS-------------RYKRNMFATESYIIDSAQAVQIKKMEP 418 Query: 237 DVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFH 296 D + D MN LD L + K K+IS + + +L + + K Sbjct: 419 D---------EQLRNDHMNLRGHTPLDTQLED--KEKKISAAQTRLSEL---HDEIEKAE 464 Query: 297 VHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMK 356 R ++ + E K+I GK++ + R L +++ + E Sbjct: 465 QQILRATEEFKQLE------EAIQLKKISEAGKDLLYKQLSGR-----LQLVNKLRQEAL 513 Query: 357 DKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENL 416 D E Q + KQ I+ +K K + + +++K QK E + + + Sbjct: 514 DLELQ--MEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKA----QKSGKEQQLDIM 567 Query: 417 NLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIIS 476 N + + L ++ ++ +++K+L E+ + + +++ E K+ + Sbjct: 568 N--KQYQQLESRLDEILSRIAKETEEIKDLEEQLT--EGQIAANEALKKDLEGVISGLQE 623 Query: 477 KYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSI---- 532 ++GQ + + +L EK+ +++ L +++ + + Q ++ ++ EN R + Sbjct: 624 YLGTIKGQATQAQNECRKLRDEKETLLQRLTEVE--QERDQLEIVAMDAENMRKELAELE 681 Query: 533 ----EMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKT 588 E + ++ Q + E + L + + N+LKE +L++ RL + Sbjct: 682 SALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKE------ELEKVTRLTQL 735 Query: 589 EQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNA-K 647 EQ L +E E+ L+ L ++ + E+E EN + + A+ LQ+ N K Sbjct: 736 EQSALQAELEK---ERQALKNALGKAQFSE---EKEQENSELH---AKLKHLQDDNNLLK 786 Query: 648 SEASIYKNSLSEIGKEC---EMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTE 704 + ++N L+ + E ++ V E + ++ E+ HS ++ S++ L Sbjct: 787 QQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDV-LGKSLADL-- 843 Query: 705 DKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRREKFHFDN 764 K E RS + ERD + R LQ E +K+ + + + + +FD Sbjct: 844 QKQFSEILARS-KWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDK 902 Query: 765 YTHE 768 HE Sbjct: 903 RQHE 906 Score = 52.0 bits (123), Expect = 2e-06 Identities = 101/554 (18%), Positives = 236/554 (42%), Gaps = 81/554 (14%) Query: 252 DKMNFIKEENLDGNL--NEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKS 309 +++ ++E+ +G + NE +K +LE ++ L + T+ +C+KL Sbjct: 590 EEIKDLEEQLTEGQIAANEALKK----DLEGVISGLQEYLGTIKGQATQAQNECRKLRDE 645 Query: 310 E---MHRGKKNEKNNKEIPITG-------KNITDLKFHSRVPRYTLSFLDQTKHEMKDKE 359 + + R + E+ ++ I K + +L+ + + L QT+ ++ E Sbjct: 646 KETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYE 705 Query: 360 RQPFL------VKQGSIISENEKTSKVNSVTEQCV-AKIQYLQNYLKESVQIQKKVMELE 412 + + + E EK +++ + + + A+++ + LK ++ + E E Sbjct: 706 AELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKE 765 Query: 413 SENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFK 472 EN L +K+K L L Q+++ ++ L ++V+ + ++ +E ++ LK Sbjct: 766 QENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRK-LKLGT 824 Query: 473 KIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNE------ 526 ++ ++ K+L + Q S + D+ + +E K Q +MA+ + Sbjct: 825 GEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQE 884 Query: 527 ----------NNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLE- 575 RM+ + + I +++E L++ + + + +L+E+ E Sbjct: 885 EFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEK 944 Query: 576 ---IIQLKEKERLAKTE----QETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENI 628 + QL+E E+ K E QE + + + +K K + T+ + +TA I + +++++ Sbjct: 945 ERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSL 1004 Query: 629 -----QTYQSTAEE------------NFLQEIKNAKSEASIYKNSLSEIGKECEM-LSKM 670 + Q AEE +++ A++E + +N L + G++ + + K Sbjct: 1005 HGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKT 1064 Query: 671 VMETKTDNQILKEELKKHSQENIKFENSISRL--------TEDKILLENYVRSIENERDT 722 + T ++Q+L+ E + E + E I+RL +++K EN + I R Sbjct: 1065 GVGTGANSQVLEIEKLNETMERQRTE--IARLQNVLDLTGSDNKGGFENVLEEIAELRRE 1122 Query: 723 LEFEMRHLQREYLS 736 + + Q +Y+S Sbjct: 1123 VSY-----QNDYIS 1131 Score = 42.0 bits (97), Expect = 0.002 Identities = 65/334 (19%), Positives = 141/334 (42%), Gaps = 16/334 (4%) Query: 447 VEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQN-KTLEE--KNIQLSLEKQQMM 503 V E +++++S+ E+ + LK K+ + Q+ K +EE NI L++++ + Sbjct: 1315 VPEHHNLENEVSRLEDIMQH-LKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSL 1373 Query: 504 EA-LDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKT--NILLIQDEKEMLEKKTHQLLK 560 E +++L K Q ++ + E+E K+ + I DE E +EK LLK Sbjct: 1374 ECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEK---TLLK 1430 Query: 561 EKSSLGNE---LKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAA 617 +S L L E++ E+ KEK + A + + + + + LE QE+ Sbjct: 1431 RRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVN 1490 Query: 618 RQIMEREIENIQTYQSTAEENFLQE---IKNAKSEASIYKNSLSEIGKECEMLSKMVMET 674 ++++ ++Q E++ +++ +K + + + K+ E L++ + + Sbjct: 1491 LVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKL 1550 Query: 675 KTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREY 734 + D ++ + H Q + E + + L++ V S + E L+ ++ H + E Sbjct: 1551 QKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEEL 1610 Query: 735 LSLSDKICNQHNDPSKTTYISRREKFHFDNYTHE 768 L + D + + E N+ E Sbjct: 1611 HLLQGSMVQAKADLQEALRLGETEVTEKCNHIRE 1644 Score = 33.5 bits (75), Expect = 0.80 Identities = 38/180 (21%), Positives = 84/180 (46%), Gaps = 15/180 (8%) Query: 556 HQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQEST 615 H + E +L NE+ + + LK K+R + + + Q + +++ N++ LQE Sbjct: 1312 HCNVPEHHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKK 1371 Query: 616 AARQIMEREIENIQTYQSTAEENFLQ-EIKNAKSEASIYKN--SLSEIGKECEMLSKMVM 672 + +E +Q Q +++F+ +++ +E I K+ +I E E + K ++ Sbjct: 1372 SLECEVEELHRTVQKRQQ--QKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLL 1429 Query: 673 ETKTD----NQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMR 728 + +++ +++L E + S K +N++ + T+ K L ++ E D E E R Sbjct: 1430 KRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSL------LQTESDAEELERR 1483 >gi|4885583 Rho-associated, coiled-coil containing protein kinase 1 [Homo sapiens] Length = 1354 Score = 79.3 bits (194), Expect = 1e-14 Identities = 126/621 (20%), Positives = 272/621 (43%), Gaps = 73/621 (11%) Query: 160 YNNFYRFLPTAPPN---VMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEEL- 215 Y + R+L +A PN S AD + + + T+ L++ H+ Q+K+E+ Sbjct: 399 YYSNRRYLSSANPNDNRTSSNADKSLQESLQKTI--------YKLEEQLHNEMQLKDEME 450 Query: 216 QKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRI 275 QK + L ++ L + + RN + +S I ++KM N E KR Sbjct: 451 QKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKR- 509 Query: 276 SELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLK 335 +E V L E + K + +KLS+ + + N+ E + + K Sbjct: 510 RNVENEVSTLKDQLEDLKKVSQNSQLANEKLSQLQKQLEEANDLLRTE---SDTAVRLRK 566 Query: 336 FHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQ-YL 394 H+ + + ++S L+ E++++ R I EN K S T++ ++Q L Sbjct: 567 SHTEMSK-SISQLESLNRELQERNR----------ILENSK-----SQTDKDYYQLQAIL 610 Query: 395 QNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQ 454 + ++ + + +L++ +L+ ++K L + ++KVE K+ ++++ + Sbjct: 611 EAERRDRGHDSEMIGDLQARITSLQEEVKHL----KHNLEKVEGERKEAQDMLNHSEKEK 666 Query: 455 SKLSKTEEYSKECLKE-FKKIISKYNV----LQGQNKTLEEKNIQLSLEKQQMMEALDQL 509 + L Y + L++ ++ ++++ V L +++++EE S+ +M + L + Sbjct: 667 NNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAK---SVAMCEMEKKLKEE 723 Query: 510 KSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQL---LKEKSS-- 564 + K ++ + + + + + ++++ + + + KE +E + L L+++S+ Sbjct: 724 REAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNKR 783 Query: 565 --LGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIME 622 L NELK E LK E+ K E TLL+ ++ E L + + + ++ Sbjct: 784 LLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQ 843 Query: 623 REIENIQTY---------------QSTAEENF--LQEIKNAKSEASIYKNSLSEIGKECE 665 ++E Q + + EN +QE++N K E + L+E E E Sbjct: 844 DQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEK-ETLATQLDLAETKAESE 902 Query: 666 MLSKMVMETK--TDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTL 723 L++ ++E + Q K+ ++ QE ++++SRL E +L + + E + L Sbjct: 903 QLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENEEL 962 Query: 724 EFEMRHLQREY-LSLSDKICN 743 +M+ + EY L ++I N Sbjct: 963 TEKMKKAEEEYKLEKEEEISN 983 Score = 43.1 bits (100), Expect = 0.001 Identities = 70/352 (19%), Positives = 143/352 (40%), Gaps = 50/352 (14%) Query: 199 ENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIK 258 E ++D +K + +L++ + + L NEL+T + D + + M + ++N + Sbjct: 763 ERMED---EVKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQM----KQEINTLL 815 Query: 259 EEN--LDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKK 316 E L+ L + K R +E + +++L E F + + K+L + + ++ Sbjct: 816 EAKRLLEFELAQLTKQYRGNEGQ--MRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRE 873 Query: 317 NEK------NNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSI 370 N K N KE T ++ + K S + L++ E+ + ++ + I Sbjct: 874 NLKKIQELQNEKETLATQLDLAETKAESE--QLARGLLEEQYFELTQESKKAASRNRQEI 931 Query: 371 ISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKV-----MELESENLNLKSKMKPL 425 ++ S++ I+ L+ +E + KK +E E E NLK+ + Sbjct: 932 TDKDHTVSRLEEANSMLTKDIEILRRENEELTEKMKKAEEEYKLEKEEEISNLKAAFE-- 989 Query: 426 IFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQN 485 KN+ E++ ++K E K+FK K N + Sbjct: 990 ------------------KNINTERTLKTQAVNKLAEIMNR--KDFKIDRKKANTQDLRK 1029 Query: 486 KTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDM--AIVNNENNRMSIEME 535 K E + +QL L +++ E +Q+ K K +DM +V +R ++M+ Sbjct: 1030 KEKENRKLQLELNQER--EKFNQMVVKHQKELNDMQAQLVEECAHRNELQMQ 1079 >gi|109134347 NY-REN-58 antigen [Homo sapiens] Length = 701 Score = 77.4 bits (189), Expect = 5e-14 Identities = 119/570 (20%), Positives = 241/570 (42%), Gaps = 77/570 (13%) Query: 198 CENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFI 257 CE+ ++K LQ H V L NEL+ L ++ Q+K+ + Sbjct: 42 CEHHKANYQTLKAEHTRLQNEH---VKLQNELKHL-----------FNEKQTQQEKLQLL 87 Query: 258 KEENLDGNLNEDIKSKRISELEALVKKLL-------------PFRETVSKF--HVHFCRK 302 EE L G L E K +L+ L + L P RE V R Sbjct: 88 LEE-LRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRA 146 Query: 303 CKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQP 362 + E K ++ KE + +K+ S + R L++ K E++++ Sbjct: 147 VYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIAR-----LEEDKEELRNQLLNV 201 Query: 363 FLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKM 422 L K + +V + + V Q L+ E +++ + E++ N + Sbjct: 202 DLTKD---------SKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQ 252 Query: 423 KPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQ 482 + Q+ ++ +E EKQ NL E+ ++ +L + E + + + K + N L Sbjct: 253 VRQLAEMQATVRSLEA-EKQSANLRAER--LEKELQSSSEQNTFLINKLHKAEREINTLS 309 Query: 483 GQNKTLEEKN-IQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNI 541 + K L+ N ++++ K + A +L+ + +K QS++ + ++N + +E K + Sbjct: 310 SKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHK--V 367 Query: 542 LLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVK 601 LL++ ++E++ K Q KE E +++ L+++ K E E L +E +K Sbjct: 368 LLVEKDRELIRKV--QAAKE---------EGYQKLVVLQDE----KLELENRLADLEKMK 412 Query: 602 --------DEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIY 653 EK E L+ S A +I +E+++++ + + ++ + K+E S Sbjct: 413 VEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRL-KLQQQIVTIENAEKEKNENSDL 471 Query: 654 KNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQE--NIKFENSISRLTEDKILLEN 711 K +S + + L++ + NQ+LKE +++ QE N + + ++L +K L E Sbjct: 472 KQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEK 531 Query: 712 YVRSIENERDTLEFEMRHLQREYLSLSDKI 741 ++ +E E+ L + + +Y +K+ Sbjct: 532 QIQWLE-EKHKLHERITDREEKYNQAKEKL 560 Score = 64.3 bits (155), Expect = 4e-10 Identities = 99/467 (21%), Positives = 192/467 (41%), Gaps = 59/467 (12%) Query: 257 IKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKK 316 IK E+ L ED + R L + K E +++ V+ C+K K L K Sbjct: 178 IKYESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAEL--K 235 Query: 317 NEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKH------EMKDKERQPFLVKQGSI 370 EK N E + ++ + + + T+ L+ K E +KE Q + + Sbjct: 236 AEKENSEAQVENAQRIQVRQLAEM-QATVRSLEAEKQSANLRAERLEKELQSSSEQNTFL 294 Query: 371 ISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQ--KKVMELESENLNLKSKMKPLIFT 428 I++ K + + V ++++ ++++ + ELE E ++S++ L Sbjct: 295 INKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSD 354 Query: 429 TQSLIQKVETYEKQLKNLVEEKSTIQSKL--SKTEEYSKECLKEFKKIISKYNVLQGQNK 486 + L VE + K L LVE+ + K+ +K E Y K + + +K+ + N L K Sbjct: 355 NEILKAAVE-HHKVL--LVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELE-NRLADLEK 410 Query: 487 TLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQD 546 E ++ EK Q E L + E T+ ++ S+ ++ + + + Sbjct: 411 MKVEHDVWRQSEKDQYEEKLRASQMAEEITRKEL---------QSVRLKLQQQIVTIENA 461 Query: 547 EKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDE--- 603 EKE E S L ++ Q+++ L + E + L +++E +K E Sbjct: 462 EKEK---------NENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRN 512 Query: 604 --------KLNLETTLQESTAA-----RQIMEREIENIQTYQSTAEENFLQEIKNAKSEA 650 +L E TL+E ++ ER + + Y A+E + K Sbjct: 513 FRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQ-AKEKLQRAAIAQKKRK 571 Query: 651 SIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFEN 697 S+++N L + ++ E+L E +T+NQ+L +++N+ FE+ Sbjct: 572 SLHENKLKRLQEKVEVLEAKKEELETENQVL-------NRQNVPFED 611 Score = 46.2 bits (108), Expect = 1e-04 Identities = 50/198 (25%), Positives = 95/198 (47%), Gaps = 16/198 (8%) Query: 543 LIQDEKEMLE--KKTHQLLK-EKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIET 599 ++ DE+ E K +Q LK E + L NE + Q E+ L +++ T+QE L ++E Sbjct: 34 MLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQ---TQQEKLQLLLEE 90 Query: 600 VKDEKLNLETTLQESTAARQIMEREIENIQTY-QSTAEENFLQEIKNAKSEASIYKNSLS 658 ++ E + L+E + + +++E ++ Q E + +N E Y+ + Sbjct: 91 LRGELVEKTKDLEEMKL-QILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYN 149 Query: 659 EIGKECEMLSKMVMETKTDNQILKEELKKHSQEN-IKFENSISRLTEDKILLENYVRSIE 717 ++ E L K++ + KEE + E IK+E+ I+RL EDK L N + +++ Sbjct: 150 KLRYEHTFL-------KSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVD 202 Query: 718 NERDTLEFEMRHLQREYL 735 +D+ E ++ YL Sbjct: 203 LTKDSKRVEQLAREKVYL 220 >gi|109134355 NY-REN-58 antigen [Homo sapiens] Length = 701 Score = 77.4 bits (189), Expect = 5e-14 Identities = 119/570 (20%), Positives = 241/570 (42%), Gaps = 77/570 (13%) Query: 198 CENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFI 257 CE+ ++K LQ H V L NEL+ L ++ Q+K+ + Sbjct: 42 CEHHKANYQTLKAEHTRLQNEH---VKLQNELKHL-----------FNEKQTQQEKLQLL 87 Query: 258 KEENLDGNLNEDIKSKRISELEALVKKLL-------------PFRETVSKF--HVHFCRK 302 EE L G L E K +L+ L + L P RE V R Sbjct: 88 LEE-LRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRA 146 Query: 303 CKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQP 362 + E K ++ KE + +K+ S + R L++ K E++++ Sbjct: 147 VYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIAR-----LEEDKEELRNQLLNV 201 Query: 363 FLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKM 422 L K + +V + + V Q L+ E +++ + E++ N + Sbjct: 202 DLTKD---------SKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQ 252 Query: 423 KPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQ 482 + Q+ ++ +E EKQ NL E+ ++ +L + E + + + K + N L Sbjct: 253 VRQLAEMQATVRSLEA-EKQSANLRAER--LEKELQSSSEQNTFLINKLHKAEREINTLS 309 Query: 483 GQNKTLEEKN-IQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNI 541 + K L+ N ++++ K + A +L+ + +K QS++ + ++N + +E K + Sbjct: 310 SKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHK--V 367 Query: 542 LLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVK 601 LL++ ++E++ K Q KE E +++ L+++ K E E L +E +K Sbjct: 368 LLVEKDRELIRKV--QAAKE---------EGYQKLVVLQDE----KLELENRLADLEKMK 412 Query: 602 --------DEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIY 653 EK E L+ S A +I +E+++++ + + ++ + K+E S Sbjct: 413 VEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRL-KLQQQIVTIENAEKEKNENSDL 471 Query: 654 KNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQE--NIKFENSISRLTEDKILLEN 711 K +S + + L++ + NQ+LKE +++ QE N + + ++L +K L E Sbjct: 472 KQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEK 531 Query: 712 YVRSIENERDTLEFEMRHLQREYLSLSDKI 741 ++ +E E+ L + + +Y +K+ Sbjct: 532 QIQWLE-EKHKLHERITDREEKYNQAKEKL 560 Score = 64.3 bits (155), Expect = 4e-10 Identities = 99/467 (21%), Positives = 192/467 (41%), Gaps = 59/467 (12%) Query: 257 IKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKK 316 IK E+ L ED + R L + K E +++ V+ C+K K L K Sbjct: 178 IKYESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAEL--K 235 Query: 317 NEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKH------EMKDKERQPFLVKQGSI 370 EK N E + ++ + + + T+ L+ K E +KE Q + + Sbjct: 236 AEKENSEAQVENAQRIQVRQLAEM-QATVRSLEAEKQSANLRAERLEKELQSSSEQNTFL 294 Query: 371 ISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQ--KKVMELESENLNLKSKMKPLIFT 428 I++ K + + V ++++ ++++ + ELE E ++S++ L Sbjct: 295 INKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSD 354 Query: 429 TQSLIQKVETYEKQLKNLVEEKSTIQSKL--SKTEEYSKECLKEFKKIISKYNVLQGQNK 486 + L VE + K L LVE+ + K+ +K E Y K + + +K+ + N L K Sbjct: 355 NEILKAAVE-HHKVL--LVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELE-NRLADLEK 410 Query: 487 TLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQD 546 E ++ EK Q E L + E T+ ++ S+ ++ + + + Sbjct: 411 MKVEHDVWRQSEKDQYEEKLRASQMAEEITRKEL---------QSVRLKLQQQIVTIENA 461 Query: 547 EKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDE--- 603 EKE E S L ++ Q+++ L + E + L +++E +K E Sbjct: 462 EKEK---------NENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRN 512 Query: 604 --------KLNLETTLQESTAA-----RQIMEREIENIQTYQSTAEENFLQEIKNAKSEA 650 +L E TL+E ++ ER + + Y A+E + K Sbjct: 513 FRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQ-AKEKLQRAAIAQKKRK 571 Query: 651 SIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFEN 697 S+++N L + ++ E+L E +T+NQ+L +++N+ FE+ Sbjct: 572 SLHENKLKRLQEKVEVLEAKKEELETENQVL-------NRQNVPFED 611 Score = 46.2 bits (108), Expect = 1e-04 Identities = 50/198 (25%), Positives = 95/198 (47%), Gaps = 16/198 (8%) Query: 543 LIQDEKEMLE--KKTHQLLK-EKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIET 599 ++ DE+ E K +Q LK E + L NE + Q E+ L +++ T+QE L ++E Sbjct: 34 MLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQ---TQQEKLQLLLEE 90 Query: 600 VKDEKLNLETTLQESTAARQIMEREIENIQTY-QSTAEENFLQEIKNAKSEASIYKNSLS 658 ++ E + L+E + + +++E ++ Q E + +N E Y+ + Sbjct: 91 LRGELVEKTKDLEEMKL-QILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYN 149 Query: 659 EIGKECEMLSKMVMETKTDNQILKEELKKHSQEN-IKFENSISRLTEDKILLENYVRSIE 717 ++ E L K++ + KEE + E IK+E+ I+RL EDK L N + +++ Sbjct: 150 KLRYEHTFL-------KSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVD 202 Query: 718 NERDTLEFEMRHLQREYL 735 +D+ E ++ YL Sbjct: 203 LTKDSKRVEQLAREKVYL 220 >gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] Length = 3907 Score = 77.0 bits (188), Expect = 6e-14 Identities = 116/557 (20%), Positives = 238/557 (42%), Gaps = 73/557 (13%) Query: 202 DDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEEN 261 DD+ +K ++ ++++ + L E T D R + + F+ E+ Sbjct: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDL---RQQNQALEKQLEKMRKFLDEQA 2073 Query: 262 LDGNLNEDIKSKRISELEALVKKLLPFR----------ETVSKFHVHFCRKCKKLSKSEM 311 +D D+ + I +LE +K + F+ E ++ KC +L S+ Sbjct: 2074 IDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKE 2133 Query: 312 HRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSII 371 + ++ N+EI + +L+ V T ++ KH E +P L + + Sbjct: 2134 QLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKH-FGAVEAKPELSLEVQLQ 2192 Query: 372 SENE----KTSKVNSVTEQCVAKIQYLQNYLKE------SVQIQKK-----VMELESENL 416 +E + K ++ ++ EQ + L+N +E ++IQKK + ELE EN Sbjct: 2193 AERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENK 2252 Query: 417 NLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEK--STIQSKLSKTEEYSKEC--LKEFK 472 K M+ L I++ + Q ++++ K IQ K + ++ +++ L++ Sbjct: 2253 LFKDDMEKLGLA----IKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQL 2308 Query: 473 KIISKYNVLQGQNKTLEEKNIQLSL-------EKQQMMEALDQLKSKEHKTQSDMAIVNN 525 KI + V++ +N+ + + Q+ K+ E ++QL K Q ++A + Sbjct: 2309 KITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQ 2368 Query: 526 ENNR----MSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKE 581 + + +S E +++K + ++ EK LE++ +E + + N LKE+ ++ QL + Sbjct: 2369 KTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQ 2428 Query: 582 KERLAKTEQETLLQI-----------IETVKDEKLNLETTLQESTAARQIMEREIENIQT 630 + K E+E++ +I I+ + +K LE L E + +EN QT Sbjct: 2429 ELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDAL------KSLEN-QT 2481 Query: 631 YQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQ 690 Y + EEN I N ++ ++++S E K + + + Q E L+K Sbjct: 2482 YFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQK--- 2538 Query: 691 ENIKFENSISRLTEDKI 707 K N + ++ E+K+ Sbjct: 2539 ---KIVN-LQKIVEEKV 2551 Score = 76.3 bits (186), Expect = 1e-13 Identities = 157/773 (20%), Positives = 317/773 (41%), Gaps = 108/773 (13%) Query: 19 SASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQQLESFQALRMQTLQNVS 78 S K SSE +K+ + E ++Q + ++ Q+ + LR + + Sbjct: 383 SKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYG 442 Query: 79 MPTENQEENLSMEKSHHFEDSKTLHSVEEK----------LSGDSVNSLPQSVNVPSQIH 128 ++ L + E+ KT H E + ++ D + + ++N I Sbjct: 443 QQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAIN-ELNIK 501 Query: 129 SEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKI 188 +DT + + L + + E + + + L + + T+ +SK+ Sbjct: 502 LQDT---NSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKL 558 Query: 189 TVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTN---ELQTLQTDPDVHRNGKYD 245 E+L S + ++EL+ H+ EV TN +L+ L+ + + + + Sbjct: 559 NEAHKSLSTVEDLKAEIVSASESRKELELKHEAEV--TNYKIKLEMLEKEKNAVLDRMAE 616 Query: 246 MSPIHQDKMN----FIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCR 301 +++ F EE L L ED++ + +E L L +H+ + Sbjct: 617 SQEAELERLRTQLLFSHEEELS-KLKEDLEIEHRINIEKLKDNL----------GIHYKQ 665 Query: 302 KCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQ 361 + L ++EM + + + K+ IT +N L+ S++ S ++ EM + + Sbjct: 666 QIDGL-QNEMSQKIETMQFEKDNLITKQNQLILEI-SKLKDLQQSLVNSKSEEMTLQINE 723 Query: 362 PFLVKQGSIISENEKTS-KVNSVTEQCVAKIQYLQNYLKESVQ-IQKKVMELESENLNLK 419 L K+ I+ + EK + ++ K + L+ +KE +Q+K +LE+EN LK Sbjct: 724 --LQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILK 781 Query: 420 SKMKPL-----IFTTQSLIQKV---ETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEF 471 + K L I T S +++ ++ + + K+ V EK I+ + + E+ ++C++ Sbjct: 782 DEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKE-IEILIEENEDLKQQCIQLN 840 Query: 472 KKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQ----SDMAIVNNEN 527 ++I + N K E +L E +++ D L+ ++K + S + +N E Sbjct: 841 EEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL 900 Query: 528 NRMSIEMEAMKTNILLIQDEK----------EMLEKKTHQLL-------KEK-------S 563 + I +K + ++K E++EK T +L+ +EK S Sbjct: 901 HLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS 960 Query: 564 SLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMER 623 L +LK+ EI L E+ + K E+ E V LE + + A Sbjct: 961 DLSEQLKQKHGEISFLNEEVKSLKQEK-------EQVSLRCRELEIIINHNRA------- 1006 Query: 624 EIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKT--DNQIL 681 EN+Q+ T + L + S + + S+S++ K SK+++E K +N + Sbjct: 1007 --ENVQSC-DTQVSSLLDGVVTMTSRGA--EGSVSKVNKSFGEESKIMVEDKVSFENMTV 1061 Query: 682 KEELKKHSQENIKFENSISRLTEDKILLENYVRSIE-NERDTLEFEMRHLQRE 733 EE K QE + ++ S + E+ +R+ + +E D L+ E+ L+ E Sbjct: 1062 GEESK---QEQLILDHLPS------VTKESSLRATQPSENDKLQKELNVLKSE 1105 Score = 65.9 bits (159), Expect = 1e-10 Identities = 149/833 (17%), Positives = 334/833 (40%), Gaps = 134/833 (16%) Query: 12 EVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQQLESFQALRM 71 E +S L A K L++ E +K S +E + E +++ ++ + + +LE + + Sbjct: 553 EQESKLNEAHKSLSTVEDLKAEIVSASE----SRKELELKHEAEVTNYKIKLEMLEKEKN 608 Query: 72 QTLQNVSMPTENQEENLSMEK--SHHFEDSKTLHSVE-------EKLSGDSVNSLPQSVN 122 L ++ E + E L + SH E SK +E EKL + Q ++ Sbjct: 609 AVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQID 668 Query: 123 VPSQIHSEDTLTLRTSTDNL---SSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQAD 179 S+ T++ DNL + +I+ S+ D+ ++ N T N + + Sbjct: 669 GLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEI 728 Query: 180 TVILDKSK-------------ITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALT 226 ++ + K + L+ E +D+ Q++ E L Sbjct: 729 EILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAE-------NSILK 781 Query: 227 NELQTLQTDPDVHRNGKYDMSPIHQDK----MNFIKEENLDG----------NLNEDIKS 272 +E +TL+ +H +P+ Q++ ++ IK ++ D NED+K Sbjct: 782 DEKKTLEDMLKIH-------TPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQ 834 Query: 273 KRISELEALVKKLLPFRETVSKFHVHFCRKCKKLS--------------KSEMHRGKKNE 318 + I E + K+ F F V++ ++ + K E+ K + Sbjct: 835 QCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLK 894 Query: 319 KNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEK-- 376 N+E+ + N T +K S V +F+ +T + E+ + + +++ EK Sbjct: 895 ALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLE 954 Query: 377 -TSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQK 435 + +++ ++EQ K + ++L E V K ++ E E ++L+ + +I + + Sbjct: 955 LSQRLSDLSEQLKQKHGEI-SFLNEEV----KSLKQEKEQVSLRCRELEIIIN-HNRAEN 1008 Query: 436 VETYEKQLKNLVEEKSTIQSKLSK--TEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNI 493 V++ + Q+ +L++ T+ S+ ++ + +K +E K ++ + E K Sbjct: 1009 VQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQE 1068 Query: 494 QLSLEKQQMMEALDQLK----SKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLI----- 544 QL L+ + L+ S+ K Q ++ ++ +E N + ++MEA + + L+ Sbjct: 1069 QLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHV 1128 Query: 545 ---------QDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKE------------ 583 + +K + K + ++ + K QLE+ +K +E Sbjct: 1129 DQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLI 1188 Query: 584 -RLAKTEQE-------TLLQIIETVKDEKLNLETTLQE-STAARQIMEREIENIQTYQST 634 +L K E TL ++ L E ++ + I E E +Q Y+ Sbjct: 1189 GKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYE 1248 Query: 635 AEE------NFLQEIKNAKSEASIYKNSLSEI------GKECEMLSKMVMETKTDNQILK 682 ++ L ++ ++ + + LS+I G + E + + + +T+ + Sbjct: 1249 VQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIH 1308 Query: 683 EELKKHSQENIKFENSISRLTE-DKILLENYVRSIENERDTLEFEMRHLQREY 734 ++ ++ ++ +S L + +K LE V+ +E+ +L+ +++ ++ Y Sbjct: 1309 SQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361 Score = 62.8 bits (151), Expect = 1e-09 Identities = 108/562 (19%), Positives = 240/562 (42%), Gaps = 98/562 (17%) Query: 258 KEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKN 317 +++ ++ + E+I+ K + +E L K++ + + K L + + +KN Sbjct: 312 QDKKVENSNKEEIQEKE-TIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKN 370 Query: 318 EK-NNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEK 376 ++ N ++ +T + + + + + + K KD + + +V++ E E Sbjct: 371 QEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQR----MEQET 426 Query: 377 TSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLN-LKSKMKPLIFTTQSLIQK 435 K+ EQ A++ + Y ++ VQ++++++ + +K++ K + Sbjct: 427 QRKL----EQLRAELDEM--YGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSN 480 Query: 436 VETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQL 495 + E Q+K + + + KL T ++ +E I+ + LQ Q + L E +L Sbjct: 481 ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVE---EL 537 Query: 496 SLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKK- 554 S ++Q+ A + +E K NE ++ +E +K I+ + ++ LE K Sbjct: 538 SFSREQIQRARQTIAEQESKL--------NEAHKSLSTVEDLKAEIVSASESRKELELKH 589 Query: 555 ----------THQLLKEKSSLGNELKESQ-LEIIQLK------EKERLAKTE-------- 589 L KEK+++ + + ESQ E+ +L+ +E L+K + Sbjct: 590 EAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHR 649 Query: 590 ---------------------QETLLQIIETVKDEKLNLETTLQE---STAARQIMEREI 625 Q + Q IET++ EK NL T + + + +++ + Sbjct: 650 INIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSL 709 Query: 626 ENIQTYQSTAEENFLQE----IKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTD---- 677 N ++ + T + N LQ+ ++ + E + + E+ + E+L K + E + D Sbjct: 710 VNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEK 769 Query: 678 -------NQILKEELKKHSQENIKFENSISRLTEDKILLENYVRS------IENERDTLE 724 N ILK+E KK ++ +K +S+ E++++ + ++S E E + L Sbjct: 770 FAQLEAENSILKDE-KKTLEDMLKIHTPVSQ--EERLIFLDSIKSKSKDSVWEKEIEILI 826 Query: 725 FEMRHLQREYLSLSDKICNQHN 746 E L+++ + L+++I Q N Sbjct: 827 EENEDLKQQCIQLNEEIEKQRN 848 Score = 60.5 bits (145), Expect = 6e-09 Identities = 158/805 (19%), Positives = 315/805 (39%), Gaps = 141/805 (17%) Query: 4 EKQHRE--EDEVDSVLLSASKI------LNSSEGVKESGCSDTEYGCIAESENQIQPQSA 55 EKQ++E E+EV V++S S L+ G KE+ S + + + E + Sbjct: 1433 EKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMK 1492 Query: 56 LKVLQQQLESFQALRMQTLQNVSMPTENQEEN-----LSMEKSHHFEDSK--TLHSVEEK 108 L Q ++F+ + ++ + ++ E+ LS H +SK L EE Sbjct: 1493 LSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEM 1552 Query: 109 LSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLP 168 S D + QS IH E +++ ++ L N ++++ Y + Sbjct: 1553 FSKDKTFIVRQS------IHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATE 1606 Query: 169 TAPPNVMSQADTVILDKS-------KITVPFLKHGFCENLDDICHSIKQMKEEL----QK 217 M Q + D+ ++ + +N + + + + EEL Q Sbjct: 1607 LLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQL 1666 Query: 218 SHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISE 277 S G L EL+ T +NG + + + KE+ LD ED+ + +S Sbjct: 1667 SLAGREKLCCELRNSSTQT---QNGNENQGEVEEQTF---KEKELDRK-PEDVPPEILSN 1719 Query: 278 ---------------LEALVKKLLPFRETVSKFHVHFCRKCKK-------LSKSEMHRGK 315 L +VK ET+ + + + K + +SE Sbjct: 1720 ERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASV 1779 Query: 316 KNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQG----SII 371 K+ + + +T ++I S +PR ++ + E + ++ LV+ G I Sbjct: 1780 KSCVHEEHTRVTDESIPSYS-GSDMPRNDINMWSKVTEEGTELSQR--LVRSGFAGTEID 1836 Query: 372 SENEK-----TSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLI 426 ENE+ +S++ + E+ + I + L+ + Q ++M E+ K + Sbjct: 1837 PENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMR---ESFRQKQE----- 1888 Query: 427 FTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNK 486 T+SL +++L+ + E+S + +L+ L + + +I Y K Sbjct: 1889 -ATESL-----KCQEELRERLHEESRAREQLAVE-------LSKAEGVIDGY----ADEK 1931 Query: 487 TLEEKNIQLSLEKQQMMEALDQ----LKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNI- 541 TL E+ IQ EK +++ L+Q ++ + +++ + E +S + EAMK Sbjct: 1932 TLFERQIQ---EKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAG 1988 Query: 542 -----LLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQI 596 LL + EK M EK Q EK + + LEI ++ R + EQE Sbjct: 1989 PVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK---- 2044 Query: 597 IETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNS 656 T L + Q +E+++E ++ + ++ + + E +++ Sbjct: 2045 -----------NTELMDLRQQNQALEKQLEKMRKFLD-------EQAIDREHERDVFQQE 2086 Query: 657 LSEIGKECEMLSKM--VMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVR 714 + ++ ++ +++ + + E +T E+L H +E + S L K L+ ++ Sbjct: 2087 IQKLEQQLKVVPRFQPISEHQTRE---VEQLANHLKEK---TDKCSELLLSKEQLQRDIQ 2140 Query: 715 SIENERDTLEFEMRHLQREYLSLSD 739 E + LEF +R L++ L +D Sbjct: 2141 ERNEEIEKLEFRVRELEQALLVSAD 2165 Score = 55.8 bits (133), Expect = 1e-07 Identities = 77/391 (19%), Positives = 159/391 (40%), Gaps = 68/391 (17%) Query: 412 ESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEF 471 E E LN + + + + T+ L Q+++ +E +K + + + L + E ++EF Sbjct: 170 EIEELNRELEEMRVTYGTEGL-QQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREF 228 Query: 472 KKIISKYNVLQGQ-----------NKTLEEKNIQLSLEKQQMMEALDQLKSKEH------ 514 ++ + LQ Q N T L KQQ++ QL+ ++H Sbjct: 229 LELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQ 288 Query: 515 KTQSDMAI-------------------VNNENNRMSIEMEAM--KTNILLIQDEKEMLEK 553 K + D + V N N E E + + N +I++EK+ LE Sbjct: 289 KKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLEL 348 Query: 554 KTH---------QLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEK 604 K +L ++ E+K +LE+ K+KER + E + L+ +E + +K Sbjct: 349 KDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEEL--QK 406 Query: 605 LNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSE------ASIYKNSLS 658 N + + E+ +++ + ++ ++ +E + Q+I K E A + + Sbjct: 407 RNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTR 466 Query: 659 EIGKECEMLSKMVMETKTDNQI---------LKEELKKHSQENIKFENSISRLTEDKILL 709 G+ L T ++QI L +L+ + + K + + + E+K L Sbjct: 467 HKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCAL 526 Query: 710 ENYVRSIENERDTLEFEMRHLQREYLSLSDK 740 + R +E+ + L F +QR +++++ Sbjct: 527 Q---RQLEDLVEELSFSREQIQRARQTIAEQ 554 Score = 55.5 bits (132), Expect = 2e-07 Identities = 137/722 (18%), Positives = 297/722 (41%), Gaps = 55/722 (7%) Query: 30 VKESGCS-DTEYGCIAESENQIQPQSALKVLQ-QQLESFQALRMQTLQNVSMPTENQEEN 87 VK +G + + C +E +I Q K+ + Q+L + + L M++ T +E Sbjct: 2799 VKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHY 2858 Query: 88 LSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNII 147 ++++ E+ TL +V + L +S+P+ + S + + S + I Sbjct: 2859 VAVQLLK--EECGTLKAVIQCLRSKEGSSIPELAH--SDAYQTREICSSDSGSDWGQGIY 2914 Query: 148 IHPSENSDILKNYNNFYRFLPTAP-PNVMSQADTVILDKSKITVPFLKHGFCENLDDICH 206 + S+ DI T P + + ++ + + + + D H Sbjct: 2915 LTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGED---H 2971 Query: 207 SIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGK-YDMSPIHQDKMNFIKEENLDGN 265 SI+Q+ E + + + L+ L T + R + YD S H+ ++ E L Sbjct: 2972 SIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLA-- 3029 Query: 266 LNEDIKSKRI-------SELEAL-----VKKLLPFRETVSKFHVHFCRKCKKLSKSEMHR 313 L + +R +EL AL V L + + + V + + L K++ R Sbjct: 3030 LQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKAD-RR 3088 Query: 314 GKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDK--ERQPFLVKQGSII 371 +E + G+ IT LK + + L+ + + + E Q L Sbjct: 3089 SLLSEIQALHAQMNGRKIT-LKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRA 3147 Query: 372 SE-NEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKK-VMELESENLNLKSKMKPLIFTT 429 +E E+ S V + +++ + L+ +++ Q K + ELE+ L +K K + Sbjct: 3148 TELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLN 3207 Query: 430 QSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLE 489 +L + + + L +EK+ KL ++EE KE L++ K L+ Q + Sbjct: 3208 DTLASEQKKSRELQWALEKEKA----KLGRSEERDKEELEDLKFS------LESQKQRNL 3257 Query: 490 EKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKE 549 + N+ L +KQ + E+ +++S+ + ++ N + + +E+ K I + + Sbjct: 3258 QLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLD 3317 Query: 550 MLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLET 609 E++ H L+ G E + LKE ++ + + +++++ + KL+ Sbjct: 3318 R-ERELHAQLQSSDGTGQSRPPLPSEDL-LKELQKQLEEKHSRIVELLNETEKYKLDSLQ 3375 Query: 610 TLQESTAARQIMEREIENIQTYQSTAEENFLQ---EIKNAKSEASIYKNSLSEIGKECEM 666 T Q+ RQ+ + ++ Q + ++ + ++++ + + + + ++ E + Sbjct: 3376 TRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQR 3435 Query: 667 LSKMVMETKTDNQILKEELKKHSQ----ENIKFENSISRLTEDKILLENYVRSIENERDT 722 L ++ E + Q L+ E K+ S+ +N+ E + LT D+ N+V + E +T Sbjct: 3436 LQGIMQEFQ--KQELEREEKRESRRILYQNLN-EPTTWSLTSDR--TRNWVLQQKIEGET 3490 Query: 723 LE 724 E Sbjct: 3491 KE 3492 Score = 53.5 bits (127), Expect = 7e-07 Identities = 146/805 (18%), Positives = 302/805 (37%), Gaps = 157/805 (19%) Query: 4 EKQHREEDEVDSVLLSASKILNSSEGVKESGCSDT------EYGCIAESENQIQPQSALK 57 EK E++ LL ++ E K G + E AE + + + + Sbjct: 2147 EKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEIT 2206 Query: 58 VLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSL 117 L++QLE F+ + L+N + + L ++K + L E KL D + L Sbjct: 2207 NLEEQLEQFR----EELENKNEEVQQLHMQLEIQKKESTTRLQELEQ-ENKLFKDDMEKL 2261 Query: 118 PQSVNVPSQIHSEDTLTL-----------RTSTDNLSSNII-----IHPSENSDILKNYN 161 ++ + ++D L D L+ + + + ++ +++ N Sbjct: 2262 GLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKN 2321 Query: 162 NFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEEL----QK 217 R L T +MS + V ++ E ++ + I+++++EL QK Sbjct: 2322 ELIRDLETQIECLMSDQECVKRNRE------------EEIEQLNEVIEKLQQELANIGQK 2369 Query: 218 SHDGEVALTNELQTLQTDPDVHRNGKYDMSP---IHQDKMNFIKEENLDGNLNEDIKSKR 274 + +L+ E +L+ DV K + ++M F+K + N + Sbjct: 2370 TSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNF-------K 2422 Query: 275 ISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDL 334 +++L + L RE+V K + IP N+ Sbjct: 2423 MNQLTQELFSLKRERESVEKI--------------------------QSIPENSVNVAID 2456 Query: 335 KFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYL 394 P + T+ +K E Q + EN K S +N T Sbjct: 2457 HLSKDKPELEVVL---TEDALKSLENQTYFKS----FEENGKGSIINLETR--------- 2500 Query: 395 QNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQ 454 L+ + K +EL +K + F T+ L +K+ +K ++ V Q Sbjct: 2501 --LLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQ 2558 Query: 455 SKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEH 514 +L +EY+K C N+T+ + + +++ L+QL +E Sbjct: 2559 IQLEAVQEYAKFC---------------QDNQTISSEPERTNIQN------LNQL--RED 2595 Query: 515 KTQSDMAIVNNENNRMSIEMEAMKTNILLIQD-----EKEMLEKKTHQLLKEKSSLGNEL 569 + SD++ + + + ++ M T+++L ++ EK +LEK+ L +K GNE Sbjct: 2596 ELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEK 2655 Query: 570 KESQLEIIQLKEKERLAKT--------EQETLLQIIETVKDEKLNLETTLQESTAARQIM 621 K+ + E + + + KT E+ +E ++ E + + L + + Sbjct: 2656 KQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKL 2715 Query: 622 EREIENIQTYQSTAEENFLQ---EIKNAKSEASIY----KNSLSEIGKECEM------LS 668 + E+ +T ++ +++ Q + AK + SI + + E K C LS Sbjct: 2716 QEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLS 2775 Query: 669 KMV-------METKTDNQILKEELKKHS-QENIKFENSISRLTEDKILLENYVRSIENER 720 K + ++ + NQ + +K Q N++ E S +TE ++ + IE + Sbjct: 2776 KSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTE---IISQFTEKIEKMQ 2832 Query: 721 DTLEFEMRHLQREYLSLSDKICNQH 745 + E+ ++ ++S ++ + +H Sbjct: 2833 ELHAAEILDMESRHISETETLKREH 2857 Score = 46.2 bits (108), Expect = 1e-04 Identities = 67/317 (21%), Positives = 146/317 (46%), Gaps = 44/317 (13%) Query: 430 QSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLE 489 +SL+ +++ Q+ K T++ + ++E+ S+E L+ YN+ Q Q++ LE Sbjct: 3088 RSLLSEIQALHAQMNG---RKITLKRE-QESEKPSQELLE--------YNIQQKQSQMLE 3135 Query: 490 EKNIQLSLEKQQMMEALDQL----------KSKEHKTQSDMAIVNNENNRMSIEMEAMKT 539 + ++LS K + E +QL KS+ +T+ ++ ++ E+EA + Sbjct: 3136 MQ-VELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRL 3194 Query: 540 NILLIQDEKEMLEKKTHQLLKEKSSLGNELKES-QLEIIQLKEKERLAKTEQETLLQIIE 598 + DE +L +L +E K+S +L+ KEK +L ++E+ E Sbjct: 3195 EVKDKTDEVHLL----------NDTLASEQKKSRELQWALEKEKAKLGRSEERDK----E 3240 Query: 599 TVKDEKLNLETTLQESTAARQIMEREIENI-QTYQSTAEENFLQEIKNAKSEASIYKNSL 657 ++D K +LE+ Q + ++E++ + + ++ Q + L + + ++ + + + Sbjct: 3241 ELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQV 3300 Query: 658 ---SEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVR 714 SE + EM S + E + Q+ + S+ + E+ + L K L E + R Sbjct: 3301 LLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKEL--QKQLEEKHSR 3358 Query: 715 SIENERDTLEFEMRHLQ 731 +E +T ++++ LQ Sbjct: 3359 IVELLNETEKYKLDSLQ 3375 >gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] Length = 1088 Score = 76.3 bits (186), Expect = 1e-13 Identities = 161/819 (19%), Positives = 322/819 (39%), Gaps = 152/819 (18%) Query: 43 IAESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMPT------ENQEENLSMEKSHHF 96 + + ENQ Q ++ LQ +L + L Q+ S T E EEN + H Sbjct: 217 VVQEENQ-HMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHE 275 Query: 97 EDSKTLHSVEEKLSG---------DSVNSLPQSVNVPSQIHSEDTLTLRTSTDN------ 141 +K L + + L ++N+ +S+ ++ L+ + + ++ Sbjct: 276 RQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRR 335 Query: 142 -LSSNIIIHPSENSDILKNYNN------FYRFLPTAPPNVMSQADTVILDKSKITVPFLK 194 + + +H E+ K N +R AP + ++A +++ + ++ Sbjct: 336 LAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSME 395 Query: 195 HGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRN-GKYDMSPIHQDK 253 G ++ ++EE+Q T E + +V+R+ K+ + I Q K Sbjct: 396 RG-----------LRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVK 444 Query: 254 MNFIKEEN--------LDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKK 305 +++ L+ N+ SK+ +E L + L + + + Sbjct: 445 QELSRKDTELLALQTKLETLTNQFSDSKQ--HIEVLKESLTAKEQRAAILQTEVDALRLR 502 Query: 306 LSKSEMHRGKKNEKNN---KEIPITGKNITDLKFHSRVPRYTLSFL----DQTKHEMKDK 358 L + E KK ++ +E I DLK V ++ L + + +++DK Sbjct: 503 LEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDK 562 Query: 359 ERQPFLVKQG--SIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENL 416 E+Q +K+ S+ ++ T + E+ +A+ + LKE Q+ E E + Sbjct: 563 EKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKE----QRDRDEREKQ-- 616 Query: 417 NLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIIS 476 ++++ Y+K LK+L E+ S +Q LS+ E + + + S Sbjct: 617 -----------------EEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLAS 659 Query: 477 KYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEA 536 + KTLE I L +K++ ++ QLK K H+ A+ + MS ++ Sbjct: 660 SGLKKDSRLKTLE---IALEQKKEECLKMESQLK-KAHEA----ALEARASPEMSDRIQH 711 Query: 537 MKTNILLIQDEKEMLEKKTHQLL--------------KEKSSLGNELKESQLEIIQLKEK 582 ++ I +DE + + +LL K+ + L ++K+ ++ LK K Sbjct: 712 LEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHK 771 Query: 583 ERLAKTEQETLL---------------QIIETV--KDEKL-NLETTLQES---TAARQIM 621 E++ K + +L Q+ +++ KD+++ LE L+ES TA R+++ Sbjct: 772 EQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMV 831 Query: 622 EREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQIL 681 + E+ +T E L ++ K E K LS + + E +T L Sbjct: 832 LAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSS-------TQQSLAEKETHLTNL 884 Query: 682 KEELKKHSQENIKFEN-----SISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLS 736 + E +KH +E ++ + +IS + LLE + + + + E+ L+RE Sbjct: 885 RAERRKHLEEVLEMKQEALLAAISEKDANIALLE-----LSSSKKKTQEEVAALKRE--- 936 Query: 737 LSDKICNQHNDPSKTTYISRREKFHFDNYTHEDTSSPQS 775 D++ Q ++ R K DNY + S S Sbjct: 937 -KDRLVQQLKQQTQ-----NRMKLMADNYEDDHFKSSHS 969 Score = 51.2 bits (121), Expect = 4e-06 Identities = 121/615 (19%), Positives = 245/615 (39%), Gaps = 71/615 (11%) Query: 1 MSPEKQHRE-EDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVL 59 M E+ HR E+ DS + +K L + +K+S S E G + + E +IQ + L Sbjct: 359 MLREEMHRRFENAPDS---AKTKALQTVIEMKDSKISSMERG-LRDLEEEIQMLKSNGAL 414 Query: 60 QQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQ 119 + + +M+ ++ S +N+ + E S + L + E L+ +S Sbjct: 415 STEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQH 474 Query: 120 SVNVPSQIHSED--TLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQ 177 + + +++ L+T D L + + + K + T + Sbjct: 475 IEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDL 534 Query: 178 ADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPD 237 D + + + K+ V + I+ ++E+L+ +L +++LQ D Sbjct: 535 KDMLDVKERKVNV-------------LQKKIENLQEQLRDKEKQMSSLKERVKSLQADTT 581 Query: 238 VHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHV 297 + +K I E L + D + K+ E++ K L +E VS Sbjct: 582 NTDTALTTLEEALAEKERTI--ERLKEQRDRDEREKQ-EEIDNYKKDLKDLKEKVSLLQG 638 Query: 298 HFCRK------CKKLSKSEMHRGKKNEKNNK--EIPITGKNITDLKFHSRVPRYTLSFLD 349 K K+ + S G K + K EI + K LK S++ + + L+ Sbjct: 639 DLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALE 698 Query: 350 -QTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKV 408 + EM D+ + + I +++SK + ++ + ++ ++N E KK+ Sbjct: 699 ARASPEMSDRIQH----LEREITRYKDESSKAQAEVDRLLEILKEVEN---EKNDKDKKI 751 Query: 409 MELESENLNLKSKMKPLIFTTQ----SLIQKVETYEKQLKNLVEEKSTIQSKLSKTE--- 461 ELE + + K+ L Q Q +E ++ NL + +Q L K + Sbjct: 752 AELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRI 811 Query: 462 EYSKECLKEFKKIISKYNVLQGQN---KTLEEKNIQ-LSLEKQQMMEALDQLKSKEHKTQ 517 E +E L+E +I ++ ++ Q +T EK ++ L + +++ + L+ +K+K TQ Sbjct: 812 EELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQ 871 Query: 518 SDMA-----IVNNENNR-------MSIEMEAM-------KTNILLIQ--DEKEMLEKKTH 556 +A + N R + ++ EA+ NI L++ K+ +++ Sbjct: 872 QSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVA 931 Query: 557 QLLKEKSSLGNELKE 571 L +EK L +LK+ Sbjct: 932 ALKREKDRLVQQLKQ 946 >gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] Length = 3899 Score = 76.3 bits (186), Expect = 1e-13 Identities = 157/773 (20%), Positives = 317/773 (41%), Gaps = 108/773 (13%) Query: 19 SASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQQLESFQALRMQTLQNVS 78 S K SSE +K+ + E ++Q + ++ Q+ + LR + + Sbjct: 383 SKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYG 442 Query: 79 MPTENQEENLSMEKSHHFEDSKTLHSVEEK----------LSGDSVNSLPQSVNVPSQIH 128 ++ L + E+ KT H E + ++ D + + ++N I Sbjct: 443 QQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAIN-ELNIK 501 Query: 129 SEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKI 188 +DT + + L + + E + + + L + + T+ +SK+ Sbjct: 502 LQDT---NSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKL 558 Query: 189 TVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTN---ELQTLQTDPDVHRNGKYD 245 E+L S + ++EL+ H+ EV TN +L+ L+ + + + + Sbjct: 559 NEAHKSLSTVEDLKAEIVSASESRKELELKHEAEV--TNYKIKLEMLEKEKNAVLDRMAE 616 Query: 246 MSPIHQDKMN----FIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCR 301 +++ F EE L L ED++ + +E L L +H+ + Sbjct: 617 SQEAELERLRTQLLFSHEEELS-KLKEDLEIEHRINIEKLKDNL----------GIHYKQ 665 Query: 302 KCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQ 361 + L ++EM + + + K+ IT +N L+ S++ S ++ EM + + Sbjct: 666 QIDGL-QNEMSQKIETMQFEKDNLITKQNQLILEI-SKLKDLQQSLVNSKSEEMTLQINE 723 Query: 362 PFLVKQGSIISENEKTS-KVNSVTEQCVAKIQYLQNYLKESVQ-IQKKVMELESENLNLK 419 L K+ I+ + EK + ++ K + L+ +KE +Q+K +LE+EN LK Sbjct: 724 --LQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILK 781 Query: 420 SKMKPL-----IFTTQSLIQKV---ETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEF 471 + K L I T S +++ ++ + + K+ V EK I+ + + E+ ++C++ Sbjct: 782 DEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKE-IEILIEENEDLKQQCIQLN 840 Query: 472 KKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQ----SDMAIVNNEN 527 ++I + N K E +L E +++ D L+ ++K + S + +N E Sbjct: 841 EEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL 900 Query: 528 NRMSIEMEAMKTNILLIQDEK----------EMLEKKTHQLL-------KEK-------S 563 + I +K + ++K E++EK T +L+ +EK S Sbjct: 901 HLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS 960 Query: 564 SLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMER 623 L +LK+ EI L E+ + K E+ E V LE + + A Sbjct: 961 DLSEQLKQKHGEISFLNEEVKSLKQEK-------EQVSLRCRELEIIINHNRA------- 1006 Query: 624 EIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKT--DNQIL 681 EN+Q+ T + L + S + + S+S++ K SK+++E K +N + Sbjct: 1007 --ENVQSC-DTQVSSLLDGVVTMTSRGA--EGSVSKVNKSFGEESKIMVEDKVSFENMTV 1061 Query: 682 KEELKKHSQENIKFENSISRLTEDKILLENYVRSIE-NERDTLEFEMRHLQRE 733 EE K QE + ++ S + E+ +R+ + +E D L+ E+ L+ E Sbjct: 1062 GEESK---QEQLILDHLPS------VTKESSLRATQPSENDKLQKELNVLKSE 1105 Score = 76.3 bits (186), Expect = 1e-13 Identities = 116/554 (20%), Positives = 241/554 (43%), Gaps = 75/554 (13%) Query: 202 DDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEEN 261 DD+ +K ++ ++++ + L E T D R + + F+ E+ Sbjct: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDL---RQQNQALEKQLEKMRKFLDEQA 2073 Query: 262 LDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKK----- 316 +D D+ + I +LE +K ++P + +S+ H R+ ++L+ + K Sbjct: 2074 IDREHERDVFQQEIQKLEQQLK-VVPRFQPISE---HQTREVEQLANHLKEKTDKCSELL 2129 Query: 317 --NEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISEN 374 E+ ++I + I L+F RV + L + + E +P L + + +E Sbjct: 2130 LSKEQLQRDIQERNEEIEKLEF--RVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAER 2187 Query: 375 E----KTSKVNSVTEQCVAKIQYLQNYLKE------SVQIQKK-----VMELESENLNLK 419 + K ++ ++ EQ + L+N +E ++IQKK + ELE EN K Sbjct: 2188 DAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFK 2247 Query: 420 SKMKPLIFTTQSLIQKVETYEKQLKNLVEEK--STIQSKLSKTEEYSKEC--LKEFKKII 475 M+ L I++ + Q ++++ K IQ K + ++ +++ L++ KI Sbjct: 2248 DDMEKLGLA----IKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKIT 2303 Query: 476 SKYNVLQGQNKTLEEKNIQLSL-------EKQQMMEALDQLKSKEHKTQSDMAIVNNENN 528 + V++ +N+ + + Q+ K+ E ++QL K Q ++A + + + Sbjct: 2304 TDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTS 2363 Query: 529 R----MSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKER 584 +S E +++K + ++ EK LE++ +E + + N LKE+ ++ QL ++ Sbjct: 2364 MNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELF 2423 Query: 585 LAKTEQETLLQI-----------IETVKDEKLNLETTLQESTAARQIMEREIENIQTYQS 633 K E+E++ +I I+ + +K LE L E + +EN QTY Sbjct: 2424 SLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDAL------KSLEN-QTYFK 2476 Query: 634 TAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENI 693 + EEN I N ++ ++++S E K + + + Q E L+K Sbjct: 2477 SFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQK------ 2530 Query: 694 KFENSISRLTEDKI 707 K N + ++ E+K+ Sbjct: 2531 KIVN-LQKIVEEKV 2543 Score = 65.9 bits (159), Expect = 1e-10 Identities = 149/833 (17%), Positives = 334/833 (40%), Gaps = 134/833 (16%) Query: 12 EVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQQLESFQALRM 71 E +S L A K L++ E +K S +E + E +++ ++ + + +LE + + Sbjct: 553 EQESKLNEAHKSLSTVEDLKAEIVSASE----SRKELELKHEAEVTNYKIKLEMLEKEKN 608 Query: 72 QTLQNVSMPTENQEENLSMEK--SHHFEDSKTLHSVE-------EKLSGDSVNSLPQSVN 122 L ++ E + E L + SH E SK +E EKL + Q ++ Sbjct: 609 AVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQID 668 Query: 123 VPSQIHSEDTLTLRTSTDNL---SSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQAD 179 S+ T++ DNL + +I+ S+ D+ ++ N T N + + Sbjct: 669 GLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEI 728 Query: 180 TVILDKSK-------------ITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALT 226 ++ + K + L+ E +D+ Q++ E L Sbjct: 729 EILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAE-------NSILK 781 Query: 227 NELQTLQTDPDVHRNGKYDMSPIHQDK----MNFIKEENLDG----------NLNEDIKS 272 +E +TL+ +H +P+ Q++ ++ IK ++ D NED+K Sbjct: 782 DEKKTLEDMLKIH-------TPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQ 834 Query: 273 KRISELEALVKKLLPFRETVSKFHVHFCRKCKKLS--------------KSEMHRGKKNE 318 + I E + K+ F F V++ ++ + K E+ K + Sbjct: 835 QCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLK 894 Query: 319 KNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEK-- 376 N+E+ + N T +K S V +F+ +T + E+ + + +++ EK Sbjct: 895 ALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLE 954 Query: 377 -TSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQK 435 + +++ ++EQ K + ++L E V K ++ E E ++L+ + +I + + Sbjct: 955 LSQRLSDLSEQLKQKHGEI-SFLNEEV----KSLKQEKEQVSLRCRELEIIIN-HNRAEN 1008 Query: 436 VETYEKQLKNLVEEKSTIQSKLSK--TEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNI 493 V++ + Q+ +L++ T+ S+ ++ + +K +E K ++ + E K Sbjct: 1009 VQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQE 1068 Query: 494 QLSLEKQQMMEALDQLK----SKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLI----- 544 QL L+ + L+ S+ K Q ++ ++ +E N + ++MEA + + L+ Sbjct: 1069 QLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHV 1128 Query: 545 ---------QDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKE------------ 583 + +K + K + ++ + K QLE+ +K +E Sbjct: 1129 DQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLI 1188 Query: 584 -RLAKTEQE-------TLLQIIETVKDEKLNLETTLQE-STAARQIMEREIENIQTYQST 634 +L K E TL ++ L E ++ + I E E +Q Y+ Sbjct: 1189 GKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYE 1248 Query: 635 AEE------NFLQEIKNAKSEASIYKNSLSEI------GKECEMLSKMVMETKTDNQILK 682 ++ L ++ ++ + + LS+I G + E + + + +T+ + Sbjct: 1249 VQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIH 1308 Query: 683 EELKKHSQENIKFENSISRLTE-DKILLENYVRSIENERDTLEFEMRHLQREY 734 ++ ++ ++ +S L + +K LE V+ +E+ +L+ +++ ++ Y Sbjct: 1309 SQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361 Score = 62.8 bits (151), Expect = 1e-09 Identities = 108/562 (19%), Positives = 240/562 (42%), Gaps = 98/562 (17%) Query: 258 KEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKN 317 +++ ++ + E+I+ K + +E L K++ + + K L + + +KN Sbjct: 312 QDKKVENSNKEEIQEKE-TIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKN 370 Query: 318 EK-NNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEK 376 ++ N ++ +T + + + + + + K KD + + +V++ E E Sbjct: 371 QEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQR----MEQET 426 Query: 377 TSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLN-LKSKMKPLIFTTQSLIQK 435 K+ EQ A++ + Y ++ VQ++++++ + +K++ K + Sbjct: 427 QRKL----EQLRAELDEM--YGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSN 480 Query: 436 VETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQL 495 + E Q+K + + + KL T ++ +E I+ + LQ Q + L E +L Sbjct: 481 ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVE---EL 537 Query: 496 SLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKK- 554 S ++Q+ A + +E K NE ++ +E +K I+ + ++ LE K Sbjct: 538 SFSREQIQRARQTIAEQESKL--------NEAHKSLSTVEDLKAEIVSASESRKELELKH 589 Query: 555 ----------THQLLKEKSSLGNELKESQ-LEIIQLK------EKERLAKTE-------- 589 L KEK+++ + + ESQ E+ +L+ +E L+K + Sbjct: 590 EAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHR 649 Query: 590 ---------------------QETLLQIIETVKDEKLNLETTLQE---STAARQIMEREI 625 Q + Q IET++ EK NL T + + + +++ + Sbjct: 650 INIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSL 709 Query: 626 ENIQTYQSTAEENFLQE----IKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTD---- 677 N ++ + T + N LQ+ ++ + E + + E+ + E+L K + E + D Sbjct: 710 VNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEK 769 Query: 678 -------NQILKEELKKHSQENIKFENSISRLTEDKILLENYVRS------IENERDTLE 724 N ILK+E KK ++ +K +S+ E++++ + ++S E E + L Sbjct: 770 FAQLEAENSILKDE-KKTLEDMLKIHTPVSQ--EERLIFLDSIKSKSKDSVWEKEIEILI 826 Query: 725 FEMRHLQREYLSLSDKICNQHN 746 E L+++ + L+++I Q N Sbjct: 827 EENEDLKQQCIQLNEEIEKQRN 848 Score = 59.3 bits (142), Expect = 1e-08 Identities = 157/801 (19%), Positives = 313/801 (39%), Gaps = 141/801 (17%) Query: 4 EKQHRE--EDEVDSVLLSASKI------LNSSEGVKESGCSDTEYGCIAESENQIQPQSA 55 EKQ++E E+EV V++S S L+ G KE+ S + + + E + Sbjct: 1433 EKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMK 1492 Query: 56 LKVLQQQLESFQALRMQTLQNVSMPTENQEEN-----LSMEKSHHFEDSK--TLHSVEEK 108 L Q ++F+ + ++ + ++ E+ LS H +SK L EE Sbjct: 1493 LSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEM 1552 Query: 109 LSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLP 168 S D + QS IH E +++ ++ L N ++++ Y + Sbjct: 1553 FSKDKTFIVRQS------IHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATE 1606 Query: 169 TAPPNVMSQADTVILDKS-------KITVPFLKHGFCENLDDICHSIKQMKEEL----QK 217 M Q + D+ ++ + +N + + + + EEL Q Sbjct: 1607 LLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQL 1666 Query: 218 SHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISE 277 S G L EL+ T +NG + + + KE+ LD ED+ + +S Sbjct: 1667 SLAGREKLCCELRNSSTQT---QNGNENQGEVEEQTF---KEKELDRK-PEDVPPEILSN 1719 Query: 278 ---------------LEALVKKLLPFRETVSKFHVHFCRKCKK-------LSKSEMHRGK 315 L +VK ET+ + + + K + +SE Sbjct: 1720 ERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASV 1779 Query: 316 KNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQG----SII 371 K+ + + +T ++I S +PR ++ + E + ++ LV+ G I Sbjct: 1780 KSCVHEEHTRVTDESIPSYS-GSDMPRNDINMWSKVTEEGTELSQR--LVRSGFAGTEID 1836 Query: 372 SENEK-----TSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLI 426 ENE+ +S++ + E+ + I + L+ + Q ++M E+ K + Sbjct: 1837 PENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMR---ESFRQKQE----- 1888 Query: 427 FTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNK 486 T+SL +++L+ + E+S + +L+ L + + +I Y K Sbjct: 1889 -ATESL-----KCQEELRERLHEESRAREQLAVE-------LSKAEGVIDGY----ADEK 1931 Query: 487 TLEEKNIQLSLEKQQMMEALDQ----LKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNI- 541 TL E+ IQ EK +++ L+Q ++ + +++ + E +S + EAMK Sbjct: 1932 TLFERQIQ---EKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAG 1988 Query: 542 -----LLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQI 596 LL + EK M EK Q EK + + LEI ++ R + EQE Sbjct: 1989 PVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK---- 2044 Query: 597 IETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNS 656 T L + Q +E+++E ++ + ++ + + E +++ Sbjct: 2045 -----------NTELMDLRQQNQALEKQLEKMRKFLD-------EQAIDREHERDVFQQE 2086 Query: 657 LSEIGKECEMLSKM--VMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVR 714 + ++ ++ +++ + + E +T E+L H +E + S L K L+ ++ Sbjct: 2087 IQKLEQQLKVVPRFQPISEHQTRE---VEQLANHLKEK---TDKCSELLLSKEQLQRDIQ 2140 Query: 715 SIENERDTLEFEMRHLQREYL 735 E + LEF +R L++ L Sbjct: 2141 ERNEEIEKLEFRVRELEQALL 2161 Score = 55.8 bits (133), Expect = 1e-07 Identities = 77/391 (19%), Positives = 159/391 (40%), Gaps = 68/391 (17%) Query: 412 ESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEF 471 E E LN + + + + T+ L Q+++ +E +K + + + L + E ++EF Sbjct: 170 EIEELNRELEEMRVTYGTEGL-QQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREF 228 Query: 472 KKIISKYNVLQGQ-----------NKTLEEKNIQLSLEKQQMMEALDQLKSKEH------ 514 ++ + LQ Q N T L KQQ++ QL+ ++H Sbjct: 229 LELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQ 288 Query: 515 KTQSDMAI-------------------VNNENNRMSIEMEAM--KTNILLIQDEKEMLEK 553 K + D + V N N E E + + N +I++EK+ LE Sbjct: 289 KKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLEL 348 Query: 554 KTH---------QLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEK 604 K +L ++ E+K +LE+ K+KER + E + L+ +E + +K Sbjct: 349 KDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEEL--QK 406 Query: 605 LNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSE------ASIYKNSLS 658 N + + E+ +++ + ++ ++ +E + Q+I K E A + + Sbjct: 407 RNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTR 466 Query: 659 EIGKECEMLSKMVMETKTDNQI---------LKEELKKHSQENIKFENSISRLTEDKILL 709 G+ L T ++QI L +L+ + + K + + + E+K L Sbjct: 467 HKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCAL 526 Query: 710 ENYVRSIENERDTLEFEMRHLQREYLSLSDK 740 + R +E+ + L F +QR +++++ Sbjct: 527 Q---RQLEDLVEELSFSREQIQRARQTIAEQ 554 Score = 55.5 bits (132), Expect = 2e-07 Identities = 137/722 (18%), Positives = 297/722 (41%), Gaps = 55/722 (7%) Query: 30 VKESGCS-DTEYGCIAESENQIQPQSALKVLQ-QQLESFQALRMQTLQNVSMPTENQEEN 87 VK +G + + C +E +I Q K+ + Q+L + + L M++ T +E Sbjct: 2791 VKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHY 2850 Query: 88 LSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNII 147 ++++ E+ TL +V + L +S+P+ + S + + S + I Sbjct: 2851 VAVQLLK--EECGTLKAVIQCLRSKEGSSIPELAH--SDAYQTREICSSDSGSDWGQGIY 2906 Query: 148 IHPSENSDILKNYNNFYRFLPTAP-PNVMSQADTVILDKSKITVPFLKHGFCENLDDICH 206 + S+ DI T P + + ++ + + + + D H Sbjct: 2907 LTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGED---H 2963 Query: 207 SIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGK-YDMSPIHQDKMNFIKEENLDGN 265 SI+Q+ E + + + L+ L T + R + YD S H+ ++ E L Sbjct: 2964 SIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLA-- 3021 Query: 266 LNEDIKSKRI-------SELEAL-----VKKLLPFRETVSKFHVHFCRKCKKLSKSEMHR 313 L + +R +EL AL V L + + + V + + L K++ R Sbjct: 3022 LQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKAD-RR 3080 Query: 314 GKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDK--ERQPFLVKQGSII 371 +E + G+ IT LK + + L+ + + + E Q L Sbjct: 3081 SLLSEIQALHAQMNGRKIT-LKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRA 3139 Query: 372 SE-NEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKK-VMELESENLNLKSKMKPLIFTT 429 +E E+ S V + +++ + L+ +++ Q K + ELE+ L +K K + Sbjct: 3140 TELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLN 3199 Query: 430 QSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLE 489 +L + + + L +EK+ KL ++EE KE L++ K L+ Q + Sbjct: 3200 DTLASEQKKSRELQWALEKEKA----KLGRSEERDKEELEDLKFS------LESQKQRNL 3249 Query: 490 EKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKE 549 + N+ L +KQ + E+ +++S+ + ++ N + + +E+ K I + + Sbjct: 3250 QLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLD 3309 Query: 550 MLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLET 609 E++ H L+ G E + LKE ++ + + +++++ + KL+ Sbjct: 3310 R-ERELHAQLQSSDGTGQSRPPLPSEDL-LKELQKQLEEKHSRIVELLNETEKYKLDSLQ 3367 Query: 610 TLQESTAARQIMEREIENIQTYQSTAEENFLQ---EIKNAKSEASIYKNSLSEIGKECEM 666 T Q+ RQ+ + ++ Q + ++ + ++++ + + + + ++ E + Sbjct: 3368 TRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQR 3427 Query: 667 LSKMVMETKTDNQILKEELKKHSQ----ENIKFENSISRLTEDKILLENYVRSIENERDT 722 L ++ E + Q L+ E K+ S+ +N+ E + LT D+ N+V + E +T Sbjct: 3428 LQGIMQEFQ--KQELEREEKRESRRILYQNLN-EPTTWSLTSDR--TRNWVLQQKIEGET 3482 Query: 723 LE 724 E Sbjct: 3483 KE 3484 Score = 52.0 bits (123), Expect = 2e-06 Identities = 137/759 (18%), Positives = 288/759 (37%), Gaps = 151/759 (19%) Query: 44 AESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLH 103 AE + + + + L++QLE F+ + L+N + + L ++K + L Sbjct: 2185 AERDAIDRKEKEITNLEEQLEQFR----EELENKNEEVQQLHMQLEIQKKESTTRLQELE 2240 Query: 104 SVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTL-----------RTSTDNLSSNII----- 147 E KL D + L ++ + ++D L D L+ + Sbjct: 2241 Q-ENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQ 2299 Query: 148 IHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHS 207 + + ++ +++ N R L T +MS + V ++ E ++ + Sbjct: 2300 LKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNRE------------EEIEQLNEV 2347 Query: 208 IKQMKEEL----QKSHDGEVALTNELQTLQTDPDVHRNGKYDMSP---IHQDKMNFIKEE 260 I+++++EL QK+ +L+ E +L+ DV K + ++M F+K Sbjct: 2348 IEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNV 2407 Query: 261 NLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKN 320 + N ++++L + L RE+V K Sbjct: 2408 LKETNF-------KMNQLTQELFSLKRERESVEKI------------------------- 2435 Query: 321 NKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKV 380 + IP N+ P + T+ +K E Q + EN K S + Sbjct: 2436 -QSIPENSVNVAIDHLSKDKPELEVVL---TEDALKSLENQTYFKS----FEENGKGSII 2487 Query: 381 NSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYE 440 N T L+ + K +EL +K + F T+ L +K+ + Sbjct: 2488 NLETR-----------LLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQ 2536 Query: 441 KQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQ 500 K ++ V Q +L +EY+K C N+T+ + + +++ Sbjct: 2537 KIVEEKVAAALVSQIQLEAVQEYAKFC---------------QDNQTISSEPERTNIQN- 2580 Query: 501 QMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQD-----EKEMLEKKT 555 L+QL +E + SD++ + + + ++ M T+++L ++ EK +LEK+ Sbjct: 2581 -----LNQL--REDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEK 2633 Query: 556 HQLLKEKSSLGNELKESQLEIIQLKEKERLAKT--------EQETLLQIIETVKDEKLNL 607 L +K GNE K+ + E + + + KT E+ +E ++ E + Sbjct: 2634 KLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVAT 2693 Query: 608 ETTLQESTAARQIMEREIENIQTYQSTAEENFLQ---EIKNAKSEASIY----KNSLSEI 660 + L + ++ E+ +T ++ +++ Q + AK + SI + + E Sbjct: 2694 KAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQES 2753 Query: 661 GKECEM------LSKMV-------METKTDNQILKEELKKHS-QENIKFENSISRLTEDK 706 K C LSK + ++ + NQ + +K Q N++ E S +TE Sbjct: 2754 KKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTE-- 2811 Query: 707 ILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQH 745 ++ + IE ++ E+ ++ ++S ++ + +H Sbjct: 2812 -IISQFTEKIEKMQELHAAEILDMESRHISETETLKREH 2849 Score = 46.2 bits (108), Expect = 1e-04 Identities = 67/317 (21%), Positives = 146/317 (46%), Gaps = 44/317 (13%) Query: 430 QSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLE 489 +SL+ +++ Q+ K T++ + ++E+ S+E L+ YN+ Q Q++ LE Sbjct: 3080 RSLLSEIQALHAQMNG---RKITLKRE-QESEKPSQELLE--------YNIQQKQSQMLE 3127 Query: 490 EKNIQLSLEKQQMMEALDQL----------KSKEHKTQSDMAIVNNENNRMSIEMEAMKT 539 + ++LS K + E +QL KS+ +T+ ++ ++ E+EA + Sbjct: 3128 MQ-VELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRL 3186 Query: 540 NILLIQDEKEMLEKKTHQLLKEKSSLGNELKES-QLEIIQLKEKERLAKTEQETLLQIIE 598 + DE +L +L +E K+S +L+ KEK +L ++E+ E Sbjct: 3187 EVKDKTDEVHLL----------NDTLASEQKKSRELQWALEKEKAKLGRSEERDK----E 3232 Query: 599 TVKDEKLNLETTLQESTAARQIMEREIENI-QTYQSTAEENFLQEIKNAKSEASIYKNSL 657 ++D K +LE+ Q + ++E++ + + ++ Q + L + + ++ + + + Sbjct: 3233 ELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQV 3292 Query: 658 ---SEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVR 714 SE + EM S + E + Q+ + S+ + E+ + L K L E + R Sbjct: 3293 LLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKEL--QKQLEEKHSR 3350 Query: 715 SIENERDTLEFEMRHLQ 731 +E +T ++++ LQ Sbjct: 3351 IVELLNETEKYKLDSLQ 3367 >gi|42794779 myosin 18A isoform b [Homo sapiens] Length = 2039 Score = 76.3 bits (186), Expect = 1e-13 Identities = 87/424 (20%), Positives = 187/424 (44%), Gaps = 52/424 (12%) Query: 354 EMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELES 413 E KD + F K S+ +E + S S E +AK++ L+ V+ Q++ ++ ++ Sbjct: 1503 EEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQA 1562 Query: 414 ENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEE----KSTIQSKLSKTEEYSKECLK 469 + + + K + + + +T+ K++++ EE + + Q KL + E +E + Sbjct: 1563 GTIQMLEQAK--LRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYE 1620 Query: 470 EFKKIISKYNVLQGQNKTLE----------EKNIQLSLEKQQMMEA-------------- 505 + +K++ + L+G+ TL EK ++ L++ + + A Sbjct: 1621 DKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAP 1680 Query: 506 ----LDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKE 561 + QLK++ +++ A M +E+E + I I K LE++ +L +E Sbjct: 1681 SKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQRE 1740 Query: 562 KSSLGNELKESQLEIIQLKEKERLAKTE-QETLLQI------IETVKDEKLNLETTLQ-- 612 K+ + N L+E Q ++ +L +K + A + L QI +E EK L+ LQ Sbjct: 1741 KNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQAL 1800 Query: 613 --------ESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKEC 664 +S + ++ R+ I+ ++ E Q +K +S AS K ++ ++ +E Sbjct: 1801 QSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQ-VKRLESLASRLKENMEKLTEER 1859 Query: 665 EMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLE 724 + K N+ L+ +L+ +E + + + K LE + S+E +L+ Sbjct: 1860 DQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQ 1919 Query: 725 FEMR 728 +++ Sbjct: 1920 ADLK 1923 Score = 55.1 bits (131), Expect = 3e-07 Identities = 90/427 (21%), Positives = 178/427 (41%), Gaps = 73/427 (17%) Query: 374 NEKTSKVNSVTEQCVAKIQYLQNYLKESVQ------IQKKVMELESENLNLKSKMKPLIF 427 +E+TS+ ++ + Q++ K +Q +QK + +N +K +F Sbjct: 1185 DEQTSRNLTLFQAACRGYLARQHFKKRKIQDLAIRCVQKNI----KKNKGVKDWPWWKLF 1240 Query: 428 TTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKT 487 TT + +V+ E+Q++N EE ++SKL K E+ E ++ S+ + L ++ Sbjct: 1241 TTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISEL--TSEL 1298 Query: 488 LEEKNIQLSLEKQQMMEALDQLKS----KEHKTQSDMAIVNNENNRMSIEMEAMKTNILL 543 +E+N S + E ++L++ KE +TQ D + +EME M+ ++ Sbjct: 1299 TDERNTGESASQLLDAETAERLRAEKEMKELQTQYDAL----KKQMEVMEMEVMEARLIR 1354 Query: 544 --------------------------------------IQDEKEMLEKKTHQLLKEKSSL 565 +D+ E+ ++ QL + L Sbjct: 1355 AAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDL 1414 Query: 566 GNELKESQLEIIQLKEK-ERLAKTEQETLLQII-ETVKDEKLNLETTLQESTAARQIMER 623 + +ESQ + QLK+K +RL Q+T L + + V++ +L + +S ++ E Sbjct: 1415 QADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEA 1474 Query: 624 EIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKE 683 + E +Q + E++ L +EA K L E + ++ V+ L+ Sbjct: 1475 QREKLQREKLQREKDML------LAEAFSLKQQLEEKDMDIAGFTQKVVS-------LEA 1521 Query: 684 ELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICN 743 EL+ S + K E S++++ + LE V+ E E D ++ L++ L L ++ Sbjct: 1522 ELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMER 1581 Query: 744 QHNDPSK 750 SK Sbjct: 1582 MRQTHSK 1588 >gi|28416946 myosin 18A isoform a [Homo sapiens] Length = 2054 Score = 76.3 bits (186), Expect = 1e-13 Identities = 87/424 (20%), Positives = 187/424 (44%), Gaps = 52/424 (12%) Query: 354 EMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELES 413 E KD + F K S+ +E + S S E +AK++ L+ V+ Q++ ++ ++ Sbjct: 1503 EEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQA 1562 Query: 414 ENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEE----KSTIQSKLSKTEEYSKECLK 469 + + + K + + + +T+ K++++ EE + + Q KL + E +E + Sbjct: 1563 GTIQMLEQAK--LRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYE 1620 Query: 470 EFKKIISKYNVLQGQNKTLE----------EKNIQLSLEKQQMMEA-------------- 505 + +K++ + L+G+ TL EK ++ L++ + + A Sbjct: 1621 DKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAP 1680 Query: 506 ----LDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKE 561 + QLK++ +++ A M +E+E + I I K LE++ +L +E Sbjct: 1681 SKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQRE 1740 Query: 562 KSSLGNELKESQLEIIQLKEKERLAKTE-QETLLQI------IETVKDEKLNLETTLQ-- 612 K+ + N L+E Q ++ +L +K + A + L QI +E EK L+ LQ Sbjct: 1741 KNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQAL 1800 Query: 613 --------ESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKEC 664 +S + ++ R+ I+ ++ E Q +K +S AS K ++ ++ +E Sbjct: 1801 QSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQ-VKRLESLASRLKENMEKLTEER 1859 Query: 665 EMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLE 724 + K N+ L+ +L+ +E + + + K LE + S+E +L+ Sbjct: 1860 DQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQ 1919 Query: 725 FEMR 728 +++ Sbjct: 1920 ADLK 1923 Score = 55.1 bits (131), Expect = 3e-07 Identities = 90/427 (21%), Positives = 178/427 (41%), Gaps = 73/427 (17%) Query: 374 NEKTSKVNSVTEQCVAKIQYLQNYLKESVQ------IQKKVMELESENLNLKSKMKPLIF 427 +E+TS+ ++ + Q++ K +Q +QK + +N +K +F Sbjct: 1185 DEQTSRNLTLFQAACRGYLARQHFKKRKIQDLAIRCVQKNI----KKNKGVKDWPWWKLF 1240 Query: 428 TTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKT 487 TT + +V+ E+Q++N EE ++SKL K E+ E ++ S+ + L ++ Sbjct: 1241 TTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISEL--TSEL 1298 Query: 488 LEEKNIQLSLEKQQMMEALDQLKS----KEHKTQSDMAIVNNENNRMSIEMEAMKTNILL 543 +E+N S + E ++L++ KE +TQ D + +EME M+ ++ Sbjct: 1299 TDERNTGESASQLLDAETAERLRAEKEMKELQTQYDAL----KKQMEVMEMEVMEARLIR 1354 Query: 544 --------------------------------------IQDEKEMLEKKTHQLLKEKSSL 565 +D+ E+ ++ QL + L Sbjct: 1355 AAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDL 1414 Query: 566 GNELKESQLEIIQLKEK-ERLAKTEQETLLQII-ETVKDEKLNLETTLQESTAARQIMER 623 + +ESQ + QLK+K +RL Q+T L + + V++ +L + +S ++ E Sbjct: 1415 QADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEA 1474 Query: 624 EIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKE 683 + E +Q + E++ L +EA K L E + ++ V+ L+ Sbjct: 1475 QREKLQREKLQREKDML------LAEAFSLKQQLEEKDMDIAGFTQKVVS-------LEA 1521 Query: 684 ELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICN 743 EL+ S + K E S++++ + LE V+ E E D ++ L++ L L ++ Sbjct: 1522 ELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMER 1581 Query: 744 QHNDPSK 750 SK Sbjct: 1582 MRQTHSK 1588 >gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] Length = 1417 Score = 76.3 bits (186), Expect = 1e-13 Identities = 146/743 (19%), Positives = 297/743 (39%), Gaps = 126/743 (16%) Query: 47 ENQIQPQSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVE 106 E +I S++ +LE + + ++++ + E + + FE +K +H + Sbjct: 707 EEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLA----FEKAKKIHLEQ 762 Query: 107 EKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIII--HPSENSDIL------- 157 K + L + Q E T+ L +II H E+ D L Sbjct: 763 HKEMEKQIERLEAQLEKKDQQFKEQEKTMSM----LQQDIICKQHHLESLDRLLTESKGE 818 Query: 158 -KNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQ 216 K N A N +S+ +T+ + + + K +L+ + + ++ +++L+ Sbjct: 819 MKKENMKKDEALKALQNQVSE-ETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLK 877 Query: 217 KSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRIS 276 K + L EL+ + Q + +++E + ED ++K Sbjct: 878 KKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEK 937 Query: 277 ELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKF 336 ++ L ++L RE+ ++ RK ++ +S H + K K I +TG Sbjct: 938 QVSKLEQELQKQRESSAEK----LRKMEEKCESAAHEA--DLKRQKVIELTG-------- 983 Query: 337 HSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKT--SKVNSVTEQCVAKIQYL 394 R +DQ K E+ E++ +K+ EN+ S+++ + +Q +++ Sbjct: 984 ---TARQVKIEMDQYKEELSKMEKEIMHLKRDG---ENKAMHLSQLDMILDQTKTELEKK 1037 Query: 395 QNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQ 454 N +KE ++Q E+E T++L QK E E +L+N E ++ Sbjct: 1038 TNAVKELEKLQHST---ETE-------------LTEAL-QKREVLETELQNAHGE---LK 1077 Query: 455 SKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKS--- 511 S L + +E K + KY ++ L E +++ +KQ+++E LK Sbjct: 1078 STLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNW 1137 Query: 512 ----------------KEHKTQSDMAIVNNENNRMSIEMEAMKTNILL------IQDEKE 549 +EH+ + + I+ E E+E + N + +Q+ KE Sbjct: 1138 ELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKE 1197 Query: 550 MLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQE----------TLLQIIET 599 L +K +L+ + + KE + ++KE E + K +++ L Q + Sbjct: 1198 QLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRL 1257 Query: 600 VKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLS- 658 +++ N T L E+ + +REIE + + L+++K E + N L+ Sbjct: 1258 TREQVQNSHTELAEARHQQVQAQREIERLSSE--------LEDMKQLSKEKDAHGNHLAE 1309 Query: 659 EIG----KECEMLSKMVMETK---TDNQILKE----ELKKHSQENIKF-------ENSIS 700 E+G +E + ++M E K + + LKE E+ H + + K+ ++S+ Sbjct: 1310 ELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQ 1369 Query: 701 RLTEDKILLENYVRSIENERDTL 723 +L E LE +E +DT+ Sbjct: 1370 QLNEQ---LEKAKLELEEAQDTV 1389 Score = 67.4 bits (163), Expect = 5e-11 Identities = 84/408 (20%), Positives = 173/408 (42%), Gaps = 61/408 (14%) Query: 375 EKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQ 434 E +K+ + + K Q LQ +E ++++ ++E + + + ++ + L + Sbjct: 309 EAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSK 368 Query: 435 KVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQ 494 + Y+K++ +E+ +Q++ E C KE NK L+E+ Sbjct: 369 AFQQYKKKVAEKLEK---VQAEEEILERNLTNCEKE--------------NKRLQERCGL 411 Query: 495 LSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKK 554 E + + E L QLK + + + + I+ +N+ + ++ + +IL ++ E LE K Sbjct: 412 YKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESE---LENK 468 Query: 555 THQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQES 614 ++L++K SL NE +E L++ + ERL +QE IE+ + E +LE + + Sbjct: 469 -DEILRDKFSLMNENRE--LKVRVAAQNERLDLCQQE-----IESSRVELRSLEKIISQL 520 Query: 615 TAARQIMEREIENIQTYQSTAEEN-----------------------FLQEIKNAKSEAS 651 R++ + + YQ ++ N ++E + K A+ Sbjct: 521 PLKRELFGFK-SYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHAN 579 Query: 652 IYKNSLSEI------GKECEMLSKMVME-TKTDNQILKEELKKHSQE--NIKFENSISRL 702 + N LS+ +E LS + E K + E +K +Q N ++E RL Sbjct: 580 LTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRL 639 Query: 703 TEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSK 750 L + IE E L+ M H ++ + +++ + ++ SK Sbjct: 640 VTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSK 687 Score = 62.8 bits (151), Expect = 1e-09 Identities = 96/461 (20%), Positives = 197/461 (42%), Gaps = 47/461 (10%) Query: 346 SFLDQTKHEMK---DKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESV 402 S DQ +H M +KERQ + E +T + E K+ + + + Sbjct: 619 SVKDQNQHTMNKQYEKERQRLVTG-----IEELRTKLIQIEAENSDLKVN-MAHRTSQFQ 672 Query: 403 QIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEE 462 IQ++++E S + L+S+M T+ Q + T EKQL+ + S+I +K ++ E+ Sbjct: 673 LIQEELLEKASNSSKLESEM------TKKCSQLL-TLEKQLEEKIVAYSSIAAKNAELEQ 725 Query: 463 YSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEAL-----DQLKSKEHKTQ 517 E ++ + + + N + EK ++ LE+ + ME QL+ K+ + + Sbjct: 726 ELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFK 785 Query: 518 SDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEII 577 ++ + + +++ L+ + K ++K+ + + +L N++ E +++ Sbjct: 786 EQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVR 845 Query: 578 QLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIE-NIQTYQSTAE 636 QL + K E L+ + ++ K E L++ + +++E++ + Q T+E Sbjct: 846 QLDSALEICKEE---LVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSE 902 Query: 637 ENF-----LQEIKNAKSEASIYKNSLSEIGKECE-MLSKMVMETKTDNQILKEELKKHSQ 690 +N LQ+ + + +I L + + E +SK+ E + + E+L+K + Sbjct: 903 QNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEE 962 Query: 691 ENIKFENSISRLTEDKILLENYVRSIENERD-------TLEFEMRHLQRE------YLSL 737 + + + I L R ++ E D +E E+ HL+R+ +LS Sbjct: 963 KCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQ 1022 Query: 738 SDKICNQHND--PSKTTYISRREKFHFDNYTHEDTSSPQSR 776 D I +Q KT + EK T E T + Q R Sbjct: 1023 LDMILDQTKTELEKKTNAVKELEKLQHSTET-ELTEALQKR 1062 Score = 61.6 bits (148), Expect = 3e-09 Identities = 111/536 (20%), Positives = 222/536 (41%), Gaps = 92/536 (17%) Query: 273 KRISELEALVKKLLPFRETVSKFHVHF----------CRKCKKLSKSEMHRGKKNEKNNK 322 K IS+L L ++L F+ +SK+ + C + KL SE+ Sbjct: 515 KIISQLP-LKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELR---------- 563 Query: 323 EIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQ-----GSIISENEKT 377 I + K K H+ + LS T ++ ++ + L + G ++E+ K Sbjct: 564 -IKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKD 622 Query: 378 SKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVE 437 +++ +Q + Q L ++E ++ K++++E+EN +LK M T+Q + + E Sbjct: 623 QNQHTMNKQYEKERQRLVTGIEE---LRTKLIQIEAENSDLKVNMAHR--TSQFQLIQEE 677 Query: 438 TYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSL 497 EK S ++S+++K K + L K LEEK + S Sbjct: 678 LLEK-----ASNSSKLESEMTK-----------------KCSQLLTLEKQLEEKIVAYSS 715 Query: 498 EKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEM------- 550 + E +L K K +S +N E+ ++ + E K + ++ KEM Sbjct: 716 IAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFE--KAKKIHLEQHKEMEKQIERL 773 Query: 551 ---LEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLN- 606 LEKK Q +++ ++ ++ + L+ +RL TE + ++ KDE L Sbjct: 774 EAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLL-TESKGEMKKENMKKDEALKA 832 Query: 607 LETTLQEST-------AARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSE 659 L+ + E T +A +I + E+ +E F +++K E Sbjct: 833 LQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYC------- 885 Query: 660 IGKECEMLSKMVMETKTDNQILKEELKKHSQ-------ENIKFENSISRLTEDKILLENY 712 + KE ++ + + ET N IL+ L++ Q N + E++ ++L + LE Sbjct: 886 LQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLE-- 943 Query: 713 VRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRREKFHFDNYTHE 768 + ++ +R++ ++R ++ + S + + + + T +R+ K D Y E Sbjct: 944 -QELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEE 998 Score = 44.7 bits (104), Expect = 3e-04 Identities = 81/424 (19%), Positives = 172/424 (40%), Gaps = 86/424 (20%) Query: 413 SENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFK 472 S+ N ++ + L+ SL +++ E L++L EE S++ S+ +Y+ + K Sbjct: 124 SDYYNKDNEEESLLANVASLRHELKITEWSLQSLGEELSSVSP--SENSDYAPNPSRSEK 181 Query: 473 KIISKYNVLQGQ-NKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMS 531 I+ G N + E ++S + D K K S A V+ E Sbjct: 182 LILDVQPSHPGLLNYSPYENVCKIS------GSSTDFQKKPRDKMFSSSAPVDQE----- 230 Query: 532 IEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLA----- 586 +++++ + ++ + L + H L+ + S+ EL +S+ ++ L+ ++ A Sbjct: 231 --IKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPI 288 Query: 587 ------------------------KTEQETLL-----QIIETVKDEKLNLETTLQESTAA 617 K EQ + Q ++ K+E + L+ L E T Sbjct: 289 LEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQ 348 Query: 618 RQIMERE-------IENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKM 670 + ER+ E + ++ ++++ ++E I + +L+ KE + L + Sbjct: 349 GKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQER 408 Query: 671 VMETKTDNQILKEELKKHSQEN-----------IKFENSISRLTEDKILLENYVRSIEN- 718 K++ +ILKE+L++ +EN +K +++LTE + + +EN Sbjct: 409 CGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENK 468 Query: 719 -----ERDTLEFEMRHLQREYLSLSDK--ICNQHNDPSKTTYIS----------RREKFH 761 ++ +L E R L+ + +++ +C Q + S+ S +RE F Sbjct: 469 DEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFG 528 Query: 762 FDNY 765 F +Y Sbjct: 529 FKSY 532 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.309 0.125 0.330 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 26,923,609 Number of Sequences: 37866 Number of extensions: 1196386 Number of successful extensions: 11944 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 325 Number of HSP's successfully gapped in prelim test: 1017 Number of HSP's that attempted gapping in prelim test: 5653 Number of HSP's gapped (non-prelim): 3875 length of query: 796 length of database: 18,247,518 effective HSP length: 110 effective length of query: 686 effective length of database: 14,082,258 effective search space: 9660428988 effective search space used: 9660428988 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.7 bits) S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.