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Search of human proteins with 224586823
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|224586823 coiled-coil domain containing 110 isoform b [Homo
sapiens]
(796 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|224586823 coiled-coil domain containing 110 isoform b [Homo s... 1557 0.0
gi|22749515 coiled-coil domain containing 110 isoform a [Homo sa... 1539 0.0
gi|55770834 centromere protein F [Homo sapiens] 108 2e-23
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 95 2e-19
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 95 3e-19
gi|71061468 centromere protein E [Homo sapiens] 94 5e-19
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 93 8e-19
gi|41872583 Rho-associated, coiled-coil containing protein kinas... 92 2e-18
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 89 2e-17
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 88 4e-17
gi|38044112 restin isoform b [Homo sapiens] 83 9e-16
gi|4506751 restin isoform a [Homo sapiens] 83 9e-16
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 82 1e-15
gi|58530840 desmoplakin isoform I [Homo sapiens] 82 2e-15
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 81 3e-15
gi|217272802 hyaluronan-mediated motility receptor isoform a [Ho... 81 3e-15
gi|217272804 hyaluronan-mediated motility receptor isoform d [Ho... 81 4e-15
gi|109255234 centrosomal protein 290kDa [Homo sapiens] 80 6e-15
gi|31982906 cingulin-like 1 [Homo sapiens] 80 6e-15
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens] 80 6e-15
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 80 1e-14
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 79 1e-14
gi|109134347 NY-REN-58 antigen [Homo sapiens] 77 5e-14
gi|109134355 NY-REN-58 antigen [Homo sapiens] 77 5e-14
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 77 6e-14
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 76 1e-13
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 76 1e-13
gi|42794779 myosin 18A isoform b [Homo sapiens] 76 1e-13
gi|28416946 myosin 18A isoform a [Homo sapiens] 76 1e-13
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 76 1e-13
>gi|224586823 coiled-coil domain containing 110 isoform b [Homo
sapiens]
Length = 796
Score = 1557 bits (4032), Expect = 0.0
Identities = 796/796 (100%), Positives = 796/796 (100%)
Query: 1 MSPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQ 60
MSPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQ
Sbjct: 1 MSPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQ 60
Query: 61 QQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQS 120
QQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQS
Sbjct: 61 QQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQS 120
Query: 121 VNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADT 180
VNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADT
Sbjct: 121 VNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADT 180
Query: 181 VILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHR 240
VILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHR
Sbjct: 181 VILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHR 240
Query: 241 NGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFC 300
NGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFC
Sbjct: 241 NGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFC 300
Query: 301 RKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKER 360
RKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKER
Sbjct: 301 RKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKER 360
Query: 361 QPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKS 420
QPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKS
Sbjct: 361 QPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKS 420
Query: 421 KMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNV 480
KMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNV
Sbjct: 421 KMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNV 480
Query: 481 LQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTN 540
LQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTN
Sbjct: 481 LQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTN 540
Query: 541 ILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETV 600
ILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETV
Sbjct: 541 ILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETV 600
Query: 601 KDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEI 660
KDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEI
Sbjct: 601 KDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEI 660
Query: 661 GKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENER 720
GKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENER
Sbjct: 661 GKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENER 720
Query: 721 DTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRREKFHFDNYTHEDTSSPQSRPLAS 780
DTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRREKFHFDNYTHEDTSSPQSRPLAS
Sbjct: 721 DTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRREKFHFDNYTHEDTSSPQSRPLAS 780
Query: 781 DLKGYFKVKDRTLKHH 796
DLKGYFKVKDRTLKHH
Sbjct: 781 DLKGYFKVKDRTLKHH 796
>gi|22749515 coiled-coil domain containing 110 isoform a [Homo
sapiens]
Length = 833
Score = 1539 bits (3984), Expect = 0.0
Identities = 796/833 (95%), Positives = 796/833 (95%), Gaps = 37/833 (4%)
Query: 1 MSPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQ 60
MSPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQ
Sbjct: 1 MSPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQ 60
Query: 61 QQLESFQALRMQTLQNVSM-------------------------------------PTEN 83
QQLESFQALRMQTLQNVSM PTEN
Sbjct: 61 QQLESFQALRMQTLQNVSMVQSEISEILNKSIIEVENPQFSSEKNLVFGTRIEKDLPTEN 120
Query: 84 QEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLS 143
QEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLS
Sbjct: 121 QEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLS 180
Query: 144 SNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDD 203
SNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDD
Sbjct: 181 SNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDD 240
Query: 204 ICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLD 263
ICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLD
Sbjct: 241 ICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLD 300
Query: 264 GNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKE 323
GNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKE
Sbjct: 301 GNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKE 360
Query: 324 IPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSV 383
IPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSV
Sbjct: 361 IPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSV 420
Query: 384 TEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQL 443
TEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQL
Sbjct: 421 TEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQL 480
Query: 444 KNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMM 503
KNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMM
Sbjct: 481 KNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMM 540
Query: 504 EALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKS 563
EALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKS
Sbjct: 541 EALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKS 600
Query: 564 SLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMER 623
SLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMER
Sbjct: 601 SLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMER 660
Query: 624 EIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKE 683
EIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKE
Sbjct: 661 EIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKE 720
Query: 684 ELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICN 743
ELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICN
Sbjct: 721 ELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICN 780
Query: 744 QHNDPSKTTYISRREKFHFDNYTHEDTSSPQSRPLASDLKGYFKVKDRTLKHH 796
QHNDPSKTTYISRREKFHFDNYTHEDTSSPQSRPLASDLKGYFKVKDRTLKHH
Sbjct: 781 QHNDPSKTTYISRREKFHFDNYTHEDTSSPQSRPLASDLKGYFKVKDRTLKHH 833
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 108 bits (270), Expect = 2e-23
Identities = 159/730 (21%), Positives = 322/730 (44%), Gaps = 100/730 (13%)
Query: 60 QQQLESFQALRMQTLQNVSMP--TENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSL 117
++QL + L+ + +N S+ EN E L M + + ++ L + K +++ +
Sbjct: 2133 KKQLHIAEKLKERERENDSLKDKVENLERELQMSEEN--QELVILDAENSKAEVETLKTQ 2190
Query: 118 PQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQ 177
+ + ++ D +TLR+ +NL+ I + S++ K ++F L Q
Sbjct: 2191 IEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEK-----EQ 2245
Query: 178 ADTVILDKSKITVPFLKHGFCENLDDIC------HSIKQMKEELQKSHDGEVALTNELQT 231
A+ I ++SK V L++ E + + +K ++ L + E L N ++
Sbjct: 2246 AEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEK 2305
Query: 232 LQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDG---NLNEDIKSKRISELEALVKKLLPF 288
L+ + + K + + Q K + + L G NL +++ R ++ A ++
Sbjct: 2306 LRAR--LEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEA---- 2359
Query: 289 RETVSKFHVHFCRKCKKLSKSEMHRGK-------KNEKNN--KEIPITGKNITDLKFHSR 339
SK V K K ++ RG ++EK N E+ + I++L+ +
Sbjct: 2360 --ENSKGEVETL-KAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINS 2416
Query: 340 VPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLK 399
L +Q K +MK+K + Q + NE+ + +++ E C AK Q L + ++
Sbjct: 2417 SFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVE 2476
Query: 400 ----ESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQS 455
E Q+ + + E ++ + L+S + LIQ+VE +++L+ EE S +++
Sbjct: 2477 CLELEKAQLLQGLDEAKNNYIVLQSSVN-------GLIQEVEDGKQKLEKKDEEISRLKN 2529
Query: 456 KLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHK 515
++ E+ ++SK + ++G+++ +E+N++L ++ + + L+SK
Sbjct: 2530 QIQDQEQ-----------LVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNAS 2578
Query: 516 TQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLE 575
Q + ++ + + E+E K + + ++ + K +L +E + + E Q E
Sbjct: 2579 LQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEE 2638
Query: 576 IIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQI-------MERE---I 625
+ EK RLA E + LL+ I++ KD+ E TL+ S + + +E+E
Sbjct: 2639 L--SGEKNRLA-GELQLLLEEIKSSKDQL--KELTLENSELKKSLDCMHKDQVEKEGKVR 2693
Query: 626 ENIQTYQSTAEEN-------FLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVME----- 673
E I YQ E L K + E Y+ L+ +EC K+ ++
Sbjct: 2694 EEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTS-KEECLSSQKLEIDLLKSS 2752
Query: 674 -------TKTDNQILKEELKKHSQENIKFENSISRLTED-----KILLENYVRSIENERD 721
K QIL EELKK +N+K+ N + + E K+L+++ + +E E++
Sbjct: 2753 KEELNNSLKATTQIL-EELKKTKMDNLKYVNQLKKENERAQGKMKLLIKS-CKQLEEEKE 2810
Query: 722 TLEFEMRHLQ 731
L+ E+ LQ
Sbjct: 2811 ILQKELSQLQ 2820
Score = 80.1 bits (196), Expect = 7e-15
Identities = 146/706 (20%), Positives = 299/706 (42%), Gaps = 108/706 (15%)
Query: 44 AESEN---QIQP-QSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDS 99
+E EN QIQ Q L L + L SF++L + Q E + + M ++
Sbjct: 2210 SEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQ----L 2265
Query: 100 KTLHSVEEKLSGDS--VNSLPQSVNVPSQI-----HSEDTLTLRTSTDNLSSNIIIHPSE 152
K L+ L GD + + QS++ P + +S + L R D ++ +
Sbjct: 2266 KELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLK 2325
Query: 153 NS----DILKN-YNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHS 207
S D+LK N R L A N A + + SK V LK ++ + S
Sbjct: 2326 ESEHHADLLKGRVENLERELEIARTNQEHAA--LEAENSKGEVETLK----AKIEGMTQS 2379
Query: 208 IKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLN 267
++ ++ ++ + LTNELQ Q ++ I+ N ++E+ +
Sbjct: 2380 LRGLELDVVTIRSEKENLTNELQKEQERIS-------ELEIINSSFENILQEKEQE---K 2429
Query: 268 EDIKSKRISELEALVKKLLPFRETVSKFH--VHFCR----------KCKKLSKSEMHRGK 315
+K K + +E L +L E V+ H C+ +C +L K+++ +G
Sbjct: 2430 VQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGL 2489
Query: 316 KNEKNNKEIPITGKN--ITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQ--GSII 371
KNN + + N I +++ + + + K++++D+E+ + Q G
Sbjct: 2490 DEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQ 2549
Query: 372 SENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQS 431
E+ ++ ++T + KIQ LQ+ ++ +Q + L+S NL+++++ S
Sbjct: 2550 LWKEQNLELRNLTVELEQKIQVLQS---KNASLQDTLEVLQSSYKNLENELELTKMDKMS 2606
Query: 432 LIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEK 491
++KV K E + + KT E +E E ++ + +L + K+ +++
Sbjct: 2607 FVEKVN---KMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQ 2663
Query: 492 NIQLSLEKQQMMEALDQLKS----KEHKTQSDMA---------------IVNNENNRMSI 532
+L+LE ++ ++LD + KE K + ++A ++ + N + +
Sbjct: 2664 LKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEV 2723
Query: 533 EME--------------AMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLE--- 575
E++ + K I L++ KE L LK + + ELK+++++
Sbjct: 2724 EIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNS----LKATTQILEELKKTKMDNLK 2779
Query: 576 -IIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQ------IMEREIENI 628
+ QLK++ A+ + + L++ + +++EK L+ L + AA++ +M+ +++ +
Sbjct: 2780 YVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDEL 2839
Query: 629 QTYQSTAEENFLQEIKNAKSEASIYKNSL---SEIGKECEMLSKMV 671
T +E ++ K A Y + L ++ K EML V
Sbjct: 2840 TTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQV 2885
Score = 75.1 bits (183), Expect = 2e-13
Identities = 135/607 (22%), Positives = 250/607 (41%), Gaps = 107/607 (17%)
Query: 202 DDICHSIKQMKEE--LQKSHDGEVA-----LTNELQTLQTDPDVHRNGKYDMSPIHQDKM 254
+++ S+++MK+E L KSH + A L EL+ ++ + +N +M + +
Sbjct: 475 NELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQE 534
Query: 255 NFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRG 314
+++ L +N+ S + +L+ V L R+ L K E H
Sbjct: 535 TMLRD--LQEKINQQENSLTLEKLKLAVADLEKQRDCSQDL----------LKKREHHIE 582
Query: 315 KKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISEN 374
+ N+K +K + + LS L+ K E ++ + + L SEN
Sbjct: 583 QLNDKLSKT--------------EKESKALLSALELKKKEYEELKEEKTLFSCWK--SEN 626
Query: 375 EKT-SKVNSVTEQCVAKIQYLQNYLK----ESVQIQKKVMELESENLNLKSKMKPLIFTT 429
EK +++ S E +KI +L+ LK +S + ++V LE + NL +++ L
Sbjct: 627 EKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVL 686
Query: 430 QSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLE 489
S +VET +K K E ++ KE + + K + L GQ + LE
Sbjct: 687 DSKSVEVET----------QKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLE 736
Query: 490 EKNIQLS---LEKQQMMEAL--------DQLKSKEHKTQSDMAIVNNENNRMSIEMEAMK 538
K LS ++K + + L D LKSK D ++V NE+++ S
Sbjct: 737 HKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSK------DASLVTNEDHQRS------- 783
Query: 539 TNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIE 598
LL D++ + ++ E+ S+ +E E +LE Q + + + ++L +E
Sbjct: 784 ---LLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLE 840
Query: 599 TVKDEKLNLETTLQESTAAR-QIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSL 657
+ K +L+ +E + +I E ++ Q +QS E Q I + + S ++N +
Sbjct: 841 SQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETS-QRISKLQEDTSAHQNVV 899
Query: 658 SEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIE 717
+E E K + Q+L ++++ E I L + LLE+ ++ ++
Sbjct: 900 AETLSALENKEKEL-------QLLNDKVETEQAE-------IQELKKSNHLLEDSLKELQ 945
Query: 718 NERDTLEFEMRHL-------QREYLSLSD-----KICNQHNDPSKTTYISRREKFHFDNY 765
+TL E + + +RE L+ K N + K I + E F NY
Sbjct: 946 LLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSES--FANY 1003
Query: 766 THEDTSS 772
E S
Sbjct: 1004 IDEREKS 1010
Score = 74.7 bits (182), Expect = 3e-13
Identities = 93/455 (20%), Positives = 192/455 (42%), Gaps = 53/455 (11%)
Query: 348 LDQTK---HEMKDKERQPFLVKQGSIISENEKTSKVNSVTE----------QCVAKIQYL 394
LDQ K E+++K + L QG E E +VN E + + K + L
Sbjct: 280 LDQLKAQNQELRNKINELELRLQGH---EKEMKGQVNKFQELQLQLEKAKVELIEKEKVL 336
Query: 395 QNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKST-I 453
E V+ + + ++ L+ K+K L Q E+ L+ ++EK
Sbjct: 337 NKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEF 396
Query: 454 QSKLSKTEE----YSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQL 509
Q +LS+ + +EC++ ++ + + + L+ + +L+ KQQ+ L++
Sbjct: 397 QEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEF 456
Query: 510 KSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNEL 569
K K + + + N + ME MK L++ E ++ L E ++ L
Sbjct: 457 KQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCL 516
Query: 570 KESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQ 629
+SQ E+ + T QET+L+ ++ EK+N QE++ + ++ + +++
Sbjct: 517 NQSQ----NFAEEMKAKNTSQETMLRDLQ----EKIN----QQENSLTLEKLKLAVADLE 564
Query: 630 TYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHS 689
+ +++ +K + + LS+ KE + L + K + + LKEE S
Sbjct: 565 KQRDCSQD----LLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFS 620
Query: 690 QENIKFENSISRLTEDKILLENYVRSIENERDTLEFE-------MRHLQREYLSLSDKIC 742
+ E ++++ +K L++ + +E T + + +R L+ + +LS +I
Sbjct: 621 CWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIR 680
Query: 743 NQHN---------DPSKTTYISRREKFHFDNYTHE 768
N HN + K Y+ ++K F + H+
Sbjct: 681 NLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQ 715
Score = 73.6 bits (179), Expect = 7e-13
Identities = 92/411 (22%), Positives = 183/411 (44%), Gaps = 53/411 (12%)
Query: 353 HEMKDKERQPFLVKQGSIISE-NEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMEL 411
H ++D++R K S+++E E SK++ Q + KI+ ++++K V EL
Sbjct: 1788 HVIEDRDR-----KVESLLNEMKELDSKLHLQEVQLMTKIE-------ACIELEKIVGEL 1835
Query: 412 ESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNL-----VEEKSTIQSKLSKTEEYSKE 466
+ EN +L K++ Q L+Q+VET E +L + I ++K + KE
Sbjct: 1836 KKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKE 1895
Query: 467 CLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMM-EALDQLKSKEHK------TQSD 519
F + ++ + ++ + ++E + + L + + + E L K E+K + +
Sbjct: 1896 ---RFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEE 1952
Query: 520 MAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQL 579
+++V +E N++ E++ M + E +++KT +L +S L IQ+
Sbjct: 1953 LSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSEC--------LHCIQV 2004
Query: 580 KEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENF 639
E E KTE LLQ + + E L +T LQE Q +E++ + + + E
Sbjct: 2005 AEAEVKEKTE---LLQTLSSDVSELLKDKTHLQEKL---QSLEKDSQALSLTKCELENQI 2058
Query: 640 LQEIKNAK---SEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFE 696
Q K + E+ + LSE E +SK + + L +E +
Sbjct: 2059 AQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLR 2118
Query: 697 NSISRL-------TEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDK 740
I +L + ++ + ++ E E D+L+ ++ +L+RE L +S++
Sbjct: 2119 RGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERE-LQMSEE 2168
Score = 73.2 bits (178), Expect = 9e-13
Identities = 161/788 (20%), Positives = 320/788 (40%), Gaps = 156/788 (19%)
Query: 51 QPQSALKVLQQQL----ESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVE 106
Q ++ L+ +Q+L ++FQA +++ + E ++EN ++ KSH + ++ + +E
Sbjct: 448 QLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKEN-NLLKSHSEQKAREVCHLE 506
Query: 107 EKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRF 166
+L ++ Q +N SQ +E+ TS + + ++
Sbjct: 507 AELK-----NIKQCLN-QSQNFAEEMKAKNTSQETMLRDL-------------------- 540
Query: 167 LPTAPPNVMSQADTVILDKSKITVPFL-KHGFCEN--LDDICHSIKQMKEELQKSHDGEV 223
+ Q +++ L+K K+ V L K C L H I+Q+ ++L K+
Sbjct: 541 ----QEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESK 596
Query: 224 ALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFI-----KEENLDGNLNE---DIKSKRI 275
AL + L+ + + + + K S + + ++ENL +N +K+++I
Sbjct: 597 ALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQI 656
Query: 276 S--ELEALVKKLLPFRETVS----KFHVHFCRKC-----KKLSKSEMHRGKK--NEKNNK 322
E V+ L RE +S H K +KL+ E+ + + ++K+ K
Sbjct: 657 KSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQK 716
Query: 323 EIP--------ITGKNITDLKFHSRVPRYTLSFLD---QTKHEMKDKERQPFLVKQGSII 371
EI +TG+ + DL+ ++ + D Q H + R K S++
Sbjct: 717 EIENMCLKTSQLTGQ-VEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLV 775
Query: 372 SENEKTSKVNSVTEQCVAKIQYLQNYLKE--SVQIQKKVMELESE-----NLNLKSKMKP 424
+ NE + +Q A N + E S+ ++ LE++ + L++++
Sbjct: 776 T-NEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDS 834
Query: 425 LIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISK------- 477
L F+ +S Q +KQ + LV+ K I+ L K E+ + + E + ISK
Sbjct: 835 LEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSA 894
Query: 478 -YNVLQGQNKTLE--EKNIQLSLEKQQMMEA-LDQLKSKEHKTQSDMAIVNNENNRMSIE 533
NV+ LE EK +QL +K + +A + +LK H + + + + +S+E
Sbjct: 895 HQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLE 954
Query: 534 MEAMKTNILLIQDEKE--------------MLEKKTHQLLKEKSSLGNELKESQLEIIQL 579
+ M + I L + E E L ++ L+++ S N + E + I +L
Sbjct: 955 KKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISEL 1014
Query: 580 KEKERLAK-----------TEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENI 628
++ + K E L Q + +++ LE L E T+ + + E+E +
Sbjct: 1015 SDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQL 1074
Query: 629 QTYQSTAEENFLQEI-----------------------------KNAKSEASIYKNSLSE 659
+ + + FL ++ N+KSEA K +
Sbjct: 1075 KEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMT 1134
Query: 660 IGKECEMLSKMVMETKTDNQILKEELK-KHSQENIKFENSISRLTEDKILLENYVRSIEN 718
+ +E + K V + +N+ L + +K KH +N++ E + N V+ E+
Sbjct: 1135 LKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEP-----------IRNSVKERES 1183
Query: 719 ERDTLEFE 726
ER+ F+
Sbjct: 1184 ERNQCNFK 1191
Score = 71.6 bits (174), Expect = 3e-12
Identities = 134/745 (17%), Positives = 291/745 (39%), Gaps = 81/745 (10%)
Query: 35 CSDTEYGCIAESENQI---------------QPQSALKVLQQQLESFQALRMQTLQNVSM 79
C + E + NQ+ Q +K Q+LES Q+ + +Q
Sbjct: 1948 CLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEA 2007
Query: 80 PTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTST 139
+ + E L S E K ++EKL QS+ SQ S L
Sbjct: 2008 EVKEKTELLQTLSSDVSELLKDKTHLQEKL---------QSLEKDSQALSLTKCELENQI 2058
Query: 140 DNLSSN--IIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGF 197
L+ +++ SE+ + +++ + NV + +++K + +
Sbjct: 2059 AQLNKEKELLVKESESLQARLSESDYEKL------NVSKALEAALVEKGEFALRLSSTQ- 2111
Query: 198 CENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFI 257
E + + I++++ ++ ++ + +L+ + + D ++
Sbjct: 2112 -EEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKD---------------- 2154
Query: 258 KEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKN 317
K ENL+ L +++ + L+A K ET+ R K + +
Sbjct: 2155 KVENLERELQMSEENQELVILDAENSKAEV--ETLKTQIEEMARSLKVFELDLVTLRSEK 2212
Query: 318 EKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKT 377
E K+I +++L + L +Q + ++K++ + + Q + NE
Sbjct: 2213 ENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAV 2272
Query: 378 SKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMEL-------ESENLNLKSKMKPLIFTTQ 430
+ + E A Q L ++E Q++ + +L E + L + ++K
Sbjct: 2273 AALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHAD 2332
Query: 431 SLIQKVETYEKQLK--NLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTL 488
L +VE E++L+ +E + ++++ SK E E LK KI L+G L
Sbjct: 2333 LLKGRVENLERELEIARTNQEHAALEAENSKGEV---ETLKA--KIEGMTQSLRG----L 2383
Query: 489 EEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNIL-LIQDE 547
E + + EK+ + L KE + S++ I+N+ + E E K +
Sbjct: 2384 ELDVVTIRSEKENLTNELQ----KEQERISELEIINSSFENILQEKEQEKVQMKEKSSTA 2439
Query: 548 KEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNL 607
EML+ + +L + ++L N+ + + + L + + E+ LLQ ++ K+ + L
Sbjct: 2440 MEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVL 2499
Query: 608 ETT----LQESTAARQIMEREIENIQTYQSTAE--ENFLQEIKNAKSEASIYKNSLSEIG 661
+++ +QE +Q +E++ E I ++ + E + ++ + E ++K E+
Sbjct: 2500 QSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELR 2559
Query: 662 KECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERD 721
L + + ++ N L++ L+ EN + DK+ V + +
Sbjct: 2560 NLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKET 2619
Query: 722 TLEFEMRHLQREYLSLSDKICNQHN 746
L+ EM + ++ L +++ + N
Sbjct: 2620 ELQREMHEMAQKTAELQEELSGEKN 2644
Score = 63.9 bits (154), Expect = 6e-10
Identities = 168/841 (19%), Positives = 324/841 (38%), Gaps = 138/841 (16%)
Query: 17 LLSASKILNSSEGVKESGC-SDTEYGCIAESENQIQPQSALKVLQQQLESFQALRMQTLQ 75
LL+ KILN G+ D G E N+ P S + + S++ L + +
Sbjct: 1342 LLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPL--DESNSYEHLTLSDKE 1399
Query: 76 NVSMPTENQEENLSMEKSH------HFEDSKTLHSVEEKLSGDSVNSLPQSVNVPS---Q 126
E QE+ LS++ H H + S + ++ + +L S N+ +
Sbjct: 1400 VQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGD 1459
Query: 127 IHSEDTLTLRTS-TDNLSSNIIIHPSENSDILKNYNNFYRFL--PTAPPNVMSQADTVI- 182
+ E L L +LSS+ + S S + ++FYR L T +++S + +
Sbjct: 1460 LVKEMQLGLEEGLVPSLSSSCVPDSSSLSSL--GDSSFYRALLEQTGDMSLLSNLEGAVS 1517
Query: 183 -------------LDKSKIT---VPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALT 226
L + +T P E L+ +C +Q E+L++ + + +
Sbjct: 1518 ANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMK 1577
Query: 227 N-ELQTLQT-------DPDVHRNGKYDMSPIHQDKMNFI-----------KEENLDGNLN 267
N E+Q L+ + D R + Q K+ + K++ +L
Sbjct: 1578 NKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLE 1637
Query: 268 EDIKSKRISELEALVKKLLPF---------RETVSKFHVHFCRKCKKLSKSEMHRGKKNE 318
++ ++ L+ + LL E+ H ++ K ++H+ +
Sbjct: 1638 LEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKD 1697
Query: 319 KNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTS 378
+++ + + IT+ + T +E +++ QGS +E S
Sbjct: 1698 AQ-QDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKT-----QGS----SECIS 1747
Query: 379 KVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNL-------KSKMKPLIFTTQS 431
+++ + + +L N ++ +Q +V E +ENL L K++ L+ +
Sbjct: 1748 ELSFSGPNALVPMDFLGNQ-EDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKE 1806
Query: 432 LIQKVETYEKQLKNLVE---EKSTIQSKLSKTEEYSKECLKEF----KKIISKYNVLQGQ 484
L K+ E QL +E E I +L K E L+ F ++++ + +G
Sbjct: 1807 LDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGL 1866
Query: 485 NKTLEEKNIQLSLEK--QQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAM--KTN 540
N LE + S E + + D K + +++++ + +E + SIE EA+ + +
Sbjct: 1867 NSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSE--KASIEHEALYLEAD 1924
Query: 541 ILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETV 600
+ ++Q EK LEK K L EL E QL+ + + L Q+ E +
Sbjct: 1925 LEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKM 1984
Query: 601 KDEKLNLETTLQESTAARQIMEREI----ENIQTYQSTAEE---------NFLQEIKNAK 647
K++ LE+ E Q+ E E+ E +QT S E LQ ++
Sbjct: 1985 KEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDS 2044
Query: 648 SEASIYK----NSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSIS--- 700
S+ K N ++++ KE E+L K +++ L+ L + E + ++
Sbjct: 2045 QALSLTKCELENQIAQLNKEKELLVK-------ESESLQARLSESDYEKLNVSKALEAAL 2097
Query: 701 --------RLTEDKILLENYVRSIENERDTLEFE----------MRHLQREYLSLSDKIC 742
RL+ + + R IE R +E + ++ +RE SL DK+
Sbjct: 2098 VEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVE 2157
Query: 743 N 743
N
Sbjct: 2158 N 2158
Score = 37.7 bits (86), Expect = 0.042
Identities = 144/793 (18%), Positives = 316/793 (39%), Gaps = 113/793 (14%)
Query: 59 LQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLP 118
L+ Q + L+ Q + V + E +E + E+ H ++T + + S +
Sbjct: 839 LESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNV 898
Query: 119 QSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQA 178
+ + + + E L L L+ + +E ++ K+ + L + + +
Sbjct: 899 VAETLSALENKEKELQL------LNDKVETEQAEIQELKKSNH----LLEDSLKELQLLS 948
Query: 179 DTVILDKSKIT-VPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPD 237
+T+ L+K +++ + L E L ++K++ L + ++ L + ++ D
Sbjct: 949 ETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQE---KMNLIQKSESFANYID 1005
Query: 238 VHRNGKYDMSPIH-QDKMNFIKEENLDGNLNEDIKSK------RISELEALVKK------ 284
++S + Q+K+ ++ GN ED+ K + S+LE L+ +
Sbjct: 1006 EREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCE 1065
Query: 285 -----LLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSR 339
L +E +K H F K + + + E + + +TD + +S+
Sbjct: 1066 NRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALR---SEMTDNQNNSK 1122
Query: 340 VPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCV-AKIQYLQNYL 398
L T E ++K ++ + ++ ENE+ KV +C + + ++N +
Sbjct: 1123 SEAGGLKQEIMTLKEEQNKMQK----EVNDLLQENEQLMKVMKTKHECQNLESEPIRNSV 1178
Query: 399 KESVQIQ-----KKVMELESENLNLKSKMKPLIFTTQSLIQK---VETYEKQLKNLVEEK 450
KE + K M+LE + ++L S L+ L K ++ EK+ + L E
Sbjct: 1179 KERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHEL 1238
Query: 451 STIQSKLS-------KTEEYS--KECL--KEFKKIISKYNVLQGQNKTLE-EKNIQLSLE 498
TI+ L +++E S K+C E K I + + QN + ++Q ++
Sbjct: 1239 QTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMN 1298
Query: 499 KQQMMEALDQ-LKSKEHKTQSDMAIVNNE----NNRMSIEMEAMKTNILLIQDEKEMLE- 552
K +E + + L++++++ +++ +E +M+ E+ + + ++ D+ +L
Sbjct: 1299 KLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHG 1358
Query: 553 ---------------KKTHQL----LKEKSS---LGNELKESQLEIIQLKEKERLAKTEQ 590
+ H + L E +S L KE Q+ +L+EK ++E
Sbjct: 1359 ELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEH 1418
Query: 591 ETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQ-----TYQSTAEENFLQEIK- 644
+ L + + L+T + A ++ + N Q Q EE + +
Sbjct: 1419 KILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSS 1478
Query: 645 ---------NAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEEL--KKHSQENI 693
++ ++S Y+ L + G + +LS + NQ +E+ +EN+
Sbjct: 1479 SCVPDSSSLSSLGDSSFYRALLEQTG-DMSLLSNLEGAVSA-NQCSVDEVFCSSLQEENL 1536
Query: 694 KFENSISR----LTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICN--QHND 747
+ + S + E + L E Y +S+E + +E + +E L + + Q D
Sbjct: 1537 TRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELD 1596
Query: 748 PSKTTYISRREKF 760
+ Y+S E++
Sbjct: 1597 CLRKQYLSENEQW 1609
Score = 36.6 bits (83), Expect = 0.094
Identities = 57/307 (18%), Positives = 123/307 (40%), Gaps = 22/307 (7%)
Query: 433 IQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKN 492
+QK++ E QL L +EK Q +L E + K+ +K+ +N+ E N
Sbjct: 17 LQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQ---KQKQKV---------ENEKTEGTN 64
Query: 493 IQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDE----K 548
L E Q++ME + L+ + K ++ + ++ N ++ + K I ++ E K
Sbjct: 65 --LKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCK 122
Query: 549 EMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLE 608
LE+ SL ++ L + + ++ E L + +E+ LE
Sbjct: 123 SELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLE 182
Query: 609 TTLQ--ESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEM 666
++ ++ A Q + + N + + + + K+ + + NS +
Sbjct: 183 AEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFS 242
Query: 667 LSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFE 726
S E + ++ K + F+NS S D++ +N + + N+ + LE
Sbjct: 243 ASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQN--QELRNKINELELR 300
Query: 727 MRHLQRE 733
++ ++E
Sbjct: 301 LQGHEKE 307
Score = 34.7 bits (78), Expect = 0.36
Identities = 53/228 (23%), Positives = 87/228 (38%), Gaps = 25/228 (10%)
Query: 551 LEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETT 610
LE + +L KEK +L + + + K+K KTE L + + + + +LE T
Sbjct: 23 LEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEKT 82
Query: 611 LQESTAARQIMEREIENIQTYQSTAE----ENFLQEIKNAKSEASIYKNSLSEIG---KE 663
Q+ + Q+ E ++ N Q Q + E QE+K KSE + +
Sbjct: 83 KQKISHELQVKESQV-NFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNP 141
Query: 664 CEMLSKMVMETKTDNQI--------LKEELKKHSQENIKFENSISRLTEDKILLENYVRS 715
C K+ T +Q LKE+ K +E + E + L + K + ++
Sbjct: 142 CNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKAL-QAKKASQTLPQA 200
Query: 716 IENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRREKFHFD 763
N RD + R S S Q PS + S+R D
Sbjct: 201 TMNHRD--------IARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRD 240
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 95.1 bits (235), Expect = 2e-19
Identities = 173/821 (21%), Positives = 336/821 (40%), Gaps = 104/821 (12%)
Query: 45 ESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKS-HHFEDSKTLH 103
E EN+I +S +K +L + + Q + + E E +E HH E L
Sbjct: 586 EKENKILHES-IKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELL 644
Query: 104 S---VEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRT--STDNLSSNIIIHPSENSDILK 158
K++ + + +L Q S++ E+ +T S NL+ + ENS + +
Sbjct: 645 QKKITNLKITCEKIEALEQE---NSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDE 701
Query: 159 NYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKS 218
R + + M A + +K + K + L+ + S K+ E L+ S
Sbjct: 702 ENLELRRNVESLKCASMKMAQLQLENKE---LESEKEQLKKGLELLKASFKKT-ERLEVS 757
Query: 219 HDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNF-IKEENLDGNLNE-DIKSKRIS 276
+ G L E Q LQ + N + + + + ++ + L NL E I SKR+
Sbjct: 758 YQG---LDIENQRLQKTLE---NSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLE 811
Query: 277 ELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKF 336
+LE K L + K ++ K+L + + E+NN +I K L
Sbjct: 812 QLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSK 871
Query: 337 HSRVPRYTLSFLDQTKHEMKDKERQP------FLVKQGSIISENEKTSKVNSVTEQCVAK 390
+ + + L + + E K+ ++ + + ++SE KT ++N+ E+ +
Sbjct: 872 EIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHE 931
Query: 391 IQY-------------------------LQNYLKESVQI-QKKVMELES---ENLNLKSK 421
++ L++ LK+S++I ++K+ LE+ E+ N +
Sbjct: 932 LEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQ 991
Query: 422 MKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVL 481
++ + T + + ++ + + + +V+ I + +K E S+E +E K+ + +
Sbjct: 992 LRQELKTVKKNYEALKQRQDE-ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEV 1050
Query: 482 QGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNI 541
+ N TL+ + L + +Q+ + L+++ Q + +N + + ++
Sbjct: 1051 ERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVEN 1110
Query: 542 LLIQDEKEMLEKKTHQLLKEKSSLGNE----LKESQ----LEIIQLKEKERL------AK 587
+ + L + QLL ++SSL NE +KE + L +K+ E+L
Sbjct: 1111 STLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQA 1170
Query: 588 TEQETLLQIIETVKDEKLNLETTLQE-STAARQIMER--EIENIQTYQSTAEENFLQEIK 644
+E E+L+ T+K NLE ++ Q++++ ++E+++ +E L E K
Sbjct: 1171 SEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENK 1230
Query: 645 NAKSEASIYKNSLSEIGKECEMLSKMVMET---KTDNQILKEELKKHSQENIKFENSISR 701
N ++ A+ YK E + S+++ ET +TD++ LK L E + E S+
Sbjct: 1231 NHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSK 1290
Query: 702 LTED-------KILLENYVRSIENERDTLEFEMRHL--QREYLSLSDKICNQHNDPSK-- 750
L E L N + + LE E RHL Q + L L ++ + N SK
Sbjct: 1291 LKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDL 1350
Query: 751 -----TTYISR-------REKFH---FDNYTHEDTSSPQSR 776
YI + +EK D Y D S P+ R
Sbjct: 1351 FHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRR 1391
Score = 77.4 bits (189), Expect = 5e-14
Identities = 78/367 (21%), Positives = 167/367 (45%), Gaps = 39/367 (10%)
Query: 394 LQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTI 453
L++ L+ + K+ ELE ENL LK+K+ + + + K+++ L+EE T+
Sbjct: 363 LEDQLEGTRARSDKLHELEKENLQLKAKL-------HDMEMERDMDRKKIEELMEENMTL 415
Query: 454 QSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTL--------EEKNIQLSLEKQQMMEA 505
+ ++ + S E ++I + + K+L + ++L +E Q + +
Sbjct: 416 EMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKT 475
Query: 506 LDQLKSKEHKTQ---SDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEK 562
+++L++ + S + + EN R+S ++E ++ I+ + + + + L+KEK
Sbjct: 476 VEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEK 535
Query: 563 SSLGNELKESQLEIIQLKEKERLAKTEQET--LLQIIETVKD-EKLNLETTLQESTAARQ 619
+ L E +E ++ + ++ EQE L Q + +++ +++ E +++ +
Sbjct: 536 AQL-----EKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENK 590
Query: 620 IMEREIENIQTYQSTAE------ENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVME 673
I+ I+ + S E + L+ K A +N L + KE E+L K +
Sbjct: 591 ILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKI-- 648
Query: 674 TKTDNQILKEELKKHSQENIKFENSISRLTEDKILLEN---YVRSIENERDTLEFEMRHL 730
T+ +I E+++ QEN + E +L + +N + S+E E L+ E L
Sbjct: 649 --TNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLEL 706
Query: 731 QREYLSL 737
+R SL
Sbjct: 707 RRNVESL 713
Score = 72.4 bits (176), Expect = 2e-12
Identities = 149/691 (21%), Positives = 284/691 (41%), Gaps = 145/691 (20%)
Query: 199 ENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIK 258
E L DI K EEL++ D +V L E +T+ D + + + DK++ ++
Sbjct: 334 ERLHDI-EFYKARVEELKE--DNQVLL--ETKTMLED-------QLEGTRARSDKLHELE 381
Query: 259 EENL-------DGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSK-SE 310
+ENL D + D+ K+I EL L ++ +H + +++S+ SE
Sbjct: 382 KENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSE 441
Query: 311 MHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSI 370
+ + ++ +T + L+ ++ L +T E++
Sbjct: 442 LSEAPQKSLGHEVNELTSSRLLKLEMENQS-------LTKTVEELR-------------- 480
Query: 371 ISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENL-------NLKSKMK 423
+ V+SV E +KI ++ KE+ ++ KKV LE+E + N ++ K
Sbjct: 481 -------TTVDSV-EGNASKILKME---KENQRLSKKVEILENEIVQEKQSLQNCQNLSK 529
Query: 424 PLIFTTQSLIQKVETY----EKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYN 479
L+ L + +ET E+Q+K L +E + +S + S+ + K I K N
Sbjct: 530 DLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKEN 589
Query: 480 -VLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMK 538
+L K K ++ EK+Q+ + L+ K K + + + NE + + E E ++
Sbjct: 590 KILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEE----LENELHHLEKENELLQ 645
Query: 539 ---TNILLIQDEKEMLE-------------KKT-----------HQLLKEKSSLGNE--- 568
TN+ + ++ E LE KKT L KE S L E
Sbjct: 646 KKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLE 705
Query: 569 -------LKESQLEIIQLKEKERLAKTEQETLLQIIETVKD-----------------EK 604
LK + +++ QL+ + + ++E+E L + +E +K E
Sbjct: 706 LRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIEN 765
Query: 605 LNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKEC 664
L+ TL+ S Q +E E+++++ T ++N L+E+K + + + +E
Sbjct: 766 QRLQKTLENSNKKIQQLESELQDLEMENQTLQKN-LEELKISSKRLEQLEKENKSLEQET 824
Query: 665 EMLSKMVMETKTDNQILKE--ELKKHSQE--NIKFEN----SISRLTEDKILLENYVRSI 716
L K + + +N+ L++ E+K + E N+K N + + E I E+ VR
Sbjct: 825 SQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLK 884
Query: 717 ENERDTLEFEMR---------HLQREYLSLSDKICNQHNDPSKTTYISRREKFHFDNYTH 767
E E++ E R L+ + +S K +ND K T+ + + + H
Sbjct: 885 ELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLH 944
Query: 768 EDTSSPQ-----SRPLASDLKGYFKVKDRTL 793
++ S+ L S LK ++K+ +
Sbjct: 945 DEQSTDDRYKLLESKLESTLKKSLEIKEEKI 975
Score = 70.1 bits (170), Expect = 8e-12
Identities = 95/412 (23%), Positives = 185/412 (44%), Gaps = 65/412 (15%)
Query: 378 SKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVE 437
+K+ + ++ K + L + +E Q++ ++ L+ EN+NL S + L +
Sbjct: 258 AKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDEL-DALR 316
Query: 438 TYEKQLKNLVEEKSTIQSKLSKTEEYSK--ECLKEFKKIISKYNVLQGQNKTLEEKNIQL 495
++ L E S + +L E Y E LKE +++ + KT+ E ++
Sbjct: 317 EKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLL-------ETKTMLEDQLEG 369
Query: 496 SLEKQQMMEALD----QLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEML 551
+ + + L+ QLK+K H + + + +R IE E M+ N+ L +K+ +
Sbjct: 370 TRARSDKLHELEKENLQLKAKLHDME-----MERDMDRKKIE-ELMEENMTLEMAQKQSM 423
Query: 552 EKKTH------QLLK-------EKSSLG---NELKESQLEIIQLKEKERLAKTEQE--TL 593
++ H Q+ + + SLG NEL S+L +++ E + L KT +E T
Sbjct: 424 DESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEM-ENQSLTKTVEELRTT 482
Query: 594 LQIIETVKDEKLNLETTLQESTAARQIMEREI----ENIQTYQS---------------- 633
+ +E + L +E Q + +I+E EI +++Q Q+
Sbjct: 483 VDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTI 542
Query: 634 -TAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSK-MVMETKTDNQILKEELKKHSQE 691
T EN ++IK + E ++S + + ++ ++ V + + +N+IL E +K+ S +
Sbjct: 543 ETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSK 602
Query: 692 NIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICN 743
K E ++ ++ LE+Y E + LE E+ HL++E L KI N
Sbjct: 603 LSKIEFEKRQIKKE---LEHYKEKGERAEE-LENELHHLEKENELLQKKITN 650
Score = 41.6 bits (96), Expect = 0.003
Identities = 55/207 (26%), Positives = 89/207 (42%), Gaps = 21/207 (10%)
Query: 530 MSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGN---ELKESQLEIIQLKEKERLA 586
+S+E+ K I ++ E LE+KT QLL K L ELK Q E + L R A
Sbjct: 249 LSVELADAKAKIRRLRQE---LEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSA 305
Query: 587 KTEQETLLQIIE-TVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKN 645
+ ++ L + E V+ +KL ES +R + + +I+ Y++ EE L+E
Sbjct: 306 RMYRDELDALREKAVRVDKL-------ESEVSR--YKERLHDIEFYKARVEE--LKEDNQ 354
Query: 646 AKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTED 705
E K L + + S + E + +N LK +L E I L E+
Sbjct: 355 VLLET---KTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEE 411
Query: 706 KILLENYVRSIENERDTLEFEMRHLQR 732
+ LE + +E L +E+ + R
Sbjct: 412 NMTLEMAQKQSMDESLHLGWELEQISR 438
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 94.7 bits (234), Expect = 3e-19
Identities = 173/822 (21%), Positives = 336/822 (40%), Gaps = 105/822 (12%)
Query: 45 ESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKS-HHFEDSKTLH 103
E EN+I +S +K +L + + Q + + E E +E HH E L
Sbjct: 586 EKENKILHES-IKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELL 644
Query: 104 S---VEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRT--STDNLSSNIIIHPSENSDILK 158
K++ + + +L Q S++ E+ +T S NL+ + ENS + +
Sbjct: 645 QKKITNLKITCEKIEALEQE---NSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDE 701
Query: 159 NYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKS 218
R + + M A + +K + K + L+ + S K+ E L+ S
Sbjct: 702 ENLELRRNVESLKCASMKMAQLQLENKE---LESEKEQLKKGLELLKASFKKT-ERLEVS 757
Query: 219 HDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNF-IKEENLDGNLNE-DIKSKRIS 276
+ G L E Q LQ + N + + + + ++ + L NL E I SKR+
Sbjct: 758 YQG---LDIENQRLQKTLE---NSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLE 811
Query: 277 ELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKF 336
+LE K L + K ++ K+L + + E+NN +I K L
Sbjct: 812 QLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSK 871
Query: 337 HSRVPRYTLSFLDQTKHEMKDKERQP------FLVKQGSIISENEKTSKVNSVTEQCVAK 390
+ + + L + + E K+ ++ + + ++SE KT ++N+ E+ +
Sbjct: 872 EIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHE 931
Query: 391 IQY--------------------------LQNYLKESVQI-QKKVMELES---ENLNLKS 420
++ L++ LK+S++I ++K+ LE+ E+ N
Sbjct: 932 LEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQ 991
Query: 421 KMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNV 480
+++ + T + + ++ + + + +V+ I + +K E S+E +E K+ +
Sbjct: 992 QLRQELKTVKKNYEALKQRQDE-ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIE 1050
Query: 481 LQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTN 540
++ N TL+ + L + +Q+ + L+++ Q + +N + + ++
Sbjct: 1051 VERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVE 1110
Query: 541 ILLIQDEKEMLEKKTHQLLKEKSSLGNE----LKESQ----LEIIQLKEKERL------A 586
+ + L + QLL ++SSL NE +KE + L +K+ E+L
Sbjct: 1111 NSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQ 1170
Query: 587 KTEQETLLQIIETVKDEKLNLETTLQE-STAARQIMER--EIENIQTYQSTAEENFLQEI 643
+E E+L+ T+K NLE ++ Q++++ ++E+++ +E L E
Sbjct: 1171 ASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLEN 1230
Query: 644 KNAKSEASIYKNSLSEIGKECEMLSKMVMET---KTDNQILKEELKKHSQENIKFENSIS 700
KN ++ A+ YK E + S+++ ET +TD++ LK L E + E S
Sbjct: 1231 KNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFS 1290
Query: 701 RLTED-------KILLENYVRSIENERDTLEFEMRHL--QREYLSLSDKICNQHNDPSK- 750
+L E L N + + LE E RHL Q + L L ++ + N SK
Sbjct: 1291 KLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKD 1350
Query: 751 ------TTYISR-------REKFH---FDNYTHEDTSSPQSR 776
YI + +EK D Y D S P+ R
Sbjct: 1351 LFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRR 1392
Score = 77.4 bits (189), Expect = 5e-14
Identities = 78/367 (21%), Positives = 167/367 (45%), Gaps = 39/367 (10%)
Query: 394 LQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTI 453
L++ L+ + K+ ELE ENL LK+K+ + + + K+++ L+EE T+
Sbjct: 363 LEDQLEGTRARSDKLHELEKENLQLKAKL-------HDMEMERDMDRKKIEELMEENMTL 415
Query: 454 QSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTL--------EEKNIQLSLEKQQMMEA 505
+ ++ + S E ++I + + K+L + ++L +E Q + +
Sbjct: 416 EMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKT 475
Query: 506 LDQLKSKEHKTQ---SDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEK 562
+++L++ + S + + EN R+S ++E ++ I+ + + + + L+KEK
Sbjct: 476 VEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEK 535
Query: 563 SSLGNELKESQLEIIQLKEKERLAKTEQET--LLQIIETVKD-EKLNLETTLQESTAARQ 619
+ L E +E ++ + ++ EQE L Q + +++ +++ E +++ +
Sbjct: 536 AQL-----EKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENK 590
Query: 620 IMEREIENIQTYQSTAE------ENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVME 673
I+ I+ + S E + L+ K A +N L + KE E+L K +
Sbjct: 591 ILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKI-- 648
Query: 674 TKTDNQILKEELKKHSQENIKFENSISRLTEDKILLEN---YVRSIENERDTLEFEMRHL 730
T+ +I E+++ QEN + E +L + +N + S+E E L+ E L
Sbjct: 649 --TNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLEL 706
Query: 731 QREYLSL 737
+R SL
Sbjct: 707 RRNVESL 713
Score = 75.9 bits (185), Expect = 1e-13
Identities = 151/692 (21%), Positives = 286/692 (41%), Gaps = 146/692 (21%)
Query: 199 ENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIK 258
E L DI K EEL++ D +V L E +T+ D + + + DK++ ++
Sbjct: 334 ERLHDI-EFYKARVEELKE--DNQVLL--ETKTMLED-------QLEGTRARSDKLHELE 381
Query: 259 EENL-------DGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSK-SE 310
+ENL D + D+ K+I EL L ++ +H + +++S+ SE
Sbjct: 382 KENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSE 441
Query: 311 MHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSI 370
+ + ++ +T + L+ ++ L +T E++
Sbjct: 442 LSEAPQKSLGHEVNELTSSRLLKLEMENQS-------LTKTVEELR-------------- 480
Query: 371 ISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENL-------NLKSKMK 423
+ V+SV E +KI ++ KE+ ++ KKV LE+E + N ++ K
Sbjct: 481 -------TTVDSV-EGNASKILKME---KENQRLSKKVEILENEIVQEKQSLQNCQNLSK 529
Query: 424 PLIFTTQSLIQKVETY----EKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYN 479
L+ L + +ET E+Q+K L +E + +S + S+ + K I K N
Sbjct: 530 DLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKEN 589
Query: 480 -VLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMK 538
+L K K ++ EK+Q+ + L+ K K + + + NE + + E E ++
Sbjct: 590 KILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEE----LENELHHLEKENELLQ 645
Query: 539 ---TNILLIQDEKEMLE-------------KKT-----------HQLLKEKSSLGNE--- 568
TN+ + ++ E LE KKT L KE S L E
Sbjct: 646 KKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLE 705
Query: 569 -------LKESQLEIIQLKEKERLAKTEQETLLQIIETVKD-----------------EK 604
LK + +++ QL+ + + ++E+E L + +E +K E
Sbjct: 706 LRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIEN 765
Query: 605 LNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKEC 664
L+ TL+ S Q +E E+++++ T ++N L+E+K + + + +E
Sbjct: 766 QRLQKTLENSNKKIQQLESELQDLEMENQTLQKN-LEELKISSKRLEQLEKENKSLEQET 824
Query: 665 EMLSKMVMETKTDNQILKE--ELKKHSQE--NIKFEN----SISRLTEDKILLENYVRSI 716
L K + + +N+ L++ E+K + E N+K N + + E I E+ VR
Sbjct: 825 SQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLK 884
Query: 717 ENERDTLEFEMR---------HLQREYLSLSDKICNQHNDPSKTTYISRREKFHFDNYTH 767
E E++ E R L+ + +S K +ND K T+ + + + H
Sbjct: 885 ELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLH 944
Query: 768 EDTSSPQSR------PLASDLKGYFKVKDRTL 793
++ S+ SR L S LK ++K+ +
Sbjct: 945 DEQSTDDSRYKLLESKLESTLKKSLEIKEEKI 976
Score = 70.1 bits (170), Expect = 8e-12
Identities = 95/412 (23%), Positives = 185/412 (44%), Gaps = 65/412 (15%)
Query: 378 SKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVE 437
+K+ + ++ K + L + +E Q++ ++ L+ EN+NL S + L +
Sbjct: 258 AKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDEL-DALR 316
Query: 438 TYEKQLKNLVEEKSTIQSKLSKTEEYSK--ECLKEFKKIISKYNVLQGQNKTLEEKNIQL 495
++ L E S + +L E Y E LKE +++ + KT+ E ++
Sbjct: 317 EKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLL-------ETKTMLEDQLEG 369
Query: 496 SLEKQQMMEALD----QLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEML 551
+ + + L+ QLK+K H + + + +R IE E M+ N+ L +K+ +
Sbjct: 370 TRARSDKLHELEKENLQLKAKLHDME-----MERDMDRKKIE-ELMEENMTLEMAQKQSM 423
Query: 552 EKKTH------QLLK-------EKSSLG---NELKESQLEIIQLKEKERLAKTEQE--TL 593
++ H Q+ + + SLG NEL S+L +++ E + L KT +E T
Sbjct: 424 DESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEM-ENQSLTKTVEELRTT 482
Query: 594 LQIIETVKDEKLNLETTLQESTAARQIMEREI----ENIQTYQS---------------- 633
+ +E + L +E Q + +I+E EI +++Q Q+
Sbjct: 483 VDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTI 542
Query: 634 -TAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSK-MVMETKTDNQILKEELKKHSQE 691
T EN ++IK + E ++S + + ++ ++ V + + +N+IL E +K+ S +
Sbjct: 543 ETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSK 602
Query: 692 NIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICN 743
K E ++ ++ LE+Y E + LE E+ HL++E L KI N
Sbjct: 603 LSKIEFEKRQIKKE---LEHYKEKGERAEE-LENELHHLEKENELLQKKITN 650
Score = 41.6 bits (96), Expect = 0.003
Identities = 55/207 (26%), Positives = 89/207 (42%), Gaps = 21/207 (10%)
Query: 530 MSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGN---ELKESQLEIIQLKEKERLA 586
+S+E+ K I ++ E LE+KT QLL K L ELK Q E + L R A
Sbjct: 249 LSVELADAKAKIRRLRQE---LEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSA 305
Query: 587 KTEQETLLQIIE-TVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKN 645
+ ++ L + E V+ +KL ES +R + + +I+ Y++ EE L+E
Sbjct: 306 RMYRDELDALREKAVRVDKL-------ESEVSR--YKERLHDIEFYKARVEE--LKEDNQ 354
Query: 646 AKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTED 705
E K L + + S + E + +N LK +L E I L E+
Sbjct: 355 VLLET---KTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEE 411
Query: 706 KILLENYVRSIENERDTLEFEMRHLQR 732
+ LE + +E L +E+ + R
Sbjct: 412 NMTLEMAQKQSMDESLHLGWELEQISR 438
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 94.0 bits (232), Expect = 5e-19
Identities = 168/792 (21%), Positives = 334/792 (42%), Gaps = 110/792 (13%)
Query: 24 LNSSEGVKESGCSDTE-YGCIAESENQIQPQSALKVLQQQ-LES-FQALRMQ----TLQN 76
+N + ES CS+++ + ++ ++I+ A K+L Q+ +ES +LR L
Sbjct: 455 INLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDY 514
Query: 77 VSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLR 136
+ TE +E L +++ + ++ + L E K D L ++ + + +
Sbjct: 515 EQLRTEKEEMELKLKEKNDLDEFEAL---ERKTKKDQEMQLIHEISNLKNLVKHAEVYNQ 571
Query: 137 TSTDNLSSNIIIHPSENSDILKNYNNF--------------YRFLPTAPPNVMSQ----A 178
+ LSS + + E D +K + Y P M Q A
Sbjct: 572 DLENELSSKVELL-REKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDA 630
Query: 179 DTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDV 238
+TV LD + + FL+ ENL+ +KE++++ + N++Q Q+ +
Sbjct: 631 ETVALDAKRESA-FLRS---ENLE--------LKEKMKELATTYKQMENDIQLYQSQLEA 678
Query: 239 HRNGKYDMSPIHQDKMNFIKEEN--LDGNLNEDIK----------------SKRISELEA 280
+ + D+ Q N I + +DG + +D+ +K + E EA
Sbjct: 679 KKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEA 738
Query: 281 LVKKLLPFRETVS-KFHVHFCRKCKKLSKSEMHR-GKKNEKNNKEIPITGKNITDLKFHS 338
L ++++ E S V RK + E+H + +K E+ + L
Sbjct: 739 LREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEI 798
Query: 339 RVPRYTLSFLDQTKHEMKDKERQPFLV-------KQGSIISENEKTSKVNSVTEQCVAKI 391
+ L+ Q+ ++ D+E Q F K ++ ENE+ ++ + K
Sbjct: 799 GKTKDDLA-TTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKF 857
Query: 392 QYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKS 451
LK ++ K EL+ + ++ ++ + + L +++E + L+ + EK+
Sbjct: 858 DSSLGALK--TELSYKTQELQEKTREVQERLNEM----EQLKEQLENRDSTLQTVEREKT 911
Query: 452 TIQSKLSKTEEYSKECLKE---FKKIISKYNVLQGQNKTLEEKNIQLSLEKQ-QMMEALD 507
I KL +T E K +E K++ + + Q K+ + ++++ Q Q+ AL+
Sbjct: 912 LITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALE 971
Query: 508 QLKSKEHKTQSDMAIVNNENNR-MSIEMEAMKTNILLIQ-----DEKEMLEKKTHQLLKE 561
LK + + + ++ E +R + +E +T Q D+K+ LE K Q L
Sbjct: 972 SLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTA 1031
Query: 562 KSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIM 621
NE+ E Q +I L + E+ L Q++E+V EK L+T L+E+ +
Sbjct: 1032 DVK-DNEIIEQQRKIFSLIQ-------EKNELQQMLESVIAEKEQLKTDLKEN------I 1077
Query: 622 EREIENIQTYQSTAEE-NFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQI 680
E IEN + + +E QEI + +I K E+ + C+ L+++ + K +Q
Sbjct: 1078 EMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEG--ELSRTCDRLAEVEEKLKEKSQQ 1135
Query: 681 LKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDK 740
L+E+ Q+ + + +S + + KI N + +++NE E + H++ E L L+ K
Sbjct: 1136 LQEK----QQQLLNVQEEMSEM-QKKI---NEIENLKNELKNKELTLEHMETERLELAQK 1187
Query: 741 ICNQHNDPSKTT 752
+ + + T
Sbjct: 1188 LNENYEEVKSIT 1199
Score = 89.7 bits (221), Expect = 9e-18
Identities = 153/715 (21%), Positives = 295/715 (41%), Gaps = 104/715 (14%)
Query: 45 ESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHS 104
E +N + AL+V QL+ + +R +TL + QE++L+M++ +D++T
Sbjct: 1350 ERDNLKTIKEALEVKHDQLK--EHIR-ETLAKIQESQSKQEQSLNMKE----KDNETTKI 1402
Query: 105 VEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTD--NLSSNIIIHPSENSDILKNYNN 162
V E Q +D+ LR + LS + E + K ++
Sbjct: 1403 VSEM----------------EQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDD 1446
Query: 163 FYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHS-IKQMKEELQKSHDG 221
R + S++D + K I KH E + H +K+ +E + +
Sbjct: 1447 LQRLQEV----LQSESDQL---KENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVN 1499
Query: 222 EVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEAL 281
E+ T+Q + N K Q+K+ I E+ E K+ISE++
Sbjct: 1500 LSEKETEISTIQKQLEAI-NDKL------QNKIQEIYEKE------EQFNIKQISEVQEK 1546
Query: 282 VKKLLPFRETVSKFHVHFCRKCK-----KLSKSEMHRGKKNEKNNKEIPITGKNITDLKF 336
V +L F+E RK K + + + +++ +EI I K ++K
Sbjct: 1547 VNELKQFKEH---------RKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMK- 1596
Query: 337 HSRVPRYTLSFLDQTKHEMKD--------KERQPFLVKQGSIISENEKTSKVNSVTEQCV 388
RV DQ K K+ +E++ +K ++ EK ++ + EQ
Sbjct: 1597 --RVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFE 1654
Query: 389 AKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVE 448
+ L+N E++++ + + E E ++ + L ++L KVE QLK +
Sbjct: 1655 TQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETL--KVE--RDQLKENLR 1710
Query: 449 EKSTIQSKLSKTEEYS--KECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEAL 506
E TI L K EE LKE ++ I K + + KT E N+Q LE
Sbjct: 1711 E--TITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSE-KTNEISNMQKDLEHSN----- 1762
Query: 507 DQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLG 566
D LK+++ K Q ++ I + ++ ++ + D+ ++K +
Sbjct: 1763 DALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKI 1822
Query: 567 NELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIE 626
ELK ++ ++I LK+ + + + Q+ + +KD+ L L + EIE
Sbjct: 1823 QELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLS-------------KLEIE 1869
Query: 627 NIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELK 686
N+ Q E L+E+K+ E + + E + L + + ETK + +++ELK
Sbjct: 1870 NLNLAQKLHEN--LEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELK 1927
Query: 687 KHSQENIKFENSISRL----TEDKILLENYVRSIENERDTLEFEMRHLQREYLSL 737
+ + + ++ +L +E I + + + ++ +D L+ +++ LQ++ L L
Sbjct: 1928 TARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQL 1982
Score = 86.3 bits (212), Expect = 1e-16
Identities = 164/752 (21%), Positives = 311/752 (41%), Gaps = 108/752 (14%)
Query: 59 LQQQLESFQA----LRMQTLQNVSMPTENQEEN-------------LSMEKSHHF----E 97
LQQ LES A L+ +N+ M ENQEE ++ EK+H E
Sbjct: 1055 LQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGE 1114
Query: 98 DSKT---LHSVEEKLSGDSVN---SLPQSVNVPSQIHS-----EDTLTLRTSTDNLSSNI 146
S+T L VEEKL S Q +NV ++ + L+ N +
Sbjct: 1115 LSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTL 1174
Query: 147 IIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICH 206
+E ++ + N Y + + + K + + L+ F D +
Sbjct: 1175 EHMETERLELAQKLNENYEEVKS-------------ITKERKVLKELQKSFETERDHLRG 1221
Query: 207 SIKQMKEE-LQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGN 265
I++++ LQ + ++A + + +T ++ R+ + I +N E
Sbjct: 1222 YIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQI----INTQDLEKSHTK 1277
Query: 266 LNEDIKS-KRISELEALVKKLLPFRETVSKFHVHFCRKCKK----LSKSEMHRGKKNEK- 319
L E+I EL VK++ +ET+++ + + K L++ EM R + NEK
Sbjct: 1278 LQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKF 1337
Query: 320 --NNKEIPITGKNITDLKF--------HSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGS 369
+ +EI K +LK H ++ + L + + E + K+ Q +K+
Sbjct: 1338 QESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQ-ESQSKQEQSLNMKEKD 1396
Query: 370 -----IISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVME-----------LES 413
I+SE E+ +S + ++ L L+ES K V + L+S
Sbjct: 1397 NETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQS 1456
Query: 414 ENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKK 473
E+ LK +K ++ ++++ LK E + ++ LS+ E K+ +
Sbjct: 1457 ESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEA 1516
Query: 474 IISKY-NVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSI 532
I K N +Q + E+ NI+ E Q+ + L Q KEH+ D A+ + E+ + +
Sbjct: 1517 INDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQF--KEHRKAKDSALQSIESKMLEL 1574
Query: 533 --EMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKE-----RL 585
++ + I ++ EKE +++ L E+ L KE ++ + +EKE
Sbjct: 1575 TNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMT 1634
Query: 586 AKTEQETLLQIIETVKD----EKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQ 641
A E + + IE +K+ +KLNLE E+ QI+ EN++ +S +E
Sbjct: 1635 AVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILH---ENLEEMRSVTKER--D 1689
Query: 642 EIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISR 701
++++ + + ++ L E +E +E + + +I+ LK+H + K +S
Sbjct: 1690 DLRSVEETLKVERDQLKENLRETITRD---LEKQEELKIVHMHLKEHQETIDKLRGIVSE 1746
Query: 702 LTEDKILLENYVRSIENERDTLEFEMRHLQRE 733
T + + N + +E+ D L+ + +Q E
Sbjct: 1747 KTNE---ISNMQKDLEHSNDALKAQDLKIQEE 1775
Score = 77.8 bits (190), Expect = 4e-14
Identities = 152/742 (20%), Positives = 304/742 (40%), Gaps = 116/742 (15%)
Query: 53 QSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGD 112
QS K Q+ ++F+ L M Q M E + E ++ E + ++++ S
Sbjct: 809 QSNYKSTDQEFQNFKTLHMDFEQKYKMVLE-ENERMNQEIVNLSKEAQKFDS-------- 859
Query: 113 SVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPP 172
S+ +L ++ +Q E T ++ + + + EN D +
Sbjct: 860 SLGALKTELSYKTQELQEKTREVQERLNEMEQ--LKEQLENRD--------------STL 903
Query: 173 NVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTL 232
+ + T+I +K + T+ +K + DD+ KQ++E LQ D + ++ +
Sbjct: 904 QTVEREKTLITEKLQQTLEEVKT-LTQEKDDL----KQLQESLQIERDQLKSDIHDTVNM 958
Query: 233 QTDPDVHRNGKYDMSPIHQDKMNFIKE---ENLDGNLN---------------------- 267
D + HQ+ +N +K E + NL+
Sbjct: 959 NIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKK 1018
Query: 268 EDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNN------ 321
+D+++K L A VK E + + F +K +M EK
Sbjct: 1019 QDLEAKNTQTLTADVKD----NEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLK 1074
Query: 322 KEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVN 381
+ I +T +N +L+ + + Q K+ KE + L + ++E E+ K+
Sbjct: 1075 ENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGE--LSRTCDRLAEVEE--KLK 1130
Query: 382 SVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSL-IQKVETYE 440
++Q K Q L N +E ++QKK+ E+E NLK+++K T + + +++E +
Sbjct: 1131 EKSQQLQEKQQQLLNVQEEMSEMQKKINEIE----NLKNELKNKELTLEHMETERLELAQ 1186
Query: 441 KQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQ 500
K +N E KS ++K + KE K F+ ++ + L+G + +E +Q E +
Sbjct: 1187 KLNENYEEVKS-----ITKERKVLKELQKSFE---TERDHLRGYIREIEATGLQTKEELK 1238
Query: 501 QMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLK 560
+ + KEH+ D E R E A N ++ L+++ L +
Sbjct: 1239 -----IAHIHLKEHQETID------ELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHE 1287
Query: 561 EKSSLGN--ELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAAR 618
E+ L N E+ E+Q + +L+ + T+ T L IE E+L L QES
Sbjct: 1288 EQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEM---ERLRLNEKFQESQEEI 1344
Query: 619 QIMEREIENIQTYQSTAE----------ENFLQEIKNAKSEASIYKNSLSEIGKECEMLS 668
+ + +E +N++T + E L +I+ ++S+ N + + +++S
Sbjct: 1345 KSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVS 1404
Query: 669 KMVMETKTDNQILKEE-----LKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTL 723
+M D+ +L+ E L K QE+ S+++ +D L+ +++E D L
Sbjct: 1405 EMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDD---LQRLQEVLQSESDQL 1461
Query: 724 EFEMRHLQREYLSLSDKICNQH 745
+ ++ + ++L +++ H
Sbjct: 1462 KENIKEIVAKHLETEEELKVAH 1483
Score = 75.1 bits (183), Expect = 2e-13
Identities = 140/639 (21%), Positives = 284/639 (44%), Gaps = 104/639 (16%)
Query: 208 IKQMKEEL--QKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMN---FIKEENL 262
IK+++E + QK + ++ L+ L++++ DP + +D + D F++ ENL
Sbjct: 591 IKKLQEYIDSQKLENIKMDLSYSLESIE-DPKQMKQTLFDAETVALDAKRESAFLRSENL 649
Query: 263 DGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKN-N 321
+ L E +K EL K++ +L +S++ KK + +
Sbjct: 650 E--LKEKMK-----ELATTYKQM---------------ENDIQLYQSQLEAKKKMQVDLE 687
Query: 322 KEIPITGKNITDLK--FHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSK 379
KE+ IT L +VP+ L L+ E K + Q L K+ + ENE
Sbjct: 688 KELQSAFNEITKLTSLIDGKVPKDLLCNLEL---EGKITDLQKELNKE---VEENE---- 737
Query: 380 VNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETY 439
+ V + L++ E +++K++ + +SE L++ + K +F+ +V
Sbjct: 738 ---ALREEVILLSELKSLPSEVERLRKEIQD-KSEELHIITSEKDKLFS------EVVHK 787
Query: 440 EKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIIS-------KYNVLQGQNKTLEEKN 492
E +++ L+EE + L+ T+ K +EF+ + KY ++ +N+ + ++
Sbjct: 788 ESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEI 847
Query: 493 IQLSLEKQQMMEALDQLKSK-EHKTQS------DMAIVNNENNRMSIEMEAMKTNILLIQ 545
+ LS E Q+ +L LK++ +KTQ ++ NE ++ ++E + + ++
Sbjct: 848 VNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVE 907
Query: 546 DEKEMLEKKTHQLLKEKSSLGNE---LKESQLEIIQLKEKERLAKTEQETLLQIIETVKD 602
EK ++ +K Q L+E +L E LK+ Q E +Q+ E+++L +T+ I+T +
Sbjct: 908 REKTLITEKLQQTLEEVKTLTQEKDDLKQLQ-ESLQI-ERDQLKSDIHDTVNMNIDTQEQ 965
Query: 603 EKLNLETTLQE----STAARQIMEREIENIQTYQSTAE--ENFLQ-----------EIKN 645
+ LE+ Q +T +I E N+ ++T E + F Q E KN
Sbjct: 966 LRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKN 1025
Query: 646 AKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQIL------KEELKKHSQENIKFENSI 699
++ + K+ +EI ++ + ++ E Q+L KE+LK +ENI E +I
Sbjct: 1026 TQTLTADVKD--NEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENI--EMTI 1081
Query: 700 SRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLS---DKICNQHNDPSKTTYISR 756
E ++L + ++ +++ + E H ++ LS D++ + + +
Sbjct: 1082 ENQEELRLLGD----ELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQ 1137
Query: 757 REKFHFDNYTHEDTSSPQSRPLASDLKGYFKVKDRTLKH 795
++ N E + + +LK K K+ TL+H
Sbjct: 1138 EKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEH 1176
Score = 60.8 bits (146), Expect = 5e-09
Identities = 117/623 (18%), Positives = 247/623 (39%), Gaps = 92/623 (14%)
Query: 210 QMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNED 269
Q+KE LQ++ ++ + EL+T + H+ + +K I + D + ++D
Sbjct: 1907 QLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKD 1966
Query: 270 IKSKRISELEALVKKLLPFRETVSKFH--VHFCRKCKKLSKSE-----------MHRGKK 316
K+I EL+ +LL +E V+ H ++ + KK +++ KK
Sbjct: 1967 ELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKK 2026
Query: 317 NEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEK 376
++ +EI I K +L+ + T EM ++RQ VK + + +
Sbjct: 2027 LHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQ 2086
Query: 377 TSKVNSVTEQCVAKIQYLQNY----------------LKESVQIQKKVMELESENLNLKS 420
S+ E+C + L+ Y L++ ++ QK++ NL+L
Sbjct: 2087 QHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPY 2146
Query: 421 KMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEF--------- 471
I + L + + ++++ + S ++K +E E + +F
Sbjct: 2147 LQTKHI---EKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVE 2203
Query: 472 --KKIISKYNVLQ---------------GQNKTLEEKNI----------QLSLEKQQMM- 503
K+++ K LQ QN L + I + E QQ++
Sbjct: 2204 KQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLS 2263
Query: 504 --EALDQLKSKEHKTQSDMAIVNN----ENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQ 557
+ + Q + T+ D+ + N EN+R+ I+ I +E E+++
Sbjct: 2264 NRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSAT 2323
Query: 558 LLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAA 617
+ KE LKE ++ + + KT + Q+ T +D K T+
Sbjct: 2324 ISKEWEQDLKSLKEKNEKLFK---NYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTT 2380
Query: 618 RQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTD 677
+I RE+EN + + +I + E + + ++++ + +K + +TK
Sbjct: 2381 EKI--RELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKET 2438
Query: 678 NQILKEEL----KKHSQENIKFENSISRLTEDKIL-LENYVRSIENERDTLEF--EMRHL 730
Q+L++++ K + +E + + ++ +K+ + + + I + T+E+ E+ L
Sbjct: 2439 IQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRL 2498
Query: 731 QREYLSLSDK-----ICNQHNDP 748
RE L S + + ++H DP
Sbjct: 2499 LRENLRRSQQAQDTSVISEHTDP 2521
Score = 54.7 bits (130), Expect = 3e-07
Identities = 149/787 (18%), Positives = 325/787 (41%), Gaps = 128/787 (16%)
Query: 1 MSPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQ 60
+S +Q +++ + S+ LS +I N + K + + E +N + + LK+ +
Sbjct: 1846 VSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLER 1905
Query: 61 QQL-ESFQALR------MQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDS 113
QL ES Q + Q L+ M ++ +E + + E + + +++ L S
Sbjct: 1906 DQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLD-KS 1964
Query: 114 VNSLPQSVNVPSQIHSEDTLTLRTSTD-NLSSNIIIHPSENSDILKNYNNFYRFLPTAPP 172
+ L + + ++ ++ LR D N+S I +E + K +
Sbjct: 1965 KDELQKKIQ---ELQKKELQLLRVKEDVNMSHKKI---NEMEQLKKQFE---------AQ 2009
Query: 173 NVMSQADTVILDKSKITVPFLKHGFCENLDDICHS---IKQMKEELQKSHDGEVALTNEL 229
N+ Q+ V +D ++T H E + + ++++KE L+ D +A E+
Sbjct: 2010 NLSMQS--VRMDNFQLTKKL--HESLEEIRIVAKERDELRRIKESLKMERDQFIATLREM 2065
Query: 230 -----QTLQTDPDVH--RNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALV 282
Q Q P+ +G+ ++ ++K + IKE KR SE++
Sbjct: 2066 IARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKE-----------LLKRYSEMDDHY 2114
Query: 283 KKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPR 342
+ L + K + F ++ K+ + K+ +++ T ++FH + +
Sbjct: 2115 ECLNRLSLDLEK-EIEFQKELSMRVKANLSLPYLQTKHIEKL-FTANQRCSMEFHRIMKK 2172
Query: 343 --YTLSFLDQTK---HEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNY 397
Y LS++ + K HE +K F+ + + E K+ + + C + L++
Sbjct: 2173 LKYVLSYVTKIKEEQHESINKFEMDFI---DEVEKQKELLIKIQHLQQDCDVPSRELRD- 2228
Query: 398 LKESVQIQKKVMEL-----ESENLNLKSKMKPLIFTTQSLIQKVETYE------KQLKNL 446
LK + + + E+ ESE ++K++ + ++ + + Q +E + ++LKN
Sbjct: 2229 LKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNG 2288
Query: 447 VEEKS---------------TIQSKLSKTEEYSKECLKEFK-----------KIISKYNV 480
+++++ I ++ ++ EE S KE++ K+ Y
Sbjct: 2289 IQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQT 2348
Query: 481 L--------QGQNKTLEEKNIQLSLEKQQMM-EALDQLKSKEHKTQSDMAIVNNENNRMS 531
L Q T + KN ++ Q+ E + +L++ H+ + ++ +M
Sbjct: 2349 LKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQ 2408
Query: 532 IEMEAMKTNILLIQ----DEKEMLEK--KTHQLLKEKSSLGNELKESQLEIIQLK----- 580
E+E I +Q + + LEK +T Q+L++K +LG + + ++E +++K
Sbjct: 2409 KELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKID 2468
Query: 581 -EKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEE-- 637
EK + AK ++ + TV+ +K + + ++Q + + + T + +
Sbjct: 2469 LEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPL 2528
Query: 638 ------NFLQEIKNA--KSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHS 689
+Q K KSE + +S++ ++ E L K E ++NQ L E+K
Sbjct: 2529 TCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWK 2588
Query: 690 QENIKFE 696
+ +K E
Sbjct: 2589 ERTLKRE 2595
Score = 36.2 bits (82), Expect = 0.12
Identities = 49/209 (23%), Positives = 91/209 (43%), Gaps = 26/209 (12%)
Query: 569 LKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENI 628
LK + EI+ LK++ L + ET Q +E KD+ L L+E +++ +IEN+
Sbjct: 345 LKRYRKEIMDLKKQ--LEEVSLETRAQAME--KDQLAQL---LEEKDLLQKVQNEKIENL 397
Query: 629 QTYQSTAEENFLQEIKNAKSE-------ASIYKNSLSEIGKECEMLSKMVMET-KTDNQI 680
T+ LQ+ AK + I K S + + + + +T K +
Sbjct: 398 TRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINL 457
Query: 681 LKEELKKHSQENIKFENSISRLTE------DKIL----LENYVRSIENERDTLEFEMRHL 730
L+E + E+ F N++ L+E K+L +E+ + S+ + D L + L
Sbjct: 458 LREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQL 517
Query: 731 QREYLSLSDKICNQHNDPSKTTYISRREK 759
+ E + K+ + ND + + R+ K
Sbjct: 518 RTEKEEMELKL-KEKNDLDEFEALERKTK 545
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 93.2 bits (230), Expect = 8e-19
Identities = 184/845 (21%), Positives = 351/845 (41%), Gaps = 152/845 (17%)
Query: 1 MSPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGC-IAESENQIQPQSAL--- 56
+S EK +E +V + L S++ E +KE + TE + +++ Q Q Q AL
Sbjct: 443 LSSEKLMDKEQQVADLQLKLSRL---EEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQS 499
Query: 57 ---KVLQQQLESFQALRM-----QTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEK 108
K+ + Q + Q LR Q +QN+ + +EN+S+ + ++ + L++ +
Sbjct: 500 TTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLE----KEREDLYAKIQA 555
Query: 109 LSGDS--VNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRF 166
G++ +N L + + + ++ T L+ +++ H ++
Sbjct: 556 GEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSES-------HKQAQENLHDQVQEQKAH 608
Query: 167 LPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALT 226
L A V+S +V S++ E+ + + Q+K + + E A T
Sbjct: 609 LRAAQDRVLSLETSVNELNSQLN---------ESKEKVSQLDIQIKAKTELLLSAEAAKT 659
Query: 227 NELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLL 286
+ LQ D +N D K++ L+ K ++L+ + KL
Sbjct: 660 AQRADLQNHLDTAQNALQD------------KQQELN---------KITTQLDQVTAKLQ 698
Query: 287 PFRETVSKFHVHFCR-KCKKLS---KSEMHRG--KKNEKNNKEIPITGKN-ITDLKFHSR 339
+E S+ H K K LS K+E G KK E ++ E+ + + + DL+ +
Sbjct: 699 DKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQ 758
Query: 340 VPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISEN----EKTSKVNSVTEQCVAKIQYLQ 395
+ T E++ E L + I+S +K S+ +Q + K + +
Sbjct: 759 L---------NTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEK 809
Query: 396 NYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQS 455
LK+ + + +++ E LN + I TT + +QKV+ EK+ L+ E ST++
Sbjct: 810 QILKQDFETLSQETKIQHEELNNR------IQTTVTELQKVKM-EKEA--LMTELSTVKD 860
Query: 456 KLSKTEEYSKECLKEFKKIISKYNV-----------------LQGQNKTLEEKNIQLSLE 498
KLSK + K EF+K K +Q +N E+K ++ SLE
Sbjct: 861 KLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLE 920
Query: 499 KQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQL 558
K++ EA QLK + + Q + N + E + ++ NI ++ E +K+ L
Sbjct: 921 KEK--EASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEAL 978
Query: 559 LKE-------KSSLGNELKESQLEIIQ--LKEKERLA------KTEQETLLQIIETVKDE 603
E K+ L N+L++ + Q EKE+++ + QET Q+
Sbjct: 979 QGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGR 1038
Query: 604 KLNLETTLQESTAARQIMEREIENIQTYQSTA--EENFLQEIKNAKS---------EASI 652
+ L T Q+ + + + E++ + ++ + +QE+K AK+ E +
Sbjct: 1039 ESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQL 1098
Query: 653 YKN--SLSEIGKECEMLSKMVMETKT------------DNQILK--EELKKHSQENIKFE 696
+ +L +I KE + K ++ K+ + +I K EELK H E+IK
Sbjct: 1099 QERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIK-- 1156
Query: 697 NSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISR 756
I+ L + K LL ++ + D+L+ + +R L D++ + + K +I +
Sbjct: 1157 -EITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQV-KKEEEELKKEFIEK 1214
Query: 757 REKFH 761
K H
Sbjct: 1215 EAKLH 1219
Score = 85.5 bits (210), Expect = 2e-16
Identities = 153/694 (22%), Positives = 288/694 (41%), Gaps = 101/694 (14%)
Query: 12 EVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQQLESFQALRM 71
E DS+ + ASK E D + ++ +++ K L+ + E + R+
Sbjct: 736 EADSLEVKASK---------EQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRL 786
Query: 72 ------QTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPS 125
+ L+++ QEE + K +D +TL S E K+ + +N+ Q+
Sbjct: 787 DLQKKSEALESIKQKLTKQEEEKQILK----QDFETL-SQETKIQHEELNNRIQTTVTEL 841
Query: 126 QIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDK 185
Q + L T + + S+ SD LKN + + + ILD
Sbjct: 842 QKVKMEKEALMTELSTVKDKL----SKVSDSLKNSKSEFE-------KENQKGKAAILDL 890
Query: 186 SKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYD 245
K T LKH +++ K++K+ L+K + L EL ++Q +N
Sbjct: 891 EK-TCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTL-- 947
Query: 246 MSPIHQDKMNFIKEENLDGNLNE-----DIKSKRISELEALVK-KLLPFRETVSKFHVHF 299
K N +E+ L GN+NE + K K+I L+ +K +L E +K
Sbjct: 948 -------KQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQL 1000
Query: 300 CRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKE 359
+ ++L+ +E + + N ++ T K + F+ R S L T+ ++K E
Sbjct: 1001 TQAAQELA-AEKEKISVLQNNYEKSQETFKQLQS-DFYGRE-----SELLATRQDLKSVE 1053
Query: 360 RQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLK 419
+ L ++ I + N+ ++ + E AK Q+ K+ Q+Q++ L+
Sbjct: 1054 EKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQD------ 1107
Query: 420 SKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYN 479
IQK ++ ++ K LV EKS KL++ EE +C +E K I+K N
Sbjct: 1108 -------------IQKEKSLKE--KELVNEKS----KLAEIEEI--KCRQE--KEITKLN 1144
Query: 480 VLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKT 539
+K K I + +Q++ + Q + K S A V E I + +K
Sbjct: 1145 EELKSHKLESIKEITNLKDAKQLL--IQQKLELQGKADSLKAAVEQEKRNQQILKDQVKK 1202
Query: 540 NILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIET 599
E+E L+K + +++++ L +E+KE ++ + + +E E + L + + T
Sbjct: 1203 -------EEEELKK---EFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGT 1252
Query: 600 VKDEKLNLETTLQESTAARQIMEREIENIQ-TYQSTAEEN--FLQEIKNAKSEASIYKNS 656
VK E + + + E + EI ++ T Q+ +E L+ + E +
Sbjct: 1253 VKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTK 1312
Query: 657 LSEIGKECEMLSKMVMETKTDNQILKEELKKHSQ 690
+ E+ ++ + + V E +NQ L+ KH+Q
Sbjct: 1313 VLELQRKLDNTTAAVQELGRENQSLQ---IKHTQ 1343
Score = 68.6 bits (166), Expect = 2e-11
Identities = 74/355 (20%), Positives = 156/355 (43%), Gaps = 25/355 (7%)
Query: 390 KIQYLQNYLKESVQIQKKVM-ELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVE 448
++Q LQ LKE +++ ELE + + KP T S + +++ E+QL+
Sbjct: 91 EVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAE-LQSLEQQLEEAQT 149
Query: 449 EKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQ 508
E I+ E+ + + E I SKY+ + + E+K +L+ E + +
Sbjct: 150 ENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQD 209
Query: 509 LKSK--EHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLG 566
LK++ + D+A++ E ++++ + N+ L + E+++ +L E L
Sbjct: 210 LKTELLQRPGIEDVAVLKKE----LVQVQTLMDNMTLER------ERESEKLKDECKKLQ 259
Query: 567 NELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIE 626
++ S+ I QL+ + LAK QE + + E K + E T + T ++++E
Sbjct: 260 SQYASSEATISQLRSE--LAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKE-- 315
Query: 627 NIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELK 686
Q Y E++ + + +A++++ L +C+ L + ++T + EL
Sbjct: 316 --QDYTKLEEKHNEESVSKKNIQATLHQKDL-----DCQQLQSRLSASETSLHRIHVELS 368
Query: 687 KHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKI 741
+ + K + +S + L+ + ++ +R+ E LQ E L K+
Sbjct: 369 EKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKL 423
Score = 67.4 bits (163), Expect = 5e-11
Identities = 142/770 (18%), Positives = 313/770 (40%), Gaps = 103/770 (13%)
Query: 59 LQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKT----LHSVEEKLSGDSV 114
L+++LE +Q L+ Q + + T++ E S+E+ E+++T + +++ +
Sbjct: 109 LKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQ--QLEEAQTENFNIKQMKDLFEQKAA 166
Query: 115 NSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNV 174
+ ++ S+ E +LR + + + + ++ + ++++ P
Sbjct: 167 QLATEIADIKSKYDEE--RSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVA 224
Query: 175 MSQADTVILDKSKITVPFLKHGFCENLDDICH-----------SIKQMKEELQKSHDGEV 223
+ + + V + + + E L D C +I Q++ EL K
Sbjct: 225 VLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVA 284
Query: 224 ALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEE----NLDGNLNEDIKSK------ 273
ELQ L++ + ++ N +K+E L+ NE+ SK
Sbjct: 285 VYVQELQKLKSSVNELTQKNQTLTE------NLLKKEQDYTKLEEKHNEESVSKKNIQAT 338
Query: 274 ---RISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKN 330
+ + + L +L ++ + HV K + K + + E + + K
Sbjct: 339 LHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEV-ETKYQHLKAEFKQ 397
Query: 331 ITDLKFHSRVPRYTL-SFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVA 389
+ + L S ++Q ++ + ERQ G + + + +S+ EQ VA
Sbjct: 398 LQQQREEKEQHGLQLQSEINQLHSKLLETERQ-LGEAHGRLKEQRQLSSEKLMDKEQQVA 456
Query: 390 ----KIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKN 445
K+ L+ LKE V ++ + + + L +T + +++ + +Q+
Sbjct: 457 DLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLR 516
Query: 446 LVEEK----STIQSKLSKTEEYSKECLKEFKKIISK----------YNVLQGQNKTLEEK 491
+ +K +++ L K++E KE + + +K N LQ +N TL+E+
Sbjct: 517 QIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQ 576
Query: 492 NIQLS--LEKQ-------------QMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEA 536
QL+ L+ Q Q+ E L++ + + S VN N++++ E
Sbjct: 577 VTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEK 636
Query: 537 MKTNILLIQDEKEML----EKKTHQ---LLKEKSSLGNELKESQLEI----IQLKEKERL 585
+ + I+ + E+L KT Q L + N L++ Q E+ QL +
Sbjct: 637 VSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAK 696
Query: 586 AKTEQETLLQI---IETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQE 642
+ +QE Q+ ++ K++ L+LE +E QI + E ++++ ++E LQ+
Sbjct: 697 LQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEG--QIKKLEADSLEV--KASKEQALQD 752
Query: 643 IKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQ-------ILKEELKKHSQENIKF 695
++ + + + +E+ K+ EM ++V T+ D Q +K++L K +E
Sbjct: 753 LQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQIL 812
Query: 696 ENSISRLTEDKIL----LENYVRSIENERDTLEFEMRHLQREYLSLSDKI 741
+ L+++ + L N +++ E ++ E L E ++ DK+
Sbjct: 813 KQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKL 862
>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
[Homo sapiens]
Length = 1388
Score = 91.7 bits (226), Expect = 2e-18
Identities = 118/591 (19%), Positives = 255/591 (43%), Gaps = 94/591 (15%)
Query: 199 ENLDDICHSIKQMKEELQKSHDGEVALTNELQT----LQTDPDV--HRNGKYDMSPIHQD 252
E L+ C S+ E+ K + E+ L +++ L+ + + H+N +Y H+
Sbjct: 464 EELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEA 523
Query: 253 KMNFIKEENLDGNLN------EDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKL 306
K+ NL+ ++N ED+K KR + +K+ + + + + L
Sbjct: 524 D----KKRNLENDVNSLKDQLEDLK-KRNQNSQISTEKVNQLQRQLDETNA--------L 570
Query: 307 SKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVK 366
++E + K E + K I L+ ++R + L+ K +++ + F+
Sbjct: 571 LRTESDTAARLRKTQAE---SSKQIQQLESNNRDLQDKNCLLETAKLKLEKE----FINL 623
Query: 367 QGSIISENEKTSKVNSVTEQCVAKIQYLQNYLK-----------ESVQIQKKVMELESEN 415
Q ++ SE + + + +I L+ LK E Q+Q++ +LE E
Sbjct: 624 QSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEK 683
Query: 416 LNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKII 475
N++ M + Q +++ E K K + +K+ I + EE E +KE +K +
Sbjct: 684 SNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESI---EEAKSEAMKEMEKKL 740
Query: 476 SKYNVLQGQ--------------------------NKTLEEKNIQLSLEKQQMMEALDQL 509
+ L+ + N+ L++K++ L+ + + + ++Q
Sbjct: 741 LEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDV-LNEDVRNLTLKIEQE 799
Query: 510 KSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNEL 569
K TQ+D+ + + N + + + +K + + K LEK+ +L KE+ ++
Sbjct: 800 TQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQM 859
Query: 570 KESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQ 629
KE Q ++ E E+ T +T ++ ++ +EK L LQ+ ++E+++ +
Sbjct: 860 KELQDQL----EAEQYFSTLYKTQVRELKEECEEKTKLGKELQQK-------KQELQDER 908
Query: 630 TYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHS 689
+ E L + + + SI + S++ KE K++ E + +KE + +H
Sbjct: 909 DSLAAQLEITLTKADSEQLARSIAEEQYSDLEKE-----KIMKELE-----IKEMMARHK 958
Query: 690 QENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDK 740
QE + + +I+ L E L + V ++ NE++ L +++ +Q + L D+
Sbjct: 959 QELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDE 1009
Score = 60.5 bits (145), Expect = 6e-09
Identities = 148/770 (19%), Positives = 309/770 (40%), Gaps = 124/770 (16%)
Query: 5 KQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIA----------ESENQIQPQS 54
+++ E E+ L + + L++ KE + E C + E E +I +
Sbjct: 437 RKNEESQEIQKKLYTLEEHLSNEMQAKE----ELEQKCKSVNTRLEKTAKELEEEITLRK 492
Query: 55 ALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSV 114
+++ +QLE +AL LQ+ + + + ++ + +K + D +L E L +
Sbjct: 493 SVESALRQLEREKAL----LQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQ 548
Query: 115 NSL--PQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPP 172
NS + VN + E LRT +D ++ + +E+S ++ + R L
Sbjct: 549 NSQISTEKVNQLQRQLDETNALLRTESDT-AARLRKTQAESSKQIQQLESNNRDLQDK-- 605
Query: 173 NVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTL 232
N + + + L+K I NL S E ++H E+ + +
Sbjct: 606 NCLLETAKLKLEKEFI-----------NLQSALES-----ERRDRTHGSEIINDLQGRIC 649
Query: 233 QTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETV 292
+ D+ +NGK ++ + +K L + K K E++ + + +
Sbjct: 650 GLEEDL-KNGKILLAKVELEK------RQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLE 702
Query: 293 SKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTL------S 346
+ H K + K++++ + K+ + K + + +V L S
Sbjct: 703 QEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCS 762
Query: 347 FLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQ--- 403
LD + + K + L+KQ ++ NE + EQ K QN LK Q
Sbjct: 763 LLDCDLKQSQQKINE--LLKQKDVL--NEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVN 818
Query: 404 -IQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQ--SKLSKT 460
++ +L+ EN +L L L ++ + + Q+K L ++ Q S L KT
Sbjct: 819 TLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKT 878
Query: 461 E--EYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQS 518
+ E +EC ++ K K L++K +L E+ + L+ +K Q
Sbjct: 879 QVRELKEECEEKTKL-----------GKELQQKKQELQDERDSLAAQLEITLTKADSEQL 927
Query: 519 DMAIVNNENNRMSIE--MEAMKTNILLIQDEKEMLEKKTH----------------QLLK 560
+I + + + E M+ ++ ++ + ++E+ EK L
Sbjct: 928 ARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLAN 987
Query: 561 EKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQI 620
EK L N+LK+ Q ++ +LK++E A I+ +++L E TL+
Sbjct: 988 EKEELNNKLKDVQEQLSRLKDEEISAAA--------IKAQFEKQLLTERTLK-------- 1031
Query: 621 MEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQI 680
T N L EI N K + + + +++ ++ + K+ ME K++ +
Sbjct: 1032 -------------TQAVNKLAEIMNRKE--PVKRGNDTDVRRKEKENRKLHMELKSEREK 1076
Query: 681 LKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHL 730
L +++ K+ +E + + I+ ++ +I L+ + S +++ + L +++ L
Sbjct: 1077 LTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQAL 1126
Score = 31.2 bits (69), Expect = 4.0
Identities = 28/115 (24%), Positives = 52/115 (45%), Gaps = 4/115 (3%)
Query: 637 ENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQE-NIKF 695
EN L + E ++ +E +E + + E ++ KEEL++ + N +
Sbjct: 418 ENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRL 477
Query: 696 ENSISRLTEDKIL---LENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHND 747
E + L E+ L +E+ +R +E E+ L+ + QR+ +DK N ND
Sbjct: 478 EKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLEND 532
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 88.6 bits (218), Expect = 2e-17
Identities = 140/654 (21%), Positives = 268/654 (40%), Gaps = 88/654 (13%)
Query: 109 LSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLP 168
L S++S +S+ + + +ED L ++L S+ I +E + K Y L
Sbjct: 1560 LENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILL 1619
Query: 169 TAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNE 228
+ NV ++A E + + +++Q K+EL G++ T E
Sbjct: 1620 QSYENVSNEA--------------------ERIQHVVEAVRQEKQELY----GKLRST-E 1654
Query: 229 LQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPF 288
+T+ + + + +M + + F K K ++I ELE +L
Sbjct: 1655 ANKKETEKQL-QEAEQEMEEMKEKMRKFAKS-----------KQQKILELEEENDRL--- 1699
Query: 289 RETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFL 348
+ VH K + + K E KF S +S
Sbjct: 1700 -----RAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQS-----LMSEK 1749
Query: 349 DQTKHEMKDKERQ-PFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKK 407
D E++D + Q V + + + EK +VTE+ Q + +E +
Sbjct: 1750 DSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGT---QSIPGETEEQDSLSMS 1806
Query: 408 VMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKEC 467
SE++ P + S ++ Y +Q+ L E + ++ + K +E+S+
Sbjct: 1807 TRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTL 1866
Query: 468 LKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQL-----KSKEHKTQSDMAI 522
E ++S+ + G+ K L+E+ +++L QQ+ E L ++ ++E K + +
Sbjct: 1867 ENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERL 1926
Query: 523 VN-------NENNRMSIEMEAMKTNILLIQDEKEM------LEKKTHQLLKEKSSLGNEL 569
+N + N +A N LL + K + LE++ QL+KEK+ + +E+
Sbjct: 1927 MNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEI 1986
Query: 570 KESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLE---TTLQESTAARQIMEREIE 626
++ LE IQ +KE K+ + L ++++ + E L+ QE +A + + +E
Sbjct: 1987 RKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALE 2046
Query: 627 NIQTYQ----STAEENFLQEI---KNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQ 679
+QT +EN Q + K A++E + +K L + E + ++ K + Q
Sbjct: 2047 FVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQ 2106
Query: 680 ILKEELKKHSQENIKFENSISRL--TEDKILLENYVRSIENERDTLEFEMRHLQ 731
KE +K SQ K E+ RL E+K L E ++++ + D L E HL+
Sbjct: 2107 SNKESVK--SQMKQKDEDLERRLEQAEEKHLKEK--KNMQEKLDALRREKVHLE 2156
Score = 83.2 bits (204), Expect = 9e-16
Identities = 140/714 (19%), Positives = 280/714 (39%), Gaps = 88/714 (12%)
Query: 71 MQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSV--NVPSQIH 128
M+TL + + + + E + ME + ++L S ++ LS + V L + NV Q +
Sbjct: 1714 METLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLS-EEVQDLKHQIEGNVSKQAN 1772
Query: 129 SEDTLTL--RTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKS 186
E T +T+ + I +E D L PT +V S
Sbjct: 1773 LEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTR-----PTCSESVPSAKSA----NP 1823
Query: 187 KITVPFLKH----GFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNG 242
++ F H + + +D + I ++EE QK+ + L NE TL + ++G
Sbjct: 1824 AVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQIST-KDG 1882
Query: 243 KYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEA------LVKKLLPFRETVSKFH 296
+ M KMN + ++ + L+ K K +E E L+ +L ++ +
Sbjct: 1883 ELKMLQEEVTKMNLLNQQ-IQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNY- 1940
Query: 297 VHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMK 356
C+ ++ +++ KNE E+ K +++L+ + L + K +++
Sbjct: 1941 ------CQDVTDAQI----KNELLESEMKNLKKCVSELEEEKQQ-------LVKEKTKVE 1983
Query: 357 DKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENL 416
+ R+ +L K E S + E K Q ++ K+ ++ Q+K+ LE
Sbjct: 1984 SEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVK 2043
Query: 417 NLK----SKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFK 472
L+ K L T ++L Q VE +K L K + S+ + LK K
Sbjct: 2044 ALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKK 2103
Query: 473 KIISKYNVLQGQNKT-----------LEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMA 521
++ S ++ Q K EEK+++ EK+ M E LD L+ ++ + +
Sbjct: 2104 ELQSNKESVKSQMKQKDEDLERRLEQAEEKHLK---EKKNMQEKLDALRREKVHLEETIG 2160
Query: 522 IVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEI---IQ 578
+ N+ E++ ++ N+ + K L ++ + +E K+ + + IQ
Sbjct: 2161 EIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQ 2220
Query: 579 LKEKERLAKTE-----QETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQS 633
KE+E K + ++ L Q+ +++ K+N+ + + E++ Q
Sbjct: 2221 SKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCD 2280
Query: 634 TAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENI 693
T + + + + +Y +S +E+ K L+ ELK +
Sbjct: 2281 TLQGENKELLSQLEETRHLYHSSQNELAK------------------LESELKSLKDQLT 2322
Query: 694 KFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHND 747
NS+ + E K LE +R E + +F L+ + + + H +
Sbjct: 2323 DLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEE 2376
Score = 72.8 bits (177), Expect = 1e-12
Identities = 167/867 (19%), Positives = 353/867 (40%), Gaps = 173/867 (19%)
Query: 27 SEGVKESGCSDTE-YGCIAESENQIQPQSALKVLQQQL---ESFQALRMQTLQNVSMPTE 82
SE S C + E Y SE +++ Q K L+++L E FQAL Q Q + T
Sbjct: 1047 SEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKT- 1105
Query: 83 NQEENLSMEKSHHFED-SKTLHSVEEKLSGDSVNSLPQSVNVP-----SQIH-----SED 131
NQ + L E S + K + S + GDSV + ++V + S H E
Sbjct: 1106 NQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEK 1165
Query: 132 TLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVP 191
L L + L + + ILK R L + Q D D +++
Sbjct: 1166 ILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLRE---ELKQQKD----DYNRLQEQ 1218
Query: 192 FLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHR-----NGKYDM 246
F + + ++I ++Q++ ++++S DG++ T++ ++ + P + ++
Sbjct: 1219 FDEQS--KENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHT 1276
Query: 247 SPI-----------HQDKMNFIKEENLDGNLNEDIK-------------SKRISELEALV 282
P+ H + + ++ + +K S SEL
Sbjct: 1277 QPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKS 1336
Query: 283 KKLLPFRETVSK--------------FHVHFCRKCKKLSKSEM------HRGKKNEKNNK 322
+++ +E ++K VH +KL S++ H + K ++
Sbjct: 1337 EEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDE 1396
Query: 323 EIPITGKNITDLKFHS--------RVPRYTLSFLDQ--------TKHEMKDKERQPFLVK 366
+ K D+ + S + + ++Q T+ EM+ KE +K
Sbjct: 1397 LQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDE-RIK 1455
Query: 367 QGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLI 426
Q + E K + E+ AK Q +Q L+ ++ +K+ ++ EN +L+ ++
Sbjct: 1456 QLQV-ELCEMKQKPEEIGEESRAK-QQIQRKLQAALISRKEALK---ENKSLQEELSLAR 1510
Query: 427 FTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNK 486
T + L + + E Q+ +EK T+ +L+ +E + + E + + + L +
Sbjct: 1511 GTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCE 1570
Query: 487 TLEEKNIQLSLEKQQMMEALDQLKS-----------KEHKTQSDMAIVNNENNRMSIEME 535
+L+ L+ +K+++++ ++ LKS K + Q + I+ +S E E
Sbjct: 1571 SLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAE 1630
Query: 536 AMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKER-LAKTEQETLL 594
++ + ++ EK+ L K K +L+E++ E+ ++KEK R AK++Q+ +L
Sbjct: 1631 RIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKIL 1690
Query: 595 QIIETVKDEKLN-------------LETTLQESTAARQIMER---EIENI-QTYQS--TA 635
++ E ++++L +ET L + + ++ +ER E E + + +QS +
Sbjct: 1691 ELEE--ENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSE 1748
Query: 636 EENFLQEIKNAK--------------------SEASIYKNSLSEIGKECEMLSKMVMET- 674
+++ +E+++ K ++ ++ + I E E + M T
Sbjct: 1749 KDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTR 1808
Query: 675 ----------KTDNQILKEELKKHSQEN------IKFENSISRLTEDKILLENYVRSIEN 718
K+ N + ++ H + N + + I+ L E+K + + +++EN
Sbjct: 1809 PTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLEN 1868
Query: 719 ERDTL-------EFEMRHLQREYLSLS 738
E++TL + E++ LQ E ++
Sbjct: 1869 EKNTLLSQISTKDGELKMLQEEVTKMN 1895
Score = 72.4 bits (176), Expect = 2e-12
Identities = 167/848 (19%), Positives = 337/848 (39%), Gaps = 151/848 (17%)
Query: 4 EKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQQL 63
E E+D+++ L++ LN S G + C D A+ +N++ +S +K L++ +
Sbjct: 1913 ETAEEEKDDLEERLMNQLAELNGSIG---NYCQDVTD---AQIKNELL-ESEMKNLKKCV 1965
Query: 64 ESFQALRMQTL-QNVSMPTENQEENLSM---------EKSHHFEDSKTLHSVEEKLSG-- 111
+ + Q + + + +E ++E L KSH E + L ++++
Sbjct: 1966 SELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQ 2025
Query: 112 -------DSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFY 164
+ +++L ++V + +E L + +NL+ + +++
Sbjct: 2026 KDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELAS------ 2079
Query: 165 RFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHD---- 220
+ S+A V+ D K LK N + + +KQ E+L++ +
Sbjct: 2080 --FKVLLDDTQSEAARVLADNLK-----LKKELQSNKESVKSQMKQKDEDLERRLEQAEE 2132
Query: 221 ---------------------------GEVALT-----NELQTLQTDPD--VHRNGKY-- 244
GE+ +T E+Q LQ + D V + +
Sbjct: 2133 KHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTK 2192
Query: 245 DMSPIHQDKMNFIKE-ENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKC 303
MS + D+ I E + + ++ I+SK E+ ++ + + +H
Sbjct: 2193 SMSSLQDDRDRVIDEAKKWERKFSDAIQSKE-EEIRLKEDNCSVLKDQLRQMSIHMEELK 2251
Query: 304 KKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKH-------EMK 356
+S+ E + K E+ + K L+ ++ LS L++T+H E+
Sbjct: 2252 INISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKE---LLSQLEETRHLYHSSQNELA 2308
Query: 357 DKERQPFLVKQ------GSIISENEKTSKVNSVTEQCVAKIQ---YLQNYLKESVQIQKK 407
E + +K S+ E+ + + Q A IQ + L+ +Q ++
Sbjct: 2309 KLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRE 2368
Query: 408 VMELESENLNLKS-KMKPLIFTTQSLIQKV-----ETYEKQLKNLVEEKSTIQSKLSKTE 461
+ E +N+K K+ L+ + IQ + ++K++K L ++ LS+ E
Sbjct: 2369 LTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKEL-------ENLLSQEE 2421
Query: 462 EYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMA 521
E + +E KK + K N L KT++++NIQ + ++++ L++ + D
Sbjct: 2422 EENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQ 2481
Query: 522 IVNNENNRMSIEMEAMKTNILLIQD---EKEMLEKKTHQLLKEKSSLGNELKESQLEIIQ 578
+ E +SI +E + LIQ+ E L+++ L L +E + E+IQ
Sbjct: 2482 QL--EERHLSIILEKDQ----LIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQ 2535
Query: 579 LKE--------KERLAKTEQETLLQIIETVKDEKLNLETTLQESTAA------------- 617
+E K+ K E LQ + ++++ LE L+ES A
Sbjct: 2536 YREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQE 2595
Query: 618 -RQIMEREIENIQT--YQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMET 674
+Q + +EIE+++ Q T + LQE + +Y L +E LS + +
Sbjct: 2596 EKQDLSKEIESLKVSISQLTRQVTALQE----EGTLGLYHAQLKVKEEEVHRLSALFSSS 2651
Query: 675 KTDNQILKEELKKHSQENIKFENSI-SRLTEDKILLENYVRSIENERDTLEFEMRHLQRE 733
+ L+EEL +E K I +L ++ L + + NE +T E + L R+
Sbjct: 2652 QKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARD 2711
Query: 734 YLSLSDKI 741
+ + K+
Sbjct: 2712 LVEMEQKL 2719
Score = 71.6 bits (174), Expect = 3e-12
Identities = 116/614 (18%), Positives = 256/614 (41%), Gaps = 84/614 (13%)
Query: 199 ENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIK 258
+ L D+ +S+++ KE+ + + +G + Q + D+ +N K+ + D
Sbjct: 2319 DQLTDLSNSLEKCKEQ-KGNLEGIIR--------QQEADI-QNSKFSYEQLETDLQ---A 2365
Query: 259 EENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKN- 317
L L+E+I K + L K + +++ ++ K+L ++N
Sbjct: 2366 SRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENI 2425
Query: 318 ---EKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISEN 374
E+N K + T + + LK + + LD M + + G
Sbjct: 2426 VLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIV-GDYQQLE 2484
Query: 375 EKTSKVNSVTEQCVAKIQYLQNYLKESVQ-IQKKVMELESENLNLKSKMKPLIFTTQSLI 433
E+ + +Q + + N LKE ++ ++ + +L SEN L ++ LI + L
Sbjct: 2485 ERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAE---LIQYREDLN 2541
Query: 434 QKVETYEKQLKNLVE----EKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLE 489
Q + + Q K L+E + +++K +K EE KE + + + +N LQ + + L
Sbjct: 2542 QVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLS 2601
Query: 490 EKNIQLSLEKQQMMEALD-------------QLKSKEHKTQSDMAIVNNENNRMS----- 531
++ L + Q+ + QLK KE + A+ ++ R++
Sbjct: 2602 KEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEE 2661
Query: 532 ---IEMEAMKT-----------------NILLIQDEKEMLEKKTHQLLKEKSSLGNEL-- 569
++ EA K + ++++E E E++ +L ++ + +L
Sbjct: 2662 LVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLM 2721
Query: 570 --KESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQ--IMEREI 625
KE++ Q++ R + Q + E + + K + +L+E ++ ++ RE
Sbjct: 2722 VTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRER 2781
Query: 626 ENIQTY----QSTAEENFLQEIKN------AKSEASIYKNS-LSEIGKECEMLSKMVMET 674
+ + + ++ EEN L ++ +K E ++ +S L + + + SK +
Sbjct: 2782 DALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASL 2841
Query: 675 KTDNQILKEELKKHSQENIKFENSISRLTEDKI---LLENYVRSIENERDTLEFEMRHLQ 731
+ + L EL+K + + S ++ + L+ + S++N+RD L E+++LQ
Sbjct: 2842 QNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQ 2901
Query: 732 REYLSLSDKICNQH 745
++YL ++ +I H
Sbjct: 2902 QQYLQINQEITELH 2915
Score = 67.8 bits (164), Expect = 4e-11
Identities = 114/584 (19%), Positives = 241/584 (41%), Gaps = 59/584 (10%)
Query: 226 TNELQTLQTDPDVHRNGKYDMSPIHQDKMN--FIKEENLDGNLNEDIKSKRIS---ELEA 280
T++ DP++H+ + + Q+ + E L L + I+ K + + EA
Sbjct: 22 TDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEA 81
Query: 281 LVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRV 340
L ++ + K +H K L+K + + + +P ++ L H +
Sbjct: 82 LQEERKAADNKIKKLKLHAKAKLTSLNK---YIEEMKAQGGTVLPTEPQSEEQLSKHDKS 138
Query: 341 PRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKE 400
+++ KH++++KE ++ ++ E+ ++ ++ E+ V Q LQ +
Sbjct: 139 STEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEF 198
Query: 401 SVQIQKKVMELESENLNLK-SKMKPLIFTTQ--------------------------SLI 433
+Q ++ + ++E + + K F TQ L
Sbjct: 199 ISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQ 258
Query: 434 QKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNI 493
+K+E +E+ L + +Q +L+ E+ ++ ++ +++ +++N L+ +T E +
Sbjct: 259 RKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVET-EREES 317
Query: 494 QLSLEKQQMMEALDQLKSKEHKTQSDM-AIVNNENNRMSIEMEAMKTNILLIQDEKEMLE 552
++ LEK ++ A + K H Q +M ++ + E L Q K +E
Sbjct: 318 KILLEKMELEVA--ERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEME 375
Query: 553 KKTHQLL------KEKSSLGNELKESQLEIIQLKEKERL--AKTEQETLLQIIETVKD-- 602
+KT +L +E S + LK+ +++Q K ++ + A+T Q+ Q+ + K+
Sbjct: 376 EKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEIS 435
Query: 603 EKLNLETTLQESTAARQIMEREIENIQTYQSTAEENF------LQEIKNAKSEASIYKNS 656
+ LN LQ+ A Q ++ N T Q+ EEN + E++N K +
Sbjct: 436 QFLN-RLPLQQHETASQTSFPDVYNEGT-QAVTEENIASLQKRVVELENEKGALLLSSIE 493
Query: 657 LSEIGKECEMLSKMVMETKTDNQI--LKEELKKHSQENIKFENSISRLTEDKILLENYVR 714
L E+ E E LS + + N+ E+ + S +I + S S + +LEN
Sbjct: 494 LEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFS 553
Query: 715 SIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRRE 758
E L EM+ Q E L ++ + + + + ++E
Sbjct: 554 QKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKE 597
Score = 62.0 bits (149), Expect = 2e-09
Identities = 131/634 (20%), Positives = 246/634 (38%), Gaps = 122/634 (19%)
Query: 208 IKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQ-------DKMNFIKEE 260
IK +KE+L E A +++ + +MSP Q + + +K+E
Sbjct: 928 IKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKE 987
Query: 261 NLDGN-------LNEDIKSKRISELEALV-------KKLLPFRETV------SKFHVHFC 300
N +N +R+S LE + KK +P ET K + +
Sbjct: 988 NEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYS 1047
Query: 301 RKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKER 360
KC E+ K + KE+ + DL+ + + Q ++DK
Sbjct: 1048 EKCVTSKCQEIEIYLKQTISEKEVELQHIR-KDLEEKLAAEEQFQALVKQMNQTLQDKTN 1106
Query: 361 QPFLVKQGSIISENEK------TSKVNSVTEQCVAKIQYLQNYLKESV------------ 402
Q L++ + ISEN+ TS ++ VA + KE+V
Sbjct: 1107 QIDLLQ--AEISENQAIIQKLITSNTDASDGDSVALV-------KETVVISPPCTGSSEH 1157
Query: 403 ---QIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSK 459
++++K++ LE E L+ K++ + + +++++K + E+ L+ EE + ++
Sbjct: 1158 WKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLR---EELKQQKDDYNR 1214
Query: 460 TEEYSKECLKEFKKIISKYNVLQGQN----------------------------KTLEEK 491
+E E KE + I + LQ Q K E+
Sbjct: 1215 LQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQH 1274
Query: 492 NIQLSLEKQ----------------------QMMEALDQLKSKEHKTQSDMAIVNNENNR 529
+ Q LE Q+ L ++++++ + + ++ +E +
Sbjct: 1275 HTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTK 1334
Query: 530 MSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTE 589
S E+ ++ I E E L+ +H+ SL +L+ SQL+I L+ L + +
Sbjct: 1335 KSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLREL-QPK 1393
Query: 590 QETLLQIIETVKDEKLNLETTLQESTAA-----RQIMERE--IENIQTYQSTAEENFLQE 642
+ L ++I +++ L L E AA +I+E+E I+ + T + +
Sbjct: 1394 LDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDER 1453
Query: 643 IKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELK--KHSQENIKF-ENSI 699
IK + E K EIG+E ++ + + KE LK K QE + +I
Sbjct: 1454 IKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTI 1513
Query: 700 SRLTEDKILLENYVRSIENERDTLEFEMRHLQRE 733
RLT+ +E+ V + E+DT+ + LQ E
Sbjct: 1514 ERLTKSLADVESQVSAQNKEKDTVLGRLALLQEE 1547
Score = 60.5 bits (145), Expect = 6e-09
Identities = 143/787 (18%), Positives = 312/787 (39%), Gaps = 108/787 (13%)
Query: 44 AESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHH--FEDSKT 101
AE NQI L QQL+ +A TL+N ++ TE +E + +EK E +
Sbjct: 285 AEQRNQI--------LSQQLQQMEA-EHNTLRN-TVETEREESKILLEKMELEVAERKLS 334
Query: 102 LHSVEEKL---------SGDSVNSLPQSVNVPSQIHSEDT-------LTLRTSTDNLSSN 145
H+++E++ +G + L + Q H + L+L+ + L S
Sbjct: 335 FHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSA 394
Query: 146 IIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKH--------GF 197
+NS +L++ N + Q + + KSK FL
Sbjct: 395 CDALKDQNSKLLQDKNE----QAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETAS 450
Query: 198 CENLDDICHSIKQM--KEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMN 255
+ D+ + Q +E + V L NE L K + + ++
Sbjct: 451 QTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKL-SSQIT 509
Query: 256 FIKEENLDGNLNE--------DIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLS 307
++ +N G + DI +KR S E + +L T S+ H ++
Sbjct: 510 LLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVL--ENTFSQKHKELSVLLLEMK 567
Query: 308 KSEMH--------RGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEM---- 355
+++ +GK+ E+ + E+ + K + ++ P FL+ T +
Sbjct: 568 EAQEEIAFLKLQLQGKRAEEADHEV-LDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMP 626
Query: 356 KDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESEN 415
++ P + K+ + +TS+ S+ + V L++ ++ + V ++ +
Sbjct: 627 NEESSLPAVEKEQASTEHQSRTSEEISLNDAGVE----LKSTKQDGDKSLSAVPDIGQCH 682
Query: 416 LNLKSKMKPLIFTTQSLIQKV-ETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKI 474
+ ++K I + K E YEK L +E S + + + ++ + F +
Sbjct: 683 QDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTAL 742
Query: 475 ISKYNVLQGQNKTL--------EEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNE 526
+ + L Q K L + K ++++L + + LD H ++ +
Sbjct: 743 SEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDN-----LLTEQ 797
Query: 527 NNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLA 586
+ +SIE ++ I ++Q+E + ++ + + SL ++L+ + E+++ E+ R
Sbjct: 798 IHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHI 857
Query: 587 KTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQ--EIK 644
++ E L Q + + LE T + Q++ + +++T Q T EE Q EI
Sbjct: 858 SSKVEELSQAL-----SQKELEITKMD-----QLLLEKKRDVETLQQTIEEKDQQVTEIS 907
Query: 645 NAKSEASIYKNSLS-EIGKECEMLSKMVMETKTDNQILKEELKKHSQ------ENIKFEN 697
+ +E + N +G E + L + + + KE++++ ++ +N +
Sbjct: 908 FSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMS 967
Query: 698 SISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYL-----SLSDKICNQHNDPSKTT 752
+++++++ E + ENE+ + + + R+ L L +++ N ++ K
Sbjct: 968 PAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEI 1027
Query: 753 YISRREK 759
+S E+
Sbjct: 1028 PLSETER 1034
Score = 53.1 bits (126), Expect = 1e-06
Identities = 116/546 (21%), Positives = 218/546 (39%), Gaps = 125/546 (22%)
Query: 209 KQMKEELQKSHDGEVALTN---ELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGN 265
+Q E Q E++L + EL++ + D D + D+ HQD++ +K + L+
Sbjct: 638 EQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELE 697
Query: 266 LNEDIKSKRISE--LEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKE 323
LN K++ I E L+ K++ + + +F KKN NN
Sbjct: 698 LNFH-KAQEIYEKNLDEKAKEISNLNQLIEEF-------------------KKNADNNSS 737
Query: 324 IPITGKNITDLKFHSRVPRYTL-----SFLDQTKHEMKDKERQPFLVKQGSIISENEKTS 378
T + + S+V ++ + + Q + + + ERQ L + +N T
Sbjct: 738 A-FTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTE 796
Query: 379 KVNSVTEQCVAK---IQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQK 435
+++S++ + +K I+ LQN L + VQ+Q S+ LI + QS +Q
Sbjct: 797 QIHSLSIEAKSKDVKIEVLQNEL-DDVQLQF-------------SEQSTLIRSLQSQLQN 842
Query: 436 VETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQL 495
E+ ++E ++ SK EE S + L + + I+K + QL
Sbjct: 843 KES------EVLEGAERVRHISSKVEELS-QALSQKELEITKMD--------------QL 881
Query: 496 SLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKT 555
LEK++ +E L Q ++ + ++++ E K
Sbjct: 882 LLEKKRDVETLQQTIEEKDQQVTEISFSMTE---------------------------KM 914
Query: 556 HQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQEST 615
QL +EK SLG E+K LKE+ L +E + +E + L+ E +
Sbjct: 915 VQLNEEKFSLGVEIKT-------LKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMS 967
Query: 616 AARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETK 675
A QI + E+++ + +EN E + K +A++ E+L + V +
Sbjct: 968 PAGQISKEELQH--EFDLLKKEN---EQRKRKLQAALINRK--------ELLQR-VSRLE 1013
Query: 676 TDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRS--------IENERDTLEFEM 727
+ LK+E KK + + E+K E V S ++ E E+
Sbjct: 1014 EELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVEL 1073
Query: 728 RHLQRE 733
+H++++
Sbjct: 1074 QHIRKD 1079
Score = 48.5 bits (114), Expect = 2e-05
Identities = 75/383 (19%), Positives = 161/383 (42%), Gaps = 62/383 (16%)
Query: 447 VEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNV--------LQGQNKTLEEKNIQLSLE 498
+E +T Q + + Y+++ + E K II + +V LQ + K + K +L L
Sbjct: 40 MEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLH 99
Query: 499 KQQMMEAL----DQLKSK-----EHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKE 549
+ + +L +++K++ + QS+ + ++ + EME K L Q+++E
Sbjct: 100 AKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKL-QEKEE 158
Query: 550 MLEKKTHQLLK----EKSSLGNELKESQLEIIQLKEKE--------RLAKTEQETLLQII 597
++ QL + + + E++E + QL+EKE +L++T+ E Q +
Sbjct: 159 LISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQV 218
Query: 598 ETVKDEKLNLETTLQESTAARQIMEREIEN-----IQTYQSTAEEN-------------F 639
KD + + L E + + + ++E ++ Q EE+
Sbjct: 219 VREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLL 278
Query: 640 LQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELK-KHSQENIKFENS 698
QE+ A+ I L ++ E L V + +++IL E+++ + ++ + F N
Sbjct: 279 QQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNL 338
Query: 699 ISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRRE 758
+ LLE + ++ + + + L+ Y +L K ++ KT++I +
Sbjct: 339 QEEMHH---LLEQFEQAGQAQAE--------LESRYSALEQK--HKAEMEEKTSHILSLQ 385
Query: 759 KFHFDNYTHEDTSSPQSRPLASD 781
K + + D Q+ L D
Sbjct: 386 KTGQELQSACDALKDQNSKLLQD 408
Score = 36.2 bits (82), Expect = 0.12
Identities = 97/546 (17%), Positives = 206/546 (37%), Gaps = 60/546 (10%)
Query: 43 IAESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTL 102
I +E + + ++ + +E Q L M T +N + + Q SM + D
Sbjct: 2693 IMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANE 2752
Query: 103 HSVEEKLSGD-SVNSLPQSVNVPSQIHSEDTLTLRT--STDNLSSNIIIHPSENSDILKN 159
E K D S+ L Q D L T S ++ N + H + + L +
Sbjct: 2753 ELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLS 2812
Query: 160 YNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSH 219
+ L + + +Q + F + + + + + EL+K
Sbjct: 2813 KDEQLLHLSSQLEDSYNQVQS----------------FSKAMASLQNERDHLWNELEKFR 2856
Query: 220 DGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIK--SKRISE 277
E T P ++ K MS + D+ +KE NL + ++ I+E
Sbjct: 2857 KSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELK---NLQQQYLQINQEITE 2913
Query: 278 LEALVKKLLPFRETVSKFHV--HFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLK 335
L L +L +++ F + R+ + E+H+ + EK++ EI
Sbjct: 2914 LHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQ-LRMEKSSWEI----------- 2961
Query: 336 FHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQ 395
H R + +Q + DK++Q L ++I E +S ++ K+QY +
Sbjct: 2962 -HERRMK------EQYLMAISDKDQQ--LSHLQNLIRELRSSS-----SQTQPLKVQYQR 3007
Query: 396 NYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQS 455
E+ L E L++++ + +++ L+EEK+T+
Sbjct: 3008 QASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSI 3067
Query: 456 KLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHK 515
+L T + +E + + +++ VL+ Q + L+ + + + Q K+ H+
Sbjct: 3068 QLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNI-----DVAPGAPQEKNGVHR 3122
Query: 516 TQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLE 575
+SD + S + + + + +++LE++ Q + +++L + E Q+
Sbjct: 3123 -KSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENAL--SVAEEQIR 3179
Query: 576 IIQLKE 581
++ E
Sbjct: 3180 RLEHSE 3185
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 87.8 bits (216), Expect = 4e-17
Identities = 95/411 (23%), Positives = 198/411 (48%), Gaps = 42/411 (10%)
Query: 348 LDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKK 407
+ + + EM KE + V++ + +EN T ++ ++ Q +A+ LQ L+ ++ +
Sbjct: 840 VSRQEEEMMAKEEELVKVREKQLAAENRLT-EMETLQSQLMAEKLQLQEQLQAETELCAE 898
Query: 408 VMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKEC 467
EL + L +K + L L +VE E++ ++L EK +Q + + EE +E
Sbjct: 899 AEELRAR---LTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEE 955
Query: 468 LKEFKKII-------SKYNVLQGQNKTLEEKNIQLSLEKQ----QMMEALDQLKSKEHKT 516
+K+ +K L+ + LE++N +L+ EK+ ++ E L +E K+
Sbjct: 956 ESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKS 1015
Query: 517 QSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEI 576
+S +A + N++ M ++E + + +++ LEK +L + + L +++ E Q +I
Sbjct: 1016 KS-LAKLKNKHEAMITDLE---ERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQI 1071
Query: 577 IQLKEKERLAKTEQE---TLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQS 633
+L K +LAK E+E L ++ E + + L+ ++E + ++ ++E+ + ++
Sbjct: 1072 AEL--KMQLAKKEEELQAALARVEEEAAQKNMALK-KIRELESQISELQEDLESERASRN 1128
Query: 634 TAEE---NFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELK---- 686
AE+ + +E++ K+E +++L + E+ SK E + L+EE K
Sbjct: 1129 KAEKQKRDLGEELEALKTE---LEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEA 1185
Query: 687 -------KHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHL 730
KHSQ + + + K LE +++ENER L E++ L
Sbjct: 1186 QIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVL 1236
Score = 73.2 bits (178), Expect = 9e-13
Identities = 119/590 (20%), Positives = 257/590 (43%), Gaps = 68/590 (11%)
Query: 199 ENLDDICHS----IKQMKEELQKSHDGEVALTNELQTL--QTDPDVHRNGKYDMSPIHQD 252
+ L++ICH +++ +E Q + + +Q L Q + + K + + +
Sbjct: 911 QELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTE 970
Query: 253 -KMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPF------RETVSKFHVHFCRKCKK 305
K+ ++EE + + ED K E + L ++ F E SK K +
Sbjct: 971 AKLKKLEEEQI---ILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEA 1027
Query: 306 LSKSEMHRGKKNEKNNKEIPITGKNI----TDLKFHSRVPRYTLSFLDQTKHEMKDKERQ 361
+ R ++ EK +E+ T + + TDL + ++ L + + K++E Q
Sbjct: 1028 MITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAEL-KMQLAKKEEELQ 1086
Query: 362 PFLVK-QGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKS 420
L + + +N K+ + Q + L++ + +K+ +L E LK+
Sbjct: 1087 AALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKT 1146
Query: 421 KMKPLIFTT---QSLIQKVETYEKQLKNLVEEKST--------IQSKLSKTEEYSKECLK 469
+++ + +T Q L K E LK +EE++ ++ K S+ E E L+
Sbjct: 1147 ELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLE 1206
Query: 470 EFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQS---DMAIVNNE 526
+ K++ + L+ +TLE + +L+ E + +++ + K K ++ ++ + NE
Sbjct: 1207 QTKRVKAN---LEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNE 1263
Query: 527 NNRMSIEMEAMKTNILLIQDEKEML----EKKTHQLLKEKSSLGNELKESQLEIIQLKEK 582
R+ E+ T + + D L + K+ +L K+ S+L ++L+++Q E++Q + +
Sbjct: 1264 GERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQ-ELLQEENR 1322
Query: 583 ERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENF--- 639
++L+ + + ++ V+DEK + L+E A+ +E++I + + ++
Sbjct: 1323 QKLSLSTK------LKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDS 1376
Query: 640 ---LQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKT------DNQILKEELKKHSQ 690
L+ + K + LS+ +E + +TKT D+ ++ + ++ S
Sbjct: 1377 VGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSA 1436
Query: 691 ENI--KFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLS 738
N+ K + L E+K + Y ERD E E R + + LSL+
Sbjct: 1437 CNLEKKQKKFDQLLAEEKTISAKYA----EERDRAEAEAREKETKALSLA 1482
Score = 60.8 bits (146), Expect = 5e-09
Identities = 147/738 (19%), Positives = 298/738 (40%), Gaps = 94/738 (12%)
Query: 55 ALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSV 114
A++ L +QLE + ++ L+ EN+ L+ E + +K+ +
Sbjct: 1197 AVEELAEQLEQTKRVKAN-LEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQ-L 1254
Query: 115 NSLPQSVNVPSQIHSE--DTLT-LRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAP 171
L N ++ +E D +T L+ DN++ + S++S + K+++ L
Sbjct: 1255 QELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQ 1314
Query: 172 PNVMSQADTVILDKSKIT-VPFLKHGFCENLDDICHSIKQMKEELQKSH----DGEVALT 226
+ + + +K+ V K+ F E L++ + +++++ H D + +
Sbjct: 1315 ELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKME 1374
Query: 227 NELQTLQTDPDVHRNGKYDMSPIHQ---------DKMNFIK---EENLDGNLNE-DIKSK 273
+ + L+T +V R + D+ + Q DK+ K ++ LD L + D + +
Sbjct: 1375 DSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQ 1434
Query: 274 RISELEALVKK---LLPFRETVSKFHVHFC---------RKCKKLS-----------KSE 310
LE KK LL +T+S + ++ K LS K+E
Sbjct: 1435 SACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAE 1494
Query: 311 MHRGKKNEKNNKEIPIT-----GKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLV 365
+ R K + E ++ GK++ +L+ R L+Q EMK + +
Sbjct: 1495 LERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRA-------LEQQVEEMKTQLEELEDE 1547
Query: 366 KQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESV-QIQKKVMELESENLNLKSKMKP 424
Q + ++ + ++ Q +Q +E Q+ ++V E+E+E + + +
Sbjct: 1548 LQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSM 1607
Query: 425 LIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQ 484
+ + L ++ E + + + + +L K + K+C++E + + Q
Sbjct: 1608 AVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQ 1667
Query: 485 NKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLI 544
K E+K + E Q+ E L + + + Q E + ++ E+ L
Sbjct: 1668 AKENEKKLKSMEAEMIQLQEELAAAERAKRQAQ-------QERDELADEIANSSGKGALA 1720
Query: 545 QDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEK 604
+EK LE + QL +E E ++ E+I +RL K LQI + D
Sbjct: 1721 LEEKRRLEARIAQLEEEL-----EEEQGNTELI----NDRLKKAN----LQIDQINTD-- 1765
Query: 605 LNLETT-LQESTAARQIMEREIE----NIQTYQSTAEENFLQEIKNAKSEASIYKNSLSE 659
LNLE + Q++ ARQ +ER+ + +Q + T + + I +++ + + L
Sbjct: 1766 LNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDN 1825
Query: 660 IGKECEMLSKMVMET--KTDNQILKEELKKHSQENIK--FENSISRLTEDKILLENYVRS 715
KE + K V T K + +L+ + ++ + E K + + +RL + L+ +
Sbjct: 1826 ETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQ----LKRQLEE 1881
Query: 716 IENERDTLEFEMRHLQRE 733
E E R LQRE
Sbjct: 1882 AEEEAQRANASRRKLQRE 1899
Score = 47.8 bits (112), Expect = 4e-05
Identities = 111/627 (17%), Positives = 242/627 (38%), Gaps = 94/627 (14%)
Query: 5 KQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESEN-QIQPQSALKVLQQQL 63
+Q EE+E L L++ + D+ GC+ +E + + Q L+ L Q+
Sbjct: 1343 EQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDS-VGCLETAEEVKRKLQKDLEGLSQRH 1401
Query: 64 ESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNV 123
E + L+ + + ++L ++ H + + L ++K S
Sbjct: 1402 EE-KVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKY 1460
Query: 124 PSQIHSEDTLTLRTSTDNLS-SNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVI 182
+ + T LS + + E L+ N +R T ++MS D V
Sbjct: 1461 AEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFR---TEMEDLMSSKDDV- 1516
Query: 183 LDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNG 242
KS + K + ++++ ++++++ELQ + D ++ L LQ ++ + G
Sbjct: 1517 -GKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQG 1575
Query: 243 KYDMSPIHQDKMNFIKE-ENLDGNLNEDIKSKRIS-----ELEALVKKLLPFRETVSKFH 296
+ + S + K +++ ++ L ++ K + ++ +LE +K L ++ +K
Sbjct: 1576 RDEQS--EEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNR 1633
Query: 297 VHFCRKCKKL----------------SKSE-MHRGKKNEKNNKEIPITGKNITD-LKFHS 338
++ +KL S+ E + + K+NEK K + + + L
Sbjct: 1634 DEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAE 1693
Query: 339 RVPRYTLSFLDQTKHEMKDKERQPFLV--------------------KQGSIISENEKTS 378
R R D+ E+ + + L +QG+ N++
Sbjct: 1694 RAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLK 1753
Query: 379 KVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQS------- 431
K N +Q + +++ +++ ++ +LE +N LK K++ + T +S
Sbjct: 1754 KANLQIDQINTDLNLERSHAQKNENARQ---QLERQNKELKVKLQEMEGTVKSKYKASIT 1810
Query: 432 -LIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEE 490
L K+ E+QL N +E+ ++ +TE+ K+ L + + + + E+
Sbjct: 1811 ALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQ----------VDDERRNAEQ 1860
Query: 491 KNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEM 550
Q ++ + QL+ E + Q A +R ++ E ++D E
Sbjct: 1861 YKDQADKASTRLKQLKRQLEEAEEEAQRANA------SRRKLQRE--------LEDATET 1906
Query: 551 LEKKTHQLLKEKSSLGNELKESQLEII 577
+ +E SSL N+L+ L +
Sbjct: 1907 ADAMN----REVSSLKNKLRRGDLPFV 1929
Score = 40.4 bits (93), Expect = 0.007
Identities = 38/168 (22%), Positives = 76/168 (45%), Gaps = 16/168 (9%)
Query: 559 LKEKSSLGNELKESQLEIIQLKEKERLAK---TEQETLLQIIETVKDEKLNLETTLQEST 615
L + S E+ + E+++++EK+ A+ TE ETL + EKL L+ LQ T
Sbjct: 837 LLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMA---EKLQLQEQLQAET 893
Query: 616 ----------AARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECE 665
A ++E+E I E + ++ ++E + ++ E+ ++ E
Sbjct: 894 ELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLE 953
Query: 666 MLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYV 713
+ + + + +LKK +E I E+ +L ++K LLE+ +
Sbjct: 954 EEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRI 1001
Score = 30.8 bits (68), Expect = 5.2
Identities = 31/128 (24%), Positives = 53/128 (41%), Gaps = 9/128 (7%)
Query: 641 QEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSIS 700
+E+ + + +N L+E+ E L +M K L+E+L+ ++ + E +
Sbjct: 852 EELVKVREKQLAAENRLTEM----ETLQSQLMAEKLQ---LQEQLQAETELCAEAEELRA 904
Query: 701 RLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRREKF 760
RLT K LE +E + E +HLQ E + I Q + S R+K
Sbjct: 905 RLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNI--QELEEQLEEEESARQKL 962
Query: 761 HFDNYTHE 768
+ T E
Sbjct: 963 QLEKVTTE 970
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 83.2 bits (204), Expect = 9e-16
Identities = 152/728 (20%), Positives = 309/728 (42%), Gaps = 103/728 (14%)
Query: 62 QLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGD------SVN 115
+LE ALR+Q + + E+ + ++ S + + S++EKL +
Sbjct: 468 ELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSL--LQEISSLQEKLEVTRTDHQREIT 525
Query: 116 SLPQSVNVPSQIHSEDTLTLRTSTDNLS-------SNIIIHPSENSDILKNYNNFYRFLP 168
SL + + H ++ L T+T+ LS S + ENSD++ +
Sbjct: 526 SLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWK------- 578
Query: 169 TAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNE 228
S+ +T I + + LK F + L ++K +++K + +E
Sbjct: 579 -------SKLETAIASHQQ-AMEELKVSFSKGLGTETAEFAELKTQIEKMR---LDYQHE 627
Query: 229 LQTLQTDPDVHRNGKY-DMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLP 287
++ LQ D R +M + M IKE+ N E I+SK +A + L+
Sbjct: 628 IENLQNQQDSERAAHAKEMEALRAKLMKVIKEKE---NSLEAIRSKLD---KAEDQHLVE 681
Query: 288 FRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNN------KEIPITGKNITDLKFHSRVP 341
+T++K K+ + E+ + K NE+ ++ T + + DL +
Sbjct: 682 MEDTLNKLQEAEI----KVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKAS 737
Query: 342 RYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVA---KIQYLQNYL 398
S + + + +++ E+Q ++ I +N ++SK +S+T + K+ LQ L
Sbjct: 738 SEGKSEMKKLRQQLEAAEKQIKHLE----IEKNAESSKASSITRELQGRELKLTNLQENL 793
Query: 399 KESVQIQKKVMELESENLNLK---------SKMKPLIFTTQSLIQKVETYE---KQLKNL 446
E Q+ K+ +E E + L K S + + T L QK E + L+ L
Sbjct: 794 SEVSQV-KETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKL 852
Query: 447 VEEKSTIQSKLSKTEEYSKECLKEFKKI---ISKYNVLQGQNKT-LEEKNIQLSLEKQQM 502
E + +++K + +E ++ +K +K+ I++ + G N + L + N +L L+++ +
Sbjct: 853 RENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDV 912
Query: 503 MEA-LDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKE 561
E L K+ E+ + +I + + EA K + ++EK+ LE+K L K+
Sbjct: 913 EELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKH----EEEKKELERKLSDLEKK 968
Query: 562 KSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIE-TVKDEKLNLETTLQESTAARQI 620
+ N+ +E + + + KT+ E +LQ ++ T+ D + L+ +E++ Q
Sbjct: 969 METSHNQCQELKARYERATSE---TKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQ- 1024
Query: 621 MEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQI 680
E+E ++ A+ A A + ++ KE + +TK N
Sbjct: 1025 ---ELEELRKQADKAK---------AAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAK 1072
Query: 681 LKEELKKHSQENIKFENSISR----LTEDKILLENYVRSIENERDTL---EFEMRHLQRE 733
L+ EL + N+K +++ LT + +E + + IE + ++ LQ E
Sbjct: 1073 LQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEE 1132
Query: 734 YLSLSDKI 741
+ L++++
Sbjct: 1133 NVKLAEEL 1140
Score = 68.2 bits (165), Expect = 3e-11
Identities = 147/768 (19%), Positives = 310/768 (40%), Gaps = 111/768 (14%)
Query: 6 QHREEDEVDSVLLSASK----ILNSSEGVKESGCS-----DTEYGCIAESENQIQP---- 52
+H ++ D + L SK I + + ++E S TE AE + QI+
Sbjct: 564 EHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLD 623
Query: 53 -QSALKVLQQQLESFQALR---MQTLQNVSMPTENQEENL---------SMEKSHHFEDS 99
Q ++ LQ Q +S +A M+ L+ M ++EN E H E
Sbjct: 624 YQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEME 683
Query: 100 KTLHSVEE-KLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHP--SENSDI 156
TL+ ++E ++ + L N +++ T L+ + + L + SE
Sbjct: 684 DTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSE 743
Query: 157 LKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGF-CENLDDICHSIKQMKEEL 215
+K ++ + + S IT NL + + Q+KE L
Sbjct: 744 MKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETL 803
Query: 216 QKSHDGEVALTNE--LQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSK 273
+K E+ + E + + V R+ + ++ +HQ KEE + L+ D++
Sbjct: 804 EK----ELQILKEKFAEASEEAVSVQRSMQETVNKLHQ------KEEQFN-MLSSDLEKL 852
Query: 274 R--ISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNI 331
R ++++EA ++ E + K ++ K + K N E+ + +++
Sbjct: 853 RENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDV 912
Query: 332 TDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTS----------KVN 381
+L+ SFL ++ +M K Q ++ + E EK K+
Sbjct: 913 EELQLKLTKANENASFLQKSIEDMTVKAEQS--QQEAAKKHEEEKKELERKLSDLEKKME 970
Query: 382 SVTEQCVA-KIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYE 440
+ QC K +Y + + + ++ + L+ L+ + K+K L+Q++E
Sbjct: 971 TSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELR 1030
Query: 441 KQLKNL-----VEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQ- 494
KQ E+ I +++K + + L++ K+ +K LQ + TL+E N++
Sbjct: 1031 KQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAK---LQNELDTLKENNLKN 1087
Query: 495 ----------LSLEKQQMME---ALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNI 541
L++E Q+M E ++ LK + ++ + EN +++ E+ +
Sbjct: 1088 VEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRD-- 1145
Query: 542 LLIQDEKEMLEKKTHQLLKEKSSLGN----ELKESQLEIIQLKEKERLAKTEQETLLQII 597
E +HQ L+E+ S+ N E+K+ + + I+ ++E+ + + ++ +
Sbjct: 1146 ----------EVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSAL 1195
Query: 598 ETVKDEKL----NLETTLQESTAARQIMEREIENIQTYQSTAE---ENFLQEIKNAKSEA 650
T KD +L N T L+ A+ + + ++ +++ + E +N ++K K +
Sbjct: 1196 LTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQL 1255
Query: 651 SIYKNSLSEIGKECE--------MLSKMVMETKTDNQILKEELKKHSQ 690
S + E E L+ ++++ + NQ LK +++ S+
Sbjct: 1256 SSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1303
Score = 61.2 bits (147), Expect = 4e-09
Identities = 98/482 (20%), Positives = 199/482 (41%), Gaps = 80/482 (16%)
Query: 342 RYTLSFLDQTKHEMKDKERQPFLVKQGSI---------ISENEKTSKVNSVTEQCVAKIQ 392
R + L+Q + E + E F V++ SI +SE + ++ V ++
Sbjct: 422 REKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVA 481
Query: 393 YLQNYLKE---------SVQIQKKVMELESE-NLNLKSKMKPLIFTTQSLIQKVETYEKQ 442
L+ L+ S+ + +++ L+ + + + + + + ET++K+
Sbjct: 482 ELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKE 541
Query: 443 LK-------NLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQL 495
+K L +E +++SKL + + + + +K + + + +EE +
Sbjct: 542 IKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLE--TAIASHQQAMEELKVSF 599
Query: 496 SLEKQQMMEALDQLKSKEHKTQSDMA--IVNNENNRMSI------EMEAMKTNILLIQDE 547
S +LK++ K + D I N +N + S EMEA++ ++ + E
Sbjct: 600 SKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKE 659
Query: 548 KE--------MLEKKTHQLLKEKSSLGNELKESQ-----LEIIQLKEKER---------- 584
KE L+K Q L E N+L+E++ LE++Q K E+
Sbjct: 660 KENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQ 719
Query: 585 LAKTEQETL-LQIIETVKDE-KLNLETTLQESTAA-RQIMEREIENIQTYQSTAEENFLQ 641
L TE++ L L + E K ++ Q+ AA +QI EIE + +S+ + +
Sbjct: 720 LKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIE--KNAESSKASSITR 777
Query: 642 EIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISR 701
E++ + + + + +LSE+ + E L K + QILKE+ + S+E + + S+
Sbjct: 778 ELQGRELKLTNLQENLSEVSQVKETLEKEL-------QILKEKFAEASEEAVSVQRSMQE 830
Query: 702 LTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRREKFH 761
N + E + + L ++ L+ + K + D + I +EK
Sbjct: 831 TV-------NKLHQKEEQFNMLSSDLEKLRENLADMEAKF--REKDEREEQLIKAKEKLE 881
Query: 762 FD 763
D
Sbjct: 882 ND 883
Score = 53.1 bits (126), Expect = 1e-06
Identities = 114/599 (19%), Positives = 239/599 (39%), Gaps = 64/599 (10%)
Query: 2 SPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQ 61
S K+ R++ E + +I ++E K S + G + N + S + +++
Sbjct: 742 SEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKE 801
Query: 62 QLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEK---LSGDSVNSLP 118
LE +Q L+ E EE +S+++S E LH EE+ LS D
Sbjct: 802 TLEK----ELQILKEKF--AEASEEAVSVQRSMQ-ETVNKLHQKEEQFNMLSSDLEKLRE 854
Query: 119 QSVNVPSQIHSEDT-----LTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPN 173
++ ++ +D + + +N + I+ +NS L N+ R
Sbjct: 855 NLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEE 914
Query: 174 VMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVA-LTNELQTL 232
+ + L K+ FL+ ++++D+ +Q ++E K H+ E L +L L
Sbjct: 915 LQLK-----LTKANENASFLQ----KSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDL 965
Query: 233 QTDPDVHRNGKYDMSPIHQDKMNFIKE------ENLDGNL--NEDIKSKRISELEALVKK 284
+ + N ++ ++ + K +NL L ED E L+++
Sbjct: 966 EKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQE 1025
Query: 285 LLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEI--PITGKNITDLKFHSRVPR 342
L R+ K K + ++ M ++ K E + T+ K + +
Sbjct: 1026 LEELRKQADK------AKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDT 1079
Query: 343 YTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESV 402
+ L + K KE L + + E K ++ ++ + K Q L +E+V
Sbjct: 1080 LKENNLKNVEELNKSKE---LLTVENQKMEEFRK--EIETLKQAAAQKSQQLSALQEENV 1134
Query: 403 QIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEE 462
++ +++ E + + + L++ + K +K+ EEK+++Q +S T
Sbjct: 1135 KLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSA 1194
Query: 463 YSKECLKEFKKIISKYNVLQGQN----------KTLEEKNIQLSLE----KQQMMEALDQ 508
E E +K+ ++ VL+G+N +TLE ++L L+ + Q+ E Q
Sbjct: 1195 LLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQ 1254
Query: 509 LKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGN 567
L S T + + + +++ + + I+ +Q + + L+ K +++ E + GN
Sbjct: 1255 LSSSSGNTDTQ---ADEDERAQESQIDFLNSVIVDLQRKNQDLKMKV-EMMSEAALNGN 1309
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 83.2 bits (204), Expect = 9e-16
Identities = 152/728 (20%), Positives = 309/728 (42%), Gaps = 103/728 (14%)
Query: 62 QLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGD------SVN 115
+LE ALR+Q + + E+ + ++ S + + S++EKL +
Sbjct: 503 ELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSL--LQEISSLQEKLEVTRTDHQREIT 560
Query: 116 SLPQSVNVPSQIHSEDTLTLRTSTDNLS-------SNIIIHPSENSDILKNYNNFYRFLP 168
SL + + H ++ L T+T+ LS S + ENSD++ +
Sbjct: 561 SLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWK------- 613
Query: 169 TAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNE 228
S+ +T I + + LK F + L ++K +++K + +E
Sbjct: 614 -------SKLETAIASHQQ-AMEELKVSFSKGLGTETAEFAELKTQIEKMR---LDYQHE 662
Query: 229 LQTLQTDPDVHRNGKY-DMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLP 287
++ LQ D R +M + M IKE+ N E I+SK +A + L+
Sbjct: 663 IENLQNQQDSERAAHAKEMEALRAKLMKVIKEKE---NSLEAIRSKLD---KAEDQHLVE 716
Query: 288 FRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNN------KEIPITGKNITDLKFHSRVP 341
+T++K K+ + E+ + K NE+ ++ T + + DL +
Sbjct: 717 MEDTLNKLQEAEI----KVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKAS 772
Query: 342 RYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVA---KIQYLQNYL 398
S + + + +++ E+Q ++ I +N ++SK +S+T + K+ LQ L
Sbjct: 773 SEGKSEMKKLRQQLEAAEKQIKHLE----IEKNAESSKASSITRELQGRELKLTNLQENL 828
Query: 399 KESVQIQKKVMELESENLNLK---------SKMKPLIFTTQSLIQKVETYE---KQLKNL 446
E Q+ K+ +E E + L K S + + T L QK E + L+ L
Sbjct: 829 SEVSQV-KETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKL 887
Query: 447 VEEKSTIQSKLSKTEEYSKECLKEFKKI---ISKYNVLQGQNKT-LEEKNIQLSLEKQQM 502
E + +++K + +E ++ +K +K+ I++ + G N + L + N +L L+++ +
Sbjct: 888 RENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDV 947
Query: 503 MEA-LDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKE 561
E L K+ E+ + +I + + EA K + ++EK+ LE+K L K+
Sbjct: 948 EELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKH----EEEKKELERKLSDLEKK 1003
Query: 562 KSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIE-TVKDEKLNLETTLQESTAARQI 620
+ N+ +E + + + KT+ E +LQ ++ T+ D + L+ +E++ Q
Sbjct: 1004 METSHNQCQELKARYERATSE---TKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQ- 1059
Query: 621 MEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQI 680
E+E ++ A+ A A + ++ KE + +TK N
Sbjct: 1060 ---ELEELRKQADKAK---------AAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAK 1107
Query: 681 LKEELKKHSQENIKFENSISR----LTEDKILLENYVRSIENERDTL---EFEMRHLQRE 733
L+ EL + N+K +++ LT + +E + + IE + ++ LQ E
Sbjct: 1108 LQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEE 1167
Query: 734 YLSLSDKI 741
+ L++++
Sbjct: 1168 NVKLAEEL 1175
Score = 68.2 bits (165), Expect = 3e-11
Identities = 147/768 (19%), Positives = 310/768 (40%), Gaps = 111/768 (14%)
Query: 6 QHREEDEVDSVLLSASK----ILNSSEGVKESGCS-----DTEYGCIAESENQIQP---- 52
+H ++ D + L SK I + + ++E S TE AE + QI+
Sbjct: 599 EHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLD 658
Query: 53 -QSALKVLQQQLESFQALR---MQTLQNVSMPTENQEENL---------SMEKSHHFEDS 99
Q ++ LQ Q +S +A M+ L+ M ++EN E H E
Sbjct: 659 YQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEME 718
Query: 100 KTLHSVEE-KLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHP--SENSDI 156
TL+ ++E ++ + L N +++ T L+ + + L + SE
Sbjct: 719 DTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSE 778
Query: 157 LKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGF-CENLDDICHSIKQMKEEL 215
+K ++ + + S IT NL + + Q+KE L
Sbjct: 779 MKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETL 838
Query: 216 QKSHDGEVALTNE--LQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSK 273
+K E+ + E + + V R+ + ++ +HQ KEE + L+ D++
Sbjct: 839 EK----ELQILKEKFAEASEEAVSVQRSMQETVNKLHQ------KEEQFN-MLSSDLEKL 887
Query: 274 R--ISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNI 331
R ++++EA ++ E + K ++ K + K N E+ + +++
Sbjct: 888 RENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDV 947
Query: 332 TDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTS----------KVN 381
+L+ SFL ++ +M K Q ++ + E EK K+
Sbjct: 948 EELQLKLTKANENASFLQKSIEDMTVKAEQS--QQEAAKKHEEEKKELERKLSDLEKKME 1005
Query: 382 SVTEQCVA-KIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYE 440
+ QC K +Y + + + ++ + L+ L+ + K+K L+Q++E
Sbjct: 1006 TSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELR 1065
Query: 441 KQLKNL-----VEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQ- 494
KQ E+ I +++K + + L++ K+ +K LQ + TL+E N++
Sbjct: 1066 KQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAK---LQNELDTLKENNLKN 1122
Query: 495 ----------LSLEKQQMME---ALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNI 541
L++E Q+M E ++ LK + ++ + EN +++ E+ +
Sbjct: 1123 VEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRD-- 1180
Query: 542 LLIQDEKEMLEKKTHQLLKEKSSLGN----ELKESQLEIIQLKEKERLAKTEQETLLQII 597
E +HQ L+E+ S+ N E+K+ + + I+ ++E+ + + ++ +
Sbjct: 1181 ----------EVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSAL 1230
Query: 598 ETVKDEKL----NLETTLQESTAARQIMEREIENIQTYQSTAE---ENFLQEIKNAKSEA 650
T KD +L N T L+ A+ + + ++ +++ + E +N ++K K +
Sbjct: 1231 LTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQL 1290
Query: 651 SIYKNSLSEIGKECE--------MLSKMVMETKTDNQILKEELKKHSQ 690
S + E E L+ ++++ + NQ LK +++ S+
Sbjct: 1291 SSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1338
Score = 62.4 bits (150), Expect = 2e-09
Identities = 115/557 (20%), Positives = 225/557 (40%), Gaps = 91/557 (16%)
Query: 266 LNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNE---KNNK 322
L D + + ELEA + +L E + K + L++ E + K + + +
Sbjct: 394 LARDGHDQHVLELEAKMDQLRTMVEAADR------EKVELLNQLEEEKRKVEDLQFRVEE 447
Query: 323 EIPITGKNITDLKF-HSRVPRYTLSFL------DQTKHEMKDKERQPFLVKQGSIISENE 375
E G T K H+R+ S L D+ + E++D K + E +
Sbjct: 448 ESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKD 507
Query: 376 KTSKVNSVTE--------QCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIF 427
+V V E + + + L+E +Q+K+ +++ + +K
Sbjct: 508 LALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLK---- 563
Query: 428 TTQSLIQKVETYEKQLK-------NLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNV 480
+ + ET++K++K L +E +++SKL + + + + +K +
Sbjct: 564 --EHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLE--TA 619
Query: 481 LQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMA--IVNNENNRMSI------ 532
+ + +EE + S +LK++ K + D I N +N + S
Sbjct: 620 IASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAK 679
Query: 533 EMEAMKTNILLIQDEKE--------MLEKKTHQLLKEKSSLGNELKESQ-----LEIIQL 579
EMEA++ ++ + EKE L+K Q L E N+L+E++ LE++Q
Sbjct: 680 EMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQA 739
Query: 580 KEKER----------LAKTEQETL-LQIIETVKDE-KLNLETTLQESTAA-RQIMEREIE 626
K E+ L TE++ L L + E K ++ Q+ AA +QI EIE
Sbjct: 740 KCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIE 799
Query: 627 NIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELK 686
+ +S+ + +E++ + + + + +LSE+ + E L K + QILKE+
Sbjct: 800 --KNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKEL-------QILKEKFA 850
Query: 687 KHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHN 746
+ S+E + + S+ N + E + + L ++ L+ + K +
Sbjct: 851 EASEEAVSVQRSMQETV-------NKLHQKEEQFNMLSSDLEKLRENLADMEAKF--REK 901
Query: 747 DPSKTTYISRREKFHFD 763
D + I +EK D
Sbjct: 902 DEREEQLIKAKEKLEND 918
Score = 53.1 bits (126), Expect = 1e-06
Identities = 114/599 (19%), Positives = 239/599 (39%), Gaps = 64/599 (10%)
Query: 2 SPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQ 61
S K+ R++ E + +I ++E K S + G + N + S + +++
Sbjct: 777 SEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKE 836
Query: 62 QLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEK---LSGDSVNSLP 118
LE +Q L+ E EE +S+++S E LH EE+ LS D
Sbjct: 837 TLEK----ELQILKEKF--AEASEEAVSVQRSMQ-ETVNKLHQKEEQFNMLSSDLEKLRE 889
Query: 119 QSVNVPSQIHSEDT-----LTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPN 173
++ ++ +D + + +N + I+ +NS L N+ R
Sbjct: 890 NLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEE 949
Query: 174 VMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVA-LTNELQTL 232
+ + L K+ FL+ ++++D+ +Q ++E K H+ E L +L L
Sbjct: 950 LQLK-----LTKANENASFLQ----KSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDL 1000
Query: 233 QTDPDVHRNGKYDMSPIHQDKMNFIKE------ENLDGNL--NEDIKSKRISELEALVKK 284
+ + N ++ ++ + K +NL L ED E L+++
Sbjct: 1001 EKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQE 1060
Query: 285 LLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEI--PITGKNITDLKFHSRVPR 342
L R+ K K + ++ M ++ K E + T+ K + +
Sbjct: 1061 LEELRKQADK------AKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDT 1114
Query: 343 YTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESV 402
+ L + K KE L + + E K ++ ++ + K Q L +E+V
Sbjct: 1115 LKENNLKNVEELNKSKE---LLTVENQKMEEFRK--EIETLKQAAAQKSQQLSALQEENV 1169
Query: 403 QIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEE 462
++ +++ E + + + L++ + K +K+ EEK+++Q +S T
Sbjct: 1170 KLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSA 1229
Query: 463 YSKECLKEFKKIISKYNVLQGQN----------KTLEEKNIQLSLE----KQQMMEALDQ 508
E E +K+ ++ VL+G+N +TLE ++L L+ + Q+ E Q
Sbjct: 1230 LLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQ 1289
Query: 509 LKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGN 567
L S T + + + +++ + + I+ +Q + + L+ K +++ E + GN
Sbjct: 1290 LSSSSGNTDTQ---ADEDERAQESQIDFLNSVIVDLQRKNQDLKMKV-EMMSEAALNGN 1344
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 82.4 bits (202), Expect = 1e-15
Identities = 142/703 (20%), Positives = 280/703 (39%), Gaps = 98/703 (13%)
Query: 43 IAESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTL 102
+ ESEN+ L+ LQQ+ E+++ R+ L++ + + +N S + + H E K
Sbjct: 548 LTESENK------LRDLQQEAETYRT-RILELESSLEKSLQENKNQSKDLAVHLEAEKNK 600
Query: 103 HSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNN 162
H+ E + V + H + +L+ D L + E +LK
Sbjct: 601 HNKE--------------ITVMVEKHKTELESLKHQQDALWT-------EKLQVLKQ--Q 637
Query: 163 FYRFLPTAPPNVMSQADTVILDKSKIT---VPFLKHGFCENLDDICHSIKQMKEELQKSH 219
+ + + +T++ DK I + + E LD ++ + EL +
Sbjct: 638 YQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVL 697
Query: 220 DGEVALTNELQTLQTDPDVHRN---GKYDMSPIHQDKM--NFIKEENLDGNLNEDIKSKR 274
L EL L+ D + K D H + + IKE + E +
Sbjct: 698 KARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQ 757
Query: 275 ISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDL 334
I++LE L+K+ + K L + + H N E I ++ +L
Sbjct: 758 INQLELLLKE-----------------RDKHLKEHQAH------VENLEADIK-RSEGEL 793
Query: 335 KFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYL 394
+ S S+ T + K E Q ++Q + E E+ V E K
Sbjct: 794 QQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVC 853
Query: 395 QNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQ 454
+Q+Q + +LE +N ++ K+K L +S ++ ++Q K ++ EK +
Sbjct: 854 TELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMI 913
Query: 455 SKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEH 514
++ + ++ E L + K+ +K + + N+ E K +++ ME + Q K+KE
Sbjct: 914 LQMREGQKKEIEILTQ--KLSAKEDSIHILNEEYETK----FKNQEKKMEKVKQ-KAKEM 966
Query: 515 KTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQL 574
+ +++ E ++ E T + L Q EK+ K + + +S G S+L
Sbjct: 967 QETLKKKLLDQE---AKLKKELENTALELSQKEKQFNAKMLE--MAQANSAGISDAVSRL 1021
Query: 575 EIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQST 634
E Q ++ E L + + L +I ++ ++KLN + + Q+ E+E
Sbjct: 1022 ETNQKEQIESLTEVHRRELNDVI-SIWEKKLNQQAEELQEIHEIQLQEKE---------- 1070
Query: 635 AEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIK 694
QE+ K + ++ E+ KE L + ++ T L+E+LK+ S
Sbjct: 1071 ------QEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAH--- 1121
Query: 695 FENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSL 737
++ L +D+ L+ ++ +E + + E LQ + + L
Sbjct: 1122 ----VNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVEL 1160
Score = 75.5 bits (184), Expect = 2e-13
Identities = 135/619 (21%), Positives = 262/619 (42%), Gaps = 91/619 (14%)
Query: 199 ENLDDICHSIKQMKEEL--------QKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIH 250
++L+D K++ EEL +K+ A TNEL + + N
Sbjct: 1197 KSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKT---NAILSRISHC 1253
Query: 251 QDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSE 310
Q + +KE L IK+ +SELEA +++L + T++ + F + +L + E
Sbjct: 1254 QHRTTKVKEALL-------IKTCTVSELEAQLRQLTEEQNTLN---ISFQQATHQLEEKE 1303
Query: 311 MHRGKKNEKNNKEIPITGKNITDLKF--HSRVPRYTLSFLDQTKHEMKDKERQPFLVKQG 368
K+ K + E +T K + + S + Q K E+ + L+K+
Sbjct: 1304 NQI--KSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKE- 1360
Query: 369 SIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFT 428
EK +++S+++Q LQN S+ + +K + S + L+
Sbjct: 1361 ---ELKEKKVEISSLSKQLTDLNVQLQN----SISLSEKEAAISSLRKQYDEEKCELLDQ 1413
Query: 429 TQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNV-LQGQNKT 487
Q L KV+T K+ + +E+ +K S+ ++ ++ + + + + + L+ ++K
Sbjct: 1414 VQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKE 1473
Query: 488 LEEKNIQLSLEKQQMMEA----------LDQLKSKEHKTQSDMAI-----------VNNE 526
EK+ Q++L K+++ + ++ KSK K +S++ + +
Sbjct: 1474 AYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDH 1533
Query: 527 NNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLG----NELKESQLEIIQLKEK 582
+ +IE+E++ + +K++ K+ Q L+ LG N +KE++ +I+ L+ +
Sbjct: 1534 ITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQ 1593
Query: 583 ERLAKTEQETLLQIIETV------KDEKLN-LETTLQESTAA-----RQIMEREIENI-Q 629
K E ET + +E V K+E+L LE L+ +AA ++ E++I I +
Sbjct: 1594 VYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKK 1653
Query: 630 TYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLS---KMVMETKTDNQILKEELK 686
S EE Q K +S S L E +E +L K V ++++ I+ K
Sbjct: 1654 QLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAK 1713
Query: 687 K----HSQENIKFENSISRLTEDKILL--------ENYVRSIENERD---TLEFEMR-HL 730
QE + + + E+KI + E ++ + E++ + FEMR
Sbjct: 1714 NVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQY 1773
Query: 731 QREYLSLSDKICNQHNDPS 749
Q + L QH D S
Sbjct: 1774 QERLIKLEHAEAKQHEDQS 1792
Score = 63.5 bits (153), Expect = 7e-10
Identities = 140/664 (21%), Positives = 262/664 (39%), Gaps = 172/664 (25%)
Query: 208 IKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDK-MNFIKEENLDGNL 266
I QM+E +K E+ + + + + D N +Y+ +Q+K M +K++ + +
Sbjct: 913 ILQMREGQKK----EIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKE--M 966
Query: 267 NEDIKSKRISELEALVKKL----LPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNK 322
E +K K + + L K+L L + +F+ + S + E N K
Sbjct: 967 QETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQK 1026
Query: 323 EIPITGKNITDLKFHSRVPRYTLSFLD----------QTKHE--MKDKERQPFLVKQGSI 370
E +++T++ H R +S + Q HE +++KE++ +KQ +
Sbjct: 1027 E---QIESLTEV--HRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKIL 1081
Query: 371 ISENEKTSKVNSVT---EQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPL-I 426
+ EK +T E+ V + L ++ Q V L + LK+ ++ L +
Sbjct: 1082 LFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEV 1141
Query: 427 FTTQSLIQKVETYEK--QLKNLVEEK----STIQSKLSKTEEYSKECLKEFKKIISKYNV 480
+SL + E+ +LK L EE S + SKL T+E EF+ + S +
Sbjct: 1142 DLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDE-------EFQSLKSSH-- 1192
Query: 481 LQGQNKTLEEKNIQLSLEKQQM----------MEALDQLKSKE----------------- 513
+ NK+LE+K+++ +++ EAL + K+ E
Sbjct: 1193 -EKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRIS 1251
Query: 514 ---HKT-----------------QSDMAIVNNENNRMSI--------------EMEAMKT 539
H+T ++ + + E N ++I ++++MK
Sbjct: 1252 HCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKA 1311
Query: 540 NILLIQDEKEMLEKK---THQLLKEKSS------------------LGNELKESQLEI-- 576
+I + EKE L+K+ Q EK S + ELKE ++EI
Sbjct: 1312 DIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISS 1371
Query: 577 ---------------IQLKEKE----RLAKTEQETLLQIIETVKDEKLNLETTLQESTAA 617
I L EKE L K E ++++ V+D ++T +E +A
Sbjct: 1372 LSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISA 1431
Query: 618 RQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTD 677
+E + + + F + K A+S + ++N++ E+ + E+ SK E
Sbjct: 1432 -------LEQVDDWSN----KFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQ 1480
Query: 678 NQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSL 737
+LKEEL Q+N +F+ + +DK +E + LE E++ + L
Sbjct: 1481 INLLKEEL---DQQNKRFDCLKGEMEDDK-------SKMEKKESNLETELKSQTARIMEL 1530
Query: 738 SDKI 741
D I
Sbjct: 1531 EDHI 1534
Score = 56.2 bits (134), Expect = 1e-07
Identities = 97/464 (20%), Positives = 204/464 (43%), Gaps = 81/464 (17%)
Query: 349 DQTKHEMKDKERQPFLVKQGSIISENE-----KTSKVNSVTE--------------QCVA 389
D++K E K+ + L Q + I E E KT ++ S+ E + V
Sbjct: 1505 DKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQ 1564
Query: 390 KIQYLQNYLKES----VQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKN 445
K+Q+ Q +E + ++K++ LE++ ++K++++ + + V++ E++LK
Sbjct: 1565 KLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKA 1624
Query: 446 LVEE-KSTIQSKLSKTEEYSKECLKEFKK-IISKYNVLQGQNKT-----LEEKNIQLSLE 498
L + +S +KL++ + +++ + KK ++S+ + Q K L E N +L
Sbjct: 1625 LEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQER 1684
Query: 499 KQQMMEALDQLKSKEHKTQSDMAIV------------NNENNRMSIEMEAMKTNILLIQ- 545
++++ ++LKS E +QS+ IV E + + + I ++Q
Sbjct: 1685 EREVHILEEKLKSVE-SSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQR 1743
Query: 546 --DEKEMLEKKTHQLLKEKSSLGNELK-ESQLEIIQLKEKERLAKTEQETLLQIIETVKD 602
EKE L ++ Q +E S E++ + Q +I+L+ E +Q + + E +++
Sbjct: 1744 NLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEE 1803
Query: 603 EKLNLETTLQE---------STAARQIMEREIENIQTYQSTAEENFL------QEIKNAK 647
+ + + + A+Q +E +++Q T +E L Q+IK
Sbjct: 1804 KNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQ---KTLQEKELTCQILEQKIKELD 1860
Query: 648 S----EASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLT 703
S + +++ + E+ + E L + + D + EL + + E E S S L
Sbjct: 1861 SCLVRQKEVHRVEMEELTSKYEKLQAL---QQMDGRNKPTELLEENTE----EKSKSHLV 1913
Query: 704 EDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHND 747
+ K+L ++E + + LEF++ +RE L +I D
Sbjct: 1914 QPKLL-----SNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKD 1952
Score = 47.4 bits (111), Expect = 5e-05
Identities = 151/760 (19%), Positives = 303/760 (39%), Gaps = 142/760 (18%)
Query: 5 KQHREEDEVDSVLLS-ASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQQL 63
K ++E +++ L S ++I+ + + + + ++ NQ Q K L Q+L
Sbjct: 1508 KMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQ-QKDIEHKELVQKL 1566
Query: 64 ESFQAL-------------RMQTLQN--VSMPTENQEENLSMEKSHHFEDSKT--LHSVE 106
+ FQ L ++ TL+N SM E + + +E + SK L ++E
Sbjct: 1567 QHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALE 1626
Query: 107 EKLSGDSVNSLPQSVNVPSQ----IHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNN 162
++L +S L + Q I + + + H SE + L+
Sbjct: 1627 DRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQERER 1686
Query: 163 FYRFLPTAPPNV-MSQADTVILDKS-KITVPFLKHGFCENLDDICHSIKQMKEELQKSHD 220
L +V SQ++T+I+ +S K + + ++ + + ++ LQ++
Sbjct: 1687 EVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLT 1746
Query: 221 GEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEA 280
+ L LQ + + + + ++M +Q+++ IK E+ + +ED I L+
Sbjct: 1747 EKEKL---LQRVGQEKEETVSSHFEMRCQYQERL--IKLEHAEAKQHED--QSMIGHLQE 1799
Query: 281 LVKKLLPFRETVSKFHVHFCRKCKKLSKS-EMHRGKKNEKNNKEIPITGKNI-TDLKFHS 338
+++ K KK S H K+ KNN + +N+ D++
Sbjct: 1800 ELEE-----------------KNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTL 1842
Query: 339 RVPRYTLSFLDQTKHEMKDKERQPFLVKQGSI--ISENEKTSKVNSVTEQCVAKIQYLQN 396
+ T L+Q K KE LV+Q + + E TSK K+Q LQ
Sbjct: 1843 QEKELTCQILEQ-----KIKELDSCLVRQKEVHRVEMEELTSKYE--------KLQALQQ 1889
Query: 397 Y---------LKESVQ-------IQKKVME-LESENLNLKSKMKPLIFTTQSLIQKVETY 439
L+E+ + +Q K++ +E+++ +L+ K+ Q L +++
Sbjct: 1890 MDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRL 1949
Query: 440 EKQLKNLVEEKSTIQSKLSKT-EEYSKECLKE------------FKKIISKYNVLQGQNK 486
+K L+ L +E L K ++ +E +K+ K+++ ++N Q +
Sbjct: 1950 QKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKE 2009
Query: 487 TLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMS-----------IEME 535
E I+ ++ K Q +EA + L+S + +T + + +++ + E
Sbjct: 2010 QELEMTIKETINKAQEVEA-ELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREE 2068
Query: 536 AMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQ 595
M + +Q + E L+KK Q L+++ + GN+ + I++L Q L Q
Sbjct: 2069 EMTAKVRDLQTQLEELQKKYQQKLEQEENPGND----NVTIMEL----------QTQLAQ 2114
Query: 596 IIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEEN-FLQEIKNAKSEASIYK 654
+ D KL Q +I N++ E+N + + ++Y
Sbjct: 2115 KTTLISDSKLK-----------EQEFREQIHNLEDRLKKYEKNVYATTVGTPYKGGNLYH 2163
Query: 655 NSLSEIGK--ECEMLSKMVM------ETKTDNQILKEELK 686
+S G+ E E L K++ ETKT +++ LK
Sbjct: 2164 TDVSLFGEPTEFEYLRKVLFEYMMGRETKTMAKVITTVLK 2203
Score = 45.1 bits (105), Expect = 3e-04
Identities = 73/381 (19%), Positives = 169/381 (44%), Gaps = 86/381 (22%)
Query: 430 QSLIQKVETYEKQLKN--------------LVEEKSTIQSKLSKTEEYSKECLKEFKKII 475
+ LIQ++ E+ L + L EK +Q LS++++ S + E ++ +
Sbjct: 137 EQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREEL 196
Query: 476 -----SKYNVLQGQNKTLEEKN-------IQLSLEKQQM---------MEALDQLK---- 510
+K ++ + + +LEEK+ Q+SL KQ++ ++ L QL+
Sbjct: 197 QMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAE 256
Query: 511 --SKEHKTQSD------------------MAIVNNEN--NRMSIEMEAMKTNILLIQDEK 548
+KE +SD + EN R +++ K L+ EK
Sbjct: 257 VFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEK 316
Query: 549 EMLEKKTHQLLKE-----------KSSLGNELKESQLEIIQLKEKERLAKTE-QETLLQI 596
E L+++ + L+E K+ L +L++++ I QL++ + + E + + +
Sbjct: 317 EALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHET 376
Query: 597 IETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNS 656
+E ++E L + +++ T + E ++ + +E +E++ A S A + +
Sbjct: 377 LEMKEEEIAQLRSRIKQMTT-------QGEELREQKEKSERAAFEELEKALSTAQKTEEA 429
Query: 657 LSEIGKECEMLSKMVMETKTDNQI-LKEELKKHSQENIKFENSISRLTEDKI--LLENYV 713
++ E + K + +T + +I L++EL + QE + + + + +E++I L + +
Sbjct: 430 RRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVV---DVMKKSSEEQIAKLQKLHE 486
Query: 714 RSIENERDTLEFEMRHLQREY 734
+ + + L +++ +RE+
Sbjct: 487 KELARKEQELTKKLQTREREF 507
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 82.0 bits (201), Expect = 2e-15
Identities = 158/800 (19%), Positives = 309/800 (38%), Gaps = 109/800 (13%)
Query: 45 ESEN----QIQPQSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSK 100
E EN +++ + A+K + ++E + L LQ E L+ ++H+ E+
Sbjct: 1149 EKENLGWQKLESEKAIKEKEYEIERLRVL----LQEEGTRKREYENELAKVRNHYNEEMS 1204
Query: 101 TLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSE----NSDI 156
L + E +N ++ S +D+ LR D LS E N I
Sbjct: 1205 NLRNKYET----EINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSI 1260
Query: 157 LKNYNNFYRFLPTAPPNVMSQ--ADTVILDKSKITVPFLKHGFCENLDDICH-------- 206
L+ R A N + Q + I+ K + LK + +D
Sbjct: 1261 LQATEQRRR----AEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEA 1316
Query: 207 ---------SIKQMKEELQKSHDGEVALTNELQTLQTDPD---VHRNGKYDM------SP 248
I+++K E Q+ NEL ++ + D + +++ +
Sbjct: 1317 AKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTT 1376
Query: 249 IHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSK 308
IHQ M KEE+ G + R E +L +++ + T+++ + R+ ++ +
Sbjct: 1377 IHQLTMQ--KEEDTSGYRAQIDNLTR--ENRSLSEEIKRLKNTLTQTTENL-RRVEEDIQ 1431
Query: 309 SEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQG 368
+ G + + +++ + + +T ++ V RY S LD ++DK ++ +KQ
Sbjct: 1432 QQKATGSEVSQRKQQLEVELRQVTQMRTEESV-RYKQS-LDDAAKTIQDKNKEIERLKQ- 1488
Query: 369 SIISENEKTSKVNSVTEQCVAKIQY-LQNYLKESVQIQKKVMELESENLNLKSKMKPLIF 427
+I + K + ++QY LQ + + K+ E E L+ + +
Sbjct: 1489 -LIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQ 1547
Query: 428 TTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKT 487
Q + ++ LK L +K ++ +L++ + + E + KK+ + L+G ++
Sbjct: 1548 ERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEE---LEGMRRS 1604
Query: 488 LEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNN----------ENNRMSIEMEAM 537
L+E+ I+++ QQ+ +A K E + +++ E R+S E+EA+
Sbjct: 1605 LKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEAL 1664
Query: 538 KTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQII 597
+ +L Q+ + + K L ES++EI E L +
Sbjct: 1665 RRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEI--------------ERLQSLT 1710
Query: 598 ETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSL 657
E + E L LE L+ + E ++++ +S A+ + I +S+ I N
Sbjct: 1711 ENLTKEHLMLEEELRN-------LRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRT 1763
Query: 658 SEIG--------------KECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLT 703
E+ +E E K +E Q K + + QE I L
Sbjct: 1764 LELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLE 1823
Query: 704 EDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRREKFHFD 763
+DK L+ + + TLE E R QR L + + KT Y SR+E+
Sbjct: 1824 QDKARLQRLEDELNRAKSTLEAETRVKQR--LECEKQQIQNDLNQWKTQY-SRKEEAIRK 1880
Query: 764 NYTHEDTSSPQSRPLASDLK 783
+ + S + L S+++
Sbjct: 1881 IESEREKSEREKNSLRSEIE 1900
Score = 61.2 bits (147), Expect = 4e-09
Identities = 91/408 (22%), Positives = 169/408 (41%), Gaps = 84/408 (20%)
Query: 392 QYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKS 451
Q LQ Y E Q + K+ LE LK + + +S Q ++ Q+K L E+ +
Sbjct: 1060 QNLQKYQAECSQFKAKLASLEE----LKRQAE---LDGKSAKQNLDKCYGQIKELNEKIT 1112
Query: 452 TIQSKLSKTEEYSKECLKEFKKIISKYNVLQ----------GQNKTLEEKNI-QLSLEKQ 500
+ ++ + K F + + Y+ LQ G K EK I + E +
Sbjct: 1113 RLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIE 1172
Query: 501 QMMEALDQLKSKEHKTQSDMAIVNNE--------NNRMSIEMEAMKTNILLIQDEKEMLE 552
++ L + +++ + ++++A V N N+ E+ KT I I +KE
Sbjct: 1173 RLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDS 1232
Query: 553 KKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQ 612
K L S +LK+ EI++L + I++ + + E LQ
Sbjct: 1233 KNLRNQLDRLSRENRDLKD---EIVRLND-------------SILQATEQRRRAEENALQ 1276
Query: 613 ESTAARQIMER----EIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLS 668
+ +IM++ EIE Q Q +E+N + +K SL E +
Sbjct: 1277 QKACGSEIMQKKQHLEIELKQVMQQRSEDN------------ARHKQSLEE-------AA 1317
Query: 669 KMVMETKTDNQILKEELKKHSQENIKFENSISRL----TEDKILLEN------------- 711
K + + + + LK E ++ ++ ++EN +S++ E+ I L+N
Sbjct: 1318 KTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTI 1377
Query: 712 YVRSIENERDTLEF--EMRHLQREYLSLSDKICNQHNDPSKTTYISRR 757
+ +++ E DT + ++ +L RE SLS++I N ++TT RR
Sbjct: 1378 HQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRR 1425
Score = 56.2 bits (134), Expect = 1e-07
Identities = 84/408 (20%), Positives = 182/408 (44%), Gaps = 78/408 (19%)
Query: 202 DDICHSIKQMKEELQKSH----DGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFI 257
+D C K+++EEL+ + + +TN Q L+ V + + D+
Sbjct: 1586 EDSCKR-KKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQ--------- 1635
Query: 258 KEENLDGNLNEDIKSKR-----ISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMH 312
+ + LDG+L E +++ SE+EAL ++LL +E+V + H+
Sbjct: 1636 QRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHL--------------- 1680
Query: 313 RGKKNEKNNKEIPITGKNITDLKFH-SRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSII 371
+NE K I +++ + K R+ T + + H M ++E + ++ +
Sbjct: 1681 ---RNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKE--HLMLEEELRNLRLEYDDLR 1735
Query: 372 -SENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQ 430
+E S N+ + +++Q N ++++Q + +L+ E NL+
Sbjct: 1736 RGRSEADSDKNATILELRSQLQISNN---RTLELQGLINDLQRERENLR----------- 1781
Query: 431 SLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEE 490
Q++E ++KQ +E + IQ +++ + ++E + ++ K VL+ L+
Sbjct: 1782 ---QEIEKFQKQA---LEASNRIQ----ESKNQCTQVVQERESLLVKIKVLEQDKARLQR 1831
Query: 491 KNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEM 550
+L+ K + EA ++K + + + + N+ N+ + + I I+ E+E
Sbjct: 1832 LEDELNRAKSTL-EAETRVKQR---LECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREK 1887
Query: 551 LEKKTHQLLKEKSSLGNELKESQLEIIQLKE--KERLAKTEQETLLQI 596
E +EK+SL +E++ Q EI +++E + +L + +ET Q+
Sbjct: 1888 SE-------REKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQL 1928
Score = 39.7 bits (91), Expect = 0.011
Identities = 111/615 (18%), Positives = 238/615 (38%), Gaps = 153/615 (24%)
Query: 58 VLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSL 117
V Q + FQ +L+ + + + EE L+ K EDS +EE+L G +
Sbjct: 1551 VKDQDITRFQ----NSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLK 1606
Query: 118 PQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQ 177
Q++ + NL+ + E + I+K + ++ Q
Sbjct: 1607 EQAIKI----------------TNLTQQL-----EQASIVKK---------RSEDDLRQQ 1636
Query: 178 ADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPD 237
D LD ++ +EEL++ AL +L LQ
Sbjct: 1637 RDV--------------------LDGHLREKQRTQEELRRLSSEVEALRRQL--LQEQES 1674
Query: 238 VHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHV 297
V K ++ E+ + + KS+ ++E + +++L E ++K H+
Sbjct: 1675 V--------------KQAHLRNEHFQKAIED--KSRSLNESKIEIERLQSLTENLTKEHL 1718
Query: 298 HFCRKCK--KLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVP---RYTLSFLDQTK 352
+ + +L ++ RG+ ++ KN T L+ S++ TL
Sbjct: 1719 MLEEELRNLRLEYDDLRRGRSEADSD-------KNATILELRSQLQISNNRTLELQGLIN 1771
Query: 353 HEMKDKE--RQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVME 410
+++E RQ Q + E ++++ QC +Q +ES+ ++ KV+E
Sbjct: 1772 DLQRERENLRQEIEKFQKQAL---EASNRIQESKNQCTQVVQE-----RESLLVKIKVLE 1823
Query: 411 LESENL----NLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSK----LSKTEE 462
+ L + ++ K + + Q++E ++Q++N + + T S+ + K E
Sbjct: 1824 QDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIES 1883
Query: 463 YSKECLKEFKKIISKYNVLQGQNKTLEEK------------NIQLSLEKQQMMEALDQLK 510
++ +E + S+ LQ + K +EE+ QL E+ + +D+L+
Sbjct: 1884 EREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLR 1943
Query: 511 S------KEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQ-DEKEMLEKKT-HQLLKEK 562
+E +T+ + + + + + ++ + +Q E ++++K T +LLK K
Sbjct: 1944 QRPYGSHRETQTECEWTV-----DTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGK 1998
Query: 563 SSLGNELKESQ-------------------LEIIQLKEKERLAKTEQETLLQ-------I 596
S+ E Q +++ K K+ ++ LL+ I
Sbjct: 1999 KSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGI 2058
Query: 597 IETVKDEKLNLETTL 611
I+ ++EKL +++ +
Sbjct: 2059 IDPHRNEKLTVDSAI 2073
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 81.3 bits (199), Expect = 3e-15
Identities = 133/586 (22%), Positives = 236/586 (40%), Gaps = 62/586 (10%)
Query: 182 ILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHR- 240
+++K K + L FC ++ ++ +KE+ QK E++ NE T +D + +
Sbjct: 400 VIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQK----EISELNE--TFLSDSEKEKL 453
Query: 241 NGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFC 300
+++ + + N +++E + LN + + E+ +++ L E+ K F
Sbjct: 454 TLMFEIQGLKEQCEN-LQQEKQEAILNYE----SLREIMEILQTELG--ESAGKISQEF- 505
Query: 301 RKCKKLSKSEMHR---------GKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQT 351
K+ S++H +K+ + G+N L VP L+ T
Sbjct: 506 ESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPE-----LENT 560
Query: 352 KHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMEL 411
+++K L E K+NS+TE+ I L+N +E KK
Sbjct: 561 IKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCERE 620
Query: 412 ESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEF 471
E L L K++ I L QKV L+ ++EK KL K + +
Sbjct: 621 ERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEK-------LMVQM 673
Query: 472 KKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMS 531
K + VL + K+L E+N +LS EK+Q+ L+ S++ I E
Sbjct: 674 KVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQL 733
Query: 532 IEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQE 591
+ E N LL ++ + L KT QL +G+E+ E E K+ + + E
Sbjct: 734 MVEEQDNLNKLLENEQVQKLFVKT-QLYGFLKEMGSEVSEDSEE----KDVVNVLQAVGE 788
Query: 592 TLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEAS 651
+L +I +EK NL E +E+EI+ +Q E +++ + E
Sbjct: 789 SLAKI----NEEKCNLAFQRDEKVLE---LEKEIKCLQEESVVQCEELKSLLRDYEQEKV 841
Query: 652 IYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLEN 711
+ + L EI E E L ++E K N+ + E +N+ + T K + N
Sbjct: 842 LLRKELEEIQSEKEALQSDLLEMKNANEKTRLE-----NQNLLIQVEEVSQTCSKSEIHN 896
Query: 712 -----YVRSIENERDTLE-FEMRHLQREYLSLSDKICNQ---HNDP 748
+++ EN + LE E+R + E + L D + NDP
Sbjct: 897 EKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDP 942
Score = 80.5 bits (197), Expect = 6e-15
Identities = 139/672 (20%), Positives = 278/672 (41%), Gaps = 97/672 (14%)
Query: 85 EENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHS---EDTLTLRTST-D 140
+E LS E +E++ L S +++LS D L Q +V + H E L L D
Sbjct: 680 KEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQD 739
Query: 141 NLSSNIIIHPSENSDILKNY--NNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFC 198
NL+ + EN + K + Y FL V ++ +K + V
Sbjct: 740 NLNKLL-----ENEQVQKLFVKTQLYGFLKEMGSEVSEDSE----EKDVVNV-------- 782
Query: 199 ENLDDICHSIKQMKEE---LQKSHDGEVA-LTNELQTLQTDPDVH-RNGKYDMSPIHQDK 253
L + S+ ++ EE L D +V L E++ LQ + V K + Q+K
Sbjct: 783 --LQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEK 840
Query: 254 MNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFH-------VHFCRKCKKL 306
+ KE E+I+S++ EAL LL + K + +
Sbjct: 841 VLLRKEL-------EEIQSEK----EALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTC 889
Query: 307 SKSEMHRGKKN----EKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQP 362
SKSE+H K+ E N + + K + D + + + +L+ K++ ++
Sbjct: 890 SKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKEL 949
Query: 363 FLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKM 422
+ EK K+N + V + L + KE+ +++++ L SE L + M
Sbjct: 950 EEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASM 1009
Query: 423 KPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECL----------KEFK 472
+ LI +S + YEKQ + L EK + + E+ +++ + +
Sbjct: 1010 RDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNE 1069
Query: 473 KIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSI 532
++++ LQ K LE + +++ K + + L+ K ++ + + A NE + +
Sbjct: 1070 DLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQV 1129
Query: 533 EMEAMKTNILLIQDEKEMLEKKTHQ-------------LLKEKSSLGNELKESQLEIIQL 579
+++ K + E E+++K Q L+KE L +L +I L
Sbjct: 1130 QLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKE---LNQKLTNKNNKIEDL 1186
Query: 580 KEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIM-EREIENIQTYQSTAEEN 638
+++ ++ K +QETL + I +++ E +++T +Q++ + + E + Q+ +
Sbjct: 1187 EQEIKIQKQKQETLQEEITSLQSSVQQYE---EKNTKIKQLLVKTKKELADSKQAETDHL 1243
Query: 639 FLQ-----EIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENI 693
LQ E++ ++ + +YK L+EI E + ++ LK ++H +
Sbjct: 1244 ILQASLKGELEASQQQVEVYKIQLAEITSEKHKI----------HEHLKTSAEQHQRTLS 1293
Query: 694 KFENSISRLTED 705
++ ++ L E+
Sbjct: 1294 AYQQRVTALQEE 1305
Score = 77.4 bits (189), Expect = 5e-14
Identities = 118/556 (21%), Positives = 242/556 (43%), Gaps = 64/556 (11%)
Query: 193 LKHGFCENLDDICHSIKQMK---EELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPI 249
L+ F E D + ++ +++ E+L + L N ++ LQ +NG Y +S
Sbjct: 523 LRTAFTEK-DALLETVNRLQGENEKLLSQQELVPELENTIKNLQ-----EKNGVYLLSLS 576
Query: 250 HQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKS 309
+D M +KE L+G +N + K + + KL E + FH +KC++ +
Sbjct: 577 QRDTM--LKE--LEGKINSLTEEK-----DDFINKLKNSHEEMDNFH----KKCEREERL 623
Query: 310 EMHRGKKNEKN---NKEIP-----ITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQ 361
+ GKK E+ N E+ +TG LK + + + Q K +DKE
Sbjct: 624 ILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKE-- 681
Query: 362 PFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNY-----LKESV-QIQKKV--MELES 413
V + S E+ +K++S +Q ++ + LKE + Q++KK+ M E
Sbjct: 682 ---VLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQ 738
Query: 414 ENLN--LKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEF 471
+NLN L+++ +F L ++ ++ EEK + + E +K + E
Sbjct: 739 DNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAK--INEE 796
Query: 472 KKIISKYNVLQGQNKTLE-EKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRM 530
K ++ Q K LE EK I+ L+++ +++ ++LKS + + ++ E +
Sbjct: 797 KCNLA----FQRDEKVLELEKEIKC-LQEESVVQC-EELKSLLRDYEQEKVLLRKELEEI 850
Query: 531 SIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQ 590
E EA+++++L +++ E + LL + + +S++ EKE+ E
Sbjct: 851 QSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIH----NEKEKCFIKEH 906
Query: 591 ETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEA 650
E L ++E + E L + + A+ +++ ++ + ++I+N + E
Sbjct: 907 ENLKPLLEQKELRDRRAELILLKDSLAKS------PSVKNDPLSSVKELEEKIENLEKEC 960
Query: 651 SIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLE 710
+ +++I K + ++ + Q +KEEL+ E + S+ L + +
Sbjct: 961 KEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYK 1020
Query: 711 NYVRSIENERDTLEFE 726
N + E + + L+ E
Sbjct: 1021 NLLLEYEKQSEQLDVE 1036
Score = 64.7 bits (156), Expect = 3e-10
Identities = 131/755 (17%), Positives = 307/755 (40%), Gaps = 88/755 (11%)
Query: 23 ILNSSEGVKESGCSDTEYGC---IAESENQIQPQSALKVLQQQLESFQALRMQTLQNVSM 79
++N + V ES E C E ++ + +K LQ++ ++ + L+ S+
Sbjct: 779 VVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEE----SVVQCEELK--SL 832
Query: 80 PTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTST 139
+ ++E + + K + + + S +E L D + ++ N +++ +++ L
Sbjct: 833 LRDYEQEKVLLRK-----ELEEIQSEKEALQSDLLEM--KNANEKTRLENQNLLIQVEEV 885
Query: 140 DNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCE 199
S IH + +K + N L +A+ ++L S P +K+
Sbjct: 886 SQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDR-RAELILLKDSLAKSPSVKNDPLS 944
Query: 200 NLDDICHSI----KQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMN 255
++ ++ I K+ KE+ +K + ++ + L + + K ++ + +K
Sbjct: 945 SVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEK-- 1002
Query: 256 FIKEENLDGNLNEDIKSKR-----ISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSE 310
+ L ++ + I+ + E E ++L +E + F ++L S
Sbjct: 1003 ----DQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNST 1058
Query: 311 MHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSI 370
+ N N + I L+ ++++ + + + K M DKE + +++
Sbjct: 1059 LQCETINSDNEDLLA----RIETLQSNAKLLEVQILEVQRAK-AMVDKELEAEKLQKEQK 1113
Query: 371 ISENEKT-SKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNL---KSKMKPLI 426
I E+ T +++ + Q + + LQ ++E ++K + N+ + + MK L
Sbjct: 1114 IKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELN 1173
Query: 427 FTTQSLIQKVETYEKQLK-------NLVEEKSTIQSKLSKTEEYS----------KECLK 469
+ K+E E+++K L EE +++QS + + EE + K+ L
Sbjct: 1174 QKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELA 1233
Query: 470 EFKKIISKYNVLQGQNK-TLEEKNIQLSLEKQQMMEALDQ-------LKSKEHKTQSDMA 521
+ K+ + + +LQ K LE Q+ + K Q+ E + LK+ + Q ++
Sbjct: 1234 DSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLS 1293
Query: 522 IVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSL--------GNELKESQ 573
+ E A K + E E + + H +LK++ + G + +
Sbjct: 1294 AYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREH 1353
Query: 574 LEII--QLKEKERLAKTEQETLLQIIETVKDEKLNL----ETTLQESTAARQIMEREIEN 627
LE++ QLK K + ++ + + ++T++ E L LQE+ + + ++ +
Sbjct: 1354 LEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCS 1413
Query: 628 IQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKK 687
IQ+ + Q + S+ + +NS + + + + +ET L+++L K
Sbjct: 1414 IQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVET------LQQQLSK 1467
Query: 688 HSQENIKFENSISRLTEDKILLENYVRSIENERDT 722
+ + +N + T + + ++++ R+T
Sbjct: 1468 MEAQLFQLKNEPT--TRSPVSSQQSLKNLRERRNT 1500
Score = 59.3 bits (142), Expect = 1e-08
Identities = 85/419 (20%), Positives = 187/419 (44%), Gaps = 50/419 (11%)
Query: 348 LDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKK 407
LD E + E+Q +K+ +I + E V + + Q NY+KE ++ +
Sbjct: 78 LDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNE 137
Query: 408 VMELES----ENLNLKSKMKPLIFTTQSLIQKVE---TYEKQLKNLVEEKSTI------- 453
+M + S + NL+ +++ + T L ++++ E +K L EE I
Sbjct: 138 LMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQ 197
Query: 454 ----QSKLSKTEEYSKECLKEFKKIISKYNVLQGQN-KTLEEKNIQL-SLEKQQMMEALD 507
Q +L T + KE + + + II + +N +L+E+ +QL ++ ++++ E +
Sbjct: 198 ILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMC 257
Query: 508 QLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGN 567
Q+++ + ++++ +N + + EA EK + +K +L + + N
Sbjct: 258 QIEASAKEHEAEINKLNELKENLVKQCEA---------SEKNIQKKYECELENLRKATSN 308
Query: 568 ELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKL-NLETTLQESTAARQIMEREI- 625
+++Q+ I L+E +E V +EK+ +LE TL+E + I++ E+
Sbjct: 309 ANQDNQICSILLQEN------------TFVEQVVNEKVKHLEDTLKELESQHSILKDEVT 356
Query: 626 --ENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECE--MLSKMVMETKTDNQIL 681
N++ ++ E + + + N L + KE + ++ K+ E N+
Sbjct: 357 YMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELL-LAKEEQGCVIEKLKSELAGLNKQF 415
Query: 682 KEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDK 740
+++H++E + + E L E ++ E E+ TL FE++ L+ + +L +
Sbjct: 416 CYTVEQHNREVQSLKEQHQK--EISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQE 472
Score = 46.2 bits (108), Expect = 1e-04
Identities = 80/380 (21%), Positives = 164/380 (43%), Gaps = 67/380 (17%)
Query: 435 KVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQ 494
K+ET K+ +L++ + K + E KE +++ SK V +G ++
Sbjct: 21 KLETLPKE--DLIKFAKKQMMLIQKAKSRCTELEKEIEELRSK-PVTEGTGDIIKA---- 73
Query: 495 LSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEM---- 550
+ E LD L ++ +T+ + EN +M E+E T + E E
Sbjct: 74 -------LTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHIN 126
Query: 551 ----LEKKTHQLL-------KEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIET 599
+E ++L+ ++K++L +L+E+ ++L E+ + ++ + ++ E
Sbjct: 127 YVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEE 186
Query: 600 V-------KDEKLNLETTLQESTAARQIMEREIENI-----QTYQ---STAEENFLQ--- 641
+ +++ L L+ L +T ++ +++NI Q YQ ++ +E LQ
Sbjct: 187 IEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKA 246
Query: 642 ----EIKN--AKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKF 695
E+K + EAS K +EI K E+ +V + + + ++ KK+ E
Sbjct: 247 IHQEEVKELMCQIEASA-KEHEAEINKLNELKENLVKQCEASEKNIQ---KKYECELENL 302
Query: 696 ENSISRLTEDK-----ILLEN-YVRSIENER-DTLEFEMRHLQREYLSLSDKICNQHNDP 748
+ S +D +L EN +V + NE+ LE ++ L+ ++ L D++ +N
Sbjct: 303 RKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLK 362
Query: 749 SKTTYISRREKFHFDNYTHE 768
K ++ K D + HE
Sbjct: 363 LKLEMDAQHIK---DEFFHE 379
Score = 43.1 bits (100), Expect = 0.001
Identities = 57/266 (21%), Positives = 117/266 (43%), Gaps = 35/266 (13%)
Query: 350 QTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQY----------LQNYLK 399
+T+ +++E L+ Q I ++ + + +V+E + ++ LQ +
Sbjct: 1343 ETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVS 1402
Query: 400 ESVQIQKKVMELESENLNLKSKMKPLI--FTTQSLIQKVETYEKQLKNLVEEK----STI 453
+ ++++K+ ++SEN+ +KS+ + T+Q+ + + ++ Q+++L EE T+
Sbjct: 1403 KEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLR-NSFRDQVRHLQEEHRKTVETL 1461
Query: 454 QSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSL--------EKQQMMEA 505
Q +LSK E + LK S + Q E +N L L E+ + ME
Sbjct: 1462 QQQLSKMEAQLFQ-LKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMET 1520
Query: 506 LD--QLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKS 563
D + S TQS ++N+ ++ + + + KE L +K K
Sbjct: 1521 TDTESVSSASTYTQSLEQLLNSPETKL-------EPPLWHAEFTKEELVQKLSSTTKSAD 1573
Query: 564 SLGNELKESQLEIIQLKEKERLAKTE 589
L L+E++ L E+ +L K+E
Sbjct: 1574 HLNGLLRETEATNAILMEQIKLLKSE 1599
Score = 31.2 bits (69), Expect = 4.0
Identities = 67/330 (20%), Positives = 142/330 (43%), Gaps = 29/330 (8%)
Query: 208 IKQMKEELQKSHDGEVALTNELQTLQTDPD--VHRNGKYDMSPIH-----QDKMNFIKEE 260
I Q+K +LQ S + +ELQTLQ++ D + R+ K + ++K+ I+ E
Sbjct: 1358 IDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSE 1417
Query: 261 NLDGNLNEDIKSKRISELEALVKKLL-PFRETVSKFHVHFCRKC----KKLSKSEMHRGK 315
N+ + + ++ +S+L + + L FR+ V + ++LSK E +
Sbjct: 1418 NM---MMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQ 1474
Query: 316 -KNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISEN 374
KNE + + +++ +L+ L T+ E + E S+ S +
Sbjct: 1475 LKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGME----TTDTESVSSAS 1530
Query: 375 EKTSKVNSVTEQCVAKIQ---YLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQS 431
T + + K++ + + KE + +QK +S + +L ++ T
Sbjct: 1531 TYTQSLEQLLNSPETKLEPPLWHAEFTKEEL-VQKLSSTTKSAD-HLNGLLRETEATNAI 1588
Query: 432 LIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEK 491
L+++++ + +++ L E++ + K + EY K L +F I K + + +
Sbjct: 1589 LMEQIKLLKSEIRRL--ERNQEREKSAANLEYLKNVLLQF--IFLKPGSERERLLPVINT 1644
Query: 492 NIQLSLEKQQMMEALDQLKSKEHKTQSDMA 521
+QLS E++ + A+ Q + + S A
Sbjct: 1645 MLQLSPEEKGKLAAVAQGEEENASRSSGWA 1674
>gi|217272802 hyaluronan-mediated motility receptor isoform a [Homo
sapiens]
Length = 725
Score = 81.3 bits (199), Expect = 3e-15
Identities = 109/545 (20%), Positives = 238/545 (43%), Gaps = 60/545 (11%)
Query: 209 KQMKEELQKSHDGEV-ALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLN 267
K+ K+ L D + A ++++ ++ + +N K D+ + ++ ++E
Sbjct: 48 KESKQNLNVDKDTTLPASARKVKSSESKKESQKNDK-DLKILEKEIRVLLQERGAQDRRI 106
Query: 268 EDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKS-EMHRGKKNEKNN-KEIP 325
+D++++ + ++EA + L + ++S + ++ +L+++ E+ + K +E N K +
Sbjct: 107 QDLETE-LEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLR 165
Query: 326 ITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVK--------QGSIISENEKT 377
I + L+ + R + Q EMK + Q L + +G ++S ++
Sbjct: 166 ILSLELMKLR-NKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEK 224
Query: 378 SKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVE 437
S TE+ ++Y++ S Q++K +++ NLK K ++ QSL + +
Sbjct: 225 IDEKSETEKL---LEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIV 281
Query: 438 TYEKQLKNLVEEKSTIQSK----LSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNI 493
KQ+++L + ++ + +++ E+++ E + + K+ + Q + + L++K +
Sbjct: 282 ILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKEL 341
Query: 494 QLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEK 553
Q+ QQ E L K Q +M EK + E+
Sbjct: 342 QIDSLLQQEKELSSSLHQKLCSFQEEMV------------------------KEKNLFEE 377
Query: 554 KTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQE 613
+ Q L E L + KE Q E + +K+ E AK+ E L + E +K ++ LE +
Sbjct: 378 ELKQTLDELDKL--QQKEEQAERL-VKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAA 434
Query: 614 STAARQIMERE-------IENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEM 666
T A +++ + +E++ + + EI++ K E S + ++ GK E
Sbjct: 435 HTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAED 494
Query: 667 LSKMVMETKTDNQ-----ILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERD 721
+ ++ T++ NQ +L + K +E E ++S L + L + E+ R
Sbjct: 495 VQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRK 554
Query: 722 TLEFE 726
LE E
Sbjct: 555 QLEDE 559
Score = 70.5 bits (171), Expect = 6e-12
Identities = 80/385 (20%), Positives = 177/385 (45%), Gaps = 28/385 (7%)
Query: 372 SENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQS 431
SE++K S+ N + + K ++ L+E +++ +LE+E +++++ + S
Sbjct: 72 SESKKESQKNDKDLKILEK--EIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTS 129
Query: 432 LIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEK 491
L T EKQL L ++SK S E +++ L+ I +++ +NK E
Sbjct: 130 LSANNATLEKQLIELTRTNELLKSKFS--ENGNQKNLR-----ILSLELMKLRNK--RET 180
Query: 492 NIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEML 551
++ + KQ+ ME Q+ + + +S I E +SIE E + DEK
Sbjct: 181 KMRGMMAKQEGMEMKLQVTQRSLE-ESQGKIAQLEGKLVSIEKEKI--------DEKSET 231
Query: 552 EKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTL 611
EK + ++E S +++++ +L+I QL+E K + + +L + +++++ + L +
Sbjct: 232 EKLL-EYIEEISCASDQVEKYKLDIAQLEEN---LKEKNDEILSLKQSLEENIVILSKQV 287
Query: 612 QESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMV 671
++ Q++E+E E+ EN E++N K + + + ++ ++ + ++
Sbjct: 288 EDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLL 347
Query: 672 METKTDNQILKEELKKHSQENIK----FENSISRLTEDKILLENYVRSIENERDTLEFEM 727
+ K + L ++L +E +K FE + + ++ L+ E LE E
Sbjct: 348 QQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEA 407
Query: 728 RHLQREYLSLSDKICNQHNDPSKTT 752
+ E L +K+ + + K++
Sbjct: 408 KSRAEELKLLEEKLKGKEAELEKSS 432
Score = 54.3 bits (129), Expect = 4e-07
Identities = 94/464 (20%), Positives = 202/464 (43%), Gaps = 50/464 (10%)
Query: 257 IKEENLD-GNLNEDIKSKR---ISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMH 312
+++ LD L E++K K +S ++L + ++ + V +V KC+ L K +
Sbjct: 248 VEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNV----KCQLLEKEKED 303
Query: 313 RGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIIS 372
+N ++N+ + +N+ ++ L ++ K + K+ + L ++ + S
Sbjct: 304 HVNRNREHNENLNAEMQNLKQ--------KFILEQQEREKLQQKELQIDSLLQQEKELSS 355
Query: 373 ENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSL 432
+ K+ S E+ V + + LK+++ K+ + E + L +K L +S
Sbjct: 356 SLHQ--KLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERL---VKQLEEEAKSR 410
Query: 433 IQKVETYEKQLKNLVEE--KSTI---QSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKT 487
++++ E++LK E KS+ Q+ L E+Y ++ + + +++ K
Sbjct: 411 AEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDS-MVQSLEDVTAQFE----SYKA 465
Query: 488 LEEKNIQ-LSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQD 546
L I+ L LE + E + Q + + N + ++T L +
Sbjct: 466 LTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKET 525
Query: 547 EKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQE-TLLQIIETVKDEKL 605
E +++ T L++ + L N+LK+ + + + E E K E+E T ++ E + +L
Sbjct: 526 E---IKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRL 582
Query: 606 NLETTLQESTAARQI----MEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIG 661
L L T Q+ E E + + A+E L +I+++ ++ ++N +I
Sbjct: 583 -LYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQ-LNKIRDSYAKLLGHQNLKQKI- 639
Query: 662 KECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTED 705
K V++ K +N LK E+ K + K + S ++L E+
Sbjct: 640 -------KHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEE 676
Score = 48.9 bits (115), Expect = 2e-05
Identities = 114/565 (20%), Positives = 217/565 (38%), Gaps = 89/565 (15%)
Query: 41 GCIAESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSK 100
G +A+ E + L+V Q+ LE Q ++ L+ + E ++ + EKS E K
Sbjct: 184 GMMAKQEGM---EMKLQVTQRSLEESQG-KIAQLEGKLVSIEKEKID---EKS---ETEK 233
Query: 101 TLHSVEE-KLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKN 159
L +EE + D V + + E + + +L NI+I + D+
Sbjct: 234 LLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDL--- 290
Query: 160 YNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQM----KEEL 215
NV Q +L+K K ENL+ ++KQ ++E
Sbjct: 291 -------------NVKCQ----LLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQER 333
Query: 216 QKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRI 275
+K E+ + + LQ K S +HQ +F +E + NL E+ + +
Sbjct: 334 EKLQQKELQIDSLLQ----------QEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTL 383
Query: 276 SELEALVKKLLPFRETVSKFHVHFCRKCKKLS-KSEMHRGKKNEKNNKEIPITGKNITDL 334
EL+ L +K V + + ++L E +GK+ E
Sbjct: 384 DELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAA--------- 434
Query: 335 KFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYL 394
H++ D ++D Q F + SE E NS ++ AK
Sbjct: 435 --HTQATLLLQEKYDSMVQSLEDVTAQ-FESYKALTASEIEDLKLENSSLQEKAAKAG-- 489
Query: 395 QNYLKESVQIQKKVMELESEN---------LNLKSKMK--PLIFTTQSLIQKVETYEKQL 443
K + +Q +++ ES N L KS +K + T S +QK+ + QL
Sbjct: 490 ----KNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQL 545
Query: 444 KNLVE----EKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEK 499
K E + + + ++ E + E +E K Y L + K + + +EK
Sbjct: 546 KQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEK 605
Query: 500 QQMMEALDQLKSKEHKTQSDMA-IVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQL 558
Q ++ + + +K + A ++ ++N + I+ +++ ++DE L+ + +L
Sbjct: 606 QALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIK------HVVKLKDENSQLKSEVSKL 659
Query: 559 ---LKEKSSLGNELKESQLEIIQLK 580
L +K +L+E +++ +K
Sbjct: 660 RCQLAKKKQSETKLQEELNKVLGIK 684
>gi|217272804 hyaluronan-mediated motility receptor isoform d [Homo
sapiens]
Length = 638
Score = 80.9 bits (198), Expect = 4e-15
Identities = 102/491 (20%), Positives = 221/491 (45%), Gaps = 37/491 (7%)
Query: 257 IKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKS-EMHRGK 315
++E +D++++ + ++EA + L + ++S + ++ +L+++ E+ + K
Sbjct: 9 LQERGAQDRRIQDLETE-LEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSK 67
Query: 316 KNEKNN-KEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVK-------- 366
+E N K + I + L+ + R + Q EMK + Q L +
Sbjct: 68 FSENGNQKNLRILSLELMKLR-NKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQL 126
Query: 367 QGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLI 426
+G ++S ++ S TE+ ++Y++ S Q++K +++ NLK K ++
Sbjct: 127 EGKLVSIEKEKIDEKSETEKL---LEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEIL 183
Query: 427 FTTQSLIQKVETYEKQLKNLVEEKSTIQSK----LSKTEEYSKECLKEFKKIISKYNVLQ 482
QSL + + KQ+++L + ++ + +++ E+++ E + + K+ + Q
Sbjct: 184 SLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQ 243
Query: 483 GQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNIL 542
+ + L++K +Q+ QQ E L K Q +M E N E++ +
Sbjct: 244 QEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMV---KEKNLFEEELKQTLDELD 300
Query: 543 LIQDEKEMLEKKTHQLLKEKSSLGNELK--ESQLEIIQLK-EKERLAKTEQETLLQIIET 599
+Q ++E E+ QL +E S ELK E +L+ + + EK A T+ LLQ E
Sbjct: 301 KLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQ--EK 358
Query: 600 VKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSE 659
+LE + + + + EIE+++ S+ +E + KNA+ ++ +
Sbjct: 359 YDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAED----VQHQILA 414
Query: 660 IGKECEMLSKMVMETKTDNQILKEELKKHS----QENIKFENSISRLTED--KILLENYV 713
+ +M+++ +T + + + E+K+ + Q+ +N + + ED K L +
Sbjct: 415 TESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEG 474
Query: 714 RSIENERDTLE 724
R E E T E
Sbjct: 475 RKAEKENTTAE 485
Score = 67.8 bits (164), Expect = 4e-11
Identities = 74/359 (20%), Positives = 164/359 (45%), Gaps = 26/359 (7%)
Query: 398 LKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKL 457
L+E +++ +LE+E +++++ + SL T EKQL L ++SK
Sbjct: 9 LQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKF 68
Query: 458 SKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQ 517
S E +++ L+ I +++ +NK E ++ + KQ+ ME Q+ + + +
Sbjct: 69 S--ENGNQKNLR-----ILSLELMKLRNK--RETKMRGMMAKQEGMEMKLQVTQRSLE-E 118
Query: 518 SDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEII 577
S I E +SIE E + DEK EK + ++E S +++++ +L+I
Sbjct: 119 SQGKIAQLEGKLVSIEKEKI--------DEKSETEKLL-EYIEEISCASDQVEKYKLDIA 169
Query: 578 QLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEE 637
QL+E K + + +L + +++++ + L +++ Q++E+E E+ E
Sbjct: 170 QLEEN---LKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNE 226
Query: 638 NFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIK--- 694
N E++N K + + + ++ ++ + ++ + K + L ++L +E +K
Sbjct: 227 NLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKN 286
Query: 695 -FENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTT 752
FE + + ++ L+ E LE E + E L +K+ + + K++
Sbjct: 287 LFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSS 345
Score = 48.9 bits (115), Expect = 2e-05
Identities = 114/565 (20%), Positives = 217/565 (38%), Gaps = 89/565 (15%)
Query: 41 GCIAESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSK 100
G +A+ E + L+V Q+ LE Q ++ L+ + E ++ + EKS E K
Sbjct: 97 GMMAKQEGM---EMKLQVTQRSLEESQG-KIAQLEGKLVSIEKEKID---EKS---ETEK 146
Query: 101 TLHSVEE-KLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKN 159
L +EE + D V + + E + + +L NI+I + D+
Sbjct: 147 LLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDL--- 203
Query: 160 YNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQM----KEEL 215
NV Q +L+K K ENL+ ++KQ ++E
Sbjct: 204 -------------NVKCQ----LLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQER 246
Query: 216 QKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRI 275
+K E+ + + LQ K S +HQ +F +E + NL E+ + +
Sbjct: 247 EKLQQKELQIDSLLQ----------QEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTL 296
Query: 276 SELEALVKKLLPFRETVSKFHVHFCRKCKKLS-KSEMHRGKKNEKNNKEIPITGKNITDL 334
EL+ L +K V + + ++L E +GK+ E
Sbjct: 297 DELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAA--------- 347
Query: 335 KFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYL 394
H++ D ++D Q F + SE E NS ++ AK
Sbjct: 348 --HTQATLLLQEKYDSMVQSLEDVTAQ-FESYKALTASEIEDLKLENSSLQEKAAKAG-- 402
Query: 395 QNYLKESVQIQKKVMELESEN---------LNLKSKMK--PLIFTTQSLIQKVETYEKQL 443
K + +Q +++ ES N L KS +K + T S +QK+ + QL
Sbjct: 403 ----KNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQL 458
Query: 444 KNLVE----EKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEK 499
K E + + + ++ E + E +E K Y L + K + + +EK
Sbjct: 459 KQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEK 518
Query: 500 QQMMEALDQLKSKEHKTQSDMA-IVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQL 558
Q ++ + + +K + A ++ ++N + I+ +++ ++DE L+ + +L
Sbjct: 519 QALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIK------HVVKLKDENSQLKSEVSKL 572
Query: 559 ---LKEKSSLGNELKESQLEIIQLK 580
L +K +L+E +++ +K
Sbjct: 573 RCQLAKKKQSETKLQEELNKVLGIK 597
>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
Length = 2479
Score = 80.5 bits (197), Expect = 6e-15
Identities = 163/809 (20%), Positives = 333/809 (41%), Gaps = 127/809 (15%)
Query: 6 QHREEDEVDSVLLSASKI---LNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQQ 62
Q EDEV V + L+ S+ KES C +E E+ N P + ++ L ++
Sbjct: 1673 QENHEDEVKKVKAEVEDLKYLLDQSQ--KESQCLKSELQAQKEA-NSRAPTTTMRNLVER 1729
Query: 63 LESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVN 122
L+S AL+ E Q++ LS T + E +S S +V
Sbjct: 1730 LKSQLALK-----------EKQQKALSRALLE-LRAEMTAAAEERIISATSQKEAHLNVQ 1777
Query: 123 VPSQIHSEDTLTLRTSTDNLSSNII-----IHPSEN-----SDILKNYNNFYRFLPTAPP 172
QI T L+T ++L+ N++ + S+N +D L + NN + A
Sbjct: 1778 ---QIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYN 1834
Query: 173 NVMSQADTVIL--DKSKITVPFLKHGF-----CENLDDICHSIKQMKEELQKSHDGEVAL 225
++ + + + D+ K + L G +N + +++ ++L+ +G+V
Sbjct: 1835 KILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKV-- 1892
Query: 226 TNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKL 285
+ + P +N K ++ + K K E + L E + E+ L K+L
Sbjct: 1893 ----EEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKE-----KEGEVFTLTKQL 1943
Query: 286 LPFRETVSKFHVHFCRKCKKLSKSEMH-------RGKKNEKNNKEIPITGKNITD----L 334
++ +K +KL + M R ++EK +E+ ++ + +
Sbjct: 1944 NTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYM 2003
Query: 335 KFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYL 394
+ H +PR D ++ + R +L ++ + EK ++ ++ ++ I+
Sbjct: 2004 RAHQALPR------DSVVEDLHLQNR--YLQEK---LHALEKQFSKDTYSKPSISGIES- 2051
Query: 395 QNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQ 454
++ + ++QK+ ++L SEN+ LK +++ L +V ++ + L +EK+ +Q
Sbjct: 2052 DDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQ 2111
Query: 455 SKLS--KTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSK 512
KL + S + + E +K I G K + EK + E +Q+ +A L S+
Sbjct: 2112 RKLGHVRGSGRSGKTIPELEKTI-------GLMKKVVEK---VQRENEQLKKASGILTSE 2161
Query: 513 EHKTQSDMAIVNNENNRMSIEMEAMKTNI-LLIQDEKEMLEKKTHQLLKEKSSLGNELK- 570
+ MA + EN ++ E+E +K ++ + E K T +++ E L ELK
Sbjct: 2162 K------MANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKK 2215
Query: 571 -----------ESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQ 619
++ LEI+ K +L +T + LQ E+ + ++ +S +
Sbjct: 2216 ETDAAEKLRIAKNNLEILNEKMTVQLEETGKR--LQFAESRGPQLEGADSKSWKSIVVTR 2273
Query: 620 IMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEM---LSKMVMETKT 676
+ E +++ ++T + + ++K EA+ + +++ ++ E + K V E
Sbjct: 2274 MYETKLKELET-DIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAE 2332
Query: 677 DNQILKEELKK----------------HSQENIKFENSISRLTEDKILLENYVRSIENER 720
Q LK EL+ H E K ++ D L+ ++ +E +
Sbjct: 2333 TEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQL 2392
Query: 721 DTLEFEMRHLQREYLSLSDKICNQHNDPS 749
+ E +HL+ E L ++ ++ DPS
Sbjct: 2393 KMSDLEKQHLKEEIKKLKKEL--ENFDPS 2419
Score = 66.2 bits (160), Expect = 1e-10
Identities = 103/548 (18%), Positives = 232/548 (42%), Gaps = 93/548 (16%)
Query: 227 NELQTLQTDPD-------VHRNGKYDMSPIHQDKMNFIKEENLDG--NLNEDIKSKRISE 277
N + ++ DPD + N +S + +++ K+EN+ + + + + E
Sbjct: 6 NWKEIMKVDPDDLPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQE 65
Query: 278 LEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFH 337
+E ++++ E +KF K KL +N E+ D +F
Sbjct: 66 VELALEEVEKAGEEQAKFENQLKTKVMKL------------ENELEMAQQSAGGRDTRFL 113
Query: 338 SRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNY 397
L+Q E++D E+ E EK KVN EQ + + +N
Sbjct: 114 RNEICQLEKQLEQKDRELEDMEK------------ELEKEKKVN---EQLALRNEEAEN- 157
Query: 398 LKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVE-------EK 450
+ +L EN LK K + L Q + Y+KQ+ + E E
Sbjct: 158 ---------ENSKLRRENKRLKKK-------NEQLCQDIIDYQKQIDSQKETLLSRRGED 201
Query: 451 STIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSL-EKQQMMEALDQL 509
S +S+LSK + L E + + ++ QN+ + KN++ S+ E ++M + +++
Sbjct: 202 SDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEM-RKNLEESVQEMEKMTDEYNRM 260
Query: 510 KSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKE-----MLEKKTHQLLKEKSS 564
K+ H+T + + + EN+ ++++ + T++L ++E++ + K + SS
Sbjct: 261 KAIVHQTDNVIDQLKKENDHYQLQVQEL-TDLLKSKNEEDDPIMVAVNAKVEEWKLILSS 319
Query: 565 LGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMERE 624
+E+ E Q + L+EK + A+ + + K + L+ +QE + +++ +
Sbjct: 320 KDDEIIEYQQMLHNLREKLKNAQLDAD---------KSNVMALQQGIQERDSQIKMLTEQ 370
Query: 625 IENIQTYQSTAEEN--FLQEIKNA----KSEASIYKNSLSEIGKECEMLSKMVMETKTDN 678
+E Y E+N ++++KN K +++ + + +I ++L + E +
Sbjct: 371 VEQ---YTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTA 427
Query: 679 QILKEELKKHSQENIK-------FENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQ 731
++ + + ++ +E ++ +E+ + L + + ++N I+ +E + +
Sbjct: 428 ELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEIN 487
Query: 732 REYLSLSD 739
+ L +SD
Sbjct: 488 KLELKISD 495
Score = 64.3 bits (155), Expect = 4e-10
Identities = 98/478 (20%), Positives = 211/478 (44%), Gaps = 85/478 (17%)
Query: 307 SKSEMHRGKKNEKNNKEIPITGKN--ITDLK----------FHSRVPRYTLSFLDQTKHE 354
+ + HR +N+ E+ + G I+ LK +H ++ L L +
Sbjct: 1306 NSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNREL 1365
Query: 355 MKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQN----YLKESVQIQKKVM- 409
+KDKE +L +IISE E+T ++S+ E+ V + ++ + + + V +++++
Sbjct: 1366 VKDKEEIKYL---NNIISEYERT--ISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDI 1420
Query: 410 --ELESENLNLKSKMK--------PLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSK 459
++E LN K + P + L + ++ ++ ++E ++T +S K
Sbjct: 1421 FDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEK 1480
Query: 460 TEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQL--SLEKQQMMEALDQLKSKEHKTQ 517
+E KE +++ N+L ++K + E ++L + E+++++ L + K E K+
Sbjct: 1481 LKE------KESALRLAEQNILS-RDKVINELRLRLPATAEREKLIAELGR-KEMEPKSH 1532
Query: 518 SDMAIVN----NENNRMSIEMEAMKTNILLIQ----DEKEMLEKKTHQL--------LKE 561
+ I + N R++ + E +K L++ +++E+++K L L+
Sbjct: 1533 HTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQA 1592
Query: 562 KSSLG-------NELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQES 614
SSL + +K+S + K RLA+ EQ T+ + +++ + L+ Q+
Sbjct: 1593 DSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQ-TVAEQDDSLSSLLVKLKKVSQDL 1651
Query: 615 TAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMET 674
R+I E +++ + + +EN E+K K+E E L ++ ++
Sbjct: 1652 ERQREITELKVKEFENIKLQLQENHEDEVKKVKAEV--------------EDLKYLLDQS 1697
Query: 675 KTDNQILKEELKKHSQENIK-----FENSISRLTEDKILLENYVRSIENERDTLEFEM 727
+ ++Q LK EL+ + N + N + RL L E +++ L EM
Sbjct: 1698 QKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEM 1755
Score = 59.3 bits (142), Expect = 1e-08
Identities = 145/775 (18%), Positives = 297/775 (38%), Gaps = 145/775 (18%)
Query: 44 AESENQIQPQSALKVLQQQLESFQAL--RMQTLQNVSMPTENQEENLSMEKSHHFEDSKT 101
A + ++Q Q K L++ ++ + + ++ + T+N + L E H+
Sbjct: 228 ANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHY------ 281
Query: 102 LHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYN 161
+L + L +S N ED + + +I S++ +I++
Sbjct: 282 ------QLQVQELTDLLKSKN------EEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQ 329
Query: 162 NFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDI---CHSIKQMKEELQKS 218
+ N+ + LD K V L+ G E I ++Q +E++K+
Sbjct: 330 MLH--------NLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKN 381
Query: 219 HDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISEL 278
L NELQ + + + + KE L E ++ EL
Sbjct: 382 TCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKEL 441
Query: 279 EALVKKLLPFRETVSKFH--VHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKF 336
+K+L + V V + CK K ++EI I K I L+
Sbjct: 442 VEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIR----------DREIEILTKEINKLEL 491
Query: 337 HSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQN 396
FLD+ + + +P + +TE +K Q
Sbjct: 492 KIS------DFLDENEALRERVGLEP---------------KTMIDLTEFRNSKHLKQQQ 530
Query: 397 YLKESVQIQKKVMELESENLNLKSKMKPLI-----------FTTQSL-----IQKVETYE 440
Y E+ + K++ LE E L+LK K++ + TT+ L I + +
Sbjct: 531 YRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRIS 590
Query: 441 KQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVL---QGQNKTLEEKNIQLSL 497
++ +L+ K+ +++ SK E S+E +++ + + V+ Q + K L E+N QL
Sbjct: 591 ERKLDLLSLKNMSEAQ-SKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEE 649
Query: 498 EKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEA------------MKTNILLIQ 545
+++++A+ +++ + +++ R+ +E+ +K + +
Sbjct: 650 GMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLT 709
Query: 546 DEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAK------------------ 587
E L ++ + KE + +L ++ L+I L+++ L +
Sbjct: 710 GRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGI 769
Query: 588 ---------TEQETLLQIIETV--KDEKL-NLETTLQESTAARQIMEREIENIQTYQSTA 635
++ E L+ +++ + K++KL NLE +L++ R+ I+ QS
Sbjct: 770 APSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLED-------YNRKFAVIRHQQSLL 822
Query: 636 EENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQIL------KEELKKHS 689
+ +L E + K+E+ K E K + + + ++ K N +L +E+KK
Sbjct: 823 YKEYLSEKETWKTESKTIK---EEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKIL 879
Query: 690 QENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQ 744
EN + + +K L+ Y +E ER L E + E LS+ ++C +
Sbjct: 880 AENSRKITVLQ--VNEKSLIRQYTTLVELERQ-LRKENEKQKNELLSMEAEVCEK 931
Score = 59.3 bits (142), Expect = 1e-08
Identities = 95/437 (21%), Positives = 190/437 (43%), Gaps = 56/437 (12%)
Query: 300 CRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDK- 358
C++ ++L K + +N + ++ K++ LK R + FL + K E++ K
Sbjct: 2055 CQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKL 2114
Query: 359 ERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQI--QKKVMELESENL 416
+ G I E EKT + ++ V K+Q LK++ I +K+ +E EN
Sbjct: 2115 GHVRGSGRSGKTIPELEKTI---GLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENE 2171
Query: 417 NLKSKMKPL-IFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKII 475
LK++++ L L E+ K + ++ E ++ +L K E + E L+ K +
Sbjct: 2172 KLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKK-ETDAAEKLRIAKNNL 2230
Query: 476 SKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMS-IEM 534
N + LEE +L + + QL+ + K+ + + ++ +E
Sbjct: 2231 EILN--EKMTVQLEETGKRLQFAESRG----PQLEGADSKSWKSIVVTRMYETKLKELET 2284
Query: 535 EAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQ-----------LKEKE 583
+ K N I D K+++++ T + ++K + NE E Q++I++ LK +
Sbjct: 2285 DIAKKN-QSITDLKQLVKEATER--EQKVNKYNEDLEQQIKILKHVPEGAETEQGLKREL 2341
Query: 584 RLAKT-------EQETLLQIIETVKD---------------EKL-NLETTLQESTAARQI 620
++ + E+ L+ IE KD EK+ +LET L+ S +Q
Sbjct: 2342 QVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQH 2401
Query: 621 MEREIENIQTYQSTAEENFLQEIKNAK--SEASIYKNSLSEIGKECEMLSKMVMETKTDN 678
++ EI+ ++ + +F +EI++ K + + KN L E ++ + LS+ + T
Sbjct: 2402 LKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLE--EKVKKLSEQLGVELTSP 2459
Query: 679 QILKEELKKHSQENIKF 695
EE + + + F
Sbjct: 2460 VAASEEFEDEEESPVNF 2476
Score = 58.2 bits (139), Expect = 3e-08
Identities = 120/577 (20%), Positives = 246/577 (42%), Gaps = 68/577 (11%)
Query: 215 LQKSHDGEVALTN-ELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSK 273
LQK D V+L+ EL Q + KY + +D M + NL+ E+I K
Sbjct: 949 LQKVVDNSVSLSELELANKQYN---ELTAKY-RDILQKDNMLVQRTSNLEHLECENISLK 1004
Query: 274 RISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITD 333
++E++ K+L +E + + ++ K ++S M + KK+ N+ + I+ K IT
Sbjct: 1005 E--QVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSIS-KKITM 1061
Query: 334 LKFHSRVPR----YTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVA 389
L+ R + + + +K E + F ++ K +++ +
Sbjct: 1062 LEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELET--------KFAELTKINLDAQK 1113
Query: 390 KIQYLQNYLKESVQI------QKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQL 443
Q L++ L +SV +++++ELE + LK ++ L + ++VE Q
Sbjct: 1114 VEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQ 1173
Query: 444 KNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISK---YNVLQGQNKTLEEKNIQLSLEKQ 500
++ +E +++ +L + S E K +I+K +NV ++ ++ K
Sbjct: 1174 QSRDKEVESLRMQLLDYQAQSDE-----KSLIAKLHQHNVSLQLSEATALGKLESITSKL 1228
Query: 501 QMMEALD-QLKSKEHKTQSDMAIVNNENN------RMSIEMEAMKTNILLIQDEKEMLEK 553
Q MEA + +L+ K + + + E R +I+ + + L ++E K
Sbjct: 1229 QKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSK 1288
Query: 554 KTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEK-----LNL- 607
QL +K + E+K SQ E ++ K + + + L ++I T+KD K +N
Sbjct: 1289 TMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWH 1348
Query: 608 ----ETTLQESTAARQIMEREIE------NIQTYQ---STAEENFLQEIKNAKSEASIYK 654
E LQE R++++ + E I Y+ S+ EE +Q+ K + +
Sbjct: 1349 MKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWD 1408
Query: 655 NSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFEN----SISRLTED-KILL 709
++ ++ ++ + E Q +E ++ N ++ ++ E+ +I+L
Sbjct: 1409 QREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIIL 1468
Query: 710 ENYV--RSIENERDTLEFEMRHLQREYLSLSDKICNQ 744
E +S+E + E +R ++ LS DK+ N+
Sbjct: 1469 ETRATCKSLEEKLKEKESALRLAEQNILS-RDKVINE 1504
Score = 51.2 bits (121), Expect = 4e-06
Identities = 63/304 (20%), Positives = 132/304 (43%), Gaps = 32/304 (10%)
Query: 457 LSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKT 516
L + EE + L K+ + Q + I SL K + E L+ E K
Sbjct: 18 LPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVE-KA 76
Query: 517 QSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKK-----THQLLKEKSSLGNELKE 571
+ A N+ +KT ++ +++E EM ++ T L E L +L++
Sbjct: 77 GEEQAKFENQ----------LKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQ 126
Query: 572 SQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTY 631
E+ ++++ K E L E ++E L +E+ ++ E+ ++I Y
Sbjct: 127 KDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLR---RENKRLKKKNEQLCQDIIDY 183
Query: 632 QSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKM-----VMETKTDNQILKEELK 686
Q + + + + + E S Y++ LS+ K E++ + + E ++ +E++
Sbjct: 184 QKQIDSQ-KETLLSRRGEDSDYRSQLSK--KNYELIQYLDEIQTLTEANEKIEVQNQEMR 240
Query: 687 KHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSD--KICNQ 744
K+ +E+++ + ++T++ ++ V +N D L+ E H Q + L+D K N+
Sbjct: 241 KNLEESVQ---EMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNE 297
Query: 745 HNDP 748
+DP
Sbjct: 298 EDDP 301
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 80.5 bits (197), Expect = 6e-15
Identities = 88/402 (21%), Positives = 174/402 (43%), Gaps = 33/402 (8%)
Query: 348 LDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKK 407
L Q +E K+ +K+GS +++ KVN V E KIQ L++ S Q +
Sbjct: 546 LTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFE----KIQTLKSRAAGSAQGNNQ 601
Query: 408 VMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKEC 467
SE +L + L L ++++ K +N+ EE+ +++ L + E
Sbjct: 602 ACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEK 661
Query: 468 LKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQ----MMEALDQLKSKEHKTQSDMAIV 523
++E + + +G+ + E+ Q+ +E++Q + + DQL + S
Sbjct: 662 VEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSE 721
Query: 524 NNENNRMSIEMEAMKTNI--LLI--QDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQL 579
+ E + E+ K ++ LLI ++++++L K+ +L K +L E+ E+ +L
Sbjct: 722 DREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKL 781
Query: 580 KEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENF 639
KE+ L + E+V++ N+E S + Q ++ Q EEN
Sbjct: 782 KEQY------DAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQ---EEN- 831
Query: 640 LQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSI 699
E +SE E+ + L + + + K D KE LKK+ E + E ++
Sbjct: 832 --EKLQGRSE---------ELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEAL 880
Query: 700 SRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKI 741
+++ + R++ENE + + + +E LS+K+
Sbjct: 881 VHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKL 922
Score = 75.5 bits (184), Expect = 2e-13
Identities = 134/762 (17%), Positives = 317/762 (41%), Gaps = 97/762 (12%)
Query: 51 QPQSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLS 110
QP KVL+ E Q + ++ ++ +EE + + ++ T S +
Sbjct: 463 QPNIDGKVLET--EGSQESTVIRAPSLGAQSKKEEEVKTATATLMLQNRATATSPDSGAK 520
Query: 111 GDSVNSLPQSVNV---PSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFL 167
SV + P + N P + + LT +T+ + + + E S
Sbjct: 521 KISVKTFPSASNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEGS------------- 567
Query: 168 PTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTN 227
T + + ++ +K + T+ G + + C+S ++K+ L++ + +
Sbjct: 568 -TDNDDATKRKVNLVFEKIQ-TLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAE 625
Query: 228 ELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLP 287
+ LQ + +N K + + + + N N ++ +R+ E E ++K L
Sbjct: 626 LQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQ-QRLEESEGELRKNLE 684
Query: 288 FRETVSKFHVHFCRKCKKLSK--SEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTL 345
V + + L SEMH + K +++ G I +L + + L
Sbjct: 685 ELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDRE-KGALIEELLQAKQDLQDLL 743
Query: 346 SFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQ-- 403
++ + ++ +ER+ +K + +++ + EQ A++Q L+ ++E+ +
Sbjct: 744 IAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNV 803
Query: 404 ----------------IQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLV 447
+ +V L+ EN L+ + + L L +++E +
Sbjct: 804 EVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAK 863
Query: 448 EEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEAL- 506
E + ++ + EE KE K+ +S L+ + + + Q + E++Q+ E L
Sbjct: 864 ETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLK 923
Query: 507 ------DQLKSKEHKTQSDMAIVNNENNRMSIEM----EAMKTNILLIQDEKEMLEKKTH 556
+QL+ +++ +++ + ++ EM EA +T+ L +Q++ + ++K
Sbjct: 924 EESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNR 983
Query: 557 QLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTA 616
+ L E + +LKE LE EK RL + + ++++E +E + + E+
Sbjct: 984 RELAE---MQRQLKEKTLEA----EKSRLTAMKMQDEMRLME---EELRDYQRAQDEALT 1033
Query: 617 ARQIMEREIENIQTYQSTAEENFLQE----IKNAKSEASIYKNSLSEIGKECEMLSKMVM 672
RQ++E+ +++++ Y+ A+ + + +K + + S + L E ++LS+ +
Sbjct: 1034 KRQLLEQTLKDLE-YELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERIS 1092
Query: 673 ETKTDNQILKEEL--KKHSQENIKFEN-SISRLTED---KIL------------------ 708
++ + L+ EL ++ ++++++ + S+ R +D +I+
Sbjct: 1093 RSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQME 1152
Query: 709 -----LENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQH 745
LE+ + S E +R L+ R L+R+ L ++ ++H
Sbjct: 1153 ARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEH 1194
Score = 68.6 bits (166), Expect = 2e-11
Identities = 152/793 (19%), Positives = 317/793 (39%), Gaps = 104/793 (13%)
Query: 21 SKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMP 80
S+ S++G ++ S +E + E ++++ + A LQ+QL+ L ++ QN+
Sbjct: 590 SRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVA--ELQRQLQ----LEVKNQQNIKEE 643
Query: 81 TENQEENLSMEKSHH---FEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRT 137
E NL +S H E++ TL E+ G+ +L + V +
Sbjct: 644 RERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQ-------- 695
Query: 138 STDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGF 197
H +E D+ + + L +A + + +I + +
Sbjct: 696 -----------HQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAK-------- 736
Query: 198 CENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFI 257
++L D+ + ++ ++ L+K AL L K ++S H +M+ +
Sbjct: 737 -QDLQDLLIAKEEQEDLLRKRERELTALKGAL-------------KEEVSS-HDQEMDKL 781
Query: 258 KEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKN 317
KE+ D L +S + E V+ L T + + K L + ++
Sbjct: 782 KEQ-YDAELQALRES--VEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRS 838
Query: 318 EKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKT 377
E+ + + + I DLK + TL K+E + ++ + LV E E
Sbjct: 839 EELERRVAQLQRQIEDLKGDEAKAKETLK-----KYEGEIRQLEEALVHARK--EEKEAV 891
Query: 378 SKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVE 437
S ++ + A L +E Q+ +K+ E + L+ + L + +E
Sbjct: 892 SARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIE 951
Query: 438 TYEKQLKNLVEEKST----IQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNI 493
+K++ ++VE T +Q++L + +E ++ L E ++ Q + KTLE +
Sbjct: 952 KLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQR--------QLKEKTLEAEKS 1003
Query: 494 QLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEK 553
+L+ K Q L + + ++++ D A+ R +E ++D + LE
Sbjct: 1004 RLTAMKMQDEMRLMEEELRDYQRAQDEAL----TKRQLLEQ--------TLKDLEYELEA 1051
Query: 554 KTHQLLKEKSSLGNEL--KESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTL 611
K+H L ++S L ++ K SQLE ++L+E+ + + L + I +++ L L
Sbjct: 1052 KSH-LKDDRSRLVKQMEDKVSQLE-MELEEE----RNNSDLLSERISRSREQMEQLRNEL 1105
Query: 612 QESTAARQIMEREIENIQTYQSTAEENFLQ---EIKNAKSEASIYKNS-LSEIGKECEML 667
+ AARQ +E + +++ + + +++K + + ++E+ E
Sbjct: 1106 LQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESE 1165
Query: 668 SKMVMETKTDNQILKEELK----KHSQENIKFENSISRLTEDKILLENYVRSIENERDTL 723
+ + N+ L+ ++K + E++ + +L+ ++ V E E D L
Sbjct: 1166 ERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRL 1225
Query: 724 EFEMRHLQR---EYLSLSDKICNQHNDPSKTTYISRREKFHFDNYTHEDTSSPQSRPLAS 780
E + LQR E + +++ + Q N K + + D+ +D S L
Sbjct: 1226 ESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLPSKVLDDMDDDDDLSTDGGSLYE 1285
Query: 781 DLKGYFKVKDRTL 793
Y KD T+
Sbjct: 1286 APVSYTFSKDSTV 1298
Score = 37.0 bits (84), Expect = 0.072
Identities = 38/191 (19%), Positives = 77/191 (40%), Gaps = 20/191 (10%)
Query: 581 EKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEE--- 637
++E +T +ET QI+ E + A ++ + E IQT +S A
Sbjct: 543 QQELTQQTNEETAKQILYNYLKEG-----STDNDDATKRKVNLVFEKIQTLKSRAAGSAQ 597
Query: 638 ------NFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILK---EELKKH 688
N E+K+ + S ++E+ ++ ++ K K + + ++ EEL+
Sbjct: 598 GNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQ 657
Query: 689 SQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDP 748
E ++ +++ + E+ E +R E ++ E Q E L D++ H++
Sbjct: 658 HNEKVEENSTLQQRLEES---EGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDEL 714
Query: 749 SKTTYISRREK 759
REK
Sbjct: 715 DSAKRSEDREK 725
Score = 32.7 bits (73), Expect = 1.4
Identities = 69/352 (19%), Positives = 144/352 (40%), Gaps = 40/352 (11%)
Query: 404 IQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEY 463
I KV+E E + + P + ++V+T L +++ ++T S S ++
Sbjct: 466 IDGKVLETEGSQESTVIRA-PSLGAQSKKEEEVKTATATL--MLQNRATATSPDSGAKKI 522
Query: 464 SKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIV 523
S + + ++L+GQ + ++ N + + KQ + L KE T +D A
Sbjct: 523 SVKTFPSASNTQATPDLLKGQQELTQQTNEETA--KQILYNYL-----KEGSTDNDDA-T 574
Query: 524 NNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQ---LLKEKSSLGNELKESQLEIIQLK 580
+ N + +++ +K+ T + LL++KS L E+ E Q ++ QL+
Sbjct: 575 KRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQL-QLE 633
Query: 581 EKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEEN-- 638
K + + +K+E+ + L+E R ++E T Q EE+
Sbjct: 634 VKNQ-------------QNIKEERERMRANLEE---LRSQHNEKVEENSTLQQRLEESEG 677
Query: 639 ----FLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIK 694
L+E+ K E ++ + ++ + LS+M E + + E +E ++
Sbjct: 678 ELRKNLEELFQVKMEREQHQTEIRDLQ---DQLSEMHDELDSAKRSEDREKGALIEELLQ 734
Query: 695 FENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHN 746
+ + L K E+ +R E E L+ ++ + DK+ Q++
Sbjct: 735 AKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYD 786
>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
Length = 1780
Score = 80.5 bits (197), Expect = 6e-15
Identities = 124/598 (20%), Positives = 248/598 (41%), Gaps = 85/598 (14%)
Query: 177 QADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQT----- 231
Q + + +K +T+ N D + K + Q+ + + L+NE++T
Sbjct: 876 QQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSI 935
Query: 232 ----------------LQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNL-----NEDI 270
L+T V + D+ + +D N +E+NL N+ +
Sbjct: 936 TNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNL-RDLSNGSEEDNLPNTQLDLLGNDYL 994
Query: 271 KSKRISELEALVKKLLPFRETVSKFHVHF------CRKCKKLSKSEMHRGKKNEKNNKEI 324
SK++ E P RE + FH C++ K S + H+ ++ E+ +++
Sbjct: 995 VSKQVKEYRIQE----PNRE--NSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKL 1048
Query: 325 PITGKNITDLKFHSRVPRYTLSFLDQTKHEMKD---KERQPFLVKQGSIISENEKTS--K 379
K D + L + +H+ +D KE++ + + + E T +
Sbjct: 1049 QAEVKGYKDEN----------NRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQ 1098
Query: 380 VNSVTEQCVAKIQYLQNYL--KESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVE 437
+ V E A + Q K ++ + ++E + + +K++ I +S+I K+E
Sbjct: 1099 IQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLE 1158
Query: 438 TYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSL 497
+NL E + +Q + T++ + + LK ++I N LQ L+ K +
Sbjct: 1159 ------RNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEET 1212
Query: 498 EKQQMMEALDQLKSKEHKTQS----------DMAIVNNENNRMSIEMEAMKTNILLIQDE 547
+Q+ + ++L + +TQ+ D A + + +++ ++ + +++DE
Sbjct: 1213 NRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDE 1272
Query: 548 KEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNL 607
++L K ++L K+K+ EL Q I QLKE+ K E E + Q KD LN+
Sbjct: 1273 DKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVE-EAIQQYERACKD--LNV 1329
Query: 608 ETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEML 667
+ + E R +E E E Q Q E L+E++ +E +K +++ +
Sbjct: 1330 KEKIIED--MRMTLE-EQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQR 1386
Query: 668 SKMVMETKTD----NQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERD 721
S E TD L++EL++ Q K+ + E+K++L + EN R+
Sbjct: 1387 SNKEHENNTDVLGKLTNLQDELQESEQ---KYNADRKKWLEEKMMLITQAKEAENIRN 1441
Score = 65.1 bits (157), Expect = 2e-10
Identities = 116/572 (20%), Positives = 236/572 (41%), Gaps = 48/572 (8%)
Query: 204 ICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLD 263
IC+ ++ ++ + E NE + Q +P + + S I +D+ K E +
Sbjct: 772 ICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQK---KSEEVR 828
Query: 264 GNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKE 323
N+ E I+ R+ L+ + L F T+ + + +L+K +H ++ + K+
Sbjct: 829 PNIAE-IEDIRV--LQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKK 885
Query: 324 IPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSV 383
K + ++ + Y ++ + + K++E++ ++K + I E S N+V
Sbjct: 886 NLTLSKEVQQIQSN-----YDIAIAELHVQKSKNQEQEEKIMKLSNEI-ETATRSITNNV 939
Query: 384 TEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQL 443
++ + + + +SV + L +L+ S+ L T L+ KQ+
Sbjct: 940 SQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQV 999
Query: 444 KNL-VEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQM 502
K ++E + S S E +EC K+I+ + Q + LE++ +L E +
Sbjct: 1000 KEYRIQEPNRENSFHSSIEAIWEEC----KEIVKASSKKSHQIEELEQQIEKLQAEVKGY 1055
Query: 503 MEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEK 562
+ ++LK KEHK Q D+ +K LIQ KE L++K L +
Sbjct: 1056 KDENNRLKEKEHKNQDDL----------------LKEKETLIQQLKEELQEKNVTLDVQI 1099
Query: 563 SSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIME 622
+ E K + E+ Q + E ET+L+ + LE + E + +E
Sbjct: 1100 QHVV-EGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLE 1158
Query: 623 REIENIQTYQSTAEENF----LQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDN 678
R ++ Q + + +N ++E+K K E + N+L ++ ++ + + +
Sbjct: 1159 RNLKEFQEHLQDSVKNTKDLNVKELK-LKEEITQLTNNLQDMKHLLQLKEEEEETNRQET 1217
Query: 679 QILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLS 738
+ LKEEL S + + R ED L+ + + + ++ E+ ++ E L
Sbjct: 1218 EKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLR 1277
Query: 739 DKI---------CNQHNDPSKTTYISRREKFH 761
KI C+Q D + T +E+ +
Sbjct: 1278 IKINELEKKKNQCSQELDMKQRTIQQLKEQLN 1309
Score = 58.5 bits (140), Expect = 2e-08
Identities = 136/683 (19%), Positives = 275/683 (40%), Gaps = 81/683 (11%)
Query: 101 TLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNY 160
TL+S +EKL G +S Q V++ S +S+ L ++ +T + N + E+ D+++
Sbjct: 484 TLNSSQEKLFGPVKSS--QDVSLDSNSNSK-ILNVKRATISWE-NSLEDLMEDEDLVEEL 539
Query: 161 NNFYRFLPTAPPNVMSQADTVILDKS-KITVPFLKHGFCENLDDICHSIKQ-MKEELQKS 218
N NV ++ LDK+ + F+ H L D+ +K+ + E ++
Sbjct: 540 EN-----AEETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLKKKLINEKKEK 594
Query: 219 HDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLN----------- 267
E + E+ T R + + + + + I EEN + L
Sbjct: 595 LTLEFKIREEVTQEFTQYWAQREADFKETLLQERE---ILEENAERRLAIFKDLVGKCDT 651
Query: 268 -----EDIKSKRISELEALVKKLLPFRET---VSKFHVHFCRKCKKLSKSEMHRG---KK 316
+DI + ++ EA L F + ++K + ++L K E ++
Sbjct: 652 REEAAKDICATKVETEEATACLELKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQE 711
Query: 317 NEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMK------DKERQPFLVKQGSI 370
E +NK+I + I +L T++ K M+ DK L+ +
Sbjct: 712 LETSNKKIITQNQRIKELINIIDQKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKL 771
Query: 371 ISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQ 430
I +S ++ C + + +N L++ KK S + K +
Sbjct: 772 ICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNI 831
Query: 431 SLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEE 490
+ I+ + ++ + L TI+++L +E E K+ Q + E+
Sbjct: 832 AEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVH-------FQQELSLSEK 884
Query: 491 KNIQLSLEKQQMME----ALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQD 546
KN+ LS E QQ+ A+ +L ++ K Q + +N + ++ N+ I
Sbjct: 885 KNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQI-- 942
Query: 547 EKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLK------EKERLAKTEQETL---LQII 597
K H + E +L + + S ++++ L+ E++ L T+ + L +
Sbjct: 943 ------KLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVS 996
Query: 598 ETVKDEKL---NLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYK 654
+ VK+ ++ N E + S A +EI + +S E Q+I+ ++E YK
Sbjct: 997 KQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYK 1056
Query: 655 NSLSEI-GKECEMLSKMVMETKTDNQILKEELKKHS-------QENIKFENSISRLTEDK 706
+ + + KE + ++ E +T Q LKEEL++ + Q ++ + ++S LT+
Sbjct: 1057 DENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGV 1116
Query: 707 ILLENYVRSIENERDTLEFEMRH 729
+ ++ +E +T + E H
Sbjct: 1117 TCYKAKIKELETILETQKVECSH 1139
Score = 48.1 bits (113), Expect = 3e-05
Identities = 85/410 (20%), Positives = 179/410 (43%), Gaps = 59/410 (14%)
Query: 380 VNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETY 439
+NS E+ ++ Q+ +S K++ ++ ++ ++ ++ L+ + L++++E
Sbjct: 485 LNSSQEKLFGPVKSSQDVSLDS-NSNSKILNVKRATISWENSLEDLM-EDEDLVEELENA 542
Query: 440 EKQLKNLVEEKSTIQSKLSKTEEYSKECL--KEFKKIISKYNVLQGQNKTLEEKNIQLSL 497
E + +N+ E + L KT E +K + +E +K++ L+ K + EK +L+L
Sbjct: 543 E-ETQNV--ETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLK--KKLINEKKEKLTL 597
Query: 498 EKQQMMEALDQLKS---------KEHKTQSDMAIVNNENNRMSI------EMEAMKTNIL 542
E + E + KE Q + N R++I + + +
Sbjct: 598 EFKIREEVTQEFTQYWAQREADFKETLLQEREILEENAERRLAIFKDLVGKCDTREEAAK 657
Query: 543 LIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKD 602
I K E+ T L + + + EL +++ E+I+ KE+ + + E ++L+Q +ET
Sbjct: 658 DICATKVETEEATACLELKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNK 717
Query: 603 EKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYK----NSLS 658
+ + ++E E I Q +S E F K S I N
Sbjct: 718 KIITQNQRIKELINIIDQKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETV 777
Query: 659 EIGKECEMLSKMVMETK--TDNQILKEE-------------LKKHSQENIKFENSISRLT 703
E+ K+ + SK+ E K +N++ ++E + + +++ + +I+ +
Sbjct: 778 EVPKDSK--SKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIE 835
Query: 704 EDKILLEN------YVRSIEN-------ERDTLEFEMRHLQREYLSLSDK 740
+ ++L EN ++ +IEN E+ L ++ H Q+E LSLS+K
Sbjct: 836 DIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQE-LSLSEK 884
Score = 44.3 bits (103), Expect = 5e-04
Identities = 122/695 (17%), Positives = 273/695 (39%), Gaps = 125/695 (17%)
Query: 50 IQPQSALKVLQQQLESFQALRMQTLQN---VSMPTENQEENLSMEKSHHFEDSKTLHSV- 105
++ +S + L++ L+ FQ +++N +++ +E ++ + +++ +D K L +
Sbjct: 1148 LEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEIT-QLTNNLQDMKHLLQLK 1206
Query: 106 --EEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNF 163
EE+ + L + ++ S T NL +++ + +D+ + +
Sbjct: 1207 EEEEETNRQETEKLKEELSASS-----------ARTQNLKADLQRKEEDYADLKEKLTDA 1255
Query: 164 YRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFC-ENLDDICHSIKQMKEELQKSHDGE 222
+ + V D L + KI K C + LD +I+Q+KE+L E
Sbjct: 1256 KKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEE 1315
Query: 223 VALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALV 282
E + D++ K I +D ++E+ + + ++ E+E L
Sbjct: 1316 AIQQYE----RACKDLNVKEK-----IIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLA 1366
Query: 283 KKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPR 342
+L ++E KC L R K +NN ++ GK +T+L+
Sbjct: 1367 TELEKWKE-----------KCNDLETKNNQRSNKEHENNTDV--LGK-LTNLQDEL---- 1408
Query: 343 YTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESV 402
Q + + +R+ +L ++ +I++ ++ + + + ++ Y ++
Sbjct: 1409 -------QESEQKYNADRKKWLEEKMMLITQAKEAENIRN---------KEMKKYAEDRE 1452
Query: 403 QIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEE 462
+ K+ E+E L K L + Q V E QLK L I S + K E
Sbjct: 1453 RFFKQQNEMEILTAQLTEKDSDLQKWREERDQLVAALEIQLKAL------ISSNVQKDNE 1506
Query: 463 YSKECLKEFKKIISKYNVLQGQNKTLEEKNI------QLSLEKQQMMEALDQLKSKEHKT 516
+++ K+IIS+ + ++ Q ++ K I +L E + + K ++
Sbjct: 1507 -----IEQLKRIISETSKIETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKIEDGSV 1561
Query: 517 QSDMAIVNNENNR--------MSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNE 568
D V+ EN++ + I+ ++ N + ++ T ++ K + NE
Sbjct: 1562 VLDSCEVSTENDQSTRFPKPELEIQFTPLQPNKMAVK-HPGCTTPVTVKIPKARKRKSNE 1620
Query: 569 LKESQLEIIQLK--------------EKERLAKTEQETLLQ--------IIETVKDEKLN 606
++E ++ K ++ K EQ+ ++ + +N
Sbjct: 1621 MEEDLVKCENKKNATPRTNLKFPISDDRNSSVKKEQKVAIRPSSKKTYSLRSQASIIGVN 1680
Query: 607 LETTLQESTAAR---------QIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSL 657
L T +E T + I++ + + I S+++ + ++ K S+ K L
Sbjct: 1681 LATKKKEGTLQKFGDFLQHSPSILQSKAKKIIETMSSSKLSNVEASKENVSQPKRAKRKL 1740
Query: 658 --SEIGKECEMLSKMVM----ETKTDNQILKEELK 686
SEI ++ ++++ ++D+QI+K L+
Sbjct: 1741 YTSEISSPIDISGQVILMDQKMKESDHQIIKRRLR 1775
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 79.7 bits (195), Expect = 1e-14
Identities = 132/597 (22%), Positives = 256/597 (42%), Gaps = 104/597 (17%)
Query: 207 SIKQMKEELQKSHDGEVALTNELQTLQTD-PDVHRNGKYDMSPIHQDKMNFIKEENLDGN 265
S +Q ++E+++ H L E ++L+ + ++HR + Q + +FI + N++
Sbjct: 1348 SKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQK-----RQQQKDFI-DGNVESL 1401
Query: 266 LNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKL---SKSEMHRGKKNEKN-- 320
+ E K + E +V ++ +T+ K R+ +L ++SE+ K+ KN
Sbjct: 1402 MTELEIEKSLKHHEDIVDEIECIEKTLLKRRSEL-READRLLAEAESELSCTKEKTKNAV 1460
Query: 321 ------NKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKD--KERQPFLVKQGSIIS 372
+ + T + +L+ ++ L DQ ++ K+ + +KQ I+
Sbjct: 1461 EKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILK 1520
Query: 373 ENEKTSKVNSVTEQCVAK--------IQYLQN--------------YLKES-VQIQKKVM 409
E K QC++K +Q LQ LKES V +Q K
Sbjct: 1521 EINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRA 1580
Query: 410 ELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTE-EYSKEC- 467
ELE + S+ + + + L K E ++V+ K+ +Q L E E +++C
Sbjct: 1581 ELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCN 1640
Query: 468 -LKEFKKIISKYNVLQGQ-NKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNN 525
++E K ++ + + +G+ N + E+ QL+L KQ++ K + ++ +V
Sbjct: 1641 HIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEI-----------EKEEENLQVVLR 1689
Query: 526 ENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERL 585
+ ++ E++ NIL +ML+ + H+L K L ++ + S+LE Q+ E
Sbjct: 1690 QMSKHKTELK----NIL------DMLQLENHELQGLK--LQHDQRVSELEKTQVAVLEE- 1736
Query: 586 AKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKN 645
K E E L QI + K E +Q++ER+ I+ + TAE LQ
Sbjct: 1737 -KLELENLQQISQQQKGE----------IEWQKQLLERDKREIE--RMTAESRALQSCVE 1783
Query: 646 AKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQIL--KEELKKHSQENI--------KF 695
S+ ++ ++C++ K + +TK ++L EE K Q N+ K
Sbjct: 1784 CLSKEK------EDLQEKCDIWEKKLAQTK---RVLAAAEENSKMEQSNLEKLELNVRKL 1834
Query: 696 ENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTT 752
+ + +L DK+ L N + +++ + + LQ E ++ D + D TT
Sbjct: 1835 QQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTT 1891
Score = 75.1 bits (183), Expect = 2e-13
Identities = 94/498 (18%), Positives = 220/498 (44%), Gaps = 76/498 (15%)
Query: 271 KSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKN 330
K I E+++L+++L F++ + +V + +L+ + K+ E + K+
Sbjct: 1638 KCNHIREVKSLLEEL-SFQK--GELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKH 1694
Query: 331 ITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAK 390
T+LK + LD ++++ E Q ++ +SE EKT + +
Sbjct: 1695 KTELK----------NILDML--QLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELEN 1742
Query: 391 IQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEK 450
+Q + K ++ QK+++E + K +++ + +++L VE K+ ++L E+
Sbjct: 1743 LQQISQQQKGEIEWQKQLLERD------KREIERMTAESRALQSCVECLSKEKEDLQEKC 1796
Query: 451 STIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQ-LSLEKQQMMEALDQL 509
+ KL++T K++++ +N +E+ N++ L L +++ + LDQL
Sbjct: 1797 DIWEKKLAQT-----------KRVLAAAE----ENSKMEQSNLEKLELNVRKLQQELDQL 1841
Query: 510 KSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQD-----EKEMLEKKTHQ--LLKEK 562
+ +D++ + + + +++ + +QD ++++L HQ LL E+
Sbjct: 1842 NRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQ 1901
Query: 563 SSL----------------GNELKESQLEIIQLK-EKERLAKTEQETLLQIIETVKDEKL 605
+ L E K+ QL+++Q + E+ +L +QE + Q ++ ++ +
Sbjct: 1902 TRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESE- 1960
Query: 606 NLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECE 665
E+ L+ S + + ++E T Q + + L ++ A+ +L E + CE
Sbjct: 1961 --ESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERV----RTLQEEERWCE 2014
Query: 666 MLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYV--------RSIE 717
L K + +TK +++L + S E + + + D LL N + +
Sbjct: 2015 SLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVA 2074
Query: 718 NERDTLEFEMRHLQREYL 735
+ ++ L+ + L++ L
Sbjct: 2075 SLKEALKIQRSQLEKNLL 2092
Score = 54.3 bits (129), Expect = 4e-07
Identities = 96/471 (20%), Positives = 186/471 (39%), Gaps = 83/471 (17%)
Query: 326 ITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDK--ERQPFLVKQGSIISENEKTSKVNSV 383
+ G+ +T R++L +++ + +++ K E + KQ + E + K+N
Sbjct: 250 LEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKS 309
Query: 384 TEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQL 443
LKE +QK+ E +LN K+++ Q I+ +KQ
Sbjct: 310 --------------LKEEAMLQKQSCEELKSDLNTKNEL-----LKQKTIELTRACQKQY 350
Query: 444 KNLVEEKS--TIQSKLSKTEEYSKECLKEFK---------KIISKYNVLQGQNKTLEEKN 492
+ L +E + I +K Y E + K K K N+ ++ ++
Sbjct: 351 E-LEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQ 409
Query: 493 IQLSLEKQQMMEAL--DQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEM 550
+ ++K + E L D + + H T D + + E ++ A +T + + DE
Sbjct: 410 A-VQIKKMEPDEQLRNDHMNLRGH-TPLDTQLEDKEK-----KISAAQTRLSELHDE--- 459
Query: 551 LEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETT 610
+EK Q+L+ + QL+ I K+ L K + LQ++ ++ E L+LE
Sbjct: 460 IEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYK-QLSGRLQLVNKLRQEALDLELQ 518
Query: 611 LQESTAARQIMEREIENIQTY-----QSTAEENFLQEIKNAKSEASIYKNS--------- 656
+++ ++EI+++Q + + ++ K+ K + N
Sbjct: 519 MEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRL 578
Query: 657 ---LSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENI----------------KFEN 697
LS I KE E + K + E T+ QI E K E + + +N
Sbjct: 579 DEILSRIAKETEEI-KDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQN 637
Query: 698 SISRLTEDKILLENYVRSIENERDTLE---FEMRHLQREYLSLSDKICNQH 745
+L ++K L + +E ERD LE + ++++E L + QH
Sbjct: 638 ECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQH 688
Score = 53.5 bits (127), Expect = 7e-07
Identities = 142/739 (19%), Positives = 295/739 (39%), Gaps = 151/739 (20%)
Query: 46 SENQIQPQSALKVLQQQLESFQALRMQTLQNVSMPTENQ----EENLSMEKSHHFEDSKT 101
S+++ + ++ L +LQ + Q L++Q Q VS + Q EE L +E
Sbjct: 1692 SKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELEN--------- 1742
Query: 102 LHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDN---LSSNIIIHPSENSDILK 158
L + ++ G+ + Q+ D + T L S + E D+ +
Sbjct: 1743 LQQISQQQKGE--------IEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQE 1794
Query: 159 NYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKS 218
+ + + L + + + +++S NL+ + +++++++EL +
Sbjct: 1795 KCDIWEKKLAQTKRVLAAAEENSKMEQS-------------NLEKLELNVRKLQQELDQL 1841
Query: 219 HDGEVALTNELQTLQTDPDVHR---NGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRI 275
+ +++L N++ +Q R N + QD +N K++ L ++D+ +
Sbjct: 1842 NRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDV---LL 1898
Query: 276 SELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLK 335
SE L K + E ++F C+ K+ E +++ + I + K
Sbjct: 1899 SEQTRLQKDI---SEWANRF-----EDCQ----------KEEETKQQQLQVLQNEIEENK 1940
Query: 336 FHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEK--TSKVNSVTEQCVAKIQY 393
++ + + F + KER+ SE K TSKV
Sbjct: 1941 L--KLVQQEMMF------QRLQKERE----------SEESKLETSKVT------------ 1970
Query: 394 LQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTI 453
++++ +LE E + KSK+ ++ KV E++++ L EE+
Sbjct: 1971 ----------LKEQQHQLEKELTDQKSKL-------DQVLSKVLAAEERVRTLQEEERWC 2013
Query: 454 QSKLSKTEEYSKECLKE-FKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMM----EALDQ 508
+S L KT +K L E ++++ K L K + SL + Q + +A Q
Sbjct: 2014 ES-LEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQ 2072
Query: 509 LKS-----KEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKS 563
+ S K ++Q + ++ + I+ E M T L+ QD E + +L+KE +
Sbjct: 2073 VASLKEALKIQRSQLEKNLLEQKQENSCIQKE-MATIELVAQDNHE----RARRLMKELN 2127
Query: 564 SLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDE----KLNLETTLQESTAARQ 619
+ E E + ++ K+ ER + + + VKDE NL L E A +
Sbjct: 2128 QMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLE 2187
Query: 620 IMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQ 679
+ EN++ + +EN + E K + S++ +M+ +
Sbjct: 2188 AILERNENLEGELESLKENLPFTMNEGPFEE---KLNFSQV---------HIMDEHWRGE 2235
Query: 680 ILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSD 739
L+E+L +H ++ +K + + ++L I+ +R T E + L+R+ +L +
Sbjct: 2236 ALREKL-RHREDRLKAQLRHCMSKQAEVL-------IKGKRQT-EGTLHSLRRQVDALGE 2286
Query: 740 KICNQHNDPSKTTYISRRE 758
+ + D + + +S+ E
Sbjct: 2287 LVTSTSADSASSPSLSQLE 2305
Score = 52.8 bits (125), Expect = 1e-06
Identities = 128/724 (17%), Positives = 284/724 (39%), Gaps = 90/724 (12%)
Query: 60 QQQLESFQALRMQTLQNVSMPTEN---QEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNS 116
Q + E+F+ ++ ++ + E + E L +++ E+ K + + L +++
Sbjct: 258 QDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQ 317
Query: 117 LPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMS 176
+ S +++++ L L+ T L+ + L+ FY+ P
Sbjct: 318 KQSCEELKSDLNTKNEL-LKQKTIELT-----RACQKQYELEQELAFYKIDAKFEPLNYY 371
Query: 177 QADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDP 236
++ +DK+ P++ + K + + + +Q + +P
Sbjct: 372 PSEYAEIDKAPDESPYIGKS-------------RYKRNMFATESYIIDSAQAVQIKKMEP 418
Query: 237 DVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFH 296
D + D MN LD L + K K+IS + + +L + + K
Sbjct: 419 D---------EQLRNDHMNLRGHTPLDTQLED--KEKKISAAQTRLSEL---HDEIEKAE 464
Query: 297 VHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMK 356
R ++ + E K+I GK++ + R L +++ + E
Sbjct: 465 QQILRATEEFKQLE------EAIQLKKISEAGKDLLYKQLSGR-----LQLVNKLRQEAL 513
Query: 357 DKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENL 416
D E Q + KQ I+ +K K + + +++K QK E + + +
Sbjct: 514 DLELQ--MEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKA----QKSGKEQQLDIM 567
Query: 417 NLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIIS 476
N + + L ++ ++ +++K+L E+ + + +++ E K+ +
Sbjct: 568 N--KQYQQLESRLDEILSRIAKETEEIKDLEEQLT--EGQIAANEALKKDLEGVISGLQE 623
Query: 477 KYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSI---- 532
++GQ + + +L EK+ +++ L +++ + + Q ++ ++ EN R +
Sbjct: 624 YLGTIKGQATQAQNECRKLRDEKETLLQRLTEVE--QERDQLEIVAMDAENMRKELAELE 681
Query: 533 ----EMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKT 588
E + ++ Q + E + L + + N+LKE +L++ RL +
Sbjct: 682 SALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKE------ELEKVTRLTQL 735
Query: 589 EQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNA-K 647
EQ L +E E+ L+ L ++ + E+E EN + + A+ LQ+ N K
Sbjct: 736 EQSALQAELEK---ERQALKNALGKAQFSE---EKEQENSELH---AKLKHLQDDNNLLK 786
Query: 648 SEASIYKNSLSEIGKEC---EMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTE 704
+ ++N L+ + E ++ V E + ++ E+ HS ++ S++ L
Sbjct: 787 QQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDV-LGKSLADL-- 843
Query: 705 DKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRREKFHFDN 764
K E RS + ERD + R LQ E +K+ + + + + +FD
Sbjct: 844 QKQFSEILARS-KWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDK 902
Query: 765 YTHE 768
HE
Sbjct: 903 RQHE 906
Score = 52.0 bits (123), Expect = 2e-06
Identities = 101/554 (18%), Positives = 236/554 (42%), Gaps = 81/554 (14%)
Query: 252 DKMNFIKEENLDGNL--NEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKS 309
+++ ++E+ +G + NE +K +LE ++ L + T+ +C+KL
Sbjct: 590 EEIKDLEEQLTEGQIAANEALKK----DLEGVISGLQEYLGTIKGQATQAQNECRKLRDE 645
Query: 310 E---MHRGKKNEKNNKEIPITG-------KNITDLKFHSRVPRYTLSFLDQTKHEMKDKE 359
+ + R + E+ ++ I K + +L+ + + L QT+ ++ E
Sbjct: 646 KETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYE 705
Query: 360 RQPFL------VKQGSIISENEKTSKVNSVTEQCV-AKIQYLQNYLKESVQIQKKVMELE 412
+ + + E EK +++ + + + A+++ + LK ++ + E E
Sbjct: 706 AELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKE 765
Query: 413 SENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFK 472
EN L +K+K L L Q+++ ++ L ++V+ + ++ +E ++ LK
Sbjct: 766 QENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRK-LKLGT 824
Query: 473 KIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNE------ 526
++ ++ K+L + Q S + D+ + +E K Q +MA+ +
Sbjct: 825 GEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQE 884
Query: 527 ----------NNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLE- 575
RM+ + + I +++E L++ + + + +L+E+ E
Sbjct: 885 EFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEK 944
Query: 576 ---IIQLKEKERLAKTE----QETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENI 628
+ QL+E E+ K E QE + + + +K K + T+ + +TA I + +++++
Sbjct: 945 ERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSL 1004
Query: 629 -----QTYQSTAEE------------NFLQEIKNAKSEASIYKNSLSEIGKECEM-LSKM 670
+ Q AEE +++ A++E + +N L + G++ + + K
Sbjct: 1005 HGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKT 1064
Query: 671 VMETKTDNQILKEELKKHSQENIKFENSISRL--------TEDKILLENYVRSIENERDT 722
+ T ++Q+L+ E + E + E I+RL +++K EN + I R
Sbjct: 1065 GVGTGANSQVLEIEKLNETMERQRTE--IARLQNVLDLTGSDNKGGFENVLEEIAELRRE 1122
Query: 723 LEFEMRHLQREYLS 736
+ + Q +Y+S
Sbjct: 1123 VSY-----QNDYIS 1131
Score = 42.0 bits (97), Expect = 0.002
Identities = 65/334 (19%), Positives = 141/334 (42%), Gaps = 16/334 (4%)
Query: 447 VEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQN-KTLEE--KNIQLSLEKQQMM 503
V E +++++S+ E+ + LK K+ + Q+ K +EE NI L++++ +
Sbjct: 1315 VPEHHNLENEVSRLEDIMQH-LKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSL 1373
Query: 504 EA-LDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKT--NILLIQDEKEMLEKKTHQLLK 560
E +++L K Q ++ + E+E K+ + I DE E +EK LLK
Sbjct: 1374 ECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEK---TLLK 1430
Query: 561 EKSSLGNE---LKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAA 617
+S L L E++ E+ KEK + A + + + + + LE QE+
Sbjct: 1431 RRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVN 1490
Query: 618 RQIMEREIENIQTYQSTAEENFLQE---IKNAKSEASIYKNSLSEIGKECEMLSKMVMET 674
++++ ++Q E++ +++ +K + + + K+ E L++ + +
Sbjct: 1491 LVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKL 1550
Query: 675 KTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREY 734
+ D ++ + H Q + E + + L++ V S + E L+ ++ H + E
Sbjct: 1551 QKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEEL 1610
Query: 735 LSLSDKICNQHNDPSKTTYISRREKFHFDNYTHE 768
L + D + + E N+ E
Sbjct: 1611 HLLQGSMVQAKADLQEALRLGETEVTEKCNHIRE 1644
Score = 33.5 bits (75), Expect = 0.80
Identities = 38/180 (21%), Positives = 84/180 (46%), Gaps = 15/180 (8%)
Query: 556 HQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQEST 615
H + E +L NE+ + + LK K+R + + + Q + +++ N++ LQE
Sbjct: 1312 HCNVPEHHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKK 1371
Query: 616 AARQIMEREIENIQTYQSTAEENFLQ-EIKNAKSEASIYKN--SLSEIGKECEMLSKMVM 672
+ +E +Q Q +++F+ +++ +E I K+ +I E E + K ++
Sbjct: 1372 SLECEVEELHRTVQKRQQ--QKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLL 1429
Query: 673 ETKTD----NQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMR 728
+ +++ +++L E + S K +N++ + T+ K L ++ E D E E R
Sbjct: 1430 KRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSL------LQTESDAEELERR 1483
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 79.3 bits (194), Expect = 1e-14
Identities = 126/621 (20%), Positives = 272/621 (43%), Gaps = 73/621 (11%)
Query: 160 YNNFYRFLPTAPPN---VMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEEL- 215
Y + R+L +A PN S AD + + + T+ L++ H+ Q+K+E+
Sbjct: 399 YYSNRRYLSSANPNDNRTSSNADKSLQESLQKTI--------YKLEEQLHNEMQLKDEME 450
Query: 216 QKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRI 275
QK + L ++ L + + RN + +S I ++KM N E KR
Sbjct: 451 QKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKR- 509
Query: 276 SELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLK 335
+E V L E + K + +KLS+ + + N+ E + + K
Sbjct: 510 RNVENEVSTLKDQLEDLKKVSQNSQLANEKLSQLQKQLEEANDLLRTE---SDTAVRLRK 566
Query: 336 FHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQ-YL 394
H+ + + ++S L+ E++++ R I EN K S T++ ++Q L
Sbjct: 567 SHTEMSK-SISQLESLNRELQERNR----------ILENSK-----SQTDKDYYQLQAIL 610
Query: 395 QNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQ 454
+ ++ + + +L++ +L+ ++K L + ++KVE K+ ++++ +
Sbjct: 611 EAERRDRGHDSEMIGDLQARITSLQEEVKHL----KHNLEKVEGERKEAQDMLNHSEKEK 666
Query: 455 SKLSKTEEYSKECLKE-FKKIISKYNV----LQGQNKTLEEKNIQLSLEKQQMMEALDQL 509
+ L Y + L++ ++ ++++ V L +++++EE S+ +M + L +
Sbjct: 667 NNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAK---SVAMCEMEKKLKEE 723
Query: 510 KSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQL---LKEKSS-- 564
+ K ++ + + + + + ++++ + + + KE +E + L L+++S+
Sbjct: 724 REAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNKR 783
Query: 565 --LGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIME 622
L NELK E LK E+ K E TLL+ ++ E L + + + ++
Sbjct: 784 LLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQ 843
Query: 623 REIENIQTY---------------QSTAEENF--LQEIKNAKSEASIYKNSLSEIGKECE 665
++E Q + + EN +QE++N K E + L+E E E
Sbjct: 844 DQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEK-ETLATQLDLAETKAESE 902
Query: 666 MLSKMVMETK--TDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTL 723
L++ ++E + Q K+ ++ QE ++++SRL E +L + + E + L
Sbjct: 903 QLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENEEL 962
Query: 724 EFEMRHLQREY-LSLSDKICN 743
+M+ + EY L ++I N
Sbjct: 963 TEKMKKAEEEYKLEKEEEISN 983
Score = 43.1 bits (100), Expect = 0.001
Identities = 70/352 (19%), Positives = 143/352 (40%), Gaps = 50/352 (14%)
Query: 199 ENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIK 258
E ++D +K + +L++ + + L NEL+T + D + + M + ++N +
Sbjct: 763 ERMED---EVKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQM----KQEINTLL 815
Query: 259 EEN--LDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKK 316
E L+ L + K R +E + +++L E F + + K+L + + ++
Sbjct: 816 EAKRLLEFELAQLTKQYRGNEGQ--MRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRE 873
Query: 317 NEK------NNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSI 370
N K N KE T ++ + K S + L++ E+ + ++ + I
Sbjct: 874 NLKKIQELQNEKETLATQLDLAETKAESE--QLARGLLEEQYFELTQESKKAASRNRQEI 931
Query: 371 ISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKV-----MELESENLNLKSKMKPL 425
++ S++ I+ L+ +E + KK +E E E NLK+ +
Sbjct: 932 TDKDHTVSRLEEANSMLTKDIEILRRENEELTEKMKKAEEEYKLEKEEEISNLKAAFE-- 989
Query: 426 IFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQN 485
KN+ E++ ++K E K+FK K N +
Sbjct: 990 ------------------KNINTERTLKTQAVNKLAEIMNR--KDFKIDRKKANTQDLRK 1029
Query: 486 KTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDM--AIVNNENNRMSIEME 535
K E + +QL L +++ E +Q+ K K +DM +V +R ++M+
Sbjct: 1030 KEKENRKLQLELNQER--EKFNQMVVKHQKELNDMQAQLVEECAHRNELQMQ 1079
>gi|109134347 NY-REN-58 antigen [Homo sapiens]
Length = 701
Score = 77.4 bits (189), Expect = 5e-14
Identities = 119/570 (20%), Positives = 241/570 (42%), Gaps = 77/570 (13%)
Query: 198 CENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFI 257
CE+ ++K LQ H V L NEL+ L ++ Q+K+ +
Sbjct: 42 CEHHKANYQTLKAEHTRLQNEH---VKLQNELKHL-----------FNEKQTQQEKLQLL 87
Query: 258 KEENLDGNLNEDIKSKRISELEALVKKLL-------------PFRETVSKF--HVHFCRK 302
EE L G L E K +L+ L + L P RE V R
Sbjct: 88 LEE-LRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRA 146
Query: 303 CKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQP 362
+ E K ++ KE + +K+ S + R L++ K E++++
Sbjct: 147 VYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIAR-----LEEDKEELRNQLLNV 201
Query: 363 FLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKM 422
L K + +V + + V Q L+ E +++ + E++ N +
Sbjct: 202 DLTKD---------SKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQ 252
Query: 423 KPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQ 482
+ Q+ ++ +E EKQ NL E+ ++ +L + E + + + K + N L
Sbjct: 253 VRQLAEMQATVRSLEA-EKQSANLRAER--LEKELQSSSEQNTFLINKLHKAEREINTLS 309
Query: 483 GQNKTLEEKN-IQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNI 541
+ K L+ N ++++ K + A +L+ + +K QS++ + ++N + +E K +
Sbjct: 310 SKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHK--V 367
Query: 542 LLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVK 601
LL++ ++E++ K Q KE E +++ L+++ K E E L +E +K
Sbjct: 368 LLVEKDRELIRKV--QAAKE---------EGYQKLVVLQDE----KLELENRLADLEKMK 412
Query: 602 --------DEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIY 653
EK E L+ S A +I +E+++++ + + ++ + K+E S
Sbjct: 413 VEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRL-KLQQQIVTIENAEKEKNENSDL 471
Query: 654 KNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQE--NIKFENSISRLTEDKILLEN 711
K +S + + L++ + NQ+LKE +++ QE N + + ++L +K L E
Sbjct: 472 KQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEK 531
Query: 712 YVRSIENERDTLEFEMRHLQREYLSLSDKI 741
++ +E E+ L + + +Y +K+
Sbjct: 532 QIQWLE-EKHKLHERITDREEKYNQAKEKL 560
Score = 64.3 bits (155), Expect = 4e-10
Identities = 99/467 (21%), Positives = 192/467 (41%), Gaps = 59/467 (12%)
Query: 257 IKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKK 316
IK E+ L ED + R L + K E +++ V+ C+K K L K
Sbjct: 178 IKYESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAEL--K 235
Query: 317 NEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKH------EMKDKERQPFLVKQGSI 370
EK N E + ++ + + + T+ L+ K E +KE Q + +
Sbjct: 236 AEKENSEAQVENAQRIQVRQLAEM-QATVRSLEAEKQSANLRAERLEKELQSSSEQNTFL 294
Query: 371 ISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQ--KKVMELESENLNLKSKMKPLIFT 428
I++ K + + V ++++ ++++ + ELE E ++S++ L
Sbjct: 295 INKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSD 354
Query: 429 TQSLIQKVETYEKQLKNLVEEKSTIQSKL--SKTEEYSKECLKEFKKIISKYNVLQGQNK 486
+ L VE + K L LVE+ + K+ +K E Y K + + +K+ + N L K
Sbjct: 355 NEILKAAVE-HHKVL--LVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELE-NRLADLEK 410
Query: 487 TLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQD 546
E ++ EK Q E L + E T+ ++ S+ ++ + + +
Sbjct: 411 MKVEHDVWRQSEKDQYEEKLRASQMAEEITRKEL---------QSVRLKLQQQIVTIENA 461
Query: 547 EKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDE--- 603
EKE E S L ++ Q+++ L + E + L +++E +K E
Sbjct: 462 EKEK---------NENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRN 512
Query: 604 --------KLNLETTLQESTAA-----RQIMEREIENIQTYQSTAEENFLQEIKNAKSEA 650
+L E TL+E ++ ER + + Y A+E + K
Sbjct: 513 FRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQ-AKEKLQRAAIAQKKRK 571
Query: 651 SIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFEN 697
S+++N L + ++ E+L E +T+NQ+L +++N+ FE+
Sbjct: 572 SLHENKLKRLQEKVEVLEAKKEELETENQVL-------NRQNVPFED 611
Score = 46.2 bits (108), Expect = 1e-04
Identities = 50/198 (25%), Positives = 95/198 (47%), Gaps = 16/198 (8%)
Query: 543 LIQDEKEMLE--KKTHQLLK-EKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIET 599
++ DE+ E K +Q LK E + L NE + Q E+ L +++ T+QE L ++E
Sbjct: 34 MLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQ---TQQEKLQLLLEE 90
Query: 600 VKDEKLNLETTLQESTAARQIMEREIENIQTY-QSTAEENFLQEIKNAKSEASIYKNSLS 658
++ E + L+E + + +++E ++ Q E + +N E Y+ +
Sbjct: 91 LRGELVEKTKDLEEMKL-QILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYN 149
Query: 659 EIGKECEMLSKMVMETKTDNQILKEELKKHSQEN-IKFENSISRLTEDKILLENYVRSIE 717
++ E L K++ + KEE + E IK+E+ I+RL EDK L N + +++
Sbjct: 150 KLRYEHTFL-------KSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVD 202
Query: 718 NERDTLEFEMRHLQREYL 735
+D+ E ++ YL
Sbjct: 203 LTKDSKRVEQLAREKVYL 220
>gi|109134355 NY-REN-58 antigen [Homo sapiens]
Length = 701
Score = 77.4 bits (189), Expect = 5e-14
Identities = 119/570 (20%), Positives = 241/570 (42%), Gaps = 77/570 (13%)
Query: 198 CENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFI 257
CE+ ++K LQ H V L NEL+ L ++ Q+K+ +
Sbjct: 42 CEHHKANYQTLKAEHTRLQNEH---VKLQNELKHL-----------FNEKQTQQEKLQLL 87
Query: 258 KEENLDGNLNEDIKSKRISELEALVKKLL-------------PFRETVSKF--HVHFCRK 302
EE L G L E K +L+ L + L P RE V R
Sbjct: 88 LEE-LRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRA 146
Query: 303 CKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQP 362
+ E K ++ KE + +K+ S + R L++ K E++++
Sbjct: 147 VYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIAR-----LEEDKEELRNQLLNV 201
Query: 363 FLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKM 422
L K + +V + + V Q L+ E +++ + E++ N +
Sbjct: 202 DLTKD---------SKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQ 252
Query: 423 KPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQ 482
+ Q+ ++ +E EKQ NL E+ ++ +L + E + + + K + N L
Sbjct: 253 VRQLAEMQATVRSLEA-EKQSANLRAER--LEKELQSSSEQNTFLINKLHKAEREINTLS 309
Query: 483 GQNKTLEEKN-IQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNI 541
+ K L+ N ++++ K + A +L+ + +K QS++ + ++N + +E K +
Sbjct: 310 SKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHK--V 367
Query: 542 LLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVK 601
LL++ ++E++ K Q KE E +++ L+++ K E E L +E +K
Sbjct: 368 LLVEKDRELIRKV--QAAKE---------EGYQKLVVLQDE----KLELENRLADLEKMK 412
Query: 602 --------DEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIY 653
EK E L+ S A +I +E+++++ + + ++ + K+E S
Sbjct: 413 VEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRL-KLQQQIVTIENAEKEKNENSDL 471
Query: 654 KNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQE--NIKFENSISRLTEDKILLEN 711
K +S + + L++ + NQ+LKE +++ QE N + + ++L +K L E
Sbjct: 472 KQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEK 531
Query: 712 YVRSIENERDTLEFEMRHLQREYLSLSDKI 741
++ +E E+ L + + +Y +K+
Sbjct: 532 QIQWLE-EKHKLHERITDREEKYNQAKEKL 560
Score = 64.3 bits (155), Expect = 4e-10
Identities = 99/467 (21%), Positives = 192/467 (41%), Gaps = 59/467 (12%)
Query: 257 IKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKK 316
IK E+ L ED + R L + K E +++ V+ C+K K L K
Sbjct: 178 IKYESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAEL--K 235
Query: 317 NEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKH------EMKDKERQPFLVKQGSI 370
EK N E + ++ + + + T+ L+ K E +KE Q + +
Sbjct: 236 AEKENSEAQVENAQRIQVRQLAEM-QATVRSLEAEKQSANLRAERLEKELQSSSEQNTFL 294
Query: 371 ISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQ--KKVMELESENLNLKSKMKPLIFT 428
I++ K + + V ++++ ++++ + ELE E ++S++ L
Sbjct: 295 INKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSD 354
Query: 429 TQSLIQKVETYEKQLKNLVEEKSTIQSKL--SKTEEYSKECLKEFKKIISKYNVLQGQNK 486
+ L VE + K L LVE+ + K+ +K E Y K + + +K+ + N L K
Sbjct: 355 NEILKAAVE-HHKVL--LVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELE-NRLADLEK 410
Query: 487 TLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQD 546
E ++ EK Q E L + E T+ ++ S+ ++ + + +
Sbjct: 411 MKVEHDVWRQSEKDQYEEKLRASQMAEEITRKEL---------QSVRLKLQQQIVTIENA 461
Query: 547 EKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDE--- 603
EKE E S L ++ Q+++ L + E + L +++E +K E
Sbjct: 462 EKEK---------NENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRN 512
Query: 604 --------KLNLETTLQESTAA-----RQIMEREIENIQTYQSTAEENFLQEIKNAKSEA 650
+L E TL+E ++ ER + + Y A+E + K
Sbjct: 513 FRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQ-AKEKLQRAAIAQKKRK 571
Query: 651 SIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFEN 697
S+++N L + ++ E+L E +T+NQ+L +++N+ FE+
Sbjct: 572 SLHENKLKRLQEKVEVLEAKKEELETENQVL-------NRQNVPFED 611
Score = 46.2 bits (108), Expect = 1e-04
Identities = 50/198 (25%), Positives = 95/198 (47%), Gaps = 16/198 (8%)
Query: 543 LIQDEKEMLE--KKTHQLLK-EKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIET 599
++ DE+ E K +Q LK E + L NE + Q E+ L +++ T+QE L ++E
Sbjct: 34 MLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQ---TQQEKLQLLLEE 90
Query: 600 VKDEKLNLETTLQESTAARQIMEREIENIQTY-QSTAEENFLQEIKNAKSEASIYKNSLS 658
++ E + L+E + + +++E ++ Q E + +N E Y+ +
Sbjct: 91 LRGELVEKTKDLEEMKL-QILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYN 149
Query: 659 EIGKECEMLSKMVMETKTDNQILKEELKKHSQEN-IKFENSISRLTEDKILLENYVRSIE 717
++ E L K++ + KEE + E IK+E+ I+RL EDK L N + +++
Sbjct: 150 KLRYEHTFL-------KSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVD 202
Query: 718 NERDTLEFEMRHLQREYL 735
+D+ E ++ YL
Sbjct: 203 LTKDSKRVEQLAREKVYL 220
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 77.0 bits (188), Expect = 6e-14
Identities = 116/557 (20%), Positives = 238/557 (42%), Gaps = 73/557 (13%)
Query: 202 DDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEEN 261
DD+ +K ++ ++++ + L E T D R + + F+ E+
Sbjct: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDL---RQQNQALEKQLEKMRKFLDEQA 2073
Query: 262 LDGNLNEDIKSKRISELEALVKKLLPFR----------ETVSKFHVHFCRKCKKLSKSEM 311
+D D+ + I +LE +K + F+ E ++ KC +L S+
Sbjct: 2074 IDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKE 2133
Query: 312 HRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSII 371
+ ++ N+EI + +L+ V T ++ KH E +P L + +
Sbjct: 2134 QLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKH-FGAVEAKPELSLEVQLQ 2192
Query: 372 SENE----KTSKVNSVTEQCVAKIQYLQNYLKE------SVQIQKK-----VMELESENL 416
+E + K ++ ++ EQ + L+N +E ++IQKK + ELE EN
Sbjct: 2193 AERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENK 2252
Query: 417 NLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEK--STIQSKLSKTEEYSKEC--LKEFK 472
K M+ L I++ + Q ++++ K IQ K + ++ +++ L++
Sbjct: 2253 LFKDDMEKLGLA----IKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQL 2308
Query: 473 KIISKYNVLQGQNKTLEEKNIQLSL-------EKQQMMEALDQLKSKEHKTQSDMAIVNN 525
KI + V++ +N+ + + Q+ K+ E ++QL K Q ++A +
Sbjct: 2309 KITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQ 2368
Query: 526 ENNR----MSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKE 581
+ + +S E +++K + ++ EK LE++ +E + + N LKE+ ++ QL +
Sbjct: 2369 KTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQ 2428
Query: 582 KERLAKTEQETLLQI-----------IETVKDEKLNLETTLQESTAARQIMEREIENIQT 630
+ K E+E++ +I I+ + +K LE L E + +EN QT
Sbjct: 2429 ELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDAL------KSLEN-QT 2481
Query: 631 YQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQ 690
Y + EEN I N ++ ++++S E K + + + Q E L+K
Sbjct: 2482 YFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQK--- 2538
Query: 691 ENIKFENSISRLTEDKI 707
K N + ++ E+K+
Sbjct: 2539 ---KIVN-LQKIVEEKV 2551
Score = 76.3 bits (186), Expect = 1e-13
Identities = 157/773 (20%), Positives = 317/773 (41%), Gaps = 108/773 (13%)
Query: 19 SASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQQLESFQALRMQTLQNVS 78
S K SSE +K+ + E ++Q + ++ Q+ + LR + +
Sbjct: 383 SKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYG 442
Query: 79 MPTENQEENLSMEKSHHFEDSKTLHSVEEK----------LSGDSVNSLPQSVNVPSQIH 128
++ L + E+ KT H E + ++ D + + ++N I
Sbjct: 443 QQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAIN-ELNIK 501
Query: 129 SEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKI 188
+DT + + L + + E + + + L + + T+ +SK+
Sbjct: 502 LQDT---NSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKL 558
Query: 189 TVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTN---ELQTLQTDPDVHRNGKYD 245
E+L S + ++EL+ H+ EV TN +L+ L+ + + + +
Sbjct: 559 NEAHKSLSTVEDLKAEIVSASESRKELELKHEAEV--TNYKIKLEMLEKEKNAVLDRMAE 616
Query: 246 MSPIHQDKMN----FIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCR 301
+++ F EE L L ED++ + +E L L +H+ +
Sbjct: 617 SQEAELERLRTQLLFSHEEELS-KLKEDLEIEHRINIEKLKDNL----------GIHYKQ 665
Query: 302 KCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQ 361
+ L ++EM + + + K+ IT +N L+ S++ S ++ EM + +
Sbjct: 666 QIDGL-QNEMSQKIETMQFEKDNLITKQNQLILEI-SKLKDLQQSLVNSKSEEMTLQINE 723
Query: 362 PFLVKQGSIISENEKTS-KVNSVTEQCVAKIQYLQNYLKESVQ-IQKKVMELESENLNLK 419
L K+ I+ + EK + ++ K + L+ +KE +Q+K +LE+EN LK
Sbjct: 724 --LQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILK 781
Query: 420 SKMKPL-----IFTTQSLIQKV---ETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEF 471
+ K L I T S +++ ++ + + K+ V EK I+ + + E+ ++C++
Sbjct: 782 DEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKE-IEILIEENEDLKQQCIQLN 840
Query: 472 KKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQ----SDMAIVNNEN 527
++I + N K E +L E +++ D L+ ++K + S + +N E
Sbjct: 841 EEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL 900
Query: 528 NRMSIEMEAMKTNILLIQDEK----------EMLEKKTHQLL-------KEK-------S 563
+ I +K + ++K E++EK T +L+ +EK S
Sbjct: 901 HLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS 960
Query: 564 SLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMER 623
L +LK+ EI L E+ + K E+ E V LE + + A
Sbjct: 961 DLSEQLKQKHGEISFLNEEVKSLKQEK-------EQVSLRCRELEIIINHNRA------- 1006
Query: 624 EIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKT--DNQIL 681
EN+Q+ T + L + S + + S+S++ K SK+++E K +N +
Sbjct: 1007 --ENVQSC-DTQVSSLLDGVVTMTSRGA--EGSVSKVNKSFGEESKIMVEDKVSFENMTV 1061
Query: 682 KEELKKHSQENIKFENSISRLTEDKILLENYVRSIE-NERDTLEFEMRHLQRE 733
EE K QE + ++ S + E+ +R+ + +E D L+ E+ L+ E
Sbjct: 1062 GEESK---QEQLILDHLPS------VTKESSLRATQPSENDKLQKELNVLKSE 1105
Score = 65.9 bits (159), Expect = 1e-10
Identities = 149/833 (17%), Positives = 334/833 (40%), Gaps = 134/833 (16%)
Query: 12 EVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQQLESFQALRM 71
E +S L A K L++ E +K S +E + E +++ ++ + + +LE + +
Sbjct: 553 EQESKLNEAHKSLSTVEDLKAEIVSASE----SRKELELKHEAEVTNYKIKLEMLEKEKN 608
Query: 72 QTLQNVSMPTENQEENLSMEK--SHHFEDSKTLHSVE-------EKLSGDSVNSLPQSVN 122
L ++ E + E L + SH E SK +E EKL + Q ++
Sbjct: 609 AVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQID 668
Query: 123 VPSQIHSEDTLTLRTSTDNL---SSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQAD 179
S+ T++ DNL + +I+ S+ D+ ++ N T N + +
Sbjct: 669 GLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEI 728
Query: 180 TVILDKSK-------------ITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALT 226
++ + K + L+ E +D+ Q++ E L
Sbjct: 729 EILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAE-------NSILK 781
Query: 227 NELQTLQTDPDVHRNGKYDMSPIHQDK----MNFIKEENLDG----------NLNEDIKS 272
+E +TL+ +H +P+ Q++ ++ IK ++ D NED+K
Sbjct: 782 DEKKTLEDMLKIH-------TPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQ 834
Query: 273 KRISELEALVKKLLPFRETVSKFHVHFCRKCKKLS--------------KSEMHRGKKNE 318
+ I E + K+ F F V++ ++ + K E+ K +
Sbjct: 835 QCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLK 894
Query: 319 KNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEK-- 376
N+E+ + N T +K S V +F+ +T + E+ + + +++ EK
Sbjct: 895 ALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLE 954
Query: 377 -TSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQK 435
+ +++ ++EQ K + ++L E V K ++ E E ++L+ + +I + +
Sbjct: 955 LSQRLSDLSEQLKQKHGEI-SFLNEEV----KSLKQEKEQVSLRCRELEIIIN-HNRAEN 1008
Query: 436 VETYEKQLKNLVEEKSTIQSKLSK--TEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNI 493
V++ + Q+ +L++ T+ S+ ++ + +K +E K ++ + E K
Sbjct: 1009 VQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQE 1068
Query: 494 QLSLEKQQMMEALDQLK----SKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLI----- 544
QL L+ + L+ S+ K Q ++ ++ +E N + ++MEA + + L+
Sbjct: 1069 QLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHV 1128
Query: 545 ---------QDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKE------------ 583
+ +K + K + ++ + K QLE+ +K +E
Sbjct: 1129 DQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLI 1188
Query: 584 -RLAKTEQE-------TLLQIIETVKDEKLNLETTLQE-STAARQIMEREIENIQTYQST 634
+L K E TL ++ L E ++ + I E E +Q Y+
Sbjct: 1189 GKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYE 1248
Query: 635 AEE------NFLQEIKNAKSEASIYKNSLSEI------GKECEMLSKMVMETKTDNQILK 682
++ L ++ ++ + + LS+I G + E + + + +T+ +
Sbjct: 1249 VQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIH 1308
Query: 683 EELKKHSQENIKFENSISRLTE-DKILLENYVRSIENERDTLEFEMRHLQREY 734
++ ++ ++ +S L + +K LE V+ +E+ +L+ +++ ++ Y
Sbjct: 1309 SQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361
Score = 62.8 bits (151), Expect = 1e-09
Identities = 108/562 (19%), Positives = 240/562 (42%), Gaps = 98/562 (17%)
Query: 258 KEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKN 317
+++ ++ + E+I+ K + +E L K++ + + K L + + +KN
Sbjct: 312 QDKKVENSNKEEIQEKE-TIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKN 370
Query: 318 EK-NNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEK 376
++ N ++ +T + + + + + + K KD + + +V++ E E
Sbjct: 371 QEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQR----MEQET 426
Query: 377 TSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLN-LKSKMKPLIFTTQSLIQK 435
K+ EQ A++ + Y ++ VQ++++++ + +K++ K +
Sbjct: 427 QRKL----EQLRAELDEM--YGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSN 480
Query: 436 VETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQL 495
+ E Q+K + + + KL T ++ +E I+ + LQ Q + L E +L
Sbjct: 481 ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVE---EL 537
Query: 496 SLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKK- 554
S ++Q+ A + +E K NE ++ +E +K I+ + ++ LE K
Sbjct: 538 SFSREQIQRARQTIAEQESKL--------NEAHKSLSTVEDLKAEIVSASESRKELELKH 589
Query: 555 ----------THQLLKEKSSLGNELKESQ-LEIIQLK------EKERLAKTE-------- 589
L KEK+++ + + ESQ E+ +L+ +E L+K +
Sbjct: 590 EAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHR 649
Query: 590 ---------------------QETLLQIIETVKDEKLNLETTLQE---STAARQIMEREI 625
Q + Q IET++ EK NL T + + + +++ +
Sbjct: 650 INIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSL 709
Query: 626 ENIQTYQSTAEENFLQE----IKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTD---- 677
N ++ + T + N LQ+ ++ + E + + E+ + E+L K + E + D
Sbjct: 710 VNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEK 769
Query: 678 -------NQILKEELKKHSQENIKFENSISRLTEDKILLENYVRS------IENERDTLE 724
N ILK+E KK ++ +K +S+ E++++ + ++S E E + L
Sbjct: 770 FAQLEAENSILKDE-KKTLEDMLKIHTPVSQ--EERLIFLDSIKSKSKDSVWEKEIEILI 826
Query: 725 FEMRHLQREYLSLSDKICNQHN 746
E L+++ + L+++I Q N
Sbjct: 827 EENEDLKQQCIQLNEEIEKQRN 848
Score = 60.5 bits (145), Expect = 6e-09
Identities = 158/805 (19%), Positives = 315/805 (39%), Gaps = 141/805 (17%)
Query: 4 EKQHRE--EDEVDSVLLSASKI------LNSSEGVKESGCSDTEYGCIAESENQIQPQSA 55
EKQ++E E+EV V++S S L+ G KE+ S + + + E +
Sbjct: 1433 EKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMK 1492
Query: 56 LKVLQQQLESFQALRMQTLQNVSMPTENQEEN-----LSMEKSHHFEDSK--TLHSVEEK 108
L Q ++F+ + ++ + ++ E+ LS H +SK L EE
Sbjct: 1493 LSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEM 1552
Query: 109 LSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLP 168
S D + QS IH E +++ ++ L N ++++ Y +
Sbjct: 1553 FSKDKTFIVRQS------IHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATE 1606
Query: 169 TAPPNVMSQADTVILDKS-------KITVPFLKHGFCENLDDICHSIKQMKEEL----QK 217
M Q + D+ ++ + +N + + + + EEL Q
Sbjct: 1607 LLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQL 1666
Query: 218 SHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISE 277
S G L EL+ T +NG + + + KE+ LD ED+ + +S
Sbjct: 1667 SLAGREKLCCELRNSSTQT---QNGNENQGEVEEQTF---KEKELDRK-PEDVPPEILSN 1719
Query: 278 ---------------LEALVKKLLPFRETVSKFHVHFCRKCKK-------LSKSEMHRGK 315
L +VK ET+ + + + K + +SE
Sbjct: 1720 ERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASV 1779
Query: 316 KNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQG----SII 371
K+ + + +T ++I S +PR ++ + E + ++ LV+ G I
Sbjct: 1780 KSCVHEEHTRVTDESIPSYS-GSDMPRNDINMWSKVTEEGTELSQR--LVRSGFAGTEID 1836
Query: 372 SENEK-----TSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLI 426
ENE+ +S++ + E+ + I + L+ + Q ++M E+ K +
Sbjct: 1837 PENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMR---ESFRQKQE----- 1888
Query: 427 FTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNK 486
T+SL +++L+ + E+S + +L+ L + + +I Y K
Sbjct: 1889 -ATESL-----KCQEELRERLHEESRAREQLAVE-------LSKAEGVIDGY----ADEK 1931
Query: 487 TLEEKNIQLSLEKQQMMEALDQ----LKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNI- 541
TL E+ IQ EK +++ L+Q ++ + +++ + E +S + EAMK
Sbjct: 1932 TLFERQIQ---EKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAG 1988
Query: 542 -----LLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQI 596
LL + EK M EK Q EK + + LEI ++ R + EQE
Sbjct: 1989 PVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK---- 2044
Query: 597 IETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNS 656
T L + Q +E+++E ++ + ++ + + E +++
Sbjct: 2045 -----------NTELMDLRQQNQALEKQLEKMRKFLD-------EQAIDREHERDVFQQE 2086
Query: 657 LSEIGKECEMLSKM--VMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVR 714
+ ++ ++ +++ + + E +T E+L H +E + S L K L+ ++
Sbjct: 2087 IQKLEQQLKVVPRFQPISEHQTRE---VEQLANHLKEK---TDKCSELLLSKEQLQRDIQ 2140
Query: 715 SIENERDTLEFEMRHLQREYLSLSD 739
E + LEF +R L++ L +D
Sbjct: 2141 ERNEEIEKLEFRVRELEQALLVSAD 2165
Score = 55.8 bits (133), Expect = 1e-07
Identities = 77/391 (19%), Positives = 159/391 (40%), Gaps = 68/391 (17%)
Query: 412 ESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEF 471
E E LN + + + + T+ L Q+++ +E +K + + + L + E ++EF
Sbjct: 170 EIEELNRELEEMRVTYGTEGL-QQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREF 228
Query: 472 KKIISKYNVLQGQ-----------NKTLEEKNIQLSLEKQQMMEALDQLKSKEH------ 514
++ + LQ Q N T L KQQ++ QL+ ++H
Sbjct: 229 LELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQ 288
Query: 515 KTQSDMAI-------------------VNNENNRMSIEMEAM--KTNILLIQDEKEMLEK 553
K + D + V N N E E + + N +I++EK+ LE
Sbjct: 289 KKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLEL 348
Query: 554 KTH---------QLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEK 604
K +L ++ E+K +LE+ K+KER + E + L+ +E + +K
Sbjct: 349 KDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEEL--QK 406
Query: 605 LNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSE------ASIYKNSLS 658
N + + E+ +++ + ++ ++ +E + Q+I K E A + +
Sbjct: 407 RNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTR 466
Query: 659 EIGKECEMLSKMVMETKTDNQI---------LKEELKKHSQENIKFENSISRLTEDKILL 709
G+ L T ++QI L +L+ + + K + + + E+K L
Sbjct: 467 HKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCAL 526
Query: 710 ENYVRSIENERDTLEFEMRHLQREYLSLSDK 740
+ R +E+ + L F +QR +++++
Sbjct: 527 Q---RQLEDLVEELSFSREQIQRARQTIAEQ 554
Score = 55.5 bits (132), Expect = 2e-07
Identities = 137/722 (18%), Positives = 297/722 (41%), Gaps = 55/722 (7%)
Query: 30 VKESGCS-DTEYGCIAESENQIQPQSALKVLQ-QQLESFQALRMQTLQNVSMPTENQEEN 87
VK +G + + C +E +I Q K+ + Q+L + + L M++ T +E
Sbjct: 2799 VKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHY 2858
Query: 88 LSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNII 147
++++ E+ TL +V + L +S+P+ + S + + S + I
Sbjct: 2859 VAVQLLK--EECGTLKAVIQCLRSKEGSSIPELAH--SDAYQTREICSSDSGSDWGQGIY 2914
Query: 148 IHPSENSDILKNYNNFYRFLPTAP-PNVMSQADTVILDKSKITVPFLKHGFCENLDDICH 206
+ S+ DI T P + + ++ + + + + D H
Sbjct: 2915 LTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGED---H 2971
Query: 207 SIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGK-YDMSPIHQDKMNFIKEENLDGN 265
SI+Q+ E + + + L+ L T + R + YD S H+ ++ E L
Sbjct: 2972 SIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLA-- 3029
Query: 266 LNEDIKSKRI-------SELEAL-----VKKLLPFRETVSKFHVHFCRKCKKLSKSEMHR 313
L + +R +EL AL V L + + + V + + L K++ R
Sbjct: 3030 LQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKAD-RR 3088
Query: 314 GKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDK--ERQPFLVKQGSII 371
+E + G+ IT LK + + L+ + + + E Q L
Sbjct: 3089 SLLSEIQALHAQMNGRKIT-LKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRA 3147
Query: 372 SE-NEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKK-VMELESENLNLKSKMKPLIFTT 429
+E E+ S V + +++ + L+ +++ Q K + ELE+ L +K K +
Sbjct: 3148 TELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLN 3207
Query: 430 QSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLE 489
+L + + + L +EK+ KL ++EE KE L++ K L+ Q +
Sbjct: 3208 DTLASEQKKSRELQWALEKEKA----KLGRSEERDKEELEDLKFS------LESQKQRNL 3257
Query: 490 EKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKE 549
+ N+ L +KQ + E+ +++S+ + ++ N + + +E+ K I + +
Sbjct: 3258 QLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLD 3317
Query: 550 MLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLET 609
E++ H L+ G E + LKE ++ + + +++++ + KL+
Sbjct: 3318 R-ERELHAQLQSSDGTGQSRPPLPSEDL-LKELQKQLEEKHSRIVELLNETEKYKLDSLQ 3375
Query: 610 TLQESTAARQIMEREIENIQTYQSTAEENFLQ---EIKNAKSEASIYKNSLSEIGKECEM 666
T Q+ RQ+ + ++ Q + ++ + ++++ + + + + ++ E +
Sbjct: 3376 TRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQR 3435
Query: 667 LSKMVMETKTDNQILKEELKKHSQ----ENIKFENSISRLTEDKILLENYVRSIENERDT 722
L ++ E + Q L+ E K+ S+ +N+ E + LT D+ N+V + E +T
Sbjct: 3436 LQGIMQEFQ--KQELEREEKRESRRILYQNLN-EPTTWSLTSDR--TRNWVLQQKIEGET 3490
Query: 723 LE 724
E
Sbjct: 3491 KE 3492
Score = 53.5 bits (127), Expect = 7e-07
Identities = 146/805 (18%), Positives = 302/805 (37%), Gaps = 157/805 (19%)
Query: 4 EKQHREEDEVDSVLLSASKILNSSEGVKESGCSDT------EYGCIAESENQIQPQSALK 57
EK E++ LL ++ E K G + E AE + + + +
Sbjct: 2147 EKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEIT 2206
Query: 58 VLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSL 117
L++QLE F+ + L+N + + L ++K + L E KL D + L
Sbjct: 2207 NLEEQLEQFR----EELENKNEEVQQLHMQLEIQKKESTTRLQELEQ-ENKLFKDDMEKL 2261
Query: 118 PQSVNVPSQIHSEDTLTL-----------RTSTDNLSSNII-----IHPSENSDILKNYN 161
++ + ++D L D L+ + + + ++ +++ N
Sbjct: 2262 GLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKN 2321
Query: 162 NFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEEL----QK 217
R L T +MS + V ++ E ++ + I+++++EL QK
Sbjct: 2322 ELIRDLETQIECLMSDQECVKRNRE------------EEIEQLNEVIEKLQQELANIGQK 2369
Query: 218 SHDGEVALTNELQTLQTDPDVHRNGKYDMSP---IHQDKMNFIKEENLDGNLNEDIKSKR 274
+ +L+ E +L+ DV K + ++M F+K + N +
Sbjct: 2370 TSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNF-------K 2422
Query: 275 ISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDL 334
+++L + L RE+V K + IP N+
Sbjct: 2423 MNQLTQELFSLKRERESVEKI--------------------------QSIPENSVNVAID 2456
Query: 335 KFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYL 394
P + T+ +K E Q + EN K S +N T
Sbjct: 2457 HLSKDKPELEVVL---TEDALKSLENQTYFKS----FEENGKGSIINLETR--------- 2500
Query: 395 QNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQ 454
L+ + K +EL +K + F T+ L +K+ +K ++ V Q
Sbjct: 2501 --LLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQ 2558
Query: 455 SKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEH 514
+L +EY+K C N+T+ + + +++ L+QL +E
Sbjct: 2559 IQLEAVQEYAKFC---------------QDNQTISSEPERTNIQN------LNQL--RED 2595
Query: 515 KTQSDMAIVNNENNRMSIEMEAMKTNILLIQD-----EKEMLEKKTHQLLKEKSSLGNEL 569
+ SD++ + + + ++ M T+++L ++ EK +LEK+ L +K GNE
Sbjct: 2596 ELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEK 2655
Query: 570 KESQLEIIQLKEKERLAKT--------EQETLLQIIETVKDEKLNLETTLQESTAARQIM 621
K+ + E + + + KT E+ +E ++ E + + L + +
Sbjct: 2656 KQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKL 2715
Query: 622 EREIENIQTYQSTAEENFLQ---EIKNAKSEASIY----KNSLSEIGKECEM------LS 668
+ E+ +T ++ +++ Q + AK + SI + + E K C LS
Sbjct: 2716 QEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLS 2775
Query: 669 KMV-------METKTDNQILKEELKKHS-QENIKFENSISRLTEDKILLENYVRSIENER 720
K + ++ + NQ + +K Q N++ E S +TE ++ + IE +
Sbjct: 2776 KSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTE---IISQFTEKIEKMQ 2832
Query: 721 DTLEFEMRHLQREYLSLSDKICNQH 745
+ E+ ++ ++S ++ + +H
Sbjct: 2833 ELHAAEILDMESRHISETETLKREH 2857
Score = 46.2 bits (108), Expect = 1e-04
Identities = 67/317 (21%), Positives = 146/317 (46%), Gaps = 44/317 (13%)
Query: 430 QSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLE 489
+SL+ +++ Q+ K T++ + ++E+ S+E L+ YN+ Q Q++ LE
Sbjct: 3088 RSLLSEIQALHAQMNG---RKITLKRE-QESEKPSQELLE--------YNIQQKQSQMLE 3135
Query: 490 EKNIQLSLEKQQMMEALDQL----------KSKEHKTQSDMAIVNNENNRMSIEMEAMKT 539
+ ++LS K + E +QL KS+ +T+ ++ ++ E+EA +
Sbjct: 3136 MQ-VELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRL 3194
Query: 540 NILLIQDEKEMLEKKTHQLLKEKSSLGNELKES-QLEIIQLKEKERLAKTEQETLLQIIE 598
+ DE +L +L +E K+S +L+ KEK +L ++E+ E
Sbjct: 3195 EVKDKTDEVHLL----------NDTLASEQKKSRELQWALEKEKAKLGRSEERDK----E 3240
Query: 599 TVKDEKLNLETTLQESTAARQIMEREIENI-QTYQSTAEENFLQEIKNAKSEASIYKNSL 657
++D K +LE+ Q + ++E++ + + ++ Q + L + + ++ + + +
Sbjct: 3241 ELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQV 3300
Query: 658 ---SEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVR 714
SE + EM S + E + Q+ + S+ + E+ + L K L E + R
Sbjct: 3301 LLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKEL--QKQLEEKHSR 3358
Query: 715 SIENERDTLEFEMRHLQ 731
+E +T ++++ LQ
Sbjct: 3359 IVELLNETEKYKLDSLQ 3375
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 76.3 bits (186), Expect = 1e-13
Identities = 161/819 (19%), Positives = 322/819 (39%), Gaps = 152/819 (18%)
Query: 43 IAESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMPT------ENQEENLSMEKSHHF 96
+ + ENQ Q ++ LQ +L + L Q+ S T E EEN + H
Sbjct: 217 VVQEENQ-HMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHE 275
Query: 97 EDSKTLHSVEEKLSG---------DSVNSLPQSVNVPSQIHSEDTLTLRTSTDN------ 141
+K L + + L ++N+ +S+ ++ L+ + + ++
Sbjct: 276 RQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRR 335
Query: 142 -LSSNIIIHPSENSDILKNYNN------FYRFLPTAPPNVMSQADTVILDKSKITVPFLK 194
+ + +H E+ K N +R AP + ++A +++ + ++
Sbjct: 336 LAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSME 395
Query: 195 HGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRN-GKYDMSPIHQDK 253
G ++ ++EE+Q T E + +V+R+ K+ + I Q K
Sbjct: 396 RG-----------LRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVK 444
Query: 254 MNFIKEEN--------LDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKK 305
+++ L+ N+ SK+ +E L + L + + +
Sbjct: 445 QELSRKDTELLALQTKLETLTNQFSDSKQ--HIEVLKESLTAKEQRAAILQTEVDALRLR 502
Query: 306 LSKSEMHRGKKNEKNN---KEIPITGKNITDLKFHSRVPRYTLSFL----DQTKHEMKDK 358
L + E KK ++ +E I DLK V ++ L + + +++DK
Sbjct: 503 LEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDK 562
Query: 359 ERQPFLVKQG--SIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENL 416
E+Q +K+ S+ ++ T + E+ +A+ + LKE Q+ E E +
Sbjct: 563 EKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKE----QRDRDEREKQ-- 616
Query: 417 NLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIIS 476
++++ Y+K LK+L E+ S +Q LS+ E + + + S
Sbjct: 617 -----------------EEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLAS 659
Query: 477 KYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEA 536
+ KTLE I L +K++ ++ QLK K H+ A+ + MS ++
Sbjct: 660 SGLKKDSRLKTLE---IALEQKKEECLKMESQLK-KAHEA----ALEARASPEMSDRIQH 711
Query: 537 MKTNILLIQDEKEMLEKKTHQLL--------------KEKSSLGNELKESQLEIIQLKEK 582
++ I +DE + + +LL K+ + L ++K+ ++ LK K
Sbjct: 712 LEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHK 771
Query: 583 ERLAKTEQETLL---------------QIIETV--KDEKL-NLETTLQES---TAARQIM 621
E++ K + +L Q+ +++ KD+++ LE L+ES TA R+++
Sbjct: 772 EQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMV 831
Query: 622 EREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQIL 681
+ E+ +T E L ++ K E K LS + + E +T L
Sbjct: 832 LAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSS-------TQQSLAEKETHLTNL 884
Query: 682 KEELKKHSQENIKFEN-----SISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLS 736
+ E +KH +E ++ + +IS + LLE + + + + E+ L+RE
Sbjct: 885 RAERRKHLEEVLEMKQEALLAAISEKDANIALLE-----LSSSKKKTQEEVAALKRE--- 936
Query: 737 LSDKICNQHNDPSKTTYISRREKFHFDNYTHEDTSSPQS 775
D++ Q ++ R K DNY + S S
Sbjct: 937 -KDRLVQQLKQQTQ-----NRMKLMADNYEDDHFKSSHS 969
Score = 51.2 bits (121), Expect = 4e-06
Identities = 121/615 (19%), Positives = 245/615 (39%), Gaps = 71/615 (11%)
Query: 1 MSPEKQHRE-EDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVL 59
M E+ HR E+ DS + +K L + +K+S S E G + + E +IQ + L
Sbjct: 359 MLREEMHRRFENAPDS---AKTKALQTVIEMKDSKISSMERG-LRDLEEEIQMLKSNGAL 414
Query: 60 QQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQ 119
+ + +M+ ++ S +N+ + E S + L + E L+ +S
Sbjct: 415 STEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQH 474
Query: 120 SVNVPSQIHSED--TLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQ 177
+ + +++ L+T D L + + + K + T +
Sbjct: 475 IEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDL 534
Query: 178 ADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPD 237
D + + + K+ V + I+ ++E+L+ +L +++LQ D
Sbjct: 535 KDMLDVKERKVNV-------------LQKKIENLQEQLRDKEKQMSSLKERVKSLQADTT 581
Query: 238 VHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHV 297
+ +K I E L + D + K+ E++ K L +E VS
Sbjct: 582 NTDTALTTLEEALAEKERTI--ERLKEQRDRDEREKQ-EEIDNYKKDLKDLKEKVSLLQG 638
Query: 298 HFCRK------CKKLSKSEMHRGKKNEKNNK--EIPITGKNITDLKFHSRVPRYTLSFLD 349
K K+ + S G K + K EI + K LK S++ + + L+
Sbjct: 639 DLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALE 698
Query: 350 -QTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKV 408
+ EM D+ + + I +++SK + ++ + ++ ++N E KK+
Sbjct: 699 ARASPEMSDRIQH----LEREITRYKDESSKAQAEVDRLLEILKEVEN---EKNDKDKKI 751
Query: 409 MELESENLNLKSKMKPLIFTTQ----SLIQKVETYEKQLKNLVEEKSTIQSKLSKTE--- 461
ELE + + K+ L Q Q +E ++ NL + +Q L K +
Sbjct: 752 AELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRI 811
Query: 462 EYSKECLKEFKKIISKYNVLQGQN---KTLEEKNIQ-LSLEKQQMMEALDQLKSKEHKTQ 517
E +E L+E +I ++ ++ Q +T EK ++ L + +++ + L+ +K+K TQ
Sbjct: 812 EELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQ 871
Query: 518 SDMA-----IVNNENNR-------MSIEMEAM-------KTNILLIQ--DEKEMLEKKTH 556
+A + N R + ++ EA+ NI L++ K+ +++
Sbjct: 872 QSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVA 931
Query: 557 QLLKEKSSLGNELKE 571
L +EK L +LK+
Sbjct: 932 ALKREKDRLVQQLKQ 946
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 76.3 bits (186), Expect = 1e-13
Identities = 157/773 (20%), Positives = 317/773 (41%), Gaps = 108/773 (13%)
Query: 19 SASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQQLESFQALRMQTLQNVS 78
S K SSE +K+ + E ++Q + ++ Q+ + LR + +
Sbjct: 383 SKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYG 442
Query: 79 MPTENQEENLSMEKSHHFEDSKTLHSVEEK----------LSGDSVNSLPQSVNVPSQIH 128
++ L + E+ KT H E + ++ D + + ++N I
Sbjct: 443 QQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAIN-ELNIK 501
Query: 129 SEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKI 188
+DT + + L + + E + + + L + + T+ +SK+
Sbjct: 502 LQDT---NSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKL 558
Query: 189 TVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTN---ELQTLQTDPDVHRNGKYD 245
E+L S + ++EL+ H+ EV TN +L+ L+ + + + +
Sbjct: 559 NEAHKSLSTVEDLKAEIVSASESRKELELKHEAEV--TNYKIKLEMLEKEKNAVLDRMAE 616
Query: 246 MSPIHQDKMN----FIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCR 301
+++ F EE L L ED++ + +E L L +H+ +
Sbjct: 617 SQEAELERLRTQLLFSHEEELS-KLKEDLEIEHRINIEKLKDNL----------GIHYKQ 665
Query: 302 KCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQ 361
+ L ++EM + + + K+ IT +N L+ S++ S ++ EM + +
Sbjct: 666 QIDGL-QNEMSQKIETMQFEKDNLITKQNQLILEI-SKLKDLQQSLVNSKSEEMTLQINE 723
Query: 362 PFLVKQGSIISENEKTS-KVNSVTEQCVAKIQYLQNYLKESVQ-IQKKVMELESENLNLK 419
L K+ I+ + EK + ++ K + L+ +KE +Q+K +LE+EN LK
Sbjct: 724 --LQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILK 781
Query: 420 SKMKPL-----IFTTQSLIQKV---ETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEF 471
+ K L I T S +++ ++ + + K+ V EK I+ + + E+ ++C++
Sbjct: 782 DEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKE-IEILIEENEDLKQQCIQLN 840
Query: 472 KKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQ----SDMAIVNNEN 527
++I + N K E +L E +++ D L+ ++K + S + +N E
Sbjct: 841 EEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL 900
Query: 528 NRMSIEMEAMKTNILLIQDEK----------EMLEKKTHQLL-------KEK-------S 563
+ I +K + ++K E++EK T +L+ +EK S
Sbjct: 901 HLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS 960
Query: 564 SLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMER 623
L +LK+ EI L E+ + K E+ E V LE + + A
Sbjct: 961 DLSEQLKQKHGEISFLNEEVKSLKQEK-------EQVSLRCRELEIIINHNRA------- 1006
Query: 624 EIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKT--DNQIL 681
EN+Q+ T + L + S + + S+S++ K SK+++E K +N +
Sbjct: 1007 --ENVQSC-DTQVSSLLDGVVTMTSRGA--EGSVSKVNKSFGEESKIMVEDKVSFENMTV 1061
Query: 682 KEELKKHSQENIKFENSISRLTEDKILLENYVRSIE-NERDTLEFEMRHLQRE 733
EE K QE + ++ S + E+ +R+ + +E D L+ E+ L+ E
Sbjct: 1062 GEESK---QEQLILDHLPS------VTKESSLRATQPSENDKLQKELNVLKSE 1105
Score = 76.3 bits (186), Expect = 1e-13
Identities = 116/554 (20%), Positives = 241/554 (43%), Gaps = 75/554 (13%)
Query: 202 DDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEEN 261
DD+ +K ++ ++++ + L E T D R + + F+ E+
Sbjct: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDL---RQQNQALEKQLEKMRKFLDEQA 2073
Query: 262 LDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKK----- 316
+D D+ + I +LE +K ++P + +S+ H R+ ++L+ + K
Sbjct: 2074 IDREHERDVFQQEIQKLEQQLK-VVPRFQPISE---HQTREVEQLANHLKEKTDKCSELL 2129
Query: 317 --NEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISEN 374
E+ ++I + I L+F RV + L + + E +P L + + +E
Sbjct: 2130 LSKEQLQRDIQERNEEIEKLEF--RVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAER 2187
Query: 375 E----KTSKVNSVTEQCVAKIQYLQNYLKE------SVQIQKK-----VMELESENLNLK 419
+ K ++ ++ EQ + L+N +E ++IQKK + ELE EN K
Sbjct: 2188 DAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFK 2247
Query: 420 SKMKPLIFTTQSLIQKVETYEKQLKNLVEEK--STIQSKLSKTEEYSKEC--LKEFKKII 475
M+ L I++ + Q ++++ K IQ K + ++ +++ L++ KI
Sbjct: 2248 DDMEKLGLA----IKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKIT 2303
Query: 476 SKYNVLQGQNKTLEEKNIQLSL-------EKQQMMEALDQLKSKEHKTQSDMAIVNNENN 528
+ V++ +N+ + + Q+ K+ E ++QL K Q ++A + + +
Sbjct: 2304 TDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTS 2363
Query: 529 R----MSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKER 584
+S E +++K + ++ EK LE++ +E + + N LKE+ ++ QL ++
Sbjct: 2364 MNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELF 2423
Query: 585 LAKTEQETLLQI-----------IETVKDEKLNLETTLQESTAARQIMEREIENIQTYQS 633
K E+E++ +I I+ + +K LE L E + +EN QTY
Sbjct: 2424 SLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDAL------KSLEN-QTYFK 2476
Query: 634 TAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENI 693
+ EEN I N ++ ++++S E K + + + Q E L+K
Sbjct: 2477 SFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQK------ 2530
Query: 694 KFENSISRLTEDKI 707
K N + ++ E+K+
Sbjct: 2531 KIVN-LQKIVEEKV 2543
Score = 65.9 bits (159), Expect = 1e-10
Identities = 149/833 (17%), Positives = 334/833 (40%), Gaps = 134/833 (16%)
Query: 12 EVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQQLESFQALRM 71
E +S L A K L++ E +K S +E + E +++ ++ + + +LE + +
Sbjct: 553 EQESKLNEAHKSLSTVEDLKAEIVSASE----SRKELELKHEAEVTNYKIKLEMLEKEKN 608
Query: 72 QTLQNVSMPTENQEENLSMEK--SHHFEDSKTLHSVE-------EKLSGDSVNSLPQSVN 122
L ++ E + E L + SH E SK +E EKL + Q ++
Sbjct: 609 AVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQID 668
Query: 123 VPSQIHSEDTLTLRTSTDNL---SSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQAD 179
S+ T++ DNL + +I+ S+ D+ ++ N T N + +
Sbjct: 669 GLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEI 728
Query: 180 TVILDKSK-------------ITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALT 226
++ + K + L+ E +D+ Q++ E L
Sbjct: 729 EILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAE-------NSILK 781
Query: 227 NELQTLQTDPDVHRNGKYDMSPIHQDK----MNFIKEENLDG----------NLNEDIKS 272
+E +TL+ +H +P+ Q++ ++ IK ++ D NED+K
Sbjct: 782 DEKKTLEDMLKIH-------TPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQ 834
Query: 273 KRISELEALVKKLLPFRETVSKFHVHFCRKCKKLS--------------KSEMHRGKKNE 318
+ I E + K+ F F V++ ++ + K E+ K +
Sbjct: 835 QCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLK 894
Query: 319 KNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEK-- 376
N+E+ + N T +K S V +F+ +T + E+ + + +++ EK
Sbjct: 895 ALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLE 954
Query: 377 -TSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQK 435
+ +++ ++EQ K + ++L E V K ++ E E ++L+ + +I + +
Sbjct: 955 LSQRLSDLSEQLKQKHGEI-SFLNEEV----KSLKQEKEQVSLRCRELEIIIN-HNRAEN 1008
Query: 436 VETYEKQLKNLVEEKSTIQSKLSK--TEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNI 493
V++ + Q+ +L++ T+ S+ ++ + +K +E K ++ + E K
Sbjct: 1009 VQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQE 1068
Query: 494 QLSLEKQQMMEALDQLK----SKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLI----- 544
QL L+ + L+ S+ K Q ++ ++ +E N + ++MEA + + L+
Sbjct: 1069 QLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHV 1128
Query: 545 ---------QDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKE------------ 583
+ +K + K + ++ + K QLE+ +K +E
Sbjct: 1129 DQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLI 1188
Query: 584 -RLAKTEQE-------TLLQIIETVKDEKLNLETTLQE-STAARQIMEREIENIQTYQST 634
+L K E TL ++ L E ++ + I E E +Q Y+
Sbjct: 1189 GKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYE 1248
Query: 635 AEE------NFLQEIKNAKSEASIYKNSLSEI------GKECEMLSKMVMETKTDNQILK 682
++ L ++ ++ + + LS+I G + E + + + +T+ +
Sbjct: 1249 VQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIH 1308
Query: 683 EELKKHSQENIKFENSISRLTE-DKILLENYVRSIENERDTLEFEMRHLQREY 734
++ ++ ++ +S L + +K LE V+ +E+ +L+ +++ ++ Y
Sbjct: 1309 SQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361
Score = 62.8 bits (151), Expect = 1e-09
Identities = 108/562 (19%), Positives = 240/562 (42%), Gaps = 98/562 (17%)
Query: 258 KEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKN 317
+++ ++ + E+I+ K + +E L K++ + + K L + + +KN
Sbjct: 312 QDKKVENSNKEEIQEKE-TIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKN 370
Query: 318 EK-NNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEK 376
++ N ++ +T + + + + + + K KD + + +V++ E E
Sbjct: 371 QEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQR----MEQET 426
Query: 377 TSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLN-LKSKMKPLIFTTQSLIQK 435
K+ EQ A++ + Y ++ VQ++++++ + +K++ K +
Sbjct: 427 QRKL----EQLRAELDEM--YGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSN 480
Query: 436 VETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQL 495
+ E Q+K + + + KL T ++ +E I+ + LQ Q + L E +L
Sbjct: 481 ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVE---EL 537
Query: 496 SLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKK- 554
S ++Q+ A + +E K NE ++ +E +K I+ + ++ LE K
Sbjct: 538 SFSREQIQRARQTIAEQESKL--------NEAHKSLSTVEDLKAEIVSASESRKELELKH 589
Query: 555 ----------THQLLKEKSSLGNELKESQ-LEIIQLK------EKERLAKTE-------- 589
L KEK+++ + + ESQ E+ +L+ +E L+K +
Sbjct: 590 EAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHR 649
Query: 590 ---------------------QETLLQIIETVKDEKLNLETTLQE---STAARQIMEREI 625
Q + Q IET++ EK NL T + + + +++ +
Sbjct: 650 INIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSL 709
Query: 626 ENIQTYQSTAEENFLQE----IKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTD---- 677
N ++ + T + N LQ+ ++ + E + + E+ + E+L K + E + D
Sbjct: 710 VNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEK 769
Query: 678 -------NQILKEELKKHSQENIKFENSISRLTEDKILLENYVRS------IENERDTLE 724
N ILK+E KK ++ +K +S+ E++++ + ++S E E + L
Sbjct: 770 FAQLEAENSILKDE-KKTLEDMLKIHTPVSQ--EERLIFLDSIKSKSKDSVWEKEIEILI 826
Query: 725 FEMRHLQREYLSLSDKICNQHN 746
E L+++ + L+++I Q N
Sbjct: 827 EENEDLKQQCIQLNEEIEKQRN 848
Score = 59.3 bits (142), Expect = 1e-08
Identities = 157/801 (19%), Positives = 313/801 (39%), Gaps = 141/801 (17%)
Query: 4 EKQHRE--EDEVDSVLLSASKI------LNSSEGVKESGCSDTEYGCIAESENQIQPQSA 55
EKQ++E E+EV V++S S L+ G KE+ S + + + E +
Sbjct: 1433 EKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMK 1492
Query: 56 LKVLQQQLESFQALRMQTLQNVSMPTENQEEN-----LSMEKSHHFEDSK--TLHSVEEK 108
L Q ++F+ + ++ + ++ E+ LS H +SK L EE
Sbjct: 1493 LSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEM 1552
Query: 109 LSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLP 168
S D + QS IH E +++ ++ L N ++++ Y +
Sbjct: 1553 FSKDKTFIVRQS------IHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATE 1606
Query: 169 TAPPNVMSQADTVILDKS-------KITVPFLKHGFCENLDDICHSIKQMKEEL----QK 217
M Q + D+ ++ + +N + + + + EEL Q
Sbjct: 1607 LLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQL 1666
Query: 218 SHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISE 277
S G L EL+ T +NG + + + KE+ LD ED+ + +S
Sbjct: 1667 SLAGREKLCCELRNSSTQT---QNGNENQGEVEEQTF---KEKELDRK-PEDVPPEILSN 1719
Query: 278 ---------------LEALVKKLLPFRETVSKFHVHFCRKCKK-------LSKSEMHRGK 315
L +VK ET+ + + + K + +SE
Sbjct: 1720 ERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASV 1779
Query: 316 KNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQG----SII 371
K+ + + +T ++I S +PR ++ + E + ++ LV+ G I
Sbjct: 1780 KSCVHEEHTRVTDESIPSYS-GSDMPRNDINMWSKVTEEGTELSQR--LVRSGFAGTEID 1836
Query: 372 SENEK-----TSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLI 426
ENE+ +S++ + E+ + I + L+ + Q ++M E+ K +
Sbjct: 1837 PENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMR---ESFRQKQE----- 1888
Query: 427 FTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNK 486
T+SL +++L+ + E+S + +L+ L + + +I Y K
Sbjct: 1889 -ATESL-----KCQEELRERLHEESRAREQLAVE-------LSKAEGVIDGY----ADEK 1931
Query: 487 TLEEKNIQLSLEKQQMMEALDQ----LKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNI- 541
TL E+ IQ EK +++ L+Q ++ + +++ + E +S + EAMK
Sbjct: 1932 TLFERQIQ---EKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAG 1988
Query: 542 -----LLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQI 596
LL + EK M EK Q EK + + LEI ++ R + EQE
Sbjct: 1989 PVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK---- 2044
Query: 597 IETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNS 656
T L + Q +E+++E ++ + ++ + + E +++
Sbjct: 2045 -----------NTELMDLRQQNQALEKQLEKMRKFLD-------EQAIDREHERDVFQQE 2086
Query: 657 LSEIGKECEMLSKM--VMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVR 714
+ ++ ++ +++ + + E +T E+L H +E + S L K L+ ++
Sbjct: 2087 IQKLEQQLKVVPRFQPISEHQTRE---VEQLANHLKEK---TDKCSELLLSKEQLQRDIQ 2140
Query: 715 SIENERDTLEFEMRHLQREYL 735
E + LEF +R L++ L
Sbjct: 2141 ERNEEIEKLEFRVRELEQALL 2161
Score = 55.8 bits (133), Expect = 1e-07
Identities = 77/391 (19%), Positives = 159/391 (40%), Gaps = 68/391 (17%)
Query: 412 ESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEF 471
E E LN + + + + T+ L Q+++ +E +K + + + L + E ++EF
Sbjct: 170 EIEELNRELEEMRVTYGTEGL-QQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREF 228
Query: 472 KKIISKYNVLQGQ-----------NKTLEEKNIQLSLEKQQMMEALDQLKSKEH------ 514
++ + LQ Q N T L KQQ++ QL+ ++H
Sbjct: 229 LELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQ 288
Query: 515 KTQSDMAI-------------------VNNENNRMSIEMEAM--KTNILLIQDEKEMLEK 553
K + D + V N N E E + + N +I++EK+ LE
Sbjct: 289 KKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLEL 348
Query: 554 KTH---------QLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEK 604
K +L ++ E+K +LE+ K+KER + E + L+ +E + +K
Sbjct: 349 KDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEEL--QK 406
Query: 605 LNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSE------ASIYKNSLS 658
N + + E+ +++ + ++ ++ +E + Q+I K E A + +
Sbjct: 407 RNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTR 466
Query: 659 EIGKECEMLSKMVMETKTDNQI---------LKEELKKHSQENIKFENSISRLTEDKILL 709
G+ L T ++QI L +L+ + + K + + + E+K L
Sbjct: 467 HKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCAL 526
Query: 710 ENYVRSIENERDTLEFEMRHLQREYLSLSDK 740
+ R +E+ + L F +QR +++++
Sbjct: 527 Q---RQLEDLVEELSFSREQIQRARQTIAEQ 554
Score = 55.5 bits (132), Expect = 2e-07
Identities = 137/722 (18%), Positives = 297/722 (41%), Gaps = 55/722 (7%)
Query: 30 VKESGCS-DTEYGCIAESENQIQPQSALKVLQ-QQLESFQALRMQTLQNVSMPTENQEEN 87
VK +G + + C +E +I Q K+ + Q+L + + L M++ T +E
Sbjct: 2791 VKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHY 2850
Query: 88 LSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNII 147
++++ E+ TL +V + L +S+P+ + S + + S + I
Sbjct: 2851 VAVQLLK--EECGTLKAVIQCLRSKEGSSIPELAH--SDAYQTREICSSDSGSDWGQGIY 2906
Query: 148 IHPSENSDILKNYNNFYRFLPTAP-PNVMSQADTVILDKSKITVPFLKHGFCENLDDICH 206
+ S+ DI T P + + ++ + + + + D H
Sbjct: 2907 LTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGED---H 2963
Query: 207 SIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGK-YDMSPIHQDKMNFIKEENLDGN 265
SI+Q+ E + + + L+ L T + R + YD S H+ ++ E L
Sbjct: 2964 SIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLA-- 3021
Query: 266 LNEDIKSKRI-------SELEAL-----VKKLLPFRETVSKFHVHFCRKCKKLSKSEMHR 313
L + +R +EL AL V L + + + V + + L K++ R
Sbjct: 3022 LQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKAD-RR 3080
Query: 314 GKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDK--ERQPFLVKQGSII 371
+E + G+ IT LK + + L+ + + + E Q L
Sbjct: 3081 SLLSEIQALHAQMNGRKIT-LKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRA 3139
Query: 372 SE-NEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKK-VMELESENLNLKSKMKPLIFTT 429
+E E+ S V + +++ + L+ +++ Q K + ELE+ L +K K +
Sbjct: 3140 TELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLN 3199
Query: 430 QSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLE 489
+L + + + L +EK+ KL ++EE KE L++ K L+ Q +
Sbjct: 3200 DTLASEQKKSRELQWALEKEKA----KLGRSEERDKEELEDLKFS------LESQKQRNL 3249
Query: 490 EKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKE 549
+ N+ L +KQ + E+ +++S+ + ++ N + + +E+ K I + +
Sbjct: 3250 QLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLD 3309
Query: 550 MLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLET 609
E++ H L+ G E + LKE ++ + + +++++ + KL+
Sbjct: 3310 R-ERELHAQLQSSDGTGQSRPPLPSEDL-LKELQKQLEEKHSRIVELLNETEKYKLDSLQ 3367
Query: 610 TLQESTAARQIMEREIENIQTYQSTAEENFLQ---EIKNAKSEASIYKNSLSEIGKECEM 666
T Q+ RQ+ + ++ Q + ++ + ++++ + + + + ++ E +
Sbjct: 3368 TRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQR 3427
Query: 667 LSKMVMETKTDNQILKEELKKHSQ----ENIKFENSISRLTEDKILLENYVRSIENERDT 722
L ++ E + Q L+ E K+ S+ +N+ E + LT D+ N+V + E +T
Sbjct: 3428 LQGIMQEFQ--KQELEREEKRESRRILYQNLN-EPTTWSLTSDR--TRNWVLQQKIEGET 3482
Query: 723 LE 724
E
Sbjct: 3483 KE 3484
Score = 52.0 bits (123), Expect = 2e-06
Identities = 137/759 (18%), Positives = 288/759 (37%), Gaps = 151/759 (19%)
Query: 44 AESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLH 103
AE + + + + L++QLE F+ + L+N + + L ++K + L
Sbjct: 2185 AERDAIDRKEKEITNLEEQLEQFR----EELENKNEEVQQLHMQLEIQKKESTTRLQELE 2240
Query: 104 SVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTL-----------RTSTDNLSSNII----- 147
E KL D + L ++ + ++D L D L+ +
Sbjct: 2241 Q-ENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQ 2299
Query: 148 IHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHS 207
+ + ++ +++ N R L T +MS + V ++ E ++ +
Sbjct: 2300 LKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNRE------------EEIEQLNEV 2347
Query: 208 IKQMKEEL----QKSHDGEVALTNELQTLQTDPDVHRNGKYDMSP---IHQDKMNFIKEE 260
I+++++EL QK+ +L+ E +L+ DV K + ++M F+K
Sbjct: 2348 IEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNV 2407
Query: 261 NLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKN 320
+ N ++++L + L RE+V K
Sbjct: 2408 LKETNF-------KMNQLTQELFSLKRERESVEKI------------------------- 2435
Query: 321 NKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKV 380
+ IP N+ P + T+ +K E Q + EN K S +
Sbjct: 2436 -QSIPENSVNVAIDHLSKDKPELEVVL---TEDALKSLENQTYFKS----FEENGKGSII 2487
Query: 381 NSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYE 440
N T L+ + K +EL +K + F T+ L +K+ +
Sbjct: 2488 NLETR-----------LLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQ 2536
Query: 441 KQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQ 500
K ++ V Q +L +EY+K C N+T+ + + +++
Sbjct: 2537 KIVEEKVAAALVSQIQLEAVQEYAKFC---------------QDNQTISSEPERTNIQN- 2580
Query: 501 QMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQD-----EKEMLEKKT 555
L+QL +E + SD++ + + + ++ M T+++L ++ EK +LEK+
Sbjct: 2581 -----LNQL--REDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEK 2633
Query: 556 HQLLKEKSSLGNELKESQLEIIQLKEKERLAKT--------EQETLLQIIETVKDEKLNL 607
L +K GNE K+ + E + + + KT E+ +E ++ E +
Sbjct: 2634 KLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVAT 2693
Query: 608 ETTLQESTAARQIMEREIENIQTYQSTAEENFLQ---EIKNAKSEASIY----KNSLSEI 660
+ L + ++ E+ +T ++ +++ Q + AK + SI + + E
Sbjct: 2694 KAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQES 2753
Query: 661 GKECEM------LSKMV-------METKTDNQILKEELKKHS-QENIKFENSISRLTEDK 706
K C LSK + ++ + NQ + +K Q N++ E S +TE
Sbjct: 2754 KKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTE-- 2811
Query: 707 ILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQH 745
++ + IE ++ E+ ++ ++S ++ + +H
Sbjct: 2812 -IISQFTEKIEKMQELHAAEILDMESRHISETETLKREH 2849
Score = 46.2 bits (108), Expect = 1e-04
Identities = 67/317 (21%), Positives = 146/317 (46%), Gaps = 44/317 (13%)
Query: 430 QSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLE 489
+SL+ +++ Q+ K T++ + ++E+ S+E L+ YN+ Q Q++ LE
Sbjct: 3080 RSLLSEIQALHAQMNG---RKITLKRE-QESEKPSQELLE--------YNIQQKQSQMLE 3127
Query: 490 EKNIQLSLEKQQMMEALDQL----------KSKEHKTQSDMAIVNNENNRMSIEMEAMKT 539
+ ++LS K + E +QL KS+ +T+ ++ ++ E+EA +
Sbjct: 3128 MQ-VELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRL 3186
Query: 540 NILLIQDEKEMLEKKTHQLLKEKSSLGNELKES-QLEIIQLKEKERLAKTEQETLLQIIE 598
+ DE +L +L +E K+S +L+ KEK +L ++E+ E
Sbjct: 3187 EVKDKTDEVHLL----------NDTLASEQKKSRELQWALEKEKAKLGRSEERDK----E 3232
Query: 599 TVKDEKLNLETTLQESTAARQIMEREIENI-QTYQSTAEENFLQEIKNAKSEASIYKNSL 657
++D K +LE+ Q + ++E++ + + ++ Q + L + + ++ + + +
Sbjct: 3233 ELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQV 3292
Query: 658 ---SEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVR 714
SE + EM S + E + Q+ + S+ + E+ + L K L E + R
Sbjct: 3293 LLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKEL--QKQLEEKHSR 3350
Query: 715 SIENERDTLEFEMRHLQ 731
+E +T ++++ LQ
Sbjct: 3351 IVELLNETEKYKLDSLQ 3367
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 76.3 bits (186), Expect = 1e-13
Identities = 87/424 (20%), Positives = 187/424 (44%), Gaps = 52/424 (12%)
Query: 354 EMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELES 413
E KD + F K S+ +E + S S E +AK++ L+ V+ Q++ ++ ++
Sbjct: 1503 EEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQA 1562
Query: 414 ENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEE----KSTIQSKLSKTEEYSKECLK 469
+ + + K + + + +T+ K++++ EE + + Q KL + E +E +
Sbjct: 1563 GTIQMLEQAK--LRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYE 1620
Query: 470 EFKKIISKYNVLQGQNKTLE----------EKNIQLSLEKQQMMEA-------------- 505
+ +K++ + L+G+ TL EK ++ L++ + + A
Sbjct: 1621 DKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAP 1680
Query: 506 ----LDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKE 561
+ QLK++ +++ A M +E+E + I I K LE++ +L +E
Sbjct: 1681 SKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQRE 1740
Query: 562 KSSLGNELKESQLEIIQLKEKERLAKTE-QETLLQI------IETVKDEKLNLETTLQ-- 612
K+ + N L+E Q ++ +L +K + A + L QI +E EK L+ LQ
Sbjct: 1741 KNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQAL 1800
Query: 613 --------ESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKEC 664
+S + ++ R+ I+ ++ E Q +K +S AS K ++ ++ +E
Sbjct: 1801 QSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQ-VKRLESLASRLKENMEKLTEER 1859
Query: 665 EMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLE 724
+ K N+ L+ +L+ +E + + + K LE + S+E +L+
Sbjct: 1860 DQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQ 1919
Query: 725 FEMR 728
+++
Sbjct: 1920 ADLK 1923
Score = 55.1 bits (131), Expect = 3e-07
Identities = 90/427 (21%), Positives = 178/427 (41%), Gaps = 73/427 (17%)
Query: 374 NEKTSKVNSVTEQCVAKIQYLQNYLKESVQ------IQKKVMELESENLNLKSKMKPLIF 427
+E+TS+ ++ + Q++ K +Q +QK + +N +K +F
Sbjct: 1185 DEQTSRNLTLFQAACRGYLARQHFKKRKIQDLAIRCVQKNI----KKNKGVKDWPWWKLF 1240
Query: 428 TTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKT 487
TT + +V+ E+Q++N EE ++SKL K E+ E ++ S+ + L ++
Sbjct: 1241 TTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISEL--TSEL 1298
Query: 488 LEEKNIQLSLEKQQMMEALDQLKS----KEHKTQSDMAIVNNENNRMSIEMEAMKTNILL 543
+E+N S + E ++L++ KE +TQ D + +EME M+ ++
Sbjct: 1299 TDERNTGESASQLLDAETAERLRAEKEMKELQTQYDAL----KKQMEVMEMEVMEARLIR 1354
Query: 544 --------------------------------------IQDEKEMLEKKTHQLLKEKSSL 565
+D+ E+ ++ QL + L
Sbjct: 1355 AAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDL 1414
Query: 566 GNELKESQLEIIQLKEK-ERLAKTEQETLLQII-ETVKDEKLNLETTLQESTAARQIMER 623
+ +ESQ + QLK+K +RL Q+T L + + V++ +L + +S ++ E
Sbjct: 1415 QADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEA 1474
Query: 624 EIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKE 683
+ E +Q + E++ L +EA K L E + ++ V+ L+
Sbjct: 1475 QREKLQREKLQREKDML------LAEAFSLKQQLEEKDMDIAGFTQKVVS-------LEA 1521
Query: 684 ELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICN 743
EL+ S + K E S++++ + LE V+ E E D ++ L++ L L ++
Sbjct: 1522 ELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMER 1581
Query: 744 QHNDPSK 750
SK
Sbjct: 1582 MRQTHSK 1588
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 76.3 bits (186), Expect = 1e-13
Identities = 87/424 (20%), Positives = 187/424 (44%), Gaps = 52/424 (12%)
Query: 354 EMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELES 413
E KD + F K S+ +E + S S E +AK++ L+ V+ Q++ ++ ++
Sbjct: 1503 EEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQA 1562
Query: 414 ENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEE----KSTIQSKLSKTEEYSKECLK 469
+ + + K + + + +T+ K++++ EE + + Q KL + E +E +
Sbjct: 1563 GTIQMLEQAK--LRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYE 1620
Query: 470 EFKKIISKYNVLQGQNKTLE----------EKNIQLSLEKQQMMEA-------------- 505
+ +K++ + L+G+ TL EK ++ L++ + + A
Sbjct: 1621 DKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAP 1680
Query: 506 ----LDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKE 561
+ QLK++ +++ A M +E+E + I I K LE++ +L +E
Sbjct: 1681 SKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQRE 1740
Query: 562 KSSLGNELKESQLEIIQLKEKERLAKTE-QETLLQI------IETVKDEKLNLETTLQ-- 612
K+ + N L+E Q ++ +L +K + A + L QI +E EK L+ LQ
Sbjct: 1741 KNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQAL 1800
Query: 613 --------ESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKEC 664
+S + ++ R+ I+ ++ E Q +K +S AS K ++ ++ +E
Sbjct: 1801 QSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQ-VKRLESLASRLKENMEKLTEER 1859
Query: 665 EMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLE 724
+ K N+ L+ +L+ +E + + + K LE + S+E +L+
Sbjct: 1860 DQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQ 1919
Query: 725 FEMR 728
+++
Sbjct: 1920 ADLK 1923
Score = 55.1 bits (131), Expect = 3e-07
Identities = 90/427 (21%), Positives = 178/427 (41%), Gaps = 73/427 (17%)
Query: 374 NEKTSKVNSVTEQCVAKIQYLQNYLKESVQ------IQKKVMELESENLNLKSKMKPLIF 427
+E+TS+ ++ + Q++ K +Q +QK + +N +K +F
Sbjct: 1185 DEQTSRNLTLFQAACRGYLARQHFKKRKIQDLAIRCVQKNI----KKNKGVKDWPWWKLF 1240
Query: 428 TTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKT 487
TT + +V+ E+Q++N EE ++SKL K E+ E ++ S+ + L ++
Sbjct: 1241 TTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISEL--TSEL 1298
Query: 488 LEEKNIQLSLEKQQMMEALDQLKS----KEHKTQSDMAIVNNENNRMSIEMEAMKTNILL 543
+E+N S + E ++L++ KE +TQ D + +EME M+ ++
Sbjct: 1299 TDERNTGESASQLLDAETAERLRAEKEMKELQTQYDAL----KKQMEVMEMEVMEARLIR 1354
Query: 544 --------------------------------------IQDEKEMLEKKTHQLLKEKSSL 565
+D+ E+ ++ QL + L
Sbjct: 1355 AAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDL 1414
Query: 566 GNELKESQLEIIQLKEK-ERLAKTEQETLLQII-ETVKDEKLNLETTLQESTAARQIMER 623
+ +ESQ + QLK+K +RL Q+T L + + V++ +L + +S ++ E
Sbjct: 1415 QADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEA 1474
Query: 624 EIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKE 683
+ E +Q + E++ L +EA K L E + ++ V+ L+
Sbjct: 1475 QREKLQREKLQREKDML------LAEAFSLKQQLEEKDMDIAGFTQKVVS-------LEA 1521
Query: 684 ELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICN 743
EL+ S + K E S++++ + LE V+ E E D ++ L++ L L ++
Sbjct: 1522 ELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMER 1581
Query: 744 QHNDPSK 750
SK
Sbjct: 1582 MRQTHSK 1588
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 76.3 bits (186), Expect = 1e-13
Identities = 146/743 (19%), Positives = 297/743 (39%), Gaps = 126/743 (16%)
Query: 47 ENQIQPQSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVE 106
E +I S++ +LE + + ++++ + E + + FE +K +H +
Sbjct: 707 EEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLA----FEKAKKIHLEQ 762
Query: 107 EKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIII--HPSENSDIL------- 157
K + L + Q E T+ L +II H E+ D L
Sbjct: 763 HKEMEKQIERLEAQLEKKDQQFKEQEKTMSM----LQQDIICKQHHLESLDRLLTESKGE 818
Query: 158 -KNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQ 216
K N A N +S+ +T+ + + + K +L+ + + ++ +++L+
Sbjct: 819 MKKENMKKDEALKALQNQVSE-ETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLK 877
Query: 217 KSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRIS 276
K + L EL+ + Q + +++E + ED ++K
Sbjct: 878 KKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEK 937
Query: 277 ELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKF 336
++ L ++L RE+ ++ RK ++ +S H + K K I +TG
Sbjct: 938 QVSKLEQELQKQRESSAEK----LRKMEEKCESAAHEA--DLKRQKVIELTG-------- 983
Query: 337 HSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKT--SKVNSVTEQCVAKIQYL 394
R +DQ K E+ E++ +K+ EN+ S+++ + +Q +++
Sbjct: 984 ---TARQVKIEMDQYKEELSKMEKEIMHLKRDG---ENKAMHLSQLDMILDQTKTELEKK 1037
Query: 395 QNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQ 454
N +KE ++Q E+E T++L QK E E +L+N E ++
Sbjct: 1038 TNAVKELEKLQHST---ETE-------------LTEAL-QKREVLETELQNAHGE---LK 1077
Query: 455 SKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKS--- 511
S L + +E K + KY ++ L E +++ +KQ+++E LK
Sbjct: 1078 STLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNW 1137
Query: 512 ----------------KEHKTQSDMAIVNNENNRMSIEMEAMKTNILL------IQDEKE 549
+EH+ + + I+ E E+E + N + +Q+ KE
Sbjct: 1138 ELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKE 1197
Query: 550 MLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQE----------TLLQIIET 599
L +K +L+ + + KE + ++KE E + K +++ L Q +
Sbjct: 1198 QLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRL 1257
Query: 600 VKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLS- 658
+++ N T L E+ + +REIE + + L+++K E + N L+
Sbjct: 1258 TREQVQNSHTELAEARHQQVQAQREIERLSSE--------LEDMKQLSKEKDAHGNHLAE 1309
Query: 659 EIG----KECEMLSKMVMETK---TDNQILKE----ELKKHSQENIKF-------ENSIS 700
E+G +E + ++M E K + + LKE E+ H + + K+ ++S+
Sbjct: 1310 ELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQ 1369
Query: 701 RLTEDKILLENYVRSIENERDTL 723
+L E LE +E +DT+
Sbjct: 1370 QLNEQ---LEKAKLELEEAQDTV 1389
Score = 67.4 bits (163), Expect = 5e-11
Identities = 84/408 (20%), Positives = 173/408 (42%), Gaps = 61/408 (14%)
Query: 375 EKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQ 434
E +K+ + + K Q LQ +E ++++ ++E + + + ++ + L +
Sbjct: 309 EAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSK 368
Query: 435 KVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQ 494
+ Y+K++ +E+ +Q++ E C KE NK L+E+
Sbjct: 369 AFQQYKKKVAEKLEK---VQAEEEILERNLTNCEKE--------------NKRLQERCGL 411
Query: 495 LSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKK 554
E + + E L QLK + + + + I+ +N+ + ++ + +IL ++ E LE K
Sbjct: 412 YKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESE---LENK 468
Query: 555 THQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQES 614
++L++K SL NE +E L++ + ERL +QE IE+ + E +LE + +
Sbjct: 469 -DEILRDKFSLMNENRE--LKVRVAAQNERLDLCQQE-----IESSRVELRSLEKIISQL 520
Query: 615 TAARQIMEREIENIQTYQSTAEEN-----------------------FLQEIKNAKSEAS 651
R++ + + YQ ++ N ++E + K A+
Sbjct: 521 PLKRELFGFK-SYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHAN 579
Query: 652 IYKNSLSEI------GKECEMLSKMVME-TKTDNQILKEELKKHSQE--NIKFENSISRL 702
+ N LS+ +E LS + E K + E +K +Q N ++E RL
Sbjct: 580 LTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRL 639
Query: 703 TEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSK 750
L + IE E L+ M H ++ + +++ + ++ SK
Sbjct: 640 VTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSK 687
Score = 62.8 bits (151), Expect = 1e-09
Identities = 96/461 (20%), Positives = 197/461 (42%), Gaps = 47/461 (10%)
Query: 346 SFLDQTKHEMK---DKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESV 402
S DQ +H M +KERQ + E +T + E K+ + + +
Sbjct: 619 SVKDQNQHTMNKQYEKERQRLVTG-----IEELRTKLIQIEAENSDLKVN-MAHRTSQFQ 672
Query: 403 QIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEE 462
IQ++++E S + L+S+M T+ Q + T EKQL+ + S+I +K ++ E+
Sbjct: 673 LIQEELLEKASNSSKLESEM------TKKCSQLL-TLEKQLEEKIVAYSSIAAKNAELEQ 725
Query: 463 YSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEAL-----DQLKSKEHKTQ 517
E ++ + + + N + EK ++ LE+ + ME QL+ K+ + +
Sbjct: 726 ELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFK 785
Query: 518 SDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEII 577
++ + + +++ L+ + K ++K+ + + +L N++ E +++
Sbjct: 786 EQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVR 845
Query: 578 QLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIE-NIQTYQSTAE 636
QL + K E L+ + ++ K E L++ + +++E++ + Q T+E
Sbjct: 846 QLDSALEICKEE---LVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSE 902
Query: 637 ENF-----LQEIKNAKSEASIYKNSLSEIGKECE-MLSKMVMETKTDNQILKEELKKHSQ 690
+N LQ+ + + +I L + + E +SK+ E + + E+L+K +
Sbjct: 903 QNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEE 962
Query: 691 ENIKFENSISRLTEDKILLENYVRSIENERD-------TLEFEMRHLQRE------YLSL 737
+ + + I L R ++ E D +E E+ HL+R+ +LS
Sbjct: 963 KCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQ 1022
Query: 738 SDKICNQHND--PSKTTYISRREKFHFDNYTHEDTSSPQSR 776
D I +Q KT + EK T E T + Q R
Sbjct: 1023 LDMILDQTKTELEKKTNAVKELEKLQHSTET-ELTEALQKR 1062
Score = 61.6 bits (148), Expect = 3e-09
Identities = 111/536 (20%), Positives = 222/536 (41%), Gaps = 92/536 (17%)
Query: 273 KRISELEALVKKLLPFRETVSKFHVHF----------CRKCKKLSKSEMHRGKKNEKNNK 322
K IS+L L ++L F+ +SK+ + C + KL SE+
Sbjct: 515 KIISQLP-LKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELR---------- 563
Query: 323 EIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQ-----GSIISENEKT 377
I + K K H+ + LS T ++ ++ + L + G ++E+ K
Sbjct: 564 -IKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKD 622
Query: 378 SKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVE 437
+++ +Q + Q L ++E ++ K++++E+EN +LK M T+Q + + E
Sbjct: 623 QNQHTMNKQYEKERQRLVTGIEE---LRTKLIQIEAENSDLKVNMAHR--TSQFQLIQEE 677
Query: 438 TYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSL 497
EK S ++S+++K K + L K LEEK + S
Sbjct: 678 LLEK-----ASNSSKLESEMTK-----------------KCSQLLTLEKQLEEKIVAYSS 715
Query: 498 EKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEM------- 550
+ E +L K K +S +N E+ ++ + E K + ++ KEM
Sbjct: 716 IAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFE--KAKKIHLEQHKEMEKQIERL 773
Query: 551 ---LEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLN- 606
LEKK Q +++ ++ ++ + L+ +RL TE + ++ KDE L
Sbjct: 774 EAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLL-TESKGEMKKENMKKDEALKA 832
Query: 607 LETTLQEST-------AARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSE 659
L+ + E T +A +I + E+ +E F +++K E
Sbjct: 833 LQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYC------- 885
Query: 660 IGKECEMLSKMVMETKTDNQILKEELKKHSQ-------ENIKFENSISRLTEDKILLENY 712
+ KE ++ + + ET N IL+ L++ Q N + E++ ++L + LE
Sbjct: 886 LQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLE-- 943
Query: 713 VRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRREKFHFDNYTHE 768
+ ++ +R++ ++R ++ + S + + + + T +R+ K D Y E
Sbjct: 944 -QELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEE 998
Score = 44.7 bits (104), Expect = 3e-04
Identities = 81/424 (19%), Positives = 172/424 (40%), Gaps = 86/424 (20%)
Query: 413 SENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFK 472
S+ N ++ + L+ SL +++ E L++L EE S++ S+ +Y+ + K
Sbjct: 124 SDYYNKDNEEESLLANVASLRHELKITEWSLQSLGEELSSVSP--SENSDYAPNPSRSEK 181
Query: 473 KIISKYNVLQGQ-NKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMS 531
I+ G N + E ++S + D K K S A V+ E
Sbjct: 182 LILDVQPSHPGLLNYSPYENVCKIS------GSSTDFQKKPRDKMFSSSAPVDQE----- 230
Query: 532 IEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLA----- 586
+++++ + ++ + L + H L+ + S+ EL +S+ ++ L+ ++ A
Sbjct: 231 --IKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPI 288
Query: 587 ------------------------KTEQETLL-----QIIETVKDEKLNLETTLQESTAA 617
K EQ + Q ++ K+E + L+ L E T
Sbjct: 289 LEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQ 348
Query: 618 RQIMERE-------IENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKM 670
+ ER+ E + ++ ++++ ++E I + +L+ KE + L +
Sbjct: 349 GKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQER 408
Query: 671 VMETKTDNQILKEELKKHSQEN-----------IKFENSISRLTEDKILLENYVRSIEN- 718
K++ +ILKE+L++ +EN +K +++LTE + + +EN
Sbjct: 409 CGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENK 468
Query: 719 -----ERDTLEFEMRHLQREYLSLSDK--ICNQHNDPSKTTYIS----------RREKFH 761
++ +L E R L+ + +++ +C Q + S+ S +RE F
Sbjct: 469 DEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFG 528
Query: 762 FDNY 765
F +Y
Sbjct: 529 FKSY 532
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.125 0.330
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,923,609
Number of Sequences: 37866
Number of extensions: 1196386
Number of successful extensions: 11944
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 325
Number of HSP's successfully gapped in prelim test: 1017
Number of HSP's that attempted gapping in prelim test: 5653
Number of HSP's gapped (non-prelim): 3875
length of query: 796
length of database: 18,247,518
effective HSP length: 110
effective length of query: 686
effective length of database: 14,082,258
effective search space: 9660428988
effective search space used: 9660428988
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.