Guide to the Human Genome
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Search of human proteins with 224586823

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|224586823 coiled-coil domain containing 110 isoform b [Homo
sapiens]
         (796 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|224586823 coiled-coil domain containing 110 isoform b [Homo s...  1557   0.0  
gi|22749515 coiled-coil domain containing 110 isoform a [Homo sa...  1539   0.0  
gi|55770834 centromere protein F [Homo sapiens]                       108   2e-23
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...    95   2e-19
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...    95   3e-19
gi|71061468 centromere protein E [Homo sapiens]                        94   5e-19
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             93   8e-19
gi|41872583 Rho-associated, coiled-coil containing protein kinas...    92   2e-18
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...    89   2e-17
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     88   4e-17
gi|38044112 restin isoform b [Homo sapiens]                            83   9e-16
gi|4506751 restin isoform a [Homo sapiens]                             83   9e-16
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     82   1e-15
gi|58530840 desmoplakin isoform I [Homo sapiens]                       82   2e-15
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]    81   3e-15
gi|217272802 hyaluronan-mediated motility receptor isoform a [Ho...    81   3e-15
gi|217272804 hyaluronan-mediated motility receptor isoform d [Ho...    81   4e-15
gi|109255234 centrosomal protein 290kDa [Homo sapiens]                 80   6e-15
gi|31982906 cingulin-like 1 [Homo sapiens]                             80   6e-15
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]                    80   6e-15
gi|87298937 centrosomal protein 110kDa [Homo sapiens]                  80   1e-14
gi|4885583 Rho-associated, coiled-coil containing protein kinase...    79   1e-14
gi|109134347 NY-REN-58 antigen [Homo sapiens]                          77   5e-14
gi|109134355 NY-REN-58 antigen [Homo sapiens]                          77   5e-14
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]         77   6e-14
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]    76   1e-13
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]         76   1e-13
gi|42794779 myosin 18A isoform b [Homo sapiens]                        76   1e-13
gi|28416946 myosin 18A isoform a [Homo sapiens]                        76   1e-13
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]                   76   1e-13

>gi|224586823 coiled-coil domain containing 110 isoform b [Homo
           sapiens]
          Length = 796

 Score = 1557 bits (4032), Expect = 0.0
 Identities = 796/796 (100%), Positives = 796/796 (100%)

Query: 1   MSPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQ 60
           MSPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQ
Sbjct: 1   MSPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQ 60

Query: 61  QQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQS 120
           QQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQS
Sbjct: 61  QQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQS 120

Query: 121 VNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADT 180
           VNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADT
Sbjct: 121 VNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADT 180

Query: 181 VILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHR 240
           VILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHR
Sbjct: 181 VILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHR 240

Query: 241 NGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFC 300
           NGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFC
Sbjct: 241 NGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFC 300

Query: 301 RKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKER 360
           RKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKER
Sbjct: 301 RKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKER 360

Query: 361 QPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKS 420
           QPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKS
Sbjct: 361 QPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKS 420

Query: 421 KMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNV 480
           KMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNV
Sbjct: 421 KMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNV 480

Query: 481 LQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTN 540
           LQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTN
Sbjct: 481 LQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTN 540

Query: 541 ILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETV 600
           ILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETV
Sbjct: 541 ILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETV 600

Query: 601 KDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEI 660
           KDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEI
Sbjct: 601 KDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEI 660

Query: 661 GKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENER 720
           GKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENER
Sbjct: 661 GKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENER 720

Query: 721 DTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRREKFHFDNYTHEDTSSPQSRPLAS 780
           DTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRREKFHFDNYTHEDTSSPQSRPLAS
Sbjct: 721 DTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRREKFHFDNYTHEDTSSPQSRPLAS 780

Query: 781 DLKGYFKVKDRTLKHH 796
           DLKGYFKVKDRTLKHH
Sbjct: 781 DLKGYFKVKDRTLKHH 796


>gi|22749515 coiled-coil domain containing 110 isoform a [Homo
           sapiens]
          Length = 833

 Score = 1539 bits (3984), Expect = 0.0
 Identities = 796/833 (95%), Positives = 796/833 (95%), Gaps = 37/833 (4%)

Query: 1   MSPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQ 60
           MSPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQ
Sbjct: 1   MSPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQ 60

Query: 61  QQLESFQALRMQTLQNVSM-------------------------------------PTEN 83
           QQLESFQALRMQTLQNVSM                                     PTEN
Sbjct: 61  QQLESFQALRMQTLQNVSMVQSEISEILNKSIIEVENPQFSSEKNLVFGTRIEKDLPTEN 120

Query: 84  QEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLS 143
           QEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLS
Sbjct: 121 QEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLS 180

Query: 144 SNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDD 203
           SNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDD
Sbjct: 181 SNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDD 240

Query: 204 ICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLD 263
           ICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLD
Sbjct: 241 ICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLD 300

Query: 264 GNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKE 323
           GNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKE
Sbjct: 301 GNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKE 360

Query: 324 IPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSV 383
           IPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSV
Sbjct: 361 IPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSV 420

Query: 384 TEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQL 443
           TEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQL
Sbjct: 421 TEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQL 480

Query: 444 KNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMM 503
           KNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMM
Sbjct: 481 KNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMM 540

Query: 504 EALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKS 563
           EALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKS
Sbjct: 541 EALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKS 600

Query: 564 SLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMER 623
           SLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMER
Sbjct: 601 SLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMER 660

Query: 624 EIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKE 683
           EIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKE
Sbjct: 661 EIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKE 720

Query: 684 ELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICN 743
           ELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICN
Sbjct: 721 ELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICN 780

Query: 744 QHNDPSKTTYISRREKFHFDNYTHEDTSSPQSRPLASDLKGYFKVKDRTLKHH 796
           QHNDPSKTTYISRREKFHFDNYTHEDTSSPQSRPLASDLKGYFKVKDRTLKHH
Sbjct: 781 QHNDPSKTTYISRREKFHFDNYTHEDTSSPQSRPLASDLKGYFKVKDRTLKHH 833


>gi|55770834 centromere protein F [Homo sapiens]
          Length = 3114

 Score =  108 bits (270), Expect = 2e-23
 Identities = 159/730 (21%), Positives = 322/730 (44%), Gaps = 100/730 (13%)

Query: 60   QQQLESFQALRMQTLQNVSMP--TENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSL 117
            ++QL   + L+ +  +N S+    EN E  L M + +  ++   L +   K   +++ + 
Sbjct: 2133 KKQLHIAEKLKERERENDSLKDKVENLERELQMSEEN--QELVILDAENSKAEVETLKTQ 2190

Query: 118  PQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQ 177
             + +    ++   D +TLR+  +NL+  I     + S++ K  ++F   L         Q
Sbjct: 2191 IEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEK-----EQ 2245

Query: 178  ADTVILDKSKITVPFLKHGFCENLDDIC------HSIKQMKEELQKSHDGEVALTNELQT 231
            A+  I ++SK  V  L++   E  + +         +K  ++ L    + E  L N ++ 
Sbjct: 2246 AEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEK 2305

Query: 232  LQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDG---NLNEDIKSKRISELEALVKKLLPF 288
            L+    +  + K  +  + Q K +    + L G   NL  +++  R ++  A ++     
Sbjct: 2306 LRAR--LEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEA---- 2359

Query: 289  RETVSKFHVHFCRKCKKLSKSEMHRGK-------KNEKNN--KEIPITGKNITDLKFHSR 339
                SK  V    K K    ++  RG        ++EK N   E+    + I++L+  + 
Sbjct: 2360 --ENSKGEVETL-KAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINS 2416

Query: 340  VPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLK 399
                 L   +Q K +MK+K      + Q  +   NE+ + +++  E C AK Q L + ++
Sbjct: 2417 SFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVE 2476

Query: 400  ----ESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQS 455
                E  Q+ + + E ++  + L+S +         LIQ+VE  +++L+   EE S +++
Sbjct: 2477 CLELEKAQLLQGLDEAKNNYIVLQSSVN-------GLIQEVEDGKQKLEKKDEEISRLKN 2529

Query: 456  KLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHK 515
            ++   E+           ++SK + ++G+++  +E+N++L     ++ + +  L+SK   
Sbjct: 2530 QIQDQEQ-----------LVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNAS 2578

Query: 516  TQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLE 575
             Q  + ++ +    +  E+E  K + +   ++   +  K  +L +E   +  +  E Q E
Sbjct: 2579 LQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEE 2638

Query: 576  IIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQI-------MERE---I 625
            +    EK RLA  E + LL+ I++ KD+    E TL+ S   + +       +E+E    
Sbjct: 2639 L--SGEKNRLA-GELQLLLEEIKSSKDQL--KELTLENSELKKSLDCMHKDQVEKEGKVR 2693

Query: 626  ENIQTYQSTAEEN-------FLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVME----- 673
            E I  YQ    E         L   K  + E   Y+  L+   +EC    K+ ++     
Sbjct: 2694 EEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTS-KEECLSSQKLEIDLLKSS 2752

Query: 674  -------TKTDNQILKEELKKHSQENIKFENSISRLTED-----KILLENYVRSIENERD 721
                    K   QIL EELKK   +N+K+ N + +  E      K+L+++  + +E E++
Sbjct: 2753 KEELNNSLKATTQIL-EELKKTKMDNLKYVNQLKKENERAQGKMKLLIKS-CKQLEEEKE 2810

Query: 722  TLEFEMRHLQ 731
             L+ E+  LQ
Sbjct: 2811 ILQKELSQLQ 2820



 Score = 80.1 bits (196), Expect = 7e-15
 Identities = 146/706 (20%), Positives = 299/706 (42%), Gaps = 108/706 (15%)

Query: 44   AESEN---QIQP-QSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDS 99
            +E EN   QIQ  Q  L  L + L SF++L  +  Q      E  +  + M ++      
Sbjct: 2210 SEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQ----L 2265

Query: 100  KTLHSVEEKLSGDS--VNSLPQSVNVPSQI-----HSEDTLTLRTSTDNLSSNIIIHPSE 152
            K L+     L GD   + +  QS++ P +      +S + L  R   D      ++   +
Sbjct: 2266 KELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLK 2325

Query: 153  NS----DILKN-YNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHS 207
             S    D+LK    N  R L  A  N    A  +  + SK  V  LK      ++ +  S
Sbjct: 2326 ESEHHADLLKGRVENLERELEIARTNQEHAA--LEAENSKGEVETLK----AKIEGMTQS 2379

Query: 208  IKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLN 267
            ++ ++ ++      +  LTNELQ  Q           ++  I+    N ++E+  +    
Sbjct: 2380 LRGLELDVVTIRSEKENLTNELQKEQERIS-------ELEIINSSFENILQEKEQE---K 2429

Query: 268  EDIKSKRISELEALVKKLLPFRETVSKFH--VHFCR----------KCKKLSKSEMHRGK 315
              +K K  + +E L  +L    E V+  H     C+          +C +L K+++ +G 
Sbjct: 2430 VQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGL 2489

Query: 316  KNEKNNKEIPITGKN--ITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQ--GSII 371
               KNN  +  +  N  I +++   +        + + K++++D+E+    + Q  G   
Sbjct: 2490 DEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQ 2549

Query: 372  SENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQS 431
               E+  ++ ++T +   KIQ LQ+   ++  +Q  +  L+S   NL+++++       S
Sbjct: 2550 LWKEQNLELRNLTVELEQKIQVLQS---KNASLQDTLEVLQSSYKNLENELELTKMDKMS 2606

Query: 432  LIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEK 491
             ++KV    K      E +  +     KT E  +E   E  ++  +  +L  + K+ +++
Sbjct: 2607 FVEKVN---KMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQ 2663

Query: 492  NIQLSLEKQQMMEALDQLKS----KEHKTQSDMA---------------IVNNENNRMSI 532
              +L+LE  ++ ++LD +      KE K + ++A               ++ + N +  +
Sbjct: 2664 LKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEV 2723

Query: 533  EME--------------AMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLE--- 575
            E++              + K  I L++  KE L       LK  + +  ELK+++++   
Sbjct: 2724 EIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNS----LKATTQILEELKKTKMDNLK 2779

Query: 576  -IIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQ------IMEREIENI 628
             + QLK++   A+ + + L++  + +++EK  L+  L +  AA++      +M+ +++ +
Sbjct: 2780 YVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDEL 2839

Query: 629  QTYQSTAEENFLQEIKNAKSEASIYKNSL---SEIGKECEMLSKMV 671
             T     +E   ++ K A      Y + L    ++ K  EML   V
Sbjct: 2840 TTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQV 2885



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 135/607 (22%), Positives = 250/607 (41%), Gaps = 107/607 (17%)

Query: 202  DDICHSIKQMKEE--LQKSHDGEVA-----LTNELQTLQTDPDVHRNGKYDMSPIHQDKM 254
            +++  S+++MK+E  L KSH  + A     L  EL+ ++   +  +N   +M   +  + 
Sbjct: 475  NELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQE 534

Query: 255  NFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRG 314
              +++  L   +N+   S  + +L+  V  L   R+               L K E H  
Sbjct: 535  TMLRD--LQEKINQQENSLTLEKLKLAVADLEKQRDCSQDL----------LKKREHHIE 582

Query: 315  KKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISEN 374
            + N+K +K                +  +  LS L+  K E ++ + +  L       SEN
Sbjct: 583  QLNDKLSKT--------------EKESKALLSALELKKKEYEELKEEKTLFSCWK--SEN 626

Query: 375  EKT-SKVNSVTEQCVAKIQYLQNYLK----ESVQIQKKVMELESENLNLKSKMKPLIFTT 429
            EK  +++ S  E   +KI +L+  LK    +S +  ++V  LE +  NL  +++ L    
Sbjct: 627  EKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVL 686

Query: 430  QSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLE 489
             S   +VET          +K        K E   ++  KE + +  K + L GQ + LE
Sbjct: 687  DSKSVEVET----------QKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLE 736

Query: 490  EKNIQLS---LEKQQMMEAL--------DQLKSKEHKTQSDMAIVNNENNRMSIEMEAMK 538
             K   LS   ++K +  + L        D LKSK      D ++V NE+++ S       
Sbjct: 737  HKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSK------DASLVTNEDHQRS------- 783

Query: 539  TNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIE 598
               LL  D++  +      ++ E+ S+ +E  E +LE  Q  +   + +   ++L   +E
Sbjct: 784  ---LLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLE 840

Query: 599  TVKDEKLNLETTLQESTAAR-QIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSL 657
            + K    +L+   +E    + +I E  ++  Q +QS   E   Q I   + + S ++N +
Sbjct: 841  SQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETS-QRISKLQEDTSAHQNVV 899

Query: 658  SEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIE 717
            +E     E   K +       Q+L ++++    E       I  L +   LLE+ ++ ++
Sbjct: 900  AETLSALENKEKEL-------QLLNDKVETEQAE-------IQELKKSNHLLEDSLKELQ 945

Query: 718  NERDTLEFEMRHL-------QREYLSLSD-----KICNQHNDPSKTTYISRREKFHFDNY 765
               +TL  E + +       +RE   L+      K  N   +  K   I + E   F NY
Sbjct: 946  LLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSES--FANY 1003

Query: 766  THEDTSS 772
              E   S
Sbjct: 1004 IDEREKS 1010



 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 93/455 (20%), Positives = 192/455 (42%), Gaps = 53/455 (11%)

Query: 348 LDQTK---HEMKDKERQPFLVKQGSIISENEKTSKVNSVTE----------QCVAKIQYL 394
           LDQ K    E+++K  +  L  QG    E E   +VN   E          + + K + L
Sbjct: 280 LDQLKAQNQELRNKINELELRLQGH---EKEMKGQVNKFQELQLQLEKAKVELIEKEKVL 336

Query: 395 QNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKST-I 453
                E V+   +  +  ++   L+ K+K L        Q  E+    L+  ++EK    
Sbjct: 337 NKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEF 396

Query: 454 QSKLSKTEE----YSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQL 509
           Q +LS+ +       +EC++   ++  +    +  +  L+ +  +L+  KQQ+   L++ 
Sbjct: 397 QEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEF 456

Query: 510 KSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNEL 569
           K K  + +        + N +   ME MK    L++   E   ++   L  E  ++   L
Sbjct: 457 KQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCL 516

Query: 570 KESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQ 629
            +SQ       E+ +   T QET+L+ ++    EK+N     QE++   + ++  + +++
Sbjct: 517 NQSQ----NFAEEMKAKNTSQETMLRDLQ----EKIN----QQENSLTLEKLKLAVADLE 564

Query: 630 TYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHS 689
             +  +++     +K  +       + LS+  KE + L   +   K + + LKEE    S
Sbjct: 565 KQRDCSQD----LLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFS 620

Query: 690 QENIKFENSISRLTEDKILLENYVRSIENERDTLEFE-------MRHLQREYLSLSDKIC 742
               + E  ++++  +K  L++ +  +E    T + +       +R L+ +  +LS +I 
Sbjct: 621 CWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIR 680

Query: 743 NQHN---------DPSKTTYISRREKFHFDNYTHE 768
           N HN         +  K  Y+  ++K  F +  H+
Sbjct: 681 NLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQ 715



 Score = 73.6 bits (179), Expect = 7e-13
 Identities = 92/411 (22%), Positives = 183/411 (44%), Gaps = 53/411 (12%)

Query: 353  HEMKDKERQPFLVKQGSIISE-NEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMEL 411
            H ++D++R     K  S+++E  E  SK++    Q + KI+         ++++K V EL
Sbjct: 1788 HVIEDRDR-----KVESLLNEMKELDSKLHLQEVQLMTKIE-------ACIELEKIVGEL 1835

Query: 412  ESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNL-----VEEKSTIQSKLSKTEEYSKE 466
            + EN +L  K++      Q L+Q+VET E    +L        +  I   ++K  +  KE
Sbjct: 1836 KKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKE 1895

Query: 467  CLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMM-EALDQLKSKEHK------TQSD 519
                F  + ++ + ++ +  ++E + + L  + + +  E L   K  E+K       + +
Sbjct: 1896 ---RFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEE 1952

Query: 520  MAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQL 579
            +++V +E N++  E++ M      +    E +++KT +L   +S          L  IQ+
Sbjct: 1953 LSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSEC--------LHCIQV 2004

Query: 580  KEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENF 639
             E E   KTE   LLQ + +   E L  +T LQE     Q +E++ + +   +   E   
Sbjct: 2005 AEAEVKEKTE---LLQTLSSDVSELLKDKTHLQEKL---QSLEKDSQALSLTKCELENQI 2058

Query: 640  LQEIKNAK---SEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFE 696
             Q  K  +    E+   +  LSE   E   +SK +     +       L    +E  +  
Sbjct: 2059 AQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLR 2118

Query: 697  NSISRL-------TEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDK 740
              I +L        + ++ +   ++  E E D+L+ ++ +L+RE L +S++
Sbjct: 2119 RGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERE-LQMSEE 2168



 Score = 73.2 bits (178), Expect = 9e-13
 Identities = 161/788 (20%), Positives = 320/788 (40%), Gaps = 156/788 (19%)

Query: 51   QPQSALKVLQQQL----ESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVE 106
            Q ++ L+  +Q+L    ++FQA +++  +      E ++EN ++ KSH  + ++ +  +E
Sbjct: 448  QLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKEN-NLLKSHSEQKAREVCHLE 506

Query: 107  EKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRF 166
             +L      ++ Q +N  SQ  +E+     TS + +  ++                    
Sbjct: 507  AELK-----NIKQCLN-QSQNFAEEMKAKNTSQETMLRDL-------------------- 540

Query: 167  LPTAPPNVMSQADTVILDKSKITVPFL-KHGFCEN--LDDICHSIKQMKEELQKSHDGEV 223
                   +  Q +++ L+K K+ V  L K   C    L    H I+Q+ ++L K+     
Sbjct: 541  ----QEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESK 596

Query: 224  ALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFI-----KEENLDGNLNE---DIKSKRI 275
            AL + L+  + + +  +  K   S    +    +     ++ENL   +N     +K+++I
Sbjct: 597  ALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQI 656

Query: 276  S--ELEALVKKLLPFRETVS----KFHVHFCRKC-----KKLSKSEMHRGKK--NEKNNK 322
               E    V+ L   RE +S      H     K      +KL+  E+ +  +  ++K+ K
Sbjct: 657  KSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQK 716

Query: 323  EIP--------ITGKNITDLKFHSRVPRYTLSFLD---QTKHEMKDKERQPFLVKQGSII 371
            EI         +TG+ + DL+   ++    +   D   Q  H   +  R     K  S++
Sbjct: 717  EIENMCLKTSQLTGQ-VEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLV 775

Query: 372  SENEKTSKVNSVTEQCVAKIQYLQNYLKE--SVQIQKKVMELESE-----NLNLKSKMKP 424
            + NE   +     +Q  A      N + E  S+  ++    LE++     +  L++++  
Sbjct: 776  T-NEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDS 834

Query: 425  LIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISK------- 477
            L F+ +S  Q     +KQ + LV+ K  I+  L K E+  +  + E  + ISK       
Sbjct: 835  LEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSA 894

Query: 478  -YNVLQGQNKTLE--EKNIQLSLEKQQMMEA-LDQLKSKEHKTQSDMAIVNNENNRMSIE 533
              NV+      LE  EK +QL  +K +  +A + +LK   H  +  +  +   +  +S+E
Sbjct: 895  HQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLE 954

Query: 534  MEAMKTNILLIQDEKE--------------MLEKKTHQLLKEKSSLGNELKESQLEIIQL 579
             + M + I L + E E               L ++   L+++  S  N + E +  I +L
Sbjct: 955  KKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISEL 1014

Query: 580  KEKERLAK-----------TEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENI 628
             ++ +  K              E L Q  +  +++   LE  L E T+  +  + E+E +
Sbjct: 1015 SDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQL 1074

Query: 629  QTYQSTAEENFLQEI-----------------------------KNAKSEASIYKNSLSE 659
            +   +   + FL ++                              N+KSEA   K  +  
Sbjct: 1075 KEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMT 1134

Query: 660  IGKECEMLSKMVMETKTDNQILKEELK-KHSQENIKFENSISRLTEDKILLENYVRSIEN 718
            + +E   + K V +   +N+ L + +K KH  +N++ E            + N V+  E+
Sbjct: 1135 LKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEP-----------IRNSVKERES 1183

Query: 719  ERDTLEFE 726
            ER+   F+
Sbjct: 1184 ERNQCNFK 1191



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 134/745 (17%), Positives = 291/745 (39%), Gaps = 81/745 (10%)

Query: 35   CSDTEYGCIAESENQI---------------QPQSALKVLQQQLESFQALRMQTLQNVSM 79
            C + E   +    NQ+               Q    +K   Q+LES Q+  +  +Q    
Sbjct: 1948 CLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEA 2007

Query: 80   PTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTST 139
              + + E L    S   E  K    ++EKL         QS+   SQ  S     L    
Sbjct: 2008 EVKEKTELLQTLSSDVSELLKDKTHLQEKL---------QSLEKDSQALSLTKCELENQI 2058

Query: 140  DNLSSN--IIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGF 197
              L+    +++  SE+     + +++ +       NV    +  +++K +  +       
Sbjct: 2059 AQLNKEKELLVKESESLQARLSESDYEKL------NVSKALEAALVEKGEFALRLSSTQ- 2111

Query: 198  CENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFI 257
             E +  +   I++++  ++     ++ +  +L+  + + D  ++                
Sbjct: 2112 -EEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKD---------------- 2154

Query: 258  KEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKN 317
            K ENL+  L    +++ +  L+A   K     ET+        R  K      +    + 
Sbjct: 2155 KVENLERELQMSEENQELVILDAENSKAEV--ETLKTQIEEMARSLKVFELDLVTLRSEK 2212

Query: 318  EKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKT 377
            E   K+I      +++L       +  L   +Q + ++K++ +    + Q  +   NE  
Sbjct: 2213 ENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAV 2272

Query: 378  SKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMEL-------ESENLNLKSKMKPLIFTTQ 430
            + +    E   A  Q L   ++E  Q++  + +L       E + L +  ++K       
Sbjct: 2273 AALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHAD 2332

Query: 431  SLIQKVETYEKQLK--NLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTL 488
             L  +VE  E++L+     +E + ++++ SK E    E LK   KI      L+G    L
Sbjct: 2333 LLKGRVENLERELEIARTNQEHAALEAENSKGEV---ETLKA--KIEGMTQSLRG----L 2383

Query: 489  EEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNIL-LIQDE 547
            E   + +  EK+ +   L     KE +  S++ I+N+    +  E E  K  +       
Sbjct: 2384 ELDVVTIRSEKENLTNELQ----KEQERISELEIINSSFENILQEKEQEKVQMKEKSSTA 2439

Query: 548  KEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNL 607
             EML+ +  +L +  ++L N+ +  + +   L  +    + E+  LLQ ++  K+  + L
Sbjct: 2440 MEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVL 2499

Query: 608  ETT----LQESTAARQIMEREIENIQTYQSTAE--ENFLQEIKNAKSEASIYKNSLSEIG 661
            +++    +QE    +Q +E++ E I   ++  +  E  + ++   + E  ++K    E+ 
Sbjct: 2500 QSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELR 2559

Query: 662  KECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERD 721
                 L + +   ++ N  L++ L+         EN +     DK+     V  +  +  
Sbjct: 2560 NLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKET 2619

Query: 722  TLEFEMRHLQREYLSLSDKICNQHN 746
             L+ EM  + ++   L +++  + N
Sbjct: 2620 ELQREMHEMAQKTAELQEELSGEKN 2644



 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 168/841 (19%), Positives = 324/841 (38%), Gaps = 138/841 (16%)

Query: 17   LLSASKILNSSEGVKESGC-SDTEYGCIAESENQIQPQSALKVLQQQLESFQALRMQTLQ 75
            LL+  KILN   G+       D   G   E  N+  P S   +   +  S++ L +   +
Sbjct: 1342 LLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPL--DESNSYEHLTLSDKE 1399

Query: 76   NVSMPTENQEENLSMEKSH------HFEDSKTLHSVEEKLSGDSVNSLPQSVNVPS---Q 126
                  E QE+ LS++  H      H + S  +  ++  +      +L  S N+ +    
Sbjct: 1400 VQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGD 1459

Query: 127  IHSEDTLTLRTS-TDNLSSNIIIHPSENSDILKNYNNFYRFL--PTAPPNVMSQADTVI- 182
            +  E  L L      +LSS+ +   S  S +    ++FYR L   T   +++S  +  + 
Sbjct: 1460 LVKEMQLGLEEGLVPSLSSSCVPDSSSLSSL--GDSSFYRALLEQTGDMSLLSNLEGAVS 1517

Query: 183  -------------LDKSKIT---VPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALT 226
                         L +  +T    P       E L+ +C   +Q  E+L++  + +  + 
Sbjct: 1518 ANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMK 1577

Query: 227  N-ELQTLQT-------DPDVHRNGKYDMSPIHQDKMNFI-----------KEENLDGNLN 267
            N E+Q L+        + D  R      +   Q K+  +           K++    +L 
Sbjct: 1578 NKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLE 1637

Query: 268  EDIKSKRISELEALVKKLLPF---------RETVSKFHVHFCRKCKKLSKSEMHRGKKNE 318
             ++   ++  L+   + LL            E+      H     ++  K ++H+    +
Sbjct: 1638 LEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKD 1697

Query: 319  KNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTS 378
               +++ +  + IT+          +      T +E   +++      QGS    +E  S
Sbjct: 1698 AQ-QDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKT-----QGS----SECIS 1747

Query: 379  KVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNL-------KSKMKPLIFTTQS 431
            +++      +  + +L N  ++   +Q +V E  +ENL L         K++ L+   + 
Sbjct: 1748 ELSFSGPNALVPMDFLGNQ-EDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKE 1806

Query: 432  LIQKVETYEKQLKNLVE---EKSTIQSKLSKTEEYSKECLKEF----KKIISKYNVLQGQ 484
            L  K+   E QL   +E   E   I  +L K      E L+ F    ++++ +    +G 
Sbjct: 1807 LDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGL 1866

Query: 485  NKTLEEKNIQLSLEK--QQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAM--KTN 540
            N  LE    + S E     + +  D  K +    +++++ + +E  + SIE EA+  + +
Sbjct: 1867 NSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSE--KASIEHEALYLEAD 1924

Query: 541  ILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETV 600
            + ++Q EK  LEK      K    L  EL     E  QL+ +      +   L Q+ E +
Sbjct: 1925 LEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKM 1984

Query: 601  KDEKLNLETTLQESTAARQIMEREI----ENIQTYQSTAEE---------NFLQEIKNAK 647
            K++   LE+   E     Q+ E E+    E +QT  S   E           LQ ++   
Sbjct: 1985 KEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDS 2044

Query: 648  SEASIYK----NSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSIS--- 700
               S+ K    N ++++ KE E+L K       +++ L+  L +   E +    ++    
Sbjct: 2045 QALSLTKCELENQIAQLNKEKELLVK-------ESESLQARLSESDYEKLNVSKALEAAL 2097

Query: 701  --------RLTEDKILLENYVRSIENERDTLEFE----------MRHLQREYLSLSDKIC 742
                    RL+  +  +    R IE  R  +E +          ++  +RE  SL DK+ 
Sbjct: 2098 VEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVE 2157

Query: 743  N 743
            N
Sbjct: 2158 N 2158



 Score = 37.7 bits (86), Expect = 0.042
 Identities = 144/793 (18%), Positives = 316/793 (39%), Gaps = 113/793 (14%)

Query: 59   LQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLP 118
            L+ Q +    L+ Q  + V +  E +E  +  E+ H    ++T   + +     S +   
Sbjct: 839  LESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNV 898

Query: 119  QSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQA 178
             +  + +  + E  L L      L+  +    +E  ++ K+ +     L  +   +   +
Sbjct: 899  VAETLSALENKEKELQL------LNDKVETEQAEIQELKKSNH----LLEDSLKELQLLS 948

Query: 179  DTVILDKSKIT-VPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPD 237
            +T+ L+K +++ +  L     E L     ++K++   L +    ++ L  + ++     D
Sbjct: 949  ETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQE---KMNLIQKSESFANYID 1005

Query: 238  VHRNGKYDMSPIH-QDKMNFIKEENLDGNLNEDIKSK------RISELEALVKK------ 284
                   ++S  + Q+K+  ++     GN  ED+  K      + S+LE L+ +      
Sbjct: 1006 EREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCE 1065

Query: 285  -----LLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSR 339
                 L   +E  +K H  F  K     +   +   + E   + +      +TD + +S+
Sbjct: 1066 NRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALR---SEMTDNQNNSK 1122

Query: 340  VPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCV-AKIQYLQNYL 398
                 L     T  E ++K ++    +   ++ ENE+  KV     +C   + + ++N +
Sbjct: 1123 SEAGGLKQEIMTLKEEQNKMQK----EVNDLLQENEQLMKVMKTKHECQNLESEPIRNSV 1178

Query: 399  KESVQIQ-----KKVMELESENLNLKSKMKPLIFTTQSLIQK---VETYEKQLKNLVEEK 450
            KE    +     K  M+LE + ++L S    L+     L  K   ++  EK+ + L  E 
Sbjct: 1179 KERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHEL 1238

Query: 451  STIQSKLS-------KTEEYS--KECL--KEFKKIISKYNVLQGQNKTLE-EKNIQLSLE 498
             TI+  L        +++E S  K+C    E K I   + +   QN     + ++Q ++ 
Sbjct: 1239 QTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMN 1298

Query: 499  KQQMMEALDQ-LKSKEHKTQSDMAIVNNE----NNRMSIEMEAMKTNILLIQDEKEMLE- 552
            K   +E + + L++++++  +++    +E      +M+ E+  +   + ++ D+  +L  
Sbjct: 1299 KLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHG 1358

Query: 553  ---------------KKTHQL----LKEKSS---LGNELKESQLEIIQLKEKERLAKTEQ 590
                            + H +    L E +S   L    KE Q+   +L+EK    ++E 
Sbjct: 1359 ELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEH 1418

Query: 591  ETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQ-----TYQSTAEENFLQEIK- 644
            + L      +  +   L+T +    A   ++   + N Q       Q   EE  +  +  
Sbjct: 1419 KILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSS 1478

Query: 645  ---------NAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEEL--KKHSQENI 693
                     ++  ++S Y+  L + G +  +LS +       NQ   +E+      +EN+
Sbjct: 1479 SCVPDSSSLSSLGDSSFYRALLEQTG-DMSLLSNLEGAVSA-NQCSVDEVFCSSLQEENL 1536

Query: 694  KFENSISR----LTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICN--QHND 747
              + + S     + E + L E Y +S+E   + +E +     +E   L   + +  Q  D
Sbjct: 1537 TRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELD 1596

Query: 748  PSKTTYISRREKF 760
              +  Y+S  E++
Sbjct: 1597 CLRKQYLSENEQW 1609



 Score = 36.6 bits (83), Expect = 0.094
 Identities = 57/307 (18%), Positives = 123/307 (40%), Gaps = 22/307 (7%)

Query: 433 IQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKN 492
           +QK++  E QL  L +EK   Q +L   E   +   K+ +K+         +N+  E  N
Sbjct: 17  LQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQ---KQKQKV---------ENEKTEGTN 64

Query: 493 IQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDE----K 548
             L  E Q++ME  + L+  + K   ++ +  ++ N    ++ + K  I  ++ E    K
Sbjct: 65  --LKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCK 122

Query: 549 EMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLE 608
             LE+          SL       ++    L   +  + ++ E L +      +E+  LE
Sbjct: 123 SELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLE 182

Query: 609 TTLQ--ESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEM 666
             ++  ++  A Q + +   N +        + +   +  K+ + +  NS     +    
Sbjct: 183 AEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFS 242

Query: 667 LSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFE 726
            S    E +        ++ K    +  F+NS S    D++  +N  + + N+ + LE  
Sbjct: 243 ASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQN--QELRNKINELELR 300

Query: 727 MRHLQRE 733
           ++  ++E
Sbjct: 301 LQGHEKE 307



 Score = 34.7 bits (78), Expect = 0.36
 Identities = 53/228 (23%), Positives = 87/228 (38%), Gaps = 25/228 (10%)

Query: 551 LEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETT 610
           LE +  +L KEK     +L   +  + + K+K    KTE   L +  + + +   +LE T
Sbjct: 23  LEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEKT 82

Query: 611 LQESTAARQIMEREIENIQTYQSTAE----ENFLQEIKNAKSEASIYKNSLSEIG---KE 663
            Q+ +   Q+ E ++ N Q  Q  +     E   QE+K  KSE    + +          
Sbjct: 83  KQKISHELQVKESQV-NFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNP 141

Query: 664 CEMLSKMVMETKTDNQI--------LKEELKKHSQENIKFENSISRLTEDKILLENYVRS 715
           C    K+     T +Q         LKE+  K  +E  + E  +  L + K   +   ++
Sbjct: 142 CNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKAL-QAKKASQTLPQA 200

Query: 716 IENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRREKFHFD 763
             N RD        + R   S S     Q   PS  +  S+R     D
Sbjct: 201 TMNHRD--------IARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRD 240


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
            sapiens]
          Length = 1870

 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 173/821 (21%), Positives = 336/821 (40%), Gaps = 104/821 (12%)

Query: 45   ESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKS-HHFEDSKTLH 103
            E EN+I  +S +K    +L   +  + Q  + +    E  E    +E   HH E    L 
Sbjct: 586  EKENKILHES-IKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELL 644

Query: 104  S---VEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRT--STDNLSSNIIIHPSENSDILK 158
                   K++ + + +L Q     S++  E+    +T  S  NL+  +     ENS + +
Sbjct: 645  QKKITNLKITCEKIEALEQE---NSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDE 701

Query: 159  NYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKS 218
                  R + +     M  A   + +K    +   K    + L+ +  S K+  E L+ S
Sbjct: 702  ENLELRRNVESLKCASMKMAQLQLENKE---LESEKEQLKKGLELLKASFKKT-ERLEVS 757

Query: 219  HDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNF-IKEENLDGNLNE-DIKSKRIS 276
            + G   L  E Q LQ   +   N    +  +  +  +  ++ + L  NL E  I SKR+ 
Sbjct: 758  YQG---LDIENQRLQKTLE---NSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLE 811

Query: 277  ELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKF 336
            +LE   K L      + K      ++ K+L +    +    E+NN +I    K    L  
Sbjct: 812  QLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSK 871

Query: 337  HSRVPRYTLSFLDQTKHEMKDKERQP------FLVKQGSIISENEKTSKVNSVTEQCVAK 390
               + + +   L + + E K+  ++        +  +  ++SE  KT ++N+  E+   +
Sbjct: 872  EIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHE 931

Query: 391  IQY-------------------------LQNYLKESVQI-QKKVMELES---ENLNLKSK 421
            ++                          L++ LK+S++I ++K+  LE+   E+ N   +
Sbjct: 932  LEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQ 991

Query: 422  MKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVL 481
            ++  + T +   + ++  + + + +V+    I  + +K E  S+E  +E  K+  +   +
Sbjct: 992  LRQELKTVKKNYEALKQRQDE-ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEV 1050

Query: 482  QGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNI 541
            +  N TL+ +   L  + +Q+    + L+++    Q     +  +N  +  +   ++   
Sbjct: 1051 ERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVEN 1110

Query: 542  LLIQDEKEMLEKKTHQLLKEKSSLGNE----LKESQ----LEIIQLKEKERL------AK 587
              +  +   L  +  QLL ++SSL NE    +KE +    L    +K+ E+L        
Sbjct: 1111 STLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQA 1170

Query: 588  TEQETLLQIIETVKDEKLNLETTLQE-STAARQIMER--EIENIQTYQSTAEENFLQEIK 644
            +E E+L+    T+K    NLE   ++      Q++++  ++E+++      +E  L E K
Sbjct: 1171 SEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENK 1230

Query: 645  NAKSEASIYKNSLSEIGKECEMLSKMVMET---KTDNQILKEELKKHSQENIKFENSISR 701
            N ++ A+ YK    E  +     S+++ ET   +TD++ LK  L     E  + E   S+
Sbjct: 1231 NHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSK 1290

Query: 702  LTED-------KILLENYVRSIENERDTLEFEMRHL--QREYLSLSDKICNQHNDPSK-- 750
            L E           L N    +   +  LE E RHL  Q + L L ++   + N  SK  
Sbjct: 1291 LKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDL 1350

Query: 751  -----TTYISR-------REKFH---FDNYTHEDTSSPQSR 776
                   YI +       +EK      D Y   D S P+ R
Sbjct: 1351 FHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRR 1391



 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 78/367 (21%), Positives = 167/367 (45%), Gaps = 39/367 (10%)

Query: 394 LQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTI 453
           L++ L+ +     K+ ELE ENL LK+K+         +  + +   K+++ L+EE  T+
Sbjct: 363 LEDQLEGTRARSDKLHELEKENLQLKAKL-------HDMEMERDMDRKKIEELMEENMTL 415

Query: 454 QSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTL--------EEKNIQLSLEKQQMMEA 505
           +    ++ + S     E ++I     + +   K+L          + ++L +E Q + + 
Sbjct: 416 EMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKT 475

Query: 506 LDQLKSKEHKTQ---SDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEK 562
           +++L++     +   S +  +  EN R+S ++E ++  I+  +   +  +  +  L+KEK
Sbjct: 476 VEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEK 535

Query: 563 SSLGNELKESQLEIIQLKEKERLAKTEQET--LLQIIETVKD-EKLNLETTLQESTAARQ 619
           + L     E  +E ++   + ++   EQE   L Q + +++   +++ E  +++     +
Sbjct: 536 AQL-----EKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENK 590

Query: 620 IMEREIENIQTYQSTAE------ENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVME 673
           I+   I+   +  S  E      +  L+  K     A   +N L  + KE E+L K +  
Sbjct: 591 ILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKI-- 648

Query: 674 TKTDNQILKEELKKHSQENIKFENSISRLTEDKILLEN---YVRSIENERDTLEFEMRHL 730
             T+ +I  E+++   QEN + E    +L +     +N    + S+E E   L+ E   L
Sbjct: 649 --TNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLEL 706

Query: 731 QREYLSL 737
           +R   SL
Sbjct: 707 RRNVESL 713



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 149/691 (21%), Positives = 284/691 (41%), Gaps = 145/691 (20%)

Query: 199 ENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIK 258
           E L DI    K   EEL++  D +V L  E +T+  D       + + +    DK++ ++
Sbjct: 334 ERLHDI-EFYKARVEELKE--DNQVLL--ETKTMLED-------QLEGTRARSDKLHELE 381

Query: 259 EENL-------DGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSK-SE 310
           +ENL       D  +  D+  K+I EL      L   ++      +H   + +++S+ SE
Sbjct: 382 KENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSE 441

Query: 311 MHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSI 370
           +    +    ++   +T   +  L+  ++        L +T  E++              
Sbjct: 442 LSEAPQKSLGHEVNELTSSRLLKLEMENQS-------LTKTVEELR-------------- 480

Query: 371 ISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENL-------NLKSKMK 423
                  + V+SV E   +KI  ++   KE+ ++ KKV  LE+E +       N ++  K
Sbjct: 481 -------TTVDSV-EGNASKILKME---KENQRLSKKVEILENEIVQEKQSLQNCQNLSK 529

Query: 424 PLIFTTQSLIQKVETY----EKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYN 479
            L+     L + +ET     E+Q+K L +E   +   +S   + S+   +   K I K N
Sbjct: 530 DLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKEN 589

Query: 480 -VLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMK 538
            +L    K    K  ++  EK+Q+ + L+  K K  + +     + NE + +  E E ++
Sbjct: 590 KILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEE----LENELHHLEKENELLQ 645

Query: 539 ---TNILLIQDEKEMLE-------------KKT-----------HQLLKEKSSLGNE--- 568
              TN+ +  ++ E LE             KKT             L KE S L  E   
Sbjct: 646 KKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLE 705

Query: 569 -------LKESQLEIIQLKEKERLAKTEQETLLQIIETVKD-----------------EK 604
                  LK + +++ QL+ + +  ++E+E L + +E +K                  E 
Sbjct: 706 LRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIEN 765

Query: 605 LNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKEC 664
             L+ TL+ S    Q +E E+++++    T ++N L+E+K +       +     + +E 
Sbjct: 766 QRLQKTLENSNKKIQQLESELQDLEMENQTLQKN-LEELKISSKRLEQLEKENKSLEQET 824

Query: 665 EMLSKMVMETKTDNQILKE--ELKKHSQE--NIKFEN----SISRLTEDKILLENYVRSI 716
             L K   + + +N+ L++  E+K  + E  N+K  N    + +   E  I  E+ VR  
Sbjct: 825 SQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLK 884

Query: 717 ENERDTLEFEMR---------HLQREYLSLSDKICNQHNDPSKTTYISRREKFHFDNYTH 767
           E E++  E   R          L+ + +S   K    +ND  K T+   +   + +   H
Sbjct: 885 ELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLH 944

Query: 768 EDTSSPQ-----SRPLASDLKGYFKVKDRTL 793
           ++ S+          L S LK   ++K+  +
Sbjct: 945 DEQSTDDRYKLLESKLESTLKKSLEIKEEKI 975



 Score = 70.1 bits (170), Expect = 8e-12
 Identities = 95/412 (23%), Positives = 185/412 (44%), Gaps = 65/412 (15%)

Query: 378 SKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVE 437
           +K+  + ++   K + L +  +E  Q++ ++  L+ EN+NL S  +        L   + 
Sbjct: 258 AKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDEL-DALR 316

Query: 438 TYEKQLKNLVEEKSTIQSKLSKTEEYSK--ECLKEFKKIISKYNVLQGQNKTLEEKNIQL 495
               ++  L  E S  + +L   E Y    E LKE  +++        + KT+ E  ++ 
Sbjct: 317 EKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLL-------ETKTMLEDQLEG 369

Query: 496 SLEKQQMMEALD----QLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEML 551
           +  +   +  L+    QLK+K H  +     +  + +R  IE E M+ N+ L   +K+ +
Sbjct: 370 TRARSDKLHELEKENLQLKAKLHDME-----MERDMDRKKIE-ELMEENMTLEMAQKQSM 423

Query: 552 EKKTH------QLLK-------EKSSLG---NELKESQLEIIQLKEKERLAKTEQE--TL 593
           ++  H      Q+ +        + SLG   NEL  S+L  +++ E + L KT +E  T 
Sbjct: 424 DESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEM-ENQSLTKTVEELRTT 482

Query: 594 LQIIETVKDEKLNLETTLQESTAARQIMEREI----ENIQTYQS---------------- 633
           +  +E    + L +E   Q  +   +I+E EI    +++Q  Q+                
Sbjct: 483 VDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTI 542

Query: 634 -TAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSK-MVMETKTDNQILKEELKKHSQE 691
            T  EN  ++IK  + E      ++S + +  ++ ++  V + + +N+IL E +K+ S +
Sbjct: 543 ETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSK 602

Query: 692 NIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICN 743
             K E    ++ ++   LE+Y    E   + LE E+ HL++E   L  KI N
Sbjct: 603 LSKIEFEKRQIKKE---LEHYKEKGERAEE-LENELHHLEKENELLQKKITN 650



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 55/207 (26%), Positives = 89/207 (42%), Gaps = 21/207 (10%)

Query: 530 MSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGN---ELKESQLEIIQLKEKERLA 586
           +S+E+   K  I  ++ E   LE+KT QLL  K  L     ELK  Q E + L    R A
Sbjct: 249 LSVELADAKAKIRRLRQE---LEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSA 305

Query: 587 KTEQETLLQIIE-TVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKN 645
           +  ++ L  + E  V+ +KL       ES  +R   +  + +I+ Y++  EE  L+E   
Sbjct: 306 RMYRDELDALREKAVRVDKL-------ESEVSR--YKERLHDIEFYKARVEE--LKEDNQ 354

Query: 646 AKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTED 705
              E    K  L +  +     S  + E + +N  LK +L     E       I  L E+
Sbjct: 355 VLLET---KTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEE 411

Query: 706 KILLENYVRSIENERDTLEFEMRHLQR 732
            + LE   +   +E   L +E+  + R
Sbjct: 412 NMTLEMAQKQSMDESLHLGWELEQISR 438


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
            sapiens]
          Length = 1843

 Score = 94.7 bits (234), Expect = 3e-19
 Identities = 173/822 (21%), Positives = 336/822 (40%), Gaps = 105/822 (12%)

Query: 45   ESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKS-HHFEDSKTLH 103
            E EN+I  +S +K    +L   +  + Q  + +    E  E    +E   HH E    L 
Sbjct: 586  EKENKILHES-IKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELL 644

Query: 104  S---VEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRT--STDNLSSNIIIHPSENSDILK 158
                   K++ + + +L Q     S++  E+    +T  S  NL+  +     ENS + +
Sbjct: 645  QKKITNLKITCEKIEALEQE---NSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDE 701

Query: 159  NYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKS 218
                  R + +     M  A   + +K    +   K    + L+ +  S K+  E L+ S
Sbjct: 702  ENLELRRNVESLKCASMKMAQLQLENKE---LESEKEQLKKGLELLKASFKKT-ERLEVS 757

Query: 219  HDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNF-IKEENLDGNLNE-DIKSKRIS 276
            + G   L  E Q LQ   +   N    +  +  +  +  ++ + L  NL E  I SKR+ 
Sbjct: 758  YQG---LDIENQRLQKTLE---NSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLE 811

Query: 277  ELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKF 336
            +LE   K L      + K      ++ K+L +    +    E+NN +I    K    L  
Sbjct: 812  QLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSK 871

Query: 337  HSRVPRYTLSFLDQTKHEMKDKERQP------FLVKQGSIISENEKTSKVNSVTEQCVAK 390
               + + +   L + + E K+  ++        +  +  ++SE  KT ++N+  E+   +
Sbjct: 872  EIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHE 931

Query: 391  IQY--------------------------LQNYLKESVQI-QKKVMELES---ENLNLKS 420
            ++                           L++ LK+S++I ++K+  LE+   E+ N   
Sbjct: 932  LEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQ 991

Query: 421  KMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNV 480
            +++  + T +   + ++  + + + +V+    I  + +K E  S+E  +E  K+  +   
Sbjct: 992  QLRQELKTVKKNYEALKQRQDE-ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIE 1050

Query: 481  LQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTN 540
            ++  N TL+ +   L  + +Q+    + L+++    Q     +  +N  +  +   ++  
Sbjct: 1051 VERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVE 1110

Query: 541  ILLIQDEKEMLEKKTHQLLKEKSSLGNE----LKESQ----LEIIQLKEKERL------A 586
               +  +   L  +  QLL ++SSL NE    +KE +    L    +K+ E+L       
Sbjct: 1111 NSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQ 1170

Query: 587  KTEQETLLQIIETVKDEKLNLETTLQE-STAARQIMER--EIENIQTYQSTAEENFLQEI 643
             +E E+L+    T+K    NLE   ++      Q++++  ++E+++      +E  L E 
Sbjct: 1171 ASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLEN 1230

Query: 644  KNAKSEASIYKNSLSEIGKECEMLSKMVMET---KTDNQILKEELKKHSQENIKFENSIS 700
            KN ++ A+ YK    E  +     S+++ ET   +TD++ LK  L     E  + E   S
Sbjct: 1231 KNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFS 1290

Query: 701  RLTED-------KILLENYVRSIENERDTLEFEMRHL--QREYLSLSDKICNQHNDPSK- 750
            +L E           L N    +   +  LE E RHL  Q + L L ++   + N  SK 
Sbjct: 1291 KLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKD 1350

Query: 751  ------TTYISR-------REKFH---FDNYTHEDTSSPQSR 776
                    YI +       +EK      D Y   D S P+ R
Sbjct: 1351 LFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRR 1392



 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 78/367 (21%), Positives = 167/367 (45%), Gaps = 39/367 (10%)

Query: 394 LQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTI 453
           L++ L+ +     K+ ELE ENL LK+K+         +  + +   K+++ L+EE  T+
Sbjct: 363 LEDQLEGTRARSDKLHELEKENLQLKAKL-------HDMEMERDMDRKKIEELMEENMTL 415

Query: 454 QSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTL--------EEKNIQLSLEKQQMMEA 505
           +    ++ + S     E ++I     + +   K+L          + ++L +E Q + + 
Sbjct: 416 EMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKT 475

Query: 506 LDQLKSKEHKTQ---SDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEK 562
           +++L++     +   S +  +  EN R+S ++E ++  I+  +   +  +  +  L+KEK
Sbjct: 476 VEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEK 535

Query: 563 SSLGNELKESQLEIIQLKEKERLAKTEQET--LLQIIETVKD-EKLNLETTLQESTAARQ 619
           + L     E  +E ++   + ++   EQE   L Q + +++   +++ E  +++     +
Sbjct: 536 AQL-----EKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENK 590

Query: 620 IMEREIENIQTYQSTAE------ENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVME 673
           I+   I+   +  S  E      +  L+  K     A   +N L  + KE E+L K +  
Sbjct: 591 ILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKI-- 648

Query: 674 TKTDNQILKEELKKHSQENIKFENSISRLTEDKILLEN---YVRSIENERDTLEFEMRHL 730
             T+ +I  E+++   QEN + E    +L +     +N    + S+E E   L+ E   L
Sbjct: 649 --TNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLEL 706

Query: 731 QREYLSL 737
           +R   SL
Sbjct: 707 RRNVESL 713



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 151/692 (21%), Positives = 286/692 (41%), Gaps = 146/692 (21%)

Query: 199 ENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIK 258
           E L DI    K   EEL++  D +V L  E +T+  D       + + +    DK++ ++
Sbjct: 334 ERLHDI-EFYKARVEELKE--DNQVLL--ETKTMLED-------QLEGTRARSDKLHELE 381

Query: 259 EENL-------DGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSK-SE 310
           +ENL       D  +  D+  K+I EL      L   ++      +H   + +++S+ SE
Sbjct: 382 KENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSE 441

Query: 311 MHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSI 370
           +    +    ++   +T   +  L+  ++        L +T  E++              
Sbjct: 442 LSEAPQKSLGHEVNELTSSRLLKLEMENQS-------LTKTVEELR-------------- 480

Query: 371 ISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENL-------NLKSKMK 423
                  + V+SV E   +KI  ++   KE+ ++ KKV  LE+E +       N ++  K
Sbjct: 481 -------TTVDSV-EGNASKILKME---KENQRLSKKVEILENEIVQEKQSLQNCQNLSK 529

Query: 424 PLIFTTQSLIQKVETY----EKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYN 479
            L+     L + +ET     E+Q+K L +E   +   +S   + S+   +   K I K N
Sbjct: 530 DLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKEN 589

Query: 480 -VLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMK 538
            +L    K    K  ++  EK+Q+ + L+  K K  + +     + NE + +  E E ++
Sbjct: 590 KILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEE----LENELHHLEKENELLQ 645

Query: 539 ---TNILLIQDEKEMLE-------------KKT-----------HQLLKEKSSLGNE--- 568
              TN+ +  ++ E LE             KKT             L KE S L  E   
Sbjct: 646 KKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLE 705

Query: 569 -------LKESQLEIIQLKEKERLAKTEQETLLQIIETVKD-----------------EK 604
                  LK + +++ QL+ + +  ++E+E L + +E +K                  E 
Sbjct: 706 LRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIEN 765

Query: 605 LNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKEC 664
             L+ TL+ S    Q +E E+++++    T ++N L+E+K +       +     + +E 
Sbjct: 766 QRLQKTLENSNKKIQQLESELQDLEMENQTLQKN-LEELKISSKRLEQLEKENKSLEQET 824

Query: 665 EMLSKMVMETKTDNQILKE--ELKKHSQE--NIKFEN----SISRLTEDKILLENYVRSI 716
             L K   + + +N+ L++  E+K  + E  N+K  N    + +   E  I  E+ VR  
Sbjct: 825 SQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLK 884

Query: 717 ENERDTLEFEMR---------HLQREYLSLSDKICNQHNDPSKTTYISRREKFHFDNYTH 767
           E E++  E   R          L+ + +S   K    +ND  K T+   +   + +   H
Sbjct: 885 ELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLH 944

Query: 768 EDTSSPQSR------PLASDLKGYFKVKDRTL 793
           ++ S+  SR       L S LK   ++K+  +
Sbjct: 945 DEQSTDDSRYKLLESKLESTLKKSLEIKEEKI 976



 Score = 70.1 bits (170), Expect = 8e-12
 Identities = 95/412 (23%), Positives = 185/412 (44%), Gaps = 65/412 (15%)

Query: 378 SKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVE 437
           +K+  + ++   K + L +  +E  Q++ ++  L+ EN+NL S  +        L   + 
Sbjct: 258 AKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDEL-DALR 316

Query: 438 TYEKQLKNLVEEKSTIQSKLSKTEEYSK--ECLKEFKKIISKYNVLQGQNKTLEEKNIQL 495
               ++  L  E S  + +L   E Y    E LKE  +++        + KT+ E  ++ 
Sbjct: 317 EKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLL-------ETKTMLEDQLEG 369

Query: 496 SLEKQQMMEALD----QLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEML 551
           +  +   +  L+    QLK+K H  +     +  + +R  IE E M+ N+ L   +K+ +
Sbjct: 370 TRARSDKLHELEKENLQLKAKLHDME-----MERDMDRKKIE-ELMEENMTLEMAQKQSM 423

Query: 552 EKKTH------QLLK-------EKSSLG---NELKESQLEIIQLKEKERLAKTEQE--TL 593
           ++  H      Q+ +        + SLG   NEL  S+L  +++ E + L KT +E  T 
Sbjct: 424 DESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEM-ENQSLTKTVEELRTT 482

Query: 594 LQIIETVKDEKLNLETTLQESTAARQIMEREI----ENIQTYQS---------------- 633
           +  +E    + L +E   Q  +   +I+E EI    +++Q  Q+                
Sbjct: 483 VDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTI 542

Query: 634 -TAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSK-MVMETKTDNQILKEELKKHSQE 691
            T  EN  ++IK  + E      ++S + +  ++ ++  V + + +N+IL E +K+ S +
Sbjct: 543 ETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSK 602

Query: 692 NIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICN 743
             K E    ++ ++   LE+Y    E   + LE E+ HL++E   L  KI N
Sbjct: 603 LSKIEFEKRQIKKE---LEHYKEKGERAEE-LENELHHLEKENELLQKKITN 650



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 55/207 (26%), Positives = 89/207 (42%), Gaps = 21/207 (10%)

Query: 530 MSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGN---ELKESQLEIIQLKEKERLA 586
           +S+E+   K  I  ++ E   LE+KT QLL  K  L     ELK  Q E + L    R A
Sbjct: 249 LSVELADAKAKIRRLRQE---LEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSA 305

Query: 587 KTEQETLLQIIE-TVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKN 645
           +  ++ L  + E  V+ +KL       ES  +R   +  + +I+ Y++  EE  L+E   
Sbjct: 306 RMYRDELDALREKAVRVDKL-------ESEVSR--YKERLHDIEFYKARVEE--LKEDNQ 354

Query: 646 AKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTED 705
              E    K  L +  +     S  + E + +N  LK +L     E       I  L E+
Sbjct: 355 VLLET---KTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEE 411

Query: 706 KILLENYVRSIENERDTLEFEMRHLQR 732
            + LE   +   +E   L +E+  + R
Sbjct: 412 NMTLEMAQKQSMDESLHLGWELEQISR 438


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score = 94.0 bits (232), Expect = 5e-19
 Identities = 168/792 (21%), Positives = 334/792 (42%), Gaps = 110/792 (13%)

Query: 24   LNSSEGVKESGCSDTE-YGCIAESENQIQPQSALKVLQQQ-LES-FQALRMQ----TLQN 76
            +N    + ES CS+++ +    ++ ++I+   A K+L Q+ +ES   +LR       L  
Sbjct: 455  INLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDY 514

Query: 77   VSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLR 136
              + TE +E  L +++ +  ++ + L   E K   D    L   ++    +     +  +
Sbjct: 515  EQLRTEKEEMELKLKEKNDLDEFEAL---ERKTKKDQEMQLIHEISNLKNLVKHAEVYNQ 571

Query: 137  TSTDNLSSNIIIHPSENSDILKNYNNF--------------YRFLPTAPPNVMSQ----A 178
               + LSS + +   E  D +K    +              Y       P  M Q    A
Sbjct: 572  DLENELSSKVELL-REKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDA 630

Query: 179  DTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDV 238
            +TV LD  + +  FL+    ENL+        +KE++++       + N++Q  Q+  + 
Sbjct: 631  ETVALDAKRESA-FLRS---ENLE--------LKEKMKELATTYKQMENDIQLYQSQLEA 678

Query: 239  HRNGKYDMSPIHQDKMNFIKEEN--LDGNLNEDIK----------------SKRISELEA 280
             +  + D+    Q   N I +    +DG + +D+                 +K + E EA
Sbjct: 679  KKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEA 738

Query: 281  LVKKLLPFRETVS-KFHVHFCRKCKKLSKSEMHR-GKKNEKNNKEIPITGKNITDLKFHS 338
            L ++++   E  S    V   RK  +    E+H    + +K   E+      +  L    
Sbjct: 739  LREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEI 798

Query: 339  RVPRYTLSFLDQTKHEMKDKERQPFLV-------KQGSIISENEKTSKVNSVTEQCVAKI 391
               +  L+   Q+ ++  D+E Q F         K   ++ ENE+ ++      +   K 
Sbjct: 799  GKTKDDLA-TTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKF 857

Query: 392  QYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKS 451
                  LK   ++  K  EL+ +   ++ ++  +    + L +++E  +  L+ +  EK+
Sbjct: 858  DSSLGALK--TELSYKTQELQEKTREVQERLNEM----EQLKEQLENRDSTLQTVEREKT 911

Query: 452  TIQSKLSKTEEYSKECLKE---FKKIISKYNVLQGQNKTLEEKNIQLSLEKQ-QMMEALD 507
             I  KL +T E  K   +E    K++     + + Q K+     + ++++ Q Q+  AL+
Sbjct: 912  LITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALE 971

Query: 508  QLKSKEHKTQSDMAIVNNENNR-MSIEMEAMKTNILLIQ-----DEKEMLEKKTHQLLKE 561
             LK  +    +  + ++ E +R + +E    +T     Q     D+K+ LE K  Q L  
Sbjct: 972  SLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTA 1031

Query: 562  KSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIM 621
                 NE+ E Q +I  L +       E+  L Q++E+V  EK  L+T L+E+      +
Sbjct: 1032 DVK-DNEIIEQQRKIFSLIQ-------EKNELQQMLESVIAEKEQLKTDLKEN------I 1077

Query: 622  EREIENIQTYQSTAEE-NFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQI 680
            E  IEN +  +   +E    QEI   +   +I K    E+ + C+ L+++  + K  +Q 
Sbjct: 1078 EMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEG--ELSRTCDRLAEVEEKLKEKSQQ 1135

Query: 681  LKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDK 740
            L+E+     Q+ +  +  +S + + KI   N + +++NE    E  + H++ E L L+ K
Sbjct: 1136 LQEK----QQQLLNVQEEMSEM-QKKI---NEIENLKNELKNKELTLEHMETERLELAQK 1187

Query: 741  ICNQHNDPSKTT 752
            +   + +    T
Sbjct: 1188 LNENYEEVKSIT 1199



 Score = 89.7 bits (221), Expect = 9e-18
 Identities = 153/715 (21%), Positives = 295/715 (41%), Gaps = 104/715 (14%)

Query: 45   ESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHS 104
            E +N    + AL+V   QL+  + +R +TL  +      QE++L+M++    +D++T   
Sbjct: 1350 ERDNLKTIKEALEVKHDQLK--EHIR-ETLAKIQESQSKQEQSLNMKE----KDNETTKI 1402

Query: 105  VEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTD--NLSSNIIIHPSENSDILKNYNN 162
            V E                  Q   +D+  LR   +   LS  +     E   + K  ++
Sbjct: 1403 VSEM----------------EQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDD 1446

Query: 163  FYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHS-IKQMKEELQKSHDG 221
              R        + S++D +   K  I     KH   E    + H  +K+ +E + +    
Sbjct: 1447 LQRLQEV----LQSESDQL---KENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVN 1499

Query: 222  EVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEAL 281
                  E+ T+Q   +   N K       Q+K+  I E+       E    K+ISE++  
Sbjct: 1500 LSEKETEISTIQKQLEAI-NDKL------QNKIQEIYEKE------EQFNIKQISEVQEK 1546

Query: 282  VKKLLPFRETVSKFHVHFCRKCK-----KLSKSEMHRGKKNEKNNKEIPITGKNITDLKF 336
            V +L  F+E          RK K      +    +    + +++ +EI I  K   ++K 
Sbjct: 1547 VNELKQFKEH---------RKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMK- 1596

Query: 337  HSRVPRYTLSFLDQTKHEMKD--------KERQPFLVKQGSIISENEKTSKVNSVTEQCV 388
              RV        DQ K   K+        +E++   +K  ++    EK  ++  + EQ  
Sbjct: 1597 --RVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFE 1654

Query: 389  AKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVE 448
             +   L+N   E++++ + + E   E  ++  +   L    ++L  KVE    QLK  + 
Sbjct: 1655 TQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETL--KVE--RDQLKENLR 1710

Query: 449  EKSTIQSKLSKTEEYS--KECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEAL 506
            E  TI   L K EE       LKE ++ I K   +  + KT E  N+Q  LE        
Sbjct: 1711 E--TITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSE-KTNEISNMQKDLEHSN----- 1762

Query: 507  DQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLG 566
            D LK+++ K Q ++ I +         ++ ++  +    D+   ++K       +     
Sbjct: 1763 DALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKI 1822

Query: 567  NELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIE 626
             ELK ++ ++I LK+     + +   + Q+ + +KD+ L L              + EIE
Sbjct: 1823 QELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLS-------------KLEIE 1869

Query: 627  NIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELK 686
            N+   Q   E   L+E+K+   E    +     +  E + L + + ETK  +  +++ELK
Sbjct: 1870 NLNLAQKLHEN--LEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELK 1927

Query: 687  KHSQENIKFENSISRL----TEDKILLENYVRSIENERDTLEFEMRHLQREYLSL 737
                 + + + ++ +L    +E  I + +  + ++  +D L+ +++ LQ++ L L
Sbjct: 1928 TARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQL 1982



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 164/752 (21%), Positives = 311/752 (41%), Gaps = 108/752 (14%)

Query: 59   LQQQLESFQA----LRMQTLQNVSMPTENQEEN-------------LSMEKSHHF----E 97
            LQQ LES  A    L+    +N+ M  ENQEE              ++ EK+H      E
Sbjct: 1055 LQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGE 1114

Query: 98   DSKT---LHSVEEKLSGDSVN---SLPQSVNVPSQIHS-----EDTLTLRTSTDNLSSNI 146
             S+T   L  VEEKL   S        Q +NV  ++        +   L+    N    +
Sbjct: 1115 LSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTL 1174

Query: 147  IIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICH 206
                +E  ++ +  N  Y  + +             + K +  +  L+  F    D +  
Sbjct: 1175 EHMETERLELAQKLNENYEEVKS-------------ITKERKVLKELQKSFETERDHLRG 1221

Query: 207  SIKQMKEE-LQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGN 265
             I++++   LQ   + ++A  +  +  +T  ++ R+     + I    +N    E     
Sbjct: 1222 YIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQI----INTQDLEKSHTK 1277

Query: 266  LNEDIKS-KRISELEALVKKLLPFRETVSKFHVHFCRKCKK----LSKSEMHRGKKNEK- 319
            L E+I       EL   VK++   +ET+++  +   +   K    L++ EM R + NEK 
Sbjct: 1278 LQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKF 1337

Query: 320  --NNKEIPITGKNITDLKF--------HSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGS 369
              + +EI    K   +LK         H ++  +    L + + E + K+ Q   +K+  
Sbjct: 1338 QESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQ-ESQSKQEQSLNMKEKD 1396

Query: 370  -----IISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVME-----------LES 413
                 I+SE E+    +S   +   ++  L   L+ES    K V +           L+S
Sbjct: 1397 NETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQS 1456

Query: 414  ENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKK 473
            E+  LK  +K ++       ++++     LK   E  + ++  LS+ E       K+ + 
Sbjct: 1457 ESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEA 1516

Query: 474  IISKY-NVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSI 532
            I  K  N +Q   +  E+ NI+   E Q+ +  L Q   KEH+   D A+ + E+  + +
Sbjct: 1517 INDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQF--KEHRKAKDSALQSIESKMLEL 1574

Query: 533  --EMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKE-----RL 585
               ++  +  I ++  EKE +++    L  E+  L    KE   ++ + +EKE       
Sbjct: 1575 TNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMT 1634

Query: 586  AKTEQETLLQIIETVKD----EKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQ 641
            A  E +  +  IE +K+    +KLNLE    E+    QI+    EN++  +S  +E    
Sbjct: 1635 AVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILH---ENLEEMRSVTKER--D 1689

Query: 642  EIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISR 701
            ++++ +    + ++ L E  +E        +E + + +I+   LK+H +   K    +S 
Sbjct: 1690 DLRSVEETLKVERDQLKENLRETITRD---LEKQEELKIVHMHLKEHQETIDKLRGIVSE 1746

Query: 702  LTEDKILLENYVRSIENERDTLEFEMRHLQRE 733
             T +   + N  + +E+  D L+ +   +Q E
Sbjct: 1747 KTNE---ISNMQKDLEHSNDALKAQDLKIQEE 1775



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 152/742 (20%), Positives = 304/742 (40%), Gaps = 116/742 (15%)

Query: 53   QSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGD 112
            QS  K   Q+ ++F+ L M   Q   M  E + E ++ E  +  ++++   S        
Sbjct: 809  QSNYKSTDQEFQNFKTLHMDFEQKYKMVLE-ENERMNQEIVNLSKEAQKFDS-------- 859

Query: 113  SVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPP 172
            S+ +L   ++  +Q   E T  ++   + +    +    EN D              +  
Sbjct: 860  SLGALKTELSYKTQELQEKTREVQERLNEMEQ--LKEQLENRD--------------STL 903

Query: 173  NVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTL 232
              + +  T+I +K + T+  +K    +  DD+    KQ++E LQ   D   +  ++   +
Sbjct: 904  QTVEREKTLITEKLQQTLEEVKT-LTQEKDDL----KQLQESLQIERDQLKSDIHDTVNM 958

Query: 233  QTDPDVHRNGKYDMSPIHQDKMNFIKE---ENLDGNLN---------------------- 267
              D         +    HQ+ +N +K    E +  NL+                      
Sbjct: 959  NIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKK 1018

Query: 268  EDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNN------ 321
            +D+++K    L A VK      E + +    F    +K    +M      EK        
Sbjct: 1019 QDLEAKNTQTLTADVKD----NEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLK 1074

Query: 322  KEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVN 381
            + I +T +N  +L+      +     + Q K+    KE +  L +    ++E E+  K+ 
Sbjct: 1075 ENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGE--LSRTCDRLAEVEE--KLK 1130

Query: 382  SVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSL-IQKVETYE 440
              ++Q   K Q L N  +E  ++QKK+ E+E    NLK+++K    T + +  +++E  +
Sbjct: 1131 EKSQQLQEKQQQLLNVQEEMSEMQKKINEIE----NLKNELKNKELTLEHMETERLELAQ 1186

Query: 441  KQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQ 500
            K  +N  E KS     ++K  +  KE  K F+   ++ + L+G  + +E   +Q   E +
Sbjct: 1187 KLNENYEEVKS-----ITKERKVLKELQKSFE---TERDHLRGYIREIEATGLQTKEELK 1238

Query: 501  QMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLK 560
                 +  +  KEH+   D      E  R   E  A   N   ++     L+++   L +
Sbjct: 1239 -----IAHIHLKEHQETID------ELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHE 1287

Query: 561  EKSSLGN--ELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAAR 618
            E+  L N  E+ E+Q  + +L+     + T+  T L  IE    E+L L    QES    
Sbjct: 1288 EQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEM---ERLRLNEKFQESQEEI 1344

Query: 619  QIMEREIENIQTYQSTAE----------ENFLQEIKNAKSEASIYKNSLSEIGKECEMLS 668
            + + +E +N++T +   E             L +I+ ++S+     N   +  +  +++S
Sbjct: 1345 KSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVS 1404

Query: 669  KMVMETKTDNQILKEE-----LKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTL 723
            +M      D+ +L+ E     L K  QE+     S+++  +D   L+     +++E D L
Sbjct: 1405 EMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDD---LQRLQEVLQSESDQL 1461

Query: 724  EFEMRHLQREYLSLSDKICNQH 745
            +  ++ +  ++L   +++   H
Sbjct: 1462 KENIKEIVAKHLETEEELKVAH 1483



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 140/639 (21%), Positives = 284/639 (44%), Gaps = 104/639 (16%)

Query: 208  IKQMKEEL--QKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMN---FIKEENL 262
            IK+++E +  QK  + ++ L+  L++++ DP   +   +D   +  D      F++ ENL
Sbjct: 591  IKKLQEYIDSQKLENIKMDLSYSLESIE-DPKQMKQTLFDAETVALDAKRESAFLRSENL 649

Query: 263  DGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKN-N 321
            +  L E +K     EL    K++                   +L +S++   KK + +  
Sbjct: 650  E--LKEKMK-----ELATTYKQM---------------ENDIQLYQSQLEAKKKMQVDLE 687

Query: 322  KEIPITGKNITDLK--FHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSK 379
            KE+      IT L      +VP+  L  L+    E K  + Q  L K+   + ENE    
Sbjct: 688  KELQSAFNEITKLTSLIDGKVPKDLLCNLEL---EGKITDLQKELNKE---VEENE---- 737

Query: 380  VNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETY 439
                  + V  +  L++   E  +++K++ + +SE L++ +  K  +F+      +V   
Sbjct: 738  ---ALREEVILLSELKSLPSEVERLRKEIQD-KSEELHIITSEKDKLFS------EVVHK 787

Query: 440  EKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIIS-------KYNVLQGQNKTLEEKN 492
            E +++ L+EE    +  L+ T+   K   +EF+   +       KY ++  +N+ + ++ 
Sbjct: 788  ESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEI 847

Query: 493  IQLSLEKQQMMEALDQLKSK-EHKTQS------DMAIVNNENNRMSIEMEAMKTNILLIQ 545
            + LS E Q+   +L  LK++  +KTQ       ++    NE  ++  ++E   + +  ++
Sbjct: 848  VNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVE 907

Query: 546  DEKEMLEKKTHQLLKEKSSLGNE---LKESQLEIIQLKEKERLAKTEQETLLQIIETVKD 602
             EK ++ +K  Q L+E  +L  E   LK+ Q E +Q+ E+++L     +T+   I+T + 
Sbjct: 908  REKTLITEKLQQTLEEVKTLTQEKDDLKQLQ-ESLQI-ERDQLKSDIHDTVNMNIDTQEQ 965

Query: 603  EKLNLETTLQE----STAARQIMEREIENIQTYQSTAE--ENFLQ-----------EIKN 645
             +  LE+  Q     +T   +I E    N+   ++T E  + F Q           E KN
Sbjct: 966  LRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKN 1025

Query: 646  AKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQIL------KEELKKHSQENIKFENSI 699
             ++  +  K+  +EI ++   +  ++ E     Q+L      KE+LK   +ENI  E +I
Sbjct: 1026 TQTLTADVKD--NEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENI--EMTI 1081

Query: 700  SRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLS---DKICNQHNDPSKTTYISR 756
                E ++L +     ++ +++ +  E  H  ++   LS   D++        + +   +
Sbjct: 1082 ENQEELRLLGD----ELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQ 1137

Query: 757  REKFHFDNYTHEDTSSPQSRPLASDLKGYFKVKDRTLKH 795
             ++    N   E +   +      +LK   K K+ TL+H
Sbjct: 1138 EKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEH 1176



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 117/623 (18%), Positives = 247/623 (39%), Gaps = 92/623 (14%)

Query: 210  QMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNED 269
            Q+KE LQ++   ++ +  EL+T +     H+     +     +K   I +   D + ++D
Sbjct: 1907 QLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKD 1966

Query: 270  IKSKRISELEALVKKLLPFRETVSKFH--VHFCRKCKKLSKSE-----------MHRGKK 316
               K+I EL+    +LL  +E V+  H  ++   + KK  +++               KK
Sbjct: 1967 ELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKK 2026

Query: 317  NEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEK 376
              ++ +EI I  K   +L+      +        T  EM  ++RQ   VK    +  + +
Sbjct: 2027 LHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQ 2086

Query: 377  TSKVNSVTEQCVAKIQYLQNY----------------LKESVQIQKKVMELESENLNLKS 420
                 S+ E+C    + L+ Y                L++ ++ QK++      NL+L  
Sbjct: 2087 QHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPY 2146

Query: 421  KMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEF--------- 471
                 I   + L    +    +   ++++   + S ++K +E   E + +F         
Sbjct: 2147 LQTKHI---EKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVE 2203

Query: 472  --KKIISKYNVLQ---------------GQNKTLEEKNI----------QLSLEKQQMM- 503
              K+++ K   LQ                QN  L  + I           +  E QQ++ 
Sbjct: 2204 KQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLS 2263

Query: 504  --EALDQLKSKEHKTQSDMAIVNN----ENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQ 557
              + + Q   +   T+ D+  + N    EN+R+          I+ I +E    E+++  
Sbjct: 2264 NRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSAT 2323

Query: 558  LLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAA 617
            + KE       LKE   ++ +     +  KT   +  Q+  T +D K    T+       
Sbjct: 2324 ISKEWEQDLKSLKEKNEKLFK---NYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTT 2380

Query: 618  RQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTD 677
             +I  RE+EN       +  +   +I   + E  +  + ++++  +    +K + +TK  
Sbjct: 2381 EKI--RELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKET 2438

Query: 678  NQILKEEL----KKHSQENIKFENSISRLTEDKIL-LENYVRSIENERDTLEF--EMRHL 730
             Q+L++++    K + +E    +  + ++  +K+   + + + I   + T+E+  E+  L
Sbjct: 2439 IQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRL 2498

Query: 731  QREYLSLSDK-----ICNQHNDP 748
             RE L  S +     + ++H DP
Sbjct: 2499 LRENLRRSQQAQDTSVISEHTDP 2521



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 149/787 (18%), Positives = 325/787 (41%), Gaps = 128/787 (16%)

Query: 1    MSPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQ 60
            +S  +Q +++ +  S+ LS  +I N +   K     +     + E +N  + +  LK+ +
Sbjct: 1846 VSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLER 1905

Query: 61   QQL-ESFQALR------MQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDS 113
             QL ES Q  +       Q L+   M ++  +E +   +    E +  +  +++ L   S
Sbjct: 1906 DQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLD-KS 1964

Query: 114  VNSLPQSVNVPSQIHSEDTLTLRTSTD-NLSSNIIIHPSENSDILKNYNNFYRFLPTAPP 172
             + L + +    ++  ++   LR   D N+S   I   +E   + K +            
Sbjct: 1965 KDELQKKIQ---ELQKKELQLLRVKEDVNMSHKKI---NEMEQLKKQFE---------AQ 2009

Query: 173  NVMSQADTVILDKSKITVPFLKHGFCENLDDICHS---IKQMKEELQKSHDGEVALTNEL 229
            N+  Q+  V +D  ++T     H   E +  +      ++++KE L+   D  +A   E+
Sbjct: 2010 NLSMQS--VRMDNFQLTKKL--HESLEEIRIVAKERDELRRIKESLKMERDQFIATLREM 2065

Query: 230  -----QTLQTDPDVH--RNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALV 282
                 Q  Q  P+     +G+  ++   ++K + IKE             KR SE++   
Sbjct: 2066 IARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKE-----------LLKRYSEMDDHY 2114

Query: 283  KKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPR 342
            + L      + K  + F ++     K+ +       K+ +++  T      ++FH  + +
Sbjct: 2115 ECLNRLSLDLEK-EIEFQKELSMRVKANLSLPYLQTKHIEKL-FTANQRCSMEFHRIMKK 2172

Query: 343  --YTLSFLDQTK---HEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNY 397
              Y LS++ + K   HE  +K    F+     +  + E   K+  + + C    + L++ 
Sbjct: 2173 LKYVLSYVTKIKEEQHESINKFEMDFI---DEVEKQKELLIKIQHLQQDCDVPSRELRD- 2228

Query: 398  LKESVQIQKKVMEL-----ESENLNLKSKMKPLIFTTQSLIQKVETYE------KQLKNL 446
            LK +  +   + E+     ESE  ++K++ + ++   + + Q +E +       ++LKN 
Sbjct: 2229 LKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNG 2288

Query: 447  VEEKS---------------TIQSKLSKTEEYSKECLKEFK-----------KIISKYNV 480
            +++++                I ++ ++ EE S    KE++           K+   Y  
Sbjct: 2289 IQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQT 2348

Query: 481  L--------QGQNKTLEEKNIQLSLEKQQMM-EALDQLKSKEHKTQSDMAIVNNENNRMS 531
            L        Q    T + KN  ++    Q+  E + +L++  H+ +       ++  +M 
Sbjct: 2349 LKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQ 2408

Query: 532  IEMEAMKTNILLIQ----DEKEMLEK--KTHQLLKEKSSLGNELKESQLEIIQLK----- 580
             E+E     I  +Q    +  + LEK  +T Q+L++K +LG +  + ++E +++K     
Sbjct: 2409 KELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKID 2468

Query: 581  -EKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEE-- 637
             EK + AK  ++ +     TV+ +K  +    +    ++Q  +  + +  T    + +  
Sbjct: 2469 LEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPL 2528

Query: 638  ------NFLQEIKNA--KSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHS 689
                    +Q  K    KSE    +  +S++ ++ E L K   E  ++NQ L  E+K   
Sbjct: 2529 TCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWK 2588

Query: 690  QENIKFE 696
            +  +K E
Sbjct: 2589 ERTLKRE 2595



 Score = 36.2 bits (82), Expect = 0.12
 Identities = 49/209 (23%), Positives = 91/209 (43%), Gaps = 26/209 (12%)

Query: 569 LKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENI 628
           LK  + EI+ LK++  L +   ET  Q +E  KD+   L   L+E    +++   +IEN+
Sbjct: 345 LKRYRKEIMDLKKQ--LEEVSLETRAQAME--KDQLAQL---LEEKDLLQKVQNEKIENL 397

Query: 629 QTYQSTAEENFLQEIKNAKSE-------ASIYKNSLSEIGKECEMLSKMVMET-KTDNQI 680
                T+    LQ+   AK +         I K   S    +  + + +  +T K    +
Sbjct: 398 TRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINL 457

Query: 681 LKEELKKHSQENIKFENSISRLTE------DKIL----LENYVRSIENERDTLEFEMRHL 730
           L+E  +    E+  F N++  L+E       K+L    +E+ + S+  + D L  +   L
Sbjct: 458 LREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQL 517

Query: 731 QREYLSLSDKICNQHNDPSKTTYISRREK 759
           + E   +  K+  + ND  +   + R+ K
Sbjct: 518 RTEKEEMELKL-KEKNDLDEFEALERKTK 545


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 93.2 bits (230), Expect = 8e-19
 Identities = 184/845 (21%), Positives = 351/845 (41%), Gaps = 152/845 (17%)

Query: 1    MSPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGC-IAESENQIQPQSAL--- 56
            +S EK   +E +V  + L  S++    E +KE   + TE    + +++ Q Q Q AL   
Sbjct: 443  LSSEKLMDKEQQVADLQLKLSRL---EEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQS 499

Query: 57   ---KVLQQQLESFQALRM-----QTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEK 108
               K+ + Q +  Q LR      Q +QN+    +  +EN+S+ +    ++ + L++  + 
Sbjct: 500  TTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLE----KEREDLYAKIQA 555

Query: 109  LSGDS--VNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRF 166
              G++  +N L +  +   +  ++ T  L+  +++       H     ++          
Sbjct: 556  GEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSES-------HKQAQENLHDQVQEQKAH 608

Query: 167  LPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALT 226
            L  A   V+S   +V    S++          E+ + +     Q+K + +     E A T
Sbjct: 609  LRAAQDRVLSLETSVNELNSQLN---------ESKEKVSQLDIQIKAKTELLLSAEAAKT 659

Query: 227  NELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLL 286
             +   LQ   D  +N   D            K++ L+         K  ++L+ +  KL 
Sbjct: 660  AQRADLQNHLDTAQNALQD------------KQQELN---------KITTQLDQVTAKLQ 698

Query: 287  PFRETVSKFHVHFCR-KCKKLS---KSEMHRG--KKNEKNNKEIPITGKN-ITDLKFHSR 339
              +E  S+   H    K K LS   K+E   G  KK E ++ E+  + +  + DL+   +
Sbjct: 699  DKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQ 758

Query: 340  VPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISEN----EKTSKVNSVTEQCVAKIQYLQ 395
            +          T  E++  E    L  +  I+S      +K S+     +Q + K +  +
Sbjct: 759  L---------NTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEK 809

Query: 396  NYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQS 455
              LK+  +   +  +++ E LN +      I TT + +QKV+  EK+   L+ E ST++ 
Sbjct: 810  QILKQDFETLSQETKIQHEELNNR------IQTTVTELQKVKM-EKEA--LMTELSTVKD 860

Query: 456  KLSKTEEYSKECLKEFKKIISKYNV-----------------LQGQNKTLEEKNIQLSLE 498
            KLSK  +  K    EF+K   K                    +Q +N   E+K ++ SLE
Sbjct: 861  KLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLE 920

Query: 499  KQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQL 558
            K++  EA  QLK + +  Q  +    N   +   E + ++ NI  ++   E  +K+   L
Sbjct: 921  KEK--EASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEAL 978

Query: 559  LKE-------KSSLGNELKESQLEIIQ--LKEKERLA------KTEQETLLQIIETVKDE 603
              E       K+ L N+L++   +  Q    EKE+++      +  QET  Q+       
Sbjct: 979  QGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGR 1038

Query: 604  KLNLETTLQESTAARQIMEREIENIQTYQSTA--EENFLQEIKNAKS---------EASI 652
            +  L  T Q+  +  + +    E++ + ++    +   +QE+K AK+         E  +
Sbjct: 1039 ESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQL 1098

Query: 653  YKN--SLSEIGKECEMLSKMVMETKT------------DNQILK--EELKKHSQENIKFE 696
             +   +L +I KE  +  K ++  K+            + +I K  EELK H  E+IK  
Sbjct: 1099 QERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIK-- 1156

Query: 697  NSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISR 756
              I+ L + K LL      ++ + D+L+  +   +R    L D++  +  +  K  +I +
Sbjct: 1157 -EITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQV-KKEEEELKKEFIEK 1214

Query: 757  REKFH 761
              K H
Sbjct: 1215 EAKLH 1219



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 153/694 (22%), Positives = 288/694 (41%), Gaps = 101/694 (14%)

Query: 12   EVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQQLESFQALRM 71
            E DS+ + ASK         E    D +      ++ +++     K L+ + E   + R+
Sbjct: 736  EADSLEVKASK---------EQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRL 786

Query: 72   ------QTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPS 125
                  + L+++      QEE   + K    +D +TL S E K+  + +N+  Q+     
Sbjct: 787  DLQKKSEALESIKQKLTKQEEEKQILK----QDFETL-SQETKIQHEELNNRIQTTVTEL 841

Query: 126  QIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDK 185
            Q    +   L T    +   +    S+ SD LKN  + +            +    ILD 
Sbjct: 842  QKVKMEKEALMTELSTVKDKL----SKVSDSLKNSKSEFE-------KENQKGKAAILDL 890

Query: 186  SKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYD 245
             K T   LKH     +++     K++K+ L+K  +    L  EL ++Q      +N    
Sbjct: 891  EK-TCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTL-- 947

Query: 246  MSPIHQDKMNFIKEENLDGNLNE-----DIKSKRISELEALVK-KLLPFRETVSKFHVHF 299
                   K N  +E+ L GN+NE     + K K+I  L+  +K  +L   E  +K     
Sbjct: 948  -------KQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQL 1000

Query: 300  CRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKE 359
             +  ++L+ +E  +    + N ++   T K +    F+ R      S L  T+ ++K  E
Sbjct: 1001 TQAAQELA-AEKEKISVLQNNYEKSQETFKQLQS-DFYGRE-----SELLATRQDLKSVE 1053

Query: 360  RQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLK 419
             +  L ++  I + N+  ++   + E   AK    Q+  K+  Q+Q++   L+       
Sbjct: 1054 EKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQD------ 1107

Query: 420  SKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYN 479
                         IQK ++ ++  K LV EKS    KL++ EE   +C +E  K I+K N
Sbjct: 1108 -------------IQKEKSLKE--KELVNEKS----KLAEIEEI--KCRQE--KEITKLN 1144

Query: 480  VLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKT 539
                 +K    K I    + +Q++  + Q    + K  S  A V  E     I  + +K 
Sbjct: 1145 EELKSHKLESIKEITNLKDAKQLL--IQQKLELQGKADSLKAAVEQEKRNQQILKDQVKK 1202

Query: 540  NILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIET 599
                   E+E L+K   + +++++ L +E+KE ++ + + +E E     +   L + + T
Sbjct: 1203 -------EEEELKK---EFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGT 1252

Query: 600  VKDEKLNLETTLQESTAARQIMEREIENIQ-TYQSTAEEN--FLQEIKNAKSEASIYKNS 656
            VK E  + +  + E       +  EI  ++ T Q+  +E    L+     + E    +  
Sbjct: 1253 VKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTK 1312

Query: 657  LSEIGKECEMLSKMVMETKTDNQILKEELKKHSQ 690
            + E+ ++ +  +  V E   +NQ L+    KH+Q
Sbjct: 1313 VLELQRKLDNTTAAVQELGRENQSLQ---IKHTQ 1343



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 74/355 (20%), Positives = 156/355 (43%), Gaps = 25/355 (7%)

Query: 390 KIQYLQNYLKESVQIQKKVM-ELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVE 448
           ++Q LQ  LKE     +++  ELE      + + KP    T S  + +++ E+QL+    
Sbjct: 91  EVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAE-LQSLEQQLEEAQT 149

Query: 449 EKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQ 508
           E   I+      E+ + +   E   I SKY+  +   +  E+K  +L+ E  +    +  
Sbjct: 150 ENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQD 209

Query: 509 LKSK--EHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLG 566
           LK++  +     D+A++  E     ++++ +  N+ L +      E+++ +L  E   L 
Sbjct: 210 LKTELLQRPGIEDVAVLKKE----LVQVQTLMDNMTLER------ERESEKLKDECKKLQ 259

Query: 567 NELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIE 626
           ++   S+  I QL+ +  LAK  QE  + + E  K +    E T +  T    ++++E  
Sbjct: 260 SQYASSEATISQLRSE--LAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKE-- 315

Query: 627 NIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELK 686
             Q Y    E++  + +     +A++++  L     +C+ L   +  ++T    +  EL 
Sbjct: 316 --QDYTKLEEKHNEESVSKKNIQATLHQKDL-----DCQQLQSRLSASETSLHRIHVELS 368

Query: 687 KHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKI 741
           +  +   K +  +S +      L+   + ++ +R+  E     LQ E   L  K+
Sbjct: 369 EKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKL 423



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 142/770 (18%), Positives = 313/770 (40%), Gaps = 103/770 (13%)

Query: 59  LQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKT----LHSVEEKLSGDSV 114
           L+++LE +Q L+ Q  +   + T++  E  S+E+    E+++T    +  +++     + 
Sbjct: 109 LKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQ--QLEEAQTENFNIKQMKDLFEQKAA 166

Query: 115 NSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNV 174
               +  ++ S+   E   +LR + +   + +    ++ + ++++        P      
Sbjct: 167 QLATEIADIKSKYDEE--RSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVA 224

Query: 175 MSQADTVILDKSKITVPFLKHGFCENLDDICH-----------SIKQMKEELQKSHDGEV 223
           + + + V +      +   +    E L D C            +I Q++ EL K      
Sbjct: 225 VLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVA 284

Query: 224 ALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEE----NLDGNLNEDIKSK------ 273
               ELQ L++  +        ++       N +K+E     L+   NE+  SK      
Sbjct: 285 VYVQELQKLKSSVNELTQKNQTLTE------NLLKKEQDYTKLEEKHNEESVSKKNIQAT 338

Query: 274 ---RISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKN 330
              +  + + L  +L     ++ + HV    K +   K +    +  E   + +    K 
Sbjct: 339 LHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEV-ETKYQHLKAEFKQ 397

Query: 331 ITDLKFHSRVPRYTL-SFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVA 389
           +   +         L S ++Q   ++ + ERQ      G +  + + +S+     EQ VA
Sbjct: 398 LQQQREEKEQHGLQLQSEINQLHSKLLETERQ-LGEAHGRLKEQRQLSSEKLMDKEQQVA 456

Query: 390 ----KIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKN 445
               K+  L+  LKE V    ++     +      + + L  +T + +++ +   +Q+  
Sbjct: 457 DLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLR 516

Query: 446 LVEEK----STIQSKLSKTEEYSKECLKEFKKIISK----------YNVLQGQNKTLEEK 491
            + +K      +++ L K++E      KE + + +K           N LQ +N TL+E+
Sbjct: 517 QIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQ 576

Query: 492 NIQLS--LEKQ-------------QMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEA 536
             QL+  L+ Q             Q+ E    L++ + +  S    VN  N++++   E 
Sbjct: 577 VTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEK 636

Query: 537 MKTNILLIQDEKEML----EKKTHQ---LLKEKSSLGNELKESQLEI----IQLKEKERL 585
           +    + I+ + E+L      KT Q   L     +  N L++ Q E+     QL +    
Sbjct: 637 VSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAK 696

Query: 586 AKTEQETLLQI---IETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQE 642
            + +QE   Q+   ++  K++ L+LE   +E     QI + E ++++     ++E  LQ+
Sbjct: 697 LQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEG--QIKKLEADSLEV--KASKEQALQD 752

Query: 643 IKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQ-------ILKEELKKHSQENIKF 695
           ++  +   +  +   +E+ K+ EM  ++V  T+ D Q        +K++L K  +E    
Sbjct: 753 LQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQIL 812

Query: 696 ENSISRLTEDKIL----LENYVRSIENERDTLEFEMRHLQREYLSLSDKI 741
           +     L+++  +    L N +++   E   ++ E   L  E  ++ DK+
Sbjct: 813 KQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKL 862


>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
            [Homo sapiens]
          Length = 1388

 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 118/591 (19%), Positives = 255/591 (43%), Gaps = 94/591 (15%)

Query: 199  ENLDDICHSIKQMKEELQKSHDGEVALTNELQT----LQTDPDV--HRNGKYDMSPIHQD 252
            E L+  C S+    E+  K  + E+ L   +++    L+ +  +  H+N +Y     H+ 
Sbjct: 464  EELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEA 523

Query: 253  KMNFIKEENLDGNLN------EDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKL 306
                 K+ NL+ ++N      ED+K KR    +   +K+   +  + + +         L
Sbjct: 524  D----KKRNLENDVNSLKDQLEDLK-KRNQNSQISTEKVNQLQRQLDETNA--------L 570

Query: 307  SKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVK 366
             ++E     +  K   E   + K I  L+ ++R  +     L+  K +++ +    F+  
Sbjct: 571  LRTESDTAARLRKTQAE---SSKQIQQLESNNRDLQDKNCLLETAKLKLEKE----FINL 623

Query: 367  QGSIISENEKTSKVNSVTEQCVAKIQYLQNYLK-----------ESVQIQKKVMELESEN 415
            Q ++ SE    +  + +      +I  L+  LK           E  Q+Q++  +LE E 
Sbjct: 624  QSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEK 683

Query: 416  LNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKII 475
             N++  M   +   Q  +++ E   K  K  + +K+ I   +   EE   E +KE +K +
Sbjct: 684  SNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESI---EEAKSEAMKEMEKKL 740

Query: 476  SKYNVLQGQ--------------------------NKTLEEKNIQLSLEKQQMMEALDQL 509
             +   L+ +                          N+ L++K++ L+ + + +   ++Q 
Sbjct: 741  LEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDV-LNEDVRNLTLKIEQE 799

Query: 510  KSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNEL 569
              K   TQ+D+ +   + N + +  + +K     + + K  LEK+  +L KE+     ++
Sbjct: 800  TQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQM 859

Query: 570  KESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQ 629
            KE Q ++    E E+   T  +T ++ ++   +EK  L   LQ+        ++E+++ +
Sbjct: 860  KELQDQL----EAEQYFSTLYKTQVRELKEECEEKTKLGKELQQK-------KQELQDER 908

Query: 630  TYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHS 689
               +   E  L +  + +   SI +   S++ KE     K++ E +     +KE + +H 
Sbjct: 909  DSLAAQLEITLTKADSEQLARSIAEEQYSDLEKE-----KIMKELE-----IKEMMARHK 958

Query: 690  QENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDK 740
            QE  + + +I+ L E    L + V ++ NE++ L  +++ +Q +   L D+
Sbjct: 959  QELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDE 1009



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 148/770 (19%), Positives = 309/770 (40%), Gaps = 124/770 (16%)

Query: 5    KQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIA----------ESENQIQPQS 54
            +++ E  E+   L +  + L++    KE    + E  C +          E E +I  + 
Sbjct: 437  RKNEESQEIQKKLYTLEEHLSNEMQAKE----ELEQKCKSVNTRLEKTAKELEEEITLRK 492

Query: 55   ALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSV 114
            +++   +QLE  +AL    LQ+ +   + + ++ + +K +   D  +L    E L   + 
Sbjct: 493  SVESALRQLEREKAL----LQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQ 548

Query: 115  NSL--PQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPP 172
            NS    + VN   +   E    LRT +D  ++ +    +E+S  ++   +  R L     
Sbjct: 549  NSQISTEKVNQLQRQLDETNALLRTESDT-AARLRKTQAESSKQIQQLESNNRDLQDK-- 605

Query: 173  NVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTL 232
            N + +   + L+K  I           NL     S     E   ++H  E+    + +  
Sbjct: 606  NCLLETAKLKLEKEFI-----------NLQSALES-----ERRDRTHGSEIINDLQGRIC 649

Query: 233  QTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETV 292
              + D+ +NGK  ++ +  +K        L     +  K K   E++   +  +  +   
Sbjct: 650  GLEEDL-KNGKILLAKVELEK------RQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLE 702

Query: 293  SKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTL------S 346
             +   H   K +   K++++   +  K+     +  K + +     +V    L      S
Sbjct: 703  QEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCS 762

Query: 347  FLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQ--- 403
             LD    + + K  +  L+KQ  ++  NE    +    EQ   K    QN LK   Q   
Sbjct: 763  LLDCDLKQSQQKINE--LLKQKDVL--NEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVN 818

Query: 404  -IQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQ--SKLSKT 460
             ++    +L+ EN +L      L      L ++ +  + Q+K L ++    Q  S L KT
Sbjct: 819  TLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKT 878

Query: 461  E--EYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQS 518
            +  E  +EC ++ K             K L++K  +L  E+  +   L+   +K    Q 
Sbjct: 879  QVRELKEECEEKTKL-----------GKELQQKKQELQDERDSLAAQLEITLTKADSEQL 927

Query: 519  DMAIVNNENNRMSIE--MEAMKTNILLIQDEKEMLEKKTH----------------QLLK 560
              +I   + + +  E  M+ ++   ++ + ++E+ EK                    L  
Sbjct: 928  ARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLAN 987

Query: 561  EKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQI 620
            EK  L N+LK+ Q ++ +LK++E  A          I+   +++L  E TL+        
Sbjct: 988  EKEELNNKLKDVQEQLSRLKDEEISAAA--------IKAQFEKQLLTERTLK-------- 1031

Query: 621  MEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQI 680
                         T   N L EI N K    + + + +++ ++ +   K+ ME K++ + 
Sbjct: 1032 -------------TQAVNKLAEIMNRKE--PVKRGNDTDVRRKEKENRKLHMELKSEREK 1076

Query: 681  LKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHL 730
            L +++ K+ +E  + +  I+  ++ +I L+  + S +++ + L  +++ L
Sbjct: 1077 LTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQAL 1126



 Score = 31.2 bits (69), Expect = 4.0
 Identities = 28/115 (24%), Positives = 52/115 (45%), Gaps = 4/115 (3%)

Query: 637 ENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQE-NIKF 695
           EN L     +  E    ++  +E  +E +     + E  ++    KEEL++  +  N + 
Sbjct: 418 ENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRL 477

Query: 696 ENSISRLTEDKIL---LENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHND 747
           E +   L E+  L   +E+ +R +E E+  L+ +    QR+    +DK  N  ND
Sbjct: 478 EKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLEND 532


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 140/654 (21%), Positives = 268/654 (40%), Gaps = 88/654 (13%)

Query: 109  LSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLP 168
            L   S++S  +S+ +  +  +ED   L    ++L S+ I   +E  +  K     Y  L 
Sbjct: 1560 LENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILL 1619

Query: 169  TAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNE 228
             +  NV ++A                    E +  +  +++Q K+EL     G++  T E
Sbjct: 1620 QSYENVSNEA--------------------ERIQHVVEAVRQEKQELY----GKLRST-E 1654

Query: 229  LQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPF 288
                +T+  + +  + +M  + +    F K            K ++I ELE    +L   
Sbjct: 1655 ANKKETEKQL-QEAEQEMEEMKEKMRKFAKS-----------KQQKILELEEENDRL--- 1699

Query: 289  RETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFL 348
                 +  VH      K     +     + K   E           KF S      +S  
Sbjct: 1700 -----RAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQS-----LMSEK 1749

Query: 349  DQTKHEMKDKERQ-PFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKK 407
            D    E++D + Q    V + + +   EK     +VTE+     Q +    +E   +   
Sbjct: 1750 DSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGT---QSIPGETEEQDSLSMS 1806

Query: 408  VMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKEC 467
                 SE++       P +    S   ++  Y +Q+  L E  + ++ +  K +E+S+  
Sbjct: 1807 TRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTL 1866

Query: 468  LKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQL-----KSKEHKTQSDMAI 522
              E   ++S+ +   G+ K L+E+  +++L  QQ+ E L ++      ++E K   +  +
Sbjct: 1867 ENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERL 1926

Query: 523  VN-------NENNRMSIEMEAMKTNILLIQDEKEM------LEKKTHQLLKEKSSLGNEL 569
            +N       +  N      +A   N LL  + K +      LE++  QL+KEK+ + +E+
Sbjct: 1927 MNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEI 1986

Query: 570  KESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLE---TTLQESTAARQIMEREIE 626
            ++  LE IQ  +KE   K+  + L ++++  + E   L+      QE  +A +   + +E
Sbjct: 1987 RKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALE 2046

Query: 627  NIQTYQ----STAEENFLQEI---KNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQ 679
             +QT         +EN  Q +   K A++E + +K  L +   E   +    ++ K + Q
Sbjct: 2047 FVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQ 2106

Query: 680  ILKEELKKHSQENIKFENSISRL--TEDKILLENYVRSIENERDTLEFEMRHLQ 731
              KE +K  SQ   K E+   RL   E+K L E   ++++ + D L  E  HL+
Sbjct: 2107 SNKESVK--SQMKQKDEDLERRLEQAEEKHLKEK--KNMQEKLDALRREKVHLE 2156



 Score = 83.2 bits (204), Expect = 9e-16
 Identities = 140/714 (19%), Positives = 280/714 (39%), Gaps = 88/714 (12%)

Query: 71   MQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSV--NVPSQIH 128
            M+TL + +   + + E + ME     +  ++L S ++ LS + V  L   +  NV  Q +
Sbjct: 1714 METLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLS-EEVQDLKHQIEGNVSKQAN 1772

Query: 129  SEDTLTL--RTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKS 186
             E T     +T+     +  I   +E  D L          PT   +V S          
Sbjct: 1773 LEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTR-----PTCSESVPSAKSA----NP 1823

Query: 187  KITVPFLKH----GFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNG 242
             ++  F  H     + + +D +   I  ++EE QK+ +    L NE  TL +     ++G
Sbjct: 1824 AVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQIST-KDG 1882

Query: 243  KYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEA------LVKKLLPFRETVSKFH 296
            +  M      KMN + ++ +   L+   K K  +E E       L+ +L     ++  + 
Sbjct: 1883 ELKMLQEEVTKMNLLNQQ-IQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNY- 1940

Query: 297  VHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMK 356
                  C+ ++ +++    KNE    E+    K +++L+   +        L + K +++
Sbjct: 1941 ------CQDVTDAQI----KNELLESEMKNLKKCVSELEEEKQQ-------LVKEKTKVE 1983

Query: 357  DKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENL 416
             + R+ +L K      E    S    + E    K Q ++   K+ ++ Q+K+  LE    
Sbjct: 1984 SEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVK 2043

Query: 417  NLK----SKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFK 472
             L+       K L  T ++L Q VE  +K    L   K  +    S+      + LK  K
Sbjct: 2044 ALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKK 2103

Query: 473  KIISKYNVLQGQNKT-----------LEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMA 521
            ++ S    ++ Q K             EEK+++   EK+ M E LD L+ ++   +  + 
Sbjct: 2104 ELQSNKESVKSQMKQKDEDLERRLEQAEEKHLK---EKKNMQEKLDALRREKVHLEETIG 2160

Query: 522  IVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEI---IQ 578
             +    N+   E++ ++ N+     +     K    L  ++  + +E K+ + +    IQ
Sbjct: 2161 EIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQ 2220

Query: 579  LKEKERLAKTE-----QETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQS 633
             KE+E   K +     ++ L Q+   +++ K+N+     +        + E++  Q    
Sbjct: 2221 SKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCD 2280

Query: 634  TAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENI 693
            T +    + +   +    +Y +S +E+ K                  L+ ELK    +  
Sbjct: 2281 TLQGENKELLSQLEETRHLYHSSQNELAK------------------LESELKSLKDQLT 2322

Query: 694  KFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHND 747
               NS+ +  E K  LE  +R  E +    +F    L+ +  +  +     H +
Sbjct: 2323 DLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEE 2376



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 167/867 (19%), Positives = 353/867 (40%), Gaps = 173/867 (19%)

Query: 27   SEGVKESGCSDTE-YGCIAESENQIQPQSALKVLQQQL---ESFQALRMQTLQNVSMPTE 82
            SE    S C + E Y     SE +++ Q   K L+++L   E FQAL  Q  Q +   T 
Sbjct: 1047 SEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKT- 1105

Query: 83   NQEENLSMEKSHHFED-SKTLHSVEEKLSGDSVNSLPQSVNVP-----SQIH-----SED 131
            NQ + L  E S +     K + S  +   GDSV  + ++V +      S  H      E 
Sbjct: 1106 NQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEK 1165

Query: 132  TLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVP 191
             L L    + L   +    +    ILK      R L      +  Q D    D +++   
Sbjct: 1166 ILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLRE---ELKQQKD----DYNRLQEQ 1218

Query: 192  FLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHR-----NGKYDM 246
            F +    +  ++I   ++Q++ ++++S DG++  T++ ++  + P +         ++  
Sbjct: 1219 FDEQS--KENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHT 1276

Query: 247  SPI-----------HQDKMNFIKEENLDGNLNEDIK-------------SKRISELEALV 282
             P+           H +  + ++       +   +K             S   SEL    
Sbjct: 1277 QPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKS 1336

Query: 283  KKLLPFRETVSK--------------FHVHFCRKCKKLSKSEM------HRGKKNEKNNK 322
            +++   +E ++K                VH     +KL  S++      H  +   K ++
Sbjct: 1337 EEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDE 1396

Query: 323  EIPITGKNITDLKFHS--------RVPRYTLSFLDQ--------TKHEMKDKERQPFLVK 366
               +  K   D+ + S         + +     ++Q        T+ EM+ KE     +K
Sbjct: 1397 LQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDE-RIK 1455

Query: 367  QGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLI 426
            Q  +    E   K   + E+  AK Q +Q  L+ ++  +K+ ++   EN +L+ ++    
Sbjct: 1456 QLQV-ELCEMKQKPEEIGEESRAK-QQIQRKLQAALISRKEALK---ENKSLQEELSLAR 1510

Query: 427  FTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNK 486
             T + L + +   E Q+    +EK T+  +L+  +E   + + E  + + +   L    +
Sbjct: 1511 GTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCE 1570

Query: 487  TLEEKNIQLSLEKQQMMEALDQLKS-----------KEHKTQSDMAIVNNENNRMSIEME 535
            +L+     L+ +K+++++ ++ LKS           K  + Q +  I+      +S E E
Sbjct: 1571 SLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAE 1630

Query: 536  AMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKER-LAKTEQETLL 594
             ++  +  ++ EK+ L  K       K     +L+E++ E+ ++KEK R  AK++Q+ +L
Sbjct: 1631 RIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKIL 1690

Query: 595  QIIETVKDEKLN-------------LETTLQESTAARQIMER---EIENI-QTYQS--TA 635
            ++ E  ++++L              +ET L  + + ++ +ER   E E + + +QS  + 
Sbjct: 1691 ELEE--ENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSE 1748

Query: 636  EENFLQEIKNAK--------------------SEASIYKNSLSEIGKECEMLSKMVMET- 674
            +++  +E+++ K                    ++ ++ +     I  E E    + M T 
Sbjct: 1749 KDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTR 1808

Query: 675  ----------KTDNQILKEELKKHSQEN------IKFENSISRLTEDKILLENYVRSIEN 718
                      K+ N  + ++   H + N       + +  I+ L E+K   + + +++EN
Sbjct: 1809 PTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLEN 1868

Query: 719  ERDTL-------EFEMRHLQREYLSLS 738
            E++TL       + E++ LQ E   ++
Sbjct: 1869 EKNTLLSQISTKDGELKMLQEEVTKMN 1895



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 167/848 (19%), Positives = 337/848 (39%), Gaps = 151/848 (17%)

Query: 4    EKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQQL 63
            E    E+D+++  L++    LN S G   + C D      A+ +N++  +S +K L++ +
Sbjct: 1913 ETAEEEKDDLEERLMNQLAELNGSIG---NYCQDVTD---AQIKNELL-ESEMKNLKKCV 1965

Query: 64   ESFQALRMQTL-QNVSMPTENQEENLSM---------EKSHHFEDSKTLHSVEEKLSG-- 111
               +  + Q + +   + +E ++E L            KSH  E  + L   ++++    
Sbjct: 1966 SELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQ 2025

Query: 112  -------DSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFY 164
                   + +++L ++V     + +E    L  + +NL+  +       +++        
Sbjct: 2026 KDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELAS------ 2079

Query: 165  RFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHD---- 220
                    +  S+A  V+ D  K     LK     N + +   +KQ  E+L++  +    
Sbjct: 2080 --FKVLLDDTQSEAARVLADNLK-----LKKELQSNKESVKSQMKQKDEDLERRLEQAEE 2132

Query: 221  ---------------------------GEVALT-----NELQTLQTDPD--VHRNGKY-- 244
                                       GE+ +T      E+Q LQ + D  V +   +  
Sbjct: 2133 KHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTK 2192

Query: 245  DMSPIHQDKMNFIKE-ENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKC 303
             MS +  D+   I E +  +   ++ I+SK   E+          ++ + +  +H     
Sbjct: 2193 SMSSLQDDRDRVIDEAKKWERKFSDAIQSKE-EEIRLKEDNCSVLKDQLRQMSIHMEELK 2251

Query: 304  KKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKH-------EMK 356
              +S+ E  +     K   E+ +  K    L+  ++     LS L++T+H       E+ 
Sbjct: 2252 INISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKE---LLSQLEETRHLYHSSQNELA 2308

Query: 357  DKERQPFLVKQ------GSIISENEKTSKVNSVTEQCVAKIQ---YLQNYLKESVQIQKK 407
              E +   +K        S+    E+   +  +  Q  A IQ   +    L+  +Q  ++
Sbjct: 2309 KLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRE 2368

Query: 408  VMELESENLNLKS-KMKPLIFTTQSLIQKV-----ETYEKQLKNLVEEKSTIQSKLSKTE 461
            +     E +N+K  K+  L+   +  IQ       + ++K++K L       ++ LS+ E
Sbjct: 2369 LTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKEL-------ENLLSQEE 2421

Query: 462  EYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMA 521
            E +    +E KK + K N L    KT++++NIQ   +    ++++  L++   +   D  
Sbjct: 2422 EENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQ 2481

Query: 522  IVNNENNRMSIEMEAMKTNILLIQD---EKEMLEKKTHQLLKEKSSLGNELKESQLEIIQ 578
             +  E   +SI +E  +    LIQ+   E   L+++   L      L +E  +   E+IQ
Sbjct: 2482 QL--EERHLSIILEKDQ----LIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQ 2535

Query: 579  LKE--------KERLAKTEQETLLQIIETVKDEKLNLETTLQESTAA------------- 617
             +E        K+   K   E  LQ  + ++++   LE  L+ES  A             
Sbjct: 2536 YREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQE 2595

Query: 618  -RQIMEREIENIQT--YQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMET 674
             +Q + +EIE+++    Q T +   LQE    +    +Y   L    +E   LS +   +
Sbjct: 2596 EKQDLSKEIESLKVSISQLTRQVTALQE----EGTLGLYHAQLKVKEEEVHRLSALFSSS 2651

Query: 675  KTDNQILKEELKKHSQENIKFENSI-SRLTEDKILLENYVRSIENERDTLEFEMRHLQRE 733
            +     L+EEL    +E  K    I  +L ++   L +    + NE +T E  +  L R+
Sbjct: 2652 QKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARD 2711

Query: 734  YLSLSDKI 741
             + +  K+
Sbjct: 2712 LVEMEQKL 2719



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 116/614 (18%), Positives = 256/614 (41%), Gaps = 84/614 (13%)

Query: 199  ENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIK 258
            + L D+ +S+++ KE+ + + +G +         Q + D+ +N K+    +  D      
Sbjct: 2319 DQLTDLSNSLEKCKEQ-KGNLEGIIR--------QQEADI-QNSKFSYEQLETDLQ---A 2365

Query: 259  EENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKN- 317
               L   L+E+I  K    +  L  K    +  +++      ++ K+L        ++N 
Sbjct: 2366 SRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENI 2425

Query: 318  ---EKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISEN 374
               E+N K +  T + +  LK   +      + LD     M   +     +  G      
Sbjct: 2426 VLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIV-GDYQQLE 2484

Query: 375  EKTSKVNSVTEQCVAKIQYLQNYLKESVQ-IQKKVMELESENLNLKSKMKPLIFTTQSLI 433
            E+   +    +Q + +     N LKE ++ ++  + +L SEN  L ++   LI   + L 
Sbjct: 2485 ERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAE---LIQYREDLN 2541

Query: 434  QKVETYEKQLKNLVE----EKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLE 489
            Q +   + Q K L+E    +   +++K +K EE  KE  +  + +   +N LQ + + L 
Sbjct: 2542 QVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLS 2601

Query: 490  EKNIQLSLEKQQMMEALD-------------QLKSKEHKTQSDMAIVNNENNRMS----- 531
            ++   L +   Q+   +              QLK KE +     A+ ++   R++     
Sbjct: 2602 KEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEE 2661

Query: 532  ---IEMEAMKT-----------------NILLIQDEKEMLEKKTHQLLKEKSSLGNEL-- 569
               ++ EA K                  +  ++++E E  E++  +L ++   +  +L  
Sbjct: 2662 LVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLM 2721

Query: 570  --KESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQ--IMEREI 625
              KE++    Q++   R   + Q +     E + + K   + +L+E    ++  ++ RE 
Sbjct: 2722 VTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRER 2781

Query: 626  ENIQTY----QSTAEENFLQEIKN------AKSEASIYKNS-LSEIGKECEMLSKMVMET 674
            + + +      ++ EEN L  ++       +K E  ++ +S L +   + +  SK +   
Sbjct: 2782 DALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASL 2841

Query: 675  KTDNQILKEELKKHSQENIKFENSISRLTEDKI---LLENYVRSIENERDTLEFEMRHLQ 731
            + +   L  EL+K  +     + S ++ +        L+  + S++N+RD L  E+++LQ
Sbjct: 2842 QNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQ 2901

Query: 732  REYLSLSDKICNQH 745
            ++YL ++ +I   H
Sbjct: 2902 QQYLQINQEITELH 2915



 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 114/584 (19%), Positives = 241/584 (41%), Gaps = 59/584 (10%)

Query: 226 TNELQTLQTDPDVHRNGKYDMSPIHQDKMN--FIKEENLDGNLNEDIKSKRIS---ELEA 280
           T++      DP++H+    + +   Q+ +       E L   L + I+ K +    + EA
Sbjct: 22  TDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEA 81

Query: 281 LVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRV 340
           L ++       + K  +H   K   L+K   +  +   +    +P   ++   L  H + 
Sbjct: 82  LQEERKAADNKIKKLKLHAKAKLTSLNK---YIEEMKAQGGTVLPTEPQSEEQLSKHDKS 138

Query: 341 PRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKE 400
                  +++ KH++++KE     ++     ++ E+ ++ ++  E+ V   Q LQ   + 
Sbjct: 139 STEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEF 198

Query: 401 SVQIQKKVMELESENLNLK-SKMKPLIFTTQ--------------------------SLI 433
              +Q ++ + ++E    +  + K   F TQ                           L 
Sbjct: 199 ISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQ 258

Query: 434 QKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNI 493
           +K+E +E+ L    +    +Q +L+  E+ ++   ++ +++ +++N L+   +T E +  
Sbjct: 259 RKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVET-EREES 317

Query: 494 QLSLEKQQMMEALDQLKSKEHKTQSDM-AIVNNENNRMSIEMEAMKTNILLIQDEKEMLE 552
           ++ LEK ++  A  + K   H  Q +M  ++         + E       L Q  K  +E
Sbjct: 318 KILLEKMELEVA--ERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEME 375

Query: 553 KKTHQLL------KEKSSLGNELKESQLEIIQLKEKERL--AKTEQETLLQIIETVKD-- 602
           +KT  +L      +E  S  + LK+   +++Q K ++ +  A+T Q+   Q+ +  K+  
Sbjct: 376 EKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEIS 435

Query: 603 EKLNLETTLQESTAARQIMEREIENIQTYQSTAEENF------LQEIKNAKSEASIYKNS 656
           + LN    LQ+   A Q    ++ N  T Q+  EEN       + E++N K    +    
Sbjct: 436 QFLN-RLPLQQHETASQTSFPDVYNEGT-QAVTEENIASLQKRVVELENEKGALLLSSIE 493

Query: 657 LSEIGKECEMLSKMVMETKTDNQI--LKEELKKHSQENIKFENSISRLTEDKILLENYVR 714
           L E+  E E LS  +   +  N+      E+ + S  +I  + S S     + +LEN   
Sbjct: 494 LEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFS 553

Query: 715 SIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRRE 758
               E   L  EM+  Q E   L  ++  +  + +    + ++E
Sbjct: 554 QKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKE 597



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 131/634 (20%), Positives = 246/634 (38%), Gaps = 122/634 (19%)

Query: 208  IKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQ-------DKMNFIKEE 260
            IK +KE+L      E A   +++         +    +MSP  Q        + + +K+E
Sbjct: 928  IKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKE 987

Query: 261  NLDGN-------LNEDIKSKRISELEALV-------KKLLPFRETV------SKFHVHFC 300
            N           +N     +R+S LE  +       KK +P  ET        K +  + 
Sbjct: 988  NEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYS 1047

Query: 301  RKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKER 360
             KC      E+    K   + KE+ +      DL+          + + Q    ++DK  
Sbjct: 1048 EKCVTSKCQEIEIYLKQTISEKEVELQHIR-KDLEEKLAAEEQFQALVKQMNQTLQDKTN 1106

Query: 361  QPFLVKQGSIISENEK------TSKVNSVTEQCVAKIQYLQNYLKESV------------ 402
            Q  L++  + ISEN+       TS  ++     VA +       KE+V            
Sbjct: 1107 QIDLLQ--AEISENQAIIQKLITSNTDASDGDSVALV-------KETVVISPPCTGSSEH 1157

Query: 403  ---QIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSK 459
               ++++K++ LE E   L+ K++  + + +++++K +  E+ L+   EE    +   ++
Sbjct: 1158 WKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLR---EELKQQKDDYNR 1214

Query: 460  TEEYSKECLKEFKKIISKYNVLQGQN----------------------------KTLEEK 491
             +E   E  KE + I  +   LQ Q                             K  E+ 
Sbjct: 1215 LQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQH 1274

Query: 492  NIQLSLEKQ----------------------QMMEALDQLKSKEHKTQSDMAIVNNENNR 529
            + Q  LE                        Q+   L ++++++ + +  ++   +E  +
Sbjct: 1275 HTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTK 1334

Query: 530  MSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTE 589
             S E+  ++  I     E E L+  +H+      SL  +L+ SQL+I  L+    L + +
Sbjct: 1335 KSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLREL-QPK 1393

Query: 590  QETLLQIIETVKDEKLNLETTLQESTAA-----RQIMERE--IENIQTYQSTAEENFLQE 642
             + L ++I   +++   L   L E  AA      +I+E+E  I+ + T      +   + 
Sbjct: 1394 LDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDER 1453

Query: 643  IKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELK--KHSQENIKF-ENSI 699
            IK  + E    K    EIG+E     ++  + +      KE LK  K  QE +     +I
Sbjct: 1454 IKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTI 1513

Query: 700  SRLTEDKILLENYVRSIENERDTLEFEMRHLQRE 733
             RLT+    +E+ V +   E+DT+   +  LQ E
Sbjct: 1514 ERLTKSLADVESQVSAQNKEKDTVLGRLALLQEE 1547



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 143/787 (18%), Positives = 312/787 (39%), Gaps = 108/787 (13%)

Query: 44   AESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHH--FEDSKT 101
            AE  NQI        L QQL+  +A    TL+N ++ TE +E  + +EK      E   +
Sbjct: 285  AEQRNQI--------LSQQLQQMEA-EHNTLRN-TVETEREESKILLEKMELEVAERKLS 334

Query: 102  LHSVEEKL---------SGDSVNSLPQSVNVPSQIHSEDT-------LTLRTSTDNLSSN 145
             H+++E++         +G +   L    +   Q H  +        L+L+ +   L S 
Sbjct: 335  FHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSA 394

Query: 146  IIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKH--------GF 197
                  +NS +L++ N             + Q +  +  KSK    FL            
Sbjct: 395  CDALKDQNSKLLQDKNE----QAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETAS 450

Query: 198  CENLDDICHSIKQM--KEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMN 255
              +  D+ +   Q   +E +       V L NE   L          K +   +   ++ 
Sbjct: 451  QTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKL-SSQIT 509

Query: 256  FIKEENLDGNLNE--------DIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLS 307
             ++ +N  G  +         DI +KR S  E   + +L    T S+ H        ++ 
Sbjct: 510  LLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVL--ENTFSQKHKELSVLLLEMK 567

Query: 308  KSEMH--------RGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEM---- 355
            +++          +GK+ E+ + E+ +  K +  ++     P     FL+ T  +     
Sbjct: 568  EAQEEIAFLKLQLQGKRAEEADHEV-LDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMP 626

Query: 356  KDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESEN 415
             ++   P + K+ +      +TS+  S+ +  V     L++  ++  +    V ++   +
Sbjct: 627  NEESSLPAVEKEQASTEHQSRTSEEISLNDAGVE----LKSTKQDGDKSLSAVPDIGQCH 682

Query: 416  LNLKSKMKPLIFTTQSLIQKV-ETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKI 474
             +   ++K  I   +    K  E YEK L    +E S +   + + ++ +      F  +
Sbjct: 683  QDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTAL 742

Query: 475  ISKYNVLQGQNKTL--------EEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNE 526
              + + L  Q K L        + K ++++L + +    LD      H       ++  +
Sbjct: 743  SEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDN-----LLTEQ 797

Query: 527  NNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLA 586
             + +SIE ++    I ++Q+E + ++ +  +      SL ++L+  + E+++  E+ R  
Sbjct: 798  IHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHI 857

Query: 587  KTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQ--EIK 644
             ++ E L Q +      +  LE T  +     Q++  +  +++T Q T EE   Q  EI 
Sbjct: 858  SSKVEELSQAL-----SQKELEITKMD-----QLLLEKKRDVETLQQTIEEKDQQVTEIS 907

Query: 645  NAKSEASIYKNSLS-EIGKECEMLSKMVMETKTDNQILKEELKKHSQ------ENIKFEN 697
             + +E  +  N     +G E + L + +       +  KE++++ ++      +N    +
Sbjct: 908  FSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMS 967

Query: 698  SISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYL-----SLSDKICNQHNDPSKTT 752
               +++++++  E  +   ENE+   + +   + R+ L      L +++ N  ++  K  
Sbjct: 968  PAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEI 1027

Query: 753  YISRREK 759
             +S  E+
Sbjct: 1028 PLSETER 1034



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 116/546 (21%), Positives = 218/546 (39%), Gaps = 125/546 (22%)

Query: 209  KQMKEELQKSHDGEVALTN---ELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGN 265
            +Q   E Q     E++L +   EL++ + D D   +   D+   HQD++  +K + L+  
Sbjct: 638  EQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELE 697

Query: 266  LNEDIKSKRISE--LEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKE 323
            LN   K++ I E  L+   K++    + + +F                   KKN  NN  
Sbjct: 698  LNFH-KAQEIYEKNLDEKAKEISNLNQLIEEF-------------------KKNADNNSS 737

Query: 324  IPITGKNITDLKFHSRVPRYTL-----SFLDQTKHEMKDKERQPFLVKQGSIISENEKTS 378
               T  +    +  S+V   ++     + + Q +  + + ERQ  L  +     +N  T 
Sbjct: 738  A-FTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTE 796

Query: 379  KVNSVTEQCVAK---IQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQK 435
            +++S++ +  +K   I+ LQN L + VQ+Q              S+   LI + QS +Q 
Sbjct: 797  QIHSLSIEAKSKDVKIEVLQNEL-DDVQLQF-------------SEQSTLIRSLQSQLQN 842

Query: 436  VETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQL 495
             E+       ++E    ++   SK EE S + L + +  I+K +              QL
Sbjct: 843  KES------EVLEGAERVRHISSKVEELS-QALSQKELEITKMD--------------QL 881

Query: 496  SLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKT 555
             LEK++ +E L Q   ++ +  ++++    E                           K 
Sbjct: 882  LLEKKRDVETLQQTIEEKDQQVTEISFSMTE---------------------------KM 914

Query: 556  HQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQEST 615
             QL +EK SLG E+K        LKE+  L    +E   + +E   +    L+    E +
Sbjct: 915  VQLNEEKFSLGVEIKT-------LKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMS 967

Query: 616  AARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETK 675
             A QI + E+++   +    +EN   E +  K +A++            E+L + V   +
Sbjct: 968  PAGQISKEELQH--EFDLLKKEN---EQRKRKLQAALINRK--------ELLQR-VSRLE 1013

Query: 676  TDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRS--------IENERDTLEFEM 727
             +   LK+E KK    +      +    E+K   E  V S        ++      E E+
Sbjct: 1014 EELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVEL 1073

Query: 728  RHLQRE 733
            +H++++
Sbjct: 1074 QHIRKD 1079



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 75/383 (19%), Positives = 161/383 (42%), Gaps = 62/383 (16%)

Query: 447 VEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNV--------LQGQNKTLEEKNIQLSLE 498
           +E  +T Q  + +   Y+++ + E K II + +V        LQ + K  + K  +L L 
Sbjct: 40  MEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLH 99

Query: 499 KQQMMEAL----DQLKSK-----EHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKE 549
            +  + +L    +++K++       + QS+  +  ++ +    EME  K    L Q+++E
Sbjct: 100 AKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKL-QEKEE 158

Query: 550 MLEKKTHQLLK----EKSSLGNELKESQLEIIQLKEKE--------RLAKTEQETLLQII 597
           ++     QL +    + +    E++E  +   QL+EKE        +L++T+ E   Q +
Sbjct: 159 LISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQV 218

Query: 598 ETVKDEKLNLETTLQESTAARQIMEREIEN-----IQTYQSTAEEN-------------F 639
              KD +   +  L E    + + + ++E      ++  Q   EE+              
Sbjct: 219 VREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLL 278

Query: 640 LQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELK-KHSQENIKFENS 698
            QE+  A+    I    L ++  E   L   V   + +++IL E+++ + ++  + F N 
Sbjct: 279 QQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNL 338

Query: 699 ISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRRE 758
              +     LLE + ++ + + +        L+  Y +L  K  ++     KT++I   +
Sbjct: 339 QEEMHH---LLEQFEQAGQAQAE--------LESRYSALEQK--HKAEMEEKTSHILSLQ 385

Query: 759 KFHFDNYTHEDTSSPQSRPLASD 781
           K   +  +  D    Q+  L  D
Sbjct: 386 KTGQELQSACDALKDQNSKLLQD 408



 Score = 36.2 bits (82), Expect = 0.12
 Identities = 97/546 (17%), Positives = 206/546 (37%), Gaps = 60/546 (10%)

Query: 43   IAESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTL 102
            I  +E +   +   ++ +  +E  Q L M T +N  +  + Q    SM    +  D    
Sbjct: 2693 IMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANE 2752

Query: 103  HSVEEKLSGD-SVNSLPQSVNVPSQIHSEDTLTLRT--STDNLSSNIIIHPSENSDILKN 159
               E K   D S+  L Q           D L   T  S ++   N + H  + +  L +
Sbjct: 2753 ELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLS 2812

Query: 160  YNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSH 219
             +     L +   +  +Q  +                F + +  + +    +  EL+K  
Sbjct: 2813 KDEQLLHLSSQLEDSYNQVQS----------------FSKAMASLQNERDHLWNELEKFR 2856

Query: 220  DGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIK--SKRISE 277
              E           T P   ++ K  MS +  D+   +KE     NL +     ++ I+E
Sbjct: 2857 KSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELK---NLQQQYLQINQEITE 2913

Query: 278  LEALVKKLLPFRETVSKFHV--HFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLK 335
            L  L  +L  +++    F +     R+     + E+H+  + EK++ EI           
Sbjct: 2914 LHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQ-LRMEKSSWEI----------- 2961

Query: 336  FHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQ 395
             H R  +      +Q    + DK++Q  L    ++I E   +S     ++    K+QY +
Sbjct: 2962 -HERRMK------EQYLMAISDKDQQ--LSHLQNLIRELRSSS-----SQTQPLKVQYQR 3007

Query: 396  NYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQS 455
                E+         L  E   L++++   +        +++        L+EEK+T+  
Sbjct: 3008 QASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSI 3067

Query: 456  KLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHK 515
            +L  T +  +E  + +  +++   VL+ Q + L+   + +      +     Q K+  H+
Sbjct: 3068 QLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNI-----DVAPGAPQEKNGVHR 3122

Query: 516  TQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLE 575
             +SD   +       S   + +      + + +++LE++  Q +  +++L   + E Q+ 
Sbjct: 3123 -KSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENAL--SVAEEQIR 3179

Query: 576  IIQLKE 581
             ++  E
Sbjct: 3180 RLEHSE 3185


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 95/411 (23%), Positives = 198/411 (48%), Gaps = 42/411 (10%)

Query: 348  LDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKK 407
            + + + EM  KE +   V++  + +EN  T ++ ++  Q +A+   LQ  L+   ++  +
Sbjct: 840  VSRQEEEMMAKEEELVKVREKQLAAENRLT-EMETLQSQLMAEKLQLQEQLQAETELCAE 898

Query: 408  VMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKEC 467
              EL +    L +K + L      L  +VE  E++ ++L  EK  +Q  + + EE  +E 
Sbjct: 899  AEELRAR---LTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEE 955

Query: 468  LKEFKKII-------SKYNVLQGQNKTLEEKNIQLSLEKQ----QMMEALDQLKSKEHKT 516
                +K+        +K   L+ +   LE++N +L+ EK+    ++ E    L  +E K+
Sbjct: 956  ESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKS 1015

Query: 517  QSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEI 576
            +S +A + N++  M  ++E     +   + +++ LEK   +L  + + L +++ E Q +I
Sbjct: 1016 KS-LAKLKNKHEAMITDLE---ERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQI 1071

Query: 577  IQLKEKERLAKTEQE---TLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQS 633
             +L  K +LAK E+E    L ++ E    + + L+  ++E  +    ++ ++E+ +  ++
Sbjct: 1072 AEL--KMQLAKKEEELQAALARVEEEAAQKNMALK-KIRELESQISELQEDLESERASRN 1128

Query: 634  TAEE---NFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELK---- 686
             AE+   +  +E++  K+E    +++L     + E+ SK   E     + L+EE K    
Sbjct: 1129 KAEKQKRDLGEELEALKTE---LEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEA 1185

Query: 687  -------KHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHL 730
                   KHSQ   +    + +    K  LE   +++ENER  L  E++ L
Sbjct: 1186 QIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVL 1236



 Score = 73.2 bits (178), Expect = 9e-13
 Identities = 119/590 (20%), Positives = 257/590 (43%), Gaps = 68/590 (11%)

Query: 199  ENLDDICHS----IKQMKEELQKSHDGEVALTNELQTL--QTDPDVHRNGKYDMSPIHQD 252
            + L++ICH     +++ +E  Q     +  +   +Q L  Q + +     K  +  +  +
Sbjct: 911  QELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTE 970

Query: 253  -KMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPF------RETVSKFHVHFCRKCKK 305
             K+  ++EE +   + ED   K   E + L  ++  F       E  SK       K + 
Sbjct: 971  AKLKKLEEEQI---ILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEA 1027

Query: 306  LSKSEMHRGKKNEKNNKEIPITGKNI----TDLKFHSRVPRYTLSFLDQTKHEMKDKERQ 361
            +      R ++ EK  +E+  T + +    TDL       +  ++ L + +   K++E Q
Sbjct: 1028 MITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAEL-KMQLAKKEEELQ 1086

Query: 362  PFLVK-QGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKS 420
              L + +     +N    K+  +  Q     + L++      + +K+  +L  E   LK+
Sbjct: 1087 AALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKT 1146

Query: 421  KMKPLIFTT---QSLIQKVETYEKQLKNLVEEKST--------IQSKLSKTEEYSKECLK 469
            +++  + +T   Q L  K E     LK  +EE++         ++ K S+  E   E L+
Sbjct: 1147 ELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLE 1206

Query: 470  EFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQS---DMAIVNNE 526
            + K++ +    L+   +TLE +  +L+ E + +++     + K  K ++   ++ +  NE
Sbjct: 1207 QTKRVKAN---LEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNE 1263

Query: 527  NNRMSIEMEAMKTNILLIQDEKEML----EKKTHQLLKEKSSLGNELKESQLEIIQLKEK 582
              R+  E+    T + +  D    L    + K+ +L K+ S+L ++L+++Q E++Q + +
Sbjct: 1264 GERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQ-ELLQEENR 1322

Query: 583  ERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENF--- 639
            ++L+ + +      ++ V+DEK +    L+E   A+  +E++I  +    +  ++     
Sbjct: 1323 QKLSLSTK------LKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDS 1376

Query: 640  ---LQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKT------DNQILKEELKKHSQ 690
               L+  +  K +       LS+  +E       + +TKT      D+ ++  + ++ S 
Sbjct: 1377 VGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSA 1436

Query: 691  ENI--KFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLS 738
             N+  K +     L E+K +   Y      ERD  E E R  + + LSL+
Sbjct: 1437 CNLEKKQKKFDQLLAEEKTISAKYA----EERDRAEAEAREKETKALSLA 1482



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 147/738 (19%), Positives = 298/738 (40%), Gaps = 94/738 (12%)

Query: 55   ALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSV 114
            A++ L +QLE  + ++   L+      EN+   L+ E     +         +K+    +
Sbjct: 1197 AVEELAEQLEQTKRVKAN-LEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQ-L 1254

Query: 115  NSLPQSVNVPSQIHSE--DTLT-LRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAP 171
              L    N   ++ +E  D +T L+   DN++  +    S++S + K+++     L    
Sbjct: 1255 QELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQ 1314

Query: 172  PNVMSQADTVILDKSKIT-VPFLKHGFCENLDDICHSIKQMKEELQKSH----DGEVALT 226
              +  +    +   +K+  V   K+ F E L++   +   +++++   H    D +  + 
Sbjct: 1315 ELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKME 1374

Query: 227  NELQTLQTDPDVHRNGKYDMSPIHQ---------DKMNFIK---EENLDGNLNE-DIKSK 273
            + +  L+T  +V R  + D+  + Q         DK+   K   ++ LD  L + D + +
Sbjct: 1375 DSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQ 1434

Query: 274  RISELEALVKK---LLPFRETVSKFHVHFC---------RKCKKLS-----------KSE 310
                LE   KK   LL   +T+S  +             ++ K LS           K+E
Sbjct: 1435 SACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAE 1494

Query: 311  MHRGKKNEKNNKEIPIT-----GKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLV 365
            + R  K  +   E  ++     GK++ +L+   R        L+Q   EMK +  +    
Sbjct: 1495 LERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRA-------LEQQVEEMKTQLEELEDE 1547

Query: 366  KQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESV-QIQKKVMELESENLNLKSKMKP 424
             Q +  ++      + ++  Q    +Q      +E   Q+ ++V E+E+E  + + +   
Sbjct: 1548 LQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSM 1607

Query: 425  LIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQ 484
             +   + L   ++  E  + +  + +     +L K +   K+C++E     +    +  Q
Sbjct: 1608 AVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQ 1667

Query: 485  NKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLI 544
             K  E+K   +  E  Q+ E L   +  + + Q        E + ++ E+        L 
Sbjct: 1668 AKENEKKLKSMEAEMIQLQEELAAAERAKRQAQ-------QERDELADEIANSSGKGALA 1720

Query: 545  QDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEK 604
             +EK  LE +  QL +E      E ++   E+I     +RL K      LQI +   D  
Sbjct: 1721 LEEKRRLEARIAQLEEEL-----EEEQGNTELI----NDRLKKAN----LQIDQINTD-- 1765

Query: 605  LNLETT-LQESTAARQIMEREIE----NIQTYQSTAEENFLQEIKNAKSEASIYKNSLSE 659
            LNLE +  Q++  ARQ +ER+ +     +Q  + T +  +   I   +++ +  +  L  
Sbjct: 1766 LNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDN 1825

Query: 660  IGKECEMLSKMVMET--KTDNQILKEELKKHSQENIK--FENSISRLTEDKILLENYVRS 715
              KE +   K V  T  K  + +L+ + ++ + E  K   + + +RL +    L+  +  
Sbjct: 1826 ETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQ----LKRQLEE 1881

Query: 716  IENERDTLEFEMRHLQRE 733
             E E        R LQRE
Sbjct: 1882 AEEEAQRANASRRKLQRE 1899



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 111/627 (17%), Positives = 242/627 (38%), Gaps = 94/627 (14%)

Query: 5    KQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESEN-QIQPQSALKVLQQQL 63
            +Q  EE+E    L      L++     +    D+  GC+  +E  + + Q  L+ L Q+ 
Sbjct: 1343 EQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDS-VGCLETAEEVKRKLQKDLEGLSQRH 1401

Query: 64   ESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNV 123
            E  +      L+      + + ++L ++  H  + +  L   ++K           S   
Sbjct: 1402 EE-KVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKY 1460

Query: 124  PSQIHSEDTLTLRTSTDNLS-SNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVI 182
              +    +       T  LS +  +    E    L+  N  +R   T   ++MS  D V 
Sbjct: 1461 AEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFR---TEMEDLMSSKDDV- 1516

Query: 183  LDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNG 242
              KS   +   K    + ++++   ++++++ELQ + D ++ L   LQ ++   +    G
Sbjct: 1517 -GKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQG 1575

Query: 243  KYDMSPIHQDKMNFIKE-ENLDGNLNEDIKSKRIS-----ELEALVKKLLPFRETVSKFH 296
            + + S   + K   +++   ++  L ++ K + ++     +LE  +K L    ++ +K  
Sbjct: 1576 RDEQS--EEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNR 1633

Query: 297  VHFCRKCKKL----------------SKSE-MHRGKKNEKNNKEIPITGKNITD-LKFHS 338
                ++ +KL                S+ E + + K+NEK  K +      + + L    
Sbjct: 1634 DEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAE 1693

Query: 339  RVPRYTLSFLDQTKHEMKDKERQPFLV--------------------KQGSIISENEKTS 378
            R  R      D+   E+ +   +  L                     +QG+    N++  
Sbjct: 1694 RAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLK 1753

Query: 379  KVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQS------- 431
            K N   +Q    +   +++ +++   ++   +LE +N  LK K++ +  T +S       
Sbjct: 1754 KANLQIDQINTDLNLERSHAQKNENARQ---QLERQNKELKVKLQEMEGTVKSKYKASIT 1810

Query: 432  -LIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEE 490
             L  K+   E+QL N  +E+     ++ +TE+  K+ L +          +  + +  E+
Sbjct: 1811 ALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQ----------VDDERRNAEQ 1860

Query: 491  KNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEM 550
               Q      ++ +   QL+  E + Q   A      +R  ++ E        ++D  E 
Sbjct: 1861 YKDQADKASTRLKQLKRQLEEAEEEAQRANA------SRRKLQRE--------LEDATET 1906

Query: 551  LEKKTHQLLKEKSSLGNELKESQLEII 577
             +       +E SSL N+L+   L  +
Sbjct: 1907 ADAMN----REVSSLKNKLRRGDLPFV 1929



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 38/168 (22%), Positives = 76/168 (45%), Gaps = 16/168 (9%)

Query: 559  LKEKSSLGNELKESQLEIIQLKEKERLAK---TEQETLLQIIETVKDEKLNLETTLQEST 615
            L + S    E+   + E+++++EK+  A+   TE ETL   +     EKL L+  LQ  T
Sbjct: 837  LLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMA---EKLQLQEQLQAET 893

Query: 616  ----------AARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECE 665
                      A     ++E+E I        E   +  ++ ++E    + ++ E+ ++ E
Sbjct: 894  ELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLE 953

Query: 666  MLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYV 713
                   + + +    + +LKK  +E I  E+   +L ++K LLE+ +
Sbjct: 954  EEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRI 1001



 Score = 30.8 bits (68), Expect = 5.2
 Identities = 31/128 (24%), Positives = 53/128 (41%), Gaps = 9/128 (7%)

Query: 641 QEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSIS 700
           +E+   + +    +N L+E+    E L   +M  K     L+E+L+  ++   + E   +
Sbjct: 852 EELVKVREKQLAAENRLTEM----ETLQSQLMAEKLQ---LQEQLQAETELCAEAEELRA 904

Query: 701 RLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRREKF 760
           RLT  K  LE     +E   +  E   +HLQ E   +   I  Q  +       S R+K 
Sbjct: 905 RLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNI--QELEEQLEEEESARQKL 962

Query: 761 HFDNYTHE 768
             +  T E
Sbjct: 963 QLEKVTTE 970


>gi|38044112 restin isoform b [Homo sapiens]
          Length = 1392

 Score = 83.2 bits (204), Expect = 9e-16
 Identities = 152/728 (20%), Positives = 309/728 (42%), Gaps = 103/728 (14%)

Query: 62   QLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGD------SVN 115
            +LE   ALR+Q +  +    E+ +    ++ S      + + S++EKL          + 
Sbjct: 468  ELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSL--LQEISSLQEKLEVTRTDHQREIT 525

Query: 116  SLPQSVNVPSQIHSEDTLTLRTSTDNLS-------SNIIIHPSENSDILKNYNNFYRFLP 168
            SL +      + H ++   L T+T+ LS       S +     ENSD++  +        
Sbjct: 526  SLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWK------- 578

Query: 169  TAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNE 228
                   S+ +T I    +  +  LK  F + L        ++K +++K     +   +E
Sbjct: 579  -------SKLETAIASHQQ-AMEELKVSFSKGLGTETAEFAELKTQIEKMR---LDYQHE 627

Query: 229  LQTLQTDPDVHRNGKY-DMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLP 287
            ++ LQ   D  R     +M  +    M  IKE+    N  E I+SK     +A  + L+ 
Sbjct: 628  IENLQNQQDSERAAHAKEMEALRAKLMKVIKEKE---NSLEAIRSKLD---KAEDQHLVE 681

Query: 288  FRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNN------KEIPITGKNITDLKFHSRVP 341
              +T++K          K+ + E+ + K NE+         ++  T + + DL    +  
Sbjct: 682  MEDTLNKLQEAEI----KVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKAS 737

Query: 342  RYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVA---KIQYLQNYL 398
                S + + + +++  E+Q   ++    I +N ++SK +S+T +      K+  LQ  L
Sbjct: 738  SEGKSEMKKLRQQLEAAEKQIKHLE----IEKNAESSKASSITRELQGRELKLTNLQENL 793

Query: 399  KESVQIQKKVMELESENLNLK---------SKMKPLIFTTQSLIQKVETYE---KQLKNL 446
             E  Q+ K+ +E E + L  K         S  + +  T   L QK E +      L+ L
Sbjct: 794  SEVSQV-KETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKL 852

Query: 447  VEEKSTIQSKLSKTEEYSKECLKEFKKI---ISKYNVLQGQNKT-LEEKNIQLSLEKQQM 502
             E  + +++K  + +E  ++ +K  +K+   I++   + G N + L + N +L L+++ +
Sbjct: 853  RENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDV 912

Query: 503  MEA-LDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKE 561
             E  L   K+ E+ +    +I +        + EA K +    ++EK+ LE+K   L K+
Sbjct: 913  EELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKH----EEEKKELERKLSDLEKK 968

Query: 562  KSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIE-TVKDEKLNLETTLQESTAARQI 620
              +  N+ +E +    +   +    KT+ E +LQ ++ T+ D +  L+   +E++   Q 
Sbjct: 969  METSHNQCQELKARYERATSE---TKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQ- 1024

Query: 621  MEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQI 680
               E+E ++     A+         A   A      + ++ KE       + +TK  N  
Sbjct: 1025 ---ELEELRKQADKAK---------AAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAK 1072

Query: 681  LKEELKKHSQENIKFENSISR----LTEDKILLENYVRSIENERDTL---EFEMRHLQRE 733
            L+ EL    + N+K    +++    LT +   +E + + IE  +        ++  LQ E
Sbjct: 1073 LQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEE 1132

Query: 734  YLSLSDKI 741
             + L++++
Sbjct: 1133 NVKLAEEL 1140



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 147/768 (19%), Positives = 310/768 (40%), Gaps = 111/768 (14%)

Query: 6    QHREEDEVDSVLLSASK----ILNSSEGVKESGCS-----DTEYGCIAESENQIQP---- 52
            +H  ++  D + L  SK    I +  + ++E   S      TE    AE + QI+     
Sbjct: 564  EHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLD 623

Query: 53   -QSALKVLQQQLESFQALR---MQTLQNVSMPTENQEENL---------SMEKSHHFEDS 99
             Q  ++ LQ Q +S +A     M+ L+   M    ++EN            E  H  E  
Sbjct: 624  YQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEME 683

Query: 100  KTLHSVEE-KLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHP--SENSDI 156
             TL+ ++E ++    +  L    N  +++    T  L+ + + L     +    SE    
Sbjct: 684  DTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSE 743

Query: 157  LKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGF-CENLDDICHSIKQMKEEL 215
            +K              ++  + +      S IT           NL +    + Q+KE L
Sbjct: 744  MKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETL 803

Query: 216  QKSHDGEVALTNE--LQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSK 273
            +K    E+ +  E   +  +    V R+ +  ++ +HQ      KEE  +  L+ D++  
Sbjct: 804  EK----ELQILKEKFAEASEEAVSVQRSMQETVNKLHQ------KEEQFN-MLSSDLEKL 852

Query: 274  R--ISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNI 331
            R  ++++EA  ++     E + K          ++ K       +  K N E+ +  +++
Sbjct: 853  RENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDV 912

Query: 332  TDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTS----------KVN 381
             +L+          SFL ++  +M  K  Q    ++ +   E EK            K+ 
Sbjct: 913  EELQLKLTKANENASFLQKSIEDMTVKAEQS--QQEAAKKHEEEKKELERKLSDLEKKME 970

Query: 382  SVTEQCVA-KIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYE 440
            +   QC   K +Y +   +   + ++ +  L+   L+ + K+K        L+Q++E   
Sbjct: 971  TSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELR 1030

Query: 441  KQLKNL-----VEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQ- 494
            KQ          E+   I  +++K +  +   L++ K+  +K   LQ +  TL+E N++ 
Sbjct: 1031 KQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAK---LQNELDTLKENNLKN 1087

Query: 495  ----------LSLEKQQMME---ALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNI 541
                      L++E Q+M E    ++ LK    +    ++ +  EN +++ E+   +   
Sbjct: 1088 VEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRD-- 1145

Query: 542  LLIQDEKEMLEKKTHQLLKEKSSLGN----ELKESQLEIIQLKEKERLAKTEQETLLQII 597
                      E  +HQ L+E+ S+ N    E+K+ + + I+  ++E+ +  +  ++   +
Sbjct: 1146 ----------EVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSAL 1195

Query: 598  ETVKDEKL----NLETTLQESTAARQIMEREIENIQTYQSTAE---ENFLQEIKNAKSEA 650
             T KD +L    N  T L+   A+ + +   ++ +++ +   E   +N   ++K  K + 
Sbjct: 1196 LTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQL 1255

Query: 651  SIYKNSLSEIGKECE--------MLSKMVMETKTDNQILKEELKKHSQ 690
            S    +      E E         L+ ++++ +  NQ LK +++  S+
Sbjct: 1256 SSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1303



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 98/482 (20%), Positives = 199/482 (41%), Gaps = 80/482 (16%)

Query: 342 RYTLSFLDQTKHEMKDKERQPFLVKQGSI---------ISENEKTSKVNSVTEQCVAKIQ 392
           R  +  L+Q + E +  E   F V++ SI         +SE  +  ++       V ++ 
Sbjct: 422 REKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVA 481

Query: 393 YLQNYLKE---------SVQIQKKVMELESE-NLNLKSKMKPLIFTTQSLIQKVETYEKQ 442
            L+  L+          S+ + +++  L+ +  +      + +    +    + ET++K+
Sbjct: 482 ELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKE 541

Query: 443 LK-------NLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQL 495
           +K        L +E  +++SKL    + + + +  +K  +     +    + +EE  +  
Sbjct: 542 IKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLE--TAIASHQQAMEELKVSF 599

Query: 496 SLEKQQMMEALDQLKSKEHKTQSDMA--IVNNENNRMSI------EMEAMKTNILLIQDE 547
           S           +LK++  K + D    I N +N + S       EMEA++  ++ +  E
Sbjct: 600 SKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKE 659

Query: 548 KE--------MLEKKTHQLLKEKSSLGNELKESQ-----LEIIQLKEKER---------- 584
           KE         L+K   Q L E     N+L+E++     LE++Q K  E+          
Sbjct: 660 KENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQ 719

Query: 585 LAKTEQETL-LQIIETVKDE-KLNLETTLQESTAA-RQIMEREIENIQTYQSTAEENFLQ 641
           L  TE++ L L  +     E K  ++   Q+  AA +QI   EIE  +  +S+   +  +
Sbjct: 720 LKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIE--KNAESSKASSITR 777

Query: 642 EIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISR 701
           E++  + + +  + +LSE+ +  E L K +       QILKE+  + S+E +  + S+  
Sbjct: 778 ELQGRELKLTNLQENLSEVSQVKETLEKEL-------QILKEKFAEASEEAVSVQRSMQE 830

Query: 702 LTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRREKFH 761
                    N +   E + + L  ++  L+     +  K   +  D  +   I  +EK  
Sbjct: 831 TV-------NKLHQKEEQFNMLSSDLEKLRENLADMEAKF--REKDEREEQLIKAKEKLE 881

Query: 762 FD 763
            D
Sbjct: 882 ND 883



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 114/599 (19%), Positives = 239/599 (39%), Gaps = 64/599 (10%)

Query: 2    SPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQ 61
            S  K+ R++ E     +   +I  ++E  K S  +    G   +  N  +  S +  +++
Sbjct: 742  SEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKE 801

Query: 62   QLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEK---LSGDSVNSLP 118
             LE      +Q L+      E  EE +S+++S   E    LH  EE+   LS D      
Sbjct: 802  TLEK----ELQILKEKF--AEASEEAVSVQRSMQ-ETVNKLHQKEEQFNMLSSDLEKLRE 854

Query: 119  QSVNVPSQIHSEDT-----LTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPN 173
               ++ ++   +D      +  +   +N  + I+    +NS  L   N+  R        
Sbjct: 855  NLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEE 914

Query: 174  VMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVA-LTNELQTL 232
            +  +     L K+     FL+    ++++D+    +Q ++E  K H+ E   L  +L  L
Sbjct: 915  LQLK-----LTKANENASFLQ----KSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDL 965

Query: 233  QTDPDVHRNGKYDMSPIHQDKMNFIKE------ENLDGNL--NEDIKSKRISELEALVKK 284
            +   +   N   ++   ++   +  K       +NL   L   ED       E   L+++
Sbjct: 966  EKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQE 1025

Query: 285  LLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEI--PITGKNITDLKFHSRVPR 342
            L   R+   K       K  + ++  M   ++  K   E    +     T+ K  + +  
Sbjct: 1026 LEELRKQADK------AKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDT 1079

Query: 343  YTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESV 402
               + L   +   K KE    L  +   + E  K  ++ ++ +    K Q L    +E+V
Sbjct: 1080 LKENNLKNVEELNKSKE---LLTVENQKMEEFRK--EIETLKQAAAQKSQQLSALQEENV 1134

Query: 403  QIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEE 462
            ++ +++     E  + +   +        L++  +   K +K+  EEK+++Q  +S T  
Sbjct: 1135 KLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSA 1194

Query: 463  YSKECLKEFKKIISKYNVLQGQN----------KTLEEKNIQLSLE----KQQMMEALDQ 508
               E   E +K+ ++  VL+G+N          +TLE   ++L L+    + Q+ E   Q
Sbjct: 1195 LLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQ 1254

Query: 509  LKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGN 567
            L S    T +     + +      +++ + + I+ +Q + + L+ K  +++ E +  GN
Sbjct: 1255 LSSSSGNTDTQ---ADEDERAQESQIDFLNSVIVDLQRKNQDLKMKV-EMMSEAALNGN 1309


>gi|4506751 restin isoform a [Homo sapiens]
          Length = 1427

 Score = 83.2 bits (204), Expect = 9e-16
 Identities = 152/728 (20%), Positives = 309/728 (42%), Gaps = 103/728 (14%)

Query: 62   QLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGD------SVN 115
            +LE   ALR+Q +  +    E+ +    ++ S      + + S++EKL          + 
Sbjct: 503  ELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSL--LQEISSLQEKLEVTRTDHQREIT 560

Query: 116  SLPQSVNVPSQIHSEDTLTLRTSTDNLS-------SNIIIHPSENSDILKNYNNFYRFLP 168
            SL +      + H ++   L T+T+ LS       S +     ENSD++  +        
Sbjct: 561  SLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWK------- 613

Query: 169  TAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNE 228
                   S+ +T I    +  +  LK  F + L        ++K +++K     +   +E
Sbjct: 614  -------SKLETAIASHQQ-AMEELKVSFSKGLGTETAEFAELKTQIEKMR---LDYQHE 662

Query: 229  LQTLQTDPDVHRNGKY-DMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLP 287
            ++ LQ   D  R     +M  +    M  IKE+    N  E I+SK     +A  + L+ 
Sbjct: 663  IENLQNQQDSERAAHAKEMEALRAKLMKVIKEKE---NSLEAIRSKLD---KAEDQHLVE 716

Query: 288  FRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNN------KEIPITGKNITDLKFHSRVP 341
              +T++K          K+ + E+ + K NE+         ++  T + + DL    +  
Sbjct: 717  MEDTLNKLQEAEI----KVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKAS 772

Query: 342  RYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVA---KIQYLQNYL 398
                S + + + +++  E+Q   ++    I +N ++SK +S+T +      K+  LQ  L
Sbjct: 773  SEGKSEMKKLRQQLEAAEKQIKHLE----IEKNAESSKASSITRELQGRELKLTNLQENL 828

Query: 399  KESVQIQKKVMELESENLNLK---------SKMKPLIFTTQSLIQKVETYE---KQLKNL 446
             E  Q+ K+ +E E + L  K         S  + +  T   L QK E +      L+ L
Sbjct: 829  SEVSQV-KETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKL 887

Query: 447  VEEKSTIQSKLSKTEEYSKECLKEFKKI---ISKYNVLQGQNKT-LEEKNIQLSLEKQQM 502
             E  + +++K  + +E  ++ +K  +K+   I++   + G N + L + N +L L+++ +
Sbjct: 888  RENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDV 947

Query: 503  MEA-LDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKE 561
             E  L   K+ E+ +    +I +        + EA K +    ++EK+ LE+K   L K+
Sbjct: 948  EELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKH----EEEKKELERKLSDLEKK 1003

Query: 562  KSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIE-TVKDEKLNLETTLQESTAARQI 620
              +  N+ +E +    +   +    KT+ E +LQ ++ T+ D +  L+   +E++   Q 
Sbjct: 1004 METSHNQCQELKARYERATSE---TKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQ- 1059

Query: 621  MEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQI 680
               E+E ++     A+         A   A      + ++ KE       + +TK  N  
Sbjct: 1060 ---ELEELRKQADKAK---------AAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAK 1107

Query: 681  LKEELKKHSQENIKFENSISR----LTEDKILLENYVRSIENERDTL---EFEMRHLQRE 733
            L+ EL    + N+K    +++    LT +   +E + + IE  +        ++  LQ E
Sbjct: 1108 LQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEE 1167

Query: 734  YLSLSDKI 741
             + L++++
Sbjct: 1168 NVKLAEEL 1175



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 147/768 (19%), Positives = 310/768 (40%), Gaps = 111/768 (14%)

Query: 6    QHREEDEVDSVLLSASK----ILNSSEGVKESGCS-----DTEYGCIAESENQIQP---- 52
            +H  ++  D + L  SK    I +  + ++E   S      TE    AE + QI+     
Sbjct: 599  EHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLD 658

Query: 53   -QSALKVLQQQLESFQALR---MQTLQNVSMPTENQEENL---------SMEKSHHFEDS 99
             Q  ++ LQ Q +S +A     M+ L+   M    ++EN            E  H  E  
Sbjct: 659  YQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEME 718

Query: 100  KTLHSVEE-KLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHP--SENSDI 156
             TL+ ++E ++    +  L    N  +++    T  L+ + + L     +    SE    
Sbjct: 719  DTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSE 778

Query: 157  LKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGF-CENLDDICHSIKQMKEEL 215
            +K              ++  + +      S IT           NL +    + Q+KE L
Sbjct: 779  MKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETL 838

Query: 216  QKSHDGEVALTNE--LQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSK 273
            +K    E+ +  E   +  +    V R+ +  ++ +HQ      KEE  +  L+ D++  
Sbjct: 839  EK----ELQILKEKFAEASEEAVSVQRSMQETVNKLHQ------KEEQFN-MLSSDLEKL 887

Query: 274  R--ISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNI 331
            R  ++++EA  ++     E + K          ++ K       +  K N E+ +  +++
Sbjct: 888  RENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDV 947

Query: 332  TDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTS----------KVN 381
             +L+          SFL ++  +M  K  Q    ++ +   E EK            K+ 
Sbjct: 948  EELQLKLTKANENASFLQKSIEDMTVKAEQS--QQEAAKKHEEEKKELERKLSDLEKKME 1005

Query: 382  SVTEQCVA-KIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYE 440
            +   QC   K +Y +   +   + ++ +  L+   L+ + K+K        L+Q++E   
Sbjct: 1006 TSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELR 1065

Query: 441  KQLKNL-----VEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQ- 494
            KQ          E+   I  +++K +  +   L++ K+  +K   LQ +  TL+E N++ 
Sbjct: 1066 KQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAK---LQNELDTLKENNLKN 1122

Query: 495  ----------LSLEKQQMME---ALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNI 541
                      L++E Q+M E    ++ LK    +    ++ +  EN +++ E+   +   
Sbjct: 1123 VEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRD-- 1180

Query: 542  LLIQDEKEMLEKKTHQLLKEKSSLGN----ELKESQLEIIQLKEKERLAKTEQETLLQII 597
                      E  +HQ L+E+ S+ N    E+K+ + + I+  ++E+ +  +  ++   +
Sbjct: 1181 ----------EVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSAL 1230

Query: 598  ETVKDEKL----NLETTLQESTAARQIMEREIENIQTYQSTAE---ENFLQEIKNAKSEA 650
             T KD +L    N  T L+   A+ + +   ++ +++ +   E   +N   ++K  K + 
Sbjct: 1231 LTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQL 1290

Query: 651  SIYKNSLSEIGKECE--------MLSKMVMETKTDNQILKEELKKHSQ 690
            S    +      E E         L+ ++++ +  NQ LK +++  S+
Sbjct: 1291 SSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1338



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 115/557 (20%), Positives = 225/557 (40%), Gaps = 91/557 (16%)

Query: 266 LNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNE---KNNK 322
           L  D   + + ELEA + +L    E   +       K + L++ E  + K  +   +  +
Sbjct: 394 LARDGHDQHVLELEAKMDQLRTMVEAADR------EKVELLNQLEEEKRKVEDLQFRVEE 447

Query: 323 EIPITGKNITDLKF-HSRVPRYTLSFL------DQTKHEMKDKERQPFLVKQGSIISENE 375
           E    G   T  K  H+R+     S L      D+ + E++D        K   +  E +
Sbjct: 448 ESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKD 507

Query: 376 KTSKVNSVTE--------QCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIF 427
              +V  V E        +    +    + L+E   +Q+K+    +++    + +K    
Sbjct: 508 LALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLK---- 563

Query: 428 TTQSLIQKVETYEKQLK-------NLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNV 480
             +    + ET++K++K        L +E  +++SKL    + + + +  +K  +     
Sbjct: 564 --EHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLE--TA 619

Query: 481 LQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMA--IVNNENNRMSI------ 532
           +    + +EE  +  S           +LK++  K + D    I N +N + S       
Sbjct: 620 IASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAK 679

Query: 533 EMEAMKTNILLIQDEKE--------MLEKKTHQLLKEKSSLGNELKESQ-----LEIIQL 579
           EMEA++  ++ +  EKE         L+K   Q L E     N+L+E++     LE++Q 
Sbjct: 680 EMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQA 739

Query: 580 KEKER----------LAKTEQETL-LQIIETVKDE-KLNLETTLQESTAA-RQIMEREIE 626
           K  E+          L  TE++ L L  +     E K  ++   Q+  AA +QI   EIE
Sbjct: 740 KCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIE 799

Query: 627 NIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELK 686
             +  +S+   +  +E++  + + +  + +LSE+ +  E L K +       QILKE+  
Sbjct: 800 --KNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKEL-------QILKEKFA 850

Query: 687 KHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHN 746
           + S+E +  + S+           N +   E + + L  ++  L+     +  K   +  
Sbjct: 851 EASEEAVSVQRSMQETV-------NKLHQKEEQFNMLSSDLEKLRENLADMEAKF--REK 901

Query: 747 DPSKTTYISRREKFHFD 763
           D  +   I  +EK   D
Sbjct: 902 DEREEQLIKAKEKLEND 918



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 114/599 (19%), Positives = 239/599 (39%), Gaps = 64/599 (10%)

Query: 2    SPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQ 61
            S  K+ R++ E     +   +I  ++E  K S  +    G   +  N  +  S +  +++
Sbjct: 777  SEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKE 836

Query: 62   QLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEK---LSGDSVNSLP 118
             LE      +Q L+      E  EE +S+++S   E    LH  EE+   LS D      
Sbjct: 837  TLEK----ELQILKEKF--AEASEEAVSVQRSMQ-ETVNKLHQKEEQFNMLSSDLEKLRE 889

Query: 119  QSVNVPSQIHSEDT-----LTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPN 173
               ++ ++   +D      +  +   +N  + I+    +NS  L   N+  R        
Sbjct: 890  NLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEE 949

Query: 174  VMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVA-LTNELQTL 232
            +  +     L K+     FL+    ++++D+    +Q ++E  K H+ E   L  +L  L
Sbjct: 950  LQLK-----LTKANENASFLQ----KSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDL 1000

Query: 233  QTDPDVHRNGKYDMSPIHQDKMNFIKE------ENLDGNL--NEDIKSKRISELEALVKK 284
            +   +   N   ++   ++   +  K       +NL   L   ED       E   L+++
Sbjct: 1001 EKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQE 1060

Query: 285  LLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEI--PITGKNITDLKFHSRVPR 342
            L   R+   K       K  + ++  M   ++  K   E    +     T+ K  + +  
Sbjct: 1061 LEELRKQADK------AKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDT 1114

Query: 343  YTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESV 402
               + L   +   K KE    L  +   + E  K  ++ ++ +    K Q L    +E+V
Sbjct: 1115 LKENNLKNVEELNKSKE---LLTVENQKMEEFRK--EIETLKQAAAQKSQQLSALQEENV 1169

Query: 403  QIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEE 462
            ++ +++     E  + +   +        L++  +   K +K+  EEK+++Q  +S T  
Sbjct: 1170 KLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSA 1229

Query: 463  YSKECLKEFKKIISKYNVLQGQN----------KTLEEKNIQLSLE----KQQMMEALDQ 508
               E   E +K+ ++  VL+G+N          +TLE   ++L L+    + Q+ E   Q
Sbjct: 1230 LLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQ 1289

Query: 509  LKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGN 567
            L S    T +     + +      +++ + + I+ +Q + + L+ K  +++ E +  GN
Sbjct: 1290 LSSSSGNTDTQ---ADEDERAQESQIDFLNSVIVDLQRKNQDLKMKV-EMMSEAALNGN 1344


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 142/703 (20%), Positives = 280/703 (39%), Gaps = 98/703 (13%)

Query: 43   IAESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTL 102
            + ESEN+      L+ LQQ+ E+++  R+  L++    +  + +N S + + H E  K  
Sbjct: 548  LTESENK------LRDLQQEAETYRT-RILELESSLEKSLQENKNQSKDLAVHLEAEKNK 600

Query: 103  HSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNN 162
            H+ E              + V  + H  +  +L+   D L +       E   +LK    
Sbjct: 601  HNKE--------------ITVMVEKHKTELESLKHQQDALWT-------EKLQVLKQ--Q 637

Query: 163  FYRFLPTAPPNVMSQADTVILDKSKIT---VPFLKHGFCENLDDICHSIKQMKEELQKSH 219
            +   +         + +T++ DK  I    +  +     E LD     ++ +  EL +  
Sbjct: 638  YQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVL 697

Query: 220  DGEVALTNELQTLQTDPDVHRN---GKYDMSPIHQDKM--NFIKEENLDGNLNEDIKSKR 274
                 L  EL  L+   D  +     K D    H  +   + IKE  +     E     +
Sbjct: 698  KARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQ 757

Query: 275  ISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDL 334
            I++LE L+K+                 + K L + + H        N E  I  ++  +L
Sbjct: 758  INQLELLLKE-----------------RDKHLKEHQAH------VENLEADIK-RSEGEL 793

Query: 335  KFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYL 394
            +  S       S+   T  + K  E Q   ++Q  +  E E+      V E    K    
Sbjct: 794  QQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVC 853

Query: 395  QNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQ 454
                   +Q+Q  + +LE +N  ++ K+K L    +S ++     ++Q K ++ EK  + 
Sbjct: 854  TELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMI 913

Query: 455  SKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEH 514
             ++ + ++   E L +  K+ +K + +   N+  E K       +++ ME + Q K+KE 
Sbjct: 914  LQMREGQKKEIEILTQ--KLSAKEDSIHILNEEYETK----FKNQEKKMEKVKQ-KAKEM 966

Query: 515  KTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQL 574
            +      +++ E     ++ E   T + L Q EK+   K     + + +S G     S+L
Sbjct: 967  QETLKKKLLDQE---AKLKKELENTALELSQKEKQFNAKMLE--MAQANSAGISDAVSRL 1021

Query: 575  EIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQST 634
            E  Q ++ E L +  +  L  +I ++ ++KLN +    +     Q+ E+E          
Sbjct: 1022 ETNQKEQIESLTEVHRRELNDVI-SIWEKKLNQQAEELQEIHEIQLQEKE---------- 1070

Query: 635  AEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIK 694
                  QE+   K +  ++     E+ KE   L +  ++  T    L+E+LK+ S     
Sbjct: 1071 ------QEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAH--- 1121

Query: 695  FENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSL 737
                ++ L +D+  L+ ++  +E + +    E   LQ + + L
Sbjct: 1122 ----VNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVEL 1160



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 135/619 (21%), Positives = 262/619 (42%), Gaps = 91/619 (14%)

Query: 199  ENLDDICHSIKQMKEEL--------QKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIH 250
            ++L+D     K++ EEL        +K+     A TNEL  + +      N         
Sbjct: 1197 KSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKT---NAILSRISHC 1253

Query: 251  QDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSE 310
            Q +   +KE  L       IK+  +SELEA +++L   + T++   + F +   +L + E
Sbjct: 1254 QHRTTKVKEALL-------IKTCTVSELEAQLRQLTEEQNTLN---ISFQQATHQLEEKE 1303

Query: 311  MHRGKKNEKNNKEIPITGKNITDLKF--HSRVPRYTLSFLDQTKHEMKDKERQPFLVKQG 368
                 K+ K + E  +T K     +     +      S + Q K E+ +      L+K+ 
Sbjct: 1304 NQI--KSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKE- 1360

Query: 369  SIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFT 428
                  EK  +++S+++Q       LQN    S+ + +K   + S       +   L+  
Sbjct: 1361 ---ELKEKKVEISSLSKQLTDLNVQLQN----SISLSEKEAAISSLRKQYDEEKCELLDQ 1413

Query: 429  TQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNV-LQGQNKT 487
             Q L  KV+T  K+  + +E+     +K S+ ++ ++    + +  + +  + L+ ++K 
Sbjct: 1414 VQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKE 1473

Query: 488  LEEKNIQLSLEKQQMMEA----------LDQLKSKEHKTQSDMAI-----------VNNE 526
              EK+ Q++L K+++ +           ++  KSK  K +S++             + + 
Sbjct: 1474 AYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDH 1533

Query: 527  NNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLG----NELKESQLEIIQLKEK 582
              + +IE+E++   +     +K++  K+  Q L+    LG    N +KE++ +I+ L+ +
Sbjct: 1534 ITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQ 1593

Query: 583  ERLAKTEQETLLQIIETV------KDEKLN-LETTLQESTAA-----RQIMEREIENI-Q 629
                K E ET  + +E V      K+E+L  LE  L+  +AA     ++  E++I  I +
Sbjct: 1594 VYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKK 1653

Query: 630  TYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLS---KMVMETKTDNQILKEELK 686
               S  EE   Q  K  +S  S     L E  +E  +L    K V  ++++  I+    K
Sbjct: 1654 QLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAK 1713

Query: 687  K----HSQENIKFENSISRLTEDKILL--------ENYVRSIENERD---TLEFEMR-HL 730
                   QE    +  + +  E+KI +        E  ++ +  E++   +  FEMR   
Sbjct: 1714 NVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQY 1773

Query: 731  QREYLSLSDKICNQHNDPS 749
            Q   + L      QH D S
Sbjct: 1774 QERLIKLEHAEAKQHEDQS 1792



 Score = 63.5 bits (153), Expect = 7e-10
 Identities = 140/664 (21%), Positives = 262/664 (39%), Gaps = 172/664 (25%)

Query: 208  IKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDK-MNFIKEENLDGNL 266
            I QM+E  +K    E+ +  +  + + D     N +Y+    +Q+K M  +K++  +  +
Sbjct: 913  ILQMREGQKK----EIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKE--M 966

Query: 267  NEDIKSKRISELEALVKKL----LPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNK 322
             E +K K + +   L K+L    L   +   +F+       +  S        + E N K
Sbjct: 967  QETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQK 1026

Query: 323  EIPITGKNITDLKFHSRVPRYTLSFLD----------QTKHE--MKDKERQPFLVKQGSI 370
            E     +++T++  H R     +S  +          Q  HE  +++KE++   +KQ  +
Sbjct: 1027 E---QIESLTEV--HRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKIL 1081

Query: 371  ISENEKTSKVNSVT---EQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPL-I 426
            +   EK      +T   E+ V +   L    ++  Q    V  L  +   LK+ ++ L +
Sbjct: 1082 LFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEV 1141

Query: 427  FTTQSLIQKVETYEK--QLKNLVEEK----STIQSKLSKTEEYSKECLKEFKKIISKYNV 480
               +SL +     E+  +LK L EE     S + SKL  T+E       EF+ + S +  
Sbjct: 1142 DLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDE-------EFQSLKSSH-- 1192

Query: 481  LQGQNKTLEEKNIQLSLEKQQM----------MEALDQLKSKE----------------- 513
             +  NK+LE+K+++     +++           EAL + K+ E                 
Sbjct: 1193 -EKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRIS 1251

Query: 514  ---HKT-----------------QSDMAIVNNENNRMSI--------------EMEAMKT 539
               H+T                 ++ +  +  E N ++I              ++++MK 
Sbjct: 1252 HCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKA 1311

Query: 540  NILLIQDEKEMLEKK---THQLLKEKSS------------------LGNELKESQLEI-- 576
            +I  +  EKE L+K+     Q   EK S                  +  ELKE ++EI  
Sbjct: 1312 DIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISS 1371

Query: 577  ---------------IQLKEKE----RLAKTEQETLLQIIETVKDEKLNLETTLQESTAA 617
                           I L EKE     L K   E   ++++ V+D    ++T  +E  +A
Sbjct: 1372 LSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISA 1431

Query: 618  RQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTD 677
                   +E +  + +     F +  K A+S  + ++N++ E+  + E+ SK   E    
Sbjct: 1432 -------LEQVDDWSN----KFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQ 1480

Query: 678  NQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSL 737
              +LKEEL    Q+N +F+     + +DK         +E +   LE E++      + L
Sbjct: 1481 INLLKEEL---DQQNKRFDCLKGEMEDDK-------SKMEKKESNLETELKSQTARIMEL 1530

Query: 738  SDKI 741
             D I
Sbjct: 1531 EDHI 1534



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 97/464 (20%), Positives = 204/464 (43%), Gaps = 81/464 (17%)

Query: 349  DQTKHEMKDKERQPFLVKQGSIISENE-----KTSKVNSVTE--------------QCVA 389
            D++K E K+   +  L  Q + I E E     KT ++ S+ E              + V 
Sbjct: 1505 DKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQ 1564

Query: 390  KIQYLQNYLKES----VQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKN 445
            K+Q+ Q   +E      + ++K++ LE++  ++K++++      + +   V++ E++LK 
Sbjct: 1565 KLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKA 1624

Query: 446  LVEE-KSTIQSKLSKTEEYSKECLKEFKK-IISKYNVLQGQNKT-----LEEKNIQLSLE 498
            L +  +S   +KL++ +  +++ +   KK ++S+    + Q K      L E N +L   
Sbjct: 1625 LEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQER 1684

Query: 499  KQQMMEALDQLKSKEHKTQSDMAIV------------NNENNRMSIEMEAMKTNILLIQ- 545
            ++++    ++LKS E  +QS+  IV              E +      +  +  I ++Q 
Sbjct: 1685 EREVHILEEKLKSVE-SSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQR 1743

Query: 546  --DEKEMLEKKTHQLLKEKSSLGNELK-ESQLEIIQLKEKERLAKTEQETLLQIIETVKD 602
               EKE L ++  Q  +E  S   E++ + Q  +I+L+  E     +Q  +  + E +++
Sbjct: 1744 NLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEE 1803

Query: 603  EKLNLETTLQE---------STAARQIMEREIENIQTYQSTAEENFL------QEIKNAK 647
            +       + +         +  A+Q +E   +++Q    T +E  L      Q+IK   
Sbjct: 1804 KNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQ---KTLQEKELTCQILEQKIKELD 1860

Query: 648  S----EASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLT 703
            S    +  +++  + E+  + E L  +    + D +    EL + + E    E S S L 
Sbjct: 1861 SCLVRQKEVHRVEMEELTSKYEKLQAL---QQMDGRNKPTELLEENTE----EKSKSHLV 1913

Query: 704  EDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHND 747
            + K+L      ++E + + LEF++   +RE   L  +I     D
Sbjct: 1914 QPKLL-----SNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKD 1952



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 151/760 (19%), Positives = 303/760 (39%), Gaps = 142/760 (18%)

Query: 5    KQHREEDEVDSVLLS-ASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQQL 63
            K  ++E  +++ L S  ++I+   + + +          + ++ NQ Q     K L Q+L
Sbjct: 1508 KMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQ-QKDIEHKELVQKL 1566

Query: 64   ESFQAL-------------RMQTLQN--VSMPTENQEENLSMEKSHHFEDSKT--LHSVE 106
            + FQ L             ++ TL+N   SM  E + +   +E  +    SK   L ++E
Sbjct: 1567 QHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALE 1626

Query: 107  EKLSGDSVNSLPQSVNVPSQ----IHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNN 162
            ++L  +S   L +      Q    I  +    +    +        H SE +  L+    
Sbjct: 1627 DRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQERER 1686

Query: 163  FYRFLPTAPPNV-MSQADTVILDKS-KITVPFLKHGFCENLDDICHSIKQMKEELQKSHD 220
                L     +V  SQ++T+I+ +S K    + +    ++   +  + ++    LQ++  
Sbjct: 1687 EVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLT 1746

Query: 221  GEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEA 280
             +  L   LQ +  + +   +  ++M   +Q+++  IK E+ +   +ED     I  L+ 
Sbjct: 1747 EKEKL---LQRVGQEKEETVSSHFEMRCQYQERL--IKLEHAEAKQHED--QSMIGHLQE 1799

Query: 281  LVKKLLPFRETVSKFHVHFCRKCKKLSKS-EMHRGKKNEKNNKEIPITGKNI-TDLKFHS 338
             +++                 K KK S     H  K+  KNN +     +N+  D++   
Sbjct: 1800 ELEE-----------------KNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTL 1842

Query: 339  RVPRYTLSFLDQTKHEMKDKERQPFLVKQGSI--ISENEKTSKVNSVTEQCVAKIQYLQN 396
            +    T   L+Q     K KE    LV+Q  +  +   E TSK          K+Q LQ 
Sbjct: 1843 QEKELTCQILEQ-----KIKELDSCLVRQKEVHRVEMEELTSKYE--------KLQALQQ 1889

Query: 397  Y---------LKESVQ-------IQKKVME-LESENLNLKSKMKPLIFTTQSLIQKVETY 439
                      L+E+ +       +Q K++  +E+++ +L+ K+       Q L +++   
Sbjct: 1890 MDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRL 1949

Query: 440  EKQLKNLVEEKSTIQSKLSKT-EEYSKECLKE------------FKKIISKYNVLQGQNK 486
            +K L+ L +E       L K  ++  +E +K+             K+++ ++N    Q +
Sbjct: 1950 QKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKE 2009

Query: 487  TLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMS-----------IEME 535
               E  I+ ++ K Q +EA + L+S + +T   +  +  +++ +               E
Sbjct: 2010 QELEMTIKETINKAQEVEA-ELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREE 2068

Query: 536  AMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQ 595
             M   +  +Q + E L+KK  Q L+++ + GN+     + I++L          Q  L Q
Sbjct: 2069 EMTAKVRDLQTQLEELQKKYQQKLEQEENPGND----NVTIMEL----------QTQLAQ 2114

Query: 596  IIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEEN-FLQEIKNAKSEASIYK 654
                + D KL             Q    +I N++      E+N +   +       ++Y 
Sbjct: 2115 KTTLISDSKLK-----------EQEFREQIHNLEDRLKKYEKNVYATTVGTPYKGGNLYH 2163

Query: 655  NSLSEIGK--ECEMLSKMVM------ETKTDNQILKEELK 686
              +S  G+  E E L K++       ETKT  +++   LK
Sbjct: 2164 TDVSLFGEPTEFEYLRKVLFEYMMGRETKTMAKVITTVLK 2203



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 73/381 (19%), Positives = 169/381 (44%), Gaps = 86/381 (22%)

Query: 430 QSLIQKVETYEKQLKN--------------LVEEKSTIQSKLSKTEEYSKECLKEFKKII 475
           + LIQ++   E+ L +              L  EK  +Q  LS++++ S   + E ++ +
Sbjct: 137 EQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREEL 196

Query: 476 -----SKYNVLQGQNKTLEEKN-------IQLSLEKQQM---------MEALDQLK---- 510
                +K ++ +  + +LEEK+        Q+SL KQ++         ++ L QL+    
Sbjct: 197 QMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAE 256

Query: 511 --SKEHKTQSD------------------MAIVNNEN--NRMSIEMEAMKTNILLIQDEK 548
             +KE   +SD                    +   EN   R    +++ K    L+  EK
Sbjct: 257 VFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEK 316

Query: 549 EMLEKKTHQLLKE-----------KSSLGNELKESQLEIIQLKEKERLAKTE-QETLLQI 596
           E L+++  + L+E           K+ L  +L++++  I QL++ + +   E +  + + 
Sbjct: 317 EALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHET 376

Query: 597 IETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNS 656
           +E  ++E   L + +++ T        + E ++  +  +E    +E++ A S A   + +
Sbjct: 377 LEMKEEEIAQLRSRIKQMTT-------QGEELREQKEKSERAAFEELEKALSTAQKTEEA 429

Query: 657 LSEIGKECEMLSKMVMETKTDNQI-LKEELKKHSQENIKFENSISRLTEDKI--LLENYV 713
             ++  E +   K + +T  + +I L++EL +  QE +   + + + +E++I  L + + 
Sbjct: 430 RRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVV---DVMKKSSEEQIAKLQKLHE 486

Query: 714 RSIENERDTLEFEMRHLQREY 734
           + +  +   L  +++  +RE+
Sbjct: 487 KELARKEQELTKKLQTREREF 507


>gi|58530840 desmoplakin isoform I [Homo sapiens]
          Length = 2871

 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 158/800 (19%), Positives = 309/800 (38%), Gaps = 109/800 (13%)

Query: 45   ESEN----QIQPQSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSK 100
            E EN    +++ + A+K  + ++E  + L    LQ         E  L+  ++H+ E+  
Sbjct: 1149 EKENLGWQKLESEKAIKEKEYEIERLRVL----LQEEGTRKREYENELAKVRNHYNEEMS 1204

Query: 101  TLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSE----NSDI 156
             L +  E      +N    ++   S    +D+  LR   D LS        E    N  I
Sbjct: 1205 NLRNKYET----EINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSI 1260

Query: 157  LKNYNNFYRFLPTAPPNVMSQ--ADTVILDKSKITVPFLKHGFCENLDDICH-------- 206
            L+      R    A  N + Q    + I+ K +     LK    +  +D           
Sbjct: 1261 LQATEQRRR----AEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEA 1316

Query: 207  ---------SIKQMKEELQKSHDGEVALTNELQTLQTDPD---VHRNGKYDM------SP 248
                      I+++K E Q+         NEL  ++ + D   +    +++       + 
Sbjct: 1317 AKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTT 1376

Query: 249  IHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSK 308
            IHQ  M   KEE+  G   +     R  E  +L +++   + T+++   +  R+ ++  +
Sbjct: 1377 IHQLTMQ--KEEDTSGYRAQIDNLTR--ENRSLSEEIKRLKNTLTQTTENL-RRVEEDIQ 1431

Query: 309  SEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQG 368
             +   G +  +  +++ +  + +T ++    V RY  S LD     ++DK ++   +KQ 
Sbjct: 1432 QQKATGSEVSQRKQQLEVELRQVTQMRTEESV-RYKQS-LDDAAKTIQDKNKEIERLKQ- 1488

Query: 369  SIISENEKTSKVNSVTEQCVAKIQY-LQNYLKESVQIQKKVMELESENLNLKSKMKPLIF 427
             +I +     K        + ++QY LQ     + +   K+   E E   L+   + +  
Sbjct: 1489 -LIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQ 1547

Query: 428  TTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKT 487
                  Q +  ++  LK L  +K  ++ +L++ +  + E   + KK+  +   L+G  ++
Sbjct: 1548 ERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEE---LEGMRRS 1604

Query: 488  LEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNN----------ENNRMSIEMEAM 537
            L+E+ I+++   QQ+ +A    K  E   +    +++           E  R+S E+EA+
Sbjct: 1605 LKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEAL 1664

Query: 538  KTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQII 597
            +  +L  Q+  +    +     K        L ES++EI              E L  + 
Sbjct: 1665 RRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEI--------------ERLQSLT 1710

Query: 598  ETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSL 657
            E +  E L LE  L+        +  E ++++  +S A+ +    I   +S+  I  N  
Sbjct: 1711 ENLTKEHLMLEEELRN-------LRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRT 1763

Query: 658  SEIG--------------KECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLT 703
             E+               +E E   K  +E     Q  K +  +  QE       I  L 
Sbjct: 1764 LELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLE 1823

Query: 704  EDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRREKFHFD 763
            +DK  L+     +   + TLE E R  QR  L    +      +  KT Y SR+E+    
Sbjct: 1824 QDKARLQRLEDELNRAKSTLEAETRVKQR--LECEKQQIQNDLNQWKTQY-SRKEEAIRK 1880

Query: 764  NYTHEDTSSPQSRPLASDLK 783
              +  + S  +   L S+++
Sbjct: 1881 IESEREKSEREKNSLRSEIE 1900



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 91/408 (22%), Positives = 169/408 (41%), Gaps = 84/408 (20%)

Query: 392  QYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKS 451
            Q LQ Y  E  Q + K+  LE     LK + +      +S  Q ++    Q+K L E+ +
Sbjct: 1060 QNLQKYQAECSQFKAKLASLEE----LKRQAE---LDGKSAKQNLDKCYGQIKELNEKIT 1112

Query: 452  TIQSKLSKTEEYSKECLKEFKKIISKYNVLQ----------GQNKTLEEKNI-QLSLEKQ 500
             +  ++   +   K     F +  + Y+ LQ          G  K   EK I +   E +
Sbjct: 1113 RLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIE 1172

Query: 501  QMMEALDQLKSKEHKTQSDMAIVNNE--------NNRMSIEMEAMKTNILLIQDEKEMLE 552
            ++   L +  +++ + ++++A V N          N+   E+   KT I  I  +KE   
Sbjct: 1173 RLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDS 1232

Query: 553  KKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQ 612
            K     L   S    +LK+   EI++L +              I++  +  +   E  LQ
Sbjct: 1233 KNLRNQLDRLSRENRDLKD---EIVRLND-------------SILQATEQRRRAEENALQ 1276

Query: 613  ESTAARQIMER----EIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLS 668
            +     +IM++    EIE  Q  Q  +E+N            + +K SL E        +
Sbjct: 1277 QKACGSEIMQKKQHLEIELKQVMQQRSEDN------------ARHKQSLEE-------AA 1317

Query: 669  KMVMETKTDNQILKEELKKHSQENIKFENSISRL----TEDKILLEN------------- 711
            K + +   + + LK E ++ ++   ++EN +S++     E+ I L+N             
Sbjct: 1318 KTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTI 1377

Query: 712  YVRSIENERDTLEF--EMRHLQREYLSLSDKICNQHNDPSKTTYISRR 757
            +  +++ E DT  +  ++ +L RE  SLS++I    N  ++TT   RR
Sbjct: 1378 HQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRR 1425



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 84/408 (20%), Positives = 182/408 (44%), Gaps = 78/408 (19%)

Query: 202  DDICHSIKQMKEELQKSH----DGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFI 257
            +D C   K+++EEL+       +  + +TN  Q L+    V +  + D+           
Sbjct: 1586 EDSCKR-KKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQ--------- 1635

Query: 258  KEENLDGNLNEDIKSKR-----ISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMH 312
            + + LDG+L E  +++       SE+EAL ++LL  +E+V + H+               
Sbjct: 1636 QRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHL--------------- 1680

Query: 313  RGKKNEKNNKEIPITGKNITDLKFH-SRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSII 371
               +NE   K I    +++ + K    R+   T +   +  H M ++E +   ++   + 
Sbjct: 1681 ---RNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKE--HLMLEEELRNLRLEYDDLR 1735

Query: 372  -SENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQ 430
               +E  S  N+   +  +++Q   N    ++++Q  + +L+ E  NL+           
Sbjct: 1736 RGRSEADSDKNATILELRSQLQISNN---RTLELQGLINDLQRERENLR----------- 1781

Query: 431  SLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEE 490
               Q++E ++KQ    +E  + IQ    +++    + ++E + ++ K  VL+     L+ 
Sbjct: 1782 ---QEIEKFQKQA---LEASNRIQ----ESKNQCTQVVQERESLLVKIKVLEQDKARLQR 1831

Query: 491  KNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEM 550
               +L+  K  + EA  ++K +    + +   + N+ N+   +    +  I  I+ E+E 
Sbjct: 1832 LEDELNRAKSTL-EAETRVKQR---LECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREK 1887

Query: 551  LEKKTHQLLKEKSSLGNELKESQLEIIQLKE--KERLAKTEQETLLQI 596
             E       +EK+SL +E++  Q EI +++E  + +L  + +ET  Q+
Sbjct: 1888 SE-------REKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQL 1928



 Score = 39.7 bits (91), Expect = 0.011
 Identities = 111/615 (18%), Positives = 238/615 (38%), Gaps = 153/615 (24%)

Query: 58   VLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSL 117
            V  Q +  FQ     +L+ + +  +  EE L+  K    EDS     +EE+L G   +  
Sbjct: 1551 VKDQDITRFQ----NSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLK 1606

Query: 118  PQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQ 177
             Q++ +                 NL+  +     E + I+K           +  ++  Q
Sbjct: 1607 EQAIKI----------------TNLTQQL-----EQASIVKK---------RSEDDLRQQ 1636

Query: 178  ADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPD 237
             D                     LD      ++ +EEL++      AL  +L  LQ    
Sbjct: 1637 RDV--------------------LDGHLREKQRTQEELRRLSSEVEALRRQL--LQEQES 1674

Query: 238  VHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHV 297
            V              K   ++ E+    + +  KS+ ++E +  +++L    E ++K H+
Sbjct: 1675 V--------------KQAHLRNEHFQKAIED--KSRSLNESKIEIERLQSLTENLTKEHL 1718

Query: 298  HFCRKCK--KLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVP---RYTLSFLDQTK 352
                + +  +L   ++ RG+    ++       KN T L+  S++      TL       
Sbjct: 1719 MLEEELRNLRLEYDDLRRGRSEADSD-------KNATILELRSQLQISNNRTLELQGLIN 1771

Query: 353  HEMKDKE--RQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVME 410
               +++E  RQ     Q   +   E ++++     QC   +Q      +ES+ ++ KV+E
Sbjct: 1772 DLQRERENLRQEIEKFQKQAL---EASNRIQESKNQCTQVVQE-----RESLLVKIKVLE 1823

Query: 411  LESENL----NLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSK----LSKTEE 462
             +   L    +  ++ K  +     + Q++E  ++Q++N + +  T  S+    + K E 
Sbjct: 1824 QDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIES 1883

Query: 463  YSKECLKEFKKIISKYNVLQGQNKTLEEK------------NIQLSLEKQQMMEALDQLK 510
              ++  +E   + S+   LQ + K +EE+              QL  E+ +    +D+L+
Sbjct: 1884 EREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLR 1943

Query: 511  S------KEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQ-DEKEMLEKKT-HQLLKEK 562
                   +E +T+ +  +     +   +  + ++  +  +Q  E ++++K T  +LLK K
Sbjct: 1944 QRPYGSHRETQTECEWTV-----DTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGK 1998

Query: 563  SSLGNELKESQ-------------------LEIIQLKEKERLAKTEQETLLQ-------I 596
             S+     E Q                     +++ K K+ ++      LL+       I
Sbjct: 1999 KSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGI 2058

Query: 597  IETVKDEKLNLETTL 611
            I+  ++EKL +++ +
Sbjct: 2059 IDPHRNEKLTVDSAI 2073


>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
          Length = 1684

 Score = 81.3 bits (199), Expect = 3e-15
 Identities = 133/586 (22%), Positives = 236/586 (40%), Gaps = 62/586 (10%)

Query: 182 ILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHR- 240
           +++K K  +  L   FC  ++     ++ +KE+ QK    E++  NE  T  +D +  + 
Sbjct: 400 VIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQK----EISELNE--TFLSDSEKEKL 453

Query: 241 NGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFC 300
              +++  + +   N +++E  +  LN +     + E+  +++  L   E+  K    F 
Sbjct: 454 TLMFEIQGLKEQCEN-LQQEKQEAILNYE----SLREIMEILQTELG--ESAGKISQEF- 505

Query: 301 RKCKKLSKSEMHR---------GKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQT 351
              K+   S++H           +K+        + G+N   L     VP      L+ T
Sbjct: 506 ESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPE-----LENT 560

Query: 352 KHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMEL 411
              +++K     L          E   K+NS+TE+    I  L+N  +E     KK    
Sbjct: 561 IKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCERE 620

Query: 412 ESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEF 471
           E   L L  K++  I     L QKV      L+  ++EK     KL K        + + 
Sbjct: 621 ERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEK-------LMVQM 673

Query: 472 KKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMS 531
           K +     VL  + K+L E+N +LS EK+Q+   L+   S++        I   E     
Sbjct: 674 KVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQL 733

Query: 532 IEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQE 591
           +  E    N LL  ++ + L  KT QL      +G+E+ E   E    K+   + +   E
Sbjct: 734 MVEEQDNLNKLLENEQVQKLFVKT-QLYGFLKEMGSEVSEDSEE----KDVVNVLQAVGE 788

Query: 592 TLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEAS 651
           +L +I     +EK NL     E       +E+EI+ +Q       E     +++ + E  
Sbjct: 789 SLAKI----NEEKCNLAFQRDEKVLE---LEKEIKCLQEESVVQCEELKSLLRDYEQEKV 841

Query: 652 IYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLEN 711
           + +  L EI  E E L   ++E K  N+  + E      +N+  +      T  K  + N
Sbjct: 842 LLRKELEEIQSEKEALQSDLLEMKNANEKTRLE-----NQNLLIQVEEVSQTCSKSEIHN 896

Query: 712 -----YVRSIENERDTLE-FEMRHLQREYLSLSDKICNQ---HNDP 748
                +++  EN +  LE  E+R  + E + L D +       NDP
Sbjct: 897 EKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDP 942



 Score = 80.5 bits (197), Expect = 6e-15
 Identities = 139/672 (20%), Positives = 278/672 (41%), Gaps = 97/672 (14%)

Query: 85   EENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHS---EDTLTLRTST-D 140
            +E LS E    +E++  L S +++LS D    L Q  +V  + H    E  L L     D
Sbjct: 680  KEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQD 739

Query: 141  NLSSNIIIHPSENSDILKNY--NNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFC 198
            NL+  +     EN  + K +     Y FL      V   ++    +K  + V        
Sbjct: 740  NLNKLL-----ENEQVQKLFVKTQLYGFLKEMGSEVSEDSE----EKDVVNV-------- 782

Query: 199  ENLDDICHSIKQMKEE---LQKSHDGEVA-LTNELQTLQTDPDVH-RNGKYDMSPIHQDK 253
              L  +  S+ ++ EE   L    D +V  L  E++ LQ +  V     K  +    Q+K
Sbjct: 783  --LQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEK 840

Query: 254  MNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFH-------VHFCRKCKKL 306
            +   KE        E+I+S++    EAL   LL  +    K         +      +  
Sbjct: 841  VLLRKEL-------EEIQSEK----EALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTC 889

Query: 307  SKSEMHRGKKN----EKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQP 362
            SKSE+H  K+     E  N +  +  K + D +    + + +L+     K++     ++ 
Sbjct: 890  SKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKEL 949

Query: 363  FLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKM 422
                +       EK  K+N +    V   + L +  KE+  +++++  L SE   L + M
Sbjct: 950  EEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASM 1009

Query: 423  KPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECL----------KEFK 472
            + LI   +S    +  YEKQ + L  EK    +   + E+ +++             + +
Sbjct: 1010 RDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNE 1069

Query: 473  KIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSI 532
             ++++   LQ   K LE + +++   K  + + L+  K ++ +   + A   NE   + +
Sbjct: 1070 DLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQV 1129

Query: 533  EMEAMKTNILLIQDEKEMLEKKTHQ-------------LLKEKSSLGNELKESQLEIIQL 579
            +++  K  +     E E+++K   Q             L+KE   L  +L     +I  L
Sbjct: 1130 QLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKE---LNQKLTNKNNKIEDL 1186

Query: 580  KEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIM-EREIENIQTYQSTAEEN 638
            +++ ++ K +QETL + I +++      E   +++T  +Q++ + + E   + Q+  +  
Sbjct: 1187 EQEIKIQKQKQETLQEEITSLQSSVQQYE---EKNTKIKQLLVKTKKELADSKQAETDHL 1243

Query: 639  FLQ-----EIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENI 693
             LQ     E++ ++ +  +YK  L+EI  E   +          ++ LK   ++H +   
Sbjct: 1244 ILQASLKGELEASQQQVEVYKIQLAEITSEKHKI----------HEHLKTSAEQHQRTLS 1293

Query: 694  KFENSISRLTED 705
             ++  ++ L E+
Sbjct: 1294 AYQQRVTALQEE 1305



 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 118/556 (21%), Positives = 242/556 (43%), Gaps = 64/556 (11%)

Query: 193  LKHGFCENLDDICHSIKQMK---EELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPI 249
            L+  F E  D +  ++ +++   E+L    +    L N ++ LQ      +NG Y +S  
Sbjct: 523  LRTAFTEK-DALLETVNRLQGENEKLLSQQELVPELENTIKNLQ-----EKNGVYLLSLS 576

Query: 250  HQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKS 309
             +D M  +KE  L+G +N   + K     +  + KL    E +  FH    +KC++  + 
Sbjct: 577  QRDTM--LKE--LEGKINSLTEEK-----DDFINKLKNSHEEMDNFH----KKCEREERL 623

Query: 310  EMHRGKKNEKN---NKEIP-----ITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQ 361
             +  GKK E+    N E+      +TG     LK   +  +     + Q K   +DKE  
Sbjct: 624  ILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKE-- 681

Query: 362  PFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNY-----LKESV-QIQKKV--MELES 413
               V    + S  E+ +K++S  +Q    ++   +      LKE + Q++KK+  M  E 
Sbjct: 682  ---VLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQ 738

Query: 414  ENLN--LKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEF 471
            +NLN  L+++    +F    L   ++    ++    EEK  +    +  E  +K  + E 
Sbjct: 739  DNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAK--INEE 796

Query: 472  KKIISKYNVLQGQNKTLE-EKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRM 530
            K  ++     Q   K LE EK I+  L+++ +++  ++LKS     + +  ++  E   +
Sbjct: 797  KCNLA----FQRDEKVLELEKEIKC-LQEESVVQC-EELKSLLRDYEQEKVLLRKELEEI 850

Query: 531  SIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQ 590
              E EA+++++L +++  E    +   LL +   +     +S++      EKE+    E 
Sbjct: 851  QSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIH----NEKEKCFIKEH 906

Query: 591  ETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEA 650
            E L  ++E  +      E  L + + A+        +++    ++ +   ++I+N + E 
Sbjct: 907  ENLKPLLEQKELRDRRAELILLKDSLAKS------PSVKNDPLSSVKELEEKIENLEKEC 960

Query: 651  SIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLE 710
               +  +++I        K +  ++ + Q +KEEL+    E  +   S+  L +     +
Sbjct: 961  KEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYK 1020

Query: 711  NYVRSIENERDTLEFE 726
            N +   E + + L+ E
Sbjct: 1021 NLLLEYEKQSEQLDVE 1036



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 131/755 (17%), Positives = 307/755 (40%), Gaps = 88/755 (11%)

Query: 23   ILNSSEGVKESGCSDTEYGC---IAESENQIQPQSALKVLQQQLESFQALRMQTLQNVSM 79
            ++N  + V ES     E  C       E  ++ +  +K LQ++      ++ + L+  S+
Sbjct: 779  VVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEE----SVVQCEELK--SL 832

Query: 80   PTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTST 139
              + ++E + + K     + + + S +E L  D +    ++ N  +++ +++ L      
Sbjct: 833  LRDYEQEKVLLRK-----ELEEIQSEKEALQSDLLEM--KNANEKTRLENQNLLIQVEEV 885

Query: 140  DNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCE 199
                S   IH  +    +K + N    L         +A+ ++L  S    P +K+    
Sbjct: 886  SQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDR-RAELILLKDSLAKSPSVKNDPLS 944

Query: 200  NLDDICHSI----KQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMN 255
            ++ ++   I    K+ KE+ +K +  ++      + L +     +  K ++  +  +K  
Sbjct: 945  SVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEK-- 1002

Query: 256  FIKEENLDGNLNEDIKSKR-----ISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSE 310
                + L  ++ + I+        + E E   ++L   +E  + F        ++L  S 
Sbjct: 1003 ----DQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNST 1058

Query: 311  MHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSI 370
            +     N  N   +      I  L+ ++++    +  + + K  M DKE +   +++   
Sbjct: 1059 LQCETINSDNEDLLA----RIETLQSNAKLLEVQILEVQRAK-AMVDKELEAEKLQKEQK 1113

Query: 371  ISENEKT-SKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNL---KSKMKPLI 426
            I E+  T +++  +  Q   + + LQ  ++E   ++K   +    N+ +   +  MK L 
Sbjct: 1114 IKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELN 1173

Query: 427  FTTQSLIQKVETYEKQLK-------NLVEEKSTIQSKLSKTEEYS----------KECLK 469
                +   K+E  E+++K        L EE +++QS + + EE +          K+ L 
Sbjct: 1174 QKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELA 1233

Query: 470  EFKKIISKYNVLQGQNK-TLEEKNIQLSLEKQQMMEALDQ-------LKSKEHKTQSDMA 521
            + K+  + + +LQ   K  LE    Q+ + K Q+ E   +       LK+   + Q  ++
Sbjct: 1234 DSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLS 1293

Query: 522  IVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSL--------GNELKESQ 573
                    +  E  A K     +  E E  + + H +LK++ +         G + +   
Sbjct: 1294 AYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREH 1353

Query: 574  LEII--QLKEKERLAKTEQETLLQIIETVKDEKLNL----ETTLQESTAARQIMEREIEN 627
            LE++  QLK K + ++   +  +  ++T++ E   L       LQE+ +    +  ++ +
Sbjct: 1354 LEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCS 1413

Query: 628  IQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKK 687
            IQ+     +    Q +    S+  + +NS  +  +  +   +  +ET      L+++L K
Sbjct: 1414 IQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVET------LQQQLSK 1467

Query: 688  HSQENIKFENSISRLTEDKILLENYVRSIENERDT 722
               +  + +N  +  T   +  +  ++++   R+T
Sbjct: 1468 MEAQLFQLKNEPT--TRSPVSSQQSLKNLRERRNT 1500



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 85/419 (20%), Positives = 187/419 (44%), Gaps = 50/419 (11%)

Query: 348 LDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKK 407
           LD    E  + E+Q   +K+ +I  + E    V  + +      Q   NY+KE   ++ +
Sbjct: 78  LDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNE 137

Query: 408 VMELES----ENLNLKSKMKPLIFTTQSLIQKVE---TYEKQLKNLVEEKSTI------- 453
           +M + S    +  NL+ +++  + T   L ++++     E  +K L EE   I       
Sbjct: 138 LMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQ 197

Query: 454 ----QSKLSKTEEYSKECLKEFKKIISKYNVLQGQN-KTLEEKNIQL-SLEKQQMMEALD 507
               Q +L  T +  KE + + + II   +    +N  +L+E+ +QL ++ ++++ E + 
Sbjct: 198 ILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMC 257

Query: 508 QLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGN 567
           Q+++   + ++++  +N     +  + EA          EK + +K   +L   + +  N
Sbjct: 258 QIEASAKEHEAEINKLNELKENLVKQCEA---------SEKNIQKKYECELENLRKATSN 308

Query: 568 ELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKL-NLETTLQESTAARQIMEREI- 625
             +++Q+  I L+E               +E V +EK+ +LE TL+E  +   I++ E+ 
Sbjct: 309 ANQDNQICSILLQEN------------TFVEQVVNEKVKHLEDTLKELESQHSILKDEVT 356

Query: 626 --ENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECE--MLSKMVMETKTDNQIL 681
              N++       ++   E  + + +     N L  + KE +  ++ K+  E    N+  
Sbjct: 357 YMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELL-LAKEEQGCVIEKLKSELAGLNKQF 415

Query: 682 KEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDK 740
              +++H++E    +    +  E   L E ++   E E+ TL FE++ L+ +  +L  +
Sbjct: 416 CYTVEQHNREVQSLKEQHQK--EISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQE 472



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 80/380 (21%), Positives = 164/380 (43%), Gaps = 67/380 (17%)

Query: 435 KVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQ 494
           K+ET  K+  +L++        + K +    E  KE +++ SK  V +G    ++     
Sbjct: 21  KLETLPKE--DLIKFAKKQMMLIQKAKSRCTELEKEIEELRSK-PVTEGTGDIIKA---- 73

Query: 495 LSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEM---- 550
                  + E LD L  ++ +T+     +  EN +M  E+E   T +     E E     
Sbjct: 74  -------LTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHIN 126

Query: 551 ----LEKKTHQLL-------KEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIET 599
               +E   ++L+       ++K++L  +L+E+    ++L E+ +     ++ + ++ E 
Sbjct: 127 YVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEE 186

Query: 600 V-------KDEKLNLETTLQESTAARQIMEREIENI-----QTYQ---STAEENFLQ--- 641
           +       +++ L L+  L  +T  ++    +++NI     Q YQ   ++ +E  LQ   
Sbjct: 187 IEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKA 246

Query: 642 ----EIKN--AKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKF 695
               E+K    + EAS  K   +EI K  E+   +V + +   + ++   KK+  E    
Sbjct: 247 IHQEEVKELMCQIEASA-KEHEAEINKLNELKENLVKQCEASEKNIQ---KKYECELENL 302

Query: 696 ENSISRLTEDK-----ILLEN-YVRSIENER-DTLEFEMRHLQREYLSLSDKICNQHNDP 748
             + S   +D      +L EN +V  + NE+   LE  ++ L+ ++  L D++   +N  
Sbjct: 303 RKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLK 362

Query: 749 SKTTYISRREKFHFDNYTHE 768
            K    ++  K   D + HE
Sbjct: 363 LKLEMDAQHIK---DEFFHE 379



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 57/266 (21%), Positives = 117/266 (43%), Gaps = 35/266 (13%)

Query: 350  QTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQY----------LQNYLK 399
            +T+   +++E    L+ Q  I  ++ + +   +V+E    + ++          LQ  + 
Sbjct: 1343 ETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVS 1402

Query: 400  ESVQIQKKVMELESENLNLKSKMKPLI--FTTQSLIQKVETYEKQLKNLVEEK----STI 453
            +  ++++K+  ++SEN+ +KS+    +   T+Q+ + +  ++  Q+++L EE      T+
Sbjct: 1403 KEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLR-NSFRDQVRHLQEEHRKTVETL 1461

Query: 454  QSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSL--------EKQQMMEA 505
            Q +LSK E    + LK      S  +  Q      E +N  L L        E+ + ME 
Sbjct: 1462 QQQLSKMEAQLFQ-LKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMET 1520

Query: 506  LD--QLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKS 563
             D   + S    TQS   ++N+   ++       +  +   +  KE L +K     K   
Sbjct: 1521 TDTESVSSASTYTQSLEQLLNSPETKL-------EPPLWHAEFTKEELVQKLSSTTKSAD 1573

Query: 564  SLGNELKESQLEIIQLKEKERLAKTE 589
             L   L+E++     L E+ +L K+E
Sbjct: 1574 HLNGLLRETEATNAILMEQIKLLKSE 1599



 Score = 31.2 bits (69), Expect = 4.0
 Identities = 67/330 (20%), Positives = 142/330 (43%), Gaps = 29/330 (8%)

Query: 208  IKQMKEELQKSHDGEVALTNELQTLQTDPD--VHRNGKYDMSPIH-----QDKMNFIKEE 260
            I Q+K +LQ S +      +ELQTLQ++ D  + R+ K     +      ++K+  I+ E
Sbjct: 1358 IDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSE 1417

Query: 261  NLDGNLNEDIKSKRISELEALVKKLL-PFRETVSKFHVHFCRKC----KKLSKSEMHRGK 315
            N+   + +   ++ +S+L +  + L   FR+ V        +      ++LSK E    +
Sbjct: 1418 NM---MMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQ 1474

Query: 316  -KNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISEN 374
             KNE   +    + +++ +L+         L     T+ E +  E         S+ S +
Sbjct: 1475 LKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGME----TTDTESVSSAS 1530

Query: 375  EKTSKVNSVTEQCVAKIQ---YLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQS 431
              T  +  +      K++   +   + KE + +QK     +S + +L   ++    T   
Sbjct: 1531 TYTQSLEQLLNSPETKLEPPLWHAEFTKEEL-VQKLSSTTKSAD-HLNGLLRETEATNAI 1588

Query: 432  LIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEK 491
            L+++++  + +++ L  E++  + K +   EY K  L +F  I  K    + +   +   
Sbjct: 1589 LMEQIKLLKSEIRRL--ERNQEREKSAANLEYLKNVLLQF--IFLKPGSERERLLPVINT 1644

Query: 492  NIQLSLEKQQMMEALDQLKSKEHKTQSDMA 521
             +QLS E++  + A+ Q + +     S  A
Sbjct: 1645 MLQLSPEEKGKLAAVAQGEEENASRSSGWA 1674


>gi|217272802 hyaluronan-mediated motility receptor isoform a [Homo
           sapiens]
          Length = 725

 Score = 81.3 bits (199), Expect = 3e-15
 Identities = 109/545 (20%), Positives = 238/545 (43%), Gaps = 60/545 (11%)

Query: 209 KQMKEELQKSHDGEV-ALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLN 267
           K+ K+ L    D  + A   ++++ ++  +  +N K D+  + ++    ++E        
Sbjct: 48  KESKQNLNVDKDTTLPASARKVKSSESKKESQKNDK-DLKILEKEIRVLLQERGAQDRRI 106

Query: 268 EDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKS-EMHRGKKNEKNN-KEIP 325
           +D++++ + ++EA +   L  + ++S  +    ++  +L+++ E+ + K +E  N K + 
Sbjct: 107 QDLETE-LEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLR 165

Query: 326 ITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVK--------QGSIISENEKT 377
           I    +  L+ + R  +       Q   EMK +  Q  L +        +G ++S  ++ 
Sbjct: 166 ILSLELMKLR-NKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEK 224

Query: 378 SKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVE 437
               S TE+    ++Y++     S Q++K  +++     NLK K   ++   QSL + + 
Sbjct: 225 IDEKSETEKL---LEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIV 281

Query: 438 TYEKQLKNLVEEKSTIQSK----LSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNI 493
              KQ+++L  +   ++ +    +++  E+++    E + +  K+ + Q + + L++K +
Sbjct: 282 ILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKEL 341

Query: 494 QLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEK 553
           Q+    QQ  E    L  K    Q +M                          EK + E+
Sbjct: 342 QIDSLLQQEKELSSSLHQKLCSFQEEMV------------------------KEKNLFEE 377

Query: 554 KTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQE 613
           +  Q L E   L  + KE Q E + +K+ E  AK+  E L  + E +K ++  LE +   
Sbjct: 378 ELKQTLDELDKL--QQKEEQAERL-VKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAA 434

Query: 614 STAARQIMERE-------IENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEM 666
            T A  +++ +       +E++     + +     EI++ K E S  +   ++ GK  E 
Sbjct: 435 HTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAED 494

Query: 667 LSKMVMETKTDNQ-----ILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERD 721
           +   ++ T++ NQ     +L  + K   +E    E ++S L +   L     +  E+ R 
Sbjct: 495 VQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRK 554

Query: 722 TLEFE 726
            LE E
Sbjct: 555 QLEDE 559



 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 80/385 (20%), Positives = 177/385 (45%), Gaps = 28/385 (7%)

Query: 372 SENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQS 431
           SE++K S+ N    + + K   ++  L+E     +++ +LE+E   +++++   +    S
Sbjct: 72  SESKKESQKNDKDLKILEK--EIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTS 129

Query: 432 LIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEK 491
           L     T EKQL  L      ++SK S  E  +++ L+     I    +++ +NK   E 
Sbjct: 130 LSANNATLEKQLIELTRTNELLKSKFS--ENGNQKNLR-----ILSLELMKLRNK--RET 180

Query: 492 NIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEML 551
            ++  + KQ+ ME   Q+  +  + +S   I   E   +SIE E +        DEK   
Sbjct: 181 KMRGMMAKQEGMEMKLQVTQRSLE-ESQGKIAQLEGKLVSIEKEKI--------DEKSET 231

Query: 552 EKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTL 611
           EK   + ++E S   +++++ +L+I QL+E     K + + +L + +++++  + L   +
Sbjct: 232 EKLL-EYIEEISCASDQVEKYKLDIAQLEEN---LKEKNDEILSLKQSLEENIVILSKQV 287

Query: 612 QESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMV 671
           ++     Q++E+E E+         EN   E++N K +  + +    ++ ++   +  ++
Sbjct: 288 EDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLL 347

Query: 672 METKTDNQILKEELKKHSQENIK----FENSISRLTEDKILLENYVRSIENERDTLEFEM 727
            + K  +  L ++L    +E +K    FE  + +  ++   L+      E     LE E 
Sbjct: 348 QQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEA 407

Query: 728 RHLQREYLSLSDKICNQHNDPSKTT 752
           +    E   L +K+  +  +  K++
Sbjct: 408 KSRAEELKLLEEKLKGKEAELEKSS 432



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 94/464 (20%), Positives = 202/464 (43%), Gaps = 50/464 (10%)

Query: 257 IKEENLD-GNLNEDIKSKR---ISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMH 312
           +++  LD   L E++K K    +S  ++L + ++   + V   +V    KC+ L K +  
Sbjct: 248 VEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNV----KCQLLEKEKED 303

Query: 313 RGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIIS 372
              +N ++N+ +    +N+          ++ L   ++ K + K+ +    L ++  + S
Sbjct: 304 HVNRNREHNENLNAEMQNLKQ--------KFILEQQEREKLQQKELQIDSLLQQEKELSS 355

Query: 373 ENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSL 432
              +  K+ S  E+ V +    +  LK+++    K+ + E +   L   +K L    +S 
Sbjct: 356 SLHQ--KLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERL---VKQLEEEAKSR 410

Query: 433 IQKVETYEKQLKNLVEE--KSTI---QSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKT 487
            ++++  E++LK    E  KS+    Q+ L   E+Y    ++  + + +++       K 
Sbjct: 411 AEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDS-MVQSLEDVTAQFE----SYKA 465

Query: 488 LEEKNIQ-LSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQD 546
           L    I+ L LE   + E   +        Q  +    + N      +  ++T   L + 
Sbjct: 466 LTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKET 525

Query: 547 EKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQE-TLLQIIETVKDEKL 605
           E   +++ T   L++ + L N+LK+ + +  +  E E   K E+E T  ++ E +   +L
Sbjct: 526 E---IKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRL 582

Query: 606 NLETTLQESTAARQI----MEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIG 661
            L   L   T   Q+     E E + +      A+E  L +I+++ ++   ++N   +I 
Sbjct: 583 -LYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQ-LNKIRDSYAKLLGHQNLKQKI- 639

Query: 662 KECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTED 705
                  K V++ K +N  LK E+ K   +  K + S ++L E+
Sbjct: 640 -------KHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEE 676



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 114/565 (20%), Positives = 217/565 (38%), Gaps = 89/565 (15%)

Query: 41  GCIAESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSK 100
           G +A+ E     +  L+V Q+ LE  Q  ++  L+   +  E ++ +   EKS   E  K
Sbjct: 184 GMMAKQEGM---EMKLQVTQRSLEESQG-KIAQLEGKLVSIEKEKID---EKS---ETEK 233

Query: 101 TLHSVEE-KLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKN 159
            L  +EE   + D V      +    +   E    + +   +L  NI+I   +  D+   
Sbjct: 234 LLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDL--- 290

Query: 160 YNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQM----KEEL 215
                        NV  Q    +L+K K           ENL+    ++KQ     ++E 
Sbjct: 291 -------------NVKCQ----LLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQER 333

Query: 216 QKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRI 275
           +K    E+ + + LQ            K   S +HQ   +F +E   + NL E+   + +
Sbjct: 334 EKLQQKELQIDSLLQ----------QEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTL 383

Query: 276 SELEALVKKLLPFRETVSKFHVHFCRKCKKLS-KSEMHRGKKNEKNNKEIPITGKNITDL 334
            EL+ L +K       V +       + ++L    E  +GK+ E                
Sbjct: 384 DELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAA--------- 434

Query: 335 KFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYL 394
             H++         D     ++D   Q F   +    SE E     NS  ++  AK    
Sbjct: 435 --HTQATLLLQEKYDSMVQSLEDVTAQ-FESYKALTASEIEDLKLENSSLQEKAAKAG-- 489

Query: 395 QNYLKESVQIQKKVMELESEN---------LNLKSKMK--PLIFTTQSLIQKVETYEKQL 443
               K +  +Q +++  ES N         L  KS +K   +   T S +QK+   + QL
Sbjct: 490 ----KNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQL 545

Query: 444 KNLVE----EKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEK 499
           K   E    +    + + ++ E  + E  +E  K    Y  L  + K  + +     +EK
Sbjct: 546 KQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEK 605

Query: 500 QQMMEALDQLKSKEHKTQSDMA-IVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQL 558
           Q ++      + + +K +   A ++ ++N +  I+      +++ ++DE   L+ +  +L
Sbjct: 606 QALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIK------HVVKLKDENSQLKSEVSKL 659

Query: 559 ---LKEKSSLGNELKESQLEIIQLK 580
              L +K     +L+E   +++ +K
Sbjct: 660 RCQLAKKKQSETKLQEELNKVLGIK 684


>gi|217272804 hyaluronan-mediated motility receptor isoform d [Homo
           sapiens]
          Length = 638

 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 102/491 (20%), Positives = 221/491 (45%), Gaps = 37/491 (7%)

Query: 257 IKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKS-EMHRGK 315
           ++E        +D++++ + ++EA +   L  + ++S  +    ++  +L+++ E+ + K
Sbjct: 9   LQERGAQDRRIQDLETE-LEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSK 67

Query: 316 KNEKNN-KEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVK-------- 366
            +E  N K + I    +  L+ + R  +       Q   EMK +  Q  L +        
Sbjct: 68  FSENGNQKNLRILSLELMKLR-NKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQL 126

Query: 367 QGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLI 426
           +G ++S  ++     S TE+    ++Y++     S Q++K  +++     NLK K   ++
Sbjct: 127 EGKLVSIEKEKIDEKSETEKL---LEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEIL 183

Query: 427 FTTQSLIQKVETYEKQLKNLVEEKSTIQSK----LSKTEEYSKECLKEFKKIISKYNVLQ 482
              QSL + +    KQ+++L  +   ++ +    +++  E+++    E + +  K+ + Q
Sbjct: 184 SLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQ 243

Query: 483 GQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNIL 542
            + + L++K +Q+    QQ  E    L  K    Q +M     E N    E++     + 
Sbjct: 244 QEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMV---KEKNLFEEELKQTLDELD 300

Query: 543 LIQDEKEMLEKKTHQLLKEKSSLGNELK--ESQLEIIQLK-EKERLAKTEQETLLQIIET 599
            +Q ++E  E+   QL +E  S   ELK  E +L+  + + EK   A T+   LLQ  E 
Sbjct: 301 KLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQ--EK 358

Query: 600 VKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSE 659
                 +LE    +  + + +   EIE+++   S+ +E   +  KNA+      ++ +  
Sbjct: 359 YDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAED----VQHQILA 414

Query: 660 IGKECEMLSKMVMETKTDNQILKEELKKHS----QENIKFENSISRLTED--KILLENYV 713
                +   +M+++ +T + + + E+K+ +    Q+    +N + +  ED  K L +   
Sbjct: 415 TESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEG 474

Query: 714 RSIENERDTLE 724
           R  E E  T E
Sbjct: 475 RKAEKENTTAE 485



 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 74/359 (20%), Positives = 164/359 (45%), Gaps = 26/359 (7%)

Query: 398 LKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKL 457
           L+E     +++ +LE+E   +++++   +    SL     T EKQL  L      ++SK 
Sbjct: 9   LQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKF 68

Query: 458 SKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQ 517
           S  E  +++ L+     I    +++ +NK   E  ++  + KQ+ ME   Q+  +  + +
Sbjct: 69  S--ENGNQKNLR-----ILSLELMKLRNK--RETKMRGMMAKQEGMEMKLQVTQRSLE-E 118

Query: 518 SDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEII 577
           S   I   E   +SIE E +        DEK   EK   + ++E S   +++++ +L+I 
Sbjct: 119 SQGKIAQLEGKLVSIEKEKI--------DEKSETEKLL-EYIEEISCASDQVEKYKLDIA 169

Query: 578 QLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEE 637
           QL+E     K + + +L + +++++  + L   +++     Q++E+E E+         E
Sbjct: 170 QLEEN---LKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNE 226

Query: 638 NFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIK--- 694
           N   E++N K +  + +    ++ ++   +  ++ + K  +  L ++L    +E +K   
Sbjct: 227 NLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKN 286

Query: 695 -FENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTT 752
            FE  + +  ++   L+      E     LE E +    E   L +K+  +  +  K++
Sbjct: 287 LFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSS 345



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 114/565 (20%), Positives = 217/565 (38%), Gaps = 89/565 (15%)

Query: 41  GCIAESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSK 100
           G +A+ E     +  L+V Q+ LE  Q  ++  L+   +  E ++ +   EKS   E  K
Sbjct: 97  GMMAKQEGM---EMKLQVTQRSLEESQG-KIAQLEGKLVSIEKEKID---EKS---ETEK 146

Query: 101 TLHSVEE-KLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKN 159
            L  +EE   + D V      +    +   E    + +   +L  NI+I   +  D+   
Sbjct: 147 LLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDL--- 203

Query: 160 YNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQM----KEEL 215
                        NV  Q    +L+K K           ENL+    ++KQ     ++E 
Sbjct: 204 -------------NVKCQ----LLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQER 246

Query: 216 QKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRI 275
           +K    E+ + + LQ            K   S +HQ   +F +E   + NL E+   + +
Sbjct: 247 EKLQQKELQIDSLLQ----------QEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTL 296

Query: 276 SELEALVKKLLPFRETVSKFHVHFCRKCKKLS-KSEMHRGKKNEKNNKEIPITGKNITDL 334
            EL+ L +K       V +       + ++L    E  +GK+ E                
Sbjct: 297 DELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAA--------- 347

Query: 335 KFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYL 394
             H++         D     ++D   Q F   +    SE E     NS  ++  AK    
Sbjct: 348 --HTQATLLLQEKYDSMVQSLEDVTAQ-FESYKALTASEIEDLKLENSSLQEKAAKAG-- 402

Query: 395 QNYLKESVQIQKKVMELESEN---------LNLKSKMK--PLIFTTQSLIQKVETYEKQL 443
               K +  +Q +++  ES N         L  KS +K   +   T S +QK+   + QL
Sbjct: 403 ----KNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQL 458

Query: 444 KNLVE----EKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEK 499
           K   E    +    + + ++ E  + E  +E  K    Y  L  + K  + +     +EK
Sbjct: 459 KQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEK 518

Query: 500 QQMMEALDQLKSKEHKTQSDMA-IVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQL 558
           Q ++      + + +K +   A ++ ++N +  I+      +++ ++DE   L+ +  +L
Sbjct: 519 QALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIK------HVVKLKDENSQLKSEVSKL 572

Query: 559 ---LKEKSSLGNELKESQLEIIQLK 580
              L +K     +L+E   +++ +K
Sbjct: 573 RCQLAKKKQSETKLQEELNKVLGIK 597


>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
          Length = 2479

 Score = 80.5 bits (197), Expect = 6e-15
 Identities = 163/809 (20%), Positives = 333/809 (41%), Gaps = 127/809 (15%)

Query: 6    QHREEDEVDSVLLSASKI---LNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQQ 62
            Q   EDEV  V      +   L+ S+  KES C  +E     E+ N   P + ++ L ++
Sbjct: 1673 QENHEDEVKKVKAEVEDLKYLLDQSQ--KESQCLKSELQAQKEA-NSRAPTTTMRNLVER 1729

Query: 63   LESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVN 122
            L+S  AL+           E Q++ LS           T  + E  +S  S      +V 
Sbjct: 1730 LKSQLALK-----------EKQQKALSRALLE-LRAEMTAAAEERIISATSQKEAHLNVQ 1777

Query: 123  VPSQIHSEDTLTLRTSTDNLSSNII-----IHPSEN-----SDILKNYNNFYRFLPTAPP 172
               QI    T  L+T  ++L+ N++     +  S+N     +D L + NN  +    A  
Sbjct: 1778 ---QIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYN 1834

Query: 173  NVMSQADTVIL--DKSKITVPFLKHGF-----CENLDDICHSIKQMKEELQKSHDGEVAL 225
             ++ + + +    D+ K  +  L  G       +N   +   +++  ++L+   +G+V  
Sbjct: 1835 KILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKV-- 1892

Query: 226  TNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKL 285
                + +   P   +N K ++    + K    K E +   L E     +  E+  L K+L
Sbjct: 1893 ----EEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKE-----KEGEVFTLTKQL 1943

Query: 286  LPFRETVSKFHVHFCRKCKKLSKSEMH-------RGKKNEKNNKEIPITGKNITD----L 334
               ++  +K         +KL  + M        R  ++EK  +E+     ++ +    +
Sbjct: 1944 NTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYM 2003

Query: 335  KFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYL 394
            + H  +PR      D    ++  + R  +L ++   +   EK    ++ ++  ++ I+  
Sbjct: 2004 RAHQALPR------DSVVEDLHLQNR--YLQEK---LHALEKQFSKDTYSKPSISGIES- 2051

Query: 395  QNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQ 454
             ++ +   ++QK+ ++L SEN+ LK +++        L  +V   ++  + L +EK+ +Q
Sbjct: 2052 DDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQ 2111

Query: 455  SKLS--KTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSK 512
             KL   +    S + + E +K I       G  K + EK   +  E +Q+ +A   L S+
Sbjct: 2112 RKLGHVRGSGRSGKTIPELEKTI-------GLMKKVVEK---VQRENEQLKKASGILTSE 2161

Query: 513  EHKTQSDMAIVNNENNRMSIEMEAMKTNI-LLIQDEKEMLEKKTHQLLKEKSSLGNELK- 570
            +      MA +  EN ++  E+E +K ++   +    E   K T +++ E   L  ELK 
Sbjct: 2162 K------MANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKK 2215

Query: 571  -----------ESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQ 619
                       ++ LEI+  K   +L +T +   LQ  E+   +    ++   +S    +
Sbjct: 2216 ETDAAEKLRIAKNNLEILNEKMTVQLEETGKR--LQFAESRGPQLEGADSKSWKSIVVTR 2273

Query: 620  IMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEM---LSKMVMETKT 676
            + E +++ ++T     +   + ++K    EA+  +  +++  ++ E    + K V E   
Sbjct: 2274 MYETKLKELET-DIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAE 2332

Query: 677  DNQILKEELKK----------------HSQENIKFENSISRLTEDKILLENYVRSIENER 720
              Q LK EL+                 H  E  K ++       D   L+  ++ +E + 
Sbjct: 2333 TEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQL 2392

Query: 721  DTLEFEMRHLQREYLSLSDKICNQHNDPS 749
               + E +HL+ E   L  ++  ++ DPS
Sbjct: 2393 KMSDLEKQHLKEEIKKLKKEL--ENFDPS 2419



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 103/548 (18%), Positives = 232/548 (42%), Gaps = 93/548 (16%)

Query: 227 NELQTLQTDPD-------VHRNGKYDMSPIHQDKMNFIKEENLDG--NLNEDIKSKRISE 277
           N  + ++ DPD       +  N    +S +  +++   K+EN+     + + +   +  E
Sbjct: 6   NWKEIMKVDPDDLPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQE 65

Query: 278 LEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFH 337
           +E  ++++    E  +KF      K  KL            +N  E+        D +F 
Sbjct: 66  VELALEEVEKAGEEQAKFENQLKTKVMKL------------ENELEMAQQSAGGRDTRFL 113

Query: 338 SRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNY 397
                     L+Q   E++D E+            E EK  KVN   EQ   + +  +N 
Sbjct: 114 RNEICQLEKQLEQKDRELEDMEK------------ELEKEKKVN---EQLALRNEEAEN- 157

Query: 398 LKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVE-------EK 450
                    +  +L  EN  LK K        + L Q +  Y+KQ+ +  E       E 
Sbjct: 158 ---------ENSKLRRENKRLKKK-------NEQLCQDIIDYQKQIDSQKETLLSRRGED 201

Query: 451 STIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSL-EKQQMMEALDQL 509
           S  +S+LSK      + L E + +      ++ QN+ +  KN++ S+ E ++M +  +++
Sbjct: 202 SDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEM-RKNLEESVQEMEKMTDEYNRM 260

Query: 510 KSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKE-----MLEKKTHQLLKEKSS 564
           K+  H+T + +  +  EN+   ++++ + T++L  ++E++      +  K  +     SS
Sbjct: 261 KAIVHQTDNVIDQLKKENDHYQLQVQEL-TDLLKSKNEEDDPIMVAVNAKVEEWKLILSS 319

Query: 565 LGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMERE 624
             +E+ E Q  +  L+EK + A+ + +         K   + L+  +QE  +  +++  +
Sbjct: 320 KDDEIIEYQQMLHNLREKLKNAQLDAD---------KSNVMALQQGIQERDSQIKMLTEQ 370

Query: 625 IENIQTYQSTAEEN--FLQEIKNA----KSEASIYKNSLSEIGKECEMLSKMVMETKTDN 678
           +E    Y    E+N   ++++KN     K  +++ + +  +I    ++L +   E +   
Sbjct: 371 VEQ---YTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTA 427

Query: 679 QILKEELKKHSQENIK-------FENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQ 731
           ++ + + ++  +E ++       +E+ +  L +  + ++N    I+     +E   + + 
Sbjct: 428 ELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEIN 487

Query: 732 REYLSLSD 739
           +  L +SD
Sbjct: 488 KLELKISD 495



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 98/478 (20%), Positives = 211/478 (44%), Gaps = 85/478 (17%)

Query: 307  SKSEMHRGKKNEKNNKEIPITGKN--ITDLK----------FHSRVPRYTLSFLDQTKHE 354
            +  + HR  +N+    E+ + G    I+ LK          +H ++    L  L   +  
Sbjct: 1306 NSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNREL 1365

Query: 355  MKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQN----YLKESVQIQKKVM- 409
            +KDKE   +L    +IISE E+T  ++S+ E+ V + ++ +     + +  V +++++  
Sbjct: 1366 VKDKEEIKYL---NNIISEYERT--ISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDI 1420

Query: 410  --ELESENLNLKSKMK--------PLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSK 459
                ++E LN   K +        P +     L   +   ++ ++ ++E ++T +S   K
Sbjct: 1421 FDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEK 1480

Query: 460  TEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQL--SLEKQQMMEALDQLKSKEHKTQ 517
             +E      KE    +++ N+L  ++K + E  ++L  + E+++++  L + K  E K+ 
Sbjct: 1481 LKE------KESALRLAEQNILS-RDKVINELRLRLPATAEREKLIAELGR-KEMEPKSH 1532

Query: 518  SDMAIVN----NENNRMSIEMEAMKTNILLIQ----DEKEMLEKKTHQL--------LKE 561
              + I +    N   R++ + E +K    L++    +++E+++K    L        L+ 
Sbjct: 1533 HTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQA 1592

Query: 562  KSSLG-------NELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQES 614
             SSL        + +K+S   +   K   RLA+ EQ T+ +  +++    + L+   Q+ 
Sbjct: 1593 DSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQ-TVAEQDDSLSSLLVKLKKVSQDL 1651

Query: 615  TAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMET 674
               R+I E +++  +  +   +EN   E+K  K+E               E L  ++ ++
Sbjct: 1652 ERQREITELKVKEFENIKLQLQENHEDEVKKVKAEV--------------EDLKYLLDQS 1697

Query: 675  KTDNQILKEELKKHSQENIK-----FENSISRLTEDKILLENYVRSIENERDTLEFEM 727
            + ++Q LK EL+   + N +       N + RL     L E   +++      L  EM
Sbjct: 1698 QKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEM 1755



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 145/775 (18%), Positives = 297/775 (38%), Gaps = 145/775 (18%)

Query: 44  AESENQIQPQSALKVLQQQLESFQAL--RMQTLQNVSMPTENQEENLSMEKSHHFEDSKT 101
           A  + ++Q Q   K L++ ++  + +      ++ +   T+N  + L  E  H+      
Sbjct: 228 ANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHY------ 281

Query: 102 LHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYN 161
                 +L    +  L +S N       ED   +      +    +I  S++ +I++   
Sbjct: 282 ------QLQVQELTDLLKSKN------EEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQ 329

Query: 162 NFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDI---CHSIKQMKEELQKS 218
             +        N+  +     LD  K  V  L+ G  E    I      ++Q  +E++K+
Sbjct: 330 MLH--------NLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKN 381

Query: 219 HDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISEL 278
                 L NELQ  +    + +     +           KE      L E    ++  EL
Sbjct: 382 TCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKEL 441

Query: 279 EALVKKLLPFRETVSKFH--VHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKF 336
              +K+L  +   V      V   + CK   K            ++EI I  K I  L+ 
Sbjct: 442 VEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIR----------DREIEILTKEINKLEL 491

Query: 337 HSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQN 396
                     FLD+ +   +    +P                 +  +TE   +K    Q 
Sbjct: 492 KIS------DFLDENEALRERVGLEP---------------KTMIDLTEFRNSKHLKQQQ 530

Query: 397 YLKESVQIQKKVMELESENLNLKSKMKPLI-----------FTTQSL-----IQKVETYE 440
           Y  E+  + K++  LE E L+LK K++ +             TT+ L     I + +   
Sbjct: 531 YRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRIS 590

Query: 441 KQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVL---QGQNKTLEEKNIQLSL 497
           ++  +L+  K+  +++ SK E  S+E +++ + +     V+   Q + K L E+N QL  
Sbjct: 591 ERKLDLLSLKNMSEAQ-SKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEE 649

Query: 498 EKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEA------------MKTNILLIQ 545
             +++++A+ +++        + +++     R+   +E+            +K  +  + 
Sbjct: 650 GMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLT 709

Query: 546 DEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAK------------------ 587
              E L ++  +  KE  +   +L ++ L+I  L+++  L +                  
Sbjct: 710 GRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGI 769

Query: 588 ---------TEQETLLQIIETV--KDEKL-NLETTLQESTAARQIMEREIENIQTYQSTA 635
                    ++ E L+ +++ +  K++KL NLE +L++         R+   I+  QS  
Sbjct: 770 APSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLED-------YNRKFAVIRHQQSLL 822

Query: 636 EENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQIL------KEELKKHS 689
            + +L E +  K+E+   K    E  K  + + +  ++ K  N +L       +E+KK  
Sbjct: 823 YKEYLSEKETWKTESKTIK---EEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKIL 879

Query: 690 QENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQ 744
            EN +    +     +K L+  Y   +E ER  L  E    + E LS+  ++C +
Sbjct: 880 AENSRKITVLQ--VNEKSLIRQYTTLVELERQ-LRKENEKQKNELLSMEAEVCEK 931



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 95/437 (21%), Positives = 190/437 (43%), Gaps = 56/437 (12%)

Query: 300  CRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDK- 358
            C++ ++L K  +    +N +   ++    K++  LK   R  +    FL + K E++ K 
Sbjct: 2055 CQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKL 2114

Query: 359  ERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQI--QKKVMELESENL 416
                   + G  I E EKT     + ++ V K+Q     LK++  I   +K+  +E EN 
Sbjct: 2115 GHVRGSGRSGKTIPELEKTI---GLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENE 2171

Query: 417  NLKSKMKPL-IFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKII 475
             LK++++ L       L    E+  K  + ++ E   ++ +L K E  + E L+  K  +
Sbjct: 2172 KLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKK-ETDAAEKLRIAKNNL 2230

Query: 476  SKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMS-IEM 534
               N  +     LEE   +L   + +      QL+  + K+   + +      ++  +E 
Sbjct: 2231 EILN--EKMTVQLEETGKRLQFAESRG----PQLEGADSKSWKSIVVTRMYETKLKELET 2284

Query: 535  EAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQ-----------LKEKE 583
            +  K N   I D K+++++ T +  ++K +  NE  E Q++I++           LK + 
Sbjct: 2285 DIAKKN-QSITDLKQLVKEATER--EQKVNKYNEDLEQQIKILKHVPEGAETEQGLKREL 2341

Query: 584  RLAKT-------EQETLLQIIETVKD---------------EKL-NLETTLQESTAARQI 620
            ++ +        E+  L+  IE  KD               EK+ +LET L+ S   +Q 
Sbjct: 2342 QVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQH 2401

Query: 621  MEREIENIQTYQSTAEENFLQEIKNAK--SEASIYKNSLSEIGKECEMLSKMVMETKTDN 678
            ++ EI+ ++      + +F +EI++ K   +  + KN L E  ++ + LS+ +    T  
Sbjct: 2402 LKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLE--EKVKKLSEQLGVELTSP 2459

Query: 679  QILKEELKKHSQENIKF 695
                EE +   +  + F
Sbjct: 2460 VAASEEFEDEEESPVNF 2476



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 120/577 (20%), Positives = 246/577 (42%), Gaps = 68/577 (11%)

Query: 215  LQKSHDGEVALTN-ELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSK 273
            LQK  D  V+L+  EL   Q +       KY    + +D M   +  NL+    E+I  K
Sbjct: 949  LQKVVDNSVSLSELELANKQYN---ELTAKY-RDILQKDNMLVQRTSNLEHLECENISLK 1004

Query: 274  RISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITD 333
               ++E++ K+L   +E +      + ++ K  ++S M + KK+  N+  + I+ K IT 
Sbjct: 1005 E--QVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSIS-KKITM 1061

Query: 334  LKFHSRVPR----YTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVA 389
            L+      R    +     +  +  +K  E + F ++         K +++  +      
Sbjct: 1062 LEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELET--------KFAELTKINLDAQK 1113

Query: 390  KIQYLQNYLKESVQI------QKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQL 443
              Q L++ L +SV        +++++ELE   + LK ++  L   +    ++VE    Q 
Sbjct: 1114 VEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQ 1173

Query: 444  KNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISK---YNVLQGQNKTLEEKNIQLSLEKQ 500
            ++  +E  +++ +L   +  S E     K +I+K   +NV    ++      ++    K 
Sbjct: 1174 QSRDKEVESLRMQLLDYQAQSDE-----KSLIAKLHQHNVSLQLSEATALGKLESITSKL 1228

Query: 501  QMMEALD-QLKSKEHKTQSDMAIVNNENN------RMSIEMEAMKTNILLIQDEKEMLEK 553
            Q MEA + +L+ K  + +  +     E        R +I+    + +  L   ++E   K
Sbjct: 1229 QKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSK 1288

Query: 554  KTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEK-----LNL- 607
               QL  +K  +  E+K SQ E   ++ K    + + + L ++I T+KD K     +N  
Sbjct: 1289 TMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWH 1348

Query: 608  ----ETTLQESTAARQIMEREIE------NIQTYQ---STAEENFLQEIKNAKSEASIYK 654
                E  LQE    R++++ + E       I  Y+   S+ EE  +Q+ K  +     + 
Sbjct: 1349 MKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWD 1408

Query: 655  NSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFEN----SISRLTED-KILL 709
                ++ ++ ++  +   E     Q  +E        ++   N    ++ ++ E+ +I+L
Sbjct: 1409 QREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIIL 1468

Query: 710  ENYV--RSIENERDTLEFEMRHLQREYLSLSDKICNQ 744
            E     +S+E +    E  +R  ++  LS  DK+ N+
Sbjct: 1469 ETRATCKSLEEKLKEKESALRLAEQNILS-RDKVINE 1504



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 63/304 (20%), Positives = 132/304 (43%), Gaps = 32/304 (10%)

Query: 457 LSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKT 516
           L + EE +   L    K+       + Q   +    I  SL K +  E    L+  E K 
Sbjct: 18  LPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVE-KA 76

Query: 517 QSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKK-----THQLLKEKSSLGNELKE 571
             + A   N+          +KT ++ +++E EM ++      T  L  E   L  +L++
Sbjct: 77  GEEQAKFENQ----------LKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQ 126

Query: 572 SQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTY 631
              E+  ++++    K   E L    E  ++E   L    +E+   ++  E+  ++I  Y
Sbjct: 127 KDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLR---RENKRLKKKNEQLCQDIIDY 183

Query: 632 QSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKM-----VMETKTDNQILKEELK 686
           Q   +    + + + + E S Y++ LS+  K  E++  +     + E     ++  +E++
Sbjct: 184 QKQIDSQ-KETLLSRRGEDSDYRSQLSK--KNYELIQYLDEIQTLTEANEKIEVQNQEMR 240

Query: 687 KHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSD--KICNQ 744
           K+ +E+++    + ++T++   ++  V   +N  D L+ E  H Q +   L+D  K  N+
Sbjct: 241 KNLEESVQ---EMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNE 297

Query: 745 HNDP 748
            +DP
Sbjct: 298 EDDP 301


>gi|31982906 cingulin-like 1 [Homo sapiens]
          Length = 1302

 Score = 80.5 bits (197), Expect = 6e-15
 Identities = 88/402 (21%), Positives = 174/402 (43%), Gaps = 33/402 (8%)

Query: 348 LDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKK 407
           L Q  +E   K+     +K+GS  +++    KVN V E    KIQ L++    S Q   +
Sbjct: 546 LTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFE----KIQTLKSRAAGSAQGNNQ 601

Query: 408 VMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKEC 467
                SE  +L  +   L      L ++++   K  +N+ EE+  +++ L +      E 
Sbjct: 602 ACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEK 661

Query: 468 LKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQ----MMEALDQLKSKEHKTQSDMAIV 523
           ++E   +  +    +G+ +   E+  Q+ +E++Q    + +  DQL     +  S     
Sbjct: 662 VEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSE 721

Query: 524 NNENNRMSIEMEAMKTNI--LLI--QDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQL 579
           + E   +  E+   K ++  LLI  ++++++L K+  +L   K +L  E+     E+ +L
Sbjct: 722 DREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKL 781

Query: 580 KEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENF 639
           KE+          L  + E+V++   N+E     S  + Q        ++  Q   EEN 
Sbjct: 782 KEQY------DAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQ---EEN- 831

Query: 640 LQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSI 699
             E    +SE         E+ +    L + + + K D    KE LKK+  E  + E ++
Sbjct: 832 --EKLQGRSE---------ELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEAL 880

Query: 700 SRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKI 741
               +++    +  R++ENE +  +  +    +E   LS+K+
Sbjct: 881 VHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKL 922



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 134/762 (17%), Positives = 317/762 (41%), Gaps = 97/762 (12%)

Query: 51   QPQSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLS 110
            QP    KVL+   E  Q   +    ++   ++ +EE  +   +   ++  T  S +    
Sbjct: 463  QPNIDGKVLET--EGSQESTVIRAPSLGAQSKKEEEVKTATATLMLQNRATATSPDSGAK 520

Query: 111  GDSVNSLPQSVNV---PSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFL 167
              SV + P + N    P  +  +  LT +T+ +     +  +  E S             
Sbjct: 521  KISVKTFPSASNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEGS------------- 567

Query: 168  PTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTN 227
             T   +   +   ++ +K + T+     G  +  +  C+S  ++K+ L++     + +  
Sbjct: 568  -TDNDDATKRKVNLVFEKIQ-TLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAE 625

Query: 228  ELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLP 287
              + LQ +    +N K +   +  +      + N     N  ++ +R+ E E  ++K L 
Sbjct: 626  LQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQ-QRLEESEGELRKNLE 684

Query: 288  FRETVSKFHVHFCRKCKKLSK--SEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTL 345
                V         + + L    SEMH    + K +++    G  I +L    +  +  L
Sbjct: 685  ELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDRE-KGALIEELLQAKQDLQDLL 743

Query: 346  SFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQ-- 403
               ++ +  ++ +ER+   +K       +    +++ + EQ  A++Q L+  ++E+ +  
Sbjct: 744  IAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNV 803

Query: 404  ----------------IQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLV 447
                             + +V  L+ EN  L+ + + L      L +++E  +       
Sbjct: 804  EVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAK 863

Query: 448  EEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEAL- 506
            E     + ++ + EE      KE K+ +S    L+ + +  +    Q + E++Q+ E L 
Sbjct: 864  ETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLK 923

Query: 507  ------DQLKSKEHKTQSDMAIVNNENNRMSIEM----EAMKTNILLIQDEKEMLEKKTH 556
                  +QL+  +++ +++   +     ++  EM    EA +T+ L +Q++ +  ++K  
Sbjct: 924  EESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNR 983

Query: 557  QLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTA 616
            + L E   +  +LKE  LE     EK RL   + +  ++++E   +E  + +    E+  
Sbjct: 984  RELAE---MQRQLKEKTLEA----EKSRLTAMKMQDEMRLME---EELRDYQRAQDEALT 1033

Query: 617  ARQIMEREIENIQTYQSTAEENFLQE----IKNAKSEASIYKNSLSEIGKECEMLSKMVM 672
             RQ++E+ +++++ Y+  A+ +   +    +K  + + S  +  L E     ++LS+ + 
Sbjct: 1034 KRQLLEQTLKDLE-YELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERIS 1092

Query: 673  ETKTDNQILKEEL--KKHSQENIKFEN-SISRLTED---KIL------------------ 708
             ++   + L+ EL  ++ ++++++ +  S+ R  +D   +I+                  
Sbjct: 1093 RSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQME 1152

Query: 709  -----LENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQH 745
                 LE+ + S E +R  L+   R L+R+   L  ++ ++H
Sbjct: 1153 ARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEH 1194



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 152/793 (19%), Positives = 317/793 (39%), Gaps = 104/793 (13%)

Query: 21   SKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMP 80
            S+   S++G  ++  S +E   + E ++++  + A   LQ+QL+    L ++  QN+   
Sbjct: 590  SRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVA--ELQRQLQ----LEVKNQQNIKEE 643

Query: 81   TENQEENLSMEKSHH---FEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRT 137
             E    NL   +S H    E++ TL    E+  G+   +L +   V  +           
Sbjct: 644  RERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQ-------- 695

Query: 138  STDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGF 197
                       H +E  D+    +  +  L +A  +   +   +I +  +          
Sbjct: 696  -----------HQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAK-------- 736

Query: 198  CENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFI 257
             ++L D+  + ++ ++ L+K      AL   L             K ++S  H  +M+ +
Sbjct: 737  -QDLQDLLIAKEEQEDLLRKRERELTALKGAL-------------KEEVSS-HDQEMDKL 781

Query: 258  KEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKN 317
            KE+  D  L    +S  + E    V+ L     T  +       + K L +       ++
Sbjct: 782  KEQ-YDAELQALRES--VEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRS 838

Query: 318  EKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKT 377
            E+  + +    + I DLK      + TL      K+E + ++ +  LV       E E  
Sbjct: 839  EELERRVAQLQRQIEDLKGDEAKAKETLK-----KYEGEIRQLEEALVHARK--EEKEAV 891

Query: 378  SKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVE 437
            S   ++  +  A    L    +E  Q+ +K+ E   +   L+     +      L + +E
Sbjct: 892  SARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIE 951

Query: 438  TYEKQLKNLVEEKST----IQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNI 493
              +K++ ++VE   T    +Q++L + +E ++  L E ++        Q + KTLE +  
Sbjct: 952  KLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQR--------QLKEKTLEAEKS 1003

Query: 494  QLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEK 553
            +L+  K Q    L + + ++++   D A+      R  +E          ++D +  LE 
Sbjct: 1004 RLTAMKMQDEMRLMEEELRDYQRAQDEAL----TKRQLLEQ--------TLKDLEYELEA 1051

Query: 554  KTHQLLKEKSSLGNEL--KESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTL 611
            K+H L  ++S L  ++  K SQLE ++L+E+    +   + L + I   +++   L   L
Sbjct: 1052 KSH-LKDDRSRLVKQMEDKVSQLE-MELEEE----RNNSDLLSERISRSREQMEQLRNEL 1105

Query: 612  QESTAARQIMEREIENIQTYQSTAEENFLQ---EIKNAKSEASIYKNS-LSEIGKECEML 667
             +  AARQ +E +  +++      +   +      +++K    +   + ++E+    E  
Sbjct: 1106 LQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESE 1165

Query: 668  SKMVMETKTDNQILKEELK----KHSQENIKFENSISRLTEDKILLENYVRSIENERDTL 723
             +     +  N+ L+ ++K    +   E++   +   +L+     ++  V   E E D L
Sbjct: 1166 ERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRL 1225

Query: 724  EFEMRHLQR---EYLSLSDKICNQHNDPSKTTYISRREKFHFDNYTHEDTSSPQSRPLAS 780
            E   + LQR   E + +++ +  Q N   K   + +      D+   +D  S     L  
Sbjct: 1226 ESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLPSKVLDDMDDDDDLSTDGGSLYE 1285

Query: 781  DLKGYFKVKDRTL 793
                Y   KD T+
Sbjct: 1286 APVSYTFSKDSTV 1298



 Score = 37.0 bits (84), Expect = 0.072
 Identities = 38/191 (19%), Positives = 77/191 (40%), Gaps = 20/191 (10%)

Query: 581 EKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEE--- 637
           ++E   +T +ET  QI+     E      +     A ++ +    E IQT +S A     
Sbjct: 543 QQELTQQTNEETAKQILYNYLKEG-----STDNDDATKRKVNLVFEKIQTLKSRAAGSAQ 597

Query: 638 ------NFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILK---EELKKH 688
                 N   E+K+   + S     ++E+ ++ ++  K     K + + ++   EEL+  
Sbjct: 598 GNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQ 657

Query: 689 SQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDP 748
             E ++  +++ +  E+    E  +R    E   ++ E    Q E   L D++   H++ 
Sbjct: 658 HNEKVEENSTLQQRLEES---EGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDEL 714

Query: 749 SKTTYISRREK 759
                   REK
Sbjct: 715 DSAKRSEDREK 725



 Score = 32.7 bits (73), Expect = 1.4
 Identities = 69/352 (19%), Positives = 144/352 (40%), Gaps = 40/352 (11%)

Query: 404 IQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEY 463
           I  KV+E E    +   +  P +       ++V+T    L  +++ ++T  S  S  ++ 
Sbjct: 466 IDGKVLETEGSQESTVIRA-PSLGAQSKKEEEVKTATATL--MLQNRATATSPDSGAKKI 522

Query: 464 SKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIV 523
           S +         +  ++L+GQ +  ++ N + +  KQ +   L     KE  T +D A  
Sbjct: 523 SVKTFPSASNTQATPDLLKGQQELTQQTNEETA--KQILYNYL-----KEGSTDNDDA-T 574

Query: 524 NNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQ---LLKEKSSLGNELKESQLEIIQLK 580
             + N +  +++ +K+               T +   LL++KS L  E+ E Q ++ QL+
Sbjct: 575 KRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQL-QLE 633

Query: 581 EKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEEN-- 638
            K +             + +K+E+  +   L+E    R     ++E   T Q   EE+  
Sbjct: 634 VKNQ-------------QNIKEERERMRANLEE---LRSQHNEKVEENSTLQQRLEESEG 677

Query: 639 ----FLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIK 694
                L+E+   K E   ++  + ++    + LS+M  E  +  +    E     +E ++
Sbjct: 678 ELRKNLEELFQVKMEREQHQTEIRDLQ---DQLSEMHDELDSAKRSEDREKGALIEELLQ 734

Query: 695 FENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHN 746
            +  +  L   K   E+ +R  E E   L+  ++     +    DK+  Q++
Sbjct: 735 AKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYD 786


>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
          Length = 1780

 Score = 80.5 bits (197), Expect = 6e-15
 Identities = 124/598 (20%), Positives = 248/598 (41%), Gaps = 85/598 (14%)

Query: 177  QADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQT----- 231
            Q +  + +K  +T+         N D     +   K + Q+  +  + L+NE++T     
Sbjct: 876  QQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSI 935

Query: 232  ----------------LQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNL-----NEDI 270
                            L+T   V +    D+  + +D  N  +E+NL         N+ +
Sbjct: 936  TNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNL-RDLSNGSEEDNLPNTQLDLLGNDYL 994

Query: 271  KSKRISELEALVKKLLPFRETVSKFHVHF------CRKCKKLSKSEMHRGKKNEKNNKEI 324
             SK++ E         P RE  + FH         C++  K S  + H+ ++ E+  +++
Sbjct: 995  VSKQVKEYRIQE----PNRE--NSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKL 1048

Query: 325  PITGKNITDLKFHSRVPRYTLSFLDQTKHEMKD---KERQPFLVKQGSIISENEKTS--K 379
                K   D            + L + +H+ +D   KE++  + +    + E   T   +
Sbjct: 1049 QAEVKGYKDEN----------NRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQ 1098

Query: 380  VNSVTEQCVAKIQYLQNYL--KESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVE 437
            +  V E   A  +  Q     K  ++  + ++E +    +  +K++  I   +S+I K+E
Sbjct: 1099 IQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLE 1158

Query: 438  TYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSL 497
                  +NL E +  +Q  +  T++ + + LK  ++I    N LQ     L+ K  +   
Sbjct: 1159 ------RNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEET 1212

Query: 498  EKQQMMEALDQLKSKEHKTQS----------DMAIVNNENNRMSIEMEAMKTNILLIQDE 547
             +Q+  +  ++L +   +TQ+          D A +  +      +++ ++  + +++DE
Sbjct: 1213 NRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDE 1272

Query: 548  KEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNL 607
             ++L  K ++L K+K+    EL   Q  I QLKE+    K E E + Q     KD  LN+
Sbjct: 1273 DKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVE-EAIQQYERACKD--LNV 1329

Query: 608  ETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEML 667
            +  + E    R  +E E E  Q  Q    E  L+E++   +E   +K   +++  +    
Sbjct: 1330 KEKIIED--MRMTLE-EQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQR 1386

Query: 668  SKMVMETKTD----NQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERD 721
            S    E  TD       L++EL++  Q   K+     +  E+K++L    +  EN R+
Sbjct: 1387 SNKEHENNTDVLGKLTNLQDELQESEQ---KYNADRKKWLEEKMMLITQAKEAENIRN 1441



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 116/572 (20%), Positives = 236/572 (41%), Gaps = 48/572 (8%)

Query: 204  ICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLD 263
            IC+   ++ ++ +     E    NE +  Q +P   +   +  S I +D+    K E + 
Sbjct: 772  ICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQK---KSEEVR 828

Query: 264  GNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKE 323
             N+ E I+  R+  L+   + L  F  T+     +   +  +L+K  +H  ++   + K+
Sbjct: 829  PNIAE-IEDIRV--LQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKK 885

Query: 324  IPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSV 383
                 K +  ++ +     Y ++  +    + K++E++  ++K  + I E    S  N+V
Sbjct: 886  NLTLSKEVQQIQSN-----YDIAIAELHVQKSKNQEQEEKIMKLSNEI-ETATRSITNNV 939

Query: 384  TEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQL 443
            ++  +   +  +    +SV     +  L   +L+  S+   L  T   L+       KQ+
Sbjct: 940  SQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQV 999

Query: 444  KNL-VEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQM 502
            K   ++E +   S  S  E   +EC    K+I+   +    Q + LE++  +L  E +  
Sbjct: 1000 KEYRIQEPNRENSFHSSIEAIWEEC----KEIVKASSKKSHQIEELEQQIEKLQAEVKGY 1055

Query: 503  MEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEK 562
             +  ++LK KEHK Q D+                +K    LIQ  KE L++K   L  + 
Sbjct: 1056 KDENNRLKEKEHKNQDDL----------------LKEKETLIQQLKEELQEKNVTLDVQI 1099

Query: 563  SSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIME 622
              +  E K +  E+ Q     +    E ET+L+  +        LE  + E  +    +E
Sbjct: 1100 QHVV-EGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLE 1158

Query: 623  REIENIQTYQSTAEENF----LQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDN 678
            R ++  Q +   + +N     ++E+K  K E +   N+L ++    ++  +     + + 
Sbjct: 1159 RNLKEFQEHLQDSVKNTKDLNVKELK-LKEEITQLTNNLQDMKHLLQLKEEEEETNRQET 1217

Query: 679  QILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLS 738
            + LKEEL   S      +  + R  ED   L+  +   + +   ++ E+  ++ E   L 
Sbjct: 1218 EKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLR 1277

Query: 739  DKI---------CNQHNDPSKTTYISRREKFH 761
             KI         C+Q  D  + T    +E+ +
Sbjct: 1278 IKINELEKKKNQCSQELDMKQRTIQQLKEQLN 1309



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 136/683 (19%), Positives = 275/683 (40%), Gaps = 81/683 (11%)

Query: 101  TLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNY 160
            TL+S +EKL G   +S  Q V++ S  +S+  L ++ +T +   N +    E+ D+++  
Sbjct: 484  TLNSSQEKLFGPVKSS--QDVSLDSNSNSK-ILNVKRATISWE-NSLEDLMEDEDLVEEL 539

Query: 161  NNFYRFLPTAPPNVMSQADTVILDKS-KITVPFLKHGFCENLDDICHSIKQ-MKEELQKS 218
             N          NV ++     LDK+ +    F+ H     L D+   +K+ +  E ++ 
Sbjct: 540  EN-----AEETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLKKKLINEKKEK 594

Query: 219  HDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLN----------- 267
               E  +  E+    T     R   +  + + + +   I EEN +  L            
Sbjct: 595  LTLEFKIREEVTQEFTQYWAQREADFKETLLQERE---ILEENAERRLAIFKDLVGKCDT 651

Query: 268  -----EDIKSKRISELEALVKKLLPFRET---VSKFHVHFCRKCKKLSKSEMHRG---KK 316
                 +DI + ++   EA     L F +    ++K      +  ++L K E       ++
Sbjct: 652  REEAAKDICATKVETEEATACLELKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQE 711

Query: 317  NEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMK------DKERQPFLVKQGSI 370
             E +NK+I    + I +L         T++     K  M+      DK     L+    +
Sbjct: 712  LETSNKKIITQNQRIKELINIIDQKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKL 771

Query: 371  ISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQ 430
            I         +S ++ C  + +  +N L++     KK     S  +    K    +    
Sbjct: 772  ICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNI 831

Query: 431  SLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEE 490
            + I+ +   ++  + L     TI+++L   +E   E  K+           Q +    E+
Sbjct: 832  AEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVH-------FQQELSLSEK 884

Query: 491  KNIQLSLEKQQMME----ALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQD 546
            KN+ LS E QQ+      A+ +L  ++ K Q     +   +N +     ++  N+  I  
Sbjct: 885  KNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQI-- 942

Query: 547  EKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLK------EKERLAKTEQETL---LQII 597
                  K  H  + E  +L +  + S ++++ L+      E++ L  T+ + L     + 
Sbjct: 943  ------KLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVS 996

Query: 598  ETVKDEKL---NLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYK 654
            + VK+ ++   N E +   S  A     +EI    + +S   E   Q+I+  ++E   YK
Sbjct: 997  KQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYK 1056

Query: 655  NSLSEI-GKECEMLSKMVMETKTDNQILKEELKKHS-------QENIKFENSISRLTEDK 706
            +  + +  KE +    ++ E +T  Q LKEEL++ +       Q  ++ + ++S LT+  
Sbjct: 1057 DENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGV 1116

Query: 707  ILLENYVRSIENERDTLEFEMRH 729
               +  ++ +E   +T + E  H
Sbjct: 1117 TCYKAKIKELETILETQKVECSH 1139



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 85/410 (20%), Positives = 179/410 (43%), Gaps = 59/410 (14%)

Query: 380 VNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETY 439
           +NS  E+    ++  Q+   +S     K++ ++   ++ ++ ++ L+   + L++++E  
Sbjct: 485 LNSSQEKLFGPVKSSQDVSLDS-NSNSKILNVKRATISWENSLEDLM-EDEDLVEELENA 542

Query: 440 EKQLKNLVEEKSTIQSKLSKTEEYSKECL--KEFKKIISKYNVLQGQNKTLEEKNIQLSL 497
           E + +N+  E   +   L KT E +K  +  +E +K++     L+   K + EK  +L+L
Sbjct: 543 E-ETQNV--ETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLK--KKLINEKKEKLTL 597

Query: 498 EKQQMMEALDQLKS---------KEHKTQSDMAIVNNENNRMSI------EMEAMKTNIL 542
           E +   E   +            KE   Q    +  N   R++I      + +  +    
Sbjct: 598 EFKIREEVTQEFTQYWAQREADFKETLLQEREILEENAERRLAIFKDLVGKCDTREEAAK 657

Query: 543 LIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKD 602
            I   K   E+ T  L  + + +  EL +++ E+I+ KE+ +  + E ++L+Q +ET   
Sbjct: 658 DICATKVETEEATACLELKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNK 717

Query: 603 EKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYK----NSLS 658
           + +     ++E        E  I   Q  +S  E  F    K   S   I      N   
Sbjct: 718 KIITQNQRIKELINIIDQKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETV 777

Query: 659 EIGKECEMLSKMVMETK--TDNQILKEE-------------LKKHSQENIKFENSISRLT 703
           E+ K+ +  SK+  E K   +N++ ++E             + +  +++ +   +I+ + 
Sbjct: 778 EVPKDSK--SKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIE 835

Query: 704 EDKILLEN------YVRSIEN-------ERDTLEFEMRHLQREYLSLSDK 740
           + ++L EN      ++ +IEN       E+  L  ++ H Q+E LSLS+K
Sbjct: 836 DIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQE-LSLSEK 884



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 122/695 (17%), Positives = 273/695 (39%), Gaps = 125/695 (17%)

Query: 50   IQPQSALKVLQQQLESFQALRMQTLQN---VSMPTENQEENLSMEKSHHFEDSKTLHSV- 105
            ++ +S +  L++ L+ FQ     +++N   +++     +E ++ + +++ +D K L  + 
Sbjct: 1148 LEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEIT-QLTNNLQDMKHLLQLK 1206

Query: 106  --EEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNF 163
              EE+ +      L + ++  S             T NL +++     + +D+ +   + 
Sbjct: 1207 EEEEETNRQETEKLKEELSASS-----------ARTQNLKADLQRKEEDYADLKEKLTDA 1255

Query: 164  YRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFC-ENLDDICHSIKQMKEELQKSHDGE 222
             + +      V    D   L + KI     K   C + LD    +I+Q+KE+L      E
Sbjct: 1256 KKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEE 1315

Query: 223  VALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALV 282
                 E    +   D++   K     I +D    ++E+       + +   ++ E+E L 
Sbjct: 1316 AIQQYE----RACKDLNVKEK-----IIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLA 1366

Query: 283  KKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPR 342
             +L  ++E           KC  L      R  K  +NN ++   GK +T+L+       
Sbjct: 1367 TELEKWKE-----------KCNDLETKNNQRSNKEHENNTDV--LGK-LTNLQDEL---- 1408

Query: 343  YTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESV 402
                   Q   +  + +R+ +L ++  +I++ ++   + +         + ++ Y ++  
Sbjct: 1409 -------QESEQKYNADRKKWLEEKMMLITQAKEAENIRN---------KEMKKYAEDRE 1452

Query: 403  QIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEE 462
            +  K+  E+E     L  K   L    +   Q V   E QLK L      I S + K  E
Sbjct: 1453 RFFKQQNEMEILTAQLTEKDSDLQKWREERDQLVAALEIQLKAL------ISSNVQKDNE 1506

Query: 463  YSKECLKEFKKIISKYNVLQGQNKTLEEKNI------QLSLEKQQMMEALDQLKSKEHKT 516
                 +++ K+IIS+ + ++ Q   ++ K I      +L  E       + + K ++   
Sbjct: 1507 -----IEQLKRIISETSKIETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKIEDGSV 1561

Query: 517  QSDMAIVNNENNR--------MSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNE 568
              D   V+ EN++        + I+   ++ N + ++         T ++ K +    NE
Sbjct: 1562 VLDSCEVSTENDQSTRFPKPELEIQFTPLQPNKMAVK-HPGCTTPVTVKIPKARKRKSNE 1620

Query: 569  LKESQLEIIQLK--------------EKERLAKTEQETLLQ--------IIETVKDEKLN 606
            ++E  ++    K              ++    K EQ+  ++        +        +N
Sbjct: 1621 MEEDLVKCENKKNATPRTNLKFPISDDRNSSVKKEQKVAIRPSSKKTYSLRSQASIIGVN 1680

Query: 607  LETTLQESTAAR---------QIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSL 657
            L T  +E T  +          I++ + + I    S+++ + ++  K   S+    K  L
Sbjct: 1681 LATKKKEGTLQKFGDFLQHSPSILQSKAKKIIETMSSSKLSNVEASKENVSQPKRAKRKL 1740

Query: 658  --SEIGKECEMLSKMVM----ETKTDNQILKEELK 686
              SEI    ++  ++++      ++D+QI+K  L+
Sbjct: 1741 YTSEISSPIDISGQVILMDQKMKESDHQIIKRRLR 1775


>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
          Length = 2325

 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 132/597 (22%), Positives = 256/597 (42%), Gaps = 104/597 (17%)

Query: 207  SIKQMKEELQKSHDGEVALTNELQTLQTD-PDVHRNGKYDMSPIHQDKMNFIKEENLDGN 265
            S +Q ++E+++ H     L  E ++L+ +  ++HR  +       Q + +FI + N++  
Sbjct: 1348 SKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQK-----RQQQKDFI-DGNVESL 1401

Query: 266  LNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKL---SKSEMHRGKKNEKN-- 320
            + E    K +   E +V ++    +T+ K      R+  +L   ++SE+   K+  KN  
Sbjct: 1402 MTELEIEKSLKHHEDIVDEIECIEKTLLKRRSEL-READRLLAEAESELSCTKEKTKNAV 1460

Query: 321  ------NKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKD--KERQPFLVKQGSIIS 372
                   + +  T  +  +L+  ++     L   DQ    ++   K+ +   +KQ  I+ 
Sbjct: 1461 EKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILK 1520

Query: 373  ENEKTSKVNSVTEQCVAK--------IQYLQN--------------YLKES-VQIQKKVM 409
            E  K         QC++K        +Q LQ                LKES V +Q K  
Sbjct: 1521 EINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRA 1580

Query: 410  ELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTE-EYSKEC- 467
            ELE     + S+ + +    + L  K E       ++V+ K+ +Q  L   E E +++C 
Sbjct: 1581 ELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCN 1640

Query: 468  -LKEFKKIISKYNVLQGQ-NKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNN 525
             ++E K ++ + +  +G+ N  + E+  QL+L KQ++            K + ++ +V  
Sbjct: 1641 HIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEI-----------EKEEENLQVVLR 1689

Query: 526  ENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERL 585
            + ++   E++    NIL      +ML+ + H+L   K  L ++ + S+LE  Q+   E  
Sbjct: 1690 QMSKHKTELK----NIL------DMLQLENHELQGLK--LQHDQRVSELEKTQVAVLEE- 1736

Query: 586  AKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKN 645
             K E E L QI +  K E              +Q++ER+   I+  + TAE   LQ    
Sbjct: 1737 -KLELENLQQISQQQKGE----------IEWQKQLLERDKREIE--RMTAESRALQSCVE 1783

Query: 646  AKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQIL--KEELKKHSQENI--------KF 695
              S+         ++ ++C++  K + +TK   ++L   EE  K  Q N+        K 
Sbjct: 1784 CLSKEK------EDLQEKCDIWEKKLAQTK---RVLAAAEENSKMEQSNLEKLELNVRKL 1834

Query: 696  ENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTT 752
            +  + +L  DK+ L N + +++ +       +  LQ E  ++ D +     D   TT
Sbjct: 1835 QQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTT 1891



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 94/498 (18%), Positives = 220/498 (44%), Gaps = 76/498 (15%)

Query: 271  KSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKN 330
            K   I E+++L+++L  F++   + +V    +  +L+  +    K+ E     +    K+
Sbjct: 1638 KCNHIREVKSLLEEL-SFQK--GELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKH 1694

Query: 331  ITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAK 390
             T+LK          + LD    ++++ E Q   ++    +SE EKT       +  +  
Sbjct: 1695 KTELK----------NILDML--QLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELEN 1742

Query: 391  IQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEK 450
            +Q +    K  ++ QK+++E +      K +++ +   +++L   VE   K+ ++L E+ 
Sbjct: 1743 LQQISQQQKGEIEWQKQLLERD------KREIERMTAESRALQSCVECLSKEKEDLQEKC 1796

Query: 451  STIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQ-LSLEKQQMMEALDQL 509
               + KL++T           K++++       +N  +E+ N++ L L  +++ + LDQL
Sbjct: 1797 DIWEKKLAQT-----------KRVLAAAE----ENSKMEQSNLEKLELNVRKLQQELDQL 1841

Query: 510  KSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQD-----EKEMLEKKTHQ--LLKEK 562
               +    +D++ +  +       + +++  +  +QD     ++++L    HQ  LL E+
Sbjct: 1842 NRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQ 1901

Query: 563  SSL----------------GNELKESQLEIIQLK-EKERLAKTEQETLLQIIETVKDEKL 605
            + L                  E K+ QL+++Q + E+ +L   +QE + Q ++  ++ + 
Sbjct: 1902 TRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESE- 1960

Query: 606  NLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECE 665
              E+ L+ S    +  + ++E   T Q +  +  L ++  A+        +L E  + CE
Sbjct: 1961 --ESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERV----RTLQEEERWCE 2014

Query: 666  MLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYV--------RSIE 717
             L K + +TK      +++L + S E +  +     +  D  LL N          + + 
Sbjct: 2015 SLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVA 2074

Query: 718  NERDTLEFEMRHLQREYL 735
            + ++ L+ +   L++  L
Sbjct: 2075 SLKEALKIQRSQLEKNLL 2092



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 96/471 (20%), Positives = 186/471 (39%), Gaps = 83/471 (17%)

Query: 326 ITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDK--ERQPFLVKQGSIISENEKTSKVNSV 383
           + G+ +T         R++L  +++ + +++ K  E +    KQ   + E +   K+N  
Sbjct: 250 LEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKS 309

Query: 384 TEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQL 443
                         LKE   +QK+  E    +LN K+++       Q  I+     +KQ 
Sbjct: 310 --------------LKEEAMLQKQSCEELKSDLNTKNEL-----LKQKTIELTRACQKQY 350

Query: 444 KNLVEEKS--TIQSKLSKTEEYSKECLKEFK---------KIISKYNVLQGQNKTLEEKN 492
           + L +E +   I +K      Y  E  +  K         K   K N+   ++  ++   
Sbjct: 351 E-LEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQ 409

Query: 493 IQLSLEKQQMMEAL--DQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEM 550
             + ++K +  E L  D +  + H T  D  + + E      ++ A +T +  + DE   
Sbjct: 410 A-VQIKKMEPDEQLRNDHMNLRGH-TPLDTQLEDKEK-----KISAAQTRLSELHDE--- 459

Query: 551 LEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETT 610
           +EK   Q+L+         +  QL+ I    K+ L K +    LQ++  ++ E L+LE  
Sbjct: 460 IEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYK-QLSGRLQLVNKLRQEALDLELQ 518

Query: 611 LQESTAARQIMEREIENIQTY-----QSTAEENFLQEIKNAKSEASIYKNS--------- 656
           +++        ++EI+++Q           + + ++  K+ K +     N          
Sbjct: 519 MEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRL 578

Query: 657 ---LSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENI----------------KFEN 697
              LS I KE E + K + E  T+ QI   E  K   E +                + +N
Sbjct: 579 DEILSRIAKETEEI-KDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQN 637

Query: 698 SISRLTEDKILLENYVRSIENERDTLE---FEMRHLQREYLSLSDKICNQH 745
              +L ++K  L   +  +E ERD LE    +  ++++E   L   +  QH
Sbjct: 638 ECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQH 688



 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 142/739 (19%), Positives = 295/739 (39%), Gaps = 151/739 (20%)

Query: 46   SENQIQPQSALKVLQQQLESFQALRMQTLQNVSMPTENQ----EENLSMEKSHHFEDSKT 101
            S+++ + ++ L +LQ +    Q L++Q  Q VS   + Q    EE L +E          
Sbjct: 1692 SKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELEN--------- 1742

Query: 102  LHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDN---LSSNIIIHPSENSDILK 158
            L  + ++  G+        +    Q+   D   +   T     L S +     E  D+ +
Sbjct: 1743 LQQISQQQKGE--------IEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQE 1794

Query: 159  NYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKS 218
              + + + L      + +  +   +++S             NL+ +  +++++++EL + 
Sbjct: 1795 KCDIWEKKLAQTKRVLAAAEENSKMEQS-------------NLEKLELNVRKLQQELDQL 1841

Query: 219  HDGEVALTNELQTLQTDPDVHR---NGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRI 275
            +  +++L N++  +Q      R   N   +     QD +N  K++ L    ++D+    +
Sbjct: 1842 NRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDV---LL 1898

Query: 276  SELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLK 335
            SE   L K +    E  ++F       C+          K+ E   +++ +    I + K
Sbjct: 1899 SEQTRLQKDI---SEWANRF-----EDCQ----------KEEETKQQQLQVLQNEIEENK 1940

Query: 336  FHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEK--TSKVNSVTEQCVAKIQY 393
               ++ +  + F      +   KER+          SE  K  TSKV             
Sbjct: 1941 L--KLVQQEMMF------QRLQKERE----------SEESKLETSKVT------------ 1970

Query: 394  LQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTI 453
                      ++++  +LE E  + KSK+         ++ KV   E++++ L EE+   
Sbjct: 1971 ----------LKEQQHQLEKELTDQKSKL-------DQVLSKVLAAEERVRTLQEEERWC 2013

Query: 454  QSKLSKTEEYSKECLKE-FKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMM----EALDQ 508
            +S L KT   +K  L E  ++++ K   L    K  +      SL + Q +    +A  Q
Sbjct: 2014 ES-LEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQ 2072

Query: 509  LKS-----KEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKS 563
            + S     K  ++Q +  ++  +     I+ E M T  L+ QD  E    +  +L+KE +
Sbjct: 2073 VASLKEALKIQRSQLEKNLLEQKQENSCIQKE-MATIELVAQDNHE----RARRLMKELN 2127

Query: 564  SLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDE----KLNLETTLQESTAARQ 619
             +  E  E + ++   K+ ER      + +  +   VKDE      NL   L E  A  +
Sbjct: 2128 QMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLE 2187

Query: 620  IMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQ 679
             +    EN++    + +EN    +     E    K + S++          +M+     +
Sbjct: 2188 AILERNENLEGELESLKENLPFTMNEGPFEE---KLNFSQV---------HIMDEHWRGE 2235

Query: 680  ILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSD 739
             L+E+L +H ++ +K +       + ++L       I+ +R T E  +  L+R+  +L +
Sbjct: 2236 ALREKL-RHREDRLKAQLRHCMSKQAEVL-------IKGKRQT-EGTLHSLRRQVDALGE 2286

Query: 740  KICNQHNDPSKTTYISRRE 758
             + +   D + +  +S+ E
Sbjct: 2287 LVTSTSADSASSPSLSQLE 2305



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 128/724 (17%), Positives = 284/724 (39%), Gaps = 90/724 (12%)

Query: 60  QQQLESFQALRMQTLQNVSMPTEN---QEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNS 116
           Q + E+F+   ++ ++ +    E    + E L  +++   E+ K    + + L  +++  
Sbjct: 258 QDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQ 317

Query: 117 LPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMS 176
                 + S +++++ L L+  T  L+        +    L+    FY+      P    
Sbjct: 318 KQSCEELKSDLNTKNEL-LKQKTIELT-----RACQKQYELEQELAFYKIDAKFEPLNYY 371

Query: 177 QADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDP 236
            ++   +DK+    P++                + K  +  +    +     +Q  + +P
Sbjct: 372 PSEYAEIDKAPDESPYIGKS-------------RYKRNMFATESYIIDSAQAVQIKKMEP 418

Query: 237 DVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFH 296
           D           +  D MN      LD  L +  K K+IS  +  + +L    + + K  
Sbjct: 419 D---------EQLRNDHMNLRGHTPLDTQLED--KEKKISAAQTRLSEL---HDEIEKAE 464

Query: 297 VHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMK 356
               R  ++  + E           K+I   GK++   +   R     L  +++ + E  
Sbjct: 465 QQILRATEEFKQLE------EAIQLKKISEAGKDLLYKQLSGR-----LQLVNKLRQEAL 513

Query: 357 DKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENL 416
           D E Q  + KQ   I+  +K  K   +    +       +++K     QK   E + + +
Sbjct: 514 DLELQ--MEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKA----QKSGKEQQLDIM 567

Query: 417 NLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIIS 476
           N   + + L      ++ ++    +++K+L E+ +  + +++  E   K+       +  
Sbjct: 568 N--KQYQQLESRLDEILSRIAKETEEIKDLEEQLT--EGQIAANEALKKDLEGVISGLQE 623

Query: 477 KYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSI---- 532
               ++GQ    + +  +L  EK+ +++ L +++  + + Q ++  ++ EN R  +    
Sbjct: 624 YLGTIKGQATQAQNECRKLRDEKETLLQRLTEVE--QERDQLEIVAMDAENMRKELAELE 681

Query: 533 ----EMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKT 588
               E   +  ++   Q +    E +    L  + +  N+LKE      +L++  RL + 
Sbjct: 682 SALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKE------ELEKVTRLTQL 735

Query: 589 EQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNA-K 647
           EQ  L   +E    E+  L+  L ++  +    E+E EN + +   A+   LQ+  N  K
Sbjct: 736 EQSALQAELEK---ERQALKNALGKAQFSE---EKEQENSELH---AKLKHLQDDNNLLK 786

Query: 648 SEASIYKNSLSEIGKEC---EMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTE 704
            +   ++N L+ +       E ++  V E +   ++   E+  HS  ++    S++ L  
Sbjct: 787 QQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDV-LGKSLADL-- 843

Query: 705 DKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRREKFHFDN 764
            K   E   RS + ERD  +   R LQ E     +K+     +  +    +   + +FD 
Sbjct: 844 QKQFSEILARS-KWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDK 902

Query: 765 YTHE 768
             HE
Sbjct: 903 RQHE 906



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 101/554 (18%), Positives = 236/554 (42%), Gaps = 81/554 (14%)

Query: 252  DKMNFIKEENLDGNL--NEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKS 309
            +++  ++E+  +G +  NE +K     +LE ++  L  +  T+         +C+KL   
Sbjct: 590  EEIKDLEEQLTEGQIAANEALKK----DLEGVISGLQEYLGTIKGQATQAQNECRKLRDE 645

Query: 310  E---MHRGKKNEKNNKEIPITG-------KNITDLKFHSRVPRYTLSFLDQTKHEMKDKE 359
            +   + R  + E+   ++ I         K + +L+   +      + L QT+ ++   E
Sbjct: 646  KETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYE 705

Query: 360  RQPFL------VKQGSIISENEKTSKVNSVTEQCV-AKIQYLQNYLKESVQIQKKVMELE 412
             +          +   +  E EK +++  + +  + A+++  +  LK ++   +   E E
Sbjct: 706  AELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKE 765

Query: 413  SENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFK 472
             EN  L +K+K L      L Q+++ ++  L ++V+     +   ++ +E  ++ LK   
Sbjct: 766  QENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRK-LKLGT 824

Query: 473  KIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNE------ 526
              ++ ++      K+L +   Q S    +     D+ + +E K Q +MA+   +      
Sbjct: 825  GEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQE 884

Query: 527  ----------NNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLE- 575
                        RM+ +    +  I  +++E   L++    + + +     +L+E+  E 
Sbjct: 885  EFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEK 944

Query: 576  ---IIQLKEKERLAKTE----QETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENI 628
               + QL+E E+  K E    QE +  + + +K  K  + T+ + +TA   I + +++++
Sbjct: 945  ERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSL 1004

Query: 629  -----QTYQSTAEE------------NFLQEIKNAKSEASIYKNSLSEIGKECEM-LSKM 670
                 +  Q  AEE               +++  A++E  + +N L + G++  + + K 
Sbjct: 1005 HGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKT 1064

Query: 671  VMETKTDNQILKEELKKHSQENIKFENSISRL--------TEDKILLENYVRSIENERDT 722
             + T  ++Q+L+ E    + E  + E  I+RL        +++K   EN +  I   R  
Sbjct: 1065 GVGTGANSQVLEIEKLNETMERQRTE--IARLQNVLDLTGSDNKGGFENVLEEIAELRRE 1122

Query: 723  LEFEMRHLQREYLS 736
            + +     Q +Y+S
Sbjct: 1123 VSY-----QNDYIS 1131



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 65/334 (19%), Positives = 141/334 (42%), Gaps = 16/334 (4%)

Query: 447  VEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQN-KTLEE--KNIQLSLEKQQMM 503
            V E   +++++S+ E+  +  LK  K+        + Q+ K +EE   NI   L++++ +
Sbjct: 1315 VPEHHNLENEVSRLEDIMQH-LKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSL 1373

Query: 504  EA-LDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKT--NILLIQDEKEMLEKKTHQLLK 560
            E  +++L     K Q     ++     +  E+E  K+  +   I DE E +EK    LLK
Sbjct: 1374 ECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEK---TLLK 1430

Query: 561  EKSSLGNE---LKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAA 617
             +S L      L E++ E+   KEK + A  +     + +   + +   LE   QE+   
Sbjct: 1431 RRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVN 1490

Query: 618  RQIMEREIENIQTYQSTAEENFLQE---IKNAKSEASIYKNSLSEIGKECEMLSKMVMET 674
                ++++ ++Q      E++ +++   +K      +   +    + K+ E L++ + + 
Sbjct: 1491 LVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKL 1550

Query: 675  KTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREY 734
            + D ++ +     H Q   + E  +     +   L++ V S + E   L+ ++ H + E 
Sbjct: 1551 QKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEEL 1610

Query: 735  LSLSDKICNQHNDPSKTTYISRREKFHFDNYTHE 768
              L   +     D  +   +   E     N+  E
Sbjct: 1611 HLLQGSMVQAKADLQEALRLGETEVTEKCNHIRE 1644



 Score = 33.5 bits (75), Expect = 0.80
 Identities = 38/180 (21%), Positives = 84/180 (46%), Gaps = 15/180 (8%)

Query: 556  HQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQEST 615
            H  + E  +L NE+   +  +  LK K+R  +  + +  Q  + +++   N++  LQE  
Sbjct: 1312 HCNVPEHHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKK 1371

Query: 616  AARQIMEREIENIQTYQSTAEENFLQ-EIKNAKSEASIYKN--SLSEIGKECEMLSKMVM 672
            +    +E     +Q  Q   +++F+   +++  +E  I K+     +I  E E + K ++
Sbjct: 1372 SLECEVEELHRTVQKRQQ--QKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLL 1429

Query: 673  ETKTD----NQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMR 728
            + +++    +++L E   + S    K +N++ + T+ K  L      ++ E D  E E R
Sbjct: 1430 KRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSL------LQTESDAEELERR 1483


>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
           [Homo sapiens]
          Length = 1354

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 126/621 (20%), Positives = 272/621 (43%), Gaps = 73/621 (11%)

Query: 160 YNNFYRFLPTAPPN---VMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEEL- 215
           Y +  R+L +A PN     S AD  + +  + T+          L++  H+  Q+K+E+ 
Sbjct: 399 YYSNRRYLSSANPNDNRTSSNADKSLQESLQKTI--------YKLEEQLHNEMQLKDEME 450

Query: 216 QKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRI 275
           QK     + L   ++ L  + +  RN +  +S I ++KM      N      E    KR 
Sbjct: 451 QKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKR- 509

Query: 276 SELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLK 335
             +E  V  L    E + K   +     +KLS+ +    + N+    E   +   +   K
Sbjct: 510 RNVENEVSTLKDQLEDLKKVSQNSQLANEKLSQLQKQLEEANDLLRTE---SDTAVRLRK 566

Query: 336 FHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQ-YL 394
            H+ + + ++S L+    E++++ R          I EN K     S T++   ++Q  L
Sbjct: 567 SHTEMSK-SISQLESLNRELQERNR----------ILENSK-----SQTDKDYYQLQAIL 610

Query: 395 QNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQ 454
           +   ++     + + +L++   +L+ ++K L    +  ++KVE   K+ ++++      +
Sbjct: 611 EAERRDRGHDSEMIGDLQARITSLQEEVKHL----KHNLEKVEGERKEAQDMLNHSEKEK 666

Query: 455 SKLSKTEEYSKECLKE-FKKIISKYNV----LQGQNKTLEEKNIQLSLEKQQMMEALDQL 509
           + L     Y  + L++  ++ ++++ V    L  +++++EE     S+   +M + L + 
Sbjct: 667 NNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAK---SVAMCEMEKKLKEE 723

Query: 510 KSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQL---LKEKSS-- 564
           +    K ++ +  +  + + + ++++  +  +  +   KE +E +   L   L+++S+  
Sbjct: 724 REAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNKR 783

Query: 565 --LGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIME 622
             L NELK    E   LK  E+  K E  TLL+    ++ E   L    + +    + ++
Sbjct: 784 LLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQ 843

Query: 623 REIENIQTY---------------QSTAEENF--LQEIKNAKSEASIYKNSLSEIGKECE 665
            ++E  Q +               +    EN   +QE++N K E    +  L+E   E E
Sbjct: 844 DQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEK-ETLATQLDLAETKAESE 902

Query: 666 MLSKMVMETK--TDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTL 723
            L++ ++E +     Q  K+   ++ QE    ++++SRL E   +L   +  +  E + L
Sbjct: 903 QLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENEEL 962

Query: 724 EFEMRHLQREY-LSLSDKICN 743
             +M+  + EY L   ++I N
Sbjct: 963 TEKMKKAEEEYKLEKEEEISN 983



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 70/352 (19%), Positives = 143/352 (40%), Gaps = 50/352 (14%)

Query: 199  ENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIK 258
            E ++D    +K +  +L++  +  + L NEL+T   + D  +  +  M    + ++N + 
Sbjct: 763  ERMED---EVKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQM----KQEINTLL 815

Query: 259  EEN--LDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKK 316
            E    L+  L +  K  R +E +  +++L    E    F   +  + K+L +    + ++
Sbjct: 816  EAKRLLEFELAQLTKQYRGNEGQ--MRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRE 873

Query: 317  NEK------NNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSI 370
            N K      N KE   T  ++ + K  S   +     L++   E+  + ++     +  I
Sbjct: 874  NLKKIQELQNEKETLATQLDLAETKAESE--QLARGLLEEQYFELTQESKKAASRNRQEI 931

Query: 371  ISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKV-----MELESENLNLKSKMKPL 425
              ++   S++          I+ L+   +E  +  KK      +E E E  NLK+  +  
Sbjct: 932  TDKDHTVSRLEEANSMLTKDIEILRRENEELTEKMKKAEEEYKLEKEEEISNLKAAFE-- 989

Query: 426  IFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQN 485
                              KN+  E++     ++K  E      K+FK    K N    + 
Sbjct: 990  ------------------KNINTERTLKTQAVNKLAEIMNR--KDFKIDRKKANTQDLRK 1029

Query: 486  KTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDM--AIVNNENNRMSIEME 535
            K  E + +QL L +++  E  +Q+  K  K  +DM   +V    +R  ++M+
Sbjct: 1030 KEKENRKLQLELNQER--EKFNQMVVKHQKELNDMQAQLVEECAHRNELQMQ 1079


>gi|109134347 NY-REN-58 antigen [Homo sapiens]
          Length = 701

 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 119/570 (20%), Positives = 241/570 (42%), Gaps = 77/570 (13%)

Query: 198 CENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFI 257
           CE+      ++K     LQ  H   V L NEL+ L           ++     Q+K+  +
Sbjct: 42  CEHHKANYQTLKAEHTRLQNEH---VKLQNELKHL-----------FNEKQTQQEKLQLL 87

Query: 258 KEENLDGNLNEDIKSKRISELEALVKKLL-------------PFRETVSKF--HVHFCRK 302
            EE L G L E  K     +L+ L  + L             P RE        V   R 
Sbjct: 88  LEE-LRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRA 146

Query: 303 CKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQP 362
                + E    K   ++ KE      +   +K+ S + R     L++ K E++++    
Sbjct: 147 VYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIAR-----LEEDKEELRNQLLNV 201

Query: 363 FLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKM 422
            L K          + +V  +  + V   Q L+    E  +++ +    E++  N +   
Sbjct: 202 DLTKD---------SKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQ 252

Query: 423 KPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQ 482
              +   Q+ ++ +E  EKQ  NL  E+  ++ +L  + E +   + +  K   + N L 
Sbjct: 253 VRQLAEMQATVRSLEA-EKQSANLRAER--LEKELQSSSEQNTFLINKLHKAEREINTLS 309

Query: 483 GQNKTLEEKN-IQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNI 541
            + K L+  N ++++  K +   A  +L+ + +K QS++  + ++N  +   +E  K  +
Sbjct: 310 SKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHK--V 367

Query: 542 LLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVK 601
           LL++ ++E++ K   Q  KE         E   +++ L+++    K E E  L  +E +K
Sbjct: 368 LLVEKDRELIRKV--QAAKE---------EGYQKLVVLQDE----KLELENRLADLEKMK 412

Query: 602 --------DEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIY 653
                    EK   E  L+ S  A +I  +E+++++  +   +   ++  +  K+E S  
Sbjct: 413 VEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRL-KLQQQIVTIENAEKEKNENSDL 471

Query: 654 KNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQE--NIKFENSISRLTEDKILLEN 711
           K  +S +  +   L++   +    NQ+LKE +++  QE  N + +   ++L  +K L E 
Sbjct: 472 KQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEK 531

Query: 712 YVRSIENERDTLEFEMRHLQREYLSLSDKI 741
            ++ +E E+  L   +   + +Y    +K+
Sbjct: 532 QIQWLE-EKHKLHERITDREEKYNQAKEKL 560



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 99/467 (21%), Positives = 192/467 (41%), Gaps = 59/467 (12%)

Query: 257 IKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKK 316
           IK E+    L ED +  R   L   + K     E +++  V+ C+K K L         K
Sbjct: 178 IKYESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAEL--K 235

Query: 317 NEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKH------EMKDKERQPFLVKQGSI 370
            EK N E  +       ++  + + + T+  L+  K       E  +KE Q    +   +
Sbjct: 236 AEKENSEAQVENAQRIQVRQLAEM-QATVRSLEAEKQSANLRAERLEKELQSSSEQNTFL 294

Query: 371 ISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQ--KKVMELESENLNLKSKMKPLIFT 428
           I++  K  +  +     V ++++        ++++  +   ELE E   ++S++  L   
Sbjct: 295 INKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSD 354

Query: 429 TQSLIQKVETYEKQLKNLVEEKSTIQSKL--SKTEEYSKECLKEFKKIISKYNVLQGQNK 486
            + L   VE + K L  LVE+   +  K+  +K E Y K  + + +K+  + N L    K
Sbjct: 355 NEILKAAVE-HHKVL--LVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELE-NRLADLEK 410

Query: 487 TLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQD 546
              E ++    EK Q  E L   +  E  T+ ++          S+ ++  +  + +   
Sbjct: 411 MKVEHDVWRQSEKDQYEEKLRASQMAEEITRKEL---------QSVRLKLQQQIVTIENA 461

Query: 547 EKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDE--- 603
           EKE           E S L  ++   Q+++  L + E       + L +++E +K E   
Sbjct: 462 EKEK---------NENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRN 512

Query: 604 --------KLNLETTLQESTAA-----RQIMEREIENIQTYQSTAEENFLQEIKNAKSEA 650
                   +L  E TL+E          ++ ER  +  + Y   A+E   +     K   
Sbjct: 513 FRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQ-AKEKLQRAAIAQKKRK 571

Query: 651 SIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFEN 697
           S+++N L  + ++ E+L     E +T+NQ+L       +++N+ FE+
Sbjct: 572 SLHENKLKRLQEKVEVLEAKKEELETENQVL-------NRQNVPFED 611



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 50/198 (25%), Positives = 95/198 (47%), Gaps = 16/198 (8%)

Query: 543 LIQDEKEMLE--KKTHQLLK-EKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIET 599
           ++ DE+   E  K  +Q LK E + L NE  + Q E+  L  +++   T+QE L  ++E 
Sbjct: 34  MLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQ---TQQEKLQLLLEE 90

Query: 600 VKDEKLNLETTLQESTAARQIMEREIENIQTY-QSTAEENFLQEIKNAKSEASIYKNSLS 658
           ++ E +     L+E    + +  +++E ++   Q   E    +  +N   E   Y+   +
Sbjct: 91  LRGELVEKTKDLEEMKL-QILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYN 149

Query: 659 EIGKECEMLSKMVMETKTDNQILKEELKKHSQEN-IKFENSISRLTEDKILLENYVRSIE 717
           ++  E   L       K++ +  KEE  +   E  IK+E+ I+RL EDK  L N + +++
Sbjct: 150 KLRYEHTFL-------KSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVD 202

Query: 718 NERDTLEFEMRHLQREYL 735
             +D+   E    ++ YL
Sbjct: 203 LTKDSKRVEQLAREKVYL 220


>gi|109134355 NY-REN-58 antigen [Homo sapiens]
          Length = 701

 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 119/570 (20%), Positives = 241/570 (42%), Gaps = 77/570 (13%)

Query: 198 CENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFI 257
           CE+      ++K     LQ  H   V L NEL+ L           ++     Q+K+  +
Sbjct: 42  CEHHKANYQTLKAEHTRLQNEH---VKLQNELKHL-----------FNEKQTQQEKLQLL 87

Query: 258 KEENLDGNLNEDIKSKRISELEALVKKLL-------------PFRETVSKF--HVHFCRK 302
            EE L G L E  K     +L+ L  + L             P RE        V   R 
Sbjct: 88  LEE-LRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRA 146

Query: 303 CKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQP 362
                + E    K   ++ KE      +   +K+ S + R     L++ K E++++    
Sbjct: 147 VYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIAR-----LEEDKEELRNQLLNV 201

Query: 363 FLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKM 422
            L K          + +V  +  + V   Q L+    E  +++ +    E++  N +   
Sbjct: 202 DLTKD---------SKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQ 252

Query: 423 KPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQ 482
              +   Q+ ++ +E  EKQ  NL  E+  ++ +L  + E +   + +  K   + N L 
Sbjct: 253 VRQLAEMQATVRSLEA-EKQSANLRAER--LEKELQSSSEQNTFLINKLHKAEREINTLS 309

Query: 483 GQNKTLEEKN-IQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNI 541
            + K L+  N ++++  K +   A  +L+ + +K QS++  + ++N  +   +E  K  +
Sbjct: 310 SKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHK--V 367

Query: 542 LLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVK 601
           LL++ ++E++ K   Q  KE         E   +++ L+++    K E E  L  +E +K
Sbjct: 368 LLVEKDRELIRKV--QAAKE---------EGYQKLVVLQDE----KLELENRLADLEKMK 412

Query: 602 --------DEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIY 653
                    EK   E  L+ S  A +I  +E+++++  +   +   ++  +  K+E S  
Sbjct: 413 VEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRL-KLQQQIVTIENAEKEKNENSDL 471

Query: 654 KNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQE--NIKFENSISRLTEDKILLEN 711
           K  +S +  +   L++   +    NQ+LKE +++  QE  N + +   ++L  +K L E 
Sbjct: 472 KQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEK 531

Query: 712 YVRSIENERDTLEFEMRHLQREYLSLSDKI 741
            ++ +E E+  L   +   + +Y    +K+
Sbjct: 532 QIQWLE-EKHKLHERITDREEKYNQAKEKL 560



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 99/467 (21%), Positives = 192/467 (41%), Gaps = 59/467 (12%)

Query: 257 IKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKK 316
           IK E+    L ED +  R   L   + K     E +++  V+ C+K K L         K
Sbjct: 178 IKYESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAEL--K 235

Query: 317 NEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKH------EMKDKERQPFLVKQGSI 370
            EK N E  +       ++  + + + T+  L+  K       E  +KE Q    +   +
Sbjct: 236 AEKENSEAQVENAQRIQVRQLAEM-QATVRSLEAEKQSANLRAERLEKELQSSSEQNTFL 294

Query: 371 ISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQ--KKVMELESENLNLKSKMKPLIFT 428
           I++  K  +  +     V ++++        ++++  +   ELE E   ++S++  L   
Sbjct: 295 INKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSD 354

Query: 429 TQSLIQKVETYEKQLKNLVEEKSTIQSKL--SKTEEYSKECLKEFKKIISKYNVLQGQNK 486
            + L   VE + K L  LVE+   +  K+  +K E Y K  + + +K+  + N L    K
Sbjct: 355 NEILKAAVE-HHKVL--LVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELE-NRLADLEK 410

Query: 487 TLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQD 546
              E ++    EK Q  E L   +  E  T+ ++          S+ ++  +  + +   
Sbjct: 411 MKVEHDVWRQSEKDQYEEKLRASQMAEEITRKEL---------QSVRLKLQQQIVTIENA 461

Query: 547 EKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDE--- 603
           EKE           E S L  ++   Q+++  L + E       + L +++E +K E   
Sbjct: 462 EKEK---------NENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRN 512

Query: 604 --------KLNLETTLQESTAA-----RQIMEREIENIQTYQSTAEENFLQEIKNAKSEA 650
                   +L  E TL+E          ++ ER  +  + Y   A+E   +     K   
Sbjct: 513 FRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQ-AKEKLQRAAIAQKKRK 571

Query: 651 SIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFEN 697
           S+++N L  + ++ E+L     E +T+NQ+L       +++N+ FE+
Sbjct: 572 SLHENKLKRLQEKVEVLEAKKEELETENQVL-------NRQNVPFED 611



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 50/198 (25%), Positives = 95/198 (47%), Gaps = 16/198 (8%)

Query: 543 LIQDEKEMLE--KKTHQLLK-EKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIET 599
           ++ DE+   E  K  +Q LK E + L NE  + Q E+  L  +++   T+QE L  ++E 
Sbjct: 34  MLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQ---TQQEKLQLLLEE 90

Query: 600 VKDEKLNLETTLQESTAARQIMEREIENIQTY-QSTAEENFLQEIKNAKSEASIYKNSLS 658
           ++ E +     L+E    + +  +++E ++   Q   E    +  +N   E   Y+   +
Sbjct: 91  LRGELVEKTKDLEEMKL-QILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYN 149

Query: 659 EIGKECEMLSKMVMETKTDNQILKEELKKHSQEN-IKFENSISRLTEDKILLENYVRSIE 717
           ++  E   L       K++ +  KEE  +   E  IK+E+ I+RL EDK  L N + +++
Sbjct: 150 KLRYEHTFL-------KSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVD 202

Query: 718 NERDTLEFEMRHLQREYL 735
             +D+   E    ++ YL
Sbjct: 203 LTKDSKRVEQLAREKVYL 220


>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
          Length = 3907

 Score = 77.0 bits (188), Expect = 6e-14
 Identities = 116/557 (20%), Positives = 238/557 (42%), Gaps = 73/557 (13%)

Query: 202  DDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEEN 261
            DD+   +K ++ ++++     + L  E  T   D    R     +    +    F+ E+ 
Sbjct: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDL---RQQNQALEKQLEKMRKFLDEQA 2073

Query: 262  LDGNLNEDIKSKRISELEALVKKLLPFR----------ETVSKFHVHFCRKCKKLSKSEM 311
            +D     D+  + I +LE  +K +  F+          E ++        KC +L  S+ 
Sbjct: 2074 IDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKE 2133

Query: 312  HRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSII 371
               +  ++ N+EI      + +L+    V   T   ++  KH     E +P L  +  + 
Sbjct: 2134 QLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKH-FGAVEAKPELSLEVQLQ 2192

Query: 372  SENE----KTSKVNSVTEQCVAKIQYLQNYLKE------SVQIQKK-----VMELESENL 416
            +E +    K  ++ ++ EQ     + L+N  +E       ++IQKK     + ELE EN 
Sbjct: 2193 AERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENK 2252

Query: 417  NLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEK--STIQSKLSKTEEYSKEC--LKEFK 472
              K  M+ L       I++ +    Q ++++  K    IQ K  + ++ +++   L++  
Sbjct: 2253 LFKDDMEKLGLA----IKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQL 2308

Query: 473  KIISKYNVLQGQNKTLEEKNIQLSL-------EKQQMMEALDQLKSKEHKTQSDMAIVNN 525
            KI +   V++ +N+ + +   Q+          K+   E ++QL     K Q ++A +  
Sbjct: 2309 KITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQ 2368

Query: 526  ENNR----MSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKE 581
            + +     +S E +++K  + ++  EK  LE++     +E + + N LKE+  ++ QL +
Sbjct: 2369 KTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQ 2428

Query: 582  KERLAKTEQETLLQI-----------IETVKDEKLNLETTLQESTAARQIMEREIENIQT 630
            +    K E+E++ +I           I+ +  +K  LE  L E         + +EN QT
Sbjct: 2429 ELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDAL------KSLEN-QT 2481

Query: 631  YQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQ 690
            Y  + EEN    I N ++     ++++S    E     K + + +   Q   E L+K   
Sbjct: 2482 YFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQK--- 2538

Query: 691  ENIKFENSISRLTEDKI 707
               K  N + ++ E+K+
Sbjct: 2539 ---KIVN-LQKIVEEKV 2551



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 157/773 (20%), Positives = 317/773 (41%), Gaps = 108/773 (13%)

Query: 19   SASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQQLESFQALRMQTLQNVS 78
            S  K   SSE +K+   +  E       ++Q +     ++ Q+     + LR +  +   
Sbjct: 383  SKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYG 442

Query: 79   MPTENQEENLSMEKSHHFEDSKTLHSVEEK----------LSGDSVNSLPQSVNVPSQIH 128
                  ++ L  +     E+ KT H  E +          ++ D +  +  ++N    I 
Sbjct: 443  QQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAIN-ELNIK 501

Query: 129  SEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKI 188
             +DT    +  + L   + +   E   + +   +    L  +   +     T+   +SK+
Sbjct: 502  LQDT---NSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKL 558

Query: 189  TVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTN---ELQTLQTDPDVHRNGKYD 245
                      E+L     S  + ++EL+  H+ EV  TN   +L+ L+ + +   +   +
Sbjct: 559  NEAHKSLSTVEDLKAEIVSASESRKELELKHEAEV--TNYKIKLEMLEKEKNAVLDRMAE 616

Query: 246  MSPIHQDKMN----FIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCR 301
                  +++     F  EE L   L ED++ +    +E L   L           +H+ +
Sbjct: 617  SQEAELERLRTQLLFSHEEELS-KLKEDLEIEHRINIEKLKDNL----------GIHYKQ 665

Query: 302  KCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQ 361
            +   L ++EM +  +  +  K+  IT +N   L+  S++     S ++    EM  +  +
Sbjct: 666  QIDGL-QNEMSQKIETMQFEKDNLITKQNQLILEI-SKLKDLQQSLVNSKSEEMTLQINE 723

Query: 362  PFLVKQGSIISENEKTS-KVNSVTEQCVAKIQYLQNYLKESVQ-IQKKVMELESENLNLK 419
              L K+  I+ + EK    +    ++   K + L+  +KE    +Q+K  +LE+EN  LK
Sbjct: 724  --LQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILK 781

Query: 420  SKMKPL-----IFTTQSLIQKV---ETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEF 471
             + K L     I T  S  +++   ++ + + K+ V EK  I+  + + E+  ++C++  
Sbjct: 782  DEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKE-IEILIEENEDLKQQCIQLN 840

Query: 472  KKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQ----SDMAIVNNEN 527
            ++I  + N      K  E    +L  E   +++  D L+  ++K +    S +  +N E 
Sbjct: 841  EEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL 900

Query: 528  NRMSIEMEAMKTNILLIQDEK----------EMLEKKTHQLL-------KEK-------S 563
            +   I    +K    +  ++K          E++EK T +L+       +EK       S
Sbjct: 901  HLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS 960

Query: 564  SLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMER 623
             L  +LK+   EI  L E+ +  K E+       E V      LE  +  + A       
Sbjct: 961  DLSEQLKQKHGEISFLNEEVKSLKQEK-------EQVSLRCRELEIIINHNRA------- 1006

Query: 624  EIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKT--DNQIL 681
              EN+Q+   T   + L  +    S  +  + S+S++ K     SK+++E K   +N  +
Sbjct: 1007 --ENVQSC-DTQVSSLLDGVVTMTSRGA--EGSVSKVNKSFGEESKIMVEDKVSFENMTV 1061

Query: 682  KEELKKHSQENIKFENSISRLTEDKILLENYVRSIE-NERDTLEFEMRHLQRE 733
             EE K   QE +  ++  S      +  E+ +R+ + +E D L+ E+  L+ E
Sbjct: 1062 GEESK---QEQLILDHLPS------VTKESSLRATQPSENDKLQKELNVLKSE 1105



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 149/833 (17%), Positives = 334/833 (40%), Gaps = 134/833 (16%)

Query: 12   EVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQQLESFQALRM 71
            E +S L  A K L++ E +K    S +E    +  E +++ ++ +   + +LE  +  + 
Sbjct: 553  EQESKLNEAHKSLSTVEDLKAEIVSASE----SRKELELKHEAEVTNYKIKLEMLEKEKN 608

Query: 72   QTLQNVSMPTENQEENLSMEK--SHHFEDSKTLHSVE-------EKLSGDSVNSLPQSVN 122
              L  ++   E + E L  +   SH  E SK    +E       EKL  +      Q ++
Sbjct: 609  AVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQID 668

Query: 123  VPSQIHSEDTLTLRTSTDNL---SSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQAD 179
                  S+   T++   DNL    + +I+  S+  D+ ++  N      T   N + +  
Sbjct: 669  GLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEI 728

Query: 180  TVILDKSK-------------ITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALT 226
             ++  + K             +    L+    E  +D+     Q++ E          L 
Sbjct: 729  EILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAE-------NSILK 781

Query: 227  NELQTLQTDPDVHRNGKYDMSPIHQDK----MNFIKEENLDG----------NLNEDIKS 272
            +E +TL+    +H       +P+ Q++    ++ IK ++ D             NED+K 
Sbjct: 782  DEKKTLEDMLKIH-------TPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQ 834

Query: 273  KRISELEALVKKLLPFRETVSKFHVHFCRKCKKLS--------------KSEMHRGKKNE 318
            + I   E + K+   F      F V++    ++ +              K E+    K +
Sbjct: 835  QCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLK 894

Query: 319  KNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEK-- 376
              N+E+ +   N T +K  S V     +F+ +T    +  E+    + +   +++ EK  
Sbjct: 895  ALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLE 954

Query: 377  -TSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQK 435
             + +++ ++EQ   K   + ++L E V    K ++ E E ++L+ +   +I    +  + 
Sbjct: 955  LSQRLSDLSEQLKQKHGEI-SFLNEEV----KSLKQEKEQVSLRCRELEIIIN-HNRAEN 1008

Query: 436  VETYEKQLKNLVEEKSTIQSKLSK--TEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNI 493
            V++ + Q+ +L++   T+ S+ ++    + +K   +E K ++      +      E K  
Sbjct: 1009 VQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQE 1068

Query: 494  QLSLEKQQMMEALDQLK----SKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLI----- 544
            QL L+    +     L+    S+  K Q ++ ++ +E N + ++MEA +  + L+     
Sbjct: 1069 QLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHV 1128

Query: 545  ---------QDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKE------------ 583
                     + +K +   K   +  ++  +    K  QLE+  +K +E            
Sbjct: 1129 DQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLI 1188

Query: 584  -RLAKTEQE-------TLLQIIETVKDEKLNLETTLQE-STAARQIMEREIENIQTYQST 634
             +L K   E       TL  ++       L  E   ++   +   I E E   +Q Y+  
Sbjct: 1189 GKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYE 1248

Query: 635  AEE------NFLQEIKNAKSEASIYKNSLSEI------GKECEMLSKMVMETKTDNQILK 682
             ++        L ++    ++  + +  LS+I      G + E   + + + +T+   + 
Sbjct: 1249 VQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIH 1308

Query: 683  EELKKHSQENIKFENSISRLTE-DKILLENYVRSIENERDTLEFEMRHLQREY 734
             ++      ++  ++ +S L + +K  LE  V+ +E+   +L+ +++  ++ Y
Sbjct: 1309 SQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 108/562 (19%), Positives = 240/562 (42%), Gaps = 98/562 (17%)

Query: 258 KEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKN 317
           +++ ++ +  E+I+ K  + +E L  K++   +   +         K L + +    +KN
Sbjct: 312 QDKKVENSNKEEIQEKE-TIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKN 370

Query: 318 EK-NNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEK 376
           ++  N ++ +T     + +    + +   +  +  K   KD + +  +V++     E E 
Sbjct: 371 QEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQR----MEQET 426

Query: 377 TSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLN-LKSKMKPLIFTTQSLIQK 435
             K+    EQ  A++  +  Y ++ VQ++++++      +  +K++ K  +         
Sbjct: 427 QRKL----EQLRAELDEM--YGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSN 480

Query: 436 VETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQL 495
           +   E Q+K +    + +  KL  T    ++  +E   I+ +   LQ Q + L E   +L
Sbjct: 481 ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVE---EL 537

Query: 496 SLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKK- 554
           S  ++Q+  A   +  +E K         NE ++    +E +K  I+   + ++ LE K 
Sbjct: 538 SFSREQIQRARQTIAEQESKL--------NEAHKSLSTVEDLKAEIVSASESRKELELKH 589

Query: 555 ----------THQLLKEKSSLGNELKESQ-LEIIQLK------EKERLAKTE-------- 589
                        L KEK+++ + + ESQ  E+ +L+       +E L+K +        
Sbjct: 590 EAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHR 649

Query: 590 ---------------------QETLLQIIETVKDEKLNLETTLQE---STAARQIMEREI 625
                                Q  + Q IET++ EK NL T   +     +  + +++ +
Sbjct: 650 INIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSL 709

Query: 626 ENIQTYQSTAEENFLQE----IKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTD---- 677
            N ++ + T + N LQ+    ++  + E    +  + E+  + E+L K + E + D    
Sbjct: 710 VNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEK 769

Query: 678 -------NQILKEELKKHSQENIKFENSISRLTEDKILLENYVRS------IENERDTLE 724
                  N ILK+E KK  ++ +K    +S+  E++++  + ++S       E E + L 
Sbjct: 770 FAQLEAENSILKDE-KKTLEDMLKIHTPVSQ--EERLIFLDSIKSKSKDSVWEKEIEILI 826

Query: 725 FEMRHLQREYLSLSDKICNQHN 746
            E   L+++ + L+++I  Q N
Sbjct: 827 EENEDLKQQCIQLNEEIEKQRN 848



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 158/805 (19%), Positives = 315/805 (39%), Gaps = 141/805 (17%)

Query: 4    EKQHRE--EDEVDSVLLSASKI------LNSSEGVKESGCSDTEYGCIAESENQIQPQSA 55
            EKQ++E  E+EV  V++S S        L+   G KE+  S  +   + + E     +  
Sbjct: 1433 EKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMK 1492

Query: 56   LKVLQQQLESFQALRMQTLQNVSMPTENQEEN-----LSMEKSHHFEDSK--TLHSVEEK 108
            L   Q   ++F+ + ++  +     ++   E+     LS    H   +SK   L   EE 
Sbjct: 1493 LSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEM 1552

Query: 109  LSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLP 168
             S D    + QS      IH E +++   ++  L  N         ++++ Y    +   
Sbjct: 1553 FSKDKTFIVRQS------IHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATE 1606

Query: 169  TAPPNVMSQADTVILDKS-------KITVPFLKHGFCENLDDICHSIKQMKEEL----QK 217
                  M Q +    D+        ++     +    +N + +    + + EEL    Q 
Sbjct: 1607 LLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQL 1666

Query: 218  SHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISE 277
            S  G   L  EL+   T     +NG  +   + +      KE+ LD    ED+  + +S 
Sbjct: 1667 SLAGREKLCCELRNSSTQT---QNGNENQGEVEEQTF---KEKELDRK-PEDVPPEILSN 1719

Query: 278  ---------------LEALVKKLLPFRETVSKFHVHFCRKCKK-------LSKSEMHRGK 315
                           L  +VK      ET+ +  +    +  K       + +SE     
Sbjct: 1720 ERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASV 1779

Query: 316  KNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQG----SII 371
            K+  + +   +T ++I      S +PR  ++   +   E  +  ++  LV+ G     I 
Sbjct: 1780 KSCVHEEHTRVTDESIPSYS-GSDMPRNDINMWSKVTEEGTELSQR--LVRSGFAGTEID 1836

Query: 372  SENEK-----TSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLI 426
             ENE+     +S++ +  E+ +  I    + L+ +   Q ++M    E+   K +     
Sbjct: 1837 PENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMR---ESFRQKQE----- 1888

Query: 427  FTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNK 486
              T+SL       +++L+  + E+S  + +L+         L + + +I  Y       K
Sbjct: 1889 -ATESL-----KCQEELRERLHEESRAREQLAVE-------LSKAEGVIDGY----ADEK 1931

Query: 487  TLEEKNIQLSLEKQQMMEALDQ----LKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNI- 541
            TL E+ IQ   EK  +++ L+Q      ++  + +++   +  E   +S + EAMK    
Sbjct: 1932 TLFERQIQ---EKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAG 1988

Query: 542  -----LLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQI 596
                 LL + EK M EK   Q   EK     + +   LEI   ++  R  + EQE     
Sbjct: 1989 PVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK---- 2044

Query: 597  IETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNS 656
                        T L +     Q +E+++E ++ +         ++  + + E  +++  
Sbjct: 2045 -----------NTELMDLRQQNQALEKQLEKMRKFLD-------EQAIDREHERDVFQQE 2086

Query: 657  LSEIGKECEMLSKM--VMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVR 714
            + ++ ++ +++ +   + E +T      E+L  H +E     +  S L   K  L+  ++
Sbjct: 2087 IQKLEQQLKVVPRFQPISEHQTRE---VEQLANHLKEK---TDKCSELLLSKEQLQRDIQ 2140

Query: 715  SIENERDTLEFEMRHLQREYLSLSD 739
                E + LEF +R L++  L  +D
Sbjct: 2141 ERNEEIEKLEFRVRELEQALLVSAD 2165



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 77/391 (19%), Positives = 159/391 (40%), Gaps = 68/391 (17%)

Query: 412 ESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEF 471
           E E LN + +   + + T+ L Q+++ +E  +K      + + + L +      E ++EF
Sbjct: 170 EIEELNRELEEMRVTYGTEGL-QQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREF 228

Query: 472 KKIISKYNVLQGQ-----------NKTLEEKNIQLSLEKQQMMEALDQLKSKEH------ 514
            ++  +   LQ Q           N T       L   KQQ++    QL+ ++H      
Sbjct: 229 LELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQ 288

Query: 515 KTQSDMAI-------------------VNNENNRMSIEMEAM--KTNILLIQDEKEMLEK 553
           K + D  +                   V N N     E E +  + N  +I++EK+ LE 
Sbjct: 289 KKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLEL 348

Query: 554 KTH---------QLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEK 604
           K           +L ++      E+K  +LE+   K+KER +  E + L+  +E +  +K
Sbjct: 349 KDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEEL--QK 406

Query: 605 LNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSE------ASIYKNSLS 658
            N + +  E+   +++ +     ++  ++  +E + Q+I   K E      A + +    
Sbjct: 407 RNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTR 466

Query: 659 EIGKECEMLSKMVMETKTDNQI---------LKEELKKHSQENIKFENSISRLTEDKILL 709
             G+    L      T  ++QI         L  +L+  + +  K +  +  + E+K  L
Sbjct: 467 HKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCAL 526

Query: 710 ENYVRSIENERDTLEFEMRHLQREYLSLSDK 740
           +   R +E+  + L F    +QR   +++++
Sbjct: 527 Q---RQLEDLVEELSFSREQIQRARQTIAEQ 554



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 137/722 (18%), Positives = 297/722 (41%), Gaps = 55/722 (7%)

Query: 30   VKESGCS-DTEYGCIAESENQIQPQSALKVLQ-QQLESFQALRMQTLQNVSMPTENQEEN 87
            VK +G   + +  C +E   +I  Q   K+ + Q+L + + L M++       T  +E  
Sbjct: 2799 VKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHY 2858

Query: 88   LSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNII 147
            ++++     E+  TL +V + L     +S+P+  +  S  +    +    S  +    I 
Sbjct: 2859 VAVQLLK--EECGTLKAVIQCLRSKEGSSIPELAH--SDAYQTREICSSDSGSDWGQGIY 2914

Query: 148  IHPSENSDILKNYNNFYRFLPTAP-PNVMSQADTVILDKSKITVPFLKHGFCENLDDICH 206
            +  S+  DI            T   P  +      + ++    +   +  + +  D   H
Sbjct: 2915 LTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGED---H 2971

Query: 207  SIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGK-YDMSPIHQDKMNFIKEENLDGN 265
            SI+Q+ E   +     +   + L+ L T   + R  + YD S  H+   ++  E  L   
Sbjct: 2972 SIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLA-- 3029

Query: 266  LNEDIKSKRI-------SELEAL-----VKKLLPFRETVSKFHVHFCRKCKKLSKSEMHR 313
            L +    +R        +EL AL     V  L    + + +  V +    + L K++  R
Sbjct: 3030 LQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKAD-RR 3088

Query: 314  GKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDK--ERQPFLVKQGSII 371
               +E       + G+ IT LK      + +   L+    + + +  E Q  L       
Sbjct: 3089 SLLSEIQALHAQMNGRKIT-LKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRA 3147

Query: 372  SE-NEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKK-VMELESENLNLKSKMKPLIFTT 429
            +E  E+ S    V  +  +++   +  L+ +++ Q K + ELE+  L +K K   +    
Sbjct: 3148 TELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLN 3207

Query: 430  QSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLE 489
             +L  + +   +    L +EK+    KL ++EE  KE L++ K        L+ Q +   
Sbjct: 3208 DTLASEQKKSRELQWALEKEKA----KLGRSEERDKEELEDLKFS------LESQKQRNL 3257

Query: 490  EKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKE 549
            + N+ L  +KQ + E+  +++S+     + ++     N  + + +E+ K  I  +    +
Sbjct: 3258 QLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLD 3317

Query: 550  MLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLET 609
              E++ H  L+     G        E + LKE ++  + +   +++++   +  KL+   
Sbjct: 3318 R-ERELHAQLQSSDGTGQSRPPLPSEDL-LKELQKQLEEKHSRIVELLNETEKYKLDSLQ 3375

Query: 610  TLQESTAARQIMEREIENIQTYQSTAEENFLQ---EIKNAKSEASIYKNSLSEIGKECEM 666
            T Q+    RQ+  + ++  Q   +  ++   +   ++++ + +    +  + ++  E + 
Sbjct: 3376 TRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQR 3435

Query: 667  LSKMVMETKTDNQILKEELKKHSQ----ENIKFENSISRLTEDKILLENYVRSIENERDT 722
            L  ++ E +   Q L+ E K+ S+    +N+  E +   LT D+    N+V   + E +T
Sbjct: 3436 LQGIMQEFQ--KQELEREEKRESRRILYQNLN-EPTTWSLTSDR--TRNWVLQQKIEGET 3490

Query: 723  LE 724
             E
Sbjct: 3491 KE 3492



 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 146/805 (18%), Positives = 302/805 (37%), Gaps = 157/805 (19%)

Query: 4    EKQHREEDEVDSVLLSASKILNSSEGVKESGCSDT------EYGCIAESENQIQPQSALK 57
            EK      E++  LL ++      E  K  G  +       E    AE +   + +  + 
Sbjct: 2147 EKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEIT 2206

Query: 58   VLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSL 117
             L++QLE F+    + L+N +   +     L ++K       + L   E KL  D +  L
Sbjct: 2207 NLEEQLEQFR----EELENKNEEVQQLHMQLEIQKKESTTRLQELEQ-ENKLFKDDMEKL 2261

Query: 118  PQSVNVPSQIHSEDTLTL-----------RTSTDNLSSNII-----IHPSENSDILKNYN 161
              ++     + ++D   L               D L+  +      +  + ++ +++  N
Sbjct: 2262 GLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKN 2321

Query: 162  NFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEEL----QK 217
               R L T    +MS  + V  ++             E ++ +   I+++++EL    QK
Sbjct: 2322 ELIRDLETQIECLMSDQECVKRNRE------------EEIEQLNEVIEKLQQELANIGQK 2369

Query: 218  SHDGEVALTNELQTLQTDPDVHRNGKYDMSP---IHQDKMNFIKEENLDGNLNEDIKSKR 274
            +     +L+ E  +L+   DV    K  +        ++M F+K    + N        +
Sbjct: 2370 TSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNF-------K 2422

Query: 275  ISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDL 334
            +++L   +  L   RE+V K                           + IP    N+   
Sbjct: 2423 MNQLTQELFSLKRERESVEKI--------------------------QSIPENSVNVAID 2456

Query: 335  KFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYL 394
                  P   +     T+  +K  E Q +         EN K S +N  T          
Sbjct: 2457 HLSKDKPELEVVL---TEDALKSLENQTYFKS----FEENGKGSIINLETR--------- 2500

Query: 395  QNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQ 454
               L+    +  K +EL      +K   +   F T+ L +K+   +K ++  V      Q
Sbjct: 2501 --LLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQ 2558

Query: 455  SKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEH 514
             +L   +EY+K C                 N+T+  +  + +++       L+QL  +E 
Sbjct: 2559 IQLEAVQEYAKFC---------------QDNQTISSEPERTNIQN------LNQL--RED 2595

Query: 515  KTQSDMAIVNNENNRMSIEMEAMKTNILLIQD-----EKEMLEKKTHQLLKEKSSLGNEL 569
            +  SD++ +    + +  ++  M T+++L ++     EK +LEK+   L  +K   GNE 
Sbjct: 2596 ELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEK 2655

Query: 570  KESQLEIIQLKEKERLAKT--------EQETLLQIIETVKDEKLNLETTLQESTAARQIM 621
            K+ + E  +  +   + KT        E+      +E ++ E +  +  L       + +
Sbjct: 2656 KQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKL 2715

Query: 622  EREIENIQTYQSTAEENFLQ---EIKNAKSEASIY----KNSLSEIGKECEM------LS 668
            + E+   +T  ++ +++  Q    +  AK + SI     +  + E  K C        LS
Sbjct: 2716 QEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLS 2775

Query: 669  KMV-------METKTDNQILKEELKKHS-QENIKFENSISRLTEDKILLENYVRSIENER 720
            K +       ++  + NQ  +  +K    Q N++ E S   +TE   ++  +   IE  +
Sbjct: 2776 KSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTE---IISQFTEKIEKMQ 2832

Query: 721  DTLEFEMRHLQREYLSLSDKICNQH 745
            +    E+  ++  ++S ++ +  +H
Sbjct: 2833 ELHAAEILDMESRHISETETLKREH 2857



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 67/317 (21%), Positives = 146/317 (46%), Gaps = 44/317 (13%)

Query: 430  QSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLE 489
            +SL+ +++    Q+      K T++ +  ++E+ S+E L+        YN+ Q Q++ LE
Sbjct: 3088 RSLLSEIQALHAQMNG---RKITLKRE-QESEKPSQELLE--------YNIQQKQSQMLE 3135

Query: 490  EKNIQLSLEKQQMMEALDQL----------KSKEHKTQSDMAIVNNENNRMSIEMEAMKT 539
             + ++LS  K +  E  +QL          KS+  +T+ ++       ++   E+EA + 
Sbjct: 3136 MQ-VELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRL 3194

Query: 540  NILLIQDEKEMLEKKTHQLLKEKSSLGNELKES-QLEIIQLKEKERLAKTEQETLLQIIE 598
             +    DE  +L            +L +E K+S +L+    KEK +L ++E+       E
Sbjct: 3195 EVKDKTDEVHLL----------NDTLASEQKKSRELQWALEKEKAKLGRSEERDK----E 3240

Query: 599  TVKDEKLNLETTLQESTAARQIMEREIENI-QTYQSTAEENFLQEIKNAKSEASIYKNSL 657
             ++D K +LE+  Q +     ++E++ + + ++ Q    +  L + + ++ +    +  +
Sbjct: 3241 ELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQV 3300

Query: 658  ---SEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVR 714
               SE  +  EM S +  E +   Q+   +    S+  +  E+ +  L   K L E + R
Sbjct: 3301 LLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKEL--QKQLEEKHSR 3358

Query: 715  SIENERDTLEFEMRHLQ 731
             +E   +T ++++  LQ
Sbjct: 3359 IVELLNETEKYKLDSLQ 3375


>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
          Length = 1088

 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 161/819 (19%), Positives = 322/819 (39%), Gaps = 152/819 (18%)

Query: 43  IAESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMPT------ENQEENLSMEKSHHF 96
           + + ENQ   Q  ++ LQ +L   + L     Q+ S  T      E  EEN     + H 
Sbjct: 217 VVQEENQ-HMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHE 275

Query: 97  EDSKTLHSVEEKLSG---------DSVNSLPQSVNVPSQIHSEDTLTLRTSTDN------ 141
             +K L  + + L            ++N+  +S+    ++     L+ + + ++      
Sbjct: 276 RQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRR 335

Query: 142 -LSSNIIIHPSENSDILKNYNN------FYRFLPTAPPNVMSQADTVILDKSKITVPFLK 194
              + + +H  E+    K   N       +R    AP +  ++A   +++     +  ++
Sbjct: 336 LAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSME 395

Query: 195 HGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRN-GKYDMSPIHQDK 253
            G           ++ ++EE+Q         T E +      +V+R+  K+  + I Q K
Sbjct: 396 RG-----------LRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVK 444

Query: 254 MNFIKEEN--------LDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKK 305
               +++         L+   N+   SK+   +E L + L    +  +           +
Sbjct: 445 QELSRKDTELLALQTKLETLTNQFSDSKQ--HIEVLKESLTAKEQRAAILQTEVDALRLR 502

Query: 306 LSKSEMHRGKKNEKNN---KEIPITGKNITDLKFHSRVPRYTLSFL----DQTKHEMKDK 358
           L + E    KK ++     +E       I DLK    V    ++ L    +  + +++DK
Sbjct: 503 LEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDK 562

Query: 359 ERQPFLVKQG--SIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENL 416
           E+Q   +K+   S+ ++   T    +  E+ +A+ +     LKE    Q+   E E +  
Sbjct: 563 EKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKE----QRDRDEREKQ-- 616

Query: 417 NLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIIS 476
                            ++++ Y+K LK+L E+ S +Q  LS+ E    +  +    + S
Sbjct: 617 -----------------EEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLAS 659

Query: 477 KYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEA 536
                  + KTLE   I L  +K++ ++   QLK K H+     A+    +  MS  ++ 
Sbjct: 660 SGLKKDSRLKTLE---IALEQKKEECLKMESQLK-KAHEA----ALEARASPEMSDRIQH 711

Query: 537 MKTNILLIQDEKEMLEKKTHQLL--------------KEKSSLGNELKESQLEIIQLKEK 582
           ++  I   +DE    + +  +LL              K+ + L  ++K+   ++  LK K
Sbjct: 712 LEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHK 771

Query: 583 ERLAKTEQETLL---------------QIIETV--KDEKL-NLETTLQES---TAARQIM 621
           E++ K +   +L               Q+ +++  KD+++  LE  L+ES   TA R+++
Sbjct: 772 EQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMV 831

Query: 622 EREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQIL 681
             + E+ +T      E  L  ++  K E    K  LS          + + E +T    L
Sbjct: 832 LAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSS-------TQQSLAEKETHLTNL 884

Query: 682 KEELKKHSQENIKFEN-----SISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLS 736
           + E +KH +E ++ +      +IS    +  LLE     + + +   + E+  L+RE   
Sbjct: 885 RAERRKHLEEVLEMKQEALLAAISEKDANIALLE-----LSSSKKKTQEEVAALKRE--- 936

Query: 737 LSDKICNQHNDPSKTTYISRREKFHFDNYTHEDTSSPQS 775
             D++  Q    ++      R K   DNY  +   S  S
Sbjct: 937 -KDRLVQQLKQQTQ-----NRMKLMADNYEDDHFKSSHS 969



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 121/615 (19%), Positives = 245/615 (39%), Gaps = 71/615 (11%)

Query: 1   MSPEKQHRE-EDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVL 59
           M  E+ HR  E+  DS   + +K L +   +K+S  S  E G + + E +IQ   +   L
Sbjct: 359 MLREEMHRRFENAPDS---AKTKALQTVIEMKDSKISSMERG-LRDLEEEIQMLKSNGAL 414

Query: 60  QQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQ 119
             +    +  +M+  ++ S   +N+   +  E S    +   L +  E L+    +S   
Sbjct: 415 STEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQH 474

Query: 120 SVNVPSQIHSED--TLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQ 177
              +   + +++     L+T  D L   +    +  +   K   +      T    +   
Sbjct: 475 IEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDL 534

Query: 178 ADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPD 237
            D + + + K+ V             +   I+ ++E+L+       +L   +++LQ D  
Sbjct: 535 KDMLDVKERKVNV-------------LQKKIENLQEQLRDKEKQMSSLKERVKSLQADTT 581

Query: 238 VHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHV 297
                   +     +K   I  E L    + D + K+  E++   K L   +E VS    
Sbjct: 582 NTDTALTTLEEALAEKERTI--ERLKEQRDRDEREKQ-EEIDNYKKDLKDLKEKVSLLQG 638

Query: 298 HFCRK------CKKLSKSEMHRGKKNEKNNK--EIPITGKNITDLKFHSRVPRYTLSFLD 349
               K       K+ + S    G K +   K  EI +  K    LK  S++ +   + L+
Sbjct: 639 DLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALE 698

Query: 350 -QTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKV 408
            +   EM D+ +      +  I    +++SK  +  ++ +  ++ ++N   E     KK+
Sbjct: 699 ARASPEMSDRIQH----LEREITRYKDESSKAQAEVDRLLEILKEVEN---EKNDKDKKI 751

Query: 409 MELESENLNLKSKMKPLIFTTQ----SLIQKVETYEKQLKNLVEEKSTIQSKLSKTE--- 461
            ELE +  +   K+  L    Q       Q +E   ++  NL +    +Q  L K +   
Sbjct: 752 AELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRI 811

Query: 462 EYSKECLKEFKKIISKYNVLQGQN---KTLEEKNIQ-LSLEKQQMMEALDQLKSKEHKTQ 517
           E  +E L+E  +I ++  ++  Q    +T  EK ++ L +  +++ + L+ +K+K   TQ
Sbjct: 812 EELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQ 871

Query: 518 SDMA-----IVNNENNR-------MSIEMEAM-------KTNILLIQ--DEKEMLEKKTH 556
             +A     + N    R       + ++ EA+         NI L++    K+  +++  
Sbjct: 872 QSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVA 931

Query: 557 QLLKEKSSLGNELKE 571
            L +EK  L  +LK+
Sbjct: 932 ALKREKDRLVQQLKQ 946


>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
          Length = 3899

 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 157/773 (20%), Positives = 317/773 (41%), Gaps = 108/773 (13%)

Query: 19   SASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQQLESFQALRMQTLQNVS 78
            S  K   SSE +K+   +  E       ++Q +     ++ Q+     + LR +  +   
Sbjct: 383  SKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYG 442

Query: 79   MPTENQEENLSMEKSHHFEDSKTLHSVEEK----------LSGDSVNSLPQSVNVPSQIH 128
                  ++ L  +     E+ KT H  E +          ++ D +  +  ++N    I 
Sbjct: 443  QQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAIN-ELNIK 501

Query: 129  SEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKI 188
             +DT    +  + L   + +   E   + +   +    L  +   +     T+   +SK+
Sbjct: 502  LQDT---NSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKL 558

Query: 189  TVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTN---ELQTLQTDPDVHRNGKYD 245
                      E+L     S  + ++EL+  H+ EV  TN   +L+ L+ + +   +   +
Sbjct: 559  NEAHKSLSTVEDLKAEIVSASESRKELELKHEAEV--TNYKIKLEMLEKEKNAVLDRMAE 616

Query: 246  MSPIHQDKMN----FIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCR 301
                  +++     F  EE L   L ED++ +    +E L   L           +H+ +
Sbjct: 617  SQEAELERLRTQLLFSHEEELS-KLKEDLEIEHRINIEKLKDNL----------GIHYKQ 665

Query: 302  KCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQ 361
            +   L ++EM +  +  +  K+  IT +N   L+  S++     S ++    EM  +  +
Sbjct: 666  QIDGL-QNEMSQKIETMQFEKDNLITKQNQLILEI-SKLKDLQQSLVNSKSEEMTLQINE 723

Query: 362  PFLVKQGSIISENEKTS-KVNSVTEQCVAKIQYLQNYLKESVQ-IQKKVMELESENLNLK 419
              L K+  I+ + EK    +    ++   K + L+  +KE    +Q+K  +LE+EN  LK
Sbjct: 724  --LQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILK 781

Query: 420  SKMKPL-----IFTTQSLIQKV---ETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEF 471
             + K L     I T  S  +++   ++ + + K+ V EK  I+  + + E+  ++C++  
Sbjct: 782  DEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKE-IEILIEENEDLKQQCIQLN 840

Query: 472  KKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQ----SDMAIVNNEN 527
            ++I  + N      K  E    +L  E   +++  D L+  ++K +    S +  +N E 
Sbjct: 841  EEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL 900

Query: 528  NRMSIEMEAMKTNILLIQDEK----------EMLEKKTHQLL-------KEK-------S 563
            +   I    +K    +  ++K          E++EK T +L+       +EK       S
Sbjct: 901  HLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS 960

Query: 564  SLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMER 623
             L  +LK+   EI  L E+ +  K E+       E V      LE  +  + A       
Sbjct: 961  DLSEQLKQKHGEISFLNEEVKSLKQEK-------EQVSLRCRELEIIINHNRA------- 1006

Query: 624  EIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKT--DNQIL 681
              EN+Q+   T   + L  +    S  +  + S+S++ K     SK+++E K   +N  +
Sbjct: 1007 --ENVQSC-DTQVSSLLDGVVTMTSRGA--EGSVSKVNKSFGEESKIMVEDKVSFENMTV 1061

Query: 682  KEELKKHSQENIKFENSISRLTEDKILLENYVRSIE-NERDTLEFEMRHLQRE 733
             EE K   QE +  ++  S      +  E+ +R+ + +E D L+ E+  L+ E
Sbjct: 1062 GEESK---QEQLILDHLPS------VTKESSLRATQPSENDKLQKELNVLKSE 1105



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 116/554 (20%), Positives = 241/554 (43%), Gaps = 75/554 (13%)

Query: 202  DDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEEN 261
            DD+   +K ++ ++++     + L  E  T   D    R     +    +    F+ E+ 
Sbjct: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDL---RQQNQALEKQLEKMRKFLDEQA 2073

Query: 262  LDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKK----- 316
            +D     D+  + I +LE  +K ++P  + +S+   H  R+ ++L+     +  K     
Sbjct: 2074 IDREHERDVFQQEIQKLEQQLK-VVPRFQPISE---HQTREVEQLANHLKEKTDKCSELL 2129

Query: 317  --NEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISEN 374
               E+  ++I    + I  L+F  RV     + L + +      E +P L  +  + +E 
Sbjct: 2130 LSKEQLQRDIQERNEEIEKLEF--RVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAER 2187

Query: 375  E----KTSKVNSVTEQCVAKIQYLQNYLKE------SVQIQKK-----VMELESENLNLK 419
            +    K  ++ ++ EQ     + L+N  +E       ++IQKK     + ELE EN   K
Sbjct: 2188 DAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFK 2247

Query: 420  SKMKPLIFTTQSLIQKVETYEKQLKNLVEEK--STIQSKLSKTEEYSKEC--LKEFKKII 475
              M+ L       I++ +    Q ++++  K    IQ K  + ++ +++   L++  KI 
Sbjct: 2248 DDMEKLGLA----IKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKIT 2303

Query: 476  SKYNVLQGQNKTLEEKNIQLSL-------EKQQMMEALDQLKSKEHKTQSDMAIVNNENN 528
            +   V++ +N+ + +   Q+          K+   E ++QL     K Q ++A +  + +
Sbjct: 2304 TDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTS 2363

Query: 529  R----MSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKER 584
                 +S E +++K  + ++  EK  LE++     +E + + N LKE+  ++ QL ++  
Sbjct: 2364 MNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELF 2423

Query: 585  LAKTEQETLLQI-----------IETVKDEKLNLETTLQESTAARQIMEREIENIQTYQS 633
              K E+E++ +I           I+ +  +K  LE  L E         + +EN QTY  
Sbjct: 2424 SLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDAL------KSLEN-QTYFK 2476

Query: 634  TAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENI 693
            + EEN    I N ++     ++++S    E     K + + +   Q   E L+K      
Sbjct: 2477 SFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQK------ 2530

Query: 694  KFENSISRLTEDKI 707
            K  N + ++ E+K+
Sbjct: 2531 KIVN-LQKIVEEKV 2543



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 149/833 (17%), Positives = 334/833 (40%), Gaps = 134/833 (16%)

Query: 12   EVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQQLESFQALRM 71
            E +S L  A K L++ E +K    S +E    +  E +++ ++ +   + +LE  +  + 
Sbjct: 553  EQESKLNEAHKSLSTVEDLKAEIVSASE----SRKELELKHEAEVTNYKIKLEMLEKEKN 608

Query: 72   QTLQNVSMPTENQEENLSMEK--SHHFEDSKTLHSVE-------EKLSGDSVNSLPQSVN 122
              L  ++   E + E L  +   SH  E SK    +E       EKL  +      Q ++
Sbjct: 609  AVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQID 668

Query: 123  VPSQIHSEDTLTLRTSTDNL---SSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQAD 179
                  S+   T++   DNL    + +I+  S+  D+ ++  N      T   N + +  
Sbjct: 669  GLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEI 728

Query: 180  TVILDKSK-------------ITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALT 226
             ++  + K             +    L+    E  +D+     Q++ E          L 
Sbjct: 729  EILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAE-------NSILK 781

Query: 227  NELQTLQTDPDVHRNGKYDMSPIHQDK----MNFIKEENLDG----------NLNEDIKS 272
            +E +TL+    +H       +P+ Q++    ++ IK ++ D             NED+K 
Sbjct: 782  DEKKTLEDMLKIH-------TPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQ 834

Query: 273  KRISELEALVKKLLPFRETVSKFHVHFCRKCKKLS--------------KSEMHRGKKNE 318
            + I   E + K+   F      F V++    ++ +              K E+    K +
Sbjct: 835  QCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLK 894

Query: 319  KNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEK-- 376
              N+E+ +   N T +K  S V     +F+ +T    +  E+    + +   +++ EK  
Sbjct: 895  ALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLE 954

Query: 377  -TSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQK 435
             + +++ ++EQ   K   + ++L E V    K ++ E E ++L+ +   +I    +  + 
Sbjct: 955  LSQRLSDLSEQLKQKHGEI-SFLNEEV----KSLKQEKEQVSLRCRELEIIIN-HNRAEN 1008

Query: 436  VETYEKQLKNLVEEKSTIQSKLSK--TEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNI 493
            V++ + Q+ +L++   T+ S+ ++    + +K   +E K ++      +      E K  
Sbjct: 1009 VQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQE 1068

Query: 494  QLSLEKQQMMEALDQLK----SKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLI----- 544
            QL L+    +     L+    S+  K Q ++ ++ +E N + ++MEA +  + L+     
Sbjct: 1069 QLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHV 1128

Query: 545  ---------QDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKE------------ 583
                     + +K +   K   +  ++  +    K  QLE+  +K +E            
Sbjct: 1129 DQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLI 1188

Query: 584  -RLAKTEQE-------TLLQIIETVKDEKLNLETTLQE-STAARQIMEREIENIQTYQST 634
             +L K   E       TL  ++       L  E   ++   +   I E E   +Q Y+  
Sbjct: 1189 GKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYE 1248

Query: 635  AEE------NFLQEIKNAKSEASIYKNSLSEI------GKECEMLSKMVMETKTDNQILK 682
             ++        L ++    ++  + +  LS+I      G + E   + + + +T+   + 
Sbjct: 1249 VQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIH 1308

Query: 683  EELKKHSQENIKFENSISRLTE-DKILLENYVRSIENERDTLEFEMRHLQREY 734
             ++      ++  ++ +S L + +K  LE  V+ +E+   +L+ +++  ++ Y
Sbjct: 1309 SQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 108/562 (19%), Positives = 240/562 (42%), Gaps = 98/562 (17%)

Query: 258 KEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKN 317
           +++ ++ +  E+I+ K  + +E L  K++   +   +         K L + +    +KN
Sbjct: 312 QDKKVENSNKEEIQEKE-TIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKN 370

Query: 318 EK-NNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEK 376
           ++  N ++ +T     + +    + +   +  +  K   KD + +  +V++     E E 
Sbjct: 371 QEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQR----MEQET 426

Query: 377 TSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLN-LKSKMKPLIFTTQSLIQK 435
             K+    EQ  A++  +  Y ++ VQ++++++      +  +K++ K  +         
Sbjct: 427 QRKL----EQLRAELDEM--YGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSN 480

Query: 436 VETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQL 495
           +   E Q+K +    + +  KL  T    ++  +E   I+ +   LQ Q + L E   +L
Sbjct: 481 ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVE---EL 537

Query: 496 SLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKK- 554
           S  ++Q+  A   +  +E K         NE ++    +E +K  I+   + ++ LE K 
Sbjct: 538 SFSREQIQRARQTIAEQESKL--------NEAHKSLSTVEDLKAEIVSASESRKELELKH 589

Query: 555 ----------THQLLKEKSSLGNELKESQ-LEIIQLK------EKERLAKTE-------- 589
                        L KEK+++ + + ESQ  E+ +L+       +E L+K +        
Sbjct: 590 EAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHR 649

Query: 590 ---------------------QETLLQIIETVKDEKLNLETTLQE---STAARQIMEREI 625
                                Q  + Q IET++ EK NL T   +     +  + +++ +
Sbjct: 650 INIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSL 709

Query: 626 ENIQTYQSTAEENFLQE----IKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTD---- 677
            N ++ + T + N LQ+    ++  + E    +  + E+  + E+L K + E + D    
Sbjct: 710 VNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEK 769

Query: 678 -------NQILKEELKKHSQENIKFENSISRLTEDKILLENYVRS------IENERDTLE 724
                  N ILK+E KK  ++ +K    +S+  E++++  + ++S       E E + L 
Sbjct: 770 FAQLEAENSILKDE-KKTLEDMLKIHTPVSQ--EERLIFLDSIKSKSKDSVWEKEIEILI 826

Query: 725 FEMRHLQREYLSLSDKICNQHN 746
            E   L+++ + L+++I  Q N
Sbjct: 827 EENEDLKQQCIQLNEEIEKQRN 848



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 157/801 (19%), Positives = 313/801 (39%), Gaps = 141/801 (17%)

Query: 4    EKQHRE--EDEVDSVLLSASKI------LNSSEGVKESGCSDTEYGCIAESENQIQPQSA 55
            EKQ++E  E+EV  V++S S        L+   G KE+  S  +   + + E     +  
Sbjct: 1433 EKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMK 1492

Query: 56   LKVLQQQLESFQALRMQTLQNVSMPTENQEEN-----LSMEKSHHFEDSK--TLHSVEEK 108
            L   Q   ++F+ + ++  +     ++   E+     LS    H   +SK   L   EE 
Sbjct: 1493 LSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEM 1552

Query: 109  LSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLP 168
             S D    + QS      IH E +++   ++  L  N         ++++ Y    +   
Sbjct: 1553 FSKDKTFIVRQS------IHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATE 1606

Query: 169  TAPPNVMSQADTVILDKS-------KITVPFLKHGFCENLDDICHSIKQMKEEL----QK 217
                  M Q +    D+        ++     +    +N + +    + + EEL    Q 
Sbjct: 1607 LLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQL 1666

Query: 218  SHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISE 277
            S  G   L  EL+   T     +NG  +   + +      KE+ LD    ED+  + +S 
Sbjct: 1667 SLAGREKLCCELRNSSTQT---QNGNENQGEVEEQTF---KEKELDRK-PEDVPPEILSN 1719

Query: 278  ---------------LEALVKKLLPFRETVSKFHVHFCRKCKK-------LSKSEMHRGK 315
                           L  +VK      ET+ +  +    +  K       + +SE     
Sbjct: 1720 ERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASV 1779

Query: 316  KNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQG----SII 371
            K+  + +   +T ++I      S +PR  ++   +   E  +  ++  LV+ G     I 
Sbjct: 1780 KSCVHEEHTRVTDESIPSYS-GSDMPRNDINMWSKVTEEGTELSQR--LVRSGFAGTEID 1836

Query: 372  SENEK-----TSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLI 426
             ENE+     +S++ +  E+ +  I    + L+ +   Q ++M    E+   K +     
Sbjct: 1837 PENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMR---ESFRQKQE----- 1888

Query: 427  FTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNK 486
              T+SL       +++L+  + E+S  + +L+         L + + +I  Y       K
Sbjct: 1889 -ATESL-----KCQEELRERLHEESRAREQLAVE-------LSKAEGVIDGY----ADEK 1931

Query: 487  TLEEKNIQLSLEKQQMMEALDQ----LKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNI- 541
            TL E+ IQ   EK  +++ L+Q      ++  + +++   +  E   +S + EAMK    
Sbjct: 1932 TLFERQIQ---EKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAG 1988

Query: 542  -----LLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQI 596
                 LL + EK M EK   Q   EK     + +   LEI   ++  R  + EQE     
Sbjct: 1989 PVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK---- 2044

Query: 597  IETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNS 656
                        T L +     Q +E+++E ++ +         ++  + + E  +++  
Sbjct: 2045 -----------NTELMDLRQQNQALEKQLEKMRKFLD-------EQAIDREHERDVFQQE 2086

Query: 657  LSEIGKECEMLSKM--VMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVR 714
            + ++ ++ +++ +   + E +T      E+L  H +E     +  S L   K  L+  ++
Sbjct: 2087 IQKLEQQLKVVPRFQPISEHQTRE---VEQLANHLKEK---TDKCSELLLSKEQLQRDIQ 2140

Query: 715  SIENERDTLEFEMRHLQREYL 735
                E + LEF +R L++  L
Sbjct: 2141 ERNEEIEKLEFRVRELEQALL 2161



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 77/391 (19%), Positives = 159/391 (40%), Gaps = 68/391 (17%)

Query: 412 ESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEF 471
           E E LN + +   + + T+ L Q+++ +E  +K      + + + L +      E ++EF
Sbjct: 170 EIEELNRELEEMRVTYGTEGL-QQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREF 228

Query: 472 KKIISKYNVLQGQ-----------NKTLEEKNIQLSLEKQQMMEALDQLKSKEH------ 514
            ++  +   LQ Q           N T       L   KQQ++    QL+ ++H      
Sbjct: 229 LELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQ 288

Query: 515 KTQSDMAI-------------------VNNENNRMSIEMEAM--KTNILLIQDEKEMLEK 553
           K + D  +                   V N N     E E +  + N  +I++EK+ LE 
Sbjct: 289 KKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLEL 348

Query: 554 KTH---------QLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEK 604
           K           +L ++      E+K  +LE+   K+KER +  E + L+  +E +  +K
Sbjct: 349 KDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEEL--QK 406

Query: 605 LNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSE------ASIYKNSLS 658
            N + +  E+   +++ +     ++  ++  +E + Q+I   K E      A + +    
Sbjct: 407 RNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTR 466

Query: 659 EIGKECEMLSKMVMETKTDNQI---------LKEELKKHSQENIKFENSISRLTEDKILL 709
             G+    L      T  ++QI         L  +L+  + +  K +  +  + E+K  L
Sbjct: 467 HKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCAL 526

Query: 710 ENYVRSIENERDTLEFEMRHLQREYLSLSDK 740
           +   R +E+  + L F    +QR   +++++
Sbjct: 527 Q---RQLEDLVEELSFSREQIQRARQTIAEQ 554



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 137/722 (18%), Positives = 297/722 (41%), Gaps = 55/722 (7%)

Query: 30   VKESGCS-DTEYGCIAESENQIQPQSALKVLQ-QQLESFQALRMQTLQNVSMPTENQEEN 87
            VK +G   + +  C +E   +I  Q   K+ + Q+L + + L M++       T  +E  
Sbjct: 2791 VKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHY 2850

Query: 88   LSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNII 147
            ++++     E+  TL +V + L     +S+P+  +  S  +    +    S  +    I 
Sbjct: 2851 VAVQLLK--EECGTLKAVIQCLRSKEGSSIPELAH--SDAYQTREICSSDSGSDWGQGIY 2906

Query: 148  IHPSENSDILKNYNNFYRFLPTAP-PNVMSQADTVILDKSKITVPFLKHGFCENLDDICH 206
            +  S+  DI            T   P  +      + ++    +   +  + +  D   H
Sbjct: 2907 LTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGED---H 2963

Query: 207  SIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGK-YDMSPIHQDKMNFIKEENLDGN 265
            SI+Q+ E   +     +   + L+ L T   + R  + YD S  H+   ++  E  L   
Sbjct: 2964 SIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLA-- 3021

Query: 266  LNEDIKSKRI-------SELEAL-----VKKLLPFRETVSKFHVHFCRKCKKLSKSEMHR 313
            L +    +R        +EL AL     V  L    + + +  V +    + L K++  R
Sbjct: 3022 LQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKAD-RR 3080

Query: 314  GKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDK--ERQPFLVKQGSII 371
               +E       + G+ IT LK      + +   L+    + + +  E Q  L       
Sbjct: 3081 SLLSEIQALHAQMNGRKIT-LKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRA 3139

Query: 372  SE-NEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKK-VMELESENLNLKSKMKPLIFTT 429
            +E  E+ S    V  +  +++   +  L+ +++ Q K + ELE+  L +K K   +    
Sbjct: 3140 TELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLN 3199

Query: 430  QSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLE 489
             +L  + +   +    L +EK+    KL ++EE  KE L++ K        L+ Q +   
Sbjct: 3200 DTLASEQKKSRELQWALEKEKA----KLGRSEERDKEELEDLKFS------LESQKQRNL 3249

Query: 490  EKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKE 549
            + N+ L  +KQ + E+  +++S+     + ++     N  + + +E+ K  I  +    +
Sbjct: 3250 QLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLD 3309

Query: 550  MLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLET 609
              E++ H  L+     G        E + LKE ++  + +   +++++   +  KL+   
Sbjct: 3310 R-ERELHAQLQSSDGTGQSRPPLPSEDL-LKELQKQLEEKHSRIVELLNETEKYKLDSLQ 3367

Query: 610  TLQESTAARQIMEREIENIQTYQSTAEENFLQ---EIKNAKSEASIYKNSLSEIGKECEM 666
            T Q+    RQ+  + ++  Q   +  ++   +   ++++ + +    +  + ++  E + 
Sbjct: 3368 TRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQR 3427

Query: 667  LSKMVMETKTDNQILKEELKKHSQ----ENIKFENSISRLTEDKILLENYVRSIENERDT 722
            L  ++ E +   Q L+ E K+ S+    +N+  E +   LT D+    N+V   + E +T
Sbjct: 3428 LQGIMQEFQ--KQELEREEKRESRRILYQNLN-EPTTWSLTSDR--TRNWVLQQKIEGET 3482

Query: 723  LE 724
             E
Sbjct: 3483 KE 3484



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 137/759 (18%), Positives = 288/759 (37%), Gaps = 151/759 (19%)

Query: 44   AESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLH 103
            AE +   + +  +  L++QLE F+    + L+N +   +     L ++K       + L 
Sbjct: 2185 AERDAIDRKEKEITNLEEQLEQFR----EELENKNEEVQQLHMQLEIQKKESTTRLQELE 2240

Query: 104  SVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTL-----------RTSTDNLSSNII----- 147
              E KL  D +  L  ++     + ++D   L               D L+  +      
Sbjct: 2241 Q-ENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQ 2299

Query: 148  IHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHS 207
            +  + ++ +++  N   R L T    +MS  + V  ++             E ++ +   
Sbjct: 2300 LKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNRE------------EEIEQLNEV 2347

Query: 208  IKQMKEEL----QKSHDGEVALTNELQTLQTDPDVHRNGKYDMSP---IHQDKMNFIKEE 260
            I+++++EL    QK+     +L+ E  +L+   DV    K  +        ++M F+K  
Sbjct: 2348 IEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNV 2407

Query: 261  NLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKN 320
              + N        ++++L   +  L   RE+V K                          
Sbjct: 2408 LKETNF-------KMNQLTQELFSLKRERESVEKI------------------------- 2435

Query: 321  NKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKV 380
             + IP    N+         P   +     T+  +K  E Q +         EN K S +
Sbjct: 2436 -QSIPENSVNVAIDHLSKDKPELEVVL---TEDALKSLENQTYFKS----FEENGKGSII 2487

Query: 381  NSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYE 440
            N  T             L+    +  K +EL      +K   +   F T+ L +K+   +
Sbjct: 2488 NLETR-----------LLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQ 2536

Query: 441  KQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQ 500
            K ++  V      Q +L   +EY+K C                 N+T+  +  + +++  
Sbjct: 2537 KIVEEKVAAALVSQIQLEAVQEYAKFC---------------QDNQTISSEPERTNIQN- 2580

Query: 501  QMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQD-----EKEMLEKKT 555
                 L+QL  +E +  SD++ +    + +  ++  M T+++L ++     EK +LEK+ 
Sbjct: 2581 -----LNQL--REDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEK 2633

Query: 556  HQLLKEKSSLGNELKESQLEIIQLKEKERLAKT--------EQETLLQIIETVKDEKLNL 607
              L  +K   GNE K+ + E  +  +   + KT        E+      +E ++ E +  
Sbjct: 2634 KLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVAT 2693

Query: 608  ETTLQESTAARQIMEREIENIQTYQSTAEENFLQ---EIKNAKSEASIY----KNSLSEI 660
            +  L       + ++ E+   +T  ++ +++  Q    +  AK + SI     +  + E 
Sbjct: 2694 KAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQES 2753

Query: 661  GKECEM------LSKMV-------METKTDNQILKEELKKHS-QENIKFENSISRLTEDK 706
             K C        LSK +       ++  + NQ  +  +K    Q N++ E S   +TE  
Sbjct: 2754 KKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTE-- 2811

Query: 707  ILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQH 745
             ++  +   IE  ++    E+  ++  ++S ++ +  +H
Sbjct: 2812 -IISQFTEKIEKMQELHAAEILDMESRHISETETLKREH 2849



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 67/317 (21%), Positives = 146/317 (46%), Gaps = 44/317 (13%)

Query: 430  QSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLE 489
            +SL+ +++    Q+      K T++ +  ++E+ S+E L+        YN+ Q Q++ LE
Sbjct: 3080 RSLLSEIQALHAQMNG---RKITLKRE-QESEKPSQELLE--------YNIQQKQSQMLE 3127

Query: 490  EKNIQLSLEKQQMMEALDQL----------KSKEHKTQSDMAIVNNENNRMSIEMEAMKT 539
             + ++LS  K +  E  +QL          KS+  +T+ ++       ++   E+EA + 
Sbjct: 3128 MQ-VELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRL 3186

Query: 540  NILLIQDEKEMLEKKTHQLLKEKSSLGNELKES-QLEIIQLKEKERLAKTEQETLLQIIE 598
             +    DE  +L            +L +E K+S +L+    KEK +L ++E+       E
Sbjct: 3187 EVKDKTDEVHLL----------NDTLASEQKKSRELQWALEKEKAKLGRSEERDK----E 3232

Query: 599  TVKDEKLNLETTLQESTAARQIMEREIENI-QTYQSTAEENFLQEIKNAKSEASIYKNSL 657
             ++D K +LE+  Q +     ++E++ + + ++ Q    +  L + + ++ +    +  +
Sbjct: 3233 ELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQV 3292

Query: 658  ---SEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVR 714
               SE  +  EM S +  E +   Q+   +    S+  +  E+ +  L   K L E + R
Sbjct: 3293 LLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKEL--QKQLEEKHSR 3350

Query: 715  SIENERDTLEFEMRHLQ 731
             +E   +T ++++  LQ
Sbjct: 3351 IVELLNETEKYKLDSLQ 3367


>gi|42794779 myosin 18A isoform b [Homo sapiens]
          Length = 2039

 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 87/424 (20%), Positives = 187/424 (44%), Gaps = 52/424 (12%)

Query: 354  EMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELES 413
            E KD +   F  K  S+ +E +  S   S  E  +AK++     L+  V+ Q++ ++ ++
Sbjct: 1503 EEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQA 1562

Query: 414  ENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEE----KSTIQSKLSKTEEYSKECLK 469
              + +  + K  +     + +  +T+ K++++  EE    + + Q KL + E   +E  +
Sbjct: 1563 GTIQMLEQAK--LRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYE 1620

Query: 470  EFKKIISKYNVLQGQNKTLE----------EKNIQLSLEKQQMMEA-------------- 505
            + +K++ +   L+G+  TL           EK ++  L++ + + A              
Sbjct: 1621 DKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAP 1680

Query: 506  ----LDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKE 561
                + QLK++  +++   A        M +E+E +   I  I   K  LE++  +L +E
Sbjct: 1681 SKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQRE 1740

Query: 562  KSSLGNELKESQLEIIQLKEKERLAKTE-QETLLQI------IETVKDEKLNLETTLQ-- 612
            K+ + N L+E Q ++ +L +K + A  +    L QI      +E    EK  L+  LQ  
Sbjct: 1741 KNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQAL 1800

Query: 613  --------ESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKEC 664
                    +S   + ++ R+   I+  ++  E    Q +K  +S AS  K ++ ++ +E 
Sbjct: 1801 QSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQ-VKRLESLASRLKENMEKLTEER 1859

Query: 665  EMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLE 724
            +         K  N+ L+ +L+   +E  +     +  +  K  LE  + S+E    +L+
Sbjct: 1860 DQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQ 1919

Query: 725  FEMR 728
             +++
Sbjct: 1920 ADLK 1923



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 90/427 (21%), Positives = 178/427 (41%), Gaps = 73/427 (17%)

Query: 374  NEKTSKVNSVTEQCVAKIQYLQNYLKESVQ------IQKKVMELESENLNLKSKMKPLIF 427
            +E+TS+  ++ +         Q++ K  +Q      +QK +     +N  +K      +F
Sbjct: 1185 DEQTSRNLTLFQAACRGYLARQHFKKRKIQDLAIRCVQKNI----KKNKGVKDWPWWKLF 1240

Query: 428  TTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKT 487
            TT   + +V+  E+Q++N  EE   ++SKL K E+   E      ++ S+ + L   ++ 
Sbjct: 1241 TTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISEL--TSEL 1298

Query: 488  LEEKNIQLSLEKQQMMEALDQLKS----KEHKTQSDMAIVNNENNRMSIEMEAMKTNILL 543
             +E+N   S  +    E  ++L++    KE +TQ D      +     +EME M+  ++ 
Sbjct: 1299 TDERNTGESASQLLDAETAERLRAEKEMKELQTQYDAL----KKQMEVMEMEVMEARLIR 1354

Query: 544  --------------------------------------IQDEKEMLEKKTHQLLKEKSSL 565
                                                   +D+ E+ ++   QL +    L
Sbjct: 1355 AAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDL 1414

Query: 566  GNELKESQLEIIQLKEK-ERLAKTEQETLLQII-ETVKDEKLNLETTLQESTAARQIMER 623
              + +ESQ  + QLK+K +RL    Q+T L +  + V++ +L  +    +S  ++   E 
Sbjct: 1415 QADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEA 1474

Query: 624  EIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKE 683
            + E +Q  +   E++ L       +EA   K  L E   +    ++ V+        L+ 
Sbjct: 1475 QREKLQREKLQREKDML------LAEAFSLKQQLEEKDMDIAGFTQKVVS-------LEA 1521

Query: 684  ELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICN 743
            EL+  S +  K E S++++ +    LE  V+  E E D     ++ L++  L L  ++  
Sbjct: 1522 ELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMER 1581

Query: 744  QHNDPSK 750
                 SK
Sbjct: 1582 MRQTHSK 1588


>gi|28416946 myosin 18A isoform a [Homo sapiens]
          Length = 2054

 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 87/424 (20%), Positives = 187/424 (44%), Gaps = 52/424 (12%)

Query: 354  EMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELES 413
            E KD +   F  K  S+ +E +  S   S  E  +AK++     L+  V+ Q++ ++ ++
Sbjct: 1503 EEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQA 1562

Query: 414  ENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEE----KSTIQSKLSKTEEYSKECLK 469
              + +  + K  +     + +  +T+ K++++  EE    + + Q KL + E   +E  +
Sbjct: 1563 GTIQMLEQAK--LRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYE 1620

Query: 470  EFKKIISKYNVLQGQNKTLE----------EKNIQLSLEKQQMMEA-------------- 505
            + +K++ +   L+G+  TL           EK ++  L++ + + A              
Sbjct: 1621 DKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAP 1680

Query: 506  ----LDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKE 561
                + QLK++  +++   A        M +E+E +   I  I   K  LE++  +L +E
Sbjct: 1681 SKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQRE 1740

Query: 562  KSSLGNELKESQLEIIQLKEKERLAKTE-QETLLQI------IETVKDEKLNLETTLQ-- 612
            K+ + N L+E Q ++ +L +K + A  +    L QI      +E    EK  L+  LQ  
Sbjct: 1741 KNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQAL 1800

Query: 613  --------ESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKEC 664
                    +S   + ++ R+   I+  ++  E    Q +K  +S AS  K ++ ++ +E 
Sbjct: 1801 QSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQ-VKRLESLASRLKENMEKLTEER 1859

Query: 665  EMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLE 724
            +         K  N+ L+ +L+   +E  +     +  +  K  LE  + S+E    +L+
Sbjct: 1860 DQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQ 1919

Query: 725  FEMR 728
             +++
Sbjct: 1920 ADLK 1923



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 90/427 (21%), Positives = 178/427 (41%), Gaps = 73/427 (17%)

Query: 374  NEKTSKVNSVTEQCVAKIQYLQNYLKESVQ------IQKKVMELESENLNLKSKMKPLIF 427
            +E+TS+  ++ +         Q++ K  +Q      +QK +     +N  +K      +F
Sbjct: 1185 DEQTSRNLTLFQAACRGYLARQHFKKRKIQDLAIRCVQKNI----KKNKGVKDWPWWKLF 1240

Query: 428  TTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKT 487
            TT   + +V+  E+Q++N  EE   ++SKL K E+   E      ++ S+ + L   ++ 
Sbjct: 1241 TTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISEL--TSEL 1298

Query: 488  LEEKNIQLSLEKQQMMEALDQLKS----KEHKTQSDMAIVNNENNRMSIEMEAMKTNILL 543
             +E+N   S  +    E  ++L++    KE +TQ D      +     +EME M+  ++ 
Sbjct: 1299 TDERNTGESASQLLDAETAERLRAEKEMKELQTQYDAL----KKQMEVMEMEVMEARLIR 1354

Query: 544  --------------------------------------IQDEKEMLEKKTHQLLKEKSSL 565
                                                   +D+ E+ ++   QL +    L
Sbjct: 1355 AAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDL 1414

Query: 566  GNELKESQLEIIQLKEK-ERLAKTEQETLLQII-ETVKDEKLNLETTLQESTAARQIMER 623
              + +ESQ  + QLK+K +RL    Q+T L +  + V++ +L  +    +S  ++   E 
Sbjct: 1415 QADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEA 1474

Query: 624  EIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKE 683
            + E +Q  +   E++ L       +EA   K  L E   +    ++ V+        L+ 
Sbjct: 1475 QREKLQREKLQREKDML------LAEAFSLKQQLEEKDMDIAGFTQKVVS-------LEA 1521

Query: 684  ELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICN 743
            EL+  S +  K E S++++ +    LE  V+  E E D     ++ L++  L L  ++  
Sbjct: 1522 ELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMER 1581

Query: 744  QHNDPSK 750
                 SK
Sbjct: 1582 MRQTHSK 1588


>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
          Length = 1417

 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 146/743 (19%), Positives = 297/743 (39%), Gaps = 126/743 (16%)

Query: 47   ENQIQPQSALKVLQQQLESFQALRMQTLQNVSMPTENQEENLSMEKSHHFEDSKTLHSVE 106
            E +I   S++     +LE     + + ++++      + E + +     FE +K +H  +
Sbjct: 707  EEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLA----FEKAKKIHLEQ 762

Query: 107  EKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIII--HPSENSDIL------- 157
             K     +  L   +    Q   E   T+      L  +II   H  E+ D L       
Sbjct: 763  HKEMEKQIERLEAQLEKKDQQFKEQEKTMSM----LQQDIICKQHHLESLDRLLTESKGE 818

Query: 158  -KNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQ 216
             K  N        A  N +S+ +T+ + +    +   K     +L+ +  + ++ +++L+
Sbjct: 819  MKKENMKKDEALKALQNQVSE-ETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLK 877

Query: 217  KSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRIS 276
            K  +    L  EL+               +    Q +   +++E +     ED ++K   
Sbjct: 878  KKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEK 937

Query: 277  ELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKF 336
            ++  L ++L   RE+ ++      RK ++  +S  H    + K  K I +TG        
Sbjct: 938  QVSKLEQELQKQRESSAEK----LRKMEEKCESAAHEA--DLKRQKVIELTG-------- 983

Query: 337  HSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKT--SKVNSVTEQCVAKIQYL 394
                 R     +DQ K E+   E++   +K+     EN+    S+++ + +Q   +++  
Sbjct: 984  ---TARQVKIEMDQYKEELSKMEKEIMHLKRDG---ENKAMHLSQLDMILDQTKTELEKK 1037

Query: 395  QNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQ 454
             N +KE  ++Q      E+E              T++L QK E  E +L+N   E   ++
Sbjct: 1038 TNAVKELEKLQHST---ETE-------------LTEAL-QKREVLETELQNAHGE---LK 1077

Query: 455  SKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKS--- 511
            S L + +E      K    +  KY  ++     L E  +++  +KQ+++E    LK    
Sbjct: 1078 STLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNW 1137

Query: 512  ----------------KEHKTQSDMAIVNNENNRMSIEMEAMKTNILL------IQDEKE 549
                            +EH+ + +  I+  E      E+E  + N  +      +Q+ KE
Sbjct: 1138 ELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKE 1197

Query: 550  MLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQE----------TLLQIIET 599
             L +K   +L+ +  +    KE +    ++KE E + K +++           L Q +  
Sbjct: 1198 QLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRL 1257

Query: 600  VKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLS- 658
             +++  N  T L E+   +   +REIE + +         L+++K    E   + N L+ 
Sbjct: 1258 TREQVQNSHTELAEARHQQVQAQREIERLSSE--------LEDMKQLSKEKDAHGNHLAE 1309

Query: 659  EIG----KECEMLSKMVMETK---TDNQILKE----ELKKHSQENIKF-------ENSIS 700
            E+G    +E  + ++M  E K    + + LKE    E+  H + + K+       ++S+ 
Sbjct: 1310 ELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQ 1369

Query: 701  RLTEDKILLENYVRSIENERDTL 723
            +L E    LE     +E  +DT+
Sbjct: 1370 QLNEQ---LEKAKLELEEAQDTV 1389



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 84/408 (20%), Positives = 173/408 (42%), Gaps = 61/408 (14%)

Query: 375 EKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQ 434
           E  +K+    +  + K Q LQ   +E ++++  ++E   +    + +    ++  + L +
Sbjct: 309 EAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSK 368

Query: 435 KVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQ 494
             + Y+K++   +E+   +Q++    E     C KE              NK L+E+   
Sbjct: 369 AFQQYKKKVAEKLEK---VQAEEEILERNLTNCEKE--------------NKRLQERCGL 411

Query: 495 LSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKK 554
              E + + E L QLK + +  +  + I+  +N+ +  ++   + +IL ++ E   LE K
Sbjct: 412 YKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESE---LENK 468

Query: 555 THQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQES 614
             ++L++K SL NE +E  L++    + ERL   +QE     IE+ + E  +LE  + + 
Sbjct: 469 -DEILRDKFSLMNENRE--LKVRVAAQNERLDLCQQE-----IESSRVELRSLEKIISQL 520

Query: 615 TAARQIMEREIENIQTYQSTAEEN-----------------------FLQEIKNAKSEAS 651
              R++   +   +  YQ ++  N                        ++E +  K  A+
Sbjct: 521 PLKRELFGFK-SYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHAN 579

Query: 652 IYKNSLSEI------GKECEMLSKMVME-TKTDNQILKEELKKHSQE--NIKFENSISRL 702
           +  N LS+        +E   LS +  E  K     + E +K  +Q   N ++E    RL
Sbjct: 580 LTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRL 639

Query: 703 TEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSK 750
                 L   +  IE E   L+  M H   ++  + +++  + ++ SK
Sbjct: 640 VTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSK 687



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 96/461 (20%), Positives = 197/461 (42%), Gaps = 47/461 (10%)

Query: 346  SFLDQTKHEMK---DKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESV 402
            S  DQ +H M    +KERQ  +        E  +T  +    E    K+  + +   +  
Sbjct: 619  SVKDQNQHTMNKQYEKERQRLVTG-----IEELRTKLIQIEAENSDLKVN-MAHRTSQFQ 672

Query: 403  QIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEE 462
             IQ++++E  S +  L+S+M      T+   Q + T EKQL+  +   S+I +K ++ E+
Sbjct: 673  LIQEELLEKASNSSKLESEM------TKKCSQLL-TLEKQLEEKIVAYSSIAAKNAELEQ 725

Query: 463  YSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEAL-----DQLKSKEHKTQ 517
               E  ++ + + +  N    +     EK  ++ LE+ + ME        QL+ K+ + +
Sbjct: 726  ELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFK 785

Query: 518  SDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEII 577
                 ++     +  +   +++   L+ + K  ++K+  +  +   +L N++ E  +++ 
Sbjct: 786  EQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVR 845

Query: 578  QLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIE-NIQTYQSTAE 636
            QL     + K E   L+  +  ++  K   E  L++ +     +++E++    + Q T+E
Sbjct: 846  QLDSALEICKEE---LVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSE 902

Query: 637  ENF-----LQEIKNAKSEASIYKNSLSEIGKECE-MLSKMVMETKTDNQILKEELKKHSQ 690
            +N      LQ+ +    + +I    L +   + E  +SK+  E +   +   E+L+K  +
Sbjct: 903  QNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEE 962

Query: 691  ENIKFENSISRLTEDKILLENYVRSIENERD-------TLEFEMRHLQRE------YLSL 737
            +     +      +  I L    R ++ E D        +E E+ HL+R+      +LS 
Sbjct: 963  KCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQ 1022

Query: 738  SDKICNQHND--PSKTTYISRREKFHFDNYTHEDTSSPQSR 776
             D I +Q       KT  +   EK      T E T + Q R
Sbjct: 1023 LDMILDQTKTELEKKTNAVKELEKLQHSTET-ELTEALQKR 1062



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 111/536 (20%), Positives = 222/536 (41%), Gaps = 92/536 (17%)

Query: 273 KRISELEALVKKLLPFRETVSKFHVHF----------CRKCKKLSKSEMHRGKKNEKNNK 322
           K IS+L  L ++L  F+  +SK+ +            C +  KL  SE+           
Sbjct: 515 KIISQLP-LKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELR---------- 563

Query: 323 EIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQ-----GSIISENEKT 377
            I +  K     K H+ +    LS    T ++ ++  +   L  +     G  ++E+ K 
Sbjct: 564 -IKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKD 622

Query: 378 SKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVE 437
              +++ +Q   + Q L   ++E   ++ K++++E+EN +LK  M     T+Q  + + E
Sbjct: 623 QNQHTMNKQYEKERQRLVTGIEE---LRTKLIQIEAENSDLKVNMAHR--TSQFQLIQEE 677

Query: 438 TYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSL 497
             EK         S ++S+++K                 K + L    K LEEK +  S 
Sbjct: 678 LLEK-----ASNSSKLESEMTK-----------------KCSQLLTLEKQLEEKIVAYSS 715

Query: 498 EKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEM------- 550
              +  E   +L  K  K +S    +N E+ ++ +  E  K   + ++  KEM       
Sbjct: 716 IAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFE--KAKKIHLEQHKEMEKQIERL 773

Query: 551 ---LEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLN- 606
              LEKK  Q  +++ ++    ++   +   L+  +RL  TE +  ++     KDE L  
Sbjct: 774 EAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLL-TESKGEMKKENMKKDEALKA 832

Query: 607 LETTLQEST-------AARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSE 659
           L+  + E T       +A +I + E+          +E F +++K    E          
Sbjct: 833 LQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYC------- 885

Query: 660 IGKECEMLSKMVMETKTDNQILKEELKKHSQ-------ENIKFENSISRLTEDKILLENY 712
           + KE ++ +  + ET   N IL+  L++  Q        N + E++ ++L +    LE  
Sbjct: 886 LQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLE-- 943

Query: 713 VRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRREKFHFDNYTHE 768
            + ++ +R++   ++R ++ +  S + +   +     + T  +R+ K   D Y  E
Sbjct: 944 -QELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEE 998



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 81/424 (19%), Positives = 172/424 (40%), Gaps = 86/424 (20%)

Query: 413 SENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFK 472
           S+  N  ++ + L+    SL  +++  E  L++L EE S++    S+  +Y+    +  K
Sbjct: 124 SDYYNKDNEEESLLANVASLRHELKITEWSLQSLGEELSSVSP--SENSDYAPNPSRSEK 181

Query: 473 KIISKYNVLQGQ-NKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMS 531
            I+       G  N +  E   ++S        + D  K    K  S  A V+ E     
Sbjct: 182 LILDVQPSHPGLLNYSPYENVCKIS------GSSTDFQKKPRDKMFSSSAPVDQE----- 230

Query: 532 IEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLA----- 586
             +++++  +  ++ +   L  + H L+ +  S+  EL +S+ ++  L+  ++ A     
Sbjct: 231 --IKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPI 288

Query: 587 ------------------------KTEQETLL-----QIIETVKDEKLNLETTLQESTAA 617
                                   K EQ   +     Q ++  K+E + L+  L E T  
Sbjct: 289 LEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQ 348

Query: 618 RQIMERE-------IENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKM 670
            +  ER+        E +       ++   ++++  ++E  I + +L+   KE + L + 
Sbjct: 349 GKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQER 408

Query: 671 VMETKTDNQILKEELKKHSQEN-----------IKFENSISRLTEDKILLENYVRSIEN- 718
               K++ +ILKE+L++  +EN           +K    +++LTE +  +      +EN 
Sbjct: 409 CGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENK 468

Query: 719 -----ERDTLEFEMRHLQREYLSLSDK--ICNQHNDPSKTTYIS----------RREKFH 761
                ++ +L  E R L+    + +++  +C Q  + S+    S          +RE F 
Sbjct: 469 DEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFG 528

Query: 762 FDNY 765
           F +Y
Sbjct: 529 FKSY 532


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.125    0.330 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,923,609
Number of Sequences: 37866
Number of extensions: 1196386
Number of successful extensions: 11944
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 325
Number of HSP's successfully gapped in prelim test: 1017
Number of HSP's that attempted gapping in prelim test: 5653
Number of HSP's gapped (non-prelim): 3875
length of query: 796
length of database: 18,247,518
effective HSP length: 110
effective length of query: 686
effective length of database: 14,082,258
effective search space: 9660428988
effective search space used: 9660428988
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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