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Search of human proteins with 224451131
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|224451131 eyes shut homolog isoform 2 [Homo sapiens]
(619 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|224451131 eyes shut homolog isoform 2 [Homo sapiens] 1350 0.0
gi|224451128 eyes shut homolog isoform 1 [Homo sapiens] 1290 0.0
gi|38093661 eyes shut homolog isoform 3 [Homo sapiens] 1290 0.0
gi|116235485 delta-notch-like EGF repeat-containing transmembran... 181 1e-45
gi|148833508 notch1 preproprotein [Homo sapiens] 162 1e-39
gi|4557679 jagged 1 precursor [Homo sapiens] 157 2e-38
gi|110735443 delta-like 1 [Homo sapiens] 155 1e-37
gi|24041035 notch 2 preproprotein [Homo sapiens] 154 3e-37
gi|9506545 delta-like 4 protein precursor [Homo sapiens] 137 3e-32
gi|21704279 jagged 2 isoform b precursor [Homo sapiens] 137 3e-32
gi|148886654 polydom [Homo sapiens] 134 2e-31
gi|55770876 notch4 preproprotein [Homo sapiens] 133 4e-31
gi|134244285 Notch homolog 3 [Homo sapiens] 130 4e-30
gi|41327708 crumbs homolog 1 precursor [Homo sapiens] 128 1e-29
gi|21704277 jagged 2 isoform a precursor [Homo sapiens] 127 2e-29
gi|122937283 6720455I24Rik homolog [Homo sapiens] 121 2e-27
gi|112420992 crumbs homolog 2 [Homo sapiens] 112 1e-24
gi|4759146 slit homolog 2 [Homo sapiens] 108 2e-23
gi|188528675 slit homolog 1 [Homo sapiens] 107 2e-23
gi|74136023 delta-like 1 homolog [Homo sapiens] 105 2e-22
gi|11321571 slit homolog 3 [Homo sapiens] 101 2e-21
gi|8393264 delta-like 3 protein isoform 1 precursor [Homo sapiens] 98 3e-20
gi|45243561 delta-like 3 protein isoform 2 precursor [Homo sapiens] 98 3e-20
gi|46397353 Notch homolog 2 N-terminal like protein [Homo sapiens] 98 3e-20
gi|24430141 fibrillin 1 precursor [Homo sapiens] 97 3e-20
gi|45593147 EGF-like-domain, multiple 9 [Homo sapiens] 94 3e-19
gi|45545431 EGF-like-domain, multiple 9 [Homo sapiens] 94 3e-19
gi|46249414 latent transforming growth factor beta binding prote... 91 4e-18
gi|46249412 latent transforming growth factor beta binding prote... 91 4e-18
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 87 3e-17
>gi|224451131 eyes shut homolog isoform 2 [Homo sapiens]
Length = 619
Score = 1350 bits (3494), Expect = 0.0
Identities = 619/619 (100%), Positives = 619/619 (100%)
Query: 1 MTDKSIVILSLMVFHSSFINGKTCRRQLVEEWHPQPSSYVVNWTLTENICLDFYRDCWFL 60
MTDKSIVILSLMVFHSSFINGKTCRRQLVEEWHPQPSSYVVNWTLTENICLDFYRDCWFL
Sbjct: 1 MTDKSIVILSLMVFHSSFINGKTCRRQLVEEWHPQPSSYVVNWTLTENICLDFYRDCWFL 60
Query: 61 GVNTKIDTSGNQAVPQICPLQIQLGDILVISSEPSLQFPEINLMNVSETSFVGCVQNTTT 120
GVNTKIDTSGNQAVPQICPLQIQLGDILVISSEPSLQFPEINLMNVSETSFVGCVQNTTT
Sbjct: 61 GVNTKIDTSGNQAVPQICPLQIQLGDILVISSEPSLQFPEINLMNVSETSFVGCVQNTTT 120
Query: 121 EDQLLFGCRLKGMHTVNSKWLSVGTHYFITVMASGPSPCPLGLRLNVTVKQQFCQESLSS 180
EDQLLFGCRLKGMHTVNSKWLSVGTHYFITVMASGPSPCPLGLRLNVTVKQQFCQESLSS
Sbjct: 121 EDQLLFGCRLKGMHTVNSKWLSVGTHYFITVMASGPSPCPLGLRLNVTVKQQFCQESLSS 180
Query: 181 EFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAY 240
EFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAY
Sbjct: 181 EFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAY 240
Query: 241 ECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVS 300
ECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVS
Sbjct: 241 ECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVS 300
Query: 301 LLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSP 360
LLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSP
Sbjct: 301 LLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSP 360
Query: 361 IFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCL 420
IFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCL
Sbjct: 361 IFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCL 420
Query: 421 NEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYV 480
NEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYV
Sbjct: 421 NEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYV 480
Query: 481 WQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCS 540
WQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCS
Sbjct: 481 WQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCS 540
Query: 541 CLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRRILNTVIPHQI 600
CLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRRILNTVIPHQI
Sbjct: 541 CLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRRILNTVIPHQI 600
Query: 601 QQHIERFIQHDQVGFIVRI 619
QQHIERFIQHDQVGFIVRI
Sbjct: 601 QQHIERFIQHDQVGFIVRI 619
>gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]
Length = 3144
Score = 1290 bits (3339), Expect = 0.0
Identities = 589/589 (100%), Positives = 589/589 (100%)
Query: 1 MTDKSIVILSLMVFHSSFINGKTCRRQLVEEWHPQPSSYVVNWTLTENICLDFYRDCWFL 60
MTDKSIVILSLMVFHSSFINGKTCRRQLVEEWHPQPSSYVVNWTLTENICLDFYRDCWFL
Sbjct: 1 MTDKSIVILSLMVFHSSFINGKTCRRQLVEEWHPQPSSYVVNWTLTENICLDFYRDCWFL 60
Query: 61 GVNTKIDTSGNQAVPQICPLQIQLGDILVISSEPSLQFPEINLMNVSETSFVGCVQNTTT 120
GVNTKIDTSGNQAVPQICPLQIQLGDILVISSEPSLQFPEINLMNVSETSFVGCVQNTTT
Sbjct: 61 GVNTKIDTSGNQAVPQICPLQIQLGDILVISSEPSLQFPEINLMNVSETSFVGCVQNTTT 120
Query: 121 EDQLLFGCRLKGMHTVNSKWLSVGTHYFITVMASGPSPCPLGLRLNVTVKQQFCQESLSS 180
EDQLLFGCRLKGMHTVNSKWLSVGTHYFITVMASGPSPCPLGLRLNVTVKQQFCQESLSS
Sbjct: 121 EDQLLFGCRLKGMHTVNSKWLSVGTHYFITVMASGPSPCPLGLRLNVTVKQQFCQESLSS 180
Query: 181 EFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAY 240
EFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAY
Sbjct: 181 EFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAY 240
Query: 241 ECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVS 300
ECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVS
Sbjct: 241 ECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVS 300
Query: 301 LLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSP 360
LLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSP
Sbjct: 301 LLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSP 360
Query: 361 IFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCL 420
IFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCL
Sbjct: 361 IFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCL 420
Query: 421 NEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYV 480
NEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYV
Sbjct: 421 NEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYV 480
Query: 481 WQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCS 540
WQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCS
Sbjct: 481 WQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCS 540
Query: 541 CLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPR 589
CLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPR
Sbjct: 541 CLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPR 589
Score = 145 bits (365), Expect = 1e-34
Identities = 116/465 (24%), Positives = 170/465 (36%), Gaps = 112/465 (24%)
Query: 197 TYSCHCQPPFSGKYC-QELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSE 255
+Y C C + G +C QE + C PCKNN +C + ++ Y C C +TG+NCSE
Sbjct: 754 SYQCVCLSDWEGNFCEQESNECKMNPCKNNSTCTDLYKS-----YRCECTSGWTGQNCSE 808
Query: 256 IIGQCQPHVCFHGN--------------CSNITSNSFI---------------------- 279
I +C C +G C + + F
Sbjct: 809 EINECDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLA 868
Query: 280 -------CECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETD 332
C C E+F G CE+ K C+ L G C + + + C G S E +
Sbjct: 869 LVDANQHCICREEFEGKNCEIDVKDCLFLSCQDYGDCEDMVNNFRCICRPGFSGSLCEIE 928
Query: 333 VSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDY 392
++E S PC+N C+ ++N C C P + C+ C+ P + C Y
Sbjct: 929 INECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELDVNKCKISPCLDEENCVYRTDGY 988
Query: 393 PCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPG------------C 440
C C G+T NCE +D C LS CL++ C + I + C G C
Sbjct: 989 NCLCAPGYTGINCEINLDEC--LSEPCLHDGVCIDGINHYTCDCKSGFFGTHCETNANDC 1046
Query: 441 TKNPCWFLKNVYLIHQHLCYCGV-------------------TFHGICQDKGPAQFEYVW 481
NPC + LI+++ C C G CQ K F +
Sbjct: 1047 LSNPCLHGRCTELINEYPCSCDADGTSTQCKIKINDCTSIPCMNEGFCQ-KSAHGFTCIC 1105
Query: 482 QLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCSC 541
G+ G+ C+ ID NC E PE N+ IC NG C
Sbjct: 1106 PRGYTGA---YCEKSID-------NCAE-------PELNS-----------VICLNGGIC 1137
Query: 542 LSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEIN 586
+ + + C ++G N + + C H A C+D IN
Sbjct: 1138 V-DGPGHTFDCRCLPGFSGQFCEININECSSSPCLHGADCEDHIN 1181
Score = 140 bits (352), Expect = 5e-33
Identities = 85/297 (28%), Positives = 129/297 (43%), Gaps = 36/297 (12%)
Query: 202 CQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQA---------YECVCHPPFTGK 251
C P F G C+ ++D C+ PCKN +CI++ N+ Q + C+C+P + G
Sbjct: 669 CVPGFKGTQCEIDIDECASHPCKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGI 728
Query: 252 NCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPN 311
C + I C + C H + S+ C C + G FCE + C C +
Sbjct: 729 RCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFCEQESNECKMNPCKNNSTCTD 788
Query: 312 SSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIK--ISNDVMCICSPIFTDLLCKS 369
+Y EC G + QN +++E PC NG C + I +C+C P++T C
Sbjct: 789 LYKSYRCECTSGWTGQNCSEEINECDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQ 848
Query: 370 IQTSCESF--PLRNNATC-KKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCF 426
C+ P RNN+TC + + C C F KNCE + C LS C + C
Sbjct: 849 RYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLFLS--CQDYGDCE 906
Query: 427 NIIGRFKYVCIPG------------CTKNPCWFLKN----VYLIHQHLCYCGVTFHG 467
+++ F+ +C PG C+ PC KN V L ++ C C +HG
Sbjct: 907 DMVNNFRCICRPGFSGSLCEIEINECSSEPC---KNNGTCVDLTNRFFCNCEPEYHG 960
Score = 116 bits (290), Expect = 7e-26
Identities = 69/249 (27%), Positives = 108/249 (43%), Gaps = 17/249 (6%)
Query: 198 YSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEI 256
Y+C C P ++G C+ LD C +PC ++G CI+ + Y C C F G +C
Sbjct: 988 YNCLCAPGYTGINCEINLDECLSEPCLHDGVCIDGINH-----YTCDCKSGFFGTHCETN 1042
Query: 257 IGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAY 316
C + C HG C+ + N + C CD + C++ C S+ G C S+ +
Sbjct: 1043 ANDCLSNPCLHGRCTELI-NEYPCSCDADGTSTQCKIKINDCTSIPCMNEGFCQKSAHGF 1101
Query: 317 TYECPKGSSSQNGETDVS-----EFSLVPCQNGTDCIKISNDVM-CICSPIFTDLLCKSI 370
T CP+G + E + E + V C NG C+ C C P F+ C+
Sbjct: 1102 TCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFSGQFCEIN 1161
Query: 371 QTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIG 430
C S P + A C+ Y C C G++ +CE ++ + +C++E N G
Sbjct: 1162 INECSSSPCLHGADCEDHINGYVCKCQPGWSGHHCENELE---CIPNSCVHELCMENEPG 1218
Query: 431 RFKYVCIPG 439
+C PG
Sbjct: 1219 S-TCLCTPG 1226
Score = 97.4 bits (241), Expect = 3e-20
Identities = 97/439 (22%), Positives = 165/439 (37%), Gaps = 50/439 (11%)
Query: 179 SSEFCSGHGKCLSEAWSKTYSCHCQPPFSGK-YCQELDACSFKPCKNNGSCINKRENWDE 237
+ E C+ CLSE S+ Y C ++G Y + C++ C ++
Sbjct: 531 TKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINR--- 587
Query: 238 QAYECVCHPPFTGKNCSEIIGQCQPH--VCFHGNCSNITSNSFICECD--EQFSGPFCEV 293
C C + G+ C + C + + HG C ++ N C C +++ CE+
Sbjct: 588 --PRCSCSLSYIGRLCVVNVDYCLGNHSISVHGLCLALSHN---CNCSGLQRYERNICEI 642
Query: 294 SAKPCVSLLFWKRGICPNSSSAYTY-ECPKGSSSQNGETDVSEFSLVPCQNGTDCI---- 348
+ C S K G Y + +C G E D+ E + PC+NG CI
Sbjct: 643 DTEDCKSASC-KNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDECASHPCKNGATCIDQPG 701
Query: 349 ----------KISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCIS 398
K+ + C+C+P + + C+ C +N+TCK Y C C+S
Sbjct: 702 NYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLS 761
Query: 399 GFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHL 458
+ CE+ + CK+ C N C ++ ++ C G T C + +
Sbjct: 762 DWEGNFCEQESNECKMNP--CKNNSTCTDLYKSYRCECTSGWTGQNC--SEEINECDSDP 817
Query: 459 CYCGVTFHGICQDKG-PAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDP 517
C G G+C + P QF + + G + + D L C ++T +
Sbjct: 818 CMNG----GLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCD---LLHNPCRNNSTCLALV 870
Query: 518 EDNNSS-CWFPHEGTK-EICANGCSCLSEEDSQE-------YRYLCFLRWAGNMYLENTT 568
+ N C EG EI C LS +D + +R +C ++G++
Sbjct: 871 DANQHCICREEFEGKNCEIDVKDCLFLSCQDYGDCEDMVNNFRCICRPGFSGSLCEIEIN 930
Query: 569 DDQENECQHEAVCKDEINR 587
+ C++ C D NR
Sbjct: 931 ECSSEPCKNNGTCVDLTNR 949
Score = 71.6 bits (174), Expect = 2e-12
Identities = 49/186 (26%), Positives = 79/186 (42%), Gaps = 20/186 (10%)
Query: 186 HGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQAYECVC 244
HG+C Y C C + C+ +++ C+ PC N G C + C+C
Sbjct: 1053 HGRCTELI--NEYPCSCDADGTSTQCKIKINDCTSIPCMNEGFCQKSAHG-----FTCIC 1105
Query: 245 HPPFTGKNCSEIIGQC-QPH----VCFHGN-CSNITSNSFICECDEQFSGPFCEVSAKPC 298
+TG C + I C +P +C +G C + ++F C C FSG FCE++ C
Sbjct: 1106 PRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFSGQFCEININEC 1165
Query: 299 VSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVP--CQNGTDCIKISNDVMC 356
S C + + Y +C G S + E +E +P C + C++ C
Sbjct: 1166 SSSPCLHGADCEDHINGYVCKCQPGWSGHHCE---NELECIPNSCVHEL-CMENEPGSTC 1221
Query: 357 ICSPIF 362
+C+P F
Sbjct: 1222 LCTPGF 1227
Score = 62.0 bits (149), Expect = 2e-09
Identities = 33/116 (28%), Positives = 53/116 (45%), Gaps = 12/116 (10%)
Query: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQE-LDACSFKP-----CKNNGSCINKRENWD 236
C G C A ++C C ++G YC++ +D C+ C N G C++ +
Sbjct: 1088 CMNEGFCQKSAHG--FTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGH-- 1143
Query: 237 EQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCE 292
++C C P F+G+ C I +C C HG N ++C+C +SG CE
Sbjct: 1144 --TFDCRCLPGFSGQFCEININECSSSPCLHGADCEDHINGYVCKCQPGWSGHHCE 1197
Score = 44.7 bits (104), Expect = 3e-04
Identities = 24/76 (31%), Positives = 35/76 (46%), Gaps = 8/76 (10%)
Query: 217 CSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHG-NCSNITS 275
C+ C+NNG+CI+ EN C C ++GK C C+ + C +G C +
Sbjct: 2339 CAHHLCRNNGTCISDNEN-----LFCECPRLYSGKLCQ--FASCENNPCGNGATCVPKSG 2391
Query: 276 NSFICECDEQFSGPFC 291
+C C SGP C
Sbjct: 2392 TDIVCLCPYGRSGPLC 2407
Score = 43.9 bits (102), Expect = 4e-04
Identities = 22/78 (28%), Positives = 36/78 (46%), Gaps = 7/78 (8%)
Query: 216 ACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGN-CSNIT 274
AC + C+N G C + + C C P + G C++ + C ++C H + C
Sbjct: 2878 ACGYNTCRNGGEC-----TVNGTTFSCRCLPDWAGNTCNQSV-SCLNNLCLHQSLCIPDQ 2931
Query: 275 SNSFICECDEQFSGPFCE 292
S S+ C C + G +CE
Sbjct: 2932 SFSYSCLCTLGWVGRYCE 2949
Score = 43.5 bits (101), Expect = 6e-04
Identities = 24/80 (30%), Positives = 37/80 (46%), Gaps = 7/80 (8%)
Query: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYEC 242
C +G C+S+ ++ C C +SGK CQ +C PC N +C+ K C
Sbjct: 2344 CRNNGTCISD--NENLFCECPRLYSGKLCQ-FASCENNPCGNGATCVPK----SGTDIVC 2396
Query: 243 VCHPPFTGKNCSEIIGQCQP 262
+C +G C++ I QP
Sbjct: 2397 LCPYGRSGPLCTDAINITQP 2416
Score = 43.5 bits (101), Expect = 6e-04
Identities = 25/86 (29%), Positives = 35/86 (40%), Gaps = 5/86 (5%)
Query: 329 GETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCE-----SFPLRNNA 383
G+ S SL+ C NG CI+ V C C+ + C ++C+ A
Sbjct: 2607 GQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGA 2666
Query: 384 TCKKCEKDYPCSCISGFTEKNCEKAI 409
TC Y C C G T CE+A+
Sbjct: 2667 TCISLPHGYTCFCPLGTTGIYCEQAL 2692
Score = 43.1 bits (100), Expect = 8e-04
Identities = 24/71 (33%), Positives = 35/71 (49%), Gaps = 3/71 (4%)
Query: 341 CQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATC-KKCEKDYPCSCISG 399
C+N CI + ++ C C +++ LC+ SCE+ P N ATC K D C C G
Sbjct: 2344 CRNNGTCISDNENLFCECPRLYSGKLCQF--ASCENNPCGNGATCVPKSGTDIVCLCPYG 2401
Query: 400 FTEKNCEKAID 410
+ C AI+
Sbjct: 2402 RSGPLCTDAIN 2412
Score = 39.7 bits (91), Expect = 0.008
Identities = 25/98 (25%), Positives = 34/98 (34%), Gaps = 22/98 (22%)
Query: 200 CHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQ 259
CH P CS C N G+CI + C C + G C+E +
Sbjct: 2609 CHASP------------CSLMKCGNGGTCIESGTS-----VYCNCTTGWKGSFCTETVST 2651
Query: 260 CQ-----PHVCFHGNCSNITSNSFICECDEQFSGPFCE 292
C PH C G + + C C +G +CE
Sbjct: 2652 CDPEHDPPHHCSRGATCISLPHGYTCFCPLGTTGIYCE 2689
Score = 38.5 bits (88), Expect = 0.019
Identities = 19/71 (26%), Positives = 31/71 (43%), Gaps = 6/71 (8%)
Query: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYEC 242
C G+C T+SC C P ++G C + +C C + CI + +Y C
Sbjct: 2884 CRNGGECTVNG--TTFSCRCLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQ----SFSYSC 2937
Query: 243 VCHPPFTGKNC 253
+C + G+ C
Sbjct: 2938 LCTLGWVGRYC 2948
Score = 35.0 bits (79), Expect = 0.20
Identities = 30/125 (24%), Positives = 45/125 (36%), Gaps = 49/125 (39%)
Query: 250 GKNCSEI-IGQCQPHVCFH-GNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRG 307
GKN + C H+C + G C + N F CEC +SG C+ ++
Sbjct: 2328 GKNIENCHVPWCAHHLCRNNGTCISDNENLF-CECPRLYSGKLCQFAS------------ 2374
Query: 308 ICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCI-KISNDVMCIC-----SPI 361
C N+ PC NG C+ K D++C+C P+
Sbjct: 2375 -CENN---------------------------PCGNGATCVPKSGTDIVCLCPYGRSGPL 2406
Query: 362 FTDLL 366
TD +
Sbjct: 2407 CTDAI 2411
Score = 33.5 bits (75), Expect = 0.60
Identities = 21/101 (20%), Positives = 33/101 (32%)
Query: 306 RGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDL 365
R + N+ E S G+ D + C+NG +C C C P +
Sbjct: 2849 RQVIINNQELQLTEFGAKGGSNVGDCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGN 2908
Query: 366 LCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCE 406
C + + L + Y C C G+ + CE
Sbjct: 2909 TCNQSVSCLNNLCLHQSLCIPDQSFSYSCLCTLGWVGRYCE 2949
Score = 30.4 bits (67), Expect = 5.0
Identities = 17/41 (41%), Positives = 21/41 (51%), Gaps = 5/41 (12%)
Query: 260 CQPHVCFHGN-CSNITSNS----FICECDEQFSGPFCEVSA 295
CQ VC +G C I +S F C+C F+G FCE A
Sbjct: 2103 CQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKDA 2143
Score = 30.0 bits (66), Expect = 6.6
Identities = 22/84 (26%), Positives = 29/84 (34%), Gaps = 10/84 (11%)
Query: 252 NCSEIIGQCQPHVCFHGNCSN-----ITSNSFICECDEQFSGPFCEVSAKPC----VSLL 302
N +GQC C C N + S C C + G FC + C
Sbjct: 2601 NAGRSVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPH 2660
Query: 303 FWKRG-ICPNSSSAYTYECPKGSS 325
RG C + YT CP G++
Sbjct: 2661 HCSRGATCISLPHGYTCFCPLGTT 2684
>gi|38093661 eyes shut homolog isoform 3 [Homo sapiens]
Length = 594
Score = 1290 bits (3339), Expect = 0.0
Identities = 589/589 (100%), Positives = 589/589 (100%)
Query: 1 MTDKSIVILSLMVFHSSFINGKTCRRQLVEEWHPQPSSYVVNWTLTENICLDFYRDCWFL 60
MTDKSIVILSLMVFHSSFINGKTCRRQLVEEWHPQPSSYVVNWTLTENICLDFYRDCWFL
Sbjct: 1 MTDKSIVILSLMVFHSSFINGKTCRRQLVEEWHPQPSSYVVNWTLTENICLDFYRDCWFL 60
Query: 61 GVNTKIDTSGNQAVPQICPLQIQLGDILVISSEPSLQFPEINLMNVSETSFVGCVQNTTT 120
GVNTKIDTSGNQAVPQICPLQIQLGDILVISSEPSLQFPEINLMNVSETSFVGCVQNTTT
Sbjct: 61 GVNTKIDTSGNQAVPQICPLQIQLGDILVISSEPSLQFPEINLMNVSETSFVGCVQNTTT 120
Query: 121 EDQLLFGCRLKGMHTVNSKWLSVGTHYFITVMASGPSPCPLGLRLNVTVKQQFCQESLSS 180
EDQLLFGCRLKGMHTVNSKWLSVGTHYFITVMASGPSPCPLGLRLNVTVKQQFCQESLSS
Sbjct: 121 EDQLLFGCRLKGMHTVNSKWLSVGTHYFITVMASGPSPCPLGLRLNVTVKQQFCQESLSS 180
Query: 181 EFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAY 240
EFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAY
Sbjct: 181 EFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAY 240
Query: 241 ECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVS 300
ECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVS
Sbjct: 241 ECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVS 300
Query: 301 LLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSP 360
LLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSP
Sbjct: 301 LLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSP 360
Query: 361 IFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCL 420
IFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCL
Sbjct: 361 IFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCL 420
Query: 421 NEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYV 480
NEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYV
Sbjct: 421 NEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYV 480
Query: 481 WQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCS 540
WQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCS
Sbjct: 481 WQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCS 540
Query: 541 CLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPR 589
CLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPR
Sbjct: 541 CLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPR 589
>gi|116235485 delta-notch-like EGF repeat-containing transmembrane
[Homo sapiens]
Length = 737
Score = 181 bits (460), Expect = 1e-45
Identities = 105/348 (30%), Positives = 160/348 (45%), Gaps = 9/348 (2%)
Query: 101 INLMNVSETSFVGCVQNTTTEDQLLFGCRLKGMHTVNSKWLSVGTHYFITVMASGPSPCP 160
I L V+ T F C + + + + + G + + L++G ++FI + +
Sbjct: 237 ILLWKVTATGFQQC---SLIDGRSVTPLQASGGLVLLEEMLALGNNHFIGFVNDSVTKSI 293
Query: 161 LGLRLNVTVKQQFCQ--ESLSSEF-CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDAC 217
+ LRL + VK C ES +++ CSG GKC ++ T+SC C+ + G +C+E DAC
Sbjct: 294 VALRLTLVVKVSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDAC 353
Query: 218 SFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNS 277
KPC+NN SCI+ E D + CVC P +TG+ C I C C +G + +
Sbjct: 354 QRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSG 413
Query: 278 FICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFS 337
F C+C E + G CE PC S G C +T C G + + +
Sbjct: 414 FTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCA 473
Query: 338 LVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCI 397
L PC +GT C + C+C P + L C+ C S P N ATC+ Y C C+
Sbjct: 474 LSPCAHGT-CRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCL 532
Query: 398 SGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPC 445
+ + +CE D C +++CLN C + +C PG T C
Sbjct: 533 AEYKGTHCELYKDPC--ANVSCLNGATCDSDGLNGTCICAPGFTGEEC 578
Score = 119 bits (297), Expect = 1e-26
Identities = 66/225 (29%), Positives = 95/225 (42%), Gaps = 9/225 (4%)
Query: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQE-LDACSFKPCKNNGSCINKRENWDEQAYE 241
C C+S ++C C + G C+E +D C+ PC+NNG+C D +
Sbjct: 401 CRNGATCISSL--SGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYV-----DGVHFT 453
Query: 242 CVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSL 301
C C P FTG C+++I C C HG C ++ S+ C CD + G +CE C+S
Sbjct: 454 CNCSPGFTGPTCAQLIDFCALSPCAHGTCRSV-GTSYKCLCDPGYHGLYCEEEYNECLSA 512
Query: 302 LFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPI 361
C + + Y C + E + V C NG C + CIC+P
Sbjct: 513 PCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPG 572
Query: 362 FTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCE 406
FT C C+S P + +C Y C C G+ NCE
Sbjct: 573 FTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCE 617
Score = 90.1 bits (222), Expect = 5e-18
Identities = 49/189 (25%), Positives = 83/189 (43%), Gaps = 12/189 (6%)
Query: 174 CQESL---SSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQEL-DACSFKPCKNNGSCI 229
C+E + +S C +G C + ++C+C P F+G C +L D C+ PC + G+C
Sbjct: 427 CEEKVDPCASSPCQNNGTCYVDGVH--FTCNCSPGFTGPTCAQLIDFCALSPCAH-GTCR 483
Query: 230 NKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGP 289
+ + Y+C+C P + G C E +C C + N + C C ++ G
Sbjct: 484 SVGTS-----YKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGT 538
Query: 290 FCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIK 349
CE+ PC ++ C + T C G + + + D++E PC +G C+
Sbjct: 539 HCELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLD 598
Query: 350 ISNDVMCIC 358
N C C
Sbjct: 599 QPNGYNCHC 607
Score = 70.5 bits (171), Expect = 4e-12
Identities = 34/104 (32%), Positives = 51/104 (49%), Gaps = 11/104 (10%)
Query: 217 CSFKPCKNNGSCINKREN-------WDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGN 269
C+ +PC+N G C ++ E E Y C C +G NC + C + C HGN
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
Query: 270 CSNITSNS---FICECDEQFSGPFCEVSAKPCVSLLFWKRGICP 310
CS+ +S+S ++C C+E + GP CE A P + W + P
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNCE-QALPSLPATGWTESMAP 150
Score = 63.2 bits (152), Expect = 7e-10
Identities = 46/165 (27%), Positives = 60/165 (36%), Gaps = 47/165 (28%)
Query: 181 EFCS----GHGKCLSEAWSKTYSCHCQPPFSGKYCQE-LDACSFKPCKN----------- 224
+FC+ HG C S S Y C C P + G YC+E + C PC N
Sbjct: 470 DFCALSPCAHGTCRSVGTS--YKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGY 527
Query: 225 ---------------------NGSCINKRE-NWDEQAYECVCHPPFTGKNCSEIIGQCQP 262
N SC+N + D C+C P FTG+ C I +C
Sbjct: 528 ECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDS 587
Query: 263 HVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRG 307
+ C HG N + C C + G CE+ L WK G
Sbjct: 588 NPCHHGGSCLDQPNGYNCHCPHGWVGANCEIH-------LQWKSG 625
Score = 43.1 bits (100), Expect = 8e-04
Identities = 20/61 (32%), Positives = 32/61 (52%), Gaps = 3/61 (4%)
Query: 198 YSCHCQPPFSGKYCQEL-DACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEI 256
YSC C SG CQ + D C+ PC ++G+C + + Y C+C+ + G NC +
Sbjct: 78 YSCTCPAGISGANCQLVADPCASNPC-HHGNCSSSSSS-SSDGYLCICNEGYEGPNCEQA 135
Query: 257 I 257
+
Sbjct: 136 L 136
Score = 30.8 bits (68), Expect = 3.9
Identities = 29/128 (22%), Positives = 42/128 (32%), Gaps = 21/128 (16%)
Query: 297 PCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISND--- 353
P ++LL G P SS P S G PC+NG C
Sbjct: 15 PALALLLLLLGAGPRGSSLAN-PVPAAPLSAPGPCAAQ-----PCRNGGVCTSRPEPDPQ 68
Query: 354 ---------VMCICSPIFTDLLCKSIQTSCESFPLRN---NATCKKCEKDYPCSCISGFT 401
C C + C+ + C S P + +++ Y C C G+
Sbjct: 69 HPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYE 128
Query: 402 EKNCEKAI 409
NCE+A+
Sbjct: 129 GPNCEQAL 136
>gi|148833508 notch1 preproprotein [Homo sapiens]
Length = 2555
Score = 162 bits (409), Expect = 1e-39
Identities = 121/433 (27%), Positives = 165/433 (38%), Gaps = 64/433 (14%)
Query: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQAYE 241
C G C + + Y C C+ FSG CQ ++ C+ PC N G+CI+ D Y+
Sbjct: 762 CVNGGTC--KDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCID-----DVAGYK 814
Query: 242 CVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSN--SFICECDEQFSGPFCEVSAKPCV 299
C C P+TG C ++ C P C +G + + SF C C + G CEV CV
Sbjct: 815 CNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECV 874
Query: 300 SLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICS 359
C N+ Y C G S +N ETD+ + PC NG C N C C
Sbjct: 875 LSPCRHGASCQNTHGGYRCHCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCL 934
Query: 360 PIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINC 419
P F C+ C S P RN A C C Y C+C +GF+ +CE C +C
Sbjct: 935 PGFRGTFCEEDINECASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTPDC--TESSC 992
Query: 420 LNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEY 479
N C + I F +C PG T + C +V C G G CQD G +
Sbjct: 993 FNGGTCVDGINSFTCLCPPGFTGSYC--QHDVNECDSQPCLHG----GTCQD-GCGSYRC 1045
Query: 480 VWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANG- 538
G+ G CQ ++ C + P N CW H + C +G
Sbjct: 1046 TCPQGYT---GPNCQNLVHW-------CD------SSPCKNGGKCWQTHTQYRCECPSGW 1089
Query: 539 -----------CSCLSEEDSQEYRYLC----FLRWAGN------------MYLENTTDD- 570
C ++ + LC AGN Y E+ D+
Sbjct: 1090 TGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDEC 1149
Query: 571 QENECQHEAVCKD 583
+ CQ+ A C D
Sbjct: 1150 SPSPCQNGATCTD 1162
Score = 144 bits (364), Expect = 2e-34
Identities = 121/491 (24%), Positives = 183/491 (37%), Gaps = 95/491 (19%)
Query: 144 GTHYFITVMASGPSPCPLGLRLNVTVKQQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQ 203
GTH + + P PC G C++ ++ T++C C+
Sbjct: 560 GTHCEVDIDECDPDPCHYGS----------CKDGVA-----------------TFTCLCR 592
Query: 204 PPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQP 262
P ++G +C+ ++ CS +PC++ G+C ++ + AY C C TG NC + C
Sbjct: 593 PGYTGHHCETNINECSSQPCRHGGTCQDR-----DNAYLCFCLKGTTGPNCEINLDDCAS 647
Query: 263 HVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPK 322
C G C + + + C C+ ++G C ++ C G C + + +T CP+
Sbjct: 648 SPCDSGTCLD-KIDGYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPE 706
Query: 323 GSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNN 382
G ++V+E + PC +G C N C C P ++ C CES P N
Sbjct: 707 GYHDPTCLSEVNECNSNPCVHGA-CRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNG 765
Query: 383 ATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTK 442
TCK Y C+C GF+ NC+ I+ C S CLN+ C + + +K C+ T
Sbjct: 766 GTCKDMTSGYVCTCREGFSGPNCQTNINECA--SNPCLNQGTCIDDVAGYKCNCLLPYTG 823
Query: 443 NPCWFLKNVYLIHQHLCYCGVT---FHGIC-QDKGPAQFEYVWQLGFAGS---------- 488
C + L C + G C Q + F V G+ G
Sbjct: 824 ATCEVV---------LAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECV 874
Query: 489 -----EGEKCQGVIDAYF------FLAANCTEDATYVN-DPEDNNSSCW----------- 525
G CQ Y + NC D +P N SC
Sbjct: 875 LSPCRHGASCQNTHGGYRCHCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCL 934
Query: 526 ------FPHEGTKEI----CANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENEC 575
F E E C NG +C DS Y C ++G NT D E+ C
Sbjct: 935 PGFRGTFCEEDINECASDPCRNGANCTDCVDS--YTCTCPAGFSGIHCENNTPDCTESSC 992
Query: 576 QHEAVCKDEIN 586
+ C D IN
Sbjct: 993 FNGGTCVDGIN 1003
Score = 143 bits (360), Expect = 5e-34
Identities = 116/465 (24%), Positives = 169/465 (36%), Gaps = 76/465 (16%)
Query: 159 CPLGLR-LNVTVKQQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDA 216
CP G ++ C ES C G C+ +++C C P F+G YCQ +++
Sbjct: 971 CPAGFSGIHCENNTPDCTESS----CFNGGTCVDGI--NSFTCLCPPGFTGSYCQHDVNE 1024
Query: 217 CSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSN 276
C +PC + G+C + + Y C C +TG NC ++ C C +G T
Sbjct: 1025 CDSQPCLHGGTCQDGCGS-----YRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHT 1079
Query: 277 SFICECDEQFSGPFCEVSAKPC----------VSLLFWKRGICPNSSSAYTYECPKGSSS 326
+ CEC ++G +C+V + C V+ L G+C ++ + + C G +
Sbjct: 1080 QYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTG 1139
Query: 327 QNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCK 386
E V E S PCQNG C C C + + C C S P +N TC
Sbjct: 1140 SYCEDLVDECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGTCL 1199
Query: 387 KCEKDYPCSCISGFTEKNCEKAIDHCK------LLSINCLNEEWCFNIIGRFKYVCIPG- 439
Y CSC G +CE +D C S C N C + +G + C PG
Sbjct: 1200 DLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGF 1259
Query: 440 -----------CTKNPC---WFLKNVYLIHQHLCYCGVTFHG-------------ICQDK 472
C NPC V ++ C C G C++
Sbjct: 1260 VGERCEGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNG 1319
Query: 473 GPAQFEYVWQLGF-----AGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFP 527
G GF AG EG C+ DA + C T ++ P C P
Sbjct: 1320 GTCAVASNTARGFICKCPAGFEGATCEN--DARTCGSLRCLNGGTCISGPRSPTCLCLGP 1377
Query: 528 HEGTK------------EICANGCSCLSEEDSQEYRYLCFLRWAG 560
G + C N +C +S YR LC ++ G
Sbjct: 1378 FTGPECQFPASSPCLGGNPCYNQGTCEPTSESPFYRCLCPAKFNG 1422
Score = 142 bits (358), Expect = 9e-34
Identities = 105/418 (25%), Positives = 170/418 (40%), Gaps = 53/418 (12%)
Query: 187 GKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQAYECVCH 245
G CL + Y C C+P ++G C +D C+ PC N G+C + + C C
Sbjct: 653 GTCLDKI--DGYECACEPGYTGSMCNINIDECAGNPCHNGGTCED-----GINGFTCRCP 705
Query: 246 PPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWK 305
+ C + +C + C HG C + + N + C+CD +SG C+++ C S
Sbjct: 706 EGYHDPTCLSEVNECNSNPCVHGACRD-SLNGYKCDCDPGWSGTNCDINNNECESNPCVN 764
Query: 306 RGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDL 365
G C + +S Y C +G S N +T+++E + PC N CI C C +T
Sbjct: 765 GGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDVAGYKCNCLLPYTGA 824
Query: 366 LCKSIQTSCESFPLRNNATCKKCE--KDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEE 423
C+ + C P RN C++ E + + C C +G+ + CE I+ C L C +
Sbjct: 825 TCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSP--CRHGA 882
Query: 424 WCFNIIGRFKYVC------------IPGCTKNPCWFLKN-VYLIHQHLCYCGVTFHG-IC 469
C N G ++ C I C NPC + I+ C C F G C
Sbjct: 883 SCQNTHGGYRCHCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFC 942
Query: 470 QDKGPAQFEYVWQLGFAGSE----GEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCW 525
++ + S+ G C +D+Y CT A + +NN+
Sbjct: 943 EE----------DINECASDPCRNGANCTDCVDSY-----TCTCPAGFSGIHCENNTP-- 985
Query: 526 FPHEGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKD 583
+ T+ C NG +C+ +S + LC + G+ + + C H C+D
Sbjct: 986 ---DCTESSCFNGGTCVDGINS--FTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQD 1038
Score = 132 bits (332), Expect = 9e-31
Identities = 117/425 (27%), Positives = 164/425 (38%), Gaps = 43/425 (10%)
Query: 183 CSGHGKC--LSEAWSKTYSCHCQPPFSGKYC-QELD-ACSFKPCKNNGSCINKRENWDEQ 238
C G C + Y+C C FSG C LD AC PC+N G+C +
Sbjct: 68 CKNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNACLTNPCRNGGTC----DLLTLT 123
Query: 239 AYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPC 298
Y+C C P ++GK+C + C + C +G S+IC C F GP C C
Sbjct: 124 EYKCRCPPGWSGKSCQQA-DPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNEC 182
Query: 299 VSL--LFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVM- 355
L G C N +Y C + N E S PCQNG C + + DV
Sbjct: 183 GQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTC-RPTGDVTH 241
Query: 356 -CICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKL 414
C C P FT C+ C +N C Y C C +T + C + +D C+L
Sbjct: 242 ECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQL 301
Query: 415 LSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGP 474
+ C N C N G + VC+ G T C +N+ C+ G T C D+
Sbjct: 302 MPNACQNGGTCHNTHGGYNCVCVNGWTGEDC--SENIDDCASAACFHGAT----CHDR-V 354
Query: 475 AQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEI 534
A F G G C + DA ++ C E + +P + + C P T
Sbjct: 355 ASFYCECP---HGRTGLLCH-LNDA--CISNPCNEGSNCDTNPVNGKAICTCPSGYTGPA 408
Query: 535 C----------ANGC----SCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAV 580
C AN C C++ S E + C + G + + N CQ++A
Sbjct: 409 CSQDVDECSLGANPCEHAGKCINTLGSFECQ--CLQGYTGPRCEIDVNECVSNPCQNDAT 466
Query: 581 CKDEI 585
C D+I
Sbjct: 467 CLDQI 471
Score = 129 bits (325), Expect = 6e-30
Identities = 112/436 (25%), Positives = 168/436 (38%), Gaps = 46/436 (10%)
Query: 174 CQESLSSEFCSGH-GKCLSEAWSKTYSCH-------CQPPF--SGKYCQELDACSFKPCK 223
C + E CS + C S A +CH C+ P +G C DAC PC
Sbjct: 323 CVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCECPHGRTGLLCHLNDACISNPCN 382
Query: 224 NNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQ--PHVCFH-GNCSNITSNSFIC 280
+C N C C +TG CS+ + +C + C H G C N T SF C
Sbjct: 383 EGSNCDTNPVNGKAI---CTCPSGYTGPACSQDVDECSLGANPCEHAGKCIN-TLGSFEC 438
Query: 281 ECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVP 340
+C + ++GP CE+ CVS C + + C G + E + E + P
Sbjct: 439 QCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSP 498
Query: 341 CQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGF 400
C + C+ N+ C C FT LC+ C S P +N A C Y C C G+
Sbjct: 499 CLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGY 558
Query: 401 TEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCY 460
T +CE ID C + + C + + F +C PG T + C N+ C
Sbjct: 559 TGTHCEVDIDEC---DPDPCHYGSCKDGVATFTCLCRPGYTGHHC--ETNINECSSQPCR 613
Query: 461 CGVTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDN 520
G G CQD+ A + G+ G C+ +D A++ + T ++ +
Sbjct: 614 HG----GTCQDRDNAYLCFC----LKGTTGPNCEINLDD---CASSPCDSGTCLDKIDGY 662
Query: 521 NSSCWFPHEGTK----------EICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDD 570
+C + G+ C NG +C E+ + C + L +
Sbjct: 663 ECACEPGYTGSMCNINIDECAGNPCHNGGTC--EDGINGFTCRCPEGYHDPTCLSEVNEC 720
Query: 571 QENECQHEAVCKDEIN 586
N C H A C+D +N
Sbjct: 721 NSNPCVHGA-CRDSLN 735
Score = 126 bits (317), Expect = 5e-29
Identities = 83/297 (27%), Positives = 126/297 (42%), Gaps = 35/297 (11%)
Query: 198 YSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEI 256
Y CHCQ +SG+ C+ ++D C PC N GSC + A+ C C P F G C E
Sbjct: 891 YRCHCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINT----AF-CDCLPGFRGTFCEED 945
Query: 257 IGQCQPHVCFHG-NCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSA 315
I +C C +G NC++ +S+ C C FSG CE + C + G C + ++
Sbjct: 946 INECASDPCRNGANCTDCV-DSYTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVDGINS 1004
Query: 316 YTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCE 375
+T CP G + + DV+E PC +G C C C +T C+++ C+
Sbjct: 1005 FTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCD 1064
Query: 376 SFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKL-----------------LSIN 418
S P +N C + Y C C SG+T C+ C++ L ++
Sbjct: 1065 SSPCKNGGKCWQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVD 1124
Query: 419 CLNEEWCFNIIGRFKYVC---IPGCTKNPCWFLKNVYLIHQHL----CYCGVTFHGI 468
N C G C + C+ +PC +N +L C C +HG+
Sbjct: 1125 AGNTHHCRCQAGYTGSYCEDLVDECSPSPC---QNGATCTDYLGGYSCKCVAGYHGV 1178
Score = 65.1 bits (157), Expect = 2e-10
Identities = 71/282 (25%), Positives = 102/282 (36%), Gaps = 50/282 (17%)
Query: 326 SQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATC 385
SQ GET C NG C + C+C F C+ C S P +N TC
Sbjct: 25 SQPGET---------CLNGGKCEAANGTEACVCGGAFVGPRCQD-PNPCLSTPCKNAGTC 74
Query: 386 KKCEK----DYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNI-IGRFKYVCIPG- 439
++ DY CSC GF+ C +D+ L + C N C + + +K C PG
Sbjct: 75 HVVDRRGVADYACSCALGFSGPLCLTPLDNACLTN-PCRNGGTCDLLTLTEYKCRCPPGW 133
Query: 440 ----------CTKNPCWFLKNVYLIH-QHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGS 488
C NPC ++C+C +FHG P + V + G
Sbjct: 134 SGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFHG------PTCRQDVNECGQKPG 187
Query: 489 ---EGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEG-TKEICANGCSCLSE 544
G C + +Y C AT+ +C P+ + C NG +C
Sbjct: 188 LCRHGGTCHNEVGSY-----RCVCRATHTGP------NCERPYVPCSPSPCQNGGTCRPT 236
Query: 545 EDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEIN 586
D + C + G EN D N C++ C D +N
Sbjct: 237 GDVT-HECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVN 277
Score = 30.0 bits (66), Expect = 6.6
Identities = 45/173 (26%), Positives = 60/173 (34%), Gaps = 37/173 (21%)
Query: 154 SGP-SPCPLGLRLNVTVKQQFCQES--LSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKY 210
SGP SP L L + QF S L C G C + S Y C C F+G
Sbjct: 1365 SGPRSPTCLCLGPFTGPECQFPASSPCLGGNPCYNQGTCEPTSESPFYRCLCPAKFNGLL 1424
Query: 211 CQELD------------------ACSFKPCKNNG-------SCINKRENWDEQAYECVCH 245
C LD AC C+ + C N WD +C +
Sbjct: 1425 CHILDYSFGGGAGRDIPPPLIEEACELPECQEDAGNKVCSLQCNNHACGWD--GGDCSLN 1482
Query: 246 PPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPC 298
KNC++ + QC + G+C + NS C F G C+ + C
Sbjct: 1483 FNDPWKNCTQSL-QCWKYFS-DGHCDS-QCNSAGC----LFDGFDCQRAEGQC 1528
>gi|4557679 jagged 1 precursor [Homo sapiens]
Length = 1218
Score = 157 bits (398), Expect = 2e-38
Identities = 117/428 (27%), Positives = 166/428 (38%), Gaps = 44/428 (10%)
Query: 172 QFCQESLSSEFCSGHGKCL-----SEAWSKTYSCHCQPPFSGKYCQELD-ACSFKPCKNN 225
Q C + L+ +C H CL S Y C C +SG C+ + AC PC N
Sbjct: 291 QLCDKDLN--YCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNR 348
Query: 226 GSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQ 285
GSC +EC C P +TG CS I C P+ C HG N F C C Q
Sbjct: 349 GSCKET-----SLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQ 403
Query: 286 FSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGT 345
++G C++ A C + C N ++Y +C G QN + ++++ L CQN
Sbjct: 404 WTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININD-CLGQCQNDA 462
Query: 346 DCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNC 405
C + N CIC P + C+ C S P N C+ + C C +GF+ C
Sbjct: 463 SCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLC 522
Query: 406 EKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTF 465
+ ID+C+ C N C+N + C C LK+ H C V
Sbjct: 523 QLDIDYCE--PNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKD----HCRTTPCEVID 576
Query: 466 H---GICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATY----VNDPE 518
+ + P Y+ G G KC+ F N TY +ND E
Sbjct: 577 SCTVAMASNDTPEGVRYI-SSNVCGPHG-KCKSQSGGKFTCDCNKGFTGTYCHENINDCE 634
Query: 519 DNNSSCWFPHEGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHE 578
N C NG +C+ +S Y+ +C W G N D +N C +
Sbjct: 635 SNP-------------CRNGGTCIDGVNS--YKCICSDGWEGAYCETNINDCSQNPCHNG 679
Query: 579 AVCKDEIN 586
C+D +N
Sbjct: 680 GTCRDLVN 687
Score = 149 bits (377), Expect = 6e-36
Identities = 118/458 (25%), Positives = 183/458 (39%), Gaps = 82/458 (17%)
Query: 174 CQESLSSEFCSG-HGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKR 232
C ++ + CS HG C C CQ + G YC D C P +G C
Sbjct: 229 CNRAICRQGCSPKHGSCKLPG-----DCRCQYGWQGLYC---DKCIPHPGCVHGIC---- 276
Query: 233 ENWDEQAYECVCHPPFTGKNCSEIIGQCQPHV-CFHGN-CSNITSNSFICECDEQFSGPF 290
+ ++C+C + G+ C + + C H C +G CSN + + C C E +SGP
Sbjct: 277 ----NEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPN 332
Query: 291 CEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKI 350
CE++ C+S RG C +S + EC G + T++ + S C +G C +
Sbjct: 333 CEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDL 392
Query: 351 SNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAID 410
N C+C P +T C+ CE+ P N +CK Y C C+ G+ +NC+ I+
Sbjct: 393 VNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININ 452
Query: 411 HCKLLSINCLNEEWCFNIIGRFKYVCIPG------------CTKNPCWFLKNVYL---IH 455
C C N+ C +++ ++ +C PG C NPC L + I+
Sbjct: 453 DC---LGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPC--LNGGHCQNEIN 507
Query: 456 QHLCYCGVTFHG-ICQ------DKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCT 508
+ C C F G +CQ + P Q G +C YF C
Sbjct: 508 RFQCLCPTGFSGNLCQLDIDYCEPNPCQ------------NGAQCYNRASDYF---CKCP 552
Query: 509 ED-----ATYVND-----PEDNNSSCWF------PHEGTKEICANGC----SCLSEEDSQ 548
ED +++ D P + SC EG + I +N C C S+
Sbjct: 553 EDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGG- 611
Query: 549 EYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEIN 586
++ C + G EN D + N C++ C D +N
Sbjct: 612 KFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVN 649
Score = 130 bits (327), Expect = 4e-30
Identities = 110/434 (25%), Positives = 168/434 (38%), Gaps = 83/434 (19%)
Query: 187 GKCLSEAWSKT----YSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQAYE 241
G+C ++A + Y C C P ++G +C+ ++D C+ PC N G C N+ ++
Sbjct: 456 GQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINR-----FQ 510
Query: 242 CVCHPPFTGKNCSEIIGQCQPHVCFHG-NCSNITSNSFICECDEQFSGPFCE-----VSA 295
C+C F+G C I C+P+ C +G C N S+ F C+C E + G C
Sbjct: 511 CLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYF-CKCPEDYEGKNCSHLKDHCRT 569
Query: 296 KPCV----------------------SLLFWKRGICPNSSSA-YTYECPKGSSSQNGETD 332
PC S + G C + S +T +C KG + +
Sbjct: 570 TPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHEN 629
Query: 333 VSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDY 392
+++ PC+NG CI N CICS + C++ C P N TC+ D+
Sbjct: 630 INDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDF 689
Query: 393 PCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVY 452
C C +G+ K C C C N C++ FK +C G C +N
Sbjct: 690 YCDCKNGWKGKTCHSRDSQCD--EATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSS 747
Query: 453 LIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDAT 512
+ + C+ G G C G + F V + G+ G + A T D +
Sbjct: 748 CL-PNPCHNG----GTCVVNGES-FTCVCKEGWEGP--------------ICAQNTNDCS 787
Query: 513 YVNDPEDNNSSCWFPHEGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQE 572
PH C N +C+ ++ YR C +AG N + Q
Sbjct: 788 --------------PHP-----CYNSGTCVDGDNW--YRCECAPGFAGPDCRININECQS 826
Query: 573 NECQHEAVCKDEIN 586
+ C A C DEIN
Sbjct: 827 SPCAFGATCVDEIN 840
Score = 129 bits (325), Expect = 6e-30
Identities = 112/454 (24%), Positives = 167/454 (36%), Gaps = 70/454 (15%)
Query: 176 ESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDA--CSFKPCKNNGSCINKRE 233
+ S CS G C + + C C P ++GK CQ LDA C KPC N SC N
Sbjct: 376 DDCSPNNCSHGGTC--QDLVNGFKCVCPPQWTGKTCQ-LDANECEAKPCVNAKSCKNLIA 432
Query: 234 NWDEQAYECVCHPPFTGKNC----SEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGP 289
+ Y C C P + G+NC ++ +GQCQ +C ++ N + C C ++G
Sbjct: 433 S-----YYCDCLPGWMGQNCDININDCLGQCQNDA----SCRDLV-NGYRCICPPGYAGD 482
Query: 290 FCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIK 349
CE C S G C N + + CP G S + D+ PCQNG C
Sbjct: 483 HCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYN 542
Query: 350 ISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCK----------------------- 386
++D C C + C ++ C + P +C
Sbjct: 543 RASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPH 602
Query: 387 -KCEKD----YPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCT 441
KC+ + C C GFT C + I+ C+ S C N C + + +K +C G
Sbjct: 603 GKCKSQSGGKFTCDCNKGFTGTYCHENINDCE--SNPCRNGGTCIDGVNSYKCICSDGWE 660
Query: 442 KNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYF 501
C N+ Q+ C+ G T + D + W+ S +C
Sbjct: 661 GAYCE--TNINDCSQNPCHNGGTCRDLVNDFY-CDCKNGWKGKTCHSRDSQCD------- 710
Query: 502 FLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCSCLSEE---------DSQEYRY 552
A C T ++ + C EGT A SCL + + +
Sbjct: 711 --EATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTC 768
Query: 553 LCFLRWAGNMYLENTTDDQENECQHEAVCKDEIN 586
+C W G + +NT D + C + C D N
Sbjct: 769 VCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDN 802
Score = 124 bits (312), Expect = 2e-28
Identities = 101/397 (25%), Positives = 147/397 (37%), Gaps = 49/397 (12%)
Query: 176 ESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKREN 234
+ +S C G C +E + C C FSG CQ ++D C PC+N C N+ +
Sbjct: 489 DECASNPCLNGGHCQNEI--NRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASD 546
Query: 235 WDEQAYECVCHPPFTGKNCSEIIGQCQPHVCF---------------------------- 266
Y C C + GKNCS + C+ C
Sbjct: 547 -----YFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGP 601
Query: 267 HGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSS 326
HG C + + F C+C++ F+G +C + C S G C + ++Y C G
Sbjct: 602 HGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEG 661
Query: 327 QNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCK 386
ET++++ S PC NG C + ND C C + C S + C+ N TC
Sbjct: 662 AYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCY 721
Query: 387 KCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCW 446
+ C C G+ C A + L C N C F VC G C
Sbjct: 722 DEGDAFKCMCPGGWEGTTCNIA-RNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPIC- 779
Query: 447 FLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAAN 506
+N H CY G C D G + GFAG + C+ I+ ++
Sbjct: 780 -AQNTNDCSPHPCYNS----GTCVD-GDNWYRCECAPGFAGPD---CR--ININECQSSP 828
Query: 507 CTEDATYVNDPEDNNSSCWFPHEGTKEICANGCSCLS 543
C AT V++ C H G K +G C++
Sbjct: 829 CAFGATCVDEINGYRCVCPPGHSGAKCQEVSGRPCIT 865
Score = 53.1 bits (126), Expect = 7e-07
Identities = 104/438 (23%), Positives = 145/438 (33%), Gaps = 94/438 (21%)
Query: 191 SEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWD-----------EQA 239
S AW ++Y+ + S + D+ K ++ IN W E
Sbjct: 125 SFAWPRSYTLLVEAWDSSNDTVQPDSIIEKA--SHSGMINPSRQWQTLKQNTGVAHFEYQ 182
Query: 240 YECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCV 299
C + G C++ C+P F G+ + + + C E + GP C
Sbjct: 183 IRVTCDDYYYGFGCNKF---CRPRDDFFGHYACDQNGNKTCM--EGWMGPECN------- 230
Query: 300 SLLFWKRGICPNSSSAYTYEC--PKGSSSQNGETDVSEFSLVP---CQNGTDCIKISNDV 354
R IC S C P Q G + +P C +G I N+
Sbjct: 231 ------RAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHG-----ICNEP 279
Query: 355 -MCICSPIFTDLLCKSIQTSCESF-PLRNNATCKKCEKD-YPCSCISGFTEKNCEKAIDH 411
C+C + LC C + P N TC D Y CSC G++ NCE A
Sbjct: 280 WQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHA 339
Query: 412 CKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQD 471
C LS C N C F+ C PG T C N+ + C G G CQD
Sbjct: 340 C--LSDPCHNRGSCKETSLGFECECSPGWTGPTC--STNIDDCSPNNCSHG----GTCQD 391
Query: 472 KGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFP-HEG 530
G KC V P+ +C +E
Sbjct: 392 L---------------VNGFKC--------------------VCPPQWTGKTCQLDANEC 416
Query: 531 TKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRR 590
+ C N SC + S Y C W G + +D +CQ++A C+D +N R
Sbjct: 417 EAKPCVNAKSCKNLIAS--YYCDCLPGWMGQN-CDININDCLGQCQNDASCRDLVNGYRC 473
Query: 591 ILNTVIPHQIQQHIERFI 608
I P H ER I
Sbjct: 474 ICP---PGYAGDHCERDI 488
Score = 42.4 bits (98), Expect = 0.001
Identities = 30/93 (32%), Positives = 38/93 (40%), Gaps = 15/93 (16%)
Query: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYEC 242
C+ C+ E Y C C P SG CQE+ S +PC GS I WD+ C
Sbjct: 829 CAFGATCVDEI--NGYRCVCPPGHSGAKCQEV---SGRPCITMGSVIPDGAKWDDDCNTC 883
Query: 243 VCHPPFTGK-NCSEIIGQCQPHVCF----HGNC 270
C G+ CS++ C P C H C
Sbjct: 884 QC---LNGRIACSKV--WCGPRPCLLHKGHSEC 911
>gi|110735443 delta-like 1 [Homo sapiens]
Length = 723
Score = 155 bits (391), Expect = 1e-37
Identities = 87/280 (31%), Positives = 123/280 (43%), Gaps = 15/280 (5%)
Query: 172 QFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYC-QELDACSF-KPCKNNGSCI 229
++C E + C HG C + + C+CQ + G +C Q+L+ C+ KPCKN +C
Sbjct: 252 RYCDECIRYPGCL-HGTC-----QQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCT 305
Query: 230 NKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGP 289
N + +Y C C P +TG C I +C P C +G NS+ C C F G
Sbjct: 306 NTGQG----SYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGK 361
Query: 290 FCEVSAKPCVSLLFWKRGICPNS-SSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCI 348
CE+SA C + G C +S Y+ CP G S N E + S PC NG C+
Sbjct: 362 ICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCV 421
Query: 349 KISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKA 408
+ + +C C F+ C C S P N TC+ D+ C+C G+T +NC
Sbjct: 422 DLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAP 481
Query: 409 IDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFL 448
+ C+ C N C R+ C G C FL
Sbjct: 482 VSRCE--HAPCHNGATCHERGHRYVCECARGYGGPNCQFL 519
Score = 60.1 bits (144), Expect = 6e-09
Identities = 75/331 (22%), Positives = 111/331 (33%), Gaps = 72/331 (21%)
Query: 282 CDEQFSGPFCEVSAKP----CVSLLFWKRG--IC-PNSSSAYTYE--CPKGSSSQNGETD 332
CDE + G C V +P +RG +C P Y E C G Q+G D
Sbjct: 179 CDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCD 238
Query: 333 VSEFSLVPCQNG------TDCIKISNDV--------MCICSPIFTDLLCKSIQTSCESF- 377
+ C+ G +CI+ + C C + L C C
Sbjct: 239 --KPGECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHK 296
Query: 378 PLRNNATCKKC-EKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVC 436
P +N ATC + Y CSC G+T CE ID C C N C ++ + C
Sbjct: 297 PCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECD--PSPCKNGGSCTDLENSYSCTC 354
Query: 437 IPGCTKNPCWFLKNVYLIHQHLCYCGVTFH-GICQDKGPAQFEYVWQLGFAGSEGEKCQG 495
PG F + + C G F+ G C D + +G++G
Sbjct: 355 PPG-------FYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSG-------- 399
Query: 496 VIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCSCLSEEDSQEYRYLCF 555
NC + Y + C+NG C+ D+ Y C
Sbjct: 400 ---------FNCEKKIDYCSSSP----------------CSNGAKCVDLGDA--YLCRCQ 432
Query: 556 LRWAGNMYLENTTDDQENECQHEAVCKDEIN 586
++G +N D + C + C+D +N
Sbjct: 433 AGFSGRHCDDNVDDCASSPCANGGTCRDGVN 463
Score = 46.6 bits (109), Expect = 7e-05
Identities = 36/139 (25%), Positives = 52/139 (37%), Gaps = 41/139 (29%)
Query: 159 CPLGLR-LNVTVKQQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQE-LDA 216
CP+G N K +C SS CS KC+ Y C CQ FSG++C + +D
Sbjct: 393 CPVGYSGFNCEKKIDYC----SSSPCSNGAKCVD--LGDAYLCRCQAGFSGRHCDDNVDD 446
Query: 217 CSFKPCKNNGSCINKRENWD-------------------EQA--------------YECV 243
C+ PC N G+C + ++ E A Y C
Sbjct: 447 CASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCE 506
Query: 244 CHPPFTGKNCSEIIGQCQP 262
C + G NC ++ + P
Sbjct: 507 CARGYGGPNCQFLLPELPP 525
>gi|24041035 notch 2 preproprotein [Homo sapiens]
Length = 2471
Score = 154 bits (388), Expect = 3e-37
Identities = 116/423 (27%), Positives = 173/423 (40%), Gaps = 49/423 (11%)
Query: 186 HGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQAYECVC 244
HG C+ YSC C P F+G+ C ++D C+ PC+ +CIN + C+C
Sbjct: 656 HGICMDGI--NRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCIN-----GVNGFRCIC 708
Query: 245 HPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFW 304
+C + +C + C HGNC+ S + C CD + G CEV C+S
Sbjct: 709 PEGPHHPSCYSQVNECLSNPCIHGNCTGGLSG-YKCLCDAGWVGINCEVDKNECLSNPCQ 767
Query: 305 KRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTD 364
G C N + Y C KG N + ++ E + PC N C + C C +T
Sbjct: 768 NGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTG 827
Query: 365 LLCKSIQTSCESFPLRNNATCKKCE--KDYPCSCISGFTEKNCEKAIDHCKLLSINCLNE 422
C+++ C P N A CK+ + Y C C G+ + C ID C +S C+N
Sbjct: 828 KNCQTVLAPCSPNPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDEC--ISKPCMNH 885
Query: 423 EWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQ 482
C N G + C PG + C +++ + C G G C D G F +
Sbjct: 886 GLCHNTQGSYMCECPPGFSGMDC--EEDIDDCLANPCQNG----GSCMD-GVNTFSCLCL 938
Query: 483 LGFAGSEGEKCQGVIDAYFFLAANCTEDAT---YVND-------------PEDNNSSCWF 526
GF G+KCQ D L+ C T YVN E+N + C
Sbjct: 939 PGFT---GDKCQ--TDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINEC-- 991
Query: 527 PHEGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEIN 586
T+ C NG +C+ +S + LC + + G+ L + + C +E C D +
Sbjct: 992 ----TESSCFNGGTCVDGINS--FSCLCPVGFTGSFCLHEINECSSHPCLNEGTCVDGLG 1045
Query: 587 RPR 589
R
Sbjct: 1046 TYR 1048
Score = 144 bits (363), Expect = 2e-34
Identities = 119/453 (26%), Positives = 171/453 (37%), Gaps = 71/453 (15%)
Query: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYEC 242
C+ C+ S +SC C +G C DAC PC C N Y C
Sbjct: 347 CTPGSTCIDRVAS--FSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQ---YIC 401
Query: 243 VCHPPFTGKNCSEIIGQC---QPHVCFH-GNCSNITSNSFICECDEQFSGPFCEVSAKPC 298
C + G +C+E + +C + C H G C N T +F CEC + ++GP CE+ C
Sbjct: 402 TCPQGYKGADCTEDVDECAMANSNPCEHAGKCVN-TDGAFHCECLKGYAGPRCEMDINEC 460
Query: 299 VSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCIC 358
S C + +T C G + E +++E PC N C+ N C+C
Sbjct: 461 HSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLC 520
Query: 359 SPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHC------ 412
P FT +C+ C S P N A C Y C C +GFT CE+ ID+C
Sbjct: 521 PPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCH 580
Query: 413 -----------------------------KLLSINCLNEEWCFNIIGRFKYVCIPGCTKN 443
+ S CLN+ C +++ ++ C PG +
Sbjct: 581 HGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGV 640
Query: 444 PCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFL 503
C I+ C HGIC D G ++ V GF G++C ID
Sbjct: 641 NC-------EINFDDCASNPCIHGICMD-GINRYSCVCSPGFT---GQRCNIDIDE---C 686
Query: 504 AAN-CTEDATYVNDPEDNNSSCWFPHEGTKEICANGCS-CLSEE--------DSQEYRYL 553
A+N C + AT +N N C P C + + CLS Y+ L
Sbjct: 687 ASNPCRKGATCINGV--NGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCL 744
Query: 554 CFLRWAGNMYLENTTDDQENECQHEAVCKDEIN 586
C W G + + N CQ+ C + +N
Sbjct: 745 CDAGWVGINCEVDKNECLSNPCQNGGTCDNLVN 777
Score = 140 bits (353), Expect = 3e-33
Identities = 112/425 (26%), Positives = 170/425 (40%), Gaps = 43/425 (10%)
Query: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQAYE 241
C C ++Y+C C P + G+ C ++D C KPC N+G C N + +Y
Sbjct: 842 CENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNT-----QGSYM 896
Query: 242 CVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSL 301
C C P F+G +C E I C + C +G N+F C C F+G C+ C+S
Sbjct: 897 CECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSE 956
Query: 302 LFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPI 361
G C + ++YT +C G + E +++E + C NG C+ N C+C
Sbjct: 957 PCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVG 1016
Query: 362 FTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLN 421
FT C C S P N TC Y CSC G+T KNC+ ++ C C N
Sbjct: 1017 FTGSFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCS--RSPCKN 1074
Query: 422 EEWCFNIIGRFKYVCIPGCTKNPCWFLKNVY---------LIHQHLCYCGVTFHGICQDK 472
+ C + +C G C + NV ++ +HLC G+C +
Sbjct: 1075 KGTCVQKKAESQCLCPSGWAGAYC-DVPNVSCDIAASRRGVLVEHLC----QHSGVCINA 1129
Query: 473 GPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAAN-CTEDATYVNDPEDNNSSCWFPHEGT 531
G + LG+ GS C+ +D A+N C AT + C ++G
Sbjct: 1130 GNTHY-CQCPLGYTGS---YCEEQLDE---CASNPCQHGATCSDFIGGYRCECVPGYQGV 1182
Query: 532 ----------KEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQEN-ECQHEAV 580
+ C NG +C+ + ++ C G + EN D C +
Sbjct: 1183 NCEYEVDECQNQPCQNGGTCI--DLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQ 1240
Query: 581 CKDEI 585
C D I
Sbjct: 1241 CMDRI 1245
Score = 140 bits (352), Expect = 5e-33
Identities = 113/436 (25%), Positives = 161/436 (36%), Gaps = 43/436 (9%)
Query: 174 CQESLS-----SEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSC 228
CQ S S S C G C + TY C CQ F+GK CQ DAC PC N +C
Sbjct: 101 CQYSTSHPCFVSRPCLNGGTCHMLS-RDTYECTCQVGFTGKECQWTDACLSHPCANGSTC 159
Query: 229 INKRENWDEQAYECVCHPPFTGKNCSEIIGQCQ-PHVCFHGNCSNITSNSFICECDEQFS 287
+ C C FTG+ C + +C P C HG S+ C+C + F+
Sbjct: 160 TTVANQ-----FSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFT 214
Query: 288 GPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECP--KGSSSQNGETDVSEFSLVPCQNGT 345
G +C+ PC G C + +T+EC G E ++ + CQNG
Sbjct: 215 GQYCDSLYVPCAPSPCVNGGTC-RQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGG 273
Query: 346 DCIKISNDVMCICSPIFTDLLCKSIQTSCESFP--LRNNATCKKCEKDYPCSCISGFTEK 403
C+ N C C P +T C C P +N TC Y C C++G++
Sbjct: 274 VCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGD 333
Query: 404 NCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIH-QHLCYCG 462
+C + ID C S C C + + F +C G K L H C
Sbjct: 334 DCSENIDDCAFAS--CTPGSTCIDRVASFSCMCPEG---------KAGLLCHLDDACISN 382
Query: 463 VTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAAN-CTEDATYVNDPEDNN 521
G D P +Y+ G +G C +D +N C VN +
Sbjct: 383 PCHKGALCDTNPLNGQYICTCP-QGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFH 441
Query: 522 SSCWFPHEGTK----------EICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQ 571
C + G + + C N +CL + + LC + G + Q
Sbjct: 442 CECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGG--FTCLCMPGFKGVHCELEINECQ 499
Query: 572 ENECQHEAVCKDEINR 587
N C + C D++NR
Sbjct: 500 SNPCVNNGQCVDKVNR 515
Score = 131 bits (329), Expect = 2e-30
Identities = 113/433 (26%), Positives = 162/433 (37%), Gaps = 50/433 (11%)
Query: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDA-CSFKPCKNNGSCINKRENWDEQAYE 241
C G CL+ S Y C C F+G+YC L C+ PC N G+C R+ D +E
Sbjct: 192 CQHGGTCLNLPGS--YQCQCPQGFTGQYCDSLYVPCAPSPCVNGGTC---RQTGDF-TFE 245
Query: 242 CVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCV-- 299
C C P F G C I C H C +G N++ C C Q++G FC C+
Sbjct: 246 CNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQ 305
Query: 300 SLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICS 359
G C N + Y C G S + ++ + + C G+ CI C+C
Sbjct: 306 PNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCP 365
Query: 360 PIFTDLLCKSIQTSCESFPLRNNATC--KKCEKDYPCSCISGFTEKNCEKAIDHCKLLSI 417
LLC + +C S P A C Y C+C G+ +C + +D C + +
Sbjct: 366 EGKAGLLC-HLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANS 424
Query: 418 N-CLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQ 476
N C + C N G F C+ G C ++ H C T C DK
Sbjct: 425 NPCEHAGKCVNTDGAFHCECLKGYAGPRCEM--DINECHSDPCQNDAT----CLDK-IGG 477
Query: 477 FEYVWQLGFAGSEGE----KCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTK 532
F + GF G E +CQ + C + V+ + N C P T
Sbjct: 478 FTCLCMPGFKGVHCELEINECQ---------SNPCVNNGQCVD--KVNRFQCLCPPGFTG 526
Query: 533 EI------------CANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAV 580
+ C NG C+ + Y C + G + EN + + C H
Sbjct: 527 PVCQIDIDDCSSTPCLNGAKCIDHPNG--YECQCATGFTGVLCEENIDNCDPDPC-HHGQ 583
Query: 581 CKDEINRPRRILN 593
C+D I+ I N
Sbjct: 584 CQDGIDSYTCICN 596
Score = 130 bits (326), Expect = 5e-30
Identities = 98/373 (26%), Positives = 157/373 (42%), Gaps = 36/373 (9%)
Query: 185 GHGKCLSEAWSKTYS-----CHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQA 239
G+ C++E TY C C F G+YCQ D C C+N G+C+ +
Sbjct: 31 GYEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKA-- 88
Query: 240 YECVCHPPFTGKNCSEIIGQCQPHVCF-------HGNCSNITSNSFICECDEQFSGPFCE 292
C C FTG++C H CF G C ++ +++ C C F+G C+
Sbjct: 89 -TCRCASGFTGEDCQ----YSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQ 143
Query: 293 VSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLV-PCQNGTDCIKIS 351
+ C+S C ++ ++ +C G + Q ETDV+E + CQ+G C+ +
Sbjct: 144 WT-DACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLP 202
Query: 352 NDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKC-EKDYPCSCISGFTEKNCEKAID 410
C C FT C S+ C P N TC++ + + C+C+ GF CE+ ID
Sbjct: 203 GSYQCQCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNID 262
Query: 411 HCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQ 470
C + C N C + + + C P T C + L+ + C G G C
Sbjct: 263 DCP--NHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNG----GTCA 316
Query: 471 DKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEG 530
++ + V G++G + C ID F A+CT +T ++ + SC P
Sbjct: 317 NRN-GGYGCVCVNGWSGDD---CSENIDDCAF--ASCTPGSTCID--RVASFSCMCPEGK 368
Query: 531 TKEICANGCSCLS 543
+C +C+S
Sbjct: 369 AGLLCHLDDACIS 381
Score = 123 bits (309), Expect = 4e-28
Identities = 80/306 (26%), Positives = 120/306 (39%), Gaps = 28/306 (9%)
Query: 178 LSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQE-LDACSFKPCKNNGSCINKRENWD 236
L C G C++ T+ C C ++G YC+E LD C+ PC++ +C +
Sbjct: 1115 LVEHLCQHSGVCINAG--NTHYCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGG-- 1170
Query: 237 EQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAK 296
Y C C P + G NC + +CQ C +G N F C C G CE +
Sbjct: 1171 ---YRCECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEENID 1227
Query: 297 PCV-SLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPC--QNGTDCIKISND 353
C G C + Y+ C G + + E D++E PC + DCI+++ND
Sbjct: 1228 DCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTND 1287
Query: 354 VMCICSPIFTDLLCKSIQTSCESFPLRNNATC---KKCEKDYPCSCISGFTEKNCEKAID 410
+C+C FT C++ C P N TC + C C GF+ C+ +
Sbjct: 1288 YLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQSSCG 1347
Query: 411 HCKLLSINCLNEEWCFNIIGRFKYV------CIPGCTKNPCWFLKNVYLIHQ---HLCYC 461
K C E C + + C GC +PC + + Q + C C
Sbjct: 1348 QVK-----CRKGEQCVHTASGPRCFCPSPRDCESGCASSPCQHGGSCHPQRQPPYYSCQC 1402
Query: 462 GVTFHG 467
F G
Sbjct: 1403 APPFSG 1408
Score = 64.7 bits (156), Expect = 2e-10
Identities = 63/288 (21%), Positives = 103/288 (35%), Gaps = 69/288 (23%)
Query: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQE-LDACSFKPCKNNGSCINKRENWDEQAYE 241
CS G + Y C C+ F+G++C+ +D C PC N G+C D +
Sbjct: 1273 CSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPD--GFI 1330
Query: 242 CVCHPPFTGKNCSEIIGQ-----------------------------CQPHVCFHGNCSN 272
C C P F+G C GQ C C HG +
Sbjct: 1331 CRCPPGFSGARCQSSCGQVKCRKGEQCVHTASGPRCFCPSPRDCESGCASSPCQHGGSCH 1390
Query: 273 ITSNS--FICECDEQFSGPFCEVSAKP-------CVSLLFWKR---GICPNSSSAYTYEC 320
+ C+C FSG CE+ P C+S + G+C + +++ +
Sbjct: 1391 PQRQPPYYSCQCAPPFSGSRCELYTAPPSTPPATCLSQYCADKARDGVCDEACNSHACQW 1450
Query: 321 PKGSSSQNGETDVSEFSL-VPCQN--GTDCIKISNDVMCICSPIFTDLLCKSIQTSCESF 377
G S E + S +PC + C ++ N V C +F + C+
Sbjct: 1451 DGGDCSLTMENPWANCSSPLPCWDYINNQCDELCNTVEC----LFDNFECQG-------- 1498
Query: 378 PLRNNATCKKCEKDYPCSCISGFTEKNCEKAI--DHCKLLSINCLNEE 423
N+ TCK Y C F + +C++ + C ++C ++
Sbjct: 1499 ---NSKTCK-----YDKYCADHFKDNHCDQGCNSEECGWDGLDCAADQ 1538
Score = 40.4 bits (93), Expect = 0.005
Identities = 24/87 (27%), Positives = 35/87 (40%), Gaps = 5/87 (5%)
Query: 174 CQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRE 233
C+ +S C G C + YSC C PPFSG C+ A P +C++ +
Sbjct: 1374 CESGCASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTA---PPSTPPATCLS--Q 1428
Query: 234 NWDEQAYECVCHPPFTGKNCSEIIGQC 260
++A + VC C G C
Sbjct: 1429 YCADKARDGVCDEACNSHACQWDGGDC 1455
>gi|9506545 delta-like 4 protein precursor [Homo sapiens]
Length = 685
Score = 137 bits (345), Expect = 3e-32
Identities = 76/260 (29%), Positives = 111/260 (42%), Gaps = 12/260 (4%)
Query: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYC-QELDACSF-KPCKNNGSCINKRENWDEQAY 240
C H C S + C C + G +C Q+L+ C+ PCKN +C N +++Y
Sbjct: 253 CIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNS----GQRSY 308
Query: 241 ECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVS 300
C C P +TG +C + +C + C +G + + C C + G CE S C
Sbjct: 309 TCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCAD 368
Query: 301 LLFWKRGICP--NSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCIC 358
+ G C N + Y ECP + N E V + PC NG C+ MC C
Sbjct: 369 SPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRC 428
Query: 359 SPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCE--KAIDHCKLLS 416
P FT C+ + C P + TC E C+C +GF+ + CE +ID C S
Sbjct: 429 RPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDAC--AS 486
Query: 417 INCLNEEWCFNIIGRFKYVC 436
C N C+ + +VC
Sbjct: 487 SPCFNRATCYTDLSTDTFVC 506
Score = 125 bits (313), Expect = 2e-28
Identities = 86/284 (30%), Positives = 121/284 (42%), Gaps = 37/284 (13%)
Query: 202 CQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQ 261
C P ++G+YCQ+ C + NG C + EC+C P + G+ C+E C
Sbjct: 208 CLPGWTGEYCQQ-PICLSGCHEQNGYC--------SKPAECLCRPGWQGRLCNE----CI 254
Query: 262 PHV-CFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRG-ICPNSSS-AYTY 318
PH C HG CS + C CDE + G FC+ C K G C NS +YT
Sbjct: 255 PHNGCRHGTCST----PWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTC 310
Query: 319 ECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFP 378
C G + + E ++SE PC+NG C + C+C P + L C+ SC P
Sbjct: 311 TCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSP 370
Query: 379 LRNNATCKKCEK--DYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFN--------- 427
N +C++ + +Y C C FT NCEK +D C S C N C N
Sbjct: 371 CFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRC--TSNPCANGGQCLNRGPSRMCRC 428
Query: 428 ---IIGRFKYVCIPGCTKNPCWFLKNVYLIHQHL-CYCGVTFHG 467
G + + + C +NPC + + L C C F G
Sbjct: 429 RPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSG 472
Score = 65.5 bits (158), Expect = 1e-10
Identities = 36/119 (30%), Positives = 60/119 (50%), Gaps = 12/119 (10%)
Query: 179 SSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDE 237
+S C+ G+CL+ S+ C C+P F+G YC+ + C+ PC + G+C + E
Sbjct: 407 TSNPCANGGQCLNRGPSRM--CRCRPGFTGTYCELHVSDCARNPCAHGGTCHDL-----E 459
Query: 238 QAYECVCHPPFTGKNCS--EIIGQCQPHVCFH-GNC-SNITSNSFICECDEQFSGPFCE 292
C C F+G+ C I C CF+ C +++++++F+C C F G CE
Sbjct: 460 NGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCE 518
Score = 33.9 bits (76), Expect = 0.46
Identities = 57/262 (21%), Positives = 81/262 (30%), Gaps = 70/262 (26%)
Query: 388 CEKDYPCSCISGFTEKNCEKAI--DHCKLLSINCLNEEWCF---NIIGRFKYVCIP--GC 440
C+ D SC+ G+T + C++ I C + C C GR CIP GC
Sbjct: 200 CQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAECLCRPGWQGRLCNECIPHNGC 259
Query: 441 TKNPC---WFLK-----NVYLIHQHLCYCGVTFH------GICQDKGPAQFEYVWQLGFA 486
C W Q L YC T H C + G + + G+
Sbjct: 260 RHGTCSTPWQCTCDEGWGGLFCDQDLNYC--THHSPCKNGATCSNSGQRSYTCTCRPGYT 317
Query: 487 GSE---------------GEKCQGVIDAYF------FLAANCTEDA-TYVNDPEDNNSSC 524
G + G C+ D Y + +C + + P N SC
Sbjct: 318 GVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSC 377
Query: 525 WFPHEG-----------------------TKEICANGCSCLSEEDSQEYRYLCFLRWAGN 561
++G T CANG CL+ S+ R C + G
Sbjct: 378 RERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCR--CRPGFTGT 435
Query: 562 MYLENTTDDQENECQHEAVCKD 583
+ +D N C H C D
Sbjct: 436 YCELHVSDCARNPCAHGGTCHD 457
>gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
Length = 1200
Score = 137 bits (345), Expect = 3e-32
Identities = 106/419 (25%), Positives = 161/419 (38%), Gaps = 37/419 (8%)
Query: 172 QFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYC-QELDAC-SFKPCKNNGSCI 229
+FC E + C HG C+ E W C+C+ + G C ++L+ C S PC N G+CI
Sbjct: 271 RFCDECVPYPGCV-HGSCV-EPWQ----CNCETNWGGLLCDKDLNYCGSHHPCTNGGTCI 324
Query: 230 NKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGP 289
N + Y C C ++G+NC + C + C +G + + F C C +SGP
Sbjct: 325 NA----EPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGP 380
Query: 290 FCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIK 349
C + C S G C + + CP+ + DV++ CQ+G C
Sbjct: 381 TCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCR-GQCQHGGTCKD 439
Query: 350 ISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAI 409
+ N C+C F C+ + C S P + C+ + C C GF+ CE +
Sbjct: 440 LVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDV 499
Query: 410 DHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGV--TFHG 467
D C+ C N C+N+ G + C C + + C G G
Sbjct: 500 DLCE--PSPCRNGARCYNLEGDYYCACPDDFGGKNC-------SVPREPCPGGACRVIDG 550
Query: 468 ICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFP 527
D GP G G G +C F + TY + +N C
Sbjct: 551 CGSDAGPG-MPGTAASGVCGPHG-RCVSQPGGNFSCICDSGFTGTYCH---ENIDDC--- 602
Query: 528 HEGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEIN 586
+ C NG +C+ E D+ +R C W G + N D + C C D +N
Sbjct: 603 ---LGQPCRNGGTCIDEVDA--FRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVN 656
Score = 134 bits (336), Expect = 3e-31
Identities = 108/450 (24%), Positives = 161/450 (35%), Gaps = 64/450 (14%)
Query: 175 QESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRE 233
+ + +S C+ G C + CHC +SG C ++D C+ PC G+C+++ +
Sbjct: 348 EHACTSNPCANGGSC--HEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVD 405
Query: 234 NWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEV 293
+EC+C + G C + C+ C HG N + C C F G CE+
Sbjct: 406 G-----FECICPEQWVGATCQLDVNDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGGRHCEL 459
Query: 294 SAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISND 353
C S G+C + + + CP+G S E DV PC+NG C + D
Sbjct: 460 ERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGD 519
Query: 354 VMCICSPIFTDLLCKSIQTSCESFPLRNNATCK--------------------KCEK--- 390
C C F C + C R C +C
Sbjct: 520 YYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPG 579
Query: 391 -DYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPG---------- 439
++ C C SGFT C + ID C L C N C + + F+ C G
Sbjct: 580 GNFSCICDSGFTGTYCHENIDDC--LGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNP 637
Query: 440 --CTKNPCWFLKNVY-LIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGV 496
C +PC Y L++ C C + G Q + + S G C
Sbjct: 638 NDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCD-----AYTCSNGGTCYDS 692
Query: 497 IDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCSCLSEEDSQEYRYLCFL 556
D + + +T NSSC P+ C NG +C+ S + +C
Sbjct: 693 GDTFRCACPPGWKGSTCA---VAKNSSC-LPNP-----CVNGGTCVGSGAS--FSCICRD 741
Query: 557 RWAGNMYLENTTDDQENECQHEAVCKDEIN 586
W G NT D C + +C D +N
Sbjct: 742 GWEGRTCTHNTNDCNPLPCYNGGICVDGVN 771
Score = 127 bits (320), Expect = 2e-29
Identities = 105/415 (25%), Positives = 148/415 (35%), Gaps = 65/415 (15%)
Query: 175 QESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRE 233
++ +S C G C E + + CHC FSG C+ ++D C PC+N C N
Sbjct: 461 RDECASSPCHSGGLC--EDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNL-- 516
Query: 234 NWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCF------------------------HGN 269
E Y C C F GKNCS C C HG
Sbjct: 517 ---EGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGR 573
Query: 270 CSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNG 329
C + +F C CD F+G +C + C+ G C + A+ CP G +
Sbjct: 574 CVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELC 633
Query: 330 ETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCE 389
+T+ ++ PC + C + ND C C + C S + C+++ N TC
Sbjct: 634 DTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSG 693
Query: 390 KDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLK 449
+ C+C G+ C A + L C+N C F +C G C
Sbjct: 694 DTFRCACPPGWKGSTCAVA-KNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTC--TH 750
Query: 450 NVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSEG----EKCQGVIDAYFFLAA 505
N + CY G GIC D G F GFAG + ++CQ AY A
Sbjct: 751 NTNDCNPLPCYNG----GICVD-GVNWFRCECAPGFAGPDCRINIDECQSSPCAY---GA 802
Query: 506 NCTED-------------ATYVNDPEDNNSSCW-----FPHEGTKEICANGCSCL 542
C ++ + SCW FPH + N C CL
Sbjct: 803 TCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCL 857
>gi|148886654 polydom [Homo sapiens]
Length = 3571
Score = 134 bits (338), Expect = 2e-31
Identities = 73/234 (31%), Positives = 101/234 (43%), Gaps = 7/234 (2%)
Query: 212 QELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCS 271
Q C F PC N+G+C + Y C+C +TG C I +C P C +
Sbjct: 1192 QVFHECFFNPCHNSGTCQQLG-----RGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVC 1246
Query: 272 NITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGET 331
FICEC ++G CE + C S +GIC + + Y C KG + ET
Sbjct: 1247 KDLVGEFICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCET 1306
Query: 332 DVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKD 391
+V+E PC N C +C C P F C C S P +N ATCK
Sbjct: 1307 EVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANS 1366
Query: 392 YPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPC 445
+ C C +GFT +CE I+ C+ S C N+ C + + + C PG + C
Sbjct: 1367 FRCLCAAGFTGSHCELNINECQ--SNPCRNQATCVDELNSYSCKCQPGFSGKRC 1418
Score = 119 bits (298), Expect = 8e-27
Identities = 67/225 (29%), Positives = 94/225 (41%), Gaps = 8/225 (3%)
Query: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQAYE 241
C G C + + Y C C ++G C+ ++D CS PC NNG C + +
Sbjct: 1202 CHNSGTC--QQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGE-----FI 1254
Query: 242 CVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSL 301
C C +TG+ C E I +C C + + C C + F G CE C S
Sbjct: 1255 CECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSN 1314
Query: 302 LFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPI 361
+C + + +CP G +V E PC+NG C +N C+C+
Sbjct: 1315 PCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAG 1374
Query: 362 FTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCE 406
FT C+ C+S P RN ATC Y C C GF+ K CE
Sbjct: 1375 FTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCE 1419
Score = 96.7 bits (239), Expect = 6e-20
Identities = 54/216 (25%), Positives = 93/216 (43%), Gaps = 11/216 (5%)
Query: 159 CPLGLRLNVTVKQQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQE-LDAC 217
CPLG +K + + S C +G C + C C ++G+ C+E ++ C
Sbjct: 1219 CPLGY---TGLKCETDIDECSPLPCLNNGVCKDLVGE--FICECPSGYTGQRCEENINEC 1273
Query: 218 SFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNS 277
S PC N G C++ Y C C F G +C + +CQ + C +
Sbjct: 1274 SSSPCLNKGICVD-----GVAGYRCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQVGG 1328
Query: 278 FICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFS 337
F+C+C F G C + C+S C + ++++ C G + + E +++E
Sbjct: 1329 FLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQ 1388
Query: 338 LVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTS 373
PC+N C+ N C C P F+ C++ Q++
Sbjct: 1389 SNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQST 1424
Score = 87.0 bits (214), Expect = 5e-17
Identities = 63/259 (24%), Positives = 100/259 (38%), Gaps = 68/259 (26%)
Query: 340 PCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISG 399
PC N C ++ +C+C +T L C++ C P NN CK ++ C C SG
Sbjct: 1201 PCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSG 1260
Query: 400 FTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPG------------CTKNPCWF 447
+T + CE+ I+ C S CLN+ C + + ++ C+ G C NPC
Sbjct: 1261 YTGQRCEENINECS--SSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPC-- 1316
Query: 448 LKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANC 507
L N +C+D+ G KC FL C
Sbjct: 1317 LNNA----------------VCEDQ-------------VGGFLCKCPPG-----FLGTRC 1342
Query: 508 TEDATYVNDPEDNNSSCWFPHEGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENT 567
++ E + C NG +C ++ + +R LC + G+ N
Sbjct: 1343 GKNVD----------------ECLSQPCKNGATC--KDGANSFRCLCAAGFTGSHCELNI 1384
Query: 568 TDDQENECQHEAVCKDEIN 586
+ Q N C+++A C DE+N
Sbjct: 1385 NECQSNPCRNQATCVDELN 1403
Score = 67.4 bits (163), Expect = 4e-11
Identities = 36/112 (32%), Positives = 52/112 (46%), Gaps = 6/112 (5%)
Query: 198 YSCHCQPPFSGKYC-QELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEI 256
+ C C P F G C + +D C +PCKN +C + ++ C+C FTG +C
Sbjct: 1329 FLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKD-----GANSFRCLCAAGFTGSHCELN 1383
Query: 257 IGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGI 308
I +CQ + C + NS+ C+C FSG CE +L F GI
Sbjct: 1384 INECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQSTGFNLDFEVSGI 1435
Score = 47.0 bits (110), Expect = 5e-05
Identities = 50/189 (26%), Positives = 72/189 (38%), Gaps = 33/189 (17%)
Query: 230 NKRENWDEQAYECV---CHPPFTGKNCSEI-----IGQCQPHVCFHGNCSNITSNSFICE 281
N E W + + +C C PP +N G + C+ G S E
Sbjct: 3399 NPDETWTQTSAKCEKISCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLE 3458
Query: 282 CDEQFSGPFCEVSAK-PCVSLLFWKRGIC--PNSSSAYTYECPKGSSSQNGETDVSEFSL 338
S P C + PC + GIC PN+ S CP+G + E + +
Sbjct: 3459 NGTWTSPPICRAVCRFPCQN-----GGICQRPNACS-----CPEGWMGRLCEEPIC---I 3505
Query: 339 VPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCIS 398
+PC NG C+ C C P +T C + C+S P N KC + C C+S
Sbjct: 3506 LPCLNGGRCVA---PYQCDCPPGWTGSRCHT--AVCQS-PCLNGG---KCVRPNRCHCLS 3556
Query: 399 GFTEKNCEK 407
+T NC +
Sbjct: 3557 SWTGHNCSR 3565
Score = 43.5 bits (101), Expect = 6e-04
Identities = 24/83 (28%), Positives = 34/83 (40%), Gaps = 15/83 (18%)
Query: 172 QFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINK 231
+ C+E + C G+C++ Y C C P ++G C A PC N G C+
Sbjct: 3497 RLCEEPICILPCLNGGRCVAP-----YQCDCPPGWTGSRCH--TAVCQSPCLNGGKCVRP 3549
Query: 232 RENWDEQAYECVCHPPFTGKNCS 254
C C +TG NCS
Sbjct: 3550 N--------RCHCLSSWTGHNCS 3564
Score = 37.0 bits (84), Expect = 0.054
Identities = 19/50 (38%), Positives = 28/50 (56%), Gaps = 8/50 (16%)
Query: 211 CQELDACSF-KPCKNNGSCINKRENWDEQAYECVCHPPFT--GKNCSEII 257
C ++D C+ C + SC+N + +Y C C PP+T GKNC+E I
Sbjct: 1743 CLDVDECAVGSDCSEHASCLNV-----DGSYICSCVPPYTGDGKNCAEPI 1787
Score = 35.0 bits (79), Expect = 0.20
Identities = 15/37 (40%), Positives = 19/37 (51%), Gaps = 2/37 (5%)
Query: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSF 219
C C+ E +YSC CQP FSGK C+ + F
Sbjct: 1392 CRNQATCVDEL--NSYSCKCQPGFSGKRCETEQSTGF 1426
Score = 31.6 bits (70), Expect = 2.3
Identities = 18/46 (39%), Positives = 21/46 (45%), Gaps = 4/46 (8%)
Query: 183 CSGHGKCLSEAWSKTYSCHCQPPFS--GKYCQELDACSFKPCKNNG 226
CS H CL+ S Y C C PP++ GK C E C NG
Sbjct: 1755 CSEHASCLNVDGS--YICSCVPPYTGDGKNCAEPIKCKAPGNPENG 1798
Score = 31.6 bits (70), Expect = 2.3
Identities = 25/86 (29%), Positives = 33/86 (38%), Gaps = 14/86 (16%)
Query: 340 PCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISG 399
PCQNG C + + C C + LC+ + C P N +C Y C C G
Sbjct: 3475 PCQNGGICQRPN---ACSCPEGWMGRLCE--EPIC-ILPCLNGG---RCVAPYQCDCPPG 3525
Query: 400 FTEKNCEKAIDHCKLLSINCLNEEWC 425
+T C H + CLN C
Sbjct: 3526 WTGSRC-----HTAVCQSPCLNGGKC 3546
>gi|55770876 notch4 preproprotein [Homo sapiens]
Length = 2003
Score = 133 bits (335), Expect = 4e-31
Identities = 125/490 (25%), Positives = 183/490 (37%), Gaps = 75/490 (15%)
Query: 157 SPCPLGLRLNVTVKQQF----CQESLSS----EFCSGHGKCLSEAWSKTYSCHCQPPFSG 208
SP PL T F CQ L FCS G+C +A + C C P ++G
Sbjct: 93 SPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRP-QCSCMPGWTG 151
Query: 209 KYCQELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQC--QPHVCF 266
+ CQ D CS PC N G C+ +C C P F G C + +C P C
Sbjct: 152 EQCQLRDFCSANPCVNGGVCLATYPQ-----IQCHCPPGFEGHACERDVNECFQDPGPCP 206
Query: 267 HGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGIC----PNSSSAYTYECPK 322
G + T SF C C GP CE+ A PC G C S+ + CP
Sbjct: 207 KGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPP 266
Query: 323 GSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESF---PL 379
G + E + CQNG C + C+C +T C CE+
Sbjct: 267 GFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGPPHC 326
Query: 380 RNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPG 439
RN TC+ + C C+SG+ +CE+ +D C ++ C C + +G F +C PG
Sbjct: 327 RNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDC--IAATCAPGSTCIDRVGSFSCLCPPG 384
Query: 440 -----------CTKNPCW---FLKNVYLIHQHLCYC-----GVTFH-------------G 467
C PC L LC C G T H
Sbjct: 385 RTGLLCHLEDMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPS 444
Query: 468 ICQDKG-----PAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNS 522
C+ G P F + G+ GS +C+ D L+ C +T ++ +
Sbjct: 445 PCEHGGSCLNTPGSFNCLCPPGYTGS---RCEA--DHNECLSQPCHPGSTCLDLLATFHC 499
Query: 523 SCWFPHEGTK-EICANGCS---CLSEEDSQE----YRYLCFLRWAGNMYLENTTDDQENE 574
C EG E+ N C+ CL+ D + ++ +C ++G E+ + + +
Sbjct: 500 LCPPGLEGQLCEVETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSP 559
Query: 575 CQHEAVCKDE 584
C + C+D+
Sbjct: 560 CANGGQCQDQ 569
Score = 132 bits (331), Expect = 1e-30
Identities = 106/410 (25%), Positives = 156/410 (38%), Gaps = 59/410 (14%)
Query: 174 CQESLS---SEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCIN 230
C+E+L + C+ C+ S +SC C P +G C D C +PC + C
Sbjct: 352 CEENLDDCIAATCAPGSTCIDRVGS--FSCLCPPGRTGLLCHLEDMCLSQPCHGDAQCST 409
Query: 231 KRENWDEQAYECVCHPPFTGKNCSEIIGQCQ-----PHVCFHGNCSNITSNSFICECDEQ 285
N + C+C P ++G C + + +C P C HG T SF C C
Sbjct: 410 ---NPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPG 466
Query: 286 FSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGT 345
++G CE C+S C + + + CP G Q E + +E + PC N
Sbjct: 467 YTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNECASAPCLNHA 526
Query: 346 DCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNC 405
DC + N CIC P F+ C+ C S P N C+ + C C+ GF C
Sbjct: 527 DCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRC 586
Query: 406 EKAIDHCKLLSINCLNEEWCFNIIGRFKYVC----------IPGCTKNPC---WFLKNVY 452
+ +D C LS C C ++ G F +C +P C N C K+
Sbjct: 587 QTEVDEC--LSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQK 644
Query: 453 LIHQHLCYCG-----------VTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYF 501
LC G HG CQ + V +G+ G E C+ +
Sbjct: 645 DKANCLCPDGSPGCAPPEDNCTCHHGHCQ-----RSSCVCDVGWTGPE---CEAELGG-- 694
Query: 502 FLAANCTEDATYVNDPEDNNSSCWFPHEG---TKEI-------CANGCSC 541
++A C T P N +C + G ++E+ C NG SC
Sbjct: 695 CISAPCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSGPCLNGGSC 744
Score = 129 bits (323), Expect = 1e-29
Identities = 87/335 (25%), Positives = 132/335 (39%), Gaps = 29/335 (8%)
Query: 174 CQESLS---SEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQEL--DACSFKPCKNNGSC 228
CQ S S C G C++ T+SC C F G C+ +C+ PC+N +C
Sbjct: 764 CQTSTDYCVSAPCFNGGTCVNRPG--TFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATC 821
Query: 229 INKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSG 288
+ Q C+C +TG +C ++ C C + T SF C C + ++G
Sbjct: 822 QDS-----PQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTG 876
Query: 289 PFCEVSAKPC----------VSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSL 338
P C + C VS L G+C +S +Y CP G + V+
Sbjct: 877 PLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGSLCQDHVNPCES 936
Query: 339 VPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCIS 398
PCQNG C+ + +C C+P + C +C+S P N+ TC + C+C
Sbjct: 937 RPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPP 996
Query: 399 GFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHL 458
GF CE +D C + C ++ F C+PG T W + H
Sbjct: 997 GFVGLRCEGDVDECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQ--WCEVEIDPCHSQP 1054
Query: 459 CYCGVTFHGICQDKGPAQFEYVWQLGFAGSEGEKC 493
C+ G G C+ + ++ G EG C
Sbjct: 1055 CFHG----GTCEATAGSPLGFICHCP-KGFEGPTC 1084
Score = 111 bits (278), Expect = 2e-24
Identities = 85/336 (25%), Positives = 120/336 (35%), Gaps = 53/336 (15%)
Query: 174 CQESLS---SEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCI 229
C+E + S C+ G+C + + + C C P F G CQ E+D C PC SC+
Sbjct: 548 CEEDIDECRSSPCANGGQCQDQPGA--FHCKCLPGFEGPRCQTEVDECLSDPCPVGASCL 605
Query: 230 NKRENWDEQAYECVCHPPFTGKNCSEII---GQCQPH----------------------- 263
+ A+ C+C FTG+ C + CQP
Sbjct: 606 DL-----PGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPGCAP 660
Query: 264 -----VCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTY 318
C HG+C + C CD ++GP CE C+S G C S Y
Sbjct: 661 PEDNCTCHHGHCQRSS-----CVCDVGWTGPECEAELGGCISAPCAHGGTCYPQPSGYNC 715
Query: 319 ECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFP 378
CP G + +++ PC NG C C C P T C++ C S P
Sbjct: 716 TCPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAP 775
Query: 379 LRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIP 438
N TC + C C GF CE + C N C + + +C
Sbjct: 776 CFNGGTCVNRPGTFSCLCAMGFQGPRCEGKL-RPSCADSPCRNRATCQDSPQGPRCLCPT 834
Query: 439 GCTKNPCWFLKNVYL-----IHQHLCYCGVTFHGIC 469
G T C L ++ + H G +FH +C
Sbjct: 835 GYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLC 870
Score = 101 bits (251), Expect = 2e-21
Identities = 100/413 (24%), Positives = 143/413 (34%), Gaps = 75/413 (18%)
Query: 156 PSPCPLGLRLNVTVKQQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-EL 214
P PCP G C +L S + C C G C+
Sbjct: 202 PGPCPKGTS---------CHNTLGS-----------------FQCLCPVGQEGPRCELRA 235
Query: 215 DACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNIT 274
C + C N G+C E D + C+C P F G +C C H C +G
Sbjct: 236 GPCPPRGCSNGGTCQLMPEK-DSTFHLCLCPPGFIGPDCEVNPDNCVSHQCQNGGTCQDG 294
Query: 275 SNSFICECDEQFSGPFCEVSAKPCVSL---LFWKRGICPNSSSAYTYECPKGSSSQNGET 331
+++ C C E ++G C C + G C NS+ ++ C G + E
Sbjct: 295 LDTYTCLCPETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEE 354
Query: 332 DVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATC--KKCE 389
++ + C G+ CI C+C P T LLC ++ C S P +A C
Sbjct: 355 NLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLC-HLEDMCLSQPCHGDAQCSTNPLT 413
Query: 390 KDYPCSCISGFTEKNCEKAIDHCKLLSIN---CLNEEWCFNIIGRFKYVCIPGCTKNPCW 446
C C G++ C + +D C + C + C N G F +C PG T + C
Sbjct: 414 GSTLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCE 473
Query: 447 FLKNVYLIHQHLCYCG-------VTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDA 499
N L C+ G TFH +C G EG+ C+
Sbjct: 474 ADHNECL--SQPCHPGSTCLDLLATFHCLCP---------------PGLEGQLCE----- 511
Query: 500 YFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCS-CLSEEDSQEYR 551
E + P N++ C G + IC G S EED E R
Sbjct: 512 --------VETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECR 556
Score = 100 bits (249), Expect = 4e-21
Identities = 103/391 (26%), Positives = 153/391 (39%), Gaps = 51/391 (13%)
Query: 181 EFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDAC-SFKPCKNNGSC---------IN 230
E C+ G CLS + + +C C P F G+ CQ D C + + C+N GSC +
Sbjct: 33 EPCANGGTCLSLSLGQG-TCQCAPGFLGETCQFPDPCQNAQLCQNGGSCQALLPAPLGLP 91
Query: 231 KRENWDEQAYECVCHPPFTGKNC-SEIIGQCQPHVCF-HGNCSNITSNSFICECDEQFSG 288
+ ++ C C P FTG+ C +++ C P C G C S C C ++G
Sbjct: 92 SSPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTG 151
Query: 289 PFCEV----SAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEF--SLVPCQ 342
C++ SA PCV+ G+C + CP G E DV+E PC
Sbjct: 152 EQCQLRDFCSANPCVN-----GGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCP 206
Query: 343 NGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKC-EKD---YPCSCIS 398
GT C C+C C+ C N TC+ EKD + C C
Sbjct: 207 KGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPP 266
Query: 399 GFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHL 458
GF +CE D+C +S C N C + + + +C T C + +
Sbjct: 267 GFIGPDCEVNPDNC--VSHQCQNGGTCQDGLDTYTCLCPETWTGWDC---------SEDV 315
Query: 459 CYCGVTFHGICQDKGPAQ-----FEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATY 513
C C++ G Q F V G+ G+ C+ +D +AA C +T
Sbjct: 316 DECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGT---SCEENLDD--CIAATCAPGSTC 370
Query: 514 VNDPEDNNSSCWFPHEGTKEICANGCSCLSE 544
++ + SC P T +C CLS+
Sbjct: 371 ID--RVGSFSCLCPPGRTGLLCHLEDMCLSQ 399
Score = 77.0 bits (188), Expect = 5e-14
Identities = 60/213 (28%), Positives = 83/213 (38%), Gaps = 54/213 (25%)
Query: 154 SGPS---PCPLGLRLNVTVKQQFCQESLS---SEFCSGHGKCLSEAWSKTYSCHCQPPFS 207
SGPS CP G + ++ CQ+ ++ S C C+++ Y C C P +
Sbjct: 910 SGPSYFCHCPPGFQGSL------CQDHVNPCESRPCQNGATCMAQP--SGYLCQCAPGYD 961
Query: 208 GKYC-QELDACSFKPCKNNGSCINKRENW-----------------DE------------ 237
G+ C +ELDAC +PC N+G+C K + DE
Sbjct: 962 GQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTA 1021
Query: 238 ------QAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNS---FICECDEQFSG 288
A+ C C P TG+ C I C CFHG T+ S FIC C + F G
Sbjct: 1022 ACHSLANAFYCQCLPGHTGQWCEVEIDPCHSQPCFHGGTCEATAGSPLGFICHCPKGFEG 1081
Query: 289 PFCEVSAKPCVSLLFWKRGIC-PNSSSAYTYEC 320
P C A C G+C P+ + C
Sbjct: 1082 PTCSHRAPSCGFHHCHHGGLCLPSPKPGFPPRC 1114
Score = 50.8 bits (120), Expect = 4e-06
Identities = 65/277 (23%), Positives = 102/277 (36%), Gaps = 44/277 (15%)
Query: 340 PCQNGTDCIKIS-NDVMCICSPIFTDLLCKSIQTSCESFPL-RNNATCKKC--------- 388
PC NG C+ +S C C+P F C+ C++ L +N +C+
Sbjct: 34 PCANGGTCLSLSLGQGTCQCAPGFLGETCQ-FPDPCQNAQLCQNGGSCQALLPAPLGLPS 92
Query: 389 -----EKDYPCSCISGFTEKNCE-KAIDHCKLLSINCLNEEWC-FNIIGRFKYVCIPGCT 441
+ C+C+ GFT + C+ K D C C C GR + C+PG T
Sbjct: 93 SPSPLTPSFLCTCLPGFTGERCQAKLEDPCP--PSFCSKRGRCHIQASGRPQCSCMPGWT 150
Query: 442 KNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYF 501
C + C G G+C P Q + GF EG C+ ++ F
Sbjct: 151 GEQCQLRD---FCSANPCVNG----GVCLATYP-QIQCHCPPGF---EGHACERDVNECF 199
Query: 502 FLAANCTEDATYVNDPEDNNSSCWFPHEGTK----------EICANG--CSCLSEEDSQE 549
C + + N C EG + C+NG C + E+DS
Sbjct: 200 QDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTF 259
Query: 550 YRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEIN 586
+ LC + G N + ++CQ+ C+D ++
Sbjct: 260 HLCLCPPGFIGPDCEVNPDNCVSHQCQNGGTCQDGLD 296
>gi|134244285 Notch homolog 3 [Homo sapiens]
Length = 2321
Score = 130 bits (327), Expect = 4e-30
Identities = 116/425 (27%), Positives = 166/425 (39%), Gaps = 41/425 (9%)
Query: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYEC 242
C+ G+C ++ S+ +C C P + G+ CQ D C PC G C + + + C
Sbjct: 49 CANGGRC-TQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTAR-FSC 106
Query: 243 VCHPPFTGKNCSEIIGQCQPHVCFHG-NCSNITSNSFICECDEQFSGPFCEVSAKPC-VS 300
C F G +CS + C C HG CS F+C C + G C C V
Sbjct: 107 RCPRGFRGPDCS-LPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVG 165
Query: 301 LLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVM--CIC 358
G C N+ ++ +CP G + E + PC+NG C + S D+ C C
Sbjct: 166 EPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTC-RQSGDLTYDCAC 224
Query: 359 SPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSIN 418
P F C+ C N TC Y C C +T + C + +D C+L
Sbjct: 225 LPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNA 284
Query: 419 CLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHG-ICQDKGPAQF 477
C N CFN +G VC+ G T C +N+ C V FHG C D+ A F
Sbjct: 285 CHNGGTCFNTLGGHSCVCVNGWTGESC--SQNI-----DDCATAVCFHGATCHDR-VASF 336
Query: 478 EYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEIC-- 535
+ G G C + DA ++ C EDA +P + + C P T C
Sbjct: 337 YCACPM---GKTGLLCH-LDDA--CVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQ 390
Query: 536 --------ANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENE-----CQHEAVCK 582
AN C L + + +LC G Y + NE C+++A C
Sbjct: 391 DVDECSIGANPCEHLGRCVNTQGSFLC---QCGRGYTGPRCETDVNECLSGPCRNQATCL 447
Query: 583 DEINR 587
D I +
Sbjct: 448 DRIGQ 452
Score = 129 bits (325), Expect = 6e-30
Identities = 111/436 (25%), Positives = 165/436 (37%), Gaps = 66/436 (15%)
Query: 197 TYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEI 256
++ C C +G C DAC PC + C N C C P FTG C +
Sbjct: 335 SFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAI---CTCPPGFTGGACDQD 391
Query: 257 IGQCQ--PHVCFH-GNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSS 313
+ +C + C H G C N T SF+C+C ++GP CE C+S + C +
Sbjct: 392 VDECSIGANPCEHLGRCVN-TQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRI 450
Query: 314 SAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTS 373
+T C G + E D+ E PC NG C N C C F+ C+
Sbjct: 451 GQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDE 510
Query: 374 CESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFK 433
C S P RN A C Y C C GF C++ +D C S + + C + I F
Sbjct: 511 CASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDC---SPDPCHHGRCVDGIASFS 567
Query: 434 YVCIPG------------CTKNPCWF-LKNVYLIHQHLCYC--GVT-------------- 464
C PG C PC K + L+ ++LC C G T
Sbjct: 568 CACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASN 627
Query: 465 --FHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNS 522
G+C+D G +++ V Q GF G C ++ ++ C E + V+ +N
Sbjct: 628 PCTFGVCRD-GINRYDCVCQPGFT---GPLCN--VEINECASSPCGEGGSCVDG--ENGF 679
Query: 523 SCWFP------------HEGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDD 570
C P H E C++G + + +R +C W+G ++ D
Sbjct: 680 RCLCPPGSLPPLCLPPSHPCAHEPCSHG---ICYDAPGGFRCVCEPGWSGPRCSQSLARD 736
Query: 571 --QENECQHEAVCKDE 584
+ C+ C +
Sbjct: 737 ACESQPCRAGGTCSSD 752
Score = 128 bits (321), Expect = 2e-29
Identities = 106/431 (24%), Positives = 160/431 (37%), Gaps = 62/431 (14%)
Query: 171 QQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCIN 230
Q +++ S+ C G C S+ + C C P G+ C+ L C+ PC++ G C +
Sbjct: 731 QSLARDACESQPCRAGGTCSSDGMG--FHCTCPPGVQGRQCELLSPCTPNPCEHGGRCES 788
Query: 231 K------------------RENWDEQA-----------------YECVCHPPFTGKNCSE 255
+++ DE A + C CH +TG +C +
Sbjct: 789 APGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQ 848
Query: 256 IIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSA 315
I C P+ C +G SF C C F+GP C C+S G C + ++
Sbjct: 849 DINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGP-GTCTDHVAS 907
Query: 316 YTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCE 375
+T CP G + E D+ + S C NG C+ N C+C P +T C+ C
Sbjct: 908 FTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCL 967
Query: 376 SFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYV 435
S P + C + C+C+ FT C+ +D C C N C G + +
Sbjct: 968 SRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQP--CQNGGRCVQ-TGAY-CL 1023
Query: 436 CIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFE--YVWQLGFAGSEGEKC 493
C PG + C + GV +CQ G E + + G G C
Sbjct: 1024 CPPGWSGRLCDI--RSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHC 1081
Query: 494 QGVIDAYFFLAANCTEDAT---YVND------PEDNNSSCWFP-HEGTKEICANGCSCLS 543
+ +D LA C T Y+ P N +C E + C +G SC+
Sbjct: 1082 EQEVDP--CLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCI- 1138
Query: 544 EEDSQEYRYLC 554
RYLC
Sbjct: 1139 ---DLVARYLC 1146
Score = 120 bits (302), Expect = 3e-27
Identities = 89/346 (25%), Positives = 143/346 (41%), Gaps = 50/346 (14%)
Query: 154 SGPSPC-PLGLRLNVT----------VKQQFCQESLSS---EFCSGHGKCLSEAWSKTYS 199
+GP+PC P G+ N+ C + ++ C G C S +S
Sbjct: 815 AGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGS--FS 872
Query: 200 CHCQPPFSGKYC-QELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIG 258
C C P F+G C +++D C PC G+C + ++ C C P + G +C + +
Sbjct: 873 CSCLPGFAGPRCARDVDECLSNPC-GPGTCTDH-----VASFTCTCPPGYGGFHCEQDLP 926
Query: 259 QCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTY 318
C P CF+G NSF C C ++G C+ A PC+S G+C + +
Sbjct: 927 DCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRC 986
Query: 319 ECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCE--- 375
C + + +T V S PCQNG C++ C+C P ++ LC C
Sbjct: 987 TCLESFTGPQCQTLVDWCSRQPCQNGGRCVQ--TGAYCLCPPGWSGRLCDIRSLPCREAA 1044
Query: 376 -SFPLRNNATCK---KC---EKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNI 428
+R C+ +C + + C C G T +CE+ +D C L+ C + C
Sbjct: 1045 AQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPC--LAQPCQHGGTCRGY 1102
Query: 429 IGRFKYVCIPG------------CTKNPCWFLKN-VYLIHQHLCYC 461
+G + C+PG C PC + + L+ ++LC C
Sbjct: 1103 MGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSC 1148
Score = 114 bits (284), Expect = 3e-25
Identities = 80/279 (28%), Positives = 116/279 (41%), Gaps = 27/279 (9%)
Query: 186 HGKCLSEAWSKTYSCHCQPPFSGKYCQEL-DACSFKPCKNNGSCINKRENWDEQAYECVC 244
HG S A + C C F+G CQ L D CS +PC+N G C+ AY C+C
Sbjct: 973 HGGVCSAA-HPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTG------AY-CLC 1024
Query: 245 HPPFTGKNC----------SEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVS 294
P ++G+ C + IG +C G +S C C E +G CE
Sbjct: 1025 PPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQE 1084
Query: 295 AKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDV 354
PC++ G C Y EC G + N E DV E + PCQ+G CI +
Sbjct: 1085 VDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARY 1144
Query: 355 MCICSPIFTDLLCKSIQTSCESFP-------LRNNATCKKCEKDYPCSCISGFTEKNCEK 407
+C C P +LC+ + C P +N TC + C+C G+T CE
Sbjct: 1145 LCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEA 1204
Query: 408 AIDHCKLLSINCLNEEWCF-NIIGRFKYVCIPGCTKNPC 445
I+ C+ + + + C + G F+ +C G + C
Sbjct: 1205 DINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRC 1243
Score = 70.1 bits (170), Expect = 6e-12
Identities = 54/242 (22%), Positives = 86/242 (35%), Gaps = 62/242 (25%)
Query: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCK--NNGSCINKRENWDEQA 239
C +G C+ + C C P ++G C+ +++ C C + C+
Sbjct: 1176 CLHNGTCVDLVGG--FRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGG----G 1229
Query: 240 YECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSN-----SFICECDEQFSGPFCEVS 294
+ C+CH F+G C ++ C+ C HG + +F C C + F GP CE
Sbjct: 1230 FRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERV 1289
Query: 295 AKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDV 354
A+ C L +CP G VPCQ +
Sbjct: 1290 ARSCREL-----------------QCPVG---------------VPCQ------QTPRGP 1311
Query: 355 MCICSPIFTDLLCKSI--------QTSCESFPLRNNATCKKC--EKDYPCSCISGFTEKN 404
C C P + C+S SC + P + +C+ + C+C G+T
Sbjct: 1312 RCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPR 1371
Query: 405 CE 406
CE
Sbjct: 1372 CE 1373
>gi|41327708 crumbs homolog 1 precursor [Homo sapiens]
Length = 1406
Score = 128 bits (322), Expect = 1e-29
Identities = 106/432 (24%), Positives = 167/432 (38%), Gaps = 40/432 (9%)
Query: 161 LGLRLNVTVKQQFCQESLS---SEFCSGHGKCLSEAWSKTYSCHCQPPFSG--KYCQEL- 214
L L + +K FC ++ + S C + C + +SK C C + K C +
Sbjct: 14 LSFSLLIYIKNSFCNKNNTRCLSNSCQNNSTC--KDFSKDNDCSCSDTANNLDKDCDNMK 71
Query: 215 DACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNIT 274
D C PC+ + +C+N E+++ C C P ++G C IG C + C HG +
Sbjct: 72 DPCFSNPCQGSATCVNTP---GERSFLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQD 128
Query: 275 SNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVS 334
+C C ++G FCE+ C S +C + Y+ C G ++ + +V
Sbjct: 129 PIYPVCICPAGYAGRFCEIDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVD 188
Query: 335 EFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPC 394
E + PC+N C+ CIC ++ + C+ C S P N ATC+ Y C
Sbjct: 189 ECASDPCKNEATCLNEIGRYTCICPHNYSGVNCELEIDECWSQPCLNGATCQDALGAYFC 248
Query: 395 SCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCI-PGCTKNPCWFLKNVYL 453
C GF +CE D C S CL+ C + R+ C G T C L + L
Sbjct: 249 DCAPGFLGDHCELNTDEC--ASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETL--MPL 304
Query: 454 IHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATY 513
C+ T C+D + W G+ G A C D
Sbjct: 305 CWSKPCHNNAT----CEDSVDNYTCHCWP-GYTG-----------------AQCEIDLNE 342
Query: 514 VN-DPEDNNSSCWFPHEGTKEICANGC-SCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQ 571
N +P +N C + G S S ++ Y +C + G E+ +
Sbjct: 343 CNSNPCQSNGECVELSSEKQYGRITGLPSSFSYHEASGYVCICQPGFTGIHCEEDVNECS 402
Query: 572 ENECQHEAVCKD 583
N CQ+ C++
Sbjct: 403 SNPCQNGGTCEN 414
Score = 119 bits (299), Expect = 6e-27
Identities = 94/390 (24%), Positives = 141/390 (36%), Gaps = 87/390 (22%)
Query: 174 CQESLSSEFCS-GHGKCLSEAWSKT---------YSCHCQPPFSGKYCQ-ELDACSFKPC 222
C + FC H +C S YSC C P + G++C E+D C+ PC
Sbjct: 136 CPAGYAGRFCEIDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASDPC 195
Query: 223 KNNGSCINK---------------------RENWDEQ------------AYECVCHPPFT 249
KN +C+N+ E W + AY C C P F
Sbjct: 196 KNEATCLNEIGRYTCICPHNYSGVNCELEIDECWSQPCLNGATCQDALGAYFCDCAPGFL 255
Query: 250 GKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQ-FSGPFCEVSAKPCVSLLFWKRGI 308
G +C +C C HG N + C C F+G CE C S
Sbjct: 256 GDHCELNTDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCWSKPCHNNAT 315
Query: 309 CPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISND--------------- 353
C +S YT C G + E D++E + PCQ+ +C+++S++
Sbjct: 316 CEDSVDNYTCHCWPGYTGAQCEIDLNECNSNPCQSNGECVELSSEKQYGRITGLPSSFSY 375
Query: 354 -----VMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKA 408
+CIC P FT + C+ C S P +N TC+ +Y C C +
Sbjct: 376 HEASGYVCICQPGFTGIHCEEDVNECSSNPCQNGGTCENLPGNYTCHCPFDNLSRTFYGG 435
Query: 409 IDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHG- 467
D C + + C +++ C N CIP H C C + G
Sbjct: 436 RD-CSDILLGCTHQQ-CLN-----NGTCIPHFQDGQ----------HGFSCLCPSGYTGS 478
Query: 468 ICQDKGPAQFE---YVW-QLGFAGSEGEKC 493
+C+ FE ++W + G ++G C
Sbjct: 479 LCEIATTLSFEGDGFLWVKSGSVTTKGSVC 508
Score = 104 bits (260), Expect = 2e-22
Identities = 65/229 (28%), Positives = 91/229 (39%), Gaps = 40/229 (17%)
Query: 179 SSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDE 237
+S C G C E +Y C C +SGK+C+ +D C PC + G+C ++
Sbjct: 1144 NSNPCLHGGNC--EDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIH-GNCSDR-----V 1195
Query: 238 QAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKP 297
AY C C P +TG NC I CQ H C +G +N + C C F+G FC S P
Sbjct: 1196 AAYHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLP 1255
Query: 298 CVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCI 357
+C N + T C NG +C + ++ C+
Sbjct: 1256 ST--------VCGNEKTNLT-----------------------CYNGGNCTEFQTELKCM 1284
Query: 358 CSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCE 406
C P FT C+ C S P N C+ + C C F + CE
Sbjct: 1285 CRPGFTGEWCEKDIDECASDPCVNGGLCQDLLNKFQCLCDVAFAGERCE 1333
Score = 94.0 bits (232), Expect = 4e-19
Identities = 58/190 (30%), Positives = 86/190 (45%), Gaps = 22/190 (11%)
Query: 260 CQPHVCFH-GNCSNITSNSFICECDEQFSGPFCEVS-----AKPCVSLLFWKRGICPNSS 313
C + C H GNC +I S S+ C C +SG CE++ + PC+ G C +
Sbjct: 1143 CNSNPCLHGGNCEDIYS-SYHCSCPLGWSGKHCELNIDECFSNPCI------HGNCSDRV 1195
Query: 314 SAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQ-- 371
+AY C G + N E D+ C NG CI +N C+C FT C+ +
Sbjct: 1196 AAYHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLP 1255
Query: 372 -TSC----ESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCF 426
T C + N C + + + C C GFT + CEK ID C S C+N C
Sbjct: 1256 STVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDEC--ASDPCVNGGLCQ 1313
Query: 427 NIIGRFKYVC 436
+++ +F+ +C
Sbjct: 1314 DLLNKFQCLC 1323
Score = 71.6 bits (174), Expect = 2e-12
Identities = 54/193 (27%), Positives = 83/193 (43%), Gaps = 16/193 (8%)
Query: 307 GICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLL 366
G C + S+Y CP G S ++ E ++ E PC +G +C C C P +T +
Sbjct: 1152 GNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHG-NCSDRVAAYHCTCEPGYTGVN 1210
Query: 367 CKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKA-----IDHCKLLSINCLN 421
C+ +C+S N ATC Y C C FT K C ++ + + ++ C N
Sbjct: 1211 CEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPSTVCGNEKTNLTCYN 1270
Query: 422 EEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYVW 481
C K +C PG T W K++ C G G+CQD +F+ +
Sbjct: 1271 GGNCTEFQTELKCMCRPGFTGE--WCEKDIDECASDPCVNG----GLCQDL-LNKFQCLC 1323
Query: 482 QLGFAGSEGEKCQ 494
+ FA GE+C+
Sbjct: 1324 DVAFA---GERCE 1333
Score = 69.3 bits (168), Expect = 1e-11
Identities = 74/299 (24%), Positives = 121/299 (40%), Gaps = 55/299 (18%)
Query: 59 FLGVNTKIDTSGNQAVPQICPLQ-----IQLGDILVISSEPSLQF----PEINLMNVSET 109
FL NT I G++A+ I LQ I++G I + E F E + +S
Sbjct: 1073 FLKDNTDIYV-GDRAIDNIKGLQGCLSTIEIGGIYLSYFENVHGFINKPQEEQFLKISTN 1131
Query: 110 SFV-GCVQ-NTTTEDQLLFGCRLKGMHTVNSKWLSVGTHYFITVMASGPSPCPLGLRLNV 167
S V GC+Q N + L G + +++ S CPLG
Sbjct: 1132 SVVTGCLQLNVCNSNPCLHGGNCEDIYS------------------SYHCSCPLGW---- 1169
Query: 168 TVKQQFCQESLSSEFCSG--HGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKN 224
+ C+ ++ F + HG C Y C C+P ++G C+ ++D C C N
Sbjct: 1170 --SGKHCELNIDECFSNPCIHGNCSDRV--AAYHCTCEPGYTGVNCEVDIDNCQSHQCAN 1225
Query: 225 NGSCINKRENWDEQAYECVCHPPFTGKNC------SEIIGQCQPHV-CFHG-NCSNITSN 276
+CI+ Y C+C FTGK C S + G + ++ C++G NC+ +
Sbjct: 1226 GATCISHTNG-----YSCLCFGNFTGKFCRQSRLPSTVCGNEKTNLTCYNGGNCTEFQTE 1280
Query: 277 SFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSE 335
C C F+G +CE C S G+C + + + C + + E D+++
Sbjct: 1281 -LKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLLNKFQCLCDVAFAGERCEVDLAD 1338
Score = 48.5 bits (114), Expect = 2e-05
Identities = 47/174 (27%), Positives = 67/174 (38%), Gaps = 40/174 (22%)
Query: 81 QIQLGDILVISSEPSLQFPEINLMNVSETSFVGCVQNTTTEDQLLFGCRLKGMHTVNSKW 140
+I+ GD++ I P Q E+N F GC+Q+ +Q L
Sbjct: 823 KIEKGDVIYIGGLPDKQETELN-----GGFFKGCIQDVRLNNQNL--------------- 862
Query: 141 LSVGTHYFITVMASGPSPCPLGLRLNVTVKQQFC--QESLSSEFCSGHGKCLSEAWSKTY 198
F + S P+ +NVT Q C S S C G C S W +
Sbjct: 863 ------EFFPNPTNNASLNPV--LVNVT---QGCAGDNSCKSNPCHNGGVCHSR-WDD-F 909
Query: 199 SCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKN 252
SC C SGK C+E+ C F PC + C Q +EC+ + F G++
Sbjct: 910 SCSCPALTSGKACEEVQWCGFSPCPHGAQCQPVL-----QGFECIANAVFNGQS 958
Score = 44.3 bits (103), Expect = 3e-04
Identities = 48/214 (22%), Positives = 78/214 (36%), Gaps = 38/214 (17%)
Query: 374 CESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFK 433
C S P + C+ Y CSC G++ K+CE ID C S C++ C + + +
Sbjct: 1143 CNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDEC--FSNPCIHGN-CSDRVAAYH 1199
Query: 434 YVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSEGEKC 493
C PG T C ++ H C G T I G + L F G+ C
Sbjct: 1200 CTCEPGYTGVNCEV--DIDNCQSHQCANGATC--ISHTNGYS------CLCFGNFTGKFC 1249
Query: 494 QGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCSCLSEEDSQEYRYL 553
+ + S +E T C NG +C E E + +
Sbjct: 1250 R-----------------------QSRLPSTVCGNEKTNLTCYNGGNC--TEFQTELKCM 1284
Query: 554 CFLRWAGNMYLENTTDDQENECQHEAVCKDEINR 587
C + G ++ + + C + +C+D +N+
Sbjct: 1285 CRPGFTGEWCEKDIDECASDPCVNGGLCQDLLNK 1318
Score = 42.4 bits (98), Expect = 0.001
Identities = 18/43 (41%), Positives = 24/43 (55%), Gaps = 5/43 (11%)
Query: 211 CQELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNC 253
C D C +PC++ G CIN W +Y+C CH P+ G NC
Sbjct: 670 CVRKDWCESQPCQSRGRCINL---W--LSYQCDCHRPYEGPNC 707
Score = 38.1 bits (87), Expect = 0.024
Identities = 23/78 (29%), Positives = 31/78 (39%), Gaps = 6/78 (7%)
Query: 211 CQELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNC 270
C ++C PC N G C WD+ + C C +GK C E + C C HG
Sbjct: 885 CAGDNSCKSNPCHNGGVC---HSRWDD--FSCSCPALTSGKACEE-VQWCGFSPCPHGAQ 938
Query: 271 SNITSNSFICECDEQFSG 288
F C + F+G
Sbjct: 939 CQPVLQGFECIANAVFNG 956
Score = 31.6 bits (70), Expect = 2.3
Identities = 15/55 (27%), Positives = 24/55 (43%), Gaps = 1/55 (1%)
Query: 340 PCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPC 394
PC NG C +D C C + + C+ +Q C P + A C+ + + C
Sbjct: 895 PCHNGGVCHSRWDDFSCSCPALTSGKACEEVQW-CGFSPCPHGAQCQPVLQGFEC 948
Score = 30.4 bits (67), Expect = 5.0
Identities = 13/35 (37%), Positives = 18/35 (51%)
Query: 373 SCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEK 407
SC+S P N C D+ CSC + + K CE+
Sbjct: 890 SCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACEE 924
>gi|21704277 jagged 2 isoform a precursor [Homo sapiens]
Length = 1238
Score = 127 bits (320), Expect = 2e-29
Identities = 105/415 (25%), Positives = 148/415 (35%), Gaps = 65/415 (15%)
Query: 175 QESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRE 233
++ +S C G C E + + CHC FSG C+ ++D C PC+N C N
Sbjct: 499 RDECASSPCHSGGLC--EDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNL-- 554
Query: 234 NWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCF------------------------HGN 269
E Y C C F GKNCS C C HG
Sbjct: 555 ---EGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGR 611
Query: 270 CSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNG 329
C + +F C CD F+G +C + C+ G C + A+ CP G +
Sbjct: 612 CVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELC 671
Query: 330 ETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCE 389
+T+ ++ PC + C + ND C C + C S + C+++ N TC
Sbjct: 672 DTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSG 731
Query: 390 KDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLK 449
+ C+C G+ C A + L C+N C F +C G C
Sbjct: 732 DTFRCACPPGWKGSTCAVA-KNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTC--TH 788
Query: 450 NVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSEG----EKCQGVIDAYFFLAA 505
N + CY G GIC D G F GFAG + ++CQ AY A
Sbjct: 789 NTNDCNPLPCYNG----GICVD-GVNWFRCECAPGFAGPDCRINIDECQSSPCAY---GA 840
Query: 506 NCTED-------------ATYVNDPEDNNSSCW-----FPHEGTKEICANGCSCL 542
C ++ + SCW FPH + N C CL
Sbjct: 841 TCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCL 895
Score = 126 bits (316), Expect = 7e-29
Identities = 114/450 (25%), Positives = 158/450 (35%), Gaps = 66/450 (14%)
Query: 176 ESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDA--CSFKPCKNNGSCINKRE 233
+ +S C+ G C+ + + C C + G CQ LDA C KPC N SC N
Sbjct: 387 DECASNPCAAGGTCVDQV--DGFECICPEQWVGATCQ-LDANECEGKPCLNAFSCKNLIG 443
Query: 234 NWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEV 293
Y C C P + G NC + C+ C HG N + C C F G CE+
Sbjct: 444 G-----YYCDCIPGWKGINCHINVNDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGGRHCEL 497
Query: 294 SAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISND 353
C S G+C + + + CP+G S E DV PC+NG C + D
Sbjct: 498 ERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGD 557
Query: 354 VMCICSPIFTDLLCKSIQTSCESFPLRNNATCK--------------------KCEK--- 390
C C F C + C R C +C
Sbjct: 558 YYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPG 617
Query: 391 -DYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPG---------- 439
++ C C SGFT C + ID C L C N C + + F+ C G
Sbjct: 618 GNFSCICDSGFTGTYCHENIDDC--LGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNP 675
Query: 440 --CTKNPCWFLKNVY-LIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGV 496
C +PC Y L++ C C + G Q + + S G C
Sbjct: 676 NDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCD-----AYTCSNGGTCYDS 730
Query: 497 IDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCSCLSEEDSQEYRYLCFL 556
D + + +T NSSC P+ C NG +C+ S + +C
Sbjct: 731 GDTFRCACPPGWKGSTCA---VAKNSSC-LPNP-----CVNGGTCVGSGAS--FSCICRD 779
Query: 557 RWAGNMYLENTTDDQENECQHEAVCKDEIN 586
W G NT D C + +C D +N
Sbjct: 780 GWEGRTCTHNTNDCNPLPCYNGGICVDGVN 809
Score = 117 bits (294), Expect = 2e-26
Identities = 102/444 (22%), Positives = 165/444 (37%), Gaps = 58/444 (13%)
Query: 174 CQESLSSEFCSG-HGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKR 232
C+E++ + C+ HG C C C + G++C E C P +GSC+
Sbjct: 240 CKEAVCKQGCNLLHGGCTVPG-----ECRCSYGWQGRFCDE---CVPYPGCVHGSCV--- 288
Query: 233 ENWDEQAYECVCHPPFTGKNCSEIIGQC-QPHVCFHGN-CSNITSNSFICECDEQFSGPF 290
+ ++C C + G C + + C H C +G C N + + C C + +SG
Sbjct: 289 -----EPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRN 343
Query: 291 CEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKI 350
CE + C S G C S + CP G S D+ E + PC G C+
Sbjct: 344 CEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQ 403
Query: 351 SNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAID 410
+ CIC + C+ CE P N +CK Y C CI G+ NC ++
Sbjct: 404 VDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVN 463
Query: 411 HCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQ 470
C+ C + C +++ ++ VC G C ++ C+ G G+C+
Sbjct: 464 DCR---GQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDE--CASSPCHSG----GLCE 514
Query: 471 DKGPAQFEYVWQLGFAG---------------SEGEKCQGVIDAYF------FLAANCT- 508
D F GF+G G +C + Y+ F NC+
Sbjct: 515 DLADG-FHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSV 573
Query: 509 ------EDATYVNDPEDNNSSCWFPHEGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNM 562
A V D +++ P +C C+S+ + +C + G
Sbjct: 574 PREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGG-NFSCICDSGFTGTY 632
Query: 563 YLENTTDDQENECQHEAVCKDEIN 586
EN D C++ C DE++
Sbjct: 633 CHENIDDCLGQPCRNGGTCIDEVD 656
>gi|122937283 6720455I24Rik homolog [Homo sapiens]
Length = 1413
Score = 121 bits (303), Expect = 2e-27
Identities = 98/367 (26%), Positives = 143/367 (38%), Gaps = 52/367 (14%)
Query: 218 SFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNS 277
+ +PC N G CI+ + +Y C C FTG+ C + +C C +G NS
Sbjct: 274 ALRPCLNGGKCIDDCVTGNP-SYTCSCLSGFTGRRCHLDVNECASQPCQNGGTCTHGINS 332
Query: 278 FICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFS 337
F C+C F GP CE + PC + G C + + C G + E DV + S
Sbjct: 333 FRCQCPAGFGGPTCETAQSPCDTKECQHGGQCQVENGSAVCVCQAGYTGAACEMDVDDCS 392
Query: 338 LVPCQNGTDCIKISNDVMCICSPIFTDLLCKS----IQTSCESFPLRNNATCKKCEKDYP 393
PC NG C+ + + C+C+ F L C++ + +C S P N TC ++ Y
Sbjct: 393 PDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVDADQGYV 452
Query: 394 CSCISGFTEKNC-EKAIDHCKLLS-INCL--NEEWCFNIIGRFKYVCIPGCTKNPCWFLK 449
C C GF +C E+ D C+ + CL N C +G F +C T PC
Sbjct: 453 CECPEGFMGLDCRERVPDDCECRNGGRCLGANTTLCQCPLGFFGLLCEFEITAMPC---- 508
Query: 450 NVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTE 509
+ C D G Y + G GS C +A L + C
Sbjct: 509 --------------NMNTQCPDGG-----YCMEHG--GSYLCVCHTDHNASHSLPSPCDS 547
Query: 510 DATYVN---DPEDNNSSCWF-------------PHEGTKEICANGCSCLSEEDSQEYRYL 553
D + D D++ +C PH + C NG +C +E EY
Sbjct: 548 DPCFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTC--KEAGGEYHCS 605
Query: 554 CFLRWAG 560
C R+ G
Sbjct: 606 CPYRFTG 612
Score = 119 bits (297), Expect = 1e-26
Identities = 96/337 (28%), Positives = 140/337 (41%), Gaps = 42/337 (12%)
Query: 176 ESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQE-----LDACSFKPCKNNGSCIN 230
+ S + C G C+ + Y+C C PF G C+ DAC PC N G+C++
Sbjct: 389 DDCSPDPCLNGGSCVDLVGN--YTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVD 446
Query: 231 KRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSN----ITSNSFICECDEQF 286
+Q Y C C F G +C E + P C C N + +N+ +C+C F
Sbjct: 447 A-----DQGYVCECPEGFMGLDCRERV----PDDC---ECRNGGRCLGANTTLCQCPLGF 494
Query: 287 SGPFCE--VSAKPC-VSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQN 343
G CE ++A PC ++ G C +Y C ++ + + PC N
Sbjct: 495 FGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHNASHSLPSPCDSD--PCFN 552
Query: 344 GTDCIKISNDVMCICSPIFTDLLCKSIQTS-CESFPLRNNATCKKCEKDYPCSCISGFTE 402
G C + C C F C+ + C S P RN TCK+ +Y CSC FT
Sbjct: 553 GGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYHCSCPYRFTG 612
Query: 403 KNCE-KAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYC 461
++CE D C S C N CF+ IG++K C PG + C + + C
Sbjct: 613 RHCEIGKPDSC--ASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSP--CFRSPCVN 668
Query: 462 GVTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVID 498
G G C+D+ F + AG G +CQ +D
Sbjct: 669 G----GTCEDRDTDFFCHCQ----AGYMGRRCQAEVD 697
Score = 98.6 bits (244), Expect = 2e-20
Identities = 70/288 (24%), Positives = 104/288 (36%), Gaps = 56/288 (19%)
Query: 176 ESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFK-PCKNNGSCINKREN 234
+S +S C G C + Y C C P FSG++C+ + F+ PC N G+C ++ +
Sbjct: 621 DSCASGPCHNGGTCFH--YIGKYKCDCPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRDTD 678
Query: 235 WD---EQAY-------ECVCHPP---------FTGKNCSEI----------------IGQ 259
+ + Y E C PP F G + I
Sbjct: 679 FFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRV 738
Query: 260 CQPH------------------VCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSL 301
CQPH C HG ++C C + G CE+ C +
Sbjct: 739 CQPHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELERDECRAH 798
Query: 302 LFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPI 361
G C N AY CP G + ET+V PCQ+G C +C+C
Sbjct: 799 PCRNGGSCRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRCESGGGAYLCVCPES 858
Query: 362 FTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAI 409
F C+++ C S P C + C+C G+T ++C K +
Sbjct: 859 FFGYHCETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGEDCAKEL 906
Score = 55.8 bits (133), Expect = 1e-07
Identities = 34/120 (28%), Positives = 49/120 (40%), Gaps = 8/120 (6%)
Query: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQAYE 241
C G C + + Y C C F G +C+ E+DAC PC++ G C + AY
Sbjct: 800 CRNGGSCRNLPGA--YVCRCPAGFVGVHCETEVDACDSSPCQHGGRCES-----GGGAYL 852
Query: 242 CVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSL 301
CVC F G +C + C C ++ S C C ++G C P +L
Sbjct: 853 CVCPESFFGYHCETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGEDCAKELFPPTAL 912
Score = 35.0 bits (79), Expect = 0.20
Identities = 18/75 (24%), Positives = 32/75 (42%), Gaps = 11/75 (14%)
Query: 246 PPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVS----AKPCVSL 301
P K+ + G C + C +G +++ C+C F G CE++ ++PC L
Sbjct: 1297 PEHGSKDIGNVPGNCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKVSRPCTRL 1356
Query: 302 L-------FWKRGIC 309
W+ G+C
Sbjct: 1357 FSETKAFPVWEGGVC 1371
Score = 35.0 bits (79), Expect = 0.20
Identities = 14/37 (37%), Positives = 20/37 (54%), Gaps = 5/37 (13%)
Query: 217 CSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNC 253
CS PC+N G+C+ + A+ C C P F G+ C
Sbjct: 1311 CSENPCQNGGTCVPGAD-----AHSCDCGPGFKGRRC 1342
Score = 33.1 bits (74), Expect = 0.78
Identities = 23/94 (24%), Positives = 35/94 (37%), Gaps = 14/94 (14%)
Query: 369 SIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLN-EEWCFN 427
++ +C P +N TC + C C GF + CE A C+ C
Sbjct: 1306 NVPGNCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELA----------CIKVSRPCTR 1355
Query: 428 IIGRFKYVCIPGCTKNPCWFL-KNVYLIHQHLCY 460
+ K P C + K VY +HQ +C+
Sbjct: 1356 LFSETK--AFPVWEGGVCHHVYKRVYRVHQDICF 1387
Score = 30.0 bits (66), Expect = 6.6
Identities = 16/57 (28%), Positives = 24/57 (42%), Gaps = 11/57 (19%)
Query: 340 PCQNGTDCIKISNDVMCICSPIF----TDLLCKSIQTSC-------ESFPLRNNATC 385
PCQNG C+ ++ C C P F +L C + C ++FP+ C
Sbjct: 1315 PCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKVSRPCTRLFSETKAFPVWEGGVC 1371
>gi|112420992 crumbs homolog 2 [Homo sapiens]
Length = 1285
Score = 112 bits (279), Expect = 1e-24
Identities = 92/394 (23%), Positives = 137/394 (34%), Gaps = 81/394 (20%)
Query: 153 ASGPSPCPLGLRLNVTVKQQFCQESLSSEFCSG----HGK-CLSEAWSKT-YSCHCQPPF 206
A PC G T + + C+ HG C+ + T + C+C P F
Sbjct: 41 ACASDPCAPGTECQATESGGYTCGPMEPRGCATQPCHHGALCVPQGPDPTGFRCYCVPGF 100
Query: 207 SGKYCQ-ELDACSFKPCKNNGSCINKRENW-----------------DEQA--------- 239
G C+ ++D C+ +PC + +C N + + DE A
Sbjct: 101 QGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEVDECASAPCLHGGS 160
Query: 240 -------YECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICEC-DEQFSGPFC 291
+ CVC P + G C + +CQ C HG + N F C+C + G C
Sbjct: 161 CLDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNGFRCDCAGTGYEGTHC 220
Query: 292 EVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKIS 351
E C S C ++ C G S + E D E + PCQ+G C++ S
Sbjct: 221 EREVLECASAPCEHNASCLEGLGSFRCLCWPGYSGELCEVDEDECASSPCQHGGRCLQRS 280
Query: 352 NDV---------------------MCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEK 390
+ +C C P F C C S P N C+
Sbjct: 281 DPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCGVEVDECASRPCLNGGHCQDLPN 340
Query: 391 DYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNII------------GRFKYVCIP 438
+ C C G+ CE+ +D C LS CL+ C + + GR V +
Sbjct: 341 GFQCHCPDGYAGPTCEEDVDEC--LSDPCLHGGTCSDTVAGYICRCPETWGGRDCSVQLT 398
Query: 439 GCTKNPCWFLKNVYLI-----HQHLCYCGVTFHG 467
GC + C I H ++C+C HG
Sbjct: 399 GCQGHTCPLAATCIPIFESGVHSYVCHCPPGTHG 432
Score = 95.1 bits (235), Expect = 2e-19
Identities = 90/395 (22%), Positives = 131/395 (33%), Gaps = 83/395 (21%)
Query: 216 ACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNC---SN 272
AC+ PC C + + Y C P + C+ QP C HG
Sbjct: 41 ACASDPCAPGTEC----QATESGGYTC---GPMEPRGCAT-----QP--CHHGALCVPQG 86
Query: 273 ITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETD 332
F C C F GP CE+ C S C N + Y CP G + E +
Sbjct: 87 PDPTGFRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEME 146
Query: 333 VSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDY 392
V E + PC +G C+ C+C+P + C+ C+S P + TC +
Sbjct: 147 VDECASAPCLHGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNGF 206
Query: 393 PCSCI-SGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPG------------ 439
C C +G+ +CE+ + C S C + C +G F+ +C PG
Sbjct: 207 RCDCAGTGYEGTHCEREVLEC--ASAPCEHNASCLEGLGSFRCLCWPGYSGELCEVDEDE 264
Query: 440 CTKNPCWFLKNVYLIHQHLCYC----GVTFHGICQDKGPAQFEYVWQLGF-----AGSEG 490
C +PC QH C +G Q P F + GF G EG
Sbjct: 265 CASSPC----------QHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEG 314
Query: 491 EKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCSCLSEEDSQEY 550
C +D E C NG C ++ +
Sbjct: 315 ADCGVEVD------------------------------ECASRPCLNGGHC--QDLPNGF 342
Query: 551 RYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEI 585
+ C +AG E+ + + C H C D +
Sbjct: 343 QCHCPDGYAGPTCEEDVDECLSDPCLHGGTCSDTV 377
Score = 74.7 bits (182), Expect = 2e-13
Identities = 44/161 (27%), Positives = 64/161 (39%), Gaps = 8/161 (4%)
Query: 211 CQELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNC 270
C+ C+ PC ++G+C R+ +D A+ C C P + G C + C C G C
Sbjct: 1054 CRGAPVCAPSPCLHDGAC---RDLFD--AFACACGPGWEGPRCEAHVDPCHSAPCARGRC 1108
Query: 271 SNITSNSFICECDEQFSGPFCE--VSAKPC-VSLLFWKRGICPNSSSAYTYECPKGSSSQ 327
F C C F GP C V +K C +++ C S A C +G + Q
Sbjct: 1109 HTHPDGRFECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQ 1168
Query: 328 NGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCK 368
+ PC NG C CIC+ F+ C+
Sbjct: 1169 RCQVPTLPCEANPCLNGGTCRAAGGVSECICNARFSGQFCE 1209
Score = 60.8 bits (146), Expect = 3e-09
Identities = 35/121 (28%), Positives = 53/121 (43%), Gaps = 12/121 (9%)
Query: 176 ESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQE-LDACSFKPCKNNGSCINKREN 234
+ +S C G C + + CHC ++G C+E +D C PC + G+C +
Sbjct: 322 DECASRPCLNGGHC--QDLPNGFQCHCPDGYAGPTCEEDVDECLSDPCLHGGTCSDT--- 376
Query: 235 WDEQAYECVCHPPFTGKNCSEIIGQCQPHVC-FHGNCSNITSN---SFICECDEQFSGPF 290
Y C C + G++CS + CQ H C C I + S++C C GPF
Sbjct: 377 --VAGYICRCPETWGGRDCSVQLTGCQGHTCPLAATCIPIFESGVHSYVCHCPPGTHGPF 434
Query: 291 C 291
C
Sbjct: 435 C 435
Score = 50.1 bits (118), Expect = 6e-06
Identities = 29/98 (29%), Positives = 41/98 (41%), Gaps = 3/98 (3%)
Query: 198 YSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRE-NWDEQAYECVCHPPFTGKNCSEI 256
+ C C P F G C+ L S K C N +C++ A C C G+ C
Sbjct: 1116 FECRCPPGFGGPRCR-LPVPS-KECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVP 1173
Query: 257 IGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVS 294
C+ + C +G C C+ +FSG FCEV+
Sbjct: 1174 TLPCEANPCLNGGTCRAAGGVSECICNARFSGQFCEVA 1211
Score = 40.4 bits (93), Expect = 0.005
Identities = 23/80 (28%), Positives = 34/80 (42%), Gaps = 7/80 (8%)
Query: 211 CQELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNC 270
C D CS PC N G+C+ W++ + C C FTG C++ + C C
Sbjct: 805 CVSEDMCSPDPCFNGGTCL---VTWND--FHCTCPANFTGPTCAQQL-WCPGQPCLPPAT 858
Query: 271 SNITSNSFICECDEQF-SGP 289
+ F+C + F GP
Sbjct: 859 CEEVPDGFVCVAEATFREGP 878
Score = 37.7 bits (86), Expect = 0.032
Identities = 14/32 (43%), Positives = 17/32 (53%)
Query: 260 CQPHVCFHGNCSNITSNSFICECDEQFSGPFC 291
C P CF+G +T N F C C F+GP C
Sbjct: 811 CSPDPCFNGGTCLVTWNDFHCTCPANFTGPTC 842
Score = 37.7 bits (86), Expect = 0.032
Identities = 21/63 (33%), Positives = 26/63 (41%), Gaps = 1/63 (1%)
Query: 340 PCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISG 399
PC NG C+ ND C C FT C Q C P ATC++ + C +
Sbjct: 815 PCFNGGTCLVTWNDFHCTCPANFTGPTCAQ-QLWCPGQPCLPPATCEEVPDGFVCVAEAT 873
Query: 400 FTE 402
F E
Sbjct: 874 FRE 876
Score = 32.7 bits (73), Expect = 1.0
Identities = 18/66 (27%), Positives = 27/66 (40%), Gaps = 2/66 (3%)
Query: 374 CESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFK 433
C P ++ C+ + C+C G+ CE +D C S C + GRF+
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCH--SAPCARGRCHTHPDGRFE 1117
Query: 434 YVCIPG 439
C PG
Sbjct: 1118 CRCPPG 1123
Score = 31.2 bits (69), Expect = 3.0
Identities = 42/167 (25%), Positives = 57/167 (34%), Gaps = 37/167 (22%)
Query: 434 YVCIP----GCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSE 489
Y C P GC PC H LC + Q P F GF +
Sbjct: 61 YTCGPMEPRGCATQPCH--------HGALC--------VPQGPDPTGFRCYCVPGF---Q 101
Query: 490 GEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEG-TKEI---------CANGC 539
G +C+ ID + C AT N + C + G T E+ C +G
Sbjct: 102 GPRCELDIDEC--ASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEVDECASAPCLHGG 159
Query: 540 SCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEIN 586
SCL S +R +C + G + + Q C H C D +N
Sbjct: 160 SCLDGVGS--FRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVN 204
Score = 30.8 bits (68), Expect = 3.9
Identities = 14/47 (29%), Positives = 22/47 (46%), Gaps = 5/47 (10%)
Query: 211 CQELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEII 257
C+ + C PC + GSC+ + W + C C P G C++ I
Sbjct: 603 CERREQCRPLPCVHGGSCV---DLWTH--FRCDCARPHRGPTCADEI 644
Score = 30.4 bits (67), Expect = 5.0
Identities = 30/119 (25%), Positives = 44/119 (36%), Gaps = 23/119 (19%)
Query: 111 FVGCVQNTTTEDQLLFGCRLKGMHTVNSKWLSVGTHYFITVMASGPSPCPLGLRLNVTVK 170
F GC+Q D L GC L +F + + P LG R + +
Sbjct: 763 FRGCLQ-----DLRLDGCHLP---------------FFPLPLDNSSQPSELGGRQSWNLT 802
Query: 171 QQFCQESLSS-EFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSC 228
E + S + C G CL W+ + C C F+G C + C +PC +C
Sbjct: 803 AGCVSEDMCSPDPCFNGGTCLV-TWND-FHCTCPANFTGPTCAQQLWCPGQPCLPPATC 859
Score = 29.6 bits (65), Expect = 8.6
Identities = 18/63 (28%), Positives = 24/63 (38%), Gaps = 4/63 (6%)
Query: 259 QCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTY 318
QC+P C HG F C+C GP C + + G P+S+S
Sbjct: 608 QCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCADE----IPAATFGLGGAPSSASFLLQ 663
Query: 319 ECP 321
E P
Sbjct: 664 ELP 666
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 108 bits (269), Expect = 2e-23
Identities = 71/275 (25%), Positives = 117/275 (42%), Gaps = 23/275 (8%)
Query: 159 CPLGLRLNVTVKQQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDAC 217
C + +N+ K C LS+ C G C S+ Y C C F G+ C + AC
Sbjct: 907 CQGPVDVNILAK---CNPCLSNP-CKNDGTCNSDPVD-FYRCTCPYGFKGQDCDVPIHAC 961
Query: 218 SFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNS 277
PCK+ G+C K +E + C+C F G+NC + C+ + C + + N+
Sbjct: 962 ISNPCKHGGTCHLKEG--EEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINN 1019
Query: 278 FICECDEQFSGPFCEVSAKPCVSLL--FWKRGICPNSSSAYTYECPKGSSSQNGETDVSE 335
+ C C +++G CE C L C + + +C G ++ + D +
Sbjct: 1020 YTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDD 1079
Query: 336 FSLVPCQNGTDCIKISNDVMCICSPIFTDLLCK-------SIQTSCESFPLRNNATCKKC 388
C+NG C N CIC ++ L C+ + C++F +N A C
Sbjct: 1080 CQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVR 1139
Query: 389 EKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEE 423
+ C C+ G+ + CE KL+S+N +N+E
Sbjct: 1140 INEPICQCLPGYQGEKCE------KLVSVNFINKE 1168
Score = 62.0 bits (149), Expect = 2e-09
Identities = 42/153 (27%), Positives = 61/153 (39%), Gaps = 4/153 (2%)
Query: 297 PCVSLLFWKRGICPNSS-SAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDC-IKISND- 353
PC+S G C + Y CP G Q+ + + PC++G C +K +
Sbjct: 921 PCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEED 980
Query: 354 -VMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHC 412
CIC+ F C+ CE NN+TC +Y C C +T + CE+ +D C
Sbjct: 981 GFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFC 1040
Query: 413 KLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPC 445
C ++ C FK C PG C
Sbjct: 1041 AQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHC 1073
Score = 50.4 bits (119), Expect = 5e-06
Identities = 37/157 (23%), Positives = 60/157 (38%), Gaps = 12/157 (7%)
Query: 260 CQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAK-PCVSLLFWKRGICPNSSSAYTY 318
C VC HG C + F CEC E + GP C+ PC+ P ++ +Y+
Sbjct: 1336 CHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSC 1395
Query: 319 ECPKGSSSQNGETDVSEFS---LVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCE 375
+C +G + + F+ + C++G + C CS +T C + SC
Sbjct: 1396 KCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDR-EISCR 1454
Query: 376 SFPLRN-------NATCKKCEKDYPCSCISGFTEKNC 405
+R+ A C+ +K C G C
Sbjct: 1455 GERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQC 1491
Score = 45.4 bits (106), Expect = 2e-04
Identities = 55/240 (22%), Positives = 86/240 (35%), Gaps = 66/240 (27%)
Query: 360 PIFTDLLCKSIQTSCESFPLRNNATCKKCEKD-YPCSCISGFTEKNCEKAIDHCKLLSIN 418
P+ ++L K C S P +N+ TC D Y C+C GF ++C+
Sbjct: 910 PVDVNILAKC--NPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCD------------ 955
Query: 419 CLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFE 478
V I C NPC G C K + +
Sbjct: 956 ----------------VPIHACISNPC------------------KHGGTCHLK-EGEED 980
Query: 479 YVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANG 538
W + G EGE C+ +D +C ++T V+ NN +C P E T E+C
Sbjct: 981 GFWCICADGFEGENCEVNVDDCE--DNDCENNSTCVDGI--NNYTCLCPPEYTGELCEEK 1036
Query: 539 CS-CLSEEDSQEYRYLCFLR-----------WAGNMYLENTTDDQENECQHEAVCKDEIN 586
C + + ++ C L + G + D Q+N+C++ A C D +N
Sbjct: 1037 LDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVN 1096
Score = 45.4 bits (106), Expect = 2e-04
Identities = 30/112 (26%), Positives = 45/112 (40%), Gaps = 11/112 (9%)
Query: 186 HGKCLSEAWSKTYSCHCQPPFSGKYCQEL--DACSFKPCKNNGSCINKRENWDEQAYECV 243
HG C + + ++C CQ + G C + D C C + G+C+ + +Y C
Sbjct: 1343 HGTCQPSSQAG-FTCECQEGWMGPLCDQRTNDPCLGNKCVH-GTCLPI----NAFSYSCK 1396
Query: 244 CHPPFTGKNCSE---IIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCE 292
C G C E + CQ C HG C CEC ++G C+
Sbjct: 1397 CLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCD 1448
Score = 39.7 bits (91), Expect = 0.008
Identities = 29/112 (25%), Positives = 43/112 (38%), Gaps = 18/112 (16%)
Query: 493 CQGVIDAYFFLAAN------CTEDATYVNDPED----------NNSSCWFP-HEGTKEIC 535
CQG +D N C D T +DP D C P H C
Sbjct: 907 CQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPC 966
Query: 536 ANGCSC-LSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEIN 586
+G +C L E + + +C + G N D ++N+C++ + C D IN
Sbjct: 967 KHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGIN 1018
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 107 bits (268), Expect = 2e-23
Identities = 87/351 (24%), Positives = 131/351 (37%), Gaps = 27/351 (7%)
Query: 123 QLLFGCRLKGMHTVNSKWLSVGTHYFITVMA-----SGPSPCPLGLR-LNVTVKQQFCQE 176
Q L RL +H + L G +T ++ + P C LR L+ VK + +
Sbjct: 829 QGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVKTGYKEP 888
Query: 177 SLSSEFCSG----HGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKR 232
++ C+G GK L +K + C P + + + D C PC+N G+C N
Sbjct: 889 GIAR--CAGPQDMEGKLLLTTPAKKFECQGPPTLAVQ--AKCDLCLSSPCQNQGTCHND- 943
Query: 233 ENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNS---FICECDEQFSGP 289
+ Y C C + G++C + C C +G + F C C F GP
Sbjct: 944 ---PLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGP 1000
Query: 290 FCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGE--TDVSEFSLVPCQNGTDC 347
C V+ CV G+C + YT +CP + E D+ L PCQ+ C
Sbjct: 1001 TCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQC 1060
Query: 348 IKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCE- 406
+ + C C P + C Q C +N A C Y C C G++ + CE
Sbjct: 1061 VGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEI 1120
Query: 407 ---KAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLI 454
C N C + R C+PG C L +V +
Sbjct: 1121 PPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECEKLLSVNFV 1171
Score = 59.3 bits (142), Expect = 1e-08
Identities = 64/235 (27%), Positives = 90/235 (38%), Gaps = 34/235 (14%)
Query: 374 CESFPLRNNATCKKCEKD-YPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGR- 431
C S P +N TC + Y C+C SG+ ++CE ++D C S C N C G
Sbjct: 929 CLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCS--SGPCENGGTCHAQEGED 986
Query: 432 --FKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSE 489
F C G C N H C G G+C D G + L + E
Sbjct: 987 APFTCSCPTGFEGPTCGV--NTDDCVDHACANG----GVCVD-GVGNYTCQCPLQY---E 1036
Query: 490 GEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTK----------EICANGC 539
G+ C+ ++D C +A V P+ C + G C NG
Sbjct: 1037 GKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGA 1096
Query: 540 SCLSEEDSQEYRYLCFLRWAGNM-----YLENTTDDQEN-ECQHEAVCKDEINRP 588
C+ E +S Y LC ++G + +L E ECQ+ A C D+ NRP
Sbjct: 1097 QCMDEVNS--YSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRP 1149
Score = 53.5 bits (127), Expect = 6e-07
Identities = 31/110 (28%), Positives = 47/110 (42%), Gaps = 7/110 (6%)
Query: 186 HGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYECVCH 245
HG C A + CHC+ + G +C D + PC + + D +Y C C
Sbjct: 1349 HGICQPNA-TPGPMCHCEAGWVGLHC---DQPADGPCHGHKCVHGQCVPLDALSYSCQCQ 1404
Query: 246 PPFTGKNCSE---IIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCE 292
++G C++ + C+ C HG+C + C CD FSG CE
Sbjct: 1405 DGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCE 1454
Score = 50.1 bits (118), Expect = 6e-06
Identities = 34/144 (23%), Positives = 56/144 (38%), Gaps = 43/144 (29%)
Query: 242 CVCHPPFTGKNCSEII-GQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVS---AKP 297
C C + G +C + G C H C HG C + + S+ C+C + +SG C + A+P
Sbjct: 1362 CHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSCQCQDGYSGALCNQAGALAEP 1421
Query: 298 CVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCI 357
C RG+ +C G +G + C+
Sbjct: 1422 C-------RGL----------QCLHGHCQASG---------------------TKGAHCV 1443
Query: 358 CSPIFTDLLCKSIQTSCESFPLRN 381
C P F+ LC+ ++ C P+R+
Sbjct: 1444 CDPGFSGELCEQ-ESECRGDPVRD 1466
Score = 45.8 bits (107), Expect = 1e-04
Identities = 40/144 (27%), Positives = 61/144 (42%), Gaps = 18/144 (12%)
Query: 186 HGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYECVCH 245
HG+C+ + +YSC CQ +SG C + A + +PC+ + + CVC
Sbjct: 1388 HGQCVPLD-ALSYSCQCQDGYSGALCNQAGALA-EPCRGLQCLHGHCQASGTKGAHCVCD 1445
Query: 246 PPFTGKNCSEIIGQCQ--PHVCFHGNCSNITSNSFICECDEQFSGPFCEVS--AKPCVSL 301
P F+G+ C E +C+ P FH + IC+ S C S + C
Sbjct: 1446 PGFSGELC-EQESECRGDPVRDFH----QVQRGYAICQTTRPLSWVECRGSCPGQGCCQG 1500
Query: 302 LFWKRGICPNSSSAYTYECPKGSS 325
L KR +T+EC G+S
Sbjct: 1501 LRLKR-------RKFTFECSDGTS 1517
Score = 32.7 bits (73), Expect = 1.0
Identities = 33/128 (25%), Positives = 46/128 (35%), Gaps = 21/128 (16%)
Query: 175 QESLSSEFCSG----HGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCIN 230
Q +E C G HG C + +K C C P FSG+ C++ C P ++
Sbjct: 1414 QAGALAEPCRGLQCLHGHCQASG-TKGAHCVCDPGFSGELCEQESECRGDPVRDFHQV-- 1470
Query: 231 KRENWDEQAYE-CVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGP 289
++ Y C P + C G C C G + F EC + S
Sbjct: 1471 ------QRGYAICQTTRPLSWVECR---GSCPGQGCCQG--LRLKRRKFTFECSDGTS-- 1517
Query: 290 FCEVSAKP 297
F E KP
Sbjct: 1518 FAEEVEKP 1525
>gi|74136023 delta-like 1 homolog [Homo sapiens]
Length = 383
Score = 105 bits (261), Expect = 2e-22
Identities = 62/201 (30%), Positives = 92/201 (45%), Gaps = 17/201 (8%)
Query: 174 CQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYC-QELDACSFKPCKNNGSCINKR 232
C + ++S C HG C + C C + G+ C +++ ACS PC NNG+C+
Sbjct: 54 CDQCVTSPGCL-HGLC-----GEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCV--- 104
Query: 233 ENWDEQAYECVCHPPFTGKNCSEIIGQC--QPHVCFHGNC---SNITSNSFICECDEQFS 287
+ D+ YEC C P ++GK+C + G C C HG ++ C C FS
Sbjct: 105 -SLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFS 163
Query: 288 GPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDC 347
G FCE+ A C G+C + + CP G + V+ + PCQNG C
Sbjct: 164 GNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTC 223
Query: 348 IKISN-DVMCICSPIFTDLLC 367
++ + C+C P FT L C
Sbjct: 224 LQHTQVSYECLCKPEFTGLTC 244
Score = 85.1 bits (209), Expect = 2e-16
Identities = 60/251 (23%), Positives = 93/251 (37%), Gaps = 54/251 (21%)
Query: 200 CHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQ 259
C CQP + G C D C P +G C + +C+C + G+ C +
Sbjct: 43 CRCQPGWQGPLC---DQCVTSPGCLHGLC--------GEPGQCICTDGWDGELCDRDVRA 91
Query: 260 CQPHVCFH-GNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTY 318
C C + G C ++ + C C +SG C+ PCV
Sbjct: 92 CSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVI------------------ 133
Query: 319 ECPKGSSSQNGETDVSEFSLVPCQNGTDCIKI---SNDVMCICSPIFTDLLCKSIQTSCE 375
NG PCQ+G C+ ++ C+C P F+ C+ + SC
Sbjct: 134 ---------NGS---------PCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCT 175
Query: 376 SFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCF-NIIGRFKY 434
P N+ C D+ C C +GF +K C + + +C S C N C + ++
Sbjct: 176 PNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNC--ASSPCQNGGTCLQHTQVSYEC 233
Query: 435 VCIPGCTKNPC 445
+C P T C
Sbjct: 234 LCKPEFTGLTC 244
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 101 bits (252), Expect = 2e-21
Identities = 68/261 (26%), Positives = 108/261 (41%), Gaps = 17/261 (6%)
Query: 159 CPLGLRLNVTVKQQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDAC 217
C + +N+ K C LSS C +G C + + Y C C + GK C ++ C
Sbjct: 905 CKGPVDINIVAK---CNACLSSP-CKNNGTCTQDP-VELYRCACPYSYKGKDCTVPINTC 959
Query: 218 SFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNS 277
PC++ G+C + D + C C F G+ C C+ + C + N+
Sbjct: 960 IQNPCQHGGTCHLSDSHKD--GFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINN 1017
Query: 278 FICECDEQFSGPFCEVSAKPCVSLL--FWKRGICPNSSSAYTYECPKGSSSQNGETDVSE 335
++C C ++G C+ CV L C ++ EC G S + ETD +
Sbjct: 1018 YVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDD 1077
Query: 336 FSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKS------IQTS-CESFPLRNNATCKKC 388
C++G C+ N C C F+ C+ +QTS C+ + +N A C
Sbjct: 1078 CVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVV 1137
Query: 389 EKDYPCSCISGFTEKNCEKAI 409
+++ C C GF CEK I
Sbjct: 1138 QQEPTCRCPPGFAGPRCEKLI 1158
Score = 100 bits (248), Expect = 5e-21
Identities = 56/215 (26%), Positives = 88/215 (40%), Gaps = 9/215 (4%)
Query: 197 TYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEI 256
T+ C+ P + +AC PCKNNG+C + Y C C + GK+C+
Sbjct: 900 THRFQCKGPVDINIVAKCNACLSSPCKNNGTCTQD----PVELYRCACPYSYKGKDCTVP 955
Query: 257 IGQCQPHVCFHGNCSNITSN---SFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSS 313
I C + C HG +++ + F C C F G CE++ C C +
Sbjct: 956 INTCIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGI 1015
Query: 314 SAYTYECPKGSSSQNGETDVSEF--SLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQ 371
+ Y CP + + + + L CQ+ CI + C C P ++ LC++
Sbjct: 1016 NNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDN 1075
Query: 372 TSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCE 406
C + R+ A C Y C+C GF+ CE
Sbjct: 1076 DDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCE 1110
Score = 82.8 bits (203), Expect = 9e-16
Identities = 62/232 (26%), Positives = 82/232 (35%), Gaps = 78/232 (33%)
Query: 183 CSGHGKC-LSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQAY 240
C G C LS++ +SC C F G+ C+ D C C+NN +C++ N Y
Sbjct: 964 CQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINN-----Y 1018
Query: 241 ECVCHPPFTGKNCSEIIGQCQP-------------------------------------- 262
C+C P +TG+ C E+I C P
Sbjct: 1019 VCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDC 1078
Query: 263 --HVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYEC 320
H C HG T N + C C + FSGPFCE P V L +S YE
Sbjct: 1079 VAHKCRHGAQCVDTINGYTCTCPQGFSGPFCE-HPPPMVLL---------QTSPCDQYE- 1127
Query: 321 PKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQT 372
CQNG CI + + C C P F C+ + T
Sbjct: 1128 --------------------CQNGAQCIVVQQEPTCRCPPGFAGPRCEKLIT 1159
Score = 62.0 bits (149), Expect = 2e-09
Identities = 45/176 (25%), Positives = 66/176 (37%), Gaps = 6/176 (3%)
Query: 298 CVSLLFWKRGICPNSS-SAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCI---KISND 353
C+S G C Y CP ++ ++ PCQ+G C +
Sbjct: 920 CLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDG 979
Query: 354 VMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCK 413
C C F C+ CE NNATC +Y C C +T + C++ IDHC
Sbjct: 980 FSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCV 1039
Query: 414 LLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIH--QHLCYCGVTFHG 467
C +E C + F C+PG + C + + H +H C T +G
Sbjct: 1040 PELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTING 1095
Score = 55.1 bits (131), Expect = 2e-07
Identities = 30/109 (27%), Positives = 50/109 (45%), Gaps = 5/109 (4%)
Query: 264 VCFHGNCSNITSNSFICECDEQFSGPFCEVSAK-PCVSLLFWKRGICPNSSSAYTYECPK 322
VC HG C ++ +S +CEC ++GP C+ A+ PC+ G C + ++Y +C +
Sbjct: 1337 VCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHR-CHHGKCVATGTSYMCKCAE 1395
Query: 323 GSSS---QNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCK 368
G N + S C +G I + C+C P F+ C+
Sbjct: 1396 GYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQ 1444
Score = 48.5 bits (114), Expect = 2e-05
Identities = 39/154 (25%), Positives = 58/154 (37%), Gaps = 20/154 (12%)
Query: 186 HGKCLSEAWSKTYSCHCQPPFSGKYCQE--LDACSFKPCKNNGSCINKRENWDEQAYECV 243
HG C S + C C+P ++G C + D C C ++G C+ + Y C
Sbjct: 1340 HGLCRSVE-KDSVVCECRPGWTGPLCDQEARDPCLGHRC-HHGKCVATGTS-----YMCK 1392
Query: 244 CHPPFTGKNC---SEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCV- 299
C + G C ++ C C HG C C C FSG C+ PC+
Sbjct: 1393 CAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQ-QENPCLG 1451
Query: 300 ----SLLFWKRGI--CPNSSSAYTYECPKGSSSQ 327
++ ++G C +S EC G Q
Sbjct: 1452 QVVREVIRRQKGYASCATASKVPIMECRGGCGPQ 1485
Score = 38.9 bits (89), Expect = 0.014
Identities = 57/240 (23%), Positives = 88/240 (36%), Gaps = 66/240 (27%)
Query: 360 PIFTDLLCKSIQTSCESFPLRNNATCKKCEKD-YPCSCISGFTEKNCEKAIDHCKLLSIN 418
P+ +++ K +C S P +NN TC + + Y C+C + K+C
Sbjct: 908 PVDINIVAKC--NACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCT------------ 953
Query: 419 CLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFE 478
V I C +NPC QH G T H D F
Sbjct: 954 ----------------VPINTCIQNPC----------QH----GGTCH--LSDSHKDGFS 981
Query: 479 YVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANG 538
LGF EG++C+ I+ +C +AT V+ NN C P T E+C
Sbjct: 982 CSCPLGF---EGQRCE--INPDDCEDNDCENNATCVDGI--NNYVCICPPNYTGELCDEV 1034
Query: 539 CS-CLSEEDSQEYRYLCFLR-----------WAGNMYLENTTDDQENECQHEAVCKDEIN 586
C+ E + ++ C ++G + + D ++C+H A C D IN
Sbjct: 1035 IDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTIN 1094
Score = 37.7 bits (86), Expect = 0.032
Identities = 28/113 (24%), Positives = 47/113 (41%), Gaps = 18/113 (15%)
Query: 492 KCQGVIDAYFFLAAN------CTEDATYVNDP-EDNNSSCWFPHEGT----------KEI 534
+C+G +D N C + T DP E +C + ++G +
Sbjct: 904 QCKGPVDINIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNP 963
Query: 535 CANGCSC-LSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEIN 586
C +G +C LS+ + C L + G N D ++N+C++ A C D IN
Sbjct: 964 CQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGIN 1016
Score = 35.0 bits (79), Expect = 0.20
Identities = 16/38 (42%), Positives = 22/38 (57%), Gaps = 1/38 (2%)
Query: 180 SEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDAC 217
S F HG+C + Y C CQP FSG++CQ+ + C
Sbjct: 1413 SAFKCHHGQCHISDQGEPY-CLCQPGFSGEHCQQENPC 1449
Score = 31.6 bits (70), Expect = 2.3
Identities = 29/118 (24%), Positives = 46/118 (38%), Gaps = 11/118 (9%)
Query: 337 SLVPCQNGTDCIKISND-VMCICSPIFTDLLC-KSIQTSCESFPLRNNATCKKCEKDYPC 394
S C++G C + D V+C C P +T LC + + C ++ C Y C
Sbjct: 1334 SCTVCKHGL-CRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRC-HHGKCVATGTSYMC 1391
Query: 395 SCISGFTEKNCEKAIDHCKLLS-INCLNEEWCFNIIGRFKYVCIPGCT------KNPC 445
C G+ C+ D S C + + + G +C PG + +NPC
Sbjct: 1392 KCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQENPC 1449
>gi|8393264 delta-like 3 protein isoform 1 precursor [Homo sapiens]
Length = 618
Score = 97.8 bits (242), Expect = 3e-20
Identities = 76/298 (25%), Positives = 103/298 (34%), Gaps = 51/298 (17%)
Query: 197 TYSCHCQPPFSGKYCQEL---------------------DACSFKPCKNNGSCINKRENW 235
+Y C+PP G C L D C P C + +
Sbjct: 173 SYRARCEPPAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECE-APLVCRAGC-SPEHGF 230
Query: 236 DEQAYECVCHPPFTGKNCSEII-----------------------GQCQPHVCFHGNCSN 272
EQ EC C +TG C+ + G C + C +G +
Sbjct: 231 CEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCS 290
Query: 273 ITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSS---SAYTYECPKGSSSQNG 329
T SF C C F G CEVS C + G+C + SAY CP G N
Sbjct: 291 ETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNC 350
Query: 330 ETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCE 389
E V SL PC+NG C+ + + + C C F C+ C N TC +
Sbjct: 351 EKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGG 410
Query: 390 KDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWF 447
+ CSC GF ++C + D C + C + C+ C PG C F
Sbjct: 411 GAHRCSCALGFGGRDCRERADPC--AARPCAHGGRCYAHFSGLVCACAPGYMGARCEF 466
Score = 87.0 bits (214), Expect = 5e-17
Identities = 49/187 (26%), Positives = 76/187 (40%), Gaps = 5/187 (2%)
Query: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDA-CSFKPCKNNGSCINKRENWDEQAYE 241
C+ G C SE +++ C C F G C+ C+ PC N G C+ + + AY
Sbjct: 283 CANGGSC-SET-PRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGAD--PDSAYI 338
Query: 242 CVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSL 301
C C P F G NC + + +C C +G ++ C C F+GP CE C
Sbjct: 339 CHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGR 398
Query: 302 LFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPI 361
G C A+ C G ++ + PC +G C + ++C C+P
Sbjct: 399 ACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPG 458
Query: 362 FTDLLCK 368
+ C+
Sbjct: 459 YMGARCE 465
Score = 62.0 bits (149), Expect = 2e-09
Identities = 38/140 (27%), Positives = 57/140 (40%), Gaps = 11/140 (7%)
Query: 159 CPLGLRLNVTVKQQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDAC 217
CP G + + K+ + S + C G CL C C+ F+G C+ +LD C
Sbjct: 341 CPPGFQGSNCEKRV---DRCSLQPCRNGGLCLD--LGHALRCRCRAGFAGPRCEHDLDDC 395
Query: 218 SFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNS 277
+ + C N G+C+ A+ C C F G++C E C C HG +
Sbjct: 396 AGRACANGGTCVE-----GGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSG 450
Query: 278 FICECDEQFSGPFCEVSAKP 297
+C C + G CE P
Sbjct: 451 LVCACAPGYMGARCEFPVHP 470
>gi|45243561 delta-like 3 protein isoform 2 precursor [Homo sapiens]
Length = 587
Score = 97.8 bits (242), Expect = 3e-20
Identities = 76/298 (25%), Positives = 103/298 (34%), Gaps = 51/298 (17%)
Query: 197 TYSCHCQPPFSGKYCQEL---------------------DACSFKPCKNNGSCINKRENW 235
+Y C+PP G C L D C P C + +
Sbjct: 173 SYRARCEPPAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECE-APLVCRAGC-SPEHGF 230
Query: 236 DEQAYECVCHPPFTGKNCSEII-----------------------GQCQPHVCFHGNCSN 272
EQ EC C +TG C+ + G C + C +G +
Sbjct: 231 CEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCS 290
Query: 273 ITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSS---SAYTYECPKGSSSQNG 329
T SF C C F G CEVS C + G+C + SAY CP G N
Sbjct: 291 ETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNC 350
Query: 330 ETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCE 389
E V SL PC+NG C+ + + + C C F C+ C N TC +
Sbjct: 351 EKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGG 410
Query: 390 KDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWF 447
+ CSC GF ++C + D C + C + C+ C PG C F
Sbjct: 411 GAHRCSCALGFGGRDCRERADPC--AARPCAHGGRCYAHFSGLVCACAPGYMGARCEF 466
Score = 87.0 bits (214), Expect = 5e-17
Identities = 49/187 (26%), Positives = 76/187 (40%), Gaps = 5/187 (2%)
Query: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDA-CSFKPCKNNGSCINKRENWDEQAYE 241
C+ G C SE +++ C C F G C+ C+ PC N G C+ + + AY
Sbjct: 283 CANGGSC-SET-PRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGAD--PDSAYI 338
Query: 242 CVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSL 301
C C P F G NC + + +C C +G ++ C C F+GP CE C
Sbjct: 339 CHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGR 398
Query: 302 LFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPI 361
G C A+ C G ++ + PC +G C + ++C C+P
Sbjct: 399 ACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPG 458
Query: 362 FTDLLCK 368
+ C+
Sbjct: 459 YMGARCE 465
Score = 62.0 bits (149), Expect = 2e-09
Identities = 38/140 (27%), Positives = 57/140 (40%), Gaps = 11/140 (7%)
Query: 159 CPLGLRLNVTVKQQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDAC 217
CP G + + K+ + S + C G CL C C+ F+G C+ +LD C
Sbjct: 341 CPPGFQGSNCEKRV---DRCSLQPCRNGGLCLD--LGHALRCRCRAGFAGPRCEHDLDDC 395
Query: 218 SFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNS 277
+ + C N G+C+ A+ C C F G++C E C C HG +
Sbjct: 396 AGRACANGGTCVE-----GGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSG 450
Query: 278 FICECDEQFSGPFCEVSAKP 297
+C C + G CE P
Sbjct: 451 LVCACAPGYMGARCEFPVHP 470
>gi|46397353 Notch homolog 2 N-terminal like protein [Homo sapiens]
Length = 236
Score = 97.8 bits (242), Expect = 3e-20
Identities = 58/216 (26%), Positives = 93/216 (43%), Gaps = 17/216 (7%)
Query: 200 CHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQ 259
C C F G+YCQ D C C+N G+C+ + C C FTG++C
Sbjct: 12 CKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKA---TCRCASGFTGEDCQ----Y 64
Query: 260 CQPHVCF-------HGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNS 312
H CF G C ++ +++ C C F+G C+ + C+S C
Sbjct: 65 STSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTTV 123
Query: 313 SSAYTYECPKGSSSQNGETDVSEFSLV-PCQNGTDCIKISNDVMCICSPIFTDLLCKSIQ 371
++ ++ +C G + Q ETDV+E + CQ+G C+ + C C FT C S+
Sbjct: 124 ANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLY 183
Query: 372 TSCESFPLRNNATCKKC-EKDYPCSCISGFTEKNCE 406
C P N TC++ + + C+C+ + E
Sbjct: 184 VPCAPSPCVNGGTCRQTGDFTFECNCLPETVRRGTE 219
Score = 86.3 bits (212), Expect = 8e-17
Identities = 55/196 (28%), Positives = 83/196 (42%), Gaps = 12/196 (6%)
Query: 172 QFCQ--ESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDA--CSF-KPCKNNG 226
++CQ + C G C+++A +C C F+G+ CQ + C +PC N G
Sbjct: 21 EYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGG 80
Query: 227 SCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQF 286
+C YEC C FTGK C + C H C +G+ +N F C+C F
Sbjct: 81 TC----HMLSRDTYECTCQVGFTGKEC-QWTDACLSHPCANGSTCTTVANQFSCKCLTGF 135
Query: 287 SGPFCEVSAKPC-VSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGT 345
+G CE C + G C N +Y +C +G + Q ++ + PC NG
Sbjct: 136 TGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGG 195
Query: 346 DCIKISNDVM-CICSP 360
C + + C C P
Sbjct: 196 TCRQTGDFTFECNCLP 211
Score = 80.9 bits (198), Expect = 3e-15
Identities = 50/181 (27%), Positives = 77/181 (42%), Gaps = 8/181 (4%)
Query: 270 CSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSS--SAYTYECPKGSSSQ 327
C + + C+C E F G +C+ PC G C + T C G + +
Sbjct: 2 CVTYHNGTGYCKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGE 60
Query: 328 NGETDVSEFSLV--PCQNGTDCIKISNDVM-CICSPIFTDLLCKSIQTSCESFPLRNNAT 384
+ + S V PC NG C +S D C C FT C+ +C S P N +T
Sbjct: 61 DCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTD-ACLSHPCANGST 119
Query: 385 CKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNP 444
C + C C++GFT + CE ++ C + +C + C N+ G ++ C+ G T
Sbjct: 120 CTTVANQFSCKCLTGFTGQKCETDVNECDIPG-HCQHGGTCLNLPGSYQCQCLQGFTGQY 178
Query: 445 C 445
C
Sbjct: 179 C 179
>gi|24430141 fibrillin 1 precursor [Homo sapiens]
Length = 2871
Score = 97.4 bits (241), Expect = 3e-20
Identities = 84/317 (26%), Positives = 118/317 (37%), Gaps = 55/317 (17%)
Query: 155 GPSPCPLGLRLNVTVKQQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFS----GKY 210
G C + T + FC + +G + +Y C CQP F+ +
Sbjct: 1176 GKYQCACNPGYHSTPDRLFCVDIDECSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRS 1235
Query: 211 CQELDACSFKP-CKNNGSCINKRENWDEQAYECVCHPPFTG----KNCSEIIGQC--QPH 263
C ++D C P + G C N Y C+C+ F K C + + +C P+
Sbjct: 1236 CTDIDECEDNPNICDGGQCTN-----IPGEYRCLCYDGFMASEDMKTCVD-VNECDLNPN 1289
Query: 264 VCFHGNCSNITSNSFICECDEQFSGP----------FCEVSAKPCVSLLFWKRGICPNSS 313
+C G C N T SFIC CD +SG CE+ A C K +C N++
Sbjct: 1290 ICLSGTCEN-TKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNC-----GKHAVCTNTA 1343
Query: 314 SAYTYECPKGSSSQNGE-TDVSEFSLVPCQNGT-------DCIKISNDVMCICSPIFT-- 363
++ C G + TD+ E C NGT DC C+C +T
Sbjct: 1344 GSFKCSCSPGWIGDGIKCTDLDE-----CSNGTHMCSQHADCKNTMGSYRCLCKEGYTGD 1398
Query: 364 DLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTE----KNCEKAIDHCKLLSINC 419
C + E+ L N C Y C C GF K CE ID C L +I
Sbjct: 1399 GFTCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACED-IDECSLPNICV 1457
Query: 420 LNEEWCFNIIGRFKYVC 436
C N+ G F+ C
Sbjct: 1458 FGT--CHNLPGLFRCEC 1472
Score = 91.7 bits (226), Expect = 2e-18
Identities = 95/328 (28%), Positives = 128/328 (39%), Gaps = 58/328 (17%)
Query: 197 TYSCHCQPPFS----GKYCQELDACSFKP--CKNNGSCINKRENWDEQAYECVCHPPFTG 250
TY C C P + G+ C + + C KP C+N G C+N R + Y C C+ FT
Sbjct: 2271 TYMCICGPGYQRRPDGEGCVDENECQTKPGICEN-GRCLNTRGS-----YTCECNDGFTA 2324
Query: 251 K-NCSEII----GQCQPHV----CFHGNCSNITSNSFICECDEQFS-GPFCEVSAKPCVS 300
N E + G C V C G+ + C CD GP CE
Sbjct: 2325 SPNQDECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCE-------- 2376
Query: 301 LLFWKRGICP-NSSSAYTYECPKGSSSQNGETDVSEFSLVP--CQNGTDCIKISNDVMCI 357
ICP + A+ CP G D+ E ++ C+NG +C+ CI
Sbjct: 2377 -------ICPFQGTVAFKKLCPHGRGFMTNGADIDECKVIHDVCRNG-ECVNDRGSYHCI 2428
Query: 358 C----SPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGF----TEKNCEKAI 409
C +P T C + C P N CK E Y CSC G+ ++C K +
Sbjct: 2429 CKTGYTPDITGTSCVDLN-ECNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRSC-KDL 2486
Query: 410 DHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGIC 469
D C NC + C N IG F C PG T++ + N + CG GIC
Sbjct: 2487 DECATKQHNC--QFLCVNTIGGFTCKCPPGFTQHHTSCIDNNECT-SDINLCG--SKGIC 2541
Query: 470 QDKGPAQFEYVWQLGFA-GSEGEKCQGV 496
Q+ P F Q GF+ G C+ V
Sbjct: 2542 QNT-PGSFTCECQRGFSLDQTGSSCEDV 2568
Score = 90.1 bits (222), Expect = 5e-18
Identities = 86/325 (26%), Positives = 130/325 (40%), Gaps = 73/325 (22%)
Query: 176 ESLSSEFCSGHGKCLSEAWSKTYSCHCQPPF----SGKYCQELDACSFKPCKNNGSCINK 231
E L + +G+C++ S + C C F GK C+++D CS + NG CIN
Sbjct: 533 ECLQNGRICNNGRCINTDGS--FHCVCNAGFHVTRDGKNCEDMDECSIRNMCLNGMCIN- 589
Query: 232 RENWDEQAYECVCHPPF----TGKNCSEIIGQCQ-PHVCFHGNCSNITSNSFICECDEQF 286
++ +++C+C P F G+ C + I +C+ P +C +G C N T S+ CEC F
Sbjct: 590 ----EDGSFKCICKPGFQLASDGRYCKD-INECETPGICMNGRCVN-TDGSYRCEC---F 640
Query: 287 SGPFCEVSAKPCVSLLF-------WKRGIC------------------------------ 309
G + + CV +KRG C
Sbjct: 641 PGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKPLFGAVTKSECCCASTEYAFGEPCQPCP 700
Query: 310 PNSSSAYTYECPKGSSSQNGETDVSEFSLVP--CQNGTDCIKISNDVMCICSPIF----T 363
+S+ Y C G + +D++E +L P C NG C + CIC+ + T
Sbjct: 701 AQNSAEYQALCSSGPGMTSAGSDINECALDPDICPNGI-CENLRGTYKCICNSGYEVDST 759
Query: 364 DLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTE----KNCEKAIDHCKLLSINC 419
C I + L +N C+ + C+C GF K CE ID C+ S C
Sbjct: 760 GKNCVDINECVLNSLLCDNGQCRNTPGSFVCTCPKGFIYKPDLKTCED-IDECE--SSPC 816
Query: 420 LNEEWCFNIIGRFKYVCIPGCTKNP 444
+N C N G F C T +P
Sbjct: 817 INGV-CKNSPGSFICECSSESTLDP 840
Score = 77.4 bits (189), Expect = 4e-14
Identities = 72/291 (24%), Positives = 109/291 (37%), Gaps = 42/291 (14%)
Query: 178 LSSEFCSGHGKCLSEAWSKTYSCHCQPPFSG-----KYCQELDACSFKPCKNNGSCINKR 232
+S + C G G+C++ + C C + K C ++D C P G +
Sbjct: 1076 ISPDLC-GRGQCVNTPGD--FECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGGVCHNT 1132
Query: 233 ENWDEQAYECVCHPPFTGKNCSEIIGQC--------QPHVCFHGNCSNITSNSFICECDE 284
E +Y C C P G S I C H+C +G C N+ + C C+
Sbjct: 1133 EG----SYRCECPP---GHQLSPNISACIDINECELSAHLCPNGRCVNLIGK-YQCACNP 1184
Query: 285 QFSGP----FCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSS---SQNGETDVSEFS 337
+ FC V C + C NS +Y C G + Q TD+ E
Sbjct: 1185 GYHSTPDRLFC-VDIDECSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTDIDECE 1243
Query: 338 LVP--CQNGTDCIKISNDVMCICSPIFT---DLLCKSIQTSCESFP-LRNNATCKKCEKD 391
P C G C I + C+C F D+ C+ P + + TC+ +
Sbjct: 1244 DNPNICDGG-QCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTKGS 1302
Query: 392 YPCSCISGFTEKNCEKA---IDHCKLLSINCLNEEWCFNIIGRFKYVCIPG 439
+ C C G++ K + I+ C++ + NC C N G FK C PG
Sbjct: 1303 FICHCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPG 1353
Score = 75.9 bits (185), Expect = 1e-13
Identities = 103/468 (22%), Positives = 176/468 (37%), Gaps = 103/468 (22%)
Query: 159 CPLGLRL--NVTVKQQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGK----YCQ 212
CP G +L N++ + LS+ C +G+C++ Y C C P + +C
Sbjct: 1140 CPPGHQLSPNISACIDINECELSAHLCP-NGRCVNLIGK--YQCACNPGYHSTPDRLFCV 1196
Query: 213 ELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFT----GKNCSEIIGQCQ--PHVCF 266
++D CS NG C N E +YEC C P F ++C++I +C+ P++C
Sbjct: 1197 DIDECSIM----NGGCETFCTN-SEGSYECSCQPGFALMPDQRSCTDI-DECEDNPNICD 1250
Query: 267 HGNCSNITSNSFICECDEQFSGPF----------CEVSAKPCVSLLFWKRGICPNSSSAY 316
G C+NI + C C + F C+++ C+S G C N+ ++
Sbjct: 1251 GGQCTNIPGE-YRCLCYDGFMASEDMKTCVDVNECDLNPNICLS------GTCENTKGSF 1303
Query: 317 TYECPKGSSSQNGETDVSEFSLVPCQNGT-DCIKISNDVMCICSPIFTDLLCKSIQTSCE 375
C G S + G+T ++ + C+ G +C K
Sbjct: 1304 ICHCDMGYSGKKGKTGCTDIN--ECEIGAHNCGK-------------------------- 1335
Query: 376 SFPLRNNATCKKCEKDYPCSCISGFTEKNCEKA-IDHCKLLSINCLNEEWCFNIIGRFKY 434
+A C + CSC G+ + +D C + C C N +G ++
Sbjct: 1336 ------HAVCTNTAGSFKCSCSPGWIGDGIKCTDLDECSNGTHMCSQHADCKNTMGSYRC 1389
Query: 435 VCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGS-EGEKC 493
+C G T + + ++ ++L CG +G C + P + +GF S +G+ C
Sbjct: 1390 LCKEGYTGDG-FTCTDLDECSENLNLCG---NGQCLN-APGGYRCECDMGFVPSADGKAC 1444
Query: 494 QGVID------AYFFLAAN------CTEDATYVNDPEDNN----SSCWFPHEGTKEICAN 537
+ + + F N C + Y D N + C P C N
Sbjct: 1445 EDIDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNECLDPTTCISGNCVN 1504
Query: 538 G-----CSCLSEEDSQEYRYLCFLRWAGNMYLE--NTTDDQENECQHE 578
C C + + R C +GN YL+ D+ + C +E
Sbjct: 1505 TPGSYICDCPPDFELNPTRVGCVDTRSGNCYLDIRPRGDNGDTACSNE 1552
Score = 67.0 bits (162), Expect = 5e-11
Identities = 77/280 (27%), Positives = 107/280 (38%), Gaps = 41/280 (14%)
Query: 186 HGKCLSEAWSKTYSCHCQPPFSGK----YCQELDACSFKP-CKNNGSCINKRENWDEQAY 240
+G C++ S + C C F C+++D C P C+ N CIN + Y
Sbjct: 1779 NGVCINMVGS--FRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNAECINTAGS-----Y 1831
Query: 241 ECVCHPP--FTGKNCSEIIGQCQ--PHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAK 296
C C P FT +CQ P++C HG C + T SF C C F
Sbjct: 1832 RCDCKPGYRFTSTGQCNDRNECQEIPNICSHGQCID-TVGSFYCLCHTGFK---TNDDQT 1887
Query: 297 PCVSLLFWKR-----GICPNSSSAYTYECPKGS--SSQNGETDVSEFSLVP---CQNGTD 346
C+ + +R G C N+ ++ C G S N DV E + C+NG
Sbjct: 1888 MCLDINECERDACGNGTCRNTIGSFNCRCNHGFILSHNNDCIDVDECASGNGNLCRNG-Q 1946
Query: 347 CIKISNDVMCICSPIFT----DLLCKSIQTSCESFPLR-NNATCKKCEKDYPCSCISGFT 401
CI C C+ + C I C P + TC+ + Y C C G++
Sbjct: 1947 CINTVGSFQCQCNEGYEVAPDGRTCVDIN-ECLLEPRKCAPGTCQNLDGSYRCICPPGYS 2005
Query: 402 EKN--CEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPG 439
+N CE ID C C C N G FK +C G
Sbjct: 2006 LQNEKCED-IDECVEEPEICALGT-CSNTEGSFKCLCPEG 2043
Score = 67.0 bits (162), Expect = 5e-11
Identities = 74/302 (24%), Positives = 111/302 (36%), Gaps = 66/302 (21%)
Query: 197 TYSCHCQPPFS--GKYCQELDACSFKP--CKNNGSCINKRENWDEQAYECVCHPPFT--- 249
+Y C C P +S + C+++D C +P C G+C N E +++C+C F+
Sbjct: 1995 SYRCICPPGYSLQNEKCEDIDECVEEPEICAL-GTCSNT-----EGSFKCLCPEGFSLSS 2048
Query: 250 -GKNCSEIIGQCQPHVCFH----GNCS-----NITSNSFICECDEQFSGPFCE------- 292
G+ C ++ + C+ G CS N + C + G CE
Sbjct: 2049 SGRRCQDL----RMSYCYAKFEGGKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPD 2104
Query: 293 ---------------------VSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGE- 330
V C K G C N+ +Y ECP G E
Sbjct: 2105 EAFRQICPYGSGIIVGPDDSAVDMDECKEPDVCKHGQCINTDGSYRCECPFGYILAGNEC 2164
Query: 331 TDVSEFSLV-PCQNGTDCIKISNDVMCICSPIFTD---LLCKSIQTSCESFPLRNNATCK 386
D E S+ PC NGT C + C C F + C+ I C PL C
Sbjct: 2165 VDTDECSVGNPCGNGT-CKNVIGGFECTCEEGFEPGPMMTCEDIN-ECAQNPLLCAFRCV 2222
Query: 387 KCEKDYPCSCISGFT---EKNCEKAIDHCKLLSINCLNEEW-CFNIIGRFKYVCIPGCTK 442
Y C C G+ ++ K D C+ +C ++ C N+IG + +C PG +
Sbjct: 2223 NTYGSYECKCPVGYVLREDRRMCKDEDECEEGKHDCTEKQMECKNLIGTYMCICGPGYQR 2282
Query: 443 NP 444
P
Sbjct: 2283 RP 2284
Score = 65.5 bits (158), Expect = 1e-10
Identities = 78/296 (26%), Positives = 109/296 (36%), Gaps = 60/296 (20%)
Query: 177 SLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGK--YCQELDACS--FKPCKNNGSCINKR 232
S + CS H C + S Y C C+ ++G C +LD CS C NG C+N
Sbjct: 1368 SNGTHMCSQHADCKNTMGS--YRCLCKEGYTGDGFTCTDLDECSENLNLC-GNGQCLNA- 1423
Query: 233 ENWDEQAYECVCH----PPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQF-- 286
Y C C P GK C +I P++C G C N+ F CEC+ +
Sbjct: 1424 ----PGGYRCECDMGFVPSADGKACEDIDECSLPNICVFGTCHNL-PGLFRCECEIGYEL 1478
Query: 287 --SGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNG 344
SG C C+ G C N+ +Y +CP + E + + V ++G
Sbjct: 1479 DRSGGNC-TDVNECLDPTTCISGNCVNTPGSYICDCP-----PDFELNPTRVGCVDTRSG 1532
Query: 345 TDCIKI-----------SNDV-------MCICSPIFTDLLCKSIQTSCESFPLRNNATCK 386
+ I SN++ C CS L K+ T CE P N +
Sbjct: 1533 NCYLDIRPRGDNGDTACSNEIGVGVSKASCCCS------LGKAWGTPCEMCPAVNTS--- 1583
Query: 387 KCEKDYPCSCISGFTEKNCE---KAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPG 439
E C GF + ID C+ L C + C N G F+ C G
Sbjct: 1584 --EYKILCPGGEGFRPNPITVILEDIDECQELPGLCQGGK-CINTFGSFQCRCPTG 1636
Score = 64.7 bits (156), Expect = 2e-10
Identities = 74/278 (26%), Positives = 112/278 (40%), Gaps = 39/278 (14%)
Query: 186 HGKCLSEAWSKTYSCHCQ----PPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYE 241
+G+C+++ S Y C C+ P +G C +L+ C+ P N C N E +Y+
Sbjct: 2415 NGECVNDRGS--YHCICKTGYTPDITGTSCVDLNECNQAPKPCNFICKNT-----EGSYQ 2467
Query: 242 CVCHPPFT----GKNCSEIIGQC--QPHVCFHGNCSNITSNSFICECDEQFSGPFCE-VS 294
C C + G++C ++ +C + H C C N T F C+C F+ +
Sbjct: 2468 CSCPKGYILQEDGRSCKDL-DECATKQHNC-QFLCVN-TIGGFTCKCPPGFTQHHTSCID 2524
Query: 295 AKPCVS--LLFWKRGICPNSSSAYTYECPKGSS-SQNGET--DVSEFS-LVPCQNGTDCI 348
C S L +GIC N+ ++T EC +G S Q G + DV E CQ+G C
Sbjct: 2525 NNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCEDVDECEGNHRCQHG--CQ 2582
Query: 349 KISNDVMCICSPIFTDLL----CKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKN 404
I C C + C + C S + A+C Y C C +GF +
Sbjct: 2583 NIIGGYRCSCPQGYLQHYQWNQCVD-ENECLSAHICGGASCHNTLGSYKCMCPAGFQYEQ 2641
Query: 405 CE---KAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPG 439
+ I+ C C C N G + C PG
Sbjct: 2642 FSGGCQDINECGSAQAPC--SYGCSNTEGGYLCGCPPG 2677
Score = 60.8 bits (146), Expect = 3e-09
Identities = 76/318 (23%), Positives = 122/318 (38%), Gaps = 51/318 (16%)
Query: 186 HGKCLSEAWSKTYSCHCQPPFS----GKYCQELDACSFKPCK-NNGSCINKRENWDEQAY 240
+G+C++ S + C C + G+ C +++ C +P K G+C N + +Y
Sbjct: 1944 NGQCINTVGS--FQCQCNEGYEVAPDGRTCVDINECLLEPRKCAPGTCQNL-----DGSY 1996
Query: 241 ECVCHPPFTGKNCS-EIIGQC--QPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKP 297
C+C P ++ +N E I +C +P +C G CSN T SF C C E FS S +
Sbjct: 1997 RCICPPGYSLQNEKCEDIDECVEEPEICALGTCSN-TEGSFKCLCPEGFS---LSSSGRR 2052
Query: 298 CVSLLF------WKRGIC--PNSSSAYTYEC-------PKGSSSQNGETDVSEFSLVPCQ 342
C L ++ G C P S + EC G + T+ E C
Sbjct: 2053 CQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQICP 2112
Query: 343 NGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTE 402
G+ I +D S + D C+ + + C + Y C C G+
Sbjct: 2113 YGSGIIVGPDD-----SAVDMD--------ECKEPDVCKHGQCINTDGSYRCECPFGYIL 2159
Query: 403 KNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCG 462
E +D + N C N+IG F+ C G P +++ Q+ C
Sbjct: 2160 AGNE-CVDTDECSVGNPCGNGTCKNVIGGFECTCEEGFEPGPMMTCEDINECAQNPLLCA 2218
Query: 463 ---VTFHGICQDKGPAQF 477
V +G + K P +
Sbjct: 2219 FRCVNTYGSYECKCPVGY 2236
Score = 57.0 bits (136), Expect = 5e-08
Identities = 45/145 (31%), Positives = 62/145 (42%), Gaps = 14/145 (9%)
Query: 305 KRGICPNSSSAYTYECPKGSSSQ-NGET-DVSEFSLVPCQNGTDCIKISNDVMCICSPIF 362
+ G C + + EC KG GE DV E PC G +CI C C +
Sbjct: 461 QNGRCIPTPGSCRCECNKGFQLDLRGECIDVDECEKNPCAGG-ECINNQGSYTCQCRAGY 519
Query: 363 TDLL----CKSIQTSCESFPLRNNATCKKCEKDYPCSCISGF----TEKNCEKAIDHCKL 414
L C+ I ++ + NN C + + C C +GF KNCE +D C +
Sbjct: 520 QSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVTRDGKNCED-MDECSI 578
Query: 415 LSINCLNEEWCFNIIGRFKYVCIPG 439
++ CLN C N G FK +C PG
Sbjct: 579 RNM-CLN-GMCINEDGSFKCICKPG 601
Score = 56.2 bits (134), Expect = 9e-08
Identities = 65/262 (24%), Positives = 89/262 (33%), Gaps = 57/262 (21%)
Query: 202 CQPPFSGKYCQELDACSFKPCKNNGSCIN-KRENWDEQAYECVCHPPFT------GKNCS 254
C P +G++ + CS C N E C P F GK
Sbjct: 967 CTLPIAGRHRMDACCCSVGAAWGTEECEECPMRNTPEYEELCPRGPGFATKEITNGKPFF 1026
Query: 255 EIIGQCQ--PHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNS 312
+ I +C+ P +C HG C N T SF C CD SG + + C
Sbjct: 1027 KDINECKMIPSLCTHGKCRN-TIGSFKCRCD---SGFALDSEERNC-------------- 1068
Query: 313 SSAYTYECPKGSSSQNGETDVSEFSLVP--CQNGTDCIKISNDVMCICSPIFTD--LLCK 368
TD+ E + P C G C+ D C C + ++ K
Sbjct: 1069 ------------------TDIDECRISPDLCGRG-QCVNTPGDFECKCDEGYESGFMMMK 1109
Query: 369 SIQT--SCESFPLR-NNATCKKCEKDYPCSCISGFT-EKNCEKAID--HCKLLSINCLNE 422
+ C+ PL C E Y C C G N ID C+L + C N
Sbjct: 1110 NCMDIDECQRDPLLCRGGVCHNTEGSYRCECPPGHQLSPNISACIDINECELSAHLCPNG 1169
Query: 423 EWCFNIIGRFKYVCIPGCTKNP 444
C N+IG+++ C PG P
Sbjct: 1170 R-CVNLIGKYQCACNPGYHSTP 1190
Score = 55.5 bits (132), Expect = 1e-07
Identities = 56/211 (26%), Positives = 81/211 (38%), Gaps = 44/211 (20%)
Query: 257 IGQCQ--PHVCFHGNCSNITSNSFICEC----------------DEQFSGPFCEVSAKPC 298
I +C+ P VC +G C N+ SF CEC DE +GP C+ +A+
Sbjct: 1767 IDECREIPGVCENGVCINMVG-SFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNAE-- 1823
Query: 299 VSLLFWKRGICPNSSSAYTYECPKGS--SSQNGETDVSEFSLVP--CQNGTDCIKISNDV 354
C N++ +Y +C G +S D +E +P C +G CI
Sbjct: 1824 ----------CINTAGSYRCDCKPGYRFTSTGQCNDRNECQEIPNICSHG-QCIDTVGSF 1872
Query: 355 MCICSPIFT----DLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGF--TEKNCEKA 408
C+C F +C I CE N TC+ + C C GF + N
Sbjct: 1873 YCLCHTGFKTNDDQTMCLDIN-ECERDAC-GNGTCRNTIGSFNCRCNHGFILSHNNDCID 1930
Query: 409 IDHCKLLSINCLNEEWCFNIIGRFKYVCIPG 439
+D C + N C N +G F+ C G
Sbjct: 1931 VDECASGNGNLCRNGQCINTVGSFQCQCNEG 1961
Score = 53.9 bits (128), Expect = 4e-07
Identities = 58/209 (27%), Positives = 85/209 (40%), Gaps = 35/209 (16%)
Query: 174 CQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGK----YCQELDACSFKPCKNNGSCI 229
CQE CS HG+C+ S + C C F C +++ C C NG+C
Sbjct: 1853 CQEI--PNICS-HGQCIDTVGS--FYCLCHTGFKTNDDQTMCLDINECERDAC-GNGTCR 1906
Query: 230 NKRENWDEQAYECVCHPPFTGKNCSEIIG--QCQP---HVCFHGNCSNITSNSFICECDE 284
N + + C C+ F + ++ I +C ++C +G C N T SF C+C+E
Sbjct: 1907 NTIGS-----FNCRCNHGFILSHNNDCIDVDECASGNGNLCRNGQCIN-TVGSFQCQCNE 1960
Query: 285 QFSGPFCEVSAKPCVSL---LFWKR----GICPNSSSAYTYECPKGSSSQNGE-TDVSEF 336
+ + CV + L R G C N +Y CP G S QN + D+ E
Sbjct: 1961 GYE---VAPDGRTCVDINECLLEPRKCAPGTCQNLDGSYRCICPPGYSLQNEKCEDIDEC 2017
Query: 337 SLVP--CQNGTDCIKISNDVMCICSPIFT 363
P C GT C C+C F+
Sbjct: 2018 VEEPEICALGT-CSNTEGSFKCLCPEGFS 2045
Score = 50.8 bits (120), Expect = 4e-06
Identities = 69/271 (25%), Positives = 101/271 (37%), Gaps = 65/271 (23%)
Query: 159 CPLGLRLNV-----TVKQQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPF----SGK 209
CP G + V V C+E + C HG+C++ S Y C C PF +G
Sbjct: 2111 CPYGSGIIVGPDDSAVDMDECKEP---DVCK-HGQCINTDGS--YRCEC--PFGYILAGN 2162
Query: 210 YCQELDACSF-KPCKNNGSCINKRENWDEQAYECVCHPPFTG---KNCSEIIGQCQPHVC 265
C + D CS PC NG+C N +EC C F C +I Q +
Sbjct: 2163 ECVDTDECSVGNPC-GNGTCKNV-----IGGFECTCEEGFEPGPMMTCEDINECAQNPLL 2216
Query: 266 FHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSS 325
C N T S+ C+C P +L R +C + EC
Sbjct: 2217 CAFRCVN-TYGSYECKC--------------PVGYVLREDRRMCKDED-----EC----- 2251
Query: 326 SQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIF---TDLLCKSIQTSCESFP-LRN 381
+ G+ D +E + +C + MCIC P + D + C++ P +
Sbjct: 2252 -EEGKHDCTEKQM-------ECKNLIGTYMCICGPGYQRRPDGEGCVDENECQTKPGICE 2303
Query: 382 NATCKKCEKDYPCSCISGFT-EKNCEKAIDH 411
N C Y C C GFT N ++ +D+
Sbjct: 2304 NGRCLNTRGSYTCECNDGFTASPNQDECLDN 2334
Score = 47.8 bits (112), Expect = 3e-05
Identities = 69/325 (21%), Positives = 107/325 (32%), Gaps = 74/325 (22%)
Query: 174 CQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPF----SGKYCQELDACSFKPCKNNGSCI 229
CQE C G GKC++ S + C C + + C +++ C G+C
Sbjct: 1610 CQELPG--LCQG-GKCINTFGS--FQCRCPTGYYLNEDTRVCDDVNECETPGICGPGTCY 1664
Query: 230 NKRENWDEQAYECVCHPPFT----GKNCSEIIGQ------------CQPHVCFH------ 267
N N Y C+C P + G NC ++ C + F+
Sbjct: 1665 NTVGN-----YTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGELLFNMTKKMC 1719
Query: 268 --------------GNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLL-------FWKR 306
C +++ F C Q G ++ V + +
Sbjct: 1720 CCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGLPVDIDECREIPGVCEN 1779
Query: 307 GICPNSSSAYTYECPKGSSSQNGET---DVSEFSLVP-CQNGTDCIKISNDVMCICSP-- 360
G+C N ++ ECP G + D+ E P CQ +CI + C C P
Sbjct: 1780 GVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNAECINTAGSYRCDCKPGY 1839
Query: 361 IFTDLLCKSIQTSCESFP-LRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSIN- 418
FT + + C+ P + ++ C + C C +GF + D L IN
Sbjct: 1840 RFTSTGQCNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTND-----DQTMCLDINE 1894
Query: 419 ----CLNEEWCFNIIGRFKYVCIPG 439
C N IG F C G
Sbjct: 1895 CERDACGNGTCRNTIGSFNCRCNHG 1919
Score = 44.7 bits (104), Expect = 3e-04
Identities = 71/306 (23%), Positives = 111/306 (36%), Gaps = 62/306 (20%)
Query: 178 LSSEFCSGHGKCLSEAWSKTYSCHCQPPF----SGKYCQELDACSFKPCKNNGSCINKRE 233
L+S C +G+C + S + C C F K C+++D C PC N G C N
Sbjct: 771 LNSLLCD-NGQCRNTPGS--FVCTCPKGFIYKPDLKTCEDIDECESSPCIN-GVCKNSPG 826
Query: 234 NWD-EQAYECVCHPPFTGKNCSEII----------GQCQPHV--------CFHGNCSNIT 274
++ E + E P T C E I G+C+ ++ C +
Sbjct: 827 SFICECSSESTLDP--TKTICIETIKGTCWQTVIDGRCEININGATLKSQCCSSLGAAWG 884
Query: 275 SNSFICECDEQFSGPFCEVSAKPCVSL----LF---WKRGICPNSSSAYTYECPKGSSSQ 327
S +C+ D + + C + +F K G+C N+ ++ +CP G +
Sbjct: 885 SPCTLCQVDPICGKGYSRIKGTQCEDIDECEVFPGVCKNGLCVNTRGSFKCQCPSGMTLD 944
Query: 328 NGETDVSEFSLVPC---QNGTDCIKISNDVMCICSPIFTDLLCKSIQTS-----CESFPL 379
+ L C +C + I D C S+ + CE P+
Sbjct: 945 ATGRICLDIRLETCFLRYEDEEC------TLPIAGRHRMDACCCSVGAAWGTEECEECPM 998
Query: 380 RNNATCKKCEKDYPCSCISGFTEKNCE------KAIDHCKLLSINCLNEEWCFNIIGRFK 433
RN E + C GF K K I+ CK++ C + + C N IG FK
Sbjct: 999 RNTP-----EYEELCPRGPGFATKEITNGKPFFKDINECKMIPSLCTHGK-CRNTIGSFK 1052
Query: 434 YVCIPG 439
C G
Sbjct: 1053 CRCDSG 1058
Score = 40.4 bits (93), Expect = 0.005
Identities = 57/259 (22%), Positives = 83/259 (32%), Gaps = 73/259 (28%)
Query: 174 CQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRE 233
C+ S FCS C + SC + + C+ + C N GSC +
Sbjct: 85 CRHSCGDGFCSRPNMCTCPSGQIAPSCGSR---------SIQHCNIR-CMNGGSCSDDH- 133
Query: 234 NWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEV 293
C+C + G +C + + C+ G C + N C C F+GP CE
Sbjct: 134 --------CLCQKGYIGTHCGQPV--CESGCLNGGRC--VAPNR--CACTYGFTGPQCER 179
Query: 294 SAK--PCVSLLF-------------WKRGICPNSSSAYTYECPKGSSSQN---------- 328
+ PC +++ K C A+ + C + +
Sbjct: 180 DYRTGPCFTVISNQMCQGQLSGIVCTKTLCCATVGRAWGHPCEMCPAQPHPCRRGFIPNI 239
Query: 329 ---GETDVSEFSLVP--CQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNA 383
DV E +P CQ G +CI C C P L N
Sbjct: 240 RTGACQDVDECQAIPGLCQGG-NCINTVGSFECKC-PAGHKL----------------NE 281
Query: 384 TCKKCEKDYPCSCISGFTE 402
+KCE CS I G E
Sbjct: 282 VSQKCEDIDECSTIPGICE 300
Score = 37.4 bits (85), Expect = 0.041
Identities = 43/182 (23%), Positives = 63/182 (34%), Gaps = 40/182 (21%)
Query: 174 CQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQE-------LDACSFKPCKNNG 226
C + + C G+C++ C C F+G C+ S + C+
Sbjct: 145 CGQPVCESGCLNGGRCVAPN-----RCACTYGFTGPQCERDYRTGPCFTVISNQMCQGQL 199
Query: 227 S---------CINKRENWDEQAYECVCHP--------PFTGKNCSEIIGQCQ--PHVCFH 267
S C W C P P + + +CQ P +C
Sbjct: 200 SGIVCTKTLCCATVGRAWGHPCEMCPAQPHPCRRGFIPNIRTGACQDVDECQAIPGLCQG 259
Query: 268 GNCSNITSNSFICECDEQFSGPFCEVSAK-----PCVSLL-FWKRGICPNSSSAYTYECP 321
GNC N T SF C+C EVS K C ++ + G C N+ S+Y +CP
Sbjct: 260 GNCIN-TVGSFECKCPAGHK--LNEVSQKCEDIDECSTIPGICEGGECTNTVSSYFCKCP 316
Query: 322 KG 323
G
Sbjct: 317 PG 318
Score = 36.2 bits (82), Expect = 0.092
Identities = 24/88 (27%), Positives = 35/88 (39%), Gaps = 10/88 (11%)
Query: 320 CPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPL 379
CP G + + + + + C NG C +D C+C + C Q CES L
Sbjct: 102 CPSGQIAPSCGSRSIQHCNIRCMNGGSC----SDDHCLCQKGYIGTHCG--QPVCESGCL 155
Query: 380 RNNATCKKCEKDYPCSCISGFTEKNCEK 407
+C C+C GFT CE+
Sbjct: 156 NGG----RCVAPNRCACTYGFTGPQCER 179
Score = 33.5 bits (75), Expect = 0.60
Identities = 42/209 (20%), Positives = 65/209 (31%), Gaps = 39/209 (18%)
Query: 259 QCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTY 318
QC +C H S +C C P C + ++ G C +
Sbjct: 79 QCIVPICRHSCGDGFCSRPNMCTCPSGQIAPSCGSRSIQHCNIRCMNGGSCSDDHCL--- 135
Query: 319 ECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFP 378
C KG + V E C NG C+ + C C+ FT C+ + F
Sbjct: 136 -CQKGYIGTHCGQPVCESG---CLNGGRCVAPNR---CACTYGFTGPQCERDYRTGPCFT 188
Query: 379 LRNNATCK------KCEKDYPCSCISGFTEKNCE----------------------KAID 410
+ +N C+ C K C+ + CE + +D
Sbjct: 189 VISNQMCQGQLSGIVCTKTLCCATVGRAWGHPCEMCPAQPHPCRRGFIPNIRTGACQDVD 248
Query: 411 HCKLLSINCLNEEWCFNIIGRFKYVCIPG 439
C+ + C C N +G F+ C G
Sbjct: 249 ECQAIPGLCQGGN-CINTVGSFECKCPAG 276
>gi|45593147 EGF-like-domain, multiple 9 [Homo sapiens]
Length = 383
Score = 94.4 bits (233), Expect = 3e-19
Identities = 64/243 (26%), Positives = 92/243 (37%), Gaps = 28/243 (11%)
Query: 176 ESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENW 235
+ + ++ CS H + SC C P + G +C+ C P +G+C
Sbjct: 22 QPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCER---CVRMPGCQHGTC------- 71
Query: 236 DEQAYECVCHPPFTGKNCSEIIGQCQPHVCFH-------GNCSNITSNSFICECDEQFSG 288
Q ++C+CH + GK C + H+C G C + C C F G
Sbjct: 72 -HQPWQCICHSGWAGKFCDK-----DEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHG 125
Query: 289 PFCEVSAKPCVSLLFWKR--GICPNSSSA---YTYECPKGSSSQNGETDVSEFSLVPCQN 343
CE A PC R G C + +T C G E +V + + PC N
Sbjct: 126 RDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCAN 185
Query: 344 GTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEK 403
G C+ N C+C F C C S P + A C+ D+ C C SG+ K
Sbjct: 186 GATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGK 245
Query: 404 NCE 406
CE
Sbjct: 246 TCE 248
Score = 77.4 bits (189), Expect = 4e-14
Identities = 50/202 (24%), Positives = 85/202 (42%), Gaps = 11/202 (5%)
Query: 176 ESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELD--ACSFKPCKNNGSCINKRE 233
E L E C C + + C C ++GK+C + + + PC+N G C+
Sbjct: 53 EGLHCERCVRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGG 112
Query: 234 NWDEQAYECVCHPPFTGKNCSEIIGQCQP--HVCFHGN-CSNIT--SNSFICECDEQFSG 288
Y CVC P F G++C G C+ C +G C + + +F C C F G
Sbjct: 113 G----EYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVG 168
Query: 289 PFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCI 348
CEV+ C+ C + + ++ CP+G + + ++ + + PCQ G C
Sbjct: 169 ARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCR 228
Query: 349 KISNDVMCICSPIFTDLLCKSI 370
+D C+C + C+ +
Sbjct: 229 DRVHDFDCLCPSGYGGKTCELV 250
Score = 50.8 bits (120), Expect = 4e-06
Identities = 64/238 (26%), Positives = 86/238 (36%), Gaps = 52/238 (21%)
Query: 353 DVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHC 412
D C C P + L C+ C P + TC + + C C SG+ K C+K C
Sbjct: 43 DGSCRCDPGWEGLHCER----CVRMPGCQHGTC---HQPWQCICHSGWAGKFCDKDEHIC 95
Query: 413 KLLSINCLNEEWC-FNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGI-CQ 470
S C N C ++ G + VC+PG FHG C+
Sbjct: 96 TTQS-PCQNGGQCMYDGGGEYHCVCLPG-------------------------FHGRDCE 129
Query: 471 DK-GPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDP-EDNNSSCWFPH 528
K GP + Q G G +CQ D F L C +V E N C
Sbjct: 130 RKAGPCE-----QAGSPCRNGGQCQD--DQGFALNFTCRCLVGFVGARCEVNVDDCLM-- 180
Query: 529 EGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEIN 586
CANG +CL + + LC +AG N D CQ A C+D ++
Sbjct: 181 ----RPCANGATCL--DGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVH 232
Score = 44.7 bits (104), Expect = 3e-04
Identities = 21/76 (27%), Positives = 37/76 (48%), Gaps = 8/76 (10%)
Query: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQAYE 241
C+ CL +SC C F+G++C LD C+ +PC+ C ++ ++D
Sbjct: 183 CANGATCLDGI--NRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFD----- 235
Query: 242 CVCHPPFTGKNCSEII 257
C+C + GK C ++
Sbjct: 236 CLCPSGYGGKTCELVL 251
>gi|45545431 EGF-like-domain, multiple 9 [Homo sapiens]
Length = 383
Score = 94.4 bits (233), Expect = 3e-19
Identities = 64/243 (26%), Positives = 92/243 (37%), Gaps = 28/243 (11%)
Query: 176 ESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENW 235
+ + ++ CS H + SC C P + G +C+ C P +G+C
Sbjct: 22 QPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCER---CVRMPGCQHGTC------- 71
Query: 236 DEQAYECVCHPPFTGKNCSEIIGQCQPHVCFH-------GNCSNITSNSFICECDEQFSG 288
Q ++C+CH + GK C + H+C G C + C C F G
Sbjct: 72 -HQPWQCICHSGWAGKFCDK-----DEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHG 125
Query: 289 PFCEVSAKPCVSLLFWKR--GICPNSSSA---YTYECPKGSSSQNGETDVSEFSLVPCQN 343
CE A PC R G C + +T C G E +V + + PC N
Sbjct: 126 RDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCAN 185
Query: 344 GTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEK 403
G C+ N C+C F C C S P + A C+ D+ C C SG+ K
Sbjct: 186 GATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGK 245
Query: 404 NCE 406
CE
Sbjct: 246 TCE 248
Score = 77.4 bits (189), Expect = 4e-14
Identities = 50/202 (24%), Positives = 85/202 (42%), Gaps = 11/202 (5%)
Query: 176 ESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELD--ACSFKPCKNNGSCINKRE 233
E L E C C + + C C ++GK+C + + + PC+N G C+
Sbjct: 53 EGLHCERCVRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGG 112
Query: 234 NWDEQAYECVCHPPFTGKNCSEIIGQCQP--HVCFHGN-CSNIT--SNSFICECDEQFSG 288
Y CVC P F G++C G C+ C +G C + + +F C C F G
Sbjct: 113 G----EYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVG 168
Query: 289 PFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCI 348
CEV+ C+ C + + ++ CP+G + + ++ + + PCQ G C
Sbjct: 169 ARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCR 228
Query: 349 KISNDVMCICSPIFTDLLCKSI 370
+D C+C + C+ +
Sbjct: 229 DRVHDFDCLCPSGYGGKTCELV 250
Score = 50.8 bits (120), Expect = 4e-06
Identities = 64/238 (26%), Positives = 86/238 (36%), Gaps = 52/238 (21%)
Query: 353 DVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHC 412
D C C P + L C+ C P + TC + + C C SG+ K C+K C
Sbjct: 43 DGSCRCDPGWEGLHCER----CVRMPGCQHGTC---HQPWQCICHSGWAGKFCDKDEHIC 95
Query: 413 KLLSINCLNEEWC-FNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGI-CQ 470
S C N C ++ G + VC+PG FHG C+
Sbjct: 96 TTQS-PCQNGGQCMYDGGGEYHCVCLPG-------------------------FHGRDCE 129
Query: 471 DK-GPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDP-EDNNSSCWFPH 528
K GP + Q G G +CQ D F L C +V E N C
Sbjct: 130 RKAGPCE-----QAGSPCRNGGQCQD--DQGFALNFTCRCLVGFVGARCEVNVDDCLM-- 180
Query: 529 EGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEIN 586
CANG +CL + + LC +AG N D CQ A C+D ++
Sbjct: 181 ----RPCANGATCL--DGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVH 232
Score = 44.7 bits (104), Expect = 3e-04
Identities = 21/76 (27%), Positives = 37/76 (48%), Gaps = 8/76 (10%)
Query: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQAYE 241
C+ CL +SC C F+G++C LD C+ +PC+ C ++ ++D
Sbjct: 183 CANGATCLDGI--NRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFD----- 235
Query: 242 CVCHPPFTGKNCSEII 257
C+C + GK C ++
Sbjct: 236 CLCPSGYGGKTCELVL 251
>gi|46249414 latent transforming growth factor beta binding protein 1
isoform LTBP-1L [Homo sapiens]
Length = 1722
Score = 90.5 bits (223), Expect = 4e-18
Identities = 76/282 (26%), Positives = 116/282 (41%), Gaps = 30/282 (10%)
Query: 176 ESLSSEFCSGHGKCLSEAWSKTYSCH---CQPPFSGKYCQELDACSFKPCKNNGSCINKR 232
E L C+ +G C + S SCH + P K+C+++D C NG C N
Sbjct: 1042 ECLEPNVCA-NGDCSNLEGSYMCSCHKGYTRTP-DHKHCRDIDECQQGNLCVNGQCKN-- 1097
Query: 233 ENWDEQAYECVCHPPF---TGKNCSEIIGQCQ-PHVCFHGNCSNITSNSFICECDEQFS- 287
E ++ C C + K+ E I +CQ H+C HG C N T SF C CD+ +
Sbjct: 1098 ---TEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRN-TEGSFQCVCDQGYRA 1153
Query: 288 ---GPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGET--DVSEFSLVP-C 341
G CE + +RG C N++ +Y CP G + +T D++E C
Sbjct: 1154 SGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGLC 1213
Query: 342 QNGTDCIKISNDVMCICSPIFT----DLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCI 397
+C+ C+C F+ C+ I + ++ C + C C
Sbjct: 1214 GPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCY 1273
Query: 398 SGFTEKNCEKA---IDHCKLLSINCLNEEWCFNIIGRFKYVC 436
GF + ++ C+LLS C E +C N+ G F VC
Sbjct: 1274 QGFQAPQDGQGCVDVNECELLSGVC-GEAFCENVEGSFLCVC 1314
Score = 72.0 bits (175), Expect = 2e-12
Identities = 100/395 (25%), Positives = 150/395 (37%), Gaps = 81/395 (20%)
Query: 213 ELDACSFKP--CKNNGSCINKRENWDEQAYECVCHPPFT----GKNCSEIIGQCQ-PHVC 265
E++ C+ P C G CIN Y C+C+ + + C +I Q H+C
Sbjct: 874 EINECTVNPDIC-GAGHCINLPVR-----YTCICYEGYRFSEQQRKCVDIDECTQVQHLC 927
Query: 266 FHGNCSNITSNSFICECDEQF----SGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYE-C 320
G C N T SF+C C F G C + C+ G C N+ A+ E C
Sbjct: 928 SQGRCEN-TEGSFLCICPAGFMASEEGTNC-IDVDECLRPDVCGEGHCVNTVGAFRCEYC 985
Query: 321 PKG-SSSQNGETDVSEFSLVP--CQNGTDCIKISNDVMCI-CSPIFTDLLCKSIQTS-CE 375
G +Q G + + L P C + C+ C+ C+ F + + C
Sbjct: 986 DSGYRMTQRGRCEDIDECLNPSTCPD-EQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECL 1044
Query: 376 SFPLRNNATCKKCEKDYPCSCISGFT----EKNCEKAIDHCKLLSINCLNEEWCFNIIGR 431
+ N C E Y CSC G+T K+C + ID C+ ++ C+N + C N G
Sbjct: 1045 EPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHC-RDIDECQQGNL-CVNGQ-CKNTEGS 1101
Query: 432 FKYVCIPG----CTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGF-A 486
F+ C G K+ C + H+HLC HG C++ F+ V G+ A
Sbjct: 1102 FRCTCGQGYQLSAAKDQCEDIDECQ--HRHLC-----AHGQCRNT-EGSFQCVCDQGYRA 1153
Query: 487 GSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCSCLSEED 546
G+ C+ + + C ED K +C G C++
Sbjct: 1154 SGLGDHCEDINE--------CLED---------------------KSVCQRG-DCINTAG 1183
Query: 547 SQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVC 581
S Y C G +N T NEC+H +C
Sbjct: 1184 S--YDCTC---PDGFQLDDNKTCQDINECEHPGLC 1213
Score = 57.0 bits (136), Expect = 5e-08
Identities = 74/311 (23%), Positives = 104/311 (33%), Gaps = 56/311 (18%)
Query: 176 ESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFS---GKYCQELDACSFKP-CKNNGSCINK 231
E L + G C++ A S Y C C F K CQ+++ C C G C+N
Sbjct: 1165 ECLEDKSVCQRGDCINTAGS--YDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNT 1222
Query: 232 RENWDEQAYECVCHPPFT----GKNCSEIIGQCQPHVC-FHGNCSNITSNSFICECDEQF 286
E ++ CVC F+ G+ C +I VC HG C N T+ SF C C + F
Sbjct: 1223 -----EGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDN-TAGSFRCLCYQGF 1276
Query: 287 SGP----------FCEVSAKPCVSLLFWKRGICPNSSSAYTYECP---------KGSSSQ 327
P CE+ + C C N ++ C G
Sbjct: 1277 QAPQDGQGCVDVNECELLSGVC------GEAFCENVEGSFLCVCADENQEYSPMTGQCRS 1330
Query: 328 NGETDVSEFSLVPCQNGTDCIKISNDV-MC--ICSPIFTDLLCKSIQ-----TSCESFPL 379
TD+ P + +C ND +C + +P T C +CE FP
Sbjct: 1331 RTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPC 1390
Query: 380 RNNAT------CKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFK 433
T C K + P S K D C L +C N ++
Sbjct: 1391 PVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYE 1450
Query: 434 YVCIPGCTKNP 444
C G +P
Sbjct: 1451 CYCKQGTYYDP 1461
Score = 53.1 bits (126), Expect = 7e-07
Identities = 40/148 (27%), Positives = 65/148 (43%), Gaps = 20/148 (13%)
Query: 149 ITVMASGPSPCPLGLRLNVTVKQQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFS- 207
I S CP G +L+ Q E C G+CL+ S + C CQ FS
Sbjct: 1179 INTAGSYDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNTEGS--FHCVCQQGFSI 1236
Query: 208 ---GKYCQELDAC-SFKPCKNNGSCINKRENWDEQAYECVCH----PPFTGKNCSEIIGQ 259
G+ C+++D C + C ++G C N ++ C+C+ P G+ C + + +
Sbjct: 1237 SADGRTCEDIDECVNNTVCDSHGFCDN-----TAGSFRCLCYQGFQAPQDGQGCVD-VNE 1290
Query: 260 CQ--PHVCFHGNCSNITSNSFICECDEQ 285
C+ VC C N+ SF+C C ++
Sbjct: 1291 CELLSGVCGEAFCENV-EGSFLCVCADE 1317
Score = 39.3 bits (90), Expect = 0.011
Identities = 62/290 (21%), Positives = 99/290 (34%), Gaps = 59/290 (20%)
Query: 181 EFCSGHGKCLSEAWSKTYSCHCQPPFSGKY-------CQELDACSFKPCKNNGSCINKRE 233
E C +G CL+ Y C+C+ G Y C ++D C +G C+N
Sbjct: 1435 EICK-NGFCLNTR--PGYECYCK---QGTYYDPVKLQCFDMDECQDPSSCIDGQCVNT-- 1486
Query: 234 NWDEQAYECVCHPPF----TGKNC---SEIIGQCQPHVCFHGNCSNITSNSFICECDEQF 286
E +Y C C P + K C +E Q + + C S+ ++C
Sbjct: 1487 ---EGSYNCFCTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVC------ 1537
Query: 287 SGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQN--- 343
++P V C A+ +C D ++ +P
Sbjct: 1538 --------SRPLVGKQTTYTECCCLYGEAWGMQC--ALCPLKDSDDYAQLCNIPVTGRRQ 1587
Query: 344 --GTDC-IKISNDVMCICSPIFTD--LLCKSIQTSCESFPLRN---NATCKKCEKDYPCS 395
G D + S P F L + E + N N C + ++ Y C
Sbjct: 1588 PYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCD 1647
Query: 396 CISGF---TEKNCEKAIDHCKLLSIN---CLNEEWCFNIIGRFKYVCIPG 439
C G+ T K ++ C L+ C N + C N G +K +C+PG
Sbjct: 1648 CFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAK-CINTDGSYKCLCLPG 1696
Score = 34.7 bits (78), Expect = 0.27
Identities = 39/165 (23%), Positives = 62/165 (37%), Gaps = 35/165 (21%)
Query: 170 KQQFCQESLSSEFCSGHGKCLSEAWSKTYSCH-----CQPPF---SGKYCQELDACSFKP 221
KQ+ C ++ + + G KC +Y + C P + + +CQ+++ C +
Sbjct: 577 KQEDCCGTVGTSW--GFNKCQKCPKKPSYHGYNQMMECLPGYKRVNNTFCQDINECQLQG 634
Query: 222 CKNNGSCINKRENWDEQAYECVCH----PPFTGKNC-------SEIIGQCQPHV-----C 265
NG C+N +Y C C P T +C SE G C V C
Sbjct: 635 VCPNGECLNTM-----GSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGPCYRLVSSGRQC 689
Query: 266 FHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICP 310
H ++T C + + GP CE P + + ICP
Sbjct: 690 MHPLSVHLTKQLCCCSVGKAW-GPHCEKCPLPGTAAF---KEICP 730
Score = 32.7 bits (73), Expect = 1.0
Identities = 34/116 (29%), Positives = 41/116 (35%), Gaps = 27/116 (23%)
Query: 162 GLRLNVTVKQQFCQESLSSEFCSGHGKCLSEAWSKTY-SCHCQPPFSGKYCQELDACSFK 220
G RL V KQQ ++ C HG WSK S C P +C
Sbjct: 152 GSRLQVHQKQQLQGVNVCGGRCC-HG------WSKAPGSQRCTKP----------SC-VP 193
Query: 221 PCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSN 276
PC+N G C+ + CVC P GK C I Q F G S+
Sbjct: 194 PCQNGGMCLRPQL--------CVCKPGTKGKACETIAAQDTSSPVFGGQSPGAASS 241
Score = 30.4 bits (67), Expect = 5.0
Identities = 19/61 (31%), Positives = 28/61 (45%), Gaps = 4/61 (6%)
Query: 320 CPKGSSSQNGETDVSEFSLVP-CQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFP 378
C G S G ++ S VP CQNG C++ +C+C P C++I S P
Sbjct: 173 CCHGWSKAPGSQRCTKPSCVPPCQNGGMCLR---PQLCVCKPGTKGKACETIAAQDTSSP 229
Query: 379 L 379
+
Sbjct: 230 V 230
Score = 29.6 bits (65), Expect = 8.6
Identities = 17/53 (32%), Positives = 23/53 (43%), Gaps = 14/53 (26%)
Query: 207 SGKYCQELDACSFK------PCKNNGSCINKRENWDEQAYECVCHPPFTGKNC 253
+G L A +F+ PC N G C ++ + C C P FTGK C
Sbjct: 386 NGHAADTLTATNFRVVICHLPCMNGGQCSSRDK--------CQCPPNFTGKLC 430
>gi|46249412 latent transforming growth factor beta binding protein
1 isoform LTBP-1S [Homo sapiens]
Length = 1396
Score = 90.5 bits (223), Expect = 4e-18
Identities = 76/282 (26%), Positives = 116/282 (41%), Gaps = 30/282 (10%)
Query: 176 ESLSSEFCSGHGKCLSEAWSKTYSCH---CQPPFSGKYCQELDACSFKPCKNNGSCINKR 232
E L C+ +G C + S SCH + P K+C+++D C NG C N
Sbjct: 716 ECLEPNVCA-NGDCSNLEGSYMCSCHKGYTRTP-DHKHCRDIDECQQGNLCVNGQCKN-- 771
Query: 233 ENWDEQAYECVCHPPF---TGKNCSEIIGQCQ-PHVCFHGNCSNITSNSFICECDEQFS- 287
E ++ C C + K+ E I +CQ H+C HG C N T SF C CD+ +
Sbjct: 772 ---TEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRN-TEGSFQCVCDQGYRA 827
Query: 288 ---GPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGET--DVSEFSLVP-C 341
G CE + +RG C N++ +Y CP G + +T D++E C
Sbjct: 828 SGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGLC 887
Query: 342 QNGTDCIKISNDVMCICSPIFT----DLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCI 397
+C+ C+C F+ C+ I + ++ C + C C
Sbjct: 888 GPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCY 947
Query: 398 SGFTEKNCEKA---IDHCKLLSINCLNEEWCFNIIGRFKYVC 436
GF + ++ C+LLS C E +C N+ G F VC
Sbjct: 948 QGFQAPQDGQGCVDVNECELLSGVC-GEAFCENVEGSFLCVC 988
Score = 72.0 bits (175), Expect = 2e-12
Identities = 100/395 (25%), Positives = 150/395 (37%), Gaps = 81/395 (20%)
Query: 213 ELDACSFKP--CKNNGSCINKRENWDEQAYECVCHPPFT----GKNCSEIIGQCQ-PHVC 265
E++ C+ P C G CIN Y C+C+ + + C +I Q H+C
Sbjct: 548 EINECTVNPDIC-GAGHCINLPVR-----YTCICYEGYRFSEQQRKCVDIDECTQVQHLC 601
Query: 266 FHGNCSNITSNSFICECDEQF----SGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYE-C 320
G C N T SF+C C F G C + C+ G C N+ A+ E C
Sbjct: 602 SQGRCEN-TEGSFLCICPAGFMASEEGTNC-IDVDECLRPDVCGEGHCVNTVGAFRCEYC 659
Query: 321 PKG-SSSQNGETDVSEFSLVP--CQNGTDCIKISNDVMCI-CSPIFTDLLCKSIQTS-CE 375
G +Q G + + L P C + C+ C+ C+ F + + C
Sbjct: 660 DSGYRMTQRGRCEDIDECLNPSTCPD-EQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECL 718
Query: 376 SFPLRNNATCKKCEKDYPCSCISGFT----EKNCEKAIDHCKLLSINCLNEEWCFNIIGR 431
+ N C E Y CSC G+T K+C + ID C+ ++ C+N + C N G
Sbjct: 719 EPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHC-RDIDECQQGNL-CVNGQ-CKNTEGS 775
Query: 432 FKYVCIPG----CTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGF-A 486
F+ C G K+ C + H+HLC HG C++ F+ V G+ A
Sbjct: 776 FRCTCGQGYQLSAAKDQCEDIDECQ--HRHLC-----AHGQCRNT-EGSFQCVCDQGYRA 827
Query: 487 GSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCSCLSEED 546
G+ C+ + + C ED K +C G C++
Sbjct: 828 SGLGDHCEDINE--------CLED---------------------KSVCQRG-DCINTAG 857
Query: 547 SQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVC 581
S Y C G +N T NEC+H +C
Sbjct: 858 S--YDCTC---PDGFQLDDNKTCQDINECEHPGLC 887
Score = 57.0 bits (136), Expect = 5e-08
Identities = 74/311 (23%), Positives = 104/311 (33%), Gaps = 56/311 (18%)
Query: 176 ESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFS---GKYCQELDACSFKP-CKNNGSCINK 231
E L + G C++ A S Y C C F K CQ+++ C C G C+N
Sbjct: 839 ECLEDKSVCQRGDCINTAGS--YDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNT 896
Query: 232 RENWDEQAYECVCHPPFT----GKNCSEIIGQCQPHVC-FHGNCSNITSNSFICECDEQF 286
E ++ CVC F+ G+ C +I VC HG C N T+ SF C C + F
Sbjct: 897 -----EGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDN-TAGSFRCLCYQGF 950
Query: 287 SGP----------FCEVSAKPCVSLLFWKRGICPNSSSAYTYECP---------KGSSSQ 327
P CE+ + C C N ++ C G
Sbjct: 951 QAPQDGQGCVDVNECELLSGVC------GEAFCENVEGSFLCVCADENQEYSPMTGQCRS 1004
Query: 328 NGETDVSEFSLVPCQNGTDCIKISNDV-MC--ICSPIFTDLLCKSIQ-----TSCESFPL 379
TD+ P + +C ND +C + +P T C +CE FP
Sbjct: 1005 RTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPC 1064
Query: 380 RNNAT------CKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFK 433
T C K + P S K D C L +C N ++
Sbjct: 1065 PVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYE 1124
Query: 434 YVCIPGCTKNP 444
C G +P
Sbjct: 1125 CYCKQGTYYDP 1135
Score = 53.1 bits (126), Expect = 7e-07
Identities = 40/148 (27%), Positives = 65/148 (43%), Gaps = 20/148 (13%)
Query: 149 ITVMASGPSPCPLGLRLNVTVKQQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFS- 207
I S CP G +L+ Q E C G+CL+ S + C CQ FS
Sbjct: 853 INTAGSYDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNTEGS--FHCVCQQGFSI 910
Query: 208 ---GKYCQELDAC-SFKPCKNNGSCINKRENWDEQAYECVCH----PPFTGKNCSEIIGQ 259
G+ C+++D C + C ++G C N ++ C+C+ P G+ C + + +
Sbjct: 911 SADGRTCEDIDECVNNTVCDSHGFCDN-----TAGSFRCLCYQGFQAPQDGQGCVD-VNE 964
Query: 260 CQ--PHVCFHGNCSNITSNSFICECDEQ 285
C+ VC C N+ SF+C C ++
Sbjct: 965 CELLSGVCGEAFCENV-EGSFLCVCADE 991
Score = 39.3 bits (90), Expect = 0.011
Identities = 62/290 (21%), Positives = 99/290 (34%), Gaps = 59/290 (20%)
Query: 181 EFCSGHGKCLSEAWSKTYSCHCQPPFSGKY-------CQELDACSFKPCKNNGSCINKRE 233
E C +G CL+ Y C+C+ G Y C ++D C +G C+N
Sbjct: 1109 EICK-NGFCLNTR--PGYECYCK---QGTYYDPVKLQCFDMDECQDPSSCIDGQCVNT-- 1160
Query: 234 NWDEQAYECVCHPPF----TGKNC---SEIIGQCQPHVCFHGNCSNITSNSFICECDEQF 286
E +Y C C P + K C +E Q + + C S+ ++C
Sbjct: 1161 ---EGSYNCFCTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVC------ 1211
Query: 287 SGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQN--- 343
++P V C A+ +C D ++ +P
Sbjct: 1212 --------SRPLVGKQTTYTECCCLYGEAWGMQC--ALCPLKDSDDYAQLCNIPVTGRRQ 1261
Query: 344 --GTDC-IKISNDVMCICSPIFTD--LLCKSIQTSCESFPLRN---NATCKKCEKDYPCS 395
G D + S P F L + E + N N C + ++ Y C
Sbjct: 1262 PYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCD 1321
Query: 396 CISGF---TEKNCEKAIDHCKLLSIN---CLNEEWCFNIIGRFKYVCIPG 439
C G+ T K ++ C L+ C N + C N G +K +C+PG
Sbjct: 1322 CFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAK-CINTDGSYKCLCLPG 1370
Score = 34.7 bits (78), Expect = 0.27
Identities = 39/165 (23%), Positives = 62/165 (37%), Gaps = 35/165 (21%)
Query: 170 KQQFCQESLSSEFCSGHGKCLSEAWSKTYSCH-----CQPPF---SGKYCQELDACSFKP 221
KQ+ C ++ + + G KC +Y + C P + + +CQ+++ C +
Sbjct: 251 KQEDCCGTVGTSW--GFNKCQKCPKKPSYHGYNQMMECLPGYKRVNNTFCQDINECQLQG 308
Query: 222 CKNNGSCINKRENWDEQAYECVCH----PPFTGKNC-------SEIIGQCQPHV-----C 265
NG C+N +Y C C P T +C SE G C V C
Sbjct: 309 VCPNGECLNTM-----GSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGPCYRLVSSGRQC 363
Query: 266 FHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICP 310
H ++T C + + GP CE P + + ICP
Sbjct: 364 MHPLSVHLTKQLCCCSVGKAW-GPHCEKCPLPGTAAF---KEICP 404
Score = 29.6 bits (65), Expect = 8.6
Identities = 17/53 (32%), Positives = 23/53 (43%), Gaps = 14/53 (26%)
Query: 207 SGKYCQELDACSFK------PCKNNGSCINKRENWDEQAYECVCHPPFTGKNC 253
+G L A +F+ PC N G C ++ + C C P FTGK C
Sbjct: 60 NGHAADTLTATNFRVVICHLPCMNGGQCSSRDK--------CQCPPNFTGKLC 104
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 87.4 bits (215), Expect = 3e-17
Identities = 50/192 (26%), Positives = 79/192 (41%), Gaps = 21/192 (10%)
Query: 215 DACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNIT 274
D+C PC+N GSC+ + V + ++ II +P
Sbjct: 3804 DSCVHGPCQNGGSCLRRL---------AVSSVLKSRESLPVIIVANEP------------ 3842
Query: 275 SNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVS 334
F+C+C ++G +CE+ C+ G C N ++ CP G + + E D++
Sbjct: 3843 LQPFLCKCLPGYAGSWCEIDIDECLPSPCHSGGTCHNLVGGFSCSCPDGFTGRACERDIN 3902
Query: 335 EFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPC 394
E PC+NG C C+C +T +C+S CE P N +C+ Y C
Sbjct: 3903 ECLQSPCKNGAICQNFPGSFNCVCKTGYTGKMCESSVNYCECNPCFNGGSCQSGVDSYYC 3962
Query: 395 SCISGFTEKNCE 406
C G K+CE
Sbjct: 3963 HCPFGVFGKHCE 3974
Score = 73.2 bits (178), Expect = 7e-13
Identities = 37/127 (29%), Positives = 55/127 (43%), Gaps = 6/127 (4%)
Query: 198 YSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEI 256
+ C C P ++G +C+ ++D C PC + G+C N + C C FTG+ C
Sbjct: 3846 FLCKCLPGYAGSWCEIDIDECLPSPCHSGGTCHNL-----VGGFSCSCPDGFTGRACERD 3900
Query: 257 IGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAY 316
I +C C +G SF C C ++G CE S C + G C + +Y
Sbjct: 3901 INECLQSPCKNGAICQNFPGSFNCVCKTGYTGKMCESSVNYCECNPCFNGGSCQSGVDSY 3960
Query: 317 TYECPKG 323
CP G
Sbjct: 3961 YCHCPFG 3967
Score = 67.0 bits (162), Expect = 5e-11
Identities = 34/121 (28%), Positives = 58/121 (47%), Gaps = 7/121 (5%)
Query: 198 YSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEI 256
+SC C F+G+ C+ +++ C PCKN C N ++ CVC +TGK C
Sbjct: 3884 FSCSCPDGFTGRACERDINECLQSPCKNGAICQNF-----PGSFNCVCKTGYTGKMCESS 3938
Query: 257 IGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWK-RGICPNSSSA 315
+ C+ + CF+G +S+ C C G CE+++ L + + + PN++
Sbjct: 3939 VNYCECNPCFNGGSCQSGVDSYYCHCPFGVFGKHCELNSYGFEELSYMEFPSLDPNNNYI 3998
Query: 316 Y 316
Y
Sbjct: 3999 Y 3999
Score = 61.6 bits (148), Expect = 2e-09
Identities = 42/150 (28%), Positives = 56/150 (37%), Gaps = 31/150 (20%)
Query: 340 PCQNGTDCIK------------------ISND----VMCICSPIFTDLLCKSIQTSCESF 377
PCQNG C++ ++N+ +C C P + C+ C
Sbjct: 3810 PCQNGGSCLRRLAVSSVLKSRESLPVIIVANEPLQPFLCKCLPGYAGSWCEIDIDECLPS 3869
Query: 378 PLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCI 437
P + TC + CSC GFT + CE+ I+ C L C N C N G F VC
Sbjct: 3870 PCHSGGTCHNLVGGFSCSCPDGFTGRACERDINEC--LQSPCKNGAICQNFPGSFNCVCK 3927
Query: 438 PGCTKNPCWFLKNVYLIHQHLCYCGVTFHG 467
G T C N C C F+G
Sbjct: 3928 TGYTGKMCESSVN-------YCECNPCFNG 3950
Score = 59.7 bits (143), Expect = 8e-09
Identities = 27/95 (28%), Positives = 43/95 (45%)
Query: 319 ECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFP 378
+C G + E D+ E PC +G C + C C FT C+ C P
Sbjct: 3849 KCLPGYAGSWCEIDIDECLPSPCHSGGTCHNLVGGFSCSCPDGFTGRACERDINECLQSP 3908
Query: 379 LRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCK 413
+N A C+ + C C +G+T K CE ++++C+
Sbjct: 3909 CKNGAICQNFPGSFNCVCKTGYTGKMCESSVNYCE 3943
Score = 46.2 bits (108), Expect = 9e-05
Identities = 40/148 (27%), Positives = 59/148 (39%), Gaps = 38/148 (25%)
Query: 184 SGHGKCLSEAWSKTYSCHCQPPFSGKY---------------CQELDACSFKPCKNNGSC 228
+G C++ W S PFSGK+ C+ + C+ PC + C
Sbjct: 4360 AGFDGCIASMWYGGESL----PFSGKHSLASISKTDPSVKIGCRGPNICASNPCWGDLLC 4415
Query: 229 INKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHG-NCSNITSNSFICECDEQFS 287
IN+ W AY CV PP G C H C +G +C + F C C + +
Sbjct: 4416 INQ---W--YAYRCV--PP----------GDCASHPCQNGGSCEPGLHSGFTCSCPDSHT 4458
Query: 288 GPFCEVSAKPCVSLLFWKRGICPNSSSA 315
G CE+ C+ +L + +C S A
Sbjct: 4459 GRTCEM-VVACLGVLCPQGKVCKAGSPA 4485
Score = 38.5 bits (88), Expect = 0.019
Identities = 19/60 (31%), Positives = 33/60 (55%), Gaps = 10/60 (16%)
Query: 197 TYSCHCQPPFSGKYCQ-ELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPF--TGKNC 253
+++C C+ ++GK C+ ++ C PC N GSC + +++ CH PF GK+C
Sbjct: 3921 SFNCVCKTGYTGKMCESSVNYCECNPCFNGGSCQSGVDSY-------YCHCPFGVFGKHC 3973
Score = 33.5 bits (75), Expect = 0.60
Identities = 15/51 (29%), Positives = 23/51 (45%)
Query: 367 CKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSI 417
C ++ +C P ++ TC C C G T K CEK++ LS+
Sbjct: 4159 CPRLEGACTRSPCQHGGTCMDYWSWQQCHCKEGLTGKYCEKSVTPDTALSL 4209
Score = 32.3 bits (72), Expect = 1.3
Identities = 16/48 (33%), Positives = 26/48 (54%), Gaps = 6/48 (12%)
Query: 211 CQELD-ACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEII 257
C L+ AC+ PC++ G+C+ + W Q +C C TGK C + +
Sbjct: 4159 CPRLEGACTRSPCQHGGTCM---DYWSWQ--QCHCKEGLTGKYCEKSV 4201
Score = 32.0 bits (71), Expect = 1.7
Identities = 17/64 (26%), Positives = 28/64 (43%), Gaps = 9/64 (14%)
Query: 355 MCICSPIFTDLLCKSIQTS--------CESFPLRNNATCKK-CEKDYPCSCISGFTEKNC 405
+C +P + DLLC + + C S P +N +C+ + CSC T + C
Sbjct: 4403 ICASNPCWGDLLCINQWYAYRCVPPGDCASHPCQNGGSCEPGLHSGFTCSCPDSHTGRTC 4462
Query: 406 EKAI 409
E +
Sbjct: 4463 EMVV 4466
Score = 31.2 bits (69), Expect = 3.0
Identities = 16/55 (29%), Positives = 22/55 (40%)
Query: 253 CSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRG 307
C + G C C HG + C C E +G +CE S P +L +G
Sbjct: 4159 CPRLEGACTRSPCQHGGTCMDYWSWQQCHCKEGLTGKYCEKSVTPDTALSLEGKG 4213
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.137 0.464
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,483,047
Number of Sequences: 37866
Number of extensions: 1387617
Number of successful extensions: 6536
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 96
Number of HSP's successfully gapped in prelim test: 213
Number of HSP's that attempted gapping in prelim test: 3008
Number of HSP's gapped (non-prelim): 1514
length of query: 619
length of database: 18,247,518
effective HSP length: 108
effective length of query: 511
effective length of database: 14,157,990
effective search space: 7234732890
effective search space used: 7234732890
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.