Guide to the Human Genome
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Search of human proteins with 223941923

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|223941923 OTU domain containing 1 [Homo sapiens]
         (481 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|223941923 OTU domain containing 1 [Homo sapiens]                   997   0.0  
gi|33457350 OTU domain containing 5 isoform a [Homo sapiens]           72   1e-12
gi|209977021 OTU domain containing 5 isoform b [Homo sapiens]          69   9e-12
gi|209977019 OTU domain containing 5 isoform b [Homo sapiens]          69   9e-12
gi|163965366 nascent polypeptide-associated complex alpha subuni...    63   5e-10
gi|116256464 hypothetical protein LOC343990 [Homo sapiens]             62   2e-09
gi|149773456 hypothetical protein LOC643314 [Homo sapiens]             60   3e-09
gi|122937321 UNC homeobox [Homo sapiens]                               60   6e-09
gi|110349772 alpha 1 type I collagen preproprotein [Homo sapiens]      59   7e-09
gi|110832843 TBP-associated factor 4 [Homo sapiens]                    59   7e-09
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    59   1e-08
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    56   8e-08
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    56   8e-08
gi|209977067 OTU domain containing 5 isoform c [Homo sapiens]          55   1e-07
gi|55741677 SET domain containing 1A [Homo sapiens]                    54   2e-07
gi|149192871 OTU domain containing 3 [Homo sapiens]                    54   3e-07
gi|111118976 collagen, type II, alpha 1 isoform 1 precursor [Hom...    54   4e-07
gi|111118974 collagen, type II, alpha 1 isoform 2 precursor [Hom...    54   4e-07
gi|110556644 zinc finger protein, multitype 1 [Homo sapiens]           53   5e-07
gi|169211815 PREDICTED: keratin associated protein 4.6 [Homo sap...    52   9e-07
gi|222418647 mucin 7, secreted precursor [Homo sapiens]                52   2e-06
gi|222418649 mucin 7, secreted precursor [Homo sapiens]                52   2e-06
gi|222418645 mucin 7, secreted precursor [Homo sapiens]                52   2e-06
gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]             52   2e-06
gi|148237270 hypermethylated in cancer 1 isoform 2 [Homo sapiens]      51   2e-06
gi|61676186 hypermethylated in cancer 1 isoform 1 [Homo sapiens]       51   2e-06
gi|122937267 lemur tyrosine kinase 3 [Homo sapiens]                    51   2e-06
gi|62177127 myosin heavy chain Myr 8 [Homo sapiens]                    51   2e-06
gi|169217659 PREDICTED: similar to ectonucleotide pyrophosphatas...    51   3e-06
gi|169167316 PREDICTED: similar to ectonucleotide pyrophosphatas...    51   3e-06

>gi|223941923 OTU domain containing 1 [Homo sapiens]
          Length = 481

 Score =  997 bits (2578), Expect = 0.0
 Identities = 481/481 (100%), Positives = 481/481 (100%)

Query: 1   MQLYSSVCTHYPAGAPGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAE 60
           MQLYSSVCTHYPAGAPGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAE
Sbjct: 1   MQLYSSVCTHYPAGAPGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAE 60

Query: 61  HREAAAVPAAKMPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLPPHYTSTAQITVRALG 120
           HREAAAVPAAKMPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLPPHYTSTAQITVRALG
Sbjct: 61  HREAAAVPAAKMPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLPPHYTSTAQITVRALG 120

Query: 121 ADRLLLHGPDPVPGAAGSAAAPRGRCLLLAPAPAAPVPPRRGSSAWLLEELLRPDCPEPA 180
           ADRLLLHGPDPVPGAAGSAAAPRGRCLLLAPAPAAPVPPRRGSSAWLLEELLRPDCPEPA
Sbjct: 121 ADRLLLHGPDPVPGAAGSAAAPRGRCLLLAPAPAAPVPPRRGSSAWLLEELLRPDCPEPA 180

Query: 181 GLDATREGPDRNFRLSEHRQALAAAKHRGPAATPGSPDPGPGPWGEEHLAERGPRGWERG 240
           GLDATREGPDRNFRLSEHRQALAAAKHRGPAATPGSPDPGPGPWGEEHLAERGPRGWERG
Sbjct: 181 GLDATREGPDRNFRLSEHRQALAAAKHRGPAATPGSPDPGPGPWGEEHLAERGPRGWERG 240

Query: 241 GDRCDAPGGDAARRPDPEAEAPPAGSIEAAPSSAAEPVIVSRSDPRDEKLALYLAEVEKQ 300
           GDRCDAPGGDAARRPDPEAEAPPAGSIEAAPSSAAEPVIVSRSDPRDEKLALYLAEVEKQ
Sbjct: 241 GDRCDAPGGDAARRPDPEAEAPPAGSIEAAPSSAAEPVIVSRSDPRDEKLALYLAEVEKQ 300

Query: 301 DKYLRQRNKYRFHIIPDGNCLYRAVSKTVYGDQSLHRELREQTVHYIADHLDHFSPLIEG 360
           DKYLRQRNKYRFHIIPDGNCLYRAVSKTVYGDQSLHRELREQTVHYIADHLDHFSPLIEG
Sbjct: 301 DKYLRQRNKYRFHIIPDGNCLYRAVSKTVYGDQSLHRELREQTVHYIADHLDHFSPLIEG 360

Query: 361 DVGEFIIAAAQDGAWAGYPELLAMGQMLNVNIHLTTGGRLESPTVSTMIHYLGPEDSLRP 420
           DVGEFIIAAAQDGAWAGYPELLAMGQMLNVNIHLTTGGRLESPTVSTMIHYLGPEDSLRP
Sbjct: 361 DVGEFIIAAAQDGAWAGYPELLAMGQMLNVNIHLTTGGRLESPTVSTMIHYLGPEDSLRP 420

Query: 421 SIWLSWLSNGHYDAVFDHSYPNPEYDNWCKQTQVQRKRDEELAKSMAISLSKMYIEQNAC 480
           SIWLSWLSNGHYDAVFDHSYPNPEYDNWCKQTQVQRKRDEELAKSMAISLSKMYIEQNAC
Sbjct: 421 SIWLSWLSNGHYDAVFDHSYPNPEYDNWCKQTQVQRKRDEELAKSMAISLSKMYIEQNAC 480

Query: 481 S 481
           S
Sbjct: 481 S 481


>gi|33457350 OTU domain containing 5 isoform a [Homo sapiens]
          Length = 571

 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 67/240 (27%), Positives = 100/240 (41%), Gaps = 17/240 (7%)

Query: 210 PAATPGSPDPGPGPWGEEHLAERGPRGWERG-------GDRCDAPGGDAARRPDPEAEAP 262
           P   PG P  GPG       A  G  G   G       G  C  PG    RR  P   A 
Sbjct: 102 PCGGPGGPGGGPGDALGAAAAGVGAAGVVVGVGGAVGVGGCCSGPGHSKRRRQAPGVGAV 161

Query: 263 PAGSIEAAPSSAAEPVIVSRSDPRDEKLALYLAEVEKQDKYLRQ--RNKYRFHIIP---D 317
             GS E     A                A+  A VE+Q+ +  +  R+K  F I     D
Sbjct: 162 GGGSPEREEVGAGYNSEDEYEAAAARIEAMDPATVEQQEHWFEKALRDKKGFIIKQMKED 221

Query: 318 GNCLYRAVSKTVYGDQSLHRELREQTVHYIADHLDHFSPLIEGDVGEFIIAAAQDGAWAG 377
           G CL+RAV+  VYGDQ +H  +R+  + Y+  + D+FS  +  D   +I    ++     
Sbjct: 222 GACLFRAVADQVYGDQDMHEVVRKHCMDYLMKNADYFSNYVTEDFTTYINRKRKNNCHGN 281

Query: 378 YPELLAMGQMLN--VNIHLTTGGRLESPTVSTMIHYLGPEDSLRPSIWLSWLSNGHYDAV 435
           + E+ AM +M N  V ++  + G      ++T   + G   +    I +S+  N HY++V
Sbjct: 282 HIEMQAMAEMYNRPVEVYQYSTGTSAVEPINT---FHGIHQNEDEPIRVSYHRNIHYNSV 338


>gi|209977021 OTU domain containing 5 isoform b [Homo sapiens]
          Length = 566

 Score = 68.9 bits (167), Expect = 9e-12
 Identities = 65/238 (27%), Positives = 99/238 (41%), Gaps = 18/238 (7%)

Query: 210 PAATPGSPDPGPGPWGEEHLAERGPRGWERG-------GDRCDAPGGDAARRPDPEAEAP 262
           P   PG P  GPG       A  G  G   G       G  C  PG    RR  P   A 
Sbjct: 102 PCGGPGGPGGGPGDALGAAAAGVGAAGVVVGVGGAVGVGGCCSGPGHSKRRRQAPGVGAV 161

Query: 263 PAGSIEAAPSSAAEPVIVSRSDPRDEKLALYLAEVEKQDKYLRQ--RNKYRFHIIP---D 317
             GS E     A                A+  A VE+Q+ +  +  R+K  F I     D
Sbjct: 162 GGGSPEREEVGAGYNSEDEYEAAAARIEAMDPATVEQQEHWFEKALRDKKGFIIKQMKED 221

Query: 318 GNCLYRAVSKTVYGDQSLHRELREQTVHYIADHLDHFSPLIEGDVGEFIIAAAQDGAWAG 377
           G CL+RAV+  VYGDQ +H  +R+  + Y+  + D+FS  +  D   +I    ++     
Sbjct: 222 GACLFRAVADQVYGDQDMHEVVRKHCMDYLMKNADYFSNYVTEDFTTYINRKRKNNCHGN 281

Query: 378 YPELLAMGQMLNVNIHLTTGGRLESPTVSTMIHYLGPEDSLRPSIWLSWLSNGHYDAV 435
           + E+ AM +M N  + +    +  +  ++T   + G   +    I +S+  N HY++V
Sbjct: 282 HIEMQAMAEMYNRPVEVY---QYSTEPINT---FHGIHQNEDEPIRVSYHRNIHYNSV 333


>gi|209977019 OTU domain containing 5 isoform b [Homo sapiens]
          Length = 566

 Score = 68.9 bits (167), Expect = 9e-12
 Identities = 65/238 (27%), Positives = 99/238 (41%), Gaps = 18/238 (7%)

Query: 210 PAATPGSPDPGPGPWGEEHLAERGPRGWERG-------GDRCDAPGGDAARRPDPEAEAP 262
           P   PG P  GPG       A  G  G   G       G  C  PG    RR  P   A 
Sbjct: 102 PCGGPGGPGGGPGDALGAAAAGVGAAGVVVGVGGAVGVGGCCSGPGHSKRRRQAPGVGAV 161

Query: 263 PAGSIEAAPSSAAEPVIVSRSDPRDEKLALYLAEVEKQDKYLRQ--RNKYRFHIIP---D 317
             GS E     A                A+  A VE+Q+ +  +  R+K  F I     D
Sbjct: 162 GGGSPEREEVGAGYNSEDEYEAAAARIEAMDPATVEQQEHWFEKALRDKKGFIIKQMKED 221

Query: 318 GNCLYRAVSKTVYGDQSLHRELREQTVHYIADHLDHFSPLIEGDVGEFIIAAAQDGAWAG 377
           G CL+RAV+  VYGDQ +H  +R+  + Y+  + D+FS  +  D   +I    ++     
Sbjct: 222 GACLFRAVADQVYGDQDMHEVVRKHCMDYLMKNADYFSNYVTEDFTTYINRKRKNNCHGN 281

Query: 378 YPELLAMGQMLNVNIHLTTGGRLESPTVSTMIHYLGPEDSLRPSIWLSWLSNGHYDAV 435
           + E+ AM +M N  + +    +  +  ++T   + G   +    I +S+  N HY++V
Sbjct: 282 HIEMQAMAEMYNRPVEVY---QYSTEPINT---FHGIHQNEDEPIRVSYHRNIHYNSV 333


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 87/312 (27%), Positives = 107/312 (34%), Gaps = 49/312 (15%)

Query: 9    THYPAGAPGPTAAAPAPPA---AATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAA 65
            T  P GAP P A  P  P    AATPF      P AA     P + +  PAA    + A 
Sbjct: 1002 TPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAA----TPPSPKGSPAATPLPKGAP 1057

Query: 66   AVPAAKMPAFSSCFEVVSGAAAPASAAAGPPGASCKP--------PLPPHYTSTAQ---- 113
              PAA +P+        S   AP   AA PP     P        P+PP  T  +     
Sbjct: 1058 TTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGL 1117

Query: 114  ITVRALGADRLLLHGPDPVPGAAGSAAAPRGRCLLLAPAPAAP-----VPPRRGSSAWLL 168
             T    GA       P P P    +   P+G     A  P +P      PP +G+     
Sbjct: 1118 ATPPHKGAPTTPAATP-PSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPA 1176

Query: 169  EELLRPD----CPEPAGLDATREGPDRNFRLSEHRQALAAAKHRG----PAATPGSPDPG 220
                 P      P P G   T             +  LA    +G    PAATP SP  G
Sbjct: 1177 ATPPSPKGGLATPSPKGAPTTPAATP-----PSPKGGLATPSPKGAPTTPAATPPSPKGG 1231

Query: 221  ---PGPWGEEHLAERGPRGWERGGDRCDAPGGDAARRPDPEAEAPPA--GSIEAAP-SSA 274
               P P G        P    +GG     P G     P P A  PP+  G +   P   A
Sbjct: 1232 LATPSPKGAPTTPAATPPS-PKGGPATPPPKG----APTPPAATPPSLKGGLATPPHKGA 1286

Query: 275  AEPVIVSRSDPR 286
              P +V+   P+
Sbjct: 1287 PNPAVVTPPSPK 1298



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 71/274 (25%), Positives = 90/274 (32%), Gaps = 60/274 (21%)

Query: 12   PAGAPGPTAAAPAPPAAAT--------PFKVSLQPPGAAGAAPEPETGECQPAAAAEHRE 63
            P GAP P+A  P  P   T        P  V+L  P    A P P+        ++  ++
Sbjct: 861  PKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKK 920

Query: 64   AAAVPAAK-MPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLP-PHYTSTAQITVRALGA 121
            A A PA K +PA        S   AP   AA PP     P  P P +  T          
Sbjct: 921  ARATPAPKGIPASP------SPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAAT----- 969

Query: 122  DRLLLHGPDPVPGAAGSAAAPRGRCLLLAPAPAAPVPPRRGSSAWLLEELLRPDCPEPAG 181
                     P P    +  +P+G     AP P A  PP              P  P P G
Sbjct: 970  --------PPSPKGGPATPSPKG-----APTPPAATPPSPKGG---------PATPSPKG 1007

Query: 182  LDATREGPDRNFRLSEHRQALAAAKHRGPAATPGSPDPGPGPWGEEHLAERGPRGWERGG 241
                      + + S             PAATP SP   P        A   P+G     
Sbjct: 1008 APTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPA-------ATPLPKG----- 1055

Query: 242  DRCDAPGGDAARRPDPEAEAPPAGSIEAAPSSAA 275
                AP   AA  P P+   P   S++ AP+  A
Sbjct: 1056 ----APTTPAATLPSPKG-GPATPSLKGAPTPPA 1084



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 77/281 (27%), Positives = 100/281 (35%), Gaps = 45/281 (16%)

Query: 15   APGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAVPAAKMPA 74
            AP    A+P+P  A TP   +   P    A P P+     PAA     +    PA   P 
Sbjct: 926  APKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGG--PATPSPK 983

Query: 75   FSSCFEVVSGAAAPASAAAGP----PGASCKPP--LPPHYTSTAQITVRALGADRLLLHG 128
             +        AA P S   GP    P  +  PP   PP    +   T    GA       
Sbjct: 984  GAP----TPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAAT 1039

Query: 129  PDPVPGAAGSAAAPRGRCLLLAP-APAAPVP-PRRGSSAWLLEELLRPDC---PEPAGLD 183
            P    G+  +   P+G     AP  PAA +P P+ G +   L+    P     P P G  
Sbjct: 1040 PPSPKGSPAATPLPKG-----APTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGP 1094

Query: 184  ATREGPDRNFRLS----EHRQALAAAKHRGPAATPGSPDPGPGPWGEEHLAERGPRGWER 239
            AT          +      +  LA   H+G   TP +  P P    +  LA   P+G   
Sbjct: 1095 ATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSP----KGGLATPPPKG--- 1147

Query: 240  GGDRCDAPGGDAARRPDPE---AEAPPAGSIEAAPSSAAEP 277
                  AP   AA  P P+   A  PP G   A  + AA P
Sbjct: 1148 ------APTTPAATPPSPKGGLATPPPKG---APTTPAATP 1179



 Score = 38.1 bits (87), Expect = 0.018
 Identities = 77/304 (25%), Positives = 97/304 (31%), Gaps = 38/304 (12%)

Query: 12   PAGAPGPTAAAPAPPAAATPFKVSLQPPGAAG-AAPEPETGECQPAAAAEH--------- 61
            P GAP P A  P P    TP   +  P    G   P  + G   PAA   H         
Sbjct: 1329 PKGAPTPPAVTP-PSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPP 1387

Query: 62   --REAAAVPAAKMPAFSSCFEVVSGAAAPAS-----AAAGPPGASCKPP-LPPHYTSTAQ 113
              +   A+P+ K    S     +S   APA+      AA P      PP + P     A 
Sbjct: 1388 SPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAP 1447

Query: 114  ITVRALGADRLLLHGPDP-----VPGAAGSAAAPRGRCLLLAP--APAAPVPPRRGSSAW 166
             T    G         DP      P +     AP+      +P  APA P P      A 
Sbjct: 1448 ATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAP----MGAP 1503

Query: 167  LLEELLRPDCPEPAGLDATREGP--DRNFRLSEHRQALAAAKHR--GPAATPGSPDPGPG 222
             L  ++     E     ++R  P       LS+   A  A K     PA T  SP   P 
Sbjct: 1504 TLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPA 1563

Query: 223  -PWGEEHLAERGPRGWERGGDRCDAPGGDAARRPDPEAEAPPAGSIEAAPSSAAEPVIVS 281
             P  +E  A   P   E        P          E   PPA +   +P  A  P  V+
Sbjct: 1564 IPTPKE--APATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVT-SPSPKEAPTPPAVT 1620

Query: 282  RSDP 285
               P
Sbjct: 1621 PPSP 1624



 Score = 34.7 bits (78), Expect = 0.20
 Identities = 52/227 (22%), Positives = 68/227 (29%), Gaps = 47/227 (20%)

Query: 14   GAPGPTAAAPAPP----------AAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHRE 63
            GAP P    P  P           A TP   +   P  +   P P+     PA      +
Sbjct: 1285 GAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPK 1344

Query: 64   AAAVPAAKMPAFSSCFEVVSGAAAPASAAAGPP---GASCKPPLPPHYTSTAQITVRALG 120
                  A  P+        S    P   AA P    G +  PP P               
Sbjct: 1345 GTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPK-------------- 1390

Query: 121  ADRLLLHGPDPVPGAAGSAAAPRGRCLLLAPAPAAPVPPRRGSSAWLLEELLRPDCPEPA 180
                   GP  +P   G   +P    + L+P  A   P  R  +A   +  L P    P 
Sbjct: 1391 ------RGP-AIPSPKGDPTSP--AVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPV 1441

Query: 181  GLDATREGPDRNFRLSEHRQALAAAKHRG----PAATPGSPDPGPGP 223
             L   ++ P      S  +   A    +G    PA TP SP   P P
Sbjct: 1442 SL---KKAP----ATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAP 1481



 Score = 33.1 bits (74), Expect = 0.57
 Identities = 45/174 (25%), Positives = 69/174 (39%), Gaps = 29/174 (16%)

Query: 17   GPTA-----AAPAP---PAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAVP 68
            GPTA      APAP   P    P +   Q   ++  +P P   +      ++   +   P
Sbjct: 1677 GPTALKEVLVAPAPESTPIITAPTRKGPQTKKSSATSP-PICPDPSAKNGSKGPLSTVAP 1735

Query: 69   AAKMPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLPPHYTSTAQITVRALGADRLLLHG 128
            A  +P      +   G  A  S    P G    P  PP   ++  +T  A   +++L   
Sbjct: 1736 APLLPVQKDSSKTAKGKDASHS----PKG----PLAPPESKASTPLTAAAF--EKVL--- 1782

Query: 129  PDPVPGAAGSAAAPRGRCLL-LAPAPAAPVPPRR----GSSAWLLEELLRPDCP 177
              P P +A  +AAP     L LAP+P   +PP++     S   +LE   +P  P
Sbjct: 1783 --PKPESASVSAAPSPPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPSKPLAP 1834



 Score = 32.7 bits (73), Expect = 0.75
 Identities = 38/153 (24%), Positives = 56/153 (36%), Gaps = 12/153 (7%)

Query: 14  GAPGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAA--AEHREAAAVPAAK 71
           G PGPT   P  PA   P +  L     A   P P T    P      +     A+P   
Sbjct: 39  GQPGPTLPPPCSPA---PQQCPLSAANQASPFPSPSTIASTPLEVPFPQSSSGTALPLGT 95

Query: 72  MPAFSSCF-EVVSGAAAPASAAAGPPGASCKPPLPPHYTSTAQITVRAL---GADRLLLH 127
            P   +    ++    +PA+ A   P     P L    +S+A + + AL      +    
Sbjct: 96  APEAPTFLPNLIGPPISPAALALASP--MIAPTLKGTPSSSAPLALVALAPHSVQKSSAF 153

Query: 128 GPDPVPGAAGSAAAPRGRCLLLAPAPAAPVPPR 160
            P+ +      A A  G  + L+ AP AP  P+
Sbjct: 154 PPNLLTSPPSVAVAESGSVITLS-APIAPSEPK 185



 Score = 30.0 bits (66), Expect = 4.9
 Identities = 44/185 (23%), Positives = 63/185 (34%), Gaps = 71/185 (38%)

Query: 18   PTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAVPAAKMPAFSS 77
            P   +P+P  A TP          A   P PE G   PA                     
Sbjct: 1603 PAVTSPSPKEAPTP---------PAVTPPSPEKGPATPA--------------------- 1632

Query: 78   CFEVVSGAAAPASAAAGPPGASCKPPLPPHY-----TSTAQITVRALGADRLLLHGPDPV 132
                             P G    PP+ P       TS A +T + +GA          V
Sbjct: 1633 -----------------PKGTPTSPPVTPSSLKDSPTSPASVTCK-MGA---------TV 1665

Query: 133  PGAAGSAAAPRG----RCLLLAPAP-AAPV---PPRRGSSAWLLEELLRPDCPEPAGLDA 184
            P A+    A +G    + +L+APAP + P+   P R+G           P CP+P+  + 
Sbjct: 1666 PQASKGLPAKKGPTALKEVLVAPAPESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNG 1725

Query: 185  TREGP 189
            ++ GP
Sbjct: 1726 SK-GP 1729


>gi|116256464 hypothetical protein LOC343990 [Homo sapiens]
          Length = 962

 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 79/291 (27%), Positives = 104/291 (35%), Gaps = 41/291 (14%)

Query: 12  PAGAPGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPET-GECQPAAAAEHR------EA 64
           P+   GP  + P   A  TP  +  +  G  G APEPE   E +P   A         E 
Sbjct: 425 PSARDGPERSVPKE-AEPTPPVLPDEEKGPPGPAPEPEREAETEPERGAGTEPERIGTEP 483

Query: 65  AAVPAAKMPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLPPHYTSTAQITVRALGADRL 124
           +  PA   PA  SC +    AA+   AA+ P  A+  PP+ P                  
Sbjct: 484 STAPAPSPPAPKSCLKHRPAAASEGPAASPPLAAAESPPVEP------------------ 525

Query: 125 LLHGPDPVPGAAGSAAAPRGRCLLLAPAPAAPVPPRRGSSAWLLEELLRPDCPEPAGLDA 184
              GP  +   A +   P+       PA A    P R +     E          +    
Sbjct: 526 ---GPGSLDAEAAAPERPKAERAEAPPAGAERAAPERKAERGGAELRGAKKFSVSSCRAR 582

Query: 185 TREGPDRNFRLSEHRQALAAAKH--RGPAATP---GSPDPGPGPWGEEHLAERGPRGWER 239
            R G  R    +  R  LA +    R  AA     G P+P     G   LAERGP   + 
Sbjct: 583 PRPGVSRPLERASGRLPLARSGPVWRSEAALDDLQGLPEPQHAKPGPRKLAERGP---QD 639

Query: 240 GGDRCDAPGGDAARRPDPEAEAPPAGSIEAAPSSAAEPVIVSRSDPRDEKL 290
            GDR  +P G    R  P+  A   G+ E  P +A EP      +P   KL
Sbjct: 640 SGDRAASPAGP---RKSPQEAAAAPGTREPCP-AAQEPAPSEDRNPFPVKL 686



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 79/280 (28%), Positives = 95/280 (33%), Gaps = 60/280 (21%)

Query: 14  GAPGPTAAA-PAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAVPAAKM 72
           G PG   ++ PA P  A P       P      P P  G   P      ++  A PA   
Sbjct: 326 GVPGEDPSSRPATPELAEPESA----PTLRVEPPSPPEGPPNPGPDGGKQDGEAPPAGPC 381

Query: 73  -PAFSSCFEVVSGAAAPASA--AAGPPGASCKPPLPPHYTSTAQITVRALGADRLLLHGP 129
            PA     EVV      AS    A P G +  P   P  TS A       G +R +    
Sbjct: 382 APATDKAEEVVCAPEDVASPFPTAIPEGDTTPPETDPAATSEAPSARD--GPERSVPKEA 439

Query: 130 DPVPGAA-GSAAAPRGRCLLLAPAPA--APVPPRRGSSAWLLEELLRPDCPEPAGLD--- 183
           +P P         P G     AP P   A   P RG+             PE  G +   
Sbjct: 440 EPTPPVLPDEEKGPPGP----APEPEREAETEPERGAGTE----------PERIGTEPST 485

Query: 184 ATREGPDRNFRLSEHRQALAAAKHRGPAATPG-----SP--DPGPGPWGEEHLAERGPRG 236
           A    P       +HR A A+    GPAA+P      SP  +PGPG    E  A   P+ 
Sbjct: 486 APAPSPPAPKSCLKHRPAAAS---EGPAASPPLAAAESPPVEPGPGSLDAEAAAPERPKA 542

Query: 237 WERGGDRCDAPGGDAARRPDPEAEAPPAGSIEAAPSSAAE 276
                                 AEAPPAG+  AAP   AE
Sbjct: 543 --------------------ERAEAPPAGAERAAPERKAE 562



 Score = 35.4 bits (80), Expect = 0.12
 Identities = 51/192 (26%), Positives = 65/192 (33%), Gaps = 34/192 (17%)

Query: 13  AGAPG-----PTAAAPAPPAAATPFKVSLQPPGAA-----GAAPEPETGECQPAAAAEHR 62
           A APG     P A  PAP     PF V L+    +     GA+ E +  +   A     R
Sbjct: 658 AAAPGTREPCPAAQEPAPSEDRNPFPVKLRSTSLSLKYRDGASQEVKGVKRYSAEVRLER 717

Query: 63  EAAAVPAAKMPAFSSCFEVVSGAAAPASAAAG----PPGASCKPPLPPHYTSTAQITVRA 118
               +P  +     +    + G  AP+    G    P   S KPPLP           + 
Sbjct: 718 SLTVLPKEEKCPLGTA-PALRGTRAPSDQGKGKARPPEPLSSKPPLPR----------KP 766

Query: 119 LGADRLLLHGPDPVPGAAGSAAAPRGRCLLLAPAPAAPVPPRRGSSAWLLEELLRPDC-- 176
           L     L H P P P A      PR       P  A   P RRG+   L      P    
Sbjct: 767 LLQSFTLPHQPAP-PDAGPGEREPRKE-----PRTAEKRPLRRGAEKSLPPAATGPGADG 820

Query: 177 -PEPAGLDATRE 187
            P P  +  TR+
Sbjct: 821 QPAPPWITVTRQ 832



 Score = 34.7 bits (78), Expect = 0.20
 Identities = 51/177 (28%), Positives = 63/177 (35%), Gaps = 30/177 (16%)

Query: 6   SVCTHYPAGAP-GPTAAAPAPPAAATPFKV---SLQPPGAAGAAPEPETGECQPAAAAE- 60
           S   H PA A  GP A+ P   A + P +    SL    AA   P+ E  E  PA A   
Sbjct: 496 SCLKHRPAAASEGPAASPPLAAAESPPVEPGPGSLDAEAAAPERPKAERAEAPPAGAERA 555

Query: 61  ------HREAAAVPAAKMPAFSSCFEVVSGAAAPASAAAGP-PGASCKPPL----PPHYT 109
                  R  A +  AK  + SSC       A P    + P   AS + PL    P   +
Sbjct: 556 APERKAERGGAELRGAKKFSVSSC------RARPRPGVSRPLERASGRLPLARSGPVWRS 609

Query: 110 STAQITVRAL--------GADRLLLHGPDPVPGAAGSAAAPRGRCLLLAPAPAAPVP 158
             A   ++ L        G  +L   GP      A S A PR      A AP    P
Sbjct: 610 EAALDDLQGLPEPQHAKPGPRKLAERGPQDSGDRAASPAGPRKSPQEAAAAPGTREP 666



 Score = 30.4 bits (67), Expect = 3.7
 Identities = 44/162 (27%), Positives = 58/162 (35%), Gaps = 17/162 (10%)

Query: 124 LLLHGPDPVPGAAGSAAAP-RGRCLLLAPAPAAPVPP---RRGSSAWLLEELLRPDCPEP 179
           LL   P+  P +     AP RG      P P AP+PP    R   A L          E 
Sbjct: 269 LLEVSPEERPSSGQQDVAPDRGP----EPGPPAPLPPPGGARARRARLQHSSALTASVEE 324

Query: 180 AGLDATREGPDRNFRLSEHRQALAAAKHRGPAATPGSPDPGPGPWGEEHLAERGPRG--- 236
            G+    E P       E  +  +A   R    +P    P PGP G +   E  P G   
Sbjct: 325 GGVPG--EDPSSRPATPELAEPESAPTLRVEPPSPPEGPPNPGPDGGKQDGEAPPAGPCA 382

Query: 237 --WERGGDRCDAPGGDAARRPD--PEAEAPPAGSIEAAPSSA 274
              ++  +   AP   A+  P   PE +  P  +  AA S A
Sbjct: 383 PATDKAEEVVCAPEDVASPFPTAIPEGDTTPPETDPAATSEA 424


>gi|149773456 hypothetical protein LOC643314 [Homo sapiens]
          Length = 1427

 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 81/298 (27%), Positives = 101/298 (33%), Gaps = 41/298 (13%)

Query: 12   PAGAPGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAVPAAK 71
            PA A  PT   P  PAAA P       P AA   PE  T    PAAA    E    PAA 
Sbjct: 1042 PAAAV-PTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPT---SPAAAVPTPEEPTSPAAA 1097

Query: 72   MPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLPPHYTSTAQITVRALGADRLLLHGPDP 131
            +P           AA P       P A+   P  P   + A  T          +  P+ 
Sbjct: 1098 VPTPEE--PTSPAAAVPTPEEPASPAAAVPTPEEPASPAAAVPTPEEPAFPAPAVPTPEE 1155

Query: 132  VPGAAGSAAAPRGRCLLLAPAPAAPVPPRRGSSAWLLEELLRP-----DCPEPAGLDATR 186
               AA +   P       +PA A P P    S A ++  L  P       P PA + AT 
Sbjct: 1156 SASAAVAVPTPEESA---SPAAAVPTPAESASFAAVVATLEEPTSPAASVPTPAAMVATL 1212

Query: 187  E---GPDRNFRLSEHRQALAAA------------------KHRGPAATPGSPDPGPGPWG 225
            E    P  +   SE   +LAAA                  +    AA   +P+    P  
Sbjct: 1213 EEFTSPAASVPTSEEPASLAAAVSNPEEPTSPAAAVPTLEEPTSSAAAVLTPEELSSPAA 1272

Query: 226  EEHLAERGPRGWERGGDRCDAPGGDAARRPDPEAEAPPAGS-----IEAAPSSAAEPV 278
                 E  P          + P   AA  P PE  A PA S     + A P++A  P+
Sbjct: 1273 SVPTPEE-PASPAAAVSNLEEPASPAAAVPTPEVAAIPAASVPTPEVPAIPAAAVPPM 1329



 Score = 36.6 bits (83), Expect = 0.052
 Identities = 65/272 (23%), Positives = 88/272 (32%), Gaps = 18/272 (6%)

Query: 20   AAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPA-AAAEHREAAAVPAAKMPAFSSC 78
            AA  AP  A  P      P G A  A      E  PA AAA  +E  +  A   P +++ 
Sbjct: 899  AAVSAPERATVPAVTVSVPEGTAAVAAVSSPEETAPAVAAAITQEGMSAVAGFSPEWAA- 957

Query: 79   FEVVSGAAAPASAAAGP--PGASCKPPLPPHYTSTAQITVRALGADRLLLHGPDPVPGAA 136
              +            GP  P  +   P  P   +    T     +    +  P+     A
Sbjct: 958  LAITVPITEEDGTPEGPVTPATTVHAPEEPDTAAVRVSTPEEPASPAAAVPTPEEPTSPA 1017

Query: 137  GSAAAPRGRCLLLAPAPAAPVPPRRGSSAWLL---EELLRPDCPEPAGLDATREGPDRNF 193
             +   P       +PA A P P    S A  +   EE   P    P   + T   P    
Sbjct: 1018 AAVPTPEEP---TSPAAAVPPPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPT--SPAAAV 1072

Query: 194  RLSEHRQALAAA-----KHRGPAATPGSPDPGPGPWGEEHLAERGPRGWERGGDRCDAPG 248
               E   + AAA     +   PAA   +P+    P       E  P          + P 
Sbjct: 1073 PTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEE-PASPAAAVPTPEEPA 1131

Query: 249  GDAARRPDPEAEAPPAGSIEAAPSSAAEPVIV 280
              AA  P PE  A PA ++     SA+  V V
Sbjct: 1132 SPAAAVPTPEEPAFPAPAVPTPEESASAAVAV 1163



 Score = 36.2 bits (82), Expect = 0.068
 Identities = 37/136 (27%), Positives = 49/136 (36%), Gaps = 27/136 (19%)

Query: 18   PTAAAPAPPAAATPFKVSLQPPGA-AGAAPEPETGECQPAAAAEHREAAAVPAAKMPAFS 76
            PT   PA PAAA     +L+ P + A A P PE     PAA+    E  A+PAA +P   
Sbjct: 1275 PTPEEPASPAAAVS---NLEEPASPAAAVPTPEVAAI-PAASVPTPEVPAIPAAAVPPME 1330

Query: 77   SCFEV---------------VSGAAAPASAAAGPPGASCKPPLPPHYTSTAQITVRALGA 121
                +               +S    P    A   G   K  L        ++T      
Sbjct: 1331 EVSPIGVPFLGVSAHTDSVPISEEGTPVLEEASSTGMWIKEDLDSLVFGIKEVT------ 1384

Query: 122  DRLLLHGPDPVPGAAG 137
               +LHG  P+   AG
Sbjct: 1385 -STVLHGKVPLAATAG 1399


>gi|122937321 UNC homeobox [Homo sapiens]
          Length = 531

 Score = 59.7 bits (143), Expect = 6e-09
 Identities = 80/291 (27%), Positives = 102/291 (35%), Gaps = 52/291 (17%)

Query: 11  YPAGAPGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETG--------ECQP--AAAAE 60
           + +GA G   A P  P A      +  P   +GA P+P  G         C P  A AA 
Sbjct: 260 HASGAAGTAPAPPGEPPAPGTCDPAFYPSQRSGAGPQPRPGRPADKDAASCGPGAAVAAV 319

Query: 61  HREAAAVPAAKMPAFSSCF-----EVVSGAAAPASAAAGPPGASCKPPLPPHYTSTAQIT 115
            R AA +P A   +  S          + + A A+AAAG   A   P  P          
Sbjct: 320 ERGAAGLPKASPFSVESLLSDSPPRRKAASNAAAAAAAGLDFAPGLPCAPRTLIGKGHFL 379

Query: 116 VRALGADRLLLHGPDPVPGAAGSAAAPRGRCLLLAPAPAA-PVPPRRGSSAWLLEELLRP 174
           +  +      L     + G AG   AP+       PAPA  P PP + S           
Sbjct: 380 LYPITQPLGFLVPQAALKGGAGLEPAPKD----APPAPAVPPAPPAQASFGAF------- 428

Query: 175 DCPEPAGLDATREGPDRNFRLSEHRQALAAAKHRGPAATPGSPDPGPGPWGEEHLAERGP 234
               P G       PD  F          A +     A+PG+P P P P+ +   A    
Sbjct: 429 --SGPGG------APDSAF----------ARRSPDAVASPGAPAPAPAPFRDLASAAATE 470

Query: 235 RGWERGGDRCDAPGGDAARRPDPEAEAPPAGSIEAAPSSAAEPVIVSRSDP 285
            G   GGD  DA  G A   P P A +P  G     PS A EP      +P
Sbjct: 471 GG---GGDCADA--GTAGPAPPPPAPSPRPG--PRPPSPAEEPATCGVPEP 514


>gi|110349772 alpha 1 type I collagen preproprotein [Homo sapiens]
          Length = 1464

 Score = 59.3 bits (142), Expect = 7e-09
 Identities = 83/271 (30%), Positives = 96/271 (35%), Gaps = 51/271 (18%)

Query: 12   PAGAPGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAV---- 67
            P+G  GPT A  AP     P      PPG AG A  P   + QP A  E  +A A     
Sbjct: 786  PSGPAGPTGARGAPGDRGEP-----GPPGPAGFA-GPPGADGQPGAKGEPGDAGAKGDAG 839

Query: 68   ---PAAKMPAFSSCFEVVSGAAAPASAAAGPPGASCKPPL-----PPHYTSTAQITVRAL 119
               PA           V +  A  A  +AGPPGA+  P       PP  +  A       
Sbjct: 840  PPGPAGPAGPPGPIGNVGAPGAKGARGSAGPPGATGFPGAAGRVGPPGPSGNA------- 892

Query: 120  GADRLLLHGPDPVPGAAG--SAAAPRGRCLLLAPA--PAAPVPPRRGSSAWLLEELLRPD 175
                    GP   PG AG      PRG      PA  P    PP     A    E   P 
Sbjct: 893  --------GPPGPPGPAGKEGGKGPRGE---TGPAGRPGEVGPPGPPGPA---GEKGSPG 938

Query: 176  CPEPAGLDATREGPDRNFRLSEHRQALAAAKHRGPAATPGSPDPG--PGPWGEEHLA-ER 232
               PAG   T  GP     ++  R  +     RG    PG P P   PG  G    + ER
Sbjct: 939  ADGPAGAPGT-PGPQ---GIAGQRGVVGLPGQRGERGFPGLPGPSGEPGKQGPSGASGER 994

Query: 233  GPRGWERGGDRCDAPGGDAARRPDPEAEAPP 263
            GP G   G      P G++ R   P AE  P
Sbjct: 995  GPPG-PMGPPGLAGPPGESGREGAPGAEGSP 1024



 Score = 45.8 bits (107), Expect = 9e-05
 Identities = 72/262 (27%), Positives = 88/262 (33%), Gaps = 55/262 (20%)

Query: 12   PAGAPGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAVPAAK 71
            PAG PGP     AP A     + S  PPGA G       G   P   + +   A  P   
Sbjct: 846  PAGPPGPIGNVGAPGAKGA--RGSAGPPGATGF--PGAAGRVGPPGPSGN---AGPPGPP 898

Query: 72   MPAFSSCFEVVSGAAAPAS--AAAGPPGASCKPPLPPHYTSTAQITVRALGADRLLLHGP 129
             PA     +   G   PA      GPPG    PP P     +        GAD     GP
Sbjct: 899  GPAGKEGGKGPRGETGPAGRPGEVGPPG----PPGPAGEKGSP-------GAD-----GP 942

Query: 130  DPVPGAAGSAAAPRGRCLLLAPAPAAPVPPRRGSSAWLLEELLRPDCPEPAGLDATREGP 189
               PG  G    P+G   +        +P +RG   +       P  P P+G +  ++GP
Sbjct: 943  AGAPGTPG----PQG---IAGQRGVVGLPGQRGERGF-------PGLPGPSG-EPGKQGP 987

Query: 190  DRNFRLSEHRQALAAAKHRGPAATPGSPDPGPGPWGEEHLAERGPRGWERGGDRCDAPGG 249
                          A+  RGP    G P    GP GE      G  G E    R  +PG 
Sbjct: 988  S------------GASGERGPPGPMGPPGLA-GPPGES--GREGAPGAEGSPGRDGSPGA 1032

Query: 250  DAARRPDPEAEAPPAGSIEAAP 271
               R     A  P A     AP
Sbjct: 1033 KGDRGETGPAGPPGAPGAPGAP 1054



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 78/295 (26%), Positives = 93/295 (31%), Gaps = 51/295 (17%)

Query: 12  PAGAPGPTA-----AAPAPPAAATPFKVSLQP--------PGAAGAAPEP-ETGECQPAA 57
           P GAPGP         P  P A+ P      P         G AG    P E G   P  
Sbjct: 192 PPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQG 251

Query: 58  AAEHREAAAVPAAKMPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLPPHYTSTAQITVR 117
           A      A +P  K     S  +   G A       GP G   +P  P    +  Q+  R
Sbjct: 252 ARGLPGTAGLPGMKGHRGFSGLDGAKGDA-------GPAGPKGEPGSPGENGAPGQMGPR 304

Query: 118 ALGADRLLLHGPDPV--------------PGAAGSAAAPRGRCLLLAPAPAAPVPPRRGS 163
            L  +R     P P               PG  G A  P     + A   A P  PR   
Sbjct: 305 GLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGPRGSE 364

Query: 164 SAWLLEELLRPDCPEPAGLDATREGPDRNFRLSEHRQALAAAKHRGPAATPGSPDPGPGP 223
               +     P  P PAG      GP  N        A  A    G A  PG P    GP
Sbjct: 365 GPQGVRG--EPGPPGPAG----AAGPAGNPGADGQPGAKGANGAPGIAGAPGFPG-ARGP 417

Query: 224 WGEEHLAERGPRGWERGGDRCDAPG--GDAARRPDPEAEAPPAGSIEAAPSSAAE 276
            G +     GP G +       APG  GD   + +P     P G ++  P  A E
Sbjct: 418 SGPQ--GPGGPPGPKGNSGEPGAPGSKGDTGAKGEP----GPVG-VQGPPGPAGE 465



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 81/301 (26%), Positives = 98/301 (32%), Gaps = 57/301 (18%)

Query: 14  GAPGPTAAAPAPPAAATPFKVSLQPPGAAGAA-------PEPETGECQPAAAAEHREAAA 66
           G+PGP     +P  A  P +  L  PGA G         P+ +TG   PA          
Sbjct: 512 GSPGPAGPKGSPGEAGRPGEAGL--PGAKGLTGSPGSPGPDGKTGPPGPAGQDGRPGPPG 569

Query: 67  VPAAKMPAFSSCFEVVSGAAAPASAAA-----GPPGA-----------SCKPPLPPHYTS 110
            P A+  A    F    GAA     A      GPPGA           +  PP P     
Sbjct: 570 PPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAG 629

Query: 111 TAQITVRALGADRLLLHGPDPVPGAAGSAAAPRGRCLLLAPAPAAPVPPRRGSSAWLLEE 170
                  A       L GP   PG AG          L AP P+      RG   +  E 
Sbjct: 630 ERGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGA----RGERGFPGER 685

Query: 171 LLRPDCPEPAGLDATREGPDRNFRLSEHRQALAAAKHRGPAATPGSPDPGPGPWGEEHLA 230
            ++   P PAG       P  +               +G A  PG+P     P  +    
Sbjct: 686 GVQGP-PGPAGPRGANGAPGNDGA-------------KGDAGAPGAPGSQGAPGLQGMPG 731

Query: 231 ERGPRGWE-RGGDRCDA--------PGGDAAR-RPDPEAEAPPAGSI----EAAPSSAAE 276
           ERG  G     GDR DA        PG D  R    P     PAG+     E+ PS  A 
Sbjct: 732 ERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPPGPAGAPGDKGESGPSGPAG 791

Query: 277 P 277
           P
Sbjct: 792 P 792



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 75/284 (26%), Positives = 88/284 (30%), Gaps = 75/284 (26%)

Query: 14  GAPGPTAA--------APAPPAAATPFKVSLQPPGAAGAA-PEPETGECQPAAAAEHREA 64
           GAPGP  A        A  PP    P      PPG  GA   + E G   P  +   +  
Sbjct: 314 GAPGPAGARGNDGATGAAGPPGPTGP----AGPPGFPGAVGAKGEAGPQGPRGSEGPQGV 369

Query: 65  AAVPAAKMPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLPPHYTSTAQITVRALGADRL 124
              P    PA         GAA PA    G PGA  +P                 GA   
Sbjct: 370 RGEPGPPGPA---------GAAGPA----GNPGADGQP-----------------GAK-- 397

Query: 125 LLHGPDPVPGAAGSAAAPRGRCLLLAPAPAAPVPPRRGSSAWLLEELLRPDCPEPAGLDA 184
              G +  PG AG+   P  R       P  P  P+  S          P  P   G   
Sbjct: 398 ---GANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSG--------EPGAPGSKGDTG 446

Query: 185 TR--------EGPDRNFRLSEHRQALAAAKHRGPAATPGSPDP--GPG----PWGEEHLA 230
            +        +GP         R    A    GP   PG P    GPG    P  +    
Sbjct: 447 AKGEPGPVGVQGPPGPAGEEGKR---GARGEPGPTGLPGPPGERGGPGSRGFPGADGVAG 503

Query: 231 ERGPRGWERGGDRCDAPGGDAARRPDP-EAEAPPAGSIEAAPSS 273
            +GP G ERG      P G       P EA  P A  +  +P S
Sbjct: 504 PKGPAG-ERGSPGPAGPKGSPGEAGRPGEAGLPGAKGLTGSPGS 546



 Score = 38.9 bits (89), Expect = 0.010
 Identities = 79/285 (27%), Positives = 93/285 (32%), Gaps = 53/285 (18%)

Query: 12   PAGAPGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAVPAAK 71
            PAG PG     P PP  A         PGA G A  P  G   P   A  R    +P  +
Sbjct: 915  PAGRPGEVGP-PGPPGPAG----EKGSPGADGPAGAP--GTPGPQGIAGQRGVVGLPGQR 967

Query: 72   -------MPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLP-PHYTSTAQITVRALGADR 123
                   +P  S   E      + AS   GPPG    P L  P   S  +    A G+  
Sbjct: 968  GERGFPGLPGPSG--EPGKQGPSGASGERGPPGPMGPPGLAGPPGESGREGAPGAEGSP- 1024

Query: 124  LLLHGPDPVPGAAGSA-----AAPRGRCLLLAP-APAAPVPPRRGSSAWLLEELLRPDCP 177
                G D  PGA G       A P G     AP AP AP P      +    E       
Sbjct: 1025 ----GRDGSPGAKGDRGETGPAGPPG-----APGAPGAPGPVGPAGKSGDRGETGPAGPA 1075

Query: 178  EPAGLDATR-----EGPDRNFRLSEHRQALAAAKHRGPAATPGSPDPGPGPWGEEHLAER 232
             P G    R     +GP  +   +  +       HRG +   G P P PG  GE+     
Sbjct: 1076 GPVGPVGARGPAGPQGPRGDKGETGEQGDRGIKGHRGFSGLQGPPGP-PGSPGEQ----- 1129

Query: 233  GPRGWERGGDRCDAPGGDAARRPDPEAEAPPAGSIEAAPSSAAEP 277
            GP G         A G    R P   A AP    +   P     P
Sbjct: 1130 GPSG---------ASGPAGPRGPPGSAGAPGKDGLNGLPGPIGPP 1165


>gi|110832843 TBP-associated factor 4 [Homo sapiens]
          Length = 1085

 Score = 59.3 bits (142), Expect = 7e-09
 Identities = 76/279 (27%), Positives = 91/279 (32%), Gaps = 68/279 (24%)

Query: 3   LYSSVCTHYPAGAPGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPE-TGECQPAAAAEH 61
           L + V +  PAGA G   AAPA               GA GAAPEP   G  +P      
Sbjct: 58  LGNHVVSGSPAGAAGAGPAAPAE--------------GAPGAAPEPPPAGRARPGGGGPQ 103

Query: 62  REAAAVPAAKMPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLPPHYTSTAQITVRALGA 121
           R     P   +               PA  A  PP A  +PP      S A +   A  A
Sbjct: 104 RPGPPSPRRPL--------------VPAGPA--PPAAKLRPPPEGSAGSCAPVPAAAAVA 147

Query: 122 DRLLLHGPDPVPGAAGSAAAPRGRCLLLAPAPAAPVPPRRGSSAWLLEELLRPDCPEPAG 181
                 GP+P P      A P        P P     P  G           P   +PAG
Sbjct: 148 A-----GPEPAPAGPAKPAGPAALAARAGPGPGPGPGPGPG-----------PGPGKPAG 191

Query: 182 LDATREGPDRNFRLSEHRQALAAAK--HRGPAATPGSPDPG-PGPWGEEHLAERGPRGWE 238
             A +        L+ H  A  A    + GPAA    P P  PG   +            
Sbjct: 192 PGAAQTLNGSAALLNSHHAAAPAVSLVNNGPAALLPLPKPAAPGTVIQT----------- 240

Query: 239 RGGDRCDAPGGDAARRPDPEAEAPPAGSIEAAPSSAAEP 277
                   P   AA  P P A +PPA    AAP++A  P
Sbjct: 241 -------PPFVGAAAPPAPAAPSPPAAPAPAAPAAAPPP 272



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 88/298 (29%), Positives = 106/298 (35%), Gaps = 82/298 (27%)

Query: 14  GAPGP----TAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAVPA 69
           G P P      A PAPPAA       L+PP      PE   G C P  AA     AAV A
Sbjct: 106 GPPSPRRPLVPAGPAPPAA------KLRPP------PEGSAGSCAPVPAA-----AAVAA 148

Query: 70  AKMPAFSSCFEVVSGAAAPASAAAGP-------PGASCKPPLPP---------------H 107
              PA +   +    AA  A A  GP       PG     P  P               H
Sbjct: 149 GPEPAPAGPAKPAGPAALAARAGPGPGPGPGPGPGPGPGKPAGPGAAQTLNGSAALLNSH 208

Query: 108 YTSTAQITVRALGADRLLLHGPDPVPGAAGS---------AAAPRGRCLLLAPAPAAPVP 158
           + +   +++   G   LL   P P P A G+         AAAP        PAPAAP P
Sbjct: 209 HAAAPAVSLVNNGPAALL---PLPKPAAPGTVIQTPPFVGAAAP--------PAPAAPSP 257

Query: 159 PRRGSSAWLLEELLRPDCPEPAGLDATREGPDRNFRLSEHRQALAAAKHRGPAATPGSPD 218
           P   + A        P  P PA L      P      +      AAA++ G A    +P 
Sbjct: 258 PAAPAPA-APAAAPPPPPPAPATLARPPGHPAGPPTAAPAVPPPAAAQNGGSAGAAPAPA 316

Query: 219 PGPGPWGEEHLAERGPRGWERGGDRCDAPG-GDAARRPDPEAEA-PPAGSIEAAPSSA 274
           P  G          GP G          PG G AA  P P  +A  P   ++AAP +A
Sbjct: 317 PAAG----------GPAGVS------GQPGPGAAAAAPAPGVKAESPKRVVQAAPPAA 358



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 52/181 (28%), Positives = 66/181 (36%), Gaps = 18/181 (9%)

Query: 12  PAGAPGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAVPAAK 71
           P  AP P A A APP          +PPG     P        PAAA     A A PA  
Sbjct: 257 PPAAPAPAAPAAAPPPPPPAPATLARPPGHPAGPPTAAPAVPPPAAAQNGGSAGAAPAPA 316

Query: 72  MPAFSSCFEVVSGAAAPASAAAGP-PGASCKPP------LPPHYTSTAQITVRALGADRL 124
             A       VSG   P +AAA P PG   + P       PP   + A     +  A  +
Sbjct: 317 PAAGGPA--GVSGQPGPGAAAAAPAPGVKAESPKRVVQAAPPAAQTLAASGPASTAASMV 374

Query: 125 LLHGPDPVPGAAGSAAAPRGRCLLLAPAPAAPVPPRRGSSAWLLEELLRPDCPEPAGLDA 184
           +  GP         AA P        PAP  P    +G++  + + L R      +G+ A
Sbjct: 375 I--GPTMQGALPSPAAVP-------PPAPGTPTGLPKGAAGAVTQSLSRTPTATTSGIRA 425

Query: 185 T 185
           T
Sbjct: 426 T 426



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 74/261 (28%), Positives = 88/261 (33%), Gaps = 67/261 (25%)

Query: 8   CTHYPAGA-----PGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAA---- 58
           C   PA A     P P  A PA PA          P    G  P P  G  +PA      
Sbjct: 137 CAPVPAAAAVAAGPEPAPAGPAKPAGPAALAARAGPGPGPGPGPGPGPGPGKPAGPGAAQ 196

Query: 59  ----------AEHREAAAV------PAAKMP-----AFSSCFEV---VSGAAAPASAAAG 94
                     + H  A AV      PAA +P     A  +  +    V  AA PA AA  
Sbjct: 197 TLNGSAALLNSHHAAAPAVSLVNNGPAALLPLPKPAAPGTVIQTPPFVGAAAPPAPAAPS 256

Query: 95  PPG-------ASCKPPLPPHYTSTAQITVRALGADRLLLHGPDPVPGAAGSAAAPRGRCL 147
           PP        A+  PP PP   + A+      G        P   P     AAA  G   
Sbjct: 257 PPAAPAPAAPAAAPPPPPPAPATLARPPGHPAGP-------PTAAPAVPPPAAAQNGGSA 309

Query: 148 LLAPAPAAPVPPRRGSSAWLLEELLRPDCPEPAGLDAT------REGPDRNFRLS-EHRQ 200
             APAPA    P  G  A +  +      P P    A        E P R  + +    Q
Sbjct: 310 GAAPAPA----PAAGGPAGVSGQ------PGPGAAAAAPAPGVKAESPKRVVQAAPPAAQ 359

Query: 201 ALAAAKHRGPAATPGSPDPGP 221
            LAA+   GPA+T  S   GP
Sbjct: 360 TLAAS---GPASTAASMVIGP 377


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 84/296 (28%), Positives = 106/296 (35%), Gaps = 36/296 (12%)

Query: 16  PGPTAAAPAPPAAATPFKVSLQPPGAAG---AAPEPETGECQPAAAAEHREAAAVPAAKM 72
           P P   AP  P A+ P   S  PP  A    AAP  +     PA+      A   P A  
Sbjct: 669 PSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPP 728

Query: 73  PAFSSCFEVVSG--AAAPASAAAGPPGASCK---------PPLPPHYTSTAQITVRALGA 121
           P  +   +V     A+ P S +A PP              PP PP     + +      A
Sbjct: 729 PLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQA 788

Query: 122 DRLLLHGP---DPVPGAAGSAAAPRGRCLLLAPAPAAPVPPRRGS--SAWLLEELLRPDC 176
              L   P    P P A+    AP      L  +P A  PP+     +A LL+  + P  
Sbjct: 789 PPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQ--VPPSP 846

Query: 177 PEPAGLDATRE----GPDRNFRLSEHRQALAAAKHRGPAATPGSPDPGPGPWGEEHLAER 232
           P    L A R     GPD +        ALA      P+ +P S   GP   G    A  
Sbjct: 847 PASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATS 906

Query: 233 GP---RGWERGGDRCDAPGGDAARRPDPEAEAPPAGSIEAAPSSAAEPVIVSRSDP 285
            P   RG++ G      P G AA  P P+AE   A    AA S    P +  R  P
Sbjct: 907 TPEELRGYDSG------PEGGAAASPPPDAEL--AACHPAAWSRGPAPPLAFRGAP 954



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 77/298 (25%), Positives = 100/298 (33%), Gaps = 62/298 (20%)

Query: 12   PAGAPGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAVPAAK 71
            P  A  P    P+PPA+     ++  PP            +  PA A    +A   P A 
Sbjct: 759  PLLAAPPLQVPPSPPASLPMSPLAKPPP------------QAPPALATPPLQALPSPPAS 806

Query: 72   MPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLPPHYTS-TAQITVRALGADRLLLHGPD 130
             P  +        A+ P S  A PP     P  PP   +   Q+      +  L      
Sbjct: 807  FPGQA---PFSPSASLPMSPLATPP-----PQAPPVLAAPLLQVPPSPPASPTLQAPRRP 858

Query: 131  PVPGAAGSAAAPRGRCLLLAPAPAAPVPPRRGSSAWL----LEELLRPDCPEPAGLDATR 186
            P PG   S + PR   L LA AP  P PP R  S+ L    L          P  L    
Sbjct: 859  PTPGPDTSVSGPR---LTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYD 915

Query: 187  EGPDRNFRLSEHRQALAAAKH-----RGPA------ATPGSPDPGP---GPWGEEHLA-- 230
             GP+     S    A  AA H     RGPA        PG+P P P   GP   + L   
Sbjct: 916  SGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTI 975

Query: 231  ----------------ERGPRGWERGGDRCDAPGGDAARRPDPEAEAP--PAGSIEAA 270
                            + GP     GG      G  A+ R   +A     P G+++A+
Sbjct: 976  YETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQAS 1033



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 58/210 (27%), Positives = 79/210 (37%), Gaps = 27/210 (12%)

Query: 15  APGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAVPAAKMPA 74
           A G     P P  +A P   +  P  +  +A E  T E  PAA    R  +A    + PA
Sbjct: 182 AAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAA---RRRPSAGGGLQRPA 238

Query: 75  FSSCFEVVSGAAAP-ASAAAGPPGASCKPPLPPHYTSTAQITVRALGADRLLLHGPDPVP 133
             S    +S +A P +S A   P A   P  P H +      ++AL   ++     D  P
Sbjct: 239 SRS----LSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAP 294

Query: 134 GAAGSAAAPRGRCLLLAPAP----AAPVPPRRGSSAWLLEELLRPDCPEPAGLDATREGP 189
                +++P     L  P+P    A PVPP   ++A  L   L P  P    L      P
Sbjct: 295 ALGPLSSSP-----LATPSPSGTKARPVPP-PDNAATPLPATLPPSPPLATPLPLAPPSP 348

Query: 190 DRNFRLSEHRQALAAAKHRGPAATPGSPDP 219
                L    Q L +     P ATP S  P
Sbjct: 349 SAPPSL----QTLPS-----PPATPPSQAP 369



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 72/300 (24%), Positives = 97/300 (32%), Gaps = 67/300 (22%)

Query: 22  APAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAA-----------------AEHREA 64
           +P+ PA+  P    LQ P +  A+P  +T    PA +                 A H   
Sbjct: 443 SPSRPASTPPDSPPLQAPLSLPASPPLQT-SLSPAVSPLSSPLTIHPLQALSSLASHSPQ 501

Query: 65  AAVPAAKMPAFSSCFEVVSGAAAPASAAAGPPGASCKPPL--------PPHYTSTAQITV 116
           A + +  MP      E  S  A P+     PP +   PPL        PP  T++A +T 
Sbjct: 502 APLSSLIMPP----LETQSSLAPPSLQT--PPASLTTPPLENLPSLAPPPLQTASAPLTT 555

Query: 117 RALGADRLLLHGPDPVPGAAGSAAAPRGRCLLLAPAPAAP----VPPRRGSSAWLLEELL 172
             L         P   P +  +   P     +  P P AP     PP +G  +  L  L 
Sbjct: 556 PHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLA 615

Query: 173 RPDCPEPAGLDATREGPDRNFRLSEHRQALAAAKHRGPAA-------TPGSPDPGPGPWG 225
            P    P  L         +   S     LA    + P A        P SP P P    
Sbjct: 616 TPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSP---- 671

Query: 226 EEHLAERGPRGWERGGDRCDAPGGDAARRPDPEAEAPPAGSIEAAPSSAAEPVIVSRSDP 285
                               AP    A  P   +  PP+   +A PS AA P+ V  S P
Sbjct: 672 -----------------PVQAPFSPPASPPVSPSATPPS---QAPPSLAAPPLQVPPSPP 711



 Score = 36.6 bits (83), Expect = 0.052
 Identities = 66/270 (24%), Positives = 86/270 (31%), Gaps = 58/270 (21%)

Query: 21  AAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAVPAAKMPAFSSCFE 80
           AA   PAA  P  ++ +PPG+    P        P   A  R   A  A      +    
Sbjct: 12  AAARTPAARAPGLLTPRPPGSPRPPP--------PVTPAALRVLGAAGAVGRKPLAERAG 63

Query: 81  VVSGAAAPASA-AAGP---PGASCKPPLPPHYTSTAQITVRALGADRLLLHGPDPVPGAA 136
            + GA  P SA  AGP    G S + P      S    + R   A       P PV    
Sbjct: 64  GIGGATIPESAPRAGPTRSAGTSSRNP-----ASRPPASGRGERAPPAKNTSPGPVSSPG 118

Query: 137 GSAAAPRGRCLLLAPAPAAPVPPRRGSSAWLLEELLRPDCPEPAGLDATREGPDRNFRLS 196
            ++   R       P P             L ++ LR    E        E P R+    
Sbjct: 119 RASGTTR-------PGP-------------LGQKGLRISAEETVARGKATEAPKRS---- 154

Query: 197 EHRQALAAAKHRGPAA-TPGSPDPGPGPWGEEHLAERGPRGWERGGDRCDAPGGDAARRP 255
               AL+A   R  +  TPG+P P         +A R        G     P    + RP
Sbjct: 155 ----ALSAGARRDTSGPTPGTPSPA--------MARRS----RAAGTEVGLPRPAPSARP 198

Query: 256 DPEAEAPPAGSIEAAPSSAAEPVIVSRSDP 285
            P  E P      A+  S  EP   +R  P
Sbjct: 199 RPPTEGPRKSVSSASEHSTTEPSPAARRRP 228


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 855

 Score = 55.8 bits (133), Expect = 8e-08
 Identities = 89/312 (28%), Positives = 109/312 (34%), Gaps = 62/312 (19%)

Query: 12  PAGAPGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAV---- 67
           PA A  P  A P+PPA+         PP +  A P P+     P A A H   A      
Sbjct: 398 PALALPPLQAPPSPPAS---------PPLSPLATPSPQA----PNALAVHLLQAPFSPPP 444

Query: 68  -PAAKMPAFSSCFEVVSGAAAPASAAAG---------PPGASCKPPLPPHYTSTAQITVR 117
            P  + P        VS +A P S A           PP     PP+ P  T   Q    
Sbjct: 445 SPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQ-APP 503

Query: 118 ALGADRLLLHGPD---------------PVPGAAGSAAAPRGRCLLLAPAPAAPVPPRRG 162
            L A  L L  P                P P A+    AP      L  +P A  PP+  
Sbjct: 504 PLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAP 563

Query: 163 S--SAWLLEELLRPDCPEPAGLDATRE----GPDRNFRLSEHRQALAAAKHRGPAATPGS 216
              +A LL+  + P  P    L A R     GPD +        ALA      P+ +P S
Sbjct: 564 PVLAAPLLQ--VPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSS 621

Query: 217 PDPGPGPWGEEHLAERGP---RGWERGGDRCDAPGGDAARRPDPEAEAPPAGSIEAAPSS 273
              GP   G    A   P   RG++ G      P G AA  P P+AE   A    AA S 
Sbjct: 622 TLSGPDLAGHSSSATSTPEELRGYDSG------PEGGAAASPPPDAEL--AACHPAAWSR 673

Query: 274 AAEPVIVSRSDP 285
              P +  R  P
Sbjct: 674 GPAPPLAFRGAP 685



 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 79/298 (26%), Positives = 102/298 (34%), Gaps = 65/298 (21%)

Query: 12  PAGAPGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAVPAAK 71
           P+  P P A    PP AA P +++  PP            +  PA A    +A   P A 
Sbjct: 493 PSATPPPQAP---PPLAAPPLQLAKPPP------------QAPPALATPPLQALPSPPAS 537

Query: 72  MPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLPPHYTS-TAQITVRALGADRLLLHGPD 130
            P  +        A+ P S  A PP     P  PP   +   Q+      +  L      
Sbjct: 538 FPGQA---PFSPSASLPMSPLATPP-----PQAPPVLAAPLLQVPPSPPASPTLQAPRRP 589

Query: 131 PVPGAAGSAAAPRGRCLLLAPAPAAPVPPRRGSSAWL----LEELLRPDCPEPAGLDATR 186
           P PG   S + PR   L LA AP  P PP R  S+ L    L          P  L    
Sbjct: 590 PTPGPDTSVSGPR---LTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYD 646

Query: 187 EGPDRNFRLSEHRQALAAAKH-----RGPA------ATPGSPDPGP---GPWGEEHLA-- 230
            GP+     S    A  AA H     RGPA        PG+P P P   GP   + L   
Sbjct: 647 SGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTI 706

Query: 231 ----------------ERGPRGWERGGDRCDAPGGDAARRPDPEAEAP--PAGSIEAA 270
                           + GP     GG      G  A+ R   +A     P G+++A+
Sbjct: 707 YETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQAS 764



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 80/315 (25%), Positives = 100/315 (31%), Gaps = 54/315 (17%)

Query: 15  APGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAVPAAKMPA 74
           A G     P P  +A P   +  P  +  +A E  T E  PAA         +      +
Sbjct: 182 AAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRS 241

Query: 75  FSSCFEVVSGAAAPASAAAGPPGASCKPP----------LPPHYTSTAQITVRALGADRL 124
            SS    +S  A    +A G P A   P            PP  T   +    ALG    
Sbjct: 242 LSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGP--- 298

Query: 125 LLHGP--DPVPGAAGSAAAPRG----------RCLLLAPAPAAPVPPRRGSSAWLLEELL 172
           L   P   P P AA  + AP             C L  P P AP  P    S   L+ L 
Sbjct: 299 LSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPS---LQTLP 355

Query: 173 RPDCPEPAGLDATREGP----DRNFRLSEHRQALAA---------------AKHRGPAAT 213
            P    P+    +   P      +F  S     LA                A    PA+ 
Sbjct: 356 SPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASP 415

Query: 214 PGSPDPGPGPWGEEHLAE---RGPRGWERGGDRCDAPGGDAARRPDPEAEAPPAGSIEAA 270
           P SP   P P     LA    + P           AP    A  P   +  PP+   +A 
Sbjct: 416 PLSPLATPSPQAPNALAVHLLQAPFS-PPPSPPVQAPFSPPASPPVSPSATPPS---QAP 471

Query: 271 PSSAAEPVIVSRSDP 285
           PS AA P+ V  S P
Sbjct: 472 PSLAAPPLQVPPSPP 486



 Score = 36.6 bits (83), Expect = 0.052
 Identities = 66/270 (24%), Positives = 86/270 (31%), Gaps = 58/270 (21%)

Query: 21  AAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAVPAAKMPAFSSCFE 80
           AA   PAA  P  ++ +PPG+    P        P   A  R   A  A      +    
Sbjct: 12  AAARTPAARAPGLLTPRPPGSPRPPP--------PVTPAALRVLGAAGAVGRKPLAERAG 63

Query: 81  VVSGAAAPASA-AAGP---PGASCKPPLPPHYTSTAQITVRALGADRLLLHGPDPVPGAA 136
            + GA  P SA  AGP    G S + P      S    + R   A       P PV    
Sbjct: 64  GIGGATIPESAPRAGPTRSAGTSSRNP-----ASRPPASGRGERAPPAKNTSPGPVSSPG 118

Query: 137 GSAAAPRGRCLLLAPAPAAPVPPRRGSSAWLLEELLRPDCPEPAGLDATREGPDRNFRLS 196
            ++   R       P P             L ++ LR    E        E P R+    
Sbjct: 119 RASGTTR-------PGP-------------LGQKGLRISAEETVARGKATEAPKRS---- 154

Query: 197 EHRQALAAAKHRGPAA-TPGSPDPGPGPWGEEHLAERGPRGWERGGDRCDAPGGDAARRP 255
               AL+A   R  +  TPG+P P         +A R        G     P    + RP
Sbjct: 155 ----ALSAGARRDTSGPTPGTPSPA--------MARRS----RAAGTEVGLPRPAPSARP 198

Query: 256 DPEAEAPPAGSIEAAPSSAAEPVIVSRSDP 285
            P  E P      A+  S  EP   +R  P
Sbjct: 199 RPPTEGPRKSVSSASEHSTTEPSPAARRRP 228


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score = 55.8 bits (133), Expect = 8e-08
 Identities = 89/312 (28%), Positives = 109/312 (34%), Gaps = 62/312 (19%)

Query: 12  PAGAPGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAV---- 67
           PA A  P  A P+PPA+         PP +  A P P+     P A A H   A      
Sbjct: 359 PALALPPLQAPPSPPAS---------PPLSPLATPSPQA----PNALAVHLLQAPFSPPP 405

Query: 68  -PAAKMPAFSSCFEVVSGAAAPASAAAG---------PPGASCKPPLPPHYTSTAQITVR 117
            P  + P        VS +A P S A           PP     PP+ P  T   Q    
Sbjct: 406 SPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQ-APP 464

Query: 118 ALGADRLLLHGPD---------------PVPGAAGSAAAPRGRCLLLAPAPAAPVPPRRG 162
            L A  L L  P                P P A+    AP      L  +P A  PP+  
Sbjct: 465 PLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAP 524

Query: 163 S--SAWLLEELLRPDCPEPAGLDATRE----GPDRNFRLSEHRQALAAAKHRGPAATPGS 216
              +A LL+  + P  P    L A R     GPD +        ALA      P+ +P S
Sbjct: 525 PVLAAPLLQ--VPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSS 582

Query: 217 PDPGPGPWGEEHLAERGP---RGWERGGDRCDAPGGDAARRPDPEAEAPPAGSIEAAPSS 273
              GP   G    A   P   RG++ G      P G AA  P P+AE   A    AA S 
Sbjct: 583 TLSGPDLAGHSSSATSTPEELRGYDSG------PEGGAAASPPPDAEL--AACHPAAWSR 634

Query: 274 AAEPVIVSRSDP 285
              P +  R  P
Sbjct: 635 GPAPPLAFRGAP 646



 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 79/298 (26%), Positives = 102/298 (34%), Gaps = 65/298 (21%)

Query: 12  PAGAPGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAVPAAK 71
           P+  P P A    PP AA P +++  PP            +  PA A    +A   P A 
Sbjct: 454 PSATPPPQAP---PPLAAPPLQLAKPPP------------QAPPALATPPLQALPSPPAS 498

Query: 72  MPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLPPHYTS-TAQITVRALGADRLLLHGPD 130
            P  +        A+ P S  A PP     P  PP   +   Q+      +  L      
Sbjct: 499 FPGQA---PFSPSASLPMSPLATPP-----PQAPPVLAAPLLQVPPSPPASPTLQAPRRP 550

Query: 131 PVPGAAGSAAAPRGRCLLLAPAPAAPVPPRRGSSAWL----LEELLRPDCPEPAGLDATR 186
           P PG   S + PR   L LA AP  P PP R  S+ L    L          P  L    
Sbjct: 551 PTPGPDTSVSGPR---LTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYD 607

Query: 187 EGPDRNFRLSEHRQALAAAKH-----RGPA------ATPGSPDPGP---GPWGEEHLA-- 230
            GP+     S    A  AA H     RGPA        PG+P P P   GP   + L   
Sbjct: 608 SGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTI 667

Query: 231 ----------------ERGPRGWERGGDRCDAPGGDAARRPDPEAEAP--PAGSIEAA 270
                           + GP     GG      G  A+ R   +A     P G+++A+
Sbjct: 668 YETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQAS 725



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 76/294 (25%), Positives = 105/294 (35%), Gaps = 42/294 (14%)

Query: 15  APGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAVPAAKMPA 74
           A G     P P  +A P   +  P  +  +A E  T E  PAA    R  +A    + PA
Sbjct: 173 AAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAA---RRRPSAGGGLQRPA 229

Query: 75  FSSCFEVVSGAAAP-ASAAAGPPGASCKPPLPPHYTSTAQITVRALGADRLLLHGPDPVP 133
             S    +S +A P +S A   P A   P  P H +      ++AL   ++     D  P
Sbjct: 230 SRS----LSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAP 285

Query: 134 GAAGSAAAPRGRCLLLAPAPAAPVPPRRGSSAWLLEELLRPDCPEPAGLDATREGP---- 189
                +++P     L  P+P+AP  P    S   L+ L  P    P+    +   P    
Sbjct: 286 ALGPLSSSP-----LATPSPSAPPSPSAPPS---LQTLPSPPATPPSQATTSLGSPTLQA 337

Query: 190 DRNFRLSEHRQALAA---------------AKHRGPAATPGSPDPGPGPWGEEHLAE--- 231
             +F  S     LA                A    PA+ P SP   P P     LA    
Sbjct: 338 THSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLL 397

Query: 232 RGPRGWERGGDRCDAPGGDAARRPDPEAEAPPAGSIEAAPSSAAEPVIVSRSDP 285
           + P           AP    A  P   +  PP+   +A PS AA P+ V  S P
Sbjct: 398 QAPFS-PPPSPPVQAPFSPPASPPVSPSATPPS---QAPPSLAAPPLQVPPSPP 447



 Score = 38.9 bits (89), Expect = 0.010
 Identities = 62/266 (23%), Positives = 81/266 (30%), Gaps = 59/266 (22%)

Query: 21  AAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAVPAAKMPAFSSCFE 80
           AA   PAA  P  ++ +PPG+    P        P   A  R   A  A      +    
Sbjct: 12  AAARTPAARAPGLLTPRPPGSPRPPP--------PVTPAALRVLGAAGAVGRKPLAERAG 63

Query: 81  VVSGAAAPASAAAGPPGASCKPPLPPHYTSTAQITVRALGADRLLLHGPDPVPGAAGSAA 140
            + GA  P SA    P  + +PP              A G         +  PG   S  
Sbjct: 64  GIGGATIPESAPRAGPTRTSRPP--------------ASGRGERAPPAKNTSPGPVSSPG 109

Query: 141 APRGRCLLLAPAPAAPVPPRRGSSAWLLEELLRPDCPEPAGLDATREGPDRNFRLSEHRQ 200
              G      P P             L ++ LR    E        E P R+        
Sbjct: 110 RASG---TTRPGP-------------LGQKGLRISAEETVARGKATEAPKRS-------- 145

Query: 201 ALAAAKHRGPAA-TPGSPDPGPGPWGEEHLAERGPRGWERGGDRCDAPGGDAARRPDPEA 259
           AL+A   R  +  TPG+P P         +A R        G     P    + RP P  
Sbjct: 146 ALSAGARRDTSGPTPGTPSPA--------MARRS----RAAGTEVGLPRPAPSARPRPPT 193

Query: 260 EAPPAGSIEAAPSSAAEPVIVSRSDP 285
           E P      A+  S  EP   +R  P
Sbjct: 194 EGPRKSVSSASEHSTTEPSPAARRRP 219



 Score = 32.0 bits (71), Expect = 1.3
 Identities = 35/151 (23%), Positives = 52/151 (34%), Gaps = 12/151 (7%)

Query: 13  AGAPGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAVPAAKM 72
           + +P  T +  APP+ + P  +   P   A    +  T    P   A H    + P +  
Sbjct: 291 SSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLS-- 348

Query: 73  PAFSSCFEVVSGAAAPASAAAGPPGASCKPPLPPHYTSTAQ----ITVRALGADRLLLHG 128
           P  +   +     A P   A  PP     PPL P  T + Q    + V  L A       
Sbjct: 349 PLATPPPQAPPALALPPLQA--PPSPPASPPLSPLATPSPQAPNALAVHLLQAP----FS 402

Query: 129 PDPVPGAAGSAAAPRGRCLLLAPAPAAPVPP 159
           P P P      + P    +  +  P +  PP
Sbjct: 403 PPPSPPVQAPFSPPASPPVSPSATPPSQAPP 433


>gi|209977067 OTU domain containing 5 isoform c [Homo sapiens]
          Length = 349

 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 33/119 (27%), Positives = 61/119 (51%), Gaps = 6/119 (5%)

Query: 317 DGNCLYRAVSKTVYGDQSLHRELREQTVHYIADHLDHFSPLIEGDVGEFIIAAAQDGAWA 376
           DG CL+RAV+  VYGDQ +H  +R+  + Y+  + D+FS  +  D   +I    ++    
Sbjct: 4   DGACLFRAVADQVYGDQDMHEVVRKHCMDYLMKNADYFSNYVTEDFTTYINRKRKNNCHG 63

Query: 377 GYPELLAMGQMLNVNIHLTTGGRLESPTVSTMIHYLGPEDSLRPSIWLSWLSNGHYDAV 435
            + E+ AM +M N  + +    +  +  ++T   + G   +    I +S+  N HY++V
Sbjct: 64  NHIEMQAMAEMYNRPVEVY---QYSTEPINT---FHGIHQNEDEPIRVSYHRNIHYNSV 116


>gi|55741677 SET domain containing 1A [Homo sapiens]
          Length = 1707

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 64/220 (29%), Positives = 81/220 (36%), Gaps = 25/220 (11%)

Query: 21   AAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAVPAAKMP---AFSS 77
            A+PA PA  T       PP A    PEP  G   PA   + R ++ +P    P     + 
Sbjct: 1113 ASPARPAGPT----EESPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTV 1168

Query: 78   CFEVVSGAAAPASAAAGPPGASCKPPLPPHYTSTAQITVRALGADR--LLLHGPDPVPGA 135
             F  +    AP    A PP A    P         + T+R L  D   L+   P+ V   
Sbjct: 1169 SFSAIEVVPAPEPPPATPPQAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWPEEVSRG 1228

Query: 136  AGSAAAPRGRCL------------LLAPAPAAPVPPRRGSSAWLLEELLRPDCPEPAGLD 183
              S A  RGR              L   A  A  P RRG  A  L  +   +  E +  +
Sbjct: 1229 GRSRAGGRGRLTEEEEAEPGTEVDLAVLADLALTPARRGLPA--LPAVEDSEATETSD-E 1285

Query: 184  ATREGPDRNFRLSEHRQALAAAKHRGPAATPGSPDPGPGP 223
            A R  P  +  L EH  AL A K   PA     P+P P P
Sbjct: 1286 AERPRPLLSHILLEHNYAL-AVKPTPPAPALRPPEPVPAP 1324


>gi|149192871 OTU domain containing 3 [Homo sapiens]
          Length = 398

 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 36/123 (29%), Positives = 62/123 (50%), Gaps = 13/123 (10%)

Query: 317 DGNCLYRAVSKTVYGDQSLHRELREQTVHYIADHLDHFSPLIEGDV--GEFIIAAAQDGA 374
           DGNCL+RA+   + G    H + R++TV Y+    + F P +E D+   + + + A+ G 
Sbjct: 73  DGNCLFRALGDQLEGHSRNHLKHRQETVDYMIKQREDFEPFVEDDIPFEKHVASLAKPGT 132

Query: 375 WAGYPELLAMGQ--MLNVNIHLTTGGRLESPTVSTMIHYLGPEDSLRPSIWLSWLSNGHY 432
           +AG   ++A  +   LNV IH     +L +P    +    G E S    + +++    HY
Sbjct: 133 FAGNDAIVAFARNHQLNVVIH-----QLNAP----LWQIRGTEKSSVRELHIAYRYGEHY 183

Query: 433 DAV 435
           D+V
Sbjct: 184 DSV 186


>gi|111118976 collagen, type II, alpha 1 isoform 1 precursor [Homo
            sapiens]
          Length = 1487

 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 81/286 (28%), Positives = 94/286 (32%), Gaps = 48/286 (16%)

Query: 12   PAGAPGPTAA-------APAPPAAATPFKVSLQPPGAAGAA-------PEPETGECQPAA 57
            P GAPG            P  PA A   K  + PPG AG+A          ETG   PA 
Sbjct: 775  PEGAPGKDGGRGLTGPIGPPGPAGANGEKGEVGPPGPAGSAGARGAPGERGETGPPGPAG 834

Query: 58   AAEHREAAAVPAAKMPAFSSCFEVVSGAAAP--ASAAAGPPGASCKPPLPPHYTSTAQIT 115
             A    A   P AK     +  +  +GA  P   S A GP G +      P     AQ  
Sbjct: 835  FAGPPGADGQPGAKGEQGEAGQKGDAGAPGPQGPSGAPGPQGPT--GVTGPKGARGAQGP 892

Query: 116  VRALGADRLLLHGPDPVPGAAGSAAAPRGRCLLLAPAPAAPV-------------PPRRG 162
              A G            PGAAG    P        P P  P              PP R 
Sbjct: 893  PGATG-----------FPGAAGRVGPPGSNGNPGPPGPPGPSGKDGPKGARGDSGPPGRA 941

Query: 163  SSAWLLEELLRPDCPEPAGLD--ATREGPDRNFRLSEHRQALAAAKHRGPAATPGSPDPG 220
                L      P      G D  +  EGP     L+  R  +     RG    PG P P 
Sbjct: 942  GEPGLQGPAGPPGEKGEPGDDGPSGAEGPPGPQGLAGQRGIVGLPGQRGERGFPGLPGPS 1001

Query: 221  --PGPWGEEHLA-ERGPRGWERGGDRCDAPGGDAARRPDPEAEAPP 263
              PG  G    + +RGP G   G      P G+  R   P A+ PP
Sbjct: 1002 GEPGKQGAPGASGDRGPPG-PVGPPGLTGPAGEPGREGSPGADGPP 1046



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 87/281 (30%), Positives = 102/281 (36%), Gaps = 57/281 (20%)

Query: 13  AGAPGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHRE------AAA 66
           AGAPG    + +P    +P  +   P G  G     E G   PA AA  R        A 
Sbjct: 302 AGAPGVKGESGSPGENGSPGPMG--PRGLPG-----ERGRTGPAGAAGARGNDGQPGPAG 354

Query: 67  VPAAKMPAFSSCFEVVSGAAAPA--SAAAGPPGASCKPPLPPHYTSTAQITVRALGADRL 124
            P    PA    F    GA   A  + A GP GA  + P     T  +     A G    
Sbjct: 355 PPGPVGPAGGPGFPGAPGAKGEAGPTGARGPEGA--QGPRGEPGTPGSPGPAGASGNP-- 410

Query: 125 LLHGPDPVPGAAGSAAAPRGRCLLLAPAPAAPVPPRRGSSAWLLEELLRPDCPEPAGLDA 184
              G D +PGA GSA AP      +A AP  P P  RG              P P G   
Sbjct: 411 ---GTDGIPGAKGSAGAPG-----IAGAPGFPGP--RGP-------------PGPQGATG 447

Query: 185 TREGPDRNFRLSEHRQALAAAK-HRGPAATPG--SPDPGPGPWGEEHLAERGPRGWERGG 241
              GP    +       +A  K  +GP   PG   P   PGP GEE   +RG RG   G 
Sbjct: 448 PL-GP----KGQTGEPGIAGFKGEQGPKGEPGPAGPQGAPGPAGEE--GKRGARGEPGGV 500

Query: 242 DRCDAPG--GDAARR--PDPEAEAPPAGSI-EAAPSSAAEP 277
                PG  G    R  P  +  A P G+  E  PS  A P
Sbjct: 501 GPIGPPGERGAPGNRGFPGQDGLAGPKGAPGERGPSGLAGP 541



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 77/268 (28%), Positives = 92/268 (34%), Gaps = 52/268 (19%)

Query: 12  PAGAPGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEP-ETGECQPAAAAEHREAAAVPAA 70
           PAG PGP   A  P             PGA GA  E   TG   P  A   R     P +
Sbjct: 352 PAGPPGPVGPAGGPGF-----------PGAPGAKGEAGPTGARGPEGAQGPRGEPGTPGS 400

Query: 71  KMPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLP-PHYTSTAQITVRALGADRLLLHGP 129
             PA +S      G    A  +AG PG +  P  P P      Q     LG       G 
Sbjct: 401 PGPAGASGNPGTDGIPG-AKGSAGAPGIAGAPGFPGPRGPPGPQGATGPLGP-----KGQ 454

Query: 130 DPVPGAAG--SAAAPRGRCLLLAPAPAAPVPPRRGSSAWLLEELLRPDCPEPAGLDATRE 187
              PG AG      P+G      P PA P    +G+     EE  R    EP G+     
Sbjct: 455 TGEPGIAGFKGEQGPKGE-----PGPAGP----QGAPGPAGEEGKRGARGEPGGVGPIGP 505

Query: 188 GPDRNFRLSEHRQALAAAKHRGPAATPG--SPDPGPGPWGEEHLAERGPRGWERGGDRCD 245
             +R            A  +RG     G   P   PG  G   LA  GP+G      R  
Sbjct: 506 PGER-----------GAPGNRGFPGQDGLAGPKGAPGERGPSGLA--GPKGANGDPGRPG 552

Query: 246 APGGDAAR----RP---DPEAEAPPAGS 266
            PG   AR    RP    P+ +  P+G+
Sbjct: 553 EPGLPGARGLTGRPGDAGPQGKVGPSGA 580



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 71/267 (26%), Positives = 83/267 (31%), Gaps = 43/267 (16%)

Query: 12  PAGAPGP-----TAAAPAPPAAATPFKVSLQPPGAAGAAPEP-ETGEC-QPAAAAEHREA 64
           PAGAPGP         P  P  + P    + P G  G   +P + GE  +P  A E    
Sbjct: 214 PAGAPGPQGFQGNPGEPGEPGVSGP----MGPRGPPGPPGKPGDDGEAGKPGKAGERGPP 269

Query: 65  AAVPAAKMPAFSSCFEVVSGAAAP----ASAAAGPPGASCKPPLPPHYTSTAQITVRALG 120
               A   P       V      P    A   AG PG   +   P    S   +  R L 
Sbjct: 270 GPQGARGFPGTPGLPGVKGHRGYPGLDGAKGEAGAPGVKGESGSPGENGSPGPMGPRGLP 329

Query: 121 ADRLLLHGPDPVPGAAGSAAAPRGRCLLLAPA-PAAPVPPRRGSSAWLLEELLRPDCPEP 179
            +R    GP    GA G+   P        PA P  PV P  G           P  P  
Sbjct: 330 GERGRT-GPAGAAGARGNDGQP-------GPAGPPGPVGPAGGPGF--------PGAPGA 373

Query: 180 AGLDATREGPDRNFRLSEHRQALAAAKHRGPAATPGSPDPGPGPWGEEHLAERGPRGWER 239
            G      GP      +  R    A   RG   TPGSP P             G +G   
Sbjct: 374 KG----EAGP------TGARGPEGAQGPRGEPGTPGSPGPAGASGNPGTDGIPGAKGSAG 423

Query: 240 GGDRCDAPGGDAAR-RPDPEAEAPPAG 265
                 APG    R  P P+    P G
Sbjct: 424 APGIAGAPGFPGPRGPPGPQGATGPLG 450



 Score = 33.5 bits (75), Expect = 0.44
 Identities = 70/294 (23%), Positives = 86/294 (29%), Gaps = 52/294 (17%)

Query: 14  GAPGPTA--AAPAPPAAATPFKVSLQPPGAAGAAPEPET-GECQPAAAAEHREAAAVPAA 70
           GAPGP+     P PP           PPG  G   +    GE         R     P  
Sbjct: 657 GAPGPSGFQGLPGPPG----------PPGEGGKPGDQGVPGEAGAPGLVGPRGERGFPGE 706

Query: 71  KMPAFSSCFEVVSGAAAP--------ASAAAGPPGASCKPPLPPHYTSTAQITVRALGAD 122
           +    +   +   G            AS  AGPPGA   P L           +     D
Sbjct: 707 RGSPGAQGLQGPRGLPGTPGTDGPKGASGPAGPPGAQGPPGLQGMPGERGAAGIAGPKGD 766

Query: 123 R--LLLHGPDPVPGAAG--SAAAPRGRCLLLAPAPAA----------PVPPRRGSSAWLL 168
           R  +   GP+  PG  G      P G      P PA           P P     +    
Sbjct: 767 RGDVGEKGPEGAPGKDGGRGLTGPIG-----PPGPAGANGEKGEVGPPGPAGSAGARGAP 821

Query: 169 EELLRPDCPEPAGLDATREGPDRNFRLSEHRQALAAAKHRGPAATPG--SPDPGPGPWGE 226
            E      P PAG      GP         +     A  +G A  PG   P   PGP G 
Sbjct: 822 GERGETGPPGPAGF----AGPPGADGQPGAKGEQGEAGQKGDAGAPGPQGPSGAPGPQGP 877

Query: 227 EHL-AERGPRGWERGGDRCDAPG-----GDAARRPDPEAEAPPAGSIEAAPSSA 274
             +   +G RG +        PG     G      +P    PP  S +  P  A
Sbjct: 878 TGVTGPKGARGAQGPPGATGFPGAAGRVGPPGSNGNPGPPGPPGPSGKDGPKGA 931



 Score = 32.7 bits (73), Expect = 0.75
 Identities = 77/274 (28%), Positives = 91/274 (33%), Gaps = 70/274 (25%)

Query: 12   PAGAPG----PTAAAPAPPAAATPFKVSLQPPGAAGA--APEP--ETGECQPAAAAEHRE 63
            PAG PG    P A  P     A   K      GA GA  AP P    G   P      R 
Sbjct: 1030 PAGEPGREGSPGADGPPGRDGAAGVKGDRGETGAVGAPGAPGPPGSPGPAGPTGKQGDRG 1089

Query: 64   AAAVPAAKMPAFSSCFEVVSGAAAPAS--AAAGPPGASCKPPLPPHYTSTAQITVRALGA 121
             A       P+  +    + G   P      AG PG   +  L  H   T    ++ L  
Sbjct: 1090 EAGAQGPMGPSGPAGARGIQGPQGPRGDKGEAGEPG---ERGLKGHRGFTG---LQGLPG 1143

Query: 122  DRLLLHGPDPVPGAAGSA--AAPRGRCLLLAPAPAAPVPPRRGSSAWLLEELLRPDCPEP 179
                  GP    GA+G A  + PRG        P  PV P     A  +   + P  P P
Sbjct: 1144 PP----GPSGDQGASGPAGPSGPRG--------PPGPVGPSGKDGANGIPGPIGP--PGP 1189

Query: 180  AGLDATREGPDRNFRLSEHRQALAAAKHRGPAATPGSPDPGPGPWGE-------EHLAER 232
             G    R G                    GPA  PG+P P PGP G           A  
Sbjct: 1190 RG----RSG------------------ETGPAGPPGNPGP-PGPPGPPGPGIDMSAFAGL 1226

Query: 233  GPRGWERGGD-----RCDAPGGDAARRPDPEAEA 261
            GPR  E+G D     R D   G   R+ D E +A
Sbjct: 1227 GPR--EKGPDPLQYMRADQAAG-GLRQHDAEVDA 1257


>gi|111118974 collagen, type II, alpha 1 isoform 2 precursor [Homo
           sapiens]
          Length = 1418

 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 81/286 (28%), Positives = 94/286 (32%), Gaps = 48/286 (16%)

Query: 12  PAGAPGPTAA-------APAPPAAATPFKVSLQPPGAAGAA-------PEPETGECQPAA 57
           P GAPG            P  PA A   K  + PPG AG+A          ETG   PA 
Sbjct: 706 PEGAPGKDGGRGLTGPIGPPGPAGANGEKGEVGPPGPAGSAGARGAPGERGETGPPGPAG 765

Query: 58  AAEHREAAAVPAAKMPAFSSCFEVVSGAAAP--ASAAAGPPGASCKPPLPPHYTSTAQIT 115
            A    A   P AK     +  +  +GA  P   S A GP G +      P     AQ  
Sbjct: 766 FAGPPGADGQPGAKGEQGEAGQKGDAGAPGPQGPSGAPGPQGPT--GVTGPKGARGAQGP 823

Query: 116 VRALGADRLLLHGPDPVPGAAGSAAAPRGRCLLLAPAPAAPV-------------PPRRG 162
             A G            PGAAG    P        P P  P              PP R 
Sbjct: 824 PGATG-----------FPGAAGRVGPPGSNGNPGPPGPPGPSGKDGPKGARGDSGPPGRA 872

Query: 163 SSAWLLEELLRPDCPEPAGLD--ATREGPDRNFRLSEHRQALAAAKHRGPAATPGSPDPG 220
               L      P      G D  +  EGP     L+  R  +     RG    PG P P 
Sbjct: 873 GEPGLQGPAGPPGEKGEPGDDGPSGAEGPPGPQGLAGQRGIVGLPGQRGERGFPGLPGPS 932

Query: 221 --PGPWGEEHLA-ERGPRGWERGGDRCDAPGGDAARRPDPEAEAPP 263
             PG  G    + +RGP G   G      P G+  R   P A+ PP
Sbjct: 933 GEPGKQGAPGASGDRGPPG-PVGPPGLTGPAGEPGREGSPGADGPP 977



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 87/281 (30%), Positives = 102/281 (36%), Gaps = 57/281 (20%)

Query: 13  AGAPGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHRE------AAA 66
           AGAPG    + +P    +P  +   P G  G     E G   PA AA  R        A 
Sbjct: 233 AGAPGVKGESGSPGENGSPGPMG--PRGLPG-----ERGRTGPAGAAGARGNDGQPGPAG 285

Query: 67  VPAAKMPAFSSCFEVVSGAAAPA--SAAAGPPGASCKPPLPPHYTSTAQITVRALGADRL 124
            P    PA    F    GA   A  + A GP GA  + P     T  +     A G    
Sbjct: 286 PPGPVGPAGGPGFPGAPGAKGEAGPTGARGPEGA--QGPRGEPGTPGSPGPAGASGNP-- 341

Query: 125 LLHGPDPVPGAAGSAAAPRGRCLLLAPAPAAPVPPRRGSSAWLLEELLRPDCPEPAGLDA 184
              G D +PGA GSA AP      +A AP  P P  RG              P P G   
Sbjct: 342 ---GTDGIPGAKGSAGAPG-----IAGAPGFPGP--RGP-------------PGPQGATG 378

Query: 185 TREGPDRNFRLSEHRQALAAAK-HRGPAATPG--SPDPGPGPWGEEHLAERGPRGWERGG 241
              GP    +       +A  K  +GP   PG   P   PGP GEE   +RG RG   G 
Sbjct: 379 PL-GP----KGQTGEPGIAGFKGEQGPKGEPGPAGPQGAPGPAGEE--GKRGARGEPGGV 431

Query: 242 DRCDAPG--GDAARR--PDPEAEAPPAGSI-EAAPSSAAEP 277
                PG  G    R  P  +  A P G+  E  PS  A P
Sbjct: 432 GPIGPPGERGAPGNRGFPGQDGLAGPKGAPGERGPSGLAGP 472



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 77/268 (28%), Positives = 92/268 (34%), Gaps = 52/268 (19%)

Query: 12  PAGAPGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEP-ETGECQPAAAAEHREAAAVPAA 70
           PAG PGP   A  P             PGA GA  E   TG   P  A   R     P +
Sbjct: 283 PAGPPGPVGPAGGPGF-----------PGAPGAKGEAGPTGARGPEGAQGPRGEPGTPGS 331

Query: 71  KMPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLP-PHYTSTAQITVRALGADRLLLHGP 129
             PA +S      G    A  +AG PG +  P  P P      Q     LG       G 
Sbjct: 332 PGPAGASGNPGTDGIPG-AKGSAGAPGIAGAPGFPGPRGPPGPQGATGPLGP-----KGQ 385

Query: 130 DPVPGAAG--SAAAPRGRCLLLAPAPAAPVPPRRGSSAWLLEELLRPDCPEPAGLDATRE 187
              PG AG      P+G      P PA P    +G+     EE  R    EP G+     
Sbjct: 386 TGEPGIAGFKGEQGPKGE-----PGPAGP----QGAPGPAGEEGKRGARGEPGGVGPIGP 436

Query: 188 GPDRNFRLSEHRQALAAAKHRGPAATPG--SPDPGPGPWGEEHLAERGPRGWERGGDRCD 245
             +R            A  +RG     G   P   PG  G   LA  GP+G      R  
Sbjct: 437 PGER-----------GAPGNRGFPGQDGLAGPKGAPGERGPSGLA--GPKGANGDPGRPG 483

Query: 246 APGGDAAR----RP---DPEAEAPPAGS 266
            PG   AR    RP    P+ +  P+G+
Sbjct: 484 EPGLPGARGLTGRPGDAGPQGKVGPSGA 511



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 71/267 (26%), Positives = 83/267 (31%), Gaps = 43/267 (16%)

Query: 12  PAGAPGP-----TAAAPAPPAAATPFKVSLQPPGAAGAAPEP-ETGEC-QPAAAAEHREA 64
           PAGAPGP         P  P  + P    + P G  G   +P + GE  +P  A E    
Sbjct: 145 PAGAPGPQGFQGNPGEPGEPGVSGP----MGPRGPPGPPGKPGDDGEAGKPGKAGERGPP 200

Query: 65  AAVPAAKMPAFSSCFEVVSGAAAP----ASAAAGPPGASCKPPLPPHYTSTAQITVRALG 120
               A   P       V      P    A   AG PG   +   P    S   +  R L 
Sbjct: 201 GPQGARGFPGTPGLPGVKGHRGYPGLDGAKGEAGAPGVKGESGSPGENGSPGPMGPRGLP 260

Query: 121 ADRLLLHGPDPVPGAAGSAAAPRGRCLLLAPA-PAAPVPPRRGSSAWLLEELLRPDCPEP 179
            +R    GP    GA G+   P        PA P  PV P  G           P  P  
Sbjct: 261 GERGRT-GPAGAAGARGNDGQP-------GPAGPPGPVGPAGGPGF--------PGAPGA 304

Query: 180 AGLDATREGPDRNFRLSEHRQALAAAKHRGPAATPGSPDPGPGPWGEEHLAERGPRGWER 239
            G      GP      +  R    A   RG   TPGSP P             G +G   
Sbjct: 305 KG----EAGP------TGARGPEGAQGPRGEPGTPGSPGPAGASGNPGTDGIPGAKGSAG 354

Query: 240 GGDRCDAPGGDAAR-RPDPEAEAPPAG 265
                 APG    R  P P+    P G
Sbjct: 355 APGIAGAPGFPGPRGPPGPQGATGPLG 381



 Score = 33.5 bits (75), Expect = 0.44
 Identities = 70/294 (23%), Positives = 86/294 (29%), Gaps = 52/294 (17%)

Query: 14  GAPGPTA--AAPAPPAAATPFKVSLQPPGAAGAAPEPET-GECQPAAAAEHREAAAVPAA 70
           GAPGP+     P PP           PPG  G   +    GE         R     P  
Sbjct: 588 GAPGPSGFQGLPGPPG----------PPGEGGKPGDQGVPGEAGAPGLVGPRGERGFPGE 637

Query: 71  KMPAFSSCFEVVSGAAAP--------ASAAAGPPGASCKPPLPPHYTSTAQITVRALGAD 122
           +    +   +   G            AS  AGPPGA   P L           +     D
Sbjct: 638 RGSPGAQGLQGPRGLPGTPGTDGPKGASGPAGPPGAQGPPGLQGMPGERGAAGIAGPKGD 697

Query: 123 R--LLLHGPDPVPGAAG--SAAAPRGRCLLLAPAPAA----------PVPPRRGSSAWLL 168
           R  +   GP+  PG  G      P G      P PA           P P     +    
Sbjct: 698 RGDVGEKGPEGAPGKDGGRGLTGPIG-----PPGPAGANGEKGEVGPPGPAGSAGARGAP 752

Query: 169 EELLRPDCPEPAGLDATREGPDRNFRLSEHRQALAAAKHRGPAATPG--SPDPGPGPWGE 226
            E      P PAG      GP         +     A  +G A  PG   P   PGP G 
Sbjct: 753 GERGETGPPGPAGF----AGPPGADGQPGAKGEQGEAGQKGDAGAPGPQGPSGAPGPQGP 808

Query: 227 EHL-AERGPRGWERGGDRCDAPG-----GDAARRPDPEAEAPPAGSIEAAPSSA 274
             +   +G RG +        PG     G      +P    PP  S +  P  A
Sbjct: 809 TGVTGPKGARGAQGPPGATGFPGAAGRVGPPGSNGNPGPPGPPGPSGKDGPKGA 862



 Score = 32.7 bits (73), Expect = 0.75
 Identities = 77/274 (28%), Positives = 91/274 (33%), Gaps = 70/274 (25%)

Query: 12   PAGAPG----PTAAAPAPPAAATPFKVSLQPPGAAGA--APEP--ETGECQPAAAAEHRE 63
            PAG PG    P A  P     A   K      GA GA  AP P    G   P      R 
Sbjct: 961  PAGEPGREGSPGADGPPGRDGAAGVKGDRGETGAVGAPGAPGPPGSPGPAGPTGKQGDRG 1020

Query: 64   AAAVPAAKMPAFSSCFEVVSGAAAPAS--AAAGPPGASCKPPLPPHYTSTAQITVRALGA 121
             A       P+  +    + G   P      AG PG   +  L  H   T    ++ L  
Sbjct: 1021 EAGAQGPMGPSGPAGARGIQGPQGPRGDKGEAGEPG---ERGLKGHRGFTG---LQGLPG 1074

Query: 122  DRLLLHGPDPVPGAAGSA--AAPRGRCLLLAPAPAAPVPPRRGSSAWLLEELLRPDCPEP 179
                  GP    GA+G A  + PRG        P  PV P     A  +   + P  P P
Sbjct: 1075 PP----GPSGDQGASGPAGPSGPRG--------PPGPVGPSGKDGANGIPGPIGP--PGP 1120

Query: 180  AGLDATREGPDRNFRLSEHRQALAAAKHRGPAATPGSPDPGPGPWGE-------EHLAER 232
             G    R G                    GPA  PG+P P PGP G           A  
Sbjct: 1121 RG----RSG------------------ETGPAGPPGNPGP-PGPPGPPGPGIDMSAFAGL 1157

Query: 233  GPRGWERGGD-----RCDAPGGDAARRPDPEAEA 261
            GPR  E+G D     R D   G   R+ D E +A
Sbjct: 1158 GPR--EKGPDPLQYMRADQAAG-GLRQHDAEVDA 1188


>gi|110556644 zinc finger protein, multitype 1 [Homo sapiens]
          Length = 1006

 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 82/278 (29%), Positives = 95/278 (34%), Gaps = 59/278 (21%)

Query: 12  PAGAPGPTAAAPAPPAAA---TPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAVP 68
           P G PGP AA PAP  AA   T  +  L    AAGA P P  G            A A  
Sbjct: 720 PPGPPGP-AAPPAPSPAAPVRTRRRRKLYELHAAGAPPPPPPG-----------HAPAPE 767

Query: 69  AAKMPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLP-PHYTSTAQITVRALGADRLLLH 127
           + +  + S     ++ A +P  AA GP   S KP  P P   + A        A R+  H
Sbjct: 768 SPRPGSGSGSGPGLAPARSPGPAADGPIDLSKKPRRPLPGAPAPALADYHECTACRVSFH 827

Query: 128 GPDPVPGAAGSAAAPRGRCLLLAPAPAAPVPPRRGSSAWLLEELLRPDCPEPAGLDATRE 187
             +         A  +  C      PAAP P   G     L     P CP          
Sbjct: 828 SLE------AYLAHKKYSC------PAAPPPGALG-----LPAAACPYCPP--------N 862

Query: 188 GPDRNFRLSEHRQA---LAAAKHRGP---AATPG--SPDPGPGPWGEEHLAERGPRGWER 239
           GP R   L   R A   L  A   GP   A TP    P P P P        RGPR    
Sbjct: 863 GPVRGDLLEHFRLAHGLLLGAPLAGPGVEARTPADRGPSPAPAPAASPQPGSRGPRDGL- 921

Query: 240 GGDRCDAPGGDAARRPDPEAEAPPAGSIEAAPSSAAEP 277
                    G   + P P     PA + EA P   A P
Sbjct: 922 ---------GPEPQEPPPGPPPSPAAAPEAVPPPPAPP 950



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 64/226 (28%), Positives = 75/226 (33%), Gaps = 36/226 (15%)

Query: 15  APGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAVPAAKMPA 74
           AP    AA  P A   P +    PPG   A P+       P A  E    AA P      
Sbjct: 605 APEDAPAARRPKAPPGPARA---PPGQP-AEPDAPRSSPGPGAREEGAGGAATPE----- 655

Query: 75  FSSCFEVVSGAAAPASAAAGPPGASCKPPLP-PHYTSTAQITVRALGADRLLLHGP---- 129
                    GA    S  +  PG+S       P  T      +R    +   +H      
Sbjct: 656 --------DGAGGRGSEGSQSPGSSVDDAEDDPSRTLCEACNIRFSRHETYTVHKRYYCA 707

Query: 130 ---DPVPGAAGSAAAPRGRCLLLAPAPAAPVPPRRGSSAWLLEELLRPDCPEPAGLDATR 186
              DP P    +   P G     AP+PAAPV  RR    + L     P  P P G     
Sbjct: 708 SRHDPPPRRPAAPPGPPGPAAPPAPSPAAPVRTRRRRKLYELHAAGAPP-PPPPGHAPAP 766

Query: 187 EGPDRNFRLSEHRQALAAAKHRGPAA--------TPGSPDPG-PGP 223
           E P R    S     LA A+  GPAA         P  P PG P P
Sbjct: 767 ESP-RPGSGSGSGPGLAPARSPGPAADGPIDLSKKPRRPLPGAPAP 811



 Score = 29.3 bits (64), Expect = 8.3
 Identities = 27/85 (31%), Positives = 32/85 (37%), Gaps = 11/85 (12%)

Query: 13  AGAPGPTAAAPAPPAAATPFKVSLQPPGAAGAAP-EPETG-ECQPAAAAEHREAAAVPAA 70
           A  P     +PAP  AA+P   S  P    G  P EP  G    PAAA E    A  P  
Sbjct: 892 ARTPADRGPSPAPAPAASPQPGSRGPRDGLGPEPQEPPPGPPPSPAAAPE----AVPPPP 947

Query: 71  KMPAFSSCFEVVSGAAAPASAAAGP 95
             P++S       G   P+     P
Sbjct: 948 APPSYSD-----KGVQTPSKGTPAP 967


>gi|169211815 PREDICTED: keratin associated protein 4.6 [Homo
           sapiens]
          Length = 288

 Score = 52.4 bits (124), Expect = 9e-07
 Identities = 48/147 (32%), Positives = 62/147 (42%), Gaps = 23/147 (15%)

Query: 12  PAGAPGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAVPAAK 71
           PA  P    AA  PPAA         PP AA AA  P   +   A+       AAVPAA 
Sbjct: 138 PAAVPAAVPAAVRPPAAG--------PPAAALAAVYPAAADPSAASLCAASPLAAVPAAA 189

Query: 72  MPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLPPHYTSTAQITVRALGADRLLLHGPDP 131
            PA  +   V  GAA P++A+     A+ +P   P   S A     A+            
Sbjct: 190 SPAAVAPAAVCPGAAGPSAASL---CAASQPAAVPAAASPAAAAPLAVNP---------- 236

Query: 132 VPGAAGSAAAPRGRCL-LLAPAPAAPV 157
              AA +AAAP   C+  +A +PA P+
Sbjct: 237 -AAAARAAAAPAAACVQSVAESPATPL 262



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 47/139 (33%), Positives = 58/139 (41%), Gaps = 30/139 (21%)

Query: 5   SSVCTHYPAGAPGPTAAAPAP--PAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHR 62
           +S+C   P  A  P AA+PA   PAA          PGAAG +        QP       
Sbjct: 174 ASLCAASPLAAV-PAAASPAAVAPAAVC--------PGAAGPSAASLCAASQP------- 217

Query: 63  EAAAVPAAKMPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLPPHYTSTAQITVRALGAD 122
             AAVPAA  PA ++   V   AAA A+AA   P A+C         S A+     L   
Sbjct: 218 --AAVPAAASPAAAAPLAVNPAAAARAAAA---PAAAC-------VQSVAESPATPLAIA 265

Query: 123 RLLLHGPDPVPGAAGSAAA 141
           + +   P PVP A    AA
Sbjct: 266 QPVSFPPAPVPCAVPPLAA 284



 Score = 38.9 bits (89), Expect = 0.010
 Identities = 60/204 (29%), Positives = 78/204 (38%), Gaps = 25/204 (12%)

Query: 18  PTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAVPAAKMPAFSS 77
           P +A    P+A T  +     P AA AA  P      PAAA     AA  PAA  P+ +S
Sbjct: 79  PWSAPVVVPSALT--RAVAWRPAAAPAAVRPPAAG-PPAAA----PAAVCPAAADPSAAS 131

Query: 78  CFEVVSGAAAPASAAAGPPGASCKPPLPPHYTSTAQITVRALGADRLLLHGPDPVPGAAG 137
               +  A+ PA+  A  P A   P   P   + A +   A       L    P+  A  
Sbjct: 132 ----LCAASPPAAVPAAVPAAVRPPAAGPPAAALAAVYPAAADPSAASLCAASPL-AAVP 186

Query: 138 SAAAPRGRCLLLAPAPAAPVPPRRGSSAWLL----EELLRPDCPEPAGLDATREGPDRNF 193
           +AA+P       A APAA  P   G SA  L    +    P    PA        P    
Sbjct: 187 AAASP------AAVAPAAVCPGAAGPSAASLCAASQPAAVPAAASPAAAAPLAVNPAAAA 240

Query: 194 RLSEHRQALAAAKHRGPAATPGSP 217
           R +    A AAA  +  A +P +P
Sbjct: 241 RAA---AAPAAACVQSVAESPATP 261



 Score = 30.0 bits (66), Expect = 4.9
 Identities = 50/166 (30%), Positives = 58/166 (34%), Gaps = 36/166 (21%)

Query: 58  AAEHREAAAVPAAKMPAFSSCFEVVSGAAAPAS---AAAGPPGASCKPPLPPHYTSTAQI 114
           A   R AAA  A + PA          AAAPA+   AAA P  AS     PP     A +
Sbjct: 93  AVAWRPAAAPAAVRPPAAG------PPAAAPAAVCPAAADPSAASLCAASPP-----AAV 141

Query: 115 TVRALGADRLLLHGPDPVP-GAAGSAAAPRGRCLLLAPAPAAPVPPRRGSSAWLLEELLR 173
                 A R    GP      A   AAA      L A +P A VP     +A     +  
Sbjct: 142 PAAVPAAVRPPAAGPPAAALAAVYPAAADPSAASLCAASPLAAVPAAASPAAVAPAAV-- 199

Query: 174 PDCPEPAGLDATREGPDRNFRLSEHRQALAAAKHRGPAATPGSPDP 219
             CP  AG  A                +L AA    PAA P +  P
Sbjct: 200 --CPGAAGPSAA---------------SLCAASQ--PAAVPAAASP 226


>gi|222418647 mucin 7, secreted precursor [Homo sapiens]
          Length = 377

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 51/165 (30%), Positives = 63/165 (38%), Gaps = 24/165 (14%)

Query: 5   SSVCTHYPAGAPGP--TAAAPAPPAAATPFKVSLQ-PPGAAGAAPEPE-TGECQPAAAAE 60
           SSV T  P  +P P  T AAP  P+A TP   S   PP    A P P  T +  P+++A 
Sbjct: 149 SSVATLAPVNSPAPQDTTAAPPTPSATTPAPPSSSAPPETTAAPPTPSATTQAPPSSSAP 208

Query: 61  HREAAA--VPAAKMPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLP-----PHYTSTAQ 113
               AA   P A  PA  S       ++AP    A PP  S   P P     P  T+   
Sbjct: 209 PETTAAPPTPPATTPAPPS-------SSAPPETTAAPPTPSATTPAPLSSSAPPETTAVP 261

Query: 114 ITVRALGADRLLLHGPDPVPGAAGSAAAPRGRCLLLAPAPAAPVP 158
            T  A   D      P        + AAP          P++P P
Sbjct: 262 PTPSATTLD------PSSASAPPETTAAPPTPSATTPAPPSSPAP 300



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 34/111 (30%), Positives = 45/111 (40%), Gaps = 11/111 (9%)

Query: 5   SSVCTHYPAGAPGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREA 64
           SS      A  P P A  PAPP+++ P + +  PP  +   P P +    P       E 
Sbjct: 205 SSAPPETTAAPPTPPATTPAPPSSSAPPETTAAPPTPSATTPAPLSSSAPP-------ET 257

Query: 65  AAVPAAKMPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLPPHYTSTAQIT 115
            AVP    P  S+     S A+AP    A PP  S   P PP   +  + T
Sbjct: 258 TAVP----PTPSATTLDPSSASAPPETTAAPPTPSATTPAPPSSPAPQETT 304



 Score = 33.5 bits (75), Expect = 0.44
 Identities = 20/56 (35%), Positives = 23/56 (41%)

Query: 13  AGAPGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAVP 68
           A AP  T AAP  P+A TP   S   P    AAP           A +  E +A P
Sbjct: 274 ASAPPETTAAPPTPSATTPAPPSSPAPQETTAAPITTPNSSPTTLAPDTSETSAAP 329



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 28/105 (26%), Positives = 40/105 (38%), Gaps = 18/105 (17%)

Query: 13  AGAPGPTAAAPAPPAAAT--PFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAVPAA 70
           + AP  T A P  P+A T  P   S  PP    A P P      P ++   +E  A P  
Sbjct: 251 SSAPPETTAVPPTPSATTLDPSSASA-PPETTAAPPTPSATTPAPPSSPAPQETTAAP-- 307

Query: 71  KMPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLPPHYTSTAQIT 115
                     + +  ++P + A   P  S     P H T+T+  T
Sbjct: 308 ----------ITTPNSSPTTLA---PDTSETSAAPTHQTTTSVTT 339



 Score = 31.2 bits (69), Expect = 2.2
 Identities = 41/153 (26%), Positives = 48/153 (31%), Gaps = 20/153 (13%)

Query: 133 PGAAGSAAAPRGRCLLLAPAPAAPVPPRRGSSAWLLEELLRPDCPEPAGLDATREGPDRN 192
           P    + AAP        P+   P PP   SS+   E    P  P      AT + P  +
Sbjct: 160 PAPQDTTAAPP------TPSATTPAPP---SSSAPPETTAAPPTPS-----ATTQAPPSS 205

Query: 193 FRLSEHRQALAAAKHRGPAATPGSPDPGPGPWGEEHLAERGPRGWERGGDRCDAPGGDAA 252
               E      AA    PA TP  P     P  E   A   P           AP    A
Sbjct: 206 SAPPE----TTAAPPTPPATTPAPPSSSAPP--ETTAAPPTPSATTPAPLSSSAPPETTA 259

Query: 253 RRPDPEAEAPPAGSIEAAPSSAAEPVIVSRSDP 285
             P P A      S  A P + A P   S + P
Sbjct: 260 VPPTPSATTLDPSSASAPPETTAAPPTPSATTP 292


>gi|222418649 mucin 7, secreted precursor [Homo sapiens]
          Length = 377

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 51/165 (30%), Positives = 63/165 (38%), Gaps = 24/165 (14%)

Query: 5   SSVCTHYPAGAPGP--TAAAPAPPAAATPFKVSLQ-PPGAAGAAPEPE-TGECQPAAAAE 60
           SSV T  P  +P P  T AAP  P+A TP   S   PP    A P P  T +  P+++A 
Sbjct: 149 SSVATLAPVNSPAPQDTTAAPPTPSATTPAPPSSSAPPETTAAPPTPSATTQAPPSSSAP 208

Query: 61  HREAAA--VPAAKMPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLP-----PHYTSTAQ 113
               AA   P A  PA  S       ++AP    A PP  S   P P     P  T+   
Sbjct: 209 PETTAAPPTPPATTPAPPS-------SSAPPETTAAPPTPSATTPAPLSSSAPPETTAVP 261

Query: 114 ITVRALGADRLLLHGPDPVPGAAGSAAAPRGRCLLLAPAPAAPVP 158
            T  A   D      P        + AAP          P++P P
Sbjct: 262 PTPSATTLD------PSSASAPPETTAAPPTPSATTPAPPSSPAP 300



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 34/111 (30%), Positives = 45/111 (40%), Gaps = 11/111 (9%)

Query: 5   SSVCTHYPAGAPGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREA 64
           SS      A  P P A  PAPP+++ P + +  PP  +   P P +    P       E 
Sbjct: 205 SSAPPETTAAPPTPPATTPAPPSSSAPPETTAAPPTPSATTPAPLSSSAPP-------ET 257

Query: 65  AAVPAAKMPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLPPHYTSTAQIT 115
            AVP    P  S+     S A+AP    A PP  S   P PP   +  + T
Sbjct: 258 TAVP----PTPSATTLDPSSASAPPETTAAPPTPSATTPAPPSSPAPQETT 304



 Score = 33.5 bits (75), Expect = 0.44
 Identities = 20/56 (35%), Positives = 23/56 (41%)

Query: 13  AGAPGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAVP 68
           A AP  T AAP  P+A TP   S   P    AAP           A +  E +A P
Sbjct: 274 ASAPPETTAAPPTPSATTPAPPSSPAPQETTAAPITTPNSSPTTLAPDTSETSAAP 329



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 28/105 (26%), Positives = 40/105 (38%), Gaps = 18/105 (17%)

Query: 13  AGAPGPTAAAPAPPAAAT--PFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAVPAA 70
           + AP  T A P  P+A T  P   S  PP    A P P      P ++   +E  A P  
Sbjct: 251 SSAPPETTAVPPTPSATTLDPSSASA-PPETTAAPPTPSATTPAPPSSPAPQETTAAP-- 307

Query: 71  KMPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLPPHYTSTAQIT 115
                     + +  ++P + A   P  S     P H T+T+  T
Sbjct: 308 ----------ITTPNSSPTTLA---PDTSETSAAPTHQTTTSVTT 339



 Score = 31.2 bits (69), Expect = 2.2
 Identities = 41/153 (26%), Positives = 48/153 (31%), Gaps = 20/153 (13%)

Query: 133 PGAAGSAAAPRGRCLLLAPAPAAPVPPRRGSSAWLLEELLRPDCPEPAGLDATREGPDRN 192
           P    + AAP        P+   P PP   SS+   E    P  P      AT + P  +
Sbjct: 160 PAPQDTTAAPP------TPSATTPAPP---SSSAPPETTAAPPTPS-----ATTQAPPSS 205

Query: 193 FRLSEHRQALAAAKHRGPAATPGSPDPGPGPWGEEHLAERGPRGWERGGDRCDAPGGDAA 252
               E      AA    PA TP  P     P  E   A   P           AP    A
Sbjct: 206 SAPPE----TTAAPPTPPATTPAPPSSSAPP--ETTAAPPTPSATTPAPLSSSAPPETTA 259

Query: 253 RRPDPEAEAPPAGSIEAAPSSAAEPVIVSRSDP 285
             P P A      S  A P + A P   S + P
Sbjct: 260 VPPTPSATTLDPSSASAPPETTAAPPTPSATTP 292


>gi|222418645 mucin 7, secreted precursor [Homo sapiens]
          Length = 377

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 51/165 (30%), Positives = 63/165 (38%), Gaps = 24/165 (14%)

Query: 5   SSVCTHYPAGAPGP--TAAAPAPPAAATPFKVSLQ-PPGAAGAAPEPE-TGECQPAAAAE 60
           SSV T  P  +P P  T AAP  P+A TP   S   PP    A P P  T +  P+++A 
Sbjct: 149 SSVATLAPVNSPAPQDTTAAPPTPSATTPAPPSSSAPPETTAAPPTPSATTQAPPSSSAP 208

Query: 61  HREAAA--VPAAKMPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLP-----PHYTSTAQ 113
               AA   P A  PA  S       ++AP    A PP  S   P P     P  T+   
Sbjct: 209 PETTAAPPTPPATTPAPPS-------SSAPPETTAAPPTPSATTPAPLSSSAPPETTAVP 261

Query: 114 ITVRALGADRLLLHGPDPVPGAAGSAAAPRGRCLLLAPAPAAPVP 158
            T  A   D      P        + AAP          P++P P
Sbjct: 262 PTPSATTLD------PSSASAPPETTAAPPTPSATTPAPPSSPAP 300



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 34/111 (30%), Positives = 45/111 (40%), Gaps = 11/111 (9%)

Query: 5   SSVCTHYPAGAPGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREA 64
           SS      A  P P A  PAPP+++ P + +  PP  +   P P +    P       E 
Sbjct: 205 SSAPPETTAAPPTPPATTPAPPSSSAPPETTAAPPTPSATTPAPLSSSAPP-------ET 257

Query: 65  AAVPAAKMPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLPPHYTSTAQIT 115
            AVP    P  S+     S A+AP    A PP  S   P PP   +  + T
Sbjct: 258 TAVP----PTPSATTLDPSSASAPPETTAAPPTPSATTPAPPSSPAPQETT 304



 Score = 33.5 bits (75), Expect = 0.44
 Identities = 20/56 (35%), Positives = 23/56 (41%)

Query: 13  AGAPGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAVP 68
           A AP  T AAP  P+A TP   S   P    AAP           A +  E +A P
Sbjct: 274 ASAPPETTAAPPTPSATTPAPPSSPAPQETTAAPITTPNSSPTTLAPDTSETSAAP 329



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 28/105 (26%), Positives = 40/105 (38%), Gaps = 18/105 (17%)

Query: 13  AGAPGPTAAAPAPPAAAT--PFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAVPAA 70
           + AP  T A P  P+A T  P   S  PP    A P P      P ++   +E  A P  
Sbjct: 251 SSAPPETTAVPPTPSATTLDPSSASA-PPETTAAPPTPSATTPAPPSSPAPQETTAAP-- 307

Query: 71  KMPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLPPHYTSTAQIT 115
                     + +  ++P + A   P  S     P H T+T+  T
Sbjct: 308 ----------ITTPNSSPTTLA---PDTSETSAAPTHQTTTSVTT 339



 Score = 31.2 bits (69), Expect = 2.2
 Identities = 41/153 (26%), Positives = 48/153 (31%), Gaps = 20/153 (13%)

Query: 133 PGAAGSAAAPRGRCLLLAPAPAAPVPPRRGSSAWLLEELLRPDCPEPAGLDATREGPDRN 192
           P    + AAP        P+   P PP   SS+   E    P  P      AT + P  +
Sbjct: 160 PAPQDTTAAPP------TPSATTPAPP---SSSAPPETTAAPPTPS-----ATTQAPPSS 205

Query: 193 FRLSEHRQALAAAKHRGPAATPGSPDPGPGPWGEEHLAERGPRGWERGGDRCDAPGGDAA 252
               E      AA    PA TP  P     P  E   A   P           AP    A
Sbjct: 206 SAPPE----TTAAPPTPPATTPAPPSSSAPP--ETTAAPPTPSATTPAPLSSSAPPETTA 259

Query: 253 RRPDPEAEAPPAGSIEAAPSSAAEPVIVSRSDP 285
             P P A      S  A P + A P   S + P
Sbjct: 260 VPPTPSATTLDPSSASAPPETTAAPPTPSATTP 292


>gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]
          Length = 2817

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 53/189 (28%), Positives = 75/189 (39%), Gaps = 12/189 (6%)

Query: 2    QLYSSVCTHYPAGAP-GPTAAAPAPPAAATPFKVSLQPPGAAGAAPEP---------ETG 51
            Q  SS      A AP  P+ +A  P + + P   +L P  A+ +AP P          T 
Sbjct: 1739 QAQSSASVPPLASAPLPPSTSASVPASTSAPLPATLTPVPASTSAPVPASTLAPVLASTS 1798

Query: 52   ECQPAAAAEHREAAAVPAAKMPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLPPHYTST 111
               PA+      A+A  +A +PA +S   + S ++APASA A  P        P   T  
Sbjct: 1799 APVPASPLAPVSASASVSASVPASTSAAAITS-SSAPASAPAPTP-ILASVSTPASVTIL 1856

Query: 112  AQITVRALGADRLLLHGPDPVPGAAGSAAAPRGRCLLLAPAPAAPVPPRRGSSAWLLEEL 171
            A  ++  L +       P P P A+  AA       + A AP A VP    S++      
Sbjct: 1857 ASASIPILASALASTSAPTPAPAASSPAAPVITAPTIPASAPTASVPLAPASASAPAPAP 1916

Query: 172  LRPDCPEPA 180
                 P PA
Sbjct: 1917 TPVSAPNPA 1925



 Score = 37.0 bits (84), Expect = 0.040
 Identities = 30/97 (30%), Positives = 41/97 (42%), Gaps = 5/97 (5%)

Query: 12   PAGAPGPTA--AAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAVPA 69
            PA AP PT   A+ + PA+ T    +  P  A+  A    T    PA AA    A  + A
Sbjct: 1834 PASAPAPTPILASVSTPASVTILASASIPILASALA---STSAPTPAPAASSPAAPVITA 1890

Query: 70   AKMPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLPP 106
              +PA +    V    A+ ++ A  P   S   P PP
Sbjct: 1891 PTIPASAPTASVPLAPASASAPAPAPTPVSAPNPAPP 1927


>gi|148237270 hypermethylated in cancer 1 isoform 2 [Homo sapiens]
          Length = 733

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 74/258 (28%), Positives = 90/258 (34%), Gaps = 56/258 (21%)

Query: 12  PAGAPGPTAAAPAPPAAAT-PFKVSLQPPGAAGAAPEPETG---ECQPAAAAEHREAAAV 67
           P G PG    A  P   A  P  V   PP AA     PE      C    A+    AAA+
Sbjct: 170 PYGRPGRGLRAATPVIQACYPSPVGPPPPPAAEPPSGPEAAVNTHCAELYASGPGPAAAL 229

Query: 68  PAAKMPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLPPHYTSTAQITVRALGADRLLLH 127
            A++      C   +S  + P SAA   P A  +  LPP   S       A     L L 
Sbjct: 230 CASERRCSPLCGLDLSKKSPPGSAAPERPLAERE--LPPRPDSPPSAGPAAYKEPPLALP 287

Query: 128 GPDPVPGAAGSAAAPRGRCLLLAPAPAAPVPPRRGSSAWLLEELLRPDCPEPAGLDATRE 187
              P+P      AAP             P  P RG S            PEP G     +
Sbjct: 288 SLPPLPFQKLEEAAP-------------PSDPFRGGSG--------SPGPEPPGRP---D 323

Query: 188 GPDRNFRLSEHRQALAAAKHRGPAATPGSPDPGPGPWGEEHLAERGPRGWERGGDRCDAP 247
           GP   +R  +H                   +PG G +G+E   ERG        +RC+  
Sbjct: 324 GPSLLYRWMKH-------------------EPGLGSYGDELGRERGSPS-----ERCEER 359

Query: 248 GGDAARRP--DPEAEAPP 263
           GGDAA  P   P   APP
Sbjct: 360 GGDAAVSPGGPPLGLAPP 377


>gi|61676186 hypermethylated in cancer 1 isoform 1 [Homo sapiens]
          Length = 714

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 74/258 (28%), Positives = 90/258 (34%), Gaps = 56/258 (21%)

Query: 12  PAGAPGPTAAAPAPPAAAT-PFKVSLQPPGAAGAAPEPETG---ECQPAAAAEHREAAAV 67
           P G PG    A  P   A  P  V   PP AA     PE      C    A+    AAA+
Sbjct: 151 PYGRPGRGLRAATPVIQACYPSPVGPPPPPAAEPPSGPEAAVNTHCAELYASGPGPAAAL 210

Query: 68  PAAKMPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLPPHYTSTAQITVRALGADRLLLH 127
            A++      C   +S  + P SAA   P A  +  LPP   S       A     L L 
Sbjct: 211 CASERRCSPLCGLDLSKKSPPGSAAPERPLAERE--LPPRPDSPPSAGPAAYKEPPLALP 268

Query: 128 GPDPVPGAAGSAAAPRGRCLLLAPAPAAPVPPRRGSSAWLLEELLRPDCPEPAGLDATRE 187
              P+P      AAP             P  P RG S            PEP G     +
Sbjct: 269 SLPPLPFQKLEEAAP-------------PSDPFRGGSG--------SPGPEPPGRP---D 304

Query: 188 GPDRNFRLSEHRQALAAAKHRGPAATPGSPDPGPGPWGEEHLAERGPRGWERGGDRCDAP 247
           GP   +R  +H                   +PG G +G+E   ERG        +RC+  
Sbjct: 305 GPSLLYRWMKH-------------------EPGLGSYGDELGRERGSPS-----ERCEER 340

Query: 248 GGDAARRP--DPEAEAPP 263
           GGDAA  P   P   APP
Sbjct: 341 GGDAAVSPGGPPLGLAPP 358


>gi|122937267 lemur tyrosine kinase 3 [Homo sapiens]
          Length = 1489

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 80/303 (26%), Positives = 99/303 (32%), Gaps = 59/303 (19%)

Query: 14   GAPGPTAA---APAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAVPAA 70
            G P P  +   APAP A  +        PG  G  P P+ G  +P       E    P A
Sbjct: 1073 GEPAPETSLERAPAPSAVVSSRNGGETAPGPLG--PAPKNGTLEPGTERRAPETGGAPRA 1130

Query: 71   KMPAFSSCFEVVSGAAAPASAAAGPPGA-------------SCKP-PLPPHYTSTAQITV 116
                 +   ++ SG  AP      P G              + +P P PP      +   
Sbjct: 1131 ---PGAGRLDLGSGGRAPVGTGTAPGGGPGSGVDAKAGWVDNTRPQPPPPPLPPPPEAQP 1187

Query: 117  RALGADRLLLHGPDPVPGAAGSAAAPRGRCLLLAPAPAAPVPPRRGSSAWLLEELLRPDC 176
            R L          +P P  A    AP G        P AP     G +A  L     P  
Sbjct: 1188 RRL----------EPAPPRARPEVAPEGE-------PGAPDSRAGGDTA--LSGDGDPPK 1228

Query: 177  PEPAGLDATREGPDRNFRLSEHRQALAAAKHRGPAATP--GSPDPGPG----PWGEEHLA 230
            PE  G +  R   D         Q  A       A  P   +P PGPG    PW     A
Sbjct: 1229 PERKGPEMPRLFLDLGPPQGNSEQIKARLSRLSLALPPLTLTPFPGPGPRRPPW---EGA 1285

Query: 231  ERGPRGWERGGDRCDAPG------GDAARRPDPEAEAPPAGSIEAAPS---SAAEPVIVS 281
            + G  G E GG     P        D     D EA AP A +    P    +A  PV+VS
Sbjct: 1286 DAGAAGGEAGGAGAPGPAEEDGEDEDEDEEEDEEAAAPGAAAGPRGPGRARAAPVPVVVS 1345

Query: 282  RSD 284
             +D
Sbjct: 1346 SAD 1348



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 44/159 (27%), Positives = 54/159 (33%), Gaps = 39/159 (24%)

Query: 66  AVPAAKMPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLPPHYTSTAQITVRALGADRLL 125
           A PA+  P F    + + GAAAP     GPP A   PP PP                   
Sbjct: 752 APPASAPPEF---LDPLMGAAAPQYPGRGPPPAPPPPPPPPR------------------ 790

Query: 126 LHGPDPVPGAAGSAAAPRGRCLLLAPAPAAPVP-PRRGSSAWLLEELLRPDCPEPAGLDA 184
                     A  AA+P     + +P      P P+ G S +  E    P+   P G  A
Sbjct: 791 --------APADPAASPDPPSAVASPGSGLSSPGPKPGDSGYETETPFSPEGAFPGGGAA 842

Query: 185 TREGPDRNFRLSEHRQALAAAKHRGPAATPGSPDPGPGP 223
             EG  R           A  +   P A    PDPGP P
Sbjct: 843 EEEGVPR---------PRAPPEPPDPGAPRPPPDPGPLP 872



 Score = 36.2 bits (82), Expect = 0.068
 Identities = 74/303 (24%), Positives = 96/303 (31%), Gaps = 49/303 (16%)

Query: 23  PAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAVPAAKMPAFSSCFEVV 82
           PA  +A+  F +S   P   GA    ET    PA     R  A       P      E  
Sbjct: 625 PAQSSASGSFLLSGWDPEGRGAG---ETLAGDPAEVLGERGTA-------PWVEEEEEEE 674

Query: 83  SGAAAPASAAAGPPGASCKPPLPPHYTSTAQITVRALGADRLLLHGPDPVPGAAGSAA-- 140
            G++    +++   G S + PLP        +  R      L L   D V G  G  A  
Sbjct: 675 EGSSPGEDSSSLGGGPSRRGPLP------CPLCSREGACSCLPLERGDAVAGWGGHPALG 728

Query: 141 ------------APRGRCLLLAPAPAAPVPPRRGSSAWLLEELLRPDCPEPAGLDATREG 188
                       A RG    L  AP A  PP        L+ L+    P+  G       
Sbjct: 729 CPHPPEDDSSLRAERGSLADLPMAPPASAPPE------FLDPLMGAAAPQYPGRGPPPAP 782

Query: 189 PDRNFRLSEHRQALAAAKHRGPAATPGS----PDPGPGPWGEEHLAERGPRGWERGGDRC 244
           P             A+       A+PGS    P P PG  G E      P G        
Sbjct: 783 PPPPPPPRAPADPAASPDPPSAVASPGSGLSSPGPKPGDSGYETETPFSPEG-------- 834

Query: 245 DAPGGDAARRPD-PEAEAPPAGSIEAAPSSAAEPVIVSRSDPRDEKLALYLAEVEKQDKY 303
             PGG AA     P   APP      AP    +P  +    PR++   +     E+    
Sbjct: 835 AFPGGGAAEEEGVPRPRAPPEPPDPGAPRPPPDPGPLPLPGPREKPTFVVQVSTEQLLMS 894

Query: 304 LRQ 306
           LR+
Sbjct: 895 LRE 897



 Score = 32.7 bits (73), Expect = 0.75
 Identities = 26/91 (28%), Positives = 37/91 (40%), Gaps = 8/91 (8%)

Query: 16  PGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAVPAAKMPAF 75
           P P   APA PAA+     ++  PG+  ++P P+ G+     +    E    P    P  
Sbjct: 785 PPPPPRAPADPAASPDPPSAVASPGSGLSSPGPKPGD-----SGYETETPFSPEGAFPGG 839

Query: 76  SSCFEVVSGAAAPASAAAGP-PGASCKPPLP 105
            +  E   G   P +    P PGA   PP P
Sbjct: 840 GAAEE--EGVPRPRAPPEPPDPGAPRPPPDP 868


>gi|62177127 myosin heavy chain Myr 8 [Homo sapiens]
          Length = 1858

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 82/308 (26%), Positives = 110/308 (35%), Gaps = 68/308 (22%)

Query: 12   PAGAPGPTAAA--PAPPAAATPFKVSLQPPG-----------AAGAAPEPETGECQPAAA 58
            PAGAPG  A    P  P  A P      PPG             G A  P++ +  P  +
Sbjct: 1376 PAGAPGAAARVLTPGTPQCALP---PAAPPGDEDDSEPVYIEMLGHAARPDSPD--PGES 1430

Query: 59   AEHREAAAVPAAKMPAFSSCFEVVSGAA------APASAAAGPPGASC--KPPLP---PH 107
                    +P    P   S   ++ GA+      AP   AAGPPG +C   PP P   PH
Sbjct: 1431 VYEEMKCCLPDDGGPGAGSF--LLHGASPPLLHRAPEDEAAGPPGDACDIPPPFPNLLPH 1488

Query: 108  YTSTAQITVRALGADRLLLHGPDPVPGAAGSAAAPRGRCLLLAPAPAAPVPPRRGSSAWL 167
                            LL+  P PV  +  S  +P      L P     +P    +    
Sbjct: 1489 -------------RPPLLVFPPTPVTCSPASDESP------LTPLEVKKLPVLETN---- 1525

Query: 168  LEELLRPDCPEPAGLDATREGPDRNFRLSEHRQALAAAKHR-GPAATPGSPDPGPGPWGE 226
            L+  ++P+   P     ++       R +    AL     R  P +TP  P P PGP   
Sbjct: 1526 LKYPVQPEGSSPLSPQYSKSQKGDGDRPASPGLALFNGSGRASPPSTPPPPPPPPGPPPA 1585

Query: 227  -----EHLA---ERGPRGWERGGDRCDAPGGDAARRPDPEAEAPPAGSIEAAPSSAAEPV 278
                  HLA   E  P    + G   +AP       P P + AP AG   + P     PV
Sbjct: 1586 PYRPCAHLAFPPEPAPVNAGKAGPSAEAP----KVHPKPNS-APVAGPCSSFPKIPYSPV 1640

Query: 279  IVSRSDPR 286
              +R+D R
Sbjct: 1641 KATRADAR 1648


>gi|169217659 PREDICTED: similar to ectonucleotide
           pyrophosphatase/phosphodiesterase 5 [Homo sapiens]
          Length = 542

 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 77/304 (25%), Positives = 105/304 (34%), Gaps = 86/304 (28%)

Query: 17  GPTAAAPAPPAAATPFKVSLQPPGAA----GAAPEPETGECQ---PAAAAEHREAAAVPA 69
           GP + AP P +A    ++    PG A    G AP P +   Q   P +A  HR A     
Sbjct: 247 GPASRAPNPDSAPPKLRILGPAPGPASEDHGLAPGPSSNPPQLRLPESA--HRLAV---- 300

Query: 70  AKMPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLPPHYTSTAQITVRALGADRLLLHG- 128
                   C+++V+    P   +      SC     PH     Q     L A    L G 
Sbjct: 301 --------CYDIVNAPPLPRLLSPSLGLLSC-----PHARHCLQDATN-LNASEAQLPGS 346

Query: 129 --PDPVPGAAG--------SAAAPRGRCLLLAPAPAAPVPPRRGSSAWLLE------ELL 172
             P P PG A           +APR   L ++P PA  +PPR       L+      ++ 
Sbjct: 347 PYPGPAPGTANLDSPQDLPQQSAPRTHLLTVSPGPAPSLPPRTALGPPPLQSRPGFLQVS 406

Query: 173 RPDC--------PEPAGLDATREGPDRNFRLSEHRQAL-------AAAKHRG-------- 209
           R  C         E AG +   +G +R F  +   ++        A+ + RG        
Sbjct: 407 RQRCGSAHVMAPEENAGTELWLQGFERRFLAARSLRSFPWQVAGGASGEARGGRGSPGAD 466

Query: 210 ----PAATPGSP-------------DPGPGPWGEEHLAE--RGPRGWERGGDRCDAPGGD 250
                A TPG+P              PGP PWG   +A     PR       R   PGG 
Sbjct: 467 GMGLGAETPGAPATCVPGLSPVRAARPGPRPWGLARVARTPSAPRAGGGSWGRLHRPGGQ 526

Query: 251 AARR 254
              R
Sbjct: 527 TRVR 530


>gi|169167316 PREDICTED: similar to ectonucleotide
           pyrophosphatase/phosphodiesterase 5 [Homo sapiens]
          Length = 542

 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 77/304 (25%), Positives = 105/304 (34%), Gaps = 86/304 (28%)

Query: 17  GPTAAAPAPPAAATPFKVSLQPPGAA----GAAPEPETGECQ---PAAAAEHREAAAVPA 69
           GP + AP P +A    ++    PG A    G AP P +   Q   P +A  HR A     
Sbjct: 247 GPASRAPNPDSAPPKLRILGPAPGPASEDHGLAPGPSSNPPQLRLPESA--HRLAV---- 300

Query: 70  AKMPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLPPHYTSTAQITVRALGADRLLLHG- 128
                   C+++V+    P   +      SC     PH     Q     L A    L G 
Sbjct: 301 --------CYDIVNAPPLPRLLSPSLGLLSC-----PHARHCLQDATN-LNASEAQLPGS 346

Query: 129 --PDPVPGAAG--------SAAAPRGRCLLLAPAPAAPVPPRRGSSAWLLE------ELL 172
             P P PG A           +APR   L ++P PA  +PPR       L+      ++ 
Sbjct: 347 PYPGPAPGTANLDSPQDLPQQSAPRTHLLTVSPGPAPSLPPRTALGPPPLQSRPGFLQVS 406

Query: 173 RPDC--------PEPAGLDATREGPDRNFRLSEHRQAL-------AAAKHRG-------- 209
           R  C         E AG +   +G +R F  +   ++        A+ + RG        
Sbjct: 407 RQRCGSAHVMAPEENAGTELWLQGFERRFLAARSLRSFPWQVAGGASGEARGGRGSPGAD 466

Query: 210 ----PAATPGSP-------------DPGPGPWGEEHLAE--RGPRGWERGGDRCDAPGGD 250
                A TPG+P              PGP PWG   +A     PR       R   PGG 
Sbjct: 467 GMGLGAETPGAPATCVPGLSPVRAARPGPRPWGLARVARTPSAPRAGGGSWGRLHRPGGQ 526

Query: 251 AARR 254
              R
Sbjct: 527 TRVR 530


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.132    0.413 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,753,613
Number of Sequences: 37866
Number of extensions: 1703965
Number of successful extensions: 15022
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 156
Number of HSP's successfully gapped in prelim test: 1150
Number of HSP's that attempted gapping in prelim test: 9811
Number of HSP's gapped (non-prelim): 4725
length of query: 481
length of database: 18,247,518
effective HSP length: 106
effective length of query: 375
effective length of database: 14,233,722
effective search space: 5337645750
effective search space used: 5337645750
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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