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Search of human proteins with 22208955
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22208955 ankyrin repeat and SOCS box-containing protein 12
[Homo sapiens]
(309 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22208955 ankyrin repeat and SOCS box-containing protein 12 [H... 622 e-178
gi|94721248 ankyrin repeat and SOCS box-containing protein 1 [Ho... 188 6e-48
gi|18254476 ankyrin repeat and SOCS box-containing protein 5 [Ho... 94 1e-19
gi|18254474 ankyrin repeat and SOCS box-containing protein 11 is... 88 1e-17
gi|60218887 ankyrin repeat and SOCS box-containing protein 11 is... 88 1e-17
gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isof... 88 1e-17
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 87 1e-17
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 87 1e-17
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 87 1e-17
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 87 1e-17
gi|72534772 ankyrin repeat and SOCS box-containing 9 isoform 1 [... 86 3e-17
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 86 5e-17
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 86 5e-17
gi|22208957 ankyrin repeat and SOCS box-containing protein 13 [H... 85 9e-17
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 84 1e-16
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 84 1e-16
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 84 1e-16
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 84 1e-16
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 84 1e-16
gi|13443014 ankyrin repeat and SOCS box-containing 9 isoform 2 [... 79 7e-15
gi|22208951 ankyrin repeat and SOCS box-containing protein 3 iso... 79 7e-15
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 75 7e-14
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 75 7e-14
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 75 7e-14
gi|34304381 inversin isoform a [Homo sapiens] 74 1e-13
gi|34304379 inversin isoform b [Homo sapiens] 74 1e-13
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 74 2e-13
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 73 3e-13
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 72 6e-13
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 70 2e-12
>gi|22208955 ankyrin repeat and SOCS box-containing protein 12 [Homo
sapiens]
Length = 309
Score = 622 bits (1603), Expect = e-178
Identities = 309/309 (100%), Positives = 309/309 (100%)
Query: 1 MNLMDITKIFSLLQPDKEEEDTDTEEKQALNQAVYDNDSYTLDQLLRQERYKRFINSRSG 60
MNLMDITKIFSLLQPDKEEEDTDTEEKQALNQAVYDNDSYTLDQLLRQERYKRFINSRSG
Sbjct: 1 MNLMDITKIFSLLQPDKEEEDTDTEEKQALNQAVYDNDSYTLDQLLRQERYKRFINSRSG 60
Query: 61 WGVPGTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAG 120
WGVPGTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAG
Sbjct: 61 WGVPGTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAG 120
Query: 121 ASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAA 180
ASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAA
Sbjct: 121 ASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAA 180
Query: 181 VYGHLDCFRLLLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNCEPEYIQLLIDFGAN 240
VYGHLDCFRLLLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNCEPEYIQLLIDFGAN
Sbjct: 181 VYGHLDCFRLLLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNCEPEYIQLLIDFGAN 240
Query: 241 IYLPSLSLDLTSQDDKGIALLLQARATPRSLLSQVRLVVRRALCQAGQPQAINQLDIPPM 300
IYLPSLSLDLTSQDDKGIALLLQARATPRSLLSQVRLVVRRALCQAGQPQAINQLDIPPM
Sbjct: 241 IYLPSLSLDLTSQDDKGIALLLQARATPRSLLSQVRLVVRRALCQAGQPQAINQLDIPPM 300
Query: 301 LISYLKHQL 309
LISYLKHQL
Sbjct: 301 LISYLKHQL 309
>gi|94721248 ankyrin repeat and SOCS box-containing protein 1 [Homo
sapiens]
Length = 335
Score = 188 bits (477), Expect = 6e-48
Identities = 119/302 (39%), Positives = 175/302 (57%), Gaps = 22/302 (7%)
Query: 26 EKQALNQAVYDNDSYTLDQLLRQERYKRFINSRSGW---GVPGTPLRLAASYGHLSCLQV 82
E L+ A Y D TL LL++E Y+ IN +S W +P TPLR+AA+ GH SC+
Sbjct: 37 EDTRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDF 96
Query: 83 LLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNCSPVLTAARDGA 142
L+ GA+VD +DVK QT L+ AV +GHL+ ++LLEAGA P GS ++ +PV A+R G
Sbjct: 97 LIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGR 156
Query: 143 VAILQELLDHGAEANVKAKL-----PVWASNIAS-CSGPLYLAAVYGHLDCFRLLLLHGA 196
IL+ L+ +GA+ +V L P ++ + S PLY++A Y +L CFRLLLL GA
Sbjct: 157 ADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGA 216
Query: 197 DPDYNC----TDQGLLARVPRPRTLLEICLHHNCEPEYIQLLIDFGANIYLPSL-SLDLT 251
+PD+NC QG P +++ L H CE ++ LL++FGAN+ L SL
Sbjct: 217 NPDFNCNGPVNTQGFYR--GSPGCVMDAVLRHGCEAAFVSLLVEFGANLNLVKWESLGPE 274
Query: 252 SQ-----DDKGIALLLQARATPRSLLSQVRLVVRRALCQAGQPQAINQLDIPPMLISYLK 306
S+ D + + + +AR+ PR+LL R+ VRRAL + + I L +P + +L
Sbjct: 275 SRGRRKVDPEALQVFKEARSVPRTLLCLCRVAVRRALGK-HRLHLIPSLPLPDPIKKFLL 333
Query: 307 HQ 308
H+
Sbjct: 334 HE 335
>gi|18254476 ankyrin repeat and SOCS box-containing protein 5 [Homo
sapiens]
Length = 329
Score = 94.4 bits (233), Expect = 1e-19
Identities = 78/271 (28%), Positives = 128/271 (47%), Gaps = 41/271 (15%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
+PL AAS G L L+ LL+ G +V+++ + TPL A H+ C R LLEAGA+
Sbjct: 72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+ +P+ A G+ + + LL++GA+A +++ LP P + AA GH
Sbjct: 132 ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP----------SPTHEAASKGHH 181
Query: 186 DCFRLLLLHGADPD------------------YNCTDQGLLARVPRPR-TLLEICLH--- 223
+C +L+ G D D ++C + L A + + LH
Sbjct: 182 ECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGKYWDTPLHAAA 241
Query: 224 HNCEPEYIQLLIDFGANIYLPSLSL----DLTSQDDKGIALLLQARATPRSLLSQVRLVV 279
E + LL++FGA+I + L D+ + +LLQ ATP SL RL +
Sbjct: 242 QQSSTEIVNLLLEFGADINAKNTELLRPIDVATSSSMVERILLQHEATPSSLYQLCRLCI 301
Query: 280 RRALCQAGQPQ--AINQLDIPPMLISYLKHQ 308
R + G+P+ I QL +P +L ++L+++
Sbjct: 302 RSYI---GKPRLHLIPQLQLPTLLKNFLQYR 329
Score = 33.9 bits (76), Expect = 0.19
Identities = 29/90 (32%), Positives = 35/90 (38%), Gaps = 3/90 (3%)
Query: 65 GTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPG 124
GTPL +A C+ LL GADV TPL A + V +LLE GA
Sbjct: 202 GTPLYVACMSQQFHCIWKLLYAGADVQK-GKYWDTPLHAAAQQSSTEIVNLLLEFGADIN 260
Query: 125 GSIYNNCSPVLTAARDGAVAILQELLDHGA 154
P+ A V + LL H A
Sbjct: 261 AKNTELLRPIDVATSSSMVERI--LLQHEA 288
>gi|18254474 ankyrin repeat and SOCS box-containing protein 11
isoform a [Homo sapiens]
Length = 323
Score = 87.8 bits (216), Expect = 1e-17
Identities = 77/269 (28%), Positives = 121/269 (44%), Gaps = 38/269 (14%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
+PL AA+ G L L+ L+A G +V+ + + + L A GH+ C + LLE GA G
Sbjct: 67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 126
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+ +P+ A G+ A + LL+ GA+A ++ L + P++ A GH
Sbjct: 127 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHL----------ASPIHEAVKRGHR 176
Query: 186 DCFRLLLLHGADPDYNCTDQG-------LLARVPRPRTLLEI------------CLH--- 223
+C +LL + + D+ G RV + LLE+ LH
Sbjct: 177 ECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAA 236
Query: 224 HNCEPEYIQLLIDFGANIYLPSL----SLDLTSQDDKGIALLLQARATPRSLLSQVRLVV 279
E I LL D+GAN+ + +LDL + + L R P +L RL V
Sbjct: 237 RQSNVEVIHLLTDYGANLKRRNAQGKSALDLAA-PKSSVEQALLLREGPPALSQLCRLCV 295
Query: 280 RRALCQAGQPQAINQLDIPPMLISYLKHQ 308
R+ L +A QAI++L +P L +L +Q
Sbjct: 296 RKCLGRACH-QAIHKLHLPEPLERFLLYQ 323
Score = 37.0 bits (84), Expect = 0.022
Identities = 20/58 (34%), Positives = 32/58 (55%), Gaps = 1/58 (1%)
Query: 65 GTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGAS 122
GTPL +A +Y + C++ LL GA VD TPL A +++ + +L + GA+
Sbjct: 197 GTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVIHLLTDYGAN 253
>gi|60218887 ankyrin repeat and SOCS box-containing protein 11
isoform b [Homo sapiens]
Length = 302
Score = 87.8 bits (216), Expect = 1e-17
Identities = 77/269 (28%), Positives = 121/269 (44%), Gaps = 38/269 (14%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
+PL AA+ G L L+ L+A G +V+ + + + L A GH+ C + LLE GA G
Sbjct: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+ +P+ A G+ A + LL+ GA+A ++ L + P++ A GH
Sbjct: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHL----------ASPIHEAVKRGHR 155
Query: 186 DCFRLLLLHGADPDYNCTDQG-------LLARVPRPRTLLEI------------CLH--- 223
+C +LL + + D+ G RV + LLE+ LH
Sbjct: 156 ECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAA 215
Query: 224 HNCEPEYIQLLIDFGANIYLPSL----SLDLTSQDDKGIALLLQARATPRSLLSQVRLVV 279
E I LL D+GAN+ + +LDL + + L R P +L RL V
Sbjct: 216 RQSNVEVIHLLTDYGANLKRRNAQGKSALDLAA-PKSSVEQALLLREGPPALSQLCRLCV 274
Query: 280 RRALCQAGQPQAINQLDIPPMLISYLKHQ 308
R+ L +A QAI++L +P L +L +Q
Sbjct: 275 RKCLGRACH-QAIHKLHLPEPLERFLLYQ 302
Score = 37.0 bits (84), Expect = 0.022
Identities = 20/58 (34%), Positives = 32/58 (55%), Gaps = 1/58 (1%)
Query: 65 GTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGAS 122
GTPL +A +Y + C++ LL GA VD TPL A +++ + +L + GA+
Sbjct: 176 GTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVIHLLTDYGAN 232
>gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isoform
a [Homo sapiens]
Length = 518
Score = 87.8 bits (216), Expect = 1e-17
Identities = 65/228 (28%), Positives = 101/228 (44%), Gaps = 47/228 (20%)
Query: 12 LLQPDKEEEDTDTEEKQALNQAVYDNDSYTLDQLLRQERYKRFINSRSGWGVPGTPLRLA 71
LL+ + + D +++A Y N L L+ + + +I ++ G L LA
Sbjct: 29 LLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKTFEGF--CALHLA 86
Query: 72 ASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNC 131
AS GH +Q+LL GAD ++ ++ TPLF AV +G +D +R+LL+ GA+ GS ++ C
Sbjct: 87 ASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGS-HSMC 145
Query: 132 -----------------------------------SPVLTAARDGAVAILQELLDHGAEA 156
+P+ AA+ G + L L+ GA
Sbjct: 146 GWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANV 205
Query: 157 NVKAKLPVWASNIASCSGPLYLAAVYGHLDCFRLLLLHGADPDYNCTD 204
N +A + PL++AA GH C LLL GADPD C +
Sbjct: 206 NCQA---------LDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNE 244
Score = 76.3 bits (186), Expect = 3e-14
Identities = 59/180 (32%), Positives = 87/180 (48%), Gaps = 30/180 (16%)
Query: 29 ALNQAVYDNDSYTLDQLLRQERYKRFINSRSGWGVPGTPLRLAASYGHLSCLQVLLAHGA 88
+L+QA + ++ + LLR+ K + +G+ TPL +AA YG L L +L++ GA
Sbjct: 149 SLHQASFQENAEIIKLLLRKGANKE---CQDDFGI--TPLFVAAQYGKLESLSILISSGA 203
Query: 89 DVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNCS----PVLTAARDGAVA 144
+V+ + TPLF A GH CV +LL +GA P +Y N P+ AA+ G
Sbjct: 204 NVNCQALDKATPLFIAAQEGHTKCVELLLSSGADP--DLYCNEDSWQLPIHAAAQMGHTK 261
Query: 145 ILQELLDHGAEANVKAKLPVWASNIASCSG-----PLYLAAVYGHLDCFRLLLLHGADPD 199
IL L+ +N A +G P+Y A GH DC +LL +G PD
Sbjct: 262 ILDLLIP--------------LTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPD 307
Score = 34.3 bits (77), Expect = 0.14
Identities = 36/140 (25%), Positives = 60/140 (42%), Gaps = 37/140 (26%)
Query: 129 NNCSPVLTAARDGAVAILQELLDHGAEANV---KAKLPVWAS---NIASCSG-------- 174
+ CS V AAR+G V +L++LL G +V + +P+ + N C
Sbjct: 9 DTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSS 68
Query: 175 -------------PLYLAAVYGHLDCFRLLLLHGADPDYNCTDQGLLARVPRPRTLLEIC 221
L+LAA GH ++LL GADP+ ++ T L +
Sbjct: 69 ENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEE---------TTPLFLA 119
Query: 222 LHHNCEPEYIQLLIDFGANI 241
+ N + + ++LL+ GAN+
Sbjct: 120 V-ENGQIDVLRLLLQHGANV 138
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 87.4 bits (215), Expect = 1e-17
Identities = 78/245 (31%), Positives = 114/245 (46%), Gaps = 22/245 (8%)
Query: 5 DITKIFSLLQPDKEEEDTDTEEKQALNQAVYDNDSYTLDQLLRQERYKRFINSRSGWGVP 64
D+ + LL + + TEE ++L Y L Q+L + R G
Sbjct: 217 DVNAVRKLLDEGRSVNE-HTEEGESLLCLACSAGYYELAQVLLAMHAN--VEDRGNKG-D 272
Query: 65 GTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPG 124
TPL A+S G+L +++LL H ADV+S T L A + G +D V+VLL GA+
Sbjct: 273 ITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIE 332
Query: 125 GSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGH 184
N +P++ AA G V + + LLDHGA N + L LA GH
Sbjct: 333 DHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN--------EFKESALTLACYKGH 384
Query: 185 LDCFRLLLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNCEPEYIQLLIDFGANIYLP 244
LD R LL GAD ++ TD+ A L+E C+ + E +LL+D GA + +P
Sbjct: 385 LDMVRFLLEAGADQEHK-TDEMHTA-------LMEACMDGHV--EVARLLLDSGAQVNMP 434
Query: 245 SLSLD 249
+ S +
Sbjct: 435 ADSFE 439
Score = 75.9 bits (185), Expect = 4e-14
Identities = 62/177 (35%), Positives = 86/177 (48%), Gaps = 20/177 (11%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVK-AQTPLFTAVSHGHLDCVRVLLEAGASPG 124
TPL AAS GH+ +VLL HGA +++ + ++ L A GHLD VR LLEAGA
Sbjct: 340 TPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE 399
Query: 125 GSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGH 184
+ ++ A DG V + + LLD GA+ N+ A S PL LAA GH
Sbjct: 400 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD---------SFESPLTLAACGGH 450
Query: 185 LDCFRLLLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNCEPEYIQLLIDFGANI 241
++ LL+ GA+ + D+G + R E E + LL+ GANI
Sbjct: 451 VELAALLIERGANLE-EVNDEGYTPLMEAAREGHE---------EMVALLLAQGANI 497
Score = 58.2 bits (139), Expect = 9e-09
Identities = 52/190 (27%), Positives = 81/190 (42%), Gaps = 24/190 (12%)
Query: 12 LLQPDKEEEDTDTEEKQALNQAVYDNDSYTLDQLLRQERYKRFINSRSGWGVPG----TP 67
LL+ ++E E AL +A D E + ++S + +P +P
Sbjct: 391 LLEAGADQEHKTDEMHTALMEACMDG---------HVEVARLLLDSGAQVNMPADSFESP 441
Query: 68 LRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSI 127
L LAA GH+ +L+ GA+++ ++ + TPL A GH + V +LL GA+
Sbjct: 442 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 501
Query: 128 YNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDC 187
LT A G E+ D +A +L CS PL A+ GHL+
Sbjct: 502 EETQETALTLACCGG---FSEVADFLIKAGADIEL--------GCSTPLMEASQEGHLEL 550
Query: 188 FRLLLLHGAD 197
+ LL GA+
Sbjct: 551 VKYLLASGAN 560
Score = 46.2 bits (108), Expect = 4e-05
Identities = 25/56 (44%), Positives = 32/56 (57%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGA 121
TPL A+ GHL ++ LLA GA+V + T L A +GH D VLL+AGA
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGA 592
Score = 40.8 bits (94), Expect = 0.002
Identities = 27/90 (30%), Positives = 41/90 (45%), Gaps = 3/90 (3%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
T L LA G L+ GAD++ + TPL A GHL+ V+ LL +GA+
Sbjct: 507 TALTLACCGGFSEVADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLLASGANVHA 563
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAE 155
+ + + A +G + LL GA+
Sbjct: 564 TTATGDTALTYACENGHTDVADVLLQAGAD 593
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 87.4 bits (215), Expect = 1e-17
Identities = 78/245 (31%), Positives = 114/245 (46%), Gaps = 22/245 (8%)
Query: 5 DITKIFSLLQPDKEEEDTDTEEKQALNQAVYDNDSYTLDQLLRQERYKRFINSRSGWGVP 64
D+ + LL + + TEE ++L Y L Q+L + R G
Sbjct: 206 DVNAVRKLLDEGRSVNE-HTEEGESLLCLACSAGYYELAQVLLAMHAN--VEDRGNKG-D 261
Query: 65 GTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPG 124
TPL A+S G+L +++LL H ADV+S T L A + G +D V+VLL GA+
Sbjct: 262 ITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIE 321
Query: 125 GSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGH 184
N +P++ AA G V + + LLDHGA N + L LA GH
Sbjct: 322 DHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN--------EFKESALTLACYKGH 373
Query: 185 LDCFRLLLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNCEPEYIQLLIDFGANIYLP 244
LD R LL GAD ++ TD+ A L+E C+ + E +LL+D GA + +P
Sbjct: 374 LDMVRFLLEAGADQEHK-TDEMHTA-------LMEACMDGHV--EVARLLLDSGAQVNMP 423
Query: 245 SLSLD 249
+ S +
Sbjct: 424 ADSFE 428
Score = 75.9 bits (185), Expect = 4e-14
Identities = 62/177 (35%), Positives = 86/177 (48%), Gaps = 20/177 (11%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVK-AQTPLFTAVSHGHLDCVRVLLEAGASPG 124
TPL AAS GH+ +VLL HGA +++ + ++ L A GHLD VR LLEAGA
Sbjct: 329 TPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE 388
Query: 125 GSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGH 184
+ ++ A DG V + + LLD GA+ N+ A S PL LAA GH
Sbjct: 389 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD---------SFESPLTLAACGGH 439
Query: 185 LDCFRLLLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNCEPEYIQLLIDFGANI 241
++ LL+ GA+ + D+G + R E E + LL+ GANI
Sbjct: 440 VELAALLIERGANLE-EVNDEGYTPLMEAAREGHE---------EMVALLLAQGANI 486
Score = 58.2 bits (139), Expect = 9e-09
Identities = 52/190 (27%), Positives = 81/190 (42%), Gaps = 24/190 (12%)
Query: 12 LLQPDKEEEDTDTEEKQALNQAVYDNDSYTLDQLLRQERYKRFINSRSGWGVPG----TP 67
LL+ ++E E AL +A D E + ++S + +P +P
Sbjct: 380 LLEAGADQEHKTDEMHTALMEACMDG---------HVEVARLLLDSGAQVNMPADSFESP 430
Query: 68 LRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSI 127
L LAA GH+ +L+ GA+++ ++ + TPL A GH + V +LL GA+
Sbjct: 431 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 490
Query: 128 YNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDC 187
LT A G E+ D +A +L CS PL A+ GHL+
Sbjct: 491 EETQETALTLACCGG---FSEVADFLIKAGADIEL--------GCSTPLMEASQEGHLEL 539
Query: 188 FRLLLLHGAD 197
+ LL GA+
Sbjct: 540 VKYLLASGAN 549
Score = 46.2 bits (108), Expect = 4e-05
Identities = 25/56 (44%), Positives = 32/56 (57%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGA 121
TPL A+ GHL ++ LLA GA+V + T L A +GH D VLL+AGA
Sbjct: 526 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGA 581
Score = 40.8 bits (94), Expect = 0.002
Identities = 27/90 (30%), Positives = 41/90 (45%), Gaps = 3/90 (3%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
T L LA G L+ GAD++ + TPL A GHL+ V+ LL +GA+
Sbjct: 496 TALTLACCGGFSEVADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLLASGANVHA 552
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAE 155
+ + + A +G + LL GA+
Sbjct: 553 TTATGDTALTYACENGHTDVADVLLQAGAD 582
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 87.4 bits (215), Expect = 1e-17
Identities = 78/245 (31%), Positives = 114/245 (46%), Gaps = 22/245 (8%)
Query: 5 DITKIFSLLQPDKEEEDTDTEEKQALNQAVYDNDSYTLDQLLRQERYKRFINSRSGWGVP 64
D+ + LL + + TEE ++L Y L Q+L + R G
Sbjct: 217 DVNAVRKLLDEGRSVNE-HTEEGESLLCLACSAGYYELAQVLLAMHAN--VEDRGNKG-D 272
Query: 65 GTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPG 124
TPL A+S G+L +++LL H ADV+S T L A + G +D V+VLL GA+
Sbjct: 273 ITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIE 332
Query: 125 GSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGH 184
N +P++ AA G V + + LLDHGA N + L LA GH
Sbjct: 333 DHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN--------EFKESALTLACYKGH 384
Query: 185 LDCFRLLLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNCEPEYIQLLIDFGANIYLP 244
LD R LL GAD ++ TD+ A L+E C+ + E +LL+D GA + +P
Sbjct: 385 LDMVRFLLEAGADQEHK-TDEMHTA-------LMEACMDGHV--EVARLLLDSGAQVNMP 434
Query: 245 SLSLD 249
+ S +
Sbjct: 435 ADSFE 439
Score = 75.9 bits (185), Expect = 4e-14
Identities = 62/177 (35%), Positives = 86/177 (48%), Gaps = 20/177 (11%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVK-AQTPLFTAVSHGHLDCVRVLLEAGASPG 124
TPL AAS GH+ +VLL HGA +++ + ++ L A GHLD VR LLEAGA
Sbjct: 340 TPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE 399
Query: 125 GSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGH 184
+ ++ A DG V + + LLD GA+ N+ A S PL LAA GH
Sbjct: 400 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD---------SFESPLTLAACGGH 450
Query: 185 LDCFRLLLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNCEPEYIQLLIDFGANI 241
++ LL+ GA+ + D+G + R E E + LL+ GANI
Sbjct: 451 VELAALLIERGANLE-EVNDEGYTPLMEAAREGHE---------EMVALLLAQGANI 497
Score = 73.9 bits (180), Expect = 2e-13
Identities = 51/139 (36%), Positives = 68/139 (48%), Gaps = 8/139 (5%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL A+ GHL ++ LLA GA+V + T L A +GH D VLL+AGA
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 596
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+P++ AAR G + +Q L+ GA N A+N + + LA GHL
Sbjct: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVN-----RATANNDHTV---VSLACAGGHL 648
Query: 186 DCFRLLLLHGADPDYNCTD 204
LLL HGADP + D
Sbjct: 649 AVVELLLAHGADPTHRLKD 667
Score = 62.0 bits (149), Expect = 6e-10
Identities = 53/175 (30%), Positives = 82/175 (46%), Gaps = 33/175 (18%)
Query: 55 INSRSGWGVPGTPLRLAASYGHLSCLQVLLAHGADVDS-LDVKAQTPLFTAVSHGHLDCV 113
INSR+G + +PL LAA GH+ +++LL G+D+++ ++ T L A G + V
Sbjct: 1181 INSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVV 1240
Query: 114 RVLLEAGASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWAS-----N 168
+LL+ A+ +P++ AA G + + LLD GA+ N PV +S
Sbjct: 1241 SLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP---PVPSSRDTALT 1297
Query: 169 IASCSG------------------------PLYLAAVYGHLDCFRLLLLHGADPD 199
IA+ G PL+LA+ GH D +LL+ GAD D
Sbjct: 1298 IAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVD 1352
Score = 59.7 bits (143), Expect = 3e-09
Identities = 46/138 (33%), Positives = 72/138 (52%), Gaps = 12/138 (8%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGA---S 122
TPL LA S G + +LLA GA+ + +V TPL A S G+++ +++LL AGA S
Sbjct: 1124 TPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINS 1183
Query: 123 PGGSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVY 182
GS SP++ AA +G V ++ LLD G++ N + + + + L LA
Sbjct: 1184 RTGSKL-GISPLMLAAMNGHVPAVKLLLDMGSDINAQIE--------TNRNTALTLACFQ 1234
Query: 183 GHLDCFRLLLLHGADPDY 200
G + LLL A+ ++
Sbjct: 1235 GRAEVVSLLLDRKANVEH 1252
Score = 59.3 bits (142), Expect = 4e-09
Identities = 30/85 (35%), Positives = 50/85 (58%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
T L +AA GH ++L+ GA +D + K TPL+ A + GH D V++L++AGA
Sbjct: 1294 TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA 1353
Query: 126 SIYNNCSPVLTAARDGAVAILQELL 150
+ +P+++A R G V ++Q L+
Sbjct: 1354 ADNRKITPLMSAFRKGHVKVVQYLV 1378
Score = 58.9 bits (141), Expect = 5e-09
Identities = 60/210 (28%), Positives = 86/210 (40%), Gaps = 50/210 (23%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAG----- 120
T L LA + GH + VL+A A ++ D K TPL A + GH+ V +LL+ G
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
Query: 121 ------------ASPGG--------------SIYNNCS---PVLTAARDGAVAILQELLD 151
A GG + N S P+ AA G V I++ LL+
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176
Query: 152 HGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDCFRLLLLHGADPDYNCTDQGLLARV 211
GAE N + + S PL LAA+ GH+ +LLL G+D + A++
Sbjct: 1177 AGAEINSRTGSKLGIS-------PLMLAAMNGHVPAVKLLLDMGSD---------INAQI 1220
Query: 212 PRPRTLLEICLHHNCEPEYIQLLIDFGANI 241
R E + LL+D AN+
Sbjct: 1221 ETNRNTALTLACFQGRAEVVSLLLDRKANV 1250
Score = 58.2 bits (139), Expect = 9e-09
Identities = 52/190 (27%), Positives = 81/190 (42%), Gaps = 24/190 (12%)
Query: 12 LLQPDKEEEDTDTEEKQALNQAVYDNDSYTLDQLLRQERYKRFINSRSGWGVPG----TP 67
LL+ ++E E AL +A D E + ++S + +P +P
Sbjct: 391 LLEAGADQEHKTDEMHTALMEACMDG---------HVEVARLLLDSGAQVNMPADSFESP 441
Query: 68 LRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSI 127
L LAA GH+ +L+ GA+++ ++ + TPL A GH + V +LL GA+
Sbjct: 442 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 501
Query: 128 YNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDC 187
LT A G E+ D +A +L CS PL A+ GHL+
Sbjct: 502 EETQETALTLACCGG---FSEVADFLIKAGADIEL--------GCSTPLMEASQEGHLEL 550
Query: 188 FRLLLLHGAD 197
+ LL GA+
Sbjct: 551 VKYLLASGAN 560
Score = 48.5 bits (114), Expect = 7e-06
Identities = 30/88 (34%), Positives = 47/88 (53%), Gaps = 1/88 (1%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQ-TPLFTAVSHGHLDCVRVLLEAGASPG 124
TPL AA GHL +Q L++ GA+V+ T + A + GHL V +LL GA P
Sbjct: 603 TPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPT 662
Query: 125 GSIYNNCSPVLTAARDGAVAILQELLDH 152
+ + + ++ AA+ G ++ LLD+
Sbjct: 663 HRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
Score = 47.0 bits (110), Expect = 2e-05
Identities = 23/53 (43%), Positives = 35/53 (66%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLE 118
TPL LA++ GH +Q+L+ GADVD+ D + TPL +A GH+ V+ L++
Sbjct: 1327 TPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 87.4 bits (215), Expect = 1e-17
Identities = 78/245 (31%), Positives = 114/245 (46%), Gaps = 22/245 (8%)
Query: 5 DITKIFSLLQPDKEEEDTDTEEKQALNQAVYDNDSYTLDQLLRQERYKRFINSRSGWGVP 64
D+ + LL + + TEE ++L Y L Q+L + R G
Sbjct: 217 DVNAVRKLLDEGRSVNE-HTEEGESLLCLACSAGYYELAQVLLAMHAN--VEDRGNKG-D 272
Query: 65 GTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPG 124
TPL A+S G+L +++LL H ADV+S T L A + G +D V+VLL GA+
Sbjct: 273 ITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIE 332
Query: 125 GSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGH 184
N +P++ AA G V + + LLDHGA N + L LA GH
Sbjct: 333 DHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN--------EFKESALTLACYKGH 384
Query: 185 LDCFRLLLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNCEPEYIQLLIDFGANIYLP 244
LD R LL GAD ++ TD+ A L+E C+ + E +LL+D GA + +P
Sbjct: 385 LDMVRFLLEAGADQEHK-TDEMHTA-------LMEACMDGHV--EVARLLLDSGAQVNMP 434
Query: 245 SLSLD 249
+ S +
Sbjct: 435 ADSFE 439
Score = 75.9 bits (185), Expect = 4e-14
Identities = 62/177 (35%), Positives = 86/177 (48%), Gaps = 20/177 (11%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVK-AQTPLFTAVSHGHLDCVRVLLEAGASPG 124
TPL AAS GH+ +VLL HGA +++ + ++ L A GHLD VR LLEAGA
Sbjct: 340 TPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE 399
Query: 125 GSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGH 184
+ ++ A DG V + + LLD GA+ N+ A S PL LAA GH
Sbjct: 400 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD---------SFESPLTLAACGGH 450
Query: 185 LDCFRLLLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNCEPEYIQLLIDFGANI 241
++ LL+ GA+ + D+G + R E E + LL+ GANI
Sbjct: 451 VELAALLIERGANLE-EVNDEGYTPLMEAAREGHE---------EMVALLLAQGANI 497
Score = 73.9 bits (180), Expect = 2e-13
Identities = 51/139 (36%), Positives = 68/139 (48%), Gaps = 8/139 (5%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL A+ GHL ++ LLA GA+V + T L A +GH D VLL+AGA
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 596
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+P++ AAR G + +Q L+ GA N A+N + + LA GHL
Sbjct: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVN-----RATANNDHTV---VSLACAGGHL 648
Query: 186 DCFRLLLLHGADPDYNCTD 204
LLL HGADP + D
Sbjct: 649 AVVELLLAHGADPTHRLKD 667
Score = 62.0 bits (149), Expect = 6e-10
Identities = 53/175 (30%), Positives = 82/175 (46%), Gaps = 33/175 (18%)
Query: 55 INSRSGWGVPGTPLRLAASYGHLSCLQVLLAHGADVDS-LDVKAQTPLFTAVSHGHLDCV 113
INSR+G + +PL LAA GH+ +++LL G+D+++ ++ T L A G + V
Sbjct: 1181 INSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVV 1240
Query: 114 RVLLEAGASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWAS-----N 168
+LL+ A+ +P++ AA G + + LLD GA+ N PV +S
Sbjct: 1241 SLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP---PVPSSRDTALT 1297
Query: 169 IASCSG------------------------PLYLAAVYGHLDCFRLLLLHGADPD 199
IA+ G PL+LA+ GH D +LL+ GAD D
Sbjct: 1298 IAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVD 1352
Score = 59.7 bits (143), Expect = 3e-09
Identities = 46/138 (33%), Positives = 72/138 (52%), Gaps = 12/138 (8%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGA---S 122
TPL LA S G + +LLA GA+ + +V TPL A S G+++ +++LL AGA S
Sbjct: 1124 TPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINS 1183
Query: 123 PGGSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVY 182
GS SP++ AA +G V ++ LLD G++ N + + + + L LA
Sbjct: 1184 RTGSKL-GISPLMLAAMNGHVPAVKLLLDMGSDINAQIE--------TNRNTALTLACFQ 1234
Query: 183 GHLDCFRLLLLHGADPDY 200
G + LLL A+ ++
Sbjct: 1235 GRAEVVSLLLDRKANVEH 1252
Score = 59.3 bits (142), Expect = 4e-09
Identities = 30/85 (35%), Positives = 50/85 (58%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
T L +AA GH ++L+ GA +D + K TPL+ A + GH D V++L++AGA
Sbjct: 1294 TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA 1353
Query: 126 SIYNNCSPVLTAARDGAVAILQELL 150
+ +P+++A R G V ++Q L+
Sbjct: 1354 ADNRKITPLMSAFRKGHVKVVQYLV 1378
Score = 58.9 bits (141), Expect = 5e-09
Identities = 60/210 (28%), Positives = 86/210 (40%), Gaps = 50/210 (23%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAG----- 120
T L LA + GH + VL+A A ++ D K TPL A + GH+ V +LL+ G
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
Query: 121 ------------ASPGG--------------SIYNNCS---PVLTAARDGAVAILQELLD 151
A GG + N S P+ AA G V I++ LL+
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176
Query: 152 HGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDCFRLLLLHGADPDYNCTDQGLLARV 211
GAE N + + S PL LAA+ GH+ +LLL G+D + A++
Sbjct: 1177 AGAEINSRTGSKLGIS-------PLMLAAMNGHVPAVKLLLDMGSD---------INAQI 1220
Query: 212 PRPRTLLEICLHHNCEPEYIQLLIDFGANI 241
R E + LL+D AN+
Sbjct: 1221 ETNRNTALTLACFQGRAEVVSLLLDRKANV 1250
Score = 58.2 bits (139), Expect = 9e-09
Identities = 52/190 (27%), Positives = 81/190 (42%), Gaps = 24/190 (12%)
Query: 12 LLQPDKEEEDTDTEEKQALNQAVYDNDSYTLDQLLRQERYKRFINSRSGWGVPG----TP 67
LL+ ++E E AL +A D E + ++S + +P +P
Sbjct: 391 LLEAGADQEHKTDEMHTALMEACMDG---------HVEVARLLLDSGAQVNMPADSFESP 441
Query: 68 LRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSI 127
L LAA GH+ +L+ GA+++ ++ + TPL A GH + V +LL GA+
Sbjct: 442 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 501
Query: 128 YNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDC 187
LT A G E+ D +A +L CS PL A+ GHL+
Sbjct: 502 EETQETALTLACCGG---FSEVADFLIKAGADIEL--------GCSTPLMEASQEGHLEL 550
Query: 188 FRLLLLHGAD 197
+ LL GA+
Sbjct: 551 VKYLLASGAN 560
Score = 48.5 bits (114), Expect = 7e-06
Identities = 30/88 (34%), Positives = 47/88 (53%), Gaps = 1/88 (1%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQ-TPLFTAVSHGHLDCVRVLLEAGASPG 124
TPL AA GHL +Q L++ GA+V+ T + A + GHL V +LL GA P
Sbjct: 603 TPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPT 662
Query: 125 GSIYNNCSPVLTAARDGAVAILQELLDH 152
+ + + ++ AA+ G ++ LLD+
Sbjct: 663 HRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
Score = 47.0 bits (110), Expect = 2e-05
Identities = 23/53 (43%), Positives = 35/53 (66%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLE 118
TPL LA++ GH +Q+L+ GADVD+ D + TPL +A GH+ V+ L++
Sbjct: 1327 TPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
>gi|72534772 ankyrin repeat and SOCS box-containing 9 isoform 1
[Homo sapiens]
Length = 294
Score = 86.3 bits (212), Expect = 3e-17
Identities = 78/248 (31%), Positives = 108/248 (43%), Gaps = 31/248 (12%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGAS--P 123
+PL A GHLSC+++LL HGA V+ + TPLF A G DCV +LL+ GAS P
Sbjct: 71 SPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQP 130
Query: 124 GGSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYG 183
+ SP+ AAR G V + L+ +G + K I+ PLYLA
Sbjct: 131 ESDL---ASPIHEAARRGHVECVNSLIAYGGNIDHK---------ISHLGTPLYLACENQ 178
Query: 184 HLDCFRLLLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNCEPEYIQLLIDFGANIYL 243
C + LL GAD + L V R E LL+DFGA+
Sbjct: 179 QRACVKKLLESGADVNQGKGQDSPLHAVAR-----------TASEELACLLMDFGADTQA 227
Query: 244 PSLS----LDLTSQDDKGIALLLQARATPRSLLSQVRLVVRRALCQAGQPQAINQLDIPP 299
+ ++L + +A L R P SL+ RL +R+ Q I +L +P
Sbjct: 228 KNAEGKRPVELVPPESP-LAQLFLEREGPPSLMQLCRLRIRKCF-GIQQHHKITKLVLPE 285
Query: 300 MLISYLKH 307
L +L H
Sbjct: 286 DLKQFLLH 293
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 85.5 bits (210), Expect = 5e-17
Identities = 65/190 (34%), Positives = 99/190 (52%), Gaps = 20/190 (10%)
Query: 62 GVPG--TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEA 119
G+ G TPL AA+ GH+ +++LLAH ADV++ T L A + G++D V+VLLE+
Sbjct: 297 GIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLES 356
Query: 120 GASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLA 179
GAS N +P++ A G V + + LL++GA N + L LA
Sbjct: 357 GASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSN--------EFKESALTLA 408
Query: 180 AVYGHLDCFRLLLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNCEPEYIQLLIDFGA 239
GHL+ R LL GAD ++ TD+ A L+E C+ + E +LL+D GA
Sbjct: 409 CYKGHLEMVRFLLEAGADQEHK-TDEMHTA-------LMEACMDGHV--EVARLLLDSGA 458
Query: 240 NIYLPSLSLD 249
+ +P+ S +
Sbjct: 459 QVNMPADSFE 468
Score = 77.0 bits (188), Expect = 2e-14
Identities = 54/139 (38%), Positives = 68/139 (48%), Gaps = 8/139 (5%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL AA GHL ++ LLA GA+V + T L A +GH D VLL+AGA
Sbjct: 566 TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 625
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+P++ AAR G V +Q L+ GA N A+N + L LA GHL
Sbjct: 626 ESEGGRTPLMKAARAGHVCTVQFLISKGANVN-----RTTANNDHTV---LSLACAGGHL 677
Query: 186 DCFRLLLLHGADPDYNCTD 204
LLL HGADP + D
Sbjct: 678 AVVELLLAHGADPTHRLKD 696
Score = 73.2 bits (178), Expect = 3e-13
Identities = 57/177 (32%), Positives = 89/177 (50%), Gaps = 17/177 (9%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQ-TPLFTAVSHGHLDCVRVLLEAGASPG 124
TPL LAA+ GH+ +++LL +GAD+++ + + TPL A S G + V +LL GA+
Sbjct: 1118 TPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKE 1177
Query: 125 GSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGH 184
++ +P+ AA G V I++ LL+ GAE N + + S PL LAA+ GH
Sbjct: 1178 HRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGIS-------PLMLAAMNGH 1230
Query: 185 LDCFRLLLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNCEPEYIQLLIDFGANI 241
+LLL G+D + A++ R E + LL+D AN+
Sbjct: 1231 TAAVKLLLDMGSD---------INAQIETNRNTALTLACFQGRTEVVSLLLDRKANV 1278
Score = 69.3 bits (168), Expect = 4e-12
Identities = 58/177 (32%), Positives = 84/177 (47%), Gaps = 20/177 (11%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVK-AQTPLFTAVSHGHLDCVRVLLEAGASPG 124
TPL A S GH+ ++LL +GA +++ + ++ L A GHL+ VR LLEAGA
Sbjct: 369 TPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQE 428
Query: 125 GSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGH 184
+ ++ A DG V + + LLD GA+ N+ A S PL LAA GH
Sbjct: 429 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD---------SFESPLTLAACGGH 479
Query: 185 LDCFRLLLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNCEPEYIQLLIDFGANI 241
++ LL+ GA + D+G + R E E + LL+ GANI
Sbjct: 480 VELAALLIERGASLE-EVNDEGYTPLMEAAREGHE---------EMVALLLGQGANI 526
Score = 64.7 bits (156), Expect = 1e-10
Identities = 55/175 (31%), Positives = 83/175 (47%), Gaps = 33/175 (18%)
Query: 55 INSRSGWGVPGTPLRLAASYGHLSCLQVLLAHGADVDS-LDVKAQTPLFTAVSHGHLDCV 113
INSR+G + +PL LAA GH + +++LL G+D+++ ++ T L A G + V
Sbjct: 1209 INSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVV 1268
Query: 114 RVLLEAGASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWAS-----N 168
+LL+ A+ +P++ AA G + + LLD GA+ N PV +S
Sbjct: 1269 SLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP---PVPSSRDTALT 1325
Query: 169 IASCSG------------------------PLYLAAVYGHLDCFRLLLLHGADPD 199
IA+ G PL+LAA GHLD +LL+ GAD D
Sbjct: 1326 IAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVD 1380
Score = 60.5 bits (145), Expect = 2e-09
Identities = 30/85 (35%), Positives = 50/85 (58%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
T L +AA GH ++L+ GA +D + K TPL+ A + GHLD V++L++AGA
Sbjct: 1322 TALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDA 1381
Query: 126 SIYNNCSPVLTAARDGAVAILQELL 150
+ +P++ A R G V +++ L+
Sbjct: 1382 ADNRKITPLMAAFRKGHVKVVRYLV 1406
Score = 58.2 bits (139), Expect = 9e-09
Identities = 52/191 (27%), Positives = 81/191 (42%), Gaps = 26/191 (13%)
Query: 12 LLQPDKEEEDTDTEEKQALNQAVYDNDSYTLDQLLRQERYKRFINSRSGWGVPG----TP 67
LL+ ++E E AL +A D E + ++S + +P +P
Sbjct: 420 LLEAGADQEHKTDEMHTALMEACMDG---------HVEVARLLLDSGAQVNMPADSFESP 470
Query: 68 LRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSI 127
L LAA GH+ +L+ GA ++ ++ + TPL A GH + V +LL GA+
Sbjct: 471 LTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQT 530
Query: 128 YNNCSPVLT-AARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLD 186
LT A G + + L+ GA+ + CS PL AA GHL+
Sbjct: 531 EETQETALTLACCGGFLEVADFLIKAGADIEL------------GCSTPLMEAAQEGHLE 578
Query: 187 CFRLLLLHGAD 197
+ LL GA+
Sbjct: 579 LVKYLLAAGAN 589
Score = 50.8 bits (120), Expect = 1e-06
Identities = 26/53 (49%), Positives = 35/53 (66%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLE 118
TPL LAA+ GHL +Q+L+ GADVD+ D + TPL A GH+ VR L++
Sbjct: 1355 TPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407
Score = 48.5 bits (114), Expect = 7e-06
Identities = 30/88 (34%), Positives = 48/88 (54%), Gaps = 1/88 (1%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQ-TPLFTAVSHGHLDCVRVLLEAGASPG 124
TPL AA GH+ +Q L++ GA+V+ T L A + GHL V +LL GA P
Sbjct: 632 TPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPT 691
Query: 125 GSIYNNCSPVLTAARDGAVAILQELLDH 152
+ + + ++ AA+ G +++ LLD+
Sbjct: 692 HRLKDGSTMLIEAAKGGHTSVVCYLLDY 719
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 85.5 bits (210), Expect = 5e-17
Identities = 65/190 (34%), Positives = 99/190 (52%), Gaps = 20/190 (10%)
Query: 62 GVPG--TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEA 119
G+ G TPL AA+ GH+ +++LLAH ADV++ T L A + G++D V+VLLE+
Sbjct: 297 GIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLES 356
Query: 120 GASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLA 179
GAS N +P++ A G V + + LL++GA N + L LA
Sbjct: 357 GASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSN--------EFKESALTLA 408
Query: 180 AVYGHLDCFRLLLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNCEPEYIQLLIDFGA 239
GHL+ R LL GAD ++ TD+ A L+E C+ + E +LL+D GA
Sbjct: 409 CYKGHLEMVRFLLEAGADQEHK-TDEMHTA-------LMEACMDGHV--EVARLLLDSGA 458
Query: 240 NIYLPSLSLD 249
+ +P+ S +
Sbjct: 459 QVNMPADSFE 468
Score = 77.0 bits (188), Expect = 2e-14
Identities = 54/139 (38%), Positives = 68/139 (48%), Gaps = 8/139 (5%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL AA GHL ++ LLA GA+V + T L A +GH D VLL+AGA
Sbjct: 566 TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 625
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+P++ AAR G V +Q L+ GA N A+N + L LA GHL
Sbjct: 626 ESEGGRTPLMKAARAGHVCTVQFLISKGANVN-----RTTANNDHTV---LSLACAGGHL 677
Query: 186 DCFRLLLLHGADPDYNCTD 204
LLL HGADP + D
Sbjct: 678 AVVELLLAHGADPTHRLKD 696
Score = 73.2 bits (178), Expect = 3e-13
Identities = 57/177 (32%), Positives = 89/177 (50%), Gaps = 17/177 (9%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQ-TPLFTAVSHGHLDCVRVLLEAGASPG 124
TPL LAA+ GH+ +++LL +GAD+++ + + TPL A S G + V +LL GA+
Sbjct: 867 TPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKE 926
Query: 125 GSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGH 184
++ +P+ AA G V I++ LL+ GAE N + + S PL LAA+ GH
Sbjct: 927 HRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGIS-------PLMLAAMNGH 979
Query: 185 LDCFRLLLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNCEPEYIQLLIDFGANI 241
+LLL G+D + A++ R E + LL+D AN+
Sbjct: 980 TAAVKLLLDMGSD---------INAQIETNRNTALTLACFQGRTEVVSLLLDRKANV 1027
Score = 69.3 bits (168), Expect = 4e-12
Identities = 58/177 (32%), Positives = 84/177 (47%), Gaps = 20/177 (11%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVK-AQTPLFTAVSHGHLDCVRVLLEAGASPG 124
TPL A S GH+ ++LL +GA +++ + ++ L A GHL+ VR LLEAGA
Sbjct: 369 TPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQE 428
Query: 125 GSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGH 184
+ ++ A DG V + + LLD GA+ N+ A S PL LAA GH
Sbjct: 429 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD---------SFESPLTLAACGGH 479
Query: 185 LDCFRLLLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNCEPEYIQLLIDFGANI 241
++ LL+ GA + D+G + R E E + LL+ GANI
Sbjct: 480 VELAALLIERGASLE-EVNDEGYTPLMEAAREGHE---------EMVALLLGQGANI 526
Score = 64.7 bits (156), Expect = 1e-10
Identities = 55/175 (31%), Positives = 83/175 (47%), Gaps = 33/175 (18%)
Query: 55 INSRSGWGVPGTPLRLAASYGHLSCLQVLLAHGADVDS-LDVKAQTPLFTAVSHGHLDCV 113
INSR+G + +PL LAA GH + +++LL G+D+++ ++ T L A G + V
Sbjct: 958 INSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVV 1017
Query: 114 RVLLEAGASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWAS-----N 168
+LL+ A+ +P++ AA G + + LLD GA+ N PV +S
Sbjct: 1018 SLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP---PVPSSRDTALT 1074
Query: 169 IASCSG------------------------PLYLAAVYGHLDCFRLLLLHGADPD 199
IA+ G PL+LAA GHLD +LL+ GAD D
Sbjct: 1075 IAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVD 1129
Score = 60.5 bits (145), Expect = 2e-09
Identities = 30/85 (35%), Positives = 50/85 (58%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
T L +AA GH ++L+ GA +D + K TPL+ A + GHLD V++L++AGA
Sbjct: 1071 TALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDA 1130
Query: 126 SIYNNCSPVLTAARDGAVAILQELL 150
+ +P++ A R G V +++ L+
Sbjct: 1131 ADNRKITPLMAAFRKGHVKVVRYLV 1155
Score = 58.2 bits (139), Expect = 9e-09
Identities = 52/191 (27%), Positives = 81/191 (42%), Gaps = 26/191 (13%)
Query: 12 LLQPDKEEEDTDTEEKQALNQAVYDNDSYTLDQLLRQERYKRFINSRSGWGVPG----TP 67
LL+ ++E E AL +A D E + ++S + +P +P
Sbjct: 420 LLEAGADQEHKTDEMHTALMEACMDG---------HVEVARLLLDSGAQVNMPADSFESP 470
Query: 68 LRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSI 127
L LAA GH+ +L+ GA ++ ++ + TPL A GH + V +LL GA+
Sbjct: 471 LTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQT 530
Query: 128 YNNCSPVLT-AARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLD 186
LT A G + + L+ GA+ + CS PL AA GHL+
Sbjct: 531 EETQETALTLACCGGFLEVADFLIKAGADIEL------------GCSTPLMEAAQEGHLE 578
Query: 187 CFRLLLLHGAD 197
+ LL GA+
Sbjct: 579 LVKYLLAAGAN 589
Score = 50.8 bits (120), Expect = 1e-06
Identities = 26/53 (49%), Positives = 35/53 (66%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLE 118
TPL LAA+ GHL +Q+L+ GADVD+ D + TPL A GH+ VR L++
Sbjct: 1104 TPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1156
Score = 48.5 bits (114), Expect = 7e-06
Identities = 30/88 (34%), Positives = 48/88 (54%), Gaps = 1/88 (1%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQ-TPLFTAVSHGHLDCVRVLLEAGASPG 124
TPL AA GH+ +Q L++ GA+V+ T L A + GHL V +LL GA P
Sbjct: 632 TPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPT 691
Query: 125 GSIYNNCSPVLTAARDGAVAILQELLDH 152
+ + + ++ AA+ G +++ LLD+
Sbjct: 692 HRLKDGSTMLIEAAKGGHTSVVCYLLDY 719
>gi|22208957 ankyrin repeat and SOCS box-containing protein 13 [Homo
sapiens]
Length = 278
Score = 84.7 bits (208), Expect = 9e-17
Identities = 83/281 (29%), Positives = 122/281 (43%), Gaps = 51/281 (18%)
Query: 60 GWGVPGTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEA 119
G+ V TP+ AA G LQ L+ GA V+ + V + TPL A G CV++LL A
Sbjct: 15 GFWVERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAA 74
Query: 120 GASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAEAN--------------------VK 159
GA + +P+ A G++ ++ LL +GA+ N V+
Sbjct: 75 GAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASPLHEACMSGSSECVR 134
Query: 160 AKLPVWASNIA-SC--SGPLYLAAVYGHLDCFRLLLLHGADPDYNCTDQGLLARVPRPRT 216
+ V A+ A C PL++A HLDC ++LL GA+ +
Sbjct: 135 LLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVN--------------AAK 180
Query: 217 LLEICLHHNCE---PEYIQLLIDFGANIYL-------PSLSLDLTSQDDKGIALLLQARA 266
L E LHH + + I++LI+FG NIY PS D T
Sbjct: 181 LHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPS---DYTWSSSAPAKCFEYYEK 237
Query: 267 TPRSLLSQVRLVVRRALCQAGQPQAINQLDIPPMLISYLKH 307
TP +L R+ +R+A G + I +L+IPP LI YL +
Sbjct: 238 TPLTLSQLCRVNLRKATGVRGL-EKIAKLNIPPRLIDYLSY 277
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 84.3 bits (207), Expect = 1e-16
Identities = 70/211 (33%), Positives = 104/211 (49%), Gaps = 24/211 (11%)
Query: 29 ALNQAVYDNDSYTLDQLLRQERYKRFINSRSGWGVPGTPLRLAASYGHLSCLQVLLAHGA 88
AL+ A ++D+ T LL+ + + S++G+ TPL +AA Y +L+ Q+LL GA
Sbjct: 209 ALHIAARNDDTRTAAVLLQNDPNPDVL-SKTGF----TPLHIAAHYENLNVAQLLLNRGA 263
Query: 89 DVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNCSPVLTAARDGAVAILQE 148
V+ TPL A G++ VR+LL+ GA + +P+ AAR+G V I +
Sbjct: 264 SVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEI 323
Query: 149 LLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDCFRLLLLHGADPDYNCTDQGLL 208
LLDHGA K K + P+++AA HLDC RLLL + A+ D D
Sbjct: 324 LLDHGAPIQAKTK---------NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH--- 371
Query: 209 ARVPRPRTLLEICLHHNCEPEYIQLLIDFGA 239
P + C HH ++L+D GA
Sbjct: 372 ---LTPLHVAAHCGHH----RVAKVLLDKGA 395
Score = 78.2 bits (191), Expect = 9e-15
Identities = 63/192 (32%), Positives = 91/192 (47%), Gaps = 14/192 (7%)
Query: 12 LLQPDKEEEDTDTEEKQALNQAVYDNDSYTLDQLLRQERYKRFINSRSGWGVPGTPLRLA 71
LLQ D E +D + L+ A + LL + NSR+ G TPL +A
Sbjct: 357 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP---NSRALNGF--TPLHIA 411
Query: 72 ASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNC 131
H+ +++LL GA +D++ TPL A GHL V+ LL+ GASP S
Sbjct: 412 CKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE 471
Query: 132 SPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDCFRLL 191
+P+ AAR G + + LL + A+ N KAK PL+ AA GH + +LL
Sbjct: 472 TPLHMAARAGHTEVAKYLLQNKAKVNAKAK---------DDQTPLHCAARIGHTNMVKLL 522
Query: 192 LLHGADPDYNCT 203
L + A+P+ T
Sbjct: 523 LENNANPNLATT 534
Score = 74.7 bits (182), Expect = 1e-13
Identities = 45/127 (35%), Positives = 65/127 (51%), Gaps = 9/127 (7%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL +AA YG + ++LL A ++ TPL AV H +LD V++LL G SP
Sbjct: 571 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 630
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+N +P+ AA+ V + + LL +G AN ++ V PL+LAA GH
Sbjct: 631 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV---------TPLHLAAQEGHA 681
Query: 186 DCFRLLL 192
+ LLL
Sbjct: 682 EMVALLL 688
Score = 72.8 bits (177), Expect = 4e-13
Identities = 42/134 (31%), Positives = 68/134 (50%), Gaps = 9/134 (6%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
+P+ +AA HL C+++LL + A++D + + TPL A GH +VLL+ GA P
Sbjct: 340 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 399
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
N +P+ A + V +++ LL GA + + S PL++A+ GHL
Sbjct: 400 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTE---------SGLTPLHVASFMGHL 450
Query: 186 DCFRLLLLHGADPD 199
+ LL GA P+
Sbjct: 451 PIVKNLLQRGASPN 464
Score = 68.9 bits (167), Expect = 5e-12
Identities = 47/142 (33%), Positives = 69/142 (48%), Gaps = 10/142 (7%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL AA GH+ ++LL HGA + + +P+ A HLDCVR+LL+ A
Sbjct: 307 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 366
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
++ +P+ AA G + + LLD GA+ N +A + PL++A H+
Sbjct: 367 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA---------LNGFTPLHIACKKNHV 417
Query: 186 DCFRLLLLHGADPDYNCTDQGL 207
LLL GA D T+ GL
Sbjct: 418 RVMELLLKTGASID-AVTESGL 438
Score = 68.9 bits (167), Expect = 5e-12
Identities = 49/155 (31%), Positives = 73/155 (47%), Gaps = 11/155 (7%)
Query: 50 RYKRFINSRSGWGVPGTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGH 109
+Y N+ S GV TPL LAA GH + +LL+ A+ + + TPL GH
Sbjct: 656 QYGGSANAESVQGV--TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH 713
Query: 110 LDCVRVLLEAGASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNI 169
+ VL++ G + +P+ A+ G + +++ LL H A+ N K KL
Sbjct: 714 VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY----- 768
Query: 170 ASCSGPLYLAAVYGHLDCFRLLLLHGADPDYNCTD 204
PL+ AA GH D LLL +GA P+ +D
Sbjct: 769 ----SPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 799
Score = 66.6 bits (161), Expect = 3e-11
Identities = 55/180 (30%), Positives = 83/180 (46%), Gaps = 19/180 (10%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL +AA GH + LL + A V++ QTPL A GH + V++LLE A+P
Sbjct: 472 TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 531
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+ +P+ AAR+G V + LL+ A K PL++AA YG +
Sbjct: 532 ATTAGHTPLHIAAREGHVETVLALLEKEASQACMTK---------KGFTPLHVAAKYGKV 582
Query: 186 DCFRLLLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNCEPEYIQLLIDFGANIYLPS 245
LLL A P+ A T L + +HHN + ++LL+ G + + P+
Sbjct: 583 RVAELLLERDAHPN---------AAGKNGLTPLHVAVHHN-NLDIVKLLLPRGGSPHSPA 632
Score = 59.7 bits (143), Expect = 3e-09
Identities = 44/155 (28%), Positives = 78/155 (50%), Gaps = 20/155 (12%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
T L +AA G ++ L+ +GA+V++ K TPL+ A HL+ V+ LLE GA+
Sbjct: 113 TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 172
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVK-AKLPVWASN---------------- 168
+ + +P+ A + G ++ L+++G + V+ L + A N
Sbjct: 173 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNP 232
Query: 169 -IASCSG--PLYLAAVYGHLDCFRLLLLHGADPDY 200
+ S +G PL++AA Y +L+ +LLL GA ++
Sbjct: 233 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 267
Score = 57.4 bits (137), Expect = 2e-08
Identities = 30/84 (35%), Positives = 47/84 (55%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL +A+ YG++ ++ LL H ADV++ +PL A GH D V +LL+ GASP
Sbjct: 736 TPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 795
Query: 126 SIYNNCSPVLTAARDGAVAILQEL 149
+ +P+ A R G +++ L
Sbjct: 796 VSSDGTTPLAIAKRLGYISVTDVL 819
Score = 53.5 bits (127), Expect = 2e-07
Identities = 38/134 (28%), Positives = 58/134 (43%), Gaps = 9/134 (6%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL +A + +L +++LL G S TPL A ++ R LL+ G S
Sbjct: 604 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 663
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+P+ AA++G ++ LL A N+ K S PL+L A GH+
Sbjct: 664 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNK---------SGLTPLHLVAQEGHV 714
Query: 186 DCFRLLLLHGADPD 199
+L+ HG D
Sbjct: 715 PVADVLIKHGVMVD 728
Score = 51.6 bits (122), Expect = 9e-07
Identities = 66/250 (26%), Positives = 104/250 (41%), Gaps = 24/250 (9%)
Query: 13 LQPDKEEEDTDTEEKQALNQAVYDNDSYT----------LDQLLRQERYKRFINSRSGWG 62
LQ KE+E+++ + + D+ T LD+ L R IN+ + G
Sbjct: 19 LQEQKEKEESNRKRRNRSRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNG 78
Query: 63 VPGTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGAS 122
+ G L LA+ GH+ + LL +++ K T L A G + VR L+ GA+
Sbjct: 79 LNG--LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGAN 136
Query: 123 PGGSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAA-- 180
+P+ AA++ + +++ LL++GA NV + +A G + A
Sbjct: 137 VNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 196
Query: 181 -VYGHLDCFRLLLLH-GADPDYNCTDQGLLARVPRPRTL-------LEICLHHNCEPEYI 231
YG RL LH A D T LL P P L L I H+
Sbjct: 197 INYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYE-NLNVA 255
Query: 232 QLLIDFGANI 241
QLL++ GA++
Sbjct: 256 QLLLNRGASV 265
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 84.3 bits (207), Expect = 1e-16
Identities = 70/211 (33%), Positives = 104/211 (49%), Gaps = 24/211 (11%)
Query: 29 ALNQAVYDNDSYTLDQLLRQERYKRFINSRSGWGVPGTPLRLAASYGHLSCLQVLLAHGA 88
AL+ A ++D+ T LL+ + + S++G+ TPL +AA Y +L+ Q+LL GA
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVL-SKTGF----TPLHIAAHYENLNVAQLLLNRGA 230
Query: 89 DVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNCSPVLTAARDGAVAILQE 148
V+ TPL A G++ VR+LL+ GA + +P+ AAR+G V I +
Sbjct: 231 SVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEI 290
Query: 149 LLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDCFRLLLLHGADPDYNCTDQGLL 208
LLDHGA K K + P+++AA HLDC RLLL + A+ D D
Sbjct: 291 LLDHGAPIQAKTK---------NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH--- 338
Query: 209 ARVPRPRTLLEICLHHNCEPEYIQLLIDFGA 239
P + C HH ++L+D GA
Sbjct: 339 ---LTPLHVAAHCGHH----RVAKVLLDKGA 362
Score = 78.2 bits (191), Expect = 9e-15
Identities = 63/192 (32%), Positives = 91/192 (47%), Gaps = 14/192 (7%)
Query: 12 LLQPDKEEEDTDTEEKQALNQAVYDNDSYTLDQLLRQERYKRFINSRSGWGVPGTPLRLA 71
LLQ D E +D + L+ A + LL + NSR+ G TPL +A
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP---NSRALNGF--TPLHIA 378
Query: 72 ASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNC 131
H+ +++LL GA +D++ TPL A GHL V+ LL+ GASP S
Sbjct: 379 CKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE 438
Query: 132 SPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDCFRLL 191
+P+ AAR G + + LL + A+ N KAK PL+ AA GH + +LL
Sbjct: 439 TPLHMAARAGHTEVAKYLLQNKAKVNAKAK---------DDQTPLHCAARIGHTNMVKLL 489
Query: 192 LLHGADPDYNCT 203
L + A+P+ T
Sbjct: 490 LENNANPNLATT 501
Score = 74.7 bits (182), Expect = 1e-13
Identities = 45/127 (35%), Positives = 65/127 (51%), Gaps = 9/127 (7%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL +AA YG + ++LL A ++ TPL AV H +LD V++LL G SP
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+N +P+ AA+ V + + LL +G AN ++ V PL+LAA GH
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV---------TPLHLAAQEGHA 648
Query: 186 DCFRLLL 192
+ LLL
Sbjct: 649 EMVALLL 655
Score = 72.8 bits (177), Expect = 4e-13
Identities = 42/134 (31%), Positives = 68/134 (50%), Gaps = 9/134 (6%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
+P+ +AA HL C+++LL + A++D + + TPL A GH +VLL+ GA P
Sbjct: 307 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
N +P+ A + V +++ LL GA + + S PL++A+ GHL
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTE---------SGLTPLHVASFMGHL 417
Query: 186 DCFRLLLLHGADPD 199
+ LL GA P+
Sbjct: 418 PIVKNLLQRGASPN 431
Score = 68.9 bits (167), Expect = 5e-12
Identities = 47/142 (33%), Positives = 69/142 (48%), Gaps = 10/142 (7%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL AA GH+ ++LL HGA + + +P+ A HLDCVR+LL+ A
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
++ +P+ AA G + + LLD GA+ N +A + PL++A H+
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA---------LNGFTPLHIACKKNHV 384
Query: 186 DCFRLLLLHGADPDYNCTDQGL 207
LLL GA D T+ GL
Sbjct: 385 RVMELLLKTGASID-AVTESGL 405
Score = 68.9 bits (167), Expect = 5e-12
Identities = 49/155 (31%), Positives = 73/155 (47%), Gaps = 11/155 (7%)
Query: 50 RYKRFINSRSGWGVPGTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGH 109
+Y N+ S GV TPL LAA GH + +LL+ A+ + + TPL GH
Sbjct: 623 QYGGSANAESVQGV--TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH 680
Query: 110 LDCVRVLLEAGASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNI 169
+ VL++ G + +P+ A+ G + +++ LL H A+ N K KL
Sbjct: 681 VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY----- 735
Query: 170 ASCSGPLYLAAVYGHLDCFRLLLLHGADPDYNCTD 204
PL+ AA GH D LLL +GA P+ +D
Sbjct: 736 ----SPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 766
Score = 66.6 bits (161), Expect = 3e-11
Identities = 55/180 (30%), Positives = 83/180 (46%), Gaps = 19/180 (10%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL +AA GH + LL + A V++ QTPL A GH + V++LLE A+P
Sbjct: 439 TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 498
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+ +P+ AAR+G V + LL+ A K PL++AA YG +
Sbjct: 499 ATTAGHTPLHIAAREGHVETVLALLEKEASQACMTK---------KGFTPLHVAAKYGKV 549
Query: 186 DCFRLLLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNCEPEYIQLLIDFGANIYLPS 245
LLL A P+ A T L + +HHN + ++LL+ G + + P+
Sbjct: 550 RVAELLLERDAHPN---------AAGKNGLTPLHVAVHHN-NLDIVKLLLPRGGSPHSPA 599
Score = 59.7 bits (143), Expect = 3e-09
Identities = 44/155 (28%), Positives = 78/155 (50%), Gaps = 20/155 (12%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
T L +AA G ++ L+ +GA+V++ K TPL+ A HL+ V+ LLE GA+
Sbjct: 80 TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVK-AKLPVWASN---------------- 168
+ + +P+ A + G ++ L+++G + V+ L + A N
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNP 199
Query: 169 -IASCSG--PLYLAAVYGHLDCFRLLLLHGADPDY 200
+ S +G PL++AA Y +L+ +LLL GA ++
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 234
Score = 57.4 bits (137), Expect = 2e-08
Identities = 30/84 (35%), Positives = 47/84 (55%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL +A+ YG++ ++ LL H ADV++ +PL A GH D V +LL+ GASP
Sbjct: 703 TPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 762
Query: 126 SIYNNCSPVLTAARDGAVAILQEL 149
+ +P+ A R G +++ L
Sbjct: 763 VSSDGTTPLAIAKRLGYISVTDVL 786
Score = 53.5 bits (127), Expect = 2e-07
Identities = 38/134 (28%), Positives = 58/134 (43%), Gaps = 9/134 (6%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL +A + +L +++LL G S TPL A ++ R LL+ G S
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+P+ AA++G ++ LL A N+ K S PL+L A GH+
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNK---------SGLTPLHLVAQEGHV 681
Query: 186 DCFRLLLLHGADPD 199
+L+ HG D
Sbjct: 682 PVADVLIKHGVMVD 695
Score = 49.7 bits (117), Expect = 3e-06
Identities = 51/200 (25%), Positives = 87/200 (43%), Gaps = 21/200 (10%)
Query: 71 AASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNN 130
AA G+L L +G D+++ + L A GH+ V LL +
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 131 CSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDCFRL 190
+ + AA G +++EL+++GA N +++ PLY+AA HL+ +
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQ---------KGFTPLYMAAQENHLEVVKF 129
Query: 191 LLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNCEPEYIQLLIDFG--ANIYLPSLSL 248
LL +GA+ + T+ G T L + L E + LI++G + LP+L +
Sbjct: 130 LLENGANQNV-ATEDGF--------TPLAVALQQGHE-NVVAHLINYGTKGKVRLPALHI 179
Query: 249 DLTSQDDKGIALLLQARATP 268
+ D + A+LLQ P
Sbjct: 180 AARNDDTRTAAVLLQNDPNP 199
Score = 48.9 bits (115), Expect = 6e-06
Identities = 60/214 (28%), Positives = 91/214 (42%), Gaps = 14/214 (6%)
Query: 39 SYTLDQLLRQERYKRFINSRSGWGVPGTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQ 98
S LD+ L R IN+ + G+ G L LA+ GH+ + LL +++ K
Sbjct: 22 SGNLDKALDHLRNGVDINTCNQNGLNG--LHLASKEGHVKMVVELLHKEIILETTTKKGN 79
Query: 99 TPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAEANV 158
T L A G + VR L+ GA+ +P+ AA++ + +++ LL++GA NV
Sbjct: 80 TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139
Query: 159 KAKLPVWASNIASCSGPLYLAA---VYGHLDCFRLLLLH-GADPDYNCTDQGLLARVPRP 214
+ +A G + A YG RL LH A D T LL P P
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNP 199
Query: 215 RTL-------LEICLHHNCEPEYIQLLIDFGANI 241
L L I H+ QLL++ GA++
Sbjct: 200 DVLSKTGFTPLHIAAHYE-NLNVAQLLLNRGASV 232
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 84.3 bits (207), Expect = 1e-16
Identities = 70/211 (33%), Positives = 104/211 (49%), Gaps = 24/211 (11%)
Query: 29 ALNQAVYDNDSYTLDQLLRQERYKRFINSRSGWGVPGTPLRLAASYGHLSCLQVLLAHGA 88
AL+ A ++D+ T LL+ + + S++G+ TPL +AA Y +L+ Q+LL GA
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVL-SKTGF----TPLHIAAHYENLNVAQLLLNRGA 230
Query: 89 DVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNCSPVLTAARDGAVAILQE 148
V+ TPL A G++ VR+LL+ GA + +P+ AAR+G V I +
Sbjct: 231 SVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEI 290
Query: 149 LLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDCFRLLLLHGADPDYNCTDQGLL 208
LLDHGA K K + P+++AA HLDC RLLL + A+ D D
Sbjct: 291 LLDHGAPIQAKTK---------NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH--- 338
Query: 209 ARVPRPRTLLEICLHHNCEPEYIQLLIDFGA 239
P + C HH ++L+D GA
Sbjct: 339 ---LTPLHVAAHCGHH----RVAKVLLDKGA 362
Score = 78.2 bits (191), Expect = 9e-15
Identities = 63/192 (32%), Positives = 91/192 (47%), Gaps = 14/192 (7%)
Query: 12 LLQPDKEEEDTDTEEKQALNQAVYDNDSYTLDQLLRQERYKRFINSRSGWGVPGTPLRLA 71
LLQ D E +D + L+ A + LL + NSR+ G TPL +A
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP---NSRALNGF--TPLHIA 378
Query: 72 ASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNC 131
H+ +++LL GA +D++ TPL A GHL V+ LL+ GASP S
Sbjct: 379 CKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE 438
Query: 132 SPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDCFRLL 191
+P+ AAR G + + LL + A+ N KAK PL+ AA GH + +LL
Sbjct: 439 TPLHMAARAGHTEVAKYLLQNKAKVNAKAK---------DDQTPLHCAARIGHTNMVKLL 489
Query: 192 LLHGADPDYNCT 203
L + A+P+ T
Sbjct: 490 LENNANPNLATT 501
Score = 74.7 bits (182), Expect = 1e-13
Identities = 45/127 (35%), Positives = 65/127 (51%), Gaps = 9/127 (7%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL +AA YG + ++LL A ++ TPL AV H +LD V++LL G SP
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+N +P+ AA+ V + + LL +G AN ++ V PL+LAA GH
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV---------TPLHLAAQEGHA 648
Query: 186 DCFRLLL 192
+ LLL
Sbjct: 649 EMVALLL 655
Score = 72.8 bits (177), Expect = 4e-13
Identities = 42/134 (31%), Positives = 68/134 (50%), Gaps = 9/134 (6%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
+P+ +AA HL C+++LL + A++D + + TPL A GH +VLL+ GA P
Sbjct: 307 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
N +P+ A + V +++ LL GA + + S PL++A+ GHL
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTE---------SGLTPLHVASFMGHL 417
Query: 186 DCFRLLLLHGADPD 199
+ LL GA P+
Sbjct: 418 PIVKNLLQRGASPN 431
Score = 68.9 bits (167), Expect = 5e-12
Identities = 47/142 (33%), Positives = 69/142 (48%), Gaps = 10/142 (7%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL AA GH+ ++LL HGA + + +P+ A HLDCVR+LL+ A
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
++ +P+ AA G + + LLD GA+ N +A + PL++A H+
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA---------LNGFTPLHIACKKNHV 384
Query: 186 DCFRLLLLHGADPDYNCTDQGL 207
LLL GA D T+ GL
Sbjct: 385 RVMELLLKTGASID-AVTESGL 405
Score = 68.9 bits (167), Expect = 5e-12
Identities = 49/155 (31%), Positives = 73/155 (47%), Gaps = 11/155 (7%)
Query: 50 RYKRFINSRSGWGVPGTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGH 109
+Y N+ S GV TPL LAA GH + +LL+ A+ + + TPL GH
Sbjct: 623 QYGGSANAESVQGV--TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH 680
Query: 110 LDCVRVLLEAGASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNI 169
+ VL++ G + +P+ A+ G + +++ LL H A+ N K KL
Sbjct: 681 VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY----- 735
Query: 170 ASCSGPLYLAAVYGHLDCFRLLLLHGADPDYNCTD 204
PL+ AA GH D LLL +GA P+ +D
Sbjct: 736 ----SPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 766
Score = 66.6 bits (161), Expect = 3e-11
Identities = 55/180 (30%), Positives = 83/180 (46%), Gaps = 19/180 (10%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL +AA GH + LL + A V++ QTPL A GH + V++LLE A+P
Sbjct: 439 TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 498
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+ +P+ AAR+G V + LL+ A K PL++AA YG +
Sbjct: 499 ATTAGHTPLHIAAREGHVETVLALLEKEASQACMTK---------KGFTPLHVAAKYGKV 549
Query: 186 DCFRLLLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNCEPEYIQLLIDFGANIYLPS 245
LLL A P+ A T L + +HHN + ++LL+ G + + P+
Sbjct: 550 RVAELLLERDAHPN---------AAGKNGLTPLHVAVHHN-NLDIVKLLLPRGGSPHSPA 599
Score = 59.7 bits (143), Expect = 3e-09
Identities = 44/155 (28%), Positives = 78/155 (50%), Gaps = 20/155 (12%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
T L +AA G ++ L+ +GA+V++ K TPL+ A HL+ V+ LLE GA+
Sbjct: 80 TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVK-AKLPVWASN---------------- 168
+ + +P+ A + G ++ L+++G + V+ L + A N
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNP 199
Query: 169 -IASCSG--PLYLAAVYGHLDCFRLLLLHGADPDY 200
+ S +G PL++AA Y +L+ +LLL GA ++
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 234
Score = 57.4 bits (137), Expect = 2e-08
Identities = 30/84 (35%), Positives = 47/84 (55%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL +A+ YG++ ++ LL H ADV++ +PL A GH D V +LL+ GASP
Sbjct: 703 TPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 762
Query: 126 SIYNNCSPVLTAARDGAVAILQEL 149
+ +P+ A R G +++ L
Sbjct: 763 VSSDGTTPLAIAKRLGYISVTDVL 786
Score = 53.5 bits (127), Expect = 2e-07
Identities = 38/134 (28%), Positives = 58/134 (43%), Gaps = 9/134 (6%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL +A + +L +++LL G S TPL A ++ R LL+ G S
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+P+ AA++G ++ LL A N+ K S PL+L A GH+
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNK---------SGLTPLHLVAQEGHV 681
Query: 186 DCFRLLLLHGADPD 199
+L+ HG D
Sbjct: 682 PVADVLIKHGVMVD 695
Score = 49.7 bits (117), Expect = 3e-06
Identities = 51/200 (25%), Positives = 87/200 (43%), Gaps = 21/200 (10%)
Query: 71 AASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNN 130
AA G+L L +G D+++ + L A GH+ V LL +
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 131 CSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDCFRL 190
+ + AA G +++EL+++GA N +++ PLY+AA HL+ +
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQ---------KGFTPLYMAAQENHLEVVKF 129
Query: 191 LLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNCEPEYIQLLIDFG--ANIYLPSLSL 248
LL +GA+ + T+ G T L + L E + LI++G + LP+L +
Sbjct: 130 LLENGANQNV-ATEDGF--------TPLAVALQQGHE-NVVAHLINYGTKGKVRLPALHI 179
Query: 249 DLTSQDDKGIALLLQARATP 268
+ D + A+LLQ P
Sbjct: 180 AARNDDTRTAAVLLQNDPNP 199
Score = 48.9 bits (115), Expect = 6e-06
Identities = 60/214 (28%), Positives = 91/214 (42%), Gaps = 14/214 (6%)
Query: 39 SYTLDQLLRQERYKRFINSRSGWGVPGTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQ 98
S LD+ L R IN+ + G+ G L LA+ GH+ + LL +++ K
Sbjct: 22 SGNLDKALDHLRNGVDINTCNQNGLNG--LHLASKEGHVKMVVELLHKEIILETTTKKGN 79
Query: 99 TPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAEANV 158
T L A G + VR L+ GA+ +P+ AA++ + +++ LL++GA NV
Sbjct: 80 TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139
Query: 159 KAKLPVWASNIASCSGPLYLAA---VYGHLDCFRLLLLH-GADPDYNCTDQGLLARVPRP 214
+ +A G + A YG RL LH A D T LL P P
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNP 199
Query: 215 RTL-------LEICLHHNCEPEYIQLLIDFGANI 241
L L I H+ QLL++ GA++
Sbjct: 200 DVLSKTGFTPLHIAAHYE-NLNVAQLLLNRGASV 232
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 84.3 bits (207), Expect = 1e-16
Identities = 70/211 (33%), Positives = 104/211 (49%), Gaps = 24/211 (11%)
Query: 29 ALNQAVYDNDSYTLDQLLRQERYKRFINSRSGWGVPGTPLRLAASYGHLSCLQVLLAHGA 88
AL+ A ++D+ T LL+ + + S++G+ TPL +AA Y +L+ Q+LL GA
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVL-SKTGF----TPLHIAAHYENLNVAQLLLNRGA 230
Query: 89 DVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNCSPVLTAARDGAVAILQE 148
V+ TPL A G++ VR+LL+ GA + +P+ AAR+G V I +
Sbjct: 231 SVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEI 290
Query: 149 LLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDCFRLLLLHGADPDYNCTDQGLL 208
LLDHGA K K + P+++AA HLDC RLLL + A+ D D
Sbjct: 291 LLDHGAPIQAKTK---------NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH--- 338
Query: 209 ARVPRPRTLLEICLHHNCEPEYIQLLIDFGA 239
P + C HH ++L+D GA
Sbjct: 339 ---LTPLHVAAHCGHH----RVAKVLLDKGA 362
Score = 78.2 bits (191), Expect = 9e-15
Identities = 63/192 (32%), Positives = 91/192 (47%), Gaps = 14/192 (7%)
Query: 12 LLQPDKEEEDTDTEEKQALNQAVYDNDSYTLDQLLRQERYKRFINSRSGWGVPGTPLRLA 71
LLQ D E +D + L+ A + LL + NSR+ G TPL +A
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP---NSRALNGF--TPLHIA 378
Query: 72 ASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNC 131
H+ +++LL GA +D++ TPL A GHL V+ LL+ GASP S
Sbjct: 379 CKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE 438
Query: 132 SPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDCFRLL 191
+P+ AAR G + + LL + A+ N KAK PL+ AA GH + +LL
Sbjct: 439 TPLHMAARAGHTEVAKYLLQNKAKVNAKAK---------DDQTPLHCAARIGHTNMVKLL 489
Query: 192 LLHGADPDYNCT 203
L + A+P+ T
Sbjct: 490 LENNANPNLATT 501
Score = 74.7 bits (182), Expect = 1e-13
Identities = 45/127 (35%), Positives = 65/127 (51%), Gaps = 9/127 (7%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL +AA YG + ++LL A ++ TPL AV H +LD V++LL G SP
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+N +P+ AA+ V + + LL +G AN ++ V PL+LAA GH
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV---------TPLHLAAQEGHA 648
Query: 186 DCFRLLL 192
+ LLL
Sbjct: 649 EMVALLL 655
Score = 72.8 bits (177), Expect = 4e-13
Identities = 42/134 (31%), Positives = 68/134 (50%), Gaps = 9/134 (6%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
+P+ +AA HL C+++LL + A++D + + TPL A GH +VLL+ GA P
Sbjct: 307 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
N +P+ A + V +++ LL GA + + S PL++A+ GHL
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTE---------SGLTPLHVASFMGHL 417
Query: 186 DCFRLLLLHGADPD 199
+ LL GA P+
Sbjct: 418 PIVKNLLQRGASPN 431
Score = 68.9 bits (167), Expect = 5e-12
Identities = 47/142 (33%), Positives = 69/142 (48%), Gaps = 10/142 (7%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL AA GH+ ++LL HGA + + +P+ A HLDCVR+LL+ A
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
++ +P+ AA G + + LLD GA+ N +A + PL++A H+
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA---------LNGFTPLHIACKKNHV 384
Query: 186 DCFRLLLLHGADPDYNCTDQGL 207
LLL GA D T+ GL
Sbjct: 385 RVMELLLKTGASID-AVTESGL 405
Score = 68.9 bits (167), Expect = 5e-12
Identities = 49/155 (31%), Positives = 73/155 (47%), Gaps = 11/155 (7%)
Query: 50 RYKRFINSRSGWGVPGTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGH 109
+Y N+ S GV TPL LAA GH + +LL+ A+ + + TPL GH
Sbjct: 623 QYGGSANAESVQGV--TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH 680
Query: 110 LDCVRVLLEAGASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNI 169
+ VL++ G + +P+ A+ G + +++ LL H A+ N K KL
Sbjct: 681 VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY----- 735
Query: 170 ASCSGPLYLAAVYGHLDCFRLLLLHGADPDYNCTD 204
PL+ AA GH D LLL +GA P+ +D
Sbjct: 736 ----SPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 766
Score = 66.6 bits (161), Expect = 3e-11
Identities = 55/180 (30%), Positives = 83/180 (46%), Gaps = 19/180 (10%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL +AA GH + LL + A V++ QTPL A GH + V++LLE A+P
Sbjct: 439 TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 498
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+ +P+ AAR+G V + LL+ A K PL++AA YG +
Sbjct: 499 ATTAGHTPLHIAAREGHVETVLALLEKEASQACMTK---------KGFTPLHVAAKYGKV 549
Query: 186 DCFRLLLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNCEPEYIQLLIDFGANIYLPS 245
LLL A P+ A T L + +HHN + ++LL+ G + + P+
Sbjct: 550 RVAELLLERDAHPN---------AAGKNGLTPLHVAVHHN-NLDIVKLLLPRGGSPHSPA 599
Score = 59.7 bits (143), Expect = 3e-09
Identities = 44/155 (28%), Positives = 78/155 (50%), Gaps = 20/155 (12%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
T L +AA G ++ L+ +GA+V++ K TPL+ A HL+ V+ LLE GA+
Sbjct: 80 TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVK-AKLPVWASN---------------- 168
+ + +P+ A + G ++ L+++G + V+ L + A N
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNP 199
Query: 169 -IASCSG--PLYLAAVYGHLDCFRLLLLHGADPDY 200
+ S +G PL++AA Y +L+ +LLL GA ++
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 234
Score = 57.4 bits (137), Expect = 2e-08
Identities = 30/84 (35%), Positives = 47/84 (55%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL +A+ YG++ ++ LL H ADV++ +PL A GH D V +LL+ GASP
Sbjct: 703 TPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 762
Query: 126 SIYNNCSPVLTAARDGAVAILQEL 149
+ +P+ A R G +++ L
Sbjct: 763 VSSDGTTPLAIAKRLGYISVTDVL 786
Score = 53.5 bits (127), Expect = 2e-07
Identities = 38/134 (28%), Positives = 58/134 (43%), Gaps = 9/134 (6%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL +A + +L +++LL G S TPL A ++ R LL+ G S
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+P+ AA++G ++ LL A N+ K S PL+L A GH+
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNK---------SGLTPLHLVAQEGHV 681
Query: 186 DCFRLLLLHGADPD 199
+L+ HG D
Sbjct: 682 PVADVLIKHGVMVD 695
Score = 49.7 bits (117), Expect = 3e-06
Identities = 51/200 (25%), Positives = 87/200 (43%), Gaps = 21/200 (10%)
Query: 71 AASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNN 130
AA G+L L +G D+++ + L A GH+ V LL +
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 131 CSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDCFRL 190
+ + AA G +++EL+++GA N +++ PLY+AA HL+ +
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQ---------KGFTPLYMAAQENHLEVVKF 129
Query: 191 LLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNCEPEYIQLLIDFG--ANIYLPSLSL 248
LL +GA+ + T+ G T L + L E + LI++G + LP+L +
Sbjct: 130 LLENGANQNV-ATEDGF--------TPLAVALQQGHE-NVVAHLINYGTKGKVRLPALHI 179
Query: 249 DLTSQDDKGIALLLQARATP 268
+ D + A+LLQ P
Sbjct: 180 AARNDDTRTAAVLLQNDPNP 199
Score = 48.9 bits (115), Expect = 6e-06
Identities = 60/214 (28%), Positives = 91/214 (42%), Gaps = 14/214 (6%)
Query: 39 SYTLDQLLRQERYKRFINSRSGWGVPGTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQ 98
S LD+ L R IN+ + G+ G L LA+ GH+ + LL +++ K
Sbjct: 22 SGNLDKALDHLRNGVDINTCNQNGLNG--LHLASKEGHVKMVVELLHKEIILETTTKKGN 79
Query: 99 TPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAEANV 158
T L A G + VR L+ GA+ +P+ AA++ + +++ LL++GA NV
Sbjct: 80 TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139
Query: 159 KAKLPVWASNIASCSGPLYLAA---VYGHLDCFRLLLLH-GADPDYNCTDQGLLARVPRP 214
+ +A G + A YG RL LH A D T LL P P
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNP 199
Query: 215 RTL-------LEICLHHNCEPEYIQLLIDFGANI 241
L L I H+ QLL++ GA++
Sbjct: 200 DVLSKTGFTPLHIAAHYE-NLNVAQLLLNRGASV 232
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 84.3 bits (207), Expect = 1e-16
Identities = 70/211 (33%), Positives = 104/211 (49%), Gaps = 24/211 (11%)
Query: 29 ALNQAVYDNDSYTLDQLLRQERYKRFINSRSGWGVPGTPLRLAASYGHLSCLQVLLAHGA 88
AL+ A ++D+ T LL+ + + S++G+ TPL +AA Y +L+ Q+LL GA
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVL-SKTGF----TPLHIAAHYENLNVAQLLLNRGA 230
Query: 89 DVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNCSPVLTAARDGAVAILQE 148
V+ TPL A G++ VR+LL+ GA + +P+ AAR+G V I +
Sbjct: 231 SVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEI 290
Query: 149 LLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDCFRLLLLHGADPDYNCTDQGLL 208
LLDHGA K K + P+++AA HLDC RLLL + A+ D D
Sbjct: 291 LLDHGAPIQAKTK---------NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH--- 338
Query: 209 ARVPRPRTLLEICLHHNCEPEYIQLLIDFGA 239
P + C HH ++L+D GA
Sbjct: 339 ---LTPLHVAAHCGHH----RVAKVLLDKGA 362
Score = 78.2 bits (191), Expect = 9e-15
Identities = 63/192 (32%), Positives = 91/192 (47%), Gaps = 14/192 (7%)
Query: 12 LLQPDKEEEDTDTEEKQALNQAVYDNDSYTLDQLLRQERYKRFINSRSGWGVPGTPLRLA 71
LLQ D E +D + L+ A + LL + NSR+ G TPL +A
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP---NSRALNGF--TPLHIA 378
Query: 72 ASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNC 131
H+ +++LL GA +D++ TPL A GHL V+ LL+ GASP S
Sbjct: 379 CKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE 438
Query: 132 SPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDCFRLL 191
+P+ AAR G + + LL + A+ N KAK PL+ AA GH + +LL
Sbjct: 439 TPLHMAARAGHTEVAKYLLQNKAKVNAKAK---------DDQTPLHCAARIGHTNMVKLL 489
Query: 192 LLHGADPDYNCT 203
L + A+P+ T
Sbjct: 490 LENNANPNLATT 501
Score = 74.7 bits (182), Expect = 1e-13
Identities = 45/127 (35%), Positives = 65/127 (51%), Gaps = 9/127 (7%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL +AA YG + ++LL A ++ TPL AV H +LD V++LL G SP
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+N +P+ AA+ V + + LL +G AN ++ V PL+LAA GH
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV---------TPLHLAAQEGHA 648
Query: 186 DCFRLLL 192
+ LLL
Sbjct: 649 EMVALLL 655
Score = 72.8 bits (177), Expect = 4e-13
Identities = 42/134 (31%), Positives = 68/134 (50%), Gaps = 9/134 (6%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
+P+ +AA HL C+++LL + A++D + + TPL A GH +VLL+ GA P
Sbjct: 307 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
N +P+ A + V +++ LL GA + + S PL++A+ GHL
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTE---------SGLTPLHVASFMGHL 417
Query: 186 DCFRLLLLHGADPD 199
+ LL GA P+
Sbjct: 418 PIVKNLLQRGASPN 431
Score = 68.9 bits (167), Expect = 5e-12
Identities = 47/142 (33%), Positives = 69/142 (48%), Gaps = 10/142 (7%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL AA GH+ ++LL HGA + + +P+ A HLDCVR+LL+ A
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
++ +P+ AA G + + LLD GA+ N +A + PL++A H+
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA---------LNGFTPLHIACKKNHV 384
Query: 186 DCFRLLLLHGADPDYNCTDQGL 207
LLL GA D T+ GL
Sbjct: 385 RVMELLLKTGASID-AVTESGL 405
Score = 68.9 bits (167), Expect = 5e-12
Identities = 49/155 (31%), Positives = 73/155 (47%), Gaps = 11/155 (7%)
Query: 50 RYKRFINSRSGWGVPGTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGH 109
+Y N+ S GV TPL LAA GH + +LL+ A+ + + TPL GH
Sbjct: 623 QYGGSANAESVQGV--TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH 680
Query: 110 LDCVRVLLEAGASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNI 169
+ VL++ G + +P+ A+ G + +++ LL H A+ N K KL
Sbjct: 681 VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY----- 735
Query: 170 ASCSGPLYLAAVYGHLDCFRLLLLHGADPDYNCTD 204
PL+ AA GH D LLL +GA P+ +D
Sbjct: 736 ----SPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 766
Score = 66.6 bits (161), Expect = 3e-11
Identities = 55/180 (30%), Positives = 83/180 (46%), Gaps = 19/180 (10%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL +AA GH + LL + A V++ QTPL A GH + V++LLE A+P
Sbjct: 439 TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 498
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+ +P+ AAR+G V + LL+ A K PL++AA YG +
Sbjct: 499 ATTAGHTPLHIAAREGHVETVLALLEKEASQACMTK---------KGFTPLHVAAKYGKV 549
Query: 186 DCFRLLLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNCEPEYIQLLIDFGANIYLPS 245
LLL A P+ A T L + +HHN + ++LL+ G + + P+
Sbjct: 550 RVAELLLERDAHPN---------AAGKNGLTPLHVAVHHN-NLDIVKLLLPRGGSPHSPA 599
Score = 59.7 bits (143), Expect = 3e-09
Identities = 44/155 (28%), Positives = 78/155 (50%), Gaps = 20/155 (12%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
T L +AA G ++ L+ +GA+V++ K TPL+ A HL+ V+ LLE GA+
Sbjct: 80 TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVK-AKLPVWASN---------------- 168
+ + +P+ A + G ++ L+++G + V+ L + A N
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNP 199
Query: 169 -IASCSG--PLYLAAVYGHLDCFRLLLLHGADPDY 200
+ S +G PL++AA Y +L+ +LLL GA ++
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 234
Score = 57.4 bits (137), Expect = 2e-08
Identities = 30/84 (35%), Positives = 47/84 (55%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL +A+ YG++ ++ LL H ADV++ +PL A GH D V +LL+ GASP
Sbjct: 703 TPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 762
Query: 126 SIYNNCSPVLTAARDGAVAILQEL 149
+ +P+ A R G +++ L
Sbjct: 763 VSSDGTTPLAIAKRLGYISVTDVL 786
Score = 53.5 bits (127), Expect = 2e-07
Identities = 38/134 (28%), Positives = 58/134 (43%), Gaps = 9/134 (6%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL +A + +L +++LL G S TPL A ++ R LL+ G S
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+P+ AA++G ++ LL A N+ K S PL+L A GH+
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNK---------SGLTPLHLVAQEGHV 681
Query: 186 DCFRLLLLHGADPD 199
+L+ HG D
Sbjct: 682 PVADVLIKHGVMVD 695
Score = 49.7 bits (117), Expect = 3e-06
Identities = 51/200 (25%), Positives = 87/200 (43%), Gaps = 21/200 (10%)
Query: 71 AASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNN 130
AA G+L L +G D+++ + L A GH+ V LL +
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 131 CSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDCFRL 190
+ + AA G +++EL+++GA N +++ PLY+AA HL+ +
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQ---------KGFTPLYMAAQENHLEVVKF 129
Query: 191 LLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNCEPEYIQLLIDFG--ANIYLPSLSL 248
LL +GA+ + T+ G T L + L E + LI++G + LP+L +
Sbjct: 130 LLENGANQNV-ATEDGF--------TPLAVALQQGHE-NVVAHLINYGTKGKVRLPALHI 179
Query: 249 DLTSQDDKGIALLLQARATP 268
+ D + A+LLQ P
Sbjct: 180 AARNDDTRTAAVLLQNDPNP 199
Score = 48.9 bits (115), Expect = 6e-06
Identities = 60/214 (28%), Positives = 91/214 (42%), Gaps = 14/214 (6%)
Query: 39 SYTLDQLLRQERYKRFINSRSGWGVPGTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQ 98
S LD+ L R IN+ + G+ G L LA+ GH+ + LL +++ K
Sbjct: 22 SGNLDKALDHLRNGVDINTCNQNGLNG--LHLASKEGHVKMVVELLHKEIILETTTKKGN 79
Query: 99 TPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAEANV 158
T L A G + VR L+ GA+ +P+ AA++ + +++ LL++GA NV
Sbjct: 80 TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139
Query: 159 KAKLPVWASNIASCSGPLYLAA---VYGHLDCFRLLLLH-GADPDYNCTDQGLLARVPRP 214
+ +A G + A YG RL LH A D T LL P P
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNP 199
Query: 215 RTL-------LEICLHHNCEPEYIQLLIDFGANI 241
L L I H+ QLL++ GA++
Sbjct: 200 DVLSKTGFTPLHIAAHYE-NLNVAQLLLNRGASV 232
>gi|13443014 ankyrin repeat and SOCS box-containing 9 isoform 2
[Homo sapiens]
Length = 262
Score = 78.6 bits (192), Expect = 7e-15
Identities = 61/177 (34%), Positives = 80/177 (45%), Gaps = 25/177 (14%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGAS--P 123
+PL A GHLSC+++LL HGA V+ + TPLF A G DCV +LL+ GAS P
Sbjct: 71 SPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQP 130
Query: 124 GGSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYG 183
+ SP+ AAR G V + L+ +G + K I+ PLYLA
Sbjct: 131 ESDL---ASPIHEAARRGHVECVNSLIAYGGNIDHK---------ISHLGTPLYLACENQ 178
Query: 184 HLDCFRLLLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNCEPEYIQLLIDFGAN 240
C + LL GAD + L V R E LL+DFGA+
Sbjct: 179 QRACVKKLLESGADVNQGKGQDSPLHAVAR-----------TASEELACLLMDFGAD 224
Score = 67.0 bits (162), Expect = 2e-11
Identities = 41/141 (29%), Positives = 70/141 (49%), Gaps = 10/141 (7%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
+P+ AA +GH L+ L++ G V+ + +PL A GHL CV++LL+ GA G
Sbjct: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+ +P+ A G+ + LL HGA ++ L + P++ AA GH+
Sbjct: 98 VTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDL----------ASPIHEAARRGHV 147
Query: 186 DCFRLLLLHGADPDYNCTDQG 206
+C L+ +G + D+ + G
Sbjct: 148 ECVNSLIAYGGNIDHKISHLG 168
>gi|22208951 ankyrin repeat and SOCS box-containing protein 3
isoform b [Homo sapiens]
Length = 445
Score = 78.6 bits (192), Expect = 7e-15
Identities = 55/172 (31%), Positives = 79/172 (45%), Gaps = 45/172 (26%)
Query: 68 LRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSI 127
L LAAS GH +Q+LL GAD ++ ++ TPLF AV +G +D +R+LL+ GA+ GS
Sbjct: 10 LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGS- 68
Query: 128 YNNC-----------------------------------SPVLTAARDGAVAILQELLDH 152
++ C +P+ AA+ G + L L+
Sbjct: 69 HSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISS 128
Query: 153 GAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDCFRLLLLHGADPDYNCTD 204
GA N +A + PL++AA GH C LLL GADPD C +
Sbjct: 129 GANVNCQA---------LDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNE 171
Score = 76.3 bits (186), Expect = 3e-14
Identities = 59/180 (32%), Positives = 87/180 (48%), Gaps = 30/180 (16%)
Query: 29 ALNQAVYDNDSYTLDQLLRQERYKRFINSRSGWGVPGTPLRLAASYGHLSCLQVLLAHGA 88
+L+QA + ++ + LLR+ K + +G+ TPL +AA YG L L +L++ GA
Sbjct: 76 SLHQASFQENAEIIKLLLRKGANKE---CQDDFGI--TPLFVAAQYGKLESLSILISSGA 130
Query: 89 DVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNCS----PVLTAARDGAVA 144
+V+ + TPLF A GH CV +LL +GA P +Y N P+ AA+ G
Sbjct: 131 NVNCQALDKATPLFIAAQEGHTKCVELLLSSGADP--DLYCNEDSWQLPIHAAAQMGHTK 188
Query: 145 ILQELLDHGAEANVKAKLPVWASNIASCSG-----PLYLAAVYGHLDCFRLLLLHGADPD 199
IL L+ +N A +G P+Y A GH DC +LL +G PD
Sbjct: 189 ILDLLIP--------------LTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPD 234
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 75.1 bits (183), Expect = 7e-14
Identities = 49/132 (37%), Positives = 66/132 (50%), Gaps = 9/132 (6%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL +AA YG L ++LL A DS TPL A + + +LLE GASP
Sbjct: 544 TPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHA 603
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+ N +P+ AA+ + I LL++GAE N+ K V PL+LA+ GH
Sbjct: 604 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV---------TPLHLASQEGHT 654
Query: 186 DCFRLLLLHGAD 197
D LLL GA+
Sbjct: 655 DMVTLLLDKGAN 666
Score = 70.5 bits (171), Expect = 2e-12
Identities = 54/193 (27%), Positives = 94/193 (48%), Gaps = 14/193 (7%)
Query: 12 LLQPDKEEEDTDTEEKQALNQAVYDNDSYTLDQLLRQERYKRFINSRSGWGVPGTPLRLA 71
LLQ +D + AL+ A + Y + +LL +R + +G+ TPL +A
Sbjct: 330 LLQHKAPVDDVTLDYLTALHVAAHCGH-YRVTKLLLDKRANPNARALNGF----TPLHIA 384
Query: 72 ASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNC 131
+ +++L+ +GA + ++ TP+ A GHL+ V +LL+ GASP +
Sbjct: 385 CKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGE 444
Query: 132 SPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDCFRLL 191
+ + AAR G V +++ LL +GA + +A+ PL++A+ G + +LL
Sbjct: 445 TALHMAARAGQVEVVRCLLRNGALVDARAR---------EEQTPLHIASRLGKTEIVQLL 495
Query: 192 LLHGADPDYNCTD 204
L H A PD T+
Sbjct: 496 LQHMAHPDAATTN 508
Score = 69.7 bits (169), Expect = 3e-12
Identities = 41/134 (30%), Positives = 67/134 (50%), Gaps = 9/134 (6%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
+PL +AA H+ C++ LL H A VD + + T L A GH ++LL+ A+P
Sbjct: 313 SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNA 372
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
N +P+ A + + +++ L+ +GA + S P+++AA GHL
Sbjct: 373 RALNGFTPLHIACKKNRIKVMELLVKYGASIQAITE---------SGLTPIHVAAFMGHL 423
Query: 186 DCFRLLLLHGADPD 199
+ LLL +GA PD
Sbjct: 424 NIVLLLLQNGASPD 437
Score = 68.9 bits (167), Expect = 5e-12
Identities = 55/187 (29%), Positives = 90/187 (48%), Gaps = 19/187 (10%)
Query: 21 DTDTEEK---QALNQAVYDNDSYTLDQLLRQE-----RYKRFINSRSGWGVPGTPLRLAA 72
+ DT+ K AL+ A +D+ + LL+ + + K +N + G TPL +AA
Sbjct: 163 ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGF--TPLHIAA 220
Query: 73 SYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNCS 132
YG+++ +LL GA VD TPL A G+ + V++LL+ G + +
Sbjct: 221 HYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLT 280
Query: 133 PVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDCFRLLL 192
P+ AAR G +++ LL+ GA + K + PL++AA H++C + LL
Sbjct: 281 PLHCAARSGHDQVVELLLERGAPLLARTK---------NGLSPLHMAAQGDHVECVKHLL 331
Query: 193 LHGADPD 199
H A D
Sbjct: 332 QHKAPVD 338
Score = 68.6 bits (166), Expect = 7e-12
Identities = 65/258 (25%), Positives = 109/258 (42%), Gaps = 37/258 (14%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL +A+ G +Q+LL H A D+ TPL + G +D VLLEAGA+
Sbjct: 478 TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSL 537
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+ +P+ AA+ G++ + + LL A A+ K + PL++AA Y +
Sbjct: 538 ATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK---------NGLTPLHVAAHYDNQ 588
Query: 186 DCFRLLLLHGADPDYNCTDQGLLARVPRPRTLLEIC---LHHNCE--------------- 227
LLL GA P + + + ++I L++ E
Sbjct: 589 KVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLA 648
Query: 228 -----PEYIQLLIDFGANIYLPS----LSLDLTSQDDK-GIALLLQARATPRSLLSQVRL 277
+ + LL+D GANI++ + SL L +Q+DK +A +L + +++
Sbjct: 649 SQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGY 708
Query: 278 VVRRALCQAGQPQAINQL 295
C G + +N L
Sbjct: 709 TPLIVACHYGNVKMVNFL 726
Score = 62.8 bits (151), Expect = 4e-10
Identities = 50/158 (31%), Positives = 73/158 (46%), Gaps = 24/158 (15%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TP+ +AA GHL+ + +LL +GA D +++ +T L A G ++ VR LL GA
Sbjct: 412 TPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDA 471
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAE---ANVKAKLPVW----------------- 165
+P+ A+R G I+Q LL H A A P+
Sbjct: 472 RAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEA 531
Query: 166 --ASNIASCSG--PLYLAAVYGHLDCFRLLLLHGADPD 199
A ++A+ G PL++AA YG LD +LLL A D
Sbjct: 532 GAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 569
Score = 61.2 bits (147), Expect = 1e-09
Identities = 50/166 (30%), Positives = 80/166 (48%), Gaps = 34/166 (20%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
T L +A+ G ++VL+ GA++++ TPL+ A H+D V+ LLE GA+
Sbjct: 78 TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQST 137
Query: 126 SIYNNCSPVLTAARDG---AVAILQE--------------------------LLDHGAEA 156
+ + +P+ A + G AVAIL E LL + A
Sbjct: 138 ATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNA 197
Query: 157 NVKAKLPVWASNIASCSG--PLYLAAVYGHLDCFRLLLLHGADPDY 200
+V++K+ V N + SG PL++AA YG+++ LLL GA D+
Sbjct: 198 DVQSKMMV---NRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDF 240
Score = 58.9 bits (141), Expect = 5e-09
Identities = 40/134 (29%), Positives = 58/134 (43%), Gaps = 9/134 (6%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL LA+ GH + +LL GA++ T L A ++ +L + GA
Sbjct: 643 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 702
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+P++ A G V ++ LL GA N K K + PL+ AA GH
Sbjct: 703 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTK---------NGYTPLHQAAQQGHT 753
Query: 186 DCFRLLLLHGADPD 199
+LL HGA P+
Sbjct: 754 HIINVLLQHGAKPN 767
Score = 58.2 bits (139), Expect = 9e-09
Identities = 38/125 (30%), Positives = 60/125 (48%), Gaps = 9/125 (7%)
Query: 68 LRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSI 127
L LAA GH+ +Q LL G+ VDS K T L A G + V+VL++ GA+
Sbjct: 47 LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS 106
Query: 128 YNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDC 187
N +P+ AA++ + +++ LL++GA + + PL +A GH
Sbjct: 107 QNGFTPLYMAAQENHIDVVKYLLENGANQSTATE---------DGFTPLAVALQQGHNQA 157
Query: 188 FRLLL 192
+LL
Sbjct: 158 VAILL 162
Score = 55.8 bits (133), Expect = 5e-08
Identities = 53/195 (27%), Positives = 85/195 (43%), Gaps = 21/195 (10%)
Query: 71 AASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNN 130
AA G+L + L G D+++ + L A GH+ V+ LL G+S +
Sbjct: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76
Query: 131 CSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDCFRL 190
+ + A+ G +++ L+ GA N +++ + PLY+AA H+D +
Sbjct: 77 NTALHIASLAGQAEVVKVLVKEGANINAQSQ---------NGFTPLYMAAQENHIDVVKY 127
Query: 191 LLLHGADPDYNCTDQGLLARVPRPRTLLEICLH--HNCEPEYIQLLIDFGANIYLPSLSL 248
LL +GA+ T+ G T L + L HN + I L D + LP+L +
Sbjct: 128 LLENGANQS-TATEDGF--------TPLAVALQQGHN-QAVAILLENDTKGKVRLPALHI 177
Query: 249 DLTSQDDKGIALLLQ 263
D K ALLLQ
Sbjct: 178 AARKDDTKSAALLLQ 192
Score = 54.3 bits (129), Expect = 1e-07
Identities = 28/84 (33%), Positives = 44/84 (52%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL +A YG++ + LL GA+V++ TPL A GH + VLL+ GA P
Sbjct: 709 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 768
Query: 126 SIYNNCSPVLTAARDGAVAILQEL 149
+ N + + A R G ++++ L
Sbjct: 769 TTANGNTALAIAKRLGYISVVDTL 792
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 75.1 bits (183), Expect = 7e-14
Identities = 49/132 (37%), Positives = 66/132 (50%), Gaps = 9/132 (6%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL +AA YG L ++LL A DS TPL A + + +LLE GASP
Sbjct: 565 TPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHA 624
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+ N +P+ AA+ + I LL++GAE N+ K V PL+LA+ GH
Sbjct: 625 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV---------TPLHLASQEGHT 675
Query: 186 DCFRLLLLHGAD 197
D LLL GA+
Sbjct: 676 DMVTLLLDKGAN 687
Score = 70.5 bits (171), Expect = 2e-12
Identities = 54/193 (27%), Positives = 94/193 (48%), Gaps = 14/193 (7%)
Query: 12 LLQPDKEEEDTDTEEKQALNQAVYDNDSYTLDQLLRQERYKRFINSRSGWGVPGTPLRLA 71
LLQ +D + AL+ A + Y + +LL +R + +G+ TPL +A
Sbjct: 351 LLQHKAPVDDVTLDYLTALHVAAHCGH-YRVTKLLLDKRANPNARALNGF----TPLHIA 405
Query: 72 ASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNC 131
+ +++L+ +GA + ++ TP+ A GHL+ V +LL+ GASP +
Sbjct: 406 CKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGE 465
Query: 132 SPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDCFRLL 191
+ + AAR G V +++ LL +GA + +A+ PL++A+ G + +LL
Sbjct: 466 TALHMAARAGQVEVVRCLLRNGALVDARAR---------EEQTPLHIASRLGKTEIVQLL 516
Query: 192 LLHGADPDYNCTD 204
L H A PD T+
Sbjct: 517 LQHMAHPDAATTN 529
Score = 69.7 bits (169), Expect = 3e-12
Identities = 41/134 (30%), Positives = 67/134 (50%), Gaps = 9/134 (6%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
+PL +AA H+ C++ LL H A VD + + T L A GH ++LL+ A+P
Sbjct: 334 SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNA 393
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
N +P+ A + + +++ L+ +GA + S P+++AA GHL
Sbjct: 394 RALNGFTPLHIACKKNRIKVMELLVKYGASIQAITE---------SGLTPIHVAAFMGHL 444
Query: 186 DCFRLLLLHGADPD 199
+ LLL +GA PD
Sbjct: 445 NIVLLLLQNGASPD 458
Score = 68.9 bits (167), Expect = 5e-12
Identities = 55/187 (29%), Positives = 90/187 (48%), Gaps = 19/187 (10%)
Query: 21 DTDTEEK---QALNQAVYDNDSYTLDQLLRQE-----RYKRFINSRSGWGVPGTPLRLAA 72
+ DT+ K AL+ A +D+ + LL+ + + K +N + G TPL +AA
Sbjct: 184 ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGF--TPLHIAA 241
Query: 73 SYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNCS 132
YG+++ +LL GA VD TPL A G+ + V++LL+ G + +
Sbjct: 242 HYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLT 301
Query: 133 PVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDCFRLLL 192
P+ AAR G +++ LL+ GA + K + PL++AA H++C + LL
Sbjct: 302 PLHCAARSGHDQVVELLLERGAPLLARTK---------NGLSPLHMAAQGDHVECVKHLL 352
Query: 193 LHGADPD 199
H A D
Sbjct: 353 QHKAPVD 359
Score = 68.6 bits (166), Expect = 7e-12
Identities = 65/258 (25%), Positives = 109/258 (42%), Gaps = 37/258 (14%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL +A+ G +Q+LL H A D+ TPL + G +D VLLEAGA+
Sbjct: 499 TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSL 558
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+ +P+ AA+ G++ + + LL A A+ K + PL++AA Y +
Sbjct: 559 ATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK---------NGLTPLHVAAHYDNQ 609
Query: 186 DCFRLLLLHGADPDYNCTDQGLLARVPRPRTLLEIC---LHHNCE--------------- 227
LLL GA P + + + ++I L++ E
Sbjct: 610 KVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLA 669
Query: 228 -----PEYIQLLIDFGANIYLPS----LSLDLTSQDDK-GIALLLQARATPRSLLSQVRL 277
+ + LL+D GANI++ + SL L +Q+DK +A +L + +++
Sbjct: 670 SQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGY 729
Query: 278 VVRRALCQAGQPQAINQL 295
C G + +N L
Sbjct: 730 TPLIVACHYGNVKMVNFL 747
Score = 62.8 bits (151), Expect = 4e-10
Identities = 50/158 (31%), Positives = 73/158 (46%), Gaps = 24/158 (15%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TP+ +AA GHL+ + +LL +GA D +++ +T L A G ++ VR LL GA
Sbjct: 433 TPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDA 492
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAE---ANVKAKLPVW----------------- 165
+P+ A+R G I+Q LL H A A P+
Sbjct: 493 RAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEA 552
Query: 166 --ASNIASCSG--PLYLAAVYGHLDCFRLLLLHGADPD 199
A ++A+ G PL++AA YG LD +LLL A D
Sbjct: 553 GAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 590
Score = 61.2 bits (147), Expect = 1e-09
Identities = 50/166 (30%), Positives = 80/166 (48%), Gaps = 34/166 (20%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
T L +A+ G ++VL+ GA++++ TPL+ A H+D V+ LLE GA+
Sbjct: 99 TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQST 158
Query: 126 SIYNNCSPVLTAARDG---AVAILQE--------------------------LLDHGAEA 156
+ + +P+ A + G AVAIL E LL + A
Sbjct: 159 ATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNA 218
Query: 157 NVKAKLPVWASNIASCSG--PLYLAAVYGHLDCFRLLLLHGADPDY 200
+V++K+ V N + SG PL++AA YG+++ LLL GA D+
Sbjct: 219 DVQSKMMV---NRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDF 261
Score = 58.9 bits (141), Expect = 5e-09
Identities = 40/134 (29%), Positives = 58/134 (43%), Gaps = 9/134 (6%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL LA+ GH + +LL GA++ T L A ++ +L + GA
Sbjct: 664 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 723
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+P++ A G V ++ LL GA N K K + PL+ AA GH
Sbjct: 724 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTK---------NGYTPLHQAAQQGHT 774
Query: 186 DCFRLLLLHGADPD 199
+LL HGA P+
Sbjct: 775 HIINVLLQHGAKPN 788
Score = 58.2 bits (139), Expect = 9e-09
Identities = 38/125 (30%), Positives = 60/125 (48%), Gaps = 9/125 (7%)
Query: 68 LRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSI 127
L LAA GH+ +Q LL G+ VDS K T L A G + V+VL++ GA+
Sbjct: 68 LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS 127
Query: 128 YNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDC 187
N +P+ AA++ + +++ LL++GA + + PL +A GH
Sbjct: 128 QNGFTPLYMAAQENHIDVVKYLLENGANQSTATE---------DGFTPLAVALQQGHNQA 178
Query: 188 FRLLL 192
+LL
Sbjct: 179 VAILL 183
Score = 55.8 bits (133), Expect = 5e-08
Identities = 53/195 (27%), Positives = 85/195 (43%), Gaps = 21/195 (10%)
Query: 71 AASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNN 130
AA G+L + L G D+++ + L A GH+ V+ LL G+S +
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 131 CSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDCFRL 190
+ + A+ G +++ L+ GA N +++ + PLY+AA H+D +
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQSQ---------NGFTPLYMAAQENHIDVVKY 148
Query: 191 LLLHGADPDYNCTDQGLLARVPRPRTLLEICLH--HNCEPEYIQLLIDFGANIYLPSLSL 248
LL +GA+ T+ G T L + L HN + I L D + LP+L +
Sbjct: 149 LLENGANQS-TATEDGF--------TPLAVALQQGHN-QAVAILLENDTKGKVRLPALHI 198
Query: 249 DLTSQDDKGIALLLQ 263
D K ALLLQ
Sbjct: 199 AARKDDTKSAALLLQ 213
Score = 54.3 bits (129), Expect = 1e-07
Identities = 28/84 (33%), Positives = 44/84 (52%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL +A YG++ + LL GA+V++ TPL A GH + VLL+ GA P
Sbjct: 730 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 789
Query: 126 SIYNNCSPVLTAARDGAVAILQEL 149
+ N + + A R G ++++ L
Sbjct: 790 TTANGNTALAIAKRLGYISVVDTL 813
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 75.1 bits (183), Expect = 7e-14
Identities = 49/132 (37%), Positives = 66/132 (50%), Gaps = 9/132 (6%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL +AA YG L ++LL A DS TPL A + + +LLE GASP
Sbjct: 565 TPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHA 624
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+ N +P+ AA+ + I LL++GAE N+ K V PL+LA+ GH
Sbjct: 625 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV---------TPLHLASQEGHT 675
Query: 186 DCFRLLLLHGAD 197
D LLL GA+
Sbjct: 676 DMVTLLLDKGAN 687
Score = 70.5 bits (171), Expect = 2e-12
Identities = 54/193 (27%), Positives = 94/193 (48%), Gaps = 14/193 (7%)
Query: 12 LLQPDKEEEDTDTEEKQALNQAVYDNDSYTLDQLLRQERYKRFINSRSGWGVPGTPLRLA 71
LLQ +D + AL+ A + Y + +LL +R + +G+ TPL +A
Sbjct: 351 LLQHKAPVDDVTLDYLTALHVAAHCGH-YRVTKLLLDKRANPNARALNGF----TPLHIA 405
Query: 72 ASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNC 131
+ +++L+ +GA + ++ TP+ A GHL+ V +LL+ GASP +
Sbjct: 406 CKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGE 465
Query: 132 SPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDCFRLL 191
+ + AAR G V +++ LL +GA + +A+ PL++A+ G + +LL
Sbjct: 466 TALHMAARAGQVEVVRCLLRNGALVDARAR---------EEQTPLHIASRLGKTEIVQLL 516
Query: 192 LLHGADPDYNCTD 204
L H A PD T+
Sbjct: 517 LQHMAHPDAATTN 529
Score = 69.7 bits (169), Expect = 3e-12
Identities = 41/134 (30%), Positives = 67/134 (50%), Gaps = 9/134 (6%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
+PL +AA H+ C++ LL H A VD + + T L A GH ++LL+ A+P
Sbjct: 334 SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNA 393
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
N +P+ A + + +++ L+ +GA + S P+++AA GHL
Sbjct: 394 RALNGFTPLHIACKKNRIKVMELLVKYGASIQAITE---------SGLTPIHVAAFMGHL 444
Query: 186 DCFRLLLLHGADPD 199
+ LLL +GA PD
Sbjct: 445 NIVLLLLQNGASPD 458
Score = 68.9 bits (167), Expect = 5e-12
Identities = 55/187 (29%), Positives = 90/187 (48%), Gaps = 19/187 (10%)
Query: 21 DTDTEEK---QALNQAVYDNDSYTLDQLLRQE-----RYKRFINSRSGWGVPGTPLRLAA 72
+ DT+ K AL+ A +D+ + LL+ + + K +N + G TPL +AA
Sbjct: 184 ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGF--TPLHIAA 241
Query: 73 SYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNCS 132
YG+++ +LL GA VD TPL A G+ + V++LL+ G + +
Sbjct: 242 HYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLT 301
Query: 133 PVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDCFRLLL 192
P+ AAR G +++ LL+ GA + K + PL++AA H++C + LL
Sbjct: 302 PLHCAARSGHDQVVELLLERGAPLLARTK---------NGLSPLHMAAQGDHVECVKHLL 352
Query: 193 LHGADPD 199
H A D
Sbjct: 353 QHKAPVD 359
Score = 68.6 bits (166), Expect = 7e-12
Identities = 65/258 (25%), Positives = 109/258 (42%), Gaps = 37/258 (14%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL +A+ G +Q+LL H A D+ TPL + G +D VLLEAGA+
Sbjct: 499 TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSL 558
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+ +P+ AA+ G++ + + LL A A+ K + PL++AA Y +
Sbjct: 559 ATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK---------NGLTPLHVAAHYDNQ 609
Query: 186 DCFRLLLLHGADPDYNCTDQGLLARVPRPRTLLEIC---LHHNCE--------------- 227
LLL GA P + + + ++I L++ E
Sbjct: 610 KVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLA 669
Query: 228 -----PEYIQLLIDFGANIYLPS----LSLDLTSQDDK-GIALLLQARATPRSLLSQVRL 277
+ + LL+D GANI++ + SL L +Q+DK +A +L + +++
Sbjct: 670 SQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGY 729
Query: 278 VVRRALCQAGQPQAINQL 295
C G + +N L
Sbjct: 730 TPLIVACHYGNVKMVNFL 747
Score = 62.8 bits (151), Expect = 4e-10
Identities = 50/158 (31%), Positives = 73/158 (46%), Gaps = 24/158 (15%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TP+ +AA GHL+ + +LL +GA D +++ +T L A G ++ VR LL GA
Sbjct: 433 TPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDA 492
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAE---ANVKAKLPVW----------------- 165
+P+ A+R G I+Q LL H A A P+
Sbjct: 493 RAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEA 552
Query: 166 --ASNIASCSG--PLYLAAVYGHLDCFRLLLLHGADPD 199
A ++A+ G PL++AA YG LD +LLL A D
Sbjct: 553 GAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 590
Score = 61.2 bits (147), Expect = 1e-09
Identities = 50/166 (30%), Positives = 80/166 (48%), Gaps = 34/166 (20%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
T L +A+ G ++VL+ GA++++ TPL+ A H+D V+ LLE GA+
Sbjct: 99 TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQST 158
Query: 126 SIYNNCSPVLTAARDG---AVAILQE--------------------------LLDHGAEA 156
+ + +P+ A + G AVAIL E LL + A
Sbjct: 159 ATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNA 218
Query: 157 NVKAKLPVWASNIASCSG--PLYLAAVYGHLDCFRLLLLHGADPDY 200
+V++K+ V N + SG PL++AA YG+++ LLL GA D+
Sbjct: 219 DVQSKMMV---NRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDF 261
Score = 58.9 bits (141), Expect = 5e-09
Identities = 40/134 (29%), Positives = 58/134 (43%), Gaps = 9/134 (6%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL LA+ GH + +LL GA++ T L A ++ +L + GA
Sbjct: 664 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 723
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+P++ A G V ++ LL GA N K K + PL+ AA GH
Sbjct: 724 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTK---------NGYTPLHQAAQQGHT 774
Query: 186 DCFRLLLLHGADPD 199
+LL HGA P+
Sbjct: 775 HIINVLLQHGAKPN 788
Score = 58.2 bits (139), Expect = 9e-09
Identities = 38/125 (30%), Positives = 60/125 (48%), Gaps = 9/125 (7%)
Query: 68 LRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSI 127
L LAA GH+ +Q LL G+ VDS K T L A G + V+VL++ GA+
Sbjct: 68 LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS 127
Query: 128 YNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDC 187
N +P+ AA++ + +++ LL++GA + + PL +A GH
Sbjct: 128 QNGFTPLYMAAQENHIDVVKYLLENGANQSTATE---------DGFTPLAVALQQGHNQA 178
Query: 188 FRLLL 192
+LL
Sbjct: 179 VAILL 183
Score = 55.8 bits (133), Expect = 5e-08
Identities = 53/195 (27%), Positives = 85/195 (43%), Gaps = 21/195 (10%)
Query: 71 AASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNN 130
AA G+L + L G D+++ + L A GH+ V+ LL G+S +
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 131 CSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDCFRL 190
+ + A+ G +++ L+ GA N +++ + PLY+AA H+D +
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQSQ---------NGFTPLYMAAQENHIDVVKY 148
Query: 191 LLLHGADPDYNCTDQGLLARVPRPRTLLEICLH--HNCEPEYIQLLIDFGANIYLPSLSL 248
LL +GA+ T+ G T L + L HN + I L D + LP+L +
Sbjct: 149 LLENGANQS-TATEDGF--------TPLAVALQQGHN-QAVAILLENDTKGKVRLPALHI 198
Query: 249 DLTSQDDKGIALLLQ 263
D K ALLLQ
Sbjct: 199 AARKDDTKSAALLLQ 213
Score = 54.3 bits (129), Expect = 1e-07
Identities = 28/84 (33%), Positives = 44/84 (52%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL +A YG++ + LL GA+V++ TPL A GH + VLL+ GA P
Sbjct: 730 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 789
Query: 126 SIYNNCSPVLTAARDGAVAILQEL 149
+ N + + A R G ++++ L
Sbjct: 790 TTANGNTALAIAKRLGYISVVDTL 813
>gi|34304381 inversin isoform a [Homo sapiens]
Length = 1065
Score = 74.3 bits (181), Expect = 1e-13
Identities = 72/241 (29%), Positives = 111/241 (46%), Gaps = 30/241 (12%)
Query: 2 NLMDITKIFSLLQPDKEEEDTDTEEKQALNQAVYDNDSYTLDQLLRQERYKRFINSRSGW 61
N + K+F L+ ++D+D E + + A L +L + IN +
Sbjct: 300 NFAETVKVF--LKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKS-DIDINMADKY 356
Query: 62 GVPGTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGA 121
G GT L AA GH+S +++LL + A VD+ DV TPLF A GH D ++ L++ GA
Sbjct: 357 G--GTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGA 414
Query: 122 SPGGSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAV 181
+ S + AA G + Q L+++ NV+ +A PL AA
Sbjct: 415 RVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQD----YAGRT-----PLQCAAY 465
Query: 182 YGHLDCFRLLLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNCEPEY---IQLLIDFG 238
G+++C +L+ + ADP N D+ RT LH +C Y I+LL+DF
Sbjct: 466 GGYINCMAVLMENNADP--NIQDK-------EGRT----ALHWSCNNGYLDAIKLLLDFA 512
Query: 239 A 239
A
Sbjct: 513 A 513
Score = 51.2 bits (121), Expect = 1e-06
Identities = 29/91 (31%), Positives = 53/91 (58%), Gaps = 2/91 (2%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL+ AA G+++C+ VL+ + AD + D + +T L + ++G+LD +++LL+ A P
Sbjct: 458 TPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQ 517
Query: 126 SIYN--NCSPVLTAARDGAVAILQELLDHGA 154
N +P+ A ++Q +L+HGA
Sbjct: 518 MENNEERYTPLDYALLGERHEVIQFMLEHGA 548
Score = 48.1 bits (113), Expect = 1e-05
Identities = 47/177 (26%), Positives = 75/177 (42%), Gaps = 18/177 (10%)
Query: 71 AASYGHLSCLQ-VLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYN 129
AA G LQ +++ + A D D +TPL V LDC LL+AGA + ++
Sbjct: 21 AAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHS 80
Query: 130 NCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDCFR 189
+ + AA+ G ++ LL A W PL+L + C
Sbjct: 81 QRTALHLAAQKGNYRFMKLLLTRRAN---------WMQKDLEEMTPLHLTTRHRSPKCLA 131
Query: 190 LLLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNCEPEYIQLLIDFGANIYLPSL 246
LLL A + + D+ +T L ++N PE+++LLI +NI +P +
Sbjct: 132 LLLKFMAPGEVDTQDK-------NKQTALHWSAYYN-NPEHVKLLIKHDSNIGIPDV 180
Score = 40.4 bits (93), Expect = 0.002
Identities = 58/220 (26%), Positives = 94/220 (42%), Gaps = 51/220 (23%)
Query: 66 TPLRLAASYGHLSCLQVLLAH-GADVDSLDVKAQTPLFTAVSHGHLDCVRVLLE---AGA 121
TPL A + G+++ + VL ++ ++ S D +TPL A GH V +LLE +G
Sbjct: 223 TPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGT 282
Query: 122 SPGGSIYNNCSPVLTAARDGAVAILQELLDHGA---EANVKAKLP-VWAS---------- 167
P S +P+ AA+ ++ L H + +++++ + +WA+
Sbjct: 283 IPSDS--QGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRT 340
Query: 168 ----------NIASCSG--PLYLAAVYGHLDCFRLLLLHGADPDYNCTDQGLLARVPRPR 215
N+A G L+ AA+ GH+ +LLL + A D TD V +
Sbjct: 341 MLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVD--ATD------VMKHT 392
Query: 216 TLLEIC-LHHNCEPEYIQLLIDFGANIYLPSLSLDLTSQD 254
L C + H + IQ LI GA + DL QD
Sbjct: 393 PLFRACEMGHK---DVIQTLIKGGARV-------DLVDQD 422
>gi|34304379 inversin isoform b [Homo sapiens]
Length = 895
Score = 74.3 bits (181), Expect = 1e-13
Identities = 72/241 (29%), Positives = 111/241 (46%), Gaps = 30/241 (12%)
Query: 2 NLMDITKIFSLLQPDKEEEDTDTEEKQALNQAVYDNDSYTLDQLLRQERYKRFINSRSGW 61
N + K+F L+ ++D+D E + + A L +L + IN +
Sbjct: 300 NFAETVKVF--LKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKS-DIDINMADKY 356
Query: 62 GVPGTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGA 121
G GT L AA GH+S +++LL + A VD+ DV TPLF A GH D ++ L++ GA
Sbjct: 357 G--GTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGA 414
Query: 122 SPGGSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAV 181
+ S + AA G + Q L+++ NV+ +A PL AA
Sbjct: 415 RVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQD----YAGRT-----PLQCAAY 465
Query: 182 YGHLDCFRLLLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNCEPEY---IQLLIDFG 238
G+++C +L+ + ADP N D+ RT LH +C Y I+LL+DF
Sbjct: 466 GGYINCMAVLMENNADP--NIQDK-------EGRT----ALHWSCNNGYLDAIKLLLDFA 512
Query: 239 A 239
A
Sbjct: 513 A 513
Score = 51.2 bits (121), Expect = 1e-06
Identities = 29/91 (31%), Positives = 53/91 (58%), Gaps = 2/91 (2%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL+ AA G+++C+ VL+ + AD + D + +T L + ++G+LD +++LL+ A P
Sbjct: 458 TPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQ 517
Query: 126 SIYN--NCSPVLTAARDGAVAILQELLDHGA 154
N +P+ A ++Q +L+HGA
Sbjct: 518 MENNEERYTPLDYALLGERHEVIQFMLEHGA 548
Score = 48.1 bits (113), Expect = 1e-05
Identities = 47/177 (26%), Positives = 75/177 (42%), Gaps = 18/177 (10%)
Query: 71 AASYGHLSCLQ-VLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYN 129
AA G LQ +++ + A D D +TPL V LDC LL+AGA + ++
Sbjct: 21 AAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHS 80
Query: 130 NCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDCFR 189
+ + AA+ G ++ LL A W PL+L + C
Sbjct: 81 QRTALHLAAQKGNYRFMKLLLTRRAN---------WMQKDLEEMTPLHLTTRHRSPKCLA 131
Query: 190 LLLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNCEPEYIQLLIDFGANIYLPSL 246
LLL A + + D+ +T L ++N PE+++LLI +NI +P +
Sbjct: 132 LLLKFMAPGEVDTQDK-------NKQTALHWSAYYN-NPEHVKLLIKHDSNIGIPDV 180
Score = 40.4 bits (93), Expect = 0.002
Identities = 58/220 (26%), Positives = 94/220 (42%), Gaps = 51/220 (23%)
Query: 66 TPLRLAASYGHLSCLQVLLAH-GADVDSLDVKAQTPLFTAVSHGHLDCVRVLLE---AGA 121
TPL A + G+++ + VL ++ ++ S D +TPL A GH V +LLE +G
Sbjct: 223 TPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGT 282
Query: 122 SPGGSIYNNCSPVLTAARDGAVAILQELLDHGA---EANVKAKLP-VWAS---------- 167
P S +P+ AA+ ++ L H + +++++ + +WA+
Sbjct: 283 IPSDS--QGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRT 340
Query: 168 ----------NIASCSG--PLYLAAVYGHLDCFRLLLLHGADPDYNCTDQGLLARVPRPR 215
N+A G L+ AA+ GH+ +LLL + A D TD V +
Sbjct: 341 MLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVD--ATD------VMKHT 392
Query: 216 TLLEIC-LHHNCEPEYIQLLIDFGANIYLPSLSLDLTSQD 254
L C + H + IQ LI GA + DL QD
Sbjct: 393 PLFRACEMGHK---DVIQTLIKGGARV-------DLVDQD 422
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 73.9 bits (180), Expect = 2e-13
Identities = 62/238 (26%), Positives = 102/238 (42%), Gaps = 34/238 (14%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
+PL +A HL+C+Q+LL H VD + T L A GH +VLL+ A+P
Sbjct: 336 SPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNA 395
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
N +P+ A + + +++ LL HGA + S P+++AA GH+
Sbjct: 396 KALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTE---------SGLTPIHVAAFMGHV 446
Query: 186 DCFRLLLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNCEPEYIQLLIDFGANIYLPS 245
+ L+ HGA P N T+ R T L + + E ++ L+ GA +
Sbjct: 447 NIVSQLMHHGASP--NTTN-------VRGETALHMAARSG-QAEVVRYLVQDGAQV---- 492
Query: 246 LSLDLTSQDDKGIALLLQARATPRSLLSQVRLVVRRALCQAGQPQAINQLDIPPMLIS 303
+ ++DD+ L + AR ++ Q+ L Q P A P+ +S
Sbjct: 493 ---EAKAKDDQ-TPLHISARLGKADIVQQL-------LQQGASPNAATTSGYTPLHLS 539
Score = 72.4 bits (176), Expect = 5e-13
Identities = 67/225 (29%), Positives = 97/225 (43%), Gaps = 29/225 (12%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
T L +AA G ++ L+ GA V++ QTPL + G D V+ LL+ GASP
Sbjct: 468 TALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNA 527
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+ + +P+ +AR+G + LLDHGA ++ K PL++AA YG L
Sbjct: 528 ATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTK---------KGFTPLHVAAKYGKL 578
Query: 186 DCFRLLLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNCEPEYIQLLIDFGA------ 239
+ LLL A PD A T L + H++ + LL+D GA
Sbjct: 579 EVANLLLQKSASPD---------AAGKSGLTPLHVAAHYD-NQKVALLLLDQGASPHAAA 628
Query: 240 -NIYLPSLSLDLTSQDDKGIALL---LQARATPRSLLSQVRLVVR 280
N Y P +Q D LL A A R ++ V L +
Sbjct: 629 KNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQ 673
Score = 69.7 bits (169), Expect = 3e-12
Identities = 55/182 (30%), Positives = 86/182 (47%), Gaps = 17/182 (9%)
Query: 21 DTDTEEK---QALNQAVYDNDSYTLDQLLRQERYKRFINSRSGWGVPGTPLRLAASYGHL 77
+ DT+ K AL+ A +D+ LL+ + + S+SG+ TPL +AA YG++
Sbjct: 194 ENDTKGKVRLPALHIAARKDDTKAAALLLQNDN-NADVESKSGF----TPLHIAAHYGNI 248
Query: 78 SCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNCSPVLTA 137
+ +LL A VD TPL A G+ + V++LL+ GA + +P+
Sbjct: 249 NVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCG 308
Query: 138 ARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDCFRLLLLHGAD 197
AR G +++ LLD A K K + PL++A HL+C +LLL H
Sbjct: 309 ARSGHEQVVEMLLDRAAPILSKTK---------NGLSPLHMATQGDHLNCVQLLLQHNVP 359
Query: 198 PD 199
D
Sbjct: 360 VD 361
Score = 68.2 bits (165), Expect = 9e-12
Identities = 47/132 (35%), Positives = 66/132 (50%), Gaps = 9/132 (6%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL +AA YG L +LL A D+ TPL A + + +LL+ GASP
Sbjct: 567 TPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHA 626
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+ N +P+ AA+ + I LL++GA+AN V IAS ++LAA GH+
Sbjct: 627 AAKNGYTPLHIAAKKNQMDIATTLLEYGADANA-----VTRQGIAS----VHLAAQEGHV 677
Query: 186 DCFRLLLLHGAD 197
D LLL A+
Sbjct: 678 DMVSLLLGRNAN 689
Score = 59.3 bits (142), Expect = 4e-09
Identities = 52/196 (26%), Positives = 88/196 (44%), Gaps = 30/196 (15%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
T L +A+ G ++VL+ +GA+V++ TPL+ A HL+ V+ LL+ GAS
Sbjct: 109 TALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSL 168
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVK---------------AKLPVWASN-- 168
+ + +P+ A + G ++ LL++ + V+ A L + N
Sbjct: 169 ATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNA 228
Query: 169 -IASCSG--PLYLAAVYGHLDCFRLLLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHN 225
+ S SG PL++AA YG+++ LLL A D+ + V R
Sbjct: 229 DVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRG--------- 279
Query: 226 CEPEYIQLLIDFGANI 241
++LL+D GA I
Sbjct: 280 -NANMVKLLLDRGAKI 294
Score = 58.2 bits (139), Expect = 9e-09
Identities = 43/164 (26%), Positives = 75/164 (45%), Gaps = 15/164 (9%)
Query: 33 AVYDNDSYTLDQLLRQERYKRFINSRSGWGVPGTPLRLAASYGHLSCLQVLLAHGADVDS 92
A YDN L LL + +++G+ TPL +AA + LL +GAD ++
Sbjct: 606 AHYDNQKVAL--LLLDQGASPHAAAKNGY----TPLHIAAKKNQMDIATTLLEYGADANA 659
Query: 93 LDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNCSPVLTAARDGAVAILQELLDH 152
+ + + A GH+D V +LL A+ S + +P+ AA++ V + + L++
Sbjct: 660 VTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQ 719
Query: 153 GAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDCFRLLLLHGA 196
GA + + K+ PL++ YG++ LL H A
Sbjct: 720 GAHVDAQTKMGY---------TPLHVGCHYGNIKIVNFLLQHSA 754
Score = 55.5 bits (132), Expect = 6e-08
Identities = 37/132 (28%), Positives = 57/132 (43%), Gaps = 9/132 (6%)
Query: 68 LRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSI 127
+ LAA GH+ + +LL A+V+ + TPL A ++ VL+ GA
Sbjct: 668 VHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQT 727
Query: 128 YNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDC 187
+P+ G + I+ LL H A+ N K K + PL+ AA GH
Sbjct: 728 KMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTK---------NGYTPLHQAAQQGHTHI 778
Query: 188 FRLLLLHGADPD 199
+LL + A P+
Sbjct: 779 INVLLQNNASPN 790
Score = 55.1 bits (131), Expect = 8e-08
Identities = 50/195 (25%), Positives = 84/195 (43%), Gaps = 21/195 (10%)
Query: 71 AASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNN 130
AA GHL + +G D++ + L A GH++ V LL+ A+ +
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
Query: 131 CSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDCFRL 190
+ + A+ G +++ L+ +GA N +++ + PLY+AA HL+ +
Sbjct: 108 NTALHIASLAGQAEVVKVLVTNGANVNAQSQ---------NGFTPLYMAAQENHLEVVKF 158
Query: 191 LLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNCEPEYIQLLI--DFGANIYLPSLSL 248
LL +GA T+ G T L + L + + LL+ D + LP+L +
Sbjct: 159 LLDNGASQSL-ATEDGF--------TPLAVALQQG-HDQVVSLLLENDTKGKVRLPALHI 208
Query: 249 DLTSQDDKGIALLLQ 263
D K ALLLQ
Sbjct: 209 AARKDDTKAAALLLQ 223
Score = 53.1 bits (126), Expect = 3e-07
Identities = 39/127 (30%), Positives = 62/127 (48%), Gaps = 13/127 (10%)
Query: 68 LRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSI 127
L LA+ GH+ + LL A+VD+ K T L A G + V+VL+ GA+
Sbjct: 78 LHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQS 137
Query: 128 YNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSG--PLYLAAVYGHL 185
N +P+ AA++ + +++ LLD+GA + ++A+ G PL +A GH
Sbjct: 138 QNGFTPLYMAAQENHLEVVKFLLDNGA-----------SQSLATEDGFTPLAVALQQGHD 186
Query: 186 DCFRLLL 192
LLL
Sbjct: 187 QVVSLLL 193
Score = 51.2 bits (121), Expect = 1e-06
Identities = 30/92 (32%), Positives = 44/92 (47%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL LAA ++ +VL+ GA VD+ TPL +G++ V LL+ A
Sbjct: 699 TPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNA 758
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEAN 157
N +P+ AA+ G I+ LL + A N
Sbjct: 759 KTKNGYTPLHQAAQQGHTHIINVLLQNNASPN 790
Score = 50.8 bits (120), Expect = 1e-06
Identities = 40/134 (29%), Positives = 56/134 (41%), Gaps = 9/134 (6%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL +AA Y + +LL GA + TPL A +D LLE GA
Sbjct: 600 TPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANA 659
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+ V AA++G V ++ LL A N+ K S PL+LAA +
Sbjct: 660 VTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNK---------SGLTPLHLAAQEDRV 710
Query: 186 DCFRLLLLHGADPD 199
+ +L+ GA D
Sbjct: 711 NVAEVLVNQGAHVD 724
Score = 50.8 bits (120), Expect = 1e-06
Identities = 27/84 (32%), Positives = 41/84 (48%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL + YG++ + LL H A V++ TPL A GH + VLL+ ASP
Sbjct: 732 TPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNE 791
Query: 126 SIYNNCSPVLTAARDGAVAILQEL 149
N + + A R G ++++ L
Sbjct: 792 LTVNGNTALGIARRLGYISVVDTL 815
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 73.2 bits (178), Expect = 3e-13
Identities = 59/194 (30%), Positives = 89/194 (45%), Gaps = 13/194 (6%)
Query: 9 IFSLLQPDKEEEDTDTEEKQALNQAVYDNDSYTLDQLLRQ--ERYKRFINSRSGWGVPGT 66
+ +LLQ E D E + AL A Y ++ LL E ++ R+ V
Sbjct: 660 VLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAA- 718
Query: 67 PLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGS 126
L + AS GH S + +L+ GA+VD D TPL A GH+D V +LLE GA +
Sbjct: 719 -LCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHT 777
Query: 127 IYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLD 186
N +P+L AA G +++ LL GA + S + L +A+ G+++
Sbjct: 778 DNNGRTPLLAAASMGHASVVNTLLFWGAAVD---------SIDSEGRTVLSIASAQGNVE 828
Query: 187 CFRLLLLHGADPDY 200
R LL G D ++
Sbjct: 829 VVRTLLDRGLDENH 842
Score = 67.4 bits (163), Expect = 2e-11
Identities = 51/165 (30%), Positives = 80/165 (48%), Gaps = 12/165 (7%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL AAS GH S + LL GA VDS+D + +T L A + G+++ VR LL+ G
Sbjct: 783 TPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENH 842
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+P+ AA +G I + L++ GA N N P LA+ GH
Sbjct: 843 RDDAGWTPLHMAAFEGHRLICEALIEQGARTNE-------IDNDGRI--PFILASQEGHY 893
Query: 186 DCFRLLLLHGADPD---YNCTDQGLLARVPRPRTLLEICLHHNCE 227
DC ++LL + ++ D Y+ + +A + R ++E+ H +
Sbjct: 894 DCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGAD 938
Score = 65.5 bits (158), Expect = 6e-11
Identities = 41/138 (29%), Positives = 72/138 (52%), Gaps = 9/138 (6%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
T L ++ GH+ +QVL+A+ ADV++ D + ++ L +A GH+ V++L+E GA
Sbjct: 981 TALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDH 1040
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+ + + AA++G + ++Q LL+HGA+ N + A + AA GH
Sbjct: 1041 TCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRV---------AAKNGHS 1091
Query: 186 DCFRLLLLHGADPDYNCT 203
+LL +GA C+
Sbjct: 1092 QIIKLLEKYGASSLNGCS 1109
Score = 64.3 bits (155), Expect = 1e-10
Identities = 56/172 (32%), Positives = 73/172 (42%), Gaps = 33/172 (19%)
Query: 58 RSGWGVPGTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLL 117
+ GW T LR AA GH + LL G VD D ++T L A GH D V LL
Sbjct: 609 QDGW----TALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLL 664
Query: 118 EAGASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAEAN-----VKAKLPVWASNIASC 172
+ GA + + ++ AA G I++ LLDHGAE N + L V A + +
Sbjct: 665 QHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPAS 724
Query: 173 SG------------------------PLYLAAVYGHLDCFRLLLLHGADPDY 200
G PL +AA GH+D LLL GAD D+
Sbjct: 725 KGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDH 776
Score = 63.5 bits (153), Expect = 2e-10
Identities = 54/186 (29%), Positives = 88/186 (47%), Gaps = 21/186 (11%)
Query: 55 INSRSGWGVPGTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVR 114
+N + G P L + A L+ + L +GA+V++ D + +T L + GH++ V+
Sbjct: 939 VNCKDADGRP--TLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQ 996
Query: 115 VLLEAGASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSG 174
VL+ A + S + +AA G V ++Q L++HGA + A
Sbjct: 997 VLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATA-------- 1048
Query: 175 PLYLAAVYGHLDCFRLLLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNCEPEYIQLL 234
L +AA GH+D ++LL HGADP N DQ RT + + N + I+LL
Sbjct: 1049 -LCIAAQEGHIDVVQVLLEHGADP--NHADQ-------FGRTAMRVAA-KNGHSQIIKLL 1097
Query: 235 IDFGAN 240
+GA+
Sbjct: 1098 EKYGAS 1103
Score = 62.8 bits (151), Expect = 4e-10
Identities = 51/183 (27%), Positives = 80/183 (43%), Gaps = 23/183 (12%)
Query: 59 SGWGVPGTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLE 118
+GW TPL +AA GH + L+ GA + +D + P A GH DCV++LLE
Sbjct: 846 AGW----TPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLE 901
Query: 119 AGASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYL 178
++ Y+ + + AA +G I++ L HGA+ N K A LY+
Sbjct: 902 NKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKD---------ADGRPTLYI 952
Query: 179 AAVYGHLDCFRLLLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNCEPEYIQLLIDFG 238
A+ L L +GA+ + A RT L + E +Q+LI +
Sbjct: 953 LALENQLTMAEYFLENGANVE---------ASDAEGRTALHVSCWQG-HMEMVQVLIAYH 1002
Query: 239 ANI 241
A++
Sbjct: 1003 ADV 1005
Score = 60.8 bits (146), Expect = 1e-09
Identities = 57/182 (31%), Positives = 78/182 (42%), Gaps = 26/182 (14%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL LAA GH + L+ GA+++ D T L +A GH + V LL AG
Sbjct: 580 TPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDC 639
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+ ++ + + AA G I+ LL HGAE N A N + L AA GH
Sbjct: 640 ADADSRTALRAAAWGGHEDIVLNLLQHGAEVNK-------ADNEGRTA--LIAAAYMGHR 690
Query: 186 DCFRLLLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNCEP------EYIQLLIDFGA 239
+ LL HGA+ ++ D RT L + C P + LLID GA
Sbjct: 691 EIVEHLLDHGAEVNHEDVD---------GRTALSVAA--LCVPASKGHASVVSLLIDRGA 739
Query: 240 NI 241
+
Sbjct: 740 EV 741
Score = 48.9 bits (115), Expect = 6e-06
Identities = 46/166 (27%), Positives = 70/166 (42%), Gaps = 14/166 (8%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
T L AA G L + +L++ GAD++ D TPL A GH V L+ GA+
Sbjct: 547 TLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINH 606
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+ + + + +AA G ++ LL G + + A L AA GH
Sbjct: 607 TDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCAD---------ADSRTALRAAAWGGHE 657
Query: 186 DCFRLLLLHGADPDYNCTDQGLLARVPRP----RTLLEICLHHNCE 227
D LL HGA+ + ++G A + R ++E L H E
Sbjct: 658 DIVLNLLQHGAEVN-KADNEGRTALIAAAYMGHREIVEHLLDHGAE 702
Score = 40.8 bits (94), Expect = 0.002
Identities = 42/144 (29%), Positives = 64/144 (44%), Gaps = 16/144 (11%)
Query: 65 GTPLRLAASY---GHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGA 121
GTP+R + S LQ+L+ GA V+S D + + A+ D +R LL+ GA
Sbjct: 479 GTPVRDSLSTLIPKEQEVLQLLVKAGAHVNSEDDRTSCIVRQALERE--DSIRTLLDNGA 536
Query: 122 SPGGSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAV 181
S N + + AA G++ ++ L+ GA+ ++ A PL LAA
Sbjct: 537 SVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIED---------AHGHTPLTLAAR 587
Query: 182 YGHLDCFRLLLLHGADPDYNCTDQ 205
GH L+ G + N TDQ
Sbjct: 588 QGHTKVVNCLI--GCGANINHTDQ 609
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 72.0 bits (175), Expect = 6e-13
Identities = 70/244 (28%), Positives = 96/244 (39%), Gaps = 66/244 (27%)
Query: 49 ERYKRFI-----NSRSGWGVPGTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFT 103
ER KR + NSR G TPL AA +G ++ LL +GA+V + D PL
Sbjct: 38 ERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHN 97
Query: 104 AVSHGHLDCVRVLLEAGASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLP 163
A S GH + V +LL GA P N +P+ AA G + + LL HGAE ++
Sbjct: 98 ACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDG 157
Query: 164 VWASNIASCSG---------------------------------------------PLYL 178
A ++A S PL+L
Sbjct: 158 RTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHL 217
Query: 179 AAVYGHLDCFRLLLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNC---EPEYIQLLI 235
AA Y + +LLL HGA D + D+G L + LH+ C E +LL+
Sbjct: 218 AAGYNRVKIVQLLLQHGA--DVHAKDKGDL-----------VPLHNACSYGHYEVTELLV 264
Query: 236 DFGA 239
GA
Sbjct: 265 KHGA 268
Score = 67.0 bits (162), Expect = 2e-11
Identities = 64/229 (27%), Positives = 95/229 (41%), Gaps = 51/229 (22%)
Query: 23 DTEEKQALNQAVYDNDSYTLDQLLRQERYKRFINSRSGWGVPGTPLRLAASYGHLSCLQV 82
++E + L +A D T+ +L + +N R G TPL AA Y +S ++
Sbjct: 489 NSEADRQLLEAAKAGDVETVKKLCTVQS----VNCRDIEGRQSTPLHFAAGYNRVSVVEY 544
Query: 83 LLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNCSPVLTAARDGA 142
LL HGADV + D PL A S+GH + +L++ GA + +P+ AA G
Sbjct: 545 LLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGK 604
Query: 143 VAILQELLDHGAEANVK-------------------------------------AKLPVW 165
I + LL HGA+ K A++
Sbjct: 605 YEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKL 664
Query: 166 AS-NIASC-------SGPLYLAAVYGHLDCFRLLLLHGADPDYNCTDQG 206
+S + +C S PL+LAA Y +L+ LL HGA D N D+G
Sbjct: 665 SSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGA--DVNAQDKG 711
Score = 67.0 bits (162), Expect = 2e-11
Identities = 38/105 (36%), Positives = 55/105 (52%)
Query: 55 INSRSGWGVPGTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVR 114
+N R G TPL LAA Y +L + LL HGADV++ D PL A S+GH+D
Sbjct: 670 VNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAA 729
Query: 115 VLLEAGASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAEANVK 159
+L++ A + +P+ AA+ G + LL HGA+ +K
Sbjct: 730 LLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLK 774
Score = 61.6 bits (148), Expect = 8e-10
Identities = 35/101 (34%), Positives = 51/101 (50%)
Query: 55 INSRSGWGVPGTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVR 114
+N + G TPL LAA Y + +Q+LL HGADV + D PL A S+GH +
Sbjct: 202 VNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTE 261
Query: 115 VLLEAGASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAE 155
+L++ GA +P+ AA V + LL +GA+
Sbjct: 262 LLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGAD 302
Score = 55.5 bits (132), Expect = 6e-08
Identities = 59/203 (29%), Positives = 84/203 (41%), Gaps = 36/203 (17%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL +A+ H ++V++ H A V++LD QT L A GHL R+LL G P
Sbjct: 402 TPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDP-N 460
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHG-AEAN--------------VKAKLPVWASNIA 170
I L + +LQE + G +EA+ VK V + N
Sbjct: 461 IISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCR 520
Query: 171 SCSG----PLYLAAVYGHLDCFRLLLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNC 226
G PL+ AA Y + LL HGA D + D+G L + LH+ C
Sbjct: 521 DIEGRQSTPLHFAAGYNRVSVVEYLLQHGA--DVHAKDKGGL-----------VPLHNAC 567
Query: 227 ---EPEYIQLLIDFGANIYLPSL 246
E +LL+ GA + + L
Sbjct: 568 SYGHYEVAELLVKHGAVVNVADL 590
Score = 46.6 bits (109), Expect = 3e-05
Identities = 23/57 (40%), Positives = 33/57 (57%)
Query: 67 PLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASP 123
PL A SYGH ++L+ HGA V+++D+ TPL A S ++ +LL GA P
Sbjct: 247 PLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADP 303
Score = 46.2 bits (108), Expect = 4e-05
Identities = 39/142 (27%), Positives = 62/142 (43%), Gaps = 6/142 (4%)
Query: 6 ITKIFSLLQPDKEE-EDTDTEEKQALNQAVYDNDSYTLDQLLRQERYKRFINSRSGWGVP 64
+ ++ L PD DT L+ A N+ + LL+ + +N++ G+
Sbjct: 658 LARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQ---HGADVNAQDKGGL- 713
Query: 65 GTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPG 124
PL AASYGH+ +L+ + A V++ D A TPL A G +LL GA P
Sbjct: 714 -IPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPT 772
Query: 125 GSIYNNCSPVLTAARDGAVAIL 146
+P+ + D A+L
Sbjct: 773 LKNQEGQTPLDLVSADDVSALL 794
Score = 35.4 bits (80), Expect = 0.065
Identities = 32/106 (30%), Positives = 51/106 (48%), Gaps = 14/106 (13%)
Query: 97 AQTPLFTAVSHGHLDCV-RVLLEAGASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAE 155
A LF A +G ++ V R++ + + +P+ AA G +++ LL +GA
Sbjct: 24 AARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGA- 82
Query: 156 ANVKAKLPVWASNIASCSG--PLYLAAVYGHLDCFRLLLLHGADPD 199
NV+A+ G PL+ A +GH + LLL HGADP+
Sbjct: 83 -NVQAR---------DDGGLIPLHNACSFGHAEVVNLLLRHGADPN 118
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 70.5 bits (171), Expect = 2e-12
Identities = 44/126 (34%), Positives = 67/126 (53%), Gaps = 9/126 (7%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL +AA +GH+S +++L + GA++D+ +TPL AV G + ++ LL++GA P
Sbjct: 496 TPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDA 555
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+ P+ TAA G I + LL +GA + W PL+LAA GHL
Sbjct: 556 LDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTH-QGWT--------PLHLAAYKGHL 606
Query: 186 DCFRLL 191
+ LL
Sbjct: 607 EIIHLL 612
Score = 60.8 bits (146), Expect = 1e-09
Identities = 47/158 (29%), Positives = 71/158 (44%), Gaps = 17/158 (10%)
Query: 57 SRSGWGVPGTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVL 116
+ GW TPL LAA GHL + +L A++ +L TPL A HG V L
Sbjct: 590 THQGW----TPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSAL 645
Query: 117 LEAGASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPL 176
L+ GA P + + +P+ A + + LL+H A + + K+ W P
Sbjct: 646 LQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVG-WT--------PA 696
Query: 177 YLAAVYGHLDCFRLLLLHGADPD----YNCTDQGLLAR 210
+LAA+ G+ ++L+ GA D +CT L R
Sbjct: 697 HLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALR 734
Score = 57.4 bits (137), Expect = 2e-08
Identities = 40/134 (29%), Positives = 63/134 (47%), Gaps = 9/134 (6%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL +AA +LLAHGAD + +D PL A +G R+LL+ GA
Sbjct: 397 TPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDA 456
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHL 185
+P+ AA++ + + L+ A+ N+ + A PL++AA +GH+
Sbjct: 457 QEREGWTPLHLAAQNNFENVARLLVSRQADPNL---------HEAEGKTPLHVAAYFGHV 507
Query: 186 DCFRLLLLHGADPD 199
+LL GA+ D
Sbjct: 508 SLVKLLTSQGAELD 521
Score = 57.0 bits (136), Expect = 2e-08
Identities = 43/139 (30%), Positives = 64/139 (46%), Gaps = 13/139 (9%)
Query: 58 RSGWGVPGTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLL 117
R GW TPL LAA + ++L++ AD + + + +TPL A GH+ V++L
Sbjct: 459 REGW----TPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLT 514
Query: 118 EAGASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLY 177
GA N +P+ A G V +Q LL GA + + S GPL+
Sbjct: 515 SQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQ---------SGYGPLH 565
Query: 178 LAAVYGHLDCFRLLLLHGA 196
AA G ++LL +GA
Sbjct: 566 TAAARGKYLICKMLLRYGA 584
Score = 55.5 bits (132), Expect = 6e-08
Identities = 47/135 (34%), Positives = 64/135 (47%), Gaps = 11/135 (8%)
Query: 66 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG 125
TPL LA G + +Q LL GA D+LD PL TA + G ++LL GAS
Sbjct: 529 TPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLEL 588
Query: 126 SIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPV-WASNIASCSGPLYLAAVYGH 184
+ +P+ AA G + I+ L + + AN+ A V W PL+LAA +G
Sbjct: 589 PTHQGWTPLHLAAYKGHLEIIHLLAE--SHANMGALGAVNWT--------PLHLAARHGE 638
Query: 185 LDCFRLLLLHGADPD 199
LL GADP+
Sbjct: 639 EAVVSALLQCGADPN 653
Score = 55.1 bits (131), Expect = 8e-08
Identities = 35/100 (35%), Positives = 54/100 (54%), Gaps = 4/100 (4%)
Query: 58 RSGWGVPGTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLL 117
+SG+G PL AA+ G ++LL +GA ++ + TPL A GHL+ + +L
Sbjct: 558 QSGYG----PLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLA 613
Query: 118 EAGASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAEAN 157
E+ A+ G N +P+ AAR G A++ LL GA+ N
Sbjct: 614 ESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPN 653
Score = 54.3 bits (129), Expect = 1e-07
Identities = 42/140 (30%), Positives = 64/140 (45%), Gaps = 13/140 (9%)
Query: 60 GWGVPGTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEA 119
GW PL AA G ++LL HGA VD+ + + TPL A + + R+L+
Sbjct: 428 GWA----PLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSR 483
Query: 120 GASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLA 179
A P +P+ AA G V++++ L GAE + + + + PL+LA
Sbjct: 484 QADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQR---------NLRTPLHLA 534
Query: 180 AVYGHLDCFRLLLLHGADPD 199
G + + LL GA PD
Sbjct: 535 VERGKVRAIQHLLKSGAVPD 554
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,241,694
Number of Sequences: 37866
Number of extensions: 533197
Number of successful extensions: 4219
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 302
Number of HSP's successfully gapped in prelim test: 48
Number of HSP's that attempted gapping in prelim test: 1569
Number of HSP's gapped (non-prelim): 1389
length of query: 309
length of database: 18,247,518
effective HSP length: 102
effective length of query: 207
effective length of database: 14,385,186
effective search space: 2977733502
effective search space used: 2977733502
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.