Guide to the Human Genome
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Search of human proteins with 221316630

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|221316630 coatomer protein complex, subunit beta 1 [Homo
sapiens]
         (953 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|221316632 coatomer protein complex, subunit beta 1 [Homo sapi...  1863   0.0  
gi|221316630 coatomer protein complex, subunit beta 1 [Homo sapi...  1863   0.0  
gi|7705369 coatomer protein complex, subunit beta 1 [Homo sapiens]   1863   0.0  
gi|22027651 adaptor-related protein complex 1 beta 1 subunit iso...    85   3e-16
gi|22027653 adaptor-related protein complex 1 beta 1 subunit iso...    85   3e-16
gi|117553580 adaptor-related protein complex 3, delta 1 subunit ...    83   1e-15
gi|71773106 adaptor-related protein complex 2, beta 1 subunit is...    79   2e-14
gi|4557469 adaptor-related protein complex 2, beta 1 subunit iso...    79   2e-14
gi|34482047 adaptor-related protein complex 3, beta 2 subunit [H...    69   3e-11
gi|32484979 adaptor-related protein complex 3, beta 1 subunit [H...    67   6e-11
gi|37675283 adaptor-related protein complex 4, epsilon 1 subunit...    60   7e-09
gi|71773010 adaptor-related protein complex 1, gamma 1 subunit i...    55   3e-07
gi|71772942 adaptor-related protein complex 1, gamma 1 subunit i...    54   7e-07
gi|4503843 adaptor-related protein complex 1, gamma 2 subunit [H...    50   1e-05
gi|166197671 adaptor-related protein complex 4, beta 1 subunit [...    44   7e-04
gi|109134349 coatomer protein complex, subunit gamma 2 [Homo sap...    37   0.067
gi|11559929 coatomer protein complex, subunit gamma 1 [Homo sapi...    36   0.15 
gi|151301127 dynein, axonemal, heavy chain 7 [Homo sapiens]            35   0.44 
gi|51093836 hypothetical protein LOC126859 isoform 1 [Homo sapiens]    34   0.57 
gi|95147555 microtubule-associated protein 1A [Homo sapiens]           34   0.74 
gi|64085252 hypothetical protein LOC145508 [Homo sapiens]              34   0.74 
gi|239744625 PREDICTED: hypothetical protein XP_002343208 [Homo ...    33   0.97 
gi|127138957 zinc finger protein 537 [Homo sapiens]                    33   0.97 
gi|109659847 filamin A interacting protein 1-like isoform 3 [Hom...    33   1.3  
gi|109659849 filamin A interacting protein 1-like isoform 2 [Hom...    33   1.3  
gi|109659845 filamin A interacting protein 1-like isoform 1 [Hom...    33   1.3  
gi|71061468 centromere protein E [Homo sapiens]                        33   1.3  
gi|19923599 calmin [Homo sapiens]                                      33   1.3  
gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 ...    33   1.7  
gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [...    33   1.7  

>gi|221316632 coatomer protein complex, subunit beta 1 [Homo
           sapiens]
          Length = 953

 Score = 1863 bits (4827), Expect = 0.0
 Identities = 953/953 (100%), Positives = 953/953 (100%)

Query: 1   MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLM 60
           MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLM
Sbjct: 1   MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLM 60

Query: 61  TIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGST 120
           TIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGST
Sbjct: 61  TIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGST 120

Query: 121 LRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPELIHDF 180
           LRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPELIHDF
Sbjct: 121 LRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPELIHDF 180

Query: 181 LVNEKDASCKRNAFMMLIHADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKVCHANPS 240
           LVNEKDASCKRNAFMMLIHADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKVCHANPS
Sbjct: 181 LVNEKDASCKRNAFMMLIHADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKVCHANPS 240

Query: 241 ERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLI 300
           ERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLI
Sbjct: 241 ERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLI 300

Query: 301 VLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELVIVL 360
           VLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELVIVL
Sbjct: 301 VLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELVIVL 360

Query: 361 KKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLSDNNEAAAADV 420
           KKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLSDNNEAAAADV
Sbjct: 361 KKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLSDNNEAAAADV 420

Query: 421 LEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYCSTKEDIQSVMTEIR 480
           LEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYCSTKEDIQSVMTEIR
Sbjct: 421 LEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYCSTKEDIQSVMTEIR 480

Query: 481 RSLGEIPIVESEIKKEAGELKPEEEITVGPVQKLVTEMGTYATQSALSSSRPTKKEEDRP 540
           RSLGEIPIVESEIKKEAGELKPEEEITVGPVQKLVTEMGTYATQSALSSSRPTKKEEDRP
Sbjct: 481 RSLGEIPIVESEIKKEAGELKPEEEITVGPVQKLVTEMGTYATQSALSSSRPTKKEEDRP 540

Query: 541 PLRGFLLDGDFFVAASLATTLTKIALRYVALVQEKKKQNSFVAEAMLLMATILHLGKSSL 600
           PLRGFLLDGDFFVAASLATTLTKIALRYVALVQEKKKQNSFVAEAMLLMATILHLGKSSL
Sbjct: 541 PLRGFLLDGDFFVAASLATTLTKIALRYVALVQEKKKQNSFVAEAMLLMATILHLGKSSL 600

Query: 601 PKKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRQSLSHMLSAKLEEEKLSQKKESEK 660
           PKKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRQSLSHMLSAKLEEEKLSQKKESEK
Sbjct: 601 PKKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRQSLSHMLSAKLEEEKLSQKKESEK 660

Query: 661 RNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSLLAAMGNTQRKEAADPLASKLNKVTQLT 720
           RNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSLLAAMGNTQRKEAADPLASKLNKVTQLT
Sbjct: 661 RNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSLLAAMGNTQRKEAADPLASKLNKVTQLT 720

Query: 721 GFSDPVYAEAYVHVNQYDIVLDVLVVNQTSDTLQNCTLELATLGDLKLVEKPSPLTLAPH 780
           GFSDPVYAEAYVHVNQYDIVLDVLVVNQTSDTLQNCTLELATLGDLKLVEKPSPLTLAPH
Sbjct: 721 GFSDPVYAEAYVHVNQYDIVLDVLVVNQTSDTLQNCTLELATLGDLKLVEKPSPLTLAPH 780

Query: 781 DFANIKANVKVASTENGIIFGNIVYDVSGAASDRNCVVLSDIHIDIMDYIQPATCTDAEF 840
           DFANIKANVKVASTENGIIFGNIVYDVSGAASDRNCVVLSDIHIDIMDYIQPATCTDAEF
Sbjct: 781 DFANIKANVKVASTENGIIFGNIVYDVSGAASDRNCVVLSDIHIDIMDYIQPATCTDAEF 840

Query: 841 RQMWAEFEWENKVTVNTNMVDLNDYLQHILKSTNMKCLTPEKALSGYCGFMAANLYARSI 900
           RQMWAEFEWENKVTVNTNMVDLNDYLQHILKSTNMKCLTPEKALSGYCGFMAANLYARSI
Sbjct: 841 RQMWAEFEWENKVTVNTNMVDLNDYLQHILKSTNMKCLTPEKALSGYCGFMAANLYARSI 900

Query: 901 FGEDALANVSIEKPIHQGPDAAVTGHIRIRAKSQGMALSLGDKINLSQKKTSI 953
           FGEDALANVSIEKPIHQGPDAAVTGHIRIRAKSQGMALSLGDKINLSQKKTSI
Sbjct: 901 FGEDALANVSIEKPIHQGPDAAVTGHIRIRAKSQGMALSLGDKINLSQKKTSI 953


>gi|221316630 coatomer protein complex, subunit beta 1 [Homo
           sapiens]
          Length = 953

 Score = 1863 bits (4827), Expect = 0.0
 Identities = 953/953 (100%), Positives = 953/953 (100%)

Query: 1   MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLM 60
           MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLM
Sbjct: 1   MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLM 60

Query: 61  TIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGST 120
           TIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGST
Sbjct: 61  TIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGST 120

Query: 121 LRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPELIHDF 180
           LRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPELIHDF
Sbjct: 121 LRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPELIHDF 180

Query: 181 LVNEKDASCKRNAFMMLIHADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKVCHANPS 240
           LVNEKDASCKRNAFMMLIHADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKVCHANPS
Sbjct: 181 LVNEKDASCKRNAFMMLIHADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKVCHANPS 240

Query: 241 ERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLI 300
           ERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLI
Sbjct: 241 ERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLI 300

Query: 301 VLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELVIVL 360
           VLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELVIVL
Sbjct: 301 VLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELVIVL 360

Query: 361 KKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLSDNNEAAAADV 420
           KKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLSDNNEAAAADV
Sbjct: 361 KKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLSDNNEAAAADV 420

Query: 421 LEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYCSTKEDIQSVMTEIR 480
           LEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYCSTKEDIQSVMTEIR
Sbjct: 421 LEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYCSTKEDIQSVMTEIR 480

Query: 481 RSLGEIPIVESEIKKEAGELKPEEEITVGPVQKLVTEMGTYATQSALSSSRPTKKEEDRP 540
           RSLGEIPIVESEIKKEAGELKPEEEITVGPVQKLVTEMGTYATQSALSSSRPTKKEEDRP
Sbjct: 481 RSLGEIPIVESEIKKEAGELKPEEEITVGPVQKLVTEMGTYATQSALSSSRPTKKEEDRP 540

Query: 541 PLRGFLLDGDFFVAASLATTLTKIALRYVALVQEKKKQNSFVAEAMLLMATILHLGKSSL 600
           PLRGFLLDGDFFVAASLATTLTKIALRYVALVQEKKKQNSFVAEAMLLMATILHLGKSSL
Sbjct: 541 PLRGFLLDGDFFVAASLATTLTKIALRYVALVQEKKKQNSFVAEAMLLMATILHLGKSSL 600

Query: 601 PKKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRQSLSHMLSAKLEEEKLSQKKESEK 660
           PKKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRQSLSHMLSAKLEEEKLSQKKESEK
Sbjct: 601 PKKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRQSLSHMLSAKLEEEKLSQKKESEK 660

Query: 661 RNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSLLAAMGNTQRKEAADPLASKLNKVTQLT 720
           RNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSLLAAMGNTQRKEAADPLASKLNKVTQLT
Sbjct: 661 RNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSLLAAMGNTQRKEAADPLASKLNKVTQLT 720

Query: 721 GFSDPVYAEAYVHVNQYDIVLDVLVVNQTSDTLQNCTLELATLGDLKLVEKPSPLTLAPH 780
           GFSDPVYAEAYVHVNQYDIVLDVLVVNQTSDTLQNCTLELATLGDLKLVEKPSPLTLAPH
Sbjct: 721 GFSDPVYAEAYVHVNQYDIVLDVLVVNQTSDTLQNCTLELATLGDLKLVEKPSPLTLAPH 780

Query: 781 DFANIKANVKVASTENGIIFGNIVYDVSGAASDRNCVVLSDIHIDIMDYIQPATCTDAEF 840
           DFANIKANVKVASTENGIIFGNIVYDVSGAASDRNCVVLSDIHIDIMDYIQPATCTDAEF
Sbjct: 781 DFANIKANVKVASTENGIIFGNIVYDVSGAASDRNCVVLSDIHIDIMDYIQPATCTDAEF 840

Query: 841 RQMWAEFEWENKVTVNTNMVDLNDYLQHILKSTNMKCLTPEKALSGYCGFMAANLYARSI 900
           RQMWAEFEWENKVTVNTNMVDLNDYLQHILKSTNMKCLTPEKALSGYCGFMAANLYARSI
Sbjct: 841 RQMWAEFEWENKVTVNTNMVDLNDYLQHILKSTNMKCLTPEKALSGYCGFMAANLYARSI 900

Query: 901 FGEDALANVSIEKPIHQGPDAAVTGHIRIRAKSQGMALSLGDKINLSQKKTSI 953
           FGEDALANVSIEKPIHQGPDAAVTGHIRIRAKSQGMALSLGDKINLSQKKTSI
Sbjct: 901 FGEDALANVSIEKPIHQGPDAAVTGHIRIRAKSQGMALSLGDKINLSQKKTSI 953


>gi|7705369 coatomer protein complex, subunit beta 1 [Homo sapiens]
          Length = 953

 Score = 1863 bits (4827), Expect = 0.0
 Identities = 953/953 (100%), Positives = 953/953 (100%)

Query: 1   MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLM 60
           MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLM
Sbjct: 1   MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLM 60

Query: 61  TIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGST 120
           TIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGST
Sbjct: 61  TIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGST 120

Query: 121 LRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPELIHDF 180
           LRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPELIHDF
Sbjct: 121 LRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPELIHDF 180

Query: 181 LVNEKDASCKRNAFMMLIHADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKVCHANPS 240
           LVNEKDASCKRNAFMMLIHADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKVCHANPS
Sbjct: 181 LVNEKDASCKRNAFMMLIHADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKVCHANPS 240

Query: 241 ERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLI 300
           ERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLI
Sbjct: 241 ERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLI 300

Query: 301 VLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELVIVL 360
           VLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELVIVL
Sbjct: 301 VLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELVIVL 360

Query: 361 KKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLSDNNEAAAADV 420
           KKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLSDNNEAAAADV
Sbjct: 361 KKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLSDNNEAAAADV 420

Query: 421 LEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYCSTKEDIQSVMTEIR 480
           LEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYCSTKEDIQSVMTEIR
Sbjct: 421 LEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYCSTKEDIQSVMTEIR 480

Query: 481 RSLGEIPIVESEIKKEAGELKPEEEITVGPVQKLVTEMGTYATQSALSSSRPTKKEEDRP 540
           RSLGEIPIVESEIKKEAGELKPEEEITVGPVQKLVTEMGTYATQSALSSSRPTKKEEDRP
Sbjct: 481 RSLGEIPIVESEIKKEAGELKPEEEITVGPVQKLVTEMGTYATQSALSSSRPTKKEEDRP 540

Query: 541 PLRGFLLDGDFFVAASLATTLTKIALRYVALVQEKKKQNSFVAEAMLLMATILHLGKSSL 600
           PLRGFLLDGDFFVAASLATTLTKIALRYVALVQEKKKQNSFVAEAMLLMATILHLGKSSL
Sbjct: 541 PLRGFLLDGDFFVAASLATTLTKIALRYVALVQEKKKQNSFVAEAMLLMATILHLGKSSL 600

Query: 601 PKKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRQSLSHMLSAKLEEEKLSQKKESEK 660
           PKKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRQSLSHMLSAKLEEEKLSQKKESEK
Sbjct: 601 PKKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRQSLSHMLSAKLEEEKLSQKKESEK 660

Query: 661 RNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSLLAAMGNTQRKEAADPLASKLNKVTQLT 720
           RNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSLLAAMGNTQRKEAADPLASKLNKVTQLT
Sbjct: 661 RNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSLLAAMGNTQRKEAADPLASKLNKVTQLT 720

Query: 721 GFSDPVYAEAYVHVNQYDIVLDVLVVNQTSDTLQNCTLELATLGDLKLVEKPSPLTLAPH 780
           GFSDPVYAEAYVHVNQYDIVLDVLVVNQTSDTLQNCTLELATLGDLKLVEKPSPLTLAPH
Sbjct: 721 GFSDPVYAEAYVHVNQYDIVLDVLVVNQTSDTLQNCTLELATLGDLKLVEKPSPLTLAPH 780

Query: 781 DFANIKANVKVASTENGIIFGNIVYDVSGAASDRNCVVLSDIHIDIMDYIQPATCTDAEF 840
           DFANIKANVKVASTENGIIFGNIVYDVSGAASDRNCVVLSDIHIDIMDYIQPATCTDAEF
Sbjct: 781 DFANIKANVKVASTENGIIFGNIVYDVSGAASDRNCVVLSDIHIDIMDYIQPATCTDAEF 840

Query: 841 RQMWAEFEWENKVTVNTNMVDLNDYLQHILKSTNMKCLTPEKALSGYCGFMAANLYARSI 900
           RQMWAEFEWENKVTVNTNMVDLNDYLQHILKSTNMKCLTPEKALSGYCGFMAANLYARSI
Sbjct: 841 RQMWAEFEWENKVTVNTNMVDLNDYLQHILKSTNMKCLTPEKALSGYCGFMAANLYARSI 900

Query: 901 FGEDALANVSIEKPIHQGPDAAVTGHIRIRAKSQGMALSLGDKINLSQKKTSI 953
           FGEDALANVSIEKPIHQGPDAAVTGHIRIRAKSQGMALSLGDKINLSQKKTSI
Sbjct: 901 FGEDALANVSIEKPIHQGPDAAVTGHIRIRAKSQGMALSLGDKINLSQKKTSI 953


>gi|22027651 adaptor-related protein complex 1 beta 1 subunit
           isoform a [Homo sapiens]
          Length = 949

 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 120/620 (19%), Positives = 250/620 (40%), Gaps = 101/620 (16%)

Query: 26  LKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLMTIIRFVLPLQDHTIKKLLLVFWEIV 85
           LK +L     + K EA+KKVI  +  G+ +  L   ++   +   +  +KKL+ ++    
Sbjct: 18  LKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVN-CMQTDNLELKKLVYLYLMNY 76

Query: 86  PKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLE 145
            K+ PD       I+  + + KD + PN  IR   +R +  ++  ++ E L   +R CL+
Sbjct: 77  AKSQPD-----MAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLK 131

Query: 146 HRHSYVRRNAVLAIYTIYRNFEHLIPDAP--ELIHDFLVNEKDASCKRNAFMMLIHADQD 203
               YVR+ A + +  ++     L+ D    + + D L+++ +     NA   L    + 
Sbjct: 132 DEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKD-LISDSNPMVVANAVAALSEIAES 190

Query: 204 -----------RALDYLSTCIDQVQTFGDIL----------------QLVIVELIYKVCH 236
                      ++++ L T +++   +G I                 Q +   +  ++ H
Sbjct: 191 HPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSICERVTPRLSH 250

Query: 237 ANPSERARFIRCIYNLLQSSSPAVKY------EAAGTLVTLSSAPTAIKAAAQCYIDLII 290
           AN +     ++ +   ++  S  + Y      + A  LVTL SA   ++  A   I+LI+
Sbjct: 251 ANSAVVLSAVKVLMKFMEMLSKDLDYYGTLLKKLAPPLVTLLSAEPELQYVALRNINLIV 310

Query: 291 KESDNNVKLIVLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSS 350
           ++    +K               HE       M +  V     + V+ + L + + L S 
Sbjct: 311 QKRPEILK---------------HE-------MKVFFVKYNDPIYVKLEKLDIMIRLASQ 348

Query: 351 RNVEELVIVLKKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLS 410
            N+ +++  LK+   +        D D  R+  VR +  C+++    A   +  L++ + 
Sbjct: 349 ANIAQVLAELKEYATEV-------DVDFVRK-AVRAIGRCAIKVEQSAERCVSTLLDLIQ 400

Query: 411 DNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYCSTKE 470
                   + +  +++  +++ N    ++  + E   ++   +     +WI+GEY    +
Sbjct: 401 TKVNYVVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERID 460

Query: 471 DIQSVMTEIRRSL-GEIPIVESEIKKEAGEL---KPEEEITVGPVQKLVTEMGTYATQSA 526
           +   ++         E   V+ ++     +L   KP E       Q+LV ++ + ATQ  
Sbjct: 461 NADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTE------TQELVQQVLSLATQ-- 512

Query: 527 LSSSRPTKKEEDRPPLRGFLLDGDFFVAASLATTLTKIALRYVALVQEKK-KQNSFVAEA 585
                    + D P LR    D  +     L+T    +A + V L ++    + + + E 
Sbjct: 513 ---------DSDNPDLR----DRGYIYWRLLST--DPVAAKEVVLAEKPLISEETDLIEP 557

Query: 586 MLLMATILHLGK-SSLPKKP 604
            LL   I ++G  +S+  KP
Sbjct: 558 TLLDELICYIGTLASVYHKP 577


>gi|22027653 adaptor-related protein complex 1 beta 1 subunit
           isoform b [Homo sapiens]
          Length = 942

 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 120/620 (19%), Positives = 250/620 (40%), Gaps = 101/620 (16%)

Query: 26  LKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLMTIIRFVLPLQDHTIKKLLLVFWEIV 85
           LK +L     + K EA+KKVI  +  G+ +  L   ++   +   +  +KKL+ ++    
Sbjct: 18  LKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVN-CMQTDNLELKKLVYLYLMNY 76

Query: 86  PKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLE 145
            K+ PD       I+  + + KD + PN  IR   +R +  ++  ++ E L   +R CL+
Sbjct: 77  AKSQPD-----MAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLK 131

Query: 146 HRHSYVRRNAVLAIYTIYRNFEHLIPDAP--ELIHDFLVNEKDASCKRNAFMMLIHADQD 203
               YVR+ A + +  ++     L+ D    + + D L+++ +     NA   L    + 
Sbjct: 132 DEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKD-LISDSNPMVVANAVAALSEIAES 190

Query: 204 -----------RALDYLSTCIDQVQTFGDIL----------------QLVIVELIYKVCH 236
                      ++++ L T +++   +G I                 Q +   +  ++ H
Sbjct: 191 HPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSICERVTPRLSH 250

Query: 237 ANPSERARFIRCIYNLLQSSSPAVKY------EAAGTLVTLSSAPTAIKAAAQCYIDLII 290
           AN +     ++ +   ++  S  + Y      + A  LVTL SA   ++  A   I+LI+
Sbjct: 251 ANSAVVLSAVKVLMKFMEMLSKDLDYYGTLLKKLAPPLVTLLSAEPELQYVALRNINLIV 310

Query: 291 KESDNNVKLIVLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSS 350
           ++    +K               HE       M +  V     + V+ + L + + L S 
Sbjct: 311 QKRPEILK---------------HE-------MKVFFVKYNDPIYVKLEKLDIMIRLASQ 348

Query: 351 RNVEELVIVLKKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLS 410
            N+ +++  LK+   +        D D  R+  VR +  C+++    A   +  L++ + 
Sbjct: 349 ANIAQVLAELKEYATEV-------DVDFVRK-AVRAIGRCAIKVEQSAERCVSTLLDLIQ 400

Query: 411 DNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYCSTKE 470
                   + +  +++  +++ N    ++  + E   ++   +     +WI+GEY    +
Sbjct: 401 TKVNYVVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERID 460

Query: 471 DIQSVMTEIRRSL-GEIPIVESEIKKEAGEL---KPEEEITVGPVQKLVTEMGTYATQSA 526
           +   ++         E   V+ ++     +L   KP E       Q+LV ++ + ATQ  
Sbjct: 461 NADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTE------TQELVQQVLSLATQ-- 512

Query: 527 LSSSRPTKKEEDRPPLRGFLLDGDFFVAASLATTLTKIALRYVALVQEKK-KQNSFVAEA 585
                    + D P LR    D  +     L+T    +A + V L ++    + + + E 
Sbjct: 513 ---------DSDNPDLR----DRGYIYWRLLST--DPVAAKEVVLAEKPLISEETDLIEP 557

Query: 586 MLLMATILHLGK-SSLPKKP 604
            LL   I ++G  +S+  KP
Sbjct: 558 TLLDELICYIGTLASVYHKP 577


>gi|117553580 adaptor-related protein complex 3, delta 1 subunit
           isoform 2 [Homo sapiens]
          Length = 1153

 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 121/534 (22%), Positives = 226/534 (42%), Gaps = 65/534 (12%)

Query: 26  LKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLMTIIRFVLPLQDHTIKKLLLVFWEIV 85
           +K +L++ ++  K  A+ K+  + + G  +      II  V+     T K++  +     
Sbjct: 43  IKQELKQDNIAVKANAVCKLTYLQMLGYDISWAAFNIIE-VMSASKFTFKRIGYL----- 96

Query: 86  PKTTPDGRLLHE----MILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIR 141
                  +  HE    ++L  +  RKDL  P+++  G  L  L      +L   L   I 
Sbjct: 97  ----AASQSFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGLSCFVTPDLARDLANDIM 152

Query: 142 ACLEHRHSYVRRNAVLAIYTIYRNF-EHLIPDAPELIHDFLVNEKDASCKRNAFMMLIHA 200
             + H   Y+R+ AVL +Y ++  + E L P  P L     + + D   +  A  ++   
Sbjct: 153 TLMSHTKPYIRKKAVLIMYKVFLKYPESLRPAFPRLKEK--LEDPDPGVQSAAVNVICEL 210

Query: 201 DQDRALDYLSTC----IDQVQTFGDILQLVIVELIYKVCHANPSERARFIRCIYNLLQSS 256
            +    +YLS           +  + + + I++L   +    P    + I  + NL+ S+
Sbjct: 211 ARRNPKNYLSLAPLFFKLMTSSTNNWVLIKIIKLFGALTPLEPRLGKKLIEPLTNLIHST 270

Query: 257 SP-AVKYEAAGT----LVTLSSAPTAIKAAAQCYID---LIIKESDNNVKLIVLDRLIE- 307
           S  ++ YE   T    L++LSS      A+ Q  +    ++I++SD N+K + L  + + 
Sbjct: 271 SAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKI 330

Query: 308 LKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELVIVLKKEVIKT 367
           LK HP   +  +DL   IL+ L   D  +R + L L   +VS +N+ E+V  L   V K 
Sbjct: 331 LKTHPKSVQSHKDL---ILQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKA 387

Query: 368 NNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAAN---VIPVLMEFL----SDNNEAAAADV 420
                 E T    +LL + +  CS        N    I +L+E      + +    AA +
Sbjct: 388 ------EGTTYRDELLTKIIDICSQSNYQYITNFEWYISILVELTRLEGTRHGHLIAAQM 441

Query: 421 LEFV--REAIQRFDNLRMLIVEKMLEVFHAIKS-------VKIYRGALWILGEYCS-TKE 470
           L+     +AI++F   +M     +L+  H + S        ++   A WI GE+    +E
Sbjct: 442 LDVAIRVKAIRKFAVSQM---SALLDSAHLLASSTQRNGICEVLYAAAWICGEFSEHLQE 498

Query: 471 DIQSVMTEIRRSLGEIP------IVESEIKKEAGELKPEEEITVGPVQKLVTEM 518
              ++   +R  +  +P       V++ +K  A  L+ +E+       + VT++
Sbjct: 499 PHHTLEAMLRPRVTTLPGHIQAVYVQNVVKLYASILQQKEQAGEAEGAQAVTQL 552


>gi|71773106 adaptor-related protein complex 2, beta 1 subunit
           isoform a [Homo sapiens]
          Length = 951

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 122/622 (19%), Positives = 244/622 (39%), Gaps = 105/622 (16%)

Query: 26  LKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLMTIIRFVLPLQDHTIKKLLLVFWEIV 85
           LK +L     + + EA+KKVI  +  G+ +  L   ++   +   +  +KKL+ ++    
Sbjct: 18  LKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVN-CMQTDNLELKKLVYLYLMNY 76

Query: 86  PKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLE 145
            K+ PD       I+  +++ KD + PN  IR   +R +  ++  ++ E L   +R CL+
Sbjct: 77  AKSQPD-----MAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLK 131

Query: 146 HRHSYVRRNAVLAIYTIYRNFEHLIPDAPEL--IHDFLVNEKDASCKRNAFMMLIHADQD 203
               YVR+ A + +  ++     ++ D   L  + D L+ + +     NA   L    + 
Sbjct: 132 DEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRD-LIADSNPMVVANAVAALSEISES 190

Query: 204 -----------RALDYLSTCIDQVQTFGDIL----------------QLVIVELIYKVCH 236
                      + ++ L T +++   +G I                 Q +   +  ++ H
Sbjct: 191 HPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSICERVTPRLSH 250

Query: 237 ANPSERARFIRCIYNLLQSSSPAVKY------EAAGTLVTLSSAPTAIKAAAQCYIDLII 290
           AN +     ++ +   L+       Y      + A  LVTL S    ++     Y+ L  
Sbjct: 251 ANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQ-----YVAL-- 303

Query: 291 KESDNNVKLIVLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSS 350
                N+ LIV  R   LK+            + +  V     + V+ + L + + L S 
Sbjct: 304 ----RNINLIVQKRPEILKQE-----------IKVFFVKYNDPIYVKLEKLDIMIRLASQ 348

Query: 351 RNVEELVIVLKKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLS 410
            N+ +++  LK+   +        D D  R+  VR +  C+++    A   +  L++ + 
Sbjct: 349 ANIAQVLAELKEYATEV-------DVDFVRK-AVRAIGRCAIKVEQSAERCVSTLLDLIQ 400

Query: 411 DNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYC---- 466
                   + +  +R+  +++ N    I+  + E   ++         +WI+GEY     
Sbjct: 401 TKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERID 460

Query: 467 STKEDIQSVMTEIRRSLGEIPIVESEIKKEAGELKPEEEITVGPVQKLVTEMGTYATQSA 526
           +  E ++S +        ++ +       +    KP E       Q+LV ++ + ATQ  
Sbjct: 461 NADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSE------TQELVQQVLSLATQ-- 512

Query: 527 LSSSRPTKKEEDRPPLRGFLLDGDFFVAASLAT---TLTKIALRYVALVQEKKKQNSFVA 583
                    + D P LR    D  +     L+T   T  ++ L    L+ E+    + + 
Sbjct: 513 ---------DSDNPDLR----DRGYIYWRLLSTDPVTAKEVVLSEKPLISEE----TDLI 555

Query: 584 EAMLLMATILHLGK-SSLPKKP 604
           E  LL   I H+G  +S+  KP
Sbjct: 556 EPTLLDELICHIGSLASVYHKP 577


>gi|4557469 adaptor-related protein complex 2, beta 1 subunit
           isoform b [Homo sapiens]
          Length = 937

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 122/622 (19%), Positives = 244/622 (39%), Gaps = 105/622 (16%)

Query: 26  LKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLMTIIRFVLPLQDHTIKKLLLVFWEIV 85
           LK +L     + + EA+KKVI  +  G+ +  L   ++   +   +  +KKL+ ++    
Sbjct: 18  LKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVN-CMQTDNLELKKLVYLYLMNY 76

Query: 86  PKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLE 145
            K+ PD       I+  +++ KD + PN  IR   +R +  ++  ++ E L   +R CL+
Sbjct: 77  AKSQPD-----MAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLK 131

Query: 146 HRHSYVRRNAVLAIYTIYRNFEHLIPDAPEL--IHDFLVNEKDASCKRNAFMMLIHADQD 203
               YVR+ A + +  ++     ++ D   L  + D L+ + +     NA   L    + 
Sbjct: 132 DEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRD-LIADSNPMVVANAVAALSEISES 190

Query: 204 -----------RALDYLSTCIDQVQTFGDIL----------------QLVIVELIYKVCH 236
                      + ++ L T +++   +G I                 Q +   +  ++ H
Sbjct: 191 HPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSICERVTPRLSH 250

Query: 237 ANPSERARFIRCIYNLLQSSSPAVKY------EAAGTLVTLSSAPTAIKAAAQCYIDLII 290
           AN +     ++ +   L+       Y      + A  LVTL S    ++     Y+ L  
Sbjct: 251 ANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQ-----YVAL-- 303

Query: 291 KESDNNVKLIVLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSS 350
                N+ LIV  R   LK+            + +  V     + V+ + L + + L S 
Sbjct: 304 ----RNINLIVQKRPEILKQE-----------IKVFFVKYNDPIYVKLEKLDIMIRLASQ 348

Query: 351 RNVEELVIVLKKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLS 410
            N+ +++  LK+   +        D D  R+  VR +  C+++    A   +  L++ + 
Sbjct: 349 ANIAQVLAELKEYATEV-------DVDFVRK-AVRAIGRCAIKVEQSAERCVSTLLDLIQ 400

Query: 411 DNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYC---- 466
                   + +  +R+  +++ N    I+  + E   ++         +WI+GEY     
Sbjct: 401 TKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERID 460

Query: 467 STKEDIQSVMTEIRRSLGEIPIVESEIKKEAGELKPEEEITVGPVQKLVTEMGTYATQSA 526
           +  E ++S +        ++ +       +    KP E       Q+LV ++ + ATQ  
Sbjct: 461 NADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSE------TQELVQQVLSLATQ-- 512

Query: 527 LSSSRPTKKEEDRPPLRGFLLDGDFFVAASLAT---TLTKIALRYVALVQEKKKQNSFVA 583
                    + D P LR    D  +     L+T   T  ++ L    L+ E+    + + 
Sbjct: 513 ---------DSDNPDLR----DRGYIYWRLLSTDPVTAKEVVLSEKPLISEE----TDLI 555

Query: 584 EAMLLMATILHLGK-SSLPKKP 604
           E  LL   I H+G  +S+  KP
Sbjct: 556 EPTLLDELICHIGSLASVYHKP 577


>gi|34482047 adaptor-related protein complex 3, beta 2 subunit [Homo
           sapiens]
          Length = 1082

 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 101/548 (18%), Positives = 210/548 (38%), Gaps = 84/548 (15%)

Query: 26  LKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLMTIIRFVLPLQDHTIKKLLLVFWEIV 85
           LK  L+      K EA+K+++ MI  G+    L   +++ V   ++  +KKL+ V+    
Sbjct: 42  LKEMLDTNKDSLKLEAMKRIVAMIARGKNASDLFPAVVKNVA-CKNIEVKKLVYVYLVRY 100

Query: 86  PKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLE 145
            +   D  LL         +++ L+ PN+ IR S LR L  ++   ++  +M AI+    
Sbjct: 101 AEEQQDLALLS-----ISTFQRGLKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAAS 155

Query: 146 HRHSYVRRNAVLAIYTIY-----------RNFEHLIPDAPELIHDFLVNEKDASCKRNAF 194
               YVR+ A  AI  +Y              E L+ D   L+   +V   +  C     
Sbjct: 156 DMSPYVRKTAAHAIPKLYSLDSDQKDQLIEVIEKLLADKTTLVAGSVVMAFEEVCPER-- 213

Query: 195 MMLIHADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKVCHANPSERARFI-----RCI 249
           + LIH +  +    L   +  V+ +G ++ + ++    +    +P++    +     +  
Sbjct: 214 IDLIHKNYRK----LCNLLIDVEEWGQVVIISMLTRYARTQFLSPTQNESLLEENAEKAF 269

Query: 250 YNLLQSSSPAVKYEAAGTLVTLSSAP-----------------------TAIKAAAQCYI 286
           Y   +  +     E        S  P                         + A AQ Y 
Sbjct: 270 YGSEEDEAKGAGSEETAAAAAPSRKPYVMDPDHRLLLRNTKPLLQSRSAAVVMAVAQLYF 329

Query: 287 DLIIK--------------ESDNNVKLIVLDRL--IELKEHPAHERVLQDLVMDILRVLS 330
            L  K               S + V+ +VL  +  + +K     E  L+        + S
Sbjct: 330 HLAPKAEVGVIAKALVRLLRSHSEVQYVVLQNVATMSIKRRGMFEPYLKSFY-----IRS 384

Query: 331 TPDLEVRKKTLQLALDLVSSRNVEELVIVLKKEVIKTNNVSEHEDTDKYRQLLVRTLHSC 390
           T   +++   L++  +L +  N+  ++        +T   S  +D   +    ++ +  C
Sbjct: 385 TDPTQIKILKLEVLTNLANETNIPTVL-----REFQTYIRSMDKD---FVAATIQAIGRC 436

Query: 391 SVRFPDMAANVIPVLMEFLSDNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIK 450
           +     +    +  L++ LS+ +E   A+ +  +++ +Q        I++ + ++   I+
Sbjct: 437 ATNIGRVRDTCLNGLVQLLSNRDELVVAESVVVIKKLLQMQPAQHGEIIKHLAKLTDNIQ 496

Query: 451 SVKIYRGALWILGEYCSTKEDIQSVMTEIRRSLGEIPIVESEI-KKEAGELKPEEEITVG 509
                   LW++GEYC   E +  +  ++ R + +    E +I K +   L  +  +T  
Sbjct: 497 VPMARASILWLIGEYC---EHVPRIAPDVLRKMAKSFTAEEDIVKLQVINLAAKLYLTNS 553

Query: 510 PVQKLVTE 517
              KL+T+
Sbjct: 554 KQTKLLTQ 561


>gi|32484979 adaptor-related protein complex 3, beta 1 subunit [Homo
           sapiens]
          Length = 1094

 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 102/518 (19%), Positives = 203/518 (39%), Gaps = 79/518 (15%)

Query: 26  LKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLMTIIRFVLPLQDHTIKKLLLVFWEIV 85
           LK  LE     +K +A+K+++ MI  G+    L   +++ V   ++  IKKL+ V+    
Sbjct: 47  LKQMLESNKDSAKLDAMKRIVGMIAKGKNASELFPAVVKNVAS-KNIEIKKLVYVYLVRY 105

Query: 86  PKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLE 145
            +   D  LL         +++ L+ PN+ IR S LR L  ++   ++  +M AI+    
Sbjct: 106 AEEQQDLALLS-----ISTFQRALKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEASA 160

Query: 146 HRHSYVRRNAVLAIYTIYRNFEHLIPDAPELIHDF---LVNEKDASCKRNAFMMLIHADQ 202
               YVR+NA  AI  +Y     L P+  E++ +    L+ +K      +  M       
Sbjct: 161 DLSPYVRKNAAHAIQKLY----SLDPEQKEMLIEVIEKLLKDKSTLVAGSVVMAFEEVCP 216

Query: 203 DRA----LDYLSTC--IDQVQTFGDILQLVIVELIYKVCHA------------------- 237
           DR      +Y   C  +  V+ +G   Q+VI+ ++ +                       
Sbjct: 217 DRIDLIHKNYRKLCNLLVDVEEWG---QVVIIHMLTRYARTQFVSPWKEGDELEDNGKNF 273

Query: 238 --------------------NPSERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTA 277
                               +P  R   IR    LLQS + AV   A   L    S  + 
Sbjct: 274 YESDDDQKEKTDKKKKPYTMDPDHRL-LIRNTKPLLQSRNAAV-VMAVAQLYWHISPKSE 331

Query: 278 IKAAAQCYIDLIIKESDNNVKLIVLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVR 337
               ++  + L+   S+  V+ IVL  +  +       + + +  +    V ST    ++
Sbjct: 332 AGIISKSLVRLL--RSNREVQYIVLQNIATMS---IQRKGMFEPYLKSFYVRSTDPTMIK 386

Query: 338 KKTLQLALDLVSSRNVEELVIVLKKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDM 397
              L++  +L +  N+  L+   +  V             ++    ++T+  C+    ++
Sbjct: 387 TLKLEILTNLANEANISTLLREFQTYV--------KSQDKQFAAATIQTIGRCATNILEV 438

Query: 398 AANVIPVLMEFLSDNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRG 457
               +  L+  LS+ +E   A+ +  +++ +Q        I++ M ++  +I        
Sbjct: 439 TDTCLNGLVCLLSNRDEIVVAESVVVIKKLLQMQPAQHGEIIKHMAKLLDSITVPVARAS 498

Query: 458 ALWILGEYCSTKEDIQSVMTEIRRSLGEIPIVESEIKK 495
            LW++GE C   E +  +  ++ R + +    E ++ K
Sbjct: 499 ILWLIGENC---ERVPKIAPDVLRKMAKSFTSEDDLVK 533


>gi|37675283 adaptor-related protein complex 4, epsilon 1 subunit
           [Homo sapiens]
          Length = 1137

 Score = 60.5 bits (145), Expect = 7e-09
 Identities = 102/445 (22%), Positives = 186/445 (41%), Gaps = 83/445 (18%)

Query: 95  LHE----MILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLEHRHSY 150
           LHE    ++L+ +   KDLQ  N       L  + ++   E++  ++P I   L+H    
Sbjct: 124 LHESHELLLLLVNTVVKDLQSTNLVEVCMALTVVSQIFPCEMIPAVLPLIEDKLQHSKEI 183

Query: 151 VRRNAVLAIYTIYRNFEHLIPDAPELIHDFLVNEKDASCKRNAFMML--IHADQDRALDY 208
           VRR AVLA+Y       HLI  AP  +    +  + A C R+  +M   +H       + 
Sbjct: 184 VRRKAVLALYKF-----HLI--APNQVQHIHIKFRKALCDRDVGVMAASLHIYLRMIKEN 236

Query: 209 LSTCIDQVQTFGDILQLVI-----VELIYKVCHANPS----------------ERARFIR 247
            S   D   +F  IL+ V+     VE  Y   H+ P+                +  R   
Sbjct: 237 SSGYKDLTGSFVTILKQVVGGKLPVEFNY---HSVPAPWLQIQLLRILGLLGKDDQRTSE 293

Query: 248 CIYNLLQSS----------SPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNV 297
            +Y++L  S          + A+ +E   T+ ++      ++ AA+C I   +     N+
Sbjct: 294 LMYDVLDESLRRAELNHNVTYAILFECVHTVYSIYPKSELLEKAAKC-IGKFVLSPKINL 352

Query: 298 KLIVLDRL-IELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEEL 356
           K + L  L   +++ P      Q   M I+  L  PD  ++++TL+L   + +++N+  +
Sbjct: 353 KYLGLKALTYVIQQDPTLALQHQ---MTIIECLDHPDPIIKRETLELLYRITNAQNITVI 409

Query: 357 VIVL-------KKEVIKTNNVSE-HEDTDKY---RQLLVRTLHSC-----SVRFPDMAAN 400
           V  +       K+E +  N V +  E  +KY       ++T+++       V  PD+  N
Sbjct: 410 VQKMLEYLHQSKEEYVIVNLVGKIAELAEKYAPDNAWFIQTMNAVFSVGGDVMHPDIPNN 469

Query: 401 VIPVLMEFLSDNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALW 460
            + +L E   D  E     +      A+Q +     L +  M  VF+  + +++     W
Sbjct: 470 FLRLLAEGFDDETEDQQLRLY-----AVQSY-----LTLLDMENVFYPQRFLQVMS---W 516

Query: 461 ILGE--YCSTKEDIQSVMTEIRRSL 483
           +LGE  Y   KE  + V+ ++ + L
Sbjct: 517 VLGEYSYLLDKETPEEVIAKLYKLL 541



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 83/417 (19%), Positives = 153/417 (36%), Gaps = 41/417 (9%)

Query: 484  GEIPIVESEIKKEAGELKPEEEITVGPVQKLVTEMGTYATQSALSSSRPTKKEEDRPPLR 543
            G +P  ES+   E+G L   +E  +  V + +T+         L+ S+  K+++      
Sbjct: 714  GYLPKKESKTGDESGALPVPQESIMENVDQAITKKDQ---SQVLTQSKEEKEKQ------ 764

Query: 544  GFLLDGDFFVAASLATTLTKIALRYVALVQEKKKQNSFVAEAMLLMATILH----LGKSS 599
              LL    FV     +T+    L     V  K ++ S V EA     T  H       SS
Sbjct: 765  --LLASSLFVGLGSESTIN--LLGKADTVSHKFRRKSKVKEAKSGETTSTHNMTCSSFSS 820

Query: 600  LPKKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRQSLSHMLSAKLEEEKLSQKKESE 659
            L      DD               S  ++D  +KE ++    + S  L+ E L++    E
Sbjct: 821  LSNVAYEDDYY-------------SNTLHDTGDKELKKF--SLTSELLDSESLTELPLVE 865

Query: 660  KRNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSLLAAMGNTQRKEAADPLASKLNKVTQL 719
            K +        +S   L A N M         +   A  ++      +     ++     
Sbjct: 866  KFSYC-----SLSTPSLFANNNMEIFHPPQSTAASVAKESSLASSFLEETTEYIHSNAME 920

Query: 720  TGFSDPVYAEAYVHVNQYDIVLDVLVVNQTSDTLQNCTLELATLGDLKLVEKPSPLTLAP 779
               ++ +   +Y       +++   V N++   L++  LE+    + K+ E+P    L  
Sbjct: 921  VCNNETISVSSYKIWKDDCLLMVWSVTNKSGLELKSADLEIFPAENFKVTEQPG-CCLPV 979

Query: 780  HDFANIKANVKVASTENGIIFGNIVYDVSGAASDRNCVVLS-DIHIDIMDYIQPATCTDA 838
             +  + K+       E     GN+   +S    D +   L   +++ ++D+I+P   +  
Sbjct: 980  MEAESTKSFQYSVQIEKPFTEGNLTGFISYHMMDTHSAQLEFSVNLSLLDFIRPLKISSD 1039

Query: 839  EFRQMWAEFEWENKVTVNTNMVDLNDYLQHILKSTNMKCLTPEKALSGYCGFMAANL 895
            +F ++W  F   N V  N  M +    L   LK+   K       + G  G +A  L
Sbjct: 1040 DFGKLWLSF--ANDVKQNVKMSESQAALPSALKTLQQKLRLHIIEIIGNEGLLACQL 1094


>gi|71773010 adaptor-related protein complex 1, gamma 1 subunit
           isoform a [Homo sapiens]
          Length = 825

 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 87/477 (18%), Positives = 191/477 (40%), Gaps = 76/477 (15%)

Query: 99  ILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLA 158
           +L+ +  + DL H  +F++G  L  L  +  +E+   L   +   L+  +SY+R+ A L 
Sbjct: 101 LLMTNCIKNDLNHSTQFVQGLALCTLGCMGSSEMCRDLAGEVEKLLKTSNSYLRKKAALC 160

Query: 159 IYTIYRNFEHLIPDAPELIHDF------LVNEKD------------ASCKRNAFMMLIHA 200
                    H+I   PEL+  F      L+NEK+              C+R+  M+    
Sbjct: 161 AV-------HVIRKVPELMEMFLPATKNLLNEKNHGVLHTSVVLLTEMCERSPDMLAHFR 213

Query: 201 DQDRALDYLSTCIDQVQTFG------------DILQLVIVELIYKVCHANPSERARFIRC 248
             ++ +  L   +  +   G              LQ+ I+ L+ ++   N  + +  +  
Sbjct: 214 KNEKLVPQLVRILKNLIMSGYSPEHDVSGISDPFLQVRILRLL-RILGRNDDDSSEAMND 272

Query: 249 IYNLLQSSSP-------AVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLIV 301
           I   + +++        A+ YE   T++ + S  + ++  A   +   +  +D N++ + 
Sbjct: 273 ILAQVATNTETSKNVGNAILYETVLTIMDIKS-ESGLRVLAINILGRFLLNNDKNIRYVA 331

Query: 302 LDRLIEL--KEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELVIV 359
           L  L++    +H A +R  +  ++D L+ L   D+ ++++ ++L+  LV+  N+  ++  
Sbjct: 332 LTSLLKTVQTDHNAVQR-HRSTIVDCLKDL---DVSIKRRAMELSFALVNGNNIRGMM-- 385

Query: 360 LKKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLSDNNEAAAAD 419
             KE++   +  E E    ++      +   + ++       I  +M  L+        D
Sbjct: 386 --KELLYFLDSCEPE----FKADCASGIFLAAEKYAPSKRWHIDTIMRVLTTAGSYVRDD 439

Query: 420 VLEFVREAIQRFDNLRMLIVEKMLE-VFHAIKSVKIYRGALWILGEY--------CSTKE 470
            +  + + I     +    V+++ + +        + + A W +GEY        C  +E
Sbjct: 440 AVPNLIQLITNSVEMHAYTVQRLYKAILGDYSQQPLVQVAAWCIGEYGDLLVSGQCEEEE 499

Query: 471 DIQSVMTEIRRSLGEIPIVESEIKKEAG-------ELKPEEEITVGPVQKLVTEMGT 520
            IQ    E+   L  + I         G       +L      TV  ++K+V+  G+
Sbjct: 500 PIQVTEDEVLDILESVLISNMSTSVTRGYALTAIMKLSTRFTCTVNRIKKVVSIYGS 556


>gi|71772942 adaptor-related protein complex 1, gamma 1 subunit
           isoform b [Homo sapiens]
          Length = 822

 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 88/474 (18%), Positives = 191/474 (40%), Gaps = 73/474 (15%)

Query: 99  ILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLA 158
           +L+ +  + DL H  +F++G  L  L  +  +E+   L   +   L+  +SY+R+ A L 
Sbjct: 101 LLMTNCIKNDLNHSTQFVQGLALCTLGCMGSSEMCRDLAGEVEKLLKTSNSYLRKKAALC 160

Query: 159 IYTIYRNFEHLIPDAPELIHDF------LVNEKD------------ASCKRNAFMM---- 196
                    H+I   PEL+  F      L+NEK+              C+R+  M+    
Sbjct: 161 AV-------HVIRKVPELMEMFLPATKNLLNEKNHGVLHTSVVLLTEMCERSPDMLAHFR 213

Query: 197 -----LIHADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKVCHANPSERARFIRCIYN 251
                L+   ++  +   S   D        LQ+ I+ L+ ++   N  + +  +  I  
Sbjct: 214 KLVPQLVRILKNLIMSGYSPEHDVSGISDPFLQVRILRLL-RILGRNDDDSSEAMNDILA 272

Query: 252 LLQSSSP-------AVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLIVLDR 304
            + +++        A+ YE   T++ + S  + ++  A   +   +  +D N++ + L  
Sbjct: 273 QVATNTETSKNVGNAILYETVLTIMDIKS-ESGLRVLAINILGRFLLNNDKNIRYVALTS 331

Query: 305 LIEL--KEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELVIVLKK 362
           L++    +H A +R  +  ++D L+ L   D+ ++++ ++L+  LV+  N+  ++    K
Sbjct: 332 LLKTVQTDHNAVQR-HRSTIVDCLKDL---DVSIKRRAMELSFALVNGNNIRGMM----K 383

Query: 363 EVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLSDNNEAAAADVLE 422
           E++   +  E E    ++      +   + ++       I  +M  L+        D + 
Sbjct: 384 ELLYFLDSCEPE----FKADCASGIFLAAEKYAPSKRWHIDTIMRVLTTAGSYVRDDAVP 439

Query: 423 FVREAIQRFDNLRMLIVEKMLE-VFHAIKSVKIYRGALWILGEY--------CSTKEDIQ 473
            + + I     +    V+++ + +        + + A W +GEY        C  +E IQ
Sbjct: 440 NLIQLITNSVEMHAYTVQRLYKAILGDYSQQPLVQVAAWCIGEYGDLLVSGQCEEEEPIQ 499

Query: 474 SVMTEIRRSLGEIPIVESEIKKEAG-------ELKPEEEITVGPVQKLVTEMGT 520
               E+   L  + I         G       +L      TV  ++K+V+  G+
Sbjct: 500 VTEDEVLDILESVLISNMSTSVTRGYALTAIMKLSTRFTCTVNRIKKVVSIYGS 553


>gi|4503843 adaptor-related protein complex 1, gamma 2 subunit [Homo
           sapiens]
          Length = 785

 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 61/288 (21%), Positives = 118/288 (40%), Gaps = 35/288 (12%)

Query: 99  ILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLA 158
           +L+ ++ + DL    + ++G  L  L  +  AE+   L P +   L     YVR+ A+L 
Sbjct: 102 LLITNSIKNDLSQGIQPVQGLALCTLSTMGSAEMCRDLAPEVEKLLLQPSPYVRKKAILT 161

Query: 159 IYTIYRNFEHL----IPDAPELIHD--------------FLVNEKDASCK--RNAFMMLI 198
              + R    L    +P   +L+H+               L     A+ +  R     L+
Sbjct: 162 AVHMIRKVPELSSVFLPPCAQLLHERHHGILLGTITLITELCERSPAALRHFRKVVPQLV 221

Query: 199 HADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKVCHANPSERARFIRCIY-------N 251
           H  +       ST           LQ+ I+ L+ ++   N  E +  +  +        +
Sbjct: 222 HILRTLVTMGYSTEHSISGVSDPFLQVQILRLL-RILGRNHEESSETMNDLLAQVATNTD 280

Query: 252 LLQSSSPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLIVLDRLIEL--K 309
             +++  AV +E   T++ + SA   ++  A   +   +  SD N++ + L  L+ L   
Sbjct: 281 TSRNAGNAVLFETVLTIMDIRSA-AGLRVLAVNILGRFLLNSDRNIRYVALTSLLRLVQS 339

Query: 310 EHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELV 357
           +H A +R    +V      L   D  + ++ L+L+L LV+S NV  ++
Sbjct: 340 DHSAVQRHRPTVV----ECLRETDASLSRRALELSLALVNSSNVRAMM 383


>gi|166197671 adaptor-related protein complex 4, beta 1 subunit
           [Homo sapiens]
          Length = 739

 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 34/116 (29%), Positives = 54/116 (46%), Gaps = 6/116 (5%)

Query: 42  LKKVIIMILNGEKLPGLLMTIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILV 101
           +++VI  +  G  + G+ M +++    + D   KKL+ ++        PD  LL      
Sbjct: 33  IQRVIRYMTQGLDMSGVFMEMVKASATV-DIVQKKLVYLYMCTYAPLKPDLALL-----A 86

Query: 102 CDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVL 157
            +   KD   PN  +RG  LR +C L+   + E +   I   L  + SYVRR AVL
Sbjct: 87  INTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEYIQQPILNGLRDKASYVRRVAVL 142


>gi|109134349 coatomer protein complex, subunit gamma 2 [Homo
           sapiens]
          Length = 871

 Score = 37.4 bits (85), Expect = 0.067
 Identities = 52/274 (18%), Positives = 117/274 (42%), Gaps = 59/274 (21%)

Query: 97  EMILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAV 156
           ++I+V  +  KD+    +  RG  +R LC++ +  +L+ +   ++  +  + S V  +A+
Sbjct: 101 DVIIVTSSLTKDMTGKEDVYRGPAIRALCRITDGTMLQAIERYMKQAIVDKVSSVSSSAL 160

Query: 157 LA----IYTIYRNFEHLIPDAPE---------------LIHDFLVNEKDASCK------- 190
           ++    +   Y   +  I +A E               +++    N++ A  K       
Sbjct: 161 VSSLHMMKISYDVVKRWINEAQEAASSDNIMVQYHALGVLYHLRKNDRLAVSKMLNKFTK 220

Query: 191 -----RNAFMMLIH-----------ADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKV 234
                + A+ MLI              +    D++ +C+          ++VI E    +
Sbjct: 221 SGLKSQFAYCMLIRIASRLLKETEDGHESPLFDFIESCLRNKH------EMVIYEAASAI 274

Query: 235 CHANPSERARFIRCIYNLLQ----SSSPAVKYEAAGTLVTLS-SAPTAIKAAAQCYIDL- 288
            H  P+  AR +    ++LQ    S  PA++Y A  TL  ++   P+A+ A   C +DL 
Sbjct: 275 IHL-PNCTARELAPAVSVLQLFCSSPKPALRYAAVRTLNKVAMKHPSAVTA---CNLDLE 330

Query: 289 -IIKESDNNVKLIVLDRLIELKEHPAHERVLQDL 321
            +I +S+ ++  + +  L++     + +R+++ +
Sbjct: 331 NLITDSNRSIATLAITTLLKTGSESSVDRLMKQI 364


>gi|11559929 coatomer protein complex, subunit gamma 1 [Homo
           sapiens]
          Length = 874

 Score = 36.2 bits (82), Expect = 0.15
 Identities = 62/331 (18%), Positives = 137/331 (41%), Gaps = 42/331 (12%)

Query: 94  LLHEMILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLEHRHSYVRR 153
           +  ++I+V  +  KD+    +  RG  +R LC++ ++ +L+ +   ++  +  +   V  
Sbjct: 98  IAEDVIIVTSSLTKDMTGKEDNYRGPAVRALCQITDSTMLQAIERYMKQAIVDKVPSVSS 157

Query: 154 NAVLAIYTIYRNFEHLIPDAPELIHDFLVNEKDASCKRNAFMMLIHA--------DQDR- 204
           +A+++         HL+  + +++  + VNE   +   +  M+  HA          DR 
Sbjct: 158 SALVSSL-------HLLKCSFDVVKRW-VNEAQEAASSDNIMVQYHALGLLYHVRKNDRL 209

Query: 205 ALDYLSTCIDQVQTFGDILQLVIVELIYKVCHANPSER-ARFIRCIYNLLQSSSPAVKYE 263
           A++ + + + +          +++ +  K        R +     I + L++    V YE
Sbjct: 210 AVNKMISKVTRHGLKSPFAYCMMIRVASKQLEEEDGSRDSPLFDFIESCLRNKHEMVVYE 269

Query: 264 AAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLIVLDRLIEL-KEHP----AHERVL 318
           AA  +V L        A A   + L        ++   +  L ++  +HP    A    L
Sbjct: 270 AASAIVNLPGCSAKELAPAVSVLQLFCSSPKAALRYAAVRTLNKVAMKHPSAVTACNLDL 329

Query: 319 QDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELVIVLKKEVIKTNNVSEHEDTDK 378
           ++LV D  R ++T           LA+  +     E  +  L K++    +    E +D+
Sbjct: 330 ENLVTDSNRSIAT-----------LAITTLLKTGSESSIDRLMKQISSFMS----EISDE 374

Query: 379 YRQLLVRTLHSCSVRFPDMAANVIPVLMEFL 409
           ++ ++V+ + +   ++P   A    VLM FL
Sbjct: 375 FKVVVVQAISALCQKYPRKHA----VLMNFL 401


>gi|151301127 dynein, axonemal, heavy chain 7 [Homo sapiens]
          Length = 4024

 Score = 34.7 bits (78), Expect = 0.44
 Identities = 30/120 (25%), Positives = 55/120 (45%), Gaps = 8/120 (6%)

Query: 771  KPSPLTLAPHDFA-NIKANVKVASTENGIIFGNIVYDVS---GAASDRNCVVLSDIHIDI 826
            K  PLT AP  F  N  A++    +E  ++F NI+   S   GA +  +  V++++  DI
Sbjct: 3697 KTLPLTPAPEIFGMNANADITKDQSETQLLFDNILLTQSRSAGAGAKSSDEVVNEVASDI 3756

Query: 827  MDYIQPATCTDAEFRQMWAEFEWENKVTVNTNMVDLNDYLQHILKSTNMKCLTPEKALSG 886
            +  +      +A  R+    +      ++NT +V        +LK+    C+  +KA+ G
Sbjct: 3757 LGKLPNNFDIEAAMRRYPTTYTQ----SMNTVLVQEMGRFNKLLKTIRDSCVNIQKAIKG 3812


>gi|51093836 hypothetical protein LOC126859 isoform 1 [Homo sapiens]
          Length = 1012

 Score = 34.3 bits (77), Expect = 0.57
 Identities = 35/172 (20%), Positives = 79/172 (45%), Gaps = 21/172 (12%)

Query: 561 LTKIALRYVALVQEKKKQNSFVAEAMLLMATILHLGKSSLPKKPITDD--DVDRISL-CL 617
           + ++ L  + L ++  + +S+++     M T + L KS+   K  T+D  +VD++   C 
Sbjct: 741 VARLELDAIELTRKLYQYSSYLSSCCKGMVTAMALSKSTNSHKNATEDLYEVDKLKKECY 800

Query: 618 KVLSECSPLMNDIFNKECRQSLSHMLSAKLEEEKLSQKKESEKRNVTVQPDDPISFMQLT 677
           + ++ CS L+++I  ++        +   LEEE + +          ++P+   SF +  
Sbjct: 801 EWINTCSCLLSNIKGRKITLLTYEEIERLLEEEAVKE---------FIEPEIDESFKE-- 849

Query: 678 AKNEMNCKEDQFQLSLLAAMGNTQRKEAADPLASKLNKVTQLTGFSDPVYAE 729
             +E   KED+          N +R E     +++  K+ +  G  + V+++
Sbjct: 850 --DEEESKEDR-----KLQEENKERAEEQPSTSTEKEKLIRFIGEDENVHSK 894


>gi|95147555 microtubule-associated protein 1A [Homo sapiens]
          Length = 2803

 Score = 33.9 bits (76), Expect = 0.74
 Identities = 39/175 (22%), Positives = 74/175 (42%), Gaps = 9/175 (5%)

Query: 522 ATQSALSSSR-PTKKEEDRPPLRGFLLDGDFFVAASLATTLTKIALRYVALVQEKKKQNS 580
           ATQ  L+S   PT  +  +   R    D    + A+  T ++K+A R   + +  K+  S
Sbjct: 294 ATQKDLASGAVPTNLKPSKIKQRA---DSKESLKATTKTAVSKLAKREEVVEEGAKEARS 350

Query: 581 FVAEAMLLMATILHLGKSSLPKKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRQSLS 640
            +A+ +              P+KP   + V   S       +   + + +  K  ++ +S
Sbjct: 351 ELAKELAKTEKKAKESSEKPPEKPAKPERVKTESSEALKAEKRKLIKDKVGKKHLKEKIS 410

Query: 641 HMLSAKLEEEKLSQKKESEKRNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSLLA 695
                KLEE+K  +KKE +K    ++ D+     +  AK E   K+ + +L  ++
Sbjct: 411 -----KLEEKKDKEKKEIKKERKELKKDEGRKEEKKDAKKEEKRKDTKPELKKIS 460


>gi|64085252 hypothetical protein LOC145508 [Homo sapiens]
          Length = 1094

 Score = 33.9 bits (76), Expect = 0.74
 Identities = 38/194 (19%), Positives = 75/194 (38%), Gaps = 11/194 (5%)

Query: 472 IQSVMTEIRRSLGEIPIVESEIKKEAGELKPEEEITVGPVQKLVTEMGTYATQSALSSSR 531
           ++  + +   ++ E+    ++I KE  ELK +    +  ++ L  E+    T+ AL    
Sbjct: 500 LERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEE 559

Query: 532 PTKKEEDRPPLRGFLLDGDFFVAASLATTLTKIALRYVALVQEKKKQNSFVAEAMLLMAT 591
              KEE    ++    D +  V  SL T           L  E KKQ+   ++  +  A 
Sbjct: 560 LHSKEEKLRDIKSHQADLELEVKNSLDT--------IHRLESELKKQSKIQSQMKVEKA- 610

Query: 592 ILHLGKSSLPKKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRQSLSHMLSAKLEEEK 651
             HL +     K     D  ++    + + + S +  D+ NK   +  +     K   + 
Sbjct: 611 --HLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDL 668

Query: 652 LSQKKESEKRNVTV 665
            +Q K  ++   T+
Sbjct: 669 TAQAKSRDEETATI 682


>gi|239744625 PREDICTED: hypothetical protein XP_002343208 [Homo
           sapiens]
          Length = 333

 Score = 33.5 bits (75), Expect = 0.97
 Identities = 17/68 (25%), Positives = 33/68 (48%)

Query: 754 QNCTLELATLGDLKLVEKPSPLTLAPHDFANIKANVKVASTENGIIFGNIVYDVSGAASD 813
           +NCT  L   G   +VE+     L   DF +++ N+ V   E  ++ G+++   SGA  +
Sbjct: 242 KNCTSHLVDEGGKLVVEELDLFALFRPDFLDLRVNLHVEGGEQALVDGDLLNSPSGADGE 301

Query: 814 RNCVVLSD 821
               + ++
Sbjct: 302 ARATLTTE 309


>gi|127138957 zinc finger protein 537 [Homo sapiens]
          Length = 1081

 Score = 33.5 bits (75), Expect = 0.97
 Identities = 31/145 (21%), Positives = 56/145 (38%), Gaps = 9/145 (6%)

Query: 469 KEDIQSVMTEIRRSLGEIPIVESEIKKEAGELKPEEEITVGPVQKLVTEMGTYATQSALS 528
           K +  ++   +++   ++  VE ++K+  G+L P +  T  P     +E+G      A S
Sbjct: 604 KTNFHAMEELVKKVTEKVAKVEEKMKEPDGKLSPPKRATPSPCS---SEVGEPIKMEASS 660

Query: 529 SSRPTKKEEDRPPLRGFLLDGDFFV-----AASLATTLTKIALRYVALVQEKKKQNSFVA 583
                 +E    P R    DG            L   L        A++ +   +  FV 
Sbjct: 661 DGGFRSQENSPSPPRDGCKDGSPLAEPVENGKELVKPLASSLSGSTAIITDHPPEQPFVN 720

Query: 584 EAMLLMATI-LHLGKSSLPKKPITD 607
               L + + +HLGK++ P  P  D
Sbjct: 721 PLSALQSVMNIHLGKAAKPSLPALD 745


>gi|109659847 filamin A interacting protein 1-like isoform 3 [Homo
           sapiens]
          Length = 1133

 Score = 33.1 bits (74), Expect = 1.3
 Identities = 27/109 (24%), Positives = 54/109 (49%), Gaps = 7/109 (6%)

Query: 609 DVDRISLCLKVLSECSPLMNDIFNKECRQSLSHMLSAKLEEEKLSQKKESEK-RNVTVQP 667
           +V+++S  +  L +    + D FNK  ++  S  L   LE+E+++ K+ S++  ++ V+ 
Sbjct: 416 EVEKLSKRIMALEK----LEDAFNKSKQECYS--LKCNLEKERMTTKQLSQELESLKVRI 469

Query: 668 DDPISFMQLTAKNEMNCKEDQFQLSLLAAMGNTQRKEAADPLASKLNKV 716
            +  +      K E   KED  +L  L  M   +RK  ++ L    +K+
Sbjct: 470 KELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKL 518


>gi|109659849 filamin A interacting protein 1-like isoform 2 [Homo
           sapiens]
          Length = 893

 Score = 33.1 bits (74), Expect = 1.3
 Identities = 27/109 (24%), Positives = 54/109 (49%), Gaps = 7/109 (6%)

Query: 609 DVDRISLCLKVLSECSPLMNDIFNKECRQSLSHMLSAKLEEEKLSQKKESEK-RNVTVQP 667
           +V+++S  +  L +    + D FNK  ++  S  L   LE+E+++ K+ S++  ++ V+ 
Sbjct: 176 EVEKLSKRIMALEK----LEDAFNKSKQECYS--LKCNLEKERMTTKQLSQELESLKVRI 229

Query: 668 DDPISFMQLTAKNEMNCKEDQFQLSLLAAMGNTQRKEAADPLASKLNKV 716
            +  +      K E   KED  +L  L  M   +RK  ++ L    +K+
Sbjct: 230 KELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKL 278


>gi|109659845 filamin A interacting protein 1-like isoform 1 [Homo
           sapiens]
          Length = 1135

 Score = 33.1 bits (74), Expect = 1.3
 Identities = 27/109 (24%), Positives = 54/109 (49%), Gaps = 7/109 (6%)

Query: 609 DVDRISLCLKVLSECSPLMNDIFNKECRQSLSHMLSAKLEEEKLSQKKESEK-RNVTVQP 667
           +V+++S  +  L +    + D FNK  ++  S  L   LE+E+++ K+ S++  ++ V+ 
Sbjct: 416 EVEKLSKRIMALEK----LEDAFNKSKQECYS--LKCNLEKERMTTKQLSQELESLKVRI 469

Query: 668 DDPISFMQLTAKNEMNCKEDQFQLSLLAAMGNTQRKEAADPLASKLNKV 716
            +  +      K E   KED  +L  L  M   +RK  ++ L    +K+
Sbjct: 470 KELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKL 518


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score = 33.1 bits (74), Expect = 1.3
 Identities = 51/268 (19%), Positives = 118/268 (44%), Gaps = 29/268 (10%)

Query: 471  DIQSVMTEIRRSLGEIPIVESEIKKEAGELKPEEEITVGPVQKL---VTEMGTYATQSAL 527
            ++Q  M+E+++ + EI  +++E+K +   L+  E   +   QKL     E+ +   +  +
Sbjct: 1145 NVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKV 1204

Query: 528  SSSRPTKKEEDRPPLRGFLLDGDFFVAASLATTLTKIALRYVALVQEKKKQNSF---VAE 584
                    E +R  LRG++ +    + A+   T  ++ + ++ L + ++  +     V+E
Sbjct: 1205 LKELQKSFETERDHLRGYIRE----IEATGLQTKEELKIAHIHLKEHQETIDELRRSVSE 1260

Query: 585  AMLLMATILHLGKSSLPKK---PITDDDVDRISLCLKVLSECSPLMNDI-FNKECRQSLS 640
                +     L KS    +   P+  ++ + +   +K +SE    MN++    E   +  
Sbjct: 1261 KTAQIINTQDLEKSHTKLQEEIPVLHEEQELLP-NVKEVSETQETMNELELLTEQSTTKD 1319

Query: 641  HMLSAKLEEEKLS-----QKKESEKRNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSLLA 695
                A++E E+L      Q+ + E +++T + D+       T K  +  K DQ +  +  
Sbjct: 1320 STTLARIEMERLRLNEKFQESQEEIKSLTKERDN-----LKTIKEALEVKHDQLKEHIRE 1374

Query: 696  AMGNTQ----RKEAADPLASKLNKVTQL 719
             +   Q    ++E +  +  K N+ T++
Sbjct: 1375 TLAKIQESQSKQEQSLNMKEKDNETTKI 1402


>gi|19923599 calmin [Homo sapiens]
          Length = 1002

 Score = 33.1 bits (74), Expect = 1.3
 Identities = 57/208 (27%), Positives = 94/208 (45%), Gaps = 20/208 (9%)

Query: 471 DIQSVMTEIRRSLGEIPIVESEIKKEAGELKPEE----EITVGPVQK-----LVTEMG-- 519
           D QS+MT + + L   P +E+E   ++ +  P E     I   P ++     ++TE G  
Sbjct: 275 DEQSIMTYVAQFLERFPELEAEDIFDSDKEVPIESTFVRIKETPSEQESKVFVLTENGER 334

Query: 520 TYATQSALSSSRPTKKEE-DRP-PLRGFLLDGDFFVAASLATT--LTKIALRYVALVQEK 575
           TY      S   P+K    D+P  ++ F LDG    A S ++T  + +I  + +     K
Sbjct: 335 TYTVNHETSHPPPSKVFVCDKPESMKEFRLDGVSSHALSDSSTEFMHQIIDQVLQGGPGK 394

Query: 576 KKQNSFVAEAMLLMATILHLGKS-SLPKKPITDDDVD--RISLCLKVLSECSPLMNDIFN 632
               S  +    ++++    G+S SLP K     + D  +   C K LS C      +  
Sbjct: 395 TSDISEPSPESSILSSRKENGRSNSLPIKKTVHFEADTYKDPFCSKNLSLCFEGSPRVAK 454

Query: 633 KECRQSLSHMLSAKLEEEKLSQKKESEK 660
           +  RQ   H+L+ ++ EEK  QK+ES K
Sbjct: 455 ESLRQD-GHVLAVEVAEEK-EQKQESSK 480


>gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1
           [Homo sapiens]
          Length = 878

 Score = 32.7 bits (73), Expect = 1.7
 Identities = 35/143 (24%), Positives = 65/143 (45%), Gaps = 5/143 (3%)

Query: 396 DMAANVIPVLMEFLSDNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIY 455
           D+  N +  L   LS  + AA    LE + +    F  LR + V  M+      K    +
Sbjct: 219 DIEKNYMSPLRLVLSPADMAAVFINLEDLIKVHHSF--LRAIDVSVMVGGSTLAKVFLDF 276

Query: 456 RGALWILGEYCSTKEDIQSVMTEIRRSLGEI--PIVESEIKKEAGELKPEEEITVGPVQK 513
           +  L I GEYCS  E  Q+ + ++  S  +    + E  +K + G+ K ++ + V P+Q+
Sbjct: 277 KERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVV-PMQR 335

Query: 514 LVTEMGTYATQSALSSSRPTKKE 536
           ++          + S+ RP +++
Sbjct: 336 VLKYHLLLKELLSHSAERPERQQ 358


>gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2
           [Homo sapiens]
          Length = 839

 Score = 32.7 bits (73), Expect = 1.7
 Identities = 35/143 (24%), Positives = 65/143 (45%), Gaps = 5/143 (3%)

Query: 396 DMAANVIPVLMEFLSDNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIY 455
           D+  N +  L   LS  + AA    LE + +    F  LR + V  M+      K    +
Sbjct: 214 DIEKNYMSPLRLVLSPADMAAVFINLEDLIKVHHSF--LRAIDVSVMVGGSTLAKVFLDF 271

Query: 456 RGALWILGEYCSTKEDIQSVMTEIRRSLGEI--PIVESEIKKEAGELKPEEEITVGPVQK 513
           +  L I GEYCS  E  Q+ + ++  S  +    + E  +K + G+ K ++ + V P+Q+
Sbjct: 272 KERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVV-PMQR 330

Query: 514 LVTEMGTYATQSALSSSRPTKKE 536
           ++          + S+ RP +++
Sbjct: 331 VLKYHLLLKELLSHSAERPERQQ 353


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.134    0.378 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,836,657
Number of Sequences: 37866
Number of extensions: 1380776
Number of successful extensions: 4113
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 18
Number of HSP's successfully gapped in prelim test: 33
Number of HSP's that attempted gapping in prelim test: 4047
Number of HSP's gapped (non-prelim): 83
length of query: 953
length of database: 18,247,518
effective HSP length: 112
effective length of query: 841
effective length of database: 14,006,526
effective search space: 11779488366
effective search space used: 11779488366
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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