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Search of human proteins with 221316593
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|221316593 cadherin 17 precursor [Homo sapiens]
(832 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|221316595 cadherin 17 precursor [Homo sapiens] 1669 0.0
gi|221316593 cadherin 17 precursor [Homo sapiens] 1669 0.0
gi|4757956 cadherin 16 precursor [Homo sapiens] 350 4e-96
gi|14589893 cadherin 4, type 1 preproprotein [Homo sapiens] 259 7e-69
gi|14589889 cadherin 2, type 1 preproprotein [Homo sapiens] 255 1e-67
gi|148539848 desmocollin 3 isoform Dsc3b preproprotein [Homo sap... 246 5e-65
gi|148539846 desmocollin 3 isoform Dsc3a preproprotein [Homo sap... 246 5e-65
gi|13435366 desmocollin 2 isoform Dsc2b preproprotein [Homo sapi... 243 4e-64
gi|13435364 desmocollin 2 isoform Dsc2a preproprotein [Homo sapi... 243 4e-64
gi|4502719 cadherin 13 preproprotein [Homo sapiens] 238 2e-62
gi|4826671 cadherin 18, type 2 preproprotein [Homo sapiens] 218 1e-56
gi|4757960 cadherin 1, type 1 preproprotein [Homo sapiens] 212 1e-54
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 209 1e-53
gi|16306530 cadherin 10, type 2 preproprotein [Homo sapiens] 207 3e-53
gi|4826669 cadherin 15 preproprotein [Homo sapiens] 206 6e-53
gi|29570800 cadherin-like 26 isoform a [Homo sapiens] 206 9e-53
gi|16306532 cadherin 11, type 2 preproprotein [Homo sapiens] 204 2e-52
gi|4826702 desmocollin 1 isoform Dsc1b preproprotein [Homo sapiens] 203 6e-52
gi|13435361 desmocollin 1 isoform Dsc1a preproprotein [Homo sapi... 203 6e-52
gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens] 202 1e-51
gi|16306539 cadherin 8, type 2 preproprotein [Homo sapiens] 202 1e-51
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens] 196 6e-50
gi|16445393 cadherin 12, type 2 preproprotein [Homo sapiens] 196 7e-50
gi|32880203 cadherin-like 24 isoform 2 [Homo sapiens] 196 1e-49
gi|4826673 cadherin 6, type 2 preproprotein [Homo sapiens] 193 5e-49
gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo... 192 8e-49
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 190 5e-48
gi|14589891 cadherin 3, type 1 preproprotein [Homo sapiens] 189 9e-48
gi|16306487 cadherin 7, type 2 preproprotein [Homo sapiens] 186 1e-46
gi|16306489 cadherin 7, type 2 preproprotein [Homo sapiens] 186 1e-46
>gi|221316595 cadherin 17 precursor [Homo sapiens]
Length = 832
Score = 1669 bits (4321), Expect = 0.0
Identities = 832/832 (100%), Positives = 832/832 (100%)
Query: 1 MILQAHLHSLCLLMLYLATGYGQEGKFSGPLKPMTFSIYEGQEPSQIIFQFKANPPAVTF 60
MILQAHLHSLCLLMLYLATGYGQEGKFSGPLKPMTFSIYEGQEPSQIIFQFKANPPAVTF
Sbjct: 1 MILQAHLHSLCLLMLYLATGYGQEGKFSGPLKPMTFSIYEGQEPSQIIFQFKANPPAVTF 60
Query: 61 ELTGETDNIFVIEREGLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDIN 120
ELTGETDNIFVIEREGLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDIN
Sbjct: 61 ELTGETDNIFVIEREGLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDIN 120
Query: 121 DNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYF 180
DNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYF
Sbjct: 121 DNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYF 180
Query: 181 QINNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTENIWK 240
QINNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTENIWK
Sbjct: 181 QINNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTENIWK 240
Query: 241 APKPVEMVENSTDPHPIKITQVRWNDPGAQYSLVDKEKLPRFPFSIDQEGDIYVTQPLDR 300
APKPVEMVENSTDPHPIKITQVRWNDPGAQYSLVDKEKLPRFPFSIDQEGDIYVTQPLDR
Sbjct: 241 APKPVEMVENSTDPHPIKITQVRWNDPGAQYSLVDKEKLPRFPFSIDQEGDIYVTQPLDR 300
Query: 301 EEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERLGNSIG 360
EEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERLGNSIG
Sbjct: 301 EEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERLGNSIG 360
Query: 361 TLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTPQYNL 420
TLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTPQYNL
Sbjct: 361 TLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTPQYNL 420
Query: 421 TIEVSDKDFKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQATDADEP 480
TIEVSDKDFKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQATDADEP
Sbjct: 421 TIEVSDKDFKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQATDADEP 480
Query: 481 FTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVSNIVFKAENPEPLV 540
FTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVSNIVFKAENPEPLV
Sbjct: 481 FTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVSNIVFKAENPEPLV 540
Query: 541 FGVKYNASSFAKFTLIVTDVNEAPQFSQHVFQAKVSEDVAIGTKVGNVTAKDPEGLDISY 600
FGVKYNASSFAKFTLIVTDVNEAPQFSQHVFQAKVSEDVAIGTKVGNVTAKDPEGLDISY
Sbjct: 541 FGVKYNASSFAKFTLIVTDVNEAPQFSQHVFQAKVSEDVAIGTKVGNVTAKDPEGLDISY 600
Query: 601 SLRGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSLSSVSEFHLILMDV 660
SLRGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSLSSVSEFHLILMDV
Sbjct: 601 SLRGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSLSSVSEFHLILMDV 660
Query: 661 NDNPPRLAKDYTGLFFCHPLSAPGSLIFEATDDDQHLFRGPHFTFSLGSGSLQNDWEVSK 720
NDNPPRLAKDYTGLFFCHPLSAPGSLIFEATDDDQHLFRGPHFTFSLGSGSLQNDWEVSK
Sbjct: 661 NDNPPRLAKDYTGLFFCHPLSAPGSLIFEATDDDQHLFRGPHFTFSLGSGSLQNDWEVSK 720
Query: 721 INGTHARLSTRHTEFEEREYVVLIRINDGGRPPLEGIVSLPVTFCSCVEGSCFRPAGHQT 780
INGTHARLSTRHTEFEEREYVVLIRINDGGRPPLEGIVSLPVTFCSCVEGSCFRPAGHQT
Sbjct: 721 INGTHARLSTRHTEFEEREYVVLIRINDGGRPPLEGIVSLPVTFCSCVEGSCFRPAGHQT 780
Query: 781 GIPTVGMAVGILLTTLLVIGIILAVVFIRIKKDKGKDNVESAQASEVKPLRS 832
GIPTVGMAVGILLTTLLVIGIILAVVFIRIKKDKGKDNVESAQASEVKPLRS
Sbjct: 781 GIPTVGMAVGILLTTLLVIGIILAVVFIRIKKDKGKDNVESAQASEVKPLRS 832
>gi|221316593 cadherin 17 precursor [Homo sapiens]
Length = 832
Score = 1669 bits (4321), Expect = 0.0
Identities = 832/832 (100%), Positives = 832/832 (100%)
Query: 1 MILQAHLHSLCLLMLYLATGYGQEGKFSGPLKPMTFSIYEGQEPSQIIFQFKANPPAVTF 60
MILQAHLHSLCLLMLYLATGYGQEGKFSGPLKPMTFSIYEGQEPSQIIFQFKANPPAVTF
Sbjct: 1 MILQAHLHSLCLLMLYLATGYGQEGKFSGPLKPMTFSIYEGQEPSQIIFQFKANPPAVTF 60
Query: 61 ELTGETDNIFVIEREGLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDIN 120
ELTGETDNIFVIEREGLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDIN
Sbjct: 61 ELTGETDNIFVIEREGLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDIN 120
Query: 121 DNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYF 180
DNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYF
Sbjct: 121 DNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYF 180
Query: 181 QINNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTENIWK 240
QINNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTENIWK
Sbjct: 181 QINNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTENIWK 240
Query: 241 APKPVEMVENSTDPHPIKITQVRWNDPGAQYSLVDKEKLPRFPFSIDQEGDIYVTQPLDR 300
APKPVEMVENSTDPHPIKITQVRWNDPGAQYSLVDKEKLPRFPFSIDQEGDIYVTQPLDR
Sbjct: 241 APKPVEMVENSTDPHPIKITQVRWNDPGAQYSLVDKEKLPRFPFSIDQEGDIYVTQPLDR 300
Query: 301 EEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERLGNSIG 360
EEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERLGNSIG
Sbjct: 301 EEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERLGNSIG 360
Query: 361 TLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTPQYNL 420
TLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTPQYNL
Sbjct: 361 TLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTPQYNL 420
Query: 421 TIEVSDKDFKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQATDADEP 480
TIEVSDKDFKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQATDADEP
Sbjct: 421 TIEVSDKDFKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQATDADEP 480
Query: 481 FTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVSNIVFKAENPEPLV 540
FTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVSNIVFKAENPEPLV
Sbjct: 481 FTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVSNIVFKAENPEPLV 540
Query: 541 FGVKYNASSFAKFTLIVTDVNEAPQFSQHVFQAKVSEDVAIGTKVGNVTAKDPEGLDISY 600
FGVKYNASSFAKFTLIVTDVNEAPQFSQHVFQAKVSEDVAIGTKVGNVTAKDPEGLDISY
Sbjct: 541 FGVKYNASSFAKFTLIVTDVNEAPQFSQHVFQAKVSEDVAIGTKVGNVTAKDPEGLDISY 600
Query: 601 SLRGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSLSSVSEFHLILMDV 660
SLRGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSLSSVSEFHLILMDV
Sbjct: 601 SLRGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSLSSVSEFHLILMDV 660
Query: 661 NDNPPRLAKDYTGLFFCHPLSAPGSLIFEATDDDQHLFRGPHFTFSLGSGSLQNDWEVSK 720
NDNPPRLAKDYTGLFFCHPLSAPGSLIFEATDDDQHLFRGPHFTFSLGSGSLQNDWEVSK
Sbjct: 661 NDNPPRLAKDYTGLFFCHPLSAPGSLIFEATDDDQHLFRGPHFTFSLGSGSLQNDWEVSK 720
Query: 721 INGTHARLSTRHTEFEEREYVVLIRINDGGRPPLEGIVSLPVTFCSCVEGSCFRPAGHQT 780
INGTHARLSTRHTEFEEREYVVLIRINDGGRPPLEGIVSLPVTFCSCVEGSCFRPAGHQT
Sbjct: 721 INGTHARLSTRHTEFEEREYVVLIRINDGGRPPLEGIVSLPVTFCSCVEGSCFRPAGHQT 780
Query: 781 GIPTVGMAVGILLTTLLVIGIILAVVFIRIKKDKGKDNVESAQASEVKPLRS 832
GIPTVGMAVGILLTTLLVIGIILAVVFIRIKKDKGKDNVESAQASEVKPLRS
Sbjct: 781 GIPTVGMAVGILLTTLLVIGIILAVVFIRIKKDKGKDNVESAQASEVKPLRS 832
>gi|4757956 cadherin 16 precursor [Homo sapiens]
Length = 829
Score = 350 bits (897), Expect = 4e-96
Identities = 234/773 (30%), Positives = 390/773 (50%), Gaps = 21/773 (2%)
Query: 66 TDNIFVIERE-GLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNRP 124
T+ F ++ + G L RALDRE ++ + LQV +G ++ GP P+ + VKD ND P
Sbjct: 65 TEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVP 124
Query: 125 TFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQINN 184
F Q+ Y + + +RPG PFL++ A+D D+P T N L + I+ Q P + FQ+
Sbjct: 125 HFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEP 184
Query: 185 KTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTENIWKAPKP 244
+ GA++L+ +GS L+ A +Y L++ VKDMG Q+ + T +V++ + E+ W + +P
Sbjct: 185 RLGALALSPKGSTSLDHALERTYQLLVQVKDMGDQA-SGHQATATVEVSIIESTWVSLEP 243
Query: 245 VEMVENSTDPHPIKITQVRWNDPGAQYSLVDKEKLPRFPFSIDQEGDIYVTQPLDREEKD 304
+ + EN +P + QV W+ Y L E P PF ++ EG++YVT+ LDRE +
Sbjct: 244 IHLAENLKVLYPHHMAQVHWSGGDVHYHL---ESHPPGPFEVNAEGNLYVTRELDREAQA 300
Query: 305 AYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERLGNSIGTLTA 364
Y+ A++ +G+ + PLE+HV V D NDN P CP + E G + L+A
Sbjct: 301 EYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVPICPPRDPTVSIPELSPPGTEVTRLSA 360
Query: 365 HDRDEENTANSFLNYRIVEQTPKLPMDG-LFLIQTYAGMLQLAKQSLKK-QDTPQYNLTI 422
D D + NS + Y+++ P+ ++G F + +G + L L+ Q+ L +
Sbjct: 361 EDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDPTSGSVTLGVLPLRAGQNILLLVLAM 420
Query: 423 EVSDKD--FKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQATDAD-E 479
+++ + F + C V++ V DIND P F S G ++L ED G+ + + A DAD E
Sbjct: 421 DLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPISLPEDVEPGTLVAMLTAIDADLE 480
Query: 480 PFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVSNIVFKAENPEPL 539
P + + I +GD+EG G+D +P + + + K L +E A +V ++ L
Sbjct: 481 P--AFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSYEAAPSHEVVVVVQSVAKL 538
Query: 540 VFGVKYNASSFAKFTLIVTDVNEAPQFSQHVFQAKVSEDVAIGTKVGNVTAKDPEGLDIS 599
V G + A T++V V P+ Q ++A V G+ + + DP +
Sbjct: 539 V-GPGPGPGATATVTVLVERVMPPPKLDQESYEASVPISAPAGSFLLTIQPSDPISRTLR 597
Query: 600 YSLRGDTRGWLKIDHVTGEIFSVAPLD-REAGSPYRVQVVATEVGGSSLSSVSEFHLILM 658
+SL D+ GWL I+ +GE+ + L + G Y V V A + LS+ + + +
Sbjct: 598 FSLVNDSEGWLCIEKFSGEVHTAQSLQGAQPGDTYTVLVEAQDTDEPRLSASAPLVIHFL 657
Query: 659 DVNDNPPRLAKDYTGLFFCHPLSAPGSLIF-EATDDDQHLFRGPHFTFSLG-SGSLQNDW 716
P + C P G ++ + D D GP ++F+LG + ++Q DW
Sbjct: 658 KAPPAPALTLAPVPSQYLCTPRQDHGLIVSGPSKDPDLASGHGP-YSFTLGPNPTVQRDW 716
Query: 717 EVSKINGTHARLSTRHTEFEEREYVVLIRINDGGRPPLEGIVSLPVTFCSC-VEGSCFRP 775
+ +NG+HA L+ E RE+++ + ++ + + + V C C VEG C R
Sbjct: 717 RLQTLNGSHAYLTLALHWVEPREHIIPVVVSHNAQ---MWQLLVRVIVCRCNVEGQCMRK 773
Query: 776 AGHQTGIPTVGMAVGILLTTLLVIGIILAVVFIRIKKDKGKDNVESAQASEVK 828
G G+PT AVGIL+ TL+ IGI L ++F + KD + A + +K
Sbjct: 774 VGRMKGMPTKLSAVGILVGTLVAIGIFLILIFTHWTMSRKKDPDQPADSVPLK 826
Score = 80.1 bits (196), Expect = 8e-15
Identities = 112/444 (25%), Positives = 182/444 (40%), Gaps = 61/444 (13%)
Query: 58 VTFELTGETDNIFVIEREGLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVK 117
V + L F + EG LY R LDRE ++ + LQV A +++G P+ + + V
Sbjct: 268 VHYHLESHPPGPFEVNAEGNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVM 327
Query: 118 DINDNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMIN-N 176
D NDN P S+ + S PG ++A D D P +PN + YQ++ P
Sbjct: 328 DENDNVPICPPRDPTVSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVE 387
Query: 177 VMYFQINNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTE 236
FQ++ +G+++L G L +N L++ D+ G +E FS T V++ VT+
Sbjct: 388 GRAFQVDPTSGSVTL---GVLPLRAGQN--ILLLVLAMDLAG-AEGGFSSTCEVEVAVTD 441
Query: 237 NIWKAPKPVEMVENSTDPHPIKITQVRWNDPG---AQYSLVDKEKLPRF---PFSIDQEG 290
AP E + + P I+ +PG A + +D + P F F+I++ G
Sbjct: 442 INDHAP---EFITSQIGP----ISLPEDVEPGTLVAMLTAIDADLEPAFRLMDFAIER-G 493
Query: 291 DIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQ 350
D T LD E +V + K+ LSY PS V VQ
Sbjct: 494 DTEGTFGLDWEPDSGHVRLRLCKN-----LSY---------------EAAPSHEVVVVVQ 533
Query: 351 ENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSL 410
S+ L TA + V PKL ++Y + ++ +
Sbjct: 534 -------SVAKLVGPGPGPGATATVTVLVERVMPPPKLDQ------ESYEASVPISAPA- 579
Query: 411 KKQDTPQYNLTIEVSDKDFKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTIL 470
+ LTI+ SD +TL F +N + I F + +L + +
Sbjct: 580 -----GSFLLTIQPSDPISRTLRFSLVNDSEGWLCIEKFSGEVHTAQSLQGAQPGDTYTV 634
Query: 471 TIQATDADEP-FTGSSKILYHIIK 493
++A D DEP + S+ ++ H +K
Sbjct: 635 LVEAQDTDEPRLSASAPLVIHFLK 658
>gi|14589893 cadherin 4, type 1 preproprotein [Homo sapiens]
Length = 916
Score = 259 bits (662), Expect = 7e-69
Identities = 176/611 (28%), Positives = 283/611 (46%), Gaps = 29/611 (4%)
Query: 239 WKAPKPVEMVENSTDPHPIKITQVRW---NDPGAQYSL--VDKEKLPRFPFSIDQ-EGDI 292
W P P+ + ENS P P ++ ++R ND +YS+ V ++ P FSID G +
Sbjct: 171 WVIP-PINVPENSRGPFPQQLVRIRSDKDNDIPIRYSITGVGADQPPMEVFSIDSMSGRM 229
Query: 293 YVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQEN 352
YVT+P+DREE +Y A A D G + P+++++ V D+NDN P + V V E
Sbjct: 230 YVTRPMDREEHASYHLRAHAVDMNGNKVENPIDLYIYVIDMNDNRPEFINQVYNGSVDEG 289
Query: 353 ERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKK 412
+ G + T+TA+D D+ TAN + YRIV QTP+ P +F I + G + L +
Sbjct: 290 SKPGTYVMTVTANDADDSTTANGMVRYRIVTQTPQSPSQNMFTINSETGDIVTVAAGLDR 349
Query: 413 QDTPQYNLTIEVSDKD------FKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIG 466
+ QY + ++ +D + I V D+ND P F S + + +
Sbjct: 350 EKVQQYTVIVQATDMEGNLNYGLSNTATAIITVTDVNDNPPEFTASTFAGEV--PENRVE 407
Query: 467 STILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAV 526
+ + + D D+P + + +Y II GD G V TDP TN G V + K +D+E
Sbjct: 408 TVVANLTVMDRDQPHSPNWNAVYRIISGDPSGHFSVRTDPVTNEGMVTVVKAVDYELNRA 467
Query: 527 SNIVFKAENPEPLVFGVKYNASSFAKFTLIVTDVNEAPQFSQHVFQAKVSEDVAIGTKVG 586
+ N PL G++ + S A T+ + D+NEAP F + ++ E V GT +
Sbjct: 468 FMLTVMVSNQAPLASGIQMSFQSTAGVTISIMDINEAPYFPSNHKLIRLEEGVPPGTVLT 527
Query: 587 NVTAKDPEGL---DISYSLRGDTRGWLKIDHVTGEIFSVAPLDREA----GSPYRVQVVA 639
+A DP+ + YS D WL I+ G+I + A LDRE+ + Y +A
Sbjct: 528 TFSAVDPDRFMQQAVRYSKLSDPASWLHINATNGQITTAAVLDRESLYTKNNVYEATFLA 587
Query: 640 TEVGGSSLSSVSEFHLILMDVNDNPPRLAKDYTGLFFCHPLSAPGSLIFEATDDDQHLFR 699
+ G S + L+D+NDN P L + L+A + A D D
Sbjct: 588 ADNGIPPASGTGTLQIYLIDINDNAPELLPKEAQICEKPNLNA---INITAADADVDPNI 644
Query: 700 GPH-FTFSLGSGSLQNDWEVSKINGTHARLSTRHTEFEEREYVVLIRINDGGRPPLEGIV 758
GP+ F +++ +W ++++NG +A+LS R E Y V I + D G PPL
Sbjct: 645 GPYVFELPFVPAAVRKNWTITRLNGDYAQLSLRILYLEAGMYDVPIIVTDSGNPPLSNTS 704
Query: 759 SLPVTFCSCVEGSCFRPAGHQTGIPTVGMAVGILLTTLLVIGIILAVVFIRIKKDKGKDN 818
+ V C C + G + G+ G ++ L+ I I+L +V + + K ++
Sbjct: 705 IIKVKVCPCDDNGDCTTIG---AVAAAGLGTGAIVAILICILILLTMVLLFVMWMKRREK 761
Query: 819 VESAQASEVKP 829
+ + P
Sbjct: 762 ERHTKQLLIDP 772
Score = 127 bits (319), Expect = 4e-29
Identities = 129/481 (26%), Positives = 208/481 (43%), Gaps = 62/481 (12%)
Query: 41 GQEPSQI--IFQFKANPPAVTFELTGETDN-----IFVIER-EGLLYYNRALDRETRSTH 92
G P Q+ I K N + + +TG + +F I+ G +Y R +DRE +++
Sbjct: 184 GPFPQQLVRIRSDKDNDIPIRYSITGVGADQPPMEVFSIDSMSGRMYVTRPMDREEHASY 243
Query: 93 NLQVAALDANGIIVEGPVPITIKVKDINDNRPTFLQSKYEGSVRQNSRPGKPFLYVNATD 152
+L+ A+D NG VE P+ + I V D+NDNRP F+ Y GSV + S+PG + V A D
Sbjct: 244 HLRAHAVDMNGNKVENPIDLYIYVIDMNDNRPEFINQVYNGSVDEGSKPGTYVMTVTAND 303
Query: 153 LDDPATPNGQLYYQIVIQLPMINNVMYFQINNKTGAISLTREGSQELNPAKNPSYNLVIS 212
DD T NG + Y+IV Q P + F IN++TG I G L+ K Y +++
Sbjct: 304 ADDSTTANGMVRYRIVTQTPQSPSQNMFTINSETGDIVTVAAG---LDREKVQQYTVIVQ 360
Query: 213 VKDMGGQSENSFSDTTSVDIIVTENIWKAPK------PVEMVENSTDPHPIKITQVRWND 266
DM G S+T + I VT+ P+ E+ EN + +T + +
Sbjct: 361 ATDMEGNLNYGLSNTATAIITVTDVNDNPPEFTASTFAGEVPENRVETVVANLTVMDRDQ 420
Query: 267 P-----GAQYSLVDKEKLPRFPFSID---QEGDIYVTQPLDREEKDAYVFYAVAKDEYGK 318
P A Y ++ + F D EG + V + +D E A++ + ++
Sbjct: 421 PHSPNWNAVYRIISGDPSGHFSVRTDPVTNEGMVTVVKAVDYELNRAFMLTVMVSNQ--A 478
Query: 319 PLSYPLE--------IHVKVKDINDNPPTCPSPVTVFEVQENERLGNSIGTLTAHDRDEE 370
PL+ ++ + + + DIN+ P PS + ++E G + T +A D D
Sbjct: 479 PLASGIQMSFQSTAGVTISIMDINE-APYFPSNHKLIRLEEGVPPGTVLTTFSAVDPDR- 536
Query: 371 NTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLA---KQSLKKQDTPQYNLTIEVSDK 427
F+ + P L + T + A ++SL ++ Y T +D
Sbjct: 537 -----FMQQAVRYSKLSDPASWLHINATNGQITTAAVLDRESLYTKNN-VYEATFLAADN 590
Query: 428 DFKTLC---FVQINVIDINDQIP--------IFEKSDYG--NLTLAE---DTNIGSTILT 471
+QI +IDIND P I EK + N+T A+ D NIG +
Sbjct: 591 GIPPASGTGTLQIYLIDINDNAPELLPKEAQICEKPNLNAINITAADADVDPNIGPYVFE 650
Query: 472 I 472
+
Sbjct: 651 L 651
>gi|14589889 cadherin 2, type 1 preproprotein [Homo sapiens]
Length = 906
Score = 255 bits (652), Expect = 1e-67
Identities = 186/613 (30%), Positives = 285/613 (46%), Gaps = 33/613 (5%)
Query: 239 WKAPKPVEMVENSTDPHPIKITQVRWN---DPGAQYSLVDK--EKLPRFPFSIDQ-EGDI 292
W P P+ + ENS P P ++ ++R + + +YS+ ++ P F I+ G +
Sbjct: 161 WVIP-PINLPENSRGPFPQELVRIRSDRDKNLSLRYSVTGPGADQPPTGIFIINPISGQL 219
Query: 293 YVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQEN 352
VT+PLDRE+ + A A D G + P++I + V D+NDN P V V E
Sbjct: 220 SVTKPLDREQIARFHLRAHAVDINGNQVENPIDIVINVIDMNDNRPEFLHQVWNGTVPEG 279
Query: 353 ERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKK 412
+ G + T+TA D D+ N N L YRIV Q P P +F I G + L +
Sbjct: 280 SKPGTYVMTVTAIDADDPNALNGMLRYRIVSQAPSTPSPNMFTINNETGDIITVAAGLDR 339
Query: 413 QDTPQYNLTIEVSDKD------FKTLCFVQINVIDINDQIPIFEKSD-YGNLTLAEDTNI 465
+ QY L I+ +D + I V D+ND P F YG + + +
Sbjct: 340 EKVQQYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGEVP---ENRV 396
Query: 466 GSTILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAA 525
+ + TD D+P T + +Y I GD GR + TDP++N G V + KP+DFET
Sbjct: 397 DIIVANLTVTDKDQPHTPAWNAVYRISGGDPTGRFAIQTDPNSNDGLVTVVKPIDFETNR 456
Query: 526 VSNIVFKAENPEPLVFGVKYNASSFAKFTLIVTDVNEAPQFSQHVFQAKVSEDVAIGTKV 585
+ + AEN PL G+++ S A ++ V DVNE P F+ + + E + GT +
Sbjct: 457 MFVLTVAAENQVPLAKGIQHPPQSTATVSVTVIDVNENPYFAPNPKIIRQEEGLHAGTML 516
Query: 586 GNVTAKDPEGL---DISYSLRGDTRGWLKIDHVTGEIFSVAPLDREA----GSPYRVQVV 638
TA+DP+ +I Y+ D WLKID V G+I ++A LDRE+ + Y +
Sbjct: 517 TTFTAQDPDRYMQQNIRYTKLSDPANWLKIDPVNGQITTIAVLDRESPNVKNNIYNATFL 576
Query: 639 ATEVGGSSLSSVSEFHLILMDVNDNPPRLAKDYTGLFFCHPLSAPGSLIFEATDDDQHLF 698
A++ G +S + L+D+NDN P++ C P S+ A D D
Sbjct: 577 ASDNGIPPMSGTGTLQIYLLDINDNAPQVLPQEAET--CE-TPDPNSINITALDYDIDPN 633
Query: 699 RGPH-FTFSLGSGSLQNDWEVSKINGTHARLSTRHTEFEEREYVVLIRINDGGRPPLEGI 757
GP F L +++ +W ++++NG A+L+ + E Y V I I D G PP I
Sbjct: 634 AGPFAFDLPLSPVTIKRNWTITRLNGDFAQLNLKIKFLEAGIYEVPIIITDSGNPPKSNI 693
Query: 758 VSLPVTFCSC-VEGSCFRPAGHQTGIPTVGMAVGILLTTLLVIGIILAVVFIRIKKDKGK 816
L V C C G C I G+ G ++ LL I I+L +V + + K +
Sbjct: 694 SILRVKVCQCDSNGDC----TDVDRIVGAGLGTGAIIAILLCIIILLILVLMFVVWMKRR 749
Query: 817 DNVESAQASEVKP 829
D A+ + P
Sbjct: 750 DKERQAKQLLIDP 762
Score = 142 bits (359), Expect = 1e-33
Identities = 123/404 (30%), Positives = 181/404 (44%), Gaps = 34/404 (8%)
Query: 69 IFVIER-EGLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNRPTFL 127
IF+I G L + LDRE + +L+ A+D NG VE P+ I I V D+NDNRP FL
Sbjct: 209 IFIINPISGQLSVTKPLDREQIARFHLRAHAVDINGNQVENPIDIVINVIDMNDNRPEFL 268
Query: 128 QSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQINNKTG 187
+ G+V + S+PG + V A D DDP NG L Y+IV Q P + F INN+TG
Sbjct: 269 HQVWNGTVPEGSKPGTYVMTVTAIDADDPNALNGMLRYRIVSQAPSTPSPNMFTINNETG 328
Query: 188 AISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTENIWKAPKPV-- 245
I G L+ K Y L+I DM G S+T + I VT+ P+
Sbjct: 329 DIITVAAG---LDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAM 385
Query: 246 ----EMVENSTDPHPIKITQVRWNDP-----GAQYSLVDKEKLPRFPFSID---QEGDIY 293
E+ EN D +T + P A Y + + RF D +G +
Sbjct: 386 TFYGEVPENRVDIIVANLTVTDKDQPHTPAWNAVYRISGGDPTGRFAIQTDPNSNDGLVT 445
Query: 294 VTQPLDREEKDAYVFYAVAKDE--YGKPLSYPLE----IHVKVKDINDNPPTCPSPVTVF 347
V +P+D E +V A+++ K + +P + + V V D+N+NP P+P +
Sbjct: 446 VVKPIDFETNRMFVLTVAAENQVPLAKGIQHPPQSTATVSVTVIDVNENPYFAPNP-KII 504
Query: 348 EVQENERLGNSIGTLTAHDRDEENTANSFLNY-RIVEQTPKLPMDGLFLIQTYAGMLQLA 406
+E G + T TA D D N + Y ++ + L +D + T +L
Sbjct: 505 RQEEGLHAGTMLTTFTAQDPDRYMQQN--IRYTKLSDPANWLKIDPVNGQITTIAVLDRE 562
Query: 407 KQSLKKQDTPQYNLTIEVSDKDFKTLC---FVQINVIDINDQIP 447
++K YN T SD + +QI ++DIND P
Sbjct: 563 SPNVKNN---IYNATFLASDNGIPPMSGTGTLQIYLLDINDNAP 603
>gi|148539848 desmocollin 3 isoform Dsc3b preproprotein [Homo
sapiens]
Length = 839
Score = 246 bits (629), Expect = 5e-65
Identities = 182/601 (30%), Positives = 286/601 (47%), Gaps = 42/601 (6%)
Query: 241 APKPVEMVENSTDPHPIKITQVRWNDPGAQYSL--------VDKEKLPRFPFSIDQEGDI 292
AP P M ENS P P+ + QV +D Y++ VDKE L F D G++
Sbjct: 138 APIPCSMQENSLGPFPLFLQQVE-SDAAQNYTVFYSISGRGVDKEPLNLFYIERDT-GNL 195
Query: 293 YVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQEN 352
+ T+P+DREE D + A A G PL + ++V+D NDN P + FEV E+
Sbjct: 196 FCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEAIYNFEVLES 255
Query: 353 ERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKK 412
R G ++G + A DRDE +T ++ L Y I++QTP+ P GLF + G++ L +
Sbjct: 256 SRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSP--GLFSVHPSTGVITTVSHYLDR 313
Query: 413 QDTPQYNLTIEVSDKDFKTLCFVQ-----INVIDINDQIPIFEKSDYGNLTLAEDTNIGS 467
+ +Y+L ++V D D + + I V D ND P F ++ Y E+
Sbjct: 314 EVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYE--AFVEENAFNV 371
Query: 468 TILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVS 527
IL I D D T + ++ + I+KG+ G + TD TN G + + KPL++E
Sbjct: 372 EILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYEENRQV 431
Query: 528 NIVFKAENPEPLVFGV-KYNASSFAKFTLIVTDVNEAPQFSQHVFQAKVSEDVAIGTKVG 586
N+ N P + + A + A T+ V D++E P+ + ++ E++A+G+K+
Sbjct: 432 NLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSKIN 491
Query: 587 NVTAKDPE---GLDISYSLRGDTRGWLKIDHVTGEIFSVAPLDREAGSP----YRVQVVA 639
A DPE G + Y D +GW+ ID ++G I + LDRE +P Y + V+A
Sbjct: 492 GYKAYDPENRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETPKNELYNITVLA 551
Query: 640 TEVGGSSLSSVSEFHLILMDVNDNPPRLAKDYTGLFFCHPLSAPGSLIFEATDDDQHLFR 699
+ S + + + DVNDNPP + ++Y + C P ++ D+ H
Sbjct: 552 IDKDDRSCTGTLAVN--IEDVNDNPPEILQEY--VVICKPKMGYTDILAVDPDEPVH--- 604
Query: 700 GPHFTFSLGSGS--LQNDWEVSKINGTHARLS-TRHTEFEEREYVVLIRINDGGRPPLEG 756
G F FSL + S + W ++K+N T ARLS ++ F+ EY + I + D R
Sbjct: 605 GAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQ--EYTIPITVKD--RAGQAA 660
Query: 757 IVSLPVTFCSCVEGSCFRPAGHQTGIPTVGMAV-GILLTTLLVIGIILAVVFIRIKKDKG 815
L V C C + R TG+ A+ ILL L+ ++L +V KG
Sbjct: 661 TKLLRVNLCECTHPTQCRATSRSTGVILGKWAILAILLGIALLFSVLLTLVCGVFGATKG 720
Query: 816 K 816
K
Sbjct: 721 K 721
Score = 117 bits (294), Expect = 3e-26
Identities = 122/446 (27%), Positives = 202/446 (45%), Gaps = 52/446 (11%)
Query: 68 NIFVIERE-GLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNRPTF 126
N+F IER+ G L+ R +DRE +L A A+G + P+P+ I+V+D NDN P F
Sbjct: 184 NLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVF 243
Query: 127 LQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQINNKT 186
++ Y V ++SRPG V ATD D+P T + +L Y I+ Q P + F ++ T
Sbjct: 244 TEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGL--FSVHPST 301
Query: 187 GAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTENIWKAPK--- 243
G I+ S L+ Y+L++ V+DM GQ +T + I VT++ AP
Sbjct: 302 GVITTV---SHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCI-ITVTDSNDNAPTFRQ 357
Query: 244 ---PVEMVENSTDPHPIK--------ITQVRWNDPGAQYSLVDKEKLPRFPFSIDQ---E 289
+ EN+ + ++ I W ++++ + F S D+ E
Sbjct: 358 NAYEAFVEENAFNVEILRIPIEDKDLINTANWR---VNFTILKGNENGHFKISTDKETNE 414
Query: 290 GDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYP-------LEIHVKVKDINDNPPTCPS 342
G + V +PL+ EE +E P + V V+D+++ P P+
Sbjct: 415 GVLSVVKPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPA 474
Query: 343 PVTVFEVQENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGM 402
V ++EN +G+ I A+ D EN + L Y+ + PK G I +G
Sbjct: 475 AQYV-RIKENLAVGSKINGYKAY--DPENRNGNGLRYKKLHD-PK----GWITIDEISGS 526
Query: 403 LQLAKQSLKKQDTPQ---YNLTIEVSDKDFKTLC-FVQINVIDINDQIPIFEKSDYGNLT 458
+ +K ++ +TP+ YN+T+ DKD ++ + +N+ D+ND P +
Sbjct: 527 IITSKILDREVETPKNELYNITVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQ----EYV 582
Query: 459 LAEDTNIGSTILTIQATDADEPFTGS 484
+ +G T I A D DEP G+
Sbjct: 583 VICKPKMGYT--DILAVDPDEPVHGA 606
>gi|148539846 desmocollin 3 isoform Dsc3a preproprotein [Homo
sapiens]
Length = 896
Score = 246 bits (629), Expect = 5e-65
Identities = 182/601 (30%), Positives = 286/601 (47%), Gaps = 42/601 (6%)
Query: 241 APKPVEMVENSTDPHPIKITQVRWNDPGAQYSL--------VDKEKLPRFPFSIDQEGDI 292
AP P M ENS P P+ + QV +D Y++ VDKE L F D G++
Sbjct: 138 APIPCSMQENSLGPFPLFLQQVE-SDAAQNYTVFYSISGRGVDKEPLNLFYIERDT-GNL 195
Query: 293 YVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQEN 352
+ T+P+DREE D + A A G PL + ++V+D NDN P + FEV E+
Sbjct: 196 FCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEAIYNFEVLES 255
Query: 353 ERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKK 412
R G ++G + A DRDE +T ++ L Y I++QTP+ P GLF + G++ L +
Sbjct: 256 SRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSP--GLFSVHPSTGVITTVSHYLDR 313
Query: 413 QDTPQYNLTIEVSDKDFKTLCFVQ-----INVIDINDQIPIFEKSDYGNLTLAEDTNIGS 467
+ +Y+L ++V D D + + I V D ND P F ++ Y E+
Sbjct: 314 EVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYE--AFVEENAFNV 371
Query: 468 TILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVS 527
IL I D D T + ++ + I+KG+ G + TD TN G + + KPL++E
Sbjct: 372 EILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYEENRQV 431
Query: 528 NIVFKAENPEPLVFGV-KYNASSFAKFTLIVTDVNEAPQFSQHVFQAKVSEDVAIGTKVG 586
N+ N P + + A + A T+ V D++E P+ + ++ E++A+G+K+
Sbjct: 432 NLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSKIN 491
Query: 587 NVTAKDPE---GLDISYSLRGDTRGWLKIDHVTGEIFSVAPLDREAGSP----YRVQVVA 639
A DPE G + Y D +GW+ ID ++G I + LDRE +P Y + V+A
Sbjct: 492 GYKAYDPENRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETPKNELYNITVLA 551
Query: 640 TEVGGSSLSSVSEFHLILMDVNDNPPRLAKDYTGLFFCHPLSAPGSLIFEATDDDQHLFR 699
+ S + + + DVNDNPP + ++Y + C P ++ D+ H
Sbjct: 552 IDKDDRSCTGTLAVN--IEDVNDNPPEILQEY--VVICKPKMGYTDILAVDPDEPVH--- 604
Query: 700 GPHFTFSLGSGS--LQNDWEVSKINGTHARLS-TRHTEFEEREYVVLIRINDGGRPPLEG 756
G F FSL + S + W ++K+N T ARLS ++ F+ EY + I + D R
Sbjct: 605 GAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQ--EYTIPITVKD--RAGQAA 660
Query: 757 IVSLPVTFCSCVEGSCFRPAGHQTGIPTVGMAV-GILLTTLLVIGIILAVVFIRIKKDKG 815
L V C C + R TG+ A+ ILL L+ ++L +V KG
Sbjct: 661 TKLLRVNLCECTHPTQCRATSRSTGVILGKWAILAILLGIALLFSVLLTLVCGVFGATKG 720
Query: 816 K 816
K
Sbjct: 721 K 721
Score = 117 bits (294), Expect = 3e-26
Identities = 122/446 (27%), Positives = 202/446 (45%), Gaps = 52/446 (11%)
Query: 68 NIFVIERE-GLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNRPTF 126
N+F IER+ G L+ R +DRE +L A A+G + P+P+ I+V+D NDN P F
Sbjct: 184 NLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVF 243
Query: 127 LQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQINNKT 186
++ Y V ++SRPG V ATD D+P T + +L Y I+ Q P + F ++ T
Sbjct: 244 TEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGL--FSVHPST 301
Query: 187 GAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTENIWKAPK--- 243
G I+ S L+ Y+L++ V+DM GQ +T + I VT++ AP
Sbjct: 302 GVITTV---SHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCI-ITVTDSNDNAPTFRQ 357
Query: 244 ---PVEMVENSTDPHPIK--------ITQVRWNDPGAQYSLVDKEKLPRFPFSIDQ---E 289
+ EN+ + ++ I W ++++ + F S D+ E
Sbjct: 358 NAYEAFVEENAFNVEILRIPIEDKDLINTANWR---VNFTILKGNENGHFKISTDKETNE 414
Query: 290 GDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYP-------LEIHVKVKDINDNPPTCPS 342
G + V +PL+ EE +E P + V V+D+++ P P+
Sbjct: 415 GVLSVVKPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPA 474
Query: 343 PVTVFEVQENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGM 402
V ++EN +G+ I A+ D EN + L Y+ + PK G I +G
Sbjct: 475 AQYV-RIKENLAVGSKINGYKAY--DPENRNGNGLRYKKLHD-PK----GWITIDEISGS 526
Query: 403 LQLAKQSLKKQDTPQ---YNLTIEVSDKDFKTLC-FVQINVIDINDQIPIFEKSDYGNLT 458
+ +K ++ +TP+ YN+T+ DKD ++ + +N+ D+ND P +
Sbjct: 527 IITSKILDREVETPKNELYNITVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQ----EYV 582
Query: 459 LAEDTNIGSTILTIQATDADEPFTGS 484
+ +G T I A D DEP G+
Sbjct: 583 VICKPKMGYT--DILAVDPDEPVHGA 606
>gi|13435366 desmocollin 2 isoform Dsc2b preproprotein [Homo
sapiens]
Length = 847
Score = 243 bits (621), Expect = 4e-64
Identities = 182/592 (30%), Positives = 285/592 (48%), Gaps = 42/592 (7%)
Query: 241 APKPVEMVENSTDPHPIKITQVRWNDPGAQYSL--------VDKEKLPRFPFSIDQE-GD 291
AP P M+ENS P P+ + QV+ +D Y++ VD+E PR F ++++ G+
Sbjct: 138 APIPCSMLENSLGPFPLFLQQVQ-SDTAQNYTIYYSIRGPGVDQE--PRNLFYVERDTGN 194
Query: 292 IYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQE 351
+Y T+P+DRE+ +++ A A G PL + +K++D NDN P F + E
Sbjct: 195 LYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNYPIFTEETYTFTIFE 254
Query: 352 NERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLK 411
N R+G ++G + A D+DE +T ++ L Y I+ Q P P LF + G++ L
Sbjct: 255 NCRVGTTVGQVCATDKDEPDTMHTRLKYSIIGQVP--PSPTLFSMHPTTGVITTTSSQLD 312
Query: 412 KQDTPQYNLTIEVSDKD-----FKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIG 466
++ +Y L I+V D D +T IN+ D+ND +P F ++ Y +T E+ +
Sbjct: 313 RELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSY--VTSVEENTVD 370
Query: 467 STILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAV 526
IL + D D T + + Y I+KG+ G + TD TN G + + KPL++E
Sbjct: 371 VEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKPLNYEEKQQ 430
Query: 527 SNIVFKAENPEPLVFGVK-YNASSFAKFTLIVTDVNEAPQFSQHVFQAKVSEDVAIGTKV 585
+ N P +A S A T+ V D +E P+ + + ++ E+ +GT
Sbjct: 431 MILQIGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENAEVGTTS 490
Query: 586 GNVTAKDPE---GLDISYSLRGDTRGWLKIDHVTGEIFSVAPLDREA----GSPYRVQVV 638
A DPE I Y D GW+ ID TG I LDREA Y + V+
Sbjct: 491 NGYKAYDPETRSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLDREAETIKNGIYNITVL 550
Query: 639 ATEVGGSSLSSVSEFHLILMDVNDNPPRLAKDYTGLFFCHPLSAPGSLIFEATDDDQHLF 698
A++ GG + + +IL DVNDN P + K + C P + ++ A D D+ +
Sbjct: 551 ASDQGGRTCTGT--LGIILQDVNDNSPFIPK--KTVIICKPTMSSAEIV--AVDPDEPI- 603
Query: 699 RGPHFTFSLGSGS--LQNDWEVSKINGTHARLSTRHTEFEEREYVVLIRINDGGRPPLEG 756
GP F FSL S + +Q W + IN T ARLS ++ + YVV I + D R +
Sbjct: 604 HGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQN-DPPFGSYVVPITVRD--RLGMSS 660
Query: 757 IVSLPVTFCSCV-EGSCFRPAGHQTGIPTVGMAVGILLTTLLVIGIILAVVF 807
+ SL VT C C+ E C + G V + +L LL I ++ ++F
Sbjct: 661 VTSLDVTLCDCITENDCTHRVDPRIGGGGVQLGKWAILAILLGIALLFCILF 712
Score = 120 bits (302), Expect = 4e-27
Identities = 118/447 (26%), Positives = 200/447 (44%), Gaps = 50/447 (11%)
Query: 65 ETDNIFVIERE-GLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNR 123
E N+F +ER+ G LY R +DRE + + A +G E P+P+ IK++D NDN
Sbjct: 181 EPRNLFYVERDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNY 240
Query: 124 PTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQIN 183
P F + Y ++ +N R G V ATD D+P T + +L Y I+ Q+P + F ++
Sbjct: 241 PIFTEETYTFTIFENCRVGTTVGQVCATDKDEPDTMHTRLKYSIIGQVP--PSPTLFSMH 298
Query: 184 NKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTENI----- 238
TG I+ T S +L+ Y L I V+DM GQ TTS II +++
Sbjct: 299 PTTGVITTT---SSQLDRELIDKYQLKIKVQDMDGQYFG--LQTTSTCIINIDDVNDHLP 353
Query: 239 --WKAPKPVEMVENSTDPHPIKIT-----QVRWNDPGAQYSLVDKEKLPRFPFSID---Q 288
+ + EN+ D +++T V + A Y+++ + F D
Sbjct: 354 TFTRTSYVTSVEENTVDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTN 413
Query: 289 EGDIYVTQPLDREEKDAYVFY-------AVAKDEYGKPLSYPLEIHVKVKDINDNPPTCP 341
EG + V +PL+ EEK + +++ + + V V+D D P C
Sbjct: 414 EGVLCVVKPLNYEEKQQMILQIGVVNEAPFSREASPRSAMSTATVTVNVED-QDEGPECN 472
Query: 342 SPVTVFEVQENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAG 401
P+ ++EN +G + A+ D E ++S + Y+ + G I G
Sbjct: 473 PPIQTVRMKENAEVGTTSNGYKAY--DPETRSSSGIRYKKLTDP-----TGWVTIDENTG 525
Query: 402 MLQLAKQSLKKQDTPQ---YNLTIEVSDKDFKTLCFVQINVI--DINDQIPIFEKSDYGN 456
+++ + ++ +T + YN+T+ SD+ +T C + +I D+ND P K
Sbjct: 526 SIKVFRSLDREAETIKNGIYNITVLASDQGGRT-CTGTLGIILQDVNDNSPFIPKK---T 581
Query: 457 LTLAEDTNIGSTILTIQATDADEPFTG 483
+ + + T + I+ A D DEP G
Sbjct: 582 VIICKPTMSSAEIV---AVDPDEPIHG 605
>gi|13435364 desmocollin 2 isoform Dsc2a preproprotein [Homo
sapiens]
Length = 901
Score = 243 bits (621), Expect = 4e-64
Identities = 182/592 (30%), Positives = 285/592 (48%), Gaps = 42/592 (7%)
Query: 241 APKPVEMVENSTDPHPIKITQVRWNDPGAQYSL--------VDKEKLPRFPFSIDQE-GD 291
AP P M+ENS P P+ + QV+ +D Y++ VD+E PR F ++++ G+
Sbjct: 138 APIPCSMLENSLGPFPLFLQQVQ-SDTAQNYTIYYSIRGPGVDQE--PRNLFYVERDTGN 194
Query: 292 IYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQE 351
+Y T+P+DRE+ +++ A A G PL + +K++D NDN P F + E
Sbjct: 195 LYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNYPIFTEETYTFTIFE 254
Query: 352 NERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLK 411
N R+G ++G + A D+DE +T ++ L Y I+ Q P P LF + G++ L
Sbjct: 255 NCRVGTTVGQVCATDKDEPDTMHTRLKYSIIGQVP--PSPTLFSMHPTTGVITTTSSQLD 312
Query: 412 KQDTPQYNLTIEVSDKD-----FKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIG 466
++ +Y L I+V D D +T IN+ D+ND +P F ++ Y +T E+ +
Sbjct: 313 RELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSY--VTSVEENTVD 370
Query: 467 STILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAV 526
IL + D D T + + Y I+KG+ G + TD TN G + + KPL++E
Sbjct: 371 VEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKPLNYEEKQQ 430
Query: 527 SNIVFKAENPEPLVFGVK-YNASSFAKFTLIVTDVNEAPQFSQHVFQAKVSEDVAIGTKV 585
+ N P +A S A T+ V D +E P+ + + ++ E+ +GT
Sbjct: 431 MILQIGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENAEVGTTS 490
Query: 586 GNVTAKDPE---GLDISYSLRGDTRGWLKIDHVTGEIFSVAPLDREA----GSPYRVQVV 638
A DPE I Y D GW+ ID TG I LDREA Y + V+
Sbjct: 491 NGYKAYDPETRSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLDREAETIKNGIYNITVL 550
Query: 639 ATEVGGSSLSSVSEFHLILMDVNDNPPRLAKDYTGLFFCHPLSAPGSLIFEATDDDQHLF 698
A++ GG + + +IL DVNDN P + K + C P + ++ A D D+ +
Sbjct: 551 ASDQGGRTCTGT--LGIILQDVNDNSPFIPK--KTVIICKPTMSSAEIV--AVDPDEPI- 603
Query: 699 RGPHFTFSLGSGS--LQNDWEVSKINGTHARLSTRHTEFEEREYVVLIRINDGGRPPLEG 756
GP F FSL S + +Q W + IN T ARLS ++ + YVV I + D R +
Sbjct: 604 HGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQN-DPPFGSYVVPITVRD--RLGMSS 660
Query: 757 IVSLPVTFCSCV-EGSCFRPAGHQTGIPTVGMAVGILLTTLLVIGIILAVVF 807
+ SL VT C C+ E C + G V + +L LL I ++ ++F
Sbjct: 661 VTSLDVTLCDCITENDCTHRVDPRIGGGGVQLGKWAILAILLGIALLFCILF 712
Score = 120 bits (302), Expect = 4e-27
Identities = 118/447 (26%), Positives = 200/447 (44%), Gaps = 50/447 (11%)
Query: 65 ETDNIFVIERE-GLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNR 123
E N+F +ER+ G LY R +DRE + + A +G E P+P+ IK++D NDN
Sbjct: 181 EPRNLFYVERDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNY 240
Query: 124 PTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQIN 183
P F + Y ++ +N R G V ATD D+P T + +L Y I+ Q+P + F ++
Sbjct: 241 PIFTEETYTFTIFENCRVGTTVGQVCATDKDEPDTMHTRLKYSIIGQVP--PSPTLFSMH 298
Query: 184 NKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTENI----- 238
TG I+ T S +L+ Y L I V+DM GQ TTS II +++
Sbjct: 299 PTTGVITTT---SSQLDRELIDKYQLKIKVQDMDGQYFG--LQTTSTCIINIDDVNDHLP 353
Query: 239 --WKAPKPVEMVENSTDPHPIKIT-----QVRWNDPGAQYSLVDKEKLPRFPFSID---Q 288
+ + EN+ D +++T V + A Y+++ + F D
Sbjct: 354 TFTRTSYVTSVEENTVDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTN 413
Query: 289 EGDIYVTQPLDREEKDAYVFY-------AVAKDEYGKPLSYPLEIHVKVKDINDNPPTCP 341
EG + V +PL+ EEK + +++ + + V V+D D P C
Sbjct: 414 EGVLCVVKPLNYEEKQQMILQIGVVNEAPFSREASPRSAMSTATVTVNVED-QDEGPECN 472
Query: 342 SPVTVFEVQENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAG 401
P+ ++EN +G + A+ D E ++S + Y+ + G I G
Sbjct: 473 PPIQTVRMKENAEVGTTSNGYKAY--DPETRSSSGIRYKKLTDP-----TGWVTIDENTG 525
Query: 402 MLQLAKQSLKKQDTPQ---YNLTIEVSDKDFKTLCFVQINVI--DINDQIPIFEKSDYGN 456
+++ + ++ +T + YN+T+ SD+ +T C + +I D+ND P K
Sbjct: 526 SIKVFRSLDREAETIKNGIYNITVLASDQGGRT-CTGTLGIILQDVNDNSPFIPKK---T 581
Query: 457 LTLAEDTNIGSTILTIQATDADEPFTG 483
+ + + T + I+ A D DEP G
Sbjct: 582 VIICKPTMSSAEIV---AVDPDEPIHG 605
>gi|4502719 cadherin 13 preproprotein [Homo sapiens]
Length = 713
Score = 238 bits (606), Expect = 2e-62
Identities = 188/626 (30%), Positives = 289/626 (46%), Gaps = 52/626 (8%)
Query: 179 YFQINNKTGAISL---TREGSQELNPAKNPSYN-----LVISVKDMGGQSEN--SFSDTT 228
YF++N+ G ++L T G A+ P +++ KD+ G ++ F+ T+
Sbjct: 72 YFKVNSDGGLVALRNITAVGKTLFVHARTPHAEDMAELVIVGGKDIQGSLQDIFKFARTS 131
Query: 229 SV-----DIIVTENIWKAPKPVEMVENSTDPHPIKITQVRWND--PGAQYSLVDK--EKL 279
V I+V+ P+ + EN P P + +V +D +++ L K ++
Sbjct: 132 PVPRQKRSIVVS--------PILIPENQRQPFPRDVGKVVDSDRPERSKFRLTGKGVDQE 183
Query: 280 PRFPFSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPP 338
P+ F I++ G + VT+ LDRE Y + D GK L P+ + V V D NDN P
Sbjct: 184 PKGIFRINENTGSVSVTRTLDREVIAVYQLFVETTDVNGKTLEGPVPLEVIVIDQNDNRP 243
Query: 339 TCPSPVTVFEVQENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQT 398
+ V E G ++ +TA D D+ T N+ L Y I +QTP P +F I
Sbjct: 244 IFREGPYIGHVMEGSPTGTTVMRMTAFDADDPATDNALLRYNIRQQTPDKPSPNMFYIDP 303
Query: 399 YAG-MLQLAKQSLKKQDT---PQYNLTIEVSDK-----DFKTLCFVQINVIDINDQIPIF 449
G ++ + +L ++T P+Y L IE D I + D ND P F
Sbjct: 304 EKGDIVTVVSPALLDRETLENPKYELIIEAQDMAGLDVGLTGTATATIMIDDKNDHSPKF 363
Query: 450 EKSDYGNLTLAEDTNIGSTILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTN 509
K ++ E+ +G I+ + D D+P TG+ + Y II G+ + T+P TN
Sbjct: 364 TKKEFQ--ATVEEGAVG-VIVNLTVEDKDDPTTGAWRAAYTIINGNPGQSFEIHTNPQTN 420
Query: 510 TGYVIIKKPLDFETAAVSNIVFKAENPEPLVFGVKYNASSFAKFTLIVTDVNEAPQFSQH 569
G + + KPLD+E +A ++ K EN +PLV V Y SS A + V DVNE P F
Sbjct: 421 EGMLSVVKPLDYEISAFHTLLIKVENEDPLVPDVSYGPSSTATVHITVLDVNEGPVFYPD 480
Query: 570 VFQAKVSEDVAIGTKVGNVTAKDPEGLD---ISYSLRGDTRGWLKIDHVTGEIFSVAPLD 626
ED+++G+ + V A DP+ L I YS+ D GWL I+ + G + + A LD
Sbjct: 481 PMMVTRQEDLSVGSVLLTVNATDPDSLQHQTIRYSVYKDPAGWLNINPINGTVDTTAVLD 540
Query: 627 REA----GSPYRVQVVATEVGGSSLSSVSEFHLILMDVNDNPPRLAKDYTGLFFCHPLSA 682
RE+ S Y +A + G + + L DVNDN P + T C
Sbjct: 541 RESPFVDNSVYTALFLAIDSGNPPATGTGTLLITLEDVNDNAPFIYP--TVAEVCDDAKN 598
Query: 683 PGSLIFEATDDDQHLFRGPHFTFSLGSGSLQND-WEVSKINGTHARLSTRHTEFEEREYV 741
+I A+D D H P F F + ++ + W++SKIN THA +S + Y
Sbjct: 599 LSVVILGASDKDLHPNTDP-FKFEIHKQAVPDKVWKISKINNTHALVSLLQ-NLNKANYN 656
Query: 742 VLIRINDGGRPPLEGIVSLPVTFCSC 767
+ I + D G+PP+ I L V CSC
Sbjct: 657 LPIMVTDSGKPPMTNITDLRVQVCSC 682
Score = 116 bits (290), Expect = 1e-25
Identities = 101/342 (29%), Positives = 152/342 (44%), Gaps = 32/342 (9%)
Query: 55 PPAVTFELTG-----ETDNIFVI-EREGLLYYNRALDRETRSTHNLQVAALDANGIIVEG 108
P F LTG E IF I E G + R LDRE + + L V D NG +EG
Sbjct: 168 PERSKFRLTGKGVDQEPKGIFRINENTGSVSVTRTLDREVIAVYQLFVETTDVNGKTLEG 227
Query: 109 PVPITIKVKDINDNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIV 168
PVP+ + V D NDNRP F + Y G V + S G + + A D DDPAT N L Y I
Sbjct: 228 PVPLEVIVIDQNDNRPIFREGPYIGHVMEGSPTGTTVMRMTAFDADDPATDNALLRYNIR 287
Query: 169 IQLPMINNVMYFQINNKTG-AISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDT 227
Q P + F I+ + G +++ + +NP Y L+I +DM G + + T
Sbjct: 288 QQTPDKPSPNMFYIDPEKGDIVTVVSPALLDRETLENPKYELIIEAQDMAG-LDVGLTGT 346
Query: 228 TSVDIIVTENIWKAPKPVE-----MVENSTDPHPIKITQVRWNDP-----GAQYSLVDKE 277
+ I++ + +PK + VE + +T +DP A Y++++
Sbjct: 347 ATATIMIDDKNDHSPKFTKKEFQATVEEGAVGVIVNLTVEDKDDPTTGAWRAAYTIINGN 406
Query: 278 KLPRFPFSID---QEGDIYVTQPLDREEKDAYVFYAVAKDE--------YGKPLSYPLEI 326
F + EG + V +PLD E + ++E YG S +
Sbjct: 407 PGQSFEIHTNPQTNEGMLSVVKPLDYEISAFHTLLIKVENEDPLVPDVSYGP--SSTATV 464
Query: 327 HVKVKDINDNPPTCPSPVTVFEVQENERLGNSIGTLTAHDRD 368
H+ V D+N+ P P P+ V QE+ +G+ + T+ A D D
Sbjct: 465 HITVLDVNEGPVFYPDPMMVTR-QEDLSVGSVLLTVNATDPD 505
Score = 30.0 bits (66), Expect = 9.2
Identities = 41/166 (24%), Positives = 64/166 (38%), Gaps = 21/166 (12%)
Query: 62 LTGETDNIFVIEREGLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDIND 121
+ G D V++RE N S + A+D+ G + I ++D+ND
Sbjct: 529 INGTVDTTAVLDRESPFVDN--------SVYTALFLAIDSGNPPATGTGTLLITLEDVND 580
Query: 122 NRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLY-YQIVIQLPMINNVMYF 180
N P + E + + + A+D D PN + ++I Q
Sbjct: 581 NAPFIYPTVAEVC---DDAKNLSVVILGASDKD--LHPNTDPFKFEIHKQAVPDKVWKIS 635
Query: 181 QINNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSD 226
+INN +SL Q LN A +YNL I V D G + +D
Sbjct: 636 KINNTHALVSLL----QNLNKA---NYNLPIMVTDSGKPPMTNITD 674
>gi|4826671 cadherin 18, type 2 preproprotein [Homo sapiens]
Length = 790
Score = 218 bits (556), Expect = 1e-56
Identities = 176/556 (31%), Positives = 262/556 (47%), Gaps = 48/556 (8%)
Query: 287 DQEGDIYVTQPLDREEKDAYVFYAVAKDEY-GKPLSYPLEIHVKVKDINDNPPTCPSPVT 345
D GDI+ T+ LDRE+K YV +A A D KPL E +KV+DINDN P
Sbjct: 105 DTTGDIHSTKSLDREQKTHYVLHAQAIDRRTNKPLEPESEFIIKVQDINDNAPKFTDGPY 164
Query: 346 VFEVQENERLGNSIGTLTAHDRDEENTANSF-LNYRIVEQTPKLPMDGLFLIQTYAGMLQ 404
+ V E +G S+ +TA D D+ NS + Y I++ P F + G+++
Sbjct: 165 IVTVPEMSDMGTSVLQVTATDADDPTYGNSARVVYSILQGQP------YFSVDPKTGVIR 218
Query: 405 LAKQSLKKQDTPQYNLTIEVSDK-----DFKTLCFVQINVIDINDQIPIFEKSDYGNLTL 459
A ++ ++ Y++ I+ D V I + D+ND P F + Y L +
Sbjct: 219 TALHNMDREAREHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDNPPRFPQKHY-QLYV 277
Query: 460 AEDTNIGSTILTIQATDADEPFTGSSK-ILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKP 518
E +GS + I+A DAD TGS+ + Y II GD G + TD T G + +KKP
Sbjct: 278 PESAQVGSAVGKIKANDAD---TGSNADMTYSIINGDGMGIFSISTDKETREGILSLKKP 334
Query: 519 LDFETAAVSNIVFKAENPEPLVFGVKYNASSFAKFT------LIVTDVNEAPQFSQHVFQ 572
L++E + + N + + S F +IV DV+E P FS +
Sbjct: 335 LNYEKKKSYTLNIEGANTH-----LDFRFSHLGPFKDATMLKIIVGDVDEPPLFSMPSYL 389
Query: 573 AKVSEDVAIGTKVGNVTAKDPEGLD------ISYSLRGDTRGWLKIDHVTGEIFSVAPLD 626
+V E+ IGT VG V A+DP+ + I+Y++ D + ID TG I + LD
Sbjct: 390 MEVYENAKIGTVVGTVLAQDPDSTNSLVRYFINYNVEDDR--FFNIDANTGTIRTTKVLD 447
Query: 627 REAGSPYRVQVVATEVGGSSLSSVSEFHLILMDVNDNPPRLAKDYTGLFFCHPLSAPGSL 686
RE Y + V A+E+ L S + ++DVNDNPP LA++Y + C S PG +
Sbjct: 448 REETPWYNITVTASEIDNPDLLSHVTVGIRVLDVNDNPPELAREYD-IIVCEN-SKPGQV 505
Query: 687 I--FEATDDDQHLFRGPHFTFSLGSGSLQNDWEVSKINGTH-ARLSTRHTEFE---EREY 740
I ATD D GP F F L N K N + A + TR F + Y
Sbjct: 506 IHTISATDKDDFA-NGPRFNFFLDERLPVNPNFTLKDNEDNTASILTRRRRFSRTVQDVY 564
Query: 741 VVLIRINDGGRPPLEGIVSLPVTFCSCVEGSCFRPAGHQTGIPTVGMAVGILLTTLLVIG 800
+ I I+DGG P L +L + C+C R + + + G++ G L+ LL +
Sbjct: 565 YLPIMISDGGIPSLSSSSTLTIRVCACERDGRVRTCHAEAFLSSAGLSTGALIAILLCVL 624
Query: 801 IILAVV--FIRIKKDK 814
I+LA+V FI +++ K
Sbjct: 625 ILLAIVVLFITLRRSK 640
Score = 145 bits (367), Expect = 1e-34
Identities = 130/451 (28%), Positives = 213/451 (47%), Gaps = 49/451 (10%)
Query: 57 AVTFELTGE-TDNIFVIE-REGLLYYNRALDRETRSTHNLQVAALDAN-GIIVEGPVPIT 113
+V + LTGE IF+I+ G ++ ++LDRE ++ + L A+D +E
Sbjct: 87 SVKYILTGEGAGTIFIIDDTTGDIHSTKSLDREQKTHYVLHAQAIDRRTNKPLEPESEFI 146
Query: 114 IKVKDINDNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPN-GQLYYQIVIQLP 172
IKV+DINDN P F Y +V + S G L V ATD DDP N ++ Y I+ P
Sbjct: 147 IKVQDINDNAPKFTDGPYIVTVPEMSDMGTSVLQVTATDADDPTYGNSARVVYSILQGQP 206
Query: 173 MINNVMYFQINNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDI 232
YF ++ KTG I R ++ Y++VI KDM GQ S +T+V+I
Sbjct: 207 ------YFSVDPKTGVI---RTALHNMDREAREHYSVVIQAKDMAGQ-VGGLSGSTTVNI 256
Query: 233 IVTENIWKAP----KPVEMVENSTDPHPIKITQVRWNDPGA------QYSLVDKEKLPRF 282
+T+ P K ++ + + +++ ND YS+++ + + F
Sbjct: 257 TLTDVNDNPPRFPQKHYQLYVPESAQVGSAVGKIKANDADTGSNADMTYSIINGDGMGIF 316
Query: 283 PFSID---QEGDIYVTQPLDREEKDAYVF-------YAVAKDEYGKPLSYPLEIHVKVKD 332
S D +EG + + +PL+ E+K +Y + + + P + + V D
Sbjct: 317 SISTDKETREGILSLKKPLNYEKKKSYTLNIEGANTHLDFRFSHLGPFKDATMLKIIVGD 376
Query: 333 INDNPPTCPSPVTVFEVQENERLGNSIGTLTAHDRDEENT-ANSFLNYRIVEQTPKLPMD 391
+ D PP P + EV EN ++G +GT+ A D D N+ F+NY + + D
Sbjct: 377 V-DEPPLFSMPSYLMEVYENAKIGTVVGTVLAQDPDSTNSLVRYFINYNVED-------D 428
Query: 392 GLFLIQTYAGMLQLAKQSLKKQDTPQYNLTI---EVSDKDFKTLCFVQINVIDINDQIPI 448
F I G ++ K L +++TP YN+T+ E+ + D + V I V+D+ND P
Sbjct: 429 RFFNIDANTGTIRTTK-VLDREETPWYNITVTASEIDNPDLLSHVTVGIRVLDVNDNPP- 486
Query: 449 FEKSDYGNLTLAEDTNIGSTILTIQATDADE 479
E + ++ + E++ G I TI ATD D+
Sbjct: 487 -ELAREYDIIVCENSKPGQVIHTISATDKDD 516
Score = 42.4 bits (98), Expect = 0.002
Identities = 59/205 (28%), Positives = 88/205 (42%), Gaps = 16/205 (7%)
Query: 598 ISYSLRGDTRGWLKI-DHVTGEIFSVAPLDREAGSPYRVQVVATE-VGGSSLSSVSEFHL 655
+ Y L G+ G + I D TG+I S LDRE + Y + A + L SEF +
Sbjct: 88 VKYILTGEGAGTIFIIDDTTGDIHSTKSLDREQKTHYVLHAQAIDRRTNKPLEPESEFII 147
Query: 656 ILMDVNDNPPRLAKDYTGLFFCHPLSAPGSLIFE--ATD-DDQHLFRGPHFTFSLGSGSL 712
+ D+NDN P+ D + +S G+ + + ATD DD +S+ G
Sbjct: 148 KVQDINDNAPKFT-DGPYIVTVPEMSDMGTSVLQVTATDADDPTYGNSARVVYSILQG-- 204
Query: 713 QNDWEVSKINGTHARLSTRHTEFEERE-YVVLIRIND--GGRPPLEGIVSLPVTFCSCVE 769
Q + V G R + + + E RE Y V+I+ D G L G ++ +T +
Sbjct: 205 QPYFSVDPKTGV-IRTALHNMDREAREHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVND 263
Query: 770 GSCFRPAGH-QTGIP---TVGMAVG 790
P H Q +P VG AVG
Sbjct: 264 NPPRFPQKHYQLYVPESAQVGSAVG 288
>gi|4757960 cadherin 1, type 1 preproprotein [Homo sapiens]
Length = 882
Score = 212 bits (540), Expect = 1e-54
Identities = 180/595 (30%), Positives = 275/595 (46%), Gaps = 42/595 (7%)
Query: 239 WKAPKPVEMVENSTDPHPIKITQVRWN---DPGAQYSLVDK--EKLPRFPFSIDQE-GDI 292
W P P+ EN P P + Q++ N + YS+ + + P F I++E G +
Sbjct: 156 WVIP-PISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTPPVGVFIIERETGWL 214
Query: 293 YVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQEN 352
VT+PLDRE Y ++ A G + P+EI + V D NDN P V V E
Sbjct: 215 KVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEG 274
Query: 353 ERLGNSIGTLTAHDRDEE-NTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLK 411
G S+ +TA D D++ NT N+ + Y I+ Q P+LP +F I G++ + L
Sbjct: 275 ALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTGLD 334
Query: 412 KQDTPQYNLTIEVSD---KDFKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGST 468
++ P Y L ++ +D + T I V D ND PIF + Y + N+
Sbjct: 335 RESFPTYTLVVQAADLQGEGLSTTATAVITVTDTNDNPPIFNPTTYKGQVPENEANV--V 392
Query: 469 ILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVSN 528
I T++ TDAD P T + + +Y I+ D G+ V T+P N G + K LDFE
Sbjct: 393 ITTLKVTDADAPNTPAWEAVYTILNDDG-GQFVVTTNPVNNDGILKTAKGLDFEAKQQYI 451
Query: 529 IVFKAENPEPLVFGVKYNASSFAKFTLIVTDVNEAPQFSQHVFQAKVSEDVAIGTKVGNV 588
+ N P + +S A T+ V DVNEAP F + +VSED +G ++ +
Sbjct: 452 LHVAVTNVVPFEVSL---TTSTATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEITSY 508
Query: 589 TAKDPEGL---DISYSLRGDTRGWLKIDHVTGEIFSVAPLDRE-----AGSPYRVQVVAT 640
TA++P+ I+Y + DT WL+I+ TG I + A LDRE S Y ++AT
Sbjct: 509 TAQEPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNSTYTALIIAT 568
Query: 641 EVGGSSLSSVSEFHLILMDVNDNPPRLAKDYTGLFFCHPLSAPGSLIFEATDDDQHLFRG 700
+ G + LIL DVNDN P + +FFC P + D D
Sbjct: 569 DNGSPVATGTGTLLLILSDVNDNAP--IPEPRTIFFCE--RNPKPQVINIIDADLPPNTS 624
Query: 701 PHFTFSLGSGSLQNDWEVSKINGTHARLSTR-HTEFEEREYVVLIRINDGGRPPLEGIVS 759
P FT L G+ N W + + T + + E +Y + +++ D + + +
Sbjct: 625 P-FTAELTHGASAN-WTIQYNDPTQESIILKPKMALEVGDYKINLKLMDNQNK--DQVTT 680
Query: 760 LPVTFCSC--VEGSCFRPAGHQTG--IPTV-GMAVGILLTTLLVIGIILAVVFIR 809
L V+ C C G C + + G IP + G+ GIL L+I I+L ++F+R
Sbjct: 681 LEVSVCDCEGAAGVCRKAQPVEAGLQIPAILGILGGIL---ALLILILLLLLFLR 732
Score = 115 bits (287), Expect = 2e-25
Identities = 111/380 (29%), Positives = 168/380 (44%), Gaps = 52/380 (13%)
Query: 40 EGQEPSQIIFQFKANPPA---VTFELTGETDN-----IFVIERE-GLLYYNRALDRETRS 90
+G P ++ Q K+N V + +TG+ + +F+IERE G L LDRE +
Sbjct: 168 KGPFPKNLV-QIKSNKDKEGKVFYSITGQGADTPPVGVFIIERETGWLKVTEPLDRERIA 226
Query: 91 THNLQVAALDANGIIVEGPVPITIKVKDINDNRPTFLQSKYEGSVRQNSRPGKPFLYVNA 150
T+ L A+ +NG VE P+ I I V D NDN+P F Q ++GSV + + PG + V A
Sbjct: 227 TYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTA 286
Query: 151 TDLDDPA-TPNGQLYYQIVIQLPMINNVMYFQINNKTGAISLTREGSQELNPAKNPSYNL 209
TD DD T N + Y I+ Q P + + F IN TG IS+ G L+ P+Y L
Sbjct: 287 TDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTG---LDRESFPTYTL 343
Query: 210 VISVKDMGGQSENSFSDTTSVDIIVTENIWKAP--KPV----EMVENSTDP--HPIKITQ 261
V+ D+ G+ S T + I VT+ P P ++ EN + +K+T
Sbjct: 344 VVQAADLQGE---GLSTTATAVITVTDTNDNPPIFNPTTYKGQVPENEANVVITTLKVTD 400
Query: 262 V------RW-------NDPGAQYSLVDKEKLPRFPFSIDQEGDIYVTQPLDREEKDAYVF 308
W ND G Q+ + ++ +G + + LD E K Y+
Sbjct: 401 ADAPNTPAWEAVYTILNDDGGQFVVTTN--------PVNNDGILKTAKGLDFEAKQQYIL 452
Query: 309 YAVAKDEYGKPLSYPLE---IHVKVKDINDNPPTCPSPVTVFEVQENERLGNSIGTLTAH 365
+ + +S + V V D+N+ P P P EV E+ +G I + TA
Sbjct: 453 HVAVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVP-PEKRVEVSEDFGVGQEITSYTAQ 511
Query: 366 DRDEENTANSFLNYRIVEQT 385
+ D + YRI T
Sbjct: 512 EPD--TFMEQKITYRIWRDT 529
Score = 31.2 bits (69), Expect = 4.1
Identities = 24/92 (26%), Positives = 38/92 (41%), Gaps = 12/92 (13%)
Query: 39 YEGQEPSQIIFQFKANPPAVTFELTGETDNIFVIERE-GLLYYNRALDRET-----RSTH 92
Y QEP + Q +T+ + +T N I + G + LDRE ST+
Sbjct: 508 YTAQEPDTFMEQ------KITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNSTY 561
Query: 93 NLQVAALDANGIIVEGPVPITIKVKDINDNRP 124
+ A D + G + + + D+NDN P
Sbjct: 562 TALIIATDNGSPVATGTGTLLLILSDVNDNAP 593
>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
Length = 4588
Score = 209 bits (531), Expect = 1e-53
Identities = 203/764 (26%), Positives = 344/764 (45%), Gaps = 79/764 (10%)
Query: 67 DNIFVIERE-GLLYYNRALDRETRSTHNLQVAAL---DANGIIVEGPVPITIKVKDINDN 122
D FVI+R+ G L ++LD ET + + A D + ++ V ++I+VKD NDN
Sbjct: 2748 DESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVAS--VDVSIQVKDANDN 2805
Query: 123 RPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQI 182
P F S YE + +N G + + A+D D NGQ+ Y + Q + + F I
Sbjct: 2806 SPVFESSPYEAFIVENLPGGSRVIQIRASDADSGT--NGQVMYSLD-QSQSVEVIESFAI 2862
Query: 183 NNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTENIWKAP 242
N +TG I+ +E L+ K +Y + + D G + + S T VD+ VT+ P
Sbjct: 2863 NMETGWITTLKE----LDHEKRDNYQIKVVASDHGEKIQ--LSSTAIVDVTVTDVNDSPP 2916
Query: 243 KPVEMVENST----DPHPIKITQVRWNDPGAQ-------YSLVDKEKLPRFPF-SIDQEG 290
+ + T DP I + D ++ Y + + L +F +I E
Sbjct: 2917 RFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEW 2976
Query: 291 DIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQ 350
+YV +PLDRE++D Y+ A D S + VKV D NDN P C + +
Sbjct: 2977 KVYVKKPLDREKRDNYLLTITATDG---TFSSKAIVEVKVLDANDNSPVCEKTLYSDTIP 3033
Query: 351 ENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSL 410
E+ G I ++A D D + A + Y ++ + F + G L+ + L
Sbjct: 3034 EDVLPGKLIMQISATDADIRSNAE--ITYTLLGSGAEK-----FKLNPDTGELKTSTP-L 3085
Query: 411 KKQDTPQYNLTIEVSDKDFKTLCFVQINVI----DINDQIPIFEKSDYGNLTLAEDTNIG 466
+++ Y+L + +D + F Q +++ D+ND P F Y +T+ E+T G
Sbjct: 3086 DREEQAVYHLLVRATDGGGR---FCQASIVLTLEDVNDNAPEFSADPYA-ITVFENTEPG 3141
Query: 467 STILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAV 526
+ + +QATDAD + KILY +I ++G+ ++ +G + ++KPLD E AV
Sbjct: 3142 TLLTRVQATDADAGL--NRKILYSLIDS-ADGQFSINE----LSGIIQLEKPLDRELQAV 3194
Query: 527 SNIVFKAENPEPLVFGVKYNASSFAKFTLIVTDVNEAPQ-FSQHVFQAKVSEDVAIGTKV 585
+ KA + G+ ++ + V D+N+ P F + A VSED+ +GT+V
Sbjct: 3195 YTLSLKAVDQ-----GLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEV 3249
Query: 586 GNVTAKDPE---GLDISYSL-RGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATE 641
V A + +I+YS+ G+ G ID TG +F + LD E+ Y + V AT+
Sbjct: 3250 LQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATD 3309
Query: 642 VGGSSLSSVSEFHLILMDVNDNPPRLAKDYTGLFFCHPLSAPGSLIFEATDDDQHLFRGP 701
G SLS V+ ++ + D+NDN P ++D S+I DD GP
Sbjct: 3310 GGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDAD----GP 3365
Query: 702 ---HFTFSLGSGSLQNDWEVSKINGTHARLSTRHTEFEERE----YVVLIRINDGGRPPL 754
H +S+ G+ + + + + G + T+ +RE Y + ++ +D G PP
Sbjct: 3366 SNSHIHYSIIDGNQGSSFTIDPVRG-----EVKVTKLLDRETISGYTLTVQASDNGSPPR 3420
Query: 755 EGIVSLPVTFCSCVEGSCFRPAGHQTGIPTVGMAVGILLTTLLV 798
++ + + + G+ + I VG + L+V
Sbjct: 3421 VNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVV 3464
Score = 155 bits (391), Expect = 2e-37
Identities = 191/721 (26%), Positives = 300/721 (41%), Gaps = 102/721 (14%)
Query: 107 EGPVPITIKVKDINDNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQ 166
E V TI + ++NDN P F + EG++ ++ G+ V+A D D+ Q
Sbjct: 550 EVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADE---------LQ 600
Query: 167 IV-IQLPMINNVMYFQINNKTGAISLTREGSQELNPAKNPSYNLVISVKD---------- 215
+V Q+ N + +F +N +G +SL R L AK ++L I+ D
Sbjct: 601 LVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLG-AKVSFHSLRITATDGENFATPLYI 659
Query: 216 -----------------------------------MGGQSENSFSDTTSVDIIVTENIWK 240
G+ E+ F D+ SV+ + +
Sbjct: 660 NITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRST 719
Query: 241 APKPVEMVENSTDPHPIKITQVRWNDPGAQYSLVDKEKLPRFP--FSIDQE-GDIYVTQP 297
P +++ EN + D G LV F ID E G + + P
Sbjct: 720 LPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSP 779
Query: 298 LDREEKDAYVFYAVAKDEYGKPLSYPLEI-HVKVKDINDNPPTCPSPVTVFEVQENERLG 356
LDRE D Y D G P + HV V D NDNPP EV E++ +
Sbjct: 780 LDRETTDKYTLNITVYD-LGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVH 838
Query: 357 NSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTP 416
+ I + A D+D N + Y IV T F I + G++ +A+ L ++
Sbjct: 839 SEIIQVEATDKDLG--PNGHVTYSIVTDTDT------FSIDSVTGVVNIARP-LDRELQH 889
Query: 417 QYNLTIEVSDKD------FKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTIL 470
+++L IE D+ F T+ V++++ D+ND P F +Y + + ED G+ I+
Sbjct: 890 EHSLKIEARDQAREEPQLFSTVV-VKVSLEDVNDNPPTFIPPNY-RVKVREDLPEGTVIM 947
Query: 471 TIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVSNIV 530
++A D D G S + + + EG VD +G V I + LDFE V N+
Sbjct: 948 WLEAHDPD---LGQSGQVRYSLLDHGEGNFDVDK----LSGAVRIVQQLDFEKKQVYNLT 1000
Query: 531 FKAENPEPLVFGVKYNASSFAKFTLIVTDVNE---APQFSQHVFQAKVSEDVAIGTKVGN 587
+A++ G + SS + V DVNE P FS V + V ED +G+ V
Sbjct: 1001 VRAKDK-----GKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMT 1055
Query: 588 VTAKDPEGL---DISYSLR-GDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVG 643
V+A D + +I YS+R G G KI TG I + LDRE+ S Y + V AT+ G
Sbjct: 1056 VSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQG 1115
Query: 644 GSSLSSVSEFHLILMDVNDNPPRLAKD--YTGLFFCHPLSAPGSLIFEATDDDQHLFRGP 701
LSS E ++ + DVNDN P+ ++ Y + P + EA D D
Sbjct: 1116 VVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDV-SVVQIEAFDPDSS--SND 1172
Query: 702 HFTFSLGSGSLQNDWEVSKINGTHARLSTRHTEFEEREYVVLIRINDGGRPPLEGIVSLP 761
+ + SG+ Q + + G S + ++ E+++ + + D G PP I +
Sbjct: 1173 KLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVI 1232
Query: 762 V 762
V
Sbjct: 1233 V 1233
Score = 151 bits (381), Expect = 3e-36
Identities = 183/725 (25%), Positives = 321/725 (44%), Gaps = 92/725 (12%)
Query: 58 VTFELTGETD----NIFVIEREGLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPIT 113
VT+ +TG + I+ E +Y + LDRE R + L + A D +
Sbjct: 2954 VTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDGT---FSSKAIVE 3010
Query: 114 IKVKDINDNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPM 173
+KV D NDN P ++ Y ++ ++ PGK + ++ATD D N ++ Y + +
Sbjct: 3011 VKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDAD--IRSNAEITYTL-----L 3063
Query: 174 INNVMYFQINNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDII 233
+ F++N TG + S L+ + Y+L++ D GG+ + T D+
Sbjct: 3064 GSGAEKFKLNPDTGELKT----STPLDREEQAVYHLLVRATDGGGRFCQASIVLTLEDVN 3119
Query: 234 VTENIWKAPKPVEMVENSTDPHPIKITQVRWNDPGAQ------YSLVDKEKLPRFPFSID 287
+ A V +T+P + +T+V+ D A YSL+D FSI+
Sbjct: 3120 DNAPEFSADPYAITVFENTEPGTL-LTRVQATDADAGLNRKILYSLIDSAD---GQFSIN 3175
Query: 288 Q-EGDIYVTQPLDREEKDAYVFYAVAKDEYGKP--LSYPLEIHVKVKDINDNPPTCPSPV 344
+ G I + +PLDRE + Y A D+ G P L+ + V V DINDNPP
Sbjct: 3176 ELSGIIQLEKPLDRELQAVYTLSLKAVDQ-GLPRRLTATGTVIVSVLDINDNPPVFEYRE 3234
Query: 345 TVFEVQENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQ 404
V E+ +G + + A RD E AN+ + Y I+ G F I + G +
Sbjct: 3235 YGATVSEDILVGTEVLQVYAASRDIE--ANAEITYSIISGNEH----GKFSIDSKTGAVF 3288
Query: 405 LAKQSLKKQDTPQYNLTIEVSDKDFKTL---CFVQINVIDINDQIPIFEKSDYGNLTLAE 461
+ ++L + + +Y LT+E +D +L V +NV DIND P+F + Y + ++E
Sbjct: 3289 II-ENLDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTV-ISE 3346
Query: 462 DTNIGSTILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDF 521
D + +++T+ A DAD P +S I Y II G+ +D G V + K LD
Sbjct: 3347 DAVLEQSVITVMADDADGP--SNSHIHYSIIDGNQGSSFTIDPV----RGEVKVTKLLDR 3400
Query: 522 ETAAVSNIVFKA-ENPEPLVFGVKYNASSFAKFTLIVTDVNE-APQFSQHVFQAKVSEDV 579
ET + + +A +N P + N ++ + V+DVN+ AP FS+ + + E+
Sbjct: 3401 ETISGYTLTVQASDNGSP----PRVNTTTV---NIDVSDVNDNAPVFSRGNYSVIIQENK 3453
Query: 580 AIGTKVGNVTAKDPE----GLDISYSL-RGDTRGWLKIDHVTGEIFSVAPLDREAGSPYR 634
+G V + D + G +++ G+ +++ G + + + + R+ Y
Sbjct: 3454 PVGFSVLQLVVTDEDSSHNGPPFFFTIVTGNDEKAFEVNP-QGVLLTSSAIKRKEKDHYL 3512
Query: 635 VQVVATEVGGSSLSSVSEFHLILMDVNDNPPRL----------AKDYTGLFFCHPLSAPG 684
+QV + G LSS++ + +++ + PP + ++Y+G G
Sbjct: 3513 LQVKVADNGKPQLSSLTYIDIRVIEESIYPPAILPLEIFITSSGEEYSG-------GVIG 3565
Query: 685 SLIFEATDDDQHLFRGPHFTFSLGSGSLQNDWEVSKINGTHARLSTRHTEFEEREYVVLI 744
+ ATD D + T+SL + N + VS G H + + +Y++ +
Sbjct: 3566 KI--HATDQDVY----DTLTYSL-DPQMDNLFSVSSTGGK----LIAHKKLDIGQYLLNV 3614
Query: 745 RINDG 749
+ DG
Sbjct: 3615 SVTDG 3619
Score = 149 bits (375), Expect = 1e-35
Identities = 163/640 (25%), Positives = 281/640 (43%), Gaps = 68/640 (10%)
Query: 58 VTFELTGETDNIFVIEREGLLYYNRALDRETRSTHNLQVAALDANGIIVE--GPVPITIK 115
VT+ + +TD + G++ R LDRE + H+L++ A D + V + +
Sbjct: 857 VTYSIVTDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVS 916
Query: 116 VKDINDNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMIN 175
++D+NDN PTF+ Y VR++ G +++ A D D +GQ+ Y + + +
Sbjct: 917 LEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPD--LGQSGQVRYSL-----LDH 969
Query: 176 NVMYFQINNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDII-V 234
F ++ +GA+ + Q+L+ K YNL + KD G S + V+++ V
Sbjct: 970 GEGNFDVDKLSGAVRIV----QQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDV 1025
Query: 235 TENIWKAPKPVEMVENST----DPHPIKITQVRWNDPGAQ------YSLVDKEKLPRFPF 284
EN+ P VE T P + V +D A+ YS+ D + F
Sbjct: 1026 NENL-HPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKI 1084
Query: 285 SIDQEGDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPV 344
++ G I + LDRE Y A D+ PLS +EI+++V+D+NDN P PV
Sbjct: 1085 G-EETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPV 1143
Query: 345 TVFEVQENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQ 404
E+ EN S+ + A D D +++N L Y+I P+ G F I G++
Sbjct: 1144 YYPEIMENSPKDVSVVQIEAFDPD--SSSNDKLMYKITSGNPQ----GFFSIHPKTGLIT 1197
Query: 405 LAKQSLKKQDTPQYNLTIEVSDKDF---KTLCFVQINVIDINDQIPIFEKSDYGNLTLAE 461
+ L ++ ++ L + V+D T+ V + ++D ND P F + Y + L E
Sbjct: 1198 TTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFY-KIRLPE 1256
Query: 462 ------DTNI-GSTILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVI 514
+ N + + ATD DE +++I Y I G+ G+ ++ TG V
Sbjct: 1257 REKPDRERNARREPLYHVIATDKDE--GPNAEISYSIEDGNEHGKFFIE----PKTGVVS 1310
Query: 515 IKKPLDFETAAVSNI--VFKAENPEP---LVFGVKYNASSFAKFTLIVTDVNEAPQFSQH 569
K+ F A +I + +N P + S K +L E F +
Sbjct: 1311 SKR---FSAAGEYDILSIKAVDNGRPQKSSTTRLHIEWISKPKPSL------EPISFEES 1361
Query: 570 VFQAKVSEDVAIGTKVGNVTAKDPEGLDISYSLR-GDTRGWLKIDHVTGEIFSVAPLDRE 628
F V E + +G V + +P G+ + + + G+ +D TG I PLD E
Sbjct: 1362 FFTFTVMESDPVAHMIG-VISVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAE 1420
Query: 629 AGSPYRVQVVATEVGGSSLSSVSEFHLILMDVNDNPPRLA 668
S Y + V AT+ + + +++ + ++D ND+ P+ +
Sbjct: 1421 QKSNYNLTVEATD---GTTTILTQVFIKVIDTNDHRPQFS 1457
Score = 138 bits (347), Expect = 2e-32
Identities = 159/609 (26%), Positives = 271/609 (44%), Gaps = 59/609 (9%)
Query: 87 ETRSTHNLQVAALDANGIIVEGPVP-ITIKVKDINDNRPTFLQSKYEG-SVRQNSRPGKP 144
ET L L AN + +G V I +N + P F + G V++N G
Sbjct: 676 ETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSS 735
Query: 145 FLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQINNKTGAISLTREGSQELNPAKN 204
+++N+TDLD NG+L Y + N F I+ +TG + + L+
Sbjct: 736 VIFMNSTDLDTGF--NGKLVYAVSGG----NEDSCFMIDMETGMLKIL----SPLDRETT 785
Query: 205 PSYNLVISVKDMGGQSENSFSDTTSVDIIVTENIWKAPKPVEMVENSTDPHP-IKITQVR 263
Y L I+V D+G + ++ V + +N + + VE S D +I QV
Sbjct: 786 DKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVE 845
Query: 264 WNDPG------AQYSLVDKEKLPRFPFSIDQ-EGDIYVTQPLDREEKDAYVFYAVAKDEY 316
D YS+V FSID G + + +PLDRE + + A+D+
Sbjct: 846 ATDKDLGPNGHVTYSIVTDTDT----FSIDSVTGVVNIARPLDRELQHEHSLKIEARDQA 901
Query: 317 GKP--LSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERLGNSIGTLTAHDRDEENTAN 374
+ L + + V ++D+NDNPPT P +V+E+ G I L AHD D +
Sbjct: 902 REEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQ 961
Query: 375 SFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTPQYNLTIEVSDK----DFK 430
+ Y +++ +G F + +G +++ +Q L + YNLT+ DK
Sbjct: 962 --VRYSLLDHG-----EGNFDVDKLSGAVRIVQQ-LDFEKKQVYNLTVRAKDKGKPVSLS 1013
Query: 431 TLCFVQINVIDINDQI--PIFEKSDYGNLTLAEDTNIGSTILTIQATDADEPFTGSSKIL 488
+ C+V++ V+D+N+ + P+F S T+ ED +GS ++T+ A D D G +I
Sbjct: 1014 STCYVEVEVVDVNENLHPPVFS-SFVEKGTVKEDAPVGSLVMTVSAHDEDARRDG--EIR 1070
Query: 489 YHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVSNIVFKAENPEPLVFGVKYNAS 548
Y I G G + + TG + LD E+ + + A + + S
Sbjct: 1071 YSIRDGSGVGVFKIGEE----TGVIETSDRLDRESTSHYWLTVFATDQGVVPL------S 1120
Query: 549 SFAKFTLIVTDVNE-APQFSQHVFQAKVSEDVAIGTKVGNVTAKDPEGLD---ISYSLR- 603
SF + + V DVN+ APQ S+ V+ ++ E+ V + A DP+ + Y +
Sbjct: 1121 SFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITS 1180
Query: 604 GDTRGWLKIDHVTGEIFSVA-PLDREAGSPYRVQVVATEVGGSSLSSVSEFHLILMDVND 662
G+ +G+ I TG I + + LDRE + ++V T+ G S+++ + ++D ND
Sbjct: 1181 GNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDEND 1240
Query: 663 NPPRLAKDY 671
N P+ + +
Sbjct: 1241 NKPQFLQKF 1249
Score = 134 bits (336), Expect = 5e-31
Identities = 163/624 (26%), Positives = 262/624 (41%), Gaps = 80/624 (12%)
Query: 81 NRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNRPTFLQSKYEGSVRQNSR 140
+R LDRE + H L+V D + +K+ D NDN+P FLQ Y+ + + +
Sbjct: 1200 SRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREK 1259
Query: 141 PGK-------PFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQINNKTGAISLTR 193
P + P +V ATD D+ PN ++ Y I N F I KTG +S R
Sbjct: 1260 PDRERNARREPLYHVIATDKDEG--PNAEISYSIEDG----NEHGKFFIEPKTGVVSSKR 1313
Query: 194 EGSQELNPAKNPSYNLVISVKDM-GGQSENSFSDTTSVDIIVTENIWKAPKPVEMVENST 252
+ Y+ ++S+K + G+ + S + ++ I KP +E +
Sbjct: 1314 FSAAG-------EYD-ILSIKAVDNGRPQKSSTTRLHIEWI--------SKPKPSLEPIS 1357
Query: 253 DPHPIKITQVRWNDPGAQYSLVDKEKLPRFP-------------FSIDQ-EGDIYVTQPL 298
V +DP A V + P P F +D+ G I V +PL
Sbjct: 1358 FEESFFTFTVMESDPVAHMIGVISVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPL 1417
Query: 299 DREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERLGNS 358
D E+K Y A D L+ ++ +KV D ND+ P + + E+
Sbjct: 1418 DAEQKSNYNLTVEATDGTTTILT---QVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETE 1474
Query: 359 IGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTPQY 418
I ++A D+DE+N L Y + L + F + G L + L + Q+
Sbjct: 1475 ILQISAVDQDEKNK----LIYTLQSSRDPLSLK-KFRLDPATGSL-YTSEKLDHEAVHQH 1528
Query: 419 NLTIEVSDKDF---KTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQAT 475
LT+ V D+D + + +NV D ND P F S Y + E +GS +L + A
Sbjct: 1529 TLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKG-RVYESAAVGSVVLQVTAL 1587
Query: 476 DADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVSNIVFKA-- 533
D D+ ++++LY I G+ +D G + K LD A +++ KA
Sbjct: 1588 DKDK--GKNAEVLYSIESGNIGNSFMID----PVLGSIKTAKELDRSNQAEYDLMVKATD 1641
Query: 534 ENPEPLVFGVKYNASSFAKFTLIVTDV-NEAPQFSQHVFQAKVSEDVAIGTKVGNVTAKD 592
+ P+ S + VT N +P+F+ + ++SE V+IG+ VG VTA
Sbjct: 1642 KGSPPM--------SEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHS 1693
Query: 593 PEGLDISYSLR-GDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSLSSVS 651
+ Y ++ G+T I+ +G I + LD E Y + + T + G S ++
Sbjct: 1694 QS--SVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMAGLSTNTTV 1751
Query: 652 EFHLILMDVNDNPP-RLAKDYTGL 674
H L D NDN P + +YTGL
Sbjct: 1752 LVH--LQDENDNAPVFMQAEYTGL 1773
Score = 132 bits (332), Expect = 1e-30
Identities = 173/690 (25%), Positives = 290/690 (42%), Gaps = 80/690 (11%)
Query: 67 DNIFVIEREGLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNRPTF 126
D+ V GL+ R LD E H + V A+D + V +T+ V D+NDN P F
Sbjct: 2331 DHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLF 2390
Query: 127 LQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQINNKT 186
Q YE + +++ G V A D D ++ +L Y I+ N+ +F I++ T
Sbjct: 2391 EQQIYEARISEHAPHGHFVTCVKAYDAD--SSDIDKLQYSILSG----NDHKHFVIDSAT 2444
Query: 187 GAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTENIWKAPK--- 243
G I+L S A P Y+L +SV S+ F +T V + V +P
Sbjct: 2445 GIITL----SNLHRHALKPFYSLNLSV------SDGVFRSSTQVHVTVIGGNLHSPAFLQ 2494
Query: 244 ---PVEMVENSTDPHPIKITQVRWNDPGA------QYSLVDKEKLPRFPFSIDQEGDIYV 294
VE+ EN+ P + +V+ D + Y +V+ R F I++ G I+
Sbjct: 2495 NEYEVELAENA--PLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDR--FYINERGQIFT 2550
Query: 295 TQPLDREEKDAYVFYA--VAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQEN 352
+ LDRE V +AKD GK ++V + D NDN P + + +
Sbjct: 2551 LEKLDRETPAEKVISVRLMAKDAGGKVAF--CTVNVILTDDNDNAPQFRATKYEVNIGSS 2608
Query: 353 ERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKK 412
G S+ + A D DE + A+ + Y I + + + I +G++ K+SL
Sbjct: 2609 AAKGTSVVKVLASDADEGSNAD--ITYAIEADSESVKEN--LEINKLSGVI-TTKESLIG 2663
Query: 413 QDTPQYNLTIEVSDK---DFKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTI 469
+ + + D +++ V + ++ Q+P F + Y T++ED IG+ I
Sbjct: 2664 LENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFY-TFTVSEDVPIGTEI 2722
Query: 470 LTIQATDADEPFTGSSKILYHIIKGDS-EGRLGVDTDPHTNTGYVIIKKPLDFETAAVSN 528
I+A S +LY ++KG++ E +G + ++K LD ET
Sbjct: 2723 DLIRAEH-------SGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQ 2775
Query: 529 IVFKAENPEPLVFGVKYNASSFAKFTLIVTDVNE-APQFSQHVFQAKVSEDVAIGTKVGN 587
A + + + ++ V D N+ +P F ++A + E++ G++V
Sbjct: 2776 FSILARCTQD-----DHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQ 2830
Query: 588 VTAKDPE---------GLDISYSLRGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVV 638
+ A D + LD S S+ + I+ TG I ++ LD E Y+++VV
Sbjct: 2831 IRASDADSGTNGQVMYSLDQSQSV--EVIESFAINMETGWITTLKELDHEKRDNYQIKVV 2888
Query: 639 ATEVGGS-SLSSVSEFHLILMDVNDNPPRL-AKDYTGLFFCHPLSAPGSLIFEATDDDQH 696
A++ G LSS + + + DVND+PPR A+ Y G I TD D
Sbjct: 2889 ASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSE 2948
Query: 697 LFRGPHFTFSLGSG--------SLQNDWEV 718
F G ++QN+W+V
Sbjct: 2949 EINRQVTYFITGGDPLGQFAVETIQNEWKV 2978
Score = 132 bits (331), Expect = 2e-30
Identities = 159/612 (25%), Positives = 258/612 (42%), Gaps = 72/612 (11%)
Query: 76 GLLYYNRALDRETRSTHN--LQVAALDANGIIVEGPVPITIKVKDINDNRPTFLQSKYEG 133
G ++ +LD E S + +QV + + E +T+ V DIND P F + YE
Sbjct: 1827 GAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEA 1886
Query: 134 SVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQINNKTGAISLTR 193
S+ + G + VNATD D A + Q++ + N F ++ KTGA LT
Sbjct: 1887 SLLLPTYKGVKVITVNATDADSSA------FSQLIYSITEGNIGEKFSMDYKTGA--LTV 1938
Query: 194 EGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTENIWKAPKPVEMV----- 248
+ + +L Y L + D F+ TSV I V E+ K + V
Sbjct: 1939 QNTTQLRSR----YELTVRASD------GRFAGLTSVKINVKESKESHLKFTQDVYSAVV 1988
Query: 249 -ENSTDPHPIKITQVRWNDPGAQ--YSLVDKEKLPRFPFSIDQEGDIYVTQ--PLDREEK 303
ENST+ + + N Y +++ ++ F I + + T P DRE++
Sbjct: 1989 KENSTEAETLAVITAIGNPINEPLFYHILNPDRR----FKISRTSGVLSTTGTPFDREQQ 2044
Query: 304 DAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERLGNSIGTLT 363
+A+ +E+ + + V V+D NDN P + V+ + +G+ I +T
Sbjct: 2045 EAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVT 2104
Query: 364 AHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTPQYNLTIE 423
A DRD + N ++Y + E + L G + L KQ +Y +T+
Sbjct: 2105 AVDRD--SGRNGEVHYYLKEHHEHFQIGPL-------GEISLKKQFELDTLNKEYLVTVV 2155
Query: 424 VSD---KDFKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQATDADEP 480
D F V I V +N +P+FEK Y + +AE + S ++ +QA +
Sbjct: 2156 AKDGGNPAFSAEVIVPITV--MNKAMPVFEKPFY-SAEIAESIQVHSPVVHVQANSPE-- 2210
Query: 481 FTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVSNIVFKAENPEPLV 540
K+ Y I GD + + + NTG + + PLDFE + +A +
Sbjct: 2211 ---GLKVFYSITDGDPFSQFTI----NFNTGVINVIAPLDFEAHPAYKLSIRATDS---- 2259
Query: 541 FGVKYNASSFAKFTLIVTDVNE-APQFSQHVFQAKVSEDVAIGTKVGNVTAKDPE---GL 596
A + +IV D+N+ P F+Q + +SE IGT V V A D +
Sbjct: 2260 ---LTGAHAEVFVDIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNR 2316
Query: 597 DISYSLRGD---TRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSLSSVSEF 653
ISY + G+ + +D TG I + LD E + + V A + G +LSS
Sbjct: 2317 GISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIV 2376
Query: 654 HLILMDVNDNPP 665
+ + D+NDNPP
Sbjct: 2377 TVDVTDLNDNPP 2388
Score = 129 bits (325), Expect = 9e-30
Identities = 165/698 (23%), Positives = 290/698 (41%), Gaps = 74/698 (10%)
Query: 85 DRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNRPTFLQSKYEGSVRQNSRPGKP 144
DRE + ++ V + + V + + V+D NDN P F+ Y V+ ++ G
Sbjct: 2040 DREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHV 2099
Query: 145 FLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQINNKTGAISLTREGSQELNPAKN 204
YV A D D + NG+++Y + + +FQI G ISL ++ + N
Sbjct: 2100 IRYVTAVDRD--SGRNGEVHYYLK------EHHEHFQI-GPLGEISLKKQFELD---TLN 2147
Query: 205 PSYNLVISVKDMGGQSENSFSDTTSVDIIVTEN---IWKAPKPVEMVENSTDPHPIKITQ 261
Y + + KD G +FS V I V +++ P + S H +
Sbjct: 2148 KEYLVTVVAKDGGNP---AFSAEVIVPITVMNKAMPVFEKPFYSAEIAESIQVHS-PVVH 2203
Query: 262 VRWNDPGAQ---YSLVDKEKLPRFPFSIDQEGDIYVTQPLDREEKDAYVFYAVAKDEYGK 318
V+ N P YS+ D + +F + + G I V PLD E AY A D
Sbjct: 2204 VQANSPEGLKVFYSITDGDPFSQFTINFN-TGVINVIAPLDFEAHPAYKLSIRATDSL-T 2261
Query: 319 PLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERLGNSIGTLTAHDRDEENTANSFLN 378
+ + + V DINDNPP + E +G S+ + A D D E N ++
Sbjct: 2262 GAHAEVFVDIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSE--PNRGIS 2319
Query: 379 YRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTPQYNLTIEVSDKDFKTL---CFV 435
Y++ K F + + G++ L + +L + + Q+ + + D TL V
Sbjct: 2320 YQMFGNHSK--SHDHFHVDSSTGLISLLR-TLDYEQSRQHTIFVRAVDGGMPTLSSDVIV 2376
Query: 436 QINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQATDADEPFTGSSKILYHIIKGD 495
++V D+ND P+FE+ Y ++E G + ++A DAD + K+ Y I+ G+
Sbjct: 2377 TVDVTDLNDNPPLFEQQIY-EARISEHAPHGHFVTCVKAYDADS--SDIDKLQYSILSGN 2433
Query: 496 SEGRLGVDTDPHTNTGYVIIK-------KPLDFETAAVSNIVFKAENPEPLVFGVKYNAS 548
+D + TG + + KP +VS+ VF+ S
Sbjct: 2434 DHKHFVID----SATGIITLSNLHRHALKPFYSLNLSVSDGVFR---------------S 2474
Query: 549 SFAKFTLIVTDVNEAPQFSQHVFQAKVSEDVAIGTKVGNVTAKDPE-GL--DISYSLRGD 605
S ++ +P F Q+ ++ +++E+ + T V V D + G+ ++Y + D
Sbjct: 2475 STQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVND 2534
Query: 606 TRGWLKIDHVTGEIFSVAPLDRE--AGSPYRVQVVATEVGGSSLSSVSEFHLILMDVNDN 663
+ G+IF++ LDRE A V+++A + GG + ++IL D NDN
Sbjct: 2535 FAKDRFYINERGQIFTLEKLDRETPAEKVISVRLMAKDAGGK--VAFCTVNVILTDDNDN 2592
Query: 664 PPRL-AKDYTGLFFCHPLSAPGSLIFEATDDDQHLFRGPHFTFSLGSGSLQNDWEVSKIN 722
P+ A Y + A+D D+ + S S++ + E++K++
Sbjct: 2593 APQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESVKENLEINKLS 2652
Query: 723 GTHARLSTRHT--EFEEREYVVLIRINDGGRPPLEGIV 758
G ++T+ + E + +R D G P E +V
Sbjct: 2653 GV---ITTKESLIGLENEFFTFFVRAVDNGSPSKESVV 2687
Score = 128 bits (321), Expect = 2e-29
Identities = 178/726 (24%), Positives = 287/726 (39%), Gaps = 102/726 (14%)
Query: 76 GLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNRPTFLQSKYEGSV 135
G LY + LD E H L V D + + I + V D ND+ P F S Y+G V
Sbjct: 1512 GSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRV 1571
Query: 136 RQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQINNKTGAISLTREG 195
+++ G L V A D D N ++ Y I + I N F I+ G+I +E
Sbjct: 1572 YESAAVGSVVLQVTALDKDKGK--NAEVLYSI--ESGNIGNS--FMIDPVLGSIKTAKE- 1624
Query: 196 SQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTENIWKAPK------PVEMVE 249
L+ + Y+L++ D G S+ TSV I VT +PK VE+ E
Sbjct: 1625 ---LDRSNQAEYDLMVKATDKGSPP---MSEITSVRIFVTIADNASPKFTSKEYSVELSE 1678
Query: 250 NSTDPHPIKITQVRWNDPGAQYSLVDKEKLPRFPFSIDQEGDIYVTQPLDREEKDAYVFY 309
+ + + + Y + D F + G I + LD E Y
Sbjct: 1679 TVSIGSFVGMVTAH-SQSSVVYEIKDGNTGDAFDIN-PHSGTIITQKALDFETLPIYTLI 1736
Query: 310 AVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERLGNSIGT-----LTA 364
+ G LS + V ++D NDN P + E+ + + + T L
Sbjct: 1737 IQGTNMAG--LSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVI 1794
Query: 365 HDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTPQYNLTIEV 424
D + +N+ L Y IVE + + F I + G + SL ++T ++ T++V
Sbjct: 1795 RAADADKDSNALLVYHIVEPS----VHTYFAIDSSTGAIHTVL-SLDYEETSIFHFTVQV 1849
Query: 425 SDKDFKTL-----CFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQATDADE 479
D L V ++VIDIND P+F K Y +L T G ++T+ ATDAD
Sbjct: 1850 HDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLY-EASLLLPTYKGVKVITVNATDADS 1908
Query: 480 PFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVSNIVFKAENPEPL 539
+ S+++Y I +EG +G K +D++T A++ + +
Sbjct: 1909 --SAFSQLIYSI----TEGNIGE-------------KFSMDYKTGALT-VQNTTQLRSRY 1948
Query: 540 VFGVKYNASSFAKFTLIVTDVNEAPQ----FSQHVFQAKVSEDVAIGTKVGNVTA-KDPE 594
V+ + FA T + +V E+ + F+Q V+ A V E+ + +TA +P
Sbjct: 1949 ELTVRASDGRFAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPI 2008
Query: 595 GLDISYSLRGDTRGWLKIDHVTGEIFSVA-PLDREAGSPYRVQVVATEVGGSSLSSVSEF 653
+ Y + R + KI +G + + P DRE + V V TE S +
Sbjct: 2009 NEPLFYHILNPDRRF-KISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVV 2067
Query: 654 HLILMDVNDNPPRLAK----------DYTGLFFCHPLSAP------GSLIFEATDDDQHL 697
+I+ D NDN P G + + G + + + +H
Sbjct: 2068 KVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHEHF 2127
Query: 698 FRGPHFTFSLGSGSLQNDWEVSKINGTHARLSTRHTEFEEREYVVLIRINDGGRPPLEGI 757
GP LG SL+ +E+ +N +EY+V + DGG P
Sbjct: 2128 QIGP-----LGEISLKKQFELDTLN---------------KEYLVTVVAKDGGNPAFSAE 2167
Query: 758 VSLPVT 763
V +P+T
Sbjct: 2168 VIVPIT 2173
Score = 126 bits (316), Expect = 9e-29
Identities = 165/626 (26%), Positives = 272/626 (43%), Gaps = 75/626 (11%)
Query: 64 GETDNIFVIERE-GLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDN 122
G D+ F+I+ E G+L LDRET + L + D + + V D NDN
Sbjct: 759 GNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDN 818
Query: 123 RPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQI 182
P FLQ Y V ++ + V ATD D PNG + Y IV + F I
Sbjct: 819 PPEFLQESYFVEVSEDKEVHSEIIQVEATDKD--LGPNGHVTYSIV------TDTDTFSI 870
Query: 183 NNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTENIWKAP 242
++ TG +++ R +EL ++L I +D + FS T V + E++ P
Sbjct: 871 DSVTGVVNIARPLDREL----QHEHSLKIEARDQAREEPQLFS--TVVVKVSLEDVNDNP 924
Query: 243 ----KPVEMVENSTD-PHPIKITQVRWNDPG------AQYSLVDKEKLPRFPFSIDQ-EG 290
P V+ D P I + +DP +YSL+D + F +D+ G
Sbjct: 925 PTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGE---GNFDVDKLSG 981
Query: 291 DIYVTQPLDREEKDAYVFYAVAKDEYGKP--LSYPLEIHVKVKDINDN--PPTCPSPVTV 346
+ + Q LD E+K Y AKD+ GKP LS + V+V D+N+N PP S V
Sbjct: 982 AVRIVQQLDFEKKQVYNLTVRAKDK-GKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEK 1040
Query: 347 FEVQENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLA 406
V+E+ +G+ + T++AHD D + Y I + + G+F I G+++ +
Sbjct: 1041 GTVKEDAPVGSLVMTVSAHDEDARRDGE--IRYSIRDGSGV----GVFKIGEETGVIETS 1094
Query: 407 KQSLKKQDTPQYNLTIEVSDK---DFKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDT 463
+ L ++ T Y LT+ +D+ + + I V D+ND P + Y + E++
Sbjct: 1095 DR-LDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVY-YPEIMENS 1152
Query: 464 NIGSTILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYV-IIKKPLDFE 522
+++ I+A D D + + K++Y I G+ +G + H TG + + LD E
Sbjct: 1153 PKDVSVVQIEAFDPDS--SSNDKLMYKITSGNPQGFFSI----HPKTGLITTTSRKLDRE 1206
Query: 523 TAAVSNI-VFKAENPEPLVFGVKYNASSFAKFTLIVTDVNE-APQFSQHVFQAKVSEDV- 579
+ V +N P S+ A+ + + D N+ PQF Q ++ ++ E
Sbjct: 1207 QQDEHILEVTVTDNGSP-------PKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREK 1259
Query: 580 ------AIGTKVGNVTAKDPE---GLDISYSLR-GDTRGWLKIDHVTGEIFSVAPLDREA 629
A + +V A D + +ISYS+ G+ G I+ TG + S A
Sbjct: 1260 PDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSS--KRFSAA 1317
Query: 630 GSPYRVQVVATEVGGSSLSSVSEFHL 655
G + + A + G SS + H+
Sbjct: 1318 GEYDILSIKAVDNGRPQKSSTTRLHI 1343
Score = 124 bits (312), Expect = 3e-28
Identities = 150/642 (23%), Positives = 280/642 (43%), Gaps = 66/642 (10%)
Query: 35 TFSIYEGQEPSQIIFQFKANPPAVT--FELTGET-DNIFVIER-EGLLYYNRALDRETRS 90
TF++ E + +I PP + F++TG D+ F +++ G + + LD E +S
Sbjct: 1364 TFTVMESDPVAHMIGVISVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKS 1423
Query: 91 THNLQVAALDANGIIVEGPVPITIKVKDINDNRPTFLQSKYEGSVRQNSRPGKPFLYVNA 150
+NL V A D I+ + IKV D ND+RP F SKYE + +++ P L ++A
Sbjct: 1424 NYNLTVEATDGTTTIL---TQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISA 1480
Query: 151 TDLDDPATPNGQLYYQIVIQLPMINNVMYFQINNKTGAISLTREGSQELNPAKNPSYNLV 210
D D+ N +Y + P+ ++ F+++ TG++ S++L+ + L
Sbjct: 1481 VDQDE---KNKLIYTLQSSRDPL--SLKKFRLDPATGSLYT----SEKLDHEAVHQHTLT 1531
Query: 211 ISVKDMGGQSENSF-------SDTTSVDIIVTENIWKAPKPVEMVENSTDPHPIKITQVR 263
+ V+D + +F SDT T + +K S + + +
Sbjct: 1532 VMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDK 1591
Query: 264 WNDPGAQYSLVDKEKLPRFPFSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSY 322
+ YS ++ + F ID G I + LDR + Y A D+ P+S
Sbjct: 1592 GKNAEVLYS-IESGNIGN-SFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSE 1649
Query: 323 PLEIHVKVKDINDNPPTCPSPVTVFEVQENERLGNSIGTLTAHDRDEENTANSFLNYRIV 382
+ + V ++ P S E+ E +G+ +G +TAH + +V
Sbjct: 1650 ITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHSQSS-----------VV 1698
Query: 383 EQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTPQYNLTIEVSD-KDFKTLCFVQINVID 441
+ F I ++G + + +++L + P Y L I+ ++ T V +++ D
Sbjct: 1699 YEIKDGNTGDAFDINPHSGTI-ITQKALDFETLPIYTLIIQGTNMAGLSTNTTVLVHLQD 1757
Query: 442 INDQIPIFEKSDYGNLTLAEDTNIGSTILT-------IQATDADEPFTGSSKILYHIIKG 494
ND P+F +++Y L ++E +I S +LT I+A DAD+ ++ ++YHI++
Sbjct: 1758 ENDNAPVFMQAEYTGL-ISESASINSVVLTDRNVPLVIRAADADK--DSNALLVYHIVEP 1814
Query: 495 DSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVSNIVFKAEN-PEPLVFGVKYNASSFAKF 553
+D ++TG + LD+E ++ + + + P +F A A
Sbjct: 1815 SVHTYFAID----SSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLF-----AEYAANV 1865
Query: 554 TLIVTDVNEAPQ-FSQHVFQAKVSEDVAIGTKVGNVTAKDPEGLDISYSLRGDTRGWL-- 610
T+ V D+N+ P F++ +++A + G KV V A D + S + T G +
Sbjct: 1866 TVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGE 1925
Query: 611 --KIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSLSSV 650
+D+ TG + + S Y + V A++ + L+SV
Sbjct: 1926 KFSMDYKTGAL--TVQNTTQLRSRYELTVRASDGRFAGLTSV 1965
Score = 87.4 bits (215), Expect = 5e-17
Identities = 105/428 (24%), Positives = 177/428 (41%), Gaps = 69/428 (16%)
Query: 34 MTFSIYEGQEPSQIIFQFKANPPAVTFELTGETDNIFVIEREGLLYYNRALDRETRSTHN 93
+T+SI G E + F + +T +F+IE LD E+ +
Sbjct: 3265 ITYSIISGNEHGK-------------FSIDSKTGAVFIIEN---------LDYESSHEYY 3302
Query: 94 LQVAALDANGIIVEGPVPITIKVKDINDNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDL 153
L V A D + + + V DINDN P F Q Y + +++ + + V A D
Sbjct: 3303 LTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDA 3362
Query: 154 DDPATPNGQLYYQIVIQLPMINNVMYFQINNKTGAISLTREGSQELNPAKNPSYNLVISV 213
D P+ N ++Y I+ N F I+ G + +T+ +E Y L +
Sbjct: 3363 DGPS--NSHIHYSIIDG----NQGSSFTIDPVRGEVKVTKLLDRETISG----YTLTVQA 3412
Query: 214 KDMGGQSENSFSDTTSVDIIVTENIWKAPK----PVEMVENSTDPHPIKITQV------- 262
D G +TT+V+I V++ AP ++ P + Q+
Sbjct: 3413 SDNGSPPR---VNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDS 3469
Query: 263 RWNDPGAQYSLV--DKEKLPRFPFSIDQEGDIYVTQPLDREEKDAYVFYAVAKDEYGKP- 319
N P +++V + EK F ++ +G + + + R+EKD Y+ D GKP
Sbjct: 3470 SHNGPPFFFTIVTGNDEKA----FEVNPQGVLLTSSAIKRKEKDHYLLQVKVADN-GKPQ 3524
Query: 320 LSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERL-GNSIGTLTAHDRDEENTANSFLN 378
LS I ++V + + PP P+ +F E G IG + A D+D +T L
Sbjct: 3525 LSSLTYIDIRVIEESIYPPAI-LPLEIFITSSGEEYSGGVIGKIHATDQDVYDT----LT 3579
Query: 379 YRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTPQYNLTIEVSDKDFKTLCFVQIN 438
Y + Q MD LF + + G L + KK D QY L + V+D F T+ + ++
Sbjct: 3580 YSLDPQ-----MDNLFSVSSTGGKL----IAHKKLDIGQYLLNVSVTDGKFTTVADITVH 3630
Query: 439 VIDINDQI 446
+ + ++
Sbjct: 3631 IRQVTQEM 3638
Score = 80.9 bits (198), Expect = 5e-15
Identities = 132/564 (23%), Positives = 222/564 (39%), Gaps = 97/564 (17%)
Query: 207 YNLVISVKDMGGQSENSFSDTTSVDII-VTENIWKA-----PKPVEMVENSTDPHP-IKI 259
YNL + KD G + S SV +I VT +KA K V E S P +
Sbjct: 332 YNLTLQAKDKGTPPQFS-----SVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPV 386
Query: 260 TQVRWNDPGAQYSLVDKEKLPRFPFSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYGK 318
V+ + V K + FS++ G I + +P+ R++ + D
Sbjct: 387 VMVKAIPAYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDRKAS 446
Query: 319 PLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERLGNSIGTLTAHDRDEENTANSFLN 378
++ VKV N NPP EN +G ++ +L+A D DE N ++
Sbjct: 447 T-----KVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGE--NGYVT 499
Query: 379 YRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTPQ-YNLTIEVSD------KDFKT 431
Y I +P F I + G + ++L + P+ Y L I SD ++ +
Sbjct: 500 YSIANLN-HVP----FAIDHFTGAVS-TSENLDYELMPRVYTLRIRASDWGLPYRREVEV 553
Query: 432 LCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQATDADEPFTGSSKILYHI 491
L + +N ++ND P+FEK + T+ D +G I T+ A DADE + Y I
Sbjct: 554 LATITLN--NLNDNTPLFEKINCEG-TIPRDLGVGEQITTVSAIDADE----LQLVQYQI 606
Query: 492 IKGDSEGRLGVDTDPHTNTGYVIIKKPL-DFETAAVS--NIVFKAENPEPLVFGVKYNAS 548
G+ + + N+G + +K+ L D A VS ++ A + E + N +
Sbjct: 607 EAGNELDFFSL----NPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINIT 662
Query: 549 SFAKFTLIVTDVNE---APQFSQHVFQA-------------------------------- 573
A L+ E A ++ + QA
Sbjct: 663 VAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPT 722
Query: 574 --KVSEDVAIGTKVGNVTAKDPEGLDISYSLR-------GDTRGWLKIDHVTGEIFSVAP 624
+V E+ +G+ V + + D LD ++ + G+ ID TG + ++P
Sbjct: 723 GIQVKENQPVGSSVIFMNSTD---LDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSP 779
Query: 625 LDREAGSPYRVQVVATEVGGSSLSSVSEFHLILMDVNDNPPRLAKDYTGLFFCHPLSAPG 684
LDRE Y + + ++G ++ H++++D NDNPP ++ +
Sbjct: 780 LDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHS 839
Query: 685 SLI-FEATDDDQHLFRGPHFTFSL 707
+I EATD D L H T+S+
Sbjct: 840 EIIQVEATDKD--LGPNGHVTYSI 861
Score = 73.6 bits (179), Expect = 7e-13
Identities = 126/533 (23%), Positives = 208/533 (39%), Gaps = 57/533 (10%)
Query: 84 LDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNRPTFLQSKYEGSVRQNSRPGK 143
L+RE + + L V AL+ N VE + ++V D ND RP F + Y S+ +N+
Sbjct: 108 LNREVKDHYTLIVKALEKN-TNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRT 166
Query: 144 PFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQINNKTGAISLTREGSQELNPAK 203
V+ATD D NG+ YY + M F I+ +G I LT L+ +
Sbjct: 167 SIARVSATDAD--IGTNGEFYYSFKDRTDM------FAIHPTSGVIVLT----GRLDYLE 214
Query: 204 NPSYNLVISVKDMG----GQSENSFSDTTSVDIIVTENIWKAPKPVEMVENSTDPHP-IK 258
Y + I D G G S S +V I V + + D P
Sbjct: 215 TKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELDRDPAYA 274
Query: 259 ITQVRWNDPG-----AQYSLVDKEKLPRF----PFSIDQEGDIYVTQPLDREEKD-AYVF 308
I V D G A S+V + L +F F +E + +D + Y
Sbjct: 275 IVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNL 334
Query: 309 YAVAKDEYGKP-LSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERLGNSIGTLTAHDR 367
AKD+ P S IHV P V E+ E + + A
Sbjct: 335 TLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKA--- 391
Query: 368 DEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTPQYNLTIEVSDK 427
A S L Y + + TP F + G++ + + +K+Q + L + SD+
Sbjct: 392 ---IPAYSHLRY-VFKSTPG---KAKFSLNYNTGLISIL-EPVKRQQAAHFELEVTTSDR 443
Query: 428 DFKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQATDADEPFTGSSKI 487
T V + V+ N P F ++ Y E+ IG+T++++ A D DE G +
Sbjct: 444 KASTK--VLVKVLGANSNPPEFTQTAY-KAAFDENVPIGTTVMSLSAVDPDE---GENGY 497
Query: 488 LYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFE-TAAVSNIVFKAENPEPLVFGVKYN 546
+ + I + +D TG V + LD+E V + +A + +G+ Y
Sbjct: 498 VTYSIANLNHVPFAID----HFTGAVSTSENLDYELMPRVYTLRIRASD-----WGLPYR 548
Query: 547 ASSFAKFTLIVTDVNE-APQFSQHVFQAKVSEDVAIGTKVGNVTAKDPEGLDI 598
T+ + ++N+ P F + + + D+ +G ++ V+A D + L +
Sbjct: 549 REVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQL 601
Score = 47.4 bits (111), Expect = 6e-05
Identities = 46/173 (26%), Positives = 73/173 (42%), Gaps = 24/173 (13%)
Query: 45 SQIIFQFKANPPAVTFELTGETDNIFVIEREGLLYYNRALDRETRSTHNLQVAALDANGI 104
S + + FK+ P F L T I ++E + R+ + L+V D
Sbjct: 396 SHLRYVFKSTPGKAKFSLNYNTGLISILE---------PVKRQQAAHFELEVTTSDR--- 443
Query: 105 IVEGPVPITIKVKDINDNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLY 164
+ + +KV N N P F Q+ Y+ + +N G + ++A D D+ NG +
Sbjct: 444 --KASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDE--GENGYVT 499
Query: 165 YQIVIQLPMINNVMYFQINNKTGAISLTREGSQELNPAKNPSYNLVISVKDMG 217
Y I +N+V F I++ TGA+S + EL P Y L I D G
Sbjct: 500 YSIA----NLNHVP-FAIDHFTGAVSTSENLDYELMPR---VYTLRIRASDWG 544
Score = 42.4 bits (98), Expect = 0.002
Identities = 93/471 (19%), Positives = 180/471 (38%), Gaps = 42/471 (8%)
Query: 295 TQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENER 354
T L+RE KD Y A ++ + ++ V+V D ND P + EN
Sbjct: 105 TAILNREVKDHYTLIVKALEK-NTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTA 163
Query: 355 LGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQD 414
+ SI ++A D D + +++ +F I +G++ L + L +
Sbjct: 164 IRTSIARVSATDADIGTNGEFYYSFK--------DRTDMFAIHPTSGVIVLTGR-LDYLE 214
Query: 415 TPQYNLTIEVSDKDFK--------TLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIG 466
T Y + I +D+ K ++ + +++ N+ P+ L D +
Sbjct: 215 TKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSEL--DRDPA 272
Query: 467 STILTIQATDADEPFTGSSKILYHIIKGDSEGRL-GVDTDPHTNTGYVIIKKPLDFETAA 525
I+T+ D D+ G L I+ GD + V + P + V +D+++
Sbjct: 273 YAIVTVD--DCDQGANGDIASL-SIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHP 329
Query: 526 VS-NIVFKAENPEPLVFGVKYNASSFAKFTLIVTDVNEAP-QFSQHVFQAKVSEDVAIGT 583
N+ +A++ G SS + P +F + V++A++SE T
Sbjct: 330 FGYNLTLQAKDK-----GTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNT 384
Query: 584 KVGNVTAKDPEGLDISYSLRGDT-RGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEV 642
V V A P + Y + + +++ TG I + P+ R+ + + ++V ++
Sbjct: 385 PVVMVKA-IPAYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDR 443
Query: 643 GGSSLSSVSEFHLILMDVNDNPPRLAKD-YTGLFFCHPLSAPGSLIFEATDDDQHLFRGP 701
S+ V ++ N NPP + Y F + + A D D+
Sbjct: 444 KASTKVLVK-----VLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEG--ENG 496
Query: 702 HFTFSLGSGSLQNDWEVSKINGTHARLSTRHTEFEEREYVVLIRINDGGRP 752
+ T+S+ + + + + G + E R Y + IR +D G P
Sbjct: 497 YVTYSIANLN-HVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLP 546
>gi|16306530 cadherin 10, type 2 preproprotein [Homo sapiens]
Length = 788
Score = 207 bits (527), Expect = 3e-53
Identities = 164/557 (29%), Positives = 272/557 (48%), Gaps = 40/557 (7%)
Query: 284 FSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYG-KPLSYPLEIHVKVKDINDNPPTCP 341
F ID++ GDI+ T+ +DREEK Y A A + +P+ E +K+ DINDN PT P
Sbjct: 102 FIIDEKTGDIHATRRIDREEKAFYTLRAQAINRRTLRPVEPESEFVIKIHDINDNEPTFP 161
Query: 342 SPVTVFEVQENERLGNSIGTLTAHDRDEENTANSF-LNYRIVEQTPKLPMDGLFLIQTYA 400
+ V E +G S+ +TA D D+ + NS + Y I++ P F ++
Sbjct: 162 EEIYTASVPEMSVVGTSVVQVTATDADDPSYGNSARVIYSILQGQP------YFSVEPET 215
Query: 401 GMLQLAKQSLKKQDTPQYNLTIEVSDKD-----FKTLCFVQINVIDINDQIPIFEKSDYG 455
G+++ A ++ +++ QY + I+ D V I + D+ND P F ++
Sbjct: 216 GIIRTALPNMNRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQNTI- 274
Query: 456 NLTLAEDTNIGSTILTIQATDADEPFTG-SSKILYHIIKGDSEGRLGVDTDPHTNTGYVI 514
+L + E + +G+ I +++ATDAD TG ++++ Y II GD + T+ T G +
Sbjct: 275 HLRVLESSPVGTAIGSVKATDAD---TGKNAEVEYRIIDGDGTDMFDIVTEKDTQEGIIT 331
Query: 515 IKKPLDFETAAVSNIVFKAENPEPLVFGVKYNASSFAKFTLI---VTDVNEAPQFSQHVF 571
+KKPLD+E+ + + +AEN V Y F T++ + DV+E P FS+ +
Sbjct: 332 VKKPLDYESRRLYTLKVEAENTH--VDPRFYYLGPFKDTTIVKISIEDVDEPPVFSRSSY 389
Query: 572 QAKVSEDVAIGTKVGNVTAKDPEGLD--ISYSL--RGDTRGWLKIDHVTGEIFSVAPLDR 627
+V ED+ +GT +G V A+DP+ + I +SL D I G +++ PLDR
Sbjct: 390 LFEVHEDIEVGTIIGTVMARDPDSISSPIRFSLDRHTDLDRIFNIHSGNGSLYTSKPLDR 449
Query: 628 EAGSPYRVQVVATEVGGSSLSSVSEFHLILMDVNDNPPRLAKDYTGLFFCHPLSAPGSLI 687
E + + V+A E+ ++ + ++DVNDN P+ A Y F C + PG LI
Sbjct: 450 ELSQWHNLTVIAAEINNPKETTRVAVFVRILDVNDNAPQFAVFY-DTFVCEN-ARPGQLI 507
Query: 688 --FEATDDDQHLFRGPHFTFSLGSGSLQNDWEVSKINGTHARLSTRHTEFEERE---YVV 742
A D D L G F FSL ++ ++ V AR+ TR F E Y++
Sbjct: 508 QTISAVDKDDPL-GGQKFFFSL--AAVNPNFTVQDNEDNTARILTRKNGFNRHEISTYLL 564
Query: 743 LIRINDGGRPPLEGIVSLPVTFCSCVEGSCFRPAGHQTGIPTVGMAVGILLTTLLVIGII 802
+ I+D P +L + C+C + + + G++ G L+ LL I I+
Sbjct: 565 PVVISDNDYPIQSSTGTLTIRVCACDSQGNMQSCSAEALLLPAGLSTGALIAILLCIIIL 624
Query: 803 LAVV--FIRIKKDKGKD 817
L +V F +K+ + K+
Sbjct: 625 LVIVVLFAALKRQRKKE 641
Score = 145 bits (367), Expect = 1e-34
Identities = 130/454 (28%), Positives = 216/454 (47%), Gaps = 47/454 (10%)
Query: 57 AVTFELTGE-TDNIFVI-EREGLLYYNRALDRETRSTHNLQVAALDANGII-VEGPVPIT 113
++ + L+G+ +F+I E+ G ++ R +DRE ++ + L+ A++ + VE
Sbjct: 88 SLKYILSGDGAGTLFIIDEKTGDIHATRRIDREEKAFYTLRAQAINRRTLRPVEPESEFV 147
Query: 114 IKVKDINDNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPN-GQLYYQIVIQLP 172
IK+ DINDN PTF + Y SV + S G + V ATD DDP+ N ++ Y I+ P
Sbjct: 148 IKIHDINDNEPTFPEEIYTASVPEMSVVGTSVVQVTATDADDPSYGNSARVIYSILQGQP 207
Query: 173 MINNVMYFQINNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDI 232
YF + +TG I R +N Y +VI KDMGGQ S TT+V+I
Sbjct: 208 ------YFSVEPETGII---RTALPNMNRENREQYQVVIQAKDMGGQM-GGLSGTTTVNI 257
Query: 233 IVTENIWKAPK------PVEMVENSTDPHPIKITQVRWNDPG----AQYSLVDKEKLPRF 282
+T+ P+ + ++E+S I + D G +Y ++D + F
Sbjct: 258 TLTDVNDNPPRFPQNTIHLRVLESSPVGTAIGSVKATDADTGKNAEVEYRIIDGDGTDMF 317
Query: 283 PFSID---QEGDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLE-------IHVKVKD 332
+ QEG I V +PLD E + Y A++ + P Y L + + ++D
Sbjct: 318 DIVTEKDTQEGIITVKKPLDYESRRLYTLKVEAENTHVDPRFYYLGPFKDTTIVKISIED 377
Query: 333 INDNPPTCPSPVTVFEVQENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDG 392
+ D PP +FEV E+ +G IGT+ A D D + +S + + + T +D
Sbjct: 378 V-DEPPVFSRSSYLFEVHEDIEVGTIIGTVMARDPD---SISSPIRFSLDRHT---DLDR 430
Query: 393 LFLIQTYAGMLQLAKQSLKKQDTPQYNLTI---EVSDKDFKTLCFVQINVIDINDQIPIF 449
+F I + G L +K L ++ + +NLT+ E+++ T V + ++D+ND P F
Sbjct: 431 IFNIHSGNGSLYTSK-PLDRELSQWHNLTVIAAEINNPKETTRVAVFVRILDVNDNAPQF 489
Query: 450 EKSDYGNLTLAEDTNIGSTILTIQATDADEPFTG 483
+ + + + E+ G I TI A D D+P G
Sbjct: 490 --AVFYDTFVCENARPGQLIQTISAVDKDDPLGG 521
>gi|4826669 cadherin 15 preproprotein [Homo sapiens]
Length = 814
Score = 206 bits (525), Expect = 6e-53
Identities = 173/611 (28%), Positives = 279/611 (45%), Gaps = 37/611 (6%)
Query: 232 IIVTENIWKAPKPVEMVENSTDPHPIKITQVRWNDPGAQYSLVDKEKLPRFPFSIDQ-EG 290
I V+EN + P P +V+ +D + PG VD+E PR FSID+ G
Sbjct: 52 ISVSENHKRLPYP--LVQIKSDKQQLGSVIYSIQGPG-----VDEE--PRGVFSIDKFTG 102
Query: 291 DIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQ 350
+++ LDRE+ D + A A D G L P ++ + V D NDN P V
Sbjct: 103 KVFLNAMLDREKTDRFRLRAFALDLGGSTLEDPTDLEIVVVDQNDNRPAFLQEAFTGRVL 162
Query: 351 ENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQ-TPKLPMDGLFLIQTYAGMLQLAKQS 409
E G + A D D+ T N+ L + I++Q +P+L F I G ++ +
Sbjct: 163 EGAVPGTYVTRAEATDADDPETDNAALRFSILQQGSPEL-----FSIDELTGEIRTVQVG 217
Query: 410 LKKQDTPQYNLTIEVSDKDFKTLCFVQINVI---DINDQIPIFEKSDYGNLTLAEDTNIG 466
L ++ YNLT++V+D L +I DIND P F + ++ A + G
Sbjct: 218 LDREVVAVYNLTLQVADMSGDGLTATASAIITLDDINDNAPEFTRDEF--FMEAIEAVSG 275
Query: 467 STILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAV 526
+ ++ D D P + + + I++GD +G+ + TDP TN G + I K LD+E+
Sbjct: 276 VDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDYESCEH 335
Query: 527 SNIVFKAENPEPLVFGVKYNASSFAKFTLIVTDVNEAPQFSQHVFQAKVSEDVAIGTKVG 586
+ +N PL AK + V D NE P F ++ + ++E GT V
Sbjct: 336 YELKVSVQNEAPLQAAALRAERGQAKVRVHVQDTNEPPVFQENPLRTSLAEGAPPGTLVA 395
Query: 587 NVTAKDPEGLD---ISYSLRGDTRGWLKIDHVTGEIFSVAPLDREA----GSPYRVQVVA 639
+A+DP+ +SYS D WL++D TG I + L + G YR V+A
Sbjct: 396 TFSARDPDTEQLQRLSYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKGGWYRAIVLA 455
Query: 640 TEVGGSSLSSVSEFHLILMDVNDNPPRLAKDYTGLFFCHPLSAPGSLIFEATDDDQHLFR 699
+ ++ + +++VND+ P LA G P PG L+ ATD+D
Sbjct: 456 QDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQGPG-LLLGATDEDLPPHG 514
Query: 700 GP-HFTFSLGSGSLQNDWEVSKINGTHARLSTRHTEFEEREYVVLIRINDGGRPPLEGIV 758
P HF S L +W +S++N +HARL RH + E + + + + D G+PP +
Sbjct: 515 APFHFQLSPRLPELGRNWSLSQVNVSHARLRPRH-QVPEGLHRLSLLLRDSGQPPQQREQ 573
Query: 759 SLPVTFCSCVEGSCFRPAGHQTGIPTVGMAVG---ILLTTLLVIGIILAVVFIRI---KK 812
L VT C C + P G+++G I+L + L++ +++ +V +R K+
Sbjct: 574 PLNVTVCRCGKDGVCLPGAAALLAGGTGLSLGALVIVLASALLLLVLVLLVALRARFWKQ 633
Query: 813 DKGKDNVESAQ 823
+GK + Q
Sbjct: 634 SRGKGLLHGPQ 644
Score = 95.5 bits (236), Expect = 2e-19
Identities = 112/442 (25%), Positives = 181/442 (40%), Gaps = 38/442 (8%)
Query: 65 ETDNIFVIER-EGLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNR 123
E +F I++ G ++ N LDRE L+ ALD G +E P + I V D NDNR
Sbjct: 90 EPRGVFSIDKFTGKVFLNAMLDREKTDRFRLRAFALDLGGSTLEDPTDLEIVVVDQNDNR 149
Query: 124 PTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQIN 183
P FLQ + G V + + PG ATD DDP T N L + I+ Q + F I+
Sbjct: 150 PAFLQEAFTGRVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQ----GSPELFSID 205
Query: 184 NKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTENIWKAPK 243
TG I + G L+ YNL + V DM G + + + +N + +
Sbjct: 206 ELTGEIRTVQVG---LDREVVAVYNLTLQVADMSGDGLTATASAIITLDDINDNAPEFTR 262
Query: 244 PVEMVENSTDPHPIKITQVRWND---PG-----AQYSLVDKEKLPRFPFSID---QEGDI 292
+E + + ++ D PG A++++++ + +F D EG +
Sbjct: 263 DEFFMEAIEAVSGVDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVL 322
Query: 293 YVTQPLDREEKDAYVFYAVAKDEYGKPLSY--------PLEIHVKVKDINDNPPTCPSPV 344
+ + LD E + Y ++E PL ++ V V+D N+ P +P+
Sbjct: 323 SIVKALDYESCEHYELKVSVQNE--APLQAAALRAERGQAKVRVHVQDTNEPPVFQENPL 380
Query: 345 TVFEVQENERLGNSIGTLTAHDRDEENTANSFLNY-RIVEQTPKLPMDGLF-LIQTYAGM 402
+ E G + T +A D D E L+Y + + L +D IQT +
Sbjct: 381 RT-SLAEGAPPGTLVATFSARDPDTEQLQR--LSYSKDYDPEDWLQVDAATGRIQT-QHV 436
Query: 403 LQLAKQSLKKQDTPQYNLTIEVSDKDFKTLCFVQINVIDINDQIPIFEKSDYGNLTLAED 462
L A LK L + + + + I ++++ND P+ G+L
Sbjct: 437 LSPASPFLKGGWYRAIVLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPH 496
Query: 463 TNIGSTILTIQATDADEPFTGS 484
G L + ATD D P G+
Sbjct: 497 QGPG---LLLGATDEDLPPHGA 515
>gi|29570800 cadherin-like 26 isoform a [Homo sapiens]
Length = 832
Score = 206 bits (523), Expect = 9e-53
Identities = 159/545 (29%), Positives = 256/545 (46%), Gaps = 35/545 (6%)
Query: 284 FSID--QEGDIYVTQPLDREEKDAY-VFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTC 340
FS++ + G IYV +P+DRE ++ V++ V + GK + L ++++ D+ND+ P
Sbjct: 106 FSLEDHENGRIYVHRPVDREMTPSFTVYFDVVERSTGKIVDTSLIFNIRISDVNDHAPQF 165
Query: 341 PSPVTVFEVQENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYA 400
P VQEN+ G I + A D DEENT NS + Y ++ QTP L G F + +
Sbjct: 166 PEKEFNITVQENQSAGQPIFQMLAVDLDEENTPNSQVLYFLISQTPLLKESG-FRVDRLS 224
Query: 401 GMLQLAKQSLKKQDTPQYNLTIEVSD---KDFKTLCFVQINVIDINDQIPIFEKSDYGNL 457
G ++L+ L + PQ+ L I D + V ++V + N+ P F + +Y
Sbjct: 225 GEIRLS-GCLDYETAPQFTLLIRARDCGEPSLSSTTTVHVDVQEGNNHRPAFTQENY--K 281
Query: 458 TLAEDTNIGSTILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKK 517
+ +L + D D PFT + + ++I+ G+ EG + TDP TN G + + K
Sbjct: 282 VQIPEGRASQGVLRLLVQDRDSPFTSAWRAKFNILHGNEEGHFDISTDPETNEGILNVIK 341
Query: 518 PLDFETAAVSNIVFKAENPEPLVFGVK------YNASSFAKFTLIVTDVNEAPQFSQHVF 571
PLD+ET +++ EN E LVF + A++ A ++ VTD N+ P F F
Sbjct: 342 PLDYETRPAQSLIIVVENEERLVFCERGKLQPPRKAAASATVSVQVTDANDPPAFHPQSF 401
Query: 572 QAKVSEDVAIGTKVGNVTAKDPEGLDISYSLRGDTRGWLKIDHVTGEIFSVAPLDREA-- 629
E GT +G A DP+ I Y L D W+ +D +G + +V P+DRE+
Sbjct: 402 IVNKEEGARPGTLLGTFNAMDPDS-QIRYELVHDPANWVSVDKNSGVVITVEPIDRESPH 460
Query: 630 --GSPYRVQVVATEVGGSSLSSVSEFHLILMDVNDNPPRLAKDYTGLFFCHPLSAPGSLI 687
S Y + + A + G ++ L L D+NDN P L + C + L
Sbjct: 461 VNNSFYVIIIHAVDDGFPPQTATGTLMLFLSDINDNVPTLRPRSRYMEVCES-AVHEPLH 519
Query: 688 FEATDDDQHLFRGPHFTFSLGS--GSLQNDWEVSKINGTHARLSTRHTEFEEREYVVLIR 745
EA D D F P FTF L + G+ ++ W++ + G L T + Y+V +
Sbjct: 520 IEAEDPDLEPFSDP-FTFELDNTWGNAEDTWKLGRNWGQSVELLTLRS-LPRGNYLVPLF 577
Query: 746 INDGGRPPLEGIVSLPVTFCSCVEG-SCFRPAGHQTGIPTVGMAVGILLTTLLV-IGIIL 803
I D + L ++ V C C G +C A + VG+ VG L + + +
Sbjct: 578 IGD--KQGLSQKQTVHVRICPCASGLTCVELADAE-----VGLHVGALFPVCAAFVALAV 630
Query: 804 AVVFI 808
A++F+
Sbjct: 631 ALLFL 635
Score = 96.3 bits (238), Expect = 1e-19
Identities = 83/322 (25%), Positives = 146/322 (45%), Gaps = 36/322 (11%)
Query: 76 GLLYYNRALDRETRSTHNLQVAALD-ANGIIVEGPVPITIKVKDINDNRPTFLQSKYEGS 134
G +Y +R +DRE + + ++ + G IV+ + I++ D+ND+ P F + ++ +
Sbjct: 114 GRIYVHRPVDREMTPSFTVYFDVVERSTGKIVDTSLIFNIRISDVNDHAPQFPEKEFNIT 173
Query: 135 VRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQINNKTGAISLTRE 194
V++N G+P + A DLD+ TPN Q+ Y ++ Q P++ F+++ +G I L+
Sbjct: 174 VQENQSAGQPIFQMLAVDLDEENTPNSQVLYFLISQTPLLKE-SGFRVDRLSGEIRLS-- 230
Query: 195 GSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTENIWKAPK------PVEMV 248
G + A P + L+I +D G E S S TT+V + V E P V++
Sbjct: 231 GCLDYETA--PQFTLLIRARDCG---EPSLSSTTTVHVDVQEGNNHRPAFTQENYKVQIP 285
Query: 249 ENSTDPHPIKITQVRWNDP-----GAQYSLVDKEKLPRFPFSID---QEGDIYVTQPLDR 300
E +++ + P A+++++ + F S D EG + V +PLD
Sbjct: 286 EGRASQGVLRLLVQDRDSPFTSAWRAKFNILHGNEEGHFDISTDPETNEGILNVIKPLDY 345
Query: 301 EEKDAYVFYAVAKDEY------------GKPLSYPLEIHVKVKDINDNPPTCPSPVTVFE 348
E + A V ++E + + + V+V D ND P P V
Sbjct: 346 ETRPAQSLIIVVENEERLVFCERGKLQPPRKAAASATVSVQVTDANDPPAFHPQSFIV-N 404
Query: 349 VQENERLGNSIGTLTAHDRDEE 370
+E R G +GT A D D +
Sbjct: 405 KEEGARPGTLLGTFNAMDPDSQ 426
>gi|16306532 cadherin 11, type 2 preproprotein [Homo sapiens]
Length = 796
Score = 204 bits (520), Expect = 2e-52
Identities = 172/598 (28%), Positives = 274/598 (45%), Gaps = 45/598 (7%)
Query: 247 MVENSTDPHPIKI----TQVRWNDPGAQYSLVDKEKLPRFPFSIDQEGDIYVTQPLDREE 302
++E T P P+ + + + D +Y L + F D+ G+I+ T+ LDREE
Sbjct: 62 VIEEYTGPDPVLVGRLHSDIDSGDGNIKYILSGEGAGTIFVID-DKSGNIHATKTLDREE 120
Query: 303 KDAYVFYAVAKD-EYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERLGNSIGT 361
+ Y A A D + +PL P E VKV+DINDNPP V E +G S+
Sbjct: 121 RAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQ 180
Query: 362 LTAHDRDEENTANSF-LNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTPQYNL 420
+TA D D+ NS L Y I+E P F ++ G+++ A ++ ++ +Y++
Sbjct: 181 VTASDADDPTYGNSAKLVYSILEGQP------YFSVEAQTGIIRTALPNMDREAKEEYHV 234
Query: 421 TIEVSDKD-----FKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQAT 475
I+ D V I + D+ND P F +S Y ++++E G + ++A
Sbjct: 235 VIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQSVY-QMSVSEAAVPGEEVGRVKAK 293
Query: 476 DADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVSNIVFKAEN 535
D D G + Y+I+ GD + TD T G + +KKP+DFET ++ +A N
Sbjct: 294 DPDIGENGL--VTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAAN 351
Query: 536 PEPLVFGVKYNASSFAKFTLIVT----DVNEAPQFSQHVFQAKVSEDVAIGTKVGNVTAK 591
K+ ++ K T+ V D +E P F + +V E+ A GT VG V AK
Sbjct: 352 VH---IDPKFISNGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAK 408
Query: 592 DPEGLD--ISYSL--RGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSL 647
DP+ + I YS+ D + I+ G I + PLDRE + + V A E+
Sbjct: 409 DPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAAEIHNRHQ 468
Query: 648 SSVSEFHLILMDVNDNPPRLAKDYTGLFFCH-----PLSAPGSLIFEATDDDQHLFRGPH 702
+ + ++DVNDN P+ A Y G F C PLS + A D D GP
Sbjct: 469 EAKVPVAIRVLDVNDNAPKFAAPYEG-FICESDQTKPLSNQPIVTISADDKDDTA-NGPR 526
Query: 703 FTFSLGSGSLQN-DWEVSKINGTHARLSTRHTEFEERE---YVVLIRINDGGRPPLEGIV 758
F FSL + N ++ V A + R F ++ Y++ I I+DGG PP+
Sbjct: 527 FIFSLPPEIIHNPNFTVRDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGGIPPMSSTN 586
Query: 759 SLPVTFCSCVEGSCFRPAGHQTGIPTVGMAVGILLTTL--LVIGIILAVVFIRIKKDK 814
+L + C C + I G++ G L+ L +VI +++ V+F+ +++ K
Sbjct: 587 TLTIKVCGCDVNGALLSCNAEAYILNAGLSTGALIAILACIVILLVIVVLFVTLRRQK 644
Score = 154 bits (390), Expect = 2e-37
Identities = 138/455 (30%), Positives = 211/455 (46%), Gaps = 47/455 (10%)
Query: 58 VTFELTGE-TDNIFVIE-REGLLYYNRALDRETRSTHNLQVAALDAN-GIIVEGPVPITI 114
+ + L+GE IFVI+ + G ++ + LDRE R+ + L A+D + +E P +
Sbjct: 88 IKYILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIV 147
Query: 115 KVKDINDNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPN-GQLYYQIVIQLPM 173
KV+DINDN P FL Y +V + S G + V A+D DDP N +L Y I+ P
Sbjct: 148 KVQDINDNPPEFLHETYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQP- 206
Query: 174 INNVMYFQINNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDII 233
YF + +TG I R ++ Y++VI KDMGG S TT V I
Sbjct: 207 -----YFSVEAQTGII---RTALPNMDREAKEEYHVVIQAKDMGGHM-GGLSGTTKVTIT 257
Query: 234 VT---ENIWKAPKPVEMVENSTDPHP-IKITQVRWNDPG------AQYSLVDKEKLPRFP 283
+T +N K P+ V + S P ++ +V+ DP Y++VD + + F
Sbjct: 258 LTDVNDNPPKFPQSVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFE 317
Query: 284 FSID---QEGDIYVTQPLDREEKDAYVFYAVAKDEY-------GKPLSYPLEIHVKVKDI 333
+ D QEG I + +P+D E K AY A + + P + + + V+D
Sbjct: 318 ITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFISNGPFKDTVTVKISVEDA 377
Query: 334 NDNPPTCPSPVTVFEVQENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGL 393
D PP +P + EVQEN G +G + A D D ANS + Y I T +D
Sbjct: 378 -DEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPD---AANSPIRYSIDRHT---DLDRF 430
Query: 394 FLIQTYAGMLQLAKQSLKKQDTPQYNLTI---EVSDKDFKTLCFVQINVIDINDQIPIFE 450
F I G ++ K L +++T N+T+ E+ ++ + V I V+D+ND P F
Sbjct: 431 FTINPEDGFIKTTK-PLDREETAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFA 489
Query: 451 KSDYGNLTLAEDTN--IGSTILTIQATDADEPFTG 483
G + ++ T I+TI A D D+ G
Sbjct: 490 APYEGFICESDQTKPLSNQPIVTISADDKDDTANG 524
>gi|4826702 desmocollin 1 isoform Dsc1b preproprotein [Homo sapiens]
Length = 840
Score = 203 bits (516), Expect = 6e-52
Identities = 170/592 (28%), Positives = 268/592 (45%), Gaps = 44/592 (7%)
Query: 241 APKPVEMVENSTDPHPIKITQVRWNDPGAQYSL--------VDKEKLPRFPFSIDQEGDI 292
AP P ++ENS P P + Q++ +D Y++ VDKE F D GDI
Sbjct: 137 APIPASLMENSLGPFPQHVQQIQ-SDAAQNYTIFYSISGPGVDKEPFNLFYIEKDT-GDI 194
Query: 293 YVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQEN 352
+ T+ +DRE+ + + Y A G YPL + +K++D NDN P VT+F V EN
Sbjct: 195 FCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAPYFEHRVTIFTVPEN 254
Query: 353 ERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKK 412
R G S+G +TA D DE +T ++ L Y+I++Q P P F I G++ L +
Sbjct: 255 CRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIPDHPKH--FSIHPDTGVITTTTPFLDR 312
Query: 413 QDTPQYNLTIEVSDKDFKTLCF-----VQINVIDINDQIPIFEKSDYGNLTLAEDTNIGS 467
+ Y L +EV D + + I++ D ND P F ++ Y +T E+ I
Sbjct: 313 EKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSY--VTEVEENRIDV 370
Query: 468 TILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVS 527
IL ++ D D P T SK +Y I++G+ G + TDP+TN G + + KPL++E
Sbjct: 371 EILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLNYEVN--R 428
Query: 528 NIVFKAENPEPLVFGVKYNASSFAKFTLIVT----DVNEAPQFSQHVFQAKVSEDVAIGT 583
++ + F ++ + T VT D +E P+ V + + G
Sbjct: 429 QVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDGFPAGQ 488
Query: 584 KVGNVTAKDPE---GLDISYSLRGDTRGWLKIDHVTGEIFSVAPLDREA----GSPYRVQ 636
++ A DPE G + Y GD W +I+ TG++ ++ LDRE+ + Y +
Sbjct: 489 ELLGYKALDPEISSGEGLRYQKLGDEDNWFEINQHTGDLRTLKVLDRESKFVKNNQYNIS 548
Query: 637 VVATEVGGSSLSSVSEFHLILMDVNDNPPRLAKDYTGLFFCHPLSAPGSLIFEATDDDQH 696
VVA + G S + H L D ND+ P++ K+ T C + + + D D
Sbjct: 549 VVAVDAVGRSCTGTLVVH--LDDYNDHAPQIDKEVT---ICQ--NNEDFAVLKPVDPDGP 601
Query: 697 LFRGPHFTFSLGSGSLQNDWEVSKINGTHARLSTRHTEFEEREYVVLIRINDGGRPPLEG 756
GP F F L + + +N W + + +G A L R + Y V I+I D R L
Sbjct: 602 -ENGPPFQFFLDNSASKN-WNIEEKDGKTAILRQRQ-NLDYNYYSVPIQIKD--RHGLVA 656
Query: 757 IVSLPVTFCSCVEGSCFRPAGHQTGIPTVGMAVGILLTTLLVIGIILAVVFI 808
L V C C S R T + +G +V+G +L + +
Sbjct: 657 THMLTVRVCDCSTPSECRMKDKSTRDVRPNVILGRWAILAMVLGSVLLLCIL 708
Score = 109 bits (272), Expect = 1e-23
Identities = 118/448 (26%), Positives = 198/448 (44%), Gaps = 52/448 (11%)
Query: 65 ETDNIFVIERE-GLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNR 123
E N+F IE++ G ++ R++DRE L A A+G E P+P+ IK++D NDN
Sbjct: 180 EPFNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNA 239
Query: 124 PTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQIN 183
P F +V +N R G V ATDLD+P T + +L Y+I+ Q+P ++ +F I+
Sbjct: 240 PYFEHRVTIFTVPENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIP--DHPKHFSIH 297
Query: 184 NKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTEN-----I 238
TG I+ T + L+ K +Y L++ V+DMGGQ F+ T + EN
Sbjct: 298 PDTGVITTT---TPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSF 354
Query: 239 WKAPKPVEMVENSTDPHPIKITQVRWNDPG--------AQYSLVDKEKLPRFPFSID--- 287
+ E+ EN D ++I +++ D A Y ++ + F S D
Sbjct: 355 TETSYVTEVEENRID---VEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNT 411
Query: 288 QEGDIYVTQPLDREEKDAYVFY--AVAKDEYGK------PLSYPLEIHVKVKDINDNPPT 339
EG + V +PL+ E + + + ++ K P + VK+ D +D P
Sbjct: 412 NEGVLCVVKPLNYEVNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIID-SDEGPE 470
Query: 340 CPSPVTVFEVQENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTY 399
C PV V + Q+ G + L D E ++ L Y+ + D F I +
Sbjct: 471 CHPPVKVIQSQDGFPAGQEL--LGYKALDPEISSGEGLRYQKLGDE-----DNWFEINQH 523
Query: 400 AGMLQLAK---QSLKKQDTPQYNLTIEVSDKDFKTLC-FVQINVIDINDQIPIFEKSDYG 455
G L+ K + K QYN+++ D ++ + +++ D ND P +K
Sbjct: 524 TGDLRTLKVLDRESKFVKNNQYNISVVAVDAVGRSCTGTLVVHLDDYNDHAPQIDK---- 579
Query: 456 NLTLAEDTNIGSTILTIQATDADEPFTG 483
+T+ ++ ++ D D P G
Sbjct: 580 EVTICQN---NEDFAVLKPVDPDGPENG 604
>gi|13435361 desmocollin 1 isoform Dsc1a preproprotein [Homo
sapiens]
Length = 894
Score = 203 bits (516), Expect = 6e-52
Identities = 170/592 (28%), Positives = 268/592 (45%), Gaps = 44/592 (7%)
Query: 241 APKPVEMVENSTDPHPIKITQVRWNDPGAQYSL--------VDKEKLPRFPFSIDQEGDI 292
AP P ++ENS P P + Q++ +D Y++ VDKE F D GDI
Sbjct: 137 APIPASLMENSLGPFPQHVQQIQ-SDAAQNYTIFYSISGPGVDKEPFNLFYIEKDT-GDI 194
Query: 293 YVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQEN 352
+ T+ +DRE+ + + Y A G YPL + +K++D NDN P VT+F V EN
Sbjct: 195 FCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAPYFEHRVTIFTVPEN 254
Query: 353 ERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKK 412
R G S+G +TA D DE +T ++ L Y+I++Q P P F I G++ L +
Sbjct: 255 CRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIPDHPKH--FSIHPDTGVITTTTPFLDR 312
Query: 413 QDTPQYNLTIEVSDKDFKTLCF-----VQINVIDINDQIPIFEKSDYGNLTLAEDTNIGS 467
+ Y L +EV D + + I++ D ND P F ++ Y +T E+ I
Sbjct: 313 EKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSY--VTEVEENRIDV 370
Query: 468 TILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVS 527
IL ++ D D P T SK +Y I++G+ G + TDP+TN G + + KPL++E
Sbjct: 371 EILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLNYEVN--R 428
Query: 528 NIVFKAENPEPLVFGVKYNASSFAKFTLIVT----DVNEAPQFSQHVFQAKVSEDVAIGT 583
++ + F ++ + T VT D +E P+ V + + G
Sbjct: 429 QVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDGFPAGQ 488
Query: 584 KVGNVTAKDPE---GLDISYSLRGDTRGWLKIDHVTGEIFSVAPLDREA----GSPYRVQ 636
++ A DPE G + Y GD W +I+ TG++ ++ LDRE+ + Y +
Sbjct: 489 ELLGYKALDPEISSGEGLRYQKLGDEDNWFEINQHTGDLRTLKVLDRESKFVKNNQYNIS 548
Query: 637 VVATEVGGSSLSSVSEFHLILMDVNDNPPRLAKDYTGLFFCHPLSAPGSLIFEATDDDQH 696
VVA + G S + H L D ND+ P++ K+ T C + + + D D
Sbjct: 549 VVAVDAVGRSCTGTLVVH--LDDYNDHAPQIDKEVT---ICQ--NNEDFAVLKPVDPDGP 601
Query: 697 LFRGPHFTFSLGSGSLQNDWEVSKINGTHARLSTRHTEFEEREYVVLIRINDGGRPPLEG 756
GP F F L + + +N W + + +G A L R + Y V I+I D R L
Sbjct: 602 -ENGPPFQFFLDNSASKN-WNIEEKDGKTAILRQRQ-NLDYNYYSVPIQIKD--RHGLVA 656
Query: 757 IVSLPVTFCSCVEGSCFRPAGHQTGIPTVGMAVGILLTTLLVIGIILAVVFI 808
L V C C S R T + +G +V+G +L + +
Sbjct: 657 THMLTVRVCDCSTPSECRMKDKSTRDVRPNVILGRWAILAMVLGSVLLLCIL 708
Score = 109 bits (272), Expect = 1e-23
Identities = 118/448 (26%), Positives = 198/448 (44%), Gaps = 52/448 (11%)
Query: 65 ETDNIFVIERE-GLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNR 123
E N+F IE++ G ++ R++DRE L A A+G E P+P+ IK++D NDN
Sbjct: 180 EPFNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNA 239
Query: 124 PTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQIN 183
P F +V +N R G V ATDLD+P T + +L Y+I+ Q+P ++ +F I+
Sbjct: 240 PYFEHRVTIFTVPENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIP--DHPKHFSIH 297
Query: 184 NKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTEN-----I 238
TG I+ T + L+ K +Y L++ V+DMGGQ F+ T + EN
Sbjct: 298 PDTGVITTT---TPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSF 354
Query: 239 WKAPKPVEMVENSTDPHPIKITQVRWNDPG--------AQYSLVDKEKLPRFPFSID--- 287
+ E+ EN D ++I +++ D A Y ++ + F S D
Sbjct: 355 TETSYVTEVEENRID---VEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNT 411
Query: 288 QEGDIYVTQPLDREEKDAYVFY--AVAKDEYGK------PLSYPLEIHVKVKDINDNPPT 339
EG + V +PL+ E + + + ++ K P + VK+ D +D P
Sbjct: 412 NEGVLCVVKPLNYEVNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIID-SDEGPE 470
Query: 340 CPSPVTVFEVQENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTY 399
C PV V + Q+ G + L D E ++ L Y+ + D F I +
Sbjct: 471 CHPPVKVIQSQDGFPAGQEL--LGYKALDPEISSGEGLRYQKLGDE-----DNWFEINQH 523
Query: 400 AGMLQLAK---QSLKKQDTPQYNLTIEVSDKDFKTLC-FVQINVIDINDQIPIFEKSDYG 455
G L+ K + K QYN+++ D ++ + +++ D ND P +K
Sbjct: 524 TGDLRTLKVLDRESKFVKNNQYNISVVAVDAVGRSCTGTLVVHLDDYNDHAPQIDK---- 579
Query: 456 NLTLAEDTNIGSTILTIQATDADEPFTG 483
+T+ ++ ++ D D P G
Sbjct: 580 EVTICQN---NEDFAVLKPVDPDGPENG 604
>gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens]
Length = 801
Score = 202 bits (513), Expect = 1e-51
Identities = 162/541 (29%), Positives = 249/541 (46%), Gaps = 32/541 (5%)
Query: 287 DQEGDIYVTQPLDREEKDAYVFYAVAKDEY-GKPLSYPLEIHVKVKDINDNPPTCPSPVT 345
D GDI+ Q LDREE+ Y A A D G+P+ E +K++DINDN P
Sbjct: 111 DTTGDIHAIQRLDREERAQYTLRAQALDRRTGRPMEPESEFIIKIQDINDNEPKFLDGPY 170
Query: 346 VFEVQENERLGNSIGTLTAHDRDEENTANSF-LNYRIVEQTPKLPMDGLFLIQTYAGMLQ 404
V V E +G S+ +TA D D+ NS + Y I++ P F + + G+++
Sbjct: 171 VATVPEMSPVGTSVIQVTATDADDPTYGNSARVVYSILQGQP------YFSVDSKTGVIR 224
Query: 405 LAKQSLKKQDTPQYNLTIEVSDKDFKT-----LCFVQINVIDINDQIPIFEKSDYGNLTL 459
A ++ ++ Y + I+ D + V I + D+ND P F + Y +++
Sbjct: 225 TALMNMDREAKEYYEVIIQAKDMGGQLGGLAGTTTVNITLSDVNDNPPRFPQKHY-QMSV 283
Query: 460 AEDTNIGSTILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPL 519
E I ST+ + A D DE K Y I+ GD + TDP+ G + +KKPL
Sbjct: 284 LESAPISSTVGRVFAKDLDEGINAEMK--YTIVDGDGADAFDISTDPNFQVGIITVKKPL 341
Query: 520 DFETAAVSNIVFKAENPEPLVFGVKYNASSFAKFTLI---VTDVNEAPQFSQHVFQAKVS 576
FE+ + K E P + N F T + V DV+E P F + +V
Sbjct: 342 SFESK--KSYTLKVEGANPHLEMRFLNLGPFQDTTTVHISVEDVDEPPVFEPGFYFVEVP 399
Query: 577 EDVAIGTKVGNVTAKDPEGLD--ISYSL--RGDTRGWLKIDHVTGEIFSVAPLDREAGSP 632
EDVAIGT + ++AKDP+ + I YS+ D + +D TG + + PLDRE S
Sbjct: 400 EDVAIGTTIQIISAKDPDVTNNSIRYSIDRSSDPGRFFYVDITTGALMTARPLDREEFSW 459
Query: 633 YRVQVVATEVGGSSLSSVSEFHLILMDVNDNPPRLAKDYTGLFFCHPLSAPGSLIFEATD 692
+ + V+A E+ S + ++DVNDN P + Y F C A G LI +
Sbjct: 460 HNITVLAMEMNNPSQVGSVPVTIKVLDVNDNAPEFPRFYEA-FVCENAKA-GQLIQTVSA 517
Query: 693 DDQHLFR-GPHFTFSLGSGSLQN-DWEVSKINGTHARLSTRHTEFEEREYVVL---IRIN 747
DQ R G HF +SL + N ++ + AR+ TR + F ++E V I I
Sbjct: 518 VDQDDPRNGQHFYYSLAPEAANNPNFTIRDNQDNTARILTRRSGFRQQEQSVFHLPILIA 577
Query: 748 DGGRPPLEGIVSLPVTFCSCVEGSCFRPAGHQTGIPTVGMAVGILLTTLLVIGIILAVVF 807
D G+P L +L + CSC + + + V ++ G L+ L I ++L +V
Sbjct: 578 DSGQPVLSSTGTLTIQVCSCDDDGHVMSCSPEAYMLPVSLSRGALIAILACIFVLLVLVL 637
Query: 808 I 808
+
Sbjct: 638 L 638
Score = 132 bits (331), Expect = 2e-30
Identities = 126/451 (27%), Positives = 198/451 (43%), Gaps = 54/451 (11%)
Query: 58 VTFELTGETDNIFVIEREGLLYYNRALDRETRSTHNLQVAALDAN-GIIVEGPVPITIKV 116
+ F + T +I I+R LDRE R+ + L+ ALD G +E IK+
Sbjct: 105 IVFTIDDTTGDIHAIQR---------LDREERAQYTLRAQALDRRTGRPMEPESEFIIKI 155
Query: 117 KDINDNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPN-GQLYYQIVIQLPMIN 175
+DINDN P FL Y +V + S G + V ATD DDP N ++ Y I+ P
Sbjct: 156 QDINDNEPKFLDGPYVATVPEMSPVGTSVIQVTATDADDPTYGNSARVVYSILQGQP--- 212
Query: 176 NVMYFQINNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDII-- 233
YF +++KTG I R ++ Y ++I KDMGGQ + TT+V+I
Sbjct: 213 ---YFSVDSKTGVI---RTALMNMDREAKEYYEVIIQAKDMGGQL-GGLAGTTTVNITLS 265
Query: 234 -VTENIWKAP-KPVEMVENSTDPHPIKITQVRWND------PGAQYSLVDKEKLPRFPFS 285
V +N + P K +M + P + +V D +Y++VD + F S
Sbjct: 266 DVNDNPPRFPQKHYQMSVLESAPISSTVGRVFAKDLDEGINAEMKYTIVDGDGADAFDIS 325
Query: 286 ID---QEGDIYVTQPLDREEKDAYVFYAVAKDEYGK-------PLSYPLEIHVKVKDIND 335
D Q G I V +PL E K +Y + + + P +H+ V+D+ D
Sbjct: 326 TDPNFQVGIITVKKPLSFESKKSYTLKVEGANPHLEMRFLNLGPFQDTTTVHISVEDV-D 384
Query: 336 NPPTCPSPVTVFEVQENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFL 395
PP EV E+ +G +I ++A D D N+ + Y I + F
Sbjct: 385 EPPVFEPGFYFVEVPEDVAIGTTIQIISAKDPD---VTNNSIRYSIDRSSDP---GRFFY 438
Query: 396 IQTYAGMLQLAKQSLKKQDTPQYNLTI---EVSDKDFKTLCFVQINVIDINDQIPIFEKS 452
+ G L A+ L +++ +N+T+ E+++ V I V+D+ND P F +
Sbjct: 439 VDITTGALMTAR-PLDREEFSWHNITVLAMEMNNPSQVGSVPVTIKVLDVNDNAPEFPR- 496
Query: 453 DYGNLTLAEDTNIGSTILTIQATDADEPFTG 483
+ + E+ G I T+ A D D+P G
Sbjct: 497 -FYEAFVCENAKAGQLIQTVSAVDQDDPRNG 526
Score = 71.6 bits (174), Expect = 3e-12
Identities = 54/157 (34%), Positives = 76/157 (48%), Gaps = 6/157 (3%)
Query: 76 GLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNRPTFLQSKYEGSV 135
G L R LDRE S HN+ V A++ N G VP+TIKV D+NDN P F + YE V
Sbjct: 444 GALMTARPLDREEFSWHNITVLAMEMNNPSQVGSVPVTIKVLDVNDNAPEFPRF-YEAFV 502
Query: 136 RQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQINNKTGAISLTREG 195
+N++ G+ V+A D DDP NGQ +Y + N + N A LTR
Sbjct: 503 CENAKAGQLIQTVSAVDQDDPR--NGQHFYYSLAPEAANNPNFTIRDNQDNTARILTRRS 560
Query: 196 SQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDI 232
+ ++L I + D GQ S + T ++ +
Sbjct: 561 G--FRQQEQSVFHLPILIAD-SGQPVLSSTGTLTIQV 594
Score = 43.1 bits (100), Expect = 0.001
Identities = 46/159 (28%), Positives = 74/159 (46%), Gaps = 10/159 (6%)
Query: 598 ISYSLRGDTRGWL-KIDHVTGEIFSVAPLDREAGSPYRVQVVATE-VGGSSLSSVSEFHL 655
I Y L G+ G + ID TG+I ++ LDRE + Y ++ A + G + SEF +
Sbjct: 94 IKYILSGEGAGIVFTIDDTTGDIHAIQRLDREERAQYTLRAQALDRRTGRPMEPESEFII 153
Query: 656 ILMDVNDNPPRLAKDYTGLFFCHPLSAPGSLIFE--ATD-DDQHLFRGPHFTFSLGSGSL 712
+ D+NDN P+ D + +S G+ + + ATD DD +S+ G
Sbjct: 154 KIQDINDNEPKFL-DGPYVATVPEMSPVGTSVIQVTATDADDPTYGNSARVVYSILQG-- 210
Query: 713 QNDWEVSKINGTHARLSTRHTEFEEREYV-VLIRINDGG 750
Q + V G R + + + E +EY V+I+ D G
Sbjct: 211 QPYFSVDSKTGV-IRTALMNMDREAKEYYEVIIQAKDMG 248
>gi|16306539 cadherin 8, type 2 preproprotein [Homo sapiens]
Length = 799
Score = 202 bits (513), Expect = 1e-51
Identities = 166/595 (27%), Positives = 276/595 (46%), Gaps = 39/595 (6%)
Query: 247 MVENSTDPHPIKITQVRWN-DPGAQ---YSLVDKEKLPRFPFSIDQEGDIYVTQPLDREE 302
++E + P PI + ++ + DPG++ Y L F + D GDI+ + LDREE
Sbjct: 70 VLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQIN-DVTGDIHAIKRLDREE 128
Query: 303 KDAYVFYAVAKD-EYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERLGNSIGT 361
K Y A A D E KPL P E +KV+DINDN P + V E LG S+
Sbjct: 129 KAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTN 188
Query: 362 LTAHDRDEENTANSF-LNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTPQYNL 420
+TA D D+ NS L Y I+E P F I+ +++ A ++ ++ +Y +
Sbjct: 189 VTATDADDPVYGNSAKLVYSILEGQP------YFSIEPETAIIKTALPNMDREAKEEYLV 242
Query: 421 TIEVSDKD-----FKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQAT 475
I+ D + + + D+ND P F +S Y + ++ ED +G+ I ++A
Sbjct: 243 VIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLY-HFSVPEDVVLGTAIGRVKAN 301
Query: 476 DADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVSNIVFKAEN 535
D D S Y II GD + +D G + ++KPLDFET + +A N
Sbjct: 302 DQDIGENAQSS--YDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAAN 359
Query: 536 P--EPLVFGVKYNASSFAKFTLIVTDVNEAPQFSQHVFQAKVSEDVAIGTKVGNVTAKDP 593
+P G + A ++V D +E P FS + +V E+ A+ + +G VTA+DP
Sbjct: 360 VHIDPRFSG-RGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARDP 418
Query: 594 E----GLDISYSLRGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSLSS 649
+ + S D I+ G+I PLDRE + + ++ATE+ S S
Sbjct: 419 DITSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQIS 478
Query: 650 VSEFHLILMDVNDNPPRLAKDYTGLFFCHPLSAPGSLI--FEATDDDQHLFRGPHFTFSL 707
+ ++DVNDN P A +Y F C PG +I A D D G +F +SL
Sbjct: 479 RVPVAIKVLDVNDNAPEFASEYEA-FLCEN-GKPGQVIQTVSAMDKDDPK-NGHYFLYSL 535
Query: 708 GSGSLQN-DWEVSKINGTHARLSTRHTEFEERE---YVVLIRINDGGRPPLEGIVSLPVT 763
+ N ++ + K + +H F ++ Y++ I I+D G PPL +L +
Sbjct: 536 LPEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIR 595
Query: 764 FCSCVEGSCFRPAGHQTGIPTVGMAVGILLTTL--LVIGIILAVVFIRIKKDKGK 816
C C + + + +G+++G L+ L +++ +++ V+F+ +++ K +
Sbjct: 596 VCGCSNDGVVQSCNVEAYVLPIGLSMGALIAILACIILLLVIVVLFVTLRRHKNE 650
Score = 138 bits (348), Expect = 2e-32
Identities = 142/490 (28%), Positives = 219/490 (44%), Gaps = 66/490 (13%)
Query: 26 KFSGPLKPMTFSIYEGQEPS--QIIFQFKANPPAVTFELTGETDNIFVIEREGLLYYNRA 83
+FSGP + ++ +P +I + + F++ T +I I+R
Sbjct: 73 EFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTGDIHAIKR--------- 123
Query: 84 LDRETRSTHNLQVAALD-ANGIIVEGPVPITIKVKDINDNRPTFLQSKYEGSVRQNSRPG 142
LDRE ++ + L A+D +E P IKV+DINDN P FL Y +V + S G
Sbjct: 124 LDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILG 183
Query: 143 KPFLYVNATDLDDPATPN-GQLYYQIVIQLPMINNVMYFQINNKTGAI-----SLTREGS 196
V ATD DDP N +L Y I+ P YF I +T I ++ RE
Sbjct: 184 TSVTNVTATDADDPVYGNSAKLVYSILEGQP------YFSIEPETAIIKTALPNMDREAK 237
Query: 197 QELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTENIWKAPKPVEMVENSTDPHP 256
+E Y +VI KDMGG S S TT++ + +T+ PK + + + + P
Sbjct: 238 EE--------YLVVIQAKDMGGHS-GGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPED 288
Query: 257 I----KITQVRWNDPG------AQYSLVDKEKLPRFPFSID---QEGDIYVTQPLDREEK 303
+ I +V+ ND + Y ++D + F + D Q+G I + +PLD E K
Sbjct: 289 VVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETK 348
Query: 304 DAYVFYAVAKDEY------GK-PLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERLG 356
+Y A + + G+ P + + V+D D PP SP + EV EN L
Sbjct: 349 KSYTLKVEAANVHIDPRFSGRGPFKDTATVKIVVEDA-DEPPVFSSPTYLLEVHENAALN 407
Query: 357 NSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTP 416
+ IG +TA D D +S + + I T ++ F I G + LA L ++ +
Sbjct: 408 SVIGQVTARDPD---ITSSPIRFSIDRHT---DLERQFNINADDGKITLA-TPLDRELSV 460
Query: 417 QYNLTI---EVSDKDFKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQ 473
+N+TI E+ + + V I V+D+ND P F S+Y L E+ G I T+
Sbjct: 461 WHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPEF-ASEY-EAFLCENGKPGQVIQTVS 518
Query: 474 ATDADEPFTG 483
A D D+P G
Sbjct: 519 AMDKDDPKNG 528
Score = 72.0 bits (175), Expect = 2e-12
Identities = 61/210 (29%), Positives = 92/210 (43%), Gaps = 15/210 (7%)
Query: 27 FSGPLKPMTFSIYEGQEPSQIIFQFKANPPAVT-----FELTGETD---NIFVIEREGLL 78
FS P ++E + +I Q A P +T F + TD + +G +
Sbjct: 391 FSSPT--YLLEVHENAALNSVIGQVTARDPDITSSPIRFSIDRHTDLERQFNINADDGKI 448
Query: 79 YYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNRPTFLQSKYEGSVRQN 138
LDRE HN+ + A + VP+ IKV D+NDN P F S+YE + +N
Sbjct: 449 TLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPEFA-SEYEAFLCEN 507
Query: 139 SRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQINNKTGAISLTREGSQE 198
+PG+ V+A D DDP NG Y+ + M+NN + N+ ++S+ +
Sbjct: 508 GKPGQVIQTVSAMDKDDP--KNGH-YFLYSLLPEMVNNPNFTIKKNEDNSLSILAK-HNG 563
Query: 199 LNPAKNPSYNLVISVKDMGGQSENSFSDTT 228
N K Y L I + D G +S S T
Sbjct: 564 FNRQKQEVYLLPIIISDSGNPPLSSTSTLT 593
>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
Length = 4557
Score = 196 bits (499), Expect = 6e-50
Identities = 204/753 (27%), Positives = 345/753 (45%), Gaps = 60/753 (7%)
Query: 69 IFVIERE-GLLYYNRALDRETRSTHNLQVAA-LDANGIIVEGPVPITIKVKDINDNRPTF 126
IFVIE+E G + ++ LDRET + +VAA + + + + V + IKV D+NDN+P F
Sbjct: 2755 IFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVF 2814
Query: 127 LQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQINNKT 186
S Y+ + + G V A D+D A NGQ+ Y + + F I++ T
Sbjct: 2815 ETSSYDTIIMEGMPVGTKLTQVRAIDMDWGA--NGQVTYSLHSDSQPEKVMEAFNIDSNT 2872
Query: 187 GAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTENIWKAPKPVE 246
G IS ++ L+ +P++ + D+G S S T V + VT+ AP +
Sbjct: 2873 GWISTLKD----LDHETDPTFTFSVVASDLG--EAFSLSSTALVSVRVTDINDNAPVFAQ 2926
Query: 247 MV-----ENSTDPHPIKITQVRWN----DPGAQYSLVDKEKLPRFPFS---IDQEGDIYV 294
V + S P + W+ D Q S PR F+ + E +YV
Sbjct: 2927 EVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYV 2986
Query: 295 TQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENER 354
+PLDREE+D Y A D G ++ + + V V D+NDN P C + E+
Sbjct: 2987 KRPLDREEQDIYFLNITATD--GLFVTQAM-VEVSVSDVNDNSPVCDQVAYTALLPEDIP 3043
Query: 355 LGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQD 414
I ++A D D + N ++ Y + + F + +G L+ L ++
Sbjct: 3044 SNKIILKVSAKDADIGS--NGYIRYSLYGSG-----NSEFFLDPESGELKTLAL-LDRER 3095
Query: 415 TPQYNLTIEVSDKDFKTLCFVQINVI--DINDQIPIFEKSDYGNLTLAEDTNIGSTILTI 472
P Y+L + +D + C I++I D+ND P+F SD+ N + E+T + + +
Sbjct: 3096 IPVYSLMAKATDGGGR-FCQSNIHLILEDVNDNPPVFS-SDHYNTCVYENTATKALLTRV 3153
Query: 473 QATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVSNIVFK 532
QA D D G ++ + + + + G +D+ ++G +I+++PLD E + NI +
Sbjct: 3154 QAVDPD---IGINRKVVYSLADSAGGVFSIDS----SSGIIILEQPLDREQQSSYNISVR 3206
Query: 533 AENPEPLVFGVKYNASSFAKFTLIVTDVNEAPQ-FSQHVFQAKVSEDVAIGTKVGNV--T 589
A + P + SS T+ V D+N+ P F + + V ED + GT+V V T
Sbjct: 3207 ATDQSP-----GQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFAT 3261
Query: 590 AKD-PEGLDISYSLR-GDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSL 647
+KD +I+Y +R G+ +G KI+ TG I LD E + + V A + G +L
Sbjct: 3262 SKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPAL 3321
Query: 648 SSVSEFHLILMDVNDNPPRLAKD-YTGLFFCHPLSAPGSLIFEATDDDQHLFRGPHFTFS 706
S+V+ ++ L DVNDNPP+ ++D Y+ + L ++ A D D H FS
Sbjct: 3322 SAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIH--FS 3379
Query: 707 LGSGSLQNDWEVSKINGTHARLSTRHTEFEEREYVVLIRINDGGRPPLEGIVSLPVTFCS 766
+ +G N++ V + G ++ + Y +L++ D G P + ++ +
Sbjct: 3380 IVNGDRDNEFTVDPVLGL-VKVKKKLDRERVSGYSLLVQAVDSGIPAMSSTATVNIDISD 3438
Query: 767 CVEGS-CFRPAGHQTGIPTVGMAVGILLTTLLV 798
+ S F PA + T + VG + L+V
Sbjct: 3439 VNDNSPVFTPANY-TAVIQENKPVGTSILQLVV 3470
Score = 183 bits (464), Expect = 7e-46
Identities = 198/747 (26%), Positives = 325/747 (43%), Gaps = 94/747 (12%)
Query: 34 MTFSIYEGQEPSQIIFQFKANPPAVTFELTGETDNIFVIEREGLLYYNRALDRETRSTHN 93
+T+S++ +P +++ F + G + + LD ET T
Sbjct: 2849 VTYSLHSDSQPEKVMEAFNID------------------SNTGWISTLKDLDHETDPTFT 2890
Query: 94 LQVAALD-ANGIIVEGPVPITIKVKDINDNRPTFLQSKYEGSVRQNSRPGKPFLYVNATD 152
V A D + ++++V DINDN P F Q Y G+V+++ PG+ ++ D
Sbjct: 2891 FSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWD 2950
Query: 153 LDDPATPNGQLYYQIVIQLPMINNVMYFQINNKTGAISLTREGSQELNPAKNPS------ 206
D + N Q+ Y I N G +L S+ K P
Sbjct: 2951 RDT-SDVNRQVSYHITG-------------GNPRGRFALGLVQSEWKVYVKRPLDREEQD 2996
Query: 207 -YNLVISVKD----MGGQSENSFSDTTSVDIIVTENIWKAPKPVEMVENSTDPHPIKITQ 261
Y L I+ D E S SD + + + A P ++ N I
Sbjct: 2997 IYFLNITATDGLFVTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKI----ILKVS 3052
Query: 262 VRWNDPGA----QYSLVDKEKLPRFPFSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEY 316
+ D G+ +YSL F +D E G++ LDRE Y A A D
Sbjct: 3053 AKDADIGSNGYIRYSLYGSGNSE---FFLDPESGELKTLALLDRERIPVYSLMAKATDGG 3109
Query: 317 GKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERLGNSIGTLTAHDRDEENTANSF 376
G+ IH+ ++D+NDNPP S V EN + + A D D N
Sbjct: 3110 GRFCQS--NIHLILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIG--INRK 3165
Query: 377 LNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTPQYNLTIEVSDKD----FKTL 432
+ Y + + G+F I + +G++ L +Q L ++ YN+++ +D+ +L
Sbjct: 3166 VVYSLADSA-----GGVFSIDSSSGIIIL-EQPLDREQQSSYNISVRATDQSPGQSLSSL 3219
Query: 433 CFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQATDADEPFTGSSKILYHII 492
V I V+DIND P+FE+ DY +T+ EDT+ G+ +L + AT D +++I Y I
Sbjct: 3220 TTVTITVLDINDNPPVFERRDY-LVTVPEDTSPGTQVLAVFATSKD--IGTNAEITYLIR 3276
Query: 493 KGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVSNIVFKAENPEPLVFGVKYNASSFAK 552
G+ +G+ ++ TG + + + LD+E +V +A++ G S+ A
Sbjct: 3277 SGNEQGKFKINP----KTGGISVSEVLDYELCKRFYLVVEAKD------GGTPALSAVAT 3326
Query: 553 FTLIVTDVNE-APQFSQHVFQAKVSEDVAIGTKVGNVTAKD----PEGLDISYSL-RGDT 606
+ +TDVN+ P+FSQ V+ A +SED +G V + A+D P G I +S+ GD
Sbjct: 3327 VNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNG-QIHFSIVNGDR 3385
Query: 607 RGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSLSSVSEFHLILMDVNDNPPR 666
+D V G + LDRE S Y + V A + G ++SS + ++ + DVNDN P
Sbjct: 3386 DNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPAMSSTATVNIDISDVNDNSPV 3445
Query: 667 LAK-DYTGLFFCHPLSAPGSLIFEATDDDQHLFRGPHFTFSLGSGSLQNDWEVSKINGTH 725
+YT + + L TD D GP F+FS+ SG+ + ++ +
Sbjct: 3446 FTPANYTAVIQENKPVGTSILQLVVTDRDS-FHNGPPFSFSILSGNEEEEFVLDPHGILR 3504
Query: 726 ARLSTRHTEFEEREYVVLIRINDGGRP 752
+ + +HT E EYV+ ++ D G+P
Sbjct: 3505 SAVVFQHT--ESLEYVLCVQAKDSGKP 3529
Score = 157 bits (396), Expect = 5e-38
Identities = 177/689 (25%), Positives = 297/689 (43%), Gaps = 76/689 (11%)
Query: 84 LDRETRSTHNLQVAALDANG--IIVEGPVPITIKVKDINDNRPTFLQSKYEGSVRQNSRP 141
LD ET + + V D+ + E PV + I+V D+NDN P F Q+ +E + +
Sbjct: 1839 LDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYV 1898
Query: 142 GKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQINNKTGAISLTREGSQELNP 201
G L V+ATD D P +L Y + M ++ +F I++ +G +++ N
Sbjct: 1899 GVEVLKVSATDPDSEVPP--ELTYSL-----MEGSLDHFLIDSNSGVLTIKN------NN 1945
Query: 202 AKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTE------NIWKAPKPVEMVENSTDPH 255
Y L++ V S+ F T+ V I+V E + ++ + EN+T+
Sbjct: 1946 LSKDHYMLIVKV------SDGKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNIT 1999
Query: 256 PIKITQV---RWNDPGAQYSLVDKEKLPRFPFSIDQEGDIYVTQ--PLDREEKDAYVFYA 310
+ I R N+P +YS+++ P F I + T P DREE++ Y
Sbjct: 2000 KVAIVNAVGNRLNEP-LKYSILN----PGNKFKIKSTSGVIQTTGVPFDREEQELYELVV 2054
Query: 311 VAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERLGNSIGTLTAHDRDEE 370
A E + + V ++DINDN P VQ + G I +TA D+D+
Sbjct: 2055 EASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDK- 2113
Query: 371 NTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTPQYNLTIEVSDKDFK 430
N + Y + + G F I +G + L + +Y +TI D
Sbjct: 2114 -GPNGEVTYVLQDDY------GHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKP 2166
Query: 431 TL-CFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQATDADEPFTGSSKILY 489
+L V++ + +N +P+F+K Y ++ ED + + IL+I AT + I+Y
Sbjct: 2167 SLSTSVELPITIVNKAMPVFDKPFY-TASVNEDIRMNTPILSINATSPE-----GQGIIY 2220
Query: 490 HIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVSNIVFKAENPEPLVFGVKYNASS 549
II GD + +D D TG + + PLD+E + + +A + A +
Sbjct: 2221 IIIDGDPFKQFNIDFD----TGVLKVVSPLDYEVTSAYKLTIRASD-------ALTGARA 2269
Query: 550 FAKFTLIVTDVNEAPQ-FSQHVFQAKVSEDVAIGTKVGNVTAKDPEGLD---ISYSLRGD 605
L+V DVN+ P F Q + +SE IGT V V + D + + + Y + D
Sbjct: 2270 EVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQD 2329
Query: 606 T---RGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSLSSVSEFHLILMDVND 662
T + ID +G I + LD E ++V + + G SLSS H+ + DVND
Sbjct: 2330 TYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVND 2389
Query: 663 NPPRLAKDYTGLFFCHPLSAPGSLI--FEATDDDQHLFRGPHFTFSLGSGSLQNDWEVSK 720
NPP + + L+ G + +A+D D F +S+ SG+ + + +
Sbjct: 2390 NPP-VFNQLIYESYVSELAPRGHFVTCVQASDADSSDF--DRLEYSILSGNDRTSFLMDS 2446
Query: 721 INGTHARLSTRHTEFEEREYVVLIRINDG 749
+G LS + E Y + + ++DG
Sbjct: 2447 KSGV-ITLSNHRKQRMEPLYSLNVSVSDG 2474
Score = 150 bits (380), Expect = 4e-36
Identities = 176/665 (26%), Positives = 284/665 (42%), Gaps = 68/665 (10%)
Query: 58 VTFELTGETDNIFVIEREGLLYYNRALDRETRSTHNLQVAALDA--NGIIVEGPVPITIK 115
VT+ + +T + G++Y LDRE+++ ++L++ A D +G + V + +
Sbjct: 866 VTYSVLTDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVF 925
Query: 116 VKDINDNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMIN 175
+ D+ND P F+ S Y V ++ G ++ D D GQ+ Y +V
Sbjct: 926 LDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPD--LGLGGQVRYSLVNDYNG-- 981
Query: 176 NVMYFQINNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDII-V 234
F+I+ +GAI L S+EL+ K YNL + KD G S V+++ V
Sbjct: 982 ---RFEIDKASGAIRL----SKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDV 1034
Query: 235 TENIWKAPKPVEMV-----ENSTDPHPIKITQVRWNDPGA----QYSLVDKEKLPRFPFS 285
EN+ P V ENS + R D G QYS+ D L RF
Sbjct: 1035 NENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSID 1094
Query: 286 IDQEGDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVT 345
D+ G I LDRE +Y A D PL +E++++V+D+NDN P P+
Sbjct: 1095 -DESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIY 1153
Query: 346 VFEVQENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQL 405
V EN S+ + A D D +++N L YRI P+ F I G++
Sbjct: 1154 YPVVMENSPKDVSVIQIQAEDPD--SSSNEKLTYRITSGNPQ----NFFAINIKTGLITT 1207
Query: 406 AKQSLKKQDTPQYNLTIEVSD---KDFKTLCFVQINVIDINDQIPIFEKSDYG-NLTLAE 461
+ L ++ ++ L + V+D ++ +V + V+D ND P F + Y L +
Sbjct: 1208 TSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERD 1267
Query: 462 DTNIGSTILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDF 521
G I A D DE +++I Y I+ G+ +G+ +D TG V +K F
Sbjct: 1268 RKKRGEPIYRAFAFDRDE--GPNAEISYSIVDGNDDGKFFID----PKTGMVSSRK--QF 1319
Query: 522 ETAAVSNIVFKA-ENPEPLVFGVKYNASSFAKFTLIVTDVNEAP------QFSQHVFQAK 574
+ + KA +N P SS A+ L + + + P F + +
Sbjct: 1320 TAGSYDILTIKAVDNGRP-------QKSSTAR--LHIEWIKKPPPSPIPLTFDEPFYNFT 1370
Query: 575 VSEDVAIGTKVGNVT---AKDPEGLDISYSLRGDTRGWLKIDHVTGEIFSVAPLDREAGS 631
V E + VG V+ A P DI + G+ + G I PLD E S
Sbjct: 1371 VMESDRVTEIVGVVSVQPANTPLWFDI---VGGNFDSAFDAEKGVGTIVIAKPLDAEQRS 1427
Query: 632 PYRVQVVATEVGGSSLSSVSEFHLILMDVNDNPPRLAK-DYTGLFFCHPLSAPGSLIFEA 690
Y + V T+ G+++ +V++ + ++D NDN P ++ +Y L L EA
Sbjct: 1428 IYNMSVEVTD--GTNV-AVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEA 1484
Query: 691 TDDDQ 695
TD D+
Sbjct: 1485 TDRDE 1489
Score = 146 bits (369), Expect = 7e-35
Identities = 180/713 (25%), Positives = 302/713 (42%), Gaps = 94/713 (13%)
Query: 107 EGPVPITIKVKDINDNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQ 166
E V +TI++ ++NDN P F + +G + + G V+A D+D+ + Y+
Sbjct: 559 ESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELEL----VKYK 614
Query: 167 IVIQLPMINNVMYFQINNKTGAI----SLTREGSQELNPA--------KNPSYNLVISVK 214
I+ N + +F +N +G + SLT G + N A +N + + I++
Sbjct: 615 IISG----NELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINIS 670
Query: 215 DMGGQ-SENSFS-DTTSVDIIVTENIW---KAPKPVEMVENSTDPHPIKITQVRWNDPGA 269
+ G+ S SFS T V + E + KA + + + D + I Q + D
Sbjct: 671 VLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSIN-RQGPYFDKSF 729
Query: 270 QYSLVDKEKLPRFP------------------------------FSIDQE-GDIYVTQPL 298
+ KE LP F+ID E G + V P+
Sbjct: 730 PSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPM 789
Query: 299 DREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERLGNS 358
DRE D Y+ D S + + V+D NDN P + E+ +G
Sbjct: 790 DREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTE 849
Query: 359 IGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTPQY 418
I + A D+D + N + Y ++ T + F I + G++ +A Q L ++ Y
Sbjct: 850 IIQVEARDKDLGS--NGEVTYSVLTDTQQ------FAINSSTGIVYVADQ-LDRESKANY 900
Query: 419 NLTIEVSDK-----DFKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQ 473
+L IE DK ++ +++ + D+ND P F S Y ++ + ED +G+ I ++
Sbjct: 901 SLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSY-SVKVLEDLPVGTVIAWLE 959
Query: 474 ATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVSNIVFKA 533
D D G ++ Y ++ D GR +D +G + + K LD+E N+ +A
Sbjct: 960 THDPDLGLGG--QVRYSLVN-DYNGRFEIDKA----SGAIRLSKELDYEKQQFYNLTVRA 1012
Query: 534 ENPEPLVFGVKYNASSFAKFTLIVTDVNE---APQFSQHVFQAKVSEDVAIGTKVGNVTA 590
++ G + SS + + V DVNE P F V E+ IGT V VTA
Sbjct: 1013 KDK-----GRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTA 1067
Query: 591 KDPE-GLD--ISYSLR-GDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSS 646
+D + G D I YS+R G G ID +G I + LDRE Y + V AT+ G
Sbjct: 1068 RDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVP 1127
Query: 647 LSSVSEFHLILMDVNDNPPRLAKD-YTGLFFCHPLSAPGSLIFEATDDDQHLFRGPHFTF 705
L S E ++ + DVNDN P ++ Y + + + +A D D T+
Sbjct: 1128 LYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSS--SNEKLTY 1185
Query: 706 SLGSGSLQNDWEVSKINGTHARLSTRHTEFEEREYVVLIRINDGGRPPLEGIV 758
+ SG+ QN + ++ G S + ++ E+ + + + DGG P + +
Sbjct: 1186 RITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTI 1238
Score = 141 bits (355), Expect = 3e-33
Identities = 181/719 (25%), Positives = 317/719 (44%), Gaps = 116/719 (16%)
Query: 32 KPMTFSIYEGQEPSQI-IFQFKANPP------AVTFELT-GETDNIFVIE-REGLLYY-N 81
+P+ + + P + + Q +A P +T+ +T G N F I + GL+ +
Sbjct: 1150 EPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTS 1209
Query: 82 RALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNRPTFLQSKYEGSV--RQNS 139
R LDRE ++ H L+V D + + + ++V D NDN+P F + Y+ + R
Sbjct: 1210 RKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRK 1269
Query: 140 RPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQINNKTGAISLTRE---GS 196
+ G+P A D D+ PN ++ Y IV N+ F I+ KTG +S ++ GS
Sbjct: 1270 KRGEPIYRAFAFDRDEG--PNAEISYSIVDG----NDDGKFFIDPKTGMVSSRKQFTAGS 1323
Query: 197 QELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTENIWKAPKPVEMVENSTDPHP 256
++ L I D G ++S T + I E I K P P P
Sbjct: 1324 YDI---------LTIKAVDNGRPQKSS---TARLHI---EWIKKPP-----------PSP 1357
Query: 257 IKITQVRWNDPGAQYSLVDKEKLPR----------------------FPFSIDQE---GD 291
I +T +++P +++++ +++ F + D E G
Sbjct: 1358 IPLT---FDEPFYNFTVMESDRVTEIVGVVSVQPANTPLWFDIVGGNFDSAFDAEKGVGT 1414
Query: 292 IYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQE 351
I + +PLD E++ Y D ++ ++ +KV D NDN P P + E
Sbjct: 1415 IVIAKPLDAEQRSIYNMSVEVTDGTNVAVT---QVFIKVLDNNDNGPEFSQPNYDVTISE 1471
Query: 352 NERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLK 411
+ I + A DRDE++ L+Y + + M F I G+L A++ L
Sbjct: 1472 DVLPDTEILQIEATDRDEKHK----LSYTVHSSIDSISM-RKFRIDPSTGVLYTAER-LD 1525
Query: 412 KQDTPQYNLTIEVSDKDF---KTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGST 468
+ ++ L I V D++F + L V +NV D ND P F Y ++ E +GS
Sbjct: 1526 HEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLY-EASVFESAALGSA 1584
Query: 469 ILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAA--V 526
+L + A D D+ +++++Y I G++ ++ G + I K D T V
Sbjct: 1585 VLQVTALDKDK--GENAELIYTIEAGNTGNMFKIE----PVLGIITICKEPDMTTMGQFV 1638
Query: 527 SNIVFKAENPEPLVFGVKYNASSFAKFTLIVTDVNEAPQFSQHVFQAKVSEDVAIGTKVG 586
+I + P+ +A++ + ++ ++D N P+F +QA+V+E+V IGT V
Sbjct: 1639 LSIKVTDQGSPPM------SATAIVRISVTMSD-NSHPKFIHKDYQAEVNENVDIGTSVI 1691
Query: 587 NVTAKDPEGLDISYSLR-GDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGS 645
++A L Y ++ GD G I+ +G I + LD E S Y++ + AT + G
Sbjct: 1692 LISAISQSTL--IYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAG- 1748
Query: 646 SLSSVSEFHLILMDVNDNPP-RLAKDYTG-LFFCHPLSA------PGSLIFEATDDDQH 696
++S + ++ ++D NDN P L Y+G L P+++ L+ ATD D +
Sbjct: 1749 -MASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSN 1806
Score = 130 bits (326), Expect = 7e-30
Identities = 179/689 (25%), Positives = 293/689 (42%), Gaps = 74/689 (10%)
Query: 66 TDNIFVIEREGLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNRPT 125
TD + GL+ R LD E L+V ++D+ + V + I + D+NDN P
Sbjct: 2334 TDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPV 2393
Query: 126 FLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQINNK 185
F Q YE V + + G V A+D D ++ +L Y I+ N+ F +++K
Sbjct: 2394 FNQLIYESYVSELAPRGHFVTCVQASDAD--SSDFDRLEYSILSG----NDRTSFLMDSK 2447
Query: 186 TGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDI-IVTENIW----- 239
+G I+L+ Q + P Y+L +SV S+ F+ T V I ++ N++
Sbjct: 2448 SGVITLSNHRKQRMEPL----YSLNVSV------SDGLFTSTAQVHIRVLGANLYSPAFS 2497
Query: 240 KAPKPVEMVENSTDPHPIKITQVRWNDPG--AQYSLVDKEKLPRFPFSIDQEGDIYVTQP 297
++ E+ EN + + DPG Q S + F ID G + T+
Sbjct: 2498 QSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDRFLIDSNGQVITTER 2557
Query: 298 LDRE---EKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENER 354
LDRE E D +F A D G+ + V V D NDN P + V+ +
Sbjct: 2558 LDRENPLEGDVSIFVR-ALDGGGRTTF--CTVRVIVVDENDNAPQFMTVEYRASVRADVG 2614
Query: 355 LGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAK-QSLKKQ 413
G+ + + A D D+ ANS + Y + + D L + M+ LK
Sbjct: 2615 RGHLVTQVQAIDPDD--GANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNT 2672
Query: 414 DTPQYNLTIEVSDKDFKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQ 473
+ ++ +L V I+V+ +P F +S Y + T+AEDT IGST+ T++
Sbjct: 2673 VLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQY-SFTIAEDTAIGSTVDTLR 2731
Query: 474 ATDADEPFTGSSKILYHIIKGD-SEGRLGVDTDPHTNTGYVIIKKPLDFETAAVSNIVFK 532
S + + + G+ E G TG + + K LD ET+ + FK
Sbjct: 2732 -------ILPSQNVWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFH--FK 2782
Query: 533 AENPEPLVFGVKYNASSFAKFTLIVTDVNE-APQFSQHVFQAKVSEDVAIGTKVGNVTAK 591
PL K + + V D+N+ P F + + E + +GTK+ V A
Sbjct: 2783 VAATIPL---DKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAI 2839
Query: 592 DPE---GLDISYSLRGDTR-----GWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVG 643
D + ++YSL D++ ID TG I ++ LD E + VVA+++G
Sbjct: 2840 DMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLG 2899
Query: 644 GS-SLSSVSEFHLILMDVNDNPPRLAKD-YTGLFFCHPLSAPGSLIFEATDDDQ------ 695
+ SLSS + + + D+NDN P A++ Y G PG ++ + D+
Sbjct: 2900 EAFSLSSTALVSVRVTDINDNAPVFAQEVYRG--NVKESDPPGEVVAVLSTWDRDTSDVN 2957
Query: 696 -----HLFRG-PHFTFSLGSGSLQNDWEV 718
H+ G P F+L G +Q++W+V
Sbjct: 2958 RQVSYHITGGNPRGRFAL--GLVQSEWKV 2984
Score = 128 bits (321), Expect = 2e-29
Identities = 181/729 (24%), Positives = 294/729 (40%), Gaps = 107/729 (14%)
Query: 37 SIYEGQEPSQIIFQFKANPPAVTFELT---GETDNIFVIE-REGLLYYNRALDRETRSTH 92
SI E P ++ K +P + E GE F I R GL+ R L+ + +
Sbjct: 384 SISEFSPPGVVVAIVKLSPEPIDVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVY 443
Query: 93 NLQVAALDANGIIVEGPVPITIKVKDINDNRPTFLQSKYEGSVRQNSRPGKPFLYVNATD 152
L+V + + +TI ++D ND+ P F Q Y+ V ++ G L V+A+D
Sbjct: 444 KLEVTNKEG-----DLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASD 498
Query: 153 LDDPATPNGQLYYQIVIQLPMINNVMYFQINNKTGAISLTREGSQELNPAKNPSYNLVIS 212
D NG + Y I N++ F IN TG IS T E E +P Y ++
Sbjct: 499 KD--KGENGYITYSIASL-----NLLPFVINQFTGVISTTEELDFESSP---EIYRFIVR 548
Query: 213 VKDMGGQSENSFSDTTSVDIIVTENIWKAPKPVEMVENSTDPHPIKITQVRWNDPGAQYS 272
D W +P E N T I+I V ND +
Sbjct: 549 ASD-----------------------WGSPYRHESEVNVT----IRIGNV--NDNSPLFE 579
Query: 273 LVDKEKLPRFPFSIDQEGDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKD 332
V + + + F + G I +D +E + + ++ +E G P +++K
Sbjct: 580 KVACQGVISYDFPVG--GHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKK 637
Query: 333 INDNPPTCPSPVTVFEVQENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDG 392
N + GN +TA D EN A+ ++ I K+
Sbjct: 638 SLTN--------------SGIKNGNFALRITA--TDGENLADP-MSINISVLHGKVSSKS 680
Query: 393 LFLIQTYAGMLQLAKQSLKKQDTPQYNLTIEVSDKDFKTLCFVQINVIDINDQIPIFEKS 452
+T K +K + + NL E DF IN Q P F+KS
Sbjct: 681 FSCRETRVAQKLAEKLLIKAKANGKLNL--EDGFLDF----------YSINRQGPYFDKS 728
Query: 453 DYGNLTLAEDTNIGSTILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGY 512
++ + ED +G+ IL I+A DAD F G K+L+ I G+++ +D + TG
Sbjct: 729 FPSDVAVKEDLPVGANILKIKAYDADSGFNG--KVLFTISDGNTDSCFNIDME----TGQ 782
Query: 513 VIIKKPLDFETA---AVSNIVFKAENPEPLVFGVKYNASSFAKFTLIVTDVNE-APQFSQ 568
+ + P+D E ++ ++ NP+ SS+ T+ V D N+ +P F Q
Sbjct: 783 LKVLMPMDREHTDLYLLNITIYDLGNPQ---------KSSWRLLTINVEDANDNSPVFIQ 833
Query: 569 HVFQAKVSEDVAIGTKVGNVTAKDPE---GLDISYSLRGDTRGWLKIDHVTGEIFSVAPL 625
+ + E IGT++ V A+D + +++YS+ DT+ + I+ TG ++ L
Sbjct: 834 DSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQF-AINSSTGIVYVADQL 892
Query: 626 DREAGSPYRVQVVATE--VGGSSLSSVSEFHLILMDVNDNPPRLAKDYTGLFFCHPLSAP 683
DRE+ + Y +++ A + G L SV + L DVND P + L
Sbjct: 893 DRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPV- 951
Query: 684 GSLIFEATDDDQHLFRGPHFTFSLGSGSLQNDWEVSKINGTHARLSTRHTEFEEREYVVL 743
G++I D L G +SL +E+ K +G RLS +++ Y +
Sbjct: 952 GTVIAWLETHDPDLGLGGQVRYSL-VNDYNGRFEIDKASGA-IRLSKELDYEKQQFYNLT 1009
Query: 744 IRINDGGRP 752
+R D GRP
Sbjct: 1010 VRAKDKGRP 1018
Score = 125 bits (313), Expect = 2e-28
Identities = 162/620 (26%), Positives = 267/620 (43%), Gaps = 68/620 (10%)
Query: 64 GETDNIFVIERE-GLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDN 122
G TD+ F I+ E G L +DRE + L + D +TI V+D NDN
Sbjct: 768 GNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDN 827
Query: 123 RPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQI 182
P F+Q Y ++ ++S G + V A D D NG++ Y + + + F I
Sbjct: 828 SPVFIQDSYSVNILESSGIGTEIIQVEARDKD--LGSNGEVTYSV------LTDTQQFAI 879
Query: 183 NNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTT-SVDIIVTENIWKA 241
N+ TG + + + +L+ +Y+L I +D + FS T V + + A
Sbjct: 880 NSSTGIVYV----ADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPA 935
Query: 242 PKPVEMVENSTDPHPIKITQVRW---NDPG------AQYSLVDKEKLPRFPFSIDQ-EGD 291
P + P+ T + W +DP +YSLV+ F ID+ G
Sbjct: 936 FIPSSYSVKVLEDLPVG-TVIAWLETHDPDLGLGGQVRYSLVNDY---NGRFEIDKASGA 991
Query: 292 IYVTQPLDREEKDAYVFYAVAKDEYGKP--LSYPLEIHVKVKDINDN--PPTCPSPVTVF 347
I +++ LD E++ Y AKD+ G+P LS + V+V D+N+N P P V
Sbjct: 992 IRLSKELDYEKQQFYNLTVRAKDK-GRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVG 1050
Query: 348 EVQENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAK 407
V+EN R+G S+ +TA RDE++ + + Y I + + G F I +G++ A
Sbjct: 1051 SVKENSRIGTSVLQVTA--RDEDSGRDGEIQYSIRDGSGL----GRFSIDDESGVI-TAA 1103
Query: 408 QSLKKQDTPQYNLTIEVSDKDFKTL---CFVQINVIDINDQIPIFEKSDYGNLTLAEDTN 464
L ++ Y LT+ +D+ L V I V D+ND P+ + Y + + E++
Sbjct: 1104 DILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVM-ENSP 1162
Query: 465 IGSTILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYV-IIKKPLDFET 523
+++ IQA D D + + K+ Y I G+ + + + TG + + LD E
Sbjct: 1163 KDVSVIQIQAEDPDS--SSNEKLTYRITSGNPQNFFAI----NIKTGLITTTSRKLDREQ 1216
Query: 524 AA--VSNIVFKAENPEPLVFGVKYNASSFAKFTLIVTDVNEAPQFSQHVFQAKVSE--DV 579
A + P P S+ ++ + + PQF + V+Q K+ E
Sbjct: 1217 QAEHFLEVTVTDGGPSP-------KQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRK 1269
Query: 580 AIGTKVGNVTAKDPE---GLDISYSL-RGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRV 635
G + A D + +ISYS+ G+ G ID TG + S AGS +
Sbjct: 1270 KRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQF--TAGSYDIL 1327
Query: 636 QVVATEVGGSSLSSVSEFHL 655
+ A + G SS + H+
Sbjct: 1328 TIKAVDNGRPQKSSTARLHI 1347
Score = 116 bits (291), Expect = 7e-26
Identities = 169/711 (23%), Positives = 287/711 (40%), Gaps = 72/711 (10%)
Query: 76 GLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNRPTFLQSKYEGSV 135
G+LY LD E + H L + D + + V+D ND+ P F YE SV
Sbjct: 1516 GVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASV 1575
Query: 136 RQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQINNKTGAISLTREG 195
+++ G L V A D D N +L Y I N F+I G I++ +E
Sbjct: 1576 FESAALGSAVLQVTALDKD--KGENAELIYTIEAG----NTGNMFKIEPVLGIITICKE- 1628
Query: 196 SQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTENIWKAPKPVEMVENSTDPH 255
P V+S+K + Q S T V I VT + PK + +
Sbjct: 1629 -----PDMTTMGQFVLSIK-VTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNE 1682
Query: 256 PIKI-TQVRWNDPGAQYSLVDKEKLPRFP--FSIDQEGDIYVTQ-PLDREEKDAYVFYAV 311
+ I T V +Q +L+ + K F+I+ + TQ LD E +Y
Sbjct: 1683 NVDIGTSVILISAISQSTLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQ 1742
Query: 312 AKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERLGNSI-----GTLTAHD 366
A + G ++ +++++ D NDN P + E + + + L
Sbjct: 1743 ATNMAG--MASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRA 1800
Query: 367 RDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTPQYNLTIEVSD 426
D ++ N+ L Y+IVE T K F + + G ++ +L + ++ + V D
Sbjct: 1801 TDADSNRNALLVYQIVESTAK----KFFTVDSSTGAIRTI-ANLDHETIAHFHFHVHVRD 1855
Query: 427 KDFKTLCF-----VQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQATDADEPF 481
L V I V D+ND P+F ++ + + L T +G +L + ATD D
Sbjct: 1856 SGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLL-PTYVGVEVLKVSATDPDSEV 1914
Query: 482 TGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVSNIVFKAENPEPLVF 541
++ Y +++G + L +D +N+G + IK +N+ + + +
Sbjct: 1915 --PPELTYSLMEGSLDHFL-ID----SNSGVLTIKN---------NNL-----SKDHYML 1953
Query: 542 GVKYNASSFAKFTLIVTDVNEAP----QFSQHVFQAKVSEDVAIGTKVGNVTAKDPE-GL 596
VK + F +++ V EA F+Q + +SE+ TKV V A
Sbjct: 1954 IVKVSDGKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAVGNRLNE 2013
Query: 597 DISYSLRGDTRGWLKIDHVTGEIFSV-APLDREAGSPYRVQVVATEVGGSSLSSVSEFHL 655
+ YS+ + KI +G I + P DRE Y + V A+ + +
Sbjct: 2014 PLKYSILNPGNKF-KIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRV 2072
Query: 656 ILMDVNDNPPRLAKDYTGLFFCHPL---SAPGSLIFEATDDDQHLFRGPHFTFSLGSGSL 712
+ D+NDN P + GL + + + PG+LI++ T D+ +GP+ +
Sbjct: 2073 NIEDINDNSP----VFVGLPYYAAVQVDAEPGTLIYQVTAIDKD--KGPNGEVTYVLQDD 2126
Query: 713 QNDWEVSKINGTHARLSTRHTEFEEREYVVLIRINDGGRPPLEGIVSLPVT 763
+E++ +G +++ EY V I DGG+P L V LP+T
Sbjct: 2127 YGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPIT 2177
Score = 96.7 bits (239), Expect = 8e-20
Identities = 119/463 (25%), Positives = 204/463 (44%), Gaps = 45/463 (9%)
Query: 38 IYEGQEPSQIIFQFKANPP------AVTFELTGETDNIFVIERE-GLLYYNRALDRETRS 90
+YE ++ + +A P V + L +F I+ G++ + LDRE +S
Sbjct: 3140 VYENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSGIIILEQPLDREQQS 3199
Query: 91 THNLQVAALDAN-GIIVEGPVPITIKVKDINDNRPTFLQSKYEGSVRQNSRPGKPFLYVN 149
++N+ V A D + G + +TI V DINDN P F + Y +V +++ PG L V
Sbjct: 3200 SYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVF 3259
Query: 150 ATDLDDPATPNGQLYYQIVIQLPMINNVMYFQINNKTGAISLTREGSQELNPAKNPSYNL 209
AT D N ++ Y I N F+IN KTG IS++ EL + L
Sbjct: 3260 ATSKD--IGTNAEITYLIRSG----NEQGKFKINPKTGGISVSEVLDYELCKR----FYL 3309
Query: 210 VISVKDMGGQSENSFSDTTSVDIIVTENIWKAPKPVEMVENST--------DPHPIKITQ 261
V+ KD G + S +V+I +T+ PK + V ++ D + I +
Sbjct: 3310 VVEAKDGGTPA---LSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAE 3366
Query: 262 VRWNDPGAQ--YSLVDKEKLPRFPFSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYGK 318
+ P Q +S+V+ ++ F ++D G + V + LDRE Y A D
Sbjct: 3367 DVDSQPNGQIHFSIVNGDRDNEF--TVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIP 3424
Query: 319 PLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERLGNSIGTLTAHDRDEENTANSFLN 378
+S +++ + D+NDN P +QEN+ +G SI L DRD + F +
Sbjct: 3425 AMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPF-S 3483
Query: 379 YRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTPQYNLTIEVSDK---DFKTLCFV 435
+ I+ + F++ + G+L+ A + ++ +Y L ++ D + ++
Sbjct: 3484 FSILSGNE----EEEFVLDPH-GILRSA-VVFQHTESLEYVLCVQAKDSGKPQQVSHTYI 3537
Query: 436 QINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQATDAD 478
++ VI+ + P + +T+ ED G I I ATD D
Sbjct: 3538 RVRVIEESTHKPTAIPLEIFIVTM-EDDFPGGVIGKIHATDQD 3579
Score = 87.0 bits (214), Expect = 6e-17
Identities = 151/717 (21%), Positives = 279/717 (38%), Gaps = 120/717 (16%)
Query: 65 ETDNIFVIEREGLLYYNRALDRETRSTHNLQVAALDA-------NGIIVEGPVPITIKVK 117
+ D V G++ + L+ + ++ ++L++ A+D NG V + + ++
Sbjct: 200 KVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNG--VSSTAKLYVHIE 257
Query: 118 DINDNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNV 177
IN++ PT + V + + V DLDD A NG++ ++ ++
Sbjct: 258 RINEHAPTIHVVTH---VPFSLEKEPTYAVVTVDDLDDGA--NGEIESVSIVAGDPLDQ- 311
Query: 178 MYFQINNKTGAISLTREGSQELNPAKNP-SYNLVISVKDMGGQSE----------NSFSD 226
+F + ++++ P YNL + KD G + N D
Sbjct: 312 -FFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRD 370
Query: 227 TTSV-------DIIVTENIWKAPKPVEMVENSTDPHPIKITQVRWNDPGAQYSLVDKEKL 279
T + D+ ++E +P V + P PI + +Y L E
Sbjct: 371 TVPIRFEKEVYDVSISEF---SPPGVVVAIVKLSPEPIDV----------EYKLSPGEDA 417
Query: 280 PRFPFSIDQEGDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPT 339
F + + G I +PL+ +K+ Y K+ K ++ + ++D ND+ P
Sbjct: 418 VYFKIN-PRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKA-----QVTISIEDANDHTPE 471
Query: 340 CPSPVTVFEVQENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTY 399
P+ V E+ +G S+ T++A D+D+ N ++ Y I LP F+I +
Sbjct: 472 FQQPLYDAYVNESVPVGTSVLTVSASDKDKGE--NGYITYSIASLN-LLP----FVINQF 524
Query: 400 AGMLQLAKQSLKKQDTPQ-YNLTIEVSD----KDFKTLCFVQINVIDINDQIPIFEKSDY 454
G++ ++ L + +P+ Y + SD ++ V I + ++ND P+FEK
Sbjct: 525 TGVISTTEE-LDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVAC 583
Query: 455 GNLTLAEDTNIGSTILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVI 514
+ ++ D +G I + A D DE + Y II G+ G ++ D +G +
Sbjct: 584 QGV-ISYDFPVGGHITAVSAIDIDE----LELVKYKIISGNELGFFYLNPD----SGVLQ 634
Query: 515 IKKPLDFETAAVSNIVFK-----AEN-PEPLVFGV-----KYNASSF-----------AK 552
+KK L N + EN +P+ + K ++ SF A+
Sbjct: 635 LKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAE 694
Query: 553 FTLIVTDVN-----------------EAPQFSQHV-FQAKVSEDVAIGTKVGNVTAKDPE 594
LI N + P F + V ED+ +G + + A D +
Sbjct: 695 KLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDAD 754
Query: 595 ----GLDISYSLRGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSLSSV 650
G + G+T ID TG++ + P+DRE Y + + ++G SS
Sbjct: 755 SGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSW 814
Query: 651 SEFHLILMDVNDNPPRLAKDYTGLFFCHPLSAPGSLIFEATDDDQHLFRGPHFTFSL 707
+ + D NDN P +D + S G+ I + D+ L T+S+
Sbjct: 815 RLLTINVEDANDNSPVFIQDSYSVNILES-SGIGTEIIQVEARDKDLGSNGEVTYSV 870
Score = 68.9 bits (167), Expect = 2e-11
Identities = 132/547 (24%), Positives = 226/547 (41%), Gaps = 85/547 (15%)
Query: 84 LDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNRPTFLQSKYEGSVRQNSRPGK 143
L+RE + + L V G +E + I+V D+ND RP F + Y ++ +++
Sbjct: 117 LNREIQDNYLLIVKG-SVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRT 175
Query: 144 PFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQINNKTGAISLTREGSQELNPAK 203
V ATD D NG+ YY N V F ++ +G ISL S LN +
Sbjct: 176 SVAQVTATDAD--IGSNGEFYYYFK------NKVDLFSVHPTSGVISL----SGRLNYDE 223
Query: 204 NPSYNLVISVKDMGGQ--SENSFSDTTSVDIIVTENIWKAP--KPVEMVENSTDPHP-IK 258
Y+L I D G + N S T + + + AP V V S + P
Sbjct: 224 KNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYA 283
Query: 259 ITQVRWNDPGA-----QYSLVDKEKLPRFPFSIDQEGDIYVTQPLDREEKDAYVFYAVAK 313
+ V D GA S+V + L + F + +EG ++ + +E K
Sbjct: 284 VVTVDDLDDGANGEIESVSIVAGDPLDQ--FFLAKEGK-WLNEYKIKERKQI-------- 332
Query: 314 DEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERLGNSIGTLTAHDRDEENTA 373
D P Y L + K K +P C + V+ +GN ++E
Sbjct: 333 DWESFPYGYNLTLQAKDK---GSPQKCSALKAVY-------IGNPTRDTVPIRFEKEVYD 382
Query: 374 NSFLNY-------RIVEQTPKLPMD-----------GLFLIQTYAGMLQLAK--QSLKKQ 413
S + IV+ +P+ P+D F I +G++ A+ ++KK+
Sbjct: 383 VSISEFSPPGVVVAIVKLSPE-PIDVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKE 441
Query: 414 DTPQYNLTIEVSDKDFKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQ 473
Y L EV++K+ V I++ D ND P F++ Y + + E +G+++LT+
Sbjct: 442 ---VYKL--EVTNKEGDLKAQVTISIEDANDHTPEFQQPLY-DAYVNESVPVGTSVLTVS 495
Query: 474 ATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETA-AVSNIVFK 532
A+D D+ G I Y I + + + TG + + LDFE++ + + +
Sbjct: 496 ASDKDKGENG--YITYSIASLNL-----LPFVINQFTGVISTTEELDFESSPEIYRFIVR 548
Query: 533 AENPEPLVFGVKYNASSFAKFTLIVTDVNE-APQFSQHVFQAKVSEDVAIGTKVGNVTAK 591
A + +G Y S T+ + +VN+ +P F + Q +S D +G + V+A
Sbjct: 549 ASD-----WGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAI 603
Query: 592 DPEGLDI 598
D + L++
Sbjct: 604 DIDELEL 610
Score = 58.2 bits (139), Expect = 3e-08
Identities = 93/467 (19%), Positives = 190/467 (40%), Gaps = 40/467 (8%)
Query: 298 LDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERLGN 357
L+RE +D Y+ V G+ L +++++V D+ND P + E+ L
Sbjct: 117 LNREIQDNYLLI-VKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRT 175
Query: 358 SIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTPQ 417
S+ +TA D D + + + K +D LF + +G++ L+ + L + +
Sbjct: 176 SVAQVTATDADIGSNGEFYYYF-------KNKVD-LFSVHPTSGVISLSGR-LNYDEKNR 226
Query: 418 YNLTIEVSDKDFK--------TLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTI 469
Y+L I D+ K + + +++ IN+ P + +L ++ T
Sbjct: 227 YDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKE----PTY 282
Query: 470 LTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVI-IKKPLDFETAAVS- 527
+ D D+ G + + I+ GD + + + Y I +K +D+E+
Sbjct: 283 AVVTVDDLDDGANGEIESV-SIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGY 341
Query: 528 NIVFKAENPEPLVFGVKYNASSFAKFTLIVTDVNEAP-QFSQHVFQAKVSEDVAIGTKVG 586
N+ +A++ G S+ + + P +F + V+ +SE G V
Sbjct: 342 NLTLQAKDK-----GSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVA 396
Query: 587 NVTAKDPEGLDISYSLR-GDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGS 645
+ PE +D+ Y L G+ + KI+ +G I + PL+ Y+++V E G
Sbjct: 397 -IVKLSPEPIDVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKE--GD 453
Query: 646 SLSSVSEFHLILMDVNDNPPRLAKDYTGLFFCHPLSAPGSLIFEATDDDQHLFRGPHFTF 705
+ V+ + + D ND+ P + + + G+ + + D+ + T+
Sbjct: 454 LKAQVT---ISIEDANDHTPEFQQPLYDAYVNESVPV-GTSVLTVSASDKDKGENGYITY 509
Query: 706 SLGSGSLQNDWEVSKINGTHARLSTRHTEFEEREYVVLIRINDGGRP 752
S+ S +L + +++ G + E Y ++R +D G P
Sbjct: 510 SIASLNLL-PFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSP 555
>gi|16445393 cadherin 12, type 2 preproprotein [Homo sapiens]
Length = 794
Score = 196 bits (498), Expect = 7e-50
Identities = 166/566 (29%), Positives = 269/566 (47%), Gaps = 43/566 (7%)
Query: 284 FSIDQE-GDIYVTQPLDREEKDAYVFYAVAKD-EYGKPLSYPLEIHVKVKDINDNPPTCP 341
F+ID+ GDI+ + LDREEK Y A A D E KPL E +KV+DINDN P
Sbjct: 102 FTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFL 161
Query: 342 SPVTVFEVQENERLGNSIGTLTAHDRDEENTANSF-LNYRIVEQTPKLPMDGLFLIQTYA 400
V V E +G + + A D D+ NS + Y I++ P F I
Sbjct: 162 DGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQP------YFSIDPKT 215
Query: 401 GMLQLAKQSLKKQDTPQYNLTIEVSDKDFKT-----LCFVQINVIDINDQIPIFEKSDYG 455
G+++ A ++ ++ QY + I+ D + V I + D+ND P F KS +
Sbjct: 216 GVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIF- 274
Query: 456 NLTLAEDTNIGSTILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVII 515
+L + E + IGS I I+A D D F +++I Y+I+ GD + TD T G + +
Sbjct: 275 HLKVPESSPIGSAIGRIRAVDPD--FGQNAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKL 332
Query: 516 KKPLDFETAAVSNIVFKAENPEPLVFGVKYNASSFAKFT----LIVTDVNEAPQFSQHVF 571
KKPLDFET +A N L +++++ K T + V DV+E P FS+ ++
Sbjct: 333 KKPLDFETKKAYTFKVEASN---LHLDHRFHSAGPFKDTATVKISVLDVDEPPVFSKPLY 389
Query: 572 QAKVSEDVAIGTKVGNVTAKDPEGLDISYSL-------RGDTRGWLKIDHVTGEIFSVAP 624
+V ED +GT +G VTA+D LD+ S + D + ID G I +
Sbjct: 390 TMEVYEDTPVGTIIGAVTAQD---LDVGSSAVRYFIDWKSDGDSYFTIDGNEGTIATNEL 446
Query: 625 LDREAGSPYRVQVVATEVGGSSLSSVSEFHLILMDVNDNPPRLAKDYTGLFFCHPLSAPG 684
LDRE+ + Y ++A++V L+S + ++DVN+ PP ++ Y C + PG
Sbjct: 447 LDRESTAQYNFSIIASKVSNPLLTSKVNILINVLDVNEFPPEISVPYE-TAVCEN-AKPG 504
Query: 685 SLIFEATDDDQHLF-RGPHFTFSLG-SGSLQNDWEVSKINGTHARLSTRHTEFEERE--- 739
+I + D+ L G F+F L +++ ++ V A + TR + R+
Sbjct: 505 QIIQIVSAADRDLSPAGQQFSFRLSPEAAIKPNFTVRDFRNNTAGIETRRNGYSRRQQEL 564
Query: 740 YVVLIRINDGGRPPLEGIVSLPVTFCSCVEGSCFRPAGHQTGIPTVGMAVGILLTTLLVI 799
Y + + I D P ++ + C C + VG++ G L+ LL I
Sbjct: 565 YFLPVVIEDSSYPVQSSTNTMTIRVCRCDSDGTILSCNVEAIFLPVGLSTGALIAILLCI 624
Query: 800 GIILAVV--FIRIKKDKGKDNVESAQ 823
I+LA+V ++ +++ K KD + +++
Sbjct: 625 VILLAIVVLYVALRRQKKKDTLMTSK 650
Score = 134 bits (337), Expect = 3e-31
Identities = 139/471 (29%), Positives = 209/471 (44%), Gaps = 52/471 (11%)
Query: 39 YEGQEPS---QIIFQFKANPPAVTFELTGE-TDNIFVI-EREGLLYYNRALDRETRSTHN 93
Y G EP ++ V + L+G+ +F I E G ++ R+LDRE + +
Sbjct: 67 YVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDREEKPFYT 126
Query: 94 LQVAALDANGII-VEGPVPITIKVKDINDNRPTFLQSKYEGSVRQNSRPGKPFLYVNATD 152
L+ A+D +E IKV+DINDN P FL Y +V + S G L V ATD
Sbjct: 127 LRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATD 186
Query: 153 LDDPATPN-GQLYYQIVIQLPMINNVMYFQINNKTGAISLTREGSQELNPAKNPSYNLVI 211
DDP N ++ Y I+ P YF I+ KTG I R ++ Y ++I
Sbjct: 187 ADDPTYGNSARVVYSILQGQP------YFSIDPKTGVI---RTALPNMDREVKEQYQVLI 237
Query: 212 SVKDMGGQSENSFSDTTSVDIIVT---ENIWKAPKPV-EMVENSTDPHPIKITQVRWNDP 267
KDMGGQ + TT V+I +T +N + PK + + + P I ++R DP
Sbjct: 238 QAKDMGGQL-GGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDP 296
Query: 268 G------AQYSLVDKEKLPRFPFSID---QEGDIYVTQPLDREEKDAYVFYAVAKDEY-- 316
+Y++V + F D QEG I + +PLD E K AY F A + +
Sbjct: 297 DFGQNAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLD 356
Query: 317 -----GKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERLGNSIGTLTAHDRDEEN 371
P + + V D+ D PP P+ EV E+ +G IG +TA D D +
Sbjct: 357 HRFHSAGPFKDTATVKISVLDV-DEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGS 415
Query: 372 TA-NSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTPQYNLTI---EVSDK 427
+A F+++ K D F I G + + L ++ T QYN +I +VS+
Sbjct: 416 SAVRYFIDW-------KSDGDSYFTIDGNEGTI-ATNELLDRESTAQYNFSIIASKVSNP 467
Query: 428 DFKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQATDAD 478
+ + INV+D+N+ P E S + E+ G I + A D D
Sbjct: 468 LLTSKVNILINVLDVNEFPP--EISVPYETAVCENAKPGQIIQIVSAADRD 516
>gi|32880203 cadherin-like 24 isoform 2 [Homo sapiens]
Length = 781
Score = 196 bits (497), Expect = 1e-49
Identities = 161/551 (29%), Positives = 258/551 (46%), Gaps = 34/551 (6%)
Query: 284 FSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYG-KPLSYPLEIHVKVKDINDNPPTCP 341
F ID+ G+I+VT+ LDREEK YV A A D +PL P E +KV+DINDNPP P
Sbjct: 92 FVIDEATGNIHVTKSLDREEKAQYVLLAQAVDRASNRPLEPPSEFIIKVQDINDNPPIFP 151
Query: 342 SPVTVFEVQENERLGNSIGTLTAHDRDEENTANSF-LNYRIVEQTPKLPMDGLFLIQTYA 400
V E +G S+ +TAHD D+ + NS L Y +++ P F +
Sbjct: 152 LGPYHATVPEMSNVGTSVIQVTAHDADDPSYGNSAKLVYTVLDGLP------FFSVDPQT 205
Query: 401 GMLQLAKQSLKKQDTPQYNLTIEVSDK-----DFKTLCFVQINVIDINDQIPIFEKSDYG 455
G+++ A ++ ++ ++ + I+ D V + + D+ND P F +S Y
Sbjct: 206 GVVRTAIPNMDRETQEEFLVVIQAKDMGGHMGGLSGSTTVTVTLSDVNDNPPKFPQSLY- 264
Query: 456 NLTLAEDTNIGSTILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVII 515
++ E G+ + ++A D D ++ + Y I+ G+ + TD G + +
Sbjct: 265 QFSVVETAGPGTLVGRLRAQDPD--LGDNALMAYSILDGEGSEAFSISTDLQGRDGLLTV 322
Query: 516 KKPLDFETAAVSNIVFKAENPEPLVFGVKYNASSF---AKFTLIVTDVNEAPQFSQHVFQ 572
+KPLDFE+ + F+ E L+ F A + V D E P F+Q +
Sbjct: 323 RKPLDFESQ--RSYSFRVEATNTLIDPAYLRRGPFKDVASVRVAVQDAPEPPAFTQAAYH 380
Query: 573 AKVSEDVAIGTKVGNVTAKDPE--GLDISYSL--RGDTRGWLKIDHVTGEIFSVAPLDRE 628
V E+ A GT VG ++A D + I YS+ D I G I + APLDRE
Sbjct: 381 LTVPENKAPGTLVGQISAADLDSPASPIRYSILPHSDPERCFSIQPEEGTIHTAAPLDRE 440
Query: 629 AGSPYRVQVVATEVGGSSLSSVSEFHLILMDVNDNPPRLAKDYTGLFFCHPLSAPGSLI- 687
A + + + V+ATE+ S+ +S + + +D NDN P+LA+ Y F C +APG LI
Sbjct: 441 ARAWHNLTVLATELDSSAQASRVQVAIQTLDENDNAPQLAEPY-DTFVCDS-AAPGQLIQ 498
Query: 688 -FEATDDDQHLFRGPHFTFSLGSGSLQNDWEVSKINGTHA-RLSTRHTEFEEREYVVLIR 745
A D D+ + H +F G N +G+ + L +R Y+V I
Sbjct: 499 VIRALDRDE-VGNSSHVSFQGPLGPDANFTVQDNRDGSASLLLPSRPAPPRHAPYLVPIE 557
Query: 746 INDGGRPPLEGIVSLPVTFCSCVEGSCFRPAGHQTGIPTVGMAVGILLTTLLVIGIILA- 804
+ D G+P L ++ V+ C C + + G++ G LL + +G +LA
Sbjct: 558 LWDWGQPALSSTATVTVSVCRCQPDGSVASCWPEAHLSAAGLSTGALLAIITCVGALLAL 617
Query: 805 -VVFIRIKKDK 814
V+F+ +++ K
Sbjct: 618 VVLFVALRRQK 628
Score = 112 bits (280), Expect = 1e-24
Identities = 124/446 (27%), Positives = 198/446 (44%), Gaps = 49/446 (10%)
Query: 62 LTGE-TDNIFVI-EREGLLYYNRALDRETRSTHNLQVAALD-ANGIIVEGPVPITIKVKD 118
LTGE +FVI E G ++ ++LDRE ++ + L A+D A+ +E P IKV+D
Sbjct: 83 LTGEGAGTVFVIDEATGNIHVTKSLDREEKAQYVLLAQAVDRASNRPLEPPSEFIIKVQD 142
Query: 119 INDNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPN-GQLYYQIVIQLPMINNV 177
INDN P F Y +V + S G + V A D DDP+ N +L Y ++ LP
Sbjct: 143 INDNPPIFPLGPYHATVPEMSNVGTSVIQVTAHDADDPSYGNSAKLVYTVLDGLP----- 197
Query: 178 MYFQINNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDII---V 234
+F ++ +TG + R ++ + +VI KDMGG S +T+V + V
Sbjct: 198 -FFSVDPQTGVV---RTAIPNMDRETQEEFLVVIQAKDMGGHM-GGLSGSTTVTVTLSDV 252
Query: 235 TENIWKAPKPVEM--VENSTDPHPIKITQVRWNDPG------AQYSLVDKEKLPRFPFSI 286
+N K P+ + V + P + + ++R DP YS++D E F S
Sbjct: 253 NDNPPKFPQSLYQFSVVETAGPGTL-VGRLRAQDPDLGDNALMAYSILDGEGSEAFSIST 311
Query: 287 D---QEGDIYVTQPLDREEKDAYVFYAVAKDEY-------GKPLSYPLEIHVKVKDINDN 336
D ++G + V +PLD E + +Y F A + P + V V+D +
Sbjct: 312 DLQGRDGLLTVRKPLDFESQRSYSFRVEATNTLIDPAYLRRGPFKDVASVRVAVQDAPE- 370
Query: 337 PPTCPSPVTVFEVQENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLI 396
PP V EN+ G +G ++A D D + S + Y I+ P + F I
Sbjct: 371 PPAFTQAAYHLTVPENKAPGTLVGQISAADLD---SPASPIRYSIL---PHSDPERCFSI 424
Query: 397 QTYAGMLQLAKQSLKKQDTPQYNLTIEVSDKDFKTLCF---VQINVIDINDQIPIFEKSD 453
Q G + A L ++ +NLT+ ++ D V I +D ND P + ++
Sbjct: 425 QPEEGTIHTA-APLDREARAWHNLTVLATELDSSAQASRVQVAIQTLDENDNAP--QLAE 481
Query: 454 YGNLTLAEDTNIGSTILTIQATDADE 479
+ + + G I I+A D DE
Sbjct: 482 PYDTFVCDSAAPGQLIQVIRALDRDE 507
>gi|4826673 cadherin 6, type 2 preproprotein [Homo sapiens]
Length = 790
Score = 193 bits (491), Expect = 5e-49
Identities = 159/550 (28%), Positives = 255/550 (46%), Gaps = 30/550 (5%)
Query: 287 DQEGDIYVTQPLDREEKDAYVFYAVAKDEY-GKPLSYPLEIHVKVKDINDNPPTCPSPVT 345
+ GDI T+ LDREEK Y+ A A + G+P+ E +K+ DINDN P V
Sbjct: 105 ENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVY 164
Query: 346 VFEVQENERLGNSIGTLTAHDRDEENTANSF-LNYRIVEQTPKLPMDGLFLIQTYAGMLQ 404
V E +G + +TA D D+ NS + Y I++ P F +++ G+++
Sbjct: 165 TATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQP------YFSVESETGIIK 218
Query: 405 LAKQSLKKQDTPQYNLTIEVSDKD-----FKTLCFVQINVIDINDQIPIFEKSDYGNLTL 459
A ++ +++ QY + I+ D V I + D+ND P F +S Y T
Sbjct: 219 TALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKT- 277
Query: 460 AEDTNIGSTILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPL 519
E + G+ I I+A+DAD +++I Y I G+ V TD T G + +KK L
Sbjct: 278 PESSPPGTPIGRIKASDAD--VGENAEIEYSITDGEGLDMFDVITDQETQEGIITVKKLL 335
Query: 520 DFETAAVSNIVFKAENP--EPLVFGVKYNASSFAKFTLIVTDVNEAPQFSQHVFQAKVSE 577
DFE V + +A NP EP + S A ++V DV+E P FS+ + ++ E
Sbjct: 336 DFEKKKVYTLKVEASNPYVEPRFLYLGPFKDS-ATVRIVVEDVDEPPVFSKLAYILQIRE 394
Query: 578 DVAIGTKVGNVTAKDPEGL--DISYSL--RGDTRGWLKIDHVTGEIFSVAPLDREAGSPY 633
D I T +G+VTA+DP+ + YS+ D ID G IF+ LDRE +
Sbjct: 395 DAQINTTIGSVTAQDPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWH 454
Query: 634 RVQVVATEVGGSSLSSVSEFHLILMDVNDNPPRLAKDYTGLFFCHPLSAPGSLIFEATDD 693
+ V+ATE+ SS ++ ++DVNDN P A+ Y F C A + D
Sbjct: 455 NITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEFYE-TFVCEKAKADQLIQTLHAVD 513
Query: 694 DQHLFRGPHFTFSLG-SGSLQNDWEVSKINGTHARLSTRHTEFEERE---YVVLIRINDG 749
+ G F+FSL + +++ + A + TR + E Y++ + I+D
Sbjct: 514 KDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLLPVVISDN 573
Query: 750 GRPPLEGIVSLPVTFCSCVEGSCFRPAGHQTGIPTVGMAVGILLTTLLVIGIIL--AVVF 807
P ++ V C+C + + I G++ G L+ LL I I+L V+F
Sbjct: 574 DYPVQSSTGTVTVRVCACDHHGNMQSCHAEALIHPTGLSTGALVAILLCIVILLVTVVLF 633
Query: 808 IRIKKDKGKD 817
+++ + K+
Sbjct: 634 AALRRQRKKE 643
Score = 138 bits (348), Expect = 2e-32
Identities = 130/479 (27%), Positives = 215/479 (44%), Gaps = 46/479 (9%)
Query: 64 GETDNIFVIEREGLLYYNRALDRETRSTHNLQVAALDAN-GIIVEGPVPITIKVKDINDN 122
G D + E G + + LDRE + + L+ A++ G VE IK+ DINDN
Sbjct: 96 GAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDN 155
Query: 123 RPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPN-GQLYYQIVIQLPMINNVMYFQ 181
P F + Y +V + S G + V ATD DDP N ++ Y I+ P YF
Sbjct: 156 EPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQP------YFS 209
Query: 182 INNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTENIWKA 241
+ ++TG I + ++ Y +VI KDMGGQ S TT+V+I +T+
Sbjct: 210 VESETGII---KTALLNMDRENREQYQVVIQAKDMGGQM-GGLSGTTTVNITLTDVNDNP 265
Query: 242 PK------PVEMVENSTDPHPIKITQVRWNDPG----AQYSLVDKEKLPRFPFSID---Q 288
P+ + E+S PI + D G +YS+ D E L F D Q
Sbjct: 266 PRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGLDMFDVITDQETQ 325
Query: 289 EGDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPL-------EIHVKVKDINDNPPTCP 341
EG I V + LD E+K Y A + Y +P L + + V+D+ D PP
Sbjct: 326 EGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDV-DEPPVFS 384
Query: 342 SPVTVFEVQENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAG 401
+ +++E+ ++ +IG++TA D D A + + Y + T MD +F I + G
Sbjct: 385 KLAYILQIREDAQINTTIGSVTAQDPD---AARNPVKYSVDRHT---DMDRIFNIDSGNG 438
Query: 402 MLQLAKQSLKKQDTPQYNLTI---EVSDKDFKTLCFVQINVIDINDQIPIFEKSDYGNLT 458
+ +K L ++ +N+T+ E+++ + + I V+D+ND P F +++
Sbjct: 439 SIFTSK-LLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEF--AEFYETF 495
Query: 459 LAEDTNIGSTILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKK 517
+ E I T+ A D D+P++G + + + + G D NT ++ +K
Sbjct: 496 VCEKAKADQLIQTLHAVDKDDPYSG-HQFSFSLAPEAASGSNFTIQDNKDNTAGILTRK 553
Score = 60.1 bits (144), Expect = 8e-09
Identities = 50/168 (29%), Positives = 78/168 (46%), Gaps = 4/168 (2%)
Query: 54 NPPAVTFELTGETDNIFVIER-EGLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPI 112
NP + + + D IF I+ G ++ ++ LDRET HN+ V A + N VP+
Sbjct: 415 NPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPL 474
Query: 113 TIKVKDINDNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLP 172
IKV D+NDN P F + YE V + ++ + ++A D DDP + + Q + + +
Sbjct: 475 YIKVLDVNDNAPEFAEF-YETFVCEKAKADQLIQTLHAVDKDDPYSGH-QFSFSLAPEAA 532
Query: 173 MINNVMYFQINNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQS 220
+N Q N A LTR+ + +VIS D QS
Sbjct: 533 SGSN-FTIQDNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQS 579
>gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo
sapiens]
Length = 3312
Score = 192 bits (489), Expect = 8e-49
Identities = 202/715 (28%), Positives = 303/715 (42%), Gaps = 66/715 (9%)
Query: 74 REGLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNRPTFLQSKYEG 133
+ GL+ ALDRE+ H L+V A D + + + V D ND+ P F Q++Y
Sbjct: 381 QSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRE 440
Query: 134 SVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIV-IQLPMINNVMYFQINNKTGAISLT 192
++R+N G P L + ATD D P PN L Y+ V F+I+ ++G IS +
Sbjct: 441 TLRENVEEGYPILQLRATDGDAP--PNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTS 498
Query: 193 REGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTENIWKAP-----KPVEM 247
+E SY LV+ D GQ S T V I V + AP + V
Sbjct: 499 GRVDRE----HMESYELVVEASDQ-GQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQ 553
Query: 248 VENSTDPHPIKITQVRWNDPG------AQYSLVDKEKLPRFPFSIDQ-EGDIYVTQPLDR 300
V PH + + +V D Y+++ R F+ID G+I V PLD
Sbjct: 554 VREDVRPHTV-VLRVTATDRDKDANGLVHYNIISGNS--RGHFAIDSLTGEIQVVAPLDF 610
Query: 301 EEKDAYVFYAVAKDEYGKPLSYPLEI-HVKVKDINDNPPTCPSPVTVFEVQENERLGNSI 359
E + Y A+D PLS + ++V DIND+ P S V EN LG+S+
Sbjct: 611 EAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSV 670
Query: 360 GTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTPQYN 419
+ A D D + N+ L Y + P P F+I + G + ++ L ++ Y
Sbjct: 671 IHIQAVDAD--HGENARLEYSLTGVAPDTP----FVINSATGWVSVS-GPLDRESVEHYF 723
Query: 420 LTIEVSDKDFKTL---CFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQATD 476
+E D L V + V+D+ND P F +Y +L L ED +G++++++ A D
Sbjct: 724 FGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEY-HLRLNEDAAVGTSVVSVTAVD 782
Query: 477 ADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVSNIVFKAENP 536
D +S I Y I G++ R + T G V + PLD++ +V A +
Sbjct: 783 RD----ANSAISYQITGGNTRNRFAIST--QGGVGLVTLALPLDYKQERYFKLVLTASDR 836
Query: 537 EPLVFGVKYNASSFAKFTLIVTDVN-EAPQFSQHVFQAKVSEDVAIGTKVGNVTAKDP-- 593
+ +TD N P F + V+ED +G+ + ++A D
Sbjct: 837 A---------LHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDV 887
Query: 594 -EGLDISYSLRGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSLSSVSE 652
E I+Y L D +ID +G I APLD E Y + + A + G + +
Sbjct: 888 GENARITYLLE-DNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTY 946
Query: 653 FHLILMDVNDNPPR-LAKDYTGLFFCHPLSAPGSLIFEATDDDQHLFRGPHFTFSLGSGS 711
+++ DVNDN P+ +A YTGL L ATD D H +TF G
Sbjct: 947 VEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDG 1006
Query: 712 LQNDWEVSKING---THARLSTRHTE-FEEREYVVLIRINDGGRPPLEGIVSLPV 762
D+ + +G T RL +E Y V D G PPL VS+ V
Sbjct: 1007 -DGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAV-----DRGVPPLRTPVSIQV 1055
Score = 192 bits (489), Expect = 8e-49
Identities = 192/694 (27%), Positives = 319/694 (45%), Gaps = 63/694 (9%)
Query: 74 REGLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVK----DINDNRPTFLQS 129
R GL+ + +DRE ++ L V A D GP T++V D NDN P F +
Sbjct: 491 RSGLISTSGRVDREHMESYELVVEASDQGQ--EPGPRSATVRVHITVLDENDNAPQFSEK 548
Query: 130 KYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQINNKTGAI 189
+Y VR++ RP L V ATD D A NG ++Y I+ N+ +F I++ TG I
Sbjct: 549 RYVAQVREDVRPHTVVLRVTATDRDKDA--NGLVHYNIISG----NSRGHFAIDSLTGEI 602
Query: 190 SLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDII-VTENI---WKAPKPV 245
+ L+ Y L I +D G ++ + S+ ++ + ++I P V
Sbjct: 603 QVVAP----LDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQV 658
Query: 246 EMVENSTDPHPIKITQVRWNDPGA----QYSLVDKEKLPRFPFSIDQE-GDIYVTQPLDR 300
++EN+ H + Q D G +YSL P PF I+ G + V+ PLDR
Sbjct: 659 SVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVA--PDTPFVINSATGWVSVSGPLDR 716
Query: 301 EEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERLGNSIG 360
E + Y F A+D PLS + V V D+NDN P + E+ +G S+
Sbjct: 717 ESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVV 776
Query: 361 TLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAG--MLQLAKQSLKKQDTPQY 418
++TA DRD ANS ++Y+I + F I T G ++ LA KQ+ +
Sbjct: 777 SVTAVDRD----ANSAISYQITGGNTR----NRFAISTQGGVGLVTLALPLDYKQER-YF 827
Query: 419 NLTIEVSDKDFKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQATDAD 478
L + SD+ C+V IN+ D N P+F+ + Y ++++ ED +GSTI+ I A+D D
Sbjct: 828 KLVLTASDRALHDHCYVHINITDANTHRPVFQSAHY-SVSVNEDRPMGSTIVVISASDDD 886
Query: 479 EPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVSNIVFKAENPEP 538
G + + ++++ D+ + +D D +G + ++ PLD+E + A +
Sbjct: 887 ---VGENARITYLLE-DNLPQFRIDAD----SGAITLQAPLDYEDQVTYTLAITARDN-- 936
Query: 539 LVFGVKYNASSFAKFTLIVTDVNE-APQFSQHVFQAKVSEDVAIGTKVGNVTAKDPEG-- 595
G+ A + ++V DVN+ APQF + VSED T V ++A D +
Sbjct: 937 ---GIPQKADT-TYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHA 992
Query: 596 ---LDISYSLRGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSLSSVSE 652
+ ++ D G I+ +G + +V LDREA S Y + A + G L +
Sbjct: 993 NGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVS 1052
Query: 653 FHLILMDVNDNPPRL-AKDYTGLFFCHPLSAPGSLIFEATDDDQHLFRGPHFTFSLGSGS 711
+++ DVNDN P A+++ S GS++ + T D H + + G+
Sbjct: 1053 IQVMVQDVNDNAPVFPAEEFE--VRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGN 1110
Query: 712 LQNDWEVSKINGTHARLSTRHTEFEEREYVVLIR 745
+ +++ +G L E +EYV++++
Sbjct: 1111 IPELFQMDIFSGELTALIDLDYE-ARQEYVIVVQ 1143
Score = 127 bits (320), Expect = 3e-29
Identities = 176/717 (24%), Positives = 297/717 (41%), Gaps = 79/717 (11%)
Query: 62 LTGETDNIFVIER-EGLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPI-TIKVKDI 119
++G + F I+ G + LD E + L++ A DA + + +I+V DI
Sbjct: 585 ISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDI 644
Query: 120 NDNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMY 179
ND+ P F+ + ++ SV +N+ G +++ A D D N +L Y + P
Sbjct: 645 NDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGE--NARLEYSLTGVAPDTP---- 698
Query: 180 FQINNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTENIW 239
F IN+ TG +S+ S L+ Y + +D G ++ + T + V +N
Sbjct: 699 FVINSATGWVSV----SGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRP 754
Query: 240 KAPKPVEMVENSTDP----HPIKITQV-RWNDPGAQYSLVDKEKLPRFPFSIDQE-GDIY 293
+ + + D + +T V R + Y + RF S G +
Sbjct: 755 EFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFAISTQGGVGLVT 814
Query: 294 VTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENE 353
+ PLD +++ + A D + L +H+ + D N + P S V E+
Sbjct: 815 LALPLDYKQERYFKLVLTASD---RALHDHCYVHINITDANTHRPVFQSAHYSVSVNEDR 871
Query: 354 RLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQ 413
+G++I ++A D D A + Y + + P+ F I +G + L + L +
Sbjct: 872 PMGSTIVVISASDDDVGENAR--ITYLLEDNLPQ------FRIDADSGAITL-QAPLDYE 922
Query: 414 DTPQYNLTIEVSDKDFKTLC---FVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTIL 470
D Y L I D +V++ V D+ND P F S Y L ++ED +++L
Sbjct: 923 DQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGL-VSEDAPPFTSVL 981
Query: 471 TIQATDADEPFTGSSKILYHIIKG-DSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVSNI 529
I ATD D G ++ Y G D +G ++ +G V + LD E +V +
Sbjct: 982 QISATDRDAHANG--RVQYTFQNGEDGDGDFTIEP----TSGIVRTVRRLDREAVSVYEL 1035
Query: 530 VFKA--ENPEPLVFGVKYNASSFAKFTLIVTDVNE-APQFSQHVFQAKVSEDVAIGTKVG 586
A PL V ++V DVN+ AP F F+ +V E+ +G+ V
Sbjct: 1036 TAYAVDRGVPPLRTPVSIQ--------VMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVA 1087
Query: 587 NVTAKDPE---GLDISYSL-RGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEV 642
+TA DP+ I Y + G+ ++D +GE+ ++ LD EA Y + V AT
Sbjct: 1088 QITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATS- 1146
Query: 643 GGSSLSSVSEFHLILMDVNDNPPRLAKDYTGLFFCH--------PLSAPGSLIFEATDDD 694
+ L S + H+ L+D NDN P L ++ LF + P G + D
Sbjct: 1147 --APLVSRATVHVRLVDQNDNSPVL-NNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVS 1203
Query: 695 QHLFRGPHFTFSLGSGSLQNDWEVSKINGTHARLSTRHTEFEEREYV--VLIRINDG 749
HLF ++F G N+ ++ +N T L R V +L+ + DG
Sbjct: 1204 DHLF----YSFERG-----NELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDG 1251
Score = 105 bits (262), Expect = 2e-22
Identities = 108/408 (26%), Positives = 182/408 (44%), Gaps = 43/408 (10%)
Query: 57 AVTFELTG-ETDNIFVIEREG---LLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPI 112
A+++++TG T N F I +G L+ LD + L + A D + +
Sbjct: 788 AISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDR---ALHDHCYV 844
Query: 113 TIKVKDINDNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLP 172
I + D N +RP F + Y SV ++ G + ++A+D D N ++ Y + LP
Sbjct: 845 HINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASD--DDVGENARITYLLEDNLP 902
Query: 173 MINNVMYFQINNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDI 232
F+I+ +GAI+L L+ +Y L I+ +D G + +DTT V++
Sbjct: 903 Q------FRIDADSGAITL----QAPLDYEDQVTYTLAITARDNGIPQK---ADTTYVEV 949
Query: 233 IVTENIWKAPKPVE-----MVENSTDPHPIKITQVRWNDPGA------QYSLVDKEKLPR 281
+V + AP+ V +V P + Q+ D A QY+ + E
Sbjct: 950 MVNDVNDNAPQFVASHYTGLVSEDAPPFT-SVLQISATDRDAHANGRVQYTFQNGEDGDG 1008
Query: 282 FPFSIDQ-EGDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTC 340
F+I+ G + + LDRE Y A A D PL P+ I V V+D+NDN P
Sbjct: 1009 -DFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVF 1067
Query: 341 PSPVTVFEVQENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYA 400
P+ V+EN +G+ + +TA D DE N+ + Y+IVE + LF + ++
Sbjct: 1068 PAEEFEVRVKENSIVGSVVAQITAVDPDE--GPNAHIMYQIVEGN----IPELFQMDIFS 1121
Query: 401 GMLQLAKQSLKKQDTPQYNLTIEVSDKDFKTLCFVQINVIDINDQIPI 448
G L A L + +Y + ++ + + V + ++D ND P+
Sbjct: 1122 GEL-TALIDLDYEARQEYVIVVQATSAPLVSRATVHVRLVDQNDNSPV 1168
Score = 102 bits (254), Expect = 1e-21
Identities = 117/432 (27%), Positives = 182/432 (42%), Gaps = 37/432 (8%)
Query: 349 VQENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQ 408
V ENE G ++ + A D D + + + L LF I +G+++ A
Sbjct: 334 VPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLE---LFSIDPQSGLIRTAA- 389
Query: 409 SLKKQDTPQYNLTIEVSDKDFKTLC---FVQINVIDINDQIPIFEKSDYGNLTLAEDTNI 465
+L ++ ++ L + D L V + V D ND P+FE++ Y TL E+
Sbjct: 390 ALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRE-TLRENVEE 448
Query: 466 GSTILTIQATDADEPFTGSSKILYHIIKGDSEGRLGV----DTDPHTNTGYVIIKKPLDF 521
G IL ++ATD D P ++ + Y + G R + DP + G + +D
Sbjct: 449 GYPILQLRATDGDAP--PNANLRYRFV-GPPAARAAAAAAFEIDPRS--GLISTSGRVDR 503
Query: 522 ETAAVSNIVFKA----ENPEPLVFGVKYNASSFAKFTLIVTDVNE-APQFSQHVFQAKVS 576
E +V +A + P P S+ + + V D N+ APQFS+ + A+V
Sbjct: 504 EHMESYELVVEASDQGQEPGP--------RSATVRVHITVLDENDNAPQFSEKRYVAQVR 555
Query: 577 EDVAIGTKVGNVTA----KDPEGLDISYSLRGDTRGWLKIDHVTGEIFSVAPLDREAGSP 632
EDV T V VTA KD GL + G++RG ID +TGEI VAPLD EA
Sbjct: 556 EDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAERE 615
Query: 633 YRVQVVATEVGGSSLSSVSEFHLI-LMDVNDNPPRLAKDYTGLFFCHPLSAPGSLIFEAT 691
Y +++ A + G LS+ + I ++D+ND+ P + S+I
Sbjct: 616 YALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQA 675
Query: 692 DDDQHLFRGPHFTFSLGSGSLQNDWEVSKINGTHARLSTRHTEFEEREYVVLIRINDGGR 751
D H +SL + + ++ G + E E Y + D G
Sbjct: 676 VDADH-GENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEH-YFFGVEARDHGS 733
Query: 752 PPLEGIVSLPVT 763
PPL S+ VT
Sbjct: 734 PPLSASASVTVT 745
Score = 54.7 bits (130), Expect = 3e-07
Identities = 56/208 (26%), Positives = 91/208 (43%), Gaps = 20/208 (9%)
Query: 561 NEAPQFSQHVFQAKVSEDVAIGTKVGNVTAKDPEGLD---ISYSL----RGDTRGWLKID 613
N PQF Q+ +Q V E+ A GT V V A+DP+ + + YSL + ID
Sbjct: 320 NRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSID 379
Query: 614 HVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSLSSVSEFHLILMDVNDNPPRLAK-DYT 672
+G I + A LDRE+ + ++V A + G LS+ + + + D ND+ P + Y
Sbjct: 380 PQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYR 439
Query: 673 GLFFCHPLSAPGSLIFEATDDD-------QHLFRGPHFTFSLGSGSLQNDWEVSKINGTH 725
+ L ATD D ++ F GP + + + + D S + T
Sbjct: 440 ETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEID-PRSGLISTS 498
Query: 726 ARLSTRHTEFEEREYVVLIRINDGGRPP 753
R+ H E Y +++ +D G+ P
Sbjct: 499 GRVDREHME----SYELVVEASDQGQEP 522
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 190 bits (482), Expect = 5e-48
Identities = 187/689 (27%), Positives = 305/689 (44%), Gaps = 65/689 (9%)
Query: 63 TGETDNIFVIER-EGLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDIND 121
TG+ +F I + G L +DRE +S + L+V A +G V G + I VKD+ND
Sbjct: 832 TGDQKGMFAINQVTGQLTTANVIDREEQSFYQLKVVA---SGGTVTGDTMVNITVKDLND 888
Query: 122 NRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQ 181
N P FLQ+ +V +N + G A D D+ NG + Y + N F
Sbjct: 889 NSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGV--NGMVLYSL-----KQNPKNLFA 941
Query: 182 INNKTGAISLTREGSQELNPAKNPSYNLVISVKDMG-GQSENSFSDTTSVDIIVTENIWK 240
IN K G ISL G +++ SY + I DMG Q +S T V + +
Sbjct: 942 INEKNGTISLL--GPLDVHAG---SYQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVF 996
Query: 241 APKPVEMVENSTDPHPIKITQVRWNDPGA----QYSLVDKEKLPRFPFSIDQEGDIYVTQ 296
E+ + ++P + +V+ +D + + + E F I +G +Y+
Sbjct: 997 DQLSYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGIFPDGQLYIKS 1056
Query: 297 PLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERLG 356
LDRE +D YV VA D +PLS + + V ++D+NDN P S F +E +R G
Sbjct: 1057 ELDRELQDRYVLMVVASDRAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAG 1116
Query: 357 NSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSL-KKQDT 415
+ +G ++A D+D ++ +V+ +L + T+ Q ++SL +++ T
Sbjct: 1117 SFVGKVSAVDKDFGPNGEVRYSFEMVQPDFELHAISGEITNTH----QFDRESLMRRRGT 1172
Query: 416 PQYNLTIEVSD----KDFKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILT 471
++ T+ +D + K V + + DIND P F K D+ T++E + +L
Sbjct: 1173 AVFSFTVIATDQGIPQPLKDQATVHVYMKDINDNAPKFLK-DFYQATISESAANLTQVLR 1231
Query: 472 IQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVSNIVF 531
+ A+D DE G I Y IIKG+ E + +D + +G V + LD+E ++V
Sbjct: 1232 VSASDVDEGNNG--LIHYSIIKGNEERQFAID----STSGQVTLIGKLDYEATPAYSLVI 1285
Query: 532 KAENPEPLVFGVKYNASSFAKFTLIVTDVNE-APQFSQHVFQAKVSEDVAIGTKVGNVTA 590
+A + + +S + + D N+ P F + V E++ IG V +VTA
Sbjct: 1286 QAVDSGTIPL------NSTCTLNIDILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTA 1339
Query: 591 KDP---EGLDISYSLRG-DTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSS 646
D + D+ YS+ G + G I TG IF LD E S Y++ + A + G
Sbjct: 1340 TDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPP 1399
Query: 647 LSSVSEFHLILMDVNDNPPRLAKDYTGLFFCHPLSAP-GSLIFEATDDD----------- 694
SS + + D NDNPP +F + P G+ + T D
Sbjct: 1400 RSSTMSVVIHVRDFNDNPPSFPPG--DIFKSIVENIPIGTSVISVTAHDPDADINGQLSY 1457
Query: 695 ---QHLFRGPHFTFSLGSGSLQNDWEVSK 720
Q + RG HFT G++ + E+ +
Sbjct: 1458 TIIQQMPRGNHFTIDEVKGTIYTNAEIDR 1486
Score = 170 bits (430), Expect = 6e-42
Identities = 194/750 (25%), Positives = 311/750 (41%), Gaps = 78/750 (10%)
Query: 31 LKPMTFSIYEGQEPSQIIFQFKANPPA------VTFELTGETDNIFVIER-EGLLYYNRA 83
L P I E ++F+ +A P + + L N F I +G +
Sbjct: 2052 LSPKLTYIPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNKFSIGTIDGEVRLTGE 2111
Query: 84 LDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNRPTFLQSKYEGSVRQNSRPGK 143
LDRE S + L V A D + + + V DINDN P F Q+ Y+ + +N+ G
Sbjct: 2112 LDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGT 2171
Query: 144 PFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQINNKTGAISLTREGSQELNPAK 203
+ V A D D+ NGQ+ Y IV N F+I++ TGAI++ + +E K
Sbjct: 2172 DIIQVFAADGDEGT--NGQVRYGIVNG----NTNQEFRIDSVTGAITVAKPLDRE----K 2221
Query: 204 NPSYNLVISVKDMGGQSENSFSDTTSVDIIVTEN------IWKAPKPVEMVEN-STDPHP 256
P+Y+L + D G +DT++V I++ + +P V + EN T P
Sbjct: 2222 TPTYHLTVQATDRGSTPR---TDTSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRT 2278
Query: 257 IKITQVRWNDPGA--QYSLVDKEKLPRFPFSIDQEGDIYVTQPLDREEKDAYVFYAVAKD 314
I R +D G+ + S V F++ G++ VTQ LDRE K+ +V A D
Sbjct: 2279 ILQVVARDDDRGSNSKLSYVLFGGNEDNAFTLSASGELGVTQSLDRETKERFVLMITATD 2338
Query: 315 EYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERLGNSIGTLTAHDRDEENTAN 374
L+ I+V V D+NDN PT S + E+ G + + A D D A
Sbjct: 2339 SGSPALTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNA- 2397
Query: 375 SFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTPQYNLTIEVSD----KDFK 430
RI+ + F I G + + L ++ Y L + SD +
Sbjct: 2398 ---VIRIIGGNSQ------FTINPSTGQI-ITSALLDRETKDNYTLVVVCSDAGSPEPLS 2447
Query: 431 TLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQATDADEPFTGSSKILYH 490
+ V + V D+ND P F+ Y + T GS + + TDAD G + L++
Sbjct: 2448 SSTSVLVTVTDVNDNPPRFQHHPYVT-HIPSPTLPGSFVFAVTVTDAD---IGPNSELHY 2503
Query: 491 IIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVSNIVFKAENPEPLVFGVKYNASSF 550
+ G + + +D G ++ PL+ S + F VK + SF
Sbjct: 2504 SLSGRNSEKFHID----PLRGAIMAAGPLN----GASEVTFSVH--------VK-DGGSF 2546
Query: 551 AK---FTLIVTDVNEA--PQFSQHVFQAKVSEDVAIGTKVGNVTAKDPEGLDISYSL-RG 604
K T+ V VN+A P+ E+ + + V +T G +SY + G
Sbjct: 2547 PKTDSTTVTVRFVNKADFPKVRAKEQTFMFPENQPVSSLVTTITGSSLRGEPMSYYIASG 2606
Query: 605 DTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSLSSVSEFHLILMDVNDNP 664
+ +ID +TG++ PLD E Y V + A + G SS + + ++DVNDN
Sbjct: 2607 NLGNTFQIDQLTGQVSISQPLDFEKIQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDNA 2666
Query: 665 PRLAKDYTGLFFCHPLSAPGSLIFEATDDDQHLFRGPH--FTFSLGSGSLQNDWEVSKIN 722
P +D LS L A D D GP+ + + +G+++N + ++
Sbjct: 2667 PIFKEDPFISEILENLSPRKILTVSAMDKDS----GPNGQLDYEIVNGNMENSFSINHAT 2722
Query: 723 GTHARLSTRHTEFEEREYVVLIRINDGGRP 752
G + E + YV+ I+ +D G P
Sbjct: 2723 GEIRSVRPLDRE-KVSHYVLTIKSSDKGSP 2751
Score = 169 bits (427), Expect = 1e-41
Identities = 183/718 (25%), Positives = 317/718 (44%), Gaps = 73/718 (10%)
Query: 76 GLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNRPTFLQSKYEGSV 135
G + +R L+RE + ++V+A D+ + +TI V DINDN P F ++ Y
Sbjct: 2825 GDIVISRPLNREDTDRYRIRVSAHDSGWTV---STDVTIFVTDINDNAPRFSRTSYYLDC 2881
Query: 136 RQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQINNKTGAI----SL 191
+ + G V ATD D+ + NGQ++Y I Q YF+IN TG I L
Sbjct: 2882 PELTEIGSKVTQVFATDPDEGS--NGQVFYFIKSQSE------YFRINATTGEIFNKQIL 2933
Query: 192 TREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTENIWKAPKPVE----- 246
+ + ++ +++ D G + S T+V I + ++ AP+ ++
Sbjct: 2934 KYQNVTGFSNVNINRHSFIVTSSDRG---KPSLISETTVTINIVDSNDNAPQFLKSKYFT 2990
Query: 247 -MVEN-STDPHPIKITQVRWNDPG----AQYSLVDKEKLPRFPFSIDQEGDIYVTQPLDR 300
+ +N I++T + D G +Y + + L +F D G I V L
Sbjct: 2991 PVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKFKLDND-TGWISVASSLIS 3049
Query: 301 EEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERLGNSIG 360
+ + AKD+ PLS +H+ V + N + P + E+ +G+ +
Sbjct: 3050 DLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEFSQSHMSATIPESHSIGSIVR 3109
Query: 361 TLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTPQYNL 420
T++A DRD N + Y I +G+F I + G+L LAK +L + ++ +
Sbjct: 3110 TVSARDRDA--AMNGLIKYSISSGNE----EGIFAINSSTGILTLAK-ALDYELCQKHEM 3162
Query: 421 TIEVSDKDFKT---LCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQATDA 477
TI D + C V +NVID+ND P+F DY T+ E+ G+T++ + ATDA
Sbjct: 3163 TISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFP-TVLENAPSGTTVIHLNATDA 3221
Query: 478 DEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVSNIVFKAEN-P 536
D +G++ ++ + ++ +D NTG + + LDFET ++ KA N P
Sbjct: 3222 D---SGTNAVIAYTVQSSDSDLFVID----PNTGVITTQGFLDFETKQSYHLTVKAFNVP 3274
Query: 537 EPLVFGVKYNASSFAKFTLIVTDVNE-APQFSQHVFQAKVSEDVAIGTKVGNVTAKDPE- 594
+ SFA + + NE P+F ++ ++SE GT VG V A D +
Sbjct: 3275 DE-------ERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDL 3327
Query: 595 GLD--ISYSLRGDTR-GWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSLSSVS 651
G D + Y + G++R +I+ TG+I+ LDRE ++V+A G + +
Sbjct: 3328 GTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREKEERVSLKVLAKNFGSIRGADID 3387
Query: 652 E--FHLILMDVNDNPPRLAKDYTGLFFCHPLSAPGSLIFEATDDDQHLFRGPHFTFSLGS 709
E ++ ++D ND PP + + + + F + D + F++ +GS
Sbjct: 3388 EVTVNVTVLDAND-PPIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGS 3446
Query: 710 GSLQNDWEVSKINGTHARLSTRHTEFEEREYVVLIRIN----DGGRPPLEGIVSLPVT 763
G+ + ++ G T +RE + + ++ D G P G SL VT
Sbjct: 3447 GNENGAFSINPQTG-----QITVTAELDRETLPIYNLSVLAVDSGTPSATGSASLLVT 3499
Score = 166 bits (420), Expect = 8e-41
Identities = 199/726 (27%), Positives = 315/726 (43%), Gaps = 77/726 (10%)
Query: 63 TGETDNIFVIEREGLLYYNRALDRETRSTHNLQVAALDANGIIVE---GPVPITIKVKDI 119
+G++ F +++ G+L +ALDRE++S +NL V D I ++I + D+
Sbjct: 1985 SGDSLGQFTVDKNGVLKVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDV 2044
Query: 120 NDNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMY 179
NDN PTFL K + +N+ ATD D + PN + Y ++ P+ N
Sbjct: 2045 NDNPPTFLSPKLT-YIPENTPIDTVVFKAQATDPD--SGPNSYIEYTLL--NPLGNK--- 2096
Query: 180 FQINNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTEN-- 237
F I G + LT EL+ + +Y L + D G S +S ++ + + + +N
Sbjct: 2097 FSIGTIDGEVRLT----GELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNP 2152
Query: 238 -IWKAPKPVEMVENSTDPHPIKITQVRWNDPG----AQYSLVDKEKLPRFPFSIDQEGDI 292
+A VE+ EN+ I D G +Y +V+ F G I
Sbjct: 2153 IFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRID-SVTGAI 2211
Query: 293 YVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQEN 352
V +PLDRE+ Y A D P + + + + DIND P ++ + V
Sbjct: 2212 TVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVSIVLLDINDFVPV--FELSPYSVNVP 2269
Query: 353 ERLGNSIGT-LTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLK 411
E LG T L RD++ +NS L+Y + D F + +G L + QSL
Sbjct: 2270 ENLGTLPRTILQVVARDDDRGSNSKLSYVLFGGNE----DNAFTLSA-SGELGVT-QSLD 2323
Query: 412 KQDTPQYNLTIEVSDKDFKTLCFV-QINVI--DINDQIPIFEKSDYGNLTLAEDTNIGST 468
++ ++ L I +D L INVI D+ND +P F Y T+ ED G+
Sbjct: 2324 RETKERFVLMITATDSGSPALTGTGTINVIVDDVNDNVPTFASKAYFT-TIPEDAPTGTD 2382
Query: 469 ILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVSN 528
+L + A+DAD S + II G+S+ + + +TG +I LD ET
Sbjct: 2383 VLLVNASDAD----ASKNAVIRIIGGNSQFTI------NPSTGQIITSALLDRETKDNYT 2432
Query: 529 IVF---KAENPEPLVFGVKYNASSFAKFTLIVTDVNE-APQFSQHVFQAKVSEDVAIGTK 584
+V A +PEPL SS + VTDVN+ P+F H + + G+
Sbjct: 2433 LVVVCSDAGSPEPL--------SSSTSVLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSF 2484
Query: 585 VGNVTAKDPE---GLDISYSLRGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATE 641
V VT D + ++ YSL G ID + G I + PL+ + + V V
Sbjct: 2485 VFAVTVTDADIGPNSELHYSLSGRNSEKFHIDPLRGAIMAAGPLNGASEVTFSVHV---- 2540
Query: 642 VGGSSLSSVSEFHLILMDVN--DNPPRLAKDYTGLFFCHPLSAP-GSLIFEATDDDQHLF 698
G S + + VN D P AK+ T +F P + P SL+ T
Sbjct: 2541 KDGGSFPKTDSTTVTVRFVNKADFPKVRAKEQTFMF---PENQPVSSLVTTITGSS---L 2594
Query: 699 RGPHFTFSLGSGSLQNDWEVSKINGTHARLSTRHTEFEE-REYVVLIRINDGGRPPLEGI 757
RG ++ + SG+L N +++ ++ G + ++ +FE+ ++YVV I DGG PP
Sbjct: 2595 RGEPMSYYIASGNLGNTFQIDQLTGQVS--ISQPLDFEKIQKYVVWIEARDGGFPPFSSY 2652
Query: 758 VSLPVT 763
L +T
Sbjct: 2653 EKLDIT 2658
Score = 166 bits (419), Expect = 1e-40
Identities = 195/730 (26%), Positives = 327/730 (44%), Gaps = 89/730 (12%)
Query: 68 NIFVIER-EGLLYYNRALDRETRSTHNLQVAALDANGIIVE----GPVPITIKVKDINDN 122
N F I+ +G +Y N +DRE + L V A D + +E +TI V D+NDN
Sbjct: 1467 NHFTIDEVKGTIYTNAEIDREFANLFELTVKAND-QAVPIETRRYALKNVTILVTDLNDN 1525
Query: 123 RPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQI 182
P F+ S+ + ++ G + A D D+ A NG++ Y+I I
Sbjct: 1526 VPMFI-SQNALAADPSAVIGSVLTTIMAADPDEGA--NGEIEYEI--------------I 1568
Query: 183 NNKTGAISLTR-EGSQELNPAKNPS---YNLVISVKDMGGQSENSFSDTTSVDIIVTENI 238
N T + R G + A PS YNL++S D+G + S ++ T + + +
Sbjct: 1569 NGDTDTFIVDRYSGDLRVASALVPSQLIYNLIVSATDLGPERRKSTTELTIILQGLDGPV 1628
Query: 239 WKAPKPVEMVENS----TDPHPIKITQVRWNDPGAQYSLVD---KEKLPRFPFSIDQEGD 291
+ PK + +++ T+ I+ R ++ +Y +V +EK F+I +
Sbjct: 1629 FTQPKYITILKEGEPIGTNVISIEAASPRGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTG 1688
Query: 292 IYVTQPLDREEKDAYVF----YAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVF 347
I T + E+ A ++ YA+ K P + E+ + ++DINDNPP P+ +
Sbjct: 1689 IIQTAAILDREQGACLYLVDVYAIEKST-AFPRTQRAEVEITLQDINDNPPVFPTDMLDL 1747
Query: 348 EVQENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAK 407
V+EN G+ I LTA D DE AN+ + Y I+ D F I +G L +A
Sbjct: 1748 TVEENIGDGSKIMQLTAMDADE--GANALVTYTIISGA-----DDSFRIDPESGDL-IAT 1799
Query: 408 QSLKKQDTPQYNLTIEVSDKDFKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGS 467
+ L ++ +Y+L + D + + I V D+ND P F + Y + + EDT GS
Sbjct: 1800 RRLDRERRSKYSLLVRADDGLQSSDMRINITVSDVNDHTPKFSRPVY-SFDIPEDTIPGS 1858
Query: 468 TILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVS 527
+ I ATD D G +I Y + + D +G + + TG + + LD+E
Sbjct: 1859 LVAAILATDDDSGVNG--EITYIVNEDDEDGIFFL----NPITGVFNLTRLLDYEVQQYY 1912
Query: 528 NIVFKAENPEPLVFGVKYNASSFAKFTLI-----VTDVNEAPQ-FSQHVFQAKVSEDVAI 581
+ +AE+ +FT I + DVN+ P FS + + + E++ +
Sbjct: 1913 ILTVRAED-------------GGGQFTTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPV 1959
Query: 582 GTK--VGNVT-AKDPEGLDISYSL-RGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQV 637
G+ V NVT A D ++YS+ GD+ G +D G + + LDRE+ S Y + V
Sbjct: 1960 GSTVLVFNVTDADDGINSQLTYSIASGDSLGQFTVDK-NGVLKVLKALDRESQSFYNLVV 2018
Query: 638 VA---TEVGGSSLSSVSEFHLILMDVNDNPPR-LAKDYTGLFFCHPLSAP-GSLIFEATD 692
++ S +S ++ +IL+DVNDNPP L+ T + P + P +++F+A
Sbjct: 2019 QVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKLTYI----PENTPIDTVVFKAQA 2074
Query: 693 DDQHLFRGPHFTFSLGSGSLQNDWEVSKINGTHARLSTRHTEFEEREYVVLIRINDGGRP 752
D + ++L L N + + I+G RL+ E Y + + D G+P
Sbjct: 2075 TDPDSGPNSYIEYTL-LNPLGNKFSIGTIDG-EVRLTGELDREEVSNYTLTVVATDKGQP 2132
Query: 753 PLEGIVSLPV 762
L + V
Sbjct: 2133 SLSSSTEVVV 2142
Score = 163 bits (413), Expect = 5e-40
Identities = 197/773 (25%), Positives = 337/773 (43%), Gaps = 84/773 (10%)
Query: 36 FSIYEGQEPSQIIFQFKANPPAVTFELTGETDNIFVIERE-GLLYYNRALDRETRSTHNL 94
F + E Q P ++ + P T+ L+ E+ +F I G LY +DRE+ + +
Sbjct: 49 FQVLEEQPPGTLVGTIQTRP-GFTYRLS-ESHALFAINSSTGALYTTSTIDRESLPSDVI 106
Query: 95 QVAALDANGIIVEGPVPITIKVKDINDNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLD 154
+ L + P + + V+D+NDN P F + +++S G+ + ATD D
Sbjct: 107 NLVVLSSAPTY---PTEVRVLVRDLNDNAPVFPDPSIVVTFKEDSSSGRQVILDTATDSD 163
Query: 155 DPATPNGQLYYQIVIQLPMINNVMYFQIN---NKTGA---ISLTREGSQELNPAKNPSYN 208
+ Y+I+ N F+++ N +G + L +G L+ P Y
Sbjct: 164 IGSNGVDHRSYRIIRG----NEAGRFRLDITLNPSGEGAFLHLVSKGG--LDREVTPQYQ 217
Query: 209 LVISVKDMGGQSENSFS--DTTSVDI-----IVTENIWKAPKPVEMVENSTDPHPIKITQ 261
L++ V+D G + + T DI + + ++A P + V S+
Sbjct: 218 LLVEVEDKGEPKRRGYLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADA 277
Query: 262 VRWNDPGAQYSLVDKEKLPRFPFSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYGKPL 320
+ +Y L D+ PF +D E G I V +PLD E + Y A D L
Sbjct: 278 DEGTNADIRYRLQDEGT----PFQMDPETGLITVREPLDFEARRQYSLTVQAMDRGVPSL 333
Query: 321 SYPLEIHVKVKDINDNPPTC-----PSPVTVFEVQENERLGNSIGTLTAHDRDEENTANS 375
+ E +++ D+NDN P P+ V EN ++G + LT D D AN
Sbjct: 334 TGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSP-AANG 392
Query: 376 FLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTPQYNLTIEVSD--------- 426
++ +I+ + + ++++A +L ++ P YNLT+ VSD
Sbjct: 393 NISVQILGGNEQRHFEVQSSKVPNLSLIKVAS-ALDRERIPSYNLTVSVSDNYGAPPGAA 451
Query: 427 -KDFKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQATDADEPFTGSS 485
+ ++ + I V DIND P+F + Y + L+E+ GS + I ATD D ++
Sbjct: 452 VQARSSVASLVIFVNDINDHPPVFSQQVY-RVNLSEEAPPGSYVSGISATDGDSGL--NA 508
Query: 486 KILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAA--VSNIVFKAENPEPLVFGV 543
+ Y I+ G+ G + H+ LD E A+ V NI + + P V
Sbjct: 509 NLRYSIVSGNGLGWFHISE--HSGLVTTGSSGGLDRELASQIVLNISARDQGVHPKV--- 563
Query: 544 KYNASSFAKFTLIVTDVN-EAPQFSQ-HVFQAKVSEDVAIGTKVGNVTAKDPEGLD---I 598
S+A+ + + DVN E P FSQ + V E+ GT++ + A D + D +
Sbjct: 564 -----SYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTELLMLRATDGDLGDNGTV 618
Query: 599 SYSLRG---DTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSLSSVSEFHL 655
+SL+ D R + ++D V+G + +++ LDRE + Y + V+AT++G SS++ ++
Sbjct: 619 RFSLQEAETDRRSF-RLDPVSGRLSTISSLDREEQAFYSLLVLATDLGSPPQSSMARINV 677
Query: 656 ILMDVNDNPPRLAKDYTGLFFCH--PLSAPGSLIFEATDDDQHLFRGPHFTFSLGSGSLQ 713
L+D+NDN P Y +F H GS I + D L +S+ +G
Sbjct: 678 SLLDINDNSPVF---YPVQYFAHIKENEPGGSYITTVSATDPDLGTNGTVKYSISAG--- 731
Query: 714 NDWEVSKINGTHARLSTRHT--EFEEREYVVLIRINDGG--RPPLEGIVSLPV 762
D ++N +STR E+ Y + I DGG + P + IV++ V
Sbjct: 732 -DRSRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTITV 783
Score = 139 bits (350), Expect = 1e-32
Identities = 151/599 (25%), Positives = 258/599 (43%), Gaps = 44/599 (7%)
Query: 180 FQINNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFS--DTTSVDIIVTEN 237
FQI+ TG +S+ SQ L+ K Y + I +D G +S+ D T +D+
Sbjct: 2612 FQIDQLTGQVSI----SQPLDFEKIQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDNAP 2667
Query: 238 IWKAPKPVEMVENSTDPHPIKITQVRWNDPGAQ----YSLVDKEKLPRFPFSIDQEGDIY 293
I+K + + + P I D G Y +V+ F + G+I
Sbjct: 2668 IFKEDPFISEILENLSPRKILTVSAMDKDSGPNGQLDYEIVNGNMENSFSIN-HATGEIR 2726
Query: 294 VTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENE 353
+PLDRE+ YV + D+ S +++ + + D NDN P S + V EN
Sbjct: 2727 SVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILDENDNAPRF-SQIFSAHVPENS 2785
Query: 354 RLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQ 413
LG ++ +T D E+ N+ Y I++ + LP F I G + +++ L ++
Sbjct: 2786 PLGYTVTRVTTSD--EDIGINAISRYSIMDAS--LP----FTINPSTGDIVISRP-LNRE 2836
Query: 414 DTPQYNLTIEVSDKDFKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQ 473
DT +Y + + D + V I V DIND P F ++ Y L E T IGS + +
Sbjct: 2837 DTDRYRIRVSAHDSGWTVSTDVTIFVTDINDNAPRFSRTSY-YLDCPELTEIGSKVTQVF 2895
Query: 474 ATDADEPFTGSSKILYHIIKGDSE-GRLGVDTDPHTNTGYVIIKKPLDFETAAV---SNI 529
ATD DE GS+ +++ IK SE R+ T N + + F + S I
Sbjct: 2896 ATDPDE---GSNGQVFYFIKSQSEYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFI 2952
Query: 530 VFKAENPEPLVFGVKYNASSFAKFTLIVTDVNE-APQFSQHVFQAKVSEDVAIGTKVGNV 588
V ++ +P + S T+ + D N+ APQF + + V+++V +GTK+ V
Sbjct: 2953 VTSSDRGKPSLI-------SETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRV 3005
Query: 589 TAKDPEGL----DISYSLRGDTR-GWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVG 643
TA D + ++ Y + D G K+D+ TG I + L + + + V A + G
Sbjct: 3006 TAIDDKDFGLNSEVEYFISNDNHLGKFKLDNDTGWISVASSLISDLNQNFFITVTAKDKG 3065
Query: 644 GSSLSSVSEFHLILMDVNDNPPRLAKDYTGLFFCHPLSAPGSLIFEATDDDQHLFRGPHF 703
LSS + H+ + + N + P ++ + S GS++ + D+
Sbjct: 3066 NPPLSSQATVHITVTEENYHTPEFSQSHMSATIPESHSI-GSIVRTVSARDRDAAMNGLI 3124
Query: 704 TFSLGSGSLQNDWEVSKINGTHARLSTRHTEFEEREYVVLIRINDGGRPPLEGIVSLPV 762
+S+ SG+ + + ++ G E ++ + + I DGG G S+ V
Sbjct: 3125 KYSISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMTISAI-DGGWVARTGYCSVTV 3182
Score = 138 bits (347), Expect = 2e-32
Identities = 178/729 (24%), Positives = 307/729 (42%), Gaps = 68/729 (9%)
Query: 60 FELTGETDNIFVIEREGLLYYN-RALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKD 118
F + T IF ++ L Y N + H+ V + D + +TI + D
Sbjct: 2918 FRINATTGEIF--NKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIVD 2975
Query: 119 INDNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVM 178
NDN P FL+SKY V +N + G + V A D D N ++ Y I N++
Sbjct: 2976 SNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAID-DKDFGLNSEVEYFISND----NHLG 3030
Query: 179 YFQINNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTENI 238
F+++N TG IS+ +LN ++ + ++ KD G S +V I VTE
Sbjct: 3031 KFKLDNDTGWISVASSLISDLNQ----NFFITVTAKDKGNPP---LSSQATVHITVTEEN 3083
Query: 239 WKAPKPVEMVENSTDPHP------IKITQVRWNDPGA----QYSLVDKEKLPRFPFSIDQ 288
+ P+ + ++T P ++ R D +YS+ + F +
Sbjct: 3084 YHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAIN-SS 3142
Query: 289 EGDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFE 348
G + + + LD E + A D + + V V D+NDN P S
Sbjct: 3143 TGILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPT 3202
Query: 349 VQENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQ 408
V EN G ++ L A D D A ++ T + LF+I G++ Q
Sbjct: 3203 VLENAPSGTTVIHLNATDADSGTNA-------VIAYTVQSSDSDLFVIDPNTGVI--TTQ 3253
Query: 409 SLKKQDTPQ-YNLTIE---VSDKDFKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTN 464
+T Q Y+LT++ V D++ + V I + N+ +P F Y ++E
Sbjct: 3254 GFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLY-YFEISEAAP 3312
Query: 465 IGSTILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETA 524
G+ + + A+D D G+ ++++I G+S + + TG + + LD E
Sbjct: 3313 KGTIVGEVFASDRD---LGTDGEVHYLIFGNSRKK---GFQINKKTGQIYVSGILDREKE 3366
Query: 525 AVSNIVFKAENPEPLVFGVKYNASSFAKFTLIVT--DVNEAPQFSQHVFQAKVSEDVAIG 582
++ A+N FG + + T+ VT D N+ P F+ +++ ++SE V IG
Sbjct: 3367 ERVSLKVLAKN-----FG-SIRGADIDEVTVNVTVLDANDPPIFTLNIYSVQISEGVPIG 3420
Query: 583 TKVGNVTAKDPEGLD----ISYSL-RGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQV 637
T V V+A D + + SY + G+ G I+ TG+I A LDRE Y + V
Sbjct: 3421 THVTFVSAFDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSV 3480
Query: 638 VATEVGGSSLSSVSEFHLILMDVNDNPPRLAKDYTGLFFCHPLSAPGSLI--FEATDDDQ 695
+A + G S + + + L D+NDN P L + PG+L+ ++TD D
Sbjct: 3481 LAVDSGTPSATGSASLLVTLEDINDNGPMLTVSEGEVM---ENKRPGTLVMTLQSTDPDL 3537
Query: 696 HLFRGPHFTFSLGSGSLQNDWEVSKINGTHARLSTRHTEFEE-REYVVLIRINDGGRPPL 754
+GP + L +G + + +S +TR + E+ ++ + + D G P +
Sbjct: 3538 PPNQGPFTYYLLSTGPATSYFSLSTAG---VLSTTREIDREQIADFYLSVVTKDSGVPQM 3594
Query: 755 EGIVSLPVT 763
++ +T
Sbjct: 3595 SSTGTVHIT 3603
Score = 136 bits (342), Expect = 9e-32
Identities = 178/717 (24%), Positives = 298/717 (41%), Gaps = 57/717 (7%)
Query: 64 GETDNIFVIEREGLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNR 123
G+ V + G++ ALDRE ++ + LQ+ A D + +TI V D DN
Sbjct: 731 GDRSRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTITVLDTQDNP 790
Query: 124 PTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQIN 183
P F Q Y V +N G V+A+ +D N + Y I + F IN
Sbjct: 791 PVFSQVAYSFVVFENVALGYHVGSVSASTMD----LNSNISYLITTG----DQKGMFAIN 842
Query: 184 NKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTE------N 237
TG ++ +E + Y L + S + + T V+I V + +
Sbjct: 843 QVTGQLTTANVIDRE----EQSFYQLKVVA------SGGTVTGDTMVNITVKDLNDNSPH 892
Query: 238 IWKAPKPVEMVENSTDPHPIKITQVRWNDPGAQ-YSLVDKEKLPRFPFSIDQE-GDIYVT 295
+A + V +VEN H I + D G L ++ P+ F+I+++ G I +
Sbjct: 893 FLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQNPKNLFAINEKNGTISLL 952
Query: 296 QPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERL 355
PLD +Y +A D LS + + V V D+NDN P + E+E +
Sbjct: 953 GPLD-VHAGSYQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLSYEVTLSESEPV 1011
Query: 356 GNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDT 415
+ + A D+D + AN + Y I E G+F G L + K L ++
Sbjct: 1012 NSRFFKVQASDKD--SGANGEIAYTIAEGNTG-DAFGIF----PDGQLYI-KSELDRELQ 1063
Query: 416 PQYNLTIEVSDKDFKTL-CFVQINVI--DINDQIPIFEKSDYGNLTLAEDTNIGSTILTI 472
+Y L + SD+ + L V + VI D+ND P+F ++Y E+ GS + +
Sbjct: 1064 DRYVLMVVASDRAVEPLSATVNVTVILEDVNDNRPLFNSTNY-TFYFEEEQRAGSFVGKV 1122
Query: 473 QATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVSNIVFK 532
A D D G + + +++ D E L + TNT + + AV +
Sbjct: 1123 SAVDKDFGPNGEVRYSFEMVQPDFE--LHAISGEITNTHQFDRESLMRRRGTAVFSFTVI 1180
Query: 533 AENPEPLVFGVKYNASSFAKFTLIVTDVNE-APQFSQHVFQAKVSEDVAIGTKVGNVTAK 591
A + G+ A + + D+N+ AP+F + +QA +SE A T+V V+A
Sbjct: 1181 ATDQ-----GIPQPLKDQATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSAS 1235
Query: 592 DPE----GLDISYS-LRGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSS 646
D + GL I YS ++G+ ID +G++ + LD EA Y + + A + G
Sbjct: 1236 DVDEGNNGL-IHYSIIKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIP 1294
Query: 647 LSSVSEFHLILMDVNDNPPRLAKDYTGLFFCHPLSAPGSLIFEATDDDQHLFRGPHFTFS 706
L+S ++ ++D NDN P K + + G L+ T D +S
Sbjct: 1295 LNSTCTLNIDILDENDNTPSFPKSTLFVDVLENMRI-GELVSSVTATDSDSGDNADLYYS 1353
Query: 707 LGSGSLQNDWEVSKINGTHARLSTRHTEFEERE-YVVLIRINDGGRPPLEGIVSLPV 762
+ + + +S T + + +FE + Y + I D GRPP +S+ +
Sbjct: 1354 ITGTNNHGTFSISP--NTGSIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVI 1408
Score = 133 bits (334), Expect = 8e-31
Identities = 157/670 (23%), Positives = 273/670 (40%), Gaps = 90/670 (13%)
Query: 35 TFSIYEGQEPSQIIFQFKANPPAVTFELTGETDNIFVIEREGLLYYNRALDRETRSTHNL 94
++ I G E + NP +GE + ++ + GL DRE + L
Sbjct: 173 SYRIIRGNEAGRFRLDITLNP-------SGEGAFLHLVSKGGL-------DREVTPQYQL 218
Query: 95 QVAALDANGIIVEGPVPITIKVKDINDNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLD 154
V D G + + + V+DINDN P F S Y+ V +++ G L V A D D
Sbjct: 219 LVEVEDKGEPKRRGYLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADAD 278
Query: 155 DPATPNGQLYYQIVIQLPMINNVMYFQINNKTGAISLTREGSQELNPAKNPSYNLVISVK 214
+ N + Y++ + FQ++ +TG I++ + L+ Y+L +
Sbjct: 279 EGT--NADIRYRLQ------DEGTPFQMDPETGLITVR----EPLDFEARRQYSLTVQAM 326
Query: 215 DMG-----GQSENSFS--DTTSVDIIVTENIWKAPKPVEMVENSTDPHPIK--ITQVRWN 265
D G G++E D D +V + A V+ + + +T +
Sbjct: 327 DRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDAD 386
Query: 266 DPGAQYSL--------------VDKEKLPRFPFSIDQEGDIYVTQPLDREEKDAYVFYAV 311
P A ++ V K+P I V LDRE +Y
Sbjct: 387 SPAANGNISVQILGGNEQRHFEVQSSKVPNLSL-------IKVASALDRERIPSYNLTVS 439
Query: 312 AKDEYGKPLSYPLEIH-------VKVKDINDNPPTCPSPVTVFEVQENERLGNSIGTLTA 364
D YG P ++ + V DIND+PP V + E G+ + ++A
Sbjct: 440 VSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVSGISA 499
Query: 365 HDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQS-LKKQDTPQYNLTIE 423
D D AN L Y IV G F I ++G++ L ++ Q L I
Sbjct: 500 TDGDSGLNAN--LRYSIVSGNGL----GWFHISEHSGLVTTGSSGGLDRELASQIVLNIS 553
Query: 424 VSDKDFKT-LCFVQ--INVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQATDADEP 480
D+ + + Q + ++D+ND+ P+F + + ++++ E+ G+ +L ++ATD D
Sbjct: 554 ARDQGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTELLMLRATDGDLG 613
Query: 481 FTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAV-SNIVFKAENPEPL 539
G+ + + D R DP + G + LD E A S +V + P
Sbjct: 614 DNGTVRFSLQEAETD---RRSFRLDPVS--GRLSTISSLDREEQAFYSLLVLATDLGSP- 667
Query: 540 VFGVKYNASSFAKFTLIVTDVNE-APQFSQHVFQAKVSEDVAIGTKVGNVTAKDPE---G 595
SS A+ + + D+N+ +P F + A + E+ G+ + V+A DP+
Sbjct: 668 ------PQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGTN 721
Query: 596 LDISYSLRGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSLSSVSEFHL 655
+ YS+ R +++ +G I + LDRE + Y++Q+VAT+ G + + +
Sbjct: 722 GTVKYSISAGDRSRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTI 781
Query: 656 ILMDVNDNPP 665
++D DNPP
Sbjct: 782 TVLDTQDNPP 791
Score = 125 bits (314), Expect = 2e-28
Identities = 173/679 (25%), Positives = 277/679 (40%), Gaps = 84/679 (12%)
Query: 62 LTGETDNIFVIER-EGLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDIN 120
+ G T+ F I+ G + + LDRE T++L V A D ++I + DIN
Sbjct: 2194 VNGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVSIVLLDIN 2253
Query: 121 DNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYF 180
D P F S Y +V +N P + DD N +L Y +
Sbjct: 2254 DFVPVFELSPYSVNVPENLGT-LPRTILQVVARDDDRGSNSKLSYVLFG----------- 2301
Query: 181 QINNKTGAISLTREG----SQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTE 236
N+ A +L+ G +Q L+ + L+I+ D G + + T ++++IV +
Sbjct: 2302 --GNEDNAFTLSASGELGVTQSLDRETKERFVLMITATDSGSPA---LTGTGTINVIVDD 2356
Query: 237 NIWKAPKPVEMVENSTDPHPIK----ITQVRWNDPGAQYSLVDKEKLPRFPFSIDQE-GD 291
P +T P + V +D A + V + F+I+ G
Sbjct: 2357 VNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVIRIIGGNSQFTINPSTGQ 2416
Query: 292 IYVTQPLDREEKDAYVFYAVAKDEYG-KPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQ 350
I + LDRE KD Y V D +PLS + V V D+NDNPP V +
Sbjct: 2417 IITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIP 2476
Query: 351 ENERLGNSIGTLTAHDRDEENTANSFLNYRIV-EQTPKLPMDGLFLIQTYAGMLQLAKQS 409
G+ + +T D D NS L+Y + + K +D L AG L A +
Sbjct: 2477 SPTLPGSFVFAVTVTDADIG--PNSELHYSLSGRNSEKFHIDPLRGAIMAAGPLNGASE- 2533
Query: 410 LKKQDTPQYNLTIEVSDKDFKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDT------ 463
+T V KD + + + K+D+ + E T
Sbjct: 2534 ----------VTFSVHVKDGGSFPKTDSTTVTVR----FVNKADFPKVRAKEQTFMFPEN 2579
Query: 464 -NIGSTILTIQATDA-DEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDF 521
+ S + TI + EP + Y+I G+ +D TG V I +PLDF
Sbjct: 2580 QPVSSLVTTITGSSLRGEPMS------YYIASGNLGNTFQIDQ----LTGQVSISQPLDF 2629
Query: 522 ETAAVSNIVFKAENPEPLVFGVKYNASSFAKFTLIVTDVNE-APQFSQHVFQAKVSEDVA 580
E + +A + F SS+ K + V DVN+ AP F + F +++ E+++
Sbjct: 2630 EKIQKYVVWIEARDGGFPPF------SSYEKLDITVLDVNDNAPIFKEDPFISEILENLS 2683
Query: 581 IGTKVGNVTAKD----PEGLDISYSL-RGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRV 635
K+ V+A D P G + Y + G+ I+H TGEI SV PLDRE S Y +
Sbjct: 2684 -PRKILTVSAMDKDSGPNG-QLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYVL 2741
Query: 636 QVVATEVGGSSLSSVSEFHLILMDVNDNPPRLAKDYTGLFFCH-PLSAP-GSLIFEATDD 693
+ +++ G S S+ + + ++D NDN PR ++ +F H P ++P G + T
Sbjct: 2742 TIKSSDKGSPSQSTSVKVMINILDENDNAPR----FSQIFSAHVPENSPLGYTVTRVTTS 2797
Query: 694 DQHLFRGPHFTFSLGSGSL 712
D+ + +S+ SL
Sbjct: 2798 DEDIGINAISRYSIMDASL 2816
Score = 98.2 bits (243), Expect = 3e-20
Identities = 147/654 (22%), Positives = 260/654 (39%), Gaps = 87/654 (13%)
Query: 94 LQVAALDANGIIVEGPVPITIKVKDINDNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDL 153
+ V A D + + I V + N + P F QS ++ ++ G V+A D
Sbjct: 3057 ITVTAKDKGNPPLSSQATVHITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDR 3116
Query: 154 DDPATPNGQLYYQIVIQLPMINNVMYFQINNKTGAISLTREGSQELNPAKNPSYNLVISV 213
D A NG + Y I N F IN+ TG ++L + EL + + IS
Sbjct: 3117 D--AAMNGLIKYSISSG----NEEGIFAINSSTGILTLAKALDYELCQ----KHEMTISA 3166
Query: 214 KDMGGQSENSFSDTTSVDIIVTEN-------------IWKAPKPVEMVE-NSTDPHPIKI 259
D G + + T I V +N + AP ++ N+TD
Sbjct: 3167 IDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTN 3226
Query: 260 TQVRWNDPGAQYSLVDKEKLPRFPFSIDQEGDIYVTQP-LDREEKDAYVFYAVAKDEYGK 318
+ + + L F ID + TQ LD E K +Y A + +
Sbjct: 3227 AVIAYTVQSSDSDL----------FVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDE 3276
Query: 319 PLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERLGNSIGTLTAHDRDEENTANSFLN 378
+++++K N+ P S + FE+ E G +G + A DRD ++
Sbjct: 3277 ERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGE--VH 3334
Query: 379 YRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTPQYNLTIEVSDKDFKTL------ 432
Y I + K F I G + ++ ++++ ++++V K+F ++
Sbjct: 3335 YLIFGNSRKKG----FQINKKTGQIYVSGILDREKEE---RVSLKVLAKNFGSIRGADID 3387
Query: 433 -CFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQATDADEPFTGSSKILYHI 491
V + V+D ND PIF + Y ++ ++E IG+ + + A D+D S+ Y I
Sbjct: 3388 EVTVNVTVLDANDP-PIFTLNIY-SVQISEGVPIGTHVTFVSAFDSDS-IPSWSRFSYFI 3444
Query: 492 IKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVSNI-VFKAENPEPLVFGVKYNASSF 550
G+ G ++ TG + + LD ET + N+ V ++ P +A+
Sbjct: 3445 GSGNENGAFSINPQ----TGQITVTAELDRETLPIYNLSVLAVDSGTP-------SATGS 3493
Query: 551 AKFTLIVTDVNE-APQFSQHVFQAKVSEDVAIGTKVGNVTAKDPE-----GLDISYSLR- 603
A + + D+N+ P + V + +V E+ GT V + + DP+ G Y L
Sbjct: 3494 ASLLVTLEDINDNGPMLT--VSEGEVMENKRPGTLVMTLQSTDPDLPPNQGPFTYYLLST 3551
Query: 604 GDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSLSSVSEFHLILMDVNDN 663
G + + G + + +DRE + + + VV + G +SS H+ ++D NDN
Sbjct: 3552 GPATSYFSLS-TAGVLSTTREIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVIDQNDN 3610
Query: 664 PPR-----LAKDYTGLFFCHPLSAPGSLIFEATDDDQHLFRGPHFTFSLGSGSL 712
P + + +Y G F PG ++ D + H + + G SL
Sbjct: 3611 PSQSRTVEIFVNYYGNLF------PGGILGSVKPQDPDVLDSFHCSLTSGVTSL 3658
Score = 60.5 bits (145), Expect = 6e-09
Identities = 80/312 (25%), Positives = 121/312 (38%), Gaps = 35/312 (11%)
Query: 73 EREGLLYYNRALDRETRSTHNLQVAALDANGIIVEG--PVPITIKVKDINDNRPTFLQSK 130
++ G +Y + LDRE +L+V A + I V + + V D ND P F +
Sbjct: 3350 KKTGQIYVSGILDREKEERVSLKVLAKNFGSIRGADIDEVTVNVTVLDANDP-PIFTLNI 3408
Query: 131 YEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQINNKTGAIS 190
Y + + G +V+A D D + + Y+ + N F IN +TG I+
Sbjct: 3409 YSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYF-----IGSGNENGAFSINPQTGQIT 3463
Query: 191 LTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSD--TTSVDII------------VTE 236
+T E +E P YNL + D G S + T DI V E
Sbjct: 3464 VTAELDRETLPI----YNLSVLAVDSGTPSATGSASLLVTLEDINDNGPMLTVSEGEVME 3519
Query: 237 NIWKAPKPVEMVENSTDPHPIKITQVRWNDPGAQYSLVDKEKLPRFPFSIDQEGDIYVTQ 296
N K P + M STDP + N Y L+ + FS+ G + T+
Sbjct: 3520 N--KRPGTLVMTLQSTDP------DLPPNQGPFTYYLLSTGPATSY-FSLSTAGVLSTTR 3570
Query: 297 PLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERLG 356
+DRE+ + V KD +S +H+ V D NDNP + N G
Sbjct: 3571 EIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVIDQNDNPSQSRTVEIFVNYYGNLFPG 3630
Query: 357 NSIGTLTAHDRD 368
+G++ D D
Sbjct: 3631 GILGSVKPQDPD 3642
>gi|14589891 cadherin 3, type 1 preproprotein [Homo sapiens]
Length = 829
Score = 189 bits (480), Expect = 9e-48
Identities = 169/631 (26%), Positives = 273/631 (43%), Gaps = 44/631 (6%)
Query: 219 QSENSFSDTTSVDIIVTENIWKAPK------PVEMVENSTDPHPIKITQVRWN---DPGA 269
Q S + + I ++ I + K P+ + EN P P ++ Q++ N D
Sbjct: 82 QERRSLKERNPLKIFPSKRILRRHKRDWVVAPISVPENGKGPFPQRLNQLKSNKDRDTKI 141
Query: 270 QYSLVDK--EKLPRFPFSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEI 326
YS+ + P F++++E G + + +PLDREE Y + A E G + P+ I
Sbjct: 142 FYSITGPGADSPPEGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENGASVEDPMNI 201
Query: 327 HVKVKDINDNPPTCPSPVTVFEVQENERLGNSIGTLTAHDRDEE-NTANSFLNYRIVEQT 385
+ V D ND+ P V E G S+ +TA D D+ T N + Y I Q
Sbjct: 202 SIIVTDQNDHKPKFTQDTFRGSVLEGVLPGTSVMQVTATDEDDAIYTYNGVVAYSIHSQE 261
Query: 386 PKLPMDGLFLIQTYAGMLQLAKQSLKKQDTPQYNLTIEVSDKD---FKTLCFVQINVIDI 442
PK P D +F I G + + L ++ P+Y LTI+ +D D T + ++D
Sbjct: 262 PKDPHDLMFTIHRSTGTISVISSGLDREKVPEYTLTIQATDMDGDGSTTTAVAVVEILDA 321
Query: 443 NDQIPIFEKSDYGNLTLAEDTNIGSTILTIQATDADEPFTGSSKILYHIIKGDSEGRLGV 502
ND P+F+ Y + +G + + TD D P + + + Y I+ GD +
Sbjct: 322 NDNAPMFDPQKYE--AHVPENAVGHEVQRLTVTDLDAPNSPAWRATYLIMGGDDGDHFTI 379
Query: 503 DTDPHTNTGYVIIKKPLDFETAAVSNIVFKAENPEPLVFGVKYNASSFAKFTLIVTDVNE 562
T P +N G + +K LDFE + + N P V + +S A + V DVNE
Sbjct: 380 TTHPESNQGILTTRKGLDFEAKNQHTLYVEVTNEAPFVLKL---PTSTATIVVHVEDVNE 436
Query: 563 APQFSQHVFQAKVSEDVAIGTKVGNVTAKDP--EGLDISYSLRGDTRGWLKIDHVTGEIF 620
AP F +V E + G V TA+DP E ISY + D GWL +D +G++
Sbjct: 437 APVFVPPSKVVEVQEGIPTGEPVCVYTAEDPDKENQKISYRILRDPAGWLAMDPDSGQVT 496
Query: 621 SVAPLDRE-----AGSPYRVQVVATEVGGSSLSSVSEFHLILMDVNDNPPRLAKDYTGLF 675
+V LDRE + Y V V+A + G + L L+DVND+ P + +
Sbjct: 497 AVGTLDREDEQFVRNNIYEVMVLAMDNGSPPTTGTGTLLLTLIDVNDHGP--VPEPRQIT 554
Query: 676 FCHPLSAPGSLIFEATDDDQHLFRGPHFTFSLGSGSLQNDWEVSKINGTHARLSTRHTEF 735
C+ +P + TD D P + EV++ G LS +
Sbjct: 555 ICN--QSPVRQVLNITDKDLSPHTSPFQAQLTDDSDIYWTAEVNE-EGDTVVLSLKKF-L 610
Query: 736 EEREYVVLIRINDGGRPPLEGIVSLPVTFCSC---VEGSCFRPAGHQTGIPTVGMAVGIL 792
++ Y V + ++D G E + + T C C VE +C P +P +G + +L
Sbjct: 611 KQDTYDVHLSLSDHGNK--EQLTVIRATVCDCHGHVE-TCPGPWKGGFILPVLGAVLALL 667
Query: 793 LTTLLVIGIILAVVFIR----IKKDKGKDNV 819
L+++ ++ I+ + +D +DNV
Sbjct: 668 FLLLVLLLLVRKKRKIKEPLLLPEDDTRDNV 698
Score = 120 bits (301), Expect = 5e-27
Identities = 127/437 (29%), Positives = 190/437 (43%), Gaps = 45/437 (10%)
Query: 46 QIIFQFKANPPAVT---FELTGE-----TDNIFVIERE-GLLYYNRALDRETRSTHNLQV 96
Q + Q K+N T + +TG + +F +E+E G L N+ LDRE + + L
Sbjct: 126 QRLNQLKSNKDRDTKIFYSITGPGADSPPEGVFAVEKETGWLLLNKPLDREEIAKYELFG 185
Query: 97 AALDANGIIVEGPVPITIKVKDINDNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDP 156
A+ NG VE P+ I+I V D ND++P F Q + GSV + PG + V ATD DD
Sbjct: 186 HAVSENGASVEDPMNISIIVTDQNDHKPKFTQDTFRGSVLEGVLPGTSVMQVTATDEDDA 245
Query: 157 A-TPNGQLYYQIVIQLPMINNVMYFQINNKTGAISLTREGSQELNPAKNPSYNLVISVKD 215
T NG + Y I Q P + + F I+ TG IS+ G L+ K P Y L I D
Sbjct: 246 IYTYNGVVAYSIHSQEPKDPHDLMFTIHRSTGTISVISSG---LDREKVPEYTLTIQATD 302
Query: 216 MGGQSENSFSDTTSVDII-VTENIWKAPK------PVEMVENSTDPHPIKITQVRWNDPG 268
M G S TT+V ++ + + AP + EN+ ++T + P
Sbjct: 303 MDGDG----STTTAVAVVEILDANDNAPMFDPQKYEAHVPENAVGHEVQRLTVTDLDAPN 358
Query: 269 -----AQYSLVDKEKLPRFPFSIDQE---GDIYVTQPLDREEKDAYVFYAVAKDEYGKPL 320
A Y ++ + F + E G + + LD E K+ + Y +E L
Sbjct: 359 SPAWRATYLIMGGDDGDHFTITTHPESNQGILTTRKGLDFEAKNQHTLYVEVTNEAPFVL 418
Query: 321 SYPLE---IHVKVKDINDNPPTCPSPVTVFEVQENERLGNSIGTLTAHDRDEENTANSFL 377
P I V V+D+N+ P P P V EVQE G + TA D D+EN +
Sbjct: 419 KLPTSTATIVVHVEDVNEAPVFVP-PSKVVEVQEGIPTGEPVCVYTAEDPDKENQK---I 474
Query: 378 NYRIV-EQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTPQYNLTIEVSDKDFKTLC--- 433
+YRI+ + L MD T G L + + + Y + + D
Sbjct: 475 SYRILRDPAGWLAMDPDSGQVTAVGTLDREDEQFVRNNI--YEVMVLAMDNGSPPTTGTG 532
Query: 434 FVQINVIDINDQIPIFE 450
+ + +ID+ND P+ E
Sbjct: 533 TLLLTLIDVNDHGPVPE 549
>gi|16306487 cadherin 7, type 2 preproprotein [Homo sapiens]
Length = 785
Score = 186 bits (471), Expect = 1e-46
Identities = 160/557 (28%), Positives = 248/557 (44%), Gaps = 42/557 (7%)
Query: 284 FSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEY-GKPLSYPLEIHVKVKDINDNPPTCP 341
F ID+ GDI+ T+ LDREE+ Y A A D KP+ E +K++DINDN P
Sbjct: 95 FIIDENTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFL 154
Query: 342 SPVTVFEVQENERLGNSIGTLTAHDRDEENTANSF-LNYRIVEQTPKLPMDGLFLIQTYA 400
V E +G S+ +TA D D+ NS + Y I++ P F ++
Sbjct: 155 DGPYTAGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQP------YFSVEPKT 208
Query: 401 GMLQLAKQSLKKQDTPQYNLTIEVSDK-----DFKTLCFVQINVIDINDQIPIFEKSDYG 455
G+++ A ++ ++ QY L I+ D V + + D+ND P F + Y
Sbjct: 209 GVIKTALPNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSY- 267
Query: 456 NLTLAEDTNIGSTILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVII 515
+ E + S + I+A DAD ++++ Y I+ GD G + D T G + I
Sbjct: 268 QYNVPESLPVASVVARIKAADAD--IGANAEMEYKIVDGDGLGIFKISVDKETQEGIITI 325
Query: 516 KKPLDFETAAVSNIVFKAEN----PEPLVFGVKYNASSFAKFTLIVTDVNEAPQFSQHVF 571
+K LDFE + +A N P L G S +IV DV+E P FS ++
Sbjct: 326 QKELDFEAKTSYTLRIEAANKDADPRFLSLGP---FSDTTTVKIIVEDVDEPPVFSSPLY 382
Query: 572 QAKVSEDVAIGTKVGNVTAKDPEGLD--ISYSL--RGDTRGWLKIDHVTGEIFSVAPLDR 627
+VSE +G +G V A DP+ + + YS+ D + ID +G I + LDR
Sbjct: 383 PMEVSEATQVGNIIGTVAAHDPDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDR 442
Query: 628 EAGSPYRVQVVATEVGGSSLSSVSEFHLILMDVNDNPPRLAKDYTGLFFCHPLSAPGSLI 687
E + + + V+A E S + ++D+NDN P A DY C + PG +I
Sbjct: 443 ETNAIHNITVLAMESQNPSQVGRGYVAITILDINDNAPEFAMDYE-TTVCEN-AQPGQVI 500
Query: 688 --FEATDDDQHLFRGPHFTFSLGSGSLQN-DWEVSKINGTHARLSTRHTEFEERE---YV 741
A D D+ G F FSL + + N ++ + A + TR F +E Y
Sbjct: 501 QKISAVDKDEP-SNGHQFYFSLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYY 559
Query: 742 VLIRINDGGRPPLEGIVSLPVTFCSCVEGSCFRPAGHQTGIPTVGMAVGILLTTL----- 796
+ I I D G P L +L + C C + + + G++ G L+ L
Sbjct: 560 LPIFIVDSGSPSLSSTNTLTIRVCDCDADGVAQTCNAEAYVLPAGLSTGALIAILACVLT 619
Query: 797 LVIGIILAVVFIRIKKD 813
L++ I+L V R KK+
Sbjct: 620 LLVLILLIVTMRRRKKE 636
Score = 160 bits (404), Expect = 6e-39
Identities = 143/454 (31%), Positives = 211/454 (46%), Gaps = 47/454 (10%)
Query: 57 AVTFELTGE-TDNIFVI-EREGLLYYNRALDRETRSTHNLQVAALDA-NGIIVEGPVPIT 113
++ + L+GE +IF+I E G ++ + LDRE ++ + L+ ALD VE
Sbjct: 81 SIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFV 140
Query: 114 IKVKDINDNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPN-GQLYYQIVIQLP 172
IK++DINDN P FL Y V + S G + V ATD DDP N ++ Y I+ P
Sbjct: 141 IKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQP 200
Query: 173 MINNVMYFQINNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDI 232
YF + KTG I + ++ Y LVI KDM GQ+ S TTSV +
Sbjct: 201 ------YFSVEPKTGVI---KTALPNMDREAKDQYLLVIQAKDMVGQN-GGLSGTTSVTV 250
Query: 233 IVTENIWKAPKPVEMVENSTDPHPIKITQVRWN------DPGA----QYSLVDKEKLPRF 282
+T+ P+ P + + V D GA +Y +VD + L F
Sbjct: 251 TLTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKAADADIGANAEMEYKIVDGDGLGIF 310
Query: 283 PFSID---QEGDIYVTQPLDREEKDAYVFYAVAKDEYGK-------PLSYPLEIHVKVKD 332
S+D QEG I + + LD E K +Y A ++ P S + + V+D
Sbjct: 311 KISVDKETQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVED 370
Query: 333 INDNPPTCPSPVTVFEVQENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDG 392
+ D PP SP+ EV E ++GN IGT+ AHD D ++NS + Y I T ++
Sbjct: 371 V-DEPPVFSSPLYPMEVSEATQVGNIIGTVAAHDPD---SSNSPVRYSIDRNT---DLER 423
Query: 393 LFLIQTYAGMLQLAKQSLKKQDTPQYNLTIEVSDKDFKTLC---FVQINVIDINDQIPIF 449
F I +G++ AK SL ++ +N+T+ + + +V I ++DIND P F
Sbjct: 424 YFNIDANSGVITTAK-SLDRETNAIHNITVLAMESQNPSQVGRGYVAITILDINDNAPEF 482
Query: 450 EKSDYGNLTLAEDTNIGSTILTIQATDADEPFTG 483
DY T+ E+ G I I A D DEP G
Sbjct: 483 -AMDY-ETTVCENAQPGQVIQKISAVDKDEPSNG 514
>gi|16306489 cadherin 7, type 2 preproprotein [Homo sapiens]
Length = 785
Score = 186 bits (471), Expect = 1e-46
Identities = 160/557 (28%), Positives = 248/557 (44%), Gaps = 42/557 (7%)
Query: 284 FSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEY-GKPLSYPLEIHVKVKDINDNPPTCP 341
F ID+ GDI+ T+ LDREE+ Y A A D KP+ E +K++DINDN P
Sbjct: 95 FIIDENTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFL 154
Query: 342 SPVTVFEVQENERLGNSIGTLTAHDRDEENTANSF-LNYRIVEQTPKLPMDGLFLIQTYA 400
V E +G S+ +TA D D+ NS + Y I++ P F ++
Sbjct: 155 DGPYTAGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQP------YFSVEPKT 208
Query: 401 GMLQLAKQSLKKQDTPQYNLTIEVSDK-----DFKTLCFVQINVIDINDQIPIFEKSDYG 455
G+++ A ++ ++ QY L I+ D V + + D+ND P F + Y
Sbjct: 209 GVIKTALPNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSY- 267
Query: 456 NLTLAEDTNIGSTILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVII 515
+ E + S + I+A DAD ++++ Y I+ GD G + D T G + I
Sbjct: 268 QYNVPESLPVASVVARIKAADAD--IGANAEMEYKIVDGDGLGIFKISVDKETQEGIITI 325
Query: 516 KKPLDFETAAVSNIVFKAEN----PEPLVFGVKYNASSFAKFTLIVTDVNEAPQFSQHVF 571
+K LDFE + +A N P L G S +IV DV+E P FS ++
Sbjct: 326 QKELDFEAKTSYTLRIEAANKDADPRFLSLGP---FSDTTTVKIIVEDVDEPPVFSSPLY 382
Query: 572 QAKVSEDVAIGTKVGNVTAKDPEGLD--ISYSL--RGDTRGWLKIDHVTGEIFSVAPLDR 627
+VSE +G +G V A DP+ + + YS+ D + ID +G I + LDR
Sbjct: 383 PMEVSEATQVGNIIGTVAAHDPDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDR 442
Query: 628 EAGSPYRVQVVATEVGGSSLSSVSEFHLILMDVNDNPPRLAKDYTGLFFCHPLSAPGSLI 687
E + + + V+A E S + ++D+NDN P A DY C + PG +I
Sbjct: 443 ETNAIHNITVLAMESQNPSQVGRGYVAITILDINDNAPEFAMDYE-TTVCEN-AQPGQVI 500
Query: 688 --FEATDDDQHLFRGPHFTFSLGSGSLQN-DWEVSKINGTHARLSTRHTEFEERE---YV 741
A D D+ G F FSL + + N ++ + A + TR F +E Y
Sbjct: 501 QKISAVDKDEP-SNGHQFYFSLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYY 559
Query: 742 VLIRINDGGRPPLEGIVSLPVTFCSCVEGSCFRPAGHQTGIPTVGMAVGILLTTL----- 796
+ I I D G P L +L + C C + + + G++ G L+ L
Sbjct: 560 LPIFIVDSGSPSLSSTNTLTIRVCDCDADGVAQTCNAEAYVLPAGLSTGALIAILACVLT 619
Query: 797 LVIGIILAVVFIRIKKD 813
L++ I+L V R KK+
Sbjct: 620 LLVLILLIVTMRRRKKE 636
Score = 160 bits (404), Expect = 6e-39
Identities = 143/454 (31%), Positives = 211/454 (46%), Gaps = 47/454 (10%)
Query: 57 AVTFELTGE-TDNIFVI-EREGLLYYNRALDRETRSTHNLQVAALDA-NGIIVEGPVPIT 113
++ + L+GE +IF+I E G ++ + LDRE ++ + L+ ALD VE
Sbjct: 81 SIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFV 140
Query: 114 IKVKDINDNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPN-GQLYYQIVIQLP 172
IK++DINDN P FL Y V + S G + V ATD DDP N ++ Y I+ P
Sbjct: 141 IKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQP 200
Query: 173 MINNVMYFQINNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDI 232
YF + KTG I + ++ Y LVI KDM GQ+ S TTSV +
Sbjct: 201 ------YFSVEPKTGVI---KTALPNMDREAKDQYLLVIQAKDMVGQN-GGLSGTTSVTV 250
Query: 233 IVTENIWKAPKPVEMVENSTDPHPIKITQVRWN------DPGA----QYSLVDKEKLPRF 282
+T+ P+ P + + V D GA +Y +VD + L F
Sbjct: 251 TLTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKAADADIGANAEMEYKIVDGDGLGIF 310
Query: 283 PFSID---QEGDIYVTQPLDREEKDAYVFYAVAKDEYGK-------PLSYPLEIHVKVKD 332
S+D QEG I + + LD E K +Y A ++ P S + + V+D
Sbjct: 311 KISVDKETQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVED 370
Query: 333 INDNPPTCPSPVTVFEVQENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDG 392
+ D PP SP+ EV E ++GN IGT+ AHD D ++NS + Y I T ++
Sbjct: 371 V-DEPPVFSSPLYPMEVSEATQVGNIIGTVAAHDPD---SSNSPVRYSIDRNT---DLER 423
Query: 393 LFLIQTYAGMLQLAKQSLKKQDTPQYNLTIEVSDKDFKTLC---FVQINVIDINDQIPIF 449
F I +G++ AK SL ++ +N+T+ + + +V I ++DIND P F
Sbjct: 424 YFNIDANSGVITTAK-SLDRETNAIHNITVLAMESQNPSQVGRGYVAITILDINDNAPEF 482
Query: 450 EKSDYGNLTLAEDTNIGSTILTIQATDADEPFTG 483
DY T+ E+ G I I A D DEP G
Sbjct: 483 -AMDY-ETTVCENAQPGQVIQKISAVDKDEPSNG 514
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.136 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,267,302
Number of Sequences: 37866
Number of extensions: 1511934
Number of successful extensions: 8087
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 185
Number of HSP's successfully gapped in prelim test: 21
Number of HSP's that attempted gapping in prelim test: 2958
Number of HSP's gapped (non-prelim): 1140
length of query: 832
length of database: 18,247,518
effective HSP length: 111
effective length of query: 721
effective length of database: 14,044,392
effective search space: 10126006632
effective search space used: 10126006632
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.