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Search of human proteins with 22035677
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22035677 AT rich interactive domain 4B isoform 1 [Homo
sapiens]
(1312 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22035677 AT rich interactive domain 4B isoform 1 [Homo sapiens] 2606 0.0
gi|22035679 AT rich interactive domain 4B isoform 2 [Homo sapiens] 2239 0.0
gi|115334677 retinoblastoma-binding protein 1 isoform I [Homo sa... 925 0.0
gi|115334679 retinoblastoma-binding protein 1 isoform III [Homo ... 854 0.0
gi|115334673 retinoblastoma-binding protein 1 isoform II [Homo s... 801 0.0
gi|74136549 AT rich interactive domain 5B (MRF1-like) [Homo sapi... 93 2e-18
gi|62865637 AT rich interactive domain 3C (BRIGHT- like) [Homo s... 86 2e-16
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 84 7e-16
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 84 7e-16
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 84 7e-16
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 83 2e-15
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 80 2e-14
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 78 5e-14
gi|47078224 AT rich interactive domain 5A [Homo sapiens] 77 1e-13
gi|5453638 AT rich interactive domain 3B [Homo sapiens] 76 2e-13
gi|87299628 biorientation of chromosomes in cell division 1-like... 75 3e-13
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 75 4e-13
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 75 4e-13
gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1... 75 4e-13
gi|46852388 cell-cycle and apoptosis regulatory protein 1 [Homo ... 75 5e-13
gi|4885193 AT rich interactive domain 3A (BRIGHT- like) protein ... 72 3e-12
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 70 1e-11
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] 70 1e-11
gi|55956788 nucleolin [Homo sapiens] 69 3e-11
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens] 69 3e-11
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 67 1e-10
gi|104526627 triadin [Homo sapiens] 67 1e-10
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 66 3e-10
gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sap... 66 3e-10
gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sap... 66 3e-10
>gi|22035677 AT rich interactive domain 4B isoform 1 [Homo sapiens]
Length = 1312
Score = 2606 bits (6755), Expect = 0.0
Identities = 1312/1312 (100%), Positives = 1312/1312 (100%)
Query: 1 MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPL 60
MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPL
Sbjct: 1 MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPL 60
Query: 61 KVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETL 120
KVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETL
Sbjct: 61 KVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETL 120
Query: 121 DQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDEDEDDRKQIDELLGKVVCVD 180
DQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDEDEDDRKQIDELLGKVVCVD
Sbjct: 121 DQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDEDEDDRKQIDELLGKVVCVD 180
Query: 181 YISLDKKKALWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTAPK 240
YISLDKKKALWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTAPK
Sbjct: 181 YISLDKKKALWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTAPK 240
Query: 241 PDAVLKQAFEQALEFHKSRTIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEE 300
PDAVLKQAFEQALEFHKSRTIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEE
Sbjct: 241 PDAVLKQAFEQALEFHKSRTIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEE 300
Query: 301 EIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGA 360
EIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGA
Sbjct: 301 EIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGA 360
Query: 361 VWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQMALPEKVVNKQCKEC 420
VWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQMALPEKVVNKQCKEC
Sbjct: 361 VWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQMALPEKVVNKQCKEC 420
Query: 421 ENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLESIP 480
ENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLESIP
Sbjct: 421 ENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLESIP 480
Query: 481 THSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGDETNKEEDEDDE 540
THSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGDETNKEEDEDDE
Sbjct: 481 THSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGDETNKEEDEDDE 540
Query: 541 EAEEEEEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGG 600
EAEEEEEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGG
Sbjct: 541 EAEEEEEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGG 600
Query: 601 EVLYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNC 660
EVLYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNC
Sbjct: 601 EVLYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNC 660
Query: 661 KLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQE 720
KLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQE
Sbjct: 661 KLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQE 720
Query: 721 DERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPE 780
DERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPE
Sbjct: 721 DERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPE 780
Query: 781 RLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPG 840
RLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPG
Sbjct: 781 RLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPG 840
Query: 841 KKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSE 900
KKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSE
Sbjct: 841 KKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSE 900
Query: 901 VAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAP 960
VAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAP
Sbjct: 901 VAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAP 960
Query: 961 EEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVL 1020
EEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVL
Sbjct: 961 EEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVL 1020
Query: 1021 NTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQD 1080
NTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQD
Sbjct: 1021 NTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQD 1080
Query: 1081 LQSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATV 1140
LQSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATV
Sbjct: 1081 LQSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATV 1140
Query: 1141 VNNKKKGKGTNSSDSEELSAGESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDK 1200
VNNKKKGKGTNSSDSEELSAGESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDK
Sbjct: 1141 VNNKKKGKGTNSSDSEELSAGESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDK 1200
Query: 1201 DPDLKEPSNRLPKVYKWSFQMSDLENMTSAERITILQEKLQEIRKHYLSLKSEVASIDRR 1260
DPDLKEPSNRLPKVYKWSFQMSDLENMTSAERITILQEKLQEIRKHYLSLKSEVASIDRR
Sbjct: 1201 DPDLKEPSNRLPKVYKWSFQMSDLENMTSAERITILQEKLQEIRKHYLSLKSEVASIDRR 1260
Query: 1261 RKRLKKKERESAATSSSSSSPSSSSITAAVMLTLAEPSMSSASQNGMSVECR 1312
RKRLKKKERESAATSSSSSSPSSSSITAAVMLTLAEPSMSSASQNGMSVECR
Sbjct: 1261 RKRLKKKERESAATSSSSSSPSSSSITAAVMLTLAEPSMSSASQNGMSVECR 1312
>gi|22035679 AT rich interactive domain 4B isoform 2 [Homo sapiens]
Length = 1226
Score = 2239 bits (5803), Expect = 0.0
Identities = 1166/1313 (88%), Positives = 1187/1313 (90%), Gaps = 88/1313 (6%)
Query: 1 MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPL 60
MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPL
Sbjct: 1 MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPL 60
Query: 61 KVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETL 120
KVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETL
Sbjct: 61 KVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETL 120
Query: 121 DQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDEDEDDRKQIDELLGKVVCVD 180
DQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDEDEDDRKQIDELLGKVVCVD
Sbjct: 121 DQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDEDEDDRKQIDELLGKVVCVD 180
Query: 181 YISLDKKKALWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTAPK 240
YISLDKKKALWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTAPK
Sbjct: 181 YISLDKKKALWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTAPK 240
Query: 241 PDAVLKQAFEQALEFHKSRTIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEE 300
PDAVLKQAFEQALEFHKSRTIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEE
Sbjct: 241 PDAVLKQAFEQALEFHKSRTIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEE 300
Query: 301 EIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGA 360
EIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGA
Sbjct: 301 EIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGA 360
Query: 361 VWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQMALPEKVVNKQCKEC 420
VWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQMALPEKVVNKQCKEC
Sbjct: 361 VWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQMALPEKVVNKQCKEC 420
Query: 421 ENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLESIP 480
ENVKEIKVKEENETEIKEIK +E + NI P E P
Sbjct: 421 ENVKEIKVKEENETEIKEIK------------------MEEERNIIPR--------EEKP 454
Query: 481 THSDQEKEVNIKKP-EDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGDETNKEEDEDD 539
+ E++ NIK +NL + +I +++EK E N ++ ED+
Sbjct: 455 IEDEIERKENIKPSLGSKKNLLE------------SIPTHSDQEK-----EVNIKKPEDN 497
Query: 540 EEAEEEEEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEG 599
E + D+DDD +E +KV+ + K+
Sbjct: 498 ENLD----------DKDDDTTRVDESLN-----IKVEAEEEKAKSG-------------- 528
Query: 600 GEVLYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKN 659
YDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKN
Sbjct: 529 ---------------YDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKN 573
Query: 660 CKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQ 719
CKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQ
Sbjct: 574 CKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQ 633
Query: 720 EDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSP 779
EDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSP
Sbjct: 634 EDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSP 693
Query: 780 ERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSP 839
ERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSP
Sbjct: 694 ERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSP 753
Query: 840 GKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFS 899
GKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFS
Sbjct: 754 GKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFS 813
Query: 900 EVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPA 959
EVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPA
Sbjct: 814 EVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPA 873
Query: 960 PEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSV 1019
PEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSV
Sbjct: 874 PEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSV 933
Query: 1020 LNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQ 1079
LNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQ
Sbjct: 934 LNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQ 993
Query: 1080 DLQSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRSHKAT 1139
DLQSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRSHKAT
Sbjct: 994 DLQSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRSHKAT 1053
Query: 1140 VVNNKKKGKGTNSSDSEELSAGESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGD 1199
VVNNKKKGKGTNSSDSEELSAGESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGD
Sbjct: 1054 VVNNKKKGKGTNSSDSEELSAGESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGD 1113
Query: 1200 KDPDLKEPSNRLPKVYKWSFQMSDLENMTSAERITILQEKLQEIRKHYLSLKSEVASIDR 1259
KDPDLKEPSNRLPKVYKWSFQMSDLENMTSAERITILQEKLQEIRKHYLSLKSEVASIDR
Sbjct: 1114 KDPDLKEPSNRLPKVYKWSFQMSDLENMTSAERITILQEKLQEIRKHYLSLKSEVASIDR 1173
Query: 1260 RRKRLKKKERESAATSSSSSSPSSSSITAAVMLTLAEPSMSSASQNGMSVECR 1312
RRKRLKKKERESAATSSSSSSPSSSSITAAVMLTLAEPSMSSASQNGMSVECR
Sbjct: 1174 RRKRLKKKERESAATSSSSSSPSSSSITAAVMLTLAEPSMSSASQNGMSVECR 1226
>gi|115334677 retinoblastoma-binding protein 1 isoform I [Homo
sapiens]
Length = 1257
Score = 925 bits (2391), Expect = 0.0
Identities = 597/1346 (44%), Positives = 798/1346 (59%), Gaps = 123/1346 (9%)
Query: 1 MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPL 60
MKA DEP YLTVGTDVSAKYRGAFCEAKIKT KRLVKVKV + D++T VQDD +KGPL
Sbjct: 1 MKAADEPAYLTVGTDVSAKYRGAFCEAKIKTVKRLVKVKVLLKQDNTTQLVQDDQVKGPL 60
Query: 61 KVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETL 120
+VGAIVE + DG++QEA+I+KLTDASWYTVVFDDGDE+TLRR+SLCLKGERHFAESETL
Sbjct: 61 RVGAIVETRTSDGSFQEAIISKLTDASWYTVVFDDGDERTLRRTSLCLKGERHFAESETL 120
Query: 121 DQLPLTNPEHFGTPVIGKKTNRGRRSNHIP---EEESSSSSSDEDEDDRKQIDELLGKVV 177
DQLPLTNPEHFGTPVI KKTNRGRRS+ +P +E+ SS +EDED R+ DELLGKVV
Sbjct: 121 DQLPLTNPEHFGTPVIAKKTNRGRRSS-LPVTEDEKEEESSEEEDEDKRRLNDELLGKVV 179
Query: 178 CVDYISLDKKKALWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDT 237
V + ++ W+PALV+ P C+D+I VKKD LVRSF D KF S+ RKD+ E+
Sbjct: 180 SVVSAT---ERTEWYPALVISPSCNDDITVKKDQCLVRSFIDSKFYSIARKDIKEVDILN 236
Query: 238 APKPDAVLKQAFEQALEFHKSRTIPANWKTELKEDSSSSEAEEEE---EEEDDEKEKEDN 294
P+ + K ++A F K+R +P NWK ++ E SS +++E+ EE D+EKEKE
Sbjct: 237 LPESELSTKPGLQKASIFLKTRVVPDNWKMDISEILESSSSDDEDGPAEENDEEKEKEAK 296
Query: 295 SSEEE-EEIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGF 353
+EEE E E PEER+NFLQQLYKFMEDRGTPINK PVLGY++LNLFKLFRLV+ GG
Sbjct: 297 KTEEEVPEEELDPEERDNFLQQLYKFMEDRGTPINKPPVLGYKDLNLFKLFRLVYHQGGC 356
Query: 354 DNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQ-MALPEKV 412
DNI+SGAVWKQ+Y DLGIP+LNSAA YNVK AY+KYLYGFEEYCRSANI+F+ + E
Sbjct: 357 DNIDSGAVWKQIYMDLGIPILNSAASYNVKTAYRKYLYGFEEYCRSANIQFRTVHHHEPK 416
Query: 413 VNKQCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSK 472
V ++ K+ E E +K + E + E+K E E NI E +EIE +K G +
Sbjct: 417 VKEEKKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESE-REEIE----LKSPRGRR 471
Query: 473 K--NLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGDE 530
+ + SI ++EK + K D EN D DD T + + + + + +
Sbjct: 472 RIARDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKK 531
Query: 531 TNKEEDEDDEEAEEEEEEEEEEEDE---DDDDNNEEEEFECYPPGMKVQVRYGRGKNQKM 587
K+ED D + EEEE+ +E EE E D + +EE+ E G KV+V+YGRGK QK+
Sbjct: 532 IKKQEDSDKDSDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVKYGRGKTQKI 591
Query: 588 YEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDK 647
YEASIK ++++ GEVLYLVHY GWNVRYDEW+KAD+I+ P DK PK K +KK KNK D
Sbjct: 592 YEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDS 651
Query: 648 EKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGL 707
E KDEK + K +R +PP ++ S M L T N
Sbjct: 652 E--KDEKRDEERQKSKR-GRPPLKSTLSSNMPYGLSKT------------------ANSE 690
Query: 708 QASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHA 767
S+S + DSE ED E++ I+ + +++L E N L EEN
Sbjct: 691 GKSDSCSSDSETED----------ALEKNLINEELSLKDELEKNENLNDDKLDEENP--- 737
Query: 768 DLVISKPVSKSPERLR-KDIEVLSEDTDYEEDEV------TKKRKDVKKDTTDKSSKPQI 820
IS + K +R + + +E L + E V +K ++VKK+ +KS K +
Sbjct: 738 --KISAHILKENDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTEEVKKE-AEKSPKGKG 794
Query: 821 KRGKRRYCNTEECLKTGSPGKKEE------KAKNKESLCMENSSNSSSDEDEEETKAKMT 874
+R K + + E +K S G+ E +A + E ++N + SS+ EDE + K
Sbjct: 795 RRSKTKDLSL-EIIKISSFGQNEAGSEPHIEAHSLELSSLDNKNFSSATEDEIDQCVKEK 853
Query: 875 PTK-KYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSD--ERLQNSRAKDRKDVWSSI 931
K K G K +R + V+++R S+ + L + +R++
Sbjct: 854 KLKRKILGQSSPEKKIRIENGMEMTNTVSQERTSDCIGSEGMKNLNFEQHFERENEGMPS 913
Query: 932 QGQWPKKTLKELFSDS-DTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPV 990
+ +++L S+ D+ A + P E+ E+++ + E V+L+
Sbjct: 914 LIAESNQCIQQLTSERFDSPAEETVNIPLKED---EDAMPLIGPETLVCHEVDLDDLD-- 968
Query: 991 NVDSKPIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEP 1050
D IE+ VE SS SNS+++ PP P Q + +V+ P
Sbjct: 969 EKDKTSIEDVAVE---------SSESNSLVSIPPALPPV-----------VQHNFSVASP 1008
Query: 1051 LAPNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSN--QPEPEH 1108
L +Q+E RS+KSE+D TIEVDS+A E Q+ E S GF+ +V+S + + E E
Sbjct: 1009 LTLSQDESRSVKSESDITIEVDSIAEESQEGLCE-RESANGFETNVASGTCSIIVQERES 1067
Query: 1109 PEKACTGQKRVKDAQGGGSSSKKQKRSHKAT--VVNNKKKGKGTNSSDSEELSAGESITK 1166
EK GQKR D G +KKQKR+ K T N+K G G SSDSE+L ++ +K
Sbjct: 1068 REK---GQKRPSDG-NSGLMAKKQKRTPKRTSAAAKNEKNGTG-QSSDSEDLPVLDNSSK 1122
Query: 1167 SQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDKDPDLKEPSNRLPKVYKWSFQMSDLEN 1226
PVK ++ +SPAR SP K+G+KD ++ N P+ YKWSFQ+++L+N
Sbjct: 1123 CTPVKHLNVSKPQKLARSPARI-SPHI--KDGEKDKHREKHPNSSPRTYKWSFQLNELDN 1179
Query: 1227 MTSAERITILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSSSSSPSSSSI 1286
M S ERI+ LQEKLQEIRK+Y+SLKSEVA+IDRRRKRLKKK+RE + +S SS SS
Sbjct: 1180 MNSTERISFLQEKLQEIRKYYMSLKSEVATIDRRRKRLKKKDREVSHAGASMSSASSD-- 1237
Query: 1287 TAAVMLTLAEPSMSSASQNGMSVECR 1312
T PS SS QN ++VECR
Sbjct: 1238 ------TGMSPSSSSPPQNVLAVECR 1257
>gi|115334679 retinoblastoma-binding protein 1 isoform III [Homo
sapiens]
Length = 1188
Score = 854 bits (2206), Expect = 0.0
Identities = 571/1344 (42%), Positives = 757/1344 (56%), Gaps = 188/1344 (13%)
Query: 1 MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPL 60
MKA DEP YLTVGTDVSAKYRGAFCEAKIKT KRLVKVKV + D++T VQDD +KGPL
Sbjct: 1 MKAADEPAYLTVGTDVSAKYRGAFCEAKIKTVKRLVKVKVLLKQDNTTQLVQDDQVKGPL 60
Query: 61 KVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETL 120
+VGAIVE + DG++QEA+I+KLTDASWYTVVFDDGDE+TLRR+SLCLKGERHFAESETL
Sbjct: 61 RVGAIVETRTSDGSFQEAIISKLTDASWYTVVFDDGDERTLRRTSLCLKGERHFAESETL 120
Query: 121 DQLPLTNPEHFGTPVIGKKTNRGRRSNHIP---EEESSSSSSDEDEDDRKQIDELLGKVV 177
DQLPLTNPEHFGTPVI KKTNRGRRS+ +P +E+ SS +EDED R+ DELLGKVV
Sbjct: 121 DQLPLTNPEHFGTPVIAKKTNRGRRSS-LPVTEDEKEEESSEEEDEDKRRLNDELLGKVV 179
Query: 178 CVDYISLDKKKALWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDT 237
V + ++ W+PALV+ P C+D+I VKKD LVRSF D KF S+ RKD+ E+
Sbjct: 180 SVVSAT---ERTEWYPALVISPSCNDDITVKKDQCLVRSFIDSKFYSIARKDIKEVDILN 236
Query: 238 APKPDAVLKQAFEQALEFHKSRTIPANWKTELKEDSSSSEAEEEE---EEEDDEKEKEDN 294
P+ + K ++A F K+R +P NWK ++ E SS +++E+ EE D+EKEKE
Sbjct: 237 LPESELSTKPGLQKASIFLKTRVVPDNWKMDISEILESSSSDDEDGPAEENDEEKEKEAK 296
Query: 295 SSEEE-EEIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGF 353
+EEE E E PEER+NFLQQLYKFMEDRGTPINK PVLGY++LNLFKLFRLV+ GG
Sbjct: 297 KTEEEVPEEELDPEERDNFLQQLYKFMEDRGTPINKPPVLGYKDLNLFKLFRLVYHQGGC 356
Query: 354 DNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQMALP-EKV 412
DNI+SGAVWKQ+Y DLGIP+LNSAA YNVK AY+KYLYGFEEYCRSANI+F+ E
Sbjct: 357 DNIDSGAVWKQIYMDLGIPILNSAASYNVKTAYRKYLYGFEEYCRSANIQFRTVHHHEPK 416
Query: 413 VNKQCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSK 472
V ++ K+ E E +K + E + E+K E E NI E E EIE +K G +
Sbjct: 417 VKEEKKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESERE-EIE----LKSPRGRR 471
Query: 473 KNL--LESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGDE 530
+ + SI ++EK + K D EN D DD T + + + + + +
Sbjct: 472 RIARDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKK 531
Query: 531 TNKEEDEDDEEAEEEEEEEEEEEDEDDDDNNEEEEFECYPP---GMKVQVRYGRGKNQKM 587
K+ED D + EEEE+ +E EE E D+ EE+ E P G KV+V+YGRGK QK+
Sbjct: 532 IKKQEDSDKDSDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVKYGRGKTQKI 591
Query: 588 YEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDK 647
YEASIK ++++ GEVLYLVHY GWNVRYDEW+KAD+I+ P DK PK K +KK KNK D
Sbjct: 592 YEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDS 651
Query: 648 EKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGL 707
EKD EK + K +R +PP ++ S M L T N
Sbjct: 652 EKD--EKRDEERQKSKR-GRPPLKSTLSSNMPYGLSKT------------------ANSE 690
Query: 708 QASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHA 767
S+S + DSE ED E++ I+ + +++L E N L EEN
Sbjct: 691 GKSDSCSSDSETED----------ALEKNLINEELSLKDELEKNENLNDDKLDEENPK-- 738
Query: 768 DLVISKPVSKSPERLR-KDIEVLSEDTDYEEDEVT------KKRKDVKKDTTDKSSKPQI 820
IS + K +R + + +E L + E V +K ++VKK+ +KS K +
Sbjct: 739 ---ISAHILKENDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTEEVKKEA-EKSPKGKG 794
Query: 821 KRGKRRYCNTEECLKTGSPGKKEE------KAKNKESLCMENSSNSSSDEDEEETKAKMT 874
+R K + + E +K S G+ E +A + E ++N + SS+ EDE + K
Sbjct: 795 RRSKTKDLSLE-IIKISSFGQNEAGSEPHIEAHSLELSSLDNKNFSSATEDEIDQCVKEK 853
Query: 875 PTK-KYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSD--ERLQNSRAKDRKDVWSSI 931
K K G K +R + V+++R S+ + L + +R++
Sbjct: 854 KLKRKILGQSSPEKKIRIENGMEMTNTVSQERTSDCIGSEGMKNLNFEQHFERENEGMPS 913
Query: 932 QGQWPKKTLKELFSDS-DTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPV 990
+ +++L S+ D+ A + P E+ E+++ + E V+L+
Sbjct: 914 LIAESNQCIQQLTSERFDSPAEETVNIPLKED---EDAMPLIGPETLVCHEVDLDDLD-- 968
Query: 991 NVDSKPIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEP 1050
D IE+ VE SS SNS+++ PP P Q + +V+ P
Sbjct: 969 EKDKTSIEDVAVE---------SSESNSLVSIPPALPPVV-----------QHNFSVASP 1008
Query: 1051 LAPNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSN--QPEPEH 1108
L +Q+E RS+KSE+D TIEVDS+A E Q+ E S+ GF+ +V+S + + E E
Sbjct: 1009 LTLSQDESRSVKSESDITIEVDSIAEESQEGLCERESAN-GFETNVASGTCSIIVQERES 1067
Query: 1109 PEKACTGQKRVKDAQGGGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESITKSQ 1168
EK GQKR D G +KKQK
Sbjct: 1068 REK---GQKRPSDGNSG-LMAKKQK----------------------------------- 1088
Query: 1169 PVKSVSTGMKSHSTKSPARTQSPGKCGKNGDKDPDLKEPSNRLPKVYKWSFQMSDLENMT 1228
++P RT + K KNG +L+NM
Sbjct: 1089 --------------RTPKRTSAAAKNEKNGT----------------------DELDNMN 1112
Query: 1229 SAERITILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSSSSSPSSSSITA 1288
S ERI+ LQEKLQEIRK+Y+SLKSEVA+IDRRRKRLKKK+RE + +S SS SS
Sbjct: 1113 STERISFLQEKLQEIRKYYMSLKSEVATIDRRRKRLKKKDREVSHAGASMSSASSD---- 1168
Query: 1289 AVMLTLAEPSMSSASQNGMSVECR 1312
T PS SS QN ++VECR
Sbjct: 1169 ----TGMSPSSSSPPQNVLAVECR 1188
>gi|115334673 retinoblastoma-binding protein 1 isoform II [Homo
sapiens]
Length = 1203
Score = 801 bits (2068), Expect = 0.0
Identities = 547/1346 (40%), Positives = 744/1346 (55%), Gaps = 177/1346 (13%)
Query: 1 MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPL 60
MKA DEP YLTVGTDVSAKYRGAFCEAKIKT KRLVKVKV + D++T VQDD +KGPL
Sbjct: 1 MKAADEPAYLTVGTDVSAKYRGAFCEAKIKTVKRLVKVKVLLKQDNTTQLVQDDQVKGPL 60
Query: 61 KVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETL 120
+VGAIVE + DG++QEA+I+KLTDASWYTVVFDDGDE+TLRR+SLCLKGERHFAESETL
Sbjct: 61 RVGAIVETRTSDGSFQEAIISKLTDASWYTVVFDDGDERTLRRTSLCLKGERHFAESETL 120
Query: 121 DQLPLTNPEHFGTPVIGKKTNRGRRSNHIP---EEESSSSSSDEDEDDRKQIDELLGKVV 177
DQLPLTNPEHFGTPVI KKTNRGRRS+ +P +E+ SS +EDED R+ DELLGKVV
Sbjct: 121 DQLPLTNPEHFGTPVIAKKTNRGRRSS-LPVTEDEKEEESSEEEDEDKRRLNDELLGKVV 179
Query: 178 CVDYISLDKKKALWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDT 237
V + ++ W+PALV+ P C+D+I VKKD LVRSF D KF S+ RKD+ E+
Sbjct: 180 SVVSAT---ERTEWYPALVISPSCNDDITVKKDQCLVRSFIDSKFYSIARKDIKEVDILN 236
Query: 238 APKPDAVLKQAFEQALEFHKSRTIPANWKTELKEDSSSSEAEEEE---EEEDDEKEKEDN 294
P+ + K ++A F K+R +P NWK ++ E SS +++E+ EE D+EKEKE
Sbjct: 237 LPESELSTKPGLQKASIFLKTRVVPDNWKMDISEILESSSSDDEDGPAEENDEEKEKEAK 296
Query: 295 SSEEE-EEIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGF 353
+EEE E E PEER+NFLQQLYKFMEDRGTPINK PVLGY++LNLFKLFRLV+ GG
Sbjct: 297 KTEEEVPEEELDPEERDNFLQQLYKFMEDRGTPINKPPVLGYKDLNLFKLFRLVYHQGGC 356
Query: 354 DNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQ-MALPEKV 412
DNI+SGAVWKQ+Y DLGIP+LNSAA YNVK AY+KYLYGFEEYCRSANI+F+ + E
Sbjct: 357 DNIDSGAVWKQIYMDLGIPILNSAASYNVKTAYRKYLYGFEEYCRSANIQFRTVHHHEPK 416
Query: 413 VNKQCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSK 472
V ++ K+ E E +K + E + E+K E E NI E +EIE +K G +
Sbjct: 417 VKEEKKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESE-REEIE----LKSPRGRR 471
Query: 473 K--NLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGDE 530
+ + SI ++EK + K D EN D DD T + + + + + +
Sbjct: 472 RIARDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKK 531
Query: 531 TNKEEDEDDEEAEEEEEEEEEEEDE---DDDDNNEEEEFECYPPGMKVQVRYGRGKNQKM 587
K+ED D + EEEE+ +E EE E D + +EE+ E G KV+V+YGRGK QK+
Sbjct: 532 IKKQEDSDKDSDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVKYGRGKTQKI 591
Query: 588 YEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDK 647
YEASIK ++++ GEVLYLVHY GWNVRYDEW+KAD+I+ P DK PK K +KK KNK D
Sbjct: 592 YEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDS 651
Query: 648 EKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGL 707
E KDEK + K +R +PP ++ S M L T N
Sbjct: 652 E--KDEKRDEERQKSKR-GRPPLKSTLSSNMPYGLSKT------------------ANSE 690
Query: 708 QASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHA 767
S+S + DSE ED E++ I+ + +++L E N L EEN
Sbjct: 691 GKSDSCSSDSETED----------ALEKNLINEELSLKDELEKNENLNDDKLDEENP--- 737
Query: 768 DLVISKPVSKSPERLR-KDIEVLSEDTDYEEDEV------TKKRKDVKKDTTDKSSKPQI 820
IS + K +R + + +E L + E V +K ++VKK+ +KS K +
Sbjct: 738 --KISAHILKENDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTEEVKKE-AEKSPKGKG 794
Query: 821 KRGKRRYCNTEECLKTGSPGKKEE------KAKNKESLCMENSSNSSSDEDEEETKAKMT 874
+R K + + E +K S G+ E +A + E ++N + SS+ EDE + K
Sbjct: 795 RRSKTKDLSL-EIIKISSFGQNEAGSEPHIEAHSLELSSLDNKNFSSATEDEIDQCVKEK 853
Query: 875 PTK-KYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSD--ERLQNSRAKDRKDVWSSI 931
K K G K +R + V+++R S+ + L + +R++
Sbjct: 854 KLKRKILGQSSPEKKIRIENGMEMTNTVSQERTSDCIGSEGMKNLNFEQHFERENEGMPS 913
Query: 932 QGQWPKKTLKELFSDS-DTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPV 990
+ +++L S+ D+ A + P E+ E+++ + E V+L+
Sbjct: 914 LIAESNQCIQQLTSERFDSPAEETVNIPLKED---EDAMPLIGPETLVCHEVDLDDLD-- 968
Query: 991 NVDSKPIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEP 1050
D IE+ VE SS SNS+++ PP P Q + +V+ P
Sbjct: 969 EKDKTSIEDVAVE---------SSESNSLVSIPPALPPV-----------VQHNFSVASP 1008
Query: 1051 LAPNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSN--QPEPEH 1108
L +Q+E RS+KSE+D TIEVDS+A E Q+ E S GF+ +V+S + + E E
Sbjct: 1009 LTLSQDESRSVKSESDITIEVDSIAEESQEGLCE-RESANGFETNVASGTCSIIVQERES 1067
Query: 1109 PEKACTGQKRVKDAQGGGSSSKKQKRSHKAT--VVNNKKKGKGTNSSDSEELSAGESITK 1166
EK GQKR D G +KKQKR+ K T N+K G G SSDSE+L ++ +
Sbjct: 1068 REK---GQKRPSDG-NSGLMAKKQKRTPKRTSAAAKNEKNGTG-QSSDSEDLPVLDNSNE 1122
Query: 1167 SQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDKDPDLKEPSNRLPKVYKWSFQMSDLEN 1226
+ S ++ L+E + K Y
Sbjct: 1123 LDNMNST-------------------------ERISFLQEKLQEIRKYY----------- 1146
Query: 1227 MTSAERITILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSSSSSPSSSSI 1286
M+ + + + + ++K K+RE + +S SS SS
Sbjct: 1147 MSLKSEVATIDRRRKRLKK---------------------KDREVSHAGASMSSASSD-- 1183
Query: 1287 TAAVMLTLAEPSMSSASQNGMSVECR 1312
T PS SS QN ++VECR
Sbjct: 1184 ------TGMSPSSSSPPQNVLAVECR 1203
>gi|74136549 AT rich interactive domain 5B (MRF1-like) [Homo
sapiens]
Length = 1188
Score = 92.8 bits (229), Expect = 2e-18
Identities = 126/599 (21%), Positives = 247/599 (41%), Gaps = 50/599 (8%)
Query: 295 SSEEEEEI---EPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLG 351
S+EE+ ++ E + + FL LYK+M++R TPI + P LG++ +NL+ +F+ KLG
Sbjct: 304 SNEEKPKVAIGEECRADEQAFLVALYKYMKERKTPIERIPYLGFKQINLWTMFQAAQKLG 363
Query: 352 GFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQMALPEK 411
G++ I + WK +Y +LG +++A + Y++ + +E + + + + +
Sbjct: 364 GYETITARRQWKHIYDELGGNPGSTSAATCTRRHYERLILPYERFIKGEEDKPLPPIKPR 423
Query: 412 VVNKQCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGS 471
+E EN ++ + + EI + K E+E P++ + E E+++ +L S
Sbjct: 424 KQENSSQENENKTKVSGTKRIKHEIPKSKKEKENAPKPQDAAEVSSEQEKEQE---TLIS 480
Query: 472 KKNLLESIPTHSDQEKEVN-----IKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAK 526
+K++ E +P +D +K++ KP + +KD++T + S + EA E+
Sbjct: 481 QKSIPEPLPA-ADMKKKIEGYQEFSAKPLASRVDPEKDNETDQGSNSEKVAEEAGEKGPT 539
Query: 527 SGDETNKEEDEDDEEAEEEEEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQK 586
+ E D ++ D+ +E + C+ + + + +
Sbjct: 540 PPLPSAPLAPEKDSALVPGASKQPLTSPSALVDSKQESKLCCFTESPESEPQEASFPSFP 599
Query: 587 MYEASI-KDSDVEGGEVLYLVHY-CGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNK 644
+ + ++ E ++ + Y V+ D+ D + A K PK+ +
Sbjct: 600 TTQPPLANQNETEDDKLPAMADYIANCTVKVDQLGSDD--IHNALKQTPKV----LVVQS 653
Query: 645 LDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSI- 703
D KDKD P N P + +P ++S L AK + + ++S
Sbjct: 654 FDMFKDKD-LTGPMNENHGLNYTPLLYSRGNPGIMSPL----AKKKLLSQVSGASLSSSY 708
Query: 704 -LNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEE 762
S + ++D + ++G+ DH+ +R +I + S EE
Sbjct: 709 PYGSPPPLISKKKLIARDDLCSSLSQTHHGQ---STDHMAVSRPSVIQHVQSFRSKPSEE 765
Query: 763 NKVHADLVISKPVSKS-PERLR---------KDIEVLSEDTDYEEDEVTKKR----KDVK 808
K D+ + +S+S P R D VL ++ +D++ +KR +
Sbjct: 766 RKTINDIFKHEKLSRSDPHRCSFSKHHLNPLADSYVLKQEIQEGKDKLLEKRALPHSHMP 825
Query: 809 KDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEE 867
D S P + Y +TE L K + +ES ENSS S E+
Sbjct: 826 SFLADFYSSPHL---HSLYRHTEHHLHNEQTSKYPSRDMYRES---ENSSFPSHRHQEK 878
>gi|62865637 AT rich interactive domain 3C (BRIGHT- like) [Homo
sapiens]
Length = 412
Score = 85.9 bits (211), Expect = 2e-16
Identities = 50/152 (32%), Positives = 79/152 (51%), Gaps = 35/152 (23%)
Query: 278 AEEEEEEEDDEKEKEDNSSEEE--EEIEP---------------FPEE------------ 308
AEEEE+ E+DE+++E+ +EEE EE P P E
Sbjct: 50 AEEEEDAEEDEEKREEAGAEEEAAEESRPGAQGPSSPSSQPPGLHPHEWTYEEQFKQLYE 109
Query: 309 ------RENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVW 362
R+ FL L+ FM+ RGTP+N+ P++ + L+L+ LFRLV GG + + VW
Sbjct: 110 LDADPKRKEFLDDLFSFMQKRGTPVNRVPIMAKQVLDLYALFRLVTAKGGLVEVINRKVW 169
Query: 363 KQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFE 394
++V + L +P ++A + ++ Y KYLY +E
Sbjct: 170 REVTRGLSLPTTITSAAFTLRTQYMKYLYPYE 201
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 84.3 bits (207), Expect = 7e-16
Identities = 167/734 (22%), Positives = 293/734 (39%), Gaps = 123/734 (16%)
Query: 401 NIEFQMALPEKV--VNKQCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDE 458
N+E + EK + K K+ ++ KE V +E + + K+++E REEK I+D
Sbjct: 689 NMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEK-IKDL 747
Query: 459 IERKENIKPSLGSKKNLL------ESIPTHSDQEKEVNIKKPEDN-ENLDDKDDDTTRVD 511
E +ENI S+ L ESI H EKE++I+K E + + +K + +++
Sbjct: 748 KEERENIPTDKDSEFTSLGMSAIEESIGLHL-VEKEIDIEKQEKHIKESKEKPEKRSQIK 806
Query: 512 ESLNIKVEAEEEKAKSGDETNKEEDEDDEEAEEEEEEEEEEEDEDDDDNNEEEEFECYPP 571
E + E+ + K+ ++ K + E E ++ + E ++ ++ D +C+
Sbjct: 807 EK-----DIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKE 861
Query: 572 GMKVQVRYGRGKNQKMYEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIKADKIVRPADKN 631
G K KN A+IK +D D +K+ R DK
Sbjct: 862 GEK-------SKNT----AAIKKTD-------------------DREKSREKMDRKHDKE 891
Query: 632 VP-KIKH-----RKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLT 685
P K +H K + K +K+ D E + K + + + S + S +++T
Sbjct: 892 KPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKES-INIT 950
Query: 686 DAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNR 745
++K HI+ + +SI++G +A S +E + +GKE+ K D +
Sbjct: 951 NSK-----HIQEEKKSSIVDGNKAQHEKPL-SLKEKTKDEPLKTPDGKEKDKKDKDIDRY 1004
Query: 746 NDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRK 805
+ +++ + L + K AD K S + K+ ++++D E K
Sbjct: 1005 KERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLK 1064
Query: 806 DVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDED 865
D++ + K K +IK+ ++ CL E K K+KE
Sbjct: 1065 DLEIEQWHKKHKEKIKQKEKERLRNRNCL--------ELKIKDKE--------------- 1101
Query: 866 EEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRK 925
K K TPT E K K L S SEV + K D S++ D K
Sbjct: 1102 ----KTKHTPT------ESKNKELTR----SKSSEVTDAYTKEKQPKDAVSNRSQSVDTK 1147
Query: 926 DVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTV---AEEESCSPSV 982
+V TL + SD SP + G++ S+ + + E+SC +V
Sbjct: 1148 NV----------MTLGKSSFVSDNSLNRSPRSENEKPGLSSRSVSMISVASSEDSCHTTV 1197
Query: 983 ELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVLNTPPT-TPESPSSVTVTEGSR- 1040
+ PPV DS + +E ++ + F S S+ +P E S + E +
Sbjct: 1198 TTPR-PPVEYDS----DFMLESSESQMSFSQSPFLSIAKSPALHERELDSLADLPERIKP 1252
Query: 1041 -QQSSVTVSEPLAPNQEEVRSIKSETDSTIEV------DSVAGELQDLQSEGNSSPAGFD 1093
+ ++ S + + E+V+ I SE TIEV + + Q+ S G
Sbjct: 1253 PYANRLSTSHLRSSSVEDVKLIISEGRPTIEVRRCSMPSVICEHTKQFQTISEESNQGSL 1312
Query: 1094 ASVSSSSSNQPEPE 1107
+V +S P+PE
Sbjct: 1313 LTVPGDTSPSPKPE 1326
Score = 52.8 bits (125), Expect = 2e-06
Identities = 165/884 (18%), Positives = 330/884 (37%), Gaps = 125/884 (14%)
Query: 452 EKPIEDEIERKENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVD 511
E+P++ + E ++ L + L + +++D E+ ++ +EN+D + + + +
Sbjct: 262 ERPVD--VAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLIC 319
Query: 512 ESLNI---------KVEAEEEKAKSGDETNKEEDEDDEEAEEEEEEEEEEEDEDDDDNNE 562
ES I ++ E K +E NK D+ +E+ +E E E ++ +
Sbjct: 320 ESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQ 379
Query: 563 EEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGGEVLYLVHYCG---WNVRYDEWI 619
E+ F YP K + + K ++ +S + SD E + + C D
Sbjct: 380 EKAF--YPKSFKSK----KQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQT 433
Query: 620 KADKIVRPADKNVPKIKHRKKIKNKLDKEKD-KDEKYSPKNCKLRRLS------------ 666
K + +V K K+K + K +NK + ++ K EK +N ++ L+
Sbjct: 434 KKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTR 493
Query: 667 -KPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGA 725
+ F+ + SP+ + L L KS + + L+ Q++ E ++ G+
Sbjct: 494 EEGNFRKSFSPKDDTSLHLFHISTG-----KSPKHSCGLSEKQSTPLKQEHTKTCLSPGS 548
Query: 726 QDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLR-K 784
+M + + N ++ + + S +E H + KS +++ +
Sbjct: 549 SEM----SLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDE 604
Query: 785 DIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEE 844
D E++D ++ K+ K +KK + + K K E+ S + +
Sbjct: 605 DHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQR 664
Query: 845 KAKNKESLCMENSSNSSSDED-----EEETKAKMTPTKKYNGLEEKRKSLRTT--GFYSG 897
+ EN S ED E E+ +T KK + LE+ K ++T S
Sbjct: 665 SVEFDREFWKENFFKSDETEDLFLNMEHES---LTLEKK-SKLEKNIKDDKSTKEKHVSK 720
Query: 898 FSEVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPH 957
E+R K+ S++ + + KD K+ +I +D D+E S
Sbjct: 721 ERNFKEERDKIKKESEKSFREEKIKDLKEERENIP------------TDKDSE-FTSLGM 767
Query: 958 PAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSN 1017
A EE + ++ + E ++ K P I+EK +E +RK
Sbjct: 768 SAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEK--RSQIKEKDIEKMERK--------- 816
Query: 1018 SVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGE 1077
T E + E ++ + +SE + +E+ + T+ + +
Sbjct: 817 --------TFEKEKKIK-HEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKN 867
Query: 1078 LQDLQSEGNSSPAGFDASVSSSSSNQPEPEH-----PEKACTGQKRVKDAQGGGSSSKKQ 1132
++ + + + +PE E EK +K + S S+K
Sbjct: 868 TAAIKKTDDREKSR-EKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKG 926
Query: 1133 KRSHKATVVNNKKKGKG------TNSSDSEELSAGESITKSQPVKSVSTGMKSHSTKSPA 1186
K K ++ K+K + TNS +E + ++ +K + P
Sbjct: 927 KNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPL 986
Query: 1187 RTQSPGKCGKNGDKDPDLKEPSNRLPKVYKWSFQMSDLENMTS----------------- 1229
+T GK DKD D + ++ +K Q++ L + S
Sbjct: 987 KTPD-GKEKDKKDKDIDRYKERDK----HKDKIQINSLLKLKSEADKPKPKSSPASKDTR 1041
Query: 1230 -AERITILQEKLQEIRKHYLSLKS-EVASIDRRRK-RLKKKERE 1270
E+ + + +Q + LSLK E+ ++ K ++K+KE+E
Sbjct: 1042 PKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKE 1085
Score = 49.3 bits (116), Expect = 2e-05
Identities = 218/1143 (19%), Positives = 412/1143 (36%), Gaps = 180/1143 (15%)
Query: 256 HKSRTIPANWKTE--LKEDSSSSEAEEEEE----EEDDEKEKEDNSSEEEEEIEPFPEER 309
H+S T+ K E +K+D S+ E +E EE D+ +KE S EE+I+ EER
Sbjct: 692 HESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEER 751
Query: 310 ENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDL 369
EN P +K + +L G IE V +++
Sbjct: 752 ENI-------------PTDKDS--EFTSL-------------GMSAIEESIGLHLVEKEI 783
Query: 370 GIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQMALPEKVVNKQCKECENVKEI--K 427
I + + K+ ++ + F+ K +K K+ ++ E K
Sbjct: 784 DIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDK 843
Query: 428 VKEENET---EIKEIKMEEERNIIPREEKPIEDEIERKENI-----KPSLGSKKNLLESI 479
+KE+++ ++ E E++ K +D + +E + K +++L ES
Sbjct: 844 IKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESK 903
Query: 480 PTHSDQEK------------EVNIKKPEDNENLDDKDDDTTRVDESLNI--KVEAEEEKA 525
H ++K E K +D E LD K + +R ES+NI +EEK
Sbjct: 904 EKHLMEKKNKQSDNSEYSKSEKGKNKEKDRE-LDKK--EKSRDKESINITNSKHIQEEKK 960
Query: 526 KSGDETNKEEDE---------DDEEAEEEEEEEEEEEDEDDDDNNEEE------------ 564
S + NK + E DE + + +E++++D+D D E +
Sbjct: 961 SSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLL 1020
Query: 565 ----EFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIK 620
E + P + R K +++ + + E L + W+ ++ E IK
Sbjct: 1021 KLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIK 1080
Query: 621 ADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVS 680
+ R ++N ++K + DKEK K KN +L R + E
Sbjct: 1081 QKEKERLRNRNCLELKIK-------DKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQP 1133
Query: 681 KLDLTDAKNS-DTAHIKSIEITSIL--NGLQASESSAEDSEQEDERGAQDMDNNGKEESK 737
K +++ S DT ++ ++ +S + N L S S + R + E+S
Sbjct: 1134 KDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLSSRSVSMISVASSEDSC 1193
Query: 738 IDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISK--PVSKSPERLRKDIEVLSEDTDY 795
+T R + E +S +LE ++ S ++KSP ++++ L++
Sbjct: 1194 HTTVTTPRPPV----EYDSDFMLESSESQMSFSQSPFLSIAKSPALHERELDSLAD---- 1245
Query: 796 EEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCME 855
+ +K ++ S ++ + + + G P + + +C
Sbjct: 1246 -------LPERIKPPYANRLSTSHLRSSSVE--DVKLIISEGRPTIEVRRCSMPSVICEH 1296
Query: 856 NSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDER 915
+ E+ + P + + FS V E+ + ++N
Sbjct: 1297 TKQFQTISEESNQGSLLTVPGDTSPSPKPE-----------VFSNVPERDLSNVSNIHSS 1345
Query: 916 LQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPH--PAPEEGVAE------- 966
S + S K T SP H P+ + GV +
Sbjct: 1346 FATSPTGASNSKYVSADRNLIKNTAPV------NTVMDSPVHLEPSSQVGVIQNKSWEMP 1399
Query: 967 -ESLQTVAEEE-----SCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFP--SSGSNS 1018
+ L+T++ + S P E N ++K ++E ++ R+ E P S +
Sbjct: 1400 VDRLETLSTRDFICPNSNIPDQESSLQSFCNSENKVLKENADFLSLRQTELPGNSCAQDP 1459
Query: 1019 VLNTPPTTPESPSSVTVTEGSRQQSSVTVS-----EPLAPNQEEV-----RSIKSETDST 1068
PP P S S ++++ +++S EP Q+ ++ ++ +ST
Sbjct: 1460 ASFMPPQQPCSFPSQSLSDAESISKHMSLSYVANQEPGILQQKNAVQIISSALDTDNEST 1519
Query: 1069 IEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSS 1128
+ ++ L D+Q P D+++ +S N EKA T + GS
Sbjct: 1520 KDTENTF-VLGDVQKTDAFVPVYSDSTIQEASPNF------EKAYTLPVLPSEKDFNGSD 1572
Query: 1129 SKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESITKSQPVKSVSTGMKSHSTKSPART 1188
+ Q +H A K G +S + S K ++S+ S
Sbjct: 1573 ASTQLNTHYAFSKLTYKSSSGHEVENSTTDTQVISHEKENKLESLVLTHLSRCDSDLCEM 1632
Query: 1189 QSPGKCGKNGDKDP-DLKEPSNRLPKVYKWSFQMSDLENMTSAERITILQEKLQEIRKHY 1247
+ G ++DP E L + Q S L ++ + + Q E+ K+
Sbjct: 1633 NAGMPKGNLNEQDPKHCPESEKCLLSIEDEESQQSILSSLENHSQ----QSTQPEMHKYG 1688
Query: 1248 LSLKSEV---ASIDRRRKRL-KKKERESAATSSSSSSPSSSSITAAVMLTLAEPSMSSAS 1303
+K E+ A D+ ++ ++ R A T ++ S +S T L+E S+S
Sbjct: 1689 QLVKVELEENAEDDKTENQIPQRMTRNKANTMANQSKQILASCT-----LLSEKDSESSS 1743
Query: 1304 QNG 1306
G
Sbjct: 1744 PRG 1746
>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
Length = 2062
Score = 84.3 bits (207), Expect = 7e-16
Identities = 167/734 (22%), Positives = 293/734 (39%), Gaps = 123/734 (16%)
Query: 401 NIEFQMALPEKV--VNKQCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDE 458
N+E + EK + K K+ ++ KE V +E + + K+++E REEK I+D
Sbjct: 712 NMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEK-IKDL 770
Query: 459 IERKENIKPSLGSKKNLL------ESIPTHSDQEKEVNIKKPEDN-ENLDDKDDDTTRVD 511
E +ENI S+ L ESI H EKE++I+K E + + +K + +++
Sbjct: 771 KEERENIPTDKDSEFTSLGMSAIEESIGLHL-VEKEIDIEKQEKHIKESKEKPEKRSQIK 829
Query: 512 ESLNIKVEAEEEKAKSGDETNKEEDEDDEEAEEEEEEEEEEEDEDDDDNNEEEEFECYPP 571
E + E+ + K+ ++ K + E E ++ + E ++ ++ D +C+
Sbjct: 830 EK-----DIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKE 884
Query: 572 GMKVQVRYGRGKNQKMYEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIKADKIVRPADKN 631
G K KN A+IK +D D +K+ R DK
Sbjct: 885 GEK-------SKNT----AAIKKTD-------------------DREKSREKMDRKHDKE 914
Query: 632 VP-KIKH-----RKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLT 685
P K +H K + K +K+ D E + K + + + S + S +++T
Sbjct: 915 KPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKES-INIT 973
Query: 686 DAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNR 745
++K HI+ + +SI++G +A S +E + +GKE+ K D +
Sbjct: 974 NSK-----HIQEEKKSSIVDGNKAQHEKPL-SLKEKTKDEPLKTPDGKEKDKKDKDIDRY 1027
Query: 746 NDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRK 805
+ +++ + L + K AD K S + K+ ++++D E K
Sbjct: 1028 KERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLK 1087
Query: 806 DVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDED 865
D++ + K K +IK+ ++ CL E K K+KE
Sbjct: 1088 DLEIEQWHKKHKEKIKQKEKERLRNRNCL--------ELKIKDKE--------------- 1124
Query: 866 EEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRK 925
K K TPT E K K L S SEV + K D S++ D K
Sbjct: 1125 ----KTKHTPT------ESKNKELTR----SKSSEVTDAYTKEKQPKDAVSNRSQSVDTK 1170
Query: 926 DVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTV---AEEESCSPSV 982
+V TL + SD SP + G++ S+ + + E+SC +V
Sbjct: 1171 NV----------MTLGKSSFVSDNSLNRSPRSENEKPGLSSRSVSMISVASSEDSCHTTV 1220
Query: 983 ELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVLNTPPT-TPESPSSVTVTEGSR- 1040
+ PPV DS + +E ++ + F S S+ +P E S + E +
Sbjct: 1221 TTPR-PPVEYDS----DFMLESSESQMSFSQSPFLSIAKSPALHERELDSLADLPERIKP 1275
Query: 1041 -QQSSVTVSEPLAPNQEEVRSIKSETDSTIEV------DSVAGELQDLQSEGNSSPAGFD 1093
+ ++ S + + E+V+ I SE TIEV + + Q+ S G
Sbjct: 1276 PYANRLSTSHLRSSSVEDVKLIISEGRPTIEVRRCSMPSVICEHTKQFQTISEESNQGSL 1335
Query: 1094 ASVSSSSSNQPEPE 1107
+V +S P+PE
Sbjct: 1336 LTVPGDTSPSPKPE 1349
Score = 52.8 bits (125), Expect = 2e-06
Identities = 165/884 (18%), Positives = 330/884 (37%), Gaps = 125/884 (14%)
Query: 452 EKPIEDEIERKENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVD 511
E+P++ + E ++ L + L + +++D E+ ++ +EN+D + + + +
Sbjct: 285 ERPVD--VAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLIC 342
Query: 512 ESLNI---------KVEAEEEKAKSGDETNKEEDEDDEEAEEEEEEEEEEEDEDDDDNNE 562
ES I ++ E K +E NK D+ +E+ +E E E ++ +
Sbjct: 343 ESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQ 402
Query: 563 EEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGGEVLYLVHYCG---WNVRYDEWI 619
E+ F YP K + + K ++ +S + SD E + + C D
Sbjct: 403 EKAF--YPKSFKSK----KQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQT 456
Query: 620 KADKIVRPADKNVPKIKHRKKIKNKLDKEKD-KDEKYSPKNCKLRRLS------------ 666
K + +V K K+K + K +NK + ++ K EK +N ++ L+
Sbjct: 457 KKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTR 516
Query: 667 -KPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGA 725
+ F+ + SP+ + L L KS + + L+ Q++ E ++ G+
Sbjct: 517 EEGNFRKSFSPKDDTSLHLFHISTG-----KSPKHSCGLSEKQSTPLKQEHTKTCLSPGS 571
Query: 726 QDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLR-K 784
+M + + N ++ + + S +E H + KS +++ +
Sbjct: 572 SEM----SLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDE 627
Query: 785 DIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEE 844
D E++D ++ K+ K +KK + + K K E+ S + +
Sbjct: 628 DHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQR 687
Query: 845 KAKNKESLCMENSSNSSSDED-----EEETKAKMTPTKKYNGLEEKRKSLRTT--GFYSG 897
+ EN S ED E E+ +T KK + LE+ K ++T S
Sbjct: 688 SVEFDREFWKENFFKSDETEDLFLNMEHES---LTLEKK-SKLEKNIKDDKSTKEKHVSK 743
Query: 898 FSEVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPH 957
E+R K+ S++ + + KD K+ +I +D D+E S
Sbjct: 744 ERNFKEERDKIKKESEKSFREEKIKDLKEERENIP------------TDKDSE-FTSLGM 790
Query: 958 PAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSN 1017
A EE + ++ + E ++ K P I+EK +E +RK
Sbjct: 791 SAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEK--RSQIKEKDIEKMERK--------- 839
Query: 1018 SVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGE 1077
T E + E ++ + +SE + +E+ + T+ + +
Sbjct: 840 --------TFEKEKKIK-HEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKN 890
Query: 1078 LQDLQSEGNSSPAGFDASVSSSSSNQPEPEH-----PEKACTGQKRVKDAQGGGSSSKKQ 1132
++ + + + +PE E EK +K + S S+K
Sbjct: 891 TAAIKKTDDREKSR-EKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKG 949
Query: 1133 KRSHKATVVNNKKKGKG------TNSSDSEELSAGESITKSQPVKSVSTGMKSHSTKSPA 1186
K K ++ K+K + TNS +E + ++ +K + P
Sbjct: 950 KNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPL 1009
Query: 1187 RTQSPGKCGKNGDKDPDLKEPSNRLPKVYKWSFQMSDLENMTS----------------- 1229
+T GK DKD D + ++ +K Q++ L + S
Sbjct: 1010 KTPD-GKEKDKKDKDIDRYKERDK----HKDKIQINSLLKLKSEADKPKPKSSPASKDTR 1064
Query: 1230 -AERITILQEKLQEIRKHYLSLKS-EVASIDRRRK-RLKKKERE 1270
E+ + + +Q + LSLK E+ ++ K ++K+KE+E
Sbjct: 1065 PKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKE 1108
Score = 49.3 bits (116), Expect = 2e-05
Identities = 218/1143 (19%), Positives = 412/1143 (36%), Gaps = 180/1143 (15%)
Query: 256 HKSRTIPANWKTE--LKEDSSSSEAEEEEE----EEDDEKEKEDNSSEEEEEIEPFPEER 309
H+S T+ K E +K+D S+ E +E EE D+ +KE S EE+I+ EER
Sbjct: 715 HESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEER 774
Query: 310 ENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDL 369
EN P +K + +L G IE V +++
Sbjct: 775 ENI-------------PTDKDS--EFTSL-------------GMSAIEESIGLHLVEKEI 806
Query: 370 GIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQMALPEKVVNKQCKECENVKEI--K 427
I + + K+ ++ + F+ K +K K+ ++ E K
Sbjct: 807 DIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDK 866
Query: 428 VKEENET---EIKEIKMEEERNIIPREEKPIEDEIERKENI-----KPSLGSKKNLLESI 479
+KE+++ ++ E E++ K +D + +E + K +++L ES
Sbjct: 867 IKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESK 926
Query: 480 PTHSDQEK------------EVNIKKPEDNENLDDKDDDTTRVDESLNI--KVEAEEEKA 525
H ++K E K +D E LD K + +R ES+NI +EEK
Sbjct: 927 EKHLMEKKNKQSDNSEYSKSEKGKNKEKDRE-LDKK--EKSRDKESINITNSKHIQEEKK 983
Query: 526 KSGDETNKEEDE---------DDEEAEEEEEEEEEEEDEDDDDNNEEE------------ 564
S + NK + E DE + + +E++++D+D D E +
Sbjct: 984 SSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLL 1043
Query: 565 ----EFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIK 620
E + P + R K +++ + + E L + W+ ++ E IK
Sbjct: 1044 KLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIK 1103
Query: 621 ADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVS 680
+ R ++N ++K + DKEK K KN +L R + E
Sbjct: 1104 QKEKERLRNRNCLELKIK-------DKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQP 1156
Query: 681 KLDLTDAKNS-DTAHIKSIEITSIL--NGLQASESSAEDSEQEDERGAQDMDNNGKEESK 737
K +++ S DT ++ ++ +S + N L S S + R + E+S
Sbjct: 1157 KDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLSSRSVSMISVASSEDSC 1216
Query: 738 IDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISK--PVSKSPERLRKDIEVLSEDTDY 795
+T R + E +S +LE ++ S ++KSP ++++ L++
Sbjct: 1217 HTTVTTPRPPV----EYDSDFMLESSESQMSFSQSPFLSIAKSPALHERELDSLAD---- 1268
Query: 796 EEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCME 855
+ +K ++ S ++ + + + G P + + +C
Sbjct: 1269 -------LPERIKPPYANRLSTSHLRSSSVE--DVKLIISEGRPTIEVRRCSMPSVICEH 1319
Query: 856 NSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDER 915
+ E+ + P + + FS V E+ + ++N
Sbjct: 1320 TKQFQTISEESNQGSLLTVPGDTSPSPKPE-----------VFSNVPERDLSNVSNIHSS 1368
Query: 916 LQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPH--PAPEEGVAE------- 966
S + S K T SP H P+ + GV +
Sbjct: 1369 FATSPTGASNSKYVSADRNLIKNTAPV------NTVMDSPVHLEPSSQVGVIQNKSWEMP 1422
Query: 967 -ESLQTVAEEE-----SCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFP--SSGSNS 1018
+ L+T++ + S P E N ++K ++E ++ R+ E P S +
Sbjct: 1423 VDRLETLSTRDFICPNSNIPDQESSLQSFCNSENKVLKENADFLSLRQTELPGNSCAQDP 1482
Query: 1019 VLNTPPTTPESPSSVTVTEGSRQQSSVTVS-----EPLAPNQEEV-----RSIKSETDST 1068
PP P S S ++++ +++S EP Q+ ++ ++ +ST
Sbjct: 1483 ASFMPPQQPCSFPSQSLSDAESISKHMSLSYVANQEPGILQQKNAVQIISSALDTDNEST 1542
Query: 1069 IEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSS 1128
+ ++ L D+Q P D+++ +S N EKA T + GS
Sbjct: 1543 KDTENTF-VLGDVQKTDAFVPVYSDSTIQEASPNF------EKAYTLPVLPSEKDFNGSD 1595
Query: 1129 SKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESITKSQPVKSVSTGMKSHSTKSPART 1188
+ Q +H A K G +S + S K ++S+ S
Sbjct: 1596 ASTQLNTHYAFSKLTYKSSSGHEVENSTTDTQVISHEKENKLESLVLTHLSRCDSDLCEM 1655
Query: 1189 QSPGKCGKNGDKDP-DLKEPSNRLPKVYKWSFQMSDLENMTSAERITILQEKLQEIRKHY 1247
+ G ++DP E L + Q S L ++ + + Q E+ K+
Sbjct: 1656 NAGMPKGNLNEQDPKHCPESEKCLLSIEDEESQQSILSSLENHSQ----QSTQPEMHKYG 1711
Query: 1248 LSLKSEV---ASIDRRRKRL-KKKERESAATSSSSSSPSSSSITAAVMLTLAEPSMSSAS 1303
+K E+ A D+ ++ ++ R A T ++ S +S T L+E S+S
Sbjct: 1712 QLVKVELEENAEDDKTENQIPQRMTRNKANTMANQSKQILASCT-----LLSEKDSESSS 1766
Query: 1304 QNG 1306
G
Sbjct: 1767 PRG 1769
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 84.3 bits (207), Expect = 7e-16
Identities = 175/900 (19%), Positives = 348/900 (38%), Gaps = 130/900 (14%)
Query: 408 LPEKVVNKQCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKP 467
LP K V K+ KE + +V + N E K K+E + ++ +++KPI+ E KP
Sbjct: 552 LPSKSVRKESKE----ETPEVTKVNHVE-KPPKVESKEKVMVKKDKPIKTET------KP 600
Query: 468 SLGSKK--NLLESIPTHSD-QEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEK 524
S+ K+ + E P ++ EK+ KP+ + K + + ++ K + ++E
Sbjct: 601 SVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEV 660
Query: 525 AKSGDETNKEEDEDDEEAEEEEEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKN 584
AK D+T +++E ++ E ++E ++E + E+ + +E + E P +K +V+ K
Sbjct: 661 AKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKE 720
Query: 585 QKMYEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKK---I 641
K E K + K+ + A K+ + KK +
Sbjct: 721 VKKEEKEPKK-------------------------EIKKLPKDAKKSSTPLSEAKKPAAL 755
Query: 642 KNKLDKEKDKDEKYS-----PKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIK 696
K K+ K+++ +K S PK ++ K + + T A A I
Sbjct: 756 KPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIA 815
Query: 697 SIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQ-N 755
+I L ++ SS ED +D + EE + + +LI EE+
Sbjct: 816 AIGPAKELEAERSLMSSPEDL-------TKDFEELKAEEVDVTKDIKPQLELIEDEEKLK 868
Query: 756 SSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKS 815
+ +E + + ++K ++SP D + + + + E ++ ++ + V+K D
Sbjct: 869 ETEPVEAYVIQKEREVTKGPAESP-----DEGITTTEGEGECEQTPEELEPVEKQGVD-- 921
Query: 816 SKPQIKRGKRRYCNTEECLKTGSPGKK------EEKAKNKESLCMENSSNSSSDEDEEET 869
I++ + EE +TG +K EE ++ E ++S S EDEE
Sbjct: 922 ---DIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESA 978
Query: 870 KAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKDVWS 929
KA+ + EKR+S+ SG E + + + A +
Sbjct: 979 KAEADAY-----IREKRESVA-----SGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAED 1028
Query: 930 SIQGQW-PKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPP 988
+ + ++ P+K E + + + AA E G AEE + +P+ +L
Sbjct: 1029 AREEEYEPEKMEAEDYVMAVVDKAA-------EAGGAEEQYGFLT-----TPTKQLGAQS 1076
Query: 989 PVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVS 1048
P + I ++T+ S S + + + P T T G Q + S
Sbjct: 1077 PGREPASSIHDETLP--------GGSESEATASDEENREDQPEEFTATSGYTQSTIEISS 1128
Query: 1049 EPLAPNQEEV-RSIKSETDSTIEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSNQPEPE 1107
EP ++ R + S+ + E +S + E ++ +++S+ S ++P
Sbjct: 1129 EPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITK--------YESSLYSQEYSKPADV 1180
Query: 1108 HPEKACTGQKRVKDAQGGGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESITKS 1167
P + + G ++ S +++ +K + E+ A ++
Sbjct: 1181 TPLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLDIK 1240
Query: 1168 QPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDKDPDLKEPSNRLPKVYKWSFQMSDLENM 1227
+ +VS+ S S KSP+ + SP P E + + +S ++++
Sbjct: 1241 DSISAVSSEKVSPS-KSPSLSPSP----------PSPLEKTPLGERSVNFSLTPNEIKVS 1289
Query: 1228 TSAERITILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSSSSSPSSSSIT 1287
AE + E QE+ + + + + K L+ + T S+ +P S T
Sbjct: 1290 AEAEVAPVSPEVTQEVVEEHCASPED--------KTLEVVSPSQSVTGSAGHTPYYQSPT 1341
Score = 62.8 bits (151), Expect = 2e-09
Identities = 193/1013 (19%), Positives = 353/1013 (34%), Gaps = 225/1013 (22%)
Query: 209 KDNILVRSFKDGKFTSVPRKDVHEITSDTAPKP---DAVLKQAFEQALEFHKSRTIPANW 265
K+ ++V+ K K + P E+ S P P + KQA + + K +T+
Sbjct: 583 KEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKET 642
Query: 266 KTE----------------LKEDSSSSEAEEEEEEEDDEKE------------------- 290
K + KED + + EE+ ++E+ +KE
Sbjct: 643 KVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKK 702
Query: 291 -------KEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKL 343
K++ EE++E++ +E + +++L K + TP+++ + K
Sbjct: 703 ETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKK 762
Query: 344 FRLVHK--LGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSAN 401
V K + E G + + + +A G A G +
Sbjct: 763 EESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKE 822
Query: 402 IEFQ---MALPEKVVNKQCKECENVK--EIKVKEENETEIKEIKMEEERNIIPREEKPIE 456
+E + M+ PE + K+ E +K E+ V ++ + +++ I+ EE+ +E +P+E
Sbjct: 823 LEAERSLMSSPEDLT----KDFEELKAEEVDVTKDIKPQLELIEDEEKL----KETEPVE 874
Query: 457 DEIERKENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDK--DDDTTRVDESL 514
+ +KE + + G ++ E I T ++ E E + PE+ E ++ + DD DE
Sbjct: 875 AYVIQKER-EVTKGPAESPDEGITT-TEGEGECE-QTPEELEPVEKQGVDDIEKFEDEGA 931
Query: 515 NIKVEAEEEKAKSGDETNKEEDEDDEEAEEEEEE----EEEEEDEDDDDNNEEEEFECYP 570
EE +++GD K E E+ EE EE+ EE + +D+ + + E + Y
Sbjct: 932 GF-----EESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYI 986
Query: 571 PGMKVQVRYGRGKNQKMYEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIKADKIVRPADK 630
+ V G + ++ + +I+ + E E DE KA+ R +
Sbjct: 987 REKRESVASGDDRAEEDMDEAIEKGEAEQSE-----------EEADEEDKAED-AREEEY 1034
Query: 631 NVPKIKHRKKIKNKLDKEKD---KDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDA 687
K++ + +DK + +E+Y F T P+ ++ A
Sbjct: 1035 EPEKMEAEDYVMAVVDKAAEAGGAEEQYG-------------FLTTPTKQL-------GA 1074
Query: 688 KNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRND 747
++ SI ++ G + SE++A D E +++ + +G +S I
Sbjct: 1075 QSPGREPASSIHDETLPGGSE-SEATASDEENREDQPEEFTATSGYTQSTI--------- 1124
Query: 748 LISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDV 807
E+ SE T +E +DV
Sbjct: 1125 ---------------------------------------EISSEPTPMDE---MSTPRDV 1142
Query: 808 KKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDED-- 865
D T N EE T SP ++ ES + +D
Sbjct: 1143 MSDET----------------NNEE---TESPSQEFVNITKYESSLYSQEYSKPADVTPL 1183
Query: 866 ---EEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAK 922
E +K T K YN S T S E R L + ++ S
Sbjct: 1184 NGFSEGSKTDATDGKDYNA------SASTISPPSSMEEDKFSRSALRDAYCSEVKASTTL 1237
Query: 923 DRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSV 982
D KD S++ + ++ + SPP P + + E S+ S
Sbjct: 1238 DIKDSISAVSSE-------KVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSA 1290
Query: 983 ELE-KPPPVNVDSKPIEEKTVEVNDRKAEFPS-----SGS-------------------N 1017
E E P V + +EE D+ E S +GS
Sbjct: 1291 EAEVAPVSPEVTQEVVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPT 1350
Query: 1018 SVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGE 1077
V+ PP P S + + + S + EP+ ++ + + S S + S +
Sbjct: 1351 EVIEKPPAVPVSFEFSDAKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAY 1410
Query: 1078 LQDLQSEGNSSPAGFDASVSSSSSNQPEPEH--PEKACTGQKRVKDAQGGGSS 1128
L ++ +S G ++ S Q P+ P T +D Q G S+
Sbjct: 1411 ESFLSADDKASGRGAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKST 1463
Score = 57.8 bits (138), Expect = 7e-08
Identities = 126/625 (20%), Positives = 244/625 (39%), Gaps = 92/625 (14%)
Query: 197 VCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTAPKPDAVLKQAFEQALEFH 256
V P + E VKK+ + K + P+K+V + T K + E
Sbjct: 628 VKPKAAKEKTVKKETKVKPEDKKEE-KEKPKKEVAKKEDKTPIKKE-----------EKP 675
Query: 257 KSRTIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQL 316
K + K E+K++ +E ++E ++ K++ EE++E++ +E + +++L
Sbjct: 676 KKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKL 735
Query: 317 YKFMEDRGTPINK-------RPVLGYRNLNLFK------------LFRLVHKLGGFDN-- 355
K + TP+++ +P + + ++ K +++ K G
Sbjct: 736 PKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAV 795
Query: 356 ---IESGAVWKQVYQDLGIPVLNSA----AGYNVKCAYKKYLYGFEEYCR-----SANIE 403
+ +GA V GI + A A ++ + + FEE + +I+
Sbjct: 796 AAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIK 855
Query: 404 FQMALPEKVVNKQCKECENVKEIKVKEENETE----------IKEIKMEEERNIIPREEK 453
Q+ L E ++ KE E V+ +++E E I + E E P E +
Sbjct: 856 PQLELIED--EEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELE 913
Query: 454 PIE----DEIERKENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTR 509
P+E D+IE+ E+ + +E E + E++ + T
Sbjct: 914 PVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTE 973
Query: 510 VDESLNIKVEA----EEEKAKSGDETNKEEDEDDEEAEEEEEEEEEEEDEDDDDNNEEEE 565
+ES + +A + E SGD+ +E+ ++ E E E+ EEE ++ED ++ EEE
Sbjct: 974 DEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAREEE 1033
Query: 566 FECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIKADKIV 625
+E P M+ + Y ++ D E G G+ + + A
Sbjct: 1034 YE--PEKMEAE----------DYVMAVVDKAAEAGGA---EEQYGFLTTPTKQLGAQSPG 1078
Query: 626 R-PA----DKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVS 680
R PA D+ +P + + + +D+ E+++ + + + + P EM +
Sbjct: 1079 REPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDEMST 1138
Query: 681 KLD-LTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKID 739
D ++D N++ S E +I ESS QE + A NG E
Sbjct: 1139 PRDVMSDETNNEETESPSQEFVNITK----YESSL--YSQEYSKPADVTPLNGFSEGSKT 1192
Query: 740 HLTNNRNDLISKEEQNSSSLLEENK 764
T+ ++ S + S +EE+K
Sbjct: 1193 DATDGKDYNASASTISPPSSMEEDK 1217
Score = 44.7 bits (104), Expect = 6e-04
Identities = 64/313 (20%), Positives = 128/313 (40%), Gaps = 41/313 (13%)
Query: 994 SKPIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGS--RQQSSVTVSEPL 1051
+KP+ K+V + K E P + + PP ES V V + + ++ +V+E
Sbjct: 549 AKPLPSKSVR-KESKEETPEVTKVNHVEKPPKV-ESKEKVMVKKDKPIKTETKPSVTEKE 606
Query: 1052 APNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSNQPEPEHPEK 1111
P++EE +K+ E+ + Q+ A + +V + +PE + EK
Sbjct: 607 VPSKEEPSPVKA-------------EVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEK 653
Query: 1112 ACTGQKRVKDAQGGGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESITKSQPVK 1171
++ K + + KK+++ K V KK E+ + + K P K
Sbjct: 654 EKPKKEVAK--KEDKTPIKKEEKPKKEEVKKEVKK----EIKKEEKKEPKKEVKKETPPK 707
Query: 1172 SVSTGMKSHSTKSPARTQSPGKCGKNGDKDPDLKEPSNRLPKVYKWSFQMSDLENMTSAE 1231
V +K K K +K+P K+ +LPK K S ++ A+
Sbjct: 708 EVKKEVKKEEKKEV----------KKEEKEP--KKEIKKLPKDAKKS-----STPLSEAK 750
Query: 1232 RITILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSSSSSPSSSSITAAVM 1291
+ L+ K+ + ++ + S A + + ++K ++E A + +++ + + TAAVM
Sbjct: 751 KPAALKPKVPK-KEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVM 809
Query: 1292 LTLAEPSMSSASQ 1304
++ A +
Sbjct: 810 AAAGIAAIGPAKE 822
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 82.8 bits (203), Expect = 2e-15
Identities = 136/608 (22%), Positives = 241/608 (39%), Gaps = 67/608 (11%)
Query: 492 KKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGDETNKEEDEDDEEAEEEEEEEEE 551
K P + ++ K ++ +V E + EE+ + T + +E+++EA+EEE +EEE
Sbjct: 428 KIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEE 487
Query: 552 EEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGGEVLYLVHYCGW 611
+E++ + EEE PP + K+ EA S E
Sbjct: 488 GGEEEEAEGGEEETKS--PPAEEAASPEKEAKSPVKEEAK---SPAEAKSPEKEEAKSPA 542
Query: 612 NVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLD---------KEKDKDEKYSPKNCKL 662
V+ E KA + K+ P+ K +K + K K K+E SP K
Sbjct: 543 EVKSPE--KAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKS 600
Query: 663 RRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQA-SESSAEDSEQED 721
+K P + +K + + S A +KS E +A S A+ E+E+
Sbjct: 601 PEKAKSPVKEEAKSPAEAKSPVKEEAKS-PAEVKSPEKAKSPTKEEAKSPEKAKSPEKEE 659
Query: 722 ERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVIS--KPVSKSP 779
+ + + K E+K + +K + + S ++E + S K +KSP
Sbjct: 660 AKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSP 719
Query: 780 ERLRKDIEVLSEDTDYEEDEVTKKRKDVKK-DTTDKSSKPQIKRGKRRYCNTEECL---- 834
E+ + ++ ++ + + V ++ K +K + +K+ +K + + EE
Sbjct: 720 EKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPAD 779
Query: 835 ----KTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLR 890
K SP K+E K+ K ++ + + E ++ + K +P K+ EEK +
Sbjct: 780 KFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVK-SPVKE----EEKPQ--- 831
Query: 891 TTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTE 950
EV K ++ + +++KD S + + PKK + + E
Sbjct: 832 ---------EVKVKEPPKKAEEEKAPATPKTEEKKD---SKKEEAPKKEAPKPKVEEKKE 879
Query: 951 AAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNV--DSKPIEEKTV---EVN 1005
A P + E EE AE++ P+ E E P V V D+KP E+ V E +
Sbjct: 880 PAVEKPKESKVEAKKEE-----AEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPD 934
Query: 1006 DRKAEFPS------SGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVS-EPLAPNQEEV 1058
D KA+ PS + +T + P TE ++ T+S EP P E+
Sbjct: 935 DAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKA 994
Query: 1059 RSIKSETD 1066
S TD
Sbjct: 995 EK-SSSTD 1001
Score = 80.5 bits (197), Expect = 1e-14
Identities = 150/664 (22%), Positives = 251/664 (37%), Gaps = 64/664 (9%)
Query: 366 YQDLGIPVLNSAAGYNVK-CAYKKYLYGFEEYCRSANIEFQMALPEKV-----VNKQCKE 419
YQDL LN +++ AY+K L G E CR +LPE + V+ K
Sbjct: 385 YQDL----LNVKMALDIEIAAYRKLLEG--EECRIGFGPIPFSLPEGLPKIPSVSTHIK- 437
Query: 420 CENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLE-- 477
++ ++IKV E++E E ++ + E + E E++ ++E K G ++ E
Sbjct: 438 VKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGG 497
Query: 478 -----SIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGDETN 532
S P E K P E + + +E+ + EKAKS
Sbjct: 498 EEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKS---PA 554
Query: 533 KEEDEDDEEAEEEEEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEASI 592
KEE + EA+ E+EE + E + P + K+ + ++ +
Sbjct: 555 KEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKS------PAKEEAKSPAEAKSPEKAKSPV 608
Query: 593 KDSDVEGGEVLYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKD 652
K+ E V E K+ V+ +K K K K K +K+
Sbjct: 609 KEEAKSPAEAKSPV---------KEEAKSPAEVKSPEKAKSPTKEEAKSPEKA-KSPEKE 658
Query: 653 EKYSPKNCK--LRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIE-ITSILNGLQA 709
E SP+ K ++ +K P + SP AK+ KS E S +
Sbjct: 659 EAKSPEKAKSPVKAEAKSP-EKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAK 717
Query: 710 SESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNN---RNDLISKEEQNSSSLLEENKVH 766
S A+ +E+ + + + KEE+K + L K + + EE +
Sbjct: 718 SPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSP 777
Query: 767 ADLVISKPVS------KSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQI 820
AD K S KSPE+ + L ED E E+ KK + K + KPQ
Sbjct: 778 ADKFPEKAKSPVKEEVKSPEKAKSP---LKEDAKAPEKEIPKKEE--VKSPVKEEEKPQE 832
Query: 821 KRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYN 880
+ K EE +P +E+K KE + + +E +E K +K
Sbjct: 833 VKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESK--- 889
Query: 881 GLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWP--KK 938
+E K++ + A ++++ ++ + + AK D + + P KK
Sbjct: 890 -VEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKK 948
Query: 939 TLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPVN-VDSKPI 997
D+ E A P E A+E +T+++E S + + EK + DSKP
Sbjct: 949 EAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPP 1008
Query: 998 EEKT 1001
E+ T
Sbjct: 1009 EKAT 1012
Score = 50.4 bits (119), Expect = 1e-05
Identities = 72/300 (24%), Positives = 107/300 (35%), Gaps = 41/300 (13%)
Query: 948 DTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPP-----PVNVDSK-PIEEKT 1001
+ E A EEG EE + EE P+ E P PV ++K P E K+
Sbjct: 473 EEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKS 532
Query: 1002 VEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEP---LAPNQEEV 1058
E + K+ + +SP E +S V P +P +EE
Sbjct: 533 PEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEA 592
Query: 1059 RSIKSETDSTIEVDSVAGELQDLQSEGNS-------SPAGFDASVSSSSSNQPEPEHPEK 1111
+S +E S + S E +E S SPA + + S + E + PEK
Sbjct: 593 KS-PAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEK 651
Query: 1112 ACTGQK-RVKDAQGGGSSSKKQKRS-----------------HKATVVNNKKKGKGTNSS 1153
A + +K K + S K + +S K+ V K + S
Sbjct: 652 AKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSP 711
Query: 1154 DSEELSAGESITKSQPVKSVSTGMKSHS-----TKSPARTQSPGKCGKNGDKDPDLKEPS 1208
EE + E KS + T K+ S KSP + +SP K K P+ K P+
Sbjct: 712 VKEEAKSPEK-AKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPA 770
Score = 50.1 bits (118), Expect = 1e-05
Identities = 79/375 (21%), Positives = 144/375 (38%), Gaps = 81/375 (21%)
Query: 236 DTAPKPDAVLKQAFEQALEFHKSRT-------IPANWKTELKEDSSSSEAEEEEEEED-- 286
+ A P+ E+A K+++ P K+ +KE++ S E + E+
Sbjct: 700 EEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTL 759
Query: 287 DEKEKEDNSSEEEEEIEP---FPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKL 343
D K E + +EE P FPE+ ++ +++ K E +P+ +
Sbjct: 760 DVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKE-------------- 805
Query: 344 FRLVHKLGGFDNIESGAVWKQV--YQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSAN 401
++ A K++ +++ PV VK +E + A
Sbjct: 806 -------------DAKAPEKEIPKKEEVKSPVKEEEKPQEVKV---------KEPPKKAE 843
Query: 402 IEFQMALPEKVVNKQCKECENVKEI----KVKEENETEI---KEIKME------EERNII 448
E A P+ K K+ E K+ KV+E+ E + KE K+E E++ +
Sbjct: 844 EEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKV 903
Query: 449 PREEKPIEDEIERKENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTT 508
P EK ++E KE+ KP K E D K KP + + + DT
Sbjct: 904 PTPEKEAPAKVEVKEDAKP-----KEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDT- 957
Query: 509 RVDESLNIKVEAEEEKAKSGDETNKEEDEDDEEAEEEEEEEEEEEDEDDDDNNEEEEFEC 568
+EEKAK +E K E + E+ + +E + + E + ++ ++ +
Sbjct: 958 ------------KEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDS 1005
Query: 569 YPPGMKVQVRYGRGK 583
PP + + +GK
Sbjct: 1006 KPPEKATEDKAAKGK 1020
Score = 48.1 bits (113), Expect = 5e-05
Identities = 88/465 (18%), Positives = 175/465 (37%), Gaps = 49/465 (10%)
Query: 409 PEKVVNKQCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPS 468
PEK + +E ++ E K E+ ++ +KE E + P+++E + +K
Sbjct: 581 PEKAKSPAKEEAKSPAEAKSPEKAKSPVKE-----EAKSPAEAKSPVKEEAKSPAEVKSP 635
Query: 469 LGSKKNLLESIPTHSDQEKEVNIKKPEDNE-NLDDKDDDTTRVD----ESLNIKVEAEEE 523
+K PT + + K PE E +K + + E V+AE +
Sbjct: 636 EKAKS------PTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAK 689
Query: 524 KAKSGDETNKEEDEDDEEAEEEEEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGK 583
+ KEE + E+A+ +EE + ++ EE + P K V+
Sbjct: 690 SPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKT---PEKAKSPVKEEAKS 746
Query: 584 NQKMYEAS-IKDSDVEGGEVLYLVHYCGWNVRYDEWIKADKIVRPADKNVPK-IKHRKKI 641
+K K DV+ E + + ADK A V + +K +K
Sbjct: 747 PEKAKSPEKAKTLDVKSPEAKT-------PAKEEARSPADKFPEKAKSPVKEEVKSPEKA 799
Query: 642 KNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHI--KSIE 699
K+ L ++ EK PK ++ K P + P+ V + + A K+ E
Sbjct: 800 KSPLKEDAKAPEKEIPKKEEV----KSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEE 855
Query: 700 ITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSL 759
+ + + +E + A + K E+K + + + ++E +
Sbjct: 856 KKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVE 915
Query: 760 LEEN---KVHADLVISKP---VSKSPERLRKDIEVLSEDTDYEEDEVTK---------KR 804
++E+ K ++ +P +K P + + E E D +E++ K K
Sbjct: 916 VKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKA 975
Query: 805 KDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNK 849
K+ K + + SKP+ ++ ++ ++ K +++ AK K
Sbjct: 976 KEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAKGK 1020
Score = 37.0 bits (84), Expect = 0.12
Identities = 30/96 (31%), Positives = 42/96 (43%), Gaps = 9/96 (9%)
Query: 218 KDGKFTSVPRKD-----VHEITSDTAPKPDAVLKQAFEQALEFHKSRTIP---ANWKTEL 269
KD K P+K+ V E KP +A ++ E K P A K E+
Sbjct: 857 KDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEV 916
Query: 270 KEDSSSSE-AEEEEEEEDDEKEKEDNSSEEEEEIEP 304
KED+ E E ++E DD K KE + E++E P
Sbjct: 917 KEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAP 952
Score = 36.6 bits (83), Expect = 0.16
Identities = 33/173 (19%), Positives = 66/173 (38%), Gaps = 8/173 (4%)
Query: 1144 KKKGKGTNSSDSEELSAGESITKSQPVKSVSTGMK------SHSTKSPARTQSPGKCGKN 1197
+++GK + EE GE TKS P + ++ K KSPA +SP K +
Sbjct: 480 EEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEK--EE 537
Query: 1198 GDKDPDLKEPSNRLPKVYKWSFQMSDLENMTSAERITILQEKLQEIRKHYLSLKSEVASI 1257
++K P + + + ++ E + + K E K +++ +
Sbjct: 538 AKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAE 597
Query: 1258 DRRRKRLKKKERESAATSSSSSSPSSSSITAAVMLTLAEPSMSSASQNGMSVE 1310
+ ++ K +E A + + + SP + + E + S + S E
Sbjct: 598 AKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPE 650
Score = 34.7 bits (78), Expect = 0.62
Identities = 52/298 (17%), Positives = 108/298 (36%), Gaps = 31/298 (10%)
Query: 1028 ESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGNS 1087
+S + V E S +++ + +E+ + + T E + A E + + EG
Sbjct: 439 KSEEKIKVVEKSEKETVIV--------EEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGE 490
Query: 1088 SPAGFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATVVNNKKKG 1147
+ S E PEK + + + S +++ + V + +K
Sbjct: 491 EEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKA 550
Query: 1148 KG-----------TNSSDSEELSAGESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCGK 1196
K S + EE + + + KS + KSPA +SP K K
Sbjct: 551 KSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPA----KEEAKSPAEAKSPEK-AK 605
Query: 1197 NGDKDPDLKEPSNRLPKVYKWSFQMSDLENMTSAERITILQEKLQEIRKHYLSLKSEVAS 1256
+ K+ + K P+ V + + +++++ A+ T +E+ + K K E S
Sbjct: 606 SPVKE-EAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPT--KEEAKSPEKAKSPEKEEAKS 662
Query: 1257 IDRRRKRLKKK----ERESAATSSSSSSPSSSSITAAVMLTLAEPSMSSASQNGMSVE 1310
++ + +K + E+ + + + SP + E + S + S E
Sbjct: 663 PEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPE 720
Score = 34.7 bits (78), Expect = 0.62
Identities = 26/89 (29%), Positives = 45/89 (50%), Gaps = 5/89 (5%)
Query: 225 VPRKDVHEITSDTAPKPDAVLKQAFEQALEFHKSRTIPANWKTELKEDSSSSEAEEEEEE 284
+P+K+ + KP V + + E K+ PA KTE K+DS EA ++E
Sbjct: 814 IPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKA---PATPKTEEKKDSKKEEAPKKEAP 870
Query: 285 EDDEKEKEDNSSE--EEEEIEPFPEEREN 311
+ +EK++ + E +E ++E EE E+
Sbjct: 871 KPKVEEKKEPAVEKPKESKVEAKKEEAED 899
Score = 32.7 bits (73), Expect = 2.3
Identities = 20/61 (32%), Positives = 32/61 (52%), Gaps = 2/61 (3%)
Query: 251 QALEFHKSRTIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERE 310
+ +E + T+ +TE E + E EEEE+E E+E ++ EEEE E EE +
Sbjct: 445 KVVEKSEKETVIVEEQTE--ETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETK 502
Query: 311 N 311
+
Sbjct: 503 S 503
Score = 31.2 bits (69), Expect = 6.8
Identities = 38/165 (23%), Positives = 69/165 (41%), Gaps = 18/165 (10%)
Query: 151 EEESSSSSSDEDEDDRKQIDELLGKVVCVDYISLDKKKALWFPALVVCPDCSDEIAVKKD 210
EE++ ++ E++ D K+ +E K + K+ A+ P ++ KK+
Sbjct: 844 EEKAPATPKTEEKKDSKK-EEAPKKEAPKPKVEEKKEPAVEKPK-------ESKVEAKKE 895
Query: 211 NILVRSFKDGKFTSVPRKDVH---EITSDTAPKPDA-VLKQAFEQALEFHKSRTIPANWK 266
+D K P K+ E+ D PK V K+ + A S+
Sbjct: 896 EA-----EDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEA 950
Query: 267 TELKEDSSSSEAEEEEEEEDDE-KEKEDNSSEEEEEIEPFPEERE 310
K+D+ +A++ EE+ E K KED+ + +E +P E+ E
Sbjct: 951 APEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAE 995
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 79.7 bits (195), Expect = 2e-14
Identities = 125/538 (23%), Positives = 205/538 (38%), Gaps = 86/538 (15%)
Query: 708 QASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNR-----NDLISKEEQNSSSLLEE 762
+AS S +EDS +E+E +K L + ++ S EE + E+
Sbjct: 81 KASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEED 140
Query: 763 NKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKR 822
K KP +K+ + K + S D+D + + K+ K T + K Q K
Sbjct: 141 QKKQPVQKGVKPQAKAAKAPPKKAK--SSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKA 198
Query: 823 GKRRYCNTEECLKTGSPGKKEEKAKN-KESLCMENSSNSSSDEDEEETKAKMTPTK---- 877
+ P + K N K + +SS+SSS +D EE KA TP K
Sbjct: 199 PPK-------------PARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPK 245
Query: 878 KYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKDVWSSI---QGQ 934
K + K+ T S SE + ++ +E Q K++ +SS+
Sbjct: 246 KQVVAKAPVKAATTPTRKSSSSEDS-------SSDEEEEQKKPMKNKPGPYSSVPPPSAP 298
Query: 935 WPKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDS 994
PKK+L PP A E+ ES + + +ES S S E +KPP V S
Sbjct: 299 PPKKSL-----------GTQPPKKAVEKQQPVESSED-SSDESDSSSEEEKKPPTKAVVS 346
Query: 995 KPIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEPL--- 1051
K + + AE S S+S + P P+ T + S + +VT P
Sbjct: 347 KATTKPPPA--KKAAESSSDSSDSDSSEDDEAPSKPAGTT--KNSSNKPAVTTKSPAVKP 402
Query: 1052 --APNQ-----EEVRSIKSETDSTIEVDSVAGELQD----------------LQSEGNSS 1088
AP Q +++ + K+++ S+ E S + E + L +
Sbjct: 403 AAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQA 462
Query: 1089 PAGFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATVVNNKKKGK 1148
P G S S S S+ E E + + + K+ GG++ K + K ++
Sbjct: 463 PQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSS 522
Query: 1149 GTNSSDSEELSAGESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDKDPDLKE 1206
+S + EE G+ + Q K+ T A T GK KN +++ + K+
Sbjct: 523 DDSSEEEEEKLKGKGSPRPQAPKANGTS---------ALTAQNGKAAKNSEEEEEEKK 571
Score = 59.7 bits (143), Expect = 2e-08
Identities = 97/508 (19%), Positives = 174/508 (34%), Gaps = 84/508 (16%)
Query: 456 EDEIERKENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLN 515
ED E +E ++ K + + + +E D DD+ + + +
Sbjct: 88 EDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQ 147
Query: 516 IKVEAEEEKAKSGDETNKEEDEDDEEAEEEEEEEEEEEDEDDDDNNEEEEFECYPPGMKV 575
V+ + + AK+ + K D D + + E+E + ++ + + P
Sbjct: 148 KGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAP 207
Query: 576 QVRYGRGKNQKMYEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIKADKIVRPADKNVPKI 635
++ G+ + +S SD E + + ++V A
Sbjct: 208 KIANGKAASSSSSSSSSSSSDDSEEEKAAATP--------KKTVPKKQVVAKAPVKAATT 259
Query: 636 KHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPE-----------------M 678
RK ++ +++E+ P K S P + P P+ +
Sbjct: 260 PTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPV 319
Query: 679 VSKLDLTDAKNSDTAHIKSIEITSILN------------GLQASESSAEDSEQEDERGAQ 726
S D +D +S + K ++++ +S+SS DS ++DE ++
Sbjct: 320 ESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSK 379
Query: 727 DMDNNGKEESKI----------------------DHLTNNRNDLISKEEQNSSSLLEEN- 763
+K L + D S EE++SSS E+
Sbjct: 380 PAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTK 439
Query: 764 --------KVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTK----KRKDVKKDT 811
K A +S P ++P+ R + EE+E T K+K K
Sbjct: 440 KMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAG 499
Query: 812 TDKSSKP-QIKRGKRRYCNT----------EECLK-TGSPGKKEEKAKNKESLCMENSSN 859
SKP K+GK N+ EE LK GSP + KA +L +N
Sbjct: 500 GAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKA 559
Query: 860 SSSDEDEEETKAKMTPTKKYNGLEEKRK 887
+ + E+EEE K K +G +KRK
Sbjct: 560 AKNSEEEEEEKKKAAVVVSKSGSLKKRK 587
Score = 57.8 bits (138), Expect = 7e-08
Identities = 144/678 (21%), Positives = 229/678 (33%), Gaps = 137/678 (20%)
Query: 546 EEEEEEEEDEDDDDNNEEEEFECYPPGMKVQV---RYGRGKNQKMYEASIKDSDVEGGEV 602
++ +++ D +D++EEEE PP K V R G + +AS S E
Sbjct: 76 KKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESS-- 133
Query: 603 LYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKL 662
D+ + D+ +P K V K K K D D S ++
Sbjct: 134 -------------DDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSED--- 177
Query: 663 RRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDE 722
+PP P V+ T A I NG AS SS+ S +
Sbjct: 178 ----EPPKNQKPKITPVTVKAQTKAPPKPAR-----AAPKIANGKAASSSSSSSSSSSSD 228
Query: 723 RGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERL 782
EE+ +++ ++ +V PV +
Sbjct: 229 ---------------------------DSEEEKAAATPKKTVPKKQVVAKAPVKAATTPT 261
Query: 783 RKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKK 842
RK SED+ +E+E KK K P K+ L T P K
Sbjct: 262 RKSSS--SEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKK-------SLGTQPPKKA 312
Query: 843 EEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVA 902
EK + ES E+SS+ S EEE K PTK V
Sbjct: 313 VEKQQPVES--SEDSSDESDSSSEEE---KKPPTK----------------------AVV 345
Query: 903 EKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSD-----TEAAASPPH 957
K + + ++S D D SS + P K + S+ T++ A P
Sbjct: 346 SKATTKPPPAKKAAESS--SDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPA 403
Query: 958 PAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSN 1017
AP++ V + +S S E S EEKT ++ P + +
Sbjct: 404 AAPKQPVGGGQKLLTRKADSSSSEEE---------SSSSEEEKTKKM--VATTKPKATAK 452
Query: 1018 SVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGE 1077
+ L+ P ++P +GSR SS S+ + +EE ++ KS + VAG
Sbjct: 453 AALSLP--AKQAP------QGSRDSSS--DSDSSSSEEEEEKTSKSAVKK--KPQKVAGG 500
Query: 1078 LQDLQSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRSHK 1137
++ ++S SSSS + E E + G R + + G+S
Sbjct: 501 AAP-SKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTS--------- 550
Query: 1138 ATVVNNKKKGKGTNSSDSEELSAGESITKSQPVKSVSTGMKSHSTKSP----ARTQSPGK 1193
A N K K + + E+ A ++KS +K + ++P + Q+P
Sbjct: 551 ALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNT 610
Query: 1194 CGKNGDKDPDLKEPSNRL 1211
K + P R+
Sbjct: 611 FPKRKKGEKRASSPFRRV 628
Score = 44.3 bits (103), Expect = 8e-04
Identities = 106/514 (20%), Positives = 179/514 (34%), Gaps = 105/514 (20%)
Query: 442 EEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLD 501
EE+ P++ P + ++ K +K + + S + SD+E+E KKP N
Sbjct: 232 EEKAAATPKKTVP-KKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQ--KKPMKN---- 284
Query: 502 DKDDDTTRVDESLNIKVEAEEEKAKSGDETNKEEDEDDEEAEEEEEEEEEEEDEDDDDNN 561
K + V A K G + K+ E+++ E E+ D+ D++
Sbjct: 285 -KPGPYSSVPPP-----SAPPPKKSLGTQPPKKA------VEKQQPVESSEDSSDESDSS 332
Query: 562 EEEEFECYPPGMKVQVRYGRGKN---QKMYEASIKDSDVEGGEVLYLVHYCGWNVRYDEW 618
EEE + P K V K +K E+S SD + E +
Sbjct: 333 SEEEKK---PPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSN 389
Query: 619 IKADKIVRPADKNVPKIKH-----RKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTN 673
A PA K K +K + K D ++E S + K +++
Sbjct: 390 KPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMV-----AT 444
Query: 674 PSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGK 733
P+ +K L+ L QA + S + S D D++
Sbjct: 445 TKPKATAKAALS------------------LPAKQAPQGSRDSSS--------DSDSSSS 478
Query: 734 EESKIDHLTNNRNDLISKEEQNSSSLLEEN--KVHADLVISKPVSKSPERLRKDIEVLSE 791
EE +EE+ S S +++ KV SKP S + S+
Sbjct: 479 EE---------------EEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSD 523
Query: 792 DTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKES 851
D+ EE+E K + S +PQ + T + K ++EE+ K K +
Sbjct: 524 DSSEEEEEKLKGKG---------SPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAA 574
Query: 852 LCMENSSNSSSDEDEEETKAKMTPTKKY------NGLEEKRKSLRTTGFYSGFSEVAEKR 905
+ + S + + E K TP K N +++K + S F V E+
Sbjct: 575 VVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGEKRAS--SPFRRVREEE 632
Query: 906 IKLLNNSDERLQNSRAKDRK-DVWSSIQGQWPKK 938
I++ +SR D D G W ++
Sbjct: 633 IEV---------DSRVADNSFDAKRGAAGDWGER 657
Score = 39.7 bits (91), Expect = 0.019
Identities = 44/171 (25%), Positives = 74/171 (43%), Gaps = 16/171 (9%)
Query: 1128 SSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESITKSQPVKSVST-----GMKSHST 1182
S+K +R +A KK K +SSDSE+ S E + P K + G+
Sbjct: 60 SAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKA 119
Query: 1183 KSPARTQSPGKCGKNGDKDPDLKE--------PSNRLPKVYKWSFQMSDLENMTSAERIT 1234
+ A S + + D + D K+ P + K + SD ++ +S+E
Sbjct: 120 AAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEP 179
Query: 1235 ILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSSSSSPSSSS 1285
K Q+ + +++K++ + + + K AA+SSSSSS SSSS
Sbjct: 180 ---PKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSS 227
Score = 37.4 bits (85), Expect = 0.095
Identities = 62/320 (19%), Positives = 111/320 (34%), Gaps = 61/320 (19%)
Query: 899 SEVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKE---LFSDSDTEAAASP 955
SEVA K K + + S D W + P++ L+ + + +A++S
Sbjct: 28 SEVANKFAKATGATQQDANASSLLDIYSFWLK-SAKVPERKLQANGPVAKKAKKKASSSD 86
Query: 956 PHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSG 1015
+ EE EE +Q +++ P+ + PP + A S
Sbjct: 87 SEDSSEE---EEEVQGPPAKKAAVPAKRVGLPP-----------------GKAAAKASES 126
Query: 1016 SNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVA 1075
S+S ++ E V +G + Q+ + P ++ +S S++DS+ E +
Sbjct: 127 SSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPP-----KKAKSSDSDSDSSSEDEPPK 181
Query: 1076 GELQDLQSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRS 1135
N P +V + + P+P K + SSS
Sbjct: 182 ----------NQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSS------ 225
Query: 1136 HKATVVNNKKKGKGTNSSDSEELSAGESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCG 1195
+S DSEE A + K+ P K V + +P R S +
Sbjct: 226 ---------------SSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSE-D 269
Query: 1196 KNGDKDPDLKEPSNRLPKVY 1215
+ D++ + K+P P Y
Sbjct: 270 SSSDEEEEQKKPMKNKPGPY 289
Score = 35.4 bits (80), Expect = 0.36
Identities = 30/128 (23%), Positives = 52/128 (40%), Gaps = 5/128 (3%)
Query: 428 VKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSK--KNLLESIPTHSDQ 485
V+++ E E +E + E+KP + K KP K ++ +S + S +
Sbjct: 313 VEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSE 372
Query: 486 EKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGDETNKEEDEDDEEAEEE 545
+ E K +N +K TT+ S +K A ++ G + D +EEE
Sbjct: 373 DDEAPSKPAGTTKNSSNKPAVTTK---SPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEE 429
Query: 546 EEEEEEEE 553
EEE+
Sbjct: 430 SSSSEEEK 437
Score = 33.1 bits (74), Expect = 1.8
Identities = 37/162 (22%), Positives = 62/162 (38%), Gaps = 32/162 (19%)
Query: 134 PVIGKKTNRGRRSNHIPEEESSSSSSDEDEDDRKQIDELLGKVVCVDYISLDKKKALWFP 193
PV G + R+++ EE SSSS E+E +K + K +SL K+A
Sbjct: 409 PVGGGQKLLTRKADSSSSEEESSSS--EEEKTKKMVATTKPKATAKAALSLPAKQA---- 462
Query: 194 ALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTAPKPDAVLKQAFEQAL 253
P S + + D+ ++ S +K ++ AP A K+
Sbjct: 463 -----PQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKG----- 512
Query: 254 EFHKSRTIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNS 295
K +SS+S + ++ EE++EK K S
Sbjct: 513 ----------------KAESSNSSSSDDSSEEEEEKLKGKGS 538
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 78.2 bits (191), Expect = 5e-14
Identities = 169/897 (18%), Positives = 305/897 (34%), Gaps = 107/897 (11%)
Query: 446 NIIPREEKPIEDEIERKEN---IKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDD 502
N E++ IE+ + N I P + SK+N +E EV ED LD+
Sbjct: 191 NSTDNEDEIIENSCRNEGNTSEITPQINSKRN--------GTKEAEVTPGTGED-AGLDN 241
Query: 503 KDDDTTRVDESLNIKVEAEEEKAKSGDETNKEEDEDDEEAEEEEEEEEEEEDEDDDDNNE 562
D G + DED++E ++E+EE +D +N++
Sbjct: 242 SD-----------------------GSPSGNGADEDEDEGSGDDEDEEAGNGKDSSNNSK 278
Query: 563 EEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIKAD 622
+E + + G+ + K Y D EG E + V D+ K++
Sbjct: 279 GQEGQDHGKEDDHDSSIGQNSDSKEY------YDPEGKEDPHN------EVDGDKTSKSE 326
Query: 623 KIVR--PAD------KNVPKIKHR--KKIKNKLDKE---------KDKDEKYSPKNCKLR 663
+ P D ++ K+ HR K+++N++ KE +DK + + R
Sbjct: 327 ENSAGIPEDNGSQRIEDTQKLNHRESKRVENRITKESETHAVGKSQDKGIEIKGPSSGNR 386
Query: 664 RLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEI------------TSILNGLQASE 711
++K + N E + + K + + + I N S
Sbjct: 387 NITKEVGKGNEGKEDKGQHGMILGKGNVKTQGEVVNIEGPGQKSEPGNKVGHSNTGSDSN 446
Query: 712 SSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVI 771
S DS D++ Q D N +ES + N+ +D S ++S +E+K + +
Sbjct: 447 SDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSD 506
Query: 772 SKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDV---KKDTTDKSSKPQIKRGKRRYC 828
SK D + + + D K D++D S
Sbjct: 507 SKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDS 566
Query: 829 NTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKS 888
+ + + S + + +SS+SS+ D ++ + + + K S
Sbjct: 567 SDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDS 626
Query: 889 LRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSD 948
++ S S+ K +NS + NS + D + +S + S SD
Sbjct: 627 SKSE---SDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSS-DSSDSSDSSSSSD 682
Query: 949 TEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRK 1008
+ ++ + +E S + + + S S + + DS + + N
Sbjct: 683 SSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSD 742
Query: 1009 AEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDST 1068
+ S SNS + S SS + SS + + N + + +DS+
Sbjct: 743 SSDSSDSSNS-------SDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSS 795
Query: 1069 IEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSS 1128
DS S+ + S D+ S+SS + + + + + GS
Sbjct: 796 ---DSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSD 852
Query: 1129 SKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESITKSQPVKSVSTGMKSHSTKSPART 1188
S RS + ++ +NSSDS + S + S S S S+ S +
Sbjct: 853 SDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSS 912
Query: 1189 QSPGKCGKNGDKDPDLKEPSNRLPKVYKWSFQMSDLENMTSAERITILQEKLQEIRKHYL 1248
S + D E SN + SD N + + +
Sbjct: 913 DS-----SDSSNSSDSSESSNSSD-----NSNSSDSSNSSDSSDSSDSSNSSDSSNSSDS 962
Query: 1249 SLKSEVASIDRRRKRLKKKERESAATSSSSSSPSSSSITAAVMLTLAEPSMSSASQN 1305
S S+ S D S ++ SS SS SS S ++ ++ S SS S N
Sbjct: 963 SNSSD--SSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSN 1017
Score = 74.3 bits (181), Expect = 7e-13
Identities = 161/900 (17%), Positives = 316/900 (35%), Gaps = 109/900 (12%)
Query: 430 EENETEIKEI----KMEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLESIPTHSDQ 485
EEN I E ++E+ + + RE K +E+ I KE+ ++G ++ I S
Sbjct: 326 EENSAGIPEDNGSQRIEDTQKLNHRESKRVENRIT-KESETHAVGKSQDKGIEIKGPSSG 384
Query: 486 EKEVNIKKPEDNENLDDKDD--------DTTRVDESLNIKVEAEEEK-------AKSGDE 530
+ + + + NE +DK + E +NI+ ++ + + +G +
Sbjct: 385 NRNITKEVGKGNEGKEDKGQHGMILGKGNVKTQGEVVNIEGPGQKSEPGNKVGHSNTGSD 444
Query: 531 TNKEE----DEDDEEAEEEEEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQK 586
+N + D DD+ + ++ +E + +DD N+E + R N
Sbjct: 445 SNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSESDN--------NSSSRGDASYNSD 496
Query: 587 MYEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLD 646
+ + SD +G E D+ + +D N N +
Sbjct: 497 ESKDNGNGSDSKGAE--------------DDDSDSTSDTNNSDSN----------GNGNN 532
Query: 647 KEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNG 706
D D+ S K K D +D+ +SD+++ +S +
Sbjct: 533 GNDDNDKSDSGKG---------------------KSDSSDSDSSDSSNSSDSSDSSDSDS 571
Query: 707 LQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVH 766
++ SS DS D + D D++ S +++ +D S +S S + +K
Sbjct: 572 SDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDS-SDSSDSSDSKSDSSKSE 630
Query: 767 ADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRR 826
+D S S S + D S+ +D + D D++D SS
Sbjct: 631 SDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSD-SSDSSDSSSSSDSSNSSDS 689
Query: 827 YCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKR 886
+++ S + + +S +SSNS+S + + + + + + +
Sbjct: 690 SDSSDS--SNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSS 747
Query: 887 KSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSD 946
S + S S+ ++ +NS + +S + D D +S + SD
Sbjct: 748 DSSNS----SDSSDSSDS-----SNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDS--SD 796
Query: 947 SDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKTVEVND 1006
S + +S + + + +S + + + S S + DS + + +
Sbjct: 797 SSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSS 856
Query: 1007 RKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETD 1066
+++ +S +S + + +S S E S S S + + + +D
Sbjct: 857 NRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSD 916
Query: 1067 STIEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSNQPEPEH-PEKACTGQKRVKDAQGG 1125
S+ DS S + S D+S SS SSN + + + + + ++
Sbjct: 917 SSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDS 976
Query: 1126 GSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESITKSQPVKSVSTGMKSHSTKSP 1185
SS S + ++ +NSSDS + S + S S S+ S S
Sbjct: 977 SDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNS----SDSSNSSDSSNSSD 1032
Query: 1186 ARTQSPGKCGKNGDKDPDLKEPSNRLPKVYKWSFQMSDLENMTSAERITILQEKLQEIRK 1245
+ S + D + SN S SD + + + + + +
Sbjct: 1033 SSDSSDSSDSSDSSDSSDSSDSSNSSD-----SSDSSDSSDSSDSSDSSDSSDSSE---- 1083
Query: 1246 HYLSLKSEVASIDRRRKRLKKKERESAATSSSSSSPSSSSITAAVMLTLAEPSMSSASQN 1305
S S +S S ++ SS SS SS S ++ ++ S SS S N
Sbjct: 1084 ---SSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSN 1140
Score = 68.6 bits (166), Expect = 4e-11
Identities = 114/728 (15%), Positives = 232/728 (31%), Gaps = 50/728 (6%)
Query: 474 NLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGDETNK 533
N +S + + N D+ + D D + +S N ++ + +++
Sbjct: 559 NSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSD 618
Query: 534 EEDEDDEEAEEEEEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEASIK 593
D + ++ E + + + D D+N + + N ++S
Sbjct: 619 SSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSD----------------NSDSSDSSNS 662
Query: 594 DSDVEGGEVLYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDE 653
+ + + + D +D +D + + D D
Sbjct: 663 SNSSDSSDS---------SDSSDSSSSSDSS-NSSDSSDSSDSSNSSESSDSSDSSDSDS 712
Query: 654 KYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESS 713
S + ++ S + + D +D+ SD+++ +S + S S
Sbjct: 713 SDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDS--SDSSNSSDSSDSSDSSNSSDSSDS 770
Query: 714 AEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISK 773
++ S+ D + D +++ D ++ + S +S S ++ +D S
Sbjct: 771 SDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSD---SS 827
Query: 774 PVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEEC 833
S S + S D+ D + R D + S +
Sbjct: 828 NSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNE 887
Query: 834 LKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTG 893
S + + +S NSS+SS + ++ + N + S +
Sbjct: 888 SSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDS 947
Query: 894 FYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAA 953
S S + N+SD +S + D D +S SDS + +
Sbjct: 948 SDSSNSSDSSNSSDSSNSSDS--SDSNSSDSSDSSNS--------------SDSSDSSDS 991
Query: 954 SPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPS 1013
S + + + +S + +S + S N + + +D S
Sbjct: 992 SDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDS 1051
Query: 1014 SGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDS 1073
S S++ ++ ++ S SS + SS + + N + +DS+ DS
Sbjct: 1052 SDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDS 1111
Query: 1074 VAGELQDLQSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQK 1133
S + S D+S SS SSN + ++ + D+ SS
Sbjct: 1112 SDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSES-SDSSDSSDSSDSSDSSDSSD 1170
Query: 1134 RSHKATVVNNKKKGKGTNSSDSEELSAGESITKSQPVKSVSTGMKSHSTKSPARTQSPGK 1193
S + N+ ++SSDS + S +S S S + S S+ S + S
Sbjct: 1171 SSDSSDSSNSSDSSDSSDSSDSSDSS--DSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDS 1228
Query: 1194 CGKNGDKD 1201
N D
Sbjct: 1229 SDSNESSD 1236
Score = 67.0 bits (162), Expect = 1e-10
Identities = 117/705 (16%), Positives = 228/705 (32%), Gaps = 47/705 (6%)
Query: 477 ESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGDETNKEED 536
ES + SD + + + D+ + D D + + S + + + S D +N +
Sbjct: 630 ESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDS 689
Query: 537 EDDEEAEEEEEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSD 596
D ++ E + + D D ++ + N S SD
Sbjct: 690 SDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSD-------SSNSSDSSDSSNSSD 742
Query: 597 VEGGEVLYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYS 656
D +D N + D D S
Sbjct: 743 SSDSS--------------DSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDS 788
Query: 657 PKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAED 716
+ S +N S D +D+ +SD+++ +S + S +S++
Sbjct: 789 SNSSDSSDSSNSSDSSNSSDSS----DSSDSSDSDSSNSSD---SSNSSDSSDSSNSSDS 841
Query: 717 SEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVS 776
S+ D D D++ + +S +++ +D + + + SS E+ +D S S
Sbjct: 842 SDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSD---SSDSS 898
Query: 777 KSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKT 836
S + D S+ +D + + + ++ S +
Sbjct: 899 NSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSN 958
Query: 837 GSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYS 896
S + + S +SSNSS D ++ + N + S + S
Sbjct: 959 SSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNS 1018
Query: 897 GFSEVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPP 956
S + ++SD +S + D D SS + SDS + +S
Sbjct: 1019 SDSSNSSDSSNSSDSSDSS-DSSDSSDSSD--SSDSSDSSNSSDSSDSSDSSDSSDSSDS 1075
Query: 957 HPAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGS 1016
+ + + +S + +S S + + + +D SS S
Sbjct: 1076 SDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDS 1135
Query: 1017 NSVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAG 1076
+ N+ ++ S SS + SS + + + + + +DS+ DS
Sbjct: 1136 SDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDS--S 1193
Query: 1077 ELQDLQSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRSH 1136
+ D +SS + D+S SS SS+ + D+ SS S
Sbjct: 1194 DSSDSSDSSDSSDSS-DSSDSSDSSDSSDSSDS----------SDSSDSNESSDSSDSSD 1242
Query: 1137 KATVVNNKKKGKGTNSSDSEELSAGESITKSQPVKSVSTGMKSHS 1181
+ N+ ++SSDS S ES ++S+ + G S S
Sbjct: 1243 SSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDS 1287
Score = 63.9 bits (154), Expect = 1e-09
Identities = 109/731 (14%), Positives = 219/731 (29%), Gaps = 52/731 (7%)
Query: 483 SDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGDETNKEEDEDDEEA 542
SD + D+ + D D + +S + ++ + +KS + D D
Sbjct: 596 SDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSD 655
Query: 543 EEEEEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGGEV 602
+ D D ++ + N S SD + +
Sbjct: 656 SSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDS 715
Query: 603 LYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKL 662
+D + N D D S +
Sbjct: 716 -----------------SDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSD- 757
Query: 663 RRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDE 722
S ++ S + D +D+ NS ++ S +S+SS + +
Sbjct: 758 ---SSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSS----------NSSDSSDSSNSSDSS 804
Query: 723 RGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERL 782
+ D++ +S + +++ N S + NSS +D S S S
Sbjct: 805 NSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSD-------SSDSSDSSDGSDSDSSN 857
Query: 783 RKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKK 842
R D S+ +D + + D +S ++ + +
Sbjct: 858 RSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDS 917
Query: 843 EEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVA 902
+ + ES ++SNSS + ++ + + S + S S+ +
Sbjct: 918 SNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSS 977
Query: 903 EKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPEE 962
+ +NS + +S + D D S + SDS + +S + +
Sbjct: 978 DS-----SNSSDSSDSSDSSDSSDSSDSSNSSDSSDS-----SDSSDSSNSSDSSNSSDS 1027
Query: 963 GVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVLNT 1022
+ +S + +S S + N + + +D SS S+ ++
Sbjct: 1028 SNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDS 1087
Query: 1023 PPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQDLQ 1082
++ S SS + SS + + + +DS+ DS
Sbjct: 1088 SDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDS 1147
Query: 1083 SEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATVVN 1142
SE + S D+S SS SS+ + + D+ SS S + +
Sbjct: 1148 SESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNS----SDSSDSSDSSDSSDSSDSSDSSD 1203
Query: 1143 NKKKGKGTNSSDSEELSAGESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDKDP 1202
+ ++SSDS + S + S S S + + + + D
Sbjct: 1204 SSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTS 1263
Query: 1203 DLKEPSNRLPK 1213
D + S+ K
Sbjct: 1264 DSNDESDSQSK 1274
Score = 56.2 bits (134), Expect = 2e-07
Identities = 97/647 (14%), Positives = 206/647 (31%), Gaps = 37/647 (5%)
Query: 464 NIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEE 523
N S S + S + S + + D+ N + D D++ +S + ++
Sbjct: 685 NSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSS 744
Query: 524 KAKSGDETNKEEDEDDEEAEEEEEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGK 583
+ ++ D D + + + D D N+ +
Sbjct: 745 DSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSS 804
Query: 584 NQKMYEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKN 643
N S SD + + + + +D +D + +R N
Sbjct: 805 NSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSS-DSSDGSDSDSSNRSDSSN 863
Query: 644 KLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSI 703
D D S S +N S D +++ +SD++
Sbjct: 864 SSDSSDSSDSSNSSD-------SSDSSDSNESSNSSDSSDSSNSSDSDSS---------- 906
Query: 704 LNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEEN 763
+ +S+SS + + + DN+ +S +++ +D + + ++SS +
Sbjct: 907 -DSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNS 965
Query: 764 KVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRG 823
+D S S D S+ +D + + D D++D S+
Sbjct: 966 SDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSD-SSDSSDSSNSSDSSNS 1024
Query: 824 KRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLE 883
N+ + + + + + +S NSS+SS D ++ + + E
Sbjct: 1025 SDS-SNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSE 1083
Query: 884 EKRKSLRTTGFYSGFSEVAEKRIKLLNNSD--ERLQNSRAKDRKDVWSSIQGQWPKKTLK 941
S + S S + ++SD + +S + D D S
Sbjct: 1084 SSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDS----------- 1132
Query: 942 ELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKT 1001
SDS + +S + E + +S + +S S + N +
Sbjct: 1133 ---SDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDS 1189
Query: 1002 VEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSI 1061
+ +D SS S+ ++ ++ S SS + S+ + + + + +
Sbjct: 1190 SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNS 1249
Query: 1062 KSETDSTIEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSNQPEPEH 1108
+DS+ DS + + S+ S + S S S S + H
Sbjct: 1250 SDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSNH 1296
>gi|47078224 AT rich interactive domain 5A [Homo sapiens]
Length = 594
Score = 77.0 bits (188), Expect = 1e-13
Identities = 53/157 (33%), Positives = 79/157 (50%), Gaps = 8/157 (5%)
Query: 289 KEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVH 348
++ + E EEE E EE + FL LYKFM++R TPI + P LG++ +NL+K+++ V
Sbjct: 40 EDSPEAGGEREEEQER--EEEQAFLVSLYKFMKERHTPIERVPHLGFKQINLWKIYKAVE 97
Query: 349 KLGGFDNIESGAVWKQVYQDL-GIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQMA 407
KLG ++ + +WK VY +L G P SAA C + Y Y R E
Sbjct: 98 KLGAYELVTGRRLWKNVYDELGGSPGSTSAA----TCTRRHYERLVLPYVRHLKGEDDKP 153
Query: 408 LPEKVVNKQCKEC-ENVKEIKVKEENETEIKEIKMEE 443
LP KQ K EN + E + +E +M++
Sbjct: 154 LPTSKPRKQYKMAKENRGDDGATERPKKAKEERRMDQ 190
>gi|5453638 AT rich interactive domain 3B [Homo sapiens]
Length = 560
Score = 76.3 bits (186), Expect = 2e-13
Identities = 36/103 (34%), Positives = 64/103 (62%), Gaps = 2/103 (1%)
Query: 308 ERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQ 367
ER+ FL L+ FM+ RGTPIN+ P++ + L+L+ L++LV + GG I + +W+++ +
Sbjct: 217 ERKEFLDDLFVFMQKRGTPINRIPIMAKQILDLYMLYKLVTEKGGLVEIINKKIWREITK 276
Query: 368 DLGIPVLNSAAGYNVKCAYKKYLYGF--EEYCRSANIEFQMAL 408
L +P ++A + ++ Y KYLY + E+ S+ E Q A+
Sbjct: 277 GLNLPTSITSAAFTLRTQYMKYLYAYECEKKALSSPAELQAAI 319
>gi|87299628 biorientation of chromosomes in cell division 1-like
[Homo sapiens]
Length = 3051
Score = 75.5 bits (184), Expect = 3e-13
Identities = 168/840 (20%), Positives = 328/840 (39%), Gaps = 156/840 (18%)
Query: 436 IKEIK-MEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLESIPTHSDQEKEV----- 489
++EIK +E N + K ++ E ++N G KK ++KE
Sbjct: 287 VEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKF 346
Query: 490 -NIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGDETNKE-------------- 534
+ KK ED + + D+ + ESL + E KAK+ + T ++
Sbjct: 347 DHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGLTDI 406
Query: 535 -------------EDEDDEEAEEEEEEEEEEEDEDDDDNNEEEEFECY----PPGMKVQV 577
E++ +EE + EE E DD++ N++ + + G V
Sbjct: 407 TVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSV 466
Query: 578 RYGRGKNQKMYEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKH 637
R+ +Y DSD E V +++ K K
Sbjct: 467 RHAYVHKPYLYSKYYSDSDDE------------------------LTVEQRRQSIAKEKE 502
Query: 638 RKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKS 697
+ ++ ++++EK ++++ + + + SK Q S ++ + ++ + K+
Sbjct: 503 ERLLRRQINREKLEEKR--KQKAEKTKSSKTKGQGRSSVDL-------EESSTKSLEPKA 553
Query: 698 IEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISK---EEQ 754
I +L + E S++ ++ +++++ N K++ + + +++ L + E++
Sbjct: 554 ARIKEVLKERKVLEKKVALSKKR-KKDSRNVEENSKKKQQYEE--DSKETLKTSEHCEKE 610
Query: 755 NSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRK--------D 806
SS E VHA SKP RL + + V+ E+ + + E KR+
Sbjct: 611 KISSSKELKHVHAKSEPSKPA----RRLSESLHVVDENKNESKLEREHKRRTSTPVIMEG 666
Query: 807 VKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKES------LCMENSSNS 860
V+++T + K Q++R + C TEE K S K E+ K +S ++ S
Sbjct: 667 VQEETDTRDVKRQVERSE--IC-TEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKS 723
Query: 861 SSDEDEEE---TKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQ 917
S ++ E E ++ K++ KY G + K+ T +S +EK +K+ N ++ Q
Sbjct: 724 SKEKPEREKTPSEDKLSVKHKYKG-DCMHKTGDETELHS-----SEKGLKVEENIQKQSQ 777
Query: 918 NS----------RAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPEEGVAEE 967
+ ++K R + S+ G+ K + + T+ + E ++ E
Sbjct: 778 QTKLSSDDKTERKSKHRNERKLSVLGKDGKPVSEYIIK---TDENVRKENNKKERRLSAE 834
Query: 968 SLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTP 1027
+T AE +S S + DS ++ + + R++E S + +T +
Sbjct: 835 --KTKAEHKSRRSS-----DSKIQKDSLGSKQHGITL-QRRSESYSEDKCDMDSTNMDSN 886
Query: 1028 ESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGNS 1087
P V E R +S + ++ V KS+T +V V ELQ+ ++ +
Sbjct: 887 LKPEEVVHKEKRRTKSLL--------EEKLVLKSKSKTQGK-QVKVVETELQEGATKQAT 937
Query: 1088 SPAGFDASVSSSSSNQPEPEHPEKA------CTGQKRVKDAQGGGSSSKKQKRSHKATVV 1141
+P ++ N E + K TG + V + + S ++ SH+A +
Sbjct: 938 TPK--PDKEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKDSSHRAKLP 995
Query: 1142 NNKKKGKGTNSSDSEELSAGESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDKD 1201
K+K K S S L + +S G KS S K ++ K+ DKD
Sbjct: 996 LAKEKYKSDKDSTSTRLE-----------RKLSDGHKSRSLKHSSKDIKKKDENKSDDKD 1044
Score = 65.5 bits (158), Expect = 3e-10
Identities = 173/897 (19%), Positives = 332/897 (37%), Gaps = 152/897 (16%)
Query: 400 ANIEFQMALPEKVVNKQCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEI 459
++++ + + + + K + E +KE KV E+ K+ K ++ RN+ +K + E
Sbjct: 537 SSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRK-KDSRNVEENSKKKQQYEE 595
Query: 460 ERKENIKPSLGSKKNLLESIP----THSDQEKEVNIKKPEDNENLDDKDDDTTRVDE--- 512
+ KE +K S +K + S H+ E ++ ++ ++ D++ + ++++
Sbjct: 596 DSKETLKTSEHCEKEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHK 655
Query: 513 ---SLNIKVEAEEEKAKSGDETNKEEDEDDEEAEEEEEEEEEEEDEDDDDNNEEEEFECY 569
S + +E +E+ + D K + E E EE ++++ + ++ E
Sbjct: 656 RRTSTPVIMEGVQEETDTRDV--KRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHL 713
Query: 570 PPGMKVQVRYGRGKNQKMYEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIKADKIVRPAD 629
+K +V+ + K ++ S V+ +H G K K+ +
Sbjct: 714 KSLLKKEVKSSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELHSSEKGLKV----E 769
Query: 630 KNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLT---- 685
+N+ K + K+ + DK E+ S K+ R+LS P E + K D
Sbjct: 770 ENIQKQSQQTKLSSD-----DKTERKS-KHRNERKLSVLGKDGKPVSEYIIKTDENVRKE 823
Query: 686 -----------------DAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDM 728
++ S + I+ + S +G+ S SE + + + +M
Sbjct: 824 NNKKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDMDSTNM 883
Query: 729 DNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVH-------------ADLVISKPV 775
D+N K E +++ KE++ + SLLEE V + + +
Sbjct: 884 DSNLKPE-----------EVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVETELQEGA 932
Query: 776 SKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDT-----------------TDKSSKP 818
+K + D E +E+ D E+ +K ++T D S +
Sbjct: 933 TKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKDSSHRA 992
Query: 819 QIKRGKRRYCNTEECLKTG-----SPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKM 873
++ K +Y + ++ T S G K K+ + N S D+D +E +
Sbjct: 993 KLPLAKEKYKSDKDSTSTRLERKLSDGHKSRSLKHSSKDIKKKDENKSDDKDGKEVDSSH 1052
Query: 874 TPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQG 933
+ + L EK+ S R + E R L+ + + A + S
Sbjct: 1053 EKARGNSSLMEKKLSRR----------LCENRRGSLSQEMAKGEEKLAANTLSTPSGSSL 1102
Query: 934 QWPKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNVD 993
Q PKK+ D P P E +E ++ V E + ++D
Sbjct: 1103 QRPKKS-------GDMTLI---PEQEPMEIDSEPGVENVFEVSKTQDN--RNNNSQQDID 1150
Query: 994 SKPIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSV------------TVTEGSRQ 1041
S+ +++KT +K E + ++S P P + V T+T+
Sbjct: 1151 SENMKQKT-SATVQKDELRTCTADSKATAPAYKPGRGTGVNSNSEKHADHRSTLTKKMHI 1209
Query: 1042 QSSVT-----VSEPLAPNQEEVRSIKSET------DSTIEVDSVAGELQDLQSEGNSSPA 1090
QS+V+ EP+ EV +I SET + E D V L++ +E + +
Sbjct: 1210 QSAVSKMNPGEKEPIHRGTTEV-NIDSETVHRMLLSAPSENDRVQKNLKNTAAEEHVAQG 1268
Query: 1091 GFDASVSSSSSNQP-----------EPEHPEKACTGQKRVKDAQGGGSSSKKQKRSHKAT 1139
S++ + P E P+ KR +G +S+ S
Sbjct: 1269 DATLEHSTNLDSSPSLSSVTVVPLRESYDPDVIPLFDKRTV-LEGSTASTSPADHSALPN 1327
Query: 1140 VVNNKKKGKGTNSSDSEELSAGESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCGK 1196
++ + +SDS+E GE T P K+ T K H ++ T GK GK
Sbjct: 1328 QSLTVRESEVLKTSDSKE--GGEGFTVDTPAKASITS-KRHIPEAHQATLLDGKQGK 1381
Score = 41.6 bits (96), Expect = 0.005
Identities = 63/335 (18%), Positives = 129/335 (38%), Gaps = 52/335 (15%)
Query: 400 ANIEFQMALPEKVVNKQCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEI 459
A ++ + L + +N + +EI + N+ EI + + I + E+
Sbjct: 2702 AELQREPLLVNESLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAISGHSVEADPKEV 2761
Query: 460 ERKENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVE 519
E +E P K++ L S D ++ + + + T+ + S ++
Sbjct: 2762 EEEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKEENSRDL--- 2818
Query: 520 AEEEKAKSGDETNKE-----EDEDDEEAEEEEEEEEEEEDEDDDDNNEEEEFECYPPGMK 574
EE K+ ETN E++D+ + E E+ E+ D+D + EE++
Sbjct: 2819 --EELPKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQ--------P 2868
Query: 575 VQVRYGRGKNQKM-YEASIK---DSDVEGGEVLYLVHYCGWNVRYDEWIKADKIVRPADK 630
+ ++ RG+ +K E ++K DS + G V V K+++ +
Sbjct: 2869 IIIKRKRGRPRKYPVETTLKMKDDSKTDTGIV---------TVEQSPSSSKLKVMQTDES 2919
Query: 631 NVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLT---DA 687
N K+ N ++ D+ +RR + P K LT DA
Sbjct: 2920 N-------KETANLQERSISNDDGEEKIVTSVRRRGRKP-----------KRSLTVSDDA 2961
Query: 688 KNSDTAHIKSIEITSILNGLQASESSAEDSEQEDE 722
++S+ + ++ + + ES E+ E+E++
Sbjct: 2962 ESSEPERKRQKSVSDPVEDKKEQESDEEEEEEEED 2996
Score = 41.2 bits (95), Expect = 0.007
Identities = 53/298 (17%), Positives = 123/298 (41%), Gaps = 43/298 (14%)
Query: 584 NQKMYEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKN 643
N++++ S ++ G G +V D K V ++++PK RK+ ++
Sbjct: 2725 NEEIHSESYNKGEISSGRKDNAEAISGHSVEADP-----KEVEEEERHMPK---RKRKQH 2776
Query: 644 KLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSI 703
L E + D+ + ++ + +T P D K ++ ++ + TS
Sbjct: 2777 YLSSEDEPDDNPDVLDSRIETAQRQCPETEPH----------DTKEENSRDLEELPKTSS 2826
Query: 704 LNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRND--LISKEE-------- 753
+ + +++ E++DE + + E++ D + + D +I K +
Sbjct: 2827 ----ETNSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKYP 2882
Query: 754 -QNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTT 812
+ + + +++K +V V +SP + ++V+ D +E ++R D
Sbjct: 2883 VETTLKMKDDSKTDTGIVT---VEQSPSSSK--LKVMQTDESNKETANLQERSISNDDGE 2937
Query: 813 DKSSKPQIKRGKR--RYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEE 868
+K +RG++ R + ++ P +K +K+ + +E+ SDE+EEE
Sbjct: 2938 EKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDP---VEDKKEQESDEEEEE 2992
Score = 40.4 bits (93), Expect = 0.011
Identities = 44/201 (21%), Positives = 91/201 (45%), Gaps = 43/201 (21%)
Query: 430 EENETEIKEIKMEEERNIIPRE-----EKPIEDEIERKENIKPSLG-------SKKNLLE 477
E+N+ + + + E++ II R+ + P+E ++ K++ K G + L+
Sbjct: 2853 EQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLK 2912
Query: 478 SIPTHSDQEKEVNIKKPE-DNENLDDKDDDTTR------------VDESLNIKVEAEEEK 524
+ T ++ N+++ N++ ++K + R D++ + + E + +K
Sbjct: 2913 VMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQK 2972
Query: 525 AKSGDETNKEEDEDDEEAEEEEEEE------------EEEEDEDDDDNNEEEEFECYPPG 572
+ S +K+E E DEE EEEEE+E E + + + + + E PPG
Sbjct: 2973 SVSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLSPSIKRKREVSPPG 3032
Query: 573 MKVQVRYGRGKNQKMYEASIK 593
+ RG+ Q++ EA +K
Sbjct: 3033 ART-----RGQ-QRVEEAPVK 3047
Score = 31.2 bits (69), Expect = 6.8
Identities = 15/42 (35%), Positives = 25/42 (59%), Gaps = 6/42 (14%)
Query: 269 LKEDSSSSEAEEEEEE------EDDEKEKEDNSSEEEEEIEP 304
+ +D+ SSE E + ++ ED ++++ D EEEEE EP
Sbjct: 2957 VSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEP 2998
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 75.1 bits (183), Expect = 4e-13
Identities = 218/1134 (19%), Positives = 413/1134 (36%), Gaps = 172/1134 (15%)
Query: 208 KKDNILVRSFKDGKFTSVPRKDVHEITSDTAPKPDAVLKQAFEQALEFHKSRTIPANWKT 267
K+ N D KF + RK + + K + +Q H + +P +
Sbjct: 387 KEKNTKEHKVIDAKFETKARKGEKPCALEKKDISKSEAKLSRKQVDSEHMHQNVPTEEQR 446
Query: 268 ELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEE-RENFLQQLYKFME----- 321
K S+ E ++ + +E+ + E + S + + +I P E+ + L ME
Sbjct: 447 TNK--STGGEHKKSDRKEEPQYEPANTSEDLDMDIVSVPSSVPEDIFENLETAMEVQSSV 504
Query: 322 ----DRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSA 377
D + + LN+ GG + + V K++Y L L+++
Sbjct: 505 DHQGDGSSGTEQEVESSSVKLNISSK----DNRGGIKSKTTAKVTKELYVKLTPVSLSNS 560
Query: 378 AGYNVKCAYKKYLYGFEEYCRSANIEFQMALPEKVVNKQCKECENVKEIKVKEENETEIK 437
C Q +K K C +++ + +EN
Sbjct: 561 PIKGADC--------------------QEVPQDKDGYKSCGLNPKLEKCGLGQENSDN-- 598
Query: 438 EIKMEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDN 497
E +E E +++ E ++ R +K + + + ++SD+E +K+ +
Sbjct: 599 EHLVENEVSLLLEES-----DLRRSPRVKTTPLRRPTETNPVTSNSDEECNETVKEKQKL 653
Query: 498 ENLDDKDDDTTRVDESLNIKVEAEEEKAKSGDETNKEEDEDDEEAEEEEEEEEEEEDEDD 557
K D D +++ + K+K + ++ D D+ A +E D
Sbjct: 654 SVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSD 713
Query: 558 DDNNEEEEFECYPPGMKVQV-RYGRGKNQKMYEASIKDSDVEGGEVLYLV-------HYC 609
D NE +K Q + +GK ++ S D D + G+
Sbjct: 714 TDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQ 773
Query: 610 GWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPP 669
+ YD + +K ++ K +K+I N D + +DEK+S K
Sbjct: 774 SESSNYDS--ELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKG---------- 821
Query: 670 FQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMD 729
+D KN T + E S++D+E++ ER +
Sbjct: 822 ------------MDNQGHKNLKT----------------SQEGSSDDAERKQER-----E 848
Query: 730 NNGKEESKIDHLTN--NRNDLISKEEQNSSSLLEENKVHA--DLVISKPVSKSPERLRKD 785
E +D T D + K++Q S+S +K+ S V K E K
Sbjct: 849 TFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKS 908
Query: 786 IEVLSEDTDYEEDEVTK-KRKDVKKDTTDKSS---KPQIKRG----------KRRYCNTE 831
+ ++ +D ++ K +KKD +D++S K Q K+G K++ E
Sbjct: 909 KHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKME 968
Query: 832 ECLKTGSPGKKEEKAKNKESLC-----MENSSNSSSDEDEEETKAKMTPTKKYNGLEEKR 886
+ ++ S G EK +E +C ++ N ++D +++ K + +KK + L
Sbjct: 969 QQYESSSDG--TEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDEL---- 1022
Query: 887 KSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSD 946
S ++E + + ++S+++ + A R+ + G+ +K ++ S
Sbjct: 1023 ---------SDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRK--RQDCSS 1071
Query: 947 SDTEAAASPPHPAPEEGV--AEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKTVEV 1004
SDTE + E+G +++ L+ + E + S + + S E++ E
Sbjct: 1072 SDTE-----KYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSED 1126
Query: 1005 NDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSE 1064
N +K + SS +V+ E + T R+Q+ +T S ++ SI
Sbjct: 1127 NKKKKQRTSSKKKAVI-----VKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEG 1181
Query: 1065 TDSTIEVDSVAGELQDLQSEGNSSPAGFDA---SVSSSSSNQPEPEHPEKACTGQKRVKD 1121
+ ++ V L G +G +A SV + + + PE + +++
Sbjct: 1182 SSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEE 1241
Query: 1122 AQGGGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESITKSQPVKSVSTGMKSHS 1181
+ SS + + ++GK +EE + G+ K+Q V S S S
Sbjct: 1242 IKANLSSDEDGSSD------DEPEEGKKRTGKQNEE-NPGDEEAKNQ-VNSESDSDSEES 1293
Query: 1182 TKSPAR--------TQSPGKCGKNGDKDP-DLKEPSNR-LPKVYKWSFQMSDLENMTSAE 1231
K R T S G+ G+ P + KE R KV + SD + +E
Sbjct: 1294 KKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSE 1353
Query: 1232 RITILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSSSSSPSSSS 1285
++ E E R S K ++R + KKK R SSS S+S
Sbjct: 1354 EVS---ESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNS 1404
Score = 60.5 bits (145), Expect = 1e-08
Identities = 41/125 (32%), Positives = 69/125 (55%), Gaps = 12/125 (9%)
Query: 443 EERNIIPREEKPIEDEIERKENIKPSLGS---KKNLLESIPTHSDQEKEV--NIKKPEDN 497
EE+ P+E K ++ RK + + S S + + E + D+++ + KK E
Sbjct: 1316 EEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELE 1375
Query: 498 ENLDDKDDDTTRVDESLNIKVEAEEEKAKSGDETNKEEDEDDEEAEEEEEEEEEEEDEDD 557
EN R IKV+ E + S +++N EE+E+++E EEEEEEEEEEE+ED+
Sbjct: 1376 ENQRSYKQKKKR----RRIKVQ---EDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDE 1428
Query: 558 DDNNE 562
+D+++
Sbjct: 1429 NDDSK 1433
Score = 58.9 bits (141), Expect = 3e-08
Identities = 113/580 (19%), Positives = 211/580 (36%), Gaps = 113/580 (19%)
Query: 386 YKKYLYGFEEYCRSANIEFQMALPEKVVNKQCKECENVKEIKVKEENETEIKEIKMEEER 445
+KK + E+ S++ + LPE+ + C + +K+IK N T E K ++ R
Sbjct: 960 FKKKVIKMEQQYESSS-DGTEKLPER--EEICHFPKGIKQIK----NGTTDGEKKSKKIR 1012
Query: 446 NIIPREEKPIEDEIERKENIKPSLGSKKNLLESIPTHSDQEKEVNIK----------KPE 495
+ +++ + D E+ S S ++ + ++K +
Sbjct: 1013 DKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSS 1072
Query: 496 DNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGDETNKEEDEDDEEAEEEEEEEEEEEDE 555
D E K+D D+ L ++E E + S KE ++ EE E+ ++ +
Sbjct: 1073 DTEKYSMKEDGCNSSDKRLK-RIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKK 1131
Query: 556 DDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEASI---KDSDVEGGEVLYLVHYCGWN 612
+ ++ +K + R + K +A I SD+E +
Sbjct: 1132 QRTSSKKKAVI------VKEKKRNSLRTSTKRKQADITSSSSSDIEDDD----------- 1174
Query: 613 VRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQT 672
+N + + ++K P L S F
Sbjct: 1175 -----------------------------QNSIGEGSSDEQKIKPVTENLVLSSHTGFCQ 1205
Query: 673 NPSPEMVSK-LDLT-DAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDE-------R 723
+ E +SK + +T D + D I +L ++A+ SS ED +DE
Sbjct: 1206 SSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRT 1265
Query: 724 GAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVIS----------K 773
G Q+ +N G EE+K + N+ +D S E++ + L +S K
Sbjct: 1266 GKQNEENPGDEEAK--NQVNSESD--SDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTK 1321
Query: 774 PVSKSPERLRKDIEVLSEDTD--------------YEEDEVTKKRKDVKKDTTDKSSKPQ 819
P + R +V SED++ EDE + + KK +++ +
Sbjct: 1322 PKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSY 1381
Query: 820 IKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKY 879
++ KRR +E + + EE+ + KE E +E+E+E +P K
Sbjct: 1382 KQKKKRRRIKVQEDSSSENKSNSEEEEEEKEE--EEEEEEEEEEEEEDENDDSKSPGK-- 1437
Query: 880 NGLEEKRKSLR----TTGFYSGFSEVAEKRIKLLNNSDER 915
G ++ RK L+ T + E E+R ++ ER
Sbjct: 1438 -GRKKIRKILKDDKLRTETQNALKEEEERRKRIAERERER 1476
Score = 56.6 bits (135), Expect = 2e-07
Identities = 86/429 (20%), Positives = 167/429 (38%), Gaps = 67/429 (15%)
Query: 415 KQCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIER--------KENIK 466
K+ + K + VKE+ ++ ++ +I IED+ + ++ IK
Sbjct: 1130 KKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIK 1189
Query: 467 PSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAK 526
P +NL+ S T Q +DD DDD + + K+ EE KA
Sbjct: 1190 PVT---ENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDP-ENRIAKKMLLEEIKAN 1245
Query: 527 SGDETNKEEDEDDEEAEEEEEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQK 586
+ + D++ EE ++ ++ EE D++ N+ + RY +
Sbjct: 1246 LSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRY----RHR 1301
Query: 587 MYEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLD 646
+ + SD E GE +K +P + K ++R+K+ ++
Sbjct: 1302 LLRHKLTVSDGESGE--------------------EKKTKPKEHKEVKGRNRRKVSSEDS 1341
Query: 647 KEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNS-----DTAHIKSIEIT 701
++ D E + +S+ + P K +L + + S IK E +
Sbjct: 1342 EDSDFQESGVSE-----EVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDS 1396
Query: 702 SI---LNGLQASESSAEDSEQEDERGAQDMDNN------GKEESKIDHLTNNRNDLISKE 752
S N + E E+ E+E+E ++ D N GK KI + ++D + E
Sbjct: 1397 SSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKIL--KDDKLRTE 1454
Query: 753 EQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTT 812
QN+ L+E + + + + E+LR+ IE+ ED + +T K + D
Sbjct: 1455 TQNA---LKEEEERRKRIAER--EREREKLREVIEI--EDASPTKCPITTK---LVLDED 1504
Query: 813 DKSSKPQIK 821
+++ +P ++
Sbjct: 1505 EETKEPLVQ 1513
Score = 53.1 bits (126), Expect = 2e-06
Identities = 109/527 (20%), Positives = 201/527 (38%), Gaps = 61/527 (11%)
Query: 803 KRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSS 862
++KD+ K S K + TEE S G + +K+ KE E ++ S
Sbjct: 415 EKKDISKSEAKLSRKQVDSEHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPANTSED 474
Query: 863 DEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAK 922
+ + + P + LE + + S E+ ++ +S +L N +K
Sbjct: 475 LDMDIVSVPSSVPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVE---SSSVKL-NISSK 530
Query: 923 DRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSV 982
D + I+ + K KEL+ + ++ P + +E Q +SC +
Sbjct: 531 DNR---GGIKSKTTAKVTKELYVKLTPVSLSNSPIKGAD---CQEVPQDKDGYKSCGLNP 584
Query: 983 ELEK--PPPVNVDSKPIEEKTV----EVND--RKAEFPSSGSNSVLNTPPTTPESPSSVT 1034
+LEK N D++ + E V E +D R ++ T P T S
Sbjct: 585 KLEKCGLGQENSDNEHLVENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEECN 644
Query: 1035 VTEGSRQQSSVTV--------SEPLAPNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGN 1086
T +Q+ SV V S+ N + + KS+ T++ +S + E+ + E +
Sbjct: 645 ETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVS 704
Query: 1087 --SSPAGFDASVSSSSSNQPE----PEHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATV 1140
S + D ++ +N K G+++ K + G K+ +S K+++
Sbjct: 705 RMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSI 764
Query: 1141 VNNKKKGKGTNSS--DSEELSAGESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCGKNG 1198
++ KK+ + SS DSE +S++K ++ + + + + K G +
Sbjct: 765 ISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDN 824
Query: 1199 DKDPDLKEPSNRLPKVYKWSFQMSDLENMTSAERITILQEKLQEIRKHYLSLKSEV---A 1255
+LK TS E + E+ QE R+ + S + V
Sbjct: 825 QGHKNLK----------------------TSQEGSSDDAERKQE-RETFSSAEGTVDKDT 861
Query: 1256 SIDRRRKRLKKKERESAATSS-SSSSPSSSSITAAVMLTLAEPSMSS 1301
+I R RL KK++ SA+T S S T+ + +AE S
Sbjct: 862 TIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKS 908
Score = 43.5 bits (101), Expect = 0.001
Identities = 45/179 (25%), Positives = 74/179 (41%), Gaps = 17/179 (9%)
Query: 134 PVIGKKTNRGRRSNHIPEEES-------SSSSSDEDEDDRKQIDELLGKVVCVDYISLDK 186
P GKK + + +EE+ S S S+E + R + L K+ D S ++
Sbjct: 1258 PEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEE 1317
Query: 187 KKALWFPALVVCPDCSDEIAVK-KDNILVRSFKDGKFT-SVPRKDVHEITSDTAPKPDAV 244
KK P E+ + + + +D F S ++V E + P+ +
Sbjct: 1318 KKTK--------PKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSA 1369
Query: 245 LKQAFEQALEFHKSRTIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIE 303
K E+ +K + K + S + EEEEEE +E+E+E+ EEEEE E
Sbjct: 1370 KKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDE 1428
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 75.1 bits (183), Expect = 4e-13
Identities = 218/1134 (19%), Positives = 413/1134 (36%), Gaps = 172/1134 (15%)
Query: 208 KKDNILVRSFKDGKFTSVPRKDVHEITSDTAPKPDAVLKQAFEQALEFHKSRTIPANWKT 267
K+ N D KF + RK + + K + +Q H + +P +
Sbjct: 425 KEKNTKEHKVIDAKFETKARKGEKPCALEKKDISKSEAKLSRKQVDSEHMHQNVPTEEQR 484
Query: 268 ELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEE-RENFLQQLYKFME----- 321
K S+ E ++ + +E+ + E + S + + +I P E+ + L ME
Sbjct: 485 TNK--STGGEHKKSDRKEEPQYEPANTSEDLDMDIVSVPSSVPEDIFENLETAMEVQSSV 542
Query: 322 ----DRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSA 377
D + + LN+ GG + + V K++Y L L+++
Sbjct: 543 DHQGDGSSGTEQEVESSSVKLNISSK----DNRGGIKSKTTAKVTKELYVKLTPVSLSNS 598
Query: 378 AGYNVKCAYKKYLYGFEEYCRSANIEFQMALPEKVVNKQCKECENVKEIKVKEENETEIK 437
C Q +K K C +++ + +EN
Sbjct: 599 PIKGADC--------------------QEVPQDKDGYKSCGLNPKLEKCGLGQENSDN-- 636
Query: 438 EIKMEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDN 497
E +E E +++ E ++ R +K + + + ++SD+E +K+ +
Sbjct: 637 EHLVENEVSLLLEES-----DLRRSPRVKTTPLRRPTETNPVTSNSDEECNETVKEKQKL 691
Query: 498 ENLDDKDDDTTRVDESLNIKVEAEEEKAKSGDETNKEEDEDDEEAEEEEEEEEEEEDEDD 557
K D D +++ + K+K + ++ D D+ A +E D
Sbjct: 692 SVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSD 751
Query: 558 DDNNEEEEFECYPPGMKVQV-RYGRGKNQKMYEASIKDSDVEGGEVLYLV-------HYC 609
D NE +K Q + +GK ++ S D D + G+
Sbjct: 752 TDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQ 811
Query: 610 GWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPP 669
+ YD + +K ++ K +K+I N D + +DEK+S K
Sbjct: 812 SESSNYDS--ELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKG---------- 859
Query: 670 FQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMD 729
+D KN T + E S++D+E++ ER +
Sbjct: 860 ------------MDNQGHKNLKT----------------SQEGSSDDAERKQER-----E 886
Query: 730 NNGKEESKIDHLTN--NRNDLISKEEQNSSSLLEENKVHA--DLVISKPVSKSPERLRKD 785
E +D T D + K++Q S+S +K+ S V K E K
Sbjct: 887 TFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKS 946
Query: 786 IEVLSEDTDYEEDEVTK-KRKDVKKDTTDKSS---KPQIKRG----------KRRYCNTE 831
+ ++ +D ++ K +KKD +D++S K Q K+G K++ E
Sbjct: 947 KHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKME 1006
Query: 832 ECLKTGSPGKKEEKAKNKESLC-----MENSSNSSSDEDEEETKAKMTPTKKYNGLEEKR 886
+ ++ S G EK +E +C ++ N ++D +++ K + +KK + L
Sbjct: 1007 QQYESSSDG--TEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDEL---- 1060
Query: 887 KSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSD 946
S ++E + + ++S+++ + A R+ + G+ +K ++ S
Sbjct: 1061 ---------SDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRK--RQDCSS 1109
Query: 947 SDTEAAASPPHPAPEEGV--AEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKTVEV 1004
SDTE + E+G +++ L+ + E + S + + S E++ E
Sbjct: 1110 SDTE-----KYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSED 1164
Query: 1005 NDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSE 1064
N +K + SS +V+ E + T R+Q+ +T S ++ SI
Sbjct: 1165 NKKKKQRTSSKKKAVI-----VKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEG 1219
Query: 1065 TDSTIEVDSVAGELQDLQSEGNSSPAGFDA---SVSSSSSNQPEPEHPEKACTGQKRVKD 1121
+ ++ V L G +G +A SV + + + PE + +++
Sbjct: 1220 SSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEE 1279
Query: 1122 AQGGGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESITKSQPVKSVSTGMKSHS 1181
+ SS + + ++GK +EE + G+ K+Q V S S S
Sbjct: 1280 IKANLSSDEDGSSD------DEPEEGKKRTGKQNEE-NPGDEEAKNQ-VNSESDSDSEES 1331
Query: 1182 TKSPAR--------TQSPGKCGKNGDKDP-DLKEPSNR-LPKVYKWSFQMSDLENMTSAE 1231
K R T S G+ G+ P + KE R KV + SD + +E
Sbjct: 1332 KKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSE 1391
Query: 1232 RITILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSSSSSPSSSS 1285
++ E E R S K ++R + KKK R SSS S+S
Sbjct: 1392 EVS---ESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNS 1442
Score = 60.5 bits (145), Expect = 1e-08
Identities = 41/125 (32%), Positives = 69/125 (55%), Gaps = 12/125 (9%)
Query: 443 EERNIIPREEKPIEDEIERKENIKPSLGS---KKNLLESIPTHSDQEKEV--NIKKPEDN 497
EE+ P+E K ++ RK + + S S + + E + D+++ + KK E
Sbjct: 1354 EEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELE 1413
Query: 498 ENLDDKDDDTTRVDESLNIKVEAEEEKAKSGDETNKEEDEDDEEAEEEEEEEEEEEDEDD 557
EN R IKV+ E + S +++N EE+E+++E EEEEEEEEEEE+ED+
Sbjct: 1414 ENQRSYKQKKKR----RRIKVQ---EDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDE 1466
Query: 558 DDNNE 562
+D+++
Sbjct: 1467 NDDSK 1471
Score = 58.9 bits (141), Expect = 3e-08
Identities = 113/580 (19%), Positives = 211/580 (36%), Gaps = 113/580 (19%)
Query: 386 YKKYLYGFEEYCRSANIEFQMALPEKVVNKQCKECENVKEIKVKEENETEIKEIKMEEER 445
+KK + E+ S++ + LPE+ + C + +K+IK N T E K ++ R
Sbjct: 998 FKKKVIKMEQQYESSS-DGTEKLPER--EEICHFPKGIKQIK----NGTTDGEKKSKKIR 1050
Query: 446 NIIPREEKPIEDEIERKENIKPSLGSKKNLLESIPTHSDQEKEVNIK----------KPE 495
+ +++ + D E+ S S ++ + ++K +
Sbjct: 1051 DKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSS 1110
Query: 496 DNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGDETNKEEDEDDEEAEEEEEEEEEEEDE 555
D E K+D D+ L ++E E + S KE ++ EE E+ ++ +
Sbjct: 1111 DTEKYSMKEDGCNSSDKRLK-RIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKK 1169
Query: 556 DDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEASI---KDSDVEGGEVLYLVHYCGWN 612
+ ++ +K + R + K +A I SD+E +
Sbjct: 1170 QRTSSKKKAVI------VKEKKRNSLRTSTKRKQADITSSSSSDIEDDD----------- 1212
Query: 613 VRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQT 672
+N + + ++K P L S F
Sbjct: 1213 -----------------------------QNSIGEGSSDEQKIKPVTENLVLSSHTGFCQ 1243
Query: 673 NPSPEMVSK-LDLT-DAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDE-------R 723
+ E +SK + +T D + D I +L ++A+ SS ED +DE
Sbjct: 1244 SSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRT 1303
Query: 724 GAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVIS----------K 773
G Q+ +N G EE+K + N+ +D S E++ + L +S K
Sbjct: 1304 GKQNEENPGDEEAK--NQVNSESD--SDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTK 1359
Query: 774 PVSKSPERLRKDIEVLSEDTD--------------YEEDEVTKKRKDVKKDTTDKSSKPQ 819
P + R +V SED++ EDE + + KK +++ +
Sbjct: 1360 PKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSY 1419
Query: 820 IKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKY 879
++ KRR +E + + EE+ + KE E +E+E+E +P K
Sbjct: 1420 KQKKKRRRIKVQEDSSSENKSNSEEEEEEKEE--EEEEEEEEEEEEEDENDDSKSPGK-- 1475
Query: 880 NGLEEKRKSLR----TTGFYSGFSEVAEKRIKLLNNSDER 915
G ++ RK L+ T + E E+R ++ ER
Sbjct: 1476 -GRKKIRKILKDDKLRTETQNALKEEEERRKRIAERERER 1514
Score = 56.6 bits (135), Expect = 2e-07
Identities = 86/429 (20%), Positives = 167/429 (38%), Gaps = 67/429 (15%)
Query: 415 KQCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIER--------KENIK 466
K+ + K + VKE+ ++ ++ +I IED+ + ++ IK
Sbjct: 1168 KKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIK 1227
Query: 467 PSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAK 526
P +NL+ S T Q +DD DDD + + K+ EE KA
Sbjct: 1228 PVT---ENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDP-ENRIAKKMLLEEIKAN 1283
Query: 527 SGDETNKEEDEDDEEAEEEEEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQK 586
+ + D++ EE ++ ++ EE D++ N+ + RY +
Sbjct: 1284 LSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRY----RHR 1339
Query: 587 MYEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLD 646
+ + SD E GE +K +P + K ++R+K+ ++
Sbjct: 1340 LLRHKLTVSDGESGE--------------------EKKTKPKEHKEVKGRNRRKVSSEDS 1379
Query: 647 KEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNS-----DTAHIKSIEIT 701
++ D E + +S+ + P K +L + + S IK E +
Sbjct: 1380 EDSDFQESGVSE-----EVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDS 1434
Query: 702 SI---LNGLQASESSAEDSEQEDERGAQDMDNN------GKEESKIDHLTNNRNDLISKE 752
S N + E E+ E+E+E ++ D N GK KI + ++D + E
Sbjct: 1435 SSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKIL--KDDKLRTE 1492
Query: 753 EQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTT 812
QN+ L+E + + + + E+LR+ IE+ ED + +T K + D
Sbjct: 1493 TQNA---LKEEEERRKRIAER--EREREKLREVIEI--EDASPTKCPITTK---LVLDED 1542
Query: 813 DKSSKPQIK 821
+++ +P ++
Sbjct: 1543 EETKEPLVQ 1551
Score = 53.1 bits (126), Expect = 2e-06
Identities = 109/527 (20%), Positives = 201/527 (38%), Gaps = 61/527 (11%)
Query: 803 KRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSS 862
++KD+ K S K + TEE S G + +K+ KE E ++ S
Sbjct: 453 EKKDISKSEAKLSRKQVDSEHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPANTSED 512
Query: 863 DEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAK 922
+ + + P + LE + + S E+ ++ +S +L N +K
Sbjct: 513 LDMDIVSVPSSVPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVE---SSSVKL-NISSK 568
Query: 923 DRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSV 982
D + I+ + K KEL+ + ++ P + +E Q +SC +
Sbjct: 569 DNR---GGIKSKTTAKVTKELYVKLTPVSLSNSPIKGAD---CQEVPQDKDGYKSCGLNP 622
Query: 983 ELEK--PPPVNVDSKPIEEKTV----EVND--RKAEFPSSGSNSVLNTPPTTPESPSSVT 1034
+LEK N D++ + E V E +D R ++ T P T S
Sbjct: 623 KLEKCGLGQENSDNEHLVENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEECN 682
Query: 1035 VTEGSRQQSSVTV--------SEPLAPNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGN 1086
T +Q+ SV V S+ N + + KS+ T++ +S + E+ + E +
Sbjct: 683 ETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVS 742
Query: 1087 --SSPAGFDASVSSSSSNQPE----PEHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATV 1140
S + D ++ +N K G+++ K + G K+ +S K+++
Sbjct: 743 RMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSI 802
Query: 1141 VNNKKKGKGTNSS--DSEELSAGESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCGKNG 1198
++ KK+ + SS DSE +S++K ++ + + + + K G +
Sbjct: 803 ISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDN 862
Query: 1199 DKDPDLKEPSNRLPKVYKWSFQMSDLENMTSAERITILQEKLQEIRKHYLSLKSEV---A 1255
+LK TS E + E+ QE R+ + S + V
Sbjct: 863 QGHKNLK----------------------TSQEGSSDDAERKQE-RETFSSAEGTVDKDT 899
Query: 1256 SIDRRRKRLKKKERESAATSS-SSSSPSSSSITAAVMLTLAEPSMSS 1301
+I R RL KK++ SA+T S S T+ + +AE S
Sbjct: 900 TIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKS 946
Score = 43.5 bits (101), Expect = 0.001
Identities = 45/179 (25%), Positives = 74/179 (41%), Gaps = 17/179 (9%)
Query: 134 PVIGKKTNRGRRSNHIPEEES-------SSSSSDEDEDDRKQIDELLGKVVCVDYISLDK 186
P GKK + + +EE+ S S S+E + R + L K+ D S ++
Sbjct: 1296 PEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEE 1355
Query: 187 KKALWFPALVVCPDCSDEIAVK-KDNILVRSFKDGKFT-SVPRKDVHEITSDTAPKPDAV 244
KK P E+ + + + +D F S ++V E + P+ +
Sbjct: 1356 KKTK--------PKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSA 1407
Query: 245 LKQAFEQALEFHKSRTIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIE 303
K E+ +K + K + S + EEEEEE +E+E+E+ EEEEE E
Sbjct: 1408 KKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDE 1466
>gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1
[Homo sapiens]
Length = 651
Score = 75.1 bits (183), Expect = 4e-13
Identities = 106/517 (20%), Positives = 206/517 (39%), Gaps = 104/517 (20%)
Query: 410 EKVVNKQCKECENVKEIKVKEENETE-IKEIKMEEERNIIPREEKPIEDEIERKENIKPS 468
+++V ++ K + +K +E E K+ K E N + K + +K+ K S
Sbjct: 145 KQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDK-KDS 203
Query: 469 LGSKKNLLESIPTHSDQEKEVNIKKP----------EDNENLD------DKDDDT----- 507
SKK E + T ++ +K++ K E++ N+D DD++
Sbjct: 204 KNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDA 263
Query: 508 --------------------TRVDESLNIKV--EAEEEKAKSGDETNKEEDEDDEEAEEE 545
T+ D N K +AE E +K + +K+ ++ ++ +++
Sbjct: 264 WLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKK 323
Query: 546 EEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGGEVLYL 605
++ +++ E D + + ++E + K + + K+ K Y S +D E G+
Sbjct: 324 KDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPES---TDTESGDAK-- 378
Query: 606 VHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRL 665
+ R D + ++ A KN K K KKI D E + + K S K+
Sbjct: 379 ------DARNDS-----RNLKKASKNDDKKKDAKKITFSTDSESELESKESQKD------ 421
Query: 666 SKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQE-DERG 724
K D D+K + +K+ E ES+ DSE + D +
Sbjct: 422 --------------EKKDKKDSKTDNKKSVKNDE-----------ESTDADSEPKGDSKK 456
Query: 725 AQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRK 784
+ + GK++SK D + E S L+++K H SK S + ++K
Sbjct: 457 GKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKH-----SKEKKGSKKDIKK 511
Query: 785 DIEVLSEDTDYEEDEVTK---KRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGK 841
D +E TD E DE +K K K + +S + K G ++ + + S
Sbjct: 512 DARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDESDGTSANS--- 568
Query: 842 KEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKK 878
K E ++K M + + +++ E+ + ++ P+++
Sbjct: 569 KMEGLESKRGFRMSSKKTTFNEKGEKASTGRVPPSRE 605
Score = 53.1 bits (126), Expect = 2e-06
Identities = 88/448 (19%), Positives = 186/448 (41%), Gaps = 77/448 (17%)
Query: 218 KDGKFTSVPRKDVHEITSDTAPKPDA--VLKQAFEQALEFHKSRTIPANWKTELKEDSSS 275
KD K + +KD + A P++ ++++ ++ E K+ ++ + K+ SS
Sbjct: 119 KDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSS 178
Query: 276 SEAEEEEEEED------DEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGTPINK 329
SE E + +K+K+D+ + ++ E F + N + L K + PI++
Sbjct: 179 SETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTE-FLHTKNNPKKDL-KRSKTSNDPISE 236
Query: 330 RPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKY 389
+ +LN+ L + N ++ W + Y N++ Y++K Y KY
Sbjct: 237 --ICSENSLNVDFLMLVGQSDDESINFDA---WLRNYSQ------NNSKNYSLK--YTKY 283
Query: 390 LYGF--EEYCRSANIEFQMALP----EKVVNKQCKECENVKEIKVKEENETEIKEIKMEE 443
+ +S++ E + + K V K K+ + K++K K+ T+ + ++
Sbjct: 284 TKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVK-KDTESTDAESGDSKD 342
Query: 444 ERNIIPREEKPIEDEIERKE-----------------------NIKPSLGS--KKNLLES 478
ER +++K ++ + ++K+ N+K + + KK +
Sbjct: 343 ERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKK 402
Query: 479 IPTHSDQEKEVNIKKPEDNENLDDKDDDTTRV------DESLNIKVE--AEEEKAKSGDE 530
I +D E E+ K+ + +E D KD T +ES + E + +K K ++
Sbjct: 403 ITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEK 462
Query: 531 TNKEEDEDDEEAEEEEEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEA 590
K++ + D++ ++ ++ E E E D + ++++ G K ++ K+ + +A
Sbjct: 463 KGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDA 522
Query: 591 --------------SIKDSDVEGGEVLY 604
IK SD E E LY
Sbjct: 523 EFDESSKTGFKTSTKIKGSDTESEESLY 550
Score = 52.8 bits (125), Expect = 2e-06
Identities = 97/506 (19%), Positives = 187/506 (36%), Gaps = 74/506 (14%)
Query: 714 AEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISK 773
AE + +DE+G + + K++ + TN S ++EE +
Sbjct: 113 AEYKKSKDEKGGTPLKKDSKKKGG-SYATN----------PESKQIVEEKTKRQNEADKT 161
Query: 774 PVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEEC 833
P+ S E + S +T+ E ++ K V K+ + K K K K+ NTE
Sbjct: 162 PLKSSHENEQSKKSKSSSETNPE----SQNSKTVSKNCSQKDKKDS-KNSKKT--NTEFL 214
Query: 834 LKTGSPGKKEEKAKNKES----LCMENSSN-------SSSDEDEEETKAKMTPTKKYNGL 882
+P K +++K +C ENS N SD++ A + + Y+
Sbjct: 215 HTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWL---RNYSQN 271
Query: 883 EEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKE 942
K SL+ T + + +K K ++++ KD K V +++ KK +K+
Sbjct: 272 NSKNYSLKYTKYTK---KDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKK 328
Query: 943 LFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKTV 1002
+D E+ S +E T +++ K D+K E T
Sbjct: 329 DTESTDAESGDSK----------DERKDTKKDKKKL-------KKDDKKKDTKKYPEST- 370
Query: 1003 EVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIK 1062
+ A+ + S ++ + + +T + +S + E +++ + K
Sbjct: 371 DTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSK 430
Query: 1063 SETDSTIEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQKRVKDA 1122
++ +++ D + ++ +S P G S + + + +K + KDA
Sbjct: 431 TDNKKSVKNDEES-------TDADSEPKG------DSKKGKKDEKKGKKDSKKDDKKKDA 477
Query: 1123 QGGGSSSK-------KQKRSHKATVVNNKKKGKGTNSSDSEELSAGESITKSQPVKSVST 1175
+ S++ K+ + H +KK K D+E A E S+ ST
Sbjct: 478 KKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDA-EFDESSKTGFKTST 536
Query: 1176 GMKSHSTKSPARTQSPGKCGKNGDKD 1201
+K T+S PG K + D
Sbjct: 537 KIKGSDTESEESLYKPGAKKKIDESD 562
Score = 50.1 bits (118), Expect = 1e-05
Identities = 110/560 (19%), Positives = 207/560 (36%), Gaps = 79/560 (14%)
Query: 487 KEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAE---EEKAKSGDETNKEEDEDDEEAE 543
K+ KK +D + D+ + S E++ EEK K +E +K + E E
Sbjct: 111 KKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENE 170
Query: 544 EEEEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGGEVL 603
+ ++ + E + N++ C +QK + S K+S E L
Sbjct: 171 QSKKSKSSSETNPESQNSKTVSKNC---------------SQKDKKDS-KNSKKTNTEFL 214
Query: 604 YLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLR 663
+ KN PK K K+ K D + + S L
Sbjct: 215 HT------------------------KNNPK-KDLKRSKTSNDPISEICSENSLNVDFLM 249
Query: 664 RLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDER 723
+ + ++ + ++KN + K + + N ++S++ +EDS+ +
Sbjct: 250 LVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKD 309
Query: 724 GAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLR 783
+ N K++ K D + D S + ++ S E D K + K ++
Sbjct: 310 SKKVKKNVKKDDKKKDV----KKDTESTDAESGDSKDERKDTKKD---KKKLKKDDKK-- 360
Query: 784 KDIEVLSEDTDYEEDEVTKKRKD---VKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPG 840
KD + E TD E + R D +KK + + K K K + E
Sbjct: 361 KDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAK--KITFSTDSESELESKES 418
Query: 841 KKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPT-KKYNGLEEKRKSLRTTGFYSGFS 899
+K+EK K+S + + S DEE T A P G ++++K + S
Sbjct: 419 QKDEKKDKKDS---KTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKD-------S 468
Query: 900 EVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPA 959
+ +K+ N++ S + +KD S + + KK +K+ + DTE+ + +
Sbjct: 469 KKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKK-DARKDTESTDAEFDES 527
Query: 960 PEEGVAE----ESLQTVAEEESCSPSV--ELEKPPPVNVDSK--PIEEKT-VEVNDRKAE 1010
+ G + T +EE P ++++ + +SK +E K ++ +K
Sbjct: 528 SKTGFKTSTKIKGSDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTT 587
Query: 1011 FPSSGSNSVLNTPPTTPESP 1030
F G + P + E P
Sbjct: 588 FNEKGEKASTGRVPPSREKP 607
Score = 45.1 bits (105), Expect = 5e-04
Identities = 96/487 (19%), Positives = 184/487 (37%), Gaps = 77/487 (15%)
Query: 815 SSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMT 874
+SK +K+ + + E K G+P KK+ K K S ++ + + +A T
Sbjct: 105 TSKTHLKKAEYKKSKDE---KGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKT 161
Query: 875 PTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQ 934
P K + E+ +KS SE + NS +N KD+KD +S
Sbjct: 162 PLKSSHENEQSKKS-------KSSSETNPES----QNSKTVSKNCSQKDKKDSKNS---- 206
Query: 935 WPKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPS----VELEKPPPV 990
KKT E + +P + + + + E S + V +
Sbjct: 207 --KKTNTEFLHTKN-----NPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESI 259
Query: 991 NVDSKPIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEP 1050
N D+ + N+ K + +T +S + + ++ S V +
Sbjct: 260 NFDA---WLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKN 316
Query: 1051 LAPNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSNQPEPEHPE 1110
+ + ++ + +K +T+ST D+ +G+ +D + + + + ++PE
Sbjct: 317 VKKDDKK-KDVKKDTEST---DAESGDSKDERKDTKKD----KKKLKKDDKKKDTKKYPE 368
Query: 1111 KACTGQKRVKDAQGGGSSSKKQKRSHKATVVNNKKKG--KGTNSSDSE-ELSAGES---- 1163
T KDA+ + KK ++ ++KKK K T S+DSE EL + ES
Sbjct: 369 STDTESGDAKDARNDSRNLKKASKN------DDKKKDAKKITFSTDSESELESKESQKDE 422
Query: 1164 -----ITKSQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDKDPDLKEPSNRLPKVYKWS 1218
+K+ KSV ST + + + K GK +K + K K +
Sbjct: 423 KKDKKDSKTDNKKSVKN--DEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKN 480
Query: 1219 FQMSDLENMTSAERITILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSSS 1278
+ +++E+ +L++ +KH K +K +KK R+ ++ +
Sbjct: 481 AESTEMES----------DLELKKDKKHSKEKKGS-------KKDIKKDARKDTESTDAE 523
Query: 1279 SSPSSSS 1285
SS +
Sbjct: 524 FDESSKT 530
>gi|46852388 cell-cycle and apoptosis regulatory protein 1 [Homo
sapiens]
Length = 1150
Score = 74.7 bits (182), Expect = 5e-13
Identities = 121/565 (21%), Positives = 234/565 (41%), Gaps = 109/565 (19%)
Query: 268 ELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEE----EEIEPFPEERENFLQQLYKFMEDR 323
E KE+ E E+EE+EDD+++ ED+ EEE EEIE ER L
Sbjct: 674 EQKEEQKELEKSEKEEDEDDDRKSEDDKEEEERKRQEEIERQRRERRYILP--------- 724
Query: 324 GTPINKRPVLGYRNLNLFKLFRLVHKLGGFD-NIESGAVWKQVYQDLGIPVLNSAAGYNV 382
++ ++ + N K G FD +I S +V +L+ N
Sbjct: 725 ----DEPAIIVHPN--------WAAKSGKFDCSIMSLSV-----------LLDYRLEDNK 761
Query: 383 KCAYKKYLYGFEEYCRSANIEFQMALPEKVVNKQCKECENVKEIKVKEENETEIKEIKME 442
+ +++ L+ E + +F + + + +++ KE + K+ K K++ + KE + +
Sbjct: 762 EHSFEVSLFA-ELFNEMLQRDFGVRIYKSLLSLPEKEDKKEKDKKSKKDERKDKKEERDD 820
Query: 443 EERNIIPREEKPIEDEIERKENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDD 502
E P+ K +D+ D++++ + +K ED D
Sbjct: 821 ETDEPKPKRRKSGDDK-------------------------DKKEDRDERKKEDKRKDDS 855
Query: 503 KDDDTTRVDESLNIKVEAEEEKAKSGDETNKEEDEDDEEAEEEEEEEEEEEDEDDDDNNE 562
KDDD T +E N +++ D EAEE E+EE++ ++E+ ++
Sbjct: 856 KDDDET--------------------EEDNNQDEYDPMEAEEAEDEEDDRDEEEMTKRDD 895
Query: 563 EEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGGEVLYLVHYCGWNVRYD-EWIKA 621
+ + Y + R + K ++ + + D+ V + +CG+ + D E I
Sbjct: 896 KRDINRY-----CKERPSKDKEKEKTQMITINRDLLMAFVYFDQSHCGYLLEKDLEEILY 950
Query: 622 DKIVRPADKNVPKIKHRKKIKNK------LDKEKDKDEKYSPKNCKLRRLSKPPFQTNPS 675
+ + V K+ ++ ++ D KD++ ++ + L P+
Sbjct: 951 TLGLHLSRAQVKKLLNKVVLRESCFYRKLTDTSKDEENHEESESLQEDMLGNRLLLPTPT 1010
Query: 676 PEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEE 735
+ SK D+ + + +++ S+L L+ SE + EQ+ + + D ++E
Sbjct: 1011 VKQESK-DVEENVGLIVYNGAMVDVGSLLQKLEKSEKVRAEVEQKLQLLEEKTD---EDE 1066
Query: 736 SKIDHLTNNRNDLIS--KEEQNSSSLLEENKVHADLVISKPVSKSPE-RLRKDIEVLSED 792
I +L N+ L +E + S L+EN L IS+ ++ E ++ K I LS
Sbjct: 1067 KTILNLENSNKSLSGELREVKKDLSQLQEN-----LKISENMNLQFENQMNKTIRNLS-- 1119
Query: 793 TDYEEDEVTKKRKDVKKDTTDKSSK 817
T +E K+ +VK + D+ SK
Sbjct: 1120 TVMDEIHTVLKKDNVKNEDKDQKSK 1144
Score = 63.5 bits (153), Expect = 1e-09
Identities = 105/518 (20%), Positives = 199/518 (38%), Gaps = 72/518 (13%)
Query: 450 REEKPIEDEIERKENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTR 509
R+E E + E K++ G K + S PTH + +K + + L+ + +
Sbjct: 605 RKEADGEQDEEEKDD-----GEAKEI--STPTHWSKLDPKTMKVNDLRKELESRALSSKG 657
Query: 510 VDESL------NIKVEAEEEKAKSGDETNKEEDEDDEEAEEEEEEEEEEEDEDDDDNNEE 563
+ L +KVE ++E+ K +++ KEEDEDD+ E+++EEEE + +++ +
Sbjct: 658 LKSQLIARLTKQLKVEEQKEEQKELEKSEKEEDEDDDRKSEDDKEEEERKRQEEIERQRR 717
Query: 564 EEFECYPPGMKVQVRYGRGKNQKMYEASI-----------KDSDVEGGEVLYLVHYCGWN 612
E P + V ++ SI +D+ EV
Sbjct: 718 ERRYILPDEPAIIVHPNWAAKSGKFDCSIMSLSVLLDYRLEDNKEHSFEVSLFAELFNEM 777
Query: 613 VRYDEWIKADK----IVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKP 668
++ D ++ K + DK K K KK + K KE+ DE PK RR S
Sbjct: 778 LQRDFGVRIYKSLLSLPEKEDKK-EKDKKSKKDERKDKKEERDDETDEPK--PKRRKSGD 834
Query: 669 PFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDE------ 722
+ K D + D + + ++A E+ E+ ++++E
Sbjct: 835 DKDKKEDRDERKKEDKRKDDSKDDDETEEDNNQDEYDPMEAEEAEDEEDDRDEEEMTKRD 894
Query: 723 ------RGAQDMDNNGKEESKIDHLTNNRNDLIS---KEEQNSSSLLEENKVHADLVISK 773
R ++ + KE+ K +T NR+ L++ ++ + LLE++ +
Sbjct: 895 DKRDINRYCKERPSKDKEKEKTQMITINRDLLMAFVYFDQSHCGYLLEKDLEEILYTLGL 954
Query: 774 PVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEEC 833
+S++ + + VL E Y +K D KD + ++
Sbjct: 955 HLSRAQVKKLLNKVVLRESCFY------RKLTDTSKDEENHEESESLQED---MLGNRLL 1005
Query: 834 LKTGSPGKKEEKAKNKESLCMENSS----NSSSDEDEEETKAKMTPTKKYNGLEEKRKSL 889
L T + ++ + + L + N + S + E+ K + +K LEEK
Sbjct: 1006 LPTPTVKQESKDVEENVGLIVYNGAMVDVGSLLQKLEKSEKVRAEVEQKLQLLEEK---- 1061
Query: 890 RTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKDV 927
++ EK I L NS++ L + +KD+
Sbjct: 1062 ---------TDEDEKTILNLENSNKSLSGELREVKKDL 1090
Score = 40.0 bits (92), Expect = 0.015
Identities = 78/386 (20%), Positives = 147/386 (38%), Gaps = 94/386 (24%)
Query: 218 KDGKFTSVPRKDVHEITSDTA--PKPDAVLKQAFEQALEFHKSRTIPANWKTELKEDSSS 275
KD K RKD E D PKP + E R K + K+D +
Sbjct: 802 KDKKSKKDERKDKKEERDDETDEPKPKRRKSGDDKDKKEDRDERKKEDKRKDDSKDDDET 861
Query: 276 SE-----------AEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRG 324
E AEE E+EEDD E+E +++ +I + +ER + ++ K +
Sbjct: 862 EEDNNQDEYDPMEAEEAEDEEDDRDEEEMTKRDDKRDINRYCKERPSKDKEKEK---TQM 918
Query: 325 TPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKC 384
IN+ ++ + VY D S GY ++
Sbjct: 919 ITINRDLLMAF-----------------------------VYFD------QSHCGYLLEK 943
Query: 385 AYKKYLYGFEEYCRSANIEFQMALPEKVVNKQCKECENVKEIKVKEENETEIKEIK--ME 442
++ LY + A ++ L KVV ++ + + EEN E + ++ M
Sbjct: 944 DLEEILYTLGLHLSRAQVK---KLLNKVVLRESCFYRKLTDTSKDEENHEESESLQEDML 1000
Query: 443 EERNIIP-----REEKPIED-------------------EIERKENIKPSLGSKKNLLES 478
R ++P +E K +E+ ++E+ E ++ + K LLE
Sbjct: 1001 GNRLLLPTPTVKQESKDVEENVGLIVYNGAMVDVGSLLQKLEKSEKVRAEVEQKLQLLEE 1060
Query: 479 IPTHSDQEKEVNIK---KPEDNENLDDKDD-----DTTRVDESLNIKVEAEEEKAKSG-- 528
T D++ +N++ K E + K D + ++ E++N++ E + K
Sbjct: 1061 -KTDEDEKTILNLENSNKSLSGELREVKKDLSQLQENLKISENMNLQFENQMNKTIRNLS 1119
Query: 529 ---DETNKEEDEDDEEAEEEEEEEEE 551
DE + +D+ + E+++++ +E
Sbjct: 1120 TVMDEIHTVLKKDNVKNEDKDQKSKE 1145
Score = 32.7 bits (73), Expect = 2.3
Identities = 62/345 (17%), Positives = 132/345 (38%), Gaps = 49/345 (14%)
Query: 533 KEEDEDDEEAEEEEEEEEEEEDEDDDDNNEEEEFECY-----PPGMKVQVRYGRGKNQKM 587
K++ + + E +E + E++E+E DD +E + P MKV +++ +
Sbjct: 594 KQQLVEKLQGERKEADGEQDEEEKDDGEAKEISTPTHWSKLDPKTMKVNDLRKELESRAL 653
Query: 588 YEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDK 647
+K L+ ++ +E + K + ++K + RK +K ++
Sbjct: 654 SSKGLKSQ---------LIARLTKQLKVEEQKEEQKELEKSEKEEDEDDDRKSEDDKEEE 704
Query: 648 EKDKDEKYSPKNCKLRRL--SKPPFQTNPS---------PEMVSKLDLTDAKNSDTAHIK 696
E+ + E+ + + R + +P +P+ ++S L D + D
Sbjct: 705 ERKRQEEIERQRRERRYILPDEPAIIVHPNWAAKSGKFDCSIMSLSVLLDYRLEDNKE-H 763
Query: 697 SIEITSILN----------GLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRN 746
S E++ G++ +S E+ED++ + D K++ + D R+
Sbjct: 764 SFEVSLFAELFNEMLQRDFGVRIYKSLLSLPEKEDKK---EKDKKSKKDERKDK-KEERD 819
Query: 747 DLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKD 806
D + + ++ D K K + + D E ++ E D + + +
Sbjct: 820 DETDEPKPKRRKSGDDKDKKEDRDERKKEDKRKDDSKDDDETEEDNNQDEYDPMEAEEAE 879
Query: 807 VKKDTTDKS--SKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNK 849
++D D+ +K KR RYC P K +EK K +
Sbjct: 880 DEEDDRDEEEMTKRDDKRDINRYCKER-------PSKDKEKEKTQ 917
>gi|4885193 AT rich interactive domain 3A (BRIGHT- like) protein
[Homo sapiens]
Length = 593
Score = 72.0 bits (175), Expect = 3e-12
Identities = 30/87 (34%), Positives = 56/87 (64%)
Query: 308 ERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQ 367
+R+ FL L+ FM+ RGTP+N+ P++ + L+LF L+ LV + GG + + +W+++ +
Sbjct: 240 KRKEFLDDLFSFMQKRGTPVNRIPIMAKQVLDLFMLYVLVTEKGGLVEVINKKLWREITK 299
Query: 368 DLGIPVLNSAAGYNVKCAYKKYLYGFE 394
L +P ++A + ++ Y KYLY +E
Sbjct: 300 GLNLPTSITSAAFTLRTQYMKYLYPYE 326
Score = 40.8 bits (94), Expect = 0.009
Identities = 19/46 (41%), Positives = 30/46 (65%)
Query: 527 SGDETNKEEDEDDEEAEEEEEEEEEEEDEDDDDNNEEEEFECYPPG 572
+ DE K + E++E E+ E+EEEEE++ +D+ EE+E PPG
Sbjct: 118 ASDEDMKPKWEEEEMEEDLGEDEEEEEEDYEDEEEEEDEEGLGPPG 163
Score = 38.9 bits (89), Expect = 0.033
Identities = 16/39 (41%), Positives = 27/39 (69%)
Query: 520 AEEEKAKSGDETNKEEDEDDEEAEEEEEEEEEEEDEDDD 558
++E+ +E EED ++E EEEE+ E+EEE+ED++
Sbjct: 119 SDEDMKPKWEEEEMEEDLGEDEEEEEEDYEDEEEEEDEE 157
Score = 36.2 bits (82), Expect = 0.21
Identities = 19/40 (47%), Positives = 27/40 (67%), Gaps = 2/40 (5%)
Query: 511 DESLNIKVEAEEEKAKSGDETNKEEDEDDEEAEEEEEEEE 550
DE + K E EE + G++ +EE+E+D E EEEEE+EE
Sbjct: 120 DEDMKPKWEEEEMEEDLGED--EEEEEEDYEDEEEEEDEE 157
Score = 35.8 bits (81), Expect = 0.28
Identities = 16/40 (40%), Positives = 27/40 (67%)
Query: 520 AEEEKAKSGDETNKEEDEDDEEAEEEEEEEEEEEDEDDDD 559
A +E K E + E++ E+ EEEEE+ E+EE+E+D++
Sbjct: 118 ASDEDMKPKWEEEEMEEDLGEDEEEEEEDYEDEEEEEDEE 157
Score = 35.4 bits (80), Expect = 0.36
Identities = 16/38 (42%), Positives = 25/38 (65%)
Query: 530 ETNKEEDEDDEEAEEEEEEEEEEEDEDDDDNNEEEEFE 567
E + E+ DE+ + + EEEE EED +D+ EEE++E
Sbjct: 111 EEHFEDMASDEDMKPKWEEEEMEEDLGEDEEEEEEDYE 148
Score = 33.5 bits (75), Expect = 1.4
Identities = 19/36 (52%), Positives = 22/36 (61%), Gaps = 3/36 (8%)
Query: 271 EDSSSSEAEEEEEE---EDDEKEKEDNSSEEEEEIE 303
ED EEE EE ED+E+E+ED EEEEE E
Sbjct: 121 EDMKPKWEEEEMEEDLGEDEEEEEEDYEDEEEEEDE 156
Score = 33.1 bits (74), Expect = 1.8
Identities = 13/29 (44%), Positives = 20/29 (68%)
Query: 265 WKTELKEDSSSSEAEEEEEEEDDEKEKED 293
W+ E E+ + EEEEE+ +DE+E+ED
Sbjct: 127 WEEEEMEEDLGEDEEEEEEDYEDEEEEED 155
Score = 31.6 bits (70), Expect = 5.2
Identities = 12/26 (46%), Positives = 20/26 (76%)
Query: 268 ELKEDSSSSEAEEEEEEEDDEKEKED 293
E++ED E EEEE+ ED+E+E+++
Sbjct: 131 EMEEDLGEDEEEEEEDYEDEEEEEDE 156
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 70.1 bits (170), Expect = 1e-11
Identities = 90/435 (20%), Positives = 175/435 (40%), Gaps = 55/435 (12%)
Query: 410 EKVVNKQCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSL 469
E+ K+ +E ++++K KEE ET K+ ++E EE+ ++ ++ + P+
Sbjct: 237 ERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQR-KFEEETVKSKVTVDTGVIPAS 295
Query: 470 GSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDD-----------TTRVDESLNIKV 518
K PT ++ + E + KK + + +K++ T + + K+
Sbjct: 296 EEKAET----PTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKL 351
Query: 519 EAEEEKAKSGDETNKEEDEDDEEAEEEEEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVR 578
+ EEE+ K +E + E+ E +EEE E+E+ E +E + G K+ +
Sbjct: 352 KEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEG-KLLTK 410
Query: 579 YGRGKNQKMYEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHR 638
R + EA++K +G EV K P + + + K R
Sbjct: 411 SQREARARA-EATLKLLQAQGVEV------------------PSKDSLPKKRPIYEDKKR 451
Query: 639 KKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSP-EMVSKLDLTDAKNSDTAHIKS 697
KKI +L+ ++ + ++ P + P P E + D DA D + S
Sbjct: 452 KKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMAS 511
Query: 698 IEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSS 757
E T + G + E+ E+E+E ++ ++ EE + + E + S
Sbjct: 512 DEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEE----------EGESEGSE 561
Query: 758 SLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSK 817
E+ KV + K + K P + +S D++Y+ D+ K + + K
Sbjct: 562 GDEEDEKVSDEKDSGKTLDKKPSK------EMSSDSEYDSDDDRTKEERAYDKAKRRIEK 615
Query: 818 PQIKRGKRRYCNTEE 832
+++ K NTE+
Sbjct: 616 RRLEHSKN--VNTEK 628
Score = 59.7 bits (143), Expect = 2e-08
Identities = 125/643 (19%), Positives = 242/643 (37%), Gaps = 81/643 (12%)
Query: 543 EEEEEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGGEV 602
++++ + E+ +D D + E E + + + +GK +K K D + ++
Sbjct: 3 KKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKK----EKKKQDFDEDDI 58
Query: 603 LYLVHYCGWNVRYDEWIKADK---IVRPADKN----VPKIKHRKKIKNKLDKEKDKD-EK 654
L + + IKAD+ V+P + N K K +K K K D D E+
Sbjct: 59 LKELEELSLEA---QGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEE 115
Query: 655 YSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSA 714
K+ K ++ +KP EM S D D N K + SE
Sbjct: 116 LEDKDSKSKKTAKPKV------EMYSGSDDDDDFNKLPKKAKG-KAQKSNKKWDGSEEDE 168
Query: 715 EDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKP 774
++S++ ER ++++G+ + D +R ++ +E D
Sbjct: 169 DNSKKIKERSR--INSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIK 226
Query: 775 VSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECL 834
+ +K+ E D EE +K K+ ++ T K + + K +R++ EE +
Sbjct: 227 TVAQKKAEKKERERKKRD---EEKAKLRKLKEKEELETGKKDQSKQKESQRKF--EEETV 281
Query: 835 K------TGSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKS 888
K TG EEKA+ ++ ED+ E K KK G +E+++
Sbjct: 282 KSKVTVDTGVIPASEEKAETP-----------TAAEDDNEGDKKKKDKKKKKGEKEEKEK 330
Query: 889 LRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSD 948
+ G + ++ + L +ER + ++ ++ ++ K+ +E
Sbjct: 331 EKKKGPSKATVKAMQEALAKLKEEEER----QKREEEERIKRLEELEAKRKEEERLEQEK 386
Query: 949 TEAAASPPHPAPEEGVAEESLQTVAEEES---CSPSVELEKPPPVNVDSKP-IEEKTVEV 1004
E E E L T ++ E+ +++L + V V SK + +K
Sbjct: 387 RERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIY 446
Query: 1005 NDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRS-IKS 1063
D+K + P+ S V+E ++V V E P +EE ++
Sbjct: 447 EDKKRK--------------KIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEP 492
Query: 1064 ETDSTIEV------DSVAGELQDLQSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQK 1117
E + E +++A + + + EGN V + + E E E+ +
Sbjct: 493 EEEEDTEDAGLDDWEAMASDEETEKVEGNK----VHIEVKENPEEEEEEEEEEEEDEESE 548
Query: 1118 RVKDAQGGGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSA 1160
++ +G S+ + K V + K GK + S+E+S+
Sbjct: 549 EEEEEEGESEGSEGDEEDEK--VSDEKDSGKTLDKKPSKEMSS 589
Score = 59.3 bits (142), Expect = 2e-08
Identities = 144/697 (20%), Positives = 260/697 (37%), Gaps = 126/697 (18%)
Query: 266 KTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKF-MEDRG 324
K ++ D+ ++E E ++ E +K ++E++ + F E+ + L++L + +E +G
Sbjct: 14 KDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDED--DILKELEELSLEAQG 71
Query: 325 TPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKC 384
++ V N + F K + G KQ + D L + K
Sbjct: 72 IKADRETVAVKPTENNEEEFTSKDKK---KKGQKGK--KQSFDDNDSEELEDKDSKSKKT 126
Query: 385 AYKKYLYGFEEYCRSANIEFQMALPEKVVNKQCKECENVKEIKVKEENETEIKEIKMEEE 444
A K E Y S + + LP+K K K + K+ EE+E K+IK E
Sbjct: 127 AKPKV----EMYSGSDDDDDFNKLPKKAKGKAQK---SNKKWDGSEEDEDNSKKIK---E 176
Query: 445 RNIIPREEKPIEDEIERKENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKD 504
R+ R E E E ++ G KKN KP N ++D
Sbjct: 177 RS---RINSSGESGDESDEFLQSRKGQKKN---------------QKNKPGPNIESGNED 218
Query: 505 DDTT-RVDESLNIKVEAEEEKAKSGDETNKEEDEDDEEAEEEEEEEEEEEDEDDDDNNEE 563
DD + ++ K E +E + K+ DE+ + + +E+EE E + D +E
Sbjct: 219 DDASFKIKTVAQKKAEKKERE-------RKKRDEEKAKLRKLKEKEELETGKKDQSKQKE 271
Query: 564 EEFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIKADK 623
+ + +K +V G E KA+
Sbjct: 272 SQRKFEEETVKSKVTVDTGVIPASEE------------------------------KAET 301
Query: 624 IVRPADKNVPKIKHRKKIKNKLDK-EKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKL 682
D N K + K K K +K EK+K++K P ++ + + + E
Sbjct: 302 PTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEER---- 357
Query: 683 DLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLT 742
K + IK +E E +E+ER Q+ K++ K
Sbjct: 358 ----QKREEEERIKRLE-------------ELEAKRKEEERLEQEKRERKKQKEK----- 395
Query: 743 NNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTK 802
R + + KE + + E + A+ + ++ E KD + + YE+ K
Sbjct: 396 -ERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKD-SLPKKRPIYED----K 449
Query: 803 KRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKE-------EKAKNKESLCME 855
KRK + + K ++ C E ++ G P K+E E+ ++ E ++
Sbjct: 450 KRKKIPQQLESKEVSESME-----LCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLD 504
Query: 856 NSSNSSSDEDEEETKA-KMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDE 914
+ +SDE+ E+ + K+ K N EE+ + E E+ + DE
Sbjct: 505 DWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDE 564
Query: 915 RLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEA 951
++ + D KD ++ KK KE+ SDS+ ++
Sbjct: 565 --EDEKVSDEKDSGKTLD----KKPSKEMSSDSEYDS 595
Score = 57.8 bits (138), Expect = 7e-08
Identities = 139/640 (21%), Positives = 234/640 (36%), Gaps = 94/640 (14%)
Query: 492 KKPEDNENLDDKDDDTTRVD-ESLNIKVEAEEEKAKSGDETNKEE---DEDDEEAEEEEE 547
K ++ DD D D + E E E +K+K + K++ DEDD E EE
Sbjct: 6 KNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEEL 65
Query: 548 EEEEEEDEDDDD-------NNEEEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGG 600
E + + D + N EEEF + + K QK + S D+D E
Sbjct: 66 SLEAQGIKADRETVAVKPTENNEEEFTS---------KDKKKKGQKGKKQSFDDNDSEEL 116
Query: 601 EVLYLVHYCGWNVRYDEWIKADKIVRP-------ADKNVPKIKHRKKIKNKLDKEKDK-- 651
E D+ K+ K +P +D + K KK K K K K
Sbjct: 117 E--------------DKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWD 162
Query: 652 ----DEKYSPKNCKLRRLSKPPFQTNPSPEMVS--KLDLTDAKNSDTAHIKS--IEITSI 703
DE S K + R++ + S E + K + KN +I+S + +
Sbjct: 163 GSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDAS 222
Query: 704 LNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEEN 763
++ AE E+E ++ ++ K + K + T ++ KE Q EE
Sbjct: 223 FKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRK---FEEE 279
Query: 764 KVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKR- 822
V + + + V + E + + +ED ++E KK+KD KK +K K + K+
Sbjct: 280 TVKSKVTVDTGVIPASEE-KAETPTAAED----DNEGDKKKKDKKKKKGEKEEKEKEKKK 334
Query: 823 --GKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYN 880
K +E L ++EE+ K +E ++ + EEE + +K
Sbjct: 335 GPSKATVKAMQEAL--AKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQ 392
Query: 881 GLEEKRKSLRTTGFYSGFSE-----VAEKRIKLLNNSDERL--QNSRAKDRKDVWSSIQG 933
+E+++ L+ G S+ AE +KLL + ++S K R +
Sbjct: 393 KEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRK 452
Query: 934 QWPKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPV--- 990
+ P++ + S+S AA E Q V E+E P VE E+
Sbjct: 453 KIPQQLESKEVSESMELCAA-----------VEVMEQGVPEKEETPPPVEPEEEEDTEDA 501
Query: 991 ---NVDSKPIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVTV 1047
+ ++ +E+T +V K V P E E S ++
Sbjct: 502 GLDDWEAMASDEETEKVEGNKVHI------EVKENPEEEEEEEEEEEEDEESEEEEEEEG 555
Query: 1048 SEPLAPNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGNS 1087
+ EE + E DS +D + SE +S
Sbjct: 556 ESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDS 595
Score = 36.2 bits (82), Expect = 0.21
Identities = 16/41 (39%), Positives = 25/41 (60%)
Query: 261 IPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEE 301
+ N + E +E+ E EE EEEE++E E E + +EE+E
Sbjct: 527 VKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDE 567
Score = 32.3 bits (72), Expect = 3.1
Identities = 18/50 (36%), Positives = 27/50 (54%), Gaps = 5/50 (10%)
Query: 262 PANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEEREN 311
P + E +E+ E+EEEEEEE E SE +EE E +E+++
Sbjct: 531 PEEEEEEEEEEEEDEESEEEEEEEG-----ESEGSEGDEEDEKVSDEKDS 575
>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
Length = 1564
Score = 70.1 bits (170), Expect = 1e-11
Identities = 152/795 (19%), Positives = 294/795 (36%), Gaps = 110/795 (13%)
Query: 429 KEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSK-KNLLESIPTHSDQEK 487
+ E + ++ + ++R P + DE+ER E + + + + D+E+
Sbjct: 624 RRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRER 683
Query: 488 EVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGD-ETNKEEDEDDEEAEEEE 546
E + ++ + E D++ + R E + E E E+ K D E +++ D D E E E
Sbjct: 684 ERDRERERERERERDREREKERELERERAR-EREREREKERDRERDRDRDHDRERERERE 742
Query: 547 EEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGGEVLYLV 606
+ E+E + + ++ E E E R + ++ A +D + E
Sbjct: 743 RDREKEREREREERERERERE---------RERERERERERERARERDKERE-------- 785
Query: 607 HYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLS 666
R +W DK + + R++I+ + DE+ S K + R
Sbjct: 786 -------RQRDWEDKDK------GRDDRREKREEIREDRNPRDGHDERKSKK--RYRNEG 830
Query: 667 KPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERG-- 724
P + +P D +DA NS + + S + Q S S + ED +G
Sbjct: 831 SPSPRQSPKRRREHSPD-SDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRW 889
Query: 725 -AQDMDNNGKEESKIDHLTNNRNDLISKEEQ-NSSSLLEENKVHADLVISKPVSKSPERL 782
+D KE S+ + + S ++Q + +LE +++ A +I S+
Sbjct: 890 KEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSED---- 945
Query: 783 RKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKP-QIKRGKRRYCNTEECLKTGSPGK 841
E +D DE KK K KK K I+RG T E + SP K
Sbjct: 946 -------RETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIE--TTSEDGQVFSP-K 995
Query: 842 KEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEV 901
K +K K+ E ++ +S ++E ++K K++ RT
Sbjct: 996 KGQKKKSIEKKRKKSKGDSDISDEEAAQQSK------------KKRGPRTPPI-----TT 1038
Query: 902 AEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPE 961
E+ +++ N + L++S+ K+ + W + + + ++ E A+ P
Sbjct: 1039 KEELVEMCNGKNGILEDSQKKE-----DTAFSDWSDEDVPDRTEVTEAEHTATATTP--- 1090
Query: 962 EGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVLN 1021
G L ++ L PPPV + T+ A S S ++
Sbjct: 1091 -GSTPSPLSSL-----------LPPPPPVATATATTVPATLAATTAAAATSFSTSAITIS 1138
Query: 1022 TPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQDL 1081
T T + ++ E S ++ T R K ET D+ + D
Sbjct: 1139 TSATPTNTTNNTFANEDSHRKCHRT------------RVEKVETPHVTIEDAQHRKPMDQ 1186
Query: 1082 QSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRS-----H 1136
+ + + S +S P + ++ Q K GS +++ +S
Sbjct: 1187 KRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGE 1246
Query: 1137 KATVVNNKKKGKGTNSSDSE-ELSAGESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCG 1195
+ + ++ K+G+ + S+ S+ + S S +S P +S S S R Q +
Sbjct: 1247 RKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYE 1306
Query: 1196 KNGDKDPDLKEPSNR 1210
+ +++ + ++ R
Sbjct: 1307 HDRERERERRDTRQR 1321
Score = 56.6 bits (135), Expect = 2e-07
Identities = 98/495 (19%), Positives = 186/495 (37%), Gaps = 76/495 (15%)
Query: 409 PEKVVNKQCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPS 468
P + Q + E ++ + +E + + + E R E+ E E ER+
Sbjct: 641 PSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDRE 700
Query: 469 LGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSG 528
++ L ++E+E + D + D++ + R + + EE+ +
Sbjct: 701 REKERELERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERER 760
Query: 529 DETNKEEDEDDEEAEEEEEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMY 588
+ + E E + E E E ++E E + D ++ ++ GR ++
Sbjct: 761 ERERERERERERERERARERDKERERQRDWEDKDK----------------GRDDRREKR 804
Query: 589 EASIKDSDVEGGEVLYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKE 648
E +D + G +DE K+ K R P+ +++ ++ D +
Sbjct: 805 EEIREDRNPRDG--------------HDE-RKSKKRYRNEGSPSPRQSPKRRREHSPDSD 849
Query: 649 -----KDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSI 703
DK+EK+ L ++ +P + SP +++ K D
Sbjct: 850 AYNSGDDKNEKHR----LLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKP--------- 896
Query: 704 LNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLI----SKEEQNSSSL 759
+ ESS EQE + +D ++ ++ D+I S++ + S
Sbjct: 897 ----ERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRA 952
Query: 760 LEENKVHADLVISKPVSKSPER----LRKDIEVLSEDTDYEEDEVTKKRKDVKK------ 809
+ENK A + KP+ K E R +IE SED + +K+K ++K
Sbjct: 953 HDENKKKAK-IQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSK 1011
Query: 810 ---DTTDKSSKPQI--KRGKRR-YCNTEECLKTGSPGKKE--EKAKNKESLCMENSSNSS 861
D +D+ + Q KRG R T+E L GK E ++ KE + S+
Sbjct: 1012 GDSDISDEEAAQQSKKKRGPRTPPITTKEELVEMCNGKNGILEDSQKKEDTAFSDWSDED 1071
Query: 862 SDEDEEETKAKMTPT 876
+ E T+A+ T T
Sbjct: 1072 VPDRTEVTEAEHTAT 1086
Score = 49.7 bits (117), Expect = 2e-05
Identities = 116/729 (15%), Positives = 262/729 (35%), Gaps = 92/729 (12%)
Query: 421 ENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLESIP 480
E+ + + +E++ E +E + ++ + R+++ D +R++ ++ L +S
Sbjct: 418 EDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRD--ARDTRDRRELRDSRD 475
Query: 481 THSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGDETNKEEDEDDE 540
+E+ + E+ D +D +TR +A + + + G +T+++ED E
Sbjct: 476 MRDS--REMRDYSRDTKESRDPRDSRSTR---------DAHDYRDREGRDTHRKEDTYPE 524
Query: 541 EAEEEEEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGG 600
E+ EE + NE + ++R R + + + G
Sbjct: 525 ESRSYGRNHLREESSRTEIRNESRN------ESRSEIRNDRMGRSRGRVPELPEKGSRGS 578
Query: 601 EVLYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNC 660
+ + + +D W + P P+ +R + ++ + + +
Sbjct: 579 RGSQIDSHSSNSNYHDSW--ETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRE 636
Query: 661 KLRRLSKPPFQTNPSPEM-------VSKLDLTDAKNSDTAHIKSIE-------------- 699
+ +R S P + E+ ++D D + + A + E
Sbjct: 637 RDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERERE 696
Query: 700 ---ITSILNGLQASESSAEDSEQEDERGAQ-----DMDNNGKEESKIDHLTNNRNDLISK 751
L+ + + E+E ER + D D + E + D + +
Sbjct: 697 RDREREKERELERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREER 756
Query: 752 EEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDT 811
E + E + + ++ K ER R ED D D+ +KR+++++D
Sbjct: 757 ERERERERERERERERERERARERDKERERQRD-----WEDKDKGRDDRREKREEIREDR 811
Query: 812 TDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKA 871
+ + ++ K+RY N GSP ++ + +E ++ NS D++E+
Sbjct: 812 NPRDGHDE-RKSKKRYRN------EGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLL 864
Query: 872 KMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKDVWSSI 931
++ +SL S +E + R K + ER ++SR + +++ +
Sbjct: 865 SQVVR------PQESRSLSP----SHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKV 914
Query: 932 QGQWPKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPVN 991
++ E+ S A H +E+ S E
Sbjct: 915 SSVDKQREQTEILESSRMRAQDIIGHHQ-------------SEDRETSDRAHDENKKKAK 961
Query: 992 VDSKPIEEKTV-EVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEP 1050
+ KPI++K +V + ++ + + +P + S + S+ S ++ E
Sbjct: 962 IQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDIS-DEE 1020
Query: 1051 LAPNQEEVRSIKSETDSTIE-----VDSVAGELQDLQSEGNSSPAGFDASVSSSSSNQPE 1105
A ++ R ++ +T E + G L+D Q + +++ + + + E
Sbjct: 1021 AAQQSKKKRGPRTPPITTKEELVEMCNGKNGILEDSQKKEDTAFSDWSDEDVPDRTEVTE 1080
Query: 1106 PEHPEKACT 1114
EH A T
Sbjct: 1081 AEHTATATT 1089
Score = 38.1 bits (87), Expect = 0.056
Identities = 65/329 (19%), Positives = 123/329 (37%), Gaps = 46/329 (13%)
Query: 710 SESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADL 769
+E S+ +E RG + KE+ KI ++ + E + + + ++ D
Sbjct: 105 TEESSSPVRKESSRGR----HREKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDY 160
Query: 770 VISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCN 829
V + +++++++ L ++ + +E+ K++ + K S R +
Sbjct: 161 VHELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPK 220
Query: 830 TEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPT------------K 877
+ K+ S KK+ K S ++ NS +++ ++ K TP+ K
Sbjct: 221 RKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKK--KGPRTPSPPPPIPEDIALGK 278
Query: 878 KY-------NGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDR-----K 925
KY + +EEK + + G F EKR K + S +S R
Sbjct: 279 KYKEKYKVKDRIEEKTRDGKDRG--RDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSS 336
Query: 926 DVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELE 985
SSIQ P K S S + +PP SL + ++S
Sbjct: 337 QSGSSIQRHSPSPRRKRTPSPS-YQRTLTPPLRRSASPYPSHSLSSPQRKQS-------- 387
Query: 986 KPP----PVNVDSKPIEEKTVEVNDRKAE 1010
PP P+ + E+T + +DR+ E
Sbjct: 388 -PPRHRSPMREKGRHDHERTSQSHDRRHE 415
Score = 35.4 bits (80), Expect = 0.36
Identities = 77/463 (16%), Positives = 168/463 (36%), Gaps = 45/463 (9%)
Query: 424 KEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGS-KKNLLESIPTH 482
++IK+ +E E +E +E E N + I + + +++ ++ L++ +
Sbjct: 125 EDIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQEN 184
Query: 483 SDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGDETNKEEDEDDE-E 541
++ +E+ IKK E + K + S +++ ++ K KS +++ +D +
Sbjct: 185 MEKREEIIIKKEVSPEVVRSK------LSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTS 238
Query: 542 AEEEEEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKM-----YEASIKDSD 596
A +++ + + + PP + + G+ +K E +D
Sbjct: 239 AVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGK 298
Query: 597 VEGGEVLYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYS 656
G + R E + PA ++ I R + + S
Sbjct: 299 DRGRDF----------ERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPS 348
Query: 657 PKNCKL-----RRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASE 711
P+ + +R PP + + SP L K S H + + + S+
Sbjct: 349 PRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQ 408
Query: 712 SSAEDSEQ-EDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLV 770
S E+ ED RG +D + + +EE + + ++ D E + + D
Sbjct: 409 SHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRD-- 466
Query: 771 ISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNT 830
+ R +D+ E DY D TK+ +D + + + + R R
Sbjct: 467 ------RRELRDSRDMRDSREMRDYSRD--TKESRDPRDSRSTRDAHDYRDREGRDTHRK 518
Query: 831 EECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKM 873
E+ +E ++ + L E+S +E E+++++
Sbjct: 519 EDTY------PEESRSYGRNHLREESSRTEIRNESRNESRSEI 555
Score = 35.0 bits (79), Expect = 0.47
Identities = 39/195 (20%), Positives = 77/195 (39%), Gaps = 19/195 (9%)
Query: 410 EKVVNKQCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKP-- 467
++V++ ++ E K +++ E ++ I ++K E + + R+ + +
Sbjct: 1225 KRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDR 1284
Query: 468 -------SLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEA 520
S S+ L E D+E+E + E D D D R + ++ E
Sbjct: 1285 QVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLR-ER 1343
Query: 521 EEEKAKSGDETNKEEDEDDEEAEEEEEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYG 580
E E+ E +K D D E + E + D D D E + E +K
Sbjct: 1344 ERER-----ERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIE----SVKRCEAKL 1394
Query: 581 RGKNQKMYEASIKDS 595
G++++ E++ +DS
Sbjct: 1395 EGEHERDLESTSRDS 1409
>gi|55956788 nucleolin [Homo sapiens]
Length = 710
Score = 68.9 bits (167), Expect = 3e-11
Identities = 46/156 (29%), Positives = 81/156 (51%), Gaps = 21/156 (13%)
Query: 437 KEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPED 496
KE EEE + +E+ EDE E ++ I+P+ + P D++ E +D
Sbjct: 142 KEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAA---MKAAAAAPASEDEDDE------DD 192
Query: 497 NENLDDKDDDTTRVDESLNIKVEAEEEKA------KSGDETNKEEDEDDEEAEEEEEEEE 550
++ DD DD+ +E A+ +KA K+ + E++E+D+E E+++++E+
Sbjct: 193 EDDEDDDDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEEDDEDEDDDDDED 252
Query: 551 EEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQK 586
+E+D+D+DD EEEE E P V+ GK +K
Sbjct: 253 DEDDDDEDDEEEEEEEEEEP------VKEAPGKRKK 282
Score = 57.0 bits (136), Expect = 1e-07
Identities = 107/484 (22%), Positives = 189/484 (39%), Gaps = 51/484 (10%)
Query: 486 EKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGDETNKEEDEDDEEAEEE 545
+KE + ++ +D+ D++DD+ DE E E K+ EDEDDE
Sbjct: 141 KKEDSDEEEDDDSEEDEEDDEDEDEDED-----EIEPAAMKAAAAAPASEDEDDE----- 190
Query: 546 EEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGGEVLYL 605
++E++E++D+D++D++EEE E P K + K + + E ++ D E +
Sbjct: 191 DDEDDEDDDDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEEDDEDEDDDDD 250
Query: 606 VHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRL 665
+ DE + ++ P K P + ++ K K E K + + L
Sbjct: 251 EDDEDDDDEDDEEEEEEEEEEPV-KEAPGKRKKEMAKQKAAPEAKKQKVEGTEPTTAFNL 309
Query: 666 SKPPFQTNPS-PEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERG 724
N S PE+ + + AKN D A + + I SAED E+ E
Sbjct: 310 FVGNLNFNKSAPELKTGISDVFAKN-DLA-VVDVRIGMTRKFGYVDFESAEDLEKALELT 367
Query: 725 AQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRK 784
+ N E K++ SK+E+++ +LL +N P + + L++
Sbjct: 368 GLKVFGN---EIKLEKPKGKD----SKKERDARTLLAKN---------LPYKVTQDELKE 411
Query: 785 DIEVLSEDTDYEEDEVTKKRKDVK-KDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKE 843
E +E +D +K ++ K D + K+G + TG G+ +
Sbjct: 412 VFEDAAEIRLVSKDGKSKGIAYIEFKTEADAEKTFEEKQGTEIDGRSISLYYTGEKGQNQ 471
Query: 844 EKAKNKES--------LCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFY 895
+ K S L + N S S+++E +E K T K K K F
Sbjct: 472 DYRGGKNSTWSGESKTLVLSNLSYSATEETLQEVFEKATFIKVPQNQNGKSKGYAFIEFA 531
Query: 896 S-----------GFSEVAEKRIKLLNNSDERLQNSRAKDRKDVW-SSIQGQWPKKTLKEL 943
S E+ + I+L N+R++ K ++ + ++TLKE
Sbjct: 532 SFEDAKEALNSCNKREIEGRAIRLELQGPRGSPNARSQPSKTLFVKGLSEDTTEETLKES 591
Query: 944 FSDS 947
F S
Sbjct: 592 FDGS 595
Score = 52.0 bits (123), Expect = 4e-06
Identities = 30/126 (23%), Positives = 58/126 (46%), Gaps = 27/126 (21%)
Query: 467 PSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAK 526
P+ G+K ++E + + + ED+E+ D+ +D+ A E++
Sbjct: 130 PAKGAKNGKNAKKEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAAAPASEDEDD 189
Query: 527 SGDETNKEEDEDDEEAEEE---------------------------EEEEEEEEDEDDDD 559
DE ++++D+D+E+ EE E+EEE++EDEDDDD
Sbjct: 190 EDDEDDEDDDDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEEDDEDEDDDD 249
Query: 560 NNEEEE 565
+ ++E+
Sbjct: 250 DEDDED 255
Score = 47.8 bits (112), Expect = 7e-05
Identities = 43/168 (25%), Positives = 67/168 (39%), Gaps = 9/168 (5%)
Query: 141 NRGRRSNHIPEEESSSSSSDEDEDDRKQIDELLGKVVCVDYISLDKKKALWFPALVVCPD 200
N+G P + S+++E + D+ G+ V + K A +VV P
Sbjct: 10 NQGDPKKMAPPPKEVEEDSEDEEMSEDEEDDSSGEEVVIPQKKGKKAAATSAKKVVVSPT 69
Query: 201 CSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTAPKPDAVLKQAFEQALEFHKSRT 260
+A V K T +K V + T P A K
Sbjct: 70 KKVAVATPAKKAAVTPGKKAAATPA-KKTVTPAKAVTTPGKKGATPGKALVATPGKKGAA 128
Query: 261 IPA----NWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEP 304
IPA N K KEDS E ++ EE+E+D+++++ E+E+EIEP
Sbjct: 129 IPAKGAKNGKNAKKEDSDEEEDDDSEEDEEDDEDED----EDEDEIEP 172
Score = 45.8 bits (107), Expect = 3e-04
Identities = 42/211 (19%), Positives = 77/211 (36%), Gaps = 30/211 (14%)
Query: 134 PVIGKKTNRGRRSNHIPEEESSSSSSDEDEDDRKQIDELLGKVVCVDYISLDKKKALWFP 193
P G K + + EEE S DE++D+ + DE D+ +
Sbjct: 130 PAKGAKNGKNAKKEDSDEEEDDDSEEDEEDDEDEDEDE-------------DEIEPAAMK 176
Query: 194 ALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTAPKPDAVLKQAFEQAL 253
A P DE ++ D D E +T P +
Sbjct: 177 AAAAAPASEDEDDEDDED-------DEDDDDDEEDDSEEEAMETTPAKGKKAAKVVPV-- 227
Query: 254 EFHKSRTIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFL 313
K++ + + E ++ + +E++E++DDE ++E+ EEEE ++ P +R+ +
Sbjct: 228 ---KAKNVAEDEDEEEDDEDEDDDDDEDDEDDDDEDDEEEEEEEEEEPVKEAPGKRKKEM 284
Query: 314 QQLYKFMEDRGTPINKRPVLGYRNLNLFKLF 344
+ + K+ V G F LF
Sbjct: 285 AK-----QKAAPEAKKQKVEGTEPTTAFNLF 310
Score = 40.8 bits (94), Expect = 0.009
Identities = 100/476 (21%), Positives = 179/476 (37%), Gaps = 61/476 (12%)
Query: 524 KAKSGDETNKEEDEDDEEAEEEEEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGR-- 581
KA K+ +E EE+ E+EE EDE+DD + EE G K +
Sbjct: 6 KAGKNQGDPKKMAPPPKEVEEDSEDEEMSEDEEDDSSG-EEVVIPQKKGKKAAATSAKKV 64
Query: 582 --GKNQKMYEAS-IKDSDVEGGEVLYLVHYCGWNVRYDEWIKADKIVRPADK-NVPKIKH 637
+K+ A+ K + V G+ A K V PA P K
Sbjct: 65 VVSPTKKVAVATPAKKAAVTPGKKAAAT-------------PAKKTVTPAKAVTTPGKKG 111
Query: 638 RKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKS 697
K + K K K + +K ++ + S+ D D ++ D
Sbjct: 112 ATPGKALVATPGKKGAAIPAKGAKNGKNAKKE-DSDEEEDDDSEEDEEDDEDEDE---DE 167
Query: 698 IEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSS 757
EI A+ ++ED + ED+ +D D++ +++S EE+
Sbjct: 168 DEIEPAAMKAAAAAPASEDEDDEDDEDDEDDDDDEEDDS---------------EEEAME 212
Query: 758 SLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSK 817
+ + K A +V K + + + ++ + +D D E+DE D +++ ++
Sbjct: 213 TTPAKGKKAAKVVPVKAKNVAEDEDEEEDDEDEDDDDDEDDEDDDDEDDEEEEEEEEEEP 272
Query: 818 PQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMEN--SSNSSSDEDEEETKAKMTP 875
+ GKR+ E + +P K++K + E N N + ++ E K ++
Sbjct: 273 VKEAPGKRK---KEMAKQKAAPEAKKQKVEGTEPTTAFNLFVGNLNFNKSAPELKTGISD 329
Query: 876 TKKYNGLE--EKRKSLRTTGFYSGF--SEVAEKRIKLLN----NSDERLQNSRAKDRK-- 925
N L + R + Y F +E EK ++L ++ +L+ + KD K
Sbjct: 330 VFAKNDLAVVDVRIGMTRKFGYVDFESAEDLEKALELTGLKVFGNEIKLEKPKGKDSKKE 389
Query: 926 -DVWSSIQGQWPKKT----LKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEE 976
D + + P K LKE+F D+ S +G+A +T A+ E
Sbjct: 390 RDARTLLAKNLPYKVTQDELKEVFEDAAEIRLVS--KDGKSKGIAYIEFKTEADAE 443
Score = 34.3 bits (77), Expect = 0.81
Identities = 34/120 (28%), Positives = 48/120 (40%), Gaps = 14/120 (11%)
Query: 186 KKKALWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTAPKPDAVL 245
KK A ALV P K I + K+GK D E + D
Sbjct: 109 KKGATPGKALVATP------GKKGAAIPAKGAKNGKNAKKEDSDEEEDDDSEEDEEDDED 162
Query: 246 KQAFEQALEFHKSRTIPANWKTELKEDSSSSEAEEEEEE-EDDEKEKEDNSSEEEEEIEP 304
+ E +E PA K +S E +E++E+ EDD+ ++ED+S EE E P
Sbjct: 163 EDEDEDEIE-------PAAMKAAAAAPASEDEDDEDDEDDEDDDDDEEDDSEEEAMETTP 215
Score = 32.7 bits (73), Expect = 2.3
Identities = 25/103 (24%), Positives = 41/103 (39%), Gaps = 3/103 (2%)
Query: 1093 DASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATVVNNKKKGKGTNS 1152
D+ S ++ + E+ QK+ K A + + K V KK T
Sbjct: 27 DSEDEEMSEDEEDDSSGEEVVIPQKKGKKAAATSAKKVVVSPTKKVAVATPAKKAAVTPG 86
Query: 1153 SDSEELSAGESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCG 1195
+ A +++T P K+V+T K +T A +PGK G
Sbjct: 87 KKAAATPAKKTVT---PAKAVTTPGKKGATPGKALVATPGKKG 126
>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
Length = 4374
Score = 68.9 bits (167), Expect = 3e-11
Identities = 39/137 (28%), Positives = 68/137 (49%), Gaps = 2/137 (1%)
Query: 431 ENETEIKEIKMEEERNIIPREEKPIEDEIERK-ENIKPSLGSKKNLLESIPTHSDQEKEV 489
+ E E + + + ++ +E +E+E+E + + G N + + E +
Sbjct: 2320 DGEAETDSVVIAGQPEVLSSQEMQVENELEDLIDELLERDGGSGNSTIIVSRSGEDESQE 2379
Query: 490 NIKKPEDNENLDDKDDDTTRVDESLNI-KVEAEEEKAKSGDETNKEEDEDDEEAEEEEEE 548
++ E NL ++S+NI E EEE + D + EDEDD + EEEEEE
Sbjct: 2380 DVLMDEAPSNLSQASTLQANREDSMNILDPEDEEEHTQEEDSSGSNEDEDDSQDEEEEEE 2439
Query: 549 EEEEEDEDDDDNNEEEE 565
E+EE+D++DD+ E +E
Sbjct: 2440 EDEEDDQEDDEGEEGDE 2456
Score = 40.0 bits (92), Expect = 0.015
Identities = 17/31 (54%), Positives = 23/31 (74%)
Query: 271 EDSSSSEAEEEEEEEDDEKEKEDNSSEEEEE 301
ED S+ EEEEEEED+E ++ED+ EE +E
Sbjct: 2426 EDEDDSQDEEEEEEEDEEDDQEDDEGEEGDE 2456
Score = 37.4 bits (85), Expect = 0.095
Identities = 56/262 (21%), Positives = 87/262 (33%), Gaps = 25/262 (9%)
Query: 913 DERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTV 972
DE L+ R K RK + K + D + AS + + E+ +++ +
Sbjct: 2683 DEELEERREKRRKQLAEEETKITDKGKEDKENRDQSAQCTASKSNDSTEQNLSDGT---- 2738
Query: 973 AEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSS 1032
P + P + D+ E K + SS L TPP E P
Sbjct: 2739 -------PMPDSYPTTPSSTDAATSESK-----ETLGTLQSSQQQPTLPTPPALGEVPQE 2786
Query: 1033 VTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGNSSPAGF 1092
+ G SS + P+ P + E ++T S A + L E
Sbjct: 2787 LQSPAGEGG-SSTQLLMPVEPEELGPTRPSGEAETTQMELSPAPTITSLSPERAEDSDAL 2845
Query: 1093 DASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRSH-------KATVVNNKK 1145
A VSS P +CT ++ V D GSS + + S V +
Sbjct: 2846 TA-VSSQLEGSPMDTSSLASCTLEEAVGDTSAAGSSEQPRAGSSTPGDAPPAVAEVQGRS 2904
Query: 1146 KGKGTNSSDSEELSAGESITKS 1167
G G ++ E+ S S S
Sbjct: 2905 DGSGESAQPPEDSSPPASSESS 2926
Score = 36.6 bits (83), Expect = 0.16
Identities = 38/201 (18%), Positives = 86/201 (42%), Gaps = 16/201 (7%)
Query: 118 ETLDQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDEDEDDRKQIDEL---LG 174
ETL ++ FG+ K N+ + ++SSS+ D E ++ E +
Sbjct: 2251 ETLSRIVNQPSSLFGSKSASSK-NKSEQDAQGASQDSSSNQQDPGEPGEAEVQEEDHDVT 2309
Query: 175 KVVCVDYISLDKKKALWFPALVVCPDC--SDEIAVKK------DNILVRSFKDGKFTSVP 226
+ D +D + + P+ S E+ V+ D +L R G T +
Sbjct: 2310 QTEVADGDIMDGEAETDSVVIAGQPEVLSSQEMQVENELEDLIDELLERDGGSGNSTIIV 2369
Query: 227 RKDVHEITSDTAPKPDAVLKQAFEQALEFHKSRTI----PANWKTELKEDSSSSEAEEEE 282
+ + + + +A + L+ ++ ++ P + + +E+ SS E+E+
Sbjct: 2370 SRSGEDESQEDVLMDEAPSNLSQASTLQANREDSMNILDPEDEEEHTQEEDSSGSNEDED 2429
Query: 283 EEEDDEKEKEDNSSEEEEEIE 303
+ +D+E+E+E++ +++E+ E
Sbjct: 2430 DSQDEEEEEEEDEEDDQEDDE 2450
Score = 36.6 bits (83), Expect = 0.16
Identities = 14/34 (41%), Positives = 24/34 (70%)
Query: 268 ELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEE 301
E ++DS E EEEE+EEDD+++ E +E+++
Sbjct: 2426 EDEDDSQDEEEEEEEDEEDDQEDDEGEEGDEDDD 2459
Score = 35.4 bits (80), Expect = 0.36
Identities = 43/207 (20%), Positives = 87/207 (42%), Gaps = 20/207 (9%)
Query: 682 LDLTDAKNSDT--AHIKSIEITS-ILNGLQA-----SESSAEDSEQEDERGAQDMDNNGK 733
LDL+ ++T A +K +E S I+N + S SS SEQ+ + +QD +N +
Sbjct: 2232 LDLSSPNMANTVNAALKPLETLSRIVNQPSSLFGSKSASSKNKSEQDAQGASQDSSSNQQ 2291
Query: 734 E--ESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLR-----KDI 786
+ E + +D+ E + + E + + ++ +P S + ++ +D+
Sbjct: 2292 DPGEPGEAEVQEEDHDVTQTEVADGDIMDGEAETDSVVIAGQPEVLSSQEMQVENELEDL 2351
Query: 787 --EVLSEDTDYEEDEVTKKRK---DVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGK 841
E+L D + R + ++D + + + N E+ + P
Sbjct: 2352 IDELLERDGGSGNSTIIVSRSGEDESQEDVLMDEAPSNLSQASTLQANREDSMNILDPED 2411
Query: 842 KEEKAKNKESLCMENSSNSSSDEDEEE 868
+EE + ++S + S DE+EEE
Sbjct: 2412 EEEHTQEEDSSGSNEDEDDSQDEEEEE 2438
Score = 33.5 bits (75), Expect = 1.4
Identities = 25/102 (24%), Positives = 43/102 (42%), Gaps = 17/102 (16%)
Query: 474 NLLESIPTHSDQEKEVNIKKPEDNE-----------NLDDKDDDTTRVDESLNIKVEAEE 522
NL ++ +++E +NI PED E N D+ D +E + + + E+
Sbjct: 2389 NLSQASTLQANREDSMNILDPEDEEEHTQEEDSSGSNEDEDDSQDEEEEEEEDEEDDQED 2448
Query: 523 EKAKSGDE------TNKEEDEDDEEAEEEEEEEEEEEDEDDD 558
++ + GDE + E DED + E D +DD
Sbjct: 2449 DEGEEGDEDDDDDGSEMELDEDYPDMNASPLVRFERFDREDD 2490
Score = 32.3 bits (72), Expect = 3.1
Identities = 12/41 (29%), Positives = 26/41 (63%)
Query: 270 KEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERE 310
+++ S + EEEEEE++++ +++D E +E+ + E E
Sbjct: 2426 EDEDDSQDEEEEEEEDEEDDQEDDEGEEGDEDDDDDGSEME 2466
Score = 31.6 bits (70), Expect = 5.2
Identities = 63/293 (21%), Positives = 115/293 (39%), Gaps = 28/293 (9%)
Query: 821 KRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEE-----TKAKMTP 875
+R KRR EE K GK++++ +++ + C + SN S++++ + TP
Sbjct: 2689 RREKRRKQLAEEETKITDKGKEDKENRDQSAQCTASKSNDSTEQNLSDGTPMPDSYPTTP 2748
Query: 876 TKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQW 935
+ E +++L T S + L + LQ+ + SS Q
Sbjct: 2749 SSTDAATSESKETLGT--LQSSQQQPTLPTPPALGEVPQELQSPAGEG----GSSTQLLM 2802
Query: 936 PKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSP-SVELEKPPPVNVDS 994
P + + + EA + +P + S + + ++ + S +LE P +D+
Sbjct: 2803 PVEPEELGPTRPSGEAETTQMELSPAPTITSLSPERAEDSDALTAVSSQLEGSP---MDT 2859
Query: 995 KPIEEKTVE--VNDRKA----EFPSSGSNSVLNTPPTTPE----SPSSVTVTEGSRQQSS 1044
+ T+E V D A E P +GS++ + PP E S S + S
Sbjct: 2860 SSLASCTLEEAVGDTSAAGSSEQPRAGSSTPGDAPPAVAEVQGRSDGSGESAQPPEDSSP 2919
Query: 1045 VTVSEPLAPNQEEVRSIKSETDSTIE--VDSVAGELQDLQSEGNSSPAGFDAS 1095
SE + V +++ +E + S + E +D G S P G D S
Sbjct: 2920 PASSESSSTRDSAVAISGADSRGILEEPLPSTSSEEED-PLAGISLPEGVDPS 2971
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 67.0 bits (162), Expect = 1e-10
Identities = 101/557 (18%), Positives = 229/557 (41%), Gaps = 70/557 (12%)
Query: 402 IEFQMALPEKVVNKQCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIER 461
++ +M E+ + +Q K+ +E ++E +E KM E+ + R+EK + ++ +
Sbjct: 270 LQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKE 329
Query: 462 KENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESL---NIKV 518
+ L +K L E +Q +E K E E + ++++ R +E L ++
Sbjct: 330 LREQEKELREQKELRE----QEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQM 385
Query: 519 EAEEEKAKSGDETNKEEDEDDEEAEEEEEEEE------EEEDEDDDDNNEEEEFECYPPG 572
+E+K + +E E+DE E EE E+E E+ E+ +E++
Sbjct: 386 REQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEK 445
Query: 573 MKVQVRYGRGKNQKMYEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIKADKIVRPADKNV 632
M+ + R R + +KM E +++ E E + W EW + ++ +K
Sbjct: 446 MQEEERI-REREKKMREE--EETMREQEEKMQKQEENMWEQEEKEW-QQQRLPEQKEKLW 501
Query: 633 PKIK---HRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKN 689
+ K +KI + +K +D++E + + K+ R K Q + E K+ + K
Sbjct: 502 EQEKMQEQEEKIWEQEEKIRDQEEMWGQEK-KMWRQEKMREQEDQMWEQEEKMRDQEQKM 560
Query: 690 SDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLI 749
D E E QE E+ D + +EE ++ R +
Sbjct: 561 WD------------------QEERMEKKTQEQEKKTWDQEEKMREEERM----REREKKM 598
Query: 750 SKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKK 809
+EE+ ++ E + + + + E++++ E+ +E++E +++++
Sbjct: 599 REEEE----MMREQE--------EKMQEQEEKMQE-----QEEKMWEQEEKMQEQEEKMW 641
Query: 810 DTTDKSSKPQIKR-GKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEE 868
+ +K + + K ++R +E L +++EK + +E E +++E+
Sbjct: 642 EQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEK 701
Query: 869 TKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRA---KDRK 925
++ + E+ K +R E+ ++ + + +E++Q + +
Sbjct: 702 KTWDQEKMREEESMREREKKMREE------EEMMREQEEKMQEQEEKMQEQEEEMWEQEE 755
Query: 926 DVWSSIQGQWPKKTLKE 942
+W + W ++ L E
Sbjct: 756 KMWEQEEKMWEQQRLPE 772
Score = 60.8 bits (146), Expect = 8e-09
Identities = 84/417 (20%), Positives = 169/417 (40%), Gaps = 62/417 (14%)
Query: 270 KEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEI----EPFPEERENFLQQLYKFMEDRGT 325
+++ + + EE+ +EE+ +E+E EEEE + E ++ EN +Q K + +
Sbjct: 434 EQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRL 493
Query: 326 PINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCA 385
P K + + + +W+Q K
Sbjct: 494 PEQKEKLWEQEKMQE----------------QEEKIWEQ----------------EEKIR 521
Query: 386 YKKYLYGFEEYC----RSANIEFQMALPEKVVNKQCKECENVKEIKVKEENETEIK---- 437
++ ++G E+ + E QM E+ + Q ++ + +E K+ E E K
Sbjct: 522 DQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQ 581
Query: 438 EIKMEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDN 497
E KM EE + RE+K E+E +E + ++ + E +QE+ K E
Sbjct: 582 EEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEE----KMQEQE 637
Query: 498 ENLDDKDDDTTRVDESLNIKVEAEEEKAKSGDETNKEEDEDDEEAE---------EEEEE 548
E + ++++ +E + + E+K K + +E E +E E E++ +
Sbjct: 638 EKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQ 697
Query: 549 EEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGGEVLYLVHY 608
E+E++ D + EEE M+ + R + +KM E K + E E ++
Sbjct: 698 EQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQE--EEMWEQEE 755
Query: 609 CGWNVRYDEWIKADKIVRPADK--NVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLR 663
W W + ++ +K K++ ++KI + +K +D++EK + K+R
Sbjct: 756 KMWEQEEKMW-EQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMR 811
Score = 50.1 bits (118), Expect = 1e-05
Identities = 69/355 (19%), Positives = 146/355 (41%), Gaps = 50/355 (14%)
Query: 246 KQAFEQALEFHKSRTIPANWKTELKEDSSSSEAEEEEEEEDDE-KEKEDNSSEEEEEI-- 302
K+ ++Q + + + K +E+ E EE+ +E++++ +E+E+ E+EE++
Sbjct: 576 KKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQE 635
Query: 303 --EPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGA 360
E E+ E +Q K E + P K + + + + + +
Sbjct: 636 QEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQ----------EQEEK 685
Query: 361 VWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQMALPEKVVNKQCKEC 420
+W+Q +K +E + + +M E + ++ K
Sbjct: 686 IWEQ----------------------EKMEKKTQEQEKKTWDQEKMREEESMREREKKMR 723
Query: 421 ENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLESIP 480
E + ++ +EE E +E E+E + +EEK E E + E + L +K L
Sbjct: 724 EEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWE--QQRLPEQKEKLWEHE 781
Query: 481 THSDQEK--EVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEK-----AKSGDETNK 533
+QEK E K + E + +++ +E K+ +EEK K + K
Sbjct: 782 KMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEE----KMRGQEEKMWGQEEKMWGQEEK 837
Query: 534 EEDEDDEEAEEEEEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMY 588
++++ +EE+ EE+ + +++ +EE+ M+ Q RG+ +K+Y
Sbjct: 838 MWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKIY 892
Score = 47.4 bits (111), Expect = 9e-05
Identities = 75/409 (18%), Positives = 157/409 (38%), Gaps = 84/409 (20%)
Query: 266 KTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGT 325
K +++ + + EE+ EE+ +E+E EEEE + E+ E +Q K E
Sbjct: 569 KKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMR---EQEEKMQEQEEKMQEQEEK 625
Query: 326 PINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQ---VYQDLGIPVLNSAAGYNV 382
+ + + +++ + +W+Q +++ +P
Sbjct: 626 MWEQEEKMQEQEEKMWE--------------QEEKMWEQEEKMWEQQRLP---------- 661
Query: 383 KCAYKKYLYGFEEYCRSANIEFQMALPEKVVNKQCKECENVK-EIKVKEENETEIKEIKM 441
K+ L+ E+ M EK+ ++ K E K E K +E+ + + KM
Sbjct: 662 --EQKEKLWEHEK----------MQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKM 709
Query: 442 EEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLD 501
EE ++ RE+K E+E E + ++ +E K E E +
Sbjct: 710 REEESMREREKKMREEE------------------EMMREQEEKMQEQEEKMQEQEEEMW 751
Query: 502 DKDDDTTRVDESLNIKVEAEEEKAKSGDETNKEEDEDDEEAEEEEEEEEEEEDEDDDDNN 561
++++ +E + + E+K K + +E E E EE+ ++EE+
Sbjct: 752 EQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKM------RG 805
Query: 562 EEEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIKA 621
+EE+ M+ Q G+ +KM+ K W W +
Sbjct: 806 QEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEK----------------MWGQEEKMWGQE 849
Query: 622 DKIVRPADKNVPKIKHR-KKIKNKLDKEKDKDEKYSPKNCKLRRLSKPP 669
+K+ K++ + +K++ + +K ++++EK + K+ + PP
Sbjct: 850 EKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKIYCVGSPP 898
Score = 43.5 bits (101), Expect = 0.001
Identities = 115/657 (17%), Positives = 241/657 (36%), Gaps = 84/657 (12%)
Query: 430 EENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLESIPTHSDQEKEV 489
EE E + +E RN I EE +K+N + L E +P ++ E+
Sbjct: 200 EELTKERDALSLELYRNTITNEEL-------KKKNAE--------LQEKLPLAESEKSEI 244
Query: 490 NIKKPEDNENLDDKDDDTTRVDESL-NIKVEAEEEKAKSGDETNKEEDEDDEEAEEEEEE 548
+ E L+ R L ++ +E+ +E +E+++ + EE+
Sbjct: 245 QLNVKELKRKLE-------RAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWR 297
Query: 549 EEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGGEVLYLVHY 608
+EE E + E+EE + + K + E +++ + E E L
Sbjct: 298 QEERLREQEGKMREQEE-----------KMWRQEKRLREQEKELREQEKELREQKELREQ 346
Query: 609 CGWNVRYDE--WIKADKIVRPADKNVPKIKHR-----KKIKNKLDKEKDKDEKYSPKNCK 661
+E W + +K +R ++ + + + R K+++ + K +D++E+ ++ +
Sbjct: 347 EEQMQEQEEKMWEQEEK-MREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDER 405
Query: 662 LRRLSKPPFQTNPSPEMV------SKLDLTDAKNSDTAHIKSIE--ITSILNGLQASESS 713
LR + + E V K+ + K D E I ++ E +
Sbjct: 406 LREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEET 465
Query: 714 AEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKE---EQNSSSLLEENKVHADLV 770
+ E++ ++ ++M ++E + L + L +E EQ +E K+
Sbjct: 466 MREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQ-- 523
Query: 771 ISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNT 830
+ + + R++ ED +E++E + ++ D ++ K ++ K+ +
Sbjct: 524 -EEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQE 582
Query: 831 EECLKTGSPGKKEEKAKNKESLCMENSSNSSSDED----------EEETKAKMTPTKKYN 880
E+ + ++E+K + +E + E E+ E+E K + K +
Sbjct: 583 EKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMW- 641
Query: 881 GLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTL 940
E++ K + E++ KL + + Q + + +W Q + KKT
Sbjct: 642 --EQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWE--QEKMEKKTQ 697
Query: 941 KELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEK 1000
++ D E E E + + E+E E EK + EEK
Sbjct: 698 EQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQE-EKMQEQEEEMWEQEEK 756
Query: 1001 TVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEE 1057
E ++ E PE + E ++Q + E +QEE
Sbjct: 757 MWEQEEKMWE------------QQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEE 801
>gi|104526627 triadin [Homo sapiens]
Length = 729
Score = 67.0 bits (162), Expect = 1e-10
Identities = 131/619 (21%), Positives = 239/619 (38%), Gaps = 90/619 (14%)
Query: 490 NIKKPEDNENLD-DKDDDTTRVDESLNIKVEAEEEKAKSGDE---------TNKEEDEDD 539
+I ED E+ D D+D D +DE K E ++K + ++ T+KE+++
Sbjct: 112 DIISSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGK 171
Query: 540 EEAEEEEEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEG 599
E+ E+E+ E++ ++ + E+ E + K + K + E K +V+G
Sbjct: 172 EKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQK------KAKTAEKSEEKTK-KEVKG 224
Query: 600 GEVLYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKN 659
G K +K+ + A K K K K K DKEK K+ K+
Sbjct: 225 G-------------------KQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKD 265
Query: 660 CKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQ 719
Q M+ D K + I T + + + E+ E
Sbjct: 266 -----------QYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEG 314
Query: 720 EDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSP 779
E ++ + + + K++ K D + + E+ E K + ++ +K
Sbjct: 315 EKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKD 374
Query: 780 ERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSK-----PQIKRGKRRYCNTEE-- 832
E+ ++D + + + E+ + K+ K K KS K P K+ K + +E
Sbjct: 375 EK-KEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEI 433
Query: 833 ---CLKTGSPGKKEEKAKN--KESLCMENSSNSSSD-EDEEETKAKMTPTKKYNGLEEKR 886
+K PGKKEEK ++ + E S +SS +D+E K K K L+EK
Sbjct: 434 GAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGK--EEKVPASLKEKE 491
Query: 887 -KSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFS 945
++ + EV K +L +E+ + K+ K S ++
Sbjct: 492 PETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISE---------KVQIHK 542
Query: 946 DSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELE------KPPPVNVDS-KPIE 998
+ + H PEE V ++ ++ V E++ P + +PP + D KP
Sbjct: 543 QDIVKPEKTVSHGKPEEKVLKQ-VKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTP 601
Query: 999 EKTVEVND---RKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEP---LA 1052
+ T EV + +K E S + E V+ + S Q +VT +E ++
Sbjct: 602 KGTSEVTESGKKKTEISEKESKEKADMKHLREE---KVSTRKESLQLHNVTKAEKPARVS 658
Query: 1053 PNQEEVRSIKSETDSTIEV 1071
+ E+V + K + T +V
Sbjct: 659 KDVEDVPASKKAKEGTEDV 677
Score = 57.4 bits (137), Expect = 9e-08
Identities = 104/555 (18%), Positives = 213/555 (38%), Gaps = 83/555 (14%)
Query: 746 NDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRK 805
+D+IS E++ E+ I +P + E + E + + +VT K K
Sbjct: 111 SDIISSEDEEDDDGDEDTDKGE---IDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEK 167
Query: 806 DVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDED 865
+ K+ + KP+ K + +E +T + K+++KAK ++++
Sbjct: 168 EKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAK-------------TAEKS 214
Query: 866 EEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRK 925
EE+TK ++ G +EK K + EV + K D+ ++K
Sbjct: 215 EEKTKKEVK-----GGKQEKVKQTA-----AKVKEVQKTPSKPKEKEDKEKAAVSKHEQK 264
Query: 926 DVWSSIQGQWPKKTLKELFSDSDTEAAASP--PHPAPEEGVAEESLQTVAEEESCSPSVE 983
D ++ + + ++F D + SP P P P E + + + A EE +
Sbjct: 265 DQYAFC------RYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKK 318
Query: 984 LEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQS 1043
EK V ++K E++ ++ K + ++ P S +Q
Sbjct: 319 AEK--KVTSETKKKEKEDIKKKSEK--------ETAIDVEKKEPGKASET-------KQG 361
Query: 1044 SVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGNSSPAGF---DASVSSSS 1100
+V ++ A ++E + +T EV+ G+ Q+ + E + PA + SV S
Sbjct: 362 TVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQE-KKEKHVEPAKSPKKEHSVPSDK 420
Query: 1101 SNQPEPEHP---------EKACTGQKRVKDAQGGGSSSKKQKRSHKATVVNNKKKGKGTN 1151
+ + E +KA G+K K + +K+K ++++ +K+ KG
Sbjct: 421 QVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKE 480
Query: 1152 SSDSEELSAGESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDKDPDLKEPS--- 1208
L E TK S K+ P Q GK K +P +K+ +
Sbjct: 481 EKVPASLKEKEPETKKDEKMS-----KAGKEVKPKPPQLQGK--KEEKPEPQIKKEAKPA 533
Query: 1209 -NRLPKVYKWSFQMSDLENMTSAERITILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKK 1267
+ +++K +++ E+ + +++ K ++ E + + K+ + +
Sbjct: 534 ISEKVQIHK--------QDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHR 585
Query: 1268 ERESAATSSSSSSPS 1282
ERE + + P+
Sbjct: 586 EREPPSIKTDKPKPT 600
Score = 45.1 bits (105), Expect = 5e-04
Identities = 125/640 (19%), Positives = 237/640 (37%), Gaps = 109/640 (17%)
Query: 440 KMEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNEN 499
K E ++ ++EKP ERK K + K+ E + +EKE KK E
Sbjct: 140 KKEIHKDKTEKQEKP-----ERKIQTKVTHKEKEKGKEKV-----REKEKPEKKATHKEK 189
Query: 500 LDDKDDDTTRVDESLNIKVEAEEEKAKSGD---ETNKEEDEDDEEAEEEEEEEEEEEDED 556
++ K+ T+ + E++KAK+ + E K+E + ++ + ++ + +E +
Sbjct: 190 IEKKEKPETKT-------LAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQK 242
Query: 557 DDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGGEVLYLVHYCGWNVRYD 616
+E+E + K V K+Q + + D V G G +
Sbjct: 243 TPSKPKEKEDK-----EKAAVSKHEQKDQYAFCRYMIDIFVHGD------LKPGQSPAIP 291
Query: 617 EWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSP 676
+ ++ RP + P ++ ++ K K +K+ + K K
Sbjct: 292 PPLPTEQASRPTPAS-PALEEKEGEKKKAEKKVTSETKKKEKE-----------DIKKKS 339
Query: 677 EMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEES 736
E + +D+ + + K + + EDS++ + + K+E
Sbjct: 340 EKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEK 399
Query: 737 KIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYE 796
K H+ + + S +E+ V +D K V ER +++I +S
Sbjct: 400 KEKHV------------EPAKSPKKEHSVPSD----KQVKAKTERAKEEIGAVS------ 437
Query: 797 EDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMEN 856
+ K K++ T K+ + +I++ E+ KT S K +E K K E
Sbjct: 438 ---IKKAVPGKKEEKTTKTVEQEIRK--------EKSGKTSSILKDKEPIKGK-----EE 481
Query: 857 SSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNS--DE 914
+S E E ETK +K G E K K + G E E +IK E
Sbjct: 482 KVPASLKEKEPETKKDEKMSKA--GKEVKPKPPQLQG---KKEEKPEPQIKKEAKPAISE 536
Query: 915 RLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAE 974
++Q + K + G+ +K LK++ + + + A P E
Sbjct: 537 KVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAE------------H 584
Query: 975 EESCSPSVELEKPPPVNVDSKPIEE---KTVEVNDRKAEFPSSGSNSVLNTPPTTPESPS 1031
E PS++ +KP P + + E K E+++++++ + + T ES
Sbjct: 585 REREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQ 644
Query: 1032 SVTVTEG------SRQQSSVTVSEPLAPNQEEVRSIKSET 1065
VT+ S+ V S+ E+V K ++
Sbjct: 645 LHNVTKAEKPARVSKDVEDVPASKKAKEGTEDVSPTKQKS 684
Score = 43.1 bits (100), Expect = 0.002
Identities = 134/678 (19%), Positives = 241/678 (35%), Gaps = 141/678 (20%)
Query: 415 KQCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSKKN 474
K+ + + K+ K + + +T++ + E+ + + +EKP E + KE I+ KK
Sbjct: 141 KEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKP-EKKATHKEKIE-----KKE 194
Query: 475 LLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGDETNKE 534
E+ +Q+K +K E+ + K +V ++ E ++ +K ++ +KE
Sbjct: 195 KPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKE 254
Query: 535 EDEDDEEAEEEE----------------------------EEEEEEEDEDDDDNNEEEEF 566
+ + ++++ E+ EE+E
Sbjct: 255 KAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEG 314
Query: 567 ECYPPGMKVQVRYGRGKNQKMYEASIKDS--DVEGGEVLYLVHYCGWNVRYDEWIKADKI 624
E KV + + + + + S K++ DVE E V+
Sbjct: 315 EKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKI--------A 366
Query: 625 VRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDL 684
+ A K K + KK K + E+ K +K K + P + + + K
Sbjct: 367 AQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKT 426
Query: 685 TDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNN 744
AK I ++ I + G + E + + EQE + + +GK S + +
Sbjct: 427 ERAKE----EIGAVSIKKAVPG-KKEEKTTKTVEQEIRK-----EKSGKTSS----ILKD 472
Query: 745 RNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRK-DIEVLSEDTDYEEDEVTKK 803
+ + KEE KV A L +P +K E++ K EV + + + K
Sbjct: 473 KEPIKGKEE----------KVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKP 522
Query: 804 RKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKA-KNKESLCMENSSNSSS 862
+KK+ S+ +++ K+ E KT S GK EEK K +++ +E +
Sbjct: 523 EPQIKKEAKPAISE-KVQIHKQDIVKPE---KTVSHGKPEEKVLKQVKAVTIEKT----- 573
Query: 863 DEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAK 922
AK PTKK E + S++T + K
Sbjct: 574 --------AKPKPTKKAEHREREPPSIKT---------------------------DKPK 598
Query: 923 DRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSV 982
S + KKT S+ +++ A H + EE + T E
Sbjct: 599 PTPKGTSEVTESGKKKT---EISEKESKEKADMKH------LREEKVSTRKESLQLHNVT 649
Query: 983 ELEKPPPVNVD------SKPIEEKTVEVNDRKAEFPSSGSNSVL------------NTPP 1024
+ EKP V+ D SK +E T +V+ K + P S V TP
Sbjct: 650 KAEKPARVSKDVEDVPASKKAKEGTEDVSPTKQKSPISFFQCVYLDGYNGYGFQFPFTPA 709
Query: 1025 TTPESPSSVTVTEGSRQQ 1042
P S + G +QQ
Sbjct: 710 DRPGESSGQANSPGQKQQ 727
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 65.9 bits (159), Expect = 3e-10
Identities = 93/477 (19%), Positives = 203/477 (42%), Gaps = 42/477 (8%)
Query: 429 KEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLESIPTHSDQEKE 488
K++ + I+E+ E + + I DE +++N K L K L+ES E +
Sbjct: 188 KKKADRYIEELTKERDALSLELYRNTITDEELKEKNAK--LQEKLQLVES----EKSEIQ 241
Query: 489 VNIKKPE----------DNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGDETNKEEDED 538
+N+K+ + + L + D + +S++ K++A+ E+ + + N++++E
Sbjct: 242 LNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEK 301
Query: 539 DEEAEEEEEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVE 598
EE+ +E EE+ E ++ E+EE ++ Q R + + M+E K E
Sbjct: 302 MWRQEEKIQEWEEKIQEQEEKIREQEE------KIREQEEKMRRQEEMMWEKEEKMRRQE 355
Query: 599 GGEVLYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKD-EKYSP 657
E+++ + W K +KI +K + K R++ + + ++EK ++ EK
Sbjct: 356 --EMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQE 413
Query: 658 KNCKL-RRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAED 716
+ K+ R+ K Q E K+ + K + I+ E + E +
Sbjct: 414 QEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIRE 473
Query: 717 SEQ--EDERGAQDMDNNGKEESKIDHLTNNRNDLISK-EEQNSSSLLEENKVHADLVISK 773
E+ + + + K+E K+ +D K EQ +E K+ +
Sbjct: 474 QEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQ---EE 530
Query: 774 PVSKSPERLRKDIEVLSEDTD---YEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNT 830
+ + E++R+ E++ E + +E+++ ++ K +++ + + +I+ K +
Sbjct: 531 KIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQ 590
Query: 831 EECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDE--EETKAKMTPTKKYNGLEEK 885
EE + ++EEK + +E + E E++ E+ + +K EEK
Sbjct: 591 EEKI-----WEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEK 642
Score = 53.1 bits (126), Expect = 2e-06
Identities = 72/400 (18%), Positives = 163/400 (40%), Gaps = 50/400 (12%)
Query: 265 WKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRG 324
W+ E K + +E+EE+ +++EK E+ E E+E +++ + M ++
Sbjct: 303 WRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKE 362
Query: 325 TPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKC 384
+ + + + K+ L K+ + I +Q + +
Sbjct: 363 EKMRRLEEMMWEKEE--KIRELEEKMHEQEKIREQEEKRQEEEKIR-------------- 406
Query: 385 AYKKYLYGFEEYCRSANIEFQMALPEKVVNKQCKECENVKEIKVKEENETEIKEIKMEEE 444
E+ R EK+ ++ K E K++ +EE E ++I+ EE+
Sbjct: 407 ---------EQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEK 457
Query: 445 RNIIPREEKPIEDEIERKENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKD 504
R +EE ++E R++ K + E I ++ K + E + +++
Sbjct: 458 RQ--EQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQE 515
Query: 505 DDTTRVDESLNIKVEAEEEKAKSGDETNKEEDEDDEEAEEEEEEEEEEEDEDDDDNNEEE 564
+ R +E K+ +EEK + +E +E++E +E EE+ E+EE+ E + +EE
Sbjct: 516 EKMWRQEE----KIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEE 571
Query: 565 EFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIKADKI 624
+ ++ Q R + +K++E K +R E + ++
Sbjct: 572 KIREQEEKIREQKEKIREQEEKIWEQEEK-------------------IREQEEMMQEQE 612
Query: 625 VRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRR 664
+ ++ + +K++ + +K + ++EK + +LR+
Sbjct: 613 EKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQ 652
Score = 43.5 bits (101), Expect = 0.001
Identities = 66/404 (16%), Positives = 167/404 (41%), Gaps = 55/404 (13%)
Query: 416 QCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSKKNL 475
Q +E E + ++E + +E K++E I +E+ I ++ E+ + + ++ +
Sbjct: 284 QVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEM 343
Query: 476 LESIPTHSDQEKEVNIKKPEDNENLDD----KDDDTTRVDESLNIKVEAEEEKAKSGDET 531
+ +++E+ +K E L++ K++ ++E ++ E+EK + +E
Sbjct: 344 MWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMH-----EQEKIREQEEK 398
Query: 532 NKEEDE-DDEEAEEEEEEE---EEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKM 587
+EE++ ++E +E+E + +EE+ + ++ E+E + + K+ + + +K
Sbjct: 399 RQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKR 458
Query: 588 YEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIKADKIVRPAD--KNVPKIKHRKKIKNKL 645
E + + W + +KI + + K+ ++KI+ +
Sbjct: 459 QE------------------------QEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQE 494
Query: 646 DKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILN 705
+K ++EK + K+R + ++ K+ + K + K E ++
Sbjct: 495 EKVWRQEEKMHDQEEKIREQEEKMWRQE------EKIREQEEKIREQEE-KIREQEEMMQ 547
Query: 706 GLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKV 765
+ E+ QE E+ + + ++E KI R EQ +E K+
Sbjct: 548 EQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKI------REQKEKIREQEEKIWEQEEKI 601
Query: 766 HADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKK 809
+ + + E++ + E + E + +++ K R+ +K
Sbjct: 602 REQ---EEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEK 642
Score = 43.5 bits (101), Expect = 0.001
Identities = 37/151 (24%), Positives = 71/151 (47%), Gaps = 6/151 (3%)
Query: 410 EKVVNKQCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERK--ENIKP 467
EK+ ++ K E ++I+ +EE E +E+ E+E + +EEK E E R+ E I+
Sbjct: 516 EKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIRE 575
Query: 468 SLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKS 527
+ E I ++ E K E E + ++++ +E K+ +EEK +
Sbjct: 576 QEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEE----KMCEQEEKMQE 631
Query: 528 GDETNKEEDEDDEEAEEEEEEEEEEEDEDDD 558
+E + ++E E E ++EE+ E +
Sbjct: 632 QEEKMRRQEEKMWEQEVRLRQQEEKMQEHQE 662
Score = 32.0 bits (71), Expect = 4.0
Identities = 30/131 (22%), Positives = 55/131 (41%), Gaps = 21/131 (16%)
Query: 403 EFQMALPEKVVNKQCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERK 462
E +M E+ + +Q K ++I+ +EE E KE E+E I +EEK E E
Sbjct: 550 EEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQE---- 605
Query: 463 ENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESL---NIKVE 519
E + ++ E K E E + ++++ R +E + +++
Sbjct: 606 --------------EMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLR 651
Query: 520 AEEEKAKSGDE 530
+EEK + E
Sbjct: 652 QQEEKMQEHQE 662
Score = 30.8 bits (68), Expect = 8.9
Identities = 31/149 (20%), Positives = 64/149 (42%), Gaps = 29/149 (19%)
Query: 403 EFQMALPEKVVNKQCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERK 462
E M E+ + +Q ++ + ++++ +EE E +E E++ I +EEK E E
Sbjct: 543 EEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQE---- 598
Query: 463 ENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEE 522
E I + +E K E E + ++++ K++ +E
Sbjct: 599 --------------EKIREQEEMMQEQEEKMWEQEEKMCEQEE-----------KMQEQE 633
Query: 523 EKAKSGDETNKEEDEDDEEAEEEEEEEEE 551
EK + +E E++ + EE+ +E +E
Sbjct: 634 EKMRRQEEKMWEQEVRLRQQEEKMQEHQE 662
>gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sapiens]
Length = 1758
Score = 65.9 bits (159), Expect = 3e-10
Identities = 171/903 (18%), Positives = 332/903 (36%), Gaps = 137/903 (15%)
Query: 418 KECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLE 477
KE EN +++ K K EE + E +E + G ++N +
Sbjct: 885 KESENAPGDGKGNKHKKHRKRRKGEESEGFLNPEL------LETSRKSREPTGVEENKTD 938
Query: 478 SIPTHSDQEKEVNIK-KPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGDETNKEED 536
S+ ++ ++ +P D E++ K S++ K + E +K K+ + K ++
Sbjct: 939 SLFVLPSRDDATPVRDEPMDAESITFK---------SVSEKDKRERDKPKAKGDKTKRKN 989
Query: 537 EDDEEAEEEEEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSD 596
+ +++E + + ++ D E PP K + + N K +S KD
Sbjct: 990 DGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEK 1049
Query: 597 VEG------------GEVLYLVHYCGWNVRYDEWIKADKIV-------RPADKNVPKIKH 637
+ G + V Y + +K++K+ +P +KN P
Sbjct: 1050 ITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNK 1109
Query: 638 RKKIKNKLDKEKDKDEKYSPKNCKLRRLS-----KPPFQTNPSPEMVSKLDLTDAKN--S 690
+K K K + EK D+ + + K+ +L KP + P+ K+D T K+ S
Sbjct: 1110 GEKRKRKTE-EKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPD-TEKMDRTPEKDKIS 1167
Query: 691 DTAHIKSIEIT----SILNGLQASESSAEDSEQEDERGAQDMDN--NGKEESKIDHLTNN 744
+A K I++ + + ++ E SE+ + ++ GK K+ +
Sbjct: 1168 LSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGS 1227
Query: 745 RNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSED---------TDY 795
+ L+ +S+ K + V K+ E D +ED + +
Sbjct: 1228 SSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKW 1287
Query: 796 EEDEVTKKRKDVKKDTTDKS-SKPQ--IKRGKRRYCN-TEECLKTGSPGKKEEK-AKNKE 850
++D+ + +DVK S KP IK + N + K P +K +K K+
Sbjct: 1288 DKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVS 1347
Query: 851 SLCMEN---SSNSSSDEDEEETK-------AKMTPTKKYNGLEEKRKS----LRTTGFYS 896
+++ SS +S+ ++ +TK K P K+ N + +++S L G +
Sbjct: 1348 HEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFK 1407
Query: 897 GFSEVAEKRIKLLNNSDERLQNSRAKDRKDV--------------WSSIQGQWPKKTL-- 940
S+ +++ + ++ ++RA KD +SS + + K L
Sbjct: 1408 SLSQSSKEA-----RTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTR 1462
Query: 941 -KELFSDSDTEAAASPPHP-----APEEGVAEESLQTVAEEESCSP-----SVELEKP-- 987
K+ S + A+ P P++G + + P + + ++P
Sbjct: 1463 RKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNE 1522
Query: 988 PPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSV-LNTPPTTPESPSSVTVTEGSRQQSSVT 1046
+VD P +++ V + + SSG+ + + PP T +T G +S+V
Sbjct: 1523 ETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQIT---GQIDKSTV- 1578
Query: 1047 VSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSNQPEP 1106
P + S + +D T E D A E +S+ S+ + + S + S +
Sbjct: 1579 -----KPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKD 1633
Query: 1107 EHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESITK 1166
+ EKA Q G S ++ + ++ G T S S SA +K
Sbjct: 1634 KIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSK 1693
Query: 1167 SQPVKSVSTGMKSHS---------------TKSPARTQSPGKCGKNGDKDPDLKEPSNRL 1211
+ K K H KS K KN DK+ + ++ ++
Sbjct: 1694 KKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKV 1753
Query: 1212 PKV 1214
V
Sbjct: 1754 KSV 1756
Score = 63.2 bits (152), Expect = 2e-09
Identities = 180/817 (22%), Positives = 292/817 (35%), Gaps = 164/817 (20%)
Query: 409 PEKVVNKQCKECEN---VKEIKVKEENETEIKEIKM--EEERNIIPREE-KPIEDEIERK 462
P K +K KE + VKE KVK++ ++K K+ +EE+ P E+ KP++++ E++
Sbjct: 1054 PRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKR 1113
Query: 463 ENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEE 522
+ G K+ ES + + I KP ++ + R E I + A
Sbjct: 1114 KRKTEEKGVDKD-FESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPA 1172
Query: 523 EKAKSGDETNKEEDEDDEEAEEEEEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRG 582
+K K ET K+ + + +E E+ E KV+ +G
Sbjct: 1173 KKIKLNRETGKKIGSTENISNTKEPSEKLESTSS-----------------KVKQEKVKG 1215
Query: 583 KNQKMYEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIK 642
K ++ K + EG LV Y + ++ + + V K
Sbjct: 1216 KVRR------KVTGTEGSSST-LVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNND 1268
Query: 643 N----------------KLDKEKDKDEKYSPKNCK-----------LRRLSKPPFQTNPS 675
N K DK+ + E+ K+ + ++ +S P
Sbjct: 1269 NTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKY 1328
Query: 676 PEMVSKLDLTDAK-NSDTAH-IKSIEITSILNGLQASESSAEDSE----QEDERGAQDMD 729
PE S+ K D +H I E+ S N + + +D + +++ +
Sbjct: 1329 PEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNS 1388
Query: 730 NNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVL 789
++ES +D L N K SS + H S +P R +K
Sbjct: 1389 TQPEKESNLDRLNEQGN---FKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKK----- 1440
Query: 790 SEDTDYEEDEV-TKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGK-KEEKAK 847
TDY+ E + KR+D K + T + P + +G K +EE+
Sbjct: 1441 ---TDYDTREYSSSKRRDEKNELTRRKDSPSRNKDS----------ASGQKNKPREERDL 1487
Query: 848 NKESLCMENSSNSSSDEDEEETKAKMT-PTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRI 906
K+ SNSS D + K T TK+ N E+ KS+ V E R
Sbjct: 1488 PKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPN---EETKSVDKNPCKDREKHVLEARN 1544
Query: 907 KLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLK---------ELFSDSDTEAAASPPH 957
++ ++ L + + I GQ K T+K L SD E +
Sbjct: 1545 NKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFE 1604
Query: 958 PAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSN 1017
P E +E ++ +V EEES N+ SK +++K VE KA+ S +
Sbjct: 1605 PDYNESDSESNV-SVKEEESSG-----------NI-SKDLKDKIVE----KAK-ESLDTA 1646
Query: 1018 SVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGE 1077
+V+ + +S SS SV+ S +P+ + RS S S E
Sbjct: 1647 AVVQVGISRNQSHSS----------PSVSPSRSHSPSGSQTRSHSSSASS--------AE 1688
Query: 1078 LQDLQSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRSHK 1137
QD S + E + +K +K K A K QK HK
Sbjct: 1689 SQD----------------SKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHK 1732
Query: 1138 ATVVNNKKKGKGTNSSDSEELSAGESITKSQPVKSVS 1174
KKK K + D E+ E Q VKSV+
Sbjct: 1733 ------KKKSK--KNKDKEK----EKEKDDQKVKSVT 1757
>gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sapiens]
Length = 1792
Score = 65.9 bits (159), Expect = 3e-10
Identities = 171/903 (18%), Positives = 332/903 (36%), Gaps = 137/903 (15%)
Query: 418 KECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLE 477
KE EN +++ K K EE + E +E + G ++N +
Sbjct: 919 KESENAPGDGKGNKHKKHRKRRKGEESEGFLNPEL------LETSRKSREPTGVEENKTD 972
Query: 478 SIPTHSDQEKEVNIK-KPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGDETNKEED 536
S+ ++ ++ +P D E++ K S++ K + E +K K+ + K ++
Sbjct: 973 SLFVLPSRDDATPVRDEPMDAESITFK---------SVSEKDKRERDKPKAKGDKTKRKN 1023
Query: 537 EDDEEAEEEEEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSD 596
+ +++E + + ++ D E PP K + + N K +S KD
Sbjct: 1024 DGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEK 1083
Query: 597 VEG------------GEVLYLVHYCGWNVRYDEWIKADKIV-------RPADKNVPKIKH 637
+ G + V Y + +K++K+ +P +KN P
Sbjct: 1084 ITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNK 1143
Query: 638 RKKIKNKLDKEKDKDEKYSPKNCKLRRLS-----KPPFQTNPSPEMVSKLDLTDAKN--S 690
+K K K + EK D+ + + K+ +L KP + P+ K+D T K+ S
Sbjct: 1144 GEKRKRKTE-EKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPD-TEKMDRTPEKDKIS 1201
Query: 691 DTAHIKSIEIT----SILNGLQASESSAEDSEQEDERGAQDMDN--NGKEESKIDHLTNN 744
+A K I++ + + ++ E SE+ + ++ GK K+ +
Sbjct: 1202 LSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGS 1261
Query: 745 RNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSED---------TDY 795
+ L+ +S+ K + V K+ E D +ED + +
Sbjct: 1262 SSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKW 1321
Query: 796 EEDEVTKKRKDVKKDTTDKS-SKPQ--IKRGKRRYCN-TEECLKTGSPGKKEEK-AKNKE 850
++D+ + +DVK S KP IK + N + K P +K +K K+
Sbjct: 1322 DKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVS 1381
Query: 851 SLCMEN---SSNSSSDEDEEETK-------AKMTPTKKYNGLEEKRKS----LRTTGFYS 896
+++ SS +S+ ++ +TK K P K+ N + +++S L G +
Sbjct: 1382 HEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFK 1441
Query: 897 GFSEVAEKRIKLLNNSDERLQNSRAKDRKDV--------------WSSIQGQWPKKTL-- 940
S+ +++ + ++ ++RA KD +SS + + K L
Sbjct: 1442 SLSQSSKEA-----RTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTR 1496
Query: 941 -KELFSDSDTEAAASPPHP-----APEEGVAEESLQTVAEEESCSP-----SVELEKP-- 987
K+ S + A+ P P++G + + P + + ++P
Sbjct: 1497 RKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNE 1556
Query: 988 PPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSV-LNTPPTTPESPSSVTVTEGSRQQSSVT 1046
+VD P +++ V + + SSG+ + + PP T +T G +S+V
Sbjct: 1557 ETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQIT---GQIDKSTV- 1612
Query: 1047 VSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSNQPEP 1106
P + S + +D T E D A E +S+ S+ + + S + S +
Sbjct: 1613 -----KPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKD 1667
Query: 1107 EHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESITK 1166
+ EKA Q G S ++ + ++ G T S S SA +K
Sbjct: 1668 KIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSK 1727
Query: 1167 SQPVKSVSTGMKSHS---------------TKSPARTQSPGKCGKNGDKDPDLKEPSNRL 1211
+ K K H KS K KN DK+ + ++ ++
Sbjct: 1728 KKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKV 1787
Query: 1212 PKV 1214
V
Sbjct: 1788 KSV 1790
Score = 63.2 bits (152), Expect = 2e-09
Identities = 180/817 (22%), Positives = 292/817 (35%), Gaps = 164/817 (20%)
Query: 409 PEKVVNKQCKECEN---VKEIKVKEENETEIKEIKM--EEERNIIPREE-KPIEDEIERK 462
P K +K KE + VKE KVK++ ++K K+ +EE+ P E+ KP++++ E++
Sbjct: 1088 PRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKR 1147
Query: 463 ENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEE 522
+ G K+ ES + + I KP ++ + R E I + A
Sbjct: 1148 KRKTEEKGVDKD-FESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPA 1206
Query: 523 EKAKSGDETNKEEDEDDEEAEEEEEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRG 582
+K K ET K+ + + +E E+ E KV+ +G
Sbjct: 1207 KKIKLNRETGKKIGSTENISNTKEPSEKLESTSS-----------------KVKQEKVKG 1249
Query: 583 KNQKMYEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIK 642
K ++ K + EG LV Y + ++ + + V K
Sbjct: 1250 KVRR------KVTGTEGSSST-LVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNND 1302
Query: 643 N----------------KLDKEKDKDEKYSPKNCK-----------LRRLSKPPFQTNPS 675
N K DK+ + E+ K+ + ++ +S P
Sbjct: 1303 NTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKY 1362
Query: 676 PEMVSKLDLTDAK-NSDTAH-IKSIEITSILNGLQASESSAEDSE----QEDERGAQDMD 729
PE S+ K D +H I E+ S N + + +D + +++ +
Sbjct: 1363 PEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNS 1422
Query: 730 NNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVL 789
++ES +D L N K SS + H S +P R +K
Sbjct: 1423 TQPEKESNLDRLNEQGN---FKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKK----- 1474
Query: 790 SEDTDYEEDEV-TKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGK-KEEKAK 847
TDY+ E + KR+D K + T + P + +G K +EE+
Sbjct: 1475 ---TDYDTREYSSSKRRDEKNELTRRKDSPSRNKDS----------ASGQKNKPREERDL 1521
Query: 848 NKESLCMENSSNSSSDEDEEETKAKMT-PTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRI 906
K+ SNSS D + K T TK+ N E+ KS+ V E R
Sbjct: 1522 PKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPN---EETKSVDKNPCKDREKHVLEARN 1578
Query: 907 KLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLK---------ELFSDSDTEAAASPPH 957
++ ++ L + + I GQ K T+K L SD E +
Sbjct: 1579 NKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFE 1638
Query: 958 PAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSN 1017
P E +E ++ +V EEES N+ SK +++K VE KA+ S +
Sbjct: 1639 PDYNESDSESNV-SVKEEESSG-----------NI-SKDLKDKIVE----KAK-ESLDTA 1680
Query: 1018 SVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGE 1077
+V+ + +S SS SV+ S +P+ + RS S S E
Sbjct: 1681 AVVQVGISRNQSHSS----------PSVSPSRSHSPSGSQTRSHSSSASS--------AE 1722
Query: 1078 LQDLQSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRSHK 1137
QD S + E + +K +K K A K QK HK
Sbjct: 1723 SQD----------------SKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHK 1766
Query: 1138 ATVVNNKKKGKGTNSSDSEELSAGESITKSQPVKSVS 1174
KKK K + D E+ E Q VKSV+
Sbjct: 1767 ------KKKSK--KNKDKEK----EKEKDDQKVKSVT 1791
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.304 0.124 0.338
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,436,386
Number of Sequences: 37866
Number of extensions: 3045218
Number of successful extensions: 92004
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 965
Number of HSP's successfully gapped in prelim test: 1163
Number of HSP's that attempted gapping in prelim test: 24276
Number of HSP's gapped (non-prelim): 33226
length of query: 1312
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1198
effective length of database: 13,930,794
effective search space: 16689091212
effective search space used: 16689091212
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.