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Search of human proteins with 115334677
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|115334677 retinoblastoma-binding protein 1 isoform I [Homo
sapiens]
(1257 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|115334677 retinoblastoma-binding protein 1 isoform I [Homo sa... 2488 0.0
gi|115334673 retinoblastoma-binding protein 1 isoform II [Homo s... 2328 0.0
gi|115334679 retinoblastoma-binding protein 1 isoform III [Homo ... 2189 0.0
gi|22035677 AT rich interactive domain 4B isoform 1 [Homo sapiens] 925 0.0
gi|22035679 AT rich interactive domain 4B isoform 2 [Homo sapiens] 773 0.0
gi|5453638 AT rich interactive domain 3B [Homo sapiens] 85 4e-16
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 84 6e-16
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 84 6e-16
gi|62865637 AT rich interactive domain 3C (BRIGHT- like) [Homo s... 83 2e-15
gi|74136549 AT rich interactive domain 5B (MRF1-like) [Homo sapi... 79 4e-14
gi|4885193 AT rich interactive domain 3A (BRIGHT- like) protein ... 75 3e-13
gi|56676335 RAP1 interacting factor 1 [Homo sapiens] 72 3e-12
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 72 4e-12
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 72 4e-12
gi|47078224 AT rich interactive domain 5A [Homo sapiens] 71 6e-12
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 70 1e-11
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 70 2e-11
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 70 2e-11
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 69 4e-11
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 69 4e-11
gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sap... 68 5e-11
gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sap... 68 5e-11
gi|40068464 AT rich interactive domain 1B (SWI1-like) isoform 2 ... 67 8e-11
gi|40068462 AT rich interactive domain 1B (SWI1-like) isoform 3 ... 67 8e-11
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 67 1e-10
gi|71061468 centromere protein E [Homo sapiens] 67 1e-10
gi|87299628 biorientation of chromosomes in cell division 1-like... 65 3e-10
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 65 4e-10
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 65 4e-10
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 65 5e-10
>gi|115334677 retinoblastoma-binding protein 1 isoform I [Homo
sapiens]
Length = 1257
Score = 2488 bits (6448), Expect = 0.0
Identities = 1257/1257 (100%), Positives = 1257/1257 (100%)
Query: 1 MKAADEPAYLTVGTDVSAKYRGAFCEAKIKTVKRLVKVKVLLKQDNTTQLVQDDQVKGPL 60
MKAADEPAYLTVGTDVSAKYRGAFCEAKIKTVKRLVKVKVLLKQDNTTQLVQDDQVKGPL
Sbjct: 1 MKAADEPAYLTVGTDVSAKYRGAFCEAKIKTVKRLVKVKVLLKQDNTTQLVQDDQVKGPL 60
Query: 61 RVGAIVETRTSDGSFQEAIISKLTDASWYTVVFDDGDERTLRRTSLCLKGERHFAESETL 120
RVGAIVETRTSDGSFQEAIISKLTDASWYTVVFDDGDERTLRRTSLCLKGERHFAESETL
Sbjct: 61 RVGAIVETRTSDGSFQEAIISKLTDASWYTVVFDDGDERTLRRTSLCLKGERHFAESETL 120
Query: 121 DQLPLTNPEHFGTPVIAKKTNRGRRSSLPVTEDEKEEESSEEEDEDKRRLNDELLGKVVS 180
DQLPLTNPEHFGTPVIAKKTNRGRRSSLPVTEDEKEEESSEEEDEDKRRLNDELLGKVVS
Sbjct: 121 DQLPLTNPEHFGTPVIAKKTNRGRRSSLPVTEDEKEEESSEEEDEDKRRLNDELLGKVVS 180
Query: 181 VVSATERTEWYPALVISPSCNDDITVKKDQCLVRSFIDSKFYSIARKDIKEVDILNLPES 240
VVSATERTEWYPALVISPSCNDDITVKKDQCLVRSFIDSKFYSIARKDIKEVDILNLPES
Sbjct: 181 VVSATERTEWYPALVISPSCNDDITVKKDQCLVRSFIDSKFYSIARKDIKEVDILNLPES 240
Query: 241 ELSTKPGLQKASIFLKTRVVPDNWKMDISEILESSSSDDEDGPAEENDEEKEKEAKKTEE 300
ELSTKPGLQKASIFLKTRVVPDNWKMDISEILESSSSDDEDGPAEENDEEKEKEAKKTEE
Sbjct: 241 ELSTKPGLQKASIFLKTRVVPDNWKMDISEILESSSSDDEDGPAEENDEEKEKEAKKTEE 300
Query: 301 EVPEEELDPEERDNFLQQLYKFMEDRGTPINKPPVLGYKDLNLFKLFRLVYHQGGCDNID 360
EVPEEELDPEERDNFLQQLYKFMEDRGTPINKPPVLGYKDLNLFKLFRLVYHQGGCDNID
Sbjct: 301 EVPEEELDPEERDNFLQQLYKFMEDRGTPINKPPVLGYKDLNLFKLFRLVYHQGGCDNID 360
Query: 361 SGAVWKQIYMDLGIPILNSAASYNVKTAYRKYLYGFEEYCRSANIQFRTVHHHEPKVKEE 420
SGAVWKQIYMDLGIPILNSAASYNVKTAYRKYLYGFEEYCRSANIQFRTVHHHEPKVKEE
Sbjct: 361 SGAVWKQIYMDLGIPILNSAASYNVKTAYRKYLYGFEEYCRSANIQFRTVHHHEPKVKEE 420
Query: 421 KKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPRGRRRIARDVNSI 480
KKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPRGRRRIARDVNSI
Sbjct: 421 KKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPRGRRRIARDVNSI 480
Query: 481 KKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKKIKKQEDSDK 540
KKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKKIKKQEDSDK
Sbjct: 481 KKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKKIKKQEDSDK 540
Query: 541 DSDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVKYGRGKTQKIYEASIKSTE 600
DSDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVKYGRGKTQKIYEASIKSTE
Sbjct: 541 DSDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVKYGRGKTQKIYEASIKSTE 600
Query: 601 IDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDSEKDEKRDEE 660
IDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDSEKDEKRDEE
Sbjct: 601 IDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDSEKDEKRDEE 660
Query: 661 RQKSKRGRPPLKSTLSSNMPYGLSKTANSEGKSDSCSSDSETEDALEKNLINEELSLKDE 720
RQKSKRGRPPLKSTLSSNMPYGLSKTANSEGKSDSCSSDSETEDALEKNLINEELSLKDE
Sbjct: 661 RQKSKRGRPPLKSTLSSNMPYGLSKTANSEGKSDSCSSDSETEDALEKNLINEELSLKDE 720
Query: 721 LEKNENLNDDKLDEENPKISAHILKENDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTE 780
LEKNENLNDDKLDEENPKISAHILKENDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTE
Sbjct: 721 LEKNENLNDDKLDEENPKISAHILKENDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTE 780
Query: 781 EVKKEAEKSPKGKGRRSKTKDLSLEIIKISSFGQNEAGSEPHIEAHSLELSSLDNKNFSS 840
EVKKEAEKSPKGKGRRSKTKDLSLEIIKISSFGQNEAGSEPHIEAHSLELSSLDNKNFSS
Sbjct: 781 EVKKEAEKSPKGKGRRSKTKDLSLEIIKISSFGQNEAGSEPHIEAHSLELSSLDNKNFSS 840
Query: 841 ATEDEIDQCVKEKKLKRKILGQSSPEKKIRIENGMEMTNTVSQERTSDCIGSEGMKNLNF 900
ATEDEIDQCVKEKKLKRKILGQSSPEKKIRIENGMEMTNTVSQERTSDCIGSEGMKNLNF
Sbjct: 841 ATEDEIDQCVKEKKLKRKILGQSSPEKKIRIENGMEMTNTVSQERTSDCIGSEGMKNLNF 900
Query: 901 EQHFERENEGMPSLIAESNQCIQQLTSERFDSPAEETVNIPLKEDEDAMPLIGPETLVCH 960
EQHFERENEGMPSLIAESNQCIQQLTSERFDSPAEETVNIPLKEDEDAMPLIGPETLVCH
Sbjct: 901 EQHFERENEGMPSLIAESNQCIQQLTSERFDSPAEETVNIPLKEDEDAMPLIGPETLVCH 960
Query: 961 EVDLDDLDEKDKTSIEDVAVESSESNSLVSIPPALPPVVQHNFSVASPLTLSQDESRSVK 1020
EVDLDDLDEKDKTSIEDVAVESSESNSLVSIPPALPPVVQHNFSVASPLTLSQDESRSVK
Sbjct: 961 EVDLDDLDEKDKTSIEDVAVESSESNSLVSIPPALPPVVQHNFSVASPLTLSQDESRSVK 1020
Query: 1021 SESDITIEVDSIAEESQEGLCERESANGFETNVASGTCSIIVQERESREKGQKRPSDGNS 1080
SESDITIEVDSIAEESQEGLCERESANGFETNVASGTCSIIVQERESREKGQKRPSDGNS
Sbjct: 1021 SESDITIEVDSIAEESQEGLCERESANGFETNVASGTCSIIVQERESREKGQKRPSDGNS 1080
Query: 1081 GLMAKKQKRTPKRTSAAAKNEKNGTGQSSDSEDLPVLDNSSKCTPVKHLNVSKPQKLARS 1140
GLMAKKQKRTPKRTSAAAKNEKNGTGQSSDSEDLPVLDNSSKCTPVKHLNVSKPQKLARS
Sbjct: 1081 GLMAKKQKRTPKRTSAAAKNEKNGTGQSSDSEDLPVLDNSSKCTPVKHLNVSKPQKLARS 1140
Query: 1141 PARISPHIKDGEKDKHREKHPNSSPRTYKWSFQLNELDNMNSTERISFLQEKLQEIRKYY 1200
PARISPHIKDGEKDKHREKHPNSSPRTYKWSFQLNELDNMNSTERISFLQEKLQEIRKYY
Sbjct: 1141 PARISPHIKDGEKDKHREKHPNSSPRTYKWSFQLNELDNMNSTERISFLQEKLQEIRKYY 1200
Query: 1201 MSLKSEVATIDRRRKRLKKKDREVSHAGASMSSASSDTGMSPSSSSPPQNVLAVECR 1257
MSLKSEVATIDRRRKRLKKKDREVSHAGASMSSASSDTGMSPSSSSPPQNVLAVECR
Sbjct: 1201 MSLKSEVATIDRRRKRLKKKDREVSHAGASMSSASSDTGMSPSSSSPPQNVLAVECR 1257
>gi|115334673 retinoblastoma-binding protein 1 isoform II [Homo
sapiens]
Length = 1203
Score = 2328 bits (6033), Expect = 0.0
Identities = 1195/1257 (95%), Positives = 1199/1257 (95%), Gaps = 54/1257 (4%)
Query: 1 MKAADEPAYLTVGTDVSAKYRGAFCEAKIKTVKRLVKVKVLLKQDNTTQLVQDDQVKGPL 60
MKAADEPAYLTVGTDVSAKYRGAFCEAKIKTVKRLVKVKVLLKQDNTTQLVQDDQVKGPL
Sbjct: 1 MKAADEPAYLTVGTDVSAKYRGAFCEAKIKTVKRLVKVKVLLKQDNTTQLVQDDQVKGPL 60
Query: 61 RVGAIVETRTSDGSFQEAIISKLTDASWYTVVFDDGDERTLRRTSLCLKGERHFAESETL 120
RVGAIVETRTSDGSFQEAIISKLTDASWYTVVFDDGDERTLRRTSLCLKGERHFAESETL
Sbjct: 61 RVGAIVETRTSDGSFQEAIISKLTDASWYTVVFDDGDERTLRRTSLCLKGERHFAESETL 120
Query: 121 DQLPLTNPEHFGTPVIAKKTNRGRRSSLPVTEDEKEEESSEEEDEDKRRLNDELLGKVVS 180
DQLPLTNPEHFGTPVIAKKTNRGRRSSLPVTEDEKEEESSEEEDEDKRRLNDELLGKVVS
Sbjct: 121 DQLPLTNPEHFGTPVIAKKTNRGRRSSLPVTEDEKEEESSEEEDEDKRRLNDELLGKVVS 180
Query: 181 VVSATERTEWYPALVISPSCNDDITVKKDQCLVRSFIDSKFYSIARKDIKEVDILNLPES 240
VVSATERTEWYPALVISPSCNDDITVKKDQCLVRSFIDSKFYSIARKDIKEVDILNLPES
Sbjct: 181 VVSATERTEWYPALVISPSCNDDITVKKDQCLVRSFIDSKFYSIARKDIKEVDILNLPES 240
Query: 241 ELSTKPGLQKASIFLKTRVVPDNWKMDISEILESSSSDDEDGPAEENDEEKEKEAKKTEE 300
ELSTKPGLQKASIFLKTRVVPDNWKMDISEILESSSSDDEDGPAEENDEEKEKEAKKTEE
Sbjct: 241 ELSTKPGLQKASIFLKTRVVPDNWKMDISEILESSSSDDEDGPAEENDEEKEKEAKKTEE 300
Query: 301 EVPEEELDPEERDNFLQQLYKFMEDRGTPINKPPVLGYKDLNLFKLFRLVYHQGGCDNID 360
EVPEEELDPEERDNFLQQLYKFMEDRGTPINKPPVLGYKDLNLFKLFRLVYHQGGCDNID
Sbjct: 301 EVPEEELDPEERDNFLQQLYKFMEDRGTPINKPPVLGYKDLNLFKLFRLVYHQGGCDNID 360
Query: 361 SGAVWKQIYMDLGIPILNSAASYNVKTAYRKYLYGFEEYCRSANIQFRTVHHHEPKVKEE 420
SGAVWKQIYMDLGIPILNSAASYNVKTAYRKYLYGFEEYCRSANIQFRTVHHHEPKVKEE
Sbjct: 361 SGAVWKQIYMDLGIPILNSAASYNVKTAYRKYLYGFEEYCRSANIQFRTVHHHEPKVKEE 420
Query: 421 KKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPRGRRRIARDVNSI 480
KKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPRGRRRIARDVNSI
Sbjct: 421 KKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPRGRRRIARDVNSI 480
Query: 481 KKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKKIKKQEDSDK 540
KKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKKIKKQEDSDK
Sbjct: 481 KKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKKIKKQEDSDK 540
Query: 541 DSDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVKYGRGKTQKIYEASIKSTE 600
DSDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVKYGRGKTQKIYEASIKSTE
Sbjct: 541 DSDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVKYGRGKTQKIYEASIKSTE 600
Query: 601 IDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDSEKDEKRDEE 660
IDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDSEKDEKRDEE
Sbjct: 601 IDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDSEKDEKRDEE 660
Query: 661 RQKSKRGRPPLKSTLSSNMPYGLSKTANSEGKSDSCSSDSETEDALEKNLINEELSLKDE 720
RQKSKRGRPPLKSTLSSNMPYGLSKTANSEGKSDSCSSDSETEDALEKNLINEELSLKDE
Sbjct: 661 RQKSKRGRPPLKSTLSSNMPYGLSKTANSEGKSDSCSSDSETEDALEKNLINEELSLKDE 720
Query: 721 LEKNENLNDDKLDEENPKISAHILKENDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTE 780
LEKNENLNDDKLDEENPKISAHILKENDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTE
Sbjct: 721 LEKNENLNDDKLDEENPKISAHILKENDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTE 780
Query: 781 EVKKEAEKSPKGKGRRSKTKDLSLEIIKISSFGQNEAGSEPHIEAHSLELSSLDNKNFSS 840
EVKKEAEKSPKGKGRRSKTKDLSLEIIKISSFGQNEAGSEPHIEAHSLELSSLDNKNFSS
Sbjct: 781 EVKKEAEKSPKGKGRRSKTKDLSLEIIKISSFGQNEAGSEPHIEAHSLELSSLDNKNFSS 840
Query: 841 ATEDEIDQCVKEKKLKRKILGQSSPEKKIRIENGMEMTNTVSQERTSDCIGSEGMKNLNF 900
ATEDEIDQCVKEKKLKRKILGQSSPEKKIRIENGMEMTNTVSQERTSDCIGSEGMKNLNF
Sbjct: 841 ATEDEIDQCVKEKKLKRKILGQSSPEKKIRIENGMEMTNTVSQERTSDCIGSEGMKNLNF 900
Query: 901 EQHFERENEGMPSLIAESNQCIQQLTSERFDSPAEETVNIPLKEDEDAMPLIGPETLVCH 960
EQHFERENEGMPSLIAESNQCIQQLTSERFDSPAEETVNIPLKEDEDAMPLIGPETLVCH
Sbjct: 901 EQHFERENEGMPSLIAESNQCIQQLTSERFDSPAEETVNIPLKEDEDAMPLIGPETLVCH 960
Query: 961 EVDLDDLDEKDKTSIEDVAVESSESNSLVSIPPALPPVVQHNFSVASPLTLSQDESRSVK 1020
EVDLDDLDEKDKTSIEDVAVESSESNSLVSIPPALPPVVQHNFSVASPLTLSQDESRSVK
Sbjct: 961 EVDLDDLDEKDKTSIEDVAVESSESNSLVSIPPALPPVVQHNFSVASPLTLSQDESRSVK 1020
Query: 1021 SESDITIEVDSIAEESQEGLCERESANGFETNVASGTCSIIVQERESREKGQKRPSDGNS 1080
SESDITIEVDSIAEESQEGLCERESANGFETNVASGTCSIIVQERESREKGQKRPSDGNS
Sbjct: 1021 SESDITIEVDSIAEESQEGLCERESANGFETNVASGTCSIIVQERESREKGQKRPSDGNS 1080
Query: 1081 GLMAKKQKRTPKRTSAAAKNEKNGTGQSSDSEDLPVLDNSSKCTPVKHLNVSKPQKLARS 1140
GLMAKKQKRTPKRTSAAAKNEKNGTGQSSDSEDLPVLDNS++
Sbjct: 1081 GLMAKKQKRTPKRTSAAAKNEKNGTGQSSDSEDLPVLDNSNEL----------------- 1123
Query: 1141 PARISPHIKDGEKDKHREKHPNSSPRTYKWSFQLNELDNMNSTERISFLQEKLQEIRKYY 1200
+ NS+ R ISFLQEKLQEIRKYY
Sbjct: 1124 ------------------DNMNSTER-------------------ISFLQEKLQEIRKYY 1146
Query: 1201 MSLKSEVATIDRRRKRLKKKDREVSHAGASMSSASSDTGMSPSSSSPPQNVLAVECR 1257
MSLKSEVATIDRRRKRLKKKDREVSHAGASMSSASSDTGMSPSSSSPPQNVLAVECR
Sbjct: 1147 MSLKSEVATIDRRRKRLKKKDREVSHAGASMSSASSDTGMSPSSSSPPQNVLAVECR 1203
>gi|115334679 retinoblastoma-binding protein 1 isoform III [Homo
sapiens]
Length = 1188
Score = 2189 bits (5673), Expect = 0.0
Identities = 1135/1257 (90%), Positives = 1151/1257 (91%), Gaps = 69/1257 (5%)
Query: 1 MKAADEPAYLTVGTDVSAKYRGAFCEAKIKTVKRLVKVKVLLKQDNTTQLVQDDQVKGPL 60
MKAADEPAYLTVGTDVSAKYRGAFCEAKIKTVKRLVKVKVLLKQDNTTQLVQDDQVKGPL
Sbjct: 1 MKAADEPAYLTVGTDVSAKYRGAFCEAKIKTVKRLVKVKVLLKQDNTTQLVQDDQVKGPL 60
Query: 61 RVGAIVETRTSDGSFQEAIISKLTDASWYTVVFDDGDERTLRRTSLCLKGERHFAESETL 120
RVGAIVETRTSDGSFQEAIISKLTDASWYTVVFDDGDERTLRRTSLCLKGERHFAESETL
Sbjct: 61 RVGAIVETRTSDGSFQEAIISKLTDASWYTVVFDDGDERTLRRTSLCLKGERHFAESETL 120
Query: 121 DQLPLTNPEHFGTPVIAKKTNRGRRSSLPVTEDEKEEESSEEEDEDKRRLNDELLGKVVS 180
DQLPLTNPEHFGTPVIAKKTNRGRRSSLPVTEDEKEEESSEEEDEDKRRLNDELLGKVVS
Sbjct: 121 DQLPLTNPEHFGTPVIAKKTNRGRRSSLPVTEDEKEEESSEEEDEDKRRLNDELLGKVVS 180
Query: 181 VVSATERTEWYPALVISPSCNDDITVKKDQCLVRSFIDSKFYSIARKDIKEVDILNLPES 240
VVSATERTEWYPALVISPSCNDDITVKKDQCLVRSFIDSKFYSIARKDIKEVDILNLPES
Sbjct: 181 VVSATERTEWYPALVISPSCNDDITVKKDQCLVRSFIDSKFYSIARKDIKEVDILNLPES 240
Query: 241 ELSTKPGLQKASIFLKTRVVPDNWKMDISEILESSSSDDEDGPAEENDEEKEKEAKKTEE 300
ELSTKPGLQKASIFLKTRVVPDNWKMDISEILESSSSDDEDGPAEENDEEKEKEAKKTEE
Sbjct: 241 ELSTKPGLQKASIFLKTRVVPDNWKMDISEILESSSSDDEDGPAEENDEEKEKEAKKTEE 300
Query: 301 EVPEEELDPEERDNFLQQLYKFMEDRGTPINKPPVLGYKDLNLFKLFRLVYHQGGCDNID 360
EVPEEELDPEERDNFLQQLYKFMEDRGTPINKPPVLGYKDLNLFKLFRLVYHQGGCDNID
Sbjct: 301 EVPEEELDPEERDNFLQQLYKFMEDRGTPINKPPVLGYKDLNLFKLFRLVYHQGGCDNID 360
Query: 361 SGAVWKQIYMDLGIPILNSAASYNVKTAYRKYLYGFEEYCRSANIQFRTVHHHEPKVKEE 420
SGAVWKQIYMDLGIPILNSAASYNVKTAYRKYLYGFEEYCRSANIQFRTVHHHEPKVKEE
Sbjct: 361 SGAVWKQIYMDLGIPILNSAASYNVKTAYRKYLYGFEEYCRSANIQFRTVHHHEPKVKEE 420
Query: 421 KKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPRGRRRIARDVNSI 480
KKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPRGRRRIARDVNSI
Sbjct: 421 KKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPRGRRRIARDVNSI 480
Query: 481 KKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKKIKKQEDSDK 540
KKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKKIKKQEDSDK
Sbjct: 481 KKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKKIKKQEDSDK 540
Query: 541 DSDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVKYGRGKTQKIYEASIKSTE 600
DSDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVKYGRGKTQKIYEASIKSTE
Sbjct: 541 DSDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVKYGRGKTQKIYEASIKSTE 600
Query: 601 IDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDSEKDEKRDEE 660
IDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDSEKDEKRDEE
Sbjct: 601 IDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDSEKDEKRDEE 660
Query: 661 RQKSKRGRPPLKSTLSSNMPYGLSKTANSEGKSDSCSSDSETEDALEKNLINEELSLKDE 720
RQKSKRGRPPLKSTLSSNMPYGLSKTANSEGKSDSCSSDSETEDALEKNLINEELSLKDE
Sbjct: 661 RQKSKRGRPPLKSTLSSNMPYGLSKTANSEGKSDSCSSDSETEDALEKNLINEELSLKDE 720
Query: 721 LEKNENLNDDKLDEENPKISAHILKENDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTE 780
LEKNENLNDDKLDEENPKISAHILKENDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTE
Sbjct: 721 LEKNENLNDDKLDEENPKISAHILKENDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTE 780
Query: 781 EVKKEAEKSPKGKGRRSKTKDLSLEIIKISSFGQNEAGSEPHIEAHSLELSSLDNKNFSS 840
EVKKEAEKSPKGKGRRSKTKDLSLEIIKISSFGQNEAGSEPHIEAHSLELSSLDNKNFSS
Sbjct: 781 EVKKEAEKSPKGKGRRSKTKDLSLEIIKISSFGQNEAGSEPHIEAHSLELSSLDNKNFSS 840
Query: 841 ATEDEIDQCVKEKKLKRKILGQSSPEKKIRIENGMEMTNTVSQERTSDCIGSEGMKNLNF 900
ATEDEIDQCVKEKKLKRKILGQSSPEKKIRIENGMEMTNTVSQERTSDCIGSEGMKNLNF
Sbjct: 841 ATEDEIDQCVKEKKLKRKILGQSSPEKKIRIENGMEMTNTVSQERTSDCIGSEGMKNLNF 900
Query: 901 EQHFERENEGMPSLIAESNQCIQQLTSERFDSPAEETVNIPLKEDEDAMPLIGPETLVCH 960
EQHFERENEGMPSLIAESNQCIQQLTSERFDSPAEETVNIPLKEDEDAMPLIGPETLVCH
Sbjct: 901 EQHFERENEGMPSLIAESNQCIQQLTSERFDSPAEETVNIPLKEDEDAMPLIGPETLVCH 960
Query: 961 EVDLDDLDEKDKTSIEDVAVESSESNSLVSIPPALPPVVQHNFSVASPLTLSQDESRSVK 1020
EVDLDDLDEKDKTSIEDVAVESSESNSLVSIPPALPPVVQHNFSVASPLTLSQDESRSVK
Sbjct: 961 EVDLDDLDEKDKTSIEDVAVESSESNSLVSIPPALPPVVQHNFSVASPLTLSQDESRSVK 1020
Query: 1021 SESDITIEVDSIAEESQEGLCERESANGFETNVASGTCSIIVQERESREKGQKRPSDGNS 1080
SESDITIEVDSIAEESQEGLCERESANGFETNVASGTCSIIVQERESREKGQKRPSDGNS
Sbjct: 1021 SESDITIEVDSIAEESQEGLCERESANGFETNVASGTCSIIVQERESREKGQKRPSDGNS 1080
Query: 1081 GLMAKKQKRTPKRTSAAAKNEKNGTGQSSDSEDLPVLDNSSKCTPVKHLNVSKPQKLARS 1140
GLMAKKQKRTPKRTSAAAKNEKNGT + LDN + + L K Q++ +
Sbjct: 1081 GLMAKKQKRTPKRTSAAAKNEKNGTDE---------LDNMNSTERISFLQ-EKLQEIRKY 1130
Query: 1141 PARISPHIKDGEKDKHREKHPNSSPRTYKWSFQLNELDNMNSTERISFLQEKLQEIRKYY 1200
+ + ++ + R L++K +E+
Sbjct: 1131 YMSLKSEVATIDRRRKR-------------------------------LKKKDREVSHAG 1159
Query: 1201 MSLKSEVATIDRRRKRLKKKDREVSHAGASMSSASSDTGMSPSSSSPPQNVLAVECR 1257
S+ S S G S SS SSPPQNVLAVECR
Sbjct: 1160 ASMSS-----------------ASSDTGMSPSS-----------SSPPQNVLAVECR 1188
>gi|22035677 AT rich interactive domain 4B isoform 1 [Homo sapiens]
Length = 1312
Score = 925 bits (2391), Expect = 0.0
Identities = 597/1346 (44%), Positives = 798/1346 (59%), Gaps = 123/1346 (9%)
Query: 1 MKAADEPAYLTVGTDVSAKYRGAFCEAKIKTVKRLVKVKVLLKQDNTTQLVQDDQVKGPL 60
MKA DEP YLTVGTDVSAKYRGAFCEAKIKT KRLVKVKV + D++T VQDD +KGPL
Sbjct: 1 MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPL 60
Query: 61 RVGAIVETRTSDGSFQEAIISKLTDASWYTVVFDDGDERTLRRTSLCLKGERHFAESETL 120
+VGAIVE + DG++QEA+I+KLTDASWYTVVFDDGDE+TLRR+SLCLKGERHFAESETL
Sbjct: 61 KVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETL 120
Query: 121 DQLPLTNPEHFGTPVIAKKTNRGRRSS-LPVTEDEKEEESSEEEDEDKRRLNDELLGKVV 179
DQLPLTNPEHFGTPVI KKTNRGRRS+ +P +E+ SS +EDED R+ DELLGKVV
Sbjct: 121 DQLPLTNPEHFGTPVIGKKTNRGRRSNHIP---EEESSSSSSDEDEDDRKQIDELLGKVV 177
Query: 180 SVVSAT---ERTEWYPALVISPSCNDDITVKKDQCLVRSFIDSKFYSIARKDIKEVDILN 236
V + ++ W+PALV+ P C+D+I VKKD LVRSF D KF S+ RKD+ E+
Sbjct: 178 CVDYISLDKKKALWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDT 237
Query: 237 LPESELSTKPGLQKASIFLKTRVVPDNWKMDISEILESSSSDDEDGPAEENDEEKEKEAK 296
P+ + K ++A F K+R +P NWK ++ E SS +++E+ EE D+EKEKE
Sbjct: 238 APKPDAVLKQAFEQALEFHKSRTIPANWKTELKEDSSSSEAEEEE---EEEDDEKEKEDN 294
Query: 297 KTEEEVPEEELDPEERDNFLQQLYKFMEDRGTPINKPPVLGYKDLNLFKLFRLVYHQGGC 356
+EEE E E PEER+NFLQQLYKFMEDRGTPINK PVLGY++LNLFKLFRLV+ GG
Sbjct: 295 SSEEE-EEIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGF 353
Query: 357 DNIDSGAVWKQIYMDLGIPILNSAASYNVKTAYRKYLYGFEEYCRSANIQFRTVHHHEPK 416
DNI+SGAVWKQ+Y DLGIP+LNSAA YNVK AY+KYLYGFEEYCRSANI+F+ + E
Sbjct: 354 DNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQ-MALPEKV 412
Query: 417 VKEEKKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESE-REEIE----LKSPRGRR 471
V ++ K+ E E +K + E + E+K E E NI E +EIE +K G +
Sbjct: 413 VNKQCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSK 472
Query: 472 RIARDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKK 531
+ + SI ++EK + K D EN D DD T + + + + + +
Sbjct: 473 K--NLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGDE 530
Query: 532 IKKQEDSDKDSDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVKYGRGKTQKI 591
K+ED D + EEEE+ +E EE E D + +EE+ E G KV+V+YGRGK QK+
Sbjct: 531 TNKEEDEDDEEAEEEEEEEEEEEDE---DDDDNNEEEEFECYPPGMKVQVRYGRGKNQKM 587
Query: 592 YEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDS 651
YEASIK ++++ GEVLYLVHY GWNVRYDEW+KAD+I+ P DK PK K +KK KNK D
Sbjct: 588 YEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDK 647
Query: 652 E--KDEKRDEERQKSKR-GRPPLKSTLSSNMPYGLSKT------------------ANSE 690
E KDEK + K +R +PP ++ S M L T N
Sbjct: 648 EKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGL 707
Query: 691 GKSDSCSSDSETED----------ALEKNLINEELSLKDELEKNENLNDDKLDEENP--- 737
S+S + DSE ED E++ I+ + +++L E N L EEN
Sbjct: 708 QASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHA 767
Query: 738 --KISAHILKENDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTEEVKKE-AEKSPKGKG 794
IS + K +R + + +E L + E V +K ++VKK+ +KS K +
Sbjct: 768 DLVISKPVSKSPERLR-KDIEVLSEDTDYEEDEV------TKKRKDVKKDTTDKSSKPQI 820
Query: 795 RRSKTKDLSL-EIIKISSFGQNEAGSEPHIEAHSLELSSLDNKNFSSATEDEIDQCVKEK 853
+R K + + E +K S G+ E +A + E ++N + SS+ EDE + K
Sbjct: 821 KRGKRRYCNTEECLKTGSPGKKEE------KAKNKESLCMENSSNSSSDEDEEETKAKMT 874
Query: 854 KLKRKILGQSSPEKKIRIENGMEMTNTVSQERTSDCIGSEGMKNLNFEQHFERENEGMPS 913
K K G K +R + V+++R S+ + L + +R++
Sbjct: 875 PTK-KYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSD--ERLQNSRAKDRKDVWSSI 931
Query: 914 LIAESNQCIQQLTSERFDSPAEETVNIPLKED---EDAMPLIGPETLVCHEVDLDDLD-- 968
+ +++L S+ D+ A + P E+ E+++ + E V+L+
Sbjct: 932 QGQWPKKTLKELFSDS-DTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPV 990
Query: 969 EKDKTSIEDVAVE---------SSESNSLVSIPPALPPV-----------VQHNFSVASP 1008
D IE+ VE SS SNS+++ PP P Q + +V+ P
Sbjct: 991 NVDSKPIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEP 1050
Query: 1009 LTLSQDESRSVKSESDITIEVDSIAEESQEGLCE-RESANGFETNVASGTCSIIVQERES 1067
L +Q+E RS+KSE+D TIEVDS+A E Q+ E S GF+ +V+S + + E E
Sbjct: 1051 LAPNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSN--QPEPEH 1108
Query: 1068 REK---GQKRPSDG-NSGLMAKKQKRTPKRTSAAAKNEKNGTG-QSSDSEDLPVLDNSSK 1122
EK GQKR D G +KKQKR+ K T N+K G G SSDSE+L ++ +K
Sbjct: 1109 PEKACTGQKRVKDAQGGGSSSKKQKRSHKAT--VVNNKKKGKGTNSSDSEELSAGESITK 1166
Query: 1123 CTPVKHLNVSKPQKLARSPARI-SPHI--KDGEKDKHREKHPNSSPRTYKWSFQLNELDN 1179
PVK ++ +SPAR SP K+G+KD ++ N P+ YKWSFQ+++L+N
Sbjct: 1167 SQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDKDPDLKEPSNRLPKVYKWSFQMSDLEN 1226
Query: 1180 MNSTERISFLQEKLQEIRKYYMSLKSEVATIDRRRKRLKKKDREVSHAGASMSSASSD-- 1237
M S ERI+ LQEKLQEIRK+Y+SLKSEVA+IDRRRKRLKKK+RE + +S SS SS
Sbjct: 1227 MTSAERITILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSSSSSPSSSSI 1286
Query: 1238 ------TGMSPSSSSPPQNVLAVECR 1257
T PS SS QN ++VECR
Sbjct: 1287 TAAVMLTLAEPSMSSASQNGMSVECR 1312
>gi|22035679 AT rich interactive domain 4B isoform 2 [Homo sapiens]
Length = 1226
Score = 773 bits (1997), Expect = 0.0
Identities = 531/1313 (40%), Positives = 739/1313 (56%), Gaps = 143/1313 (10%)
Query: 1 MKAADEPAYLTVGTDVSAKYRGAFCEAKIKTVKRLVKVKVLLKQDNTTQLVQDDQVKGPL 60
MKA DEP YLTVGTDVSAKYRGAFCEAKIKT KRLVKVKV + D++T VQDD +KGPL
Sbjct: 1 MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPL 60
Query: 61 RVGAIVETRTSDGSFQEAIISKLTDASWYTVVFDDGDERTLRRTSLCLKGERHFAESETL 120
+VGAIVE + DG++QEA+I+KLTDASWYTVVFDDGDE+TLRR+SLCLKGERHFAESETL
Sbjct: 61 KVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETL 120
Query: 121 DQLPLTNPEHFGTPVIAKKTNRGRRSS-LPVTEDEKEEESSEEEDEDKRRLNDELLGKVV 179
DQLPLTNPEHFGTPVI KKTNRGRRS+ +P +E+ SS +EDED R+ DELLGKVV
Sbjct: 121 DQLPLTNPEHFGTPVIGKKTNRGRRSNHIP---EEESSSSSSDEDEDDRKQIDELLGKVV 177
Query: 180 SVVSAT---ERTEWYPALVISPSCNDDITVKKDQCLVRSFIDSKFYSIARKDIKEVDILN 236
V + ++ W+PALV+ P C+D+I VKKD LVRSF D KF S+ RKD+ E+
Sbjct: 178 CVDYISLDKKKALWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDT 237
Query: 237 LPESELSTKPGLQKASIFLKTRVVPDNWKMDISEILESSSSDDEDGPAEENDEEKEKEAK 296
P+ + K ++A F K+R +P NWK ++ E SS +++E+ EE D+EKEKE
Sbjct: 238 APKPDAVLKQAFEQALEFHKSRTIPANWKTELKEDSSSSEAEEEE---EEEDDEKEKEDN 294
Query: 297 KTEEEVPEEELDPEERDNFLQQLYKFMEDRGTPINKPPVLGYKDLNLFKLFRLVYHQGGC 356
+EEE E E PEER+NFLQQLYKFMEDRGTPINK PVLGY++LNLFKLFRLV+ GG
Sbjct: 295 SSEEE-EEIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGF 353
Query: 357 DNIDSGAVWKQIYMDLGIPILNSAASYNVKTAYRKYLYGFEEYCRSANIQFRTVHHHEPK 416
DNI+SGAVWKQ+Y DLGIP+LNSAA YNVK AY+KYLYGFEEYCRSANI+F+ + E
Sbjct: 354 DNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQ-MALPEKV 412
Query: 417 VKEEKKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESE-REEIE----LKSPRGRR 471
V ++ K+ E E +K + E + E+K E E NI E +EIE +K G +
Sbjct: 413 VNKQCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSK 472
Query: 472 RIARDVNSIKKEIEEEKTEDKLKDNDTEN-KDVDDDYETAEKKENELLLGRKNTPKQKEK 530
+ + SI ++EK + K D EN D DDD ++ N + + K
Sbjct: 473 K--NLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGYD 530
Query: 531 KIKKQEDSDKDSDEEEEKSQEREETESKCDSEGEEDEE-DMEPCLTGTKVKVKYGRGKTQ 589
+ K + + +D+ K + R++ ++K D E ++DE+ + C K + +
Sbjct: 531 EWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSP 590
Query: 590 KIYEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKE 649
++ + ++ D + H +K+ I L+ + + E
Sbjct: 591 EM----VSKLDLTDAKNSDTAH-----------IKSIEITSILN------GLQASESSAE 629
Query: 650 DSEKDEKRDEERQKSKRGRPPLKSTLSSNMPYGLSKTANSEGKSDSCSSDSETEDALEKN 709
DSE++++R + + L++N +SK + + LE+N
Sbjct: 630 DSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISK------------EEQNSSSLLEEN 677
Query: 710 LINEELSLKDELEKN-ENLNDDKLDEENPKISAHILKENDRTQMQPLETLKLEVGENEQI 768
++ +L + + K+ E L D +E L + E
Sbjct: 678 KVHADLVISKPVSKSPERLRKD------------------------IEVLSEDTDYEEDE 713
Query: 769 VQIFGNKMEKTEEVKKE-AEKSPKGKGRRSKTKDLSL-EIIKISSFGQNEAGSEPHIEAH 826
V +K ++VKK+ +KS K + +R K + + E +K S G+ E +A
Sbjct: 714 V------TKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEE------KAK 761
Query: 827 SLELSSLDNKNFSSATEDEIDQCVKEKKLKRKILGQSSPEKKIRIENGMEMTNTVSQERT 886
+ E ++N + SS+ EDE + K K K G K +R + V+++R
Sbjct: 762 NKESLCMENSSNSSSDEDEEETKAKMTPTK-KYNGLEEKRKSLRTTGFYSGFSEVAEKRI 820
Query: 887 SDCIGSEGMKNLNFEQHFERENEGMPSLIAESNQCIQQLTSERFDSPAEETVNIPLKED- 945
S+ + L + +R++ + +++L S+ D+ A + P E+
Sbjct: 821 KLLNNSD--ERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDS-DTEAAASPPHPAPEEG 877
Query: 946 --EDAMPLIGPETLVCHEVDLDDLD--EKDKTSIEDVAVE---------SSESNSLVSIP 992
E+++ + E V+L+ D IE+ VE SS SNS+++ P
Sbjct: 878 VAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVLNTP 937
Query: 993 PALPPV-----------VQHNFSVASPLTLSQDESRSVKSESDITIEVDSIAEESQEGLC 1041
P P Q + +V+ PL +Q+E RS+KSE+D TIEVDS+A E Q+
Sbjct: 938 PTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQDLQS 997
Query: 1042 E-RESANGFETNVASGTCSIIVQERESREK---GQKRPSDG-NSGLMAKKQKRTPKRTSA 1096
E S GF+ +V+S + + E E EK GQKR D G +KKQKR+ K T
Sbjct: 998 EGNSSPAGFDASVSSSSSN--QPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRSHKAT-- 1053
Query: 1097 AAKNEKNGTG-QSSDSEDLPVLDNSSKCTPVKHLNVSKPQKLARSPARI-SPHI--KDGE 1152
N+K G G SSDSE+L ++ +K PVK ++ +SPAR SP K+G+
Sbjct: 1054 VVNNKKKGKGTNSSDSEELSAGESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGD 1113
Query: 1153 KDKHREKHPNSSPRTYKWSFQLNELDNMNSTERISFLQEKLQEIRKYYMSLKSEVATIDR 1212
KD ++ N P+ YKWSFQ+++L+NM S ERI+ LQEKLQEIRK+Y+SLKSEVA+IDR
Sbjct: 1114 KDPDLKEPSNRLPKVYKWSFQMSDLENMTSAERITILQEKLQEIRKHYLSLKSEVASIDR 1173
Query: 1213 RRKRLKKKDREVSHAGASMSSASSD--------TGMSPSSSSPPQNVLAVECR 1257
RRKRLKKK+RE + +S SS SS T PS SS QN ++VECR
Sbjct: 1174 RRKRLKKKERESAATSSSSSSPSSSSITAAVMLTLAEPSMSSASQNGMSVECR 1226
>gi|5453638 AT rich interactive domain 3B [Homo sapiens]
Length = 560
Score = 85.1 bits (209), Expect = 4e-16
Identities = 61/198 (30%), Positives = 101/198 (51%), Gaps = 32/198 (16%)
Query: 219 SKFYSIARKDIKEVDILNLPESELSTKPGL---------------QKASIFLKTRVVPDN 263
SK++ + + + D P S L PGL KAS + T P N
Sbjct: 119 SKYFHVQK--VARQDPRVAPMSNLLPAPGLPPHGQQAKEDHTKDASKASPSVSTAGQP-N 175
Query: 264 WKMDISEILESSS----SDDEDGPAEENDEEKEKEAKKTEEEVPEEELDPEERDNFLQQL 319
W +D E L+ + SDD DG + +E + ++ E + DPE ++ FL L
Sbjct: 176 WNLD--EQLKQNGGLAWSDDADGG-------RGREISRDFAKLYELDGDPERKE-FLDDL 225
Query: 320 YKFMEDRGTPINKPPVLGYKDLNLFKLFRLVYHQGGCDNIDSGAVWKQIYMDLGIPILNS 379
+ FM+ RGTPIN+ P++ + L+L+ L++LV +GG I + +W++I L +P +
Sbjct: 226 FVFMQKRGTPINRIPIMAKQILDLYMLYKLVTEKGGLVEIINKKIWREITKGLNLPTSIT 285
Query: 380 AASYNVKTAYRKYLYGFE 397
+A++ ++T Y KYLY +E
Sbjct: 286 SAAFTLRTQYMKYLYAYE 303
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 84.3 bits (207), Expect = 6e-16
Identities = 136/685 (19%), Positives = 257/685 (37%), Gaps = 141/685 (20%)
Query: 409 TVHHHEPKVKEEKKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPR 468
T H K + K++ ++ +E+ K +E + ++K E ENI ++ +SE + + +
Sbjct: 713 TKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEE-RENIPTDKDSEFTSLGMSAIE 771
Query: 469 GRRRIARDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQK 528
+ ++ ++KEI+ EK E +K++ K
Sbjct: 772 E----SIGLHLVEKEIDIEKQEKHIKES-------------------------------K 796
Query: 529 EKKIKKQEDSDKDSDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVKYGRGKT 588
EK K+ + +KD ++ E K+ E+E+ + K + + E+D+ D+ C+ K K K T
Sbjct: 797 EKPEKRSQIKEKDIEKMERKTFEKEK-KIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHT 855
Query: 589 QKIYEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNK 648
+K ++ KS + K ++K ++K K
Sbjct: 856 EKCHKEGEKSKNTA----------------------------AIKKTDDREKSREKMDRK 887
Query: 649 EDSEKDEKRDEERQKSKRGRPPLKSTLSSNMPYGLSKTANSEGKSDSCSSDSETEDALEK 708
D EK EK + ++ K+ S N Y S+ ++ K ++ D
Sbjct: 888 HDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESI 947
Query: 709 NLINEELSLKDELEKNENLNDDKLDEENPKISAHILKENDRTQMQPLET----------- 757
N+ N + +++E +K+ ++ +K E P L ++T+ +PL+T
Sbjct: 948 NITNSK-HIQEE-KKSSIVDGNKAQHEKP------LSLKEKTKDEPLKTPDGKEKDKKDK 999
Query: 758 ---LKLEVGENEQIVQIFGNKMEKTEEVKKEAEKSPKGKGRRSKTKDLSLEIIKISSFGQ 814
E +++ +QI K+E K + + SP K R K K L + + +SF
Sbjct: 1000 DIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSF-- 1057
Query: 815 NEAGSEPHIEAHSLELSSLDNKNFSSATEDEIDQ-----CVKEK---KLKRKILGQSSPE 866
E + LE+ K+ + E ++ C++ K K K K S
Sbjct: 1058 -----ERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKN 1112
Query: 867 KKIRIENGMEMTNTVSQERTSD----------------CIGSEGMKNLNFEQHFERENEG 910
K++ E+T+ ++E+ +G + N R
Sbjct: 1113 KELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENE 1172
Query: 911 MPSLIAESNQCIQQLTSERFDSPAEETVNIPLKEDEDAMPLIGPETLVCHEVDLDDLDEK 970
P L + S I +SE T P++ D D M L E +
Sbjct: 1173 KPGLSSRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFM-------LESSESQMSFSQSP 1225
Query: 971 DKTSIEDVAVESSESNSLVSIPPALPPVVQHNFSVASPLTLSQDESRSVKSESDITIEV- 1029
+ + A+ E +SL +P + P + S + + S ++ + + SE TIEV
Sbjct: 1226 FLSIAKSPALHERELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLIISEGRPTIEVR 1285
Query: 1030 ---------------DSIAEESQEG 1039
+I+EES +G
Sbjct: 1286 RCSMPSVICEHTKQFQTISEESNQG 1310
Score = 60.1 bits (144), Expect = 1e-08
Identities = 180/913 (19%), Positives = 349/913 (38%), Gaps = 181/913 (19%)
Query: 419 EEKKDLEESMEEALKLDQEMPLT----------EVKSEPEENIDSNSESEREEIELKSPR 468
E D+ E+ E L L +E+PL+ E +S ++D N +SE E+ L
Sbjct: 262 ERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICE- 320
Query: 469 GRRRIARDVNSIKKEIEEEKTEDKLKDNDTE--NKDVDDDY--ETAEKKENELLLGRKNT 524
++ + K + E + KD+D E NK +DD + ++KENE + +
Sbjct: 321 -----SKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHL 375
Query: 525 PKQKEK-------KIKKQEDSD---KDSDEEEEKSQEREETESKCDSEGEEDEEDMEPCL 574
++EK K KKQ+ S ++ +E++ + ++ + C E DM+
Sbjct: 376 FAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQ--- 432
Query: 575 TGTKVKVKYGRGKTQKIYEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDK 634
T+K Y S GE
Sbjct: 433 -------------TKKEYVVS--------GE----------------------------- 442
Query: 635 GGPKKKQKKKAKNKEDSEKDEKRDEERQKSKRGRPPLKST-LSSNMPYGLSKTANSEG-- 691
KQK K K K ++ K ++E ++ K G+ + T L+ N S+ EG
Sbjct: 443 ----HKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNF 498
Query: 692 ------KSD----------------SCSSDSETEDALEKNLI-------NEELSLKDELE 722
K D SC + L++ + E+SL+ +L
Sbjct: 499 RKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLV 558
Query: 723 KNENLNDDKLDEENPKISAHILKENDRTQMQPLETLKLEVGE-------NEQIVQIFGN- 774
+ +N + L E + S K ++++ Q + LE GE +E F N
Sbjct: 559 RYDNTESEFLPESS---SVKSCKHKEKSKHQ--KDFHLEFGEKSNAKIKDEDHSPTFENS 613
Query: 775 -----------------KMEKTEEVKKEAEKSPKGKGRRSKTKDLSLEIIKISSFGQNEA 817
K++ E K++ +K +G+ + KTKD + E+ + F E
Sbjct: 614 DCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEF-DREF 672
Query: 818 GSEPHIEAHSLE--LSSLDNKNFSSATEDEIDQCVK-EKKLKRKILGQSSPEKKIRIENG 874
E ++ E ++++++ + + ++++ +K +K K K + + K+ R +
Sbjct: 673 WKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIK 732
Query: 875 MEMTNTVSQERTSDCIGSEGMKNLNFEQHFERENEGMPSLIAES---NQCIQQLTSERFD 931
E + +E+ D E +N+ ++ E + GM S I ES + +++ E+ +
Sbjct: 733 KESEKSFREEKIKDL--KEERENIPTDKDSEFTSLGM-SAIEESIGLHLVEKEIDIEKQE 789
Query: 932 SPAEETVNIPLK----EDEDAMPLIGPETLVCHEVDLDDLDEKDKTSIEDVAVESSESNS 987
+E+ P K +++D + ++ + EKDK + + + E +
Sbjct: 790 KHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDK 849
Query: 988 LVS--IPPALPPVVQHNFSVASPLTLSQDESRSV---KSESDITIEVDSIAEESQEGLCE 1042
L S + + A T +++SR K + + + +AE ++ L E
Sbjct: 850 LYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLME 909
Query: 1043 ---RESANGFETNVASGTCSIIVQERESREKGQKRPSDG--NSGLMAKKQKRTPKRTSAA 1097
++S N + G +E + +EK + + S NS + +++K + + A
Sbjct: 910 KKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKA 969
Query: 1098 AKNEKNGTGQSSDSEDLPVLDNSSKCTPVKHLNVSKPQKLARSPARISPHIK-DGEKDKH 1156
+ + + E L D K K ++ K + + +I+ +K E DK
Sbjct: 970 QHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKP 1029
Query: 1157 REKHPNSSPRTYKWSFQLNELDNMNSTERISFLQEKLQEIRKYYMSLKSEVATIDRRRKR 1216
+ K +S T +L D++ T L K EI +++ K ++ ++ R R
Sbjct: 1030 KPKSSPASKDTRPKEKRLVN-DDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLR 1088
Query: 1217 ------LKKKDRE 1223
LK KD+E
Sbjct: 1089 NRNCLELKIKDKE 1101
Score = 49.7 bits (117), Expect = 2e-05
Identities = 157/820 (19%), Positives = 285/820 (34%), Gaps = 151/820 (18%)
Query: 418 KEEKKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPRGRRRIARDV 477
K E+ D+ + M+E + +++P T S EE RD
Sbjct: 42 KIERSDVSKEMKEKSSMKRKLPFTISPSRNEE-------------------------RDS 76
Query: 478 NSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLL----------GRKNTPKQ 527
++ K+ E++KT+ + + + + Y +E+K+ LL+ N P Q
Sbjct: 77 DTEKEGPEKKKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQ 136
Query: 528 KEKKIKKQEDSDKDSDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVK----- 582
KK S ++ K ER ET + + ++ E G V VK
Sbjct: 137 TTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGW 196
Query: 583 -----------YGRGKTQKIYEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWP 631
Y K A + + +DD L+ G D +
Sbjct: 197 TPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSG---------HRDIVKLL 247
Query: 632 LDKGGPKKKQKKKAKNKEDSEKDEKRDEERQKSKRGRPPLKSTLSSNMPYGLSKTANSEG 691
L GG + K + D + EE + + PL S +++ N
Sbjct: 248 LRHGGNPFQANKHGERPVDVAE----TEELELLLKREVPLSDDDESYTDSEEAQSVNPSS 303
Query: 692 KSDSCSSDSETEDAL--EKNLINEELSLKDELEKNENLNDDKLDEENPKI--SAHILKEN 747
++ S++E + + K ++ + L L++ E +DD DEE K+ HIL++
Sbjct: 304 VDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDD--DEEINKMIDDRHILRKE 361
Query: 748 DRTQMQPLETLKLEVGENEQIVQIFGNKMEKTEEVKKEAEKSPKGKGRRSKTKDLSLEII 807
R + +P + EKT K+ EK+ K +SK + S +
Sbjct: 362 QRKENEP--------------------EAEKTHLFAKQ-EKAFYPKSFKSKKQKPSRVLY 400
Query: 808 KISSFGQNEAGSEPHIEAHSLELSSLDNKNFSSATEDEIDQCVKEK-KLKRKILGQSSPE 866
+ EA I + N + + E + K+K K+KRK+ Q+ +
Sbjct: 401 SSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNK 460
Query: 867 KKIRI---ENGMEMT--NTVSQERTSDCIGSEGMKNLNFEQHFERENEGMPSLIAESNQC 921
+ + + G E T ++ DC + + NF + F +++ L
Sbjct: 461 ENQELKQEKEGKENTRITNLTVNTGLDC-SEKTREEGNFRKSFSPKDDTSLHLFH----- 514
Query: 922 IQQLTSERFDSPAEETVNIPLKEDEDAMPLIGPETLVCHEVDLD-DLDEKDKTSIEDVAV 980
I S + E + PLK+ E + P + E+ L DL D T E +
Sbjct: 515 ISTGKSPKHSCGLSEKQSTPLKQ-EHTKTCLSPGS---SEMSLQPDLVRYDNTESEFLPE 570
Query: 981 ESSESNSLVSIPPALPPVVQHNFSVASPLTLSQDESRSVKSESDITIEVDSIAEESQEGL 1040
SS + F S + ++ SD T++ + +EG
Sbjct: 571 SSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLK-----KMDKEGK 625
Query: 1041 CERESANGFETNVASGTCSIIVQERESREKGQKRPSDGNSGLMAKKQKRTPKRTSAAAKN 1100
++ ++ +E ++ K+ +G K + S
Sbjct: 626 TLKKHK---------------LKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDR 670
Query: 1101 E--KNGTGQSSDSEDLPVLDNSSKCTPVKHLNVSKPQKLARSPARISPHIKDGEKDKHRE 1158
E K +S ++EDL LN+ +++ +IKD + K E
Sbjct: 671 EFWKENFFKSDETEDL-------------FLNMEHESLTLEKKSKLEKNIKDDKSTK--E 715
Query: 1159 KHPNSSPRTYKWSFQLNELDNMNSTERISFLQEKLQEIRK 1198
KH S R +K E D + SF +EK++++++
Sbjct: 716 KHV-SKERNFK-----EERDKIKKESEKSFREEKIKDLKE 749
>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
Length = 2062
Score = 84.3 bits (207), Expect = 6e-16
Identities = 136/685 (19%), Positives = 257/685 (37%), Gaps = 141/685 (20%)
Query: 409 TVHHHEPKVKEEKKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPR 468
T H K + K++ ++ +E+ K +E + ++K E ENI ++ +SE + + +
Sbjct: 736 TKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEE-RENIPTDKDSEFTSLGMSAIE 794
Query: 469 GRRRIARDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQK 528
+ ++ ++KEI+ EK E +K++ K
Sbjct: 795 E----SIGLHLVEKEIDIEKQEKHIKES-------------------------------K 819
Query: 529 EKKIKKQEDSDKDSDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVKYGRGKT 588
EK K+ + +KD ++ E K+ E+E+ + K + + E+D+ D+ C+ K K K T
Sbjct: 820 EKPEKRSQIKEKDIEKMERKTFEKEK-KIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHT 878
Query: 589 QKIYEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNK 648
+K ++ KS + K ++K ++K K
Sbjct: 879 EKCHKEGEKSKNTA----------------------------AIKKTDDREKSREKMDRK 910
Query: 649 EDSEKDEKRDEERQKSKRGRPPLKSTLSSNMPYGLSKTANSEGKSDSCSSDSETEDALEK 708
D EK EK + ++ K+ S N Y S+ ++ K ++ D
Sbjct: 911 HDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESI 970
Query: 709 NLINEELSLKDELEKNENLNDDKLDEENPKISAHILKENDRTQMQPLET----------- 757
N+ N + +++E +K+ ++ +K E P L ++T+ +PL+T
Sbjct: 971 NITNSK-HIQEE-KKSSIVDGNKAQHEKP------LSLKEKTKDEPLKTPDGKEKDKKDK 1022
Query: 758 ---LKLEVGENEQIVQIFGNKMEKTEEVKKEAEKSPKGKGRRSKTKDLSLEIIKISSFGQ 814
E +++ +QI K+E K + + SP K R K K L + + +SF
Sbjct: 1023 DIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSF-- 1080
Query: 815 NEAGSEPHIEAHSLELSSLDNKNFSSATEDEIDQ-----CVKEK---KLKRKILGQSSPE 866
E + LE+ K+ + E ++ C++ K K K K S
Sbjct: 1081 -----ERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKN 1135
Query: 867 KKIRIENGMEMTNTVSQERTSD----------------CIGSEGMKNLNFEQHFERENEG 910
K++ E+T+ ++E+ +G + N R
Sbjct: 1136 KELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENE 1195
Query: 911 MPSLIAESNQCIQQLTSERFDSPAEETVNIPLKEDEDAMPLIGPETLVCHEVDLDDLDEK 970
P L + S I +SE T P++ D D M L E +
Sbjct: 1196 KPGLSSRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFM-------LESSESQMSFSQSP 1248
Query: 971 DKTSIEDVAVESSESNSLVSIPPALPPVVQHNFSVASPLTLSQDESRSVKSESDITIEV- 1029
+ + A+ E +SL +P + P + S + + S ++ + + SE TIEV
Sbjct: 1249 FLSIAKSPALHERELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLIISEGRPTIEVR 1308
Query: 1030 ---------------DSIAEESQEG 1039
+I+EES +G
Sbjct: 1309 RCSMPSVICEHTKQFQTISEESNQG 1333
Score = 60.1 bits (144), Expect = 1e-08
Identities = 180/913 (19%), Positives = 349/913 (38%), Gaps = 181/913 (19%)
Query: 419 EEKKDLEESMEEALKLDQEMPLT----------EVKSEPEENIDSNSESEREEIELKSPR 468
E D+ E+ E L L +E+PL+ E +S ++D N +SE E+ L
Sbjct: 285 ERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICE- 343
Query: 469 GRRRIARDVNSIKKEIEEEKTEDKLKDNDTE--NKDVDDDY--ETAEKKENELLLGRKNT 524
++ + K + E + KD+D E NK +DD + ++KENE + +
Sbjct: 344 -----SKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHL 398
Query: 525 PKQKEK-------KIKKQEDSD---KDSDEEEEKSQEREETESKCDSEGEEDEEDMEPCL 574
++EK K KKQ+ S ++ +E++ + ++ + C E DM+
Sbjct: 399 FAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQ--- 455
Query: 575 TGTKVKVKYGRGKTQKIYEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDK 634
T+K Y S GE
Sbjct: 456 -------------TKKEYVVS--------GE----------------------------- 465
Query: 635 GGPKKKQKKKAKNKEDSEKDEKRDEERQKSKRGRPPLKST-LSSNMPYGLSKTANSEG-- 691
KQK K K K ++ K ++E ++ K G+ + T L+ N S+ EG
Sbjct: 466 ----HKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNF 521
Query: 692 ------KSD----------------SCSSDSETEDALEKNLI-------NEELSLKDELE 722
K D SC + L++ + E+SL+ +L
Sbjct: 522 RKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLV 581
Query: 723 KNENLNDDKLDEENPKISAHILKENDRTQMQPLETLKLEVGE-------NEQIVQIFGN- 774
+ +N + L E + S K ++++ Q + LE GE +E F N
Sbjct: 582 RYDNTESEFLPESS---SVKSCKHKEKSKHQ--KDFHLEFGEKSNAKIKDEDHSPTFENS 636
Query: 775 -----------------KMEKTEEVKKEAEKSPKGKGRRSKTKDLSLEIIKISSFGQNEA 817
K++ E K++ +K +G+ + KTKD + E+ + F E
Sbjct: 637 DCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEF-DREF 695
Query: 818 GSEPHIEAHSLE--LSSLDNKNFSSATEDEIDQCVK-EKKLKRKILGQSSPEKKIRIENG 874
E ++ E ++++++ + + ++++ +K +K K K + + K+ R +
Sbjct: 696 WKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIK 755
Query: 875 MEMTNTVSQERTSDCIGSEGMKNLNFEQHFERENEGMPSLIAES---NQCIQQLTSERFD 931
E + +E+ D E +N+ ++ E + GM S I ES + +++ E+ +
Sbjct: 756 KESEKSFREEKIKDL--KEERENIPTDKDSEFTSLGM-SAIEESIGLHLVEKEIDIEKQE 812
Query: 932 SPAEETVNIPLK----EDEDAMPLIGPETLVCHEVDLDDLDEKDKTSIEDVAVESSESNS 987
+E+ P K +++D + ++ + EKDK + + + E +
Sbjct: 813 KHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDK 872
Query: 988 LVS--IPPALPPVVQHNFSVASPLTLSQDESRSV---KSESDITIEVDSIAEESQEGLCE 1042
L S + + A T +++SR K + + + +AE ++ L E
Sbjct: 873 LYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLME 932
Query: 1043 ---RESANGFETNVASGTCSIIVQERESREKGQKRPSDG--NSGLMAKKQKRTPKRTSAA 1097
++S N + G +E + +EK + + S NS + +++K + + A
Sbjct: 933 KKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKA 992
Query: 1098 AKNEKNGTGQSSDSEDLPVLDNSSKCTPVKHLNVSKPQKLARSPARISPHIK-DGEKDKH 1156
+ + + E L D K K ++ K + + +I+ +K E DK
Sbjct: 993 QHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKP 1052
Query: 1157 REKHPNSSPRTYKWSFQLNELDNMNSTERISFLQEKLQEIRKYYMSLKSEVATIDRRRKR 1216
+ K +S T +L D++ T L K EI +++ K ++ ++ R R
Sbjct: 1053 KPKSSPASKDTRPKEKRLVN-DDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLR 1111
Query: 1217 ------LKKKDRE 1223
LK KD+E
Sbjct: 1112 NRNCLELKIKDKE 1124
Score = 55.5 bits (132), Expect = 3e-07
Identities = 159/821 (19%), Positives = 292/821 (35%), Gaps = 130/821 (15%)
Query: 418 KEEKKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPRGRRRIAR-D 476
K E+ D+ + M+E + +++P T P N + +S+++ + G R I+
Sbjct: 42 KIERSDVSKEMKEKSSMKRKLPFT---ISPSRNEERDSDTDSDPGHTSENWGERLISSYR 98
Query: 477 VNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLL----------GRKNTPK 526
S K+ E++KT+ + + + + Y +E+K+ LL+ N P
Sbjct: 99 TYSEKEGPEKKKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPS 158
Query: 527 QKEKKIKKQEDSDKDSDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVK---- 582
Q KK S ++ K ER ET + + ++ E G V VK
Sbjct: 159 QTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAG 218
Query: 583 ------------YGRGKTQKIYEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIW 630
Y K A + + +DD L+ G D +
Sbjct: 219 WTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSG---------HRDIVKL 269
Query: 631 PLDKGGPKKKQKKKAKNKEDSEKDEKRDEERQKSKRGRPPLKSTLSSNMPYGLSKTANSE 690
L GG + K + D + EE + + PL S +++ N
Sbjct: 270 LLRHGGNPFQANKHGERPVDVAE----TEELELLLKREVPLSDDDESYTDSEEAQSVNPS 325
Query: 691 GKSDSCSSDSETEDAL--EKNLINEELSLKDELEKNENLNDDKLDEENPKI--SAHILKE 746
++ S++E + + K ++ + L L++ E +DD DEE K+ HIL++
Sbjct: 326 SVDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDD--DEEINKMIDDRHILRK 383
Query: 747 NDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTEEVKKEAEKSPKGKGRRSKTKDLSLEI 806
R + +P + EKT K+ EK+ K +SK + S +
Sbjct: 384 EQRKENEP--------------------EAEKTHLFAKQ-EKAFYPKSFKSKKQKPSRVL 422
Query: 807 IKISSFGQNEAGSEPHIEAHSLELSSLDNKNFSSATEDEIDQCVKEK-KLKRKILGQSSP 865
+ EA I + N + + E + K+K K+KRK+ Q+
Sbjct: 423 YSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKN 482
Query: 866 EKKIRI---ENGMEMT--NTVSQERTSDCIGSEGMKNLNFEQHFERENEGMPSLIAESNQ 920
++ + + G E T ++ DC + + NF + F +++ L
Sbjct: 483 KENQELKQEKEGKENTRITNLTVNTGLDC-SEKTREEGNFRKSFSPKDDTSLHLFH---- 537
Query: 921 CIQQLTSERFDSPAEETVNIPLKEDEDAMPLIGPETLVCHEVDLD-DLDEKDKTSIEDVA 979
I S + E + PLK+ E + P + E+ L DL D T E +
Sbjct: 538 -ISTGKSPKHSCGLSEKQSTPLKQ-EHTKTCLSPGS---SEMSLQPDLVRYDNTESEFLP 592
Query: 980 VESSESNSLVSIPPALPPVVQHNFSVASPLTLSQDESRSVKSESDITIEVDSIAEESQEG 1039
SS + F S + ++ SD T++ + +EG
Sbjct: 593 ESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLK-----KMDKEG 647
Query: 1040 LCERESANGFETNVASGTCSIIVQERESREKGQKRPSDGNSGLMAKKQKRTPKRTSAAAK 1099
++ ++ +E ++ K+ +G K + S
Sbjct: 648 KTLKKHK---------------LKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFD 692
Query: 1100 NE--KNGTGQSSDSEDLPVLDNSSKCTPVKHLNVSKPQKLARSPARISPHIKDGEKDKHR 1157
E K +S ++EDL LN+ +++ +IKD + K
Sbjct: 693 REFWKENFFKSDETEDL-------------FLNMEHESLTLEKKSKLEKNIKDDKSTK-- 737
Query: 1158 EKHPNSSPRTYKWSFQLNELDNMNSTERISFLQEKLQEIRK 1198
EKH S R +K E D + SF +EK++++++
Sbjct: 738 EKHV-SKERNFK-----EERDKIKKESEKSFREEKIKDLKE 772
>gi|62865637 AT rich interactive domain 3C (BRIGHT- like) [Homo
sapiens]
Length = 412
Score = 82.8 bits (203), Expect = 2e-15
Identities = 52/171 (30%), Positives = 84/171 (49%), Gaps = 34/171 (19%)
Query: 260 VPDNWKMDISEILESSSSDDEDGPAEENDEEKEKEAKKTEEEVPEE-------------- 305
+PD+ + E + +E+ AEE DEEK +EA EE E
Sbjct: 32 LPDHRTLQAPEGALGNVGAEEEEDAEE-DEEKREEAGAEEEAAEESRPGAQGPSSPSSQP 90
Query: 306 ------------------ELDPE-ERDNFLQQLYKFMEDRGTPINKPPVLGYKDLNLFKL 346
ELD + +R FL L+ FM+ RGTP+N+ P++ + L+L+ L
Sbjct: 91 PGLHPHEWTYEEQFKQLYELDADPKRKEFLDDLFSFMQKRGTPVNRVPIMAKQVLDLYAL 150
Query: 347 FRLVYHQGGCDNIDSGAVWKQIYMDLGIPILNSAASYNVKTAYRKYLYGFE 397
FRLV +GG + + VW+++ L +P ++A++ ++T Y KYLY +E
Sbjct: 151 FRLVTAKGGLVEVINRKVWREVTRGLSLPTTITSAAFTLRTQYMKYLYPYE 201
>gi|74136549 AT rich interactive domain 5B (MRF1-like) [Homo
sapiens]
Length = 1188
Score = 78.6 bits (192), Expect = 4e-14
Identities = 65/285 (22%), Positives = 124/285 (43%), Gaps = 66/285 (23%)
Query: 296 KKTEEEVPEEELDPEERDN---FLQQLYKFMEDRGTPINKPPVLGYKDLNLFKLFRLVYH 352
K + EE P+ + E R + FL LYK+M++R TPI + P LG+K +NL+ +F+
Sbjct: 302 KVSNEEKPKVAIGEECRADEQAFLVALYKYMKERKTPIERIPYLGFKQINLWTMFQAAQK 361
Query: 353 QGGCDNIDSGAVWKQIYMDLGIPILNSAASYNVKTAYRKYLYGFEEYCRSANIQFRTVHH 412
GG + I + WK IY +LG +++A+ + Y + + +E +
Sbjct: 362 LGGYETITARRQWKHIYDELGGNPGSTSAATCTRRHYERLILPYERF------------- 408
Query: 413 HEPKVKEEKKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPRGRRR 472
+K +++ PL +K +EN +E++ + G +R
Sbjct: 409 -------------------IKGEEDKPLPPIKPRKQENSSQENENKTK------VSGTKR 443
Query: 473 IARDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPK-----Q 527
I ++ KKE K+N + +D + + ++KE E L+ +K+ P+
Sbjct: 444 IKHEIPKSKKE----------KENAPKPQDA-AEVSSEQEKEQETLISQKSIPEPLPAAD 492
Query: 528 KEKKIKKQED---------SDKDSDEEEEKSQEREETESKCDSEG 563
+KKI+ ++ D + D E ++ E+ + +G
Sbjct: 493 MKKKIEGYQEFSAKPLASRVDPEKDNETDQGSNSEKVAEEAGEKG 537
>gi|4885193 AT rich interactive domain 3A (BRIGHT- like) protein
[Homo sapiens]
Length = 593
Score = 75.5 bits (184), Expect = 3e-13
Identities = 38/115 (33%), Positives = 70/115 (60%), Gaps = 5/115 (4%)
Query: 283 PAEENDEEKEKEAKKTEEEVPEEELDPEERDNFLQQLYKFMEDRGTPINKPPVLGYKDLN 342
P + D E++ K ++ E + DP+ ++ FL L+ FM+ RGTP+N+ P++ + L+
Sbjct: 217 PPDHGDWTYEEQFK----QLYELDGDPKRKE-FLDDLFSFMQKRGTPVNRIPIMAKQVLD 271
Query: 343 LFKLFRLVYHQGGCDNIDSGAVWKQIYMDLGIPILNSAASYNVKTAYRKYLYGFE 397
LF L+ LV +GG + + +W++I L +P ++A++ ++T Y KYLY +E
Sbjct: 272 LFMLYVLVTEKGGLVEVINKKLWREITKGLNLPTSITSAAFTLRTQYMKYLYPYE 326
Score = 32.0 bits (71), Expect = 3.8
Identities = 18/67 (26%), Positives = 31/67 (46%)
Query: 505 DDYETAEKKENELLLGRKNTPKQKEKKIKKQEDSDKDSDEEEEKSQEREETESKCDSEGE 564
+D ++E+ G +P + + ++ D SDE+ + E EE E + E
Sbjct: 82 EDGPPGSEEEDAAREGTPGSPGRGREGPGEEHFEDMASDEDMKPKWEEEEMEEDLGEDEE 141
Query: 565 EDEEDME 571
E+EED E
Sbjct: 142 EEEEDYE 148
Score = 30.8 bits (68), Expect = 8.5
Identities = 18/48 (37%), Positives = 28/48 (58%), Gaps = 11/48 (22%)
Query: 525 PKQKEKKIKKQEDSDKDSDEEEEKSQEREETESKCDSEGEEDEEDMEP 572
PK +E+++ +ED +D +EEEE ++ EE EEDEE + P
Sbjct: 125 PKWEEEEM--EEDLGEDEEEEEEDYEDEEE---------EEDEEGLGP 161
>gi|56676335 RAP1 interacting factor 1 [Homo sapiens]
Length = 2472
Score = 72.4 bits (176), Expect = 3e-12
Identities = 155/748 (20%), Positives = 279/748 (37%), Gaps = 112/748 (14%)
Query: 419 EEKKDLEESMEEALKLDQEMP----LTEVKSEPEENIDSNSESEREEIELKSPRGRRRIA 474
E +K+ EES+E + L+ P TE S+ + ++ S S E + +LK+ +
Sbjct: 1309 EPEKNTEESVEGIVVLENNPPGLLNQTECVSDNQVHL-SESTMEHDNTKLKAATVENAVL 1367
Query: 475 RDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKKIKK 534
+ N+++++ E E K +T + D E + ++ +K + ++ +
Sbjct: 1368 LETNTVEEKNVEINLESK---ENTPPVVISADQMVNEDSQVQITPNQKTLRRSSRRRSEV 1424
Query: 535 QEDSDKDSDEEE--EKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVKYGRGKTQKIY 592
E + + D+E +K + R+E E ++D+ P K + I
Sbjct: 1425 VESTTESQDKENSHQKKERRKEEEKPLQKSPLHIKDDVLP--------------KQKLIA 1470
Query: 593 EASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKA-----KN 647
E +++ I+ G L+ ++ + ++ KKKA K+
Sbjct: 1471 EQTLQENLIEKGSNLH-----------------EKTLGETSANAETEQNKKKADPENIKS 1513
Query: 648 KEDSEKDEKRDEERQKSKRGRPPLKSTLSSNMPYGLSKTANSEGKSDSCSSDS--ETEDA 705
+ D +D D+ +K RGR ++ +S LS NSE S + +
Sbjct: 1514 EGDGTQDIV-DKSSEKLVRGRTRYQTRRASQGL--LSSIENSESDSSEAKEEGSRKKRSG 1570
Query: 706 LEKNLINEELSLKDELEK----------NENLNDDKLDEENPKISAHILKENDRTQMQPL 755
KN NE + ++D+ EK N++ + EE+ I + I ++ D +
Sbjct: 1571 KWKNKSNESVDIQDQEEKVVKQECIKAENQSHDYKATSEEDVSIKSPICEKQDESNTVIC 1630
Query: 756 ETLKLEVGENEQIVQIFGNKMEKTEEVKKEAEKS------PKGKGRRSKTKDLSLEIIKI 809
+ + + Q+ N E+ E K AE S P+ R T++ + K
Sbjct: 1631 QDSTV-TSDLLQVPDDLPNVCEEKNETSKYAEYSFTSLPVPESNLR---TRNAIKRLHKR 1686
Query: 810 SSFGQNEAGSEPHIEAHSLELSSLDNKNFSSATEDEIDQCVKEKKLKRKILGQSSPEKKI 869
SF G I ++SSL K F + +C Q +++
Sbjct: 1687 DSFDNCSLGESSKIGIS--DISSLSEKTFQTL------EC------------QHKRSRRV 1726
Query: 870 RIENGMEMTNTVSQERTSDCIGSEGMKNLNFE-QHFERENEGMPSLIAESNQCIQQLTSE 928
R G + SQ + IG + +N + E ++ + P +E++Q +
Sbjct: 1727 RRSKGCDCCGEKSQPQEKSLIGLKNTENNDVEISETKKADVQAPVSPSETSQANPYSEGQ 1786
Query: 929 RFDSPAEETVNIPLKEDEDAM--PLIGPETLVCHEVDLDDLDEKDKTSIEDVA-VESSES 985
D ++ LKED D + LI ET + L E++ ++SSE+
Sbjct: 1787 FLDEHHSVNFHLGLKEDNDTINDSLIVSETKSKENTMQESLPSGIVNFREEICDMDSSEA 1846
Query: 986 NSLVSIPPALPPVVQHNFSVASPLTLSQDESRSVKSESDITIEVDSIAEESQEGLCERES 1045
SL S NF P +S++V ES T E E E +
Sbjct: 1847 MSLES-----QESPNENFKTVGPCL---GDSKNVSQESLETKEEKPEETPKMELSLENVT 1898
Query: 1046 ANG-----FETNVASGTCSIIVQERESREKGQKRPSDGNSGLMA-KKQKRTPKRTSAAAK 1099
G E+N+ + E+ GQ+R G S A ++ KR + AK
Sbjct: 1899 VEGNACKVTESNLEKAKTMELNVGNEASFHGQERTKTGISEEAAIEENKRNDDSEADTAK 1958
Query: 1100 NEKNGTGQSSDSEDLPVLDNSSKCTPVK 1127
+ D+ + DN+ TPVK
Sbjct: 1959 LNAKEVATEEFNSDISLSDNT---TPVK 1983
Score = 42.4 bits (98), Expect = 0.003
Identities = 166/814 (20%), Positives = 308/814 (37%), Gaps = 116/814 (14%)
Query: 481 KKEIEEEK---TEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKKIKKQED 537
+K E+ K TE+++ + +DV +D AE E L + K E
Sbjct: 1110 RKPKEDSKMMITEEQMDSDIVIPQDVTEDCGMAEHLEKSSLSNNECGSLDKTSP----EM 1165
Query: 538 SDKDSDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVK--VKYGRGKTQKIYEAS 595
S+ ++DE ++ +T ++C S E ++ T V Y + Q
Sbjct: 1166 SNSNNDERKKALISSRKTSTECASSTENSFVVSSSSVSNTTVAGTPPYPTSRRQTF---- 1221
Query: 596 IKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDSEK-- 653
I + D E N+ VK ++ PK KQ++ +K DSEK
Sbjct: 1222 ITLEKFDGSENRPFSPSPLNNISSTVTVKNNQETMIKTDFLPKAKQREGTFSKSDSEKIV 1281
Query: 654 -DEKRDE------ERQKSKRGRPPLKS--------------TLSSNMPYGLSKTA----N 688
KR E+ +KR +P ++S L +N P L++T N
Sbjct: 1282 NGTKRSSRRAGKAEQTGNKRSKPLMRSEPEKNTEESVEGIVVLENNPPGLLNQTECVSDN 1341
Query: 689 SEGKSDSCSSDSET-------EDA--LEKNLINEELSLKDELEKNEN-----LNDDKLDE 734
S+S T E+A LE N + EE +++ LE EN ++ D++
Sbjct: 1342 QVHLSESTMEHDNTKLKAATVENAVLLETNTV-EEKNVEINLESKENTPPVVISADQMVN 1400
Query: 735 ENPKI----SAHILKENDRTQMQPLE-TLKLEVGENEQIVQIFGNKMEKTEEVKKEAEKS 789
E+ ++ + L+ + R + + +E T + + EN K E+ +E +K +KS
Sbjct: 1401 EDSQVQITPNQKTLRRSSRRRSEVVESTTESQDKENSH------QKKERRKEEEKPLQKS 1454
Query: 790 ---------PKGKGRRSKTKDLSLEIIKISSFGQNEAGSEPHIEAHSLELSSLDNKNFSS 840
PK K +T +L I K S+ + G D +N S
Sbjct: 1455 PLHIKDDVLPKQKLIAEQTLQENL-IEKGSNLHEKTLGETSANAETEQNKKKADPENIKS 1513
Query: 841 ATEDEIDQCVKEKKLKRKILGQSSPEKKIRIENGMEMTNTVSQERTSDCIGSEGMKNLNF 900
E + Q + +K ++ + G++ + + R G+ +++ + E S EG +
Sbjct: 1514 --EGDGTQDIVDKSSEKLVRGRTRYQTR-RASQGL-LSSIENSESDSSEAKEEGSRKKRS 1569
Query: 901 EQHFERENEGMPSLIAE----SNQCIQ-QLTSERFDSPAEETVNI--PLKEDEDAMPLIG 953
+ + NE + E +CI+ + S + + +EE V+I P+ E +D
Sbjct: 1570 GKWKNKSNESVDIQDQEEKVVKQECIKAENQSHDYKATSEEDVSIKSPICEKQDE----- 1624
Query: 954 PETLVCHE--VDLDDLDEKDKTSIEDVAVESSESNSLVSIPPALPPVVQHNFSVASPL-- 1009
T++C + V D L D + +V E +E++ PV + N + +
Sbjct: 1625 SNTVICQDSTVTSDLLQVPD--DLPNVCEEKNETSKYAEYSFTSLPVPESNLRTRNAIKR 1682
Query: 1010 --TLSQDESRSVKSESDITI-EVDSIAEESQEGL-CERESANGFETNVASGTCSIIVQER 1065
++ S+ S I I ++ S++E++ + L C+ + + + C Q +
Sbjct: 1683 LHKRDSFDNCSLGESSKIGISDISSLSEKTFQTLECQHKRSRRVRRSKGCDCCGEKSQPQ 1742
Query: 1066 ESREKGQKRPSDGNSGLMAKKQK--RTPKRTSAAAKNEKNGTGQSSD-----------SE 1112
E G K + + + K+ + P S ++ GQ D E
Sbjct: 1743 EKSLIGLKNTENNDVEISETKKADVQAPVSPSETSQANPYSEGQFLDEHHSVNFHLGLKE 1802
Query: 1113 DLPVLDNSSKCTPVKHLNVSKPQKLARSPARISPHIKDGEKDKHREKHPNSSPRTYKWSF 1172
D +++S + K + + L I D + + SP +
Sbjct: 1803 DNDTINDSLIVSETKSKENTMQESLPSGIVNFREEICDMDSSEAMSLESQESPNENFKTV 1862
Query: 1173 QLNELDNMN-STERISFLQEKLQEIRKYYMSLKS 1205
D+ N S E + +EK +E K +SL++
Sbjct: 1863 GPCLGDSKNVSQESLETKEEKPEETPKMELSLEN 1896
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 71.6 bits (174), Expect = 4e-12
Identities = 110/452 (24%), Positives = 188/452 (41%), Gaps = 63/452 (13%)
Query: 415 PKVKEEKKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPRGRRRIA 474
PK+K + K +EE +EE K++ E KSE EE + + +E +A
Sbjct: 444 PKLKVQHKFVEEIIEET-KVEDE------KSEMEEALTAITE---------------ELA 481
Query: 475 RDVNSIKKEIEEEKTED-KLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKKIK 533
+ KKE EEK E+ + ++ + K E KE E G K + +E+ +
Sbjct: 482 VSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEE---GEKEEEEGQEE--E 536
Query: 534 KQEDSDKDSDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVKYGRGKTQKIYE 593
++ED SD+ EE E+E + K EGE++E + E G + + K + +K E
Sbjct: 537 EEEDEGAKSDQAEEGGSEKEGSSEK--EEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEE 594
Query: 594 ASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDSEK 653
+ K + D + V E K+ P+++ G K + K S
Sbjct: 595 VATKEELVADAK-----------VEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV 643
Query: 654 DEKRDEERQKS--------KRGRPPL-KSTLSSNMPYGLSKTANSEGKSDSCSSDSETED 704
+ EE+ KS ++G+ P+ KS + + K+ E KS + E ++
Sbjct: 644 PKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKE 703
Query: 705 ALEKNLINEELSLKDELEKNENLNDD---KLDEENPKISAHILKENDRTQMQPLETLKLE 761
EK + +E ++++EK E D K E+P + + T+ + L+ E
Sbjct: 704 EEEKEV--KEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVH-LEKE 760
Query: 762 VGENEQIVQIFGNKMEKTEEVKKEAEKSPKG-KGRRSKTKDLSLEIIKISSFGQ--NEAG 818
E + +Q K + E E E S KG KG R + ++ E+ Q E G
Sbjct: 761 TKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKG 820
Query: 819 S----EPHIEAHSLELSSLDNKNFSSATEDEI 846
S E + + L+LS D K +E+++
Sbjct: 821 SGREEEKGVVTNGLDLSPADEKKGGDKSEEKV 852
Score = 53.5 bits (127), Expect = 1e-06
Identities = 79/409 (19%), Positives = 162/409 (39%), Gaps = 69/409 (16%)
Query: 414 EPKVKEEKKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPRGRRRI 473
E K E+K+ E EE ++ P+ E +E E E +E E + G +
Sbjct: 487 EKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSD 546
Query: 474 ARDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQ--KEKK 531
+ +KE EK E + ++ +TE + ++ E E+K+ E T ++ + K
Sbjct: 547 QAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAK 606
Query: 532 IKKQEDS----DKDSDEEEEKS-------QEREETESKCDSEGEEDEEDMEPCLTGTKVK 580
++K E + K EE+ KS +E+ ++ E+ + + K K
Sbjct: 607 VEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGK 666
Query: 581 VKYGRGKTQKIYEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKK 640
+ ++ ++ + + +++ + KA+ + KG K++
Sbjct: 667 SPVSKSPVEEKAKSPVPKSPVEEAK-----------------SKAE-----VGKGEQKEE 704
Query: 641 QKKKAKNKEDSEKDEKRDEERQ---KSKRGRPPLKS-------TLSSNMPYGLSKTANSE 690
++K+ K EK EK++E+ + + K+ P+K T++ ++ L K E
Sbjct: 705 EEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEE 764
Query: 691 GK-----------SDSCSSDSETEDALEKNLINEELSLKDELEKNENLNDDKLDEENPKI 739
GK S+ E D K E++++ E+E E + + +
Sbjct: 765 GKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKE------ 818
Query: 740 SAHILKENDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTEEVKKEAEK 788
K + R + + + T L++ ++ + G+K E+ V K EK
Sbjct: 819 -----KGSGREEEKGVVTNGLDLSPADE--KKGGDKSEEKVVVTKTVEK 860
Score = 52.8 bits (125), Expect = 2e-06
Identities = 89/430 (20%), Positives = 173/430 (40%), Gaps = 48/430 (11%)
Query: 473 IARDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKKI 532
I+ + K E + K + K + E V+D E +E +E + + KE+K
Sbjct: 432 ISSKIQKPKVEAPKLKVQHKFVEEIIEETKVED--EKSEMEEALTAITEELAVSMKEEKK 489
Query: 533 KKQEDSDKDSDEEEEK------------SQEREETESKCDSEGEEDEEDMEPCLTGTKVK 580
+ E+ +++ + EEE+ + +EE K + EG+E+EE+ + + +
Sbjct: 490 EAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAE 549
Query: 581 ----VKYGRGKTQKIYEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGG 636
K G + ++ + ++ +GE + +E + ++
Sbjct: 550 EGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEK 609
Query: 637 PKKKQ----KKKAKNKEDSEKDEKRDEERQKSKRGRPPLKSTLSSNMPYGLSKTANSEGK 692
P+K + K + K S + EE+ KS + P++ S +P +GK
Sbjct: 610 PEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVP---KSPVEEKGK 666
Query: 693 SDSCSS--DSETEDALEKNLINEELSLKDELEKNENLNDDKLDEENPKISAHILKENDRT 750
S S + + + + K+ + EE K E+ K E +++ + + + K+ ++
Sbjct: 667 SPVSKSPVEEKAKSPVPKSPV-EEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKP 725
Query: 751 QMQPLETLKLEVGENEQIVQIFGNKMEKTEEVKKEAEKSPKGKGRRSKTKDLSLEIIKIS 810
+ P E K E E+ V + T+ VK EK K +G K L E K
Sbjct: 726 KDVP-EKKKAESPVKEEAV---AEVVTITKSVKVHLEKETKEEG-----KPLQQEKEKEK 776
Query: 811 SFGQNEAGSEPHIEAHSLELSSLDNKNFSSATE--DEIDQCVKEKKLKRKILGQSSPEKK 868
+ G E GSE + S ++ + E +E++Q KEK G E+K
Sbjct: 777 AGG--EGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEK-------GSGREEEK 827
Query: 869 IRIENGMEMT 878
+ NG++++
Sbjct: 828 GVVTNGLDLS 837
Score = 31.6 bits (70), Expect = 5.0
Identities = 40/165 (24%), Positives = 74/165 (44%), Gaps = 12/165 (7%)
Query: 151 TEDEKEEESSEEEDEDKRRLNDELLGKVVSVVSATERTEWYPALVISPSCNDDITVKKDQ 210
TE E E E +E ++E K E + +V+ + + P SP + K
Sbjct: 571 TEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEK--PEKAKSPVPKSPVEEKGKS 628
Query: 211 CLVRSFIDSKFYS-IARKDIKEVDILNLPESELSTKPGLQKASIFLKTRVVPDNWKMDIS 269
+ +S ++ K S + + ++E +P+S P +K + V + K +
Sbjct: 629 PVPKSPVEEKGKSPVPKSPVEEKGKSPVPKS-----PVEEKGKSPVSKSPVEEKAKSPVP 683
Query: 270 EI-LESSSSDDEDGPAEENDEEKEKEAKKT--EEEVPEEELDPEE 311
+ +E + S E G E+ +EE EKE K+ EE+V ++E P++
Sbjct: 684 KSPVEEAKSKAEVGKGEQKEEE-EKEVKEAPKEEKVEKKEEKPKD 727
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 71.6 bits (174), Expect = 4e-12
Identities = 110/452 (24%), Positives = 188/452 (41%), Gaps = 63/452 (13%)
Query: 415 PKVKEEKKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPRGRRRIA 474
PK+K + K +EE +EE K++ E KSE EE + + +E +A
Sbjct: 68 PKLKVQHKFVEEIIEET-KVEDE------KSEMEEALTAITE---------------ELA 105
Query: 475 RDVNSIKKEIEEEKTED-KLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKKIK 533
+ KKE EEK E+ + ++ + K E KE E G K + +E+ +
Sbjct: 106 VSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEE---GEKEEEEGQEE--E 160
Query: 534 KQEDSDKDSDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVKYGRGKTQKIYE 593
++ED SD+ EE E+E + K EGE++E + E G + + K + +K E
Sbjct: 161 EEEDEGAKSDQAEEGGSEKEGSSEK--EEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEE 218
Query: 594 ASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDSEK 653
+ K + D + V E K+ P+++ G K + K S
Sbjct: 219 VATKEELVADAK-----------VEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV 267
Query: 654 DEKRDEERQKS--------KRGRPPL-KSTLSSNMPYGLSKTANSEGKSDSCSSDSETED 704
+ EE+ KS ++G+ P+ KS + + K+ E KS + E ++
Sbjct: 268 PKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKE 327
Query: 705 ALEKNLINEELSLKDELEKNENLNDD---KLDEENPKISAHILKENDRTQMQPLETLKLE 761
EK + +E ++++EK E D K E+P + + T+ + L+ E
Sbjct: 328 EEEKEV--KEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVH-LEKE 384
Query: 762 VGENEQIVQIFGNKMEKTEEVKKEAEKSPKG-KGRRSKTKDLSLEIIKISSFGQ--NEAG 818
E + +Q K + E E E S KG KG R + ++ E+ Q E G
Sbjct: 385 TKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKG 444
Query: 819 S----EPHIEAHSLELSSLDNKNFSSATEDEI 846
S E + + L+LS D K +E+++
Sbjct: 445 SGREEEKGVVTNGLDLSPADEKKGGDKSEEKV 476
Score = 53.5 bits (127), Expect = 1e-06
Identities = 79/409 (19%), Positives = 162/409 (39%), Gaps = 69/409 (16%)
Query: 414 EPKVKEEKKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPRGRRRI 473
E K E+K+ E EE ++ P+ E +E E E +E E + G +
Sbjct: 111 EKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSD 170
Query: 474 ARDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQ--KEKK 531
+ +KE EK E + ++ +TE + ++ E E+K+ E T ++ + K
Sbjct: 171 QAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAK 230
Query: 532 IKKQEDS----DKDSDEEEEKS-------QEREETESKCDSEGEEDEEDMEPCLTGTKVK 580
++K E + K EE+ KS +E+ ++ E+ + + K K
Sbjct: 231 VEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGK 290
Query: 581 VKYGRGKTQKIYEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKK 640
+ ++ ++ + + +++ + KA+ + KG K++
Sbjct: 291 SPVSKSPVEEKAKSPVPKSPVEEAK-----------------SKAE-----VGKGEQKEE 328
Query: 641 QKKKAKNKEDSEKDEKRDEERQ---KSKRGRPPLKS-------TLSSNMPYGLSKTANSE 690
++K+ K EK EK++E+ + + K+ P+K T++ ++ L K E
Sbjct: 329 EEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEE 388
Query: 691 GK-----------SDSCSSDSETEDALEKNLINEELSLKDELEKNENLNDDKLDEENPKI 739
GK S+ E D K E++++ E+E E + + +
Sbjct: 389 GKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKE------ 442
Query: 740 SAHILKENDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTEEVKKEAEK 788
K + R + + + T L++ ++ + G+K E+ V K EK
Sbjct: 443 -----KGSGREEEKGVVTNGLDLSPADE--KKGGDKSEEKVVVTKTVEK 484
Score = 52.8 bits (125), Expect = 2e-06
Identities = 89/430 (20%), Positives = 173/430 (40%), Gaps = 48/430 (11%)
Query: 473 IARDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKKI 532
I+ + K E + K + K + E V+D E +E +E + + KE+K
Sbjct: 56 ISSKIQKPKVEAPKLKVQHKFVEEIIEETKVED--EKSEMEEALTAITEELAVSMKEEKK 113
Query: 533 KKQEDSDKDSDEEEEK------------SQEREETESKCDSEGEEDEEDMEPCLTGTKVK 580
+ E+ +++ + EEE+ + +EE K + EG+E+EE+ + + +
Sbjct: 114 EAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAE 173
Query: 581 ----VKYGRGKTQKIYEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGG 636
K G + ++ + ++ +GE + +E + ++
Sbjct: 174 EGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEK 233
Query: 637 PKKKQ----KKKAKNKEDSEKDEKRDEERQKSKRGRPPLKSTLSSNMPYGLSKTANSEGK 692
P+K + K + K S + EE+ KS + P++ S +P +GK
Sbjct: 234 PEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVP---KSPVEEKGK 290
Query: 693 SDSCSS--DSETEDALEKNLINEELSLKDELEKNENLNDDKLDEENPKISAHILKENDRT 750
S S + + + + K+ + EE K E+ K E +++ + + + K+ ++
Sbjct: 291 SPVSKSPVEEKAKSPVPKSPV-EEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKP 349
Query: 751 QMQPLETLKLEVGENEQIVQIFGNKMEKTEEVKKEAEKSPKGKGRRSKTKDLSLEIIKIS 810
+ P E K E E+ V + T+ VK EK K +G K L E K
Sbjct: 350 KDVP-EKKKAESPVKEEAV---AEVVTITKSVKVHLEKETKEEG-----KPLQQEKEKEK 400
Query: 811 SFGQNEAGSEPHIEAHSLELSSLDNKNFSSATE--DEIDQCVKEKKLKRKILGQSSPEKK 868
+ G E GSE + S ++ + E +E++Q KEK G E+K
Sbjct: 401 AGG--EGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEK-------GSGREEEK 451
Query: 869 IRIENGMEMT 878
+ NG++++
Sbjct: 452 GVVTNGLDLS 461
Score = 31.6 bits (70), Expect = 5.0
Identities = 40/165 (24%), Positives = 74/165 (44%), Gaps = 12/165 (7%)
Query: 151 TEDEKEEESSEEEDEDKRRLNDELLGKVVSVVSATERTEWYPALVISPSCNDDITVKKDQ 210
TE E E E +E ++E K E + +V+ + + P SP + K
Sbjct: 195 TEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEK--PEKAKSPVPKSPVEEKGKS 252
Query: 211 CLVRSFIDSKFYS-IARKDIKEVDILNLPESELSTKPGLQKASIFLKTRVVPDNWKMDIS 269
+ +S ++ K S + + ++E +P+S P +K + V + K +
Sbjct: 253 PVPKSPVEEKGKSPVPKSPVEEKGKSPVPKS-----PVEEKGKSPVSKSPVEEKAKSPVP 307
Query: 270 EI-LESSSSDDEDGPAEENDEEKEKEAKKT--EEEVPEEELDPEE 311
+ +E + S E G E+ +EE EKE K+ EE+V ++E P++
Sbjct: 308 KSPVEEAKSKAEVGKGEQKEEE-EKEVKEAPKEEKVEKKEEKPKD 351
>gi|47078224 AT rich interactive domain 5A [Homo sapiens]
Length = 594
Score = 71.2 bits (173), Expect = 6e-12
Identities = 51/204 (25%), Positives = 92/204 (45%), Gaps = 26/204 (12%)
Query: 273 ESSSSDDEDGPAEENDEEKEKEAKK--TEEEVPE------EELDPEERDNFLQQLYKFME 324
+S+ D D PA K+ + + E+ PE EE + EE FL LYKFM+
Sbjct: 11 QSTEGDALDPPASPKPAGKQNGIQNPISLEDSPEAGGEREEEQEREEEQAFLVSLYKFMK 70
Query: 325 DRGTPINKPPVLGYKDLNLFKLFRLVYHQGGCDNIDSGAVWKQIYMDLGIPILNSAASYN 384
+R TPI + P LG+K +NL+K+++ V G + + +WK +Y +LG +++A+
Sbjct: 71 ERHTPIERVPHLGFKQINLWKIYKAVEKLGAYELVTGRRLWKNVYDELGGSPGSTSAATC 130
Query: 385 VKTAYRKYLYGFEEYCRSAN----------IQFRTVHHH--------EPKVKEEKKDLEE 426
+ Y + + + + + + Q++ + PK +E++ +++
Sbjct: 131 TRRHYERLVLPYVRHLKGEDDKPLPTSKPRKQYKMAKENRGDDGATERPKKAKEERRMDQ 190
Query: 427 SMEEALKLDQEMPLTEVKSEPEEN 450
M K D P EP N
Sbjct: 191 MMPGKTKADAADPAPLPSQEPPRN 214
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 70.5 bits (171), Expect = 1e-11
Identities = 88/380 (23%), Positives = 153/380 (40%), Gaps = 56/380 (14%)
Query: 416 KVKEEKKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPRGRRRIAR 475
K ++ K LEE + K QE+ K E + E ER E E + R R R
Sbjct: 283 KFRDTHKKLEEEKGKKEKERQEIE----KERRERERERERERERRERERERERERER--- 335
Query: 476 DVNSIKKEIEEEKTEDKLKDND-TENKDVDDDYETAEKKENELLLGR-KNTPKQKEKKIK 533
+KE E E+ ++ +D D T+ +D D D E ++ E R K+ + +EK
Sbjct: 336 -----EKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRD 390
Query: 534 KQEDSDKDSDEEEEKSQERE-ETESKCDSEGEEDEEDMEPCLTGTKVKVKYGRGKTQKIY 592
++ + +++ + E E+ +ERE E E + + E E + E K K + + Y
Sbjct: 391 RERERERERERERERERERERERERERERERERERE---------KDKKRDREEDEEDAY 441
Query: 593 EASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDSE 652
E ++ + E Y W +R +++K + KE
Sbjct: 442 ERRKLERKLREKEAAYQERLKNWEIR--------------------ERKKTREYEKEAER 481
Query: 653 KDEKRDEERQKSKRGRPPLKSTLSSNMPYGLSKTANSEGKSDSCSSDSETEDALEKNLIN 712
++E+R E +++KR LK L + K S+ + EK +
Sbjct: 482 EEERRREMAKEAKR----LKEFLED------YDDDRDDPKYYRGSALQKRLRDREKEMEA 531
Query: 713 EELSLKDELEKNENLNDDKLDEENPKISAHI--LKENDRTQMQPLETLKLEVGENEQIVQ 770
+E K E E+ E + L E +P A + +++ + QP + E E E+ Q
Sbjct: 532 DERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQ 591
Query: 771 IFGNKMEKTEEVKKEAEKSP 790
K E+ E ++E E+ P
Sbjct: 592 EKEEKREEPMEEEEEPEQKP 611
Score = 52.8 bits (125), Expect = 2e-06
Identities = 47/192 (24%), Positives = 91/192 (47%), Gaps = 34/192 (17%)
Query: 418 KEEKKDLEESMEEALKLDQ-EMPLTEVKSEPEENIDSNSESERE---EIELKSPRG---R 470
K++K+D EE E+A + + E L E ++ +E + + ER+ E E ++ R R
Sbjct: 427 KDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERR 486
Query: 471 RRIARDVNSIKKEIEE-----------------EKTEDKLKDNDTENKDVDDDYETAEKK 513
R +A++ +K+ +E+ ++ D+ K+ + + +D + E E+
Sbjct: 487 REMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEI 546
Query: 514 ENELLLGRKNTP--------KQKEKKIKKQEDSDKDSDEEEEKSQEREETESKCDSEGEE 565
LL P ++ E++ + Q + +S+EEEE+ QE+EE + EE
Sbjct: 547 RQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKRE--EPMEEE 604
Query: 566 DEEDMEPCLTGT 577
+E + +PCL T
Sbjct: 605 EEPEQKPCLKPT 616
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 69.7 bits (169), Expect = 2e-11
Identities = 97/426 (22%), Positives = 186/426 (43%), Gaps = 62/426 (14%)
Query: 414 EPKVKEEKKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPRGRRRI 473
E +++E++K+L E +E + + E E EE + E RE+ E K R R+
Sbjct: 320 EKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEE-KMWRQEERL 378
Query: 474 ARDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDY-ETAEKKENELLLGRKNTPKQKEKKI 532
+K++ E+ E K++D + + D+ E E+ + + + ++EKK+
Sbjct: 379 WEQ----EKQMREQ--EQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKM 432
Query: 533 KKQEDSDKDSDE---EEEKSQERE-----------ETESKCDSEGE-----EDEEDMEPC 573
++QE +D +E EEE+ +ERE E E K + E E++E +
Sbjct: 433 QEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQR 492
Query: 574 LTGTKVKV---KYGRGKTQKIYEASIKSTEIDDGEVLYLVHYYGW---NVRYDE---WVK 624
L K K+ + + + +KI+E + +I D E ++ W +R E W +
Sbjct: 493 LPEQKEKLWEQEKMQEQEEKIWE---QEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQ 549
Query: 625 ADRI------IWPLDKGGPKK--KQKKKAKNKEDSEKDEKRDEERQKSKRGRPPLKSTLS 676
+++ +W ++ KK +Q+KK ++E+ ++E+R ER+K R +
Sbjct: 550 EEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQE 609
Query: 677 SNMPYGLSKTANSEGK----SDSCSSDSETEDALEKNLINEELSL---------KDELEK 723
M K E K + E E+ + +E + K++L +
Sbjct: 610 EKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWE 669
Query: 724 NENLND-DKLDEENPKISAHILKENDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTEEV 782
+E + + +K+ E+ KI K +TQ Q +T E E+ ++ KM + EE+
Sbjct: 670 HEKMQEQEKMQEQEEKIWEQ-EKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEM 728
Query: 783 KKEAEK 788
+E E+
Sbjct: 729 MREQEE 734
Score = 55.5 bits (132), Expect = 3e-07
Identities = 61/269 (22%), Positives = 118/269 (43%), Gaps = 44/269 (16%)
Query: 406 QFRTVHHHEPKVKEEKKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELK 465
Q R E + EK +E M+E + E E K++ +E + E REE +
Sbjct: 657 QQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREE---E 713
Query: 466 SPRGRRRIARDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEK--KENELLLGRKN 523
S R R + R+ + +E EE+ E + K + E ++ +E EK ++ E + ++
Sbjct: 714 SMREREKKMREEEEMMREQEEKMQEQEEKMQEQE----EEMWEQEEKMWEQEEKMWEQQR 769
Query: 524 TPKQKEKKIKKQEDSDKDSD-EEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVK 582
P+QKEK + ++ +++ E+EEK +++EE + + EE M
Sbjct: 770 LPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKM------------ 817
Query: 583 YGRGKTQKIYEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQK 642
RG+ +K++ K W W + ++ +W ++ +K Q
Sbjct: 818 --RGQEEKMWGQEEKM----------------WGQEEKMWGQEEK-MWGQEEKMEEKMQG 858
Query: 643 KKAKNKEDSEK---DEKRDEERQKSKRGR 668
++ K +E EK E++ E+++ RG+
Sbjct: 859 QEEKMREQEEKMRGQEEKMREQEEKMRGQ 887
Score = 53.5 bits (127), Expect = 1e-06
Identities = 90/480 (18%), Positives = 207/480 (43%), Gaps = 45/480 (9%)
Query: 424 LEESM----EEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPRGRRRIARDVNS 479
L+E M EE + ++++ E K +E E + E E K R +R+
Sbjct: 270 LQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKE 329
Query: 480 IKKEIEEEKTEDKLKDNDTENKDVDD---DYETAEKKENELLLGRKNTPKQKEKKIKKQE 536
++++ +E + + +L++ + + ++ ++ + E +++ E + ++ ++EK++++QE
Sbjct: 330 LREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQE 389
Query: 537 DSDKDSD----EEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVKYGRGKTQKIY 592
+D + E++E+ +E+EE + + E+ E+ E + K++ KT+
Sbjct: 390 QKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMRE------EKKMQEQEKKTRDQE 443
Query: 593 EASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGG------PKKKQK---- 642
E + I + E + ++ K + +W ++ P++K+K
Sbjct: 444 EKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQ 503
Query: 643 KKAKNKEDS--EKDEK-RDEER---QKSKRGRPPLKSTLSSNMPYGLSKTANSEGKSDSC 696
+K + +E+ E++EK RD+E Q+ K R M K + E K
Sbjct: 504 EKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKM--- 560
Query: 697 SSDSETEDALEKNLINEELSLKDELEKNENLNDDKLDEENPKISAHILKEND---RTQMQ 753
+ E+ +EK +E D+ EK + E+ + +++E + + Q +
Sbjct: 561 ---WDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEE 617
Query: 754 PLETLKLEVGENEQIVQIFGNKMEKTEEVKKEAEKSPKGKGRRSKTKDLSLEIIKISSFG 813
++ + ++ E E+ +Q KM + EE E E+ + R + K+ E K+
Sbjct: 618 KMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQE 677
Query: 814 QNEAGSEPHIEAHSLELSSLDNKNFSSATE---DEIDQCVKEKKLKRKILGQSSPEKKIR 870
+ + E E +E + + + + E +E +EKK++ + E+K++
Sbjct: 678 KMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQ 737
Score = 44.3 bits (103), Expect = 7e-04
Identities = 89/451 (19%), Positives = 184/451 (40%), Gaps = 70/451 (15%)
Query: 152 EDEKEEESSEE--EDEDKRRLNDELLGKVVSVVSATERTEWYPALVISPSCNDDITVKKD 209
E EK +E E+ E E+K R +E+ G+ E+ W + + ++D
Sbjct: 502 EQEKMQEQEEKIWEQEEKIRDQEEMWGQ--------EKKMWR---------QEKMREQED 544
Query: 210 QCLVRSFIDSKFYSIARKDIKEVDILNLPESELSTKPGLQKASIFLKTRVVPDNWKMDIS 269
Q + + K +K + + + E K Q+ + + R+ KM
Sbjct: 545 QMWEQ---EEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREE 601
Query: 270 EILESSSSDDEDGPAEENDEEKEKEAKKTEEEVPEEELDPEERDNFLQQLYKFMEDRGTP 329
E + + E+ E++EK ++ E+ +EE E+ + +Q K E + P
Sbjct: 602 EEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLP 661
Query: 330 INKPPVLGYKDLNLFKLFRLVYHQGGCDNIDSGAVWKQIYMDLGIPILNSAASYNVKTAY 389
K + ++ + + + +W+Q M+ KT
Sbjct: 662 EQKEKLWEHEKMQEQEKMQ----------EQEEKIWEQEKME-------------KKTQE 698
Query: 390 RKYLYGFEEYCRSANIQFRTVHHHEPKVKEEKKDLEESMEEALKLDQEMPLTEVKS-EPE 448
++ +E R + ++ E K++EE++ + E E+ + +++M E + E E
Sbjct: 699 QEKKTWDQEKMR----EEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQE 754
Query: 449 ENIDSNSESEREEIELKSPRGRRRIARDVNSIKKEIEEEK---TEDKLKDNDTENKDVDD 505
E + E E+ L P + ++ +K E+EK E+K++D + + + ++
Sbjct: 755 EKMWEQEEKMWEQQRL--PEQKEKLWEH----EKMQEQEKIWEQEEKMRDQEEKMRGQEE 808
Query: 506 DYETAEKK---ENELLLGRKNTPKQKEKKIKKQEDSDKDSDEE-EEKSQEREETESKCDS 561
E+K + E + G++ +E+K+ QE+ +E+ EEK Q +EE + +
Sbjct: 809 KMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEE 868
Query: 562 EGEEDEEDMEPCLTGTKVKVKYGRGKTQKIY 592
+ EE M + + + RG+ +KIY
Sbjct: 869 KMRGQEEKM-------REQEEKMRGQEEKIY 892
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 69.7 bits (169), Expect = 2e-11
Identities = 100/493 (20%), Positives = 211/493 (42%), Gaps = 26/493 (5%)
Query: 406 QFRTVHHHEPKVKEEKKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELK 465
Q + E +++E++K+L E +E + + E E EE + E RE+ E
Sbjct: 274 QEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKM 333
Query: 466 SPRGRRRIARDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKK-ENELLLGRKNT 524
+ R ++ ++E + E+++ + D ++ ++ EK E E + +
Sbjct: 334 WRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEER 393
Query: 525 PKQKEKKIKKQEDSDKDSDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKV--- 581
+++EKK++++E++ + E+EEK Q++EE + +E++E + L K K+
Sbjct: 394 IREREKKMREEEETMR---EQEEKMQKQEENMWE-----QEEKEWQQQRLPEQKEKLWEQ 445
Query: 582 KYGRGKTQKIYEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQ 641
+ + + +KI+E + +I D E ++ W R ++ + + +W ++ ++Q
Sbjct: 446 EKMQEQEEKIWE---QEEKIRDQEEMWGQEKKMW--RQEKMREQEDQMWEQEEKMRDQEQ 500
Query: 642 KKKAKNKEDSEKDEKRDEERQKSKRGRPPLKSTLSSNMPYGLSKTANSEGKSDSCSSDSE 701
K + + E+DE+ R+K +R R K KT E K+
Sbjct: 501 KMWDQEERMWEQDERL---REKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMR 557
Query: 702 TEDAL---EKNLINEELSLKDELEKNENLNDDKLDEENPKISAHILKENDRTQMQPLETL 758
E+ + EK + EE ++++ EK + ++K+ E+ K+ K ++ + +
Sbjct: 558 EEERMREREKKMREEEEMMREQEEKMQE-QEEKMREQEEKMWEQEEKMQEQEEKMWEQEE 616
Query: 759 KLEVGENEQIVQIFGNKMEKTEEVKKEAEKSPKGKGRRSKTKDLSLEIIKISSFGQNEAG 818
K+ E E +Q M + EE +E E+ + + + ++ + + GQ E
Sbjct: 617 KMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKM 676
Query: 819 SEPHIEAHSLELSSLDNKNFSSATEDEI-DQCVKEKKLKRKILGQSS-PEKKIRIENGME 876
E + E + + E+++ Q K + K+ GQ EK+ RI + E
Sbjct: 677 REQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKE 736
Query: 877 MTNTVSQERTSDC 889
E C
Sbjct: 737 KMQERLPEHEERC 749
Score = 57.0 bits (136), Expect = 1e-07
Identities = 59/266 (22%), Positives = 119/266 (44%), Gaps = 47/266 (17%)
Query: 414 EPKVKEEKKDLEES-----MEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPR 468
E K++EEKK E+ EE ++ ++ M E K EE + E + +E E K
Sbjct: 533 EEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKM-- 590
Query: 469 GRRRIARDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQK 528
R+ E EE+ E + K + E K + + E +++ E++ ++ +++
Sbjct: 591 ------REQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQ 644
Query: 529 EKKIKKQEDSDKDSDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVKYGRGKT 588
E+K+ +QE+ + E+EEK +E+EE + + E EE M+ + + + RG+
Sbjct: 645 EEKMWEQEEKMR---EQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQE 701
Query: 589 QKIYEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNK 648
+K+ W W + ++ +W G ++ ++K+ + +
Sbjct: 702 EKM-----------------------WGQEEKMWGQEEK-MW-----GQEEMREKEERIR 732
Query: 649 EDSEKDEKR--DEERQKSKRGRPPLK 672
+ EK ++R + E + S+ PP K
Sbjct: 733 DQKEKMQERLPEHEERCSEPCLPPSK 758
Score = 50.1 bits (118), Expect = 1e-05
Identities = 39/181 (21%), Positives = 87/181 (48%), Gaps = 7/181 (3%)
Query: 406 QFRTVHHHEPKVKEEKKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESER---EEI 462
Q + E K++E+++ + E E+ + +++M E K +E D E E E+
Sbjct: 579 QEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQE 638
Query: 463 ELKSPRGRRRIARDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKK---ENELLL 519
E + + ++ ++E + + E+K++ + + ++ ++ + E+K + E +
Sbjct: 639 EKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMR 698
Query: 520 GRKNTPKQKEKKIKKQEDSDKDSDEEEEKSQE-REETESKCDSEGEEDEEDMEPCLTGTK 578
G++ +E+K+ QE+ +E EK + R++ E + E +E EPCL +K
Sbjct: 699 GQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHEERCSEPCLPPSK 758
Query: 579 V 579
V
Sbjct: 759 V 759
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 68.6 bits (166), Expect = 4e-11
Identities = 109/511 (21%), Positives = 185/511 (36%), Gaps = 105/511 (20%)
Query: 433 KLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPRGRRRIARDVNSIKKEIEEEKTEDK 492
KL P+ + + + DS SE EE E++ P ++ V + + + K K
Sbjct: 67 KLQANGPVAKKAKKKASSSDSEDSSEEEE-EVQGPPAKKAA---VPAKRVGLPPGKAAAK 122
Query: 493 LKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKKIKKQEDSDKDSDEEEEKSQER 552
++ + + DDD E +KK+ + G K K + KK + SD DSD E
Sbjct: 123 ASESSSSEESSDDDDEEDQKKQ-PVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSE----- 176
Query: 553 EETESKCDSEGEEDEEDMEPCLTGTKVKV-------------KYGRGKTQKIYEASIKST 599
+E ++ +P +T VK K GK +S S+
Sbjct: 177 -----------DEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSS 225
Query: 600 EIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKK------------QKKKAKN 647
DD E ++ K PKK+ +K+ +
Sbjct: 226 SSDDSE-------------------EEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSS 266
Query: 648 KEDSEKDEKRDEER-QKSKRG---------RPPLKSTLSSNMPYGL----SKTANSEGKS 693
EDS DE+ ++++ K+K G PP K +L + P +SE S
Sbjct: 267 SEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSS 326
Query: 694 DSCSSDSETEDALEKNLINEELSLKD-------ELEKNENLNDDKLDEENPKISAHILKE 746
D S SE E + + + K E + + +D D+E P A K
Sbjct: 327 DESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKN 386
Query: 747 NDR--------TQMQPLETLKLEVGENEQIVQIFGNKMEKTEEVKKEAEKSPKGKGRRSK 798
+ ++P K VG ++++ + EE E+ K +K
Sbjct: 387 SSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTK 446
Query: 799 TKDLSLEIIKISSFGQNEAGSEPHIEAHSLELSSLDNKNFSSATEDEIDQCVKEKKLKRK 858
K + + + + Q GS SS D+ + SS E+E KK +K
Sbjct: 447 PKATAKAALSLPA-KQAPQGSRD---------SSSDSDSSSSEEEEEKTSKSAVKKKPQK 496
Query: 859 ILGQSSPEKKIRIENG-MEMTNTVSQERTSD 888
+ G ++P K + G E +N+ S + +S+
Sbjct: 497 VAGGAAPSKPASAKKGKAESSNSSSSDDSSE 527
Score = 53.1 bits (126), Expect = 2e-06
Identities = 125/655 (19%), Positives = 241/655 (36%), Gaps = 99/655 (15%)
Query: 619 YDEWVKADRIIW-PLDKGGPKKKQKKKAKNKEDSEKDEKRDEERQ--KSKRGRPPLKSTL 675
Y W+K+ ++ L GP K+ KK + DSE + +EE Q +K+ P K
Sbjct: 54 YSFWLKSAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRV- 112
Query: 676 SSNMPYGLSKTANSEGKSDSCSSDSETEDALEKNLINE-------------ELSLKDELE 722
+P G + SE S SSD + E+ +K + + + + + +
Sbjct: 113 --GLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSD 170
Query: 723 KNENLNDDKLDEENPKISAHILKENDRTQMQPLETL-KLEVGENEQIVQIFGNKMEKTEE 781
+ + D+ + PKI+ +K + +P K+ G+ + +
Sbjct: 171 SDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDS 230
Query: 782 VKKEAEKSPKGKGRRSKTKDLSLEIIKISSFGQNEAGSEPHIEAHSLELSSLDNKNFSSA 841
+++A +PK KT + K +A + P ++ S E SS D
Sbjct: 231 EEEKAAATPK------KTVPKKQVVAK----APVKAATTPTRKSSSSEDSSSDE------ 274
Query: 842 TEDEIDQCVKEK------------KLKRKILGQSSPEKKIRIENGMEMTNTVSQER---- 885
E+E + +K K +K LG P+K + + +E + S E
Sbjct: 275 -EEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSS 333
Query: 886 -------TSDCIGSEGMKNLNFEQHFERENEGMPSLIAESNQCIQQ---LTSERFDSPAE 935
T + K ++ E ++ S +E ++ + T + PA
Sbjct: 334 EEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAV 393
Query: 936 ETVNIPLK-EDEDAMPLIGPETLVCHEVDLDDLDEKDKTSIED-------VAVESSESNS 987
T + +K P+ G + L+ + D +E+ +S E+ + + +
Sbjct: 394 TTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKA 453
Query: 988 LVSIPPALPPVVQHNFSVASPLTLSQDESRSVKSESDITIEVDSIAEESQEGL-CERESA 1046
+S+P P + S S + S++E S+S + + +A + +
Sbjct: 454 ALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKT-SKSAVKKKPQKVAGGAAPSKPASAKKG 512
Query: 1047 NGFETNVASGTCSIIVQERESREKGQKRP----SDGNSGLMAK-------KQKRTPKRTS 1095
+N +S S +E + + KG RP ++G S L A+ ++ ++
Sbjct: 513 KAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKK 572
Query: 1096 AAAKNEKNGT------GQSSDSEDLPVLDNSSKCTPVKHLNVSKPQKLARSPARISPHIK 1149
AA K+G+ +++ + P TP K +K A SP R ++
Sbjct: 573 AAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGEKRASSPFR---RVR 629
Query: 1150 DGEKDKHREKHPNS----SPRTYKWSFQLNELDNMNSTERISFLQEKLQEIRKYY 1200
+ E + NS W + N++ + T+ SF EK ++ R Y
Sbjct: 630 EEEIEVDSRVADNSFDAKRGAAGDWGERANQV--LKFTKGKSFRHEKTKKKRGSY 682
Score = 32.7 bits (73), Expect = 2.2
Identities = 21/111 (18%), Positives = 49/111 (44%), Gaps = 6/111 (5%)
Query: 445 SEPEENIDSNSESEREEIELKSPRGRRRIARDVNSIKKEIEEEKTEDKLKDNDTENKDVD 504
S EE+ S E ++ + P+ + A S+ + + + D D+D+ + + +
Sbjct: 425 SSEEESSSSEEEKTKKMVATTKPKATAKAAL---SLPAKQAPQGSRDSSSDSDSSSSEEE 481
Query: 505 DDYET---AEKKENELLLGRKNTPKQKEKKIKKQEDSDKDSDEEEEKSQER 552
++ + +KK ++ G + KK K + + SD+ E+ +E+
Sbjct: 482 EEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEK 532
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 68.6 bits (166), Expect = 4e-11
Identities = 165/890 (18%), Positives = 346/890 (38%), Gaps = 149/890 (16%)
Query: 416 KVKEEKKDLEESMEEALKLDQEMPLTEV--KSEPEENIDSNSESEREEIELKSPRGRRRI 473
K++ +++LEE E+ L QE+ E+ K +EN++ S++ + R
Sbjct: 259 KIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREK 318
Query: 474 ARDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKKIK 533
A V+ ++ E+ K ++L D + V++ K++N++LL K + + + +
Sbjct: 319 AVRVDKLESEVSRYK--ERLHDIEFYKARVEE-----LKEDNQVLLETKTMLEDQLEGTR 371
Query: 534 KQEDSDKDSDEEEEKSQER-EETESKCDSEGEEDEEDMEPCLTGTKVKVKYGR------- 585
+ D + ++E + + + + E + D + ++ EE ME +T ++ K
Sbjct: 372 ARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMT-LEMAQKQSMDESLHLG 430
Query: 586 ------GKTQKIYEASIKST--EIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGP 637
+T ++ EA KS E+++ L+ N + V+ R +G
Sbjct: 431 WELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNA 490
Query: 638 KKKQKKKAKNKEDSEKDEKRDEERQKSKRGRPPLKSTLSSNMPYGLSKTANSEGKSDSCS 697
K K + +N+ S+K E + E + K+ ++ LSK D
Sbjct: 491 SKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQN---------LSK--------DLMK 533
Query: 698 SDSETEDALEKNLINEELSLKDELEKNENLNDDKLD-EENPKISAH-----------ILK 745
++ E +E N E +K ++NE+LN + +ISA IL
Sbjct: 534 EKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILH 593
Query: 746 ENDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTEEVKKEAEKSPK-GKGRRSKTKDLSL 804
E+ + L ++ E + ++ ++ + K E+ EE++ E K + + K +L +
Sbjct: 594 ESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKI 653
Query: 805 EIIKISSFGQNEAGSEPH-----------------IEAHSLELSSLDNKNFSSATEDEID 847
KI + Q + E +E+ E S LD +N E
Sbjct: 654 TCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESL 713
Query: 848 QCVKEKKLKRKILGQSSPEKKIRIENGMEMTNTVSQERTSDCIGSEGMKNLNFEQHFERE 907
+C K + ++ + +K +++ G+E+ ++ + +G+ + E
Sbjct: 714 KCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGL---------DIE 764
Query: 908 NEGMPSLIAESNQCIQQLTSERFDSPAEETVNIPLKEDEDAMPLIGPETLVCHEVDLDDL 967
N+ + + SN+ IQQL SE D E N L+++ + + + L+ L
Sbjct: 765 NQRLQKTLENSNKKIQQLESELQDLEME---NQTLQKNLEELKISSKR--------LEQL 813
Query: 968 DEKDKTSIEDVAVESSESNSLVSIPPALPPVVQHNFSVASPLTLSQDESRSVKSESDITI 1027
++++K+ ++ + + L + E++ ++ +++I
Sbjct: 814 EKENKSLEQETSQLEKDKKQL------------------------EKENKRLRQQAEIK- 848
Query: 1028 EVDSIAEESQEGLCERESANGFETNVASGTCSIIVQERESREKGQKRPSDGNSGLMAKKQ 1087
D+ EE+ + E N + S+E G + S + K+
Sbjct: 849 --DTTLEENNVKIGNLEKEN----------------KTLSKEIGIYKESCVRLKELEKEN 890
Query: 1088 KRTPKRTSAAAKNEKNGTGQSSDSEDLPVLDNSSKCTPVKHLNVSKPQKLARSPARISPH 1147
K KR + K + SE L ++ + H + +K+ + R+ H
Sbjct: 891 KELVKRATIDIKTLVT-LREDLVSEKLKTQQMNNDLEKLTH----ELEKIGLNKERLL-H 944
Query: 1148 IKDGEKDKHREKHPNSSPRTYKWSFQLNELDNMNSTERISFLQEKLQEIRKYYMSLKSEV 1207
+ D + + T K S ++ E E+I+ L+ +L+E Y L+ E+
Sbjct: 945 DEQSTDDSRYKLLESKLESTLKKSLEIKE-------EKIAALEARLEESTNYNQQLRQEL 997
Query: 1208 ATIDRRRKRLKKKDREVSHAGASMSSASSDTGMSPSSSSPPQNVLAVECR 1257
T+ + + LK++ E +S + D S + +L V+ R
Sbjct: 998 KTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDR 1047
Score = 49.7 bits (117), Expect = 2e-05
Identities = 122/569 (21%), Positives = 226/569 (39%), Gaps = 49/569 (8%)
Query: 704 DALEKNLINEELSLKDELEK-NENLNDD-KLDEENPKISAHILKENDRTQMQPLETLKLE 761
D + N + +++ K E ++ N+ +N+D L N I +K + +Q L + L
Sbjct: 44 DGVFLNQVMLQINPKLESQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLP 103
Query: 762 VGENEQIVQIFGNKMEKTEEVKKEAEKSPKGKGRRSKTKDLSLEIIKISSFGQNEAGSEP 821
N I+ + TEEVKK G + + K+ +E I+ F +A
Sbjct: 104 ---NVLIIGKNPFSEQGTEEVKKLLLLL-LGCAVQCQKKEEFIERIQGLDF-DTKAAVAA 158
Query: 822 HIE--AHSLE-LSSLDNKNFSSATEDEIDQCVKEKKLKRKILGQSSPEKKIRI------E 872
HI+ H+ E + L + ++++I+ +K L K L E I
Sbjct: 159 HIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEER 218
Query: 873 NGMEMTNTVSQERTSDCIGSEGMKNLNFEQHFERENEGMPSLIAESNQCIQQLTSERFDS 932
+G+ S S C GS GMK QH E + I Q +++ T + D
Sbjct: 219 DGLHFLPHASSSAQSPC-GSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDC 277
Query: 933 PAE-ETVNIPLK--EDEDAMPLIGPETLVCHEVDLDDLDEK----DKTSIEDVAVESSES 985
E E + I LK + E+ L + + +LD L EK DK E V+
Sbjct: 278 KQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESE-VSRYKERL 336
Query: 986 NSLVSIPPALPPVVQHNFSVASPLTLSQDESRSVKSESDITIEVDSIAEESQEGLCERES 1045
+ + + + + N + T+ +D+ ++ SD E++ + + L + E
Sbjct: 337 HDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDME- 395
Query: 1046 ANGFETNVASGTCSIIVQERESREKGQKRPSDG--NSGLMAKKQKRTPKRTSAAAKNEKN 1103
E ++ +++E + E QK+ D + G ++ RT + + A K+ +
Sbjct: 396 ---MERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGH 452
Query: 1104 GTGQSSDSEDLPV-LDNSSKCTPVKHL---------NVSKPQKLARSPARISPHIKDGEK 1153
+ + S L + ++N S V+ L N SK K+ + R+S ++ E
Sbjct: 453 EVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILEN 512
Query: 1154 DKHREKH-----PNSSPRTYKWSFQLN---ELDNMNSTERISFLQEKLQEIRKYYMSLKS 1205
+ +EK N S K QL E NS +I L+++ + + + SL+
Sbjct: 513 EIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQ 572
Query: 1206 EVATIDRRRKRLKKKDREVSHAGASMSSA 1234
R + +K+ ++ H +S+
Sbjct: 573 RSQISAEARVKDIEKENKILHESIKETSS 601
Score = 32.0 bits (71), Expect = 3.8
Identities = 77/409 (18%), Positives = 144/409 (35%), Gaps = 56/409 (13%)
Query: 408 RTVHHHEPKVKEEKKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSP 467
R +H + K LE +E LK E+ ++ + +S + +++ ELK+
Sbjct: 941 RLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKT- 999
Query: 468 RGRRRIARDVNSIKKEIEEEKTEDKL-----KDNDTENKDVDDDYETAEKKENELLLGRK 522
+ ++ ++K+ +EE+ +DN E + + E + K+ + + R
Sbjct: 1000 -----VKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERN 1054
Query: 523 NTPKQKEKKIKKQEDSDKDSDEEEEKSQ-----------EREETESKCDSEGEEDE---- 567
N Q EK+ K + ++ ++Q + + T + + + E
Sbjct: 1055 NATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTL 1114
Query: 568 EDMEPCLTGTKVKVKYGRGKTQKIYEASIKSTE---------IDDGEVLYLVHYYGWNVR 618
L ++ + + E+ IK E I D E L L+H
Sbjct: 1115 NSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHER----- 1169
Query: 619 YDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDSEKD-EKRDEERQKSKRGRPPLKSTLSS 677
+A + K G K KN E +D E R + K K L+ L
Sbjct: 1170 -----QASEYESLISKHGTLKSAH---KNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKV 1221
Query: 678 NMPYGLSKTANSEGKSDS----CSSDSETEDALEKNLINEELSLKDELEKNENLNDDKLD 733
L + N E + C + + L E+ D LN+ KL
Sbjct: 1222 EQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKL- 1280
Query: 734 EENPKISAHILKENDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTEEV 782
E ++ A K ++ Q + + KL + E + Q+ GN E+ +
Sbjct: 1281 -EQTRLEAEFSKLKEQYQQLDITSTKLN-NQCELLSQLKGNLEEENRHL 1327
>gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sapiens]
Length = 1758
Score = 68.2 bits (165), Expect = 5e-11
Identities = 169/821 (20%), Positives = 307/821 (37%), Gaps = 116/821 (14%)
Query: 417 VKEEKKDLE----ESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPRG--- 469
V++E D E +S+ E K +++ P + +N D ++ S++E I +K +G
Sbjct: 952 VRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKN-DGSAVSKKENI-VKPAKGPQE 1009
Query: 470 -----RRRIARDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNT 524
R R R IKK EE D K + + KD + T K ++ + T
Sbjct: 1010 KVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKD-EKITGTPRKAHSKSAKEHQET 1068
Query: 525 PKQKEKKIKKQEDSDKDSDE---EEEKSQEREETESKCDSEGEE-----DEEDMEPCLTG 576
KE+K+KK D S++ +EEK+++ E D++GE+ +E+ ++
Sbjct: 1069 KPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFES 1128
Query: 577 TKVKVKYGRGKTQKIYEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIW--PLDK 634
+ +K+ + + +I + S K D E + D + D+I P K
Sbjct: 1129 SSMKIS--KLEVTEIVKPSPKRKMEPDTE------------KMDRTPEKDKISLSAPAKK 1174
Query: 635 GGPKKKQKKK-------AKNKEDSEKDE----KRDEERQKSKRGRPPLKSTLSSNMPYGL 683
++ KK + KE SEK E K +E+ K K R + SS+
Sbjct: 1175 IKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDY 1234
Query: 684 SKTANSEG----KSDSCSSDSETEDALEKNLINEELSLKDELEKNENLNDDKLDEENPKI 739
+ T+++ G KS+ + T + N+ + +++ + K D+++ +
Sbjct: 1235 TSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFES 1294
Query: 740 SAHILKENDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTEEVKKEAEKSPKGKGRRSK- 798
+E D QP+ + VG+ +++ N K + K EK + + K
Sbjct: 1295 -----EEEDVKSTQPISS----VGKPASVIK---NVSTKPSNIVKYPEKESEPSEKIQKF 1342
Query: 799 TKDLSLEIIKISSFGQNEAGSEPHIEAHSLELSSLDNKNFSSATEDEIDQCVKEKKLKR- 857
TKD+S EII+ + S + + S L+ +N Q KE L R
Sbjct: 1343 TKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNST--QPEKESNLDRL 1400
Query: 858 ------KILGQSSPEKKI-------RIENGMEMTNTVSQERTSDCIGSEGMKNLNFEQHF 904
K L QSS E + R + + T ++ D K + +
Sbjct: 1401 NEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNEL 1460
Query: 905 ERENEGMPSLIAESNQCIQQLTSERFDSPAEETVNIPLKEDEDAMPLIGPETLVCHE--- 961
R + PS +S + E D P + T + + + ++
Sbjct: 1461 TRRKDS-PSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKR 1519
Query: 962 -------VDLDDLDEKDKTSIEDVAVESSESNSLVSI--PPALPPVVQHNFSVASPLTLS 1012
VD + +++K +E + S N L+ I PP + T+
Sbjct: 1520 PNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVK 1579
Query: 1013 QDE--SRSVKSESDITIEVDSIAEESQEGLCERESANGFETNVASGTCS------IIVQE 1064
S S + SD+T E D A E + ES + +SG S I+ +
Sbjct: 1580 PKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKA 1639
Query: 1065 RESREK------GQKRPSDGNSGLMAKKQKRTPKRTSAAAKNEKNGTGQSSDSEDLPVLD 1118
+ES + G R +S ++ + +P + + + + +S DS+
Sbjct: 1640 KESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSK------ 1693
Query: 1119 NSSKCTPVKHLNVSKPQKLARSPARISPHIKDGEKDKHREK 1159
K K K K + A ++ +K KH++K
Sbjct: 1694 KKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKK 1734
Score = 52.4 bits (124), Expect = 3e-06
Identities = 117/533 (21%), Positives = 200/533 (37%), Gaps = 92/533 (17%)
Query: 415 PKVKEEKKDLEESMEEALKLDQEM-----PLTEVK--SEPEENIDSNSESEREEIELKSP 467
P+ K +K D E S EE +K Q + P + +K S NI E E E E
Sbjct: 1283 PQSKWDKDDFE-SEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSE---- 1337
Query: 468 RGRRRIARDVNSIKKEI-EEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPK 526
+I + + EI + E K + + K D DY EK+ E RKN+
Sbjct: 1338 ----KIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPE---KRKNS-T 1389
Query: 527 QKEKKIKKQEDSDKDSDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVKYGRG 586
Q EK+ +++ + + +S + T K DS +D P
Sbjct: 1390 QPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTP-------------- 1435
Query: 587 KTQKIYEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAK 646
K T+ D E Y + R DE + R +K + K
Sbjct: 1436 -------NRDKKTDYDTRE-------YSSSKRRDEKNELTR----------RKDSPSRNK 1471
Query: 647 NKEDSEKDEKRDEERQKSKRGRPPLKSTLSSNMPYGLSKTANSEGKSDSCSSDSETEDAL 706
+ +K++ R EER K+G K + SS P K + + D+ + ET+ ++
Sbjct: 1472 DSASGQKNKPR-EERDLPKKGTGDSKKSNSS--PSRDRKPHDHKATYDTKRPNEETK-SV 1527
Query: 707 EKNLINEE----LSLKDELEKNEN-----LNDDKLDEENPKISAHILKENDRTQMQPLET 757
+KN + L ++ E + N LN + E +I+ I K + + Q +
Sbjct: 1528 DKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHS 1587
Query: 758 LKL-------------EVGENEQIVQIFGNKMEKTEEVKKEAEKSPKGKGRRSKTKDLSL 804
+L E NE + N K EE K K K + L
Sbjct: 1588 SRLSSDLTRETDEAAFEPDYNESDSE--SNVSVKEEESSGNISKDLKDKIVEKAKESLDT 1645
Query: 805 EIIKISSFGQNEAGSEPHI---EAHSLELSSLDNKNFSSATEDEIDQCVKEKKLKRKILG 861
+ +N++ S P + +HS S + + S+++ + D K+KK ++K
Sbjct: 1646 AAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHK 1705
Query: 862 QSSPEKKIRIENGMEMTNTVSQERTSDCIGSEGMKNLNFEQHFERENEGMPSL 914
+ KK + G E+ SQ+ + KN + E+ E++++ + S+
Sbjct: 1706 KHKKHKKHKKHAGTEVELEKSQKHKHK--KKKSKKNKDKEKEKEKDDQKVKSV 1756
Score = 52.0 bits (123), Expect = 4e-06
Identities = 131/695 (18%), Positives = 250/695 (35%), Gaps = 100/695 (14%)
Query: 529 EKKIKKQEDSDKDSDEEEEKSQEREETESKCDS--------EGEEDEEDMEPCLTGTKVK 580
EK + + KD+ + +EK E + K + +GEE E + P L T K
Sbjct: 866 EKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRK 925
Query: 581 VKYGRGKTQKIYEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKK 640
+ G + ++ DD + ++ + + D+ ++ PK K
Sbjct: 926 SREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDK----RERDKPKAK 981
Query: 641 -QKKKAKN-------KEDSEK-----DEKRDEERQKSKRGRPPLKSTLSSNMPYGLSKTA 687
K K KN KE+ K EK D ER++S R PP+K +K++
Sbjct: 982 GDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSS 1041
Query: 688 NSEGK------------SDSCSSDSETEDALE--------KNLINEELSLKDELEKNENL 727
+S K S S ET+ E K++ +E+L+ K+E K N
Sbjct: 1042 SSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNE 1101
Query: 728 NDDKLDEENPKISAHILK-------ENDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTE 780
+ LD + K + E+ ++ LE ++ ++ ++ KM++T
Sbjct: 1102 KNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTP 1161
Query: 781 EVKKEAEKSPKGKGRRSKTKDLSLEIIKISSFGQNEAGSEPHIEAHSLELSSLDNKNFSS 840
E K + +P K IK++ + GS +I L+
Sbjct: 1162 EKDKISLSAPAKK-------------IKLNRETGKKIGSTENISNTKEPSEKLE------ 1202
Query: 841 ATEDEIDQCVKEKKLKRKILGQSSPEKKIRIENGMEMTNTVSQERTSDCIGSEGMKNLNF 900
+T ++ Q + K++RK+ G + ++ + S R S+ +
Sbjct: 1203 STSSKVKQEKVKGKVRRKVTGTEGSSSTL-VDYTSTSSTGGSPVRKSEEKTDTKRTVIKT 1261
Query: 901 EQHFERENEGMPSLIAESNQCIQQLTSERFDSPAEETVNIPLKEDEDAMPLIGPETLVCH 960
+ + +N + AE + Q+ ++D E+ +K + + P +++
Sbjct: 1262 MEEYNNDN----TAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVI-- 1315
Query: 961 EVDLDDLDEKDKTSIEDVAVESSESNSLVSIPPALP-PVVQHNFSVASPLTLSQDESRSV 1019
++ K ++ ES S + + ++QH V S + E
Sbjct: 1316 ----KNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQH--EVKSSKNSASSEKGKT 1369
Query: 1020 KSESDITIEVDSIAEESQEGLCERESANGFETNVASGTCSIIVQERESR--EKGQKRPSD 1077
K +E ++ + E+ES N N S+ +E+R +K +
Sbjct: 1370 KDRDYSVLEKENPEKRKNSTQPEKES-NLDRLNEQGNFKSLSQSSKEARTSDKHDSTRAS 1428
Query: 1078 GNSGLMAKKQKRTPKRT----SAAAKNEKNGTGQSSDSEDLPVLDNSSKCTPVKHLNVSK 1133
N + K+T T S+ ++EKN + DS N + K +K
Sbjct: 1429 SNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPS----RNKDSASGQK----NK 1480
Query: 1134 PQKLARSPARISPHIKDGEKDKHREKHPNSSPRTY 1168
P++ P + + K R++ P+ TY
Sbjct: 1481 PREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATY 1515
>gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sapiens]
Length = 1792
Score = 68.2 bits (165), Expect = 5e-11
Identities = 169/821 (20%), Positives = 307/821 (37%), Gaps = 116/821 (14%)
Query: 417 VKEEKKDLE----ESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPRG--- 469
V++E D E +S+ E K +++ P + +N D ++ S++E I +K +G
Sbjct: 986 VRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKN-DGSAVSKKENI-VKPAKGPQE 1043
Query: 470 -----RRRIARDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNT 524
R R R IKK EE D K + + KD + T K ++ + T
Sbjct: 1044 KVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKD-EKITGTPRKAHSKSAKEHQET 1102
Query: 525 PKQKEKKIKKQEDSDKDSDE---EEEKSQEREETESKCDSEGEE-----DEEDMEPCLTG 576
KE+K+KK D S++ +EEK+++ E D++GE+ +E+ ++
Sbjct: 1103 KPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFES 1162
Query: 577 TKVKVKYGRGKTQKIYEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIW--PLDK 634
+ +K+ + + +I + S K D E + D + D+I P K
Sbjct: 1163 SSMKIS--KLEVTEIVKPSPKRKMEPDTE------------KMDRTPEKDKISLSAPAKK 1208
Query: 635 GGPKKKQKKK-------AKNKEDSEKDE----KRDEERQKSKRGRPPLKSTLSSNMPYGL 683
++ KK + KE SEK E K +E+ K K R + SS+
Sbjct: 1209 IKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDY 1268
Query: 684 SKTANSEG----KSDSCSSDSETEDALEKNLINEELSLKDELEKNENLNDDKLDEENPKI 739
+ T+++ G KS+ + T + N+ + +++ + K D+++ +
Sbjct: 1269 TSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFES 1328
Query: 740 SAHILKENDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTEEVKKEAEKSPKGKGRRSK- 798
+E D QP+ + VG+ +++ N K + K EK + + K
Sbjct: 1329 -----EEEDVKSTQPISS----VGKPASVIK---NVSTKPSNIVKYPEKESEPSEKIQKF 1376
Query: 799 TKDLSLEIIKISSFGQNEAGSEPHIEAHSLELSSLDNKNFSSATEDEIDQCVKEKKLKR- 857
TKD+S EII+ + S + + S L+ +N Q KE L R
Sbjct: 1377 TKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNST--QPEKESNLDRL 1434
Query: 858 ------KILGQSSPEKKI-------RIENGMEMTNTVSQERTSDCIGSEGMKNLNFEQHF 904
K L QSS E + R + + T ++ D K + +
Sbjct: 1435 NEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNEL 1494
Query: 905 ERENEGMPSLIAESNQCIQQLTSERFDSPAEETVNIPLKEDEDAMPLIGPETLVCHE--- 961
R + PS +S + E D P + T + + + ++
Sbjct: 1495 TRRKDS-PSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKR 1553
Query: 962 -------VDLDDLDEKDKTSIEDVAVESSESNSLVSI--PPALPPVVQHNFSVASPLTLS 1012
VD + +++K +E + S N L+ I PP + T+
Sbjct: 1554 PNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVK 1613
Query: 1013 QDE--SRSVKSESDITIEVDSIAEESQEGLCERESANGFETNVASGTCS------IIVQE 1064
S S + SD+T E D A E + ES + +SG S I+ +
Sbjct: 1614 PKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKA 1673
Query: 1065 RESREK------GQKRPSDGNSGLMAKKQKRTPKRTSAAAKNEKNGTGQSSDSEDLPVLD 1118
+ES + G R +S ++ + +P + + + + +S DS+
Sbjct: 1674 KESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSK------ 1727
Query: 1119 NSSKCTPVKHLNVSKPQKLARSPARISPHIKDGEKDKHREK 1159
K K K K + A ++ +K KH++K
Sbjct: 1728 KKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKK 1768
Score = 52.4 bits (124), Expect = 3e-06
Identities = 117/533 (21%), Positives = 200/533 (37%), Gaps = 92/533 (17%)
Query: 415 PKVKEEKKDLEESMEEALKLDQEM-----PLTEVK--SEPEENIDSNSESEREEIELKSP 467
P+ K +K D E S EE +K Q + P + +K S NI E E E E
Sbjct: 1317 PQSKWDKDDFE-SEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSE---- 1371
Query: 468 RGRRRIARDVNSIKKEI-EEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPK 526
+I + + EI + E K + + K D DY EK+ E RKN+
Sbjct: 1372 ----KIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPE---KRKNS-T 1423
Query: 527 QKEKKIKKQEDSDKDSDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVKYGRG 586
Q EK+ +++ + + +S + T K DS +D P
Sbjct: 1424 QPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTP-------------- 1469
Query: 587 KTQKIYEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAK 646
K T+ D E Y + R DE + R +K + K
Sbjct: 1470 -------NRDKKTDYDTRE-------YSSSKRRDEKNELTR----------RKDSPSRNK 1505
Query: 647 NKEDSEKDEKRDEERQKSKRGRPPLKSTLSSNMPYGLSKTANSEGKSDSCSSDSETEDAL 706
+ +K++ R EER K+G K + SS P K + + D+ + ET+ ++
Sbjct: 1506 DSASGQKNKPR-EERDLPKKGTGDSKKSNSS--PSRDRKPHDHKATYDTKRPNEETK-SV 1561
Query: 707 EKNLINEE----LSLKDELEKNEN-----LNDDKLDEENPKISAHILKENDRTQMQPLET 757
+KN + L ++ E + N LN + E +I+ I K + + Q +
Sbjct: 1562 DKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHS 1621
Query: 758 LKL-------------EVGENEQIVQIFGNKMEKTEEVKKEAEKSPKGKGRRSKTKDLSL 804
+L E NE + N K EE K K K + L
Sbjct: 1622 SRLSSDLTRETDEAAFEPDYNESDSE--SNVSVKEEESSGNISKDLKDKIVEKAKESLDT 1679
Query: 805 EIIKISSFGQNEAGSEPHI---EAHSLELSSLDNKNFSSATEDEIDQCVKEKKLKRKILG 861
+ +N++ S P + +HS S + + S+++ + D K+KK ++K
Sbjct: 1680 AAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHK 1739
Query: 862 QSSPEKKIRIENGMEMTNTVSQERTSDCIGSEGMKNLNFEQHFERENEGMPSL 914
+ KK + G E+ SQ+ + KN + E+ E++++ + S+
Sbjct: 1740 KHKKHKKHKKHAGTEVELEKSQKHKHK--KKKSKKNKDKEKEKEKDDQKVKSV 1790
Score = 52.0 bits (123), Expect = 4e-06
Identities = 131/695 (18%), Positives = 250/695 (35%), Gaps = 100/695 (14%)
Query: 529 EKKIKKQEDSDKDSDEEEEKSQEREETESKCDS--------EGEEDEEDMEPCLTGTKVK 580
EK + + KD+ + +EK E + K + +GEE E + P L T K
Sbjct: 900 EKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRK 959
Query: 581 VKYGRGKTQKIYEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKK 640
+ G + ++ DD + ++ + + D+ ++ PK K
Sbjct: 960 SREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDK----RERDKPKAK 1015
Query: 641 -QKKKAKN-------KEDSEK-----DEKRDEERQKSKRGRPPLKSTLSSNMPYGLSKTA 687
K K KN KE+ K EK D ER++S R PP+K +K++
Sbjct: 1016 GDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSS 1075
Query: 688 NSEGK------------SDSCSSDSETEDALE--------KNLINEELSLKDELEKNENL 727
+S K S S ET+ E K++ +E+L+ K+E K N
Sbjct: 1076 SSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNE 1135
Query: 728 NDDKLDEENPKISAHILK-------ENDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTE 780
+ LD + K + E+ ++ LE ++ ++ ++ KM++T
Sbjct: 1136 KNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTP 1195
Query: 781 EVKKEAEKSPKGKGRRSKTKDLSLEIIKISSFGQNEAGSEPHIEAHSLELSSLDNKNFSS 840
E K + +P K IK++ + GS +I L+
Sbjct: 1196 EKDKISLSAPAKK-------------IKLNRETGKKIGSTENISNTKEPSEKLE------ 1236
Query: 841 ATEDEIDQCVKEKKLKRKILGQSSPEKKIRIENGMEMTNTVSQERTSDCIGSEGMKNLNF 900
+T ++ Q + K++RK+ G + ++ + S R S+ +
Sbjct: 1237 STSSKVKQEKVKGKVRRKVTGTEGSSSTL-VDYTSTSSTGGSPVRKSEEKTDTKRTVIKT 1295
Query: 901 EQHFERENEGMPSLIAESNQCIQQLTSERFDSPAEETVNIPLKEDEDAMPLIGPETLVCH 960
+ + +N + AE + Q+ ++D E+ +K + + P +++
Sbjct: 1296 MEEYNNDN----TAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVI-- 1349
Query: 961 EVDLDDLDEKDKTSIEDVAVESSESNSLVSIPPALP-PVVQHNFSVASPLTLSQDESRSV 1019
++ K ++ ES S + + ++QH V S + E
Sbjct: 1350 ----KNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQH--EVKSSKNSASSEKGKT 1403
Query: 1020 KSESDITIEVDSIAEESQEGLCERESANGFETNVASGTCSIIVQERESR--EKGQKRPSD 1077
K +E ++ + E+ES N N S+ +E+R +K +
Sbjct: 1404 KDRDYSVLEKENPEKRKNSTQPEKES-NLDRLNEQGNFKSLSQSSKEARTSDKHDSTRAS 1462
Query: 1078 GNSGLMAKKQKRTPKRT----SAAAKNEKNGTGQSSDSEDLPVLDNSSKCTPVKHLNVSK 1133
N + K+T T S+ ++EKN + DS N + K +K
Sbjct: 1463 SNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPS----RNKDSASGQK----NK 1514
Query: 1134 PQKLARSPARISPHIKDGEKDKHREKHPNSSPRTY 1168
P++ P + + K R++ P+ TY
Sbjct: 1515 PREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATY 1549
>gi|40068464 AT rich interactive domain 1B (SWI1-like) isoform 2 [Homo
sapiens]
Length = 2191
Score = 67.4 bits (163), Expect = 8e-11
Identities = 44/149 (29%), Positives = 79/149 (53%), Gaps = 6/149 (4%)
Query: 251 ASIFLKTRVVPDNWKMDISEILESSSSDDEDGPAEENDEEKEKEAKKTEEEVPEE-ELDP 309
AS+ L + P K+ + + +E P E+ +K + T E++ + EL
Sbjct: 951 ASVGLADMMSPGESKLPLPL---KADGKEEGTPQPESKSKKSSSSTTTGEKITKVYELGN 1007
Query: 310 E-ERDNFLQQLYKFMEDRGTPINKPPVLGYKDLNLFKLFRLVYHQGGCDNIDSGAVWKQI 368
E ER ++ + FME+RG+P++ P +G K L+LF+L+ V GG ++ W+++
Sbjct: 1008 EPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWREL 1067
Query: 369 YMDLGIPILNSAASYNVKTAYRKYLYGFE 397
+L + +SAAS ++K Y +YL+ FE
Sbjct: 1068 ATNLNVGTSSSAAS-SLKKQYIQYLFAFE 1095
Score = 30.8 bits (68), Expect = 8.5
Identities = 26/96 (27%), Positives = 45/96 (46%), Gaps = 23/96 (23%)
Query: 265 KMDISEILESSSSDDEDGPAEENDEE----KEKEAKKTEEE--------VPEEELDPEER 312
K D + + S ++ED ++DEE +E++++KTE + P+ DP+E+
Sbjct: 1660 KDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEK 1719
Query: 313 DNFLQQLYKFMEDRGTPINKPPVLGYKDLNLFKLFR 348
+Q KF +K P+ K NLF + R
Sbjct: 1720 P---KQASKF--------DKLPIKIVKKNNLFVVDR 1744
>gi|40068462 AT rich interactive domain 1B (SWI1-like) isoform 3 [Homo
sapiens]
Length = 2178
Score = 67.4 bits (163), Expect = 8e-11
Identities = 44/149 (29%), Positives = 79/149 (53%), Gaps = 6/149 (4%)
Query: 251 ASIFLKTRVVPDNWKMDISEILESSSSDDEDGPAEENDEEKEKEAKKTEEEVPEE-ELDP 309
AS+ L + P K+ + + +E P E+ +K + T E++ + EL
Sbjct: 938 ASVGLADMMSPGESKLPLPL---KADGKEEGTPQPESKSKKSSSSTTTGEKITKVYELGN 994
Query: 310 E-ERDNFLQQLYKFMEDRGTPINKPPVLGYKDLNLFKLFRLVYHQGGCDNIDSGAVWKQI 368
E ER ++ + FME+RG+P++ P +G K L+LF+L+ V GG ++ W+++
Sbjct: 995 EPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWREL 1054
Query: 369 YMDLGIPILNSAASYNVKTAYRKYLYGFE 397
+L + +SAAS ++K Y +YL+ FE
Sbjct: 1055 ATNLNVGTSSSAAS-SLKKQYIQYLFAFE 1082
Score = 30.8 bits (68), Expect = 8.5
Identities = 26/96 (27%), Positives = 45/96 (46%), Gaps = 23/96 (23%)
Query: 265 KMDISEILESSSSDDEDGPAEENDEE----KEKEAKKTEEE--------VPEEELDPEER 312
K D + + S ++ED ++DEE +E++++KTE + P+ DP+E+
Sbjct: 1647 KDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEK 1706
Query: 313 DNFLQQLYKFMEDRGTPINKPPVLGYKDLNLFKLFR 348
+Q KF +K P+ K NLF + R
Sbjct: 1707 P---KQASKF--------DKLPIKIVKKNNLFVVDR 1731
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 67.0 bits (162), Expect = 1e-10
Identities = 165/890 (18%), Positives = 348/890 (39%), Gaps = 150/890 (16%)
Query: 416 KVKEEKKDLEESMEEALKLDQEMPLTEV--KSEPEENIDSNSESEREEIELKSPRGRRRI 473
K++ +++LEE E+ L QE+ E+ K +EN++ S++ + R
Sbjct: 259 KIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREK 318
Query: 474 ARDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKKIK 533
A V+ ++ E+ K ++L D + V++ K++N++LL K + + + +
Sbjct: 319 AVRVDKLESEVSRYK--ERLHDIEFYKARVEE-----LKEDNQVLLETKTMLEDQLEGTR 371
Query: 534 KQEDSDKDSDEEEEKSQER-EETESKCDSEGEEDEEDMEPCLTGTKVKVKYGR------- 585
+ D + ++E + + + + E + D + ++ EE ME +T ++ K
Sbjct: 372 ARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMT-LEMAQKQSMDESLHLG 430
Query: 586 ------GKTQKIYEASIKST--EIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGP 637
+T ++ EA KS E+++ L+ N + V+ R +G
Sbjct: 431 WELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNA 490
Query: 638 KKKQKKKAKNKEDSEKDEKRDEERQKSKRGRPPLKSTLSSNMPYGLSKTANSEGKSDSCS 697
K K + +N+ S+K E + E + K+ ++ LSK D
Sbjct: 491 SKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQN---------LSK--------DLMK 533
Query: 698 SDSETEDALEKNLINEELSLKDELEKNENLNDDKLD-EENPKISAH-----------ILK 745
++ E +E N E +K ++NE+LN + +ISA IL
Sbjct: 534 EKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILH 593
Query: 746 ENDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTEEVKKEAEKSPK-GKGRRSKTKDLSL 804
E+ + L ++ E + ++ ++ + K E+ EE++ E K + + K +L +
Sbjct: 594 ESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKI 653
Query: 805 EIIKISSFGQNEAGSEPH-----------------IEAHSLELSSLDNKNFSSATEDEID 847
KI + Q + E +E+ E S LD +N E
Sbjct: 654 TCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESL 713
Query: 848 QCVKEKKLKRKILGQSSPEKKIRIENGMEMTNTVSQERTSDCIGSEGMKNLNFEQHFERE 907
+C K + ++ + +K +++ G+E+ ++ + +G+ + E
Sbjct: 714 KCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGL---------DIE 764
Query: 908 NEGMPSLIAESNQCIQQLTSERFDSPAEETVNIPLKEDEDAMPLIGPETLVCHEVDLDDL 967
N+ + + SN+ IQQL SE D E N L+++ + + + L+ L
Sbjct: 765 NQRLQKTLENSNKKIQQLESELQDLEME---NQTLQKNLEELKISSKR--------LEQL 813
Query: 968 DEKDKTSIEDVAVESSESNSLVSIPPALPPVVQHNFSVASPLTLSQDESRSVKSESDITI 1027
++++K+ ++ + + L + E++ ++ +++I
Sbjct: 814 EKENKSLEQETSQLEKDKKQL------------------------EKENKRLRQQAEIK- 848
Query: 1028 EVDSIAEESQEGLCERESANGFETNVASGTCSIIVQERESREKGQKRPSDGNSGLMAKKQ 1087
D+ EE+ + E N + S+E G + S + K+
Sbjct: 849 --DTTLEENNVKIGNLEKEN----------------KTLSKEIGIYKESCVRLKELEKEN 890
Query: 1088 KRTPKRTSAAAKNEKNGTGQSSDSEDLPVLDNSSKCTPVKHLNVSKPQKLARSPARISPH 1147
K KR + K + SE L ++ + H + +K+ + R+ H
Sbjct: 891 KELVKRATIDIKTLVT-LREDLVSEKLKTQQMNNDLEKLTH----ELEKIGLNKERLL-H 944
Query: 1148 IKDGEKDKHREKHPNSSPRTYKWSFQLNELDNMNSTERISFLQEKLQEIRKYYMSLKSEV 1207
+ D+++ + T K S ++ E E+I+ L+ +L+E Y L+ E+
Sbjct: 945 DEQSTDDRYKLLE-SKLESTLKKSLEIKE-------EKIAALEARLEESTNYNQQLRQEL 996
Query: 1208 ATIDRRRKRLKKKDREVSHAGASMSSASSDTGMSPSSSSPPQNVLAVECR 1257
T+ + + LK++ E +S + D S + +L V+ R
Sbjct: 997 KTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDR 1046
Score = 50.8 bits (120), Expect = 8e-06
Identities = 131/696 (18%), Positives = 286/696 (41%), Gaps = 74/696 (10%)
Query: 414 EPKVKEEKKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPRGRRRI 473
E ++ +EK+ L+ + L +E K++ E+ I++ E+ +I++ +
Sbjct: 511 ENEIVQEKQSLQNCQNLSKDLMKE------KAQLEKTIETLRENSERQIKILEQENEH-L 563
Query: 474 ARDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKKIK 533
+ V+S+++ + E ++KD + ENK + + + K +++ ++ K+ E +
Sbjct: 564 NQTVSSLRQR-SQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKE 622
Query: 534 KQEDSDKDSDEEEEKSQEREETESK-------CDSEGEEDEEDMEPCLTGTKVKVKYGRG 586
K E +++ +E +E E + K C+ ++E+ E K+K
Sbjct: 623 KGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSF 682
Query: 587 K--TQKIYEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKK 644
K T ++ +++++D+ E L L NV + L+ + ++++
Sbjct: 683 KNLTFQLESLEKENSQLDE-ENLELRR----NVESLKCASMKMAQLQLENKELESEKEQL 737
Query: 645 AKNKEDSEKDEKRDEERQKSKRGRPPLKSTLSSNMPYGLSKTANSEGKSDSCSSDSETED 704
K E + K+ E + S +G L + K E + +++T
Sbjct: 738 KKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQT-- 795
Query: 705 ALEKNLINEELSLK--DELEKNENLNDDKLDEENPKISAHILKENDRTQMQ------PLE 756
L+KNL ++S K ++LEK EN + ++ + K + KEN R + Q LE
Sbjct: 796 -LQKNLEELKISSKRLEQLEK-ENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLE 853
Query: 757 TLKLEVG----ENEQI---VQIFGNKMEKTEEVKKEAEKSPKGKGRRSKT-----KDLSL 804
+++G EN+ + + I+ + +E++KE ++ K KT +DL
Sbjct: 854 ENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVS 913
Query: 805 EIIKISSFGQNEAGSEPHIEAHSLELSSLDNKNFSSATEDEIDQCVKEKKLKRKILGQSS 864
E +K + +E L L + S+ ++ + E LK+ + +
Sbjct: 914 EKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSL--EIK 971
Query: 865 PEKKIRIENGM-EMTNTVSQERTSDCIGSEGMKNLNFEQHFERENEGMPSLIAESNQCIQ 923
EK +E + E TN Q R + + L Q ER + P + E N
Sbjct: 972 EEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDN---- 1027
Query: 924 QLTSERFDSPAEETVNIPLKEDEDAMPLIGPETLVCHEVDLDDLDEKDKTSIEDVAVESS 983
+++ ++ET LK + LI E + L + KT ++ + +++
Sbjct: 1028 -----KWERESQETTRELLKVKD---RLIEVER---NNATLQAEKQALKTQLKQLETQNN 1076
Query: 984 ESNS-LVSIPPALPPVVQHNFSVASPLTLSQDESRSVKSES--------DITIEVDSIAE 1034
+ ++++ + + N ++ + Q E+ ++ S+S + I+ S+
Sbjct: 1077 NLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLEN 1136
Query: 1035 ESQEGLCERESANG-FETNVASGTCSIIVQERESRE 1069
E++ + ERE +++ + ++ ER++ E
Sbjct: 1137 ENESVIKEREDLKSLYDSLIKDHEKLELLHERQASE 1172
Score = 49.7 bits (117), Expect = 2e-05
Identities = 122/569 (21%), Positives = 226/569 (39%), Gaps = 49/569 (8%)
Query: 704 DALEKNLINEELSLKDELEK-NENLNDD-KLDEENPKISAHILKENDRTQMQPLETLKLE 761
D + N + +++ K E ++ N+ +N+D L N I +K + +Q L + L
Sbjct: 44 DGVFLNQVMLQINPKLESQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLP 103
Query: 762 VGENEQIVQIFGNKMEKTEEVKKEAEKSPKGKGRRSKTKDLSLEIIKISSFGQNEAGSEP 821
N I+ + TEEVKK G + + K+ +E I+ F +A
Sbjct: 104 ---NVLIIGKNPFSEQGTEEVKKLLLLL-LGCAVQCQKKEEFIERIQGLDF-DTKAAVAA 158
Query: 822 HIE--AHSLE-LSSLDNKNFSSATEDEIDQCVKEKKLKRKILGQSSPEKKIRI------E 872
HI+ H+ E + L + ++++I+ +K L K L E I
Sbjct: 159 HIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEER 218
Query: 873 NGMEMTNTVSQERTSDCIGSEGMKNLNFEQHFERENEGMPSLIAESNQCIQQLTSERFDS 932
+G+ S S C GS GMK QH E + I Q +++ T + D
Sbjct: 219 DGLHFLPHASSSAQSPC-GSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDC 277
Query: 933 PAE-ETVNIPLK--EDEDAMPLIGPETLVCHEVDLDDLDEK----DKTSIEDVAVESSES 985
E E + I LK + E+ L + + +LD L EK DK E V+
Sbjct: 278 KQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESE-VSRYKERL 336
Query: 986 NSLVSIPPALPPVVQHNFSVASPLTLSQDESRSVKSESDITIEVDSIAEESQEGLCERES 1045
+ + + + + N + T+ +D+ ++ SD E++ + + L + E
Sbjct: 337 HDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDME- 395
Query: 1046 ANGFETNVASGTCSIIVQERESREKGQKRPSDG--NSGLMAKKQKRTPKRTSAAAKNEKN 1103
E ++ +++E + E QK+ D + G ++ RT + + A K+ +
Sbjct: 396 ---MERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGH 452
Query: 1104 GTGQSSDSEDLPV-LDNSSKCTPVKHL---------NVSKPQKLARSPARISPHIKDGEK 1153
+ + S L + ++N S V+ L N SK K+ + R+S ++ E
Sbjct: 453 EVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILEN 512
Query: 1154 DKHREKH-----PNSSPRTYKWSFQLN---ELDNMNSTERISFLQEKLQEIRKYYMSLKS 1205
+ +EK N S K QL E NS +I L+++ + + + SL+
Sbjct: 513 EIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQ 572
Query: 1206 EVATIDRRRKRLKKKDREVSHAGASMSSA 1234
R + +K+ ++ H +S+
Sbjct: 573 RSQISAEARVKDIEKENKILHESIKETSS 601
Score = 40.4 bits (93), Expect = 0.011
Identities = 145/756 (19%), Positives = 287/756 (37%), Gaps = 105/756 (13%)
Query: 512 KKENELLLGRKNTPKQKEKKIKKQEDSDKDSDE------EEEKSQEREETESKCDSEGEE 565
KK LLLG ++KE+ I++ + D D+ +E + + + +
Sbjct: 122 KKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDM 181
Query: 566 DEEDMEPCLTGTKVKVKYGRGKTQKIYEASIKSTEIDDGEVLYLVHYYGWNVRY---DEW 622
+ED+EP L + +K + + E I+ +E DG L+ + + + +
Sbjct: 182 SQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDG--LHFLPHASSSAQSPCGSPG 239
Query: 623 VKADRIIWPLDKGGPKKKQKKKAKNKEDSEKDEKRDEERQKSKRGRPPLKSTLSSNMPYG 682
+K L K K + +E EK E+ + +Q+ ++ LK NM
Sbjct: 240 MKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENM--- 296
Query: 683 LSKTANSEGKSDSCSSDSETEDALEKNLINEELSLKDELEKNENLNDDKL-DEENPKISA 741
S+ +S D E + + E+ D+LE + ++L D E K
Sbjct: 297 ---NLLSDARSARMYRD-------ELDALREKAVRVDKLESEVSRYKERLHDIEFYKARV 346
Query: 742 HILKENDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTEEVKKEAEKSPKGKGRRSKTKD 801
LKE+++ ++ L+ ++ + +K E++KE + K K
Sbjct: 347 EELKEDNQVLLETKTMLEDQLEGTRA-------RSDKLHELEKE--------NLQLKAKL 391
Query: 802 LSLEIIKISSFGQNEAGSEPHIEAHSLELSSLDNKNFSSATEDEIDQCVKEKKLKRKILG 861
+E+ + + E E ++ + S+D ++I + + + +K LG
Sbjct: 392 HDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLG 451
Query: 862 Q------SSPEKKIRIENGMEMTNTVSQERTS-DCIGSEGMKNLNFE---QHFERENEGM 911
SS K+ +EN +T TV + RT+ D + K L E Q ++ E +
Sbjct: 452 HEVNELTSSRLLKLEMEN-QSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEIL 510
Query: 912 PSLIAESNQCIQQLTSERFD-----SPAEETVNIPLKEDEDAMPLIGPETLVCHEVDLDD 966
+ I + Q +Q + D + E+T+ + E + ++ E ++ +
Sbjct: 511 ENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQT-VSS 569
Query: 967 LDEKDKTSIEDVAVESSESNSLVSIPPALPPVVQHNFSVASPLTLSQDESRSVKSESDIT 1026
L ++ + S E + + N ++ + +S L+ + E R +K E +
Sbjct: 570 LRQRSQISAEARVKDIEKENKILH---------ESIKETSSKLSKIEFEKRQIKKELEHY 620
Query: 1027 IEVDSIAEESQEGLCERESANGFE----TNVASGTCSIIVQERESREKGQKRPSDGNSGL 1082
E AEE + L E N TN+ I E+E+ E
Sbjct: 621 KEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSE------------- 667
Query: 1083 MAKKQKRTPKRTSAAAKN--------EKNGTGQSSDSEDLPVLDNSSKCTPVKHLNVSKP 1134
+++ R K+T + KN EK + ++ +L S KC +K +
Sbjct: 668 -LERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLE 726
Query: 1135 QKLARSPARISPHIKDGEKDKHREKHPNSSPRTYKWSFQLNELDNM-------NSTERIS 1187
K S + +K K + S+Q +++N NS ++I
Sbjct: 727 NKELESEK------EQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ 780
Query: 1188 FLQEKLQEIRKYYMSLKSEVATIDRRRKRLKKKDRE 1223
L+ +LQ++ +L+ + + KRL++ ++E
Sbjct: 781 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKE 816
Score = 33.9 bits (76), Expect = 1.0
Identities = 98/538 (18%), Positives = 192/538 (35%), Gaps = 66/538 (12%)
Query: 289 EEKEKEAKKTEEEVPEEELDPEERDNFLQQLYKFMEDRGTPI--NKPPVLGYKDLNLFKL 346
E+ EKE K E+E + E D ++ + ++L + E + T + N + + N
Sbjct: 811 EQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLS 870
Query: 347 FRLVYHQGGCDNI-----DSGAVWKQIYMDLG--IPILNSAASYNVKT-AYRKYLYGFEE 398
+ ++ C + ++ + K+ +D+ + + S +KT L
Sbjct: 871 KEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTH 930
Query: 399 YCRSANIQFRTVHHHEPKVKEEKKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESE 458
+ + H E + K LE +E LK E+ ++ + +S + ++
Sbjct: 931 ELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQ 990
Query: 459 REEIELKSPRGRRRIARDVNSIKKEIEEEKTEDKL-----KDNDTENKDVDDDYETAEKK 513
+ ELK+ + ++ ++K+ +EE+ +DN E + + E + K
Sbjct: 991 QLRQELKT------VKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVK 1044
Query: 514 ENELLLGRKNTPKQKEKKIKKQEDSDKDSDEEEEKSQ-----------EREETESKCDSE 562
+ + + R N Q EK+ K + ++ ++Q + + T + +
Sbjct: 1045 DRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNA 1104
Query: 563 GEEDE----EDMEPCLTGTKVKVKYGRGKTQKIYEASIKSTE---------IDDGEVLYL 609
+ E L ++ + + E+ IK E I D E L L
Sbjct: 1105 KLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLEL 1164
Query: 610 VHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDSEKD-EKRDEERQKSKRGR 668
+H +A + K G K KN E +D E R + K K
Sbjct: 1165 LHER----------QASEYESLISKHGTLKSAH---KNLEVEHRDLEDRYNQLLKQKGQL 1211
Query: 669 PPLKSTLSSNMPYGLSKTANSEGKSDS----CSSDSETEDALEKNLINEELSLKDELEKN 724
L+ L L + N E + C + + L E+ D
Sbjct: 1212 EDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLK 1271
Query: 725 ENLNDDKLDEENPKISAHILKENDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTEEV 782
LN+ KL E ++ A K ++ Q + + KL + E + Q+ GN E+ +
Sbjct: 1272 SLLNNSKL--EQTRLEAEFSKLKEQYQQLDITSTKLN-NQCELLSQLKGNLEEENRHL 1326
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 67.0 bits (162), Expect = 1e-10
Identities = 203/1086 (18%), Positives = 429/1086 (39%), Gaps = 210/1086 (19%)
Query: 229 IKEVDILNLP-ESELSTKPGL--------QKASIFLKTRVVPDNWKMDISEILESSSSDD 279
+K ++ N E+ELS+K L +K ++ ++ + +N KMD+S LES
Sbjct: 563 VKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKL-ENIKMDLSYSLESIEDPK 621
Query: 280 EDGPAEENDEEKEKEAKKTEEEVPEEELDPEERDNFLQQLYKFMEDRGTPINKPPVLGYK 339
+ + E +AK+ + E L+ +E+ L YK ME+
Sbjct: 622 QMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMEN-------------- 667
Query: 340 DLNLFKLFRLVYHQGGCDNIDSGAVWKQIYMDLGIPILNSAASYNVKTAYRKYLYGFEEY 399
D+ L++ K++ +DL + +++N T + G
Sbjct: 668 DIQLYQ--------------SQLEAKKKMQVDLEKEL---QSAFNEITKLTSLIDGKVPK 710
Query: 400 CRSANIQFRTVHHHEPKVKEEKKDLEESMEEALKLDQEMPL-TEVKSEPEE--NIDSNSE 456
N++ E K+ + +K+L + +EE L +E+ L +E+KS P E + +
Sbjct: 711 DLLCNLEL------EGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQ 764
Query: 457 SEREEIELKSPRGRRRIARDVNS---IKKEIEE-EKTEDKLKDNDTENKDVDDDYETAE- 511
+ EE+ + + + + V+ ++ +EE KT+D L + K D +++ +
Sbjct: 765 DKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKT 824
Query: 512 -----KKENELLLGRKNTPKQKEKKIKKQEDSDKDS------------DEEEEKSQEREE 554
+++ +++L Q+ + K+ S E +EK++E +E
Sbjct: 825 LHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQE 884
Query: 555 TESKCDSEGEEDEEDMEPCLTGTKVKVKYGRGKTQKIYEASIKSTEIDDGEVLYLVHYYG 614
++ + E+ E T + K Q + E + E DD + L
Sbjct: 885 RLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQL------- 937
Query: 615 WNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDSEKDEKRD--EERQKSKRGRPPLK 672
E ++ +R K N +++ R+ E ++ + LK
Sbjct: 938 -----QESLQIER--------DQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLK 984
Query: 673 STLSSNMPYGLSKTANSEGKSDSCSSDSETEDALEKNLIN----EELSLKDELEKNENLN 728
S +S + L N+ ET+D ++ ++ ++L K+ ++
Sbjct: 985 SKISEEVSRNLHMEENT----------GETKDEFQQKMVGIDKKQDLEAKNTQTLTADVK 1034
Query: 729 DDKLDEENPKISAHILKENDRTQM-----QPLETLKLEVGEN-------EQIVQIFGNKM 776
D+++ E+ KI + I ++N+ QM E LK ++ EN ++ +++ G+++
Sbjct: 1035 DNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDEL 1094
Query: 777 EKTEEV---------KKEAEKSP------------KGKGRRSKTKDLSL----------- 804
+K +E+ KKE E S K K ++ + K L
Sbjct: 1095 KKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQ 1154
Query: 805 ----EIIKISSFGQNEAGSEPHIEAHSLELSSLDNKNFSSATEDEIDQCVKEKKLKRKIL 860
EI + + +N+ + H+E LEL+ N+N+ +E+ KE+K+ +++
Sbjct: 1155 KKINEIENLKNELKNKELTLEHMETERLELAQKLNENY-----EEVKSITKERKVLKEL- 1208
Query: 861 GQSSPEKKIRIENG----MEMTNTVSQERTSDCIGSEGMKNLNFEQHFERENEGMPSLIA 916
Q S E + G +E T ++E + +++ ++H E +E S+
Sbjct: 1209 -QKSFETERDHLRGYIREIEATGLQTKEELK-------IAHIHLKEHQETIDELRRSVSE 1260
Query: 917 ESNQCIQQLTSERFDSPAEETVNIPLKEDEDAMPLI-----GPETLVCHEVDLDDLDEKD 971
++ Q I E+ + +E + + L E+++ +P + ET+ E+ + KD
Sbjct: 1261 KTAQIINTQDLEKSHTKLQEEIPV-LHEEQELLPNVKEVSETQETMNELELLTEQSTTKD 1319
Query: 972 KTSIEDVAVESSESNSLVSIPPALPPVVQHNFSVASPLTLSQDESRSVKSESDITIEVDS 1031
T++ + +E N Q + LT +D +++K + ++ D
Sbjct: 1320 STTLARIEMERLRLNE----------KFQESQEEIKSLTKERDNLKTIKEA--LEVKHDQ 1367
Query: 1032 IAEESQEGLCE-RESANGFETNV----ASGTCSIIVQERES---REKGQKRPSDGNSGLM 1083
+ E +E L + +ES + E ++ + IV E E ++ R GL
Sbjct: 1368 LKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLS 1427
Query: 1084 AKKQKRTPKRTSAAAKNEKNGTGQSSDSEDLPVLDNSSKCTPVKHLNVSKPQKLAR---- 1139
+ Q+ + S A + + Q + L + K KHL + K+A
Sbjct: 1428 KRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLK 1487
Query: 1140 ------SPARISPHIKDGEKDKHREKHPNSSPRTYKWSFQLNELDNMNSTERISFLQEKL 1193
+ R++ K+ E +++ + + ++ E + + ++IS +QEK+
Sbjct: 1488 EQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKV 1547
Query: 1194 QEIRKY 1199
E++++
Sbjct: 1548 NELKQF 1553
Score = 60.8 bits (146), Expect = 8e-09
Identities = 170/886 (19%), Positives = 350/886 (39%), Gaps = 130/886 (14%)
Query: 414 EPKVKEEKKDLEESMEEALKLDQEMPLTEVKSEPEENIDS----------NSESEREEI- 462
E K+KE+ + L+E ++ L + +EM + K EN+ + + E+ER E+
Sbjct: 1126 EEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELA 1185
Query: 463 --------ELKSPRGRRRIARDVNSIKKEIEEEK----------------TEDKLKDNDT 498
E+KS R++ ++ ++K E E+ T+++LK
Sbjct: 1186 QKLNENYEEVKSITKERKVLKE---LQKSFETERDHLRGYIREIEATGLQTKEELKIAHI 1242
Query: 499 ENKDVDDDYETAEKKENELLLGRKNTPKQKEKKIKKQEDSDKDSDEEE-----EKSQERE 553
K+ + + + +E NT ++ K QE+ +E+E ++ E +
Sbjct: 1243 HLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQ 1302
Query: 554 ETESKCDSEGEEDEEDMEPCLTGTKVKVKYGRGKTQKIYEASIKSTEIDDGEVLYLVHYY 613
ET ++ + E+ L +++ K Q+ E IKS + + +
Sbjct: 1303 ETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQE-EIKSLTKERDNLKTIKE-- 1359
Query: 614 GWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDSEKDEKRDEERQKSKRGRPPLKS 673
V++D+ + I L K ++ Q K+ ++ EKD + + + ++ +P +
Sbjct: 1360 ALEVKHDQ--LKEHIRETLAK--IQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSA 1415
Query: 674 TLSSNMP-YGLSK-TANSEGKSDSCSSDSETEDALEKNLINEELSLKDELEKNENLNDDK 731
L + GLSK S + S + + + L++ L +E LK+ ++ E +
Sbjct: 1416 LLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIK--EIVAKHL 1473
Query: 732 LDEENPKISAHILKENDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTEEVKKEAEKSPK 791
EE K++ LKE + T + L++ + E E + ++E + + +
Sbjct: 1474 ETEEELKVAHCCLKEQEET----INELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIY 1529
Query: 792 GKGRRSKTKDLSLEIIKISSFGQ-NEAGSEPHIEAHSLELSSLDNKNFSSATEDEIDQCV 850
K + K +S K++ Q E S+E L+ N +++EI +
Sbjct: 1530 EKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMI 1589
Query: 851 KEKKLKRKILGQSSPEKKIRIENGMEMTNTV--SQERTSDCIGSEGM------------- 895
KEK+ +++ E+ EN E+ + SQE+ + +
Sbjct: 1590 KEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHL 1649
Query: 896 ------KNLNFEQHFERENEGMPSLIAESNQCIQQLTSERFD-SPAEETVNIPLKEDEDA 948
+ LN E + E EN + ++ E+ + ++ +T ER D EET LK + D
Sbjct: 1650 KEQFETQKLNLE-NIETENIRLTQILHENLEEMRSVTKERDDLRSVEET----LKVERDQ 1704
Query: 949 MPLIGPETLVCHEVDLDDLDEKDKTSIEDVAVESSESNSLVSIPPALPPVVQHNFSVASP 1008
+ ET+ DL+++++ I + ++ + L +V + S
Sbjct: 1705 LKENLRETIT------RDLEKQEELKIVHMHLKEHQETI-----DKLRGIVSEKTNEISN 1753
Query: 1009 LTLSQDESRSVKSESDITIEVD-SIA----EESQEGLCERESANGFETNVASGTCSIIVQ 1063
+ + S D+ I+ + IA +E QE + + I+ +
Sbjct: 1754 MQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLR--------------GIVSE 1799
Query: 1064 ERESREKGQKRPSDGNSGLMAKKQK-RTPKRTSAAAKNEKNGTGQS-SDSEDL--PVLDN 1119
+ + QK + N+ L K Q+ + + K + N T + S+ E L + D
Sbjct: 1800 KTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQ 1859
Query: 1120 SSKCTPVKHLNVSKPQKLARSPARISPHIKDGEKDKHREKHPNSSPRTYKWSFQLNELDN 1179
S + ++ N++ QKL + + +K+ + + E+ K S Q + +
Sbjct: 1860 SLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARD 1919
Query: 1180 MNSTERISFLQEKLQEIRKYYMSLKSEVATIDRRRKRLKKKDREVS 1225
+ E QE++ M K T+D+ R+++ +K ++S
Sbjct: 1920 L----------EIQQELKTARMLSKEHKETVDKLREKISEKTIQIS 1955
>gi|87299628 biorientation of chromosomes in cell division 1-like
[Homo sapiens]
Length = 3051
Score = 65.5 bits (158), Expect = 3e-10
Identities = 229/1141 (20%), Positives = 421/1141 (36%), Gaps = 204/1141 (17%)
Query: 150 VTEDEKEEESSEEEDEDKRRLN-------DELLGKVVSVVSATERTEWYPALVISPSCND 202
VT D EE +DE+K + N D GK SV A + + S S +D
Sbjct: 428 VTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDS-DD 486
Query: 203 DITV---------KKDQCLVRSFIDSKFYSIARKDIKEV-----------DILNLPESEL 242
++TV +K++ L+R I+ + RK E ++L ES
Sbjct: 487 ELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESST 546
Query: 243 -STKPGLQKASIFLKTRVVPDNWKMDISEILESSSSD-DEDGPAEENDEEKEKEAKKTEE 300
S +P + LK R V + K+ +S+ + S + +E+ ++ EE KE KT E
Sbjct: 547 KSLEPKAARIKEVLKERKVLEK-KVALSKKRKKDSRNVEENSKKKQQYEEDSKETLKTSE 605
Query: 301 EVPEEELDPEERDNFLQQLYKFMEDRGTPINKPPVLGYKDLNLFKLFRLVYHQGGCDNID 360
+E++ + K + + P +KP + L++ +N +
Sbjct: 606 HCEKEKISSSKE-------LKHVHAKSEP-SKPARRLSESLHVVD-----------ENKN 646
Query: 361 SGAVWKQIYMDLGIPILNSAASYNVKTAYRKYLYGFEEYCRSANIQFRTVHHHEPKVKEE 420
+ ++ P++ T K E C + ++ +E +K++
Sbjct: 647 ESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKD 706
Query: 421 KKD---LEESMEEALKLDQEMPLTEVKSEPEENIDSNSE-------SEREEIELKSPRGR 470
+ L+ +++ +K +E P E K+ E+ + + +E EL S
Sbjct: 707 DSETPHLKSLLKKEVKSSKEKPERE-KTPSEDKLSVKHKYKGDCMHKTGDETELHSSEKG 765
Query: 471 RRIARDVNSIKKEIE---EEKTEDKLKDNDTENKDV--DDDYETAE---------KKENE 516
++ ++ ++ + ++KTE K K + V D +E +KEN
Sbjct: 766 LKVEENIQKQSQQTKLSSDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKENN 825
Query: 517 LLLGRKNTPKQK-EKKIKKQEDSDKDSDEEEEKS-----QEREE--TESKCDSEGEEDEE 568
R + K K E K ++ DS D K Q R E +E KCD + +
Sbjct: 826 KKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDMDSTNMDS 885
Query: 569 DMEPCLTGTKVKVKYGRGKTQKIYEAS--IKSTEIDDGEVLYLVHYYGWNVRYDEWVKAD 626
+++P + V + +T+ + E +KS G+ + +V
Sbjct: 886 NLKP-----EEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVE--------------- 925
Query: 627 RIIWPLDKGGPK-----KKQKKKAKNKEDSEKDEK-RDEERQKSKRGRPPLKSTLSSNMP 680
L +G K K K+K + DSEK K + E++ + G P+ T SS+
Sbjct: 926 ---TELQEGATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASSS-A 981
Query: 681 YGLSK---------TANSEGKSDSCSSDSETEDALEKNLINEEL--SLKDELEKNENLND 729
+ K A + KSD S+ + E L + L S KD +K+EN +D
Sbjct: 982 HSTQKDSSHRAKLPLAKEKYKSDKDSTSTRLERKLSDGHKSRSLKHSSKDIKKKDENKSD 1041
Query: 730 DKLDEENPKISAHILKENDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTEE-VKKEAEK 788
DK +E S+H + + M+ + L + EN + +M K EE +
Sbjct: 1042 DKDGKEVD--SSHEKARGNSSLME--KKLSRRLCENRR--GSLSQEMAKGEEKLAANTLS 1095
Query: 789 SPKGKG--RRSKTKDLSLEIIKISSFGQNEAGSEPHIE----------------AHSLEL 830
+P G R K+ D++L I E SEP +E ++
Sbjct: 1096 TPSGSSLQRPKKSGDMTL----IPEQEPMEIDSEPGVENVFEVSKTQDNRNNNSQQDIDS 1151
Query: 831 SSLDNKNFSSATEDEIDQCVKEKKL-----------------KRKILGQSSPEKKIRIEN 873
++ K ++ +DE+ C + K ++ +S+ KK+ I++
Sbjct: 1152 ENMKQKTSATVQKDELRTCTADSKATAPAYKPGRGTGVNSNSEKHADHRSTLTKKMHIQS 1211
Query: 874 GMEMTNTVSQE-----RTSDCIGSEGMKN--LNFEQHFERENEGMPSLIAESNQCIQQLT 926
+ N +E T I SE + L+ +R + + + AE + T
Sbjct: 1212 AVSKMNPGEKEPIHRGTTEVNIDSETVHRMLLSAPSENDRVQKNLKNTAAEEHVAQGDAT 1271
Query: 927 SERF----DSPAEETVN-IPLKE--DEDAMPLIGPETLV------CHEVDLDDLDEKDKT 973
E SP+ +V +PL+E D D +PL T++ D L + T
Sbjct: 1272 LEHSTNLDSSPSLSSVTVVPLRESYDPDVIPLFDKRTVLEGSTASTSPADHSALPNQSLT 1331
Query: 974 SIEDVAVESSESNS-----LVSIPPALPPVVQHNFSVASPLTLSQDESRSV-----KSES 1023
E +++S+S V P + + A TL + V +
Sbjct: 1332 VRESEVLKTSDSKEGGEGFTVDTPAKASITSKRHIPEAHQATLLDGKQGKVIMPLGSKLT 1391
Query: 1024 DITIEVDSIAEE-SQEGLCERESANGFETNVASGTCSIIVQERESREKGQKRPSDGNSGL 1082
+ +E ++I +E + ++E+ E N+ T V+ + N+
Sbjct: 1392 GVIVENENITKEGGLVDMAKKENDLNAEPNLKQ-TIKATVENGKKDGIAVDHVVGLNTEK 1450
Query: 1083 MAKKQKRTPKRTSAAAKNEKNGTGQSSDSEDLPVLDNSSKCTPVKHLNVSKPQKLARSPA 1142
A+ K KR+ K+ + +++ ++ S V H + + +A P
Sbjct: 1451 YAETVKLKHKRSPGKVKDISIDVERRNENSEVDTSAGSGSAPSVLHQRNGQTEDVATGPR 1510
Query: 1143 R 1143
R
Sbjct: 1511 R 1511
Score = 62.8 bits (151), Expect = 2e-09
Identities = 153/836 (18%), Positives = 324/836 (38%), Gaps = 69/836 (8%)
Query: 426 ESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPRGRRRIAR--DVNSIKKE 483
++ E A K P T+ ++ E + ++ E+ + G + + + +
Sbjct: 228 KTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTAD-SGGEGLETAPKSEEFSDLPCP 286
Query: 484 IEEEKTEDKLKDN-DTENKDVDDDYETAEKKENELLLGRKNTPKQKEKKIKKQEDSDKDS 542
+EE K K +N NKDV + + K + + ++ ++ E+K +K+E ++K
Sbjct: 287 VEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKF 346
Query: 543 DEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVKYGRGKTQKIYEASIKSTEID 602
D ++ ++ + K E E + + K K G + + S+ +++D
Sbjct: 347 DHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKE-----DFSLIDSDVD 401
Query: 603 DGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDSEKDEKRDEERQ 662
+ + + ++ E + ++ + + KNK++ K + D
Sbjct: 402 GLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEG 461
Query: 663 KSKRGR------PPLKSTLSSNMPYGLSKTANSEGKSDSCSSDSETEDALEKNLINEELS 716
K+K R P L S S+ L+ + S E E+ L + IN E
Sbjct: 462 KTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQ------SIAKEKEERLLRRQINREKL 515
Query: 717 LKDELEKNENLNDDKLDEENPKISAHILKENDRTQMQPLETLKLEVGENEQIVQIFGNKM 776
+ +K E K + S+ L+E+ ++P EV + ++++ K+
Sbjct: 516 EEKRKQKAEKTKSSKTKGQGR--SSVDLEESSTKSLEPKAARIKEVLKERKVLE---KKV 570
Query: 777 EKTEEVKKEAEKSPKGKGRRSKTKDLSLEIIKISSFGQNE--AGSEPHIEAHSLELSSLD 834
+++ KK++ + ++ + ++ S E +K S + E + S+ H+ S
Sbjct: 571 ALSKKRKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELKHVHAKSEPSKP 630
Query: 835 NKNFSSATEDEIDQCVKEKKLKRKILGQSSPEKKIRIENGMEMTNTVSQER---TSDCIG 891
+ S + +D+ E KL+R+ ++S + +E E T+T +R S+
Sbjct: 631 ARRLSESLH-VVDENKNESKLEREHKRRTS--TPVIMEGVQEETDTRDVKRQVERSEICT 687
Query: 892 SEGMK---NLNFEQHFERENEGMPSL--IAESNQCIQQLTSERFDSPAEETVNIPLKEDE 946
E K L E+H ++++ P L + + + ER +P+E+ +++ K
Sbjct: 688 EEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTPSEDKLSVKHKYKG 747
Query: 947 DAMPLIGPETLVCH-------EVDLDDLDEKDKTSIEDVAVESSESNSLVSIPPALPPVV 999
D M G ET + E ++ ++ K S +D S+ + + V+
Sbjct: 748 DCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSKHRNERKL-----SVL 802
Query: 1000 QHNFSVASPLTLSQDESRSVKSESDITIEVDSIAEESQEGLCERESANGFE-TNVASGTC 1058
+ S + DE +V+ E++ S + E R S + + ++ S
Sbjct: 803 GKDGKPVSEYIIKTDE--NVRKENNKKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQH 860
Query: 1059 SIIVQERE---SREKGQKRPSDGNSGLMAKKQKRTPKRTSAAAKNEKNGTGQSSDSE--D 1113
I +Q R S +K ++ +S L ++ KR + + EK S ++
Sbjct: 861 GITLQRRSESYSEDKCDMDSTNMDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQ 920
Query: 1114 LPVLDNSSKCTPVKHLNVSKPQKLARSPARISPHIKDGEKDKHREKHPNSSP--RTYKWS 1171
+ V++ + K KP K + ++ + +K R+ P T
Sbjct: 921 VKVVETELQEGATKQATTPKPDK--------EKNTEENDSEKQRKSKVEDKPFEETGVEP 972
Query: 1172 FQLNELDNMNSTERISFLQEKLQEIRKYYMSLKSEVATIDRRRKRLKKKDREVSHA 1227
+ +ST++ S + KL ++ Y S K +T R+ K R + H+
Sbjct: 973 VLETASSSAHSTQKDSSHRAKLPLAKEKYKSDKDSTSTRLERKLSDGHKSRSLKHS 1028
Score = 47.4 bits (111), Expect = 9e-05
Identities = 58/272 (21%), Positives = 117/272 (43%), Gaps = 28/272 (10%)
Query: 417 VKEEKKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPRGRRRIARD 476
V+ + K++EE K ++ + EP++N D +S E + + P ++
Sbjct: 2754 VEADPKEVEEEERHMPKRKRKQHYLSSEDEPDDNPDV-LDSRIETAQRQCPETEPHDTKE 2812
Query: 477 VNSIKKEIEE-EKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKKIKKQ 535
NS +++EE KT + + + D+Y ++E G K P+Q + K
Sbjct: 2813 ENS--RDLEELPKTSSETNSTTSRVMEEKDEYSSSETT------GEK--PEQNDDDTIKS 2862
Query: 536 EDSDKDSDEEEEKSQERE---ET--ESKCDSEGEEDEEDMEPCLTGTKVKVKYGRGKTQK 590
++ D+ + ++ + R+ ET + K DS+ + +E + +K+KV ++
Sbjct: 2863 QEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKE 2922
Query: 591 IYEASIKSTEIDDGE--VLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKA--- 645
+S DDGE ++ V G + V D + P++K++K
Sbjct: 2923 TANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDA-----ESSEPERKRQKSVSDP 2977
Query: 646 -KNKEDSEKDEKRDEERQKSKRGRPPLKSTLS 676
++K++ E DE+ +EE + G +T S
Sbjct: 2978 VEDKKEQESDEEEEEEEEDEPSGATTRSTTRS 3009
Score = 45.1 bits (105), Expect = 4e-04
Identities = 80/398 (20%), Positives = 157/398 (39%), Gaps = 44/398 (11%)
Query: 224 IARKDIKEVDILNLPESELSTKPG----LQKASIFLKTRVVPDNWKMDISEILESSSSDD 279
+ ++ K +IL PES KP LQ+ + + + +N +E + S S +
Sbjct: 2676 VPSEEEKNGEILAPPESLCGGKPSGIAELQREPLLVNESLNVENSGFRTNEEIHSESYNK 2735
Query: 280 EDGPAEENDEEKEKEAKKTE---EEVPEEELDPEERDNFLQQLYKFMEDRGTPINKPPVL 336
+ + D + E +EV EEE +R +Q Y ED P + P VL
Sbjct: 2736 GEISSGRKDNAEAISGHSVEADPKEVEEEERHMPKRKR--KQHYLSSEDE--PDDNPDVL 2791
Query: 337 GYKDLNLFKLFRLVYHQGGCDNIDSGAVWKQIYMDLGIPILNSAASYNVKTAYRKYLYGF 396
R+ Q C + ++ DL + +++ N T+ + +
Sbjct: 2792 DS---------RIETAQRQCPETEPHDTKEENSRDLE-ELPKTSSETNSTTS--RVMEEK 2839
Query: 397 EEYCRSANIQFRTVHHHEPKVKEEKKDLEESMEEALKLDQEMPL-TEVKSEPEENIDSNS 455
+EY S + + + +K +++D ++ ++ P+ T +K + + D+
Sbjct: 2840 DEYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGI 2899
Query: 456 ESEREEIELKSPRGRRRIARDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKEN 515
+ + SP + + KE + E + ++D E K V K +
Sbjct: 2900 VTVEQ-----SPSSSKLKVMQTDESNKETANLQ-ERSISNDDGEEKIVTSVRRRGRKPKR 2953
Query: 516 ELLLG---RKNTPKQKEKKI-------KKQEDSDKDSDEEEEKSQEREETESKCDSEGEE 565
L + + P++K +K KK+++SD++ +EEEE T S SE +
Sbjct: 2954 SLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQR 3013
Query: 566 DEEDMEPCLTGTKVKVKYG---RGKTQKIYEASIKSTE 600
+ + P + + G RG+ Q++ EA +K +
Sbjct: 3014 SKTQLSPSIKRKREVSPPGARTRGQ-QRVEEAPVKKAK 3050
Score = 44.7 bits (104), Expect = 6e-04
Identities = 49/216 (22%), Positives = 82/216 (37%), Gaps = 12/216 (5%)
Query: 97 DERTLRRTSLCLKGERHFAESET---LDQLPLTNPEHFGTPVIAKKTNRGRRSSLPVTED 153
D R C + E H + E L++LP T+ E T T+R +
Sbjct: 2792 DSRIETAQRQCPETEPHDTKEENSRDLEELPKTSSETNST------TSRVMEEKDEYSSS 2845
Query: 154 EKEEESSEEEDEDKRRLNDELLGKVVSVVSATERTEWYPALVISPSCNDDITVKKDQCLV 213
E E E+ D+D + +E + + + R YP + + DD V
Sbjct: 2846 ETTGEKPEQNDDDTIKSQEE--DQPIIIKRKRGRPRKYP-VETTLKMKDDSKTDTGIVTV 2902
Query: 214 RSFIDSKFYSIARKDIKEVDILNLPESELSTKPGLQKASIFLKTRVVPDNWKMDISEILE 273
S + + D + NL E +S G +K ++ R + +S+ E
Sbjct: 2903 EQSPSSSKLKVMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAE 2962
Query: 274 SSSSDDEDGPAEENDEEKEKEAKKTEEEVPEEELDP 309
SS + + + + E +KE + EEE EEE +P
Sbjct: 2963 SSEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEP 2998
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 65.1 bits (157), Expect = 4e-10
Identities = 136/689 (19%), Positives = 250/689 (36%), Gaps = 134/689 (19%)
Query: 441 TEVKSEPEENIDSNSESEREEIELKSPRGRRRIARDVNSIKKEIEEEKTEDKLKDNDTEN 500
T +K + EE I +SE+E + +EE+ E ++ + TE
Sbjct: 434 THIKVKSEEKIKVVEKSEKETVI--------------------VEEQTEETQVTEEVTEE 473
Query: 501 KDVDDDYETAEKKENELLLGRKNTPKQKEKKIKKQEDSDKDSDEEEEKSQEREETESKCD 560
++ + E +++E G + + E++ K + S E+E KS +EE +S +
Sbjct: 474 EEKEAKEEEGKEEEG----GEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAE 529
Query: 561 SEGEEDEEDMEPCLTGTKVKVKYGRGKTQKIYEASIKSTEIDDGEVLYLVHYYGWNVRYD 620
++ E EE P + K K K + KS E ++ +
Sbjct: 530 AKSPEKEEAKSPAEVKSPEKAK-SPAKEEAKSPPEAKSPEKEEAKS-------------- 574
Query: 621 EWVKADRIIWPLDKGGPKKKQ---KKKAKNKEDSEKDEKR----DEERQKSKRGRPPLKS 673
P + P+K + K++AK+ +++ EK EE + + P+K
Sbjct: 575 ----------PAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKE 624
Query: 674 TLSS----NMPYGLSKTANSEGKSDSCSSDSETEDALEKNLINEELSLKDELEKNENLND 729
S P E KS + E E+A K+ + +K E + E
Sbjct: 625 EAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEA--KSPEKAKSPVKAEAKSPEKAKS 682
Query: 730 D-KLDEENPKISAHILKENDRTQMQPLETLKLEVGENEQI---VQIFGNKMEKTEEVKKE 785
K + ++P+ + +KE ++ + +K E E+ V+ EK + KE
Sbjct: 683 PVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKE 742
Query: 786 AEKSPKGKGRRSKTKDLSLEIIKISSFGQNEAGSEPHIEAHSLELSSLDNKNFSSATEDE 845
KSP+ K K L ++ + + + EA S F +
Sbjct: 743 EAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPA--------------DKFPEKAKSP 788
Query: 846 IDQCVKEKKLKRKILGQSSPEKKIRIENGMEMTNTVSQERTSDCIGSEGMKNLNFEQHFE 905
+ + VK + + L + + + I E+ + V +E E+ E
Sbjct: 789 VKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEE----------------EKPQE 832
Query: 906 RENEGMPSLIAESNQCIQQLTSERFDSPAEETVNIPLKEDEDAMPLIGPETLVCHEVDLD 965
+ + P E T E+ DS EE P KE P+ V E +
Sbjct: 833 VKVKEPPKKAEEEKAPATPKTEEKKDSKKEEA---PKKE--------APKPKV--EEKKE 879
Query: 966 DLDEKDKTSIEDVAVESSESNSLVSIPPALPPVVQHNFSVASPLTLSQDESRSVKSESDI 1025
EK K S + E +E V P P A P ++++ K E D
Sbjct: 880 PAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKP----KEKTEVAKKEPD- 934
Query: 1026 TIEVDSIAEESQEGLCERESANGFETNVASGTCSIIVQERESREKGQKRPSD-GNSGLMA 1084
D+ A+E + ++E+A ++++++E+ K+P + + A
Sbjct: 935 ----DAKAKEPSKPAEKKEAA---------------PEKKDTKEEKAKKPEEKPKTEAKA 975
Query: 1085 KKQKRTPKRTSAAAKNEKNGTGQSSDSED 1113
K+ +T + + K EK S+D +D
Sbjct: 976 KEDDKTLSKEPSKPKAEKAEKSSSTDQKD 1004
Score = 57.4 bits (137), Expect = 8e-08
Identities = 119/629 (18%), Positives = 245/629 (38%), Gaps = 63/629 (10%)
Query: 376 ILNSAASYNVK-TAYRKYLYGFEEYCRSANIQFRTVH----------HHEPKVKEEKKDL 424
+LN + +++ AYRK L G E I F H + K +E+ K +
Sbjct: 388 LLNVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVSTHIKVKSEEKIKVV 447
Query: 425 EESMEEALKLDQEMPLTEVKSE--------------PEENIDSNSESEREEIELKSPRGR 470
E+S +E + ++++ T+V E EE E+E E E KSP
Sbjct: 448 EKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAE 507
Query: 471 RRIARDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEK 530
+ + + EE K+ + K + E + ++ EK ++ K+ P+ K
Sbjct: 508 EAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSP 567
Query: 531 KIKKQEDSDKDSDEEEEKSQEREETESKCDSEGEE------DEEDMEPCLTGTKVKVKYG 584
+ ++ + + E+ KS +EE +S +++ E EE P + VK +
Sbjct: 568 EKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAK 627
Query: 585 RGKTQKIYEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKA---------DRIIWPLDKG 635
K E + T+ + + E K+ ++ P+ K
Sbjct: 628 SPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPV-KA 686
Query: 636 GPKKKQKKKAKNKEDSEKDEKR----DEERQKSKRGRPPLKSTLSSNMPYGLSKTANSEG 691
K +K K+ KE+++ EK EE + ++ + P+K + P E
Sbjct: 687 EAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKE--EAKTPEKAKSPVKEEA 744
Query: 692 KSDSCSSDSETEDALEKNLINEELSLKDELEKNENLNDDKL------DEENPKISAHILK 745
KS + E L+ + K+E + +K + ++P+ + LK
Sbjct: 745 KSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLK 804
Query: 746 ENDRT---QMQPLETLKLEVGENEQIVQIFGNKMEKTEEVKKEAEKSPKGKGRRSKTKDL 802
E+ + ++ E +K V E E+ ++ + K E +K A +PK + ++ K+
Sbjct: 805 EDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEK-APATPKTEEKKDSKKEE 863
Query: 803 SLEIIKISSFGQNEAGSEPHIEAHSLELSSLDNKNFSSATEDEIDQCVKEKKLKRKILGQ 862
+ + K + + E EP +E + S ++ K + + ++ KE K ++
Sbjct: 864 APK--KEAPKPKVEEKKEPAVE--KPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKED 919
Query: 863 SSPEKKIRIENGMEMTNTVSQERTSDCIGSEGM-KNLNFEQHFERENEGMPSLIAESNQC 921
+ P++K + E + ++E + E + + ++ ++ E P A++ +
Sbjct: 920 AKPKEKTEVAK-KEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKED 978
Query: 922 IQQLTSERFDSPAEETVNIPLKEDEDAMP 950
+ L+ E AE+ + +D+ P
Sbjct: 979 DKTLSKEPSKPKAEKAEKSSSTDQKDSKP 1007
Score = 54.3 bits (129), Expect = 7e-07
Identities = 121/667 (18%), Positives = 252/667 (37%), Gaps = 80/667 (11%)
Query: 7 PAYLTVGTDVSAKYRGAFCEAKIKTVKRLVKVKVLLKQDNTTQLVQDDQVKGPLRVGAIV 66
P +V T + K E KIK V++ K V++++ V ++ + +
Sbjct: 427 PKIPSVSTHIKVK-----SEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEE 481
Query: 67 ETRTSDGSFQEAIISKLTDASWYTVVFDDGDERTLRRTSLCLKGERHFAESETLDQLPLT 126
E + +G +E ++ + + ++ S + + AE+++ ++
Sbjct: 482 EGKEEEGGEEEE--AEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAK 539
Query: 127 NPEHFGTPVIAKKTNRGRRSSLPVTEDEKEEES---SEEEDEDKRRLNDELLGKVVSVVS 183
+P +P AK + S P + ++EE+ +E + +K + + K +
Sbjct: 540 SPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAK 599
Query: 184 ATERTEWYPALVISPSCNDDITVKKDQCLVRSFIDS--KFYSIARKDIKEVDILNLPESE 241
+ E+ + P + S + + K++ + + S K S +++ K + PE E
Sbjct: 600 SPEKAK-SPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKE 658
Query: 242 LSTKPGLQKASIFLKTRVVPDNWKMDISEILESSSSDDEDGPAEENDEEKEKEAKKTEEE 301
+ P K+ + + + P+ K + E+ S + P +E + K +K +
Sbjct: 659 EAKSPEKAKSPVKAEAKS-PEKAKSPVKA--EAKSPEKAKSPVKE----EAKSPEKAKSP 711
Query: 302 VPEEELDPEERDNFLQQLYKFMEDRGTPINKPPVLGYKDLNLFKLFRLVYHQGGCDNIDS 361
V EE PE+ + +++ K E +P+ + K +
Sbjct: 712 VKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEK---------------------A 750
Query: 362 GAVWKQIYMDLGIPILNSAASYNVKTAYRKYLYGFEEYCRSANIQFRTVHHHEPKVKEEK 421
+ K +D+ P + A ++ K F E +S VKEE
Sbjct: 751 KSPEKAKTLDVKSPEAKTPAKEEARSPADK----FPEKAKSP-------------VKEEV 793
Query: 422 KDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPRGRRRIARDVNSIK 481
K E++ + LK D + P E+ + E E + +E+++K P + + + K
Sbjct: 794 KSPEKA-KSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPK 852
Query: 482 KEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKKIKKQEDSDKD 541
E +++ +++ + V++ E A +K E + K + +KK+ E
Sbjct: 853 TEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPA 912
Query: 542 SDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVKYGRGKTQKIYEASIKSTEI 601
E +E ++ +E+TE + +D + EP K + + T++ E + K E
Sbjct: 913 KVEVKEDAKPKEKTE--VAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKE--EKAKKPEEK 968
Query: 602 DDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDSEKDEKRDEER 661
E KA L K K K +K K+ +KD K E+
Sbjct: 969 PKTE-----------------AKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKA 1011
Query: 662 QKSKRGR 668
+ K +
Sbjct: 1012 TEDKAAK 1018
Score = 46.2 bits (108), Expect = 2e-04
Identities = 101/477 (21%), Positives = 177/477 (37%), Gaps = 57/477 (11%)
Query: 416 KVKEEKKDLEESMEEALKLDQEMPLT--EVKSEPEENIDSNSESEREEIELKSPRGRR-- 471
K K K+ +S EA ++E + EVKS PE+ E + E KSP +
Sbjct: 549 KAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKS-PEKAKSPAKEEAKSPAEAKSPEKAKSP 607
Query: 472 --RIARDVNSIKKEIEEE-------KTEDKLKDNDTENKDVDDDYETAEKKENELLLGRK 522
A+ K ++EE K+ +K K E + ++ EK+E + K
Sbjct: 608 VKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAK 667
Query: 523 NTPKQKEKKIKKQEDSDK--DSDEEEEKSQEREETES--KCDSEGEEDEEDMEPCLTGTK 578
+ K + K +K + K E+ KS +EE +S K S +E+ + E + K
Sbjct: 668 SPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVK 727
Query: 579 VKVKYGRGKTQKIYEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPK 638
+ K + E + + E + + +A P DK K
Sbjct: 728 EEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARS---PADKFPEK 784
Query: 639 KK----------QKKKAKNKEDSEKDEK------------RDEERQKSKRGRPPLKSTLS 676
K +K K+ KED++ EK ++EE+ + + + P K
Sbjct: 785 AKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEE 844
Query: 677 SNMPYGLSKTANSEGKSDSCSSDSETEDALEKNL-------INEELSLKDELEKNENLND 729
P T +E K DS ++ ++A + + + + K E +K E +
Sbjct: 845 EKAP----ATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDK 900
Query: 730 DKLDEENPKISAHILKENDRTQMQPLETLKLEVGE-NEQIVQIFGNKMEKTEEVKKEAEK 788
K+ + A + + D + E K E + + K E E K E+
Sbjct: 901 KKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEE 960
Query: 789 SPKGKGRRSKTKDLSLEIIKISSFGQNEAGSEPHIEAHSLELSSLDNKNFSSATEDE 845
K + KT+ + E K S ++ +E ++ S + D+K ATED+
Sbjct: 961 KAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTD--QKDSKPPEKATEDK 1015
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 65.1 bits (157), Expect = 4e-10
Identities = 109/589 (18%), Positives = 235/589 (39%), Gaps = 86/589 (14%)
Query: 399 YCRSANIQFRTVHHHEPKVKEEKKDLEESMEEALKLDQEMPLTEVKSEPEE-------NI 451
Y R+ + + + ++E+ ++ E ++ ++ + S P+E N
Sbjct: 27 YQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNT 86
Query: 452 DSNSESEREEIELKSPRGRRRIARDVNSIK--KEIEEEKTEDKLKDNDTENKDVDDDYET 509
+ E +E + R RR R +++ KE + T+ L ++ + ET
Sbjct: 87 QVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENET 146
Query: 510 AEKKENELLLGRKNTPKQKEKKIKKQEDSDKDSDEEEEKSQEREETESKCDSEGEEDEED 569
EK+E K+ +Q+ +I++ E K + + + E + E K + E EE+E+
Sbjct: 147 TEKEE-------KSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDK-EKEEEEEEKP 198
Query: 570 MEPCLTGTKVKVKYGRGKTQKIYEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRII 629
+ +V+V T+ E + S + +G++
Sbjct: 199 KRGSIGENQVEVMVEEKTTESQEETVVMS--LKNGQI----------------------- 233
Query: 630 WPLDKGGPKKKQKKKAKNKEDS--EKDEKRDEERQKSKRGR--PPLKSTLSSNMPYGLS- 684
PK++++++ + E S EK E+ D+ER +++R R + + + ++
Sbjct: 234 ---SSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIAD 290
Query: 685 KTANSEGKSDSCSSDSETEDALEKNLINEELSLKDELEKNENLNDDKLDEENPKISAHIL 744
+ A E + + + + E +A E+ + EE E + + + EE +I
Sbjct: 291 ERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRI----- 345
Query: 745 KENDRTQMQPLETLKLEV-----------GENEQIVQIFGNKMEKTEEVKKEAEKSPKGK 793
KE ++ + + +K E E E+ ++ K K E KK A + K K
Sbjct: 346 KEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIK 405
Query: 794 GRRSKTK-------DLSLEIIKISSFGQNEAGSEPHIEAHSLELSSLDNKNFSSATEDEI 846
G + + K + + K+ + + G E + + ++K E +
Sbjct: 406 GEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKD 465
Query: 847 DQCVKEKKLKRKILGQSSPEK---KIRIENGMEMTNTVSQ-ERTSDCIGSEGMKNLNFEQ 902
++ K+K+ K ++ +K +++ +NG MT+ + E T G +
Sbjct: 466 EKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVD----- 520
Query: 903 HFERENEGMPSLIAESNQCIQQLTSERFDSPAEETVNIPLKEDEDAMPL 951
+E EG P + E+ + +++L R ++ +EE + K+ E A+ L
Sbjct: 521 --TKEAEGAPQV--EAGKRLEELRRRRGETESEEFEKLKQKQQEAALEL 565
Score = 56.2 bits (134), Expect = 2e-07
Identities = 85/470 (18%), Positives = 178/470 (37%), Gaps = 86/470 (18%)
Query: 409 TVHHHEPKVKEEKKDLEESMEEAL------KLDQEMPLTEVKSEPEENIDSNSESEREEI 462
++ ++ +V E+K E E + ++ E P E + E + S+ E EE
Sbjct: 202 SIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEED 261
Query: 463 ELKSPRGRRRIARDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRK 522
+ ++ R R+ + K +++K D+ + E K + E E +E E + +
Sbjct: 262 KERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEE 321
Query: 523 NTPKQKEKKIKKQE-----DSDKDSDEE----EEKSQEREETESKCDSEGEEDEEDMEPC 573
++ ++IK++E + + +EE EE+ + +EE + + E+ E
Sbjct: 322 KRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKA 381
Query: 574 LTGTKVKVKYGRGKTQKIYEASIKSTEID---DGEVLYLVHYYGWNVRYDEWVKADRIIW 630
+ + K K + E IK +++ +G+ W
Sbjct: 382 KVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGK------------------------W 417
Query: 631 PLDKGGPKKKQKKKAKNKEDSEKDEKRDEERQKSKRGRPPLKSTLSSNMPYGLSKTANSE 690
+K + K + K+ EK K +R+K + +P K E
Sbjct: 418 VNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFK---------------KEE 462
Query: 691 GKSDSCSSDSETEDALEKNLINEELSLKDELEKNENLNDDKLDEENPKISAHILKENDRT 750
K + D E ++ +K +++ + + K +N + H LK + T
Sbjct: 463 IKDEKIKKDKEPKE-----------EVKSFMDRKKGFTEVK--SQNGEFMTHKLKHTENT 509
Query: 751 QMQPLETLKLEVGENEQIVQIFGNKMEKTEEVKKEAEKSPKGKGRRSKTKDLSLEIIKIS 810
+P ++ E E Q+ K + EE+++ RR +T+ E +K
Sbjct: 510 FSRPGGRASVDTKEAEGAPQVEAGK--RLEELRR----------RRGETESEEFEKLKQK 557
Query: 811 SFGQNEAGSE-PHIEAHSLELSSLDNKNFSSATEDEIDQCVKEKKLKRKI 859
Q EA E ++ E + + ++E D+ ++E++ KR++
Sbjct: 558 ---QQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRL 604
Score = 53.9 bits (128), Expect = 9e-07
Identities = 51/196 (26%), Positives = 90/196 (45%), Gaps = 15/196 (7%)
Query: 409 TVHHHEPKVKEEKKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPR 468
T E K ++ KKD E E +D++ TEVKS+ E + + + E P
Sbjct: 457 TFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFM--THKLKHTENTFSRPG 514
Query: 469 GRRRIARDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQK 528
GR + ++E K ++L+ E + +++E ++K+ E L + K++
Sbjct: 515 GRASVDTKEAEGAPQVEAGKRLEELRRRRGETES--EEFEKLKQKQQEAALELEELKKKR 572
Query: 529 EKKIK---------KQEDSDKDSDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKV 579
E++ K KQE++D+ EEEEK + +EE E + E+ ++ E L+ K
Sbjct: 573 EERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKK 632
Query: 580 KVK--YGRGKTQKIYE 593
K +G + KI E
Sbjct: 633 PFKCFTPKGSSLKIEE 648
Score = 46.6 bits (109), Expect = 1e-04
Identities = 80/431 (18%), Positives = 172/431 (39%), Gaps = 58/431 (13%)
Query: 481 KKEIEEEKTED-KLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKKIKKQED-- 537
++E+ +K E+ +L+ + DDD E A ++ + KQ+E+ + + D
Sbjct: 7 RRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQV 66
Query: 538 -------------------SDKDSDEEE---EKSQEREETESKCDSEGEEDEEDMEPCLT 575
+ + D+E E+ REE K E E +++ +P +T
Sbjct: 67 EVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTIT 126
Query: 576 GTKVKVKYGRGKTQKIYEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKG 635
+ + R + + + E + RY E + + + K
Sbjct: 127 DASLSLPSRRMQNDTAENETTEKEEKSESR----------QERY-EIEETETVTKSYQKN 175
Query: 636 GPKKKQKKKAKNKEDSEKDEKRDEERQKSKRGRPPLKSTLSSNMPYGLSKTANSEGKSDS 695
+ ++ K KED EK+E+ +E+ ++ G ++ + +T K+
Sbjct: 176 DWRDAEENK---KEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQ 232
Query: 696 CSSDSETEDALEKNLINEELSLKDELEKNENLNDD----KLD-EENPKISAH----ILKE 746
SS+ E + E+ ++E+S +++E+ + + +L+ EE +I A I E
Sbjct: 233 ISSE-EPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADE 291
Query: 747 NDRTQMQ----PLETLKLEVGENEQIVQIFGNKMEKTEEVKKEAEKSPKGKGR-RSKTKD 801
R + + E + E E E++ + E+ + +K+E +++ + + R + + K
Sbjct: 292 RARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKR 351
Query: 802 LSLEIIKISSFGQNEAGSEPHIEAHSLELSSLD----NKNFSSATEDEIDQCVKEKKLKR 857
+ E +I + A A E + ++ NK + +K +K+++
Sbjct: 352 AAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQ 411
Query: 858 KILGQSSPEKK 868
KI G+ EKK
Sbjct: 412 KIEGKWVNEKK 422
Score = 31.2 bits (69), Expect = 6.5
Identities = 43/235 (18%), Positives = 94/235 (40%), Gaps = 10/235 (4%)
Query: 100 TLRRTSLCLKGER---HFAESETLD--QLPLTNPEHFGTPVIAKKTNRGRRSSLPVTEDE 154
T+ SL L R AE+ET + + + E + T +++ E+
Sbjct: 124 TITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEEN 183
Query: 155 KEEESSEEEDEDKRRLNDELLGKVVSVVSATERTEWYPALVISPSCNDDITVKKDQCLVR 214
K+E+ +EE+E+++ + V V+ + TE V+ N I+ ++ +
Sbjct: 184 KKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPK--QE 241
Query: 215 SFIDSKFYSIARKDIKEVDILNLPESELSTKPGLQKASIFLK--TRVVPDNWKMDISEIL 272
+ I+ + E + E+E + ++ I + ++ + +++ E
Sbjct: 242 EEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKA 301
Query: 273 ESSSSDDEDGPAEENDEEKEKEAKKTEEEVPEEE-LDPEERDNFLQQLYKFMEDR 326
+ + + E E+EK A + + + EEE EER ++ + E+R
Sbjct: 302 AAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEER 356
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 64.7 bits (156), Expect = 5e-10
Identities = 136/655 (20%), Positives = 252/655 (38%), Gaps = 98/655 (14%)
Query: 490 EDKLKDNDTENKDVDDDYETAE------KKENELLLGRKNTPKQKEKKIKKQEDSDKDSD 543
+ K K D+ D+D D AE KE E +K+ K+K++K K+ D D
Sbjct: 4 KQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQE---PQKSKGKKKKEKKKQDFDEDDILK 60
Query: 544 EEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVKYGRGKTQKIYEASIKSTEIDD 603
E EE S E + ++ ++ + E+ E T K K +GK Q + + E D
Sbjct: 61 ELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKD 120
Query: 604 GE----VLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDSEKDEKRDE 659
+ V Y + D++ K P G +K KK E+ E + K+ +
Sbjct: 121 SKSKKTAKPKVEMYSGSDDDDDFNKL-----PKKAKGKAQKSNKKWDGSEEDEDNSKKIK 175
Query: 660 ER-----------------QKSKRGRPPLKSTLSSNMPYGLSKTANSEGKSDSCSSDSET 702
ER Q K + K+ N+ G ++ ++ K + +
Sbjct: 176 ERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESG-NEDDDASFKIKTVAQKKAE 234
Query: 703 EDALEKNLINEELSLKDELEKNENLNDDKLDEENPKISAHILKENDRTQMQPLETLKLEV 762
+ E+ +EE + +L++ E L K D+ K S +E ET+K +V
Sbjct: 235 KKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEE---------ETVKSKV 285
Query: 763 GENEQIVQIFGNKMEKTEEVKKEAEKSPKGKGRRSKTKDLSLEIIKISSFGQNEAGSEPH 822
+ ++ K E + + E K K ++ K K E K G ++A
Sbjct: 286 TVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKK-KGEKEEKEKEKKKGPSKA----T 340
Query: 823 IEAHSLELSSLDNKNFSSATEDEIDQCVKEKKLKRKILGQSSPEKKIRIENGMEMTNTVS 882
++A L+ L E+E + +E+++KR ++ +++ R+E
Sbjct: 341 VKAMQEALAKLKE-------EEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQK 393
Query: 883 QERTSDCIGSEGMKNLNFEQHFERENEGMPSLIAESNQCIQQLTSERFDSPAEETV--NI 940
++ + + EG K L Q R A + ++ L ++ + P+++++
Sbjct: 394 EKERKERLKKEG-KLLTKSQREAR---------ARAEATLKLLQAQGVEVPSKDSLPKKR 443
Query: 941 PLKEDEDAMPLIGPETLVCHEVDLDDLDEKDKTSIEDVAVESSESNSLVSIPPALPPVVQ 1000
P+ ED+ + P+ L EV + ++ + + V E PP + P +
Sbjct: 444 PIYEDKKRKKI--PQQLESKEVS-ESMELCAAVEVMEQGVPEKEET-----PPPVEPEEE 495
Query: 1001 HNFSVASP---LTLSQDESRSVKSESDITIEVDSIAEESQEGLCERESANGFETNVASGT 1057
+ A ++ DE + + IEV EE +E E E E+
Sbjct: 496 EDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEE--EEEEEEDEES------ 547
Query: 1058 CSIIVQERESREKGQKRPSDGNSGLMAKKQKRTPKRTSAAAKNEKNGTGQSSDSE 1112
E E E+G+ S+G+ + +K + ++ S ++K SSDSE
Sbjct: 548 ------EEEEEEEGESEGSEGDE----EDEKVSDEKDSGKTLDKKPSKEMSSDSE 592
Score = 57.8 bits (138), Expect = 6e-08
Identities = 84/342 (24%), Positives = 149/342 (43%), Gaps = 23/342 (6%)
Query: 403 ANIQFRTVHHHEPKVKE-EKKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREE 461
A+ + +TV + + KE E+K +E + KL ++ L K + + +S + E E
Sbjct: 221 ASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEET 280
Query: 462 IELKSPRGRRRIARDVNSIKKEIEEEKTEDKLKDN---DTENKDVDDDYETAEKKENELL 518
++ K + D I E+ +T +D+ D + KD E+KE E
Sbjct: 281 VKSK-------VTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKK 333
Query: 519 LG-RKNTPKQKEKKIKK-QEDSDKDSDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTG 576
G K T K ++ + K +E+ ++ EEEE+ + EE E+K E ++E E
Sbjct: 334 KGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQK 393
Query: 577 TKVKVKYGRGKTQKIYEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGG 636
K + K K K+ S + L L+ G V + + R P+ +
Sbjct: 394 EKER-KERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKR---PIYEDK 449
Query: 637 PKKKQKKKAKNKEDSEKDEKRDEERQKSKRGRPPLKSTLSSNMPYGLSKTANSEGKSD-- 694
+KK ++ ++KE SE E + ++G P + T P T ++ G D
Sbjct: 450 KRKKIPQQLESKEVSESME-LCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDA-GLDDWE 507
Query: 695 SCSSDSETEDALEKNLINEELSLKDELEKNENLNDDKLDEEN 736
+ +SD ETE +E N ++ E+ E E+ E +++ DEE+
Sbjct: 508 AMASDEETE-KVEGNKVHIEVKENPE-EEEEEEEEEEEDEES 547
Score = 56.2 bits (134), Expect = 2e-07
Identities = 160/744 (21%), Positives = 276/744 (37%), Gaps = 165/744 (22%)
Query: 95 DGDERTLRRTSLCLKGERHFAESETLDQLPL-TNPEHFGTPVIAKKTNRGRRSSLPVTED 153
D D+ L L+ + A+ ET+ P N E F + KK +G++ S D
Sbjct: 54 DEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSF----D 109
Query: 154 EKEEESSEEEDEDKRRLNDELLGKVVSVVSATERTEWYPALVISPSCNDDITVK------ 207
+ + E E++D ++ +A + E Y S S +DD K
Sbjct: 110 DNDSEELEDKDSKSKK-------------TAKPKVEMY-----SGSDDDDDFNKLPKKAK 151
Query: 208 -KDQCLVRSFIDSKFYSIARKDIKEVDILNLPESELSTKPGLQKASIFLKTRV-VPDNWK 265
K Q + + S+ K IKE +N S+ ++ FL++R N K
Sbjct: 152 GKAQKSNKKWDGSEEDEDNSKKIKERSRIN------SSGESGDESDEFLQSRKGQKKNQK 205
Query: 266 MDISEILESSSSDDEDG-----PAEENDEEKEKEAKKTEEE-------VPEEELDPEERD 313
+ES + DD+ A++ E+KE+E KK +EE +EEL+ ++D
Sbjct: 206 NKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKD 265
Query: 314 NFLQQ--LYKFMEDRGTPINKPPVLGYKDLNLFKLFRLVYHQGGCDNIDSGAVWKQIYMD 371
Q+ KF E+ V ++ +D
Sbjct: 266 QSKQKESQRKFEEE-------------------------------------TVKSKVTVD 288
Query: 372 LGIPILNSAASYNVKTAYRKYLYGFEEYCRSANIQFRTVHHHEPKVKEEKKDLEESMEEA 431
G+ I S TA G ++ + + K K K ++M+EA
Sbjct: 289 TGV-IPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEA 347
Query: 432 L-KLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPRGRRRIARDVNSIKKEIEEEKTE 490
L KL +E K E EE I EE+E K + R+ ++ KK+ E+E+ E
Sbjct: 348 LAKLKEEE--ERQKREEEERI-----KRLEELEAKR-KEEERLEQEKRERKKQKEKERKE 399
Query: 491 DKLKDNDTENKDVDDDYETAE------KKENELLLGRKNTPK-------QKEKKIKKQED 537
K+ K + AE + + + + + PK +K KKI +Q +
Sbjct: 400 RLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLE 459
Query: 538 SDKDSDE---------EEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVKYGRGKT 588
S + S+ E+ E+EET + E EED ED G
Sbjct: 460 SKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTED---------------AGLD 504
Query: 589 QKIYEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNK 648
AS + TE +G +++ K P+++++++ + +
Sbjct: 505 DWEAMASDEETEKVEGNKVHIE----------------------VKENPEEEEEEEEEEE 542
Query: 649 EDSEKDEKRDEERQKSKRGRPPLKSTLSSNMPYG--LSKTANSEGKSDS--CSSDSETED 704
ED E +E+ +EE + +S G L K + E SDS S D T++
Sbjct: 543 EDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKE 602
Query: 705 ALEKNLINEELSLKDELEKNENLNDDKLDEENPKISAHILKENDRTQ-MQPLETLKLEVG 763
+ + K LE ++N+N +KL + H+ + +T+ + L ++ G
Sbjct: 603 ERAYDKAKRRIE-KRRLEHSKNVNTEKLRAPIICVLGHV--DTGKTKILDKLRHTHVQDG 659
Query: 764 ENEQIVQIFGNKMEKTEEVKKEAE 787
E I Q G E + ++ +
Sbjct: 660 EAGGITQQIGATNVPLEAINEQTK 683
Score = 43.5 bits (101), Expect = 0.001
Identities = 100/507 (19%), Positives = 187/507 (36%), Gaps = 79/507 (15%)
Query: 636 GPKKKQKKKAKNKEDSEKDE----------KRDEERQKSKRGRPPLKSTLSSNMPYGLSK 685
G K+K K + K+D + D +++E QKSK + K + L +
Sbjct: 2 GKKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKE 61
Query: 686 TANSEGKSDSCSSDSETEDALEKNLINEELSLKDELEKNENLNDDKLDEENPKISAHILK 745
++ +D ET EE + KD+ +K + D+ + + L+
Sbjct: 62 LEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDND----SEELE 117
Query: 746 ENDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTEEVKKEAEKSPKGKGRRSKTKDLSLE 805
+ D + + K+E+ F NK+ K + K +A+KS K + +D S +
Sbjct: 118 DKDSKSKKTAKP-KVEMYSGSDDDDDF-NKLPK--KAKGKAQKSNKKWDGSEEDEDNSKK 173
Query: 806 I---IKISSFGQNEAGSEPHIEAHSLELSSLDNK---NFSSATEDEIDQCVKEKKLKRKI 859
I +I+S G++ S+ +++ + + NK N S ED+ + K K
Sbjct: 174 IKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDD------DASFKIKT 227
Query: 860 LGQSSPEKKIRIENGMEMTNTVSQERTSDCIGSEGMKNLNFEQHFERENEGMPSLIAESN 919
+ Q EKK R ER ++ L ++ E + +
Sbjct: 228 VAQKKAEKKER-------------ERKKRDEEKAKLRKLKEKEELET---------GKKD 265
Query: 920 QCIQQLTSERFDSPAEETVNIPLKEDEDAMPLIGPETLVCHEVDLDDLDEKDKTSIEDVA 979
Q Q+ + +F+ EETV + D +P + + D+ +K K +
Sbjct: 266 QSKQKESQRKFE---EETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKK 322
Query: 980 VESSESNSLVSIPPALPPVVQHNFSVASPLTLSQDESRSVKSESDITIEVDSIAEESQEG 1039
E E P+ V ++A L ++E R + E EE +
Sbjct: 323 GEKEEKEKEKKKGPSKATVKAMQEALAK---LKEEEERQKREE-----------EERIKR 368
Query: 1040 LCERESANGFETNVASGTCSIIVQERESREKGQKRPSDGNSGLMAKKQKRTPKRTSAAAK 1099
L E E+ E + E+E RE+ +++ + L + + T + A A+
Sbjct: 369 LEELEAKRKEEERL----------EQEKRERKKQKEKERKERLKKEGKLLTKSQREARAR 418
Query: 1100 NEKNGTGQSSDSEDLPVLDNSSKCTPV 1126
E + ++P D+ K P+
Sbjct: 419 AEATLKLLQAQGVEVPSKDSLPKKRPI 445
Score = 35.4 bits (80), Expect = 0.35
Identities = 62/292 (21%), Positives = 117/292 (40%), Gaps = 41/292 (14%)
Query: 963 DLDDLDEKDKTSIE---DVAVESSESNSLVSIPPALPPVVQHNFSVASPLTLSQDESRSV 1019
+L+D D K K + + ++ S + + +P Q + +D S+ +
Sbjct: 115 ELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKI 174
Query: 1020 KSESDITIEVDSIAEESQEGLCERESA-------------NGFETNVASGTCSIIVQER- 1065
K S I +S +ES E L R+ +G E + AS + Q++
Sbjct: 175 KERSRINSSGES-GDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKA 233
Query: 1066 ESREKGQKRPSDGNSGLMAKKQKR---TPKRTSAAAKNEKNG----TGQSSDSEDLPVLD 1118
E +E+ +K+ + + L K+K T K+ + K + T +S + D V+
Sbjct: 234 EKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIP 293
Query: 1119 NSSKC--TPVKHLNVSKPQKLARSPARISPHIKDGEKD-KHREKHPNSSPRTYKWSFQ-- 1173
S + TP + ++ K + + K GEK+ K +EK S T K +
Sbjct: 294 ASEEKAETPTAAEDDNEGDKKKKDKKK-----KKGEKEEKEKEKKKGPSKATVKAMQEAL 348
Query: 1174 --LNELDNMNSTERISFLQEKLQEIRKYYMSLKSEVATIDRRRKRLKKKDRE 1223
L E + E +E+++ + + K E +R+R K+K++E
Sbjct: 349 AKLKEEEERQKREE----EERIKRLEELEAKRKEEERLEQEKRERKKQKEKE 396
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.306 0.126 0.342
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,872,923
Number of Sequences: 37866
Number of extensions: 2580170
Number of successful extensions: 47998
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 536
Number of HSP's successfully gapped in prelim test: 1207
Number of HSP's that attempted gapping in prelim test: 16049
Number of HSP's gapped (non-prelim): 19794
length of query: 1257
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1143
effective length of database: 13,930,794
effective search space: 15922897542
effective search space used: 15922897542
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.