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Search of human proteins with 114431244
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|114431244 von Willebrand factor C and EGF domains [Homo
sapiens]
(955 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|114431244 von Willebrand factor C and EGF domains [Homo sapiens] 2099 0.0
gi|209571519 cysteine rich BMP regulator 2 isoform 1 [Homo sapiens] 254 4e-67
gi|209571521 cysteine rich BMP regulator 2 isoform 2 [Homo sapiens] 253 6e-67
gi|108773804 Fraser syndrome 1 [Homo sapiens] 145 1e-34
gi|88758613 CD93 antigen precursor [Homo sapiens] 142 1e-33
gi|75709198 nephronectin [Homo sapiens] 137 4e-32
gi|10092639 cysteine-rich motor neuron 1 [Homo sapiens] 135 1e-31
gi|34734064 fibulin 1 isoform B precursor [Homo sapiens] 129 1e-29
gi|34734068 fibulin 1 isoform A precursor [Homo sapiens] 129 1e-29
gi|34734066 fibulin 1 isoform D [Homo sapiens] 129 1e-29
gi|34734062 fibulin 1 isoform C precursor [Homo sapiens] 129 1e-29
gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens] 128 2e-29
gi|13124888 epidermal growth factor-like protein 6 precursor [Ho... 128 3e-29
gi|24430141 fibrillin 1 precursor [Homo sapiens] 125 1e-28
gi|37693519 BMP-binding endothelial regulator precursor protein ... 125 1e-28
gi|190343004 EGF-containing fibulin-like extracellular matrix pr... 123 7e-28
gi|86788132 EGF-containing fibulin-like extracellular matrix pro... 122 1e-27
gi|86788015 EGF-containing fibulin-like extracellular matrix pro... 122 1e-27
gi|9665262 EGF-containing fibulin-like extracellular matrix prot... 122 1e-27
gi|66346695 fibrillin 2 precursor [Homo sapiens] 121 4e-27
gi|10190748 CEGP1 protein [Homo sapiens] 120 5e-27
gi|56237021 fibrillin 3 precursor [Homo sapiens] 120 5e-27
gi|19743803 fibulin 5 precursor [Homo sapiens] 120 8e-27
gi|4557733 latent transforming growth factor beta binding protei... 118 3e-26
gi|110347437 latent transforming growth factor beta binding prot... 116 1e-25
gi|110347412 latent transforming growth factor beta binding prot... 116 1e-25
gi|110347431 latent transforming growth factor beta binding prot... 116 1e-25
gi|31377568 signal peptide, CUB domain, EGF-like 3 [Homo sapiens] 115 1e-25
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens] 112 2e-24
gi|46249414 latent transforming growth factor beta binding prote... 111 4e-24
>gi|114431244 von Willebrand factor C and EGF domains [Homo sapiens]
Length = 955
Score = 2099 bits (5438), Expect = 0.0
Identities = 955/955 (100%), Positives = 955/955 (100%)
Query: 1 MWAGLLLRAACVALLLPGAPARGYTGRKPPGHFAAERRRLGPHVCLSGFGSGCCPGWAPS 60
MWAGLLLRAACVALLLPGAPARGYTGRKPPGHFAAERRRLGPHVCLSGFGSGCCPGWAPS
Sbjct: 1 MWAGLLLRAACVALLLPGAPARGYTGRKPPGHFAAERRRLGPHVCLSGFGSGCCPGWAPS 60
Query: 61 MGGGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGATCPETHGPCGEYGCDLTCNHGGCQE 120
MGGGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGATCPETHGPCGEYGCDLTCNHGGCQE
Sbjct: 61 MGGGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGATCPETHGPCGEYGCDLTCNHGGCQE 120
Query: 121 VARVCPVGFSMTETAVGIRCTDIDECVTSSCEGHCVNTEGGFVCECGPGMQLSADRHSCQ 180
VARVCPVGFSMTETAVGIRCTDIDECVTSSCEGHCVNTEGGFVCECGPGMQLSADRHSCQ
Sbjct: 121 VARVCPVGFSMTETAVGIRCTDIDECVTSSCEGHCVNTEGGFVCECGPGMQLSADRHSCQ 180
Query: 181 DTDECLGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNT 240
DTDECLGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNT
Sbjct: 181 DTDECLGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNT 240
Query: 241 VGSFLCTCRPGFRLRADRVSCEAFPKAVLAPSAILQPRQHPSKMLLLLPEAGRPALSPGH 300
VGSFLCTCRPGFRLRADRVSCEAFPKAVLAPSAILQPRQHPSKMLLLLPEAGRPALSPGH
Sbjct: 241 VGSFLCTCRPGFRLRADRVSCEAFPKAVLAPSAILQPRQHPSKMLLLLPEAGRPALSPGH 300
Query: 301 SPPSGAPGPPAGVRTTRLPSPTPRLPTSSPSAPVWLLSTLLATPVPTASLLGNLRPPSLL 360
SPPSGAPGPPAGVRTTRLPSPTPRLPTSSPSAPVWLLSTLLATPVPTASLLGNLRPPSLL
Sbjct: 301 SPPSGAPGPPAGVRTTRLPSPTPRLPTSSPSAPVWLLSTLLATPVPTASLLGNLRPPSLL 360
Query: 361 QGEVMGTPSSPRGPESPRLAAGPSPCWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVR 420
QGEVMGTPSSPRGPESPRLAAGPSPCWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVR
Sbjct: 361 QGEVMGTPSSPRGPESPRLAAGPSPCWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVR 420
Query: 421 CEAACSHPIPSRDGGCCPSCTGCFHSGVVRAEGDVFSPPNENCTVCVCLAGNVSCISPEC 480
CEAACSHPIPSRDGGCCPSCTGCFHSGVVRAEGDVFSPPNENCTVCVCLAGNVSCISPEC
Sbjct: 421 CEAACSHPIPSRDGGCCPSCTGCFHSGVVRAEGDVFSPPNENCTVCVCLAGNVSCISPEC 480
Query: 481 PSGPCQTPPQTDCCTCVPVRCYFHGRWYADGAVFSGGGDECTTCVCQNGEVECSFMPCPE 540
PSGPCQTPPQTDCCTCVPVRCYFHGRWYADGAVFSGGGDECTTCVCQNGEVECSFMPCPE
Sbjct: 481 PSGPCQTPPQTDCCTCVPVRCYFHGRWYADGAVFSGGGDECTTCVCQNGEVECSFMPCPE 540
Query: 541 LACPREEWRLGPGQCCFTCQEPTPSTGCSLDDNGVEFPIGQIWSPGDPCELCICQADGSV 600
LACPREEWRLGPGQCCFTCQEPTPSTGCSLDDNGVEFPIGQIWSPGDPCELCICQADGSV
Sbjct: 541 LACPREEWRLGPGQCCFTCQEPTPSTGCSLDDNGVEFPIGQIWSPGDPCELCICQADGSV 600
Query: 601 SCKRTDCVDSCPHPIRIPGQCCPDCSAGCTYTGRIFYNNETFPSVLDPCLSCICLLGSVA 660
SCKRTDCVDSCPHPIRIPGQCCPDCSAGCTYTGRIFYNNETFPSVLDPCLSCICLLGSVA
Sbjct: 601 SCKRTDCVDSCPHPIRIPGQCCPDCSAGCTYTGRIFYNNETFPSVLDPCLSCICLLGSVA 660
Query: 661 CSPVDCPITCTYPFHPDGECCPVCRDCNYEGRKVANGQVFTLDDEPCTRCTCQLGEVSCE 720
CSPVDCPITCTYPFHPDGECCPVCRDCNYEGRKVANGQVFTLDDEPCTRCTCQLGEVSCE
Sbjct: 661 CSPVDCPITCTYPFHPDGECCPVCRDCNYEGRKVANGQVFTLDDEPCTRCTCQLGEVSCE 720
Query: 721 KVPCQRACADPALLPGDCCSSCPDSLSPLEEKQGLSPHGNVAFSKAGRSLHGDTEAPVNC 780
KVPCQRACADPALLPGDCCSSCPDSLSPLEEKQGLSPHGNVAFSKAGRSLHGDTEAPVNC
Sbjct: 721 KVPCQRACADPALLPGDCCSSCPDSLSPLEEKQGLSPHGNVAFSKAGRSLHGDTEAPVNC 780
Query: 781 SSCPGPPTASPSRPVLHLLQLLLRTNLMKTQTLPTSPAGAHGPHSLALGLTATFPGEPGA 840
SSCPGPPTASPSRPVLHLLQLLLRTNLMKTQTLPTSPAGAHGPHSLALGLTATFPGEPGA
Sbjct: 781 SSCPGPPTASPSRPVLHLLQLLLRTNLMKTQTLPTSPAGAHGPHSLALGLTATFPGEPGA 840
Query: 841 SPRLSPGPSTPPGAPTLPLASPGAPQPPPVTPERSFSASGAQIVSRWPPLPGTLLTEASA 900
SPRLSPGPSTPPGAPTLPLASPGAPQPPPVTPERSFSASGAQIVSRWPPLPGTLLTEASA
Sbjct: 841 SPRLSPGPSTPPGAPTLPLASPGAPQPPPVTPERSFSASGAQIVSRWPPLPGTLLTEASA 900
Query: 901 LSMMDPSPSKTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPPVGASRGEESTM 955
LSMMDPSPSKTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPPVGASRGEESTM
Sbjct: 901 LSMMDPSPSKTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPPVGASRGEESTM 955
>gi|209571519 cysteine rich BMP regulator 2 isoform 1 [Homo sapiens]
Length = 1503
Score = 254 bits (648), Expect = 4e-67
Identities = 159/446 (35%), Positives = 195/446 (43%), Gaps = 38/446 (8%)
Query: 362 GEVMGTPSSPRGPESPRLAAGPS--PCWHLGAMHESRSRWTEPG--CSQCWCEDGKVTCE 417
G V+ P+ + P P A PS C + ++ + +T+ C C C+DG VTC
Sbjct: 399 GAVLCPPAPCQHPTQPPGACCPSCDSCTYHSQVYANGQNFTDADSPCHACHCQDGTVTCS 458
Query: 418 KVRC-EAACSHPIPSRDGGCCPSCTGCFHSGVVRAEGDVFSPPNENCTVCVCLAGNVSCI 476
V C C+ P S G CCP C C V +G+ FS P + C C C G+ C
Sbjct: 459 LVDCPPTTCARP-QSGPGQCCPRCPDCILEEEVFVDGESFSHPRDPCQECRCQEGHAHCQ 517
Query: 477 SPECPSGPCQTPPQTDCCTCVPVRCYFHGRWYADGAVFSGGGDECTTCVCQNGEVECSFM 536
CP PC P CC C F G+ Y GA F D C C C +G V+C
Sbjct: 518 PRPCPRAPCAHPLPGTCCPNDCSGCAFGGKEYPSGADFPHPSDPCRLCRCLSGNVQCLAR 577
Query: 537 PCPELACPREEWRLGPGQCCFTCQEPTPSTGCSLDDNGVEFPIGQIWSPGDPCELCICQA 596
C L CP E L PG+CC C P GC PGDPC C+C
Sbjct: 578 RCVPLPCP--EPVLLPGECCPQCPAP---AGCPRPGAAHARHQEYFSPPGDPCRRCLC-L 631
Query: 597 DGSVSCKRTDCVDS-CPHPIRIPGQCCPDCSAGCTYTGRIFYNNETFPSVLDPCLSCICL 655
DGSVSC+R C + C HP + G CCP C GC Y G+ F + E FPS C C+C
Sbjct: 632 DGSVSCQRLPCPPAPCAHPRQ--GPCCPSCD-GCLYQGKEFASGERFPSPTAACHLCLCW 688
Query: 656 LGSVACSPVDC-PITCTYPFHPDGECCPVCRDCNYEGRKVANGQVFTLDDEPCTRCTCQL 714
GSV+C P C P C PF G+CCP C C Y G + Q F EPC CTC
Sbjct: 689 EGSVSCEPKACAPALC--PFPARGDCCPDCDGCEYLGESYLSNQEFPDPREPCNLCTCLG 746
Query: 715 GEVSCEKVPCQ-RACADPALLPGDCCSSCPDSLSPLEEKQGLSPHGNVAFS--------K 765
G V+C + PC+ C+ P + G CC +C QG HG S
Sbjct: 747 GFVTCGRRPCEPPGCSHPLIPSGHCCPTC----------QGCRYHGVTTASGETLPDPLD 796
Query: 766 AGRSLHGDTEAPVNCSSCPGPPTASP 791
SL E + C P PP P
Sbjct: 797 PTCSLCTCQEGSMRCQKKPCPPALCP 822
Score = 232 bits (591), Expect = 1e-60
Identities = 149/412 (36%), Positives = 178/412 (43%), Gaps = 49/412 (11%)
Query: 398 RWTEPG--CSQCWCEDGKVTCEKVRCEAA-CSHPIPSRDGGCCPSCTGCFHSGVVRAEGD 454
+W G C+ C C+DG C V C A C HP G CCPSC C + V A G
Sbjct: 378 QWEPDGRPCTACVCQDGVPKCGAVLCPPAPCQHPTQP-PGACCPSCDSCTYHSQVYANGQ 436
Query: 455 VFSPPNENCTVCVCLAGNVSCISPECPSGPCQTPPQ--TDCCTCVPVRCYFHGRWYADGA 512
F+ + C C C G V+C +CP C P CC P C + DG
Sbjct: 437 NFTDADSPCHACHCQDGTVTCSLVDCPPTTCARPQSGPGQCCPRCP-DCILEEEVFVDGE 495
Query: 513 VFSGGGDECTTCVCQNGEVECSFMPCPELACPREEWRLGPGQCCFTCQEPTPSTGCSLDD 572
FS D C C CQ G C PCP C PG CC P +GC+
Sbjct: 496 SFSHPRDPCQECRCQEGHAHCQPRPCPRAPCAHPL----PGTCC-----PNDCSGCAF-- 544
Query: 573 NGVEFPIGQIW-SPGDPCELCICQADGSVSCKRTDCVD-SCPHPIRIPGQCCPDC--SAG 628
G E+P G + P DPC LC C G+V C CV CP P+ +PG+CCP C AG
Sbjct: 545 GGKEYPSGADFPHPSDPCRLCRC-LSGNVQCLARRCVPLPCPEPVLLPGECCPQCPAPAG 603
Query: 629 CTYTGRIF-YNNETFPSVLDPCLSCICLLGSVACSPVDC-PITCTYPFHPDGECCPVCRD 686
C G + E F DPC C+CL GSV+C + C P C +P G CCP C
Sbjct: 604 CPRPGAAHARHQEYFSPPGDPCRRCLCLDGSVSCQRLPCPPAPCAHP--RQGPCCPSCDG 661
Query: 687 CNYEGRKVANGQVFTLDDEPCTRCTCQLGEVSCEKVPCQRACADPALLP----GDCCSSC 742
C Y+G++ A+G+ F C C C G VSCE +ACA PAL P GDCC C
Sbjct: 662 CLYQGKEFASGERFPSPTAACHLCLCWEGSVSCE----PKACA-PALCPFPARGDCCPDC 716
Query: 743 PDSLSPLEEKQGLSPHGNVAFSKAGRSLHGDTEAPVNCSSCPGPPTASPSRP 794
E G S N F D P N +C G RP
Sbjct: 717 DGC-----EYLGESYLSNQEFP--------DPREPCNLCTCLGGFVTCGRRP 755
Score = 230 bits (587), Expect = 4e-60
Identities = 135/368 (36%), Positives = 166/368 (45%), Gaps = 33/368 (8%)
Query: 383 PSPCWHLGAMHESRSRWTEPG--CSQCWCEDGKVTCEKVRCEAACSHPIPSRDGGCCPSC 440
P C G+ E WT PG C C C +G + C + C + C +P G CCP C
Sbjct: 190 PICCTEGGSHWEHGQEWTTPGDPCRICRCLEGHIQCRQRECASLCPYPARPLPGTCCPVC 249
Query: 441 TGCFHSGVVRAEGDVFSPPNENCTVCVCLAGNVSCISPECPSGPCQTPPQT--DCCTCVP 498
GCF +G G+ + C+ C C G+V C CP PC+ P + CC V
Sbjct: 250 DGCFLNGREHRSGEPVG-SGDPCSHCRCANGSVQCEPLPCPPVPCRHPGKIPGQCCP-VC 307
Query: 499 VRCYFHGRWYADGAVFS-GGGDECTTCVCQNGEVECSFMPCPELAC--PREEWRLGPGQC 555
C + G Y F C C CQ GEV C CP C P +L P
Sbjct: 308 DGCEYQGHQYQSQETFRLQERGLCVRCSCQAGEVSCEEQECPVTPCALPASGRQLCP--- 364
Query: 556 CFTCQEPTPSTGCSLDDNGVEFPIGQIWSP-GDPCELCICQADGSVSCKRTDCVDS-CPH 613
C LD G EF G W P G PC C+CQ DG C C + C H
Sbjct: 365 -----------ACELD--GEEFAEGVQWEPDGRPCTACVCQ-DGVPKCGAVLCPPAPCQH 410
Query: 614 PIRIPGQCCPDCSAGCTYTGRIFYNNETFPSVLDPCLSCICLLGSVACSPVDC-PITCTY 672
P + PG CCP C + CTY +++ N + F PC +C C G+V CS VDC P TC
Sbjct: 411 PTQPPGACCPSCDS-CTYHSQVYANGQNFTDADSPCHACHCQDGTVTCSLVDCPPTTCAR 469
Query: 673 PFHPDGECCPVCRDCNYEGRKVANGQVFTLDDEPCTRCTCQLGEVSCEKVPCQRA-CADP 731
P G+CCP C DC E +G+ F+ +PC C CQ G C+ PC RA CA P
Sbjct: 470 PQSGPGQCCPRCPDCILEEEVFVDGESFSHPRDPCQECRCQEGHAHCQPRPCPRAPCAHP 529
Query: 732 ALLPGDCC 739
LPG CC
Sbjct: 530 --LPGTCC 535
Score = 228 bits (582), Expect = 2e-59
Identities = 139/397 (35%), Positives = 176/397 (44%), Gaps = 39/397 (9%)
Query: 357 PSLLQGEVMGTPSSPRGPESPRLAAGPSPCWHLGAMHESRSRWTEPG---CSQCWCEDGK 413
P LL GE P+ P A P P GA H + P C +C C DG
Sbjct: 587 PVLLPGECC--------PQCPAPAGCPRP----GAAHARHQEYFSPPGDPCRRCLCLDGS 634
Query: 414 VTCEKVRCEAA-CSHPIPSRDGGCCPSCTGCFHSGVVRAEGDVFSPPNENCTVCVCLAGN 472
V+C+++ C A C+HP R G CCPSC GC + G A G+ F P C +C+C G+
Sbjct: 635 VSCQRLPCPPAPCAHP---RQGPCCPSCDGCLYQGKEFASGERFPSPTAACHLCLCWEGS 691
Query: 473 VSCISPECPSGPCQTPPQTDCCTCVPVRCYFHGRWYADGAVFSGGGDECTTCVCQNGEVE 532
VSC C C P + DCC C + G Y F + C C C G V
Sbjct: 692 VSCEPKACAPALCPFPARGDCCPDCD-GCEYLGESYLSNQEFPDPREPCNLCTCLGGFVT 750
Query: 533 CSFMPCPELACPREEWRLGPGQCCFTCQEPTPSTGCSLDDNGVEFPIGQ-IWSPGDP-CE 590
C PC C + G CC TCQ GC +GV G+ + P DP C
Sbjct: 751 CGRRPCEPPGCSHP--LIPSGHCCPTCQ------GCRY--HGVTTASGETLPDPLDPTCS 800
Query: 591 LCICQADGSVSCKRTDCVDS-CPHPIRIPGQC-CPDCSAGCTYTGRIFYNNETFPSVLDP 648
LC CQ +GS+ C++ C + CPHP PG C CP C + C GR + E F
Sbjct: 801 LCTCQ-EGSMRCQKKPCPPALCPHPS--PGPCFCPVCHS-CLSQGREHQDGEEFEGPAGS 856
Query: 649 CLSCICLLGSVACSPVDCP-ITCTYPFHPDGECCPVCRDCNYEGRKVANGQVFTLDDEPC 707
C C C G V+C + CP + C G CCP CR C G + G + D C
Sbjct: 857 CEWCRCQAGQVSCVRLQCPPLPCKLQVTERGSCCPRCRGCLAHGEEHPEGSRWVPPDSAC 916
Query: 708 TRCTCQLGEVSCEKVPCQRACADPALLPGDCCSSCPD 744
+ C C G V+C ++ C +CA P P DCC C D
Sbjct: 917 SSCVCHEGVVTCARIQCISSCAQPRQGPHDCCPQCSD 953
Score = 216 bits (551), Expect = 6e-56
Identities = 237/852 (27%), Positives = 308/852 (36%), Gaps = 199/852 (23%)
Query: 30 PGHFAAERRRLGPHVCLSG--FGSGCCPGWAPSMGGGHCTLPLCSFG---CGSGICIAPN 84
P A R+L P L G F G W P G CT +C G CG+ +C P
Sbjct: 352 PCALPASGRQLCPACELDGEEFAEGV--QWEPD--GRPCTACVCQDGVPKCGAVLC-PPA 406
Query: 85 VCSCQDGEQGATCPET-----HGPCGEYGCDLT-----CNHGGCQEVARVC------PVG 128
C GA CP H G + T C+ CQ+ C P
Sbjct: 407 PCQHPTQPPGACCPSCDSCTYHSQVYANGQNFTDADSPCHACHCQDGTVTCSLVDCPPTT 466
Query: 129 FSMTETAVGIRCTDIDECVTSSCEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDECLGT 188
+ ++ G C +C+ E FV G S R CQ+
Sbjct: 467 CARPQSGPGQCCPRCPDCILE---------EEVFV----DGESFSHPRDPCQE------- 506
Query: 189 PCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSC----------- 237
C C+ G H H C C PL C + C
Sbjct: 507 --------------CRCQEG-HAHCQPRPCPRA-PCAHPLPGTCCPNDCSGCAFGGKEYP 550
Query: 238 ------HNTVGSFLCTCRPG-FRLRADRVSCEAFPKAVLAPSAILQPRQHPSKMLLLLPE 290
H + LC C G + A R P+ VL P P+ P
Sbjct: 551 SGADFPHPSDPCRLCRCLSGNVQCLARRCVPLPCPEPVLLPGECCPQCPAPAGC----PR 606
Query: 291 AGRPALSPGHSPPSGAPGPPA--------GVRTTRLPSPT-----PRLPTSSPSAPVWL- 336
G A H PG P V RLP P PR PS L
Sbjct: 607 PG--AAHARHQEYFSPPGDPCRRCLCLDGSVSCQRLPCPPAPCAHPRQGPCCPSCDGCLY 664
Query: 337 ----LSTLLATPVPTASLLGNLRPPSLLQGEVMGTPSSPRGPESPRLAAGP-----SPCW 387
++ P PTA+ L +G V P + P A G C
Sbjct: 665 QGKEFASGERFPSPTAACHLCL----CWEGSVSCEPKACAPALCPFPARGDCCPDCDGCE 720
Query: 388 HLGAMHESRSRWTEPG--CSQCWCEDGKVTCEKVRCEA-ACSHP-IPSRDGGCCPSCTGC 443
+LG + S + +P C+ C C G VTC + CE CSHP IPS G CCP+C GC
Sbjct: 721 YLGESYLSNQEFPDPREPCNLCTCLGGFVTCGRRPCEPPGCSHPLIPS--GHCCPTCQGC 778
Query: 444 FHSGVVRAEGDVFSPP-NENCTVCVCLAGNVSCISPECPSGPCQTPPQTDCCTCVPVRCY 502
+ GV A G+ P + C++C C G++ C CP C P C V C
Sbjct: 779 RYHGVTTASGETLPDPLDPTCSLCTCQEGSMRCQKKPCPPALCPHPSPGPCFCPVCHSCL 838
Query: 503 FHGRWYADGAVFSGGGDECTTCVCQNGEVECSFMPCPEL-----------ACPREEWRLG 551
GR + DG F G C C CQ G+V C + CP L CPR L
Sbjct: 839 SQGREHQDGEEFEGPAGSCEWCRCQAGQVSCVRLQCPPLPCKLQVTERGSCCPRCRGCLA 898
Query: 552 PG-------------------------------QCCFTCQEPT--PSTGC----SLDDNG 574
G QC +C +P P C + G
Sbjct: 899 HGEEHPEGSRWVPPDSACSSCVCHEGVVTCARIQCISSCAQPRQGPHDCCPQCSDCEHEG 958
Query: 575 VEFPIGQIWSPG-DPCELCIC--QADG--SVSCKRTDCVD--SCPHPIRI----PGQCCP 623
++ G+ + PG DPCE+CIC Q +G S+ C R C CP P ++ P CCP
Sbjct: 959 RKYEPGESFQPGADPCEVCICEPQPEGPPSLRCHRRQCPSLVGCP-PSQLLPPGPQHCCP 1017
Query: 624 DCSAGCTYTGRIFYNNETFPSVLDPCLSCIC-----LLGSVACSPVDCPITCTYPFHPDG 678
C+ + +E P DPC +C C L AC + CP++ + P G
Sbjct: 1018 TCAEALSNCSEGLLGSELAPP--DPCYTCQCQDLTWLCIHQACPELSCPLSERHT--PPG 1073
Query: 679 ECCPVCR----DCNYEGRKVANGQVFTLDDEPCTRCTCQLGEVSCEKVPCQ-RACAD--- 730
CCPVCR C ++GR+VA+G+ +T+D CT C+C G V C+ C +C
Sbjct: 1074 SCCPVCRAPTQSCVHQGREVASGERWTVDT--CTSCSCMAGTVRCQSQRCSPLSCGPDKA 1131
Query: 731 PALLPGDCCSSC 742
PAL PG CC C
Sbjct: 1132 PALSPGSCCPRC 1143
Score = 212 bits (540), Expect = 1e-54
Identities = 140/390 (35%), Positives = 169/390 (43%), Gaps = 51/390 (13%)
Query: 360 LQGEVMGTPSSPRGPESPRLAAGPSPCWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKV 419
LQ V S P SP+ CW LG +RW C+ C C+DG C
Sbjct: 77 LQTRVRQLESCECHPASPQ-------CWGLGRAWPEGARWEPDACTACVCQDGAAHC--- 126
Query: 420 RCEAACSHPIPSRDGGCCPSCTGCFHSGVVRAEGDVFSPPNENCTVCVCLAGNVSCISPE 479
+H P C GC +G G+ FSP + CT C CL G V C P
Sbjct: 127 ---GPQAH---------LPHCRGCSQNGQTYGNGETFSP--DACTTCRCLTGAVQCQGPS 172
Query: 480 CPSGPCQ---TPPQTDCCTCVPVRCYFHGRWYADGAVFSGGGDECTTCVCQNGEVECSFM 536
C C TPP +CC P+ C G + G ++ GD C C C G ++C
Sbjct: 173 CSELNCLESCTPPG-ECC---PICCTEGGSHWEHGQEWTTPGDPCRICRCLEGHIQCRQR 228
Query: 537 PCPELACPREEWRLGPGQCCFTCQEPTPSTGCSLDDNGVEFPIGQIWSPGDPCELCICQA 596
C L CP L PG CC C GC L NG E G+ GDPC C C A
Sbjct: 229 ECASL-CPYPARPL-PGTCCPVCD------GCFL--NGREHRSGEPVGSGDPCSHCRC-A 277
Query: 597 DGSVSCKRTDCVD-SCPHPIRIPGQCCPDCSAGCTYTGRIFYNNETFP-SVLDPCLSCIC 654
+GSV C+ C C HP +IPGQCCP C GC Y G + + ETF C+ C C
Sbjct: 278 NGSVQCEPLPCPPVPCRHPGKIPGQCCPVCD-GCEYQGHQYQSQETFRLQERGLCVRCSC 336
Query: 655 LLGSVACSPVDCPIT-CTYPFHPDGECCPVCRDCNYEGRKVANGQVFTLDDEPCTRCTCQ 713
G V+C +CP+T C P + CP C +G + A G + D PCT C CQ
Sbjct: 337 QAGEVSCEEQECPVTPCALPAS-GRQLCPACE---LDGEEFAEGVQWEPDGRPCTACVCQ 392
Query: 714 LGEVSCEKVPCQRA-CADPALLPGDCCSSC 742
G C V C A C P PG CC SC
Sbjct: 393 DGVPKCGAVLCPPAPCQHPTQPPGACCPSC 422
Score = 108 bits (269), Expect = 3e-23
Identities = 71/216 (32%), Positives = 89/216 (41%), Gaps = 27/216 (12%)
Query: 574 GVEFPIGQIWSPGDPCELCICQADGSVSCKRTDCVDSCPHPIRIPGQCCPDCSAGCTYTG 633
G +P G W P D C C+CQ DG+ C P P C GC+ G
Sbjct: 100 GRAWPEGARWEP-DACTACVCQ-DGAAHCG--------------PQAHLPHCR-GCSQNG 142
Query: 634 RIFYNNETFPSVLDPCLSCICLLGSVACSPVDCP-ITCTYPFHPDGECCPVCRDCNYEGR 692
+ + N ETF D C +C CL G+V C C + C P GECCP+C C G
Sbjct: 143 QTYGNGETFSP--DACTTCRCLTGAVQCQGPSCSELNCLESCTPPGECCPIC--CTEGGS 198
Query: 693 KVANGQVFTLDDEPCTRCTCQLGEVSCEKVPCQRACADPAL-LPGDCCSSCPDSLSPLEE 751
+GQ +T +PC C C G + C + C C PA LPG CC C E
Sbjct: 199 HWEHGQEWTTPGDPCRICRCLEGHIQCRQRECASLCPYPARPLPGTCCPVCDGCFLNGRE 258
Query: 752 KQGLSPHGNVAFSKAGRSLHGDTEAPVNCSSCPGPP 787
+ P G+ R +G V C P PP
Sbjct: 259 HRSGEPVGSGDPCSHCRCANGS----VQCEPLPCPP 290
>gi|209571521 cysteine rich BMP regulator 2 isoform 2 [Homo sapiens]
Length = 814
Score = 253 bits (646), Expect = 6e-67
Identities = 141/388 (36%), Positives = 180/388 (46%), Gaps = 46/388 (11%)
Query: 360 LQGEVMGTPSSPRGPESPRLAAGPSPCWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKV 419
LQ V S P SP+ CW LG +RW C+ C C+DG C
Sbjct: 77 LQTRVRQLESCECHPASPQ-------CWGLGRAWPEGARWEPDACTACVCQDGAAHC--- 126
Query: 420 RCEAACSHPIPSRDGGCCPSCTGCFHSGVVRAEGDVFSPPNENCTVCVCLAGNVSCISPE 479
+H P C GC +G G+ FSP + CT C CL G ++C
Sbjct: 127 ---GPQAH---------LPHCRGCSQNGQTYGNGETFSP--DACTTCRCLEGTITCNQKP 172
Query: 480 CPSGPCQTPPQTDCCTCVPVRCYFHGRWYADGAVFSGGGDECTTCVCQNGEVECSFMPCP 539
CP GPC P CC C + G+ Y +G F + C C C V C + CP
Sbjct: 173 CPRGPCPEPGA--CCPHCKPGCDYEGQLYEEGVTFLSSSNPCLQCTCLRSRVRCMALKCP 230
Query: 540 ELACPREEWRLGPGQCCFTCQEPTPSTGCSLDDNGVEFPIGQIW-SPGDPCELCICQADG 598
CP E L PG CC TCQ GC+ + G + GQ W +PGDPC +C C +G
Sbjct: 231 PSPCP--EPVLRPGHCCPTCQ------GCT--EGGSHWEHGQEWTTPGDPCRICRC-LEG 279
Query: 599 SVSCKRTDCVDSCPHPIR-IPGQCCPDCSAGCTYTGRIFYNNETFPSVLDPCLSCICLLG 657
+ C++ +C CP+P R +PG CCP C GC GR + E S DPC C C G
Sbjct: 280 HIQCRQRECASLCPYPARPLPGTCCPVCD-GCFLNGREHRSGEPVGSG-DPCSHCRCANG 337
Query: 658 SVACSPVDC-PITCTYPFHPDGECCPVCRDCNYEGRKVANGQVFTLDDEP-CTRCTCQLG 715
SV C P+ C P+ C +P G+CCPVC C Y+G + + + F L + C RC+CQ G
Sbjct: 338 SVQCEPLPCPPVPCRHPGKIPGQCCPVCDGCEYQGHQYQSQETFRLQERGLCVRCSCQAG 397
Query: 716 EVSCEKVPCQRACADPALLPGDCCSSCP 743
EVSCE+ C P LP CP
Sbjct: 398 EVSCEEQECP---VTPCALPASGRQLCP 422
Score = 239 bits (611), Expect = 7e-63
Identities = 147/429 (34%), Positives = 194/429 (45%), Gaps = 69/429 (16%)
Query: 371 PRGPESPRLAAGPS---PCWHLGAMHESRSRWTEPG--CSQCWCEDGKVTCEKVRCEAA- 424
PRGP A P C + G ++E + C QC C +V C ++C +
Sbjct: 174 PRGPCPEPGACCPHCKPGCDYEGQLYEEGVTFLSSSNPCLQCTCLRSRVRCMALKCPPSP 233
Query: 425 CSHPIPSRDGGCCPSCTGCFHSGVVRAEGDVFSPPNENCTVCVCLAGNVSCISPECPSGP 484
C P+ R G CCP+C GC G G ++ P + C +C CL G++ C EC S
Sbjct: 234 CPEPV-LRPGHCCPTCQGCTEGGSHWEHGQEWTTPGDPCRICRCLEGHIQCRQRECAS-L 291
Query: 485 CQTPPQTDCCTCVPV--RCYFHGRWYADGAVFSGGGDECTTCVCQNGEVECSFMPCPELA 542
C P + TC PV C+ +GR + G G GD C+ C C NG V+C +PCP +
Sbjct: 292 CPYPARPLPGTCCPVCDGCFLNGREHRSGEPV-GSGDPCSHCRCANGSVQCEPLPCPPVP 350
Query: 543 CPREEWRLGPGQCCFTC-------------------------------------QEPTPS 565
C R ++ PGQCC C ++ P
Sbjct: 351 C-RHPGKI-PGQCCPVCDGCEYQGHQYQSQETFRLQERGLCVRCSCQAGEVSCEEQECPV 408
Query: 566 TGCSL-----------DDNGVEFPIGQIWSP-GDPCELCICQADGSVSCKRTDCVDS-CP 612
T C+L + +G EF G W P G PC C+CQ DG C C + C
Sbjct: 409 TPCALPASGRQLCPACELDGEEFAEGVQWEPDGRPCTACVCQ-DGVPKCGAVLCPPAPCQ 467
Query: 613 HPIRIPGQCCPDCSAGCTYTGRIFYNNETFPSVLDPCLSCICLLGSVACSPVDCP-ITCT 671
HP + PG CCP C + CTY +++ N + F PC +C C G+V CS VDCP TC
Sbjct: 468 HPTQPPGACCPSCDS-CTYHSQVYANGQNFTDADSPCHACHCQDGTVTCSLVDCPPTTCA 526
Query: 672 YPFHPDGECCPVCRDCNYEGRKVANGQVFTLDDEPCTRCTCQLGEVSCEKVPCQRA-CAD 730
P G+CCP C DC E +G+ F+ +PC C CQ G C+ PC RA CA
Sbjct: 527 RPQSGPGQCCPRCPDCILEEEVFVDGESFSHPRDPCQECRCQEGHAHCQPRPCPRAPCAH 586
Query: 731 PALLPGDCC 739
P LPG CC
Sbjct: 587 P--LPGTCC 593
Score = 230 bits (587), Expect = 4e-60
Identities = 137/363 (37%), Positives = 166/363 (45%), Gaps = 39/363 (10%)
Query: 398 RWTEPG--CSQCWCEDGKVTCEKVRCEAA-CSHPIPSRDGGCCPSCTGCFHSGVVRAEGD 454
+W G C+ C C+DG C V C A C HP G CCPSC C + V A G
Sbjct: 436 QWEPDGRPCTACVCQDGVPKCGAVLCPPAPCQHPTQP-PGACCPSCDSCTYHSQVYANGQ 494
Query: 455 VFSPPNENCTVCVCLAGNVSCISPECPSGPCQTPPQT--DCCTCVPVRCYFHGRWYADGA 512
F+ + C C C G V+C +CP C P CC P C + DG
Sbjct: 495 NFTDADSPCHACHCQDGTVTCSLVDCPPTTCARPQSGPGQCCPRCP-DCILEEEVFVDGE 553
Query: 513 VFSGGGDECTTCVCQNGEVECSFMPCPELACPREEWRLGPGQCCFTCQEPTPSTGCSLDD 572
FS D C C CQ G C PCP C PG CC P +GC+
Sbjct: 554 SFSHPRDPCQECRCQEGHAHCQPRPCPRAPCAHPL----PGTCC-----PNDCSGCAF-- 602
Query: 573 NGVEFPIGQIWS-PGDPCELCICQADGSVSCKRTDCVD-SCPHPIRIPGQCCPDCSA--- 627
G E+P G + P DPC LC C + G+V C CV CP P+ +PG+CCP C A
Sbjct: 603 GGKEYPSGADFPHPSDPCRLCRCLS-GNVQCLARRCVPLPCPEPVLLPGECCPQCPAAPA 661
Query: 628 --GCTYTGRIFYNN-ETFPSVLDPCLSCICLLGSVACSPVDCP-ITCTYPFHPDGECCPV 683
GC G + E F DPC C+CL GSV+C + CP C +P G CCP
Sbjct: 662 PAGCPRPGAAHARHQEYFSPPGDPCRRCLCLDGSVSCQRLPCPPAPCAHP--RQGPCCPS 719
Query: 684 CRDCNYEGRKVANGQVFTLDDEPCTRCTCQLGEVSCEKVPCQRACADPALLP----GDCC 739
C C Y+G++ A+G+ F C C C G VSCE +ACA PAL P GDCC
Sbjct: 720 CDGCLYQGKEFASGERFPSPTAACHLCLCWEGSVSCE----PKACA-PALCPFPARGDCC 774
Query: 740 SSC 742
C
Sbjct: 775 PDC 777
Score = 216 bits (550), Expect = 8e-56
Identities = 139/404 (34%), Positives = 172/404 (42%), Gaps = 37/404 (9%)
Query: 404 CSQCWCEDGKVTCEKVRCEAA-CSHP--IPSRDGGCCPSCTGCFHSGVVRAEGDVFSPPN 460
CS C C +G V CE + C C HP IP G CCP C GC + G + F
Sbjct: 329 CSHCRCANGSVQCEPLPCPPVPCRHPGKIP---GQCCPVCDGCEYQGHQYQSQETFRLQE 385
Query: 461 EN-CTVCVCLAGNVSCISPECPSGPCQTPPQ-TDCCTCVPVRCYFHGRWYADGAVFSGGG 518
C C C AG VSC ECP PC P C C G +A+G + G
Sbjct: 386 RGLCVRCSCQAGEVSCEEQECPVTPCALPASGRQLCPA----CELDGEEFAEGVQWEPDG 441
Query: 519 DECTTCVCQNGEVECSFMPCPELACPREEWRLGPGQCCFTCQEPTPSTGCSLDDNGVEFP 578
CT CVCQ+G +C + CP C PG CC +C T + +
Sbjct: 442 RPCTACVCQDGVPKCGAVLCPPAPCQHPTQP--PGACCPSCDSCTYHSQV--------YA 491
Query: 579 IGQIWSPGD-PCELCICQADGSVSCKRTDCVDS-CPHPIRIPGQCCPDCSAGCTYTGRIF 636
GQ ++ D PC C CQ DG+V+C DC + C P PGQCCP C C +F
Sbjct: 492 NGQNFTDADSPCHACHCQ-DGTVTCSLVDCPPTTCARPQSGPGQCCPRCP-DCILEEEVF 549
Query: 637 YNNETFPSVLDPCLSCICLLGSVACSPVDCP-ITCTYPFHPDGECCPV-CRDCNYEGRKV 694
+ E+F DPC C C G C P CP C +P G CCP C C + G++
Sbjct: 550 VDGESFSHPRDPCQECRCQEGHAHCQPRPCPRAPCAHPL--PGTCCPNDCSGCAFGGKEY 607
Query: 695 ANGQVFTLDDEPCTRCTCQLGEVSCEKVPC-QRACADPALLPGDCCSSCPDSLSPLEEKQ 753
+G F +PC C C G V C C C +P LLPG+CC CP + +P +
Sbjct: 608 PSGADFPHPSDPCRLCRCLSGNVQCLARRCVPLPCPEPVLLPGECCPQCPAAPAPAGCPR 667
Query: 754 GLSPHG--NVAFSKAG----RSLHGDTEAPVNCSSCPGPPTASP 791
+ H FS G R L D CP P A P
Sbjct: 668 PGAAHARHQEYFSPPGDPCRRCLCLDGSVSCQRLPCPPAPCAHP 711
Score = 213 bits (543), Expect = 5e-55
Identities = 198/690 (28%), Positives = 261/690 (37%), Gaps = 80/690 (11%)
Query: 62 GGGHCT----LPLCSFGC-------GSGICIAPNVCS-CQDGEQGATC---PETHGPCGE 106
G HC LP C GC G+G +P+ C+ C+ E TC P GPC E
Sbjct: 122 GAAHCGPQAHLPHCR-GCSQNGQTYGNGETFSPDACTTCRCLEGTITCNQKPCPRGPCPE 180
Query: 107 YGCDLTCNHGGCQEVARVCPVGFSMTETA----------VGIRCTDIDECVTSSCE---- 152
G GC ++ G + ++ +RC + +C S C
Sbjct: 181 PGACCPHCKPGCDYEGQLYEEGVTFLSSSNPCLQCTCLRSRVRCMAL-KCPPSPCPEPVL 239
Query: 153 --GHCVNT-----EGGFVCECGPGMQLSADR-HSCQDTD---ECLGTPCQQRCK---NSI 198
GHC T EGG E G D C+ + +C C C +
Sbjct: 240 RPGHCCPTCQGCTEGGSHWEHGQEWTTPGDPCRICRCLEGHIQCRQRECASLCPYPARPL 299
Query: 199 GSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCT---CRPGFRLR 255
C G L+G H + P C H C GS C C P
Sbjct: 300 PGTCCPVCDGCFLNGREHRSGEPVGSGDP-----CSH-CRCANGSVQCEPLPCPPVPCRH 353
Query: 256 ADRVSCEAFPKAVLAPSAILQPRQHPSKMLLLLPEAGRPALSPGHSPPSGAPGPPAGVRT 315
++ + P + Q Q+ S+ L E G + V
Sbjct: 354 PGKIPGQCCP---VCDGCEYQGHQYQSQETFRLQERGLCVRCSCQAGEVSCEEQECPVTP 410
Query: 316 TRLPSPTPRLPTSSPSAPVWLLSTLLATPV--PTASLLGNLRPPSLLQGEVMGTPSSPRG 373
LP+ +L + + P P + + P G V+ P+ +
Sbjct: 411 CALPASGRQLCPACELDGEEFAEGVQWEPDGRPCTACVCQDGVPKC--GAVLCPPAPCQH 468
Query: 374 PESPRLAAGPS--PCWHLGAMHESRSRWTEPG--CSQCWCEDGKVTCEKVRC-EAACSHP 428
P P A PS C + ++ + +T+ C C C+DG VTC V C C+ P
Sbjct: 469 PTQPPGACCPSCDSCTYHSQVYANGQNFTDADSPCHACHCQDGTVTCSLVDCPPTTCARP 528
Query: 429 IPSRDGGCCPSCTGCFHSGVVRAEGDVFSPPNENCTVCVCLAGNVSCISPECPSGPCQTP 488
S G CCP C C V +G+ FS P + C C C G+ C CP PC P
Sbjct: 529 -QSGPGQCCPRCPDCILEEEVFVDGESFSHPRDPCQECRCQEGHAHCQPRPCPRAPCAHP 587
Query: 489 PQTDCCTCVPVRCYFHGRWYADGAVFSGGGDECTTCVCQNGEVECSFMPCPELACPREEW 548
CC C F G+ Y GA F D C C C +G V+C C L CP E
Sbjct: 588 LPGTCCPNDCSGCAFGGKEYPSGADFPHPSDPCRLCRCLSGNVQCLARRCVPLPCP--EP 645
Query: 549 RLGPGQCCFTCQEPTPSTGCSLDDNGVEFPIGQIWSPGDPCELCICQADGSVSCKRTDCV 608
L PG+CC C GC PGDPC C+C DGSVSC+R C
Sbjct: 646 VLLPGECCPQCPAAPAPAGCPRPGAAHARHQEYFSPPGDPCRRCLC-LDGSVSCQRLPCP 704
Query: 609 DS-CPHPIRIPGQCCPDCSAGCTYTGRIFYNNETFPSVLDPCLSCICLLGSVACSPVDC- 666
+ C HP + G CCP C GC Y G+ F + E FPS C C+C GSV+C P C
Sbjct: 705 PAPCAHPRQ--GPCCPSCD-GCLYQGKEFASGERFPSPTAACHLCLCWEGSVSCEPKACA 761
Query: 667 PITCTYPFHPDGECCPVCRDCNYEGRKVAN 696
P C PF G+CCP DC+ EG + +
Sbjct: 762 PALC--PFPARGDCCP---DCDGEGHGIGS 786
Score = 155 bits (393), Expect = 1e-37
Identities = 99/303 (32%), Positives = 131/303 (43%), Gaps = 42/303 (13%)
Query: 490 QTDCCTCVPV--RCYFHGRWYADGAVFSGGGDECTTCVCQNGEVECSFMPCPELACPREE 547
Q + C C P +C+ GR + +GA + D CT CVCQ+G C P+ P
Sbjct: 83 QLESCECHPASPQCWGLGRAWPEGARWEP--DACTACVCQDGAAHCG----PQAHLPH-- 134
Query: 548 WRLGPGQCCFTCQEPTPSTGCSLDDNGVEFPIGQIWSPGDPCELCICQADGSVSCKRTDC 607
C+ GCS NG + G+ +SP D C C C +G+++C + C
Sbjct: 135 -----------CR------GCS--QNGQTYGNGETFSP-DACTTCRC-LEGTITCNQKPC 173
Query: 608 VDS-CPHPIRIPGQCCPDCSAGCTYTGRIFYNNETFPSVLDPCLSCICLLGSVACSPVDC 666
CP P G CCP C GC Y G+++ TF S +PCL C CL V C + C
Sbjct: 174 PRGPCPEP----GACCPHCKPGCDYEGQLYEEGVTFLSSSNPCLQCTCLRSRVRCMALKC 229
Query: 667 PIT-CTYPFHPDGECCPVCRDCNYEGRKVANGQVFTLDDEPCTRCTCQLGEVSCEKVPCQ 725
P + C P G CCP C+ C G +GQ +T +PC C C G + C + C
Sbjct: 230 PPSPCPEPVLRPGHCCPTCQGCTEGGSHWEHGQEWTTPGDPCRICRCLEGHIQCRQRECA 289
Query: 726 RACADPAL-LPGDCCSSCPDSLSPLEEKQGLSPHGNVAFSKAGRSLHGDTEAPVNCSSCP 784
C PA LPG CC C E + P G+ R +G V C P
Sbjct: 290 SLCPYPARPLPGTCCPVCDGCFLNGREHRSGEPVGSGDPCSHCRCANGS----VQCEPLP 345
Query: 785 GPP 787
PP
Sbjct: 346 CPP 348
>gi|108773804 Fraser syndrome 1 [Homo sapiens]
Length = 4011
Score = 145 bits (367), Expect = 1e-34
Identities = 120/423 (28%), Positives = 162/423 (38%), Gaps = 57/423 (13%)
Query: 361 QGEVMGTPSSPRGPESPRLAAGPSPCWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVR 420
+GEV+ ++ PE + P C H +HE + W CS C C G+V C
Sbjct: 72 KGEVLQIAANQCCPEC--VLRTPGSCHHEKKIHEHGTEWASSPCSVCSCNHGEVRCTPQP 129
Query: 421 C-EAACSHP----IPSRDGGCCPSCTG----CFHSGVVRAEGDVFSPPNENCTVCVCLAG 471
C +C H IP +G CCP C G C + G V +G+ + C C+C G
Sbjct: 130 CPPLSCGHQELAFIP--EGSCCPVCVGLGKPCSYEGHVFQDGEDWR--LSRCAKCLCRNG 185
Query: 472 NVSCISPECPSGPCQTP------PQTDCCTCVPVRCYFHGRWYADGAVFSGGGDECTTCV 525
C + +C C P C C C G+ Y G +S + CTTC+
Sbjct: 186 VAQCFTAQCQPLFCNQDETVVRVPGKCCPQCSARSCSAAGQVYEHGEQWS--ENACTTCI 243
Query: 526 CQNGEVECSFMPCPELACPREEWRL-GPGQCCFTCQEPTPSTGCSLDDNGVEFPIGQIWS 584
C GEV C C L C + + R GQCC C P S CS D GV ++W
Sbjct: 244 CDRGEVRCHKQACLPLRCGKGQSRARRHGQCCEECVSPAGS--CSYD--GVVRYQDEMWK 299
Query: 585 PGDPCELCICQADGSVSCKRTDCVD-SCPHP---IRIPGQCCPDC---SAGCTY--TGRI 635
G CE C+C G V+C+ +C C I + G+CCP+C + C Y TG
Sbjct: 300 -GSACEFCMCD-HGQVTCQTGECAKVECARDEELIHLDGKCCPECISRNGYCVYEETGEF 357
Query: 636 FYNNETFPSVL--------DPCLSCICLLGSVACSPVDCPITC---TYPFHPDGECCPVC 684
+N + + PC C C V C CP C T G+CCP C
Sbjct: 358 MSSNASEVKRIPEGEKWEDGPCKVCECRGAQVTCYEPSCP-PCPVGTLALEVKGQCCPDC 416
Query: 685 RDCNYEGRKVANGQVFTLDDEPCTRCTCQLGEVSCEKVPCQRACADPALLPGDCCSSCPD 744
+ + T P CQ + C +C G C +C
Sbjct: 417 TSVH------CHPDCLTCSQSPDHCDLCQDPTKLLQNGWCVHSCGLGFYQAGSLCLACQP 470
Query: 745 SLS 747
S
Sbjct: 471 QCS 473
Score = 138 bits (348), Expect = 2e-32
Identities = 109/409 (26%), Positives = 160/409 (39%), Gaps = 72/409 (17%)
Query: 386 CWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVRCEAACSHPIPSRDGG---------C 436
C + ++ + W C C C V C+ A C +P + + G C
Sbjct: 28 CVYQDSLLADATIWKPDSCQSCRCHGDIVICK----PAVCRNPQCAFEKGEVLQIAANQC 83
Query: 437 CPSCT-----GCFHSGVVRAEGDVFSPPNENCTVCVCLAGNVSCISPECPSGPCQTP--- 488
CP C C H + G ++ + C+VC C G V C CP C
Sbjct: 84 CPECVLRTPGSCHHEKKIHEHGTEWA--SSPCSVCSCNHGEVRCTPQPCPPLSCGHQELA 141
Query: 489 --PQTDCC-TCVPV--RCYFHGRWYADGAVFSGGGDECTTCVCQNGEVECSFMPCPELAC 543
P+ CC CV + C + G + DG + C C+C+NG +C C L C
Sbjct: 142 FIPEGSCCPVCVGLGKPCSYEGHVFQDGEDWR--LSRCAKCLCRNGVAQCFTAQCQPLFC 199
Query: 544 PREEWRLG-PGQCCFTCQEPTPSTGCSLDDNGVEFPIGQIWSPGDPCELCICQADGSVSC 602
++E + PG+CC C + CS G + G+ WS + C CIC G V C
Sbjct: 200 NQDETVVRVPGKCCPQCS----ARSCSA--AGQVYEHGEQWSE-NACTTCICDR-GEVRC 251
Query: 603 KRTDCV----DSCPHPIRIPGQCCPDC---SAGCTYTGRIFYNNETFPSVLDPCLSCICL 655
+ C+ R GQCC +C + C+Y G + Y +E + C C+C
Sbjct: 252 HKQACLPLRCGKGQSRARRHGQCCEECVSPAGSCSYDGVVRYQDEMWKG--SACEFCMCD 309
Query: 656 LGSVACSPVDC-PITCTYP---FHPDGECCPVCRD----CNYEG------------RKVA 695
G V C +C + C H DG+CCP C C YE +++
Sbjct: 310 HGQVTCQTGECAKVECARDEELIHLDGKCCPECISRNGYCVYEETGEFMSSNASEVKRIP 369
Query: 696 NGQVFTLDDEPCTRCTCQLGEVSCEKVPCQRACADPALL--PGDCCSSC 742
G+ + +D PC C C+ +V+C + C L G CC C
Sbjct: 370 EGEKW--EDGPCKVCECRGAQVTCYEPSCPPCPVGTLALEVKGQCCPDC 416
Score = 88.2 bits (217), Expect = 3e-17
Identities = 105/440 (23%), Positives = 144/440 (32%), Gaps = 65/440 (14%)
Query: 386 CWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVRC---EAACSHPIPSRDGGCCPSCT- 441
C G ++E +W+E C+ C C+ G+V C K C R G CC C
Sbjct: 221 CSAAGQVYEHGEQWSENACTTCICDRGEVRCHKQACLPLRCGKGQSRARRHGQCCEECVS 280
Query: 442 ---GCFHSGVVRAEGDVFSPPNENCTVCVCLAGNVSCISPECPSGPCQTPPQT-----DC 493
C + GVVR + +++ C C+C G V+C + EC C + C
Sbjct: 281 PAGSCSYDGVVRYQDEMWK--GSACEFCMCDHGQVTCQTGECAKVECARDEELIHLDGKC 338
Query: 494 C-TCVPVRCYFHGRWYADGAVFSGGGDE--------------CTTCVCQNGEVECSFMPC 538
C C+ Y + G S E C C C+ +V C C
Sbjct: 339 CPECISRNGYC--VYEETGEFMSSNASEVKRIPEGEKWEDGPCKVCECRGAQVTCYEPSC 396
Query: 539 PELACPREEWRLG-PGQCCFTCQEPTPSTGCSLDDNGVEFPIGQIWSPGDPCELCICQAD 597
P CP L GQCC C C SP D C+LC D
Sbjct: 397 P--PCPVGTLALEVKGQCCPDCTSVHCHPDCLTCSQ----------SP-DHCDLC---QD 440
Query: 598 GSVSCKRTDCVDSCPHPIRIPGQCCPDCSAGCTYTGRIFYNNETFPSVLDPCLSCICLLG 657
+ + CV SC G C C C+ + P +L C+ G
Sbjct: 441 PTKLLQNGWCVHSCGLGFYQAGSLCLACQPQCSTCTSGLECSSCQPPLLMRHGQCVPTCG 500
Query: 658 ----SVACSPVDCPITCTYPFHPDGECCPVCRD----CNYEGRKVANGQVFTLDDEPCTR 709
S C +C + P + C CRD G + + G+ F C+
Sbjct: 501 DGFYQDRHSCAVCHESCAGCWGPTEKHCLACRDPLHVLRDGGCESSCGKGFYNRQGTCSA 560
Query: 710 CTCQLGEVSCEKVPCQRACADPALLPGDCCSSCPDSLSPLEEKQGLSPHGNVAFSKAGRS 769
C C L G C S CP + H + A S
Sbjct: 561 CDQSCDSCGPSSPRCLTCTEKTVLHDGKCMSECPGGYYADATGRCKVCHNSCA------S 614
Query: 770 LHGDTEAPVNCSSCPGPPTA 789
G T P +C++C PP A
Sbjct: 615 CSGPT--PSHCTAC-SPPKA 631
Score = 42.7 bits (99), Expect = 0.002
Identities = 109/472 (23%), Positives = 158/472 (33%), Gaps = 130/472 (27%)
Query: 373 GPESPRLAAGPSPCWHLGAMHESRSRWTEPG------CSQCW-CEDGKVTCE---KVRCE 422
GP SPR C +H+ + PG +C C + +C C
Sbjct: 569 GPSSPRCLT----CTEKTVLHDGKCMSECPGGYYADATGRCKVCHNSCASCSGPTPSHC- 623
Query: 423 AACSHPIPSRDGGCCPSCTGCFHS--GVVRAEGD----VFSPPNENCTVC--------VC 468
ACS P R G C P C F+S GV +A P +CT C V
Sbjct: 624 TACSPPKALRQGHCLPRCGEGFYSDHGVCKACHSSCLACMGPAPSHCTGCKKPEEGLQVE 683
Query: 469 LAGNVSCISPEC-----------PSGPCQTPPQT----------DCCTCVPVRCYFHGRW 507
+V S EC +G C+ Q+ +C C P G+
Sbjct: 684 QLSDVGIPSGECLAQCRAHFYLESTGICEACHQSCFRCAGKSPHNCTDCGPSHVLLDGQC 743
Query: 508 YA---DGAVFSGGG-DEC-TTCVCQNGEVECSFMPC-PELACPREEWRLGPGQCCFTCQE 561
+ DG G EC TC +G +E + C P ++ L G C +C+E
Sbjct: 744 LSQCPDGYFHQEGSCTECHPTCRQCHGPLESDCISCYPHIS-------LTNGNCRTSCRE 796
Query: 562 PTPSTGCSLDDNGVEFPIGQIWSPGDPCELC-ICQAD----GSVSCKRTDCVDSCPHPIR 616
E + + D LC C AD GS+ C R C ++ H +
Sbjct: 797 --------------EQFLNLVGYCADCHHLCQHCAADLHNTGSI-CLR--CQNA--HYLL 837
Query: 617 IPGQCCPDCSAGCTYTGRIFYNNETFPSVLDPCLSCICLLGSVACSPVDCPITCTYPFHP 676
+ C PDC +G + C +C G +CS D + ++
Sbjct: 838 LGDHCVPDCPSG------YYAERGACKKCHSSCRTCQG-RGPFSCSSCDTNLVLSH---- 886
Query: 677 DGECCPVCRDCNYEGRKVANGQVFTLDDEPCTRCTCQLGEVSCEKVPCQRACADP--ALL 734
G C C +Y D+ C C G SC+ +C DP LL
Sbjct: 887 TGTCSTTCFPGHYLD-----------DNHVCQPCNTHCG--SCDSQASCTSCRDPNKVLL 933
Query: 735 PGDCCSSCPDSLSPLEEKQGLSPHGNVAFSKAGRSLHGDTEAPVNCSSCPGP 786
G+C + + +P + F S + E +CS+C GP
Sbjct: 934 FGEC------------QYESCAPQYYLDF-----STNTCKECDWSCSACSGP 968
Score = 34.3 bits (77), Expect = 0.57
Identities = 56/264 (21%), Positives = 85/264 (32%), Gaps = 48/264 (18%)
Query: 40 LGPHV---CLSGFGS--GCCPGWAPSMGGGHCTLPLCSFGCGSGICIA-PNVCS--CQDG 91
LG H C SG+ + G C S P C + + ++ CS C G
Sbjct: 838 LGDHCVPDCPSGYYAERGACKKCHSSCRTCQGRGPFSCSSCDTNLVLSHTGTCSTTCFPG 897
Query: 92 ---EQGATCPETHGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECVT 148
+ C + CG CD + C++ +V G E+ D
Sbjct: 898 HYLDDNHVCQPCNTHCGS--CDSQASCTSCRDPNKVLLFGECQYESCAPQYYLDFSTNTC 955
Query: 149 SSCEGHCVNTEGGFVCECGPGMQLSADRHSCQD---TDECLGT--------PCQQRCKNS 197
C+ C G +C M D + QD ++CL + C C
Sbjct: 956 KECDWSCSACSGPLKTDCLQCM----DGYVLQDGACVEQCLSSFYQDSGLCKCDSYCLQC 1011
Query: 198 IGSYKCS----------------CRTGFHLHGNRHSCVDVNE-CRRPLERRVCHHSCHNT 240
G ++C+ C G+ +H C + C + R CH H
Sbjct: 1012 QGPHECTRCKGPFLLLEAQCVQECGKGYFADHAKHKCTACPQGCLQCSHRDRCHLCDHGF 1071
Query: 241 -VGSFLCT--CRPGFRLRADRVSC 261
+ S LC C PGF + +C
Sbjct: 1072 FLKSGLCVYNCVPGFSVHTSNETC 1095
>gi|88758613 CD93 antigen precursor [Homo sapiens]
Length = 652
Score = 142 bits (359), Expect = 1e-33
Identities = 105/301 (34%), Positives = 135/301 (44%), Gaps = 38/301 (12%)
Query: 80 CIAPNVCSCQDGEQGATCPETHGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIR 139
C + N CS GATC G +G + TC CP G+ + + +
Sbjct: 300 CASRNPCSSSPCRGGATC-----VLGPHGKNYTCR----------CPQGYQLDSSQ--LD 342
Query: 140 CTDIDECVTSSCEGHCVNTEGGFVCECGPGMQLSA-DRHSCQDTDEC-LG-TPCQQRCKN 196
C D+DEC S C CVNT GGF CEC G + +CQD DEC LG +PC Q C N
Sbjct: 343 CVDVDECQDSPCAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQGCTN 402
Query: 197 SIGSYKCSCRTGFHLHG-NRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTCRPGFRLR 255
+ GS+ CSC G+ L G + C DV+EC P +C C NT GSF C C PG+ L
Sbjct: 403 TDGSFHCSCEEGYVLAGEDGTQCQDVDECVGP-GGPLCDSLCFNTQGSFHCGCLPGWVLA 461
Query: 256 ADRVSCEAFPKAVLAPSAILQPRQHPSKMLLLLPEAGRPALSPGHSPPSGAPGPPAGVRT 315
+ VSC P ++ PS K +P A SP G G P T
Sbjct: 462 PNGVSCTMGPVSLGPPSGPPDEEDKGEKEGSTVPRAATA------SPTRGPEGTPKATPT 515
Query: 316 TRLPSPTPRLPTSSPSAPVWLLSTLLATPVPTASLLGNLRPPSLLQGEVMGTPSSPRGPE 375
T PS + P + SAP+ +L+ P+ S G R PS+ P P G +
Sbjct: 516 TSRPSLSSDAPIT--SAPLKMLA-------PSGS-PGVWREPSIHHATAASGPQEPAGGD 565
Query: 376 S 376
S
Sbjct: 566 S 566
Score = 38.5 bits (88), Expect = 0.030
Identities = 111/468 (23%), Positives = 151/468 (32%), Gaps = 107/468 (22%)
Query: 451 AEGDVFSP--PNENCTVCVCLAGNVSCISPECPSGPCQ----TPPQTDCCTCVPVRCYFH 504
+EG SP P N VC P GP Q TP QT + V
Sbjct: 161 SEGPCGSPGSPGSNIEGFVCKFSFKGMCRPLALGGPGQVTYTTPFQTTSSSLEAVP---- 216
Query: 505 GRWYADGA-VFSGGGDECTTCVCQNGEVECSFMPCPELACPREEWRLGPGQCCFTCQEPT 563
+A A V G GD+ E + + C E A +W C +
Sbjct: 217 ---FASAANVACGEGDK--------DETQSHYFLCKEKAPDVFDWGSSGPLCV------S 259
Query: 564 PSTGCSLDDNGVEFPIGQIWSPGDPCELCICQA-----DGSVSC-KRTDCVDSCPHPIRI 617
P GC+ ++ G + GD LC C+ D V+C R C S P R
Sbjct: 260 PKYGCNFNNGGCH---QDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSS---PCR- 312
Query: 618 PGQCCPDCSAGCTYTGRIFYNNETFPSVLD----------PCLS-CICLLGSVACSPVDC 666
G C G YT R + S LD PC C+ G C
Sbjct: 313 GGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQECVNTPGGFRCE---- 368
Query: 667 PITCTYPFHPDGECCPVCRDCNYEGRKVANGQVFTLDDEPCTR-CTCQLGEVSCEKVPCQ 725
C + P G C+D + L PC + CT G C
Sbjct: 369 ---CWVGYEPGGPGEGACQDVDE----------CALGRSPCAQGCTNTDGSFHC------ 409
Query: 726 RACADPALLPGDCCSSCPDSLSPLEEKQGLSPHGNVAFSKAGRSLHGDTEAPVNCSSCPG 785
+C + +L G+ + C D ++E G P G + SL +T+ +C PG
Sbjct: 410 -SCEEGYVLAGEDGTQCQD----VDECVG--PGGPLC-----DSLCFNTQGSFHCGCLPG 457
Query: 786 PPTASPSRPVLHLLQLLLRTNLMKTQTLPTS---PAGAHGPHSLALGLTATFPGEPGASP 842
+L N + P S P+G +T P ASP
Sbjct: 458 ---------------WVLAPNGVSCTMGPVSLGPPSGPPDEEDKGEKEGSTVPRAATASP 502
Query: 843 RLSPGPSTPPGAPTLPLASPGAPQPPPVTPERSFSASGAQIVSRWPPL 890
P TP PT S + P P + + SG+ V R P +
Sbjct: 503 TRGP-EGTPKATPTTSRPSLSSDAPITSAPLKMLAPSGSPGVWREPSI 549
>gi|75709198 nephronectin [Homo sapiens]
Length = 565
Score = 137 bits (346), Expect = 4e-32
Identities = 99/326 (30%), Positives = 142/326 (43%), Gaps = 40/326 (12%)
Query: 44 VCLSGFGSGCCPGWAPSMGGGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGATCPETHGP 103
+C G CC GWA G C P+C C G CI PN C C G G TC +
Sbjct: 35 LCRYGGRIDCCWGWA-RQSWGQCQ-PVCQPRCKHGECIGPNKCKCHPGYAGKTCNQDLNE 92
Query: 104 CG------EYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECVTSSCEGHCVN 157
CG ++ C T C C G+ + C+ C ++C+ C
Sbjct: 93 CGLKPRPCKHRCMNTYGSYKC-----YCLNGYMLMPDG---SCSSALTCSMANCQYGCDV 144
Query: 158 TEGGFVCEC-GPGMQLSADRHSCQDTDEC----LGTPCQQRCKNSIGSYKCSCRTGFHLH 212
+G C+C PG+QL+ D +C D DEC P ++C N+ GSY C C GF L
Sbjct: 145 VKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLM 204
Query: 213 --GNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTCRPGFRLRADRVSCEAFPKAVLA 270
G ++ C D++EC + C+N GS+ C C+ G+ + D ++C PK ++
Sbjct: 205 YIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGY--QGDGLTCVYIPKVMIE 262
Query: 271 PSAILQPRQHPSKMLL-------LLPEAGR---PALSPGHSPPSGAPGPPAGVRTTRLPS 320
PS + + +L +P+ G P +P + PP P + T P
Sbjct: 263 PSGPIHVPKGNGTILKGDTGNNNWIPDVGSTWWPPKTP-YIPPIITNRPTSKPTTRPTPK 321
Query: 321 PTPRLPTSSPSAPVWLLSTLLATPVP 346
PTP +PT P P L T L TP+P
Sbjct: 322 PTP-IPTPPPPPP---LPTELRTPLP 343
>gi|10092639 cysteine-rich motor neuron 1 [Homo sapiens]
Length = 1036
Score = 135 bits (341), Expect = 1e-31
Identities = 106/386 (27%), Positives = 148/386 (38%), Gaps = 74/386 (19%)
Query: 404 CSQCWCEDGKVTCEKVRCEAACSHPIPSRDGGC----CPSCTGCFHSGVVRAEGDVFSPP 459
C C C C + C+ C + GC C C S + F
Sbjct: 527 CEICECRPRPKKCRPIICDKYCPLGLLKNKHGCDICRCKKCPELSCSKICPLG---FQQD 583
Query: 460 NENCTVCVCLAGNVSCISPECPSGPCQTPPQTDCCTCVPVRCYFHGR---WYADGAVFSG 516
+ C +C C + S P SG TC+ V + H W+
Sbjct: 584 SHGCLICKCREASASA-GPPILSG-----------TCLTVDGHHHKNEESWH-------- 623
Query: 517 GGDECTTCVCQNGEVECSFMPCPELACPREEWRLGPGQCCFTC------QEPTPSTGCSL 570
D C C C NG C+ + CP AC + PGQCC +C Q+P ST
Sbjct: 624 --DGCRECYCLNGREMCALITCPVPACGNPT--IHPGQCCPSCADDFVVQKPELSTPSIC 679
Query: 571 DDNGVEFPI-GQIWSPGDPCELCICQADGSVSCKRTDCVDS-CPHPIRIPGQCCPDCSAG 628
G E+ + G+ W+ D C C C + G V C+ C C +P R CCP C+
Sbjct: 680 HAPGGEYFVEGETWNI-DSCTQCTCHS-GRVLCETEVCPPLLCQNPSRTQDSCCPQCTDQ 737
Query: 629 ---------------CTYT-GRIFYNNETFPSVLDPCLSCICLLGSVACSPVDCP-ITCT 671
C G IF E++ D C SCIC+ ++C CP ++C
Sbjct: 738 PFRPSLSRNNSVPNYCKNDEGDIFLAAESWKP--DVCTSCICIDSVISCFSESCPSVSCE 795
Query: 672 YPFHPDGECCPVCRD--------CNYEGRKVANGQVFTLDDEPCTRCTCQLGEVSCEKVP 723
P G+CCP C + C++ G+ A+ + + LD CT C C G+ C V
Sbjct: 796 RPVLRKGQCCPYCIEDTIPKKVVCHFSGKAYADEERWDLDS--CTHCYCLQGQTLCSTVS 853
Query: 724 CQRA-CADPALLPGDCCSSCPDSLSP 748
C C +P + G CC CP+ P
Sbjct: 854 CPPLPCVEPINVEGSCCPMCPEMYVP 879
Score = 124 bits (311), Expect = 4e-28
Identities = 93/332 (28%), Positives = 128/332 (38%), Gaps = 66/332 (19%)
Query: 403 GCSQCWCED-GKVTCEKV---------------RCEAACSHPIPSRDGGCCPSCTGCFHS 446
GC C C+ +++C K+ +C A + P G C + G H
Sbjct: 558 GCDICRCKKCPELSCSKICPLGFQQDSHGCLICKCREASASAGPPILSGTCLTVDGHHHK 617
Query: 447 GVVRAEGDVFSPPNENCTVCVCLAGNVSCISPECPSGPCQTP---PQTDCCTCV------ 497
++ C C CL G C CP C P P C +C
Sbjct: 618 NE--------ESWHDGCRECYCLNGREMCALITCPVPACGNPTIHPGQCCPSCADDFVVQ 669
Query: 498 ------PVRCYFHG-RWYADGAVFSGGGDECTTCVCQNGEVECSFMPCPELACPREEWRL 550
P C+ G ++ +G ++ D CT C C +G V C CP L C
Sbjct: 670 KPELSTPSICHAPGGEYFVEGETWNI--DSCTQCTCHSGRVLCETEVCPPLLCQNPSRT- 726
Query: 551 GPGQCCFTCQE----PTPSTGCSL-----DDNGVEFPIGQIWSPGDPCELCICQADGSVS 601
CC C + P+ S S+ +D G F + W P D C CIC D +S
Sbjct: 727 -QDSCCPQCTDQPFRPSLSRNNSVPNYCKNDEGDIFLAAESWKP-DVCTSCIC-IDSVIS 783
Query: 602 CKRTDCVD-SCPHPIRIPGQCCPDC-------SAGCTYTGRIFYNNETFPSVLDPCLSCI 653
C C SC P+ GQCCP C C ++G+ + + E + LD C C
Sbjct: 784 CFSESCPSVSCERPVLRKGQCCPYCIEDTIPKKVVCHFSGKAYADEERWD--LDSCTHCY 841
Query: 654 CLLGSVACSPVDC-PITCTYPFHPDGECCPVC 684
CL G CS V C P+ C P + +G CCP+C
Sbjct: 842 CLQGQTLCSTVSCPPLPCVEPINVEGSCCPMC 873
Score = 117 bits (294), Expect = 4e-26
Identities = 107/430 (24%), Positives = 150/430 (34%), Gaps = 79/430 (18%)
Query: 383 PSPCWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVRCEAACSHPIPSRDGGCCPSC-- 440
P+ C+ G + RW E C+ C C +G+ C C C++P+ G CCP C
Sbjct: 400 PAGCYANGLILAHGDRWREDDCTFCQCVNGERHCVATVCGQTCTNPV-KVPGECCPVCEE 458
Query: 441 --------------TGCFHSGVVRAEGDVFSPPNENCTVCVCLAGNVSC------ISPEC 480
+ C +G G F + C C C+ C + C
Sbjct: 459 PTIITVDPPACGELSNCTLTGKDCING--FKRDHNGCRTCQCINTEELCSERKQGCTLNC 516
Query: 481 PSGPCQTPPQTDCCTCVP----VRCYFHGRWYADGAVFSGGGDECTTCVCQNGEVECSFM 536
P G + C C P R ++ G + + G C C C+ +C +
Sbjct: 517 PFGFLTDAQNCEICECRPRPKKCRPIICDKYCPLGLLKNKHG--CDICRCK----KCPEL 570
Query: 537 PCPELACPREEWRLGPGQCCFTCQEPTPS------TGCSLDDNGVEFPIGQIWSPGDPCE 590
C ++ CP + G C+E + S +G L +G + W G C
Sbjct: 571 SCSKI-CPLGFQQDSHGCLICKCREASASAGPPILSGTCLTVDGHHHKNEESWHDG--CR 627
Query: 591 LCICQADGSVSCKRTDC-VDSCPHPIRIPGQCCPDCSAGCTYT--------------GRI 635
C C +G C C V +C +P PGQCCP C+ G
Sbjct: 628 ECYC-LNGREMCALITCPVPACGNPTIHPGQCCPSCADDFVVQKPELSTPSICHAPGGEY 686
Query: 636 FYNNETFPSVLDPCLSCICLLGSVACSPVDC-PITCTYPFHPDGECCPVCRDCNYEGRKV 694
F ET+ +D C C C G V C C P+ C P CCP C D +
Sbjct: 687 FVEGETWN--IDSCTQCTCHSGRVLCETEVCPPLLCQNPSRTQDSCCPQCTDQPFRPSLS 744
Query: 695 ANGQV--FTLDDE-------------PCTRCTCQLGEVSCEKVPCQR-ACADPALLPGDC 738
N V + +DE CT C C +SC C +C P L G C
Sbjct: 745 RNNSVPNYCKNDEGDIFLAAESWKPDVCTSCICIDSVISCFSESCPSVSCERPVLRKGQC 804
Query: 739 CSSCPDSLSP 748
C C + P
Sbjct: 805 CPYCIEDTIP 814
Score = 109 bits (272), Expect = 1e-23
Identities = 79/274 (28%), Positives = 108/274 (39%), Gaps = 51/274 (18%)
Query: 390 GAMHESRSRWTEPGCSQCWCEDGKVTCEKVRCEA-ACSHPIPSRDGGCCPSCTGCF---- 444
G H++ W + GC +C+C +G+ C + C AC +P G CCPSC F
Sbjct: 613 GHHHKNEESWHD-GCRECYCLNGREMCALITCPVPACGNPT-IHPGQCCPSCADDFVVQK 670
Query: 445 -----------HSGVVRAEGDVFSPPNENCTVCVCLAGNVSCISPECPSGPCQTPPQT-- 491
G EG+ ++ ++CT C C +G V C + CP CQ P +T
Sbjct: 671 PELSTPSICHAPGGEYFVEGETWN--IDSCTQCTCHSGRVLCETEVCPPLLCQNPSRTQD 728
Query: 492 DCC---------------TCVPVRCYFHGRWYADGAVF----SGGGDECTTCVCQNGEVE 532
CC VP C +G +F S D CT+C+C + +
Sbjct: 729 SCCPQCTDQPFRPSLSRNNSVPNYCK-----NDEGDIFLAAESWKPDVCTSCICIDSVIS 783
Query: 533 CSFMPCPELACPREEWRLGPGQCCFTCQEPTPSTGCSLDDNGVEFPIGQIWSPGDPCELC 592
C CP ++C R R GQCC C E T +G + + W D C C
Sbjct: 784 CFSESCPSVSCERPVLR--KGQCCPYCIEDTIPKKVVCHFSGKAYADEERWDL-DSCTHC 840
Query: 593 ICQADGSVSCKRTDCVD-SCPHPIRIPGQCCPDC 625
C G C C C PI + G CCP C
Sbjct: 841 YC-LQGQTLCSTVSCPPLPCVEPINVEGSCCPMC 873
Score = 101 bits (251), Expect = 4e-21
Identities = 94/365 (25%), Positives = 129/365 (35%), Gaps = 104/365 (28%)
Query: 410 EDGKVTCEKVRCEAACSHPIPSRD---------GGCCPSCTGCFHSGVVRAEGDVFSPPN 460
E+ K C K RCE S P G CCP + C V +P
Sbjct: 168 EEEKPDCSKARCEVQFSPRCPEDSVLIEGYAPPGECCPLPSRC-----------VCNPAG 216
Query: 461 ENCTVCVCLAGNVSCISPECPSGPCQTPPQTDCCTCVPVRCYFHGRWYADGAVFSGGGDE 520
C VC GN++ + + P +CC + F G +
Sbjct: 217 --CLRKVCQPGNLNILVSKASGKP------GECCDLYECKPVF--------------GVD 254
Query: 521 CTTCVCQNGEVECSFMPCPELACPREEW----RLGPGQCCFTCQEPTPSTGCSLDDNGVE 576
C T VEC P + ACP + + RL CC T T C
Sbjct: 255 CRT-------VECP--PVQQTACPPDSYETQVRLTADGCC------TLPTRCECLSGLCG 299
Query: 577 FPIGQIWSPGDPCELCICQADGSVSCKRTDCVDSCPHPIRIPGQCCP------DCSAGCT 630
FP+ ++ S + + DG+ PG+CC D C
Sbjct: 300 FPVCEVGST----PRIVSRGDGT------------------PGKCCDVFECVNDTKPACV 337
Query: 631 YTGRIFYNNETFPSVLDPCLSCICLLGSVACSPVDC-PITCTYPFHPDGECCPVCRD--- 686
+ +Y+ + F +D C C C G C C I C + P+GECCPVC D
Sbjct: 338 FNNVEYYDGDMFR--MDNCRFCRCQGGVAICFTAQCGEINCERYYVPEGECCPVCEDPVY 395
Query: 687 -------CNYEGRKVANGQVFTLDDEPCTRCTCQLGEVSCEKVPCQRACADPALLPGDCC 739
C G +A+G + DD CT C C GE C C + C +P +PG+CC
Sbjct: 396 PFNNPAGCYANGLILAHGDRWREDD--CTFCQCVNGERHCVATVCGQTCTNPVKVPGECC 453
Query: 740 SSCPD 744
C +
Sbjct: 454 PVCEE 458
Score = 63.2 bits (152), Expect = 1e-09
Identities = 83/353 (23%), Positives = 119/353 (33%), Gaps = 75/353 (21%)
Query: 456 FSPPNENCTV-CVCLAGNVSCISPECPSGPCQTPPQTDCCTCVPVRCYFHGRWYADGAVF 514
F P NEN C + G C + S P + P Q C + +
Sbjct: 122 FKPCNENLIAGCNIINGKCECNTIRTCSNPFEFPSQDMCLSALKR--------------I 167
Query: 515 SGGGDECTTCVCQNGEVECSFMP-CPELACPREEWRLGPGQCCFTCQEPTPSTGCSLDDN 573
+C+ C E F P CPE + E + PG+CC P PS C +
Sbjct: 168 EEEKPDCSKARC-----EVQFSPRCPEDSVLIEGYA-PPGECC-----PLPSR-CVCNPA 215
Query: 574 GVEFPIGQIWS-----------PGDPCELCICQADGSVSCKRTDCVD----SCPHPIRIP 618
G + Q + PG+ C+L C+ V C+ +C +CP P
Sbjct: 216 GCLRKVCQPGNLNILVSKASGKPGECCDLYECKPVFGVDCRTVECPPVQQTACP-PDSYE 274
Query: 619 GQCCPDCSAGCTYTGRIFYNNETFPSVLDPCLSCICLLGSVACSPVDCPITCTYPFHPDG 678
Q CT R CLS +C G C P + G
Sbjct: 275 TQVRLTADGCCTLPTRC------------ECLSGLC--GFPVCEVGSTPRIVSRGDGTPG 320
Query: 679 ECCPVCR-------DCNYEGRKVANGQVFTLDDEPCTRCTCQLGEVSCEKVPCQRACADP 731
+CC V C + + +G +F +D+ C C CQ G C C +
Sbjct: 321 KCCDVFECVNDTKPACVFNNVEYYDGDMFRMDN--CRFCRCQGGVAICFTAQCGEINCER 378
Query: 732 ALLP-GDCCSSCPDSLSPLEEKQGLSPHGNVAFSKAGRSLHGDTEAPVNCSSC 783
+P G+CC C D + P G +G + HGD +C+ C
Sbjct: 379 YYVPEGECCPVCEDPVYPFNNPAGCYANGLIL-------AHGDRWREDDCTFC 424
Score = 47.0 bits (110), Expect = 9e-05
Identities = 26/91 (28%), Positives = 36/91 (39%), Gaps = 15/91 (16%)
Query: 386 CWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVRC-EAACSHPIPSRDGGCCPSCTGCF 444
C G + RW C+ C+C G+ C V C C PI + +G CCP C +
Sbjct: 819 CHFSGKAYADEERWDLDSCTHCYCLQGQTLCSTVSCPPLPCVEPI-NVEGSCCPMCPEMY 877
Query: 445 -------------HSGVVRAEGDVFSPPNEN 462
H G V E ++ P+EN
Sbjct: 878 VPEPTNIPIEKTNHRGEVDLEVPLWPTPSEN 908
>gi|34734064 fibulin 1 isoform B precursor [Homo sapiens]
Length = 601
Score = 129 bits (324), Expect = 1e-29
Identities = 79/210 (37%), Positives = 113/210 (53%), Gaps = 21/210 (10%)
Query: 75 CGSGICIAPNVCSCQDGEQGATCPETHGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTET 134
CG+G + + SC+D ++ + H ++ C T C+ + C GF +
Sbjct: 248 CGTGYELTEDN-SCKDIDECES--GIHNCLPDFICQNTLGSFRCRPKLQ-CKSGF--IQD 301
Query: 135 AVGIRCTDIDECVTSSCE---GH-CVNTEGGFVCE-----CGPGMQLSADRHSCQDTDEC 185
A+G C DI+EC++ S GH C+NTEG + C+ CG G L+ + C D DEC
Sbjct: 302 ALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC 360
Query: 186 L--GTPCQQ--RCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTV 241
PC + RC NS GS++C C+TG++ G CVDVNEC+R R+C H C NT+
Sbjct: 361 APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQR-YPGRLCGHKCENTL 419
Query: 242 GSFLCTCRPGFRLRADRVSCEAFPKAVLAP 271
GS+LC+C GFRL D SCE + +P
Sbjct: 420 GSYLCSCSVGFRLSVDGRSCEDINECSSSP 449
Score = 117 bits (292), Expect = 7e-26
Identities = 70/232 (30%), Positives = 104/232 (44%), Gaps = 30/232 (12%)
Query: 43 HVCLSGFGSGCCPGWAPSMGGGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGATCPETHG 102
H C++ GS C P+ CG G + C D ++ C
Sbjct: 323 HTCINTEGSYTCQKNVPN--------------CGRGYHLNEEGTRCVDVDE---CAPPAE 365
Query: 103 PCGE-YGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECVTSS---CEGHCVNT 158
PCG+ + C + C+ C G+ + C D++EC C C NT
Sbjct: 366 PCGKGHRCVNSPGSFRCE-----CKTGYYFD--GISRMCVDVNECQRYPGRLCGHKCENT 418
Query: 159 EGGFVCECGPGMQLSADRHSCQDTDECLGTPCQQRCKNSIGSYKCSCRTGFHLHG-NRHS 217
G ++C C G +LS D SC+D +EC +PC Q C N GSY+C CR G+ L + +
Sbjct: 419 LGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVT 478
Query: 218 CVDVNECRRPLERRVCHHSCHNTVGSFLCTC-RPGFRLRADRVSCEAFPKAV 268
C D++EC P +C + C N GSF C+C G+RL + +C+ + V
Sbjct: 479 CEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECV 530
Score = 96.7 bits (239), Expect = 9e-20
Identities = 68/211 (32%), Positives = 87/211 (41%), Gaps = 36/211 (17%)
Query: 53 CCPGWAPSMGGGHCTLPLCSFGCG----------SGICIAPNVCSCQDGEQ-GATCPETH 101
C P P G C SF C S +C+ N C G G C T
Sbjct: 360 CAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENT- 418
Query: 102 GPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECVTSSCEGHCVNTEGG 161
G Y C C VGF ++ G C DI+EC +S C C N G
Sbjct: 419 --LGSYLCS--------------CSVGFRLSVD--GRSCEDINECSSSPCSQECANVYGS 460
Query: 162 FVCECGPGMQLS-ADRHSCQDTDECL----GTPCQQRCKNSIGSYKCSC-RTGFHLHGNR 215
+ C C G QLS D +C+D DEC G C RC N GS++CSC +G+ L N
Sbjct: 461 YQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNG 520
Query: 216 HSCVDVNECRRPLERRVCHHSCHNTVGSFLC 246
+C D++EC + + +C N G F C
Sbjct: 521 RNCQDIDECVTGIHNCSINETCFNIQGGFRC 551
Score = 59.7 bits (143), Expect = 1e-08
Identities = 43/134 (32%), Positives = 63/134 (47%), Gaps = 11/134 (8%)
Query: 136 VGIRCTDIDE--CVTSSCEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDECLGT-PCQQ 192
VG +C + CV S G + + G + E +++ ++ D C G PC+Q
Sbjct: 132 VGYQCGQVFRACCVKSQETG---DLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQ 188
Query: 193 RCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLC----TC 248
+C+++ CSC G+ L + SC DVNEC SC NTVGSF C +C
Sbjct: 189 QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSC 248
Query: 249 RPGFRLRADRVSCE 262
G+ L D SC+
Sbjct: 249 GTGYELTEDN-SCK 261
>gi|34734068 fibulin 1 isoform A precursor [Homo sapiens]
Length = 566
Score = 129 bits (324), Expect = 1e-29
Identities = 79/210 (37%), Positives = 113/210 (53%), Gaps = 21/210 (10%)
Query: 75 CGSGICIAPNVCSCQDGEQGATCPETHGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTET 134
CG+G + + SC+D ++ + H ++ C T C+ + C GF +
Sbjct: 248 CGTGYELTEDN-SCKDIDECES--GIHNCLPDFICQNTLGSFRCRPKLQ-CKSGF--IQD 301
Query: 135 AVGIRCTDIDECVTSSCE---GH-CVNTEGGFVCE-----CGPGMQLSADRHSCQDTDEC 185
A+G C DI+EC++ S GH C+NTEG + C+ CG G L+ + C D DEC
Sbjct: 302 ALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC 360
Query: 186 L--GTPCQQ--RCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTV 241
PC + RC NS GS++C C+TG++ G CVDVNEC+R R+C H C NT+
Sbjct: 361 APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQR-YPGRLCGHKCENTL 419
Query: 242 GSFLCTCRPGFRLRADRVSCEAFPKAVLAP 271
GS+LC+C GFRL D SCE + +P
Sbjct: 420 GSYLCSCSVGFRLSVDGRSCEDINECSSSP 449
Score = 117 bits (292), Expect = 7e-26
Identities = 70/232 (30%), Positives = 104/232 (44%), Gaps = 30/232 (12%)
Query: 43 HVCLSGFGSGCCPGWAPSMGGGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGATCPETHG 102
H C++ GS C P+ CG G + C D ++ C
Sbjct: 323 HTCINTEGSYTCQKNVPN--------------CGRGYHLNEEGTRCVDVDE---CAPPAE 365
Query: 103 PCGE-YGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECVTSS---CEGHCVNT 158
PCG+ + C + C+ C G+ + C D++EC C C NT
Sbjct: 366 PCGKGHRCVNSPGSFRCE-----CKTGYYFD--GISRMCVDVNECQRYPGRLCGHKCENT 418
Query: 159 EGGFVCECGPGMQLSADRHSCQDTDECLGTPCQQRCKNSIGSYKCSCRTGFHLHG-NRHS 217
G ++C C G +LS D SC+D +EC +PC Q C N GSY+C CR G+ L + +
Sbjct: 419 LGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVT 478
Query: 218 CVDVNECRRPLERRVCHHSCHNTVGSFLCTC-RPGFRLRADRVSCEAFPKAV 268
C D++EC P +C + C N GSF C+C G+RL + +C+ + V
Sbjct: 479 CEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECV 530
Score = 96.7 bits (239), Expect = 9e-20
Identities = 68/211 (32%), Positives = 87/211 (41%), Gaps = 36/211 (17%)
Query: 53 CCPGWAPSMGGGHCTLPLCSFGCG----------SGICIAPNVCSCQDGEQ-GATCPETH 101
C P P G C SF C S +C+ N C G G C T
Sbjct: 360 CAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENT- 418
Query: 102 GPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECVTSSCEGHCVNTEGG 161
G Y C C VGF ++ G C DI+EC +S C C N G
Sbjct: 419 --LGSYLCS--------------CSVGFRLSVD--GRSCEDINECSSSPCSQECANVYGS 460
Query: 162 FVCECGPGMQLS-ADRHSCQDTDECL----GTPCQQRCKNSIGSYKCSC-RTGFHLHGNR 215
+ C C G QLS D +C+D DEC G C RC N GS++CSC +G+ L N
Sbjct: 461 YQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNG 520
Query: 216 HSCVDVNECRRPLERRVCHHSCHNTVGSFLC 246
+C D++EC + + +C N G F C
Sbjct: 521 RNCQDIDECVTGIHNCSINETCFNIQGGFRC 551
Score = 59.7 bits (143), Expect = 1e-08
Identities = 43/134 (32%), Positives = 63/134 (47%), Gaps = 11/134 (8%)
Query: 136 VGIRCTDIDE--CVTSSCEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDECLGT-PCQQ 192
VG +C + CV S G + + G + E +++ ++ D C G PC+Q
Sbjct: 132 VGYQCGQVFRACCVKSQETG---DLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQ 188
Query: 193 RCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLC----TC 248
+C+++ CSC G+ L + SC DVNEC SC NTVGSF C +C
Sbjct: 189 QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSC 248
Query: 249 RPGFRLRADRVSCE 262
G+ L D SC+
Sbjct: 249 GTGYELTEDN-SCK 261
>gi|34734066 fibulin 1 isoform D [Homo sapiens]
Length = 703
Score = 129 bits (324), Expect = 1e-29
Identities = 79/210 (37%), Positives = 113/210 (53%), Gaps = 21/210 (10%)
Query: 75 CGSGICIAPNVCSCQDGEQGATCPETHGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTET 134
CG+G + + SC+D ++ + H ++ C T C+ + C GF +
Sbjct: 248 CGTGYELTEDN-SCKDIDECES--GIHNCLPDFICQNTLGSFRCRPKLQ-CKSGF--IQD 301
Query: 135 AVGIRCTDIDECVTSSCE---GH-CVNTEGGFVCE-----CGPGMQLSADRHSCQDTDEC 185
A+G C DI+EC++ S GH C+NTEG + C+ CG G L+ + C D DEC
Sbjct: 302 ALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC 360
Query: 186 L--GTPCQQ--RCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTV 241
PC + RC NS GS++C C+TG++ G CVDVNEC+R R+C H C NT+
Sbjct: 361 APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQR-YPGRLCGHKCENTL 419
Query: 242 GSFLCTCRPGFRLRADRVSCEAFPKAVLAP 271
GS+LC+C GFRL D SCE + +P
Sbjct: 420 GSYLCSCSVGFRLSVDGRSCEDINECSSSP 449
Score = 117 bits (292), Expect = 7e-26
Identities = 70/232 (30%), Positives = 104/232 (44%), Gaps = 30/232 (12%)
Query: 43 HVCLSGFGSGCCPGWAPSMGGGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGATCPETHG 102
H C++ GS C P+ CG G + C D ++ C
Sbjct: 323 HTCINTEGSYTCQKNVPN--------------CGRGYHLNEEGTRCVDVDE---CAPPAE 365
Query: 103 PCGE-YGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECVTSS---CEGHCVNT 158
PCG+ + C + C+ C G+ + C D++EC C C NT
Sbjct: 366 PCGKGHRCVNSPGSFRCE-----CKTGYYFD--GISRMCVDVNECQRYPGRLCGHKCENT 418
Query: 159 EGGFVCECGPGMQLSADRHSCQDTDECLGTPCQQRCKNSIGSYKCSCRTGFHLHG-NRHS 217
G ++C C G +LS D SC+D +EC +PC Q C N GSY+C CR G+ L + +
Sbjct: 419 LGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVT 478
Query: 218 CVDVNECRRPLERRVCHHSCHNTVGSFLCTC-RPGFRLRADRVSCEAFPKAV 268
C D++EC P +C + C N GSF C+C G+RL + +C+ + V
Sbjct: 479 CEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECV 530
Score = 96.7 bits (239), Expect = 9e-20
Identities = 68/211 (32%), Positives = 87/211 (41%), Gaps = 36/211 (17%)
Query: 53 CCPGWAPSMGGGHCTLPLCSFGCG----------SGICIAPNVCSCQDGEQ-GATCPETH 101
C P P G C SF C S +C+ N C G G C T
Sbjct: 360 CAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENT- 418
Query: 102 GPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECVTSSCEGHCVNTEGG 161
G Y C C VGF ++ G C DI+EC +S C C N G
Sbjct: 419 --LGSYLCS--------------CSVGFRLSVD--GRSCEDINECSSSPCSQECANVYGS 460
Query: 162 FVCECGPGMQLS-ADRHSCQDTDECL----GTPCQQRCKNSIGSYKCSC-RTGFHLHGNR 215
+ C C G QLS D +C+D DEC G C RC N GS++CSC +G+ L N
Sbjct: 461 YQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNG 520
Query: 216 HSCVDVNECRRPLERRVCHHSCHNTVGSFLC 246
+C D++EC + + +C N G F C
Sbjct: 521 RNCQDIDECVTGIHNCSINETCFNIQGGFRC 551
Score = 59.7 bits (143), Expect = 1e-08
Identities = 43/134 (32%), Positives = 63/134 (47%), Gaps = 11/134 (8%)
Query: 136 VGIRCTDIDE--CVTSSCEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDECLGT-PCQQ 192
VG +C + CV S G + + G + E +++ ++ D C G PC+Q
Sbjct: 132 VGYQCGQVFRACCVKSQETG---DLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQ 188
Query: 193 RCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLC----TC 248
+C+++ CSC G+ L + SC DVNEC SC NTVGSF C +C
Sbjct: 189 QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSC 248
Query: 249 RPGFRLRADRVSCE 262
G+ L D SC+
Sbjct: 249 GTGYELTEDN-SCK 261
>gi|34734062 fibulin 1 isoform C precursor [Homo sapiens]
Length = 683
Score = 129 bits (324), Expect = 1e-29
Identities = 79/210 (37%), Positives = 113/210 (53%), Gaps = 21/210 (10%)
Query: 75 CGSGICIAPNVCSCQDGEQGATCPETHGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTET 134
CG+G + + SC+D ++ + H ++ C T C+ + C GF +
Sbjct: 248 CGTGYELTEDN-SCKDIDECES--GIHNCLPDFICQNTLGSFRCRPKLQ-CKSGF--IQD 301
Query: 135 AVGIRCTDIDECVTSSCE---GH-CVNTEGGFVCE-----CGPGMQLSADRHSCQDTDEC 185
A+G C DI+EC++ S GH C+NTEG + C+ CG G L+ + C D DEC
Sbjct: 302 ALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC 360
Query: 186 L--GTPCQQ--RCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTV 241
PC + RC NS GS++C C+TG++ G CVDVNEC+R R+C H C NT+
Sbjct: 361 APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQR-YPGRLCGHKCENTL 419
Query: 242 GSFLCTCRPGFRLRADRVSCEAFPKAVLAP 271
GS+LC+C GFRL D SCE + +P
Sbjct: 420 GSYLCSCSVGFRLSVDGRSCEDINECSSSP 449
Score = 117 bits (292), Expect = 7e-26
Identities = 70/232 (30%), Positives = 104/232 (44%), Gaps = 30/232 (12%)
Query: 43 HVCLSGFGSGCCPGWAPSMGGGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGATCPETHG 102
H C++ GS C P+ CG G + C D ++ C
Sbjct: 323 HTCINTEGSYTCQKNVPN--------------CGRGYHLNEEGTRCVDVDE---CAPPAE 365
Query: 103 PCGE-YGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECVTSS---CEGHCVNT 158
PCG+ + C + C+ C G+ + C D++EC C C NT
Sbjct: 366 PCGKGHRCVNSPGSFRCE-----CKTGYYFD--GISRMCVDVNECQRYPGRLCGHKCENT 418
Query: 159 EGGFVCECGPGMQLSADRHSCQDTDECLGTPCQQRCKNSIGSYKCSCRTGFHLHG-NRHS 217
G ++C C G +LS D SC+D +EC +PC Q C N GSY+C CR G+ L + +
Sbjct: 419 LGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVT 478
Query: 218 CVDVNECRRPLERRVCHHSCHNTVGSFLCTC-RPGFRLRADRVSCEAFPKAV 268
C D++EC P +C + C N GSF C+C G+RL + +C+ + V
Sbjct: 479 CEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECV 530
Score = 100 bits (248), Expect = 8e-21
Identities = 74/233 (31%), Positives = 95/233 (40%), Gaps = 40/233 (17%)
Query: 53 CCPGWAPSMGGGHCTLPLCSFGCG----------SGICIAPNVCSCQDGEQ-GATCPETH 101
C P P G C SF C S +C+ N C G G C T
Sbjct: 360 CAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENT- 418
Query: 102 GPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECVTSSCEGHCVNTEGG 161
G Y C C VGF ++ G C DI+EC +S C C N G
Sbjct: 419 --LGSYLCS--------------CSVGFRLSVD--GRSCEDINECSSSPCSQECANVYGS 460
Query: 162 FVCECGPGMQLS-ADRHSCQDTDECL----GTPCQQRCKNSIGSYKCSC-RTGFHLHGNR 215
+ C C G QLS D +C+D DEC G C RC N GS++CSC +G+ L N
Sbjct: 461 YQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNG 520
Query: 216 HSCVDVNECRRPLERRVCHHSCHNTVGSFLC---TCRPGFRLRADRVSCEAFP 265
+C D++EC + + +C N G F C C +R R+ CE P
Sbjct: 521 RNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYR-RSAATRCERLP 572
Score = 59.7 bits (143), Expect = 1e-08
Identities = 43/134 (32%), Positives = 63/134 (47%), Gaps = 11/134 (8%)
Query: 136 VGIRCTDIDE--CVTSSCEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDECLGT-PCQQ 192
VG +C + CV S G + + G + E +++ ++ D C G PC+Q
Sbjct: 132 VGYQCGQVFRACCVKSQETG---DLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQ 188
Query: 193 RCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLC----TC 248
+C+++ CSC G+ L + SC DVNEC SC NTVGSF C +C
Sbjct: 189 QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSC 248
Query: 249 RPGFRLRADRVSCE 262
G+ L D SC+
Sbjct: 249 GTGYELTEDN-SCK 261
>gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens]
Length = 988
Score = 128 bits (322), Expect = 2e-29
Identities = 84/242 (34%), Positives = 111/242 (45%), Gaps = 38/242 (15%)
Query: 43 HVCLS----GFGSGCCPGWAPSMGGGHCTLPLCSFGCGSGICIAPNVC--SCQDGEQGAT 96
H+C G C PG+ + CTL C++G G C SC+D + G T
Sbjct: 175 HICRETPKGGVACDCRPGFDLAQNQKDCTLT-CNYGNGG--------CQHSCEDTDTGPT 225
Query: 97 CPETHGPCGEYGCDLTC------NHGGCQEVAR--------VCPVGFSMTETAVGIRCTD 142
C H + TC N+GGC + CPVGF++ G C D
Sbjct: 226 CG-CHQKYALHSDGRTCIETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPD--GKTCKD 282
Query: 143 IDECVTSS--CEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDEC-LGTPCQQRCKNSIG 199
I+EC+ ++ C+ C NT G F C C G +L D +CQD DEC C C NS G
Sbjct: 283 INECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFERTCDHICINSPG 342
Query: 200 SYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTCRPGFRLRADRV 259
S++C C G+ L+G H C DV+EC + C C NT GS+ C C PG RL +
Sbjct: 343 SFQCLCHRGYILYGTTH-CGDVDECS--MSNGSCDQGCVNTKGSYECVCPPGRRLHWNGK 399
Query: 260 SC 261
C
Sbjct: 400 DC 401
Score = 98.2 bits (243), Expect = 3e-20
Identities = 62/212 (29%), Positives = 89/212 (41%), Gaps = 17/212 (8%)
Query: 52 GCCPGWAPSMGGGHCTLPLCSFGCGSGICIAPNVCSC-QDGEQGATCPETHGPCGEYGCD 110
GC +MG C C SG ++ N +C +G C ++GC
Sbjct: 127 GCQQICVNAMGSYECQ-------CHSGFFLSDNQHTCIHRSNEGMNCMNK-----DHGCA 174
Query: 111 LTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECVTSSCEGHCVNTEGGFVCECGPGM 170
C VA C GF + + CT C+ C +T+ G C C
Sbjct: 175 HICRETPKGGVACDCRPGFDLAQNQKD--CTLTCNYGNGGCQHSCEDTDTGPTCGCHQKY 232
Query: 171 QLSADRHSCQDTDECLGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLER 230
L +D +C +T C + CK++ +CSC GF L + +C D+NEC +
Sbjct: 233 ALHSDGRTCIETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECL--VNN 290
Query: 231 RVCHHSCHNTVGSFLCTCRPGFRLRADRVSCE 262
C H C NTVGSF C CR G++L D +C+
Sbjct: 291 GGCDHFCRNTVGSFECGCRKGYKLLTDERTCQ 322
Score = 83.2 bits (204), Expect = 1e-15
Identities = 44/128 (34%), Positives = 64/128 (50%), Gaps = 12/128 (9%)
Query: 142 DIDECVTSSCEGH----CVNTEGGFVCECGPGMQLSADRHSCQDTDEC----LGTPCQQR 193
D+DEC + + H C NT + C C PG + + C+D DEC C
Sbjct: 33 DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYK--GEGKQCEDIDECENDYYNGGCVHE 90
Query: 194 CKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTCRPGFR 253
C N G+Y+C+C GF L + H+C+DV+EC+ C C N +GS+ C C GF
Sbjct: 91 CINIPGNYRCTCFDGFMLAHDGHNCLDVDECQD--NNGGCQQICVNAMGSYECQCHSGFF 148
Query: 254 LRADRVSC 261
L ++ +C
Sbjct: 149 LSDNQHTC 156
Score = 68.6 bits (166), Expect = 3e-11
Identities = 54/195 (27%), Positives = 79/195 (40%), Gaps = 31/195 (15%)
Query: 86 CSCQDGE--QGATCPETHGPCGEYGCDLTCNHGGC-QEVARV-------CPVGFSMTETA 135
C C+ G +G C + C+ +GGC E + C GF +
Sbjct: 59 CLCKPGYKGEGKQCEDIDE------CENDYYNGGCVHECINIPGNYRCTCFDGFMLAHD- 111
Query: 136 VGIRCTDIDECVTSS--CEGHCVNTEGGFVCECGPGMQLSADRHSC----QDTDECLGTP 189
G C D+DEC ++ C+ CVN G + C+C G LS ++H+C + C+
Sbjct: 112 -GHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKD 170
Query: 190 --CQQRCKNS-IGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLC 246
C C+ + G C CR GF L N+ C C C HSC +T C
Sbjct: 171 HGCAHICRETPKGGVACDCRPGFDLAQNQKDC--TLTCN--YGNGGCQHSCEDTDTGPTC 226
Query: 247 TCRPGFRLRADRVSC 261
C + L +D +C
Sbjct: 227 GCHQKYALHSDGRTC 241
Score = 57.4 bits (137), Expect = 6e-08
Identities = 38/128 (29%), Positives = 54/128 (42%), Gaps = 13/128 (10%)
Query: 86 CSCQDGEQGATCPETHGPCGEYGCDLTCNH---GGCQEVARVCPVGFSMTETAVGIRCTD 142
C C+ G + T T E + TC+H +C G+ + T C D
Sbjct: 306 CGCRKGYKLLTDERTCQDIDECSFERTCDHICINSPGSFQCLCHRGYILYGTT---HCGD 362
Query: 143 IDECVTS--SCEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDECLGTP-----CQQRCK 195
+DEC S SC+ CVNT+G + C C PG +L + C +T +CL Q C
Sbjct: 363 VDECSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQLSCS 422
Query: 196 NSIGSYKC 203
+ G C
Sbjct: 423 KAGGVESC 430
>gi|13124888 epidermal growth factor-like protein 6 precursor [Homo
sapiens]
Length = 553
Score = 128 bits (321), Expect = 3e-29
Identities = 78/236 (33%), Positives = 103/236 (43%), Gaps = 21/236 (8%)
Query: 42 PHVCLSGFGSGCCPGWAPSMGGGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGATCPETH 101
P VC G CC GW + G C GC G C+ PN C C G G TC +
Sbjct: 38 PGVCHYGTKLACCYGWRRNSKG--VCEATCEPGCKFGECVGPNKCRCFPGYTGKTCSQDV 95
Query: 102 GPCG--EYGCDLTC--NHGGCQEVARVCPVGFSMTETAVGIRCTDIDECVTSSCEGHCVN 157
CG C C HG + C G + A C + C +C+ C +
Sbjct: 96 NECGMKPRPCQHRCVNTHGSYK---CFCLSGHMLMPDAT---CVNSRTCAMINCQYSCED 149
Query: 158 TEGGFVCEC-GPGMQLSADRHSCQDTDECLG----TPCQQRCKNSIGSYKCSCRTGFHLH 212
TE G C C G++L+ + C D DEC P +RC N+ GSY C C GF L
Sbjct: 150 TEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQ 209
Query: 213 --GNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTCRPGFRLRADRVSCEAFPK 266
R+ C+D+NEC H +C NT GSF C C+ G+ + + + C A P+
Sbjct: 210 YISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGY--KGNGLRCSAIPE 263
>gi|24430141 fibrillin 1 precursor [Homo sapiens]
Length = 2871
Score = 125 bits (315), Expect = 1e-28
Identities = 145/552 (26%), Positives = 204/552 (36%), Gaps = 109/552 (19%)
Query: 41 GPHVCLSGFGSGCCPGWAPSMGGGHCTLPLCSFGCGSGICIAPNVCSCQDGE-------- 92
GP+VC S + + CCPGW GG C +P+C CG G C PN+C+C G+
Sbjct: 55 GPNVCGSRYNAYCCPGWKTLPGGNQCIVPICRHSCGDGFCSRPNMCTCPSGQIAPSCGSR 114
Query: 93 ----------QGATCPETH---------GPCGEYGCDLTCNHGG-CQEVAR-VCPVGFSM 131
G +C + H CG+ C+ C +GG C R C GF+
Sbjct: 115 SIQHCNIRCMNGGSCSDDHCLCQKGYIGTHCGQPVCESGCLNGGRCVAPNRCACTYGFTG 174
Query: 132 TETAVGIRCTDIDECVTSS-CEGH----------CVNTEG---GFVCE--------CGPG 169
+ R +++ C+G C T G G CE C G
Sbjct: 175 PQCERDYRTGPCFTVISNQMCQGQLSGIVCTKTLCCATVGRAWGHPCEMCPAQPHPCRRG 234
Query: 170 MQLSADRHSCQDTDECLGTP--CQQ-RCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRR 226
+ +CQD DEC P CQ C N++GS++C C G L+ C D++EC
Sbjct: 235 FIPNIRTGACQDVDECQAIPGLCQGGNCINTVGSFECKCPAGHKLNEVSQKCEDIDECST 294
Query: 227 PLERRVCHHS-CHNTVGSFLCTCRPGFRLRADRVSC-EAFP----KAVLAPSAILQPRQH 280
+C C NTV S+ C C PGF D C + P A+ Q Q
Sbjct: 295 I--PGICEGGECTNTVSSYFCKCPPGFYTSPDGTRCIDVRPGYCYTALTNGRCSNQLPQS 352
Query: 281 PSKMLLLLPEAGRPALSPGHS-PPSGAPGPPAGVRTTRLPSPTPRLPTSSPSAPVWLLST 339
+KM +AGR SPG + P P +R T + +P P P +
Sbjct: 353 ITKMQCCC-DAGR-CWSPGVTVAPEMCP-----IRATEDFNKLCSVPMVIPGRPEY---- 401
Query: 340 LLATPVPTASLLGNLRPPSLLQGEVMGTPSSPRGPESPRLAAGPSPCWHLGAMHESRSRW 399
P P + PP L P P P P++ P +L E
Sbjct: 402 ---PPPPLGPI-----PPVL--------PVPPGFPPGPQIPVPRPPVEYLYPSREPPR-- 443
Query: 400 TEPGCSQCWCEDGKVTCEKVRCEAACSHPIPSRDGGCCPSCTGCFHSGVVRAEGDVFSPP 459
P +C+ + C+ RC IP+ G C C F + DV
Sbjct: 444 VLPVNVTDYCQLVRYLCQNGRC-------IPT-PGSCRCECNKGFQLDLRGECIDVDECE 495
Query: 460 NENCT--VCVCLAGNVSCISPECPSGPCQTPPQTDCCTCVPVRCYFHGRWYADGAVFSGG 517
C C+ G+ +C +C +G T +T+C C +GR +G +
Sbjct: 496 KNPCAGGECINNQGSYTC---QCRAGYQSTLTRTECRDI--DECLQNGRICNNGRCINTD 550
Query: 518 GDECTTCVCQNG 529
G CVC G
Sbjct: 551 GS--FHCVCNAG 560
Score = 118 bits (296), Expect = 2e-26
Identities = 81/232 (34%), Positives = 105/232 (45%), Gaps = 35/232 (15%)
Query: 53 CCPGWAPSMGGGHCT-LPLCSFGCGSGICIAPNV-----CSCQDG----EQGATCPETHG 102
C G+ P + G C L C+ I N CSC G E G +C +
Sbjct: 2429 CKTGYTPDITGTSCVDLNECNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRSCKDLD- 2487
Query: 103 PCG--EYGCDLTCNH--GG--CQEVARVCPVGFSMTETAVGIRCTDIDECVTS----SCE 152
C ++ C C + GG C+ CP GF+ T+ C D +EC + +
Sbjct: 2488 ECATKQHNCQFLCVNTIGGFTCK-----CPPGFTQHHTS----CIDNNECTSDINLCGSK 2538
Query: 153 GHCVNTEGGFVCECGPGMQLSADRHSCQDTDECLGTP-CQQRCKNSIGSYKCSCRTGFHL 211
G C NT G F CEC G L SC+D DEC G CQ C+N IG Y+CSC G+
Sbjct: 2539 GICQNTPGSFTCECQRGFSLDQTGSSCEDVDECEGNHRCQHGCQNIIGGYRCSCPQGYLQ 2598
Query: 212 HGNRHSCVDVNECRRPLERRVC-HHSCHNTVGSFLCTCRPGFRLRADRVSCE 262
H + CVD NEC L +C SCHNT+GS+ C C GF+ C+
Sbjct: 2599 HYQWNQCVDENEC---LSAHICGGASCHNTLGSYKCMCPAGFQYEQFSGGCQ 2647
Score = 115 bits (288), Expect = 2e-25
Identities = 83/249 (33%), Positives = 108/249 (43%), Gaps = 35/249 (14%)
Query: 40 LGPHVCLSG--------FGSGCCPGWAPSMGGGHCT-LPLCSFG---CGS-GICI---AP 83
L P++CLSG F C G++ G CT + C G CG +C
Sbjct: 1286 LNPNICLSGTCENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGS 1345
Query: 84 NVCSCQDG--EQGATCPETHGPCGEYGCDLTCNHGGCQEVAR----VCPVGFSMTETAVG 137
CSC G G C + C G + H C+ +C G+ T G
Sbjct: 1346 FKCSCSPGWIGDGIKCTDLD-ECSN-GTHMCSQHADCKNTMGSYRCLCKEGY----TGDG 1399
Query: 138 IRCTDIDEC---VTSSCEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDEC-LGTPCQ-Q 192
CTD+DEC + G C+N GG+ CEC G SAD +C+D DEC L C
Sbjct: 1400 FTCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDECSLPNICVFG 1459
Query: 193 RCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTCRPGF 252
C N G ++C C G+ L + +C DVNEC P +C NT GS++C C P F
Sbjct: 1460 TCHNLPGLFRCECEIGYELDRSGGNCTDVNECLDP--TTCISGNCVNTPGSYICDCPPDF 1517
Query: 253 RLRADRVSC 261
L RV C
Sbjct: 1518 ELNPTRVGC 1526
Score = 110 bits (276), Expect = 5e-24
Identities = 75/208 (36%), Positives = 98/208 (47%), Gaps = 23/208 (11%)
Query: 64 GHCTLPLCSFGC--GSGICIAPNVCSCQDGEQGATCPET--HGPCGEYGCDLTCNHGGCQ 119
G C + SF C SG + +C D ++ P+ G C D C C
Sbjct: 1042 GKCRNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLCGRGQCVNTPGDFECK---CD 1098
Query: 120 EVARVCPVGFSMTETAVGIRCTDIDECVTSS--CEGH-CVNTEGGFVCECGPGMQLSADR 176
E GF M + C DIDEC C G C NTEG + CEC PG QLS +
Sbjct: 1099 EGYES---GFMMMKN-----CMDIDECQRDPLLCRGGVCHNTEGSYRCECPPGHQLSPNI 1150
Query: 177 HSCQDTDEC--LGTPCQQ-RCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVC 233
+C D +EC C RC N IG Y+C+C G+H +R CVD++EC + C
Sbjct: 1151 SACIDINECELSAHLCPNGRCVNLIGKYQCACNPGYHSTPDRLFCVDIDEC--SIMNGGC 1208
Query: 234 HHSCHNTVGSFLCTCRPGFRLRADRVSC 261
C N+ GS+ C+C+PGF L D+ SC
Sbjct: 1209 ETFCTNSEGSYECSCQPGFALMPDQRSC 1236
Score = 107 bits (266), Expect = 7e-23
Identities = 88/286 (30%), Positives = 117/286 (40%), Gaps = 32/286 (11%)
Query: 17 PGAPARGYTGRKPPGHFAAERRRLGPHVCLSG--------FGSGCCPGWAPSMGGGHCT- 67
PG + T KP E + + P +C G F C G+A +CT
Sbjct: 1012 PGFATKEITNGKPFFKDINECKMI-PSLCTHGKCRNTIGSFKCRCDSGFALDSEERNCTD 1070
Query: 68 LPLCSFG---CGSGICI---APNVCSCQDG-EQGATCPETHGPCGEYGCD-LTCNHGGCQ 119
+ C CG G C+ C C +G E G + E D L C G C
Sbjct: 1071 IDECRISPDLCGRGQCVNTPGDFECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGGVCH 1130
Query: 120 EVARV----CPVGFSMTETAVGIRCTDIDECVTSS--C-EGHCVNTEGGFVCECGPGMQL 172
CP G ++ C DI+EC S+ C G CVN G + C C PG
Sbjct: 1131 NTEGSYRCECPPGHQLSPNISA--CIDINECELSAHLCPNGRCVNLIGKYQCACNPGYHS 1188
Query: 173 SADRHSCQDTDEC--LGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLER 230
+ DR C D DEC + C+ C NS GSY+CSC+ GF L ++ SC D++EC
Sbjct: 1189 TPDRLFCVDIDECSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTDIDECED--NP 1246
Query: 231 RVCHHS-CHNTVGSFLCTCRPGFRLRADRVSCEAFPKAVLAPSAIL 275
+C C N G + C C GF D +C + L P+ L
Sbjct: 1247 NICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNICL 1292
Score = 106 bits (264), Expect = 1e-22
Identities = 67/218 (30%), Positives = 99/218 (45%), Gaps = 29/218 (13%)
Query: 61 MGGGHCTLPLCSFGCGSGICIAPNVCSCQDG---EQGATCPETHGPCGEYGCDLTCNHGG 117
+G C P+ F + + ++ CQ+G ++ A C T G Y CD
Sbjct: 1786 VGSFRCECPV-GFFYNDKLLVCEDIDECQNGPVCQRNAECINT---AGSYRCD------- 1834
Query: 118 CQEVARVCPVGFSMTETAVGIRCTDIDEC--VTSSCE-GHCVNTEGGFVCECGPGMQLSA 174
C G+ T T +C D +EC + + C G C++T G F C C G + +
Sbjct: 1835 -------CKPGYRFTSTG---QCNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTND 1884
Query: 175 DRHSCQDTDECLGTPCQQ-RCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVC 233
D+ C D +EC C C+N+IGS+ C C GF L N + C+DV+EC
Sbjct: 1885 DQTMCLDINECERDACGNGTCRNTIGSFNCRCNHGFILSHN-NDCIDVDECASGNGNLCR 1943
Query: 234 HHSCHNTVGSFLCTCRPGFRLRADRVSCEAFPKAVLAP 271
+ C NTVGSF C C G+ + D +C + +L P
Sbjct: 1944 NGQCINTVGSFQCQCNEGYEVAPDGRTCVDINECLLEP 1981
Score = 102 bits (255), Expect = 1e-21
Identities = 69/206 (33%), Positives = 89/206 (43%), Gaps = 29/206 (14%)
Query: 80 CIAPNVCS---C--QDGEQGATCPETHGPCGEYGCDLT-------CNHGGCQEVAR---- 123
C P+VC C DG CP + G D C +G C+ V
Sbjct: 2131 CKEPDVCKHGQCINTDGSYRCECPFGYILAGNECVDTDECSVGNPCGNGTCKNVIGGFEC 2190
Query: 124 VCPVGFSMTETAVGIRCTDIDECVTSS--CEGHCVNTEGGFVCECGPGMQLSADRHSCQD 181
C GF E + C DI+EC + C CVNT G + C+C G L DR C+D
Sbjct: 2191 TCEEGF---EPGPMMTCEDINECAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCKD 2247
Query: 182 TDECLG-----TPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHS 236
DEC T Q CKN IG+Y C C G+ + CVD NEC+ + +C +
Sbjct: 2248 EDECEEGKHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCVDENECQ--TKPGICENG 2305
Query: 237 -CHNTVGSFLCTCRPGFRLRADRVSC 261
C NT GS+ C C GF ++ C
Sbjct: 2306 RCLNTRGSYTCECNDGFTASPNQDEC 2331
Score = 102 bits (254), Expect = 2e-21
Identities = 77/237 (32%), Positives = 106/237 (44%), Gaps = 27/237 (11%)
Query: 42 PHVCLSGFGSG--------CCPGWAPSMGGGHCT---LPLCSFGCGSGICIAPNVCSCQD 90
P +C G S C G++ S G C + C G C +P S
Sbjct: 2021 PEICALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPK--SRNH 2078
Query: 91 GEQGATCPETHGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECVTSS 150
+Q C G+ C+L C + ++CP G + D+DEC
Sbjct: 2079 SKQECCCALKGEGWGD-PCEL-CPTEPDEAFRQICPYGSGII-VGPDDSAVDMDECKEPD 2135
Query: 151 C--EGHCVNTEGGFVCECGPGMQLSADRHSCQDTDEC-LGTPCQQ-RCKNSIGSYKCSCR 206
G C+NT+G + CEC G L+ + C DTDEC +G PC CKN IG ++C+C
Sbjct: 2136 VCKHGQCINTDGSYRCECPFGYILAGNE--CVDTDECSVGNPCGNGTCKNVIGGFECTCE 2193
Query: 207 TGFHLHGNRHSCVDVNEC-RRPLERRVCHHSCHNTVGSFLCTCRPGFRLRADRVSCE 262
GF G +C D+NEC + PL +C C NT GS+ C C G+ LR DR C+
Sbjct: 2194 EGFE-PGPMMTCEDINECAQNPL---LCAFRCVNTYGSYECKCPVGYVLREDRRMCK 2246
Score = 99.8 bits (247), Expect = 1e-20
Identities = 59/165 (35%), Positives = 83/165 (50%), Gaps = 19/165 (11%)
Query: 97 CPETHGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECVTSS-CE--G 153
C E G C C C+ CPVGF + + C DIDEC C+
Sbjct: 1770 CREIPGVCENGVCINMVGSFRCE-----CPVGFFYNDKL--LVCEDIDECQNGPVCQRNA 1822
Query: 154 HCVNTEGGFVCECGPGMQLSADRHSCQDTDECLGTP--CQQ-RCKNSIGSYKCSCRTGFH 210
C+NT G + C+C PG + ++ C D +EC P C +C +++GS+ C C TGF
Sbjct: 1823 ECINTAGSYRCDCKPGYRFTSTGQ-CNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFK 1881
Query: 211 LHGNRHSCVDVNECRRPLERRVC-HHSCHNTVGSFLCTCRPGFRL 254
+ ++ C+D+NEC ER C + +C NT+GSF C C GF L
Sbjct: 1882 TNDDQTMCLDINEC----ERDACGNGTCRNTIGSFNCRCNHGFIL 1922
Score = 99.0 bits (245), Expect = 2e-20
Identities = 62/191 (32%), Positives = 81/191 (42%), Gaps = 16/191 (8%)
Query: 66 CTLPLCSFGCGSGICIAPNVCSCQDGEQGATCPETHGPCGEYG-CDLTCNHGGCQEVARV 124
C + F C + SC D + C CG G C T C+
Sbjct: 2500 CVNTIGGFTCKCPPGFTQHHTSCIDNNE---CTSDINLCGSKGICQNTPGSFTCE----- 2551
Query: 125 CPVGFSMTETAVGIRCTDIDECVTSS-CEGHCVNTEGGFVCECGPGMQLSADRHSCQDTD 183
C GFS+ +T G C D+DEC + C+ C N GG+ C C G + C D +
Sbjct: 2552 CQRGFSLDQT--GSSCEDVDECEGNHRCQHGCQNIIGGYRCSCPQGYLQHYQWNQCVDEN 2609
Query: 184 ECLGTPC--QQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTV 241
ECL C N++GSYKC C GF C D+NEC + C + C NT
Sbjct: 2610 ECLSAHICGGASCHNTLGSYKCMCPAGFQYEQFSGGCQDINECGS--AQAPCSYGCSNTE 2667
Query: 242 GSFLCTCRPGF 252
G +LC C PG+
Sbjct: 2668 GGYLCGCPPGY 2678
Score = 98.2 bits (243), Expect = 3e-20
Identities = 84/246 (34%), Positives = 109/246 (44%), Gaps = 40/246 (16%)
Query: 45 CLSGFGS---GCCPGWAPSMGGGHCT-LPLCSFG---CGSGICIAPNV-----CSCQDGE 92
C + GS C PG+A CT + C C G C N+ C C DG
Sbjct: 1212 CTNSEGSYECSCQPGFALMPDQRSCTDIDECEDNPNICDGGQCT--NIPGEYRCLCYDGF 1269
Query: 93 QGATCPETHGPCGEYGCDLT---CNHGGCQEVARV----CPVGFSMTETAVGIRCTDIDE 145
+ +T E CDL C G C+ C +G+S + G CTDI+E
Sbjct: 1270 MASEDMKTCVDVNE--CDLNPNICLSGTCENTKGSFICHCDMGYSGKKGKTG--CTDINE 1325
Query: 146 CVTSS--CEGH--CVNTEGGFVCECGPGMQLSADRHSCQDTDECL-GTP-CQQR--CKNS 197
C + C H C NT G F C C PG D C D DEC GT C Q CKN+
Sbjct: 1326 CEIGAHNCGKHAVCTNTAGSFKCSCSPGW--IGDGIKCTDLDECSNGTHMCSQHADCKNT 1383
Query: 198 IGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHS-CHNTVGSFLCTCRPGFRLRA 256
+GSY+C C+ G+ G+ +C D++EC L +C + C N G + C C GF A
Sbjct: 1384 MGSYRCLCKEGYT--GDGFTCTDLDECSENLN--LCGNGQCLNAPGGYRCECDMGFVPSA 1439
Query: 257 DRVSCE 262
D +CE
Sbjct: 1440 DGKACE 1445
Score = 97.4 bits (241), Expect = 5e-20
Identities = 71/235 (30%), Positives = 90/235 (38%), Gaps = 77/235 (32%)
Query: 75 CGSGICIAPNVCSCQDGEQ----GATCPETHGPC----GEYGCDLTCNHGGCQEVARVCP 126
C G ++PN+ +C D + CP +G C G+Y C CN G
Sbjct: 1140 CPPGHQLSPNISACIDINECELSAHLCP--NGRCVNLIGKYQC--ACNPG---------- 1185
Query: 127 VGFSMTETAVGIRCTDIDEC--VTSSCEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDE 184
T + C DIDEC + CE C N+EG + C C PG L D+ SC D DE
Sbjct: 1186 ----YHSTPDRLFCVDIDECSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTDIDE 1241
Query: 185 CLGTP--CQQ-RCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVC-------- 233
C P C +C N G Y+C C GF + +CVDVNEC L +C
Sbjct: 1242 CEDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNEC--DLNPNICLSGTCENT 1299
Query: 234 ------------------------------------HHSCHNTVGSFLCTCRPGF 252
H C NT GSF C+C PG+
Sbjct: 1300 KGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGW 1354
Score = 97.1 bits (240), Expect = 7e-20
Identities = 63/192 (32%), Positives = 89/192 (46%), Gaps = 33/192 (17%)
Query: 79 ICIAPNVCSCQDGEQGATCPETHGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVGI 138
+C+ N C +D TC T G + C CNHG F ++
Sbjct: 1888 MCLDINECE-RDACGNGTCRNT---IGSFNC--RCNHG------------FILSHNN--- 1926
Query: 139 RCTDIDECVTSS---CE-GHCVNTEGGFVCECGPGMQLSADRHSCQDTDECLGTP---CQ 191
C D+DEC + + C G C+NT G F C+C G +++ D +C D +ECL P
Sbjct: 1927 DCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINECLLEPRKCAP 1986
Query: 192 QRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCH-HSCHNTVGSFLCTCRP 250
C+N GSY+C C G+ L + C D++EC E +C +C NT GSF C C
Sbjct: 1987 GTCQNLDGSYRCICPPGYSLQNEK--CEDIDECVE--EPEICALGTCSNTEGSFKCLCPE 2042
Query: 251 GFRLRADRVSCE 262
GF L + C+
Sbjct: 2043 GFSLSSSGRRCQ 2054
Score = 93.2 bits (230), Expect = 1e-18
Identities = 51/128 (39%), Positives = 65/128 (50%), Gaps = 6/128 (4%)
Query: 138 IRCTDIDECVTSSCE-GHCVNTEGGFVCECGPGMQLSADRHSCQDTDECLGTPCQQ-RCK 195
+ TD + V C+ G C+ T G CEC G QL R C D DEC PC C
Sbjct: 447 VNVTDYCQLVRYLCQNGRCIPTPGSCRCECNKGFQLDL-RGECIDVDECEKNPCAGGECI 505
Query: 196 NSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHS-CHNTVGSFLCTCRPGFRL 254
N+ GSY C CR G+ R C D++EC + R+C++ C NT GSF C C GF +
Sbjct: 506 NNQGSYTCQCRAGYQSTLTRTECRDIDECLQ--NGRICNNGRCINTDGSFHCVCNAGFHV 563
Query: 255 RADRVSCE 262
D +CE
Sbjct: 564 TRDGKNCE 571
Score = 91.3 bits (225), Expect = 4e-18
Identities = 50/126 (39%), Positives = 63/126 (50%), Gaps = 8/126 (6%)
Query: 142 DIDEC--VTSSCE-GHCVNTEGGFVCECGPGMQLSADRHSCQDTDECLGTPCQQR---CK 195
DIDEC + CE G C+N G F CEC G + C+D DEC P QR C
Sbjct: 1766 DIDECREIPGVCENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNAECI 1825
Query: 196 NSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTCRPGFRLR 255
N+ GSY+C C+ G+ C D NEC+ + H C +TVGSF C C GF+
Sbjct: 1826 NTAGSYRCDCKPGYRFTSTGQ-CNDRNECQE-IPNICSHGQCIDTVGSFYCLCHTGFKTN 1883
Query: 256 ADRVSC 261
D+ C
Sbjct: 1884 DDQTMC 1889
Score = 86.7 bits (213), Expect = 1e-16
Identities = 72/283 (25%), Positives = 98/283 (34%), Gaps = 94/283 (33%)
Query: 75 CGSGICIAPNV---CSCQDG----EQGATCPETHGPCGEYGCDLTCNHGGC----QEVAR 123
C +G CI + C C G G C + E C +G C
Sbjct: 541 CNNGRCINTDGSFHCVCNAGFHVTRDGKNCEDMD----ECSIRNMCLNGMCINEDGSFKC 596
Query: 124 VCPVGFSMTETAVGIRCTDIDECVTSSC--EGHCVNTEGGFVCECGPGMQLSADRH---- 177
+C GF + G C DI+EC T G CVNT+G + CEC PG+ + D
Sbjct: 597 ICKPGFQLASD--GRYCKDINECETPGICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVD 654
Query: 178 -----------------------------SCQDTDECLGTPCQQR--------------- 193
C T+ G PCQ
Sbjct: 655 THMRSTCYGGYKRGQCIKPLFGAVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALCSSG 714
Query: 194 ------------------------CKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLE 229
C+N G+YKC C +G+ + +CVD+NEC L
Sbjct: 715 PGMTSAGSDINECALDPDICPNGICENLRGTYKCICNSGYEVDSTGKNCVDINEC--VLN 772
Query: 230 RRVCHH-SCHNTVGSFLCTCRPGFRLRADRVSCEAFPKAVLAP 271
+C + C NT GSF+CTC GF + D +CE + +P
Sbjct: 773 SLLCDNGQCRNTPGSFVCTCPKGFIYKPDLKTCEDIDECESSP 815
Score = 85.5 bits (210), Expect = 2e-16
Identities = 62/192 (32%), Positives = 81/192 (42%), Gaps = 23/192 (11%)
Query: 75 CGSGICI---APNVCSCQDGEQGATCPETHGPCGEYGCDLT----CNHGGCQEVAR---- 123
C G CI C C+ G Q T C + L CN+G C
Sbjct: 499 CAGGECINNQGSYTCQCRAGYQSTL---TRTECRDIDECLQNGRICNNGRCINTDGSFHC 555
Query: 124 VCPVGFSMTETAVGIRCTDIDEC-VTSSC-EGHCVNTEGGFVCECGPGMQLSADRHSCQD 181
VC GF +T G C D+DEC + + C G C+N +G F C C PG QL++D C+D
Sbjct: 556 VCNAGFHVTRD--GKNCEDMDECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKD 613
Query: 182 TDEC--LGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDV---NECRRPLERRVCHHS 236
+EC G RC N+ GSY+C C G + + CVD + C +R C
Sbjct: 614 INECETPGICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKP 673
Query: 237 CHNTVGSFLCTC 248
V C C
Sbjct: 674 LFGAVTKSECCC 685
Score = 83.2 bits (204), Expect = 1e-15
Identities = 68/232 (29%), Positives = 93/232 (40%), Gaps = 57/232 (24%)
Query: 42 PHVCLSG--------FGSGCCPGWAPSMGGGHCT----LPLCSFGCGSGICIAP------ 83
P +C++G + C PG A + G C C G G CI P
Sbjct: 620 PGICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKPLFGAVT 679
Query: 84 -NVCSCQD-----GEQGATCPETHGPCGEY-------------GCDLT--------CNHG 116
+ C C GE CP + EY G D+ C +G
Sbjct: 680 KSECCCASTEYAFGEPCQPCPAQNS--AEYQALCSSGPGMTSAGSDINECALDPDICPNG 737
Query: 117 GCQEVAR----VCPVGFSMTETAVGIRCTDIDECVTSS--CE-GHCVNTEGGFVCECGPG 169
C+ + +C G+ + T G C DI+ECV +S C+ G C NT G FVC C G
Sbjct: 738 ICENLRGTYKCICNSGYEVDST--GKNCVDINECVLNSLLCDNGQCRNTPGSFVCTCPKG 795
Query: 170 MQLSADRHSCQDTDECLGTPC-QQRCKNSIGSYKCSCRTGFHLHGNRHSCVD 220
D +C+D DEC +PC CKNS GS+ C C + L + C++
Sbjct: 796 FIYKPDLKTCEDIDECESSPCINGVCKNSPGSFICECSSESTLDPTKTICIE 847
Score = 77.4 bits (189), Expect = 6e-14
Identities = 61/236 (25%), Positives = 91/236 (38%), Gaps = 51/236 (21%)
Query: 75 CGSGICI-APNV--CSCQDGEQGATCPETHGPCGEYGCDLTCNHGGCQEVARV----CPV 127
CG+G C+ AP C C G + + E C G C + + C +
Sbjct: 1415 CGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECEI 1474
Query: 128 GFSMTETAVGIRCTDIDECV--TSSCEGHCVNTEGGFVCECGPGMQLSADRHSCQDT--- 182
G+ + + G CTD++EC+ T+ G+CVNT G ++C+C P +L+ R C DT
Sbjct: 1475 GYELDRS--GGNCTDVNECLDPTTCISGNCVNTPGSYICDCPPDFELNPTRVGCVDTRSG 1532
Query: 183 ----------------------------------DECLGTPCQQRCKNSIGSYKCSCRTG 208
+ GTPC+ + YK C G
Sbjct: 1533 NCYLDIRPRGDNGDTACSNEIGVGVSKASCCCSLGKAWGTPCEMCPAVNTSEYKILCPGG 1592
Query: 209 FHLHGNRHSCV--DVNECRRPLERRVCHHSCHNTVGSFLCTCRPGFRLRADRVSCE 262
N + + D++EC+ L C NT GSF C C G+ L D C+
Sbjct: 1593 EGFRPNPITVILEDIDECQE-LPGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCD 1647
Score = 76.3 bits (186), Expect = 1e-13
Identities = 72/263 (27%), Positives = 102/263 (38%), Gaps = 68/263 (25%)
Query: 48 GFGSGCCPGWAPSMGG------GHCTLP-LCSFGCGSGICIAPNV--CSCQDGEQ----G 94
G+ C G+ PS G C+LP +C FG + P + C C+ G + G
Sbjct: 1426 GYRCECDMGFVPSADGKACEDIDECSLPNICVFGTCHNL---PGLFRCECEIGYELDRSG 1482
Query: 95 ATCPETHGPCGEYGCDLTCNHGGCQEVARV----CPVGFSMTETAVGIRCTDIDECVTS- 149
C + + E TC G C CP F + T VG T C
Sbjct: 1483 GNCTDVN----ECLDPTTCISGNCVNTPGSYICDCPPDFELNPTRVGCVDTRSGNCYLDI 1538
Query: 150 -----SCEGHCVNTEG----------------GFVCECGPGMQLSADRHSC--------- 179
+ + C N G G CE P + S + C
Sbjct: 1539 RPRGDNGDTACSNEIGVGVSKASCCCSLGKAWGTPCEMCPAVNTSEYKILCPGGEGFRPN 1598
Query: 180 ------QDTDECLGTP--CQQ-RCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLER 230
+D DEC P CQ +C N+ GS++C C TG++L+ + C DVNEC P
Sbjct: 1599 PITVILEDIDECQELPGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNECETP--- 1655
Query: 231 RVC-HHSCHNTVGSFLCTCRPGF 252
+C +C+NTVG++ C C P +
Sbjct: 1656 GICGPGTCYNTVGNYTCICPPDY 1678
Score = 75.1 bits (183), Expect = 3e-13
Identities = 78/274 (28%), Positives = 103/274 (37%), Gaps = 65/274 (23%)
Query: 36 ERRRLGPHVCLSGFGS---GCCPGWAPSMGGGHCTLPLCSFG----CGSGICI---APNV 85
ER G C + GS C G+ S + C+ G C +G CI
Sbjct: 1896 ERDACGNGTCRNTIGSFNCRCNHGFILSHNNDCIDVDECASGNGNLCRNGQCINTVGSFQ 1955
Query: 86 CSCQDGEQ----GATCPETHGPCGEYGCDLTCNHGGCQEVAR----VCPVGFSMTETAVG 137
C C +G + G TC + + E C G CQ + +CP G+S+
Sbjct: 1956 CQCNEGYEVAPDGRTCVDINECLLE---PRKCAPGTCQNLDGSYRCICPPGYSLQNE--- 2009
Query: 138 IRCTDIDECVTSS---CEGHCVNTEGGFVCECGPGMQLSADRHSCQD------------- 181
+C DIDECV G C NTEG F C C G LS+ CQD
Sbjct: 2010 -KCEDIDECVEEPEICALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGG 2068
Query: 182 -----------TDECL--------GTPCQQRCKNSIGSYKCSCRTGFH-LHGNRHSCVDV 221
EC G PC+ +++ C G + G S VD+
Sbjct: 2069 KCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDDSAVDM 2128
Query: 222 NECRRPLERRVCHH-SCHNTVGSFLCTCRPGFRL 254
+EC+ P VC H C NT GS+ C C G+ L
Sbjct: 2129 DECKEP---DVCKHGQCINTDGSYRCECPFGYIL 2159
Score = 71.6 bits (174), Expect = 3e-12
Identities = 59/194 (30%), Positives = 80/194 (41%), Gaps = 30/194 (15%)
Query: 46 LSGFGSGCCPGWAPS----MGGGHCTLPLCSFGCGS-GICI---APNVCSCQDG----EQ 93
+ GF C PG+ + CT + CGS GIC C CQ G +
Sbjct: 2504 IGGFTCKCPPGFTQHHTSCIDNNECTSDINL--CGSKGICQNTPGSFTCECQRGFSLDQT 2561
Query: 94 GATCPETHGPCGEYGCDLTCNHGGCQEVAR----VCPVGFSMTETAVGIRCTDIDECVTS 149
G++C + G + C GCQ + CP G+ + +C D +EC+++
Sbjct: 2562 GSSCEDVDECEGNHRCQ-----HGCQNIIGGYRCSCPQGY--LQHYQWNQCVDENECLSA 2614
Query: 150 S-CEG-HCVNTEGGFVCECGPGMQLSADRHSCQDTDEC--LGTPCQQRCKNSIGSYKCSC 205
C G C NT G + C C G Q CQD +EC PC C N+ G Y C C
Sbjct: 2615 HICGGASCHNTLGSYKCMCPAGFQYEQFSGGCQDINECGSAQAPCSYGCSNTEGGYLCGC 2674
Query: 206 RTGFHLHGNRHSCV 219
G+ G H CV
Sbjct: 2675 PPGYFRIGQGH-CV 2687
Score = 68.9 bits (167), Expect = 2e-11
Identities = 65/228 (28%), Positives = 89/228 (39%), Gaps = 55/228 (24%)
Query: 88 CQDGEQGAT----CPETHGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDI 143
C+ GAT C + G C L CQ V +C G+S + G +C DI
Sbjct: 862 CEININGATLKSQCCSSLGAAWGSPCTL------CQ-VDPICGKGYSRIK---GTQCEDI 911
Query: 144 DECVT--SSCE-GHCVNTEGGFVCECGPGMQLSADRHSCQDT-----------DECL--- 186
DEC C+ G CVNT G F C+C GM L A C D +EC
Sbjct: 912 DECEVFPGVCKNGLCVNTRGSFKCQCPSGMTLDATGRICLDIRLETCFLRYEDEECTLPI 971
Query: 187 -GTPCQQRCKNSIGSY-------KCSCRT------------GF---HLHGNRHSCVDVNE 223
G C S+G+ +C R GF + + D+NE
Sbjct: 972 AGRHRMDACCCSVGAAWGTEECEECPMRNTPEYEELCPRGPGFATKEITNGKPFFKDINE 1031
Query: 224 CRRPLERRVCHHSCHNTVGSFLCTCRPGFRLRADRVSCEAFPKAVLAP 271
C+ + H C NT+GSF C C GF L ++ +C + ++P
Sbjct: 1032 CKM-IPSLCTHGKCRNTIGSFKCRCDSGFALDSEERNCTDIDECRISP 1078
Score = 68.6 bits (166), Expect = 3e-11
Identities = 67/243 (27%), Positives = 92/243 (37%), Gaps = 55/243 (22%)
Query: 51 SGCCPGWAPSMGGGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGATCPETHGPCGEYGCD 110
S CC + G CTL CG G C+D ++ C G C C
Sbjct: 873 SQCCSSLGAAWGSP-CTLCQVDPICGKGYSRIKGT-QCEDIDE---CEVFPGVCKNGLCV 927
Query: 111 LTCNHGGCQEVARVCPVGFSMTETAVGIRCTDI-----------DECV------------ 147
T CQ CP G MT A G C DI +EC
Sbjct: 928 NTRGSFKCQ-----CPSG--MTLDATGRICLDIRLETCFLRYEDEECTLPIAGRHRMDAC 980
Query: 148 ---------TSSCEGHCVNTEGGF--VCECGPGM---QLSADRHSCQDTDECLGTPC--- 190
T CE + + +C GPG +++ + +D +EC P
Sbjct: 981 CCSVGAAWGTEECEECPMRNTPEYEELCPRGPGFATKEITNGKPFFKDINECKMIPSLCT 1040
Query: 191 QQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVC-HHSCHNTVGSFLCTCR 249
+C+N+IGS+KC C +GF L +C D++ECR + +C C NT G F C C
Sbjct: 1041 HGKCRNTIGSFKCRCDSGFALDSEERNCTDIDECR--ISPDLCGRGQCVNTPGDFECKCD 1098
Query: 250 PGF 252
G+
Sbjct: 1099 EGY 1101
Score = 67.8 bits (164), Expect = 5e-11
Identities = 66/242 (27%), Positives = 92/242 (38%), Gaps = 45/242 (18%)
Query: 40 LGPHVCLSGFGSGCCPGWAPSMGGGHC-TLPLCSFGCGSGICIAPN---VCSCQDGEQGA 95
+G ++C+ G G P + C T P C +G C+ C C DG
Sbjct: 2269 IGTYMCICGPGYQRRPDGEGCVDENECQTKPGI---CENGRCLNTRGSYTCECNDG---F 2322
Query: 96 TCPETHGPCGEYGCDLTCNHGGC--QEVARVCPVGFSMTETAVGIRCTDIDECVTSSCEG 153
T C L G C + + +C +G S C C+G
Sbjct: 2323 TASPNQDEC------LDNREGYCFTEVLQNMCQIGSSNRNPVTKSECC---------CDG 2367
Query: 154 HCVNTEGGFVCECGPGMQLSADRHSCQ----------DTDEC--LGTPCQQ-RCKNSIGS 200
G CE P A + C D DEC + C+ C N GS
Sbjct: 2368 ---GRGWGPHCEICPFQGTVAFKKLCPHGRGFMTNGADIDECKVIHDVCRNGECVNDRGS 2424
Query: 201 YKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTCRPGFRLRADRVS 260
Y C C+TG+ SCVD+NEC + + C+ C NT GS+ C+C G+ L+ D S
Sbjct: 2425 YHCICKTGYTPDITGTSCVDLNECNQ--APKPCNFICKNTEGSYQCSCPKGYILQEDGRS 2482
Query: 261 CE 262
C+
Sbjct: 2483 CK 2484
Score = 63.9 bits (154), Expect = 7e-10
Identities = 65/226 (28%), Positives = 86/226 (38%), Gaps = 48/226 (21%)
Query: 75 CGSGICI---APNVCSCQDGEQ----GATCPETHGPCGEYGCDLTCNHGGCQEVAR---- 123
C +GIC C C G + G C + + L C++G C+
Sbjct: 734 CPNGICENLRGTYKCICNSGYEVDSTGKNCVDINECVLN---SLLCDNGQCRNTPGSFVC 790
Query: 124 VCPVGFSMTETAVGIRCTDIDECVTSSC-EGHCVNTEGGFVCECGPGMQLSADRHSCQDT 182
CP GF C DIDEC +S C G C N+ G F+CEC L + C +T
Sbjct: 791 TCPKGFIYKPDLK--TCEDIDECESSPCINGVCKNSPGSFICECSSESTLDPTKTICIET 848
Query: 183 --DECLGTPCQQRCKNSIG-----SYKCS------------------CRTGF-HLHGNRH 216
C T RC+ +I S CS C G+ + G +
Sbjct: 849 IKGTCWQTVIDGRCEININGATLKSQCCSSLGAAWGSPCTLCQVDPICGKGYSRIKGTQ- 907
Query: 217 SCVDVNECRRPLERRVCHHS-CHNTVGSFLCTCRPGFRLRADRVSC 261
C D++EC + VC + C NT GSF C C G L A C
Sbjct: 908 -CEDIDECE--VFPGVCKNGLCVNTRGSFKCQCPSGMTLDATGRIC 950
Score = 61.6 bits (148), Expect = 3e-09
Identities = 62/242 (25%), Positives = 86/242 (35%), Gaps = 45/242 (18%)
Query: 70 LCSFGCGSGICIAPNVCSCQDG----EQGATCPETHGPCGEYGCDLTCNHGGCQEV--AR 123
LC+F C + C C G E C + C E D T C+ +
Sbjct: 2216 LCAFRCVN--TYGSYECKCPVGYVLREDRRMCKD-EDECEEGKHDCTEKQMECKNLIGTY 2272
Query: 124 VCPVGFSMTETAVGIRCTDIDECVTSS--CE-GHCVNTEGGFVCECGPGMQLSADRHSCQ 180
+C G G C D +EC T CE G C+NT G + CEC G S ++ C
Sbjct: 2273 MCICGPGYQRRPDGEGCVDENECQTKPGICENGRCLNTRGSYTCECNDGFTASPNQDECL 2332
Query: 181 DTDE--CLGTPCQQRC------KNSIGSYKCSCRTGF----------------------H 210
D E C Q C +N + +C C G H
Sbjct: 2333 DNREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEICPFQGTVAFKKLCPH 2392
Query: 211 LHGNRHSCVDVNECRRPLERRVCHHS-CHNTVGSFLCTCRPGFRLRADRVSCEAFPKAVL 269
G + D++EC+ + VC + C N GS+ C C+ G+ SC +
Sbjct: 2393 GRGFMTNGADIDECK--VIHDVCRNGECVNDRGSYHCICKTGYTPDITGTSCVDLNECNQ 2450
Query: 270 AP 271
AP
Sbjct: 2451 AP 2452
Score = 53.9 bits (128), Expect = 7e-07
Identities = 56/208 (26%), Positives = 71/208 (34%), Gaps = 52/208 (25%)
Query: 97 CPETHGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTE-TAVGIRCTDIDECVTSSC--EG 153
C E G C C T C+ CP G+ + E T V C D++EC T G
Sbjct: 1610 CQELPGLCQGGKCINTFGSFQCR-----CPTGYYLNEDTRV---CDDVNECETPGICGPG 1661
Query: 154 HCVNTEGGFVCECGPGMQLSADRHSCQDTDECL--------------------------- 186
C NT G + C C P ++C D L
Sbjct: 1662 TCYNTVGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGELLFNMTKKMCCC 1721
Query: 187 --------GTPCQQRCKNSIGSYKCSC---RTGFHLHGNRHSCVDVNECRRPLERRVCHH 235
PC+Q S + C R GF + VD++ECR VC +
Sbjct: 1722 SYNIGRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGLPVDIDECREI--PGVCEN 1779
Query: 236 S-CHNTVGSFLCTCRPGFRLRADRVSCE 262
C N VGSF C C GF + CE
Sbjct: 1780 GVCINMVGSFRCECPVGFFYNDKLLVCE 1807
Score = 42.4 bits (98), Expect = 0.002
Identities = 75/299 (25%), Positives = 102/299 (34%), Gaps = 80/299 (26%)
Query: 480 CPSGPCQTPPQTDCCTCVPVRCYFHGRWYADGAVFSGGGDECTTCVCQNGEVECSFMPCP 539
C +G C+ P + CTC G Y DEC + C NG C P
Sbjct: 776 CDNGQCRNTPGSFVCTCP------KGFIYKPDLKTCEDIDECESSPCING--VCKNSPGS 827
Query: 540 ELACPREEWRLGPGQ-CCF-----TCQEPTPSTGCSLDDNGVEF------PIGQIWSPGD 587
+ E L P + C TC + C ++ NG +G W G
Sbjct: 828 FICECSSESTLDPTKTICIETIKGTCWQTVIDGRCEININGATLKSQCCSSLGAAW--GS 885
Query: 588 PCELC----ICQADGSVSCKRTDC--VDSCPHPIRIPGQC----CPD--------CSAGC 629
PC LC IC G K T C +D C PG C C + C +G
Sbjct: 886 PCTLCQVDPIC-GKGYSRIKGTQCEDIDECE---VFPGVCKNGLCVNTRGSFKCQCPSGM 941
Query: 630 TY--TGRIF-----------YNNE--TFPSV----LDPCLSCI-CLLGSVACSPVDCPIT 669
T TGRI Y +E T P +D C + G+ C +CP+
Sbjct: 942 TLDATGRICLDIRLETCFLRYEDEECTLPIAGRHRMDACCCSVGAAWGTEECE--ECPMR 999
Query: 670 CTYPFHPDGECCPVCRDCNYEGRKVANGQVFTLDDEPCT---------RCTCQLGEVSC 719
T + E CP R + +++ NG+ F D C +C +G C
Sbjct: 1000 NTPEYE---ELCP--RGPGFATKEITNGKPFFKDINECKMIPSLCTHGKCRNTIGSFKC 1053
Score = 38.1 bits (87), Expect = 0.040
Identities = 74/300 (24%), Positives = 99/300 (33%), Gaps = 63/300 (21%)
Query: 480 CPSGPCQTPPQTDCCTCVPVRCYFHGRWYADGAVFSGGGDECTTCVCQNGEVECSFMPCP 539
C +G C + C C PV G +Y D + DEC QNG V C
Sbjct: 1777 CENGVCINMVGSFRCEC-PV-----GFFYNDKLLVCEDIDEC-----QNGPVCQRNAECI 1825
Query: 540 ELACPREEWRLGPGQCCFTCQEPTPSTGCSLDDNGVEFPIGQIWSPGDPCEL-----CIC 594
A G +C STG D N + I I S G + C+C
Sbjct: 1826 NTA--------GSYRCDCKPGYRFTSTGQCNDRNECQ-EIPNICSHGQCIDTVGSFYCLC 1876
Query: 595 QADGSVSCKRTDCVD--SCPHPIRIPGQC---CPDCSAGCTYTGRIFYNNETFPSVLDPC 649
+ +T C+D C G C + C + + +NN+ +D C
Sbjct: 1877 HTGFKTNDDQTMCLDINECERDACGNGTCRNTIGSFNCRCNHGFILSHNNDCID--VDEC 1934
Query: 650 LS----------CICLLGSVACSPVDCPITCTYPFHPDGECCPVCRDCNYEGRKVANGQV 699
S CI +GS C + Y PDG C +C E RK A G
Sbjct: 1935 ASGNGNLCRNGQCINTVGSFQCQCNE-----GYEVAPDGRTCVDINECLLEPRKCAPGTC 1989
Query: 700 FTLDDEPCTRCTC----QLGEVSCEKVPCQRACADPALLPGDCCSS--------CPDSLS 747
LD RC C L CE + +P + CS+ CP+ S
Sbjct: 1990 QNLDGS--YRCICPPGYSLQNEKCEDI--DECVEEPEICALGTCSNTEGSFKCLCPEGFS 2045
>gi|37693519 BMP-binding endothelial regulator precursor protein
[Homo sapiens]
Length = 685
Score = 125 bits (315), Expect = 1e-28
Identities = 96/319 (30%), Positives = 129/319 (40%), Gaps = 54/319 (16%)
Query: 400 TEPGCSQCWCEDGKVTCEKVRCEAA---CSHPIPSRDGGCCPSCTGCFHSGVVRAEGDVF 456
T+ C C C + +VTC++ +C C+ I R G CC C GC + G +
Sbjct: 63 TDNPCIMCVCLNKEVTCKREKCPVLSRDCALAIKQR-GACCEQCKGCTYEGNTYNSSFKW 121
Query: 457 SPPNENCTVCVCLAGNVSCISPECPSGPCQTPPQT--DCCTCVPVRCYFHGRWYADGAVF 514
P E C + C G V+ C C+ P + CC P C F G Y +G F
Sbjct: 122 QSPAEPCVLRQCQEGVVTESGVRCVVH-CKNPLEHLGMCCPTCP-GCVFEGVQYQEGEEF 179
Query: 515 SGGGDECTTCVCQNGEVECSFMPCPELACPREEWRLGPGQCCFTCQE-----PTPSTGC- 568
G +CT C C G +C CP L+CP+ + PGQCC C P C
Sbjct: 180 QPEGSKCTKCSCTGGRTQCVREVCPILSCPQHLSHIPPGQCCPKCLGQRKVFDLPFGSCL 239
Query: 569 ---SLDDNGVEFPIGQIWSPGDPCELCICQADGSVSCKRTDCVDSCPHPIRI-PGQ--CC 622
+ DNG F D C C C+ D +V CKR C HP GQ CC
Sbjct: 240 FRSDVYDNGSSFLY-------DNCTACTCR-DSTVVCKR-----KCSHPGGCDQGQEGCC 286
Query: 623 PDCSAG--------CTYTGRIFYNNETFPSVLDPCLSCICLLGSVACSPVDC-PITCTYP 673
+C C + +IF + E + S+ C C C+ G C C PI+
Sbjct: 287 EECLLRVPPEDIKVCKFGNKIFQDGEMWSSI--NCTICACVKGRTECRNKQCIPISSC-- 342
Query: 674 FHPDGE------CCPVCRD 686
P G+ CCP+C +
Sbjct: 343 --PQGKILNRKGCCPICTE 359
Score = 108 bits (270), Expect = 2e-23
Identities = 85/282 (30%), Positives = 110/282 (39%), Gaps = 45/282 (15%)
Query: 521 CTTCVCQNGEVECSFMPCPELACPREEWRLGPGQCCFTCQEPTPSTGCSLDDNGVEFPIG 580
C CVC N EV C CP L+ G CC C+ GC+ + N
Sbjct: 67 CIMCVCLNKEVTCKREKCPVLSRDCALAIKQRGACCEQCK------GCTYEGNTYNSSFK 120
Query: 581 QIW-SPGDPCELCICQADGSVSCKRTDCVDSCPHPIRIPGQCCPDCSAGCTYTGRIFYNN 639
W SP +PC L CQ +G V+ CV C +P+ G CCP C GC + G +
Sbjct: 121 --WQSPAEPCVLRQCQ-EGVVTESGVRCVVHCKNPLEHLGMCCPTCP-GCVFEGVQYQEG 176
Query: 640 ETFPSVLDPCLSCICLLGSVACSPVDCPITCTYPFH----PDGECCPVCR---------- 685
E F C C C G C CPI + P H P G+CCP C
Sbjct: 177 EEFQPEGSKCTKCSCTGGRTQCVREVCPIL-SCPQHLSHIPPGQCCPKCLGQRKVFDLPF 235
Query: 686 -DCNYEGRKVANGQVFTLDDEPCTRCTCQLGEVSCEKVPCQRACADPALL---PGDCCSS 741
C + NG F D+ CT CTC+ V C+R C+ P CC
Sbjct: 236 GSCLFRSDVYDNGSSFLYDN--CTACTCR-----DSTVVCKRKCSHPGGCDQGQEGCCEE 288
Query: 742 CPDSLSPLEEKQGLSPHGNVAFSKAGRSLHGDTEAPVNCSSC 783
C + P + K + GN F G+ + +NC+ C
Sbjct: 289 CLLRVPPEDIK--VCKFGNKIFQ------DGEMWSSINCTIC 322
Score = 102 bits (255), Expect = 1e-21
Identities = 54/162 (33%), Positives = 74/162 (45%), Gaps = 8/162 (4%)
Query: 587 DPCELCICQADGSVSCKRTDCV---DSCPHPIRIPGQCCPDCSAGCTYTGRIFYNNETFP 643
+PC +C+C + V+CKR C C I+ G CC C GCTY G + ++ +
Sbjct: 65 NPCIMCVC-LNKEVTCKREKCPVLSRDCALAIKQRGACCEQCK-GCTYEGNTYNSSFKWQ 122
Query: 644 SVLDPCLSCICLLGSVACSPVDCPITCTYPFHPDGECCPVCRDCNYEGRKVANGQVFTLD 703
S +PC+ C G V S V C + C P G CCP C C +EG + G+ F +
Sbjct: 123 SPAEPCVLRQCQEGVVTESGVRCVVHCKNPLEHLGMCCPTCPGCVFEGVQYQEGEEFQPE 182
Query: 704 DEPCTRCTCQLGEVSCEKVPCQRACADPALL---PGDCCSSC 742
CT+C+C G C + C L PG CC C
Sbjct: 183 GSKCTKCSCTGGRTQCVREVCPILSCPQHLSHIPPGQCCPKC 224
Score = 94.4 bits (233), Expect = 5e-19
Identities = 87/328 (26%), Positives = 127/328 (38%), Gaps = 56/328 (17%)
Query: 452 EGDVFSPP---NENCTVCVCLAGNVSCISPECP--SGPCQTPPQTDCCTCVPVR-CYFHG 505
EG+V P + C +CVCL V+C +CP S C + C + C + G
Sbjct: 53 EGEVLQIPFITDNPCIMCVCLNKEVTCKREKCPVLSRDCALAIKQRGACCEQCKGCTYEG 112
Query: 506 RWYADGAVFSGGGDECTTCVCQNGEVECSFMPCPELACPREEWRLGPGQCCFTCQEPTPS 565
Y + + C CQ G V S + C + C LG CC TC
Sbjct: 113 NTYNSSFKWQSPAEPCVLRQCQEGVVTESGVRCV-VHCKNPLEHLG--MCCPTCP----- 164
Query: 566 TGCSLDDNGVEFPIGQIWSP-GDPCELCICQADGSVSCKRTDC-VDSCPHPIRI--PGQC 621
GC + GV++ G+ + P G C C C G C R C + SCP + PGQC
Sbjct: 165 -GCVFE--GVQYQEGEEFQPEGSKCTKCSCTG-GRTQCVREVCPILSCPQHLSHIPPGQC 220
Query: 622 CPDCSA----------GCTYTGRIFYNNETFPSVLDPCLSCICLLGSVACSPVDCPITCT 671
CP C C + ++ N +F + D C +C C +V C C+
Sbjct: 221 CPKCLGQRKVFDLPFGSCLFRSDVYDNGSSF--LYDNCTACTCRDSTVVCKR-----KCS 273
Query: 672 YPFHPD-GE--CCPVC---------RDCNYEGRKVANGQVFTLDDEPCTRCTCQLGEVSC 719
+P D G+ CC C + C + + +G++++ + CT C C G C
Sbjct: 274 HPGGCDQGQEGCCEECLLRVPPEDIKVCKFGNKIFQDGEMWSSIN--CTICACVKGRTEC 331
Query: 720 EKVPCQRACADP---ALLPGDCCSSCPD 744
C + P L CC C +
Sbjct: 332 RNKQCIPISSCPQGKILNRKGCCPICTE 359
Score = 72.4 bits (176), Expect = 2e-12
Identities = 42/154 (27%), Positives = 60/154 (38%), Gaps = 8/154 (5%)
Query: 594 CQADGSVSCKRTDCVDSCPHPIRIPGQCCPDCSAGCTYTGRIFYNNETFPSVLD-PCLSC 652
C+ ++C ++ P+ + A C G + P + D PC+ C
Sbjct: 15 CRRSPGITCCVLLLLNCSGVPMSLASSFLTGSVAKCENEGEVLQ----IPFITDNPCIMC 70
Query: 653 ICLLGSVACSPVDCPIT---CTYPFHPDGECCPVCRDCNYEGRKVANGQVFTLDDEPCTR 709
+CL V C CP+ C G CC C+ C YEG + + EPC
Sbjct: 71 VCLNKEVTCKREKCPVLSRDCALAIKQRGACCEQCKGCTYEGNTYNSSFKWQSPAEPCVL 130
Query: 710 CTCQLGEVSCEKVPCQRACADPALLPGDCCSSCP 743
CQ G V+ V C C +P G CC +CP
Sbjct: 131 RQCQEGVVTESGVRCVVHCKNPLEHLGMCCPTCP 164
Score = 52.8 bits (125), Expect = 2e-06
Identities = 32/126 (25%), Positives = 52/126 (41%), Gaps = 19/126 (15%)
Query: 386 CWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVRCEAACSHPIPSRDG--GCCPSC--- 440
C ++++ S + C+ C C D V C++ CSHP G GCC C
Sbjct: 238 CLFRSDVYDNGSSFLYDNCTACTCRDSTVVCKR-----KCSHPGGCDQGQEGCCEECLLR 292
Query: 441 ------TGCFHSGVVRAEGDVFSPPNENCTVCVCLAGNVSCISPEC-PSGPCQTPPQTDC 493
C + +G+++S + NCT+C C+ G C + +C P C +
Sbjct: 293 VPPEDIKVCKFGNKIFQDGEMWS--SINCTICACVKGRTECRNKQCIPISSCPQGKILNR 350
Query: 494 CTCVPV 499
C P+
Sbjct: 351 KGCCPI 356
Score = 34.3 bits (77), Expect = 0.57
Identities = 17/46 (36%), Positives = 22/46 (47%), Gaps = 4/46 (8%)
Query: 399 WTEPGCSQCWCEDGKVTCEKVRCEAACSHP---IPSRDGGCCPSCT 441
W+ C+ C C G+ C +C S P I +R GCCP CT
Sbjct: 314 WSSINCTICACVKGRTECRNKQCIPISSCPQGKILNRK-GCCPICT 358
>gi|190343004 EGF-containing fibulin-like extracellular matrix
protein 2 [Homo sapiens]
Length = 443
Score = 123 bits (309), Expect = 7e-28
Identities = 57/136 (41%), Positives = 76/136 (55%), Gaps = 7/136 (5%)
Query: 125 CPVGFSMTETAVGIRCTDIDECVTSSCEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDE 184
CP G+ +G C DIDEC C+ CVN G F C+C PG QL + SC D +E
Sbjct: 151 CPDGYRK----IGPECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNE 206
Query: 185 C-LGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGS 243
C +G PC+QRC NS G++ C C G+ LH + SC D++EC +C + C N G
Sbjct: 207 CDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDEC--SYSSYLCQYRCVNEPGR 264
Query: 244 FLCTCRPGFRLRADRV 259
F C C G++L A R+
Sbjct: 265 FSCHCPQGYQLLATRL 280
Score = 100 bits (250), Expect = 5e-21
Identities = 54/141 (38%), Positives = 65/141 (46%), Gaps = 12/141 (8%)
Query: 125 CPVGFSMTETAVGIRCTDIDECVTS--SCEGH--CVNTEGGFVCECGPGMQLSADRHSCQ 180
CP G+ + C D+DEC + C C N G + C C G + C
Sbjct: 109 CPPGYEPDDQD---SCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPE--CV 163
Query: 181 DTDECLGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNT 240
D DEC CQ RC N GS++C C GF L N SCVDVNEC C C N+
Sbjct: 164 DIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAP---CEQRCFNS 220
Query: 241 VGSFLCTCRPGFRLRADRVSC 261
G+FLC C G+ L D SC
Sbjct: 221 YGTFLCRCHQGYELHRDGFSC 241
Score = 59.3 bits (142), Expect = 2e-08
Identities = 38/119 (31%), Positives = 50/119 (42%), Gaps = 30/119 (25%)
Query: 165 ECGPGMQLSADRHSCQDTDECLGTP--C--QQRCKNSIGSYKCSCRTGF---HLHG---- 213
EC G + D C+D +ECL P C + +C N G Y C R+ LHG
Sbjct: 38 ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPP 97
Query: 214 -------------------NRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTCRPGFR 253
++ SCVDV+EC + L CHN GS+ CTC G+R
Sbjct: 98 PPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYR 156
>gi|86788132 EGF-containing fibulin-like extracellular matrix
protein 1 precursor [Homo sapiens]
Length = 493
Score = 122 bits (307), Expect = 1e-27
Identities = 60/143 (41%), Positives = 80/143 (55%), Gaps = 13/143 (9%)
Query: 125 CPVGFSMTETAVGIRCTDIDECV--TSSCEGH--CVNTEGGFVCECGPGMQLSADRHSCQ 180
C G+ +E V C DIDEC T +C C+N G F C+C PG Q ++ C
Sbjct: 159 CAAGYEQSEHNV---CQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQ--CV 213
Query: 181 DTDECLGTP-CQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHN 239
D DEC P C QRC N+ GS+ C C GF L N ++CVD+NEC + C C+N
Sbjct: 214 DIDECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQ---CAQQCYN 270
Query: 240 TVGSFLCTCRPGFRLRADRVSCE 262
+GSF+C C G+ L +DR++CE
Sbjct: 271 ILGSFICQCNQGYELSSDRLNCE 293
Score = 115 bits (287), Expect = 3e-25
Identities = 53/136 (38%), Positives = 75/136 (55%), Gaps = 8/136 (5%)
Query: 125 CPVGFSMTETAVGIRCTDIDEC-VTSSCEGHCVNTEGGFVCECGPGMQLSADRHSCQDTD 183
CP G+ G +C DIDEC + C CVNT G F C+C PG QL+A+ ++C D +
Sbjct: 201 CPPGYQKR----GEQCVDIDECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDIN 256
Query: 184 EC-LGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVG 242
EC C Q+C N +GS+ C C G+ L +R +C D++ECR +C + C N G
Sbjct: 257 ECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRT--SSYLCQYQCVNEPG 314
Query: 243 SFLCTCRPGFRLRADR 258
F C C G+++ R
Sbjct: 315 KFSCMCPQGYQVVRSR 330
Score = 93.6 bits (231), Expect = 8e-19
Identities = 62/184 (33%), Positives = 82/184 (44%), Gaps = 17/184 (9%)
Query: 76 GSGICIAPNVCSCQDGEQGATCPETHGPCGEYGCDLT-CN-----HGGCQEVARV----C 125
G+ C A VC G CP + GE D+ C H C C
Sbjct: 180 GTHNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQC 239
Query: 126 PVGFSMTETAVGIRCTDIDECVTSS-CEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDE 184
GF + A C DI+EC S+ C C N G F+C+C G +LS+DR +C+D DE
Sbjct: 240 SPGFQLA--ANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDE 297
Query: 185 CLGTP--CQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVG 242
C + CQ +C N G + C C G+ + +R +C D+NEC E R C N G
Sbjct: 298 CRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSR-TCQDINECETTNECRE-DEMCWNYHG 355
Query: 243 SFLC 246
F C
Sbjct: 356 GFRC 359
Score = 30.4 bits (67), Expect = 8.2
Identities = 16/47 (34%), Positives = 22/47 (46%), Gaps = 4/47 (8%)
Query: 165 ECGPGMQLSADRHSCQDTDECLGTP--CQ--QRCKNSIGSYKCSCRT 207
+C G + R C+D DEC P C+ +C N G Y C +T
Sbjct: 28 QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKT 74
>gi|86788015 EGF-containing fibulin-like extracellular matrix
protein 1 precursor [Homo sapiens]
Length = 493
Score = 122 bits (307), Expect = 1e-27
Identities = 60/143 (41%), Positives = 80/143 (55%), Gaps = 13/143 (9%)
Query: 125 CPVGFSMTETAVGIRCTDIDECV--TSSCEGH--CVNTEGGFVCECGPGMQLSADRHSCQ 180
C G+ +E V C DIDEC T +C C+N G F C+C PG Q ++ C
Sbjct: 159 CAAGYEQSEHNV---CQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQ--CV 213
Query: 181 DTDECLGTP-CQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHN 239
D DEC P C QRC N+ GS+ C C GF L N ++CVD+NEC + C C+N
Sbjct: 214 DIDECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQ---CAQQCYN 270
Query: 240 TVGSFLCTCRPGFRLRADRVSCE 262
+GSF+C C G+ L +DR++CE
Sbjct: 271 ILGSFICQCNQGYELSSDRLNCE 293
Score = 115 bits (287), Expect = 3e-25
Identities = 53/136 (38%), Positives = 75/136 (55%), Gaps = 8/136 (5%)
Query: 125 CPVGFSMTETAVGIRCTDIDEC-VTSSCEGHCVNTEGGFVCECGPGMQLSADRHSCQDTD 183
CP G+ G +C DIDEC + C CVNT G F C+C PG QL+A+ ++C D +
Sbjct: 201 CPPGYQKR----GEQCVDIDECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDIN 256
Query: 184 EC-LGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVG 242
EC C Q+C N +GS+ C C G+ L +R +C D++ECR +C + C N G
Sbjct: 257 ECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRT--SSYLCQYQCVNEPG 314
Query: 243 SFLCTCRPGFRLRADR 258
F C C G+++ R
Sbjct: 315 KFSCMCPQGYQVVRSR 330
Score = 93.6 bits (231), Expect = 8e-19
Identities = 62/184 (33%), Positives = 82/184 (44%), Gaps = 17/184 (9%)
Query: 76 GSGICIAPNVCSCQDGEQGATCPETHGPCGEYGCDLT-CN-----HGGCQEVARV----C 125
G+ C A VC G CP + GE D+ C H C C
Sbjct: 180 GTHNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQC 239
Query: 126 PVGFSMTETAVGIRCTDIDECVTSS-CEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDE 184
GF + A C DI+EC S+ C C N G F+C+C G +LS+DR +C+D DE
Sbjct: 240 SPGFQLA--ANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDE 297
Query: 185 CLGTP--CQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVG 242
C + CQ +C N G + C C G+ + +R +C D+NEC E R C N G
Sbjct: 298 CRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSR-TCQDINECETTNECRE-DEMCWNYHG 355
Query: 243 SFLC 246
F C
Sbjct: 356 GFRC 359
Score = 30.4 bits (67), Expect = 8.2
Identities = 16/47 (34%), Positives = 22/47 (46%), Gaps = 4/47 (8%)
Query: 165 ECGPGMQLSADRHSCQDTDECLGTP--CQ--QRCKNSIGSYKCSCRT 207
+C G + R C+D DEC P C+ +C N G Y C +T
Sbjct: 28 QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKT 74
>gi|9665262 EGF-containing fibulin-like extracellular matrix protein
1 precursor [Homo sapiens]
Length = 493
Score = 122 bits (307), Expect = 1e-27
Identities = 60/143 (41%), Positives = 80/143 (55%), Gaps = 13/143 (9%)
Query: 125 CPVGFSMTETAVGIRCTDIDECV--TSSCEGH--CVNTEGGFVCECGPGMQLSADRHSCQ 180
C G+ +E V C DIDEC T +C C+N G F C+C PG Q ++ C
Sbjct: 159 CAAGYEQSEHNV---CQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQ--CV 213
Query: 181 DTDECLGTP-CQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHN 239
D DEC P C QRC N+ GS+ C C GF L N ++CVD+NEC + C C+N
Sbjct: 214 DIDECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQ---CAQQCYN 270
Query: 240 TVGSFLCTCRPGFRLRADRVSCE 262
+GSF+C C G+ L +DR++CE
Sbjct: 271 ILGSFICQCNQGYELSSDRLNCE 293
Score = 115 bits (287), Expect = 3e-25
Identities = 53/136 (38%), Positives = 75/136 (55%), Gaps = 8/136 (5%)
Query: 125 CPVGFSMTETAVGIRCTDIDEC-VTSSCEGHCVNTEGGFVCECGPGMQLSADRHSCQDTD 183
CP G+ G +C DIDEC + C CVNT G F C+C PG QL+A+ ++C D +
Sbjct: 201 CPPGYQKR----GEQCVDIDECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDIN 256
Query: 184 EC-LGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVG 242
EC C Q+C N +GS+ C C G+ L +R +C D++ECR +C + C N G
Sbjct: 257 ECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRT--SSYLCQYQCVNEPG 314
Query: 243 SFLCTCRPGFRLRADR 258
F C C G+++ R
Sbjct: 315 KFSCMCPQGYQVVRSR 330
Score = 93.6 bits (231), Expect = 8e-19
Identities = 62/184 (33%), Positives = 82/184 (44%), Gaps = 17/184 (9%)
Query: 76 GSGICIAPNVCSCQDGEQGATCPETHGPCGEYGCDLT-CN-----HGGCQEVARV----C 125
G+ C A VC G CP + GE D+ C H C C
Sbjct: 180 GTHNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQC 239
Query: 126 PVGFSMTETAVGIRCTDIDECVTSS-CEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDE 184
GF + A C DI+EC S+ C C N G F+C+C G +LS+DR +C+D DE
Sbjct: 240 SPGFQLA--ANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDE 297
Query: 185 CLGTP--CQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVG 242
C + CQ +C N G + C C G+ + +R +C D+NEC E R C N G
Sbjct: 298 CRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSR-TCQDINECETTNECRE-DEMCWNYHG 355
Query: 243 SFLC 246
F C
Sbjct: 356 GFRC 359
Score = 30.4 bits (67), Expect = 8.2
Identities = 16/47 (34%), Positives = 22/47 (46%), Gaps = 4/47 (8%)
Query: 165 ECGPGMQLSADRHSCQDTDECLGTP--CQ--QRCKNSIGSYKCSCRT 207
+C G + R C+D DEC P C+ +C N G Y C +T
Sbjct: 28 QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKT 74
>gi|66346695 fibrillin 2 precursor [Homo sapiens]
Length = 2912
Score = 121 bits (303), Expect = 4e-27
Identities = 85/276 (30%), Positives = 110/276 (39%), Gaps = 57/276 (20%)
Query: 41 GPHVCLSGFGSGCCPGWAPSMGGGHCTLPLCSFGCGSGICIAPNVCSCQDGE-------- 92
GP+VC S F S CCPGW GG C +P+C CG G C PN+C+C G+
Sbjct: 85 GPNVCGSRFHSYCCPGWKTLPGGNQCIVPICRNSCGDGFCSRPNMCTCSSGQISSTCGSK 144
Query: 93 ----------QGATCPETHGPC---------GEYGCDLTCNHGG-CQEVAR-VCPVGFSM 131
G TC + H C G+ C+ C +GG C R C GF+
Sbjct: 145 SIQQCSVRCMNGGTCADDHCQCQKGYIGTYCGQPVCENGCQNGGRCIGPNRCACVYGFTG 204
Query: 132 TETAVGIRCTDIDECVTSS-CEGH----------CVNTEG---GFVCECGPGMQLSADRH 177
+ R V + C+G C T G G CE P R
Sbjct: 205 PQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQPQPCRRG 264
Query: 178 --------SCQDTDECLGTP--CQQ-RCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRR 226
+CQD DEC P CQ C N++GS++C C G C D++EC
Sbjct: 265 FIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECS- 323
Query: 227 PLERRVCHHS-CHNTVGSFLCTCRPGFRLRADRVSC 261
+ +C C NTVGS+ C C G+ D C
Sbjct: 324 -IIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRC 358
Score = 114 bits (284), Expect = 6e-25
Identities = 84/277 (30%), Positives = 110/277 (39%), Gaps = 65/277 (23%)
Query: 46 LSGFGSGCCPGWAPSMGGGHCT-LPLCSFG---CGSGICI---APNVCSCQDGEQ----- 93
+ F C G+A M +CT + C CGSGIC+ C C +G +
Sbjct: 1093 IGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGYESGFMM 1152
Query: 94 ------------------GATCPETHG------PCGEY------------GCDLT---CN 114
G TC T G P G C L+ C
Sbjct: 1153 MKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCR 1212
Query: 115 HGGCQEVARV----CPVGFSMTETAVGIRCTDIDECV--TSSCEGHCVNTEGGFVCECGP 168
+G C + C G+ T G CTDIDEC+ C+ C N+EG + C C
Sbjct: 1213 NGKCVNMIGTYQCSCNPGYQATPDRQG--CTDIDECMIMNGGCDTQCTNSEGSYECSCSE 1270
Query: 169 GMQLSADRHSCQDTDECLGTP--CQQ-RCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECR 225
G L D SC D DEC P C +C N G Y+C C GF + +C+DVNEC
Sbjct: 1271 GYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNEC- 1329
Query: 226 RPLERRVCHHS-CHNTVGSFLCTCRPGFRLRADRVSC 261
L +C C NT GSF+C C+ G+ ++ C
Sbjct: 1330 -DLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGC 1365
Score = 114 bits (284), Expect = 6e-25
Identities = 82/240 (34%), Positives = 106/240 (44%), Gaps = 41/240 (17%)
Query: 42 PHVCLSG--------FGSGCCPGWAPSMGGGHCT-LPLCSFGCGSGICIAPNV-----CS 87
P++C +G F C G+ + G C L CS I N CS
Sbjct: 2457 PNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCS 2516
Query: 88 CQDG----EQGATCPETHG-PCGEYGCDLTCNH--GG--CQEVARVCPVGFSMTETAVGI 138
C G E G TC + ++ C C + GG C+ CP GF+ TA
Sbjct: 2517 CPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCK-----CPPGFTQHHTA--- 2568
Query: 139 RCTDIDECVTS----SCEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDECLGTP-CQQR 193
C D +EC + +G C NT G F CEC G L A +C+D DEC G CQ
Sbjct: 2569 -CIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHG 2627
Query: 194 CKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVC-HHSCHNTVGSFLCTCRPGF 252
C+N +G Y+C C G+ H + CVD NEC P C SC+NT+GS+ C C GF
Sbjct: 2628 CQNILGGYRCGCPQGYIQHYQWNQCVDENECSNP---NACGSASCYNTLGSYKCACPSGF 2684
Score = 113 bits (283), Expect = 7e-25
Identities = 79/238 (33%), Positives = 106/238 (44%), Gaps = 25/238 (10%)
Query: 42 PHVCL--------SGFGSGCCPGWAPSMGGGHC---TLPLCSFGCGSGICIAPNVCSCQD 90
P++CL GF C PG+ S G C C +G C P +
Sbjct: 2064 PNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTK 2123
Query: 91 GEQGATCPETHGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECVTSS 150
+ C + G C+L C +CP G + R D++EC+ S
Sbjct: 2124 AK--CCCSKMPGEGWGDPCEL-CPKDDEVAFQDLCPYGHGTVPSLHDTR-EDVNECLESP 2179
Query: 151 ---CEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDEC-LGTPCQQ-RCKNSIGSYKCSC 205
G C+NT+G F CEC G L C DTDEC +G PC C N IGS++C+C
Sbjct: 2180 GICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFECNC 2239
Query: 206 RTGFHLHGNRHSCVDVNEC-RRPLERRVCHHSCHNTVGSFLCTCRPGFRLRADRVSCE 262
GF G +C D+NEC + PL +C C NT GS+ CTC G+ LR D+ C+
Sbjct: 2240 NEGFE-PGPMMNCEDINECAQNPL---LCAFRCMNTFGSYECTCPIGYALREDQKMCK 2293
Score = 110 bits (274), Expect = 8e-24
Identities = 84/243 (34%), Positives = 108/243 (44%), Gaps = 37/243 (15%)
Query: 42 PHVCLSGFGSGCCPGWAPSMGGG---HCTLPLCSFG---CGSGICIAPNV----CSCQDG 91
P V +G G+G G P + G + T+ +C C +G CI P V C C G
Sbjct: 469 PGVGGAGVGAG---GQGPIITGLTILNQTIDICKHHANLCLNGRCI-PTVSSYRCECNMG 524
Query: 92 ---EQGATCPE----THGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDID 144
+ C + T PC C T C+ C GF T T C DID
Sbjct: 525 YKQDANGDCIDVDECTSNPCTNGDCVNTPGSYYCK-----CHAGFQRTPTKQA--CIDID 577
Query: 145 ECVTSSC---EGHCVNTEGGFVCECGPGMQLSADRHSCQDTDECLGTP--CQQRCKNSIG 199
EC+ + G CVNT+G F C C G +L+ D +C D DEC T C N G
Sbjct: 578 ECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDG 637
Query: 200 SYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHS-CHNTVGSFLCTCRPGFRLRADR 258
S+KC C+ GF L N C DV+EC+ P +C + C N+ GSF C C PG + D
Sbjct: 638 SFKCICKPGFVLAPNGRYCTDVDECQTP---GICMNGHCINSEGSFRCDCPPGLAVGMDG 694
Query: 259 VSC 261
C
Sbjct: 695 RVC 697
Score = 110 bits (274), Expect = 8e-24
Identities = 74/228 (32%), Positives = 101/228 (44%), Gaps = 36/228 (15%)
Query: 53 CCPGWAPSMGGGH-CTL----------PLCSFGCGSGICIAPNVCSCQDGEQGAT-CPET 100
CC P G G C L LC +G G+ V S D + C E+
Sbjct: 2126 CCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGT-------VPSLHDTREDVNECLES 2178
Query: 101 HGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDEC-VTSSC-EGHCVNT 158
G C C T C+ CP+G+++ T G+RC D DEC + + C G C N
Sbjct: 2179 PGICSNGQCINTDGSFRCE-----CPMGYNLDYT--GVRCVDTDECSIGNPCGNGTCTNV 2231
Query: 159 EGGFVCECGPGMQLSADRHSCQDTDECLGTP--CQQRCKNSIGSYKCSCRTGFHLHGNRH 216
G F C C G + +C+D +EC P C RC N+ GSY+C+C G+ L ++
Sbjct: 2232 IGSFECNCNEGFE-PGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQK 2290
Query: 217 SCVDVNECRRPLERRVCHH---SCHNTVGSFLCTCRPGFRLRADRVSC 261
C D++EC L C C N +G+F+C C PG R D C
Sbjct: 2291 MCKDLDECAEGLHD--CESRGMMCKNLIGTFMCICPPGMARRPDGEGC 2336
Score = 106 bits (264), Expect = 1e-22
Identities = 71/206 (34%), Positives = 95/206 (46%), Gaps = 19/206 (9%)
Query: 64 GHCTLPLCSFGC--GSGICIAPNVCSCQDGEQGATCPETHGPCGEYGCDLTCNHGGCQEV 121
G C + SF C SG + +C D ++ P+ CG C T C E
Sbjct: 1087 GKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDL---CGSGICVNTPGSFEC-EC 1142
Query: 122 ARVCPVGFSMTETAVGIRCTDIDECVTSS--CEGH-CVNTEGGFVCECGPGMQLSADRHS 178
GF M + C DIDEC + C G CVNTEG F C+C G +LS R
Sbjct: 1143 FEGYESGFMMMKN-----CMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSRED 1197
Query: 179 CQDTDEC--LGTPCQQ-RCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHH 235
C D +EC C+ +C N IG+Y+CSC G+ +R C D++EC + C
Sbjct: 1198 CVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECM--IMNGGCDT 1255
Query: 236 SCHNTVGSFLCTCRPGFRLRADRVSC 261
C N+ GS+ C+C G+ L D SC
Sbjct: 1256 QCTNSEGSYECSCSEGYALMPDGRSC 1281
Score = 105 bits (261), Expect = 3e-22
Identities = 68/216 (31%), Positives = 98/216 (45%), Gaps = 30/216 (13%)
Query: 75 CGSGICIAPNVCSCQDGEQGATCPETHGPCGEYGCDLTCNHGGCQEVAR----VCPVGFS 130
C +G ++PN +C D + P C+HG C ++ +C GF
Sbjct: 1878 CAAGFKLSPNG-ACVDRNECLEIPNV------------CSHGLCVDLQGSYQCICHNGFK 1924
Query: 131 MTETAVGIRCTDIDECVTSSC-EGHCVNTEGGFVCECGPGMQLSADRHSCQDTDEC---L 186
++ C D+DEC C G C NT G + C C PG +L+ + + C D DEC
Sbjct: 1925 ASQDQT--MCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFELTHN-NDCLDIDECSSFF 1981
Query: 187 GTPCQQ-RCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFL 245
G C+ RC N IGS+KC C G+ L + +C+D NEC L +C N GSF
Sbjct: 1982 GQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVA-LPGSCSPGTCQNLEGSFR 2040
Query: 246 CTCRPGFRLRADRV----SCEAFPKAVLAPSAILQP 277
C C PG+ ++++ C+ P L S P
Sbjct: 2041 CICPPGYEVKSENCIDINECDEDPNICLFGSCTNTP 2076
Score = 103 bits (257), Expect = 8e-22
Identities = 84/289 (29%), Positives = 108/289 (37%), Gaps = 57/289 (19%)
Query: 27 RKPPGHFAAERR--RLGPHVCLSG--------FGSGCCPGWAPSMGGGHCT--------- 67
R+P G + R P +C +G + C G+ S G C
Sbjct: 2329 RRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFA 2388
Query: 68 ---LPLCSFGCGSGICIAPNVCSCQDGE----QGATCPET----------HGP-CGEYGC 109
+C S + + C C G Q CP HGP G
Sbjct: 2389 EVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGR 2448
Query: 110 DLT--------CNHGGCQEVAR----VCPVGFSMTETAVGIRCTDIDECVTSS--CEGHC 155
D+ C +G C C VG+ T G C D+DEC S C C
Sbjct: 2449 DIDECKVMPNLCTNGQCINTMGSFRCFCKVGY--TTDISGTSCIDLDECSQSPKPCNYIC 2506
Query: 156 VNTEGGFVCECGPGMQLSADRHSCQDTDECLGTP--CQQRCKNSIGSYKCSCRTGFHLHG 213
NTEG + C C G L D +C+D DEC CQ C N++G + C C GF H
Sbjct: 2507 KNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHH 2566
Query: 214 NRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTCRPGFRLRADRVSCE 262
+C+D NEC C NT GSF C C+ GF L A ++CE
Sbjct: 2567 T--ACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCE 2613
Score = 101 bits (252), Expect = 3e-21
Identities = 64/221 (28%), Positives = 97/221 (43%), Gaps = 30/221 (13%)
Query: 61 MGGGHCTLPLCSFGCGSGICIAPNVCSCQDGE----QGATCPETHGPCGEYGCDLTCNHG 116
+G C P F + + ++ C +G+ + A C + G Y C+
Sbjct: 1828 IGSFRCECPT-GFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPG---SYRCE------ 1877
Query: 117 GCQEVARVCPVGFSMTETAVGIRCTDIDEC--VTSSCE-GHCVNTEGGFVCECGPGMQLS 173
C GF ++ C D +EC + + C G CV+ +G + C C G + S
Sbjct: 1878 --------CAAGFKLSPNGA---CVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKAS 1926
Query: 174 ADRHSCQDTDECLGTPC-QQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRV 232
D+ C D DEC PC CKN++GSY C C GF L N + C+D++EC +
Sbjct: 1927 QDQTMCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFELTHN-NDCLDIDECSSFFGQVC 1985
Query: 233 CHHSCHNTVGSFLCTCRPGFRLRADRVSCEAFPKAVLAPSA 273
+ C N +GSF C C G+ L D +C + V P +
Sbjct: 1986 RNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGS 2026
Score = 100 bits (249), Expect = 6e-21
Identities = 66/210 (31%), Positives = 92/210 (43%), Gaps = 38/210 (18%)
Query: 46 LSGFGSGCCPGWAPSMGGGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGATCPETHGPCG 105
L GF C PG+ H T + + CGS P++C + C T G
Sbjct: 2551 LGGFTCKCPPGFTQ-----HHTACIDNNECGS----QPSLCGAK-----GICQNTPG--- 2593
Query: 106 EYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECVTSS-CEGHCVNTEGGFVC 164
+ C+ C GFS+ T G+ C D+DEC + C+ C N GG+ C
Sbjct: 2594 SFSCE--------------CQRGFSLDAT--GLNCEDVDECDGNHRCQHGCQNILGGYRC 2637
Query: 165 ECGPGMQLSADRHSCQDTDECLGTPC--QQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVN 222
C G + C D +EC C N++GSYKC+C +GF +C DVN
Sbjct: 2638 GCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVN 2697
Query: 223 ECRRPLERRVCHHSCHNTVGSFLCTCRPGF 252
EC + C++ C NT G +LC C PG+
Sbjct: 2698 ECSS--SKNPCNYGCSNTEGGYLCGCPPGY 2725
Score = 97.8 bits (242), Expect = 4e-20
Identities = 73/248 (29%), Positives = 100/248 (40%), Gaps = 50/248 (20%)
Query: 42 PHVCLSG--------FGSGCCPGWAPSMGGGHCT----LPLCSFGCGSGICIAP------ 83
P +C++G F C PG A M G C C G G+C+ P
Sbjct: 665 PGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVT 724
Query: 84 -NVCSCQD-----GEQGATCPETHGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVG 137
+ C C + GE CP + E+ HG C + G + E A+
Sbjct: 725 KSECCCANPDYGFGEPCQPCPAKNS--AEF-------HGLCSSGVGITVDGRDINECAL- 774
Query: 138 IRCTDIDECVTSSCEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDECLGTP--CQQR-C 194
D D C CE N G + C C G + A +C D DECL C C
Sbjct: 775 ----DPDICANGICE----NLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLC 826
Query: 195 KNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVC-HHSCHNTVGSFLCTCRPGFR 253
+N+ GSY C+C G+ +C D+NEC E C + +C N +GSF C C PG +
Sbjct: 827 RNTPGSYSCTCPPGYVFRTETETCEDINEC----ESNPCVNGACRNNLGSFNCECSPGSK 882
Query: 254 LRADRVSC 261
L + + C
Sbjct: 883 LSSTGLIC 890
Score = 97.4 bits (241), Expect = 5e-20
Identities = 66/207 (31%), Positives = 87/207 (42%), Gaps = 30/207 (14%)
Query: 75 CGSGICIAPNV---CSCQDGEQ----GATCPETH-----GPCGEYGCDLTCNHGGCQEVA 122
C +G CI + C C G G C +T PCG C C
Sbjct: 2182 CSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFECN--- 2238
Query: 123 RVCPVGFSMTETAVGIRCTDIDECVTSS--CEGHCVNTEGGFVCECGPGMQLSADRHSCQ 180
C GF E + C DI+EC + C C+NT G + C C G L D+ C+
Sbjct: 2239 --CNEGF---EPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCK 2293
Query: 181 DTDECLGT--PCQQR---CKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHH 235
D DEC C+ R CKN IG++ C C G + CVD NECR + +C +
Sbjct: 2294 DLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECR--TKPGICEN 2351
Query: 236 S-CHNTVGSFLCTCRPGFRLRADRVSC 261
C N +GS+ C C GF+ + C
Sbjct: 2352 GRCVNIIGSYRCECNEGFQSSSSGTEC 2378
Score = 96.3 bits (238), Expect = 1e-19
Identities = 65/193 (33%), Positives = 86/193 (44%), Gaps = 31/193 (16%)
Query: 86 CSCQDG--EQGATCPETHGPC--GEYGCDLTC---NHGGCQEVARVCPVGFSMTETAVGI 138
CSC++G G C + C G + C + N G A C GF T G
Sbjct: 1393 CSCREGWIGNGIKCIDLD-ECSNGTHQCSINAQCVNTPGSYRCA--CSEGF----TGDGF 1445
Query: 139 RCTDIDECVTSS--CE-GHCVNTEGGFVCECGPGMQLSADRHSCQDTDEC-------LGT 188
C+D+DEC + CE G C+N G + CEC G ++D SCQD DEC GT
Sbjct: 1446 TCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGT 1505
Query: 189 PCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTC 248
C N G + C C G+ L +C D++EC P+ + C NT G + C C
Sbjct: 1506 -----CNNLPGMFHCICDDGYELDRTGGNCTDIDECADPI--NCVNGLCVNTPGRYECNC 1558
Query: 249 RPGFRLRADRVSC 261
P F+L V C
Sbjct: 1559 PPDFQLNPTGVGC 1571
Score = 92.0 bits (227), Expect = 2e-18
Identities = 68/224 (30%), Positives = 88/224 (39%), Gaps = 37/224 (16%)
Query: 63 GGHCTLPLCSFGC-GSGICIAPNVCSCQDGEQGATCPETH--GPC----GEYGCD----- 110
G +C P+C GC G CI PN C+C G G C + GPC C
Sbjct: 172 GTYCGQPVCENGCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTG 231
Query: 111 ------LTCNHGG---------CQEVARVCPVGFSMTETAVGIRCTDIDEC--VTSSCEG 153
L C G C + C GF + G C D+DEC + C+G
Sbjct: 232 IVCTKTLCCATIGRAWGHPCEMCPAQPQPCRRGF-IPNIRTGA-CQDVDECQAIPGICQG 289
Query: 154 -HCVNTEGGFVCECGPGMQLSADRHSCQDTDECLGTP--CQQ-RCKNSIGSYKCSCRTGF 209
+C+NT G F C C G + S C+D DEC P C+ C N++GSY C C G+
Sbjct: 290 GNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGY 349
Query: 210 HLHGNRHSCVD--VNECRRPLERRVCHHSCHNTVGSFLCTCRPG 251
+ C+D C L C + C C PG
Sbjct: 350 VTSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPG 393
Score = 90.9 bits (224), Expect = 5e-18
Identities = 76/246 (30%), Positives = 106/246 (43%), Gaps = 40/246 (16%)
Query: 45 CLSGFGS---GCCPGWAPSMGGGHCT-LPLCSFG---CGSGICIAPNV-----CSCQDGE 92
C + GS C G+A G C + C C G C N+ C C DG
Sbjct: 1257 CTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCT--NIPGEYRCLCYDGF 1314
Query: 93 QGATCPETHGPCGEYGCDLT---CNHGGCQEVARV----CPVGFSMTETAVGIRCTDIDE 145
+ +T E CDL C G C+ C +G+S+ + G CTD+DE
Sbjct: 1315 MASMDMKTCIDVNE--CDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTG--CTDVDE 1370
Query: 146 CVTSS--CEGH--CVNTEGGFVCECGPGMQLSADRHSCQDTDECLGTPCQ----QRCKNS 197
C + C+ H C+N G F C C G + C D DEC Q +C N+
Sbjct: 1371 CEIGAHNCDMHASCLNIPGSFKCSCREGW--IGNGIKCIDLDECSNGTHQCSINAQCVNT 1428
Query: 198 IGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHS-CHNTVGSFLCTCRPGFRLRA 256
GSY+C+C GF G+ +C DV+EC + +C + C N G++ C C GF +
Sbjct: 1429 PGSYRCACSEGFT--GDGFTCSDVDECAENIN--LCENGQCLNVPGAYRCECEMGFTPAS 1484
Query: 257 DRVSCE 262
D SC+
Sbjct: 1485 DSRSCQ 1490
Score = 89.7 bits (221), Expect = 1e-17
Identities = 70/274 (25%), Positives = 103/274 (37%), Gaps = 94/274 (34%)
Query: 75 CGSGICIAPN---VCSCQDGEQ----GATCPETHGPCGEYGCDLTCNHGGC----QEVAR 123
C +G C+ + C C G + G C + H C C +G C
Sbjct: 586 CKNGRCVNTDGSFQCICNAGFELTTDGKNCVD-HDECTTTNM---CLNGMCINEDGSFKC 641
Query: 124 VCPVGFSMTETAVGIRCTDIDECVTSSC--EGHCVNTEGGFVCECGPGM------QLSAD 175
+C GF + G CTD+DEC T GHC+N+EG F C+C PG+ ++ D
Sbjct: 642 ICKPGFVLAPN--GRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVD 699
Query: 176 RHS---------------------------CQDTDECLGTPCQQR--------------- 193
H C + D G PCQ
Sbjct: 700 THMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSG 759
Query: 194 ------------------------CKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLE 229
C+N GSY+C+C +G+ + +C+D++EC +
Sbjct: 760 VGITVDGRDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECL--VN 817
Query: 230 RRVCHHS-CHNTVGSFLCTCRPGFRLRADRVSCE 262
R +C + C NT GS+ CTC PG+ R + +CE
Sbjct: 818 RLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCE 851
Score = 87.8 bits (216), Expect = 4e-17
Identities = 76/241 (31%), Positives = 98/241 (40%), Gaps = 35/241 (14%)
Query: 42 PHVCLSG--------FGSGCCPGWAPSMGGGHCT-LPLCSFG--CGSGIC---IAPNVCS 87
P +C +G F C G+ G C CS G CG+G C I C+
Sbjct: 2179 PGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFECN 2238
Query: 88 CQDG-EQGATCP-ETHGPCGEYG--CDLTC-NHGGCQEVARVCPVGFSMTETAVGIRCTD 142
C +G E G E C + C C N G E CP+G+++ E C D
Sbjct: 2239 CNEGFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECT--CPIGYALREDQK--MCKD 2294
Query: 143 IDECVTS--SCEGH---CVNTEGGFVCECGPGMQLSADRHSCQDTDECLGTP--CQQ-RC 194
+DEC CE C N G F+C C PGM D C D +EC P C+ RC
Sbjct: 2295 LDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRC 2354
Query: 195 KNSIGSYKCSCRTGFHLHGNRHSCVDVNE--CRRPLERRVCH--HSCHNTVGSFLCTCRP 250
N IGSY+C C GF + C+D + C + + +C S N V C C
Sbjct: 2355 VNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDG 2414
Query: 251 G 251
G
Sbjct: 2415 G 2415
Score = 86.7 bits (213), Expect = 1e-16
Identities = 65/222 (29%), Positives = 89/222 (40%), Gaps = 32/222 (14%)
Query: 42 PHVCLSGFGSGCCPGWAPSMGGGHCTLPLCSFGCGS-------GICIAPNVCSCQDGEQG 94
P L+ G GC G+C L G GS G+ ++ + C C G+
Sbjct: 1560 PDFQLNPTGVGCVDNRV-----GNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAW 1614
Query: 95 ATCPETHGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDEC--VTSSCE 152
PC TC E +CP G + I DIDEC + C+
Sbjct: 1615 GN------PCE------TCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQ 1662
Query: 153 G-HCVNTEGGFVCECGPGMQLSADRHSCQDTDECLGTP--C-QQRCKNSIGSYKCSCRTG 208
G +C+NT G F CEC G LS D C+D DEC P C C N++G+Y C C
Sbjct: 1663 GGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPE 1722
Query: 209 FHLHGNRHSCVDVNE--CRRPLERRVCHHSCHNTVGSFLCTC 248
+ H+C+D+ + C R C + V +C C
Sbjct: 1723 YMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCC 1764
Score = 72.8 bits (177), Expect = 1e-12
Identities = 72/271 (26%), Positives = 98/271 (36%), Gaps = 62/271 (22%)
Query: 46 LSGFGSGCCPGWAPSMGGGHCTLPLCSFGCGSGIC-IAPNVCSCQDGEQGAT----CPET 100
L F C PG S G C L G C + C+ GAT C T
Sbjct: 870 LGSFNCECSPGSKLSSTGLICIDSL------KGTCWLNIQDSRCEVNINGATLKSECCAT 923
Query: 101 HGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECVT--SSC-EGHCVN 157
G C+ E+ CP G + + G+ C D++EC C G CVN
Sbjct: 924 LGAAWGSPCERC-------ELDTACPRGLARIK---GVTCEDVNECEVFPGVCPNGRCVN 973
Query: 158 TEGGFVCECGPGMQLSADRHSCQDT-----------DECL-------------------- 186
++G F CEC G+ L C D DEC+
Sbjct: 974 SKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAVGAAW 1033
Query: 187 GTPCQQRCKNSIGSYKCSCR--TGFHLHGN----RHSCVDVNECRRPLERRVCHHSCHNT 240
GT C++ K Y+ C GF G+ R D+NEC+ + C NT
Sbjct: 1034 GTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKA-FPGMCTYGKCRNT 1092
Query: 241 VGSFLCTCRPGFRLRADRVSCEAFPKAVLAP 271
+GSF C C GF L + +C + ++P
Sbjct: 1093 IGSFKCRCNSGFALDMEERNCTDIDECRISP 1123
Score = 72.8 bits (177), Expect = 1e-12
Identities = 80/285 (28%), Positives = 105/285 (36%), Gaps = 71/285 (24%)
Query: 36 ERRRLGPHVCLSGFGSG---CCPGWAPSMGGGHCTLPLCS--FG--CGSGIC---IAPNV 85
ER G C + GS C PG+ + + CS FG C +G C I
Sbjct: 1939 ERHPCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFK 1998
Query: 86 CSCQDGEQ----GATCPETHGPCGEYGCDLTCNHGGCQEVAR----VCPVGFSMTETAVG 137
C C +G + G C +T+ G +C+ G CQ + +CP G+ +
Sbjct: 1999 CLCNEGYELTPDGKNCIDTNECVALPG---SCSPGTCQNLEGSFRCICPPGYEVKSE--- 2052
Query: 138 IRCTDIDECVTSS---CEGHCVNTEGGFVCECGPGMQLSADRHSCQDT------------ 182
C DI+EC G C NT GGF C C PG LS + C DT
Sbjct: 2053 -NCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENG 2111
Query: 183 ---------------------DECLGTPCQQRCKNSIGSYKCSCRTGF----HLHGNRHS 217
E G PC+ K+ +++ C G LH R
Sbjct: 2112 KCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTRE- 2170
Query: 218 CVDVNECRRPLERRVCHH-SCHNTVGSFLCTCRPGFRLRADRVSC 261
DVNEC +C + C NT GSF C C G+ L V C
Sbjct: 2171 --DVNECLE--SPGICSNGQCINTDGSFRCECPMGYNLDYTGVRC 2211
Score = 67.4 bits (163), Expect = 6e-11
Identities = 82/328 (25%), Positives = 110/328 (33%), Gaps = 106/328 (32%)
Query: 48 GFGSGCCPGWAPSMGGGHCTLPLCSFGCGSGI--------CIAPNVCS---CQD--GEQG 94
GFG C P A + H LCS G G + + P++C+ C++ G
Sbjct: 736 GFGEPCQPCPAKNSAEFH---GLCSSGVGITVDGRDINECALDPDICANGICENLRGSYR 792
Query: 95 ATCPETHGP--CGEYGCD--------LTCNHGGCQEV----ARVCPVGFSM-TETAVGIR 139
C + P G D L C++G C+ + CP G+ TET
Sbjct: 793 CNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETET--- 849
Query: 140 CTDIDECVTSSC-EGHCVNTEGGFVCECGPGMQLSADRHSCQDT---------------- 182
C DI+EC ++ C G C N G F CEC PG +LS+ C D+
Sbjct: 850 CEDINECESNPCVNGACRNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEV 909
Query: 183 --------DECL-------GTPCQQ----------------------------------- 192
EC G+PC++
Sbjct: 910 NINGATLKSECCATLGAAWGSPCERCELDTACPRGLARIKGVTCEDVNECEVFPGVCPNG 969
Query: 193 RCKNSIGSYKCSCRTGFHLHGNRHSCVDV--NECRRPLERRVCHHSCHNTVGSFLCTCRP 250
RC NS GS+ C C G L G C+D+ +C + C H C C
Sbjct: 970 RCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAV 1029
Query: 251 GFRLRADRVSCEAFPKAVLAPSAILQPR 278
G A CE PK L PR
Sbjct: 1030 G---AAWGTECEECPKPGTKEYETLCPR 1054
Score = 63.9 bits (154), Expect = 7e-10
Identities = 60/212 (28%), Positives = 82/212 (38%), Gaps = 40/212 (18%)
Query: 52 GCCPGW--APSMGGGHCTLPLCSFGCGSG-ICIAPNVCSCQDGEQGATCPETHGPCGEYG 108
G CP S G HC P G+G +C+ + C C H G++
Sbjct: 964 GVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDEC--IHPVPGKFR 1021
Query: 109 CDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECVTSSCEGHCVNTEGGFVCECGP 168
D C C VG A G C + + T E +C G
Sbjct: 1022 MDACC-----------CAVG-----AAWGTECEECPKPGTKEYET---------LCPRGA 1056
Query: 169 GMQLSAD----RHSCQDTDECLGTP---CQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDV 221
G D R +D +EC P +C+N+IGS+KC C +GF L +C D+
Sbjct: 1057 GFANRGDVLTGRPFYKDINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDI 1116
Query: 222 NECRRPLERRVCHHS-CHNTVGSFLCTCRPGF 252
+ECR + +C C NT GSF C C G+
Sbjct: 1117 DECR--ISPDLCGSGICVNTPGSFECECFEGY 1146
Score = 63.9 bits (154), Expect = 7e-10
Identities = 61/244 (25%), Positives = 84/244 (34%), Gaps = 50/244 (20%)
Query: 75 CGSGICI-APNV--CSCQDGEQGATCPETHGPCGEYGCDLTCNHGGCQEVAR----VCPV 127
C +G C+ P C C+ G A+ + E C G C + +C
Sbjct: 1460 CENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDD 1519
Query: 128 GFSMTETAVGIRCTDIDECVT--SSCEGHCVNTEGGFVCECGPGMQLSADRHSCQDT--- 182
G+ + T G CTDIDEC + G CVNT G + C C P QL+ C D
Sbjct: 1520 GYELDRT--GGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVG 1577
Query: 183 ---------------------------------DECLGTPCQQRCKNSIGSYKCSCRTGF 209
+ G PC+ + Y C G
Sbjct: 1578 NCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGE 1637
Query: 210 HLHGNRHSCV--DVNECRRPLERRVCHHSCHNTVGSFLCTCRPGFRLRADRVSCEAFPKA 267
N + + D++EC+ L +C NT GSF C C G+ L D CE +
Sbjct: 1638 GFRPNPITIILEDIDECQE-LPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDEC 1696
Query: 268 VLAP 271
P
Sbjct: 1697 FAHP 1700
Score = 61.6 bits (148), Expect = 3e-09
Identities = 61/238 (25%), Positives = 84/238 (35%), Gaps = 35/238 (14%)
Query: 63 GGHCTLPLCSFGCG--SGICIAPNVCSCQDGEQGATCPETHGP------CGEYGCD---- 110
GG+C SF C G ++ + C+D ++ P GP G Y C
Sbjct: 1663 GGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPE 1722
Query: 111 -LTCNHG-GCQEVAR----------VCPVGFSMTETAVGIRCT-DIDECVTSSCEGHCVN 157
+ N G C ++ + C T CT ++ + CE
Sbjct: 1723 YMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTP 1782
Query: 158 TEGGFVCECG--PGMQLSADRHSCQDTDECLGTP---CQQRCKNSIGSYKCSCRTGFHLH 212
F CG PG D DEC P C N IGS++C C TGF +
Sbjct: 1783 GTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYN 1842
Query: 213 GNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTCRPGFRLR-----ADRVSCEAFP 265
C D++EC + C N+ GS+ C C GF+L DR C P
Sbjct: 1843 DLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNGACVDRNECLEIP 1900
Score = 35.8 bits (81), Expect = 0.20
Identities = 48/202 (23%), Positives = 66/202 (32%), Gaps = 53/202 (26%)
Query: 480 CPSGPCQTPPQTDCCTCVPVRCYFHGRWYADGAVFSGGGDECTTCVCQN--GEVECSFMP 537
C +G C+ P + CTC P F + + C C+N G C P
Sbjct: 821 CDNGLCRNTPGSYSCTC-PPGYVFRTETETCEDINECESNPCVNGACRNNLGSFNCECSP 879
Query: 538 CPELACPREEWRLGPGQCCF-----TCQEPTPSTGCSLDDNGVEF------PIGQIWSPG 586
+L+ G C TC + C ++ NG +G W G
Sbjct: 880 GSKLS--------STGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAW--G 929
Query: 587 DPCELCICQADGSVSCKRTDCVDSCPHPI-RIPGQCCPDCSAGCTYTGRIFYNNETFPSV 645
PCE C + +CP + RI G C D + E FP V
Sbjct: 930 SPCERC-------------ELDTACPRGLARIKGVTCEDVN-----------ECEVFPGV 965
Query: 646 LDPCLSCICLLGSVACSPVDCP 667
P C+ GS C +CP
Sbjct: 966 C-PNGRCVNSKGSFHC---ECP 983
>gi|10190748 CEGP1 protein [Homo sapiens]
Length = 999
Score = 120 bits (302), Expect = 5e-27
Identities = 72/188 (38%), Positives = 91/188 (48%), Gaps = 21/188 (11%)
Query: 84 NVCSCQDGEQGA-------TCPETHGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAV 136
N S DG++ TC +G GCD TC V CPVGF++
Sbjct: 266 NTTSVVDGDKRVKRRLLMETCAVNNG-----GCDRTCKDTSTG-VHCSCPVGFTLQLD-- 317
Query: 137 GIRCTDIDECVTSS--CEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDEC-LGTPCQQR 193
G C DIDEC T + C+ C N G F C C G +L D SCQD DEC L C
Sbjct: 318 GKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDHS 377
Query: 194 CKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTCRPGFR 253
C N G++ C+C G+ L+G H C D NEC + C C NTVGS+ C C PG++
Sbjct: 378 CINHPGTFACACNRGYTLYGFTH-CGDTNEC--SINNGGCQQVCVNTVGSYECQCHPGYK 434
Query: 254 LRADRVSC 261
L ++ C
Sbjct: 435 LHWNKKDC 442
Score = 102 bits (255), Expect = 1e-21
Identities = 53/135 (39%), Positives = 69/135 (51%), Gaps = 12/135 (8%)
Query: 137 GIRCTDIDEC---VTSSCEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDECLGTP--CQ 191
G +C DIDEC + C C+N G + C C G L+ D H+C D DECL CQ
Sbjct: 81 GRQCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQ 140
Query: 192 QRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNE----CRRPLERRVCHHSCHNTV-GSFLC 246
C N +GSY+C C+ GF L N+H+C+ +E C + C H C GS C
Sbjct: 141 HTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMN--KDHGCSHICKEAPRGSVAC 198
Query: 247 TCRPGFRLRADRVSC 261
CRPGF L ++ C
Sbjct: 199 ECRPGFELAKNQRDC 213
Score = 94.0 bits (232), Expect = 6e-19
Identities = 83/272 (30%), Positives = 115/272 (42%), Gaps = 35/272 (12%)
Query: 37 RRRLGPHVCLSGFGSGCCPGWAPSMGGGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGAT 96
+RRL C G GC + G HC+ P+ G + + +C+D ++
Sbjct: 278 KRRLLMETCAVNNG-GCDRTCKDTSTGVHCSCPV-------GFTLQLDGKTCKDIDE--- 326
Query: 97 CPETHGPCGEYGCDLTC-NHGGCQEVARVCPVGFSMTETAVGIRCTDIDEC-VTSSCEGH 154
C +G GCD C N G + C GF + C D+DEC + +C+
Sbjct: 327 CQTRNG-----GCDHFCKNIVGSFDCG--CKKGFKLLTDEKS--CQDVDECSLDRTCDHS 377
Query: 155 CVNTEGGFVCECGPGMQLSADRHSCQDTDECL--GTPCQQRCKNSIGSYKCSCRTGFHLH 212
C+N G F C C G L H C DT+EC CQQ C N++GSY+C C G+ LH
Sbjct: 378 CINHPGTFACACNRGYTLYGFTH-CGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLH 436
Query: 213 GNRHSCVDVNE-CRRPLERRVCHHSCHNTVGSFLC--TCRPGFRLRADRVSCEAFPKAVL 269
N+ CV+V + RV H C + G C C G L +D +
Sbjct: 437 WNKKDCVEVKGLLPTSVSPRVSLH-CGKSGGGDGCFLRCHSGIHLSSDVTTIRT------ 489
Query: 270 APSAILQPRQHPSKMLLLLPEAGRPALSPGHS 301
+ + L + K L PE RPAL HS
Sbjct: 490 SVTFKLNEGKCSLKNAELFPEGLRPALPEKHS 521
Score = 92.4 bits (228), Expect = 2e-18
Identities = 47/127 (37%), Positives = 66/127 (51%), Gaps = 11/127 (8%)
Query: 142 DIDECVTSSCEGH----CVNTEGGFVCECGPGMQLSADRHSCQDTDEC---LGTPCQQRC 194
D+DEC + H C NT + C C PG Q + C+D DEC L C C
Sbjct: 45 DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQ--GEGRQCEDIDECGNELNGGCVHDC 102
Query: 195 KNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTCRPGFRL 254
N G+Y+C+C GF L + H+C+DV+EC C H+C N +GS+ C C+ GF L
Sbjct: 103 LNIPGNYRCTCFDGFMLAHDGHNCLDVDECLE--NNGGCQHTCVNVMGSYECCCKEGFFL 160
Query: 255 RADRVSC 261
++ +C
Sbjct: 161 SDNQHTC 167
Score = 65.1 bits (157), Expect = 3e-10
Identities = 62/268 (23%), Positives = 102/268 (38%), Gaps = 55/268 (20%)
Query: 30 PGHFAAERRRLGPHVCLSGFGSGCCPGWAPSMGGGHCTLPLCSFGCGSGICIAPNVCSCQ 89
PG+ R+ C + GC G CT C G +A + +C
Sbjct: 75 PGYQGEGRQCEDIDECGNELNGGCVHDCLNIPGNYRCT-------CFDGFMLAHDGHNCL 127
Query: 90 DGEQGATCPETHGPCGEYGCDLTC-NHGGCQEVARVCPVGFSMTE--------TAVGIRC 140
D ++ C E +G GC TC N G E C GF +++ + G+ C
Sbjct: 128 DVDE---CLENNG-----GCQHTCVNVMGSYECC--CKEGFFLSDNQHTCIHRSEEGLSC 177
Query: 141 TDIDECVTSSCEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDECLGTPCQQRCKNSIGS 200
+ D + C+ G CEC PG +L+ ++ C T CQ C ++
Sbjct: 178 MNKDHGCSHICKEA---PRGSVACECRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADG 234
Query: 201 YKCSCRTGFHLHGNRHSCVD---------------VNECRRPLERRV-----------CH 234
+CSC + +H + SC++ V + + ++RR+ C
Sbjct: 235 PECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCD 294
Query: 235 HSCHNTVGSFLCTCRPGFRLRADRVSCE 262
+C +T C+C GF L+ D +C+
Sbjct: 295 RTCKDTSTGVHCSCPVGFTLQLDGKTCK 322
Score = 60.5 bits (145), Expect = 7e-09
Identities = 32/86 (37%), Positives = 42/86 (48%), Gaps = 7/86 (8%)
Query: 180 QDTDECL----GTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHH 235
+D DEC C+N+ SYKCSC+ G+ G C D++EC L C H
Sbjct: 44 EDVDECAQGLDDCHADALCQNTPTSYKCSCKPGY--QGEGRQCEDIDECGNELNGG-CVH 100
Query: 236 SCHNTVGSFLCTCRPGFRLRADRVSC 261
C N G++ CTC GF L D +C
Sbjct: 101 DCLNIPGNYRCTCFDGFMLAHDGHNC 126
>gi|56237021 fibrillin 3 precursor [Homo sapiens]
Length = 2809
Score = 120 bits (302), Expect = 5e-27
Identities = 72/196 (36%), Positives = 91/196 (46%), Gaps = 24/196 (12%)
Query: 86 CSCQDGEQGATCPETHG------PCGEYG-CDLT---CNHGGCQEVARV----CPVGFSM 131
C+ DG CP H C + C L+ C HG C V C GF
Sbjct: 1087 CTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQS 1146
Query: 132 TETAVGIRCTDIDECVTSS--CEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDECLGTP 189
T G C DI+EC + C+ HC+NTEG + C CG G L D +C D DEC P
Sbjct: 1147 TPDRQG--CVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENP 1204
Query: 190 --CQQ-RCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVC-HHSCHNTVGSFL 245
C Q C N G ++C C GF + +CVDV+EC L +C H C NT GSF+
Sbjct: 1205 RVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDEC--DLNPHICLHGDCENTKGSFV 1262
Query: 246 CTCRPGFRLRADRVSC 261
C C+ G+ +R C
Sbjct: 1263 CHCQLGYMVRKGATGC 1278
Score = 118 bits (295), Expect = 3e-26
Identities = 93/275 (33%), Positives = 113/275 (41%), Gaps = 44/275 (16%)
Query: 11 CVALLLPGAPARGYTGRKPPGH-FAAERR-----RLGPHVCLSG--------FGSGCCPG 56
C LPG A Y P G + AE R R+ H+C G F C G
Sbjct: 2336 CELCPLPGTSA--YRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAG 2393
Query: 57 WAPSMGGGHCT-------LPL-CSFGCGSGICIAPNVCSCQDG----EQGATCPETHGPC 104
+ P C +P C+F C + +CSC G E G TC +
Sbjct: 2394 YTPDATATTCLDMDECSQVPKPCTFLCKN--TKGSFLCSCPRGYLLEEDGRTCKDLDECT 2451
Query: 105 G-EYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECVTS----SCEGHCVNTE 159
++ C C + R CP GF+ A C D DEC GHC NT
Sbjct: 2452 SRQHNCQFLCVNTVGAFTCR-CPPGFTQHHQA----CFDNDECSAQPGPCGAHGHCHNTP 2506
Query: 160 GGFVCECGPGMQLSADRHSCQDTDECLGTP-CQQRCKNSIGSYKCSCRTGFHLHGNRHSC 218
G F CEC G L + H C+D +EC G CQ C+N +G Y+CSC GF H C
Sbjct: 2507 GSFRCECHQGFTLVSSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQC 2566
Query: 219 VDVNECRRPLERRVC-HHSCHNTVGSFLCTCRPGF 252
VD NEC L C SC NT+G F C C GF
Sbjct: 2567 VDENEC--ALSPPTCGSASCRNTLGGFRCVCPSGF 2599
Score = 117 bits (293), Expect = 5e-26
Identities = 153/571 (26%), Positives = 198/571 (34%), Gaps = 123/571 (21%)
Query: 41 GPHVCLSGFGSGCCPGWAPSMGGGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGATCPET 100
GP+VC S F + CCPGW G C +P+C CG G C PN+C+C DG +C +
Sbjct: 56 GPNVCGSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVS 115
Query: 101 HGPCGEYGCDLTCNHGG-CQEVARVCPVGFSMTETAV---------GIRCTDIDECV--- 147
G GC ++C +GG C+ + +C G++ T G RC + C
Sbjct: 116 RGS----GCSVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVY 171
Query: 148 ------------TSSCEGH-------------------CVNTEG---GFVCE-------- 165
T C G C T G G CE
Sbjct: 172 GFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHP 231
Query: 166 CGPGMQLSADRHSCQDTDECLGTP--CQ-QRCKNSIGSYKCSCRTGFHLHGNRHSCVD-- 220
C G + +CQD DEC P CQ C N +GS+ C C G L + +C D
Sbjct: 232 CRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYR 291
Query: 221 VNECRRPLERRVCHHSCHNTVGSFLCTCRPGFRLRADRVSCEAFPKA--VLAPSAILQPR 278
C L C C C DR C A + P + +
Sbjct: 292 AGACFSVLFGGRCAGDLAGHYTRRQCCC--------DRGRCWAAGPVPELCPPRGSNEFQ 343
Query: 279 QHPSKMLLLLPEAGRPALSPG-HSPPSGAPGPPAG-VRTTRLPSPTPRLPTSSPSAPVWL 336
Q ++ L LLP G P L PG S GPP G R S +P+ P
Sbjct: 344 QLCAQRLPLLP--GHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIG 401
Query: 337 LSTLLATPVPTASLLGNLRPPSLLQGEVMGTPSS------------PRGPESPRLAAGPS 384
+TL T + NL L G + TPSS RG S
Sbjct: 402 TATLNQT-IDICRHFTNL----CLNGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSS 456
Query: 385 PCWHLGAMHESRSRWTEPGCSQCWCEDG-KVTCEKVRC----EAACSHPIPSRDGGCCPS 439
PC H ++ PG C C G + T + C E S + G C +
Sbjct: 457 PCHHGDCVN-------IPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHL--GRCVN 507
Query: 440 CTGCFHSGVVRAEGDVFSPPNENCTVCVCLAGNVSCISPECPSGPCQTPPQTDCCTCVPV 499
G F V G SP +N C+ N S C +G C + C C P
Sbjct: 508 TEGSFQ--CVCNAGFELSPDGKN-----CVDHNECATSTMCVNGVCLNEDGSFSCLCKP- 559
Query: 500 RCYFHGRWYADGAVFSGGGDEC-TTCVCQNG 529
G A G + DEC T +C NG
Sbjct: 560 -----GFLLAPGGHYCMDIDECQTPGICVNG 585
Score = 114 bits (285), Expect = 4e-25
Identities = 80/236 (33%), Positives = 104/236 (44%), Gaps = 23/236 (9%)
Query: 42 PHVCLSG--------FGSGCCPGWAPSMGGGHC---TLPLCSFGCGSGICIAPNVCSCQD 90
P++CL G F C PG+ S G C C +G C P +
Sbjct: 1977 PNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTT- 2035
Query: 91 GEQGATCPETHGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECVTSS 150
+ C + G C+L C G +CP G R D++EC +
Sbjct: 2036 -KTRCCCSKRPGEGWGDPCEL-CPQEGSAAFQELCPFGHGAVPGPDDSR-EDVNECAENP 2092
Query: 151 ---CEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDEC-LGTPCQQ-RCKNSIGSYKCSC 205
G CVNT+G F CEC G L +C DTDEC +G PC Q C N IG ++C+C
Sbjct: 2093 GVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECAC 2152
Query: 206 RTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTCRPGFRLRADRVSC 261
GF G +C D++EC L +C CHNT GS+LCTC G+ LR D C
Sbjct: 2153 ADGFE-PGLMMTCEDIDECS--LNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMC 2205
Score = 112 bits (281), Expect = 1e-24
Identities = 90/274 (32%), Positives = 115/274 (41%), Gaps = 48/274 (17%)
Query: 15 LLPGAPARGYTGRKPPGHFAAERRRLGPHVCLSGFGSGCCPGWAPSMGGGHC-------- 66
L PG G G PP A RL PH G PS+G G+
Sbjct: 359 LFPGLLGFGSNGMGPPLGPA----RLNPH--------GSDARGIPSLGPGNSNIGTATLN 406
Query: 67 -TLPLCSFG---CGSGICI---APNVCSCQDGEQGATCPETHGPCGEYG--CDLTCNHGG 117
T+ +C C +G C+ + C C G + G C + C+HG
Sbjct: 407 QTIDICRHFTNLCLNGRCLPTPSSYRCECNVGYT----QDVRGECIDVDECTSSPCHHGD 462
Query: 118 CQEVARV----CPVGFSMTETAVGIRCTDIDECVTSS--CE-GHCVNTEGGFVCECGPGM 170
C + C GF T T C D+DEC+ S C G CVNTEG F C C G
Sbjct: 463 CVNIPGTYHCRCYPGFQATPTRQA--CVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGF 520
Query: 171 QLSADRHSCQDTDEC-LGTPCQQR-CKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPL 228
+LS D +C D +EC T C C N GS+ C C+ GF L H C+D++EC+ P
Sbjct: 521 ELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTP- 579
Query: 229 ERRVC-HHSCHNTVGSFLCTCRPGFRLRADRVSC 261
+C + C NT GSF C C G + D C
Sbjct: 580 --GICVNGHCTNTEGSFRCQCLGGLAVGTDGRVC 611
Score = 111 bits (278), Expect = 3e-24
Identities = 67/208 (32%), Positives = 98/208 (47%), Gaps = 24/208 (11%)
Query: 60 SMGGGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGATCPETHGPCGEYGCDLTCNHGGCQ 119
++G HC C G + +C D ++ P+ CG+ C T C+
Sbjct: 1005 TVGSFHCA-------CAGGFALDAQERNCTDIDECRISPDL---CGQGTCVNTPGSFECE 1054
Query: 120 EVARVCPVGFSMTETAVGIRCTDIDECVTSS--CEGH-CVNTEGGFVCECGPGMQLSADR 176
C G+ + C D+DEC C G C NT+G + C+C PG +L+A
Sbjct: 1055 -----CFPGYESGFMLMK-NCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKG 1108
Query: 177 HSCQDTDECL---GTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVC 233
+C+D DEC G +C N IG+++CSC GF +R CVD+NECR ++ C
Sbjct: 1109 TACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECR--VQNGGC 1166
Query: 234 HHSCHNTVGSFLCTCRPGFRLRADRVSC 261
C NT GS+ C+C G+ L D +C
Sbjct: 1167 DVHCINTEGSYRCSCGQGYSLMPDGRAC 1194
Score = 109 bits (272), Expect = 1e-23
Identities = 83/249 (33%), Positives = 100/249 (40%), Gaps = 23/249 (9%)
Query: 46 LSGFGSGCCPGWAPSMGGGHCT-LPLCSFG---CGSGICI---APNVCSCQDG-EQGATC 97
+ F C G+A +CT + C CG G C+ C C G E G
Sbjct: 1006 VGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFML 1065
Query: 98 PETHGPCGEYGCD-LTCNHGGCQEVARV----CPVGFSMTETAVGIRCTDIDECVTSS-- 150
+ E D L C G C CP G +T A G C DIDEC S
Sbjct: 1066 MKNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELT--AKGTACEDIDECSLSDGL 1123
Query: 151 C-EGHCVNTEGGFVCECGPGMQLSADRHSCQDTDECL--GTPCQQRCKNSIGSYKCSCRT 207
C G CVN G F C C G Q + DR C D +EC C C N+ GSY+CSC
Sbjct: 1124 CPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQ 1183
Query: 208 GFHLHGNRHSCVDVNECRRPLERRVCHHS-CHNTVGSFLCTCRPGFRLRADRVSCEAFPK 266
G+ L + +C DV+EC RVC C N G C C GF D +C +
Sbjct: 1184 GYSLMPDGRACADVDECEE--NPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDE 1241
Query: 267 AVLAPSAIL 275
L P L
Sbjct: 1242 CDLNPHICL 1250
Score = 107 bits (266), Expect = 7e-23
Identities = 74/204 (36%), Positives = 97/204 (47%), Gaps = 32/204 (15%)
Query: 83 PNVCS---CQDGEQGATCPETHG--------PCGEYG-CDLT-CNHGGCQEVAR----VC 125
PNVCS C D E C G C + CD C +G C+ + +C
Sbjct: 1813 PNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGTCKNIIGSYNCLC 1872
Query: 126 PVGFSMTETAVGIRCTDIDECVT---SSCE-GHCVNTEGGFVCECGPGMQLSADRHSCQD 181
GF +T C D DEC T C GHC+NT G F C C G +L+AD +C D
Sbjct: 1873 FPGFVVTHNG---DCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVD 1929
Query: 182 TDECL---GTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVC-HHSC 237
T+ECL GT C+N GS++C C GF + + C+D++EC E +C +C
Sbjct: 1930 TNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDH--CIDIDECSE--EPNLCLFGTC 1985
Query: 238 HNTVGSFLCTCRPGFRLRADRVSC 261
N+ GSF C C PGF L + C
Sbjct: 1986 TNSPGSFQCLCPPGFVLSDNGHRC 2009
Score = 104 bits (260), Expect = 3e-22
Identities = 59/158 (37%), Positives = 73/158 (46%), Gaps = 12/158 (7%)
Query: 113 CNHGGCQEVARV----CPVGFSMTETAVGIRCTDIDEC--VTSSCEGHCVNTEGGFVCEC 166
C HG C C G++ TA C D+DEC V C C NT+G F+C C
Sbjct: 2374 CAHGECINSLGSFRCHCQAGYTPDATAT--TCLDMDECSQVPKPCTFLCKNTKGSFLCSC 2431
Query: 167 GPGMQLSADRHSCQDTDECLGTP--CQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNEC 224
G L D +C+D DEC CQ C N++G++ C C GF H +C D +EC
Sbjct: 2432 PRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQH--HQACFDNDEC 2489
Query: 225 RRPLERRVCHHSCHNTVGSFLCTCRPGFRLRADRVSCE 262
H CHNT GSF C C GF L + CE
Sbjct: 2490 SAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCE 2527
Score = 103 bits (257), Expect = 8e-22
Identities = 74/206 (35%), Positives = 93/206 (45%), Gaps = 29/206 (14%)
Query: 75 CGSGICI---APNVCSCQDG----------EQGATCPETHGPCGEYG-CDLTCNHGGCQE 120
C +GICI C C G E C PC + C C+
Sbjct: 1732 CANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCK- 1790
Query: 121 VARVCPVGFSMTETAVGIRCTDIDEC--VTSSCE-GHCVNTEGGFVCECGPGMQLSADRH 177
C G+ ++ G C +EC + + C G C++TEG ++C C G Q SAD+
Sbjct: 1791 ----CTRGYKLSP---GGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQT 1843
Query: 178 SCQDTDECLGTPC-QQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHS 236
C D DEC PC CKN IGSY C C GF + N CVD +EC L +VC
Sbjct: 1844 LCMDIDECDRQPCGNGTCKNIIGSYNCLCFPGFVVTHN-GDCVDFDEC-TTLVGQVCRFG 1901
Query: 237 -CHNTVGSFLCTCRPGFRLRADRVSC 261
C NT GSF C C+ GF L AD +C
Sbjct: 1902 HCLNTAGSFHCLCQDGFELTADGKNC 1927
Score = 100 bits (248), Expect = 8e-21
Identities = 71/226 (31%), Positives = 99/226 (43%), Gaps = 45/226 (19%)
Query: 53 CCPGWAPSMGGGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGATCPETHGPCGEYGCDLT 112
C G +M GGH L C G P++ +C D ++ CDL
Sbjct: 1207 CDQGHCTNMPGGHRCL------CYDGFMATPDMRTCVDVDE---------------CDLN 1245
Query: 113 ---CNHGGCQEVARV----CPVGFSMTETAVGIRCTDIDECVTS--SCEGH--CVNTEGG 161
C HG C+ C +G+ + + A G C+D+DEC +C+ H C+N G
Sbjct: 1246 PHICLHGDCENTKGSFVCHCQLGYMVRKGATG--CSDVDECEVGGHNCDSHASCLNIPGS 1303
Query: 162 FVCECGPGMQLSADRHSCQDTDECLGTP--CQQR--CKNSIGSYKCSCRTGFHLHGNRHS 217
F C C PG D C D DEC+ C R C N GSY+C+CR GF G+
Sbjct: 1304 FSCRCLPGWV--GDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFA--GDGFF 1359
Query: 218 CVDVNECRRPLERRVCHHS-CHNTVGSFLCTCRPGFRLRADRVSCE 262
C D +EC ++ +C + C N G + C C GF D +C+
Sbjct: 1360 CEDRDECAENVD--LCDNGQCLNAPGGYRCECEMGFDPTEDHRACQ 1403
Score = 98.6 bits (244), Expect = 2e-20
Identities = 79/239 (33%), Positives = 96/239 (40%), Gaps = 36/239 (15%)
Query: 46 LSGFGSGCCPGWAPSM--------GGGHCTLPLCSFGCGSGICIAP-------NVCSCQD 90
L FG G PG S G CT +C GS C P +C D
Sbjct: 2067 LCPFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVD 2126
Query: 91 GEQGATCPETHGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECVTSS 150
++ C H PCG+ C C C GF E + + C DIDEC +
Sbjct: 2127 TDE---CSVGH-PCGQGTCTNVIGGFEC-----ACADGF---EPGLMMTCEDIDECSLNP 2174
Query: 151 --CEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDECLG--TPCQQR---CKNSIGSYKC 203
C C NTEG ++C C G L D C+D DEC C R CKN IG++ C
Sbjct: 2175 LLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFAC 2234
Query: 204 SCRTGFH-LHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTCRPGFRLRADRVSC 261
C G L G+ C D NEC + V + C NT GSF C C GF+ C
Sbjct: 2235 VCPPGMRPLPGSGEGCTDDNECHAQPDLCV-NGRCVNTAGSFRCDCDEGFQPSPTLTEC 2292
Score = 98.2 bits (243), Expect = 3e-20
Identities = 80/252 (31%), Positives = 105/252 (41%), Gaps = 41/252 (16%)
Query: 40 LGPHVCLSG--------FGSGCCPGWAPSMGGGHCT-LPLCSFG---CGS-GICIAPNV- 85
L PH+CL G F C G+ G C+ + C G C S C+ N+
Sbjct: 1244 LNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCL--NIP 1301
Query: 86 ----CSCQDG--EQGATCPETHGPCG-EYGCDLTCNHGGCQEVAR----VCPVGFSMTET 134
C C G G C + E+ C G C V C GF+
Sbjct: 1302 GSFSCRCLPGWVGDGFECHDLDECVSQEHRCS---PRGDCLNVPGSYRCTCRQGFA---- 1354
Query: 135 AVGIRCTDIDECVTSS--CE-GHCVNTEGGFVCECGPGMQLSADRHSCQDTDECL-GTPC 190
G C D DEC + C+ G C+N GG+ CEC G + D +CQD DEC G C
Sbjct: 1355 GDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLC 1414
Query: 191 Q-QRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTCR 249
C+N G ++C C G+ L +C D+NEC P+ + C NT GS+LC+C
Sbjct: 1415 AFGSCENLPGMFRCICNGGYELDRGGGNCTDINECADPV--NCINGVCINTPGSYLCSCP 1472
Query: 250 PGFRLRADRVSC 261
F L V C
Sbjct: 1473 QDFELNPSGVGC 1484
Score = 95.9 bits (237), Expect = 2e-19
Identities = 70/221 (31%), Positives = 97/221 (43%), Gaps = 24/221 (10%)
Query: 87 SCQDGEQGATCPETHGPCGEYG-CDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDE 145
+C D ++ C GPCG +G C T C+ C GF++ + G C D++E
Sbjct: 2482 ACFDNDE---CSAQPGPCGAHGHCHNTPGSFRCE-----CHQGFTLVSSGHG--CEDVNE 2531
Query: 146 CV-TSSCEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDECLGTP--C-QQRCKNSIGSY 201
C C+ C N GG+ C C G + C D +EC +P C C+N++G +
Sbjct: 2532 CDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGF 2591
Query: 202 KCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTCRPGFRLRADRVSC 261
+C C +GF C +V+EC R C +SC NT G FLC C G+ RA + C
Sbjct: 2592 RCVCPSGFDFDQALGGCQEVDECAG--RRGPCSYSCANTPGGFLCGCPQGY-FRAGQGHC 2648
Query: 262 EAFPKAVLAPSAILQPRQHPSKMLLLLPEAGRPALSPGHSP 302
V P+ P K LL EA G SP
Sbjct: 2649 ------VSGLGFSPGPQDTPDKEELLSSEACYECKINGLSP 2683
Score = 92.8 bits (229), Expect = 1e-18
Identities = 79/263 (30%), Positives = 100/263 (38%), Gaps = 48/263 (18%)
Query: 44 VCLSGFGSGCC---PGWAPSMGG-----------------GHCTLPLCSFGC-------- 75
VCL+ GS C PG+ + GG GHCT SF C
Sbjct: 545 VCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAV 604
Query: 76 --GSGICIAPNVCSCQDG--EQGATCPETHGPCGEYGCDLTCNHGGCQEVARVCPVGFS- 130
+C+ +V S G E+G+ G + C G E ++CP S
Sbjct: 605 GTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSA 664
Query: 131 ----MTETAVGIRCT--DIDECVTSS---CEGHCVNTEGGFVCECGPGMQLSADRHSCQD 181
+ + +GI DI+EC G C N G + C C G + A C D
Sbjct: 665 EFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTD 724
Query: 182 TDECL--GTPCQQR-CKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCH 238
DEC C C+NS GSY CSC GFH + C DV+EC L C
Sbjct: 725 VDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDEC---LSSPCVSGVCR 781
Query: 239 NTVGSFLCTCRPGFRLRADRVSC 261
N GS+ C C PG RL C
Sbjct: 782 NLAGSYTCKCGPGSRLDPSGTFC 804
Score = 89.7 bits (221), Expect = 1e-17
Identities = 82/258 (31%), Positives = 111/258 (43%), Gaps = 56/258 (21%)
Query: 55 PGWAPSMGGGHCTLPLCSFGC---------GSG-ICIAPNVCSC----QDGEQGATCPET 100
PG P+ G C SF C SG +C+ + C + E G T P
Sbjct: 877 PGVCPN---GRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLP-- 931
Query: 101 HGPCGEYGCDLTCNHGG------CQ--------EVARVCP--VGFSMTETAVGIRC-TDI 143
G+Y D+ C G C+ E A +CP +GF+ + G D+
Sbjct: 932 ----GKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDV 987
Query: 144 DECVTSS---CEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDECLGTP--CQQ-RCKNS 197
+EC G C NT G F C C G L A +C D DEC +P C Q C N+
Sbjct: 988 NECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNT 1047
Query: 198 IGSYKCSC----RTGFHLHGNRHSCVDVNECRRPLERRVCHH-SCHNTVGSFLCTCRPGF 252
GS++C C +GF L N C+DV+EC R + +C +C NT GS+ C C PG
Sbjct: 1048 PGSFECECFPGYESGFMLMKN---CMDVDECAR--DPLLCRGGTCTNTDGSYKCQCPPGH 1102
Query: 253 RLRADRVSCEAFPKAVLA 270
L A +CE + L+
Sbjct: 1103 ELTAKGTACEDIDECSLS 1120
Score = 84.0 bits (206), Expect = 6e-16
Identities = 80/281 (28%), Positives = 108/281 (38%), Gaps = 54/281 (19%)
Query: 53 CCPGWAPSMGGGHCT-LPLCS--FGCGSGICI---APNVCSC-QDGE---QGATCPETH- 101
C G+ GGG+CT + C+ C +G+CI +CSC QD E G C +T
Sbjct: 1430 CNGGYELDRGGGNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRA 1489
Query: 102 GPC---------------GEYGCDLT------------------CNHGGCQEVARVCPVG 128
G C E G +T C E +CP G
Sbjct: 1490 GNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGG 1549
Query: 129 FSMTETAVGIRCTDIDEC--VTSSCEG-HCVNTEGGFVCECGPGMQLSADRHSCQDTDEC 185
+ + DIDEC + C+G CVNT G F CEC PG LS C+D DEC
Sbjct: 1550 EGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDEC 1609
Query: 186 ---LGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNE--CRRPLERRVCHHSCHNT 240
G C N++G+Y C C + ++C+D+ + C R C +
Sbjct: 1610 STHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHY-NGTCQNELAFN 1668
Query: 241 VGSFLCTCRPGFRLRADRVSCEAFPKAVLAPSAILQPRQHP 281
V +C C +R CEA P + IL Q P
Sbjct: 1669 VTRKMCCCSYNIGQAWNR-PCEACPTPISPDYQILCGNQAP 1708
Score = 81.6 bits (200), Expect = 3e-15
Identities = 44/116 (37%), Positives = 59/116 (50%), Gaps = 10/116 (8%)
Query: 113 CNHGGCQEVAR----VCPVGFSMTETAVGIRCTDIDECVTSS--CE-GHCVNTEGGFVCE 165
C +G C+ + VC +G+ A G CTD+DEC +S C+ G C N+ G + C
Sbjct: 693 CANGVCENLRGSYRCVCNLGYEAG--ASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCS 750
Query: 166 CGPGMQLSADRHSCQDTDECLGTPCQQR-CKNSIGSYKCSCRTGFHLHGNRHSCVD 220
C PG D C+D DECL +PC C+N GSY C C G L + C+D
Sbjct: 751 CPPGFHFWQDTEICKDVDECLSSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLD 806
Score = 75.5 bits (184), Expect = 2e-13
Identities = 72/264 (27%), Positives = 102/264 (38%), Gaps = 53/264 (20%)
Query: 46 LSGFGSGCCPGWAPSM-----GGGHCTLP--LCSFGC----GSGICIAPNVCSCQDGEQG 94
+ GF C G+ P + C+L LC+F C GS +C P + + E G
Sbjct: 2145 IGGFECACADGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLR--EDG 2202
Query: 95 ATCPETHGPCGEYGCDLTCNHGGCQEV----ARVCPVGFSMTETAVGIRCTDIDECVTSS 150
A C + C + D C+ + A VCP G + G CTD +EC
Sbjct: 2203 AMCRDVD-ECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGS-GEGCTDDNECHAQP 2260
Query: 151 ---CEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDE--CLGTPCQQRCKN------SIG 199
G CVNT G F C+C G Q S C D + C Q C++ ++
Sbjct: 2261 DLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVT 2320
Query: 200 SYKCSCRTG--------------------FHLHGNRHSCV--DVNECRRPLERRVCHHSC 237
+C C G HG+ ++ DV+ECR L H C
Sbjct: 2321 RAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRM-LAHLCAHGEC 2379
Query: 238 HNTVGSFLCTCRPGFRLRADRVSC 261
N++GSF C C+ G+ A +C
Sbjct: 2380 INSLGSFRCHCQAGYTPDATATTC 2403
Score = 73.9 bits (180), Expect = 6e-13
Identities = 83/308 (26%), Positives = 115/308 (37%), Gaps = 67/308 (21%)
Query: 7 LRAACVALLLPGAPARGYTGRKP--------PGHFAAERRRLGPHVCLSGFGSGCCPGWA 58
+R+ C + G+ AR + G P H E +L P + F + C G
Sbjct: 616 VRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLG 675
Query: 59 PSMGG---GHCTLPLCSFGCGSGICI---APNVCSCQDGEQGATCPETHGPCGEYGCD-L 111
+ G C L C +G+C C C G + + E + L
Sbjct: 676 ITTDGRDINECALD--PEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECALNSL 733
Query: 112 TCNHGGCQE----VARVCPVGFSM-TETAVGIRCTDIDECVTSSC-EGHCVNTEGGFVCE 165
C++G CQ + CP GF +T + C D+DEC++S C G C N G + C+
Sbjct: 734 LCDNGWCQNSPGSYSCSCPPGFHFWQDTEI---CKDVDECLSSPCVSGVCRNLAGSYTCK 790
Query: 166 CGPGMQLSADRHSCQDT------------------------DECL-------GTPCQQRC 194
CGPG +L C D+ EC G+PC +RC
Sbjct: 791 CGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPC-ERC 849
Query: 195 KNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHS-CHNTVGSFLCTCRPGFR 253
+ +C GF +C DVNEC VC + C NT GSF C C G
Sbjct: 850 E-----IDPACARGF-ARMTGVTCDDVNECES--FPGVCPNGRCVNTAGSFRCECPEGLM 901
Query: 254 LRADRVSC 261
L A C
Sbjct: 902 LDASGRLC 909
Score = 71.2 bits (173), Expect = 4e-12
Identities = 89/305 (29%), Positives = 117/305 (38%), Gaps = 72/305 (23%)
Query: 24 YTGRKPPGHFAAERRRLGPHV--CLSGFGSGCCPGWAPSMGGGHCTLPLCSFGCGSGICI 81
Y+ PPG + + V CLS S C G ++ G + C CG G +
Sbjct: 747 YSCSCPPGFHFWQDTEICKDVDECLS---SPCVSGVCRNLAGSYT----CK--CGPGSRL 797
Query: 82 APNVCSCQDGEQGATC----PETHGPCGEYGCDLT---CNHGG------CQ--EVARVCP 126
P+ C D +G TC E+ G L C G C+ E+ C
Sbjct: 798 DPSGTFCLDSTKG-TCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCERCEIDPACA 856
Query: 127 VGFSMTETAVGIRCTDIDECVT--SSC-EGHCVNTEGGFVCECGPGMQLSADRHSCQDT- 182
GF+ G+ C D++EC + C G CVNT G F CEC G+ L A C D
Sbjct: 857 RGFARM---TGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVR 913
Query: 183 ----------DECLGT-PCQQR---CKNSIGSY------------------KCSCRTGFH 210
DEC T P + R C SIG+ C GF
Sbjct: 914 LEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFA 973
Query: 211 LH---GNRHSCVDVNECRRPLERRVCHH-SCHNTVGSFLCTCRPGFRLRADRVSCEAFPK 266
R DVNEC+ + +C H +C NTVGSF C C GF L A +C +
Sbjct: 974 SRDFLSGRPFYKDVNECK--VFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDE 1031
Query: 267 AVLAP 271
++P
Sbjct: 1032 CRISP 1036
Score = 57.8 bits (138), Expect = 5e-08
Identities = 47/168 (27%), Positives = 60/168 (35%), Gaps = 30/168 (17%)
Query: 41 GPHVCLSGFGSGCCPGWAPSMGGGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGATCPET 100
GPH C G + +GG C+ C G C D + A P T
Sbjct: 2534 GPHRCQHGCQN--------QLGGYRCS-------CPQGFTQHSQWAQCVDENECALSPPT 2578
Query: 101 HGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECV--TSSCEGHCVNT 158
CG C T C VCP GF + G C ++DEC C C NT
Sbjct: 2579 ---CGSASCRNTLGGFRC-----VCPSGFDFDQALGG--CQEVDECAGRRGPCSYSCANT 2628
Query: 159 EGGFVCECGPGMQLSADRHSCQDTDECLG---TPCQQRCKNSIGSYKC 203
GGF+C C G + H G TP ++ +S Y+C
Sbjct: 2629 PGGFLCGCPQGYFRAGQGHCVSGLGFSPGPQDTPDKEELLSSEACYEC 2676
Score = 52.0 bits (123), Expect = 3e-06
Identities = 53/206 (25%), Positives = 75/206 (36%), Gaps = 50/206 (24%)
Query: 97 CPETHGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTE-TAVGIRCTDIDECVTSS--C-E 152
C E G C C T C+ CP G+ ++E T + C DIDEC T S C
Sbjct: 1567 CQELPGLCQGGDCVNTFGSFQCE-----CPPGYHLSEHTRI---CEDIDECSTHSGICGP 1618
Query: 153 GHCVNTEGGFVCECGPGMQLSADRHSCQDTDECL------GTPCQQRCKNSIGSYKCSCR 206
G C NT G + C C ++C D + + GT CQ ++ C C
Sbjct: 1619 GTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGT-CQNELAFNVTRKMCCCS 1677
Query: 207 TGFHLHGNR--HSC----------------------------VDVNECRRPLERRVCHHS 236
NR +C +D++EC + +
Sbjct: 1678 YNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGE-IPAICANGI 1736
Query: 237 CHNTVGSFLCTCRPGFRLRADRVSCE 262
C N +GSF C C GF + ++CE
Sbjct: 1737 CINQIGSFRCECPAGFNYNSILLACE 1762
Score = 35.0 bits (79), Expect = 0.33
Identities = 57/220 (25%), Positives = 79/220 (35%), Gaps = 56/220 (25%)
Query: 402 PGCSQCWCEDGKVTCEKVRCEAA--CSHPIPSRDGGCCPSCTGCFHSGVVRAEGDVFSPP 459
PG +C C G + CE C+ + D G C + G + R E ++ P
Sbjct: 1342 PGSYRCTCRQG-FAGDGFFCEDRDECAENVDLCDNGQCLNAPGGY-----RCECEMGFDP 1395
Query: 460 NENCTVCV----CLAGNVSCISPECPSGPCQTPPQTDCCTCVPVRCYFHGRWYADGAVFS 515
E+ C C GN+ C G C+ P C C +G + D
Sbjct: 1396 TEDHRACQDVDECAQGNL------CAFGSCENLPGMFRCIC-------NGGYELD----R 1438
Query: 516 GGGD-----ECTTCV-CQNGEVECSFMPCPELACPREEWRLGP----------GQCCFTC 559
GGG+ EC V C NG C P L +++ L P G C
Sbjct: 1439 GGGNCTDINECADPVNCINGV--CINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLET 1496
Query: 560 QEPTPS-TGCSLDDN-GVE-----FPIGQIWSPGDPCELC 592
+ S CS + GV +G+ W G+PCELC
Sbjct: 1497 HDRGDSGISCSAEIGVGVTRASCCCSLGRAW--GNPCELC 1534
Score = 32.0 bits (71), Expect = 2.8
Identities = 79/331 (23%), Positives = 104/331 (31%), Gaps = 93/331 (28%)
Query: 475 CISPECPSGPCQTPPQTDCCTCVPVRCYFHGRWY---ADGAVFSGGGDECTTCVCQNGEV 531
C S C G C P T C C P R D + SGG CV G
Sbjct: 453 CTSSPCHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSF 512
Query: 532 ECSFMPCPELACPREEWRLGP-GQCCFTCQEPTPSTGC----SLDDNGVEFPI---GQIW 583
+C C + L P G+ C E ST C L+++G + G +
Sbjct: 513 QC--------VC-NAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLL 563
Query: 584 SPG-------DPCE---LCI----CQADGSVSCKRTDCVDSCPHPIRIPGQCCPDCSAGC 629
+PG D C+ +C+ +GS C+ C+ + G+ C D
Sbjct: 564 APGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQ---CLGGL--AVGTDGRVCVDTHVRS 618
Query: 630 TYTGRIFYNN--ETFPSVLDPCLSCICLLGSVACSPVDCPITCTYPFHPDGECCPVC--R 685
T G I + FP + C C P H GE C +C +
Sbjct: 619 TCYGAIEKGSCARPFPGTVTKSECC-----------------CANPDHGFGEPCQLCPAK 661
Query: 686 DCNYEGRKVANGQVFT----------LDDEPCT-----------RCTCQLG-EVSCEKVP 723
D ++G T LD E C RC C LG E
Sbjct: 662 DSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKD 721
Query: 724 CQRA--CADPALL---------PGDCCSSCP 743
C CA +LL PG SCP
Sbjct: 722 CTDVDECALNSLLCDNGWCQNSPGSYSCSCP 752
Score = 30.8 bits (68), Expect = 6.3
Identities = 51/206 (24%), Positives = 71/206 (34%), Gaps = 61/206 (29%)
Query: 480 CPSGPCQTPPQTDCCTCVPVRCYFHGRWYADGAVFSGGGD----ECTTCVCQN--GEVEC 533
C +G CQ P + C+C P FH ++ D + + C + VC+N G C
Sbjct: 735 CDNGWCQNSPGSYSCSCPP---GFH--FWQDTEICKDVDECLSSPCVSGVCRNLAGSYTC 789
Query: 534 SFMPCPELACPREEWRLGP-GQCCF-----TCQEPTPSTGCSLDDNGVEF------PIGQ 581
P RL P G C TC + C ++ G +G
Sbjct: 790 KCGPGS---------RLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGA 840
Query: 582 IWSPGDPCELCICQADGSVSCKRTDCVDSCPHPIRIPGQCCPDCSAGCTYTGRIFYNNET 641
W G PCE C + +C R R+ G C D + E+
Sbjct: 841 AW--GSPCERC----EIDPACARGFA--------RMTGVTCDDVN-----------ECES 875
Query: 642 FPSVLDPCLSCICLLGSVACSPVDCP 667
FP V P C+ GS C +CP
Sbjct: 876 FPGVC-PNGRCVNTAGSFRC---ECP 897
>gi|19743803 fibulin 5 precursor [Homo sapiens]
Length = 448
Score = 120 bits (300), Expect = 8e-27
Identities = 61/142 (42%), Positives = 77/142 (54%), Gaps = 12/142 (8%)
Query: 124 VCPVGFSMTETAVGIRCTDIDECVTSSCEGH----CVNTEGGFVCECGPGMQLSADRHSC 179
+C G+ M E+ +C D+DEC T S + + C+NTEGG+ C C G L + C
Sbjct: 112 ICRFGYQMDESN---QCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQ--C 166
Query: 180 QDTDECLGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHN 239
D DEC CQQ C N GSY C+C GF L+ + SC DVNEC C +C N
Sbjct: 167 LDIDECRYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNEC---ATENPCVQTCVN 223
Query: 240 TVGSFLCTCRPGFRLRADRVSC 261
T GSF+C C PG+ L D V C
Sbjct: 224 TYGSFICRCDPGYELEEDGVHC 245
Score = 110 bits (274), Expect = 8e-24
Identities = 82/250 (32%), Positives = 108/250 (43%), Gaps = 39/250 (15%)
Query: 51 SGCCPGWAPSMGGGH---CTLPL-CSFGCG---SGICIAPNVCS-----------CQDGE 92
SG P AP + + + PL C FG S C+ + C+ C + E
Sbjct: 89 SGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDSHQCNPTQICINTE 148
Query: 93 QGATCPETHGPCGEYGCDLT---CNHGGCQEVAR--------VCPVGFSMTETAVGIRCT 141
G TC T G G L C +G CQ++ C GF++ E G C
Sbjct: 149 GGYTCSCTDGYWLLEGQCLDIDECRYGYCQQLCANVPGSYSCTCNPGFTLNED--GRSCQ 206
Query: 142 DIDECVTSS-CEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDECLGTP--CQQRCKNSI 198
D++EC T + C CVNT G F+C C PG +L D C D DEC + CQ C N
Sbjct: 207 DVNECATENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQP 266
Query: 199 GSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLC----TC-RPGFR 253
G+Y CSC G+ L + SC D+NEC +C+N G F C C P R
Sbjct: 267 GTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLR 326
Query: 254 LRADRVSCEA 263
+ +R C A
Sbjct: 327 ISDNRCMCPA 336
Score = 75.5 bits (184), Expect = 2e-13
Identities = 56/189 (29%), Positives = 74/189 (39%), Gaps = 60/189 (31%)
Query: 125 CPVGFSMTETAVGIRCTDIDEC--VTSSCEGH--CVNTEGGFVC---------------- 164
C GF + + +C DIDEC + +C G CVN GG++C
Sbjct: 27 CTNGFDLDRQSG--QCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRGPYSNPY 84
Query: 165 ---------------------------ECGPGMQLSADRHSCQDTDECLGTPCQ----QR 193
C G Q+ + + C D DEC Q Q
Sbjct: 85 STPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMD-ESNQCVDVDECATDSHQCNPTQI 143
Query: 194 CKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTCRPGFR 253
C N+ G Y CSC G+ L + C+D++ECR C C N GS+ CTC PGF
Sbjct: 144 CINTEGGYTCSCTDGYWLLEGQ--CLDIDECR----YGYCQQLCANVPGSYSCTCNPGFT 197
Query: 254 LRADRVSCE 262
L D SC+
Sbjct: 198 LNEDGRSCQ 206
Score = 41.2 bits (95), Expect = 0.005
Identities = 34/147 (23%), Positives = 46/147 (31%), Gaps = 48/147 (32%)
Query: 155 CVNTEGGFVCECGPGMQLSADRHSCQDTDECLGTP--CQ--QRCKNSIGSYKC------- 203
C+ + G +C G L C D DEC P C+ C N G Y C
Sbjct: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
Query: 204 ------------------------------------SCRTGFHLHGNRHSCVDVNECRRP 227
CR G+ + + CVDV+EC
Sbjct: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQM-DESNQCVDVDECATD 134
Query: 228 LERRVCHHSCHNTVGSFLCTCRPGFRL 254
+ C NT G + C+C G+ L
Sbjct: 135 SHQCNPTQICINTEGGYTCSCTDGYWL 161
>gi|4557733 latent transforming growth factor beta binding protein 2
[Homo sapiens]
Length = 1821
Score = 118 bits (295), Expect = 3e-26
Identities = 101/311 (32%), Positives = 125/311 (40%), Gaps = 40/311 (12%)
Query: 44 VCLSGFGSGCCP----GWAPSMGGGHCT-LPLCS---FGCGSGIC---IAPNVCSCQDGE 92
VC + GS C G+ PS G C + C C G C + C C G
Sbjct: 1107 VCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGF 1166
Query: 93 Q---GATCPETHGPCGEYGCDLTCNHGGCQEVAR----VCPVGFSMTETAVGIRCTDIDE 145
Q G C + + GE C HG C +C GF E G C D+DE
Sbjct: 1167 QLANGTVCEDVNECMGEEHC---APHGECLNSHGSFFCLCAPGFVSAEG--GTSCQDVDE 1221
Query: 146 CVTSS--CEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDEC--LGTPC--QQRCKNSIG 199
C T+ GHCVNTEG F C C G Q S + C D DEC G P +C+NS G
Sbjct: 1222 CATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPG 1281
Query: 200 SYKC--SCRTGFHLHGNRHSCVDVNECRRPLERRVC--HHSCHNTVGSFLCTCRPGFRLR 255
SY+C C+ GFH+ N C+D++EC +C H C NT GSF C C GF +
Sbjct: 1282 SYRCVLGCQPGFHMAPN-GDCIDIDECAND---TMCGSHGFCDNTDGSFRCLCDQGFEIS 1337
Query: 256 ADRVSCEAFPKAVL---APSAILQPRQHPSKMLLLLPEAGRPALSPGHSPPSGAPGPPAG 312
C + L A L S + L + GH P GA G
Sbjct: 1338 PSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMS 1397
Query: 313 VRTTRLPSPTP 323
T +P P
Sbjct: 1398 EAPTGDHAPAP 1408
Score = 95.1 bits (235), Expect = 3e-19
Identities = 83/283 (29%), Positives = 115/283 (40%), Gaps = 66/283 (23%)
Query: 41 GPHVCLS---GFGSGCCPGWA-----------------PSMGGGHCTLPLCSFGC----G 76
GP C++ G+ C PG+ P G G C + S+ C G
Sbjct: 857 GPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCINRVGSYSCFCYPG 916
Query: 77 SGICIAPNVCSCQD---GEQGATCPETHGPC----GEYGCD-----LTCNHGGCQEVAR- 123
+ + CQD EQ C + G C G Y C+ + G CQ++
Sbjct: 917 YTLATSGATQECQDINECEQPGVC--SGGQCTNTEGSYHCECDQGYIMVRKGHCQDINEC 974
Query: 124 ----VCPVG--------FSMTETAVGIR-----CTDIDECVTSS--CEGHCVNTEGGFVC 164
CP G ++ G R C D++EC+T G C N EG F C
Sbjct: 975 RHPGTCPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNECLTPGVCAHGKCTNLEGSFRC 1034
Query: 165 ECGPGMQLSADRHSCQDTDECLG-TPCQQ-RCKNSIGSYKCS-CRTGFHLHGNRHSCVDV 221
C G ++++D CQD DEC C C N+ GS+ CS C G+ ++ + +C D+
Sbjct: 1035 SCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDL 1094
Query: 222 NECRRPLERRVCHHS-CHNTVGSFLC-TCRPGFRLRADRVSCE 262
+EC P VC C NT GSF C C G+R SCE
Sbjct: 1095 DECAFP---GVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCE 1134
Score = 90.9 bits (224), Expect = 5e-18
Identities = 52/130 (40%), Positives = 65/130 (50%), Gaps = 12/130 (9%)
Query: 132 TETAVGIRCTDIDECV---TSSC-EGHCVNTEGGFVCECGPGMQLSADRHSCQDTDECLG 187
T+ V + ID C T+ C G CVN G+ C C PG QL + C D +ECL
Sbjct: 834 TDVLVTLSTPGIDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLR 893
Query: 188 TPC--QQRCKNSIGSYKCSCRTGFHL--HGNRHSCVDVNECRRPLERRVCH-HSCHNTVG 242
PC + RC N +GSY C C G+ L G C D+NEC +P VC C NT G
Sbjct: 894 DPCKGKGRCINRVGSYSCFCYPGYTLATSGATQECQDINECEQP---GVCSGGQCTNTEG 950
Query: 243 SFLCTCRPGF 252
S+ C C G+
Sbjct: 951 SYHCECDQGY 960
Score = 72.4 bits (176), Expect = 2e-12
Identities = 55/191 (28%), Positives = 72/191 (37%), Gaps = 26/191 (13%)
Query: 82 APNVCSCQDGEQG--------------ATCPETHGPCGEYGCDLTCNHGGCQEVARVCPV 127
AP C G++G A C T G CDL C E + +CP
Sbjct: 1407 APTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACDL-CPSEDSAEFSEICPS 1465
Query: 128 GFSMTE-----TAVGIRCTDIDECVTSS---C-EGHCVNTEGGFVCECGPGMQLSADRHS 178
G T TD DECV C G C+NT G+VC C PG A
Sbjct: 1466 GKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKK 1525
Query: 179 CQDTDECLGTPCQQ-RCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHS- 236
C+D DEC C+ C N+ GS+ C C L ++ C++ L H
Sbjct: 1526 CEDHDECQDLACENGECVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDI 1585
Query: 237 CHNTVGSFLCT 247
C V + +C+
Sbjct: 1586 CWKKVTNDVCS 1596
Score = 58.9 bits (141), Expect = 2e-08
Identities = 135/630 (21%), Positives = 183/630 (29%), Gaps = 145/630 (23%)
Query: 165 ECGPGMQLSADRHSCQDTDECL--GTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVN 222
EC G + H CQD +ECL G C N+ GSY C+CR G L +R CV
Sbjct: 607 ECPQGYKRLNLTH-CQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDK 665
Query: 223 E-------CRRPLERRVCHHSCHNTVGSFLCTC-RPGFRLRADRVSCEAFPKAVLAPSAI 274
C R L C + +C C R G +A CE P
Sbjct: 666 AISMLQGLCYRSLGPGTCTLPLAQRITKQICCCSRVG---KAWGSECEKCPLPGTEAFRE 722
Query: 275 LQPRQH-----PSKMLLLL-----PEAGRPALSPGHSPPSGAPGP--------------P 310
+ P H S + L + E RP G PGP
Sbjct: 723 ICPAGHGYTYASSDIRLSMRKAEEEELARPPREQGQRSSGALPGPAERQPLRVVTDTWLE 782
Query: 311 AGVRTTRLPSPTPRLPTSSPSAPVWLLSTLLATPVP---TASLLGNLRPPSLLQGEVMGT 367
AG + S ++ TS AP W+ P+P A + PS + T
Sbjct: 783 AGTIPDKGDSQAGQVTTSVTHAPAWVTGNATTPPMPEQGIAEIQEEQVTPSTDVLVTLST 842
Query: 368 PSSPRGPESPRLAAGPSPCWHLG-----------AMHESRSRWTEP-------------- 402
P R GP C +L +H S++ T+
Sbjct: 843 PGIDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRC 902
Query: 403 ----GCSQCWCEDGKV--------TCEKVRCEAACSHPIPSRDGGC-------------- 436
G C+C G C+ + C P G C
Sbjct: 903 INRVGSYSCFCYPGYTLATSGATQECQDIN---ECEQPGVCSGGQCTNTEGSYHCECDQG 959
Query: 437 --------CPSCTGCFHSGVVRAEGDVFSPPNENCTVC---------VCLAGNVSCISP- 478
C C H G V SP + C C C+ N C++P
Sbjct: 960 YIMVRKGHCQDINECRHPGTCPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVN-ECLTPG 1018
Query: 479 ECPSGPCQTPPQTDCCTCVPVRCYFHGRWYADGAVFSGGGDECTTCVCQNGEVECSFMPC 538
C G C + C+C C T +C N E + C
Sbjct: 1019 VCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSAC 1078
Query: 539 PE--------LACPREEWRLGPGQC-CFTCQEPTPSTGCSLDDNGVE-FPIGQIWSPGDP 588
AC + PG C C S C D G P+G D
Sbjct: 1079 ENGYWVNEDGTACEDLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDE 1138
Query: 589 CELCICQADGSVSCKRTDCVDS-------CPHPIRIP-GQCCPDCS-----AGCTYTGRI 635
CE D SC +C ++ CP ++ G C D + C G
Sbjct: 1139 CE------DPQSSCLGGECKNTVGSYQCLCPQGFQLANGTVCEDVNECMGEEHCAPHGEC 1192
Query: 636 FYNNETFPSVLDPCLSCICLLGSVACSPVD 665
++ +F + P + G +C VD
Sbjct: 1193 LNSHGSFFCLCAP--GFVSAEGGTSCQDVD 1220
Score = 57.0 bits (136), Expect = 8e-08
Identities = 36/92 (39%), Positives = 43/92 (46%), Gaps = 11/92 (11%)
Query: 10 ACVALLLPGAPARGYTGRKPPGHFAAERRRL-GPHVCLSGFGSGCCPGWAPSMGGGHCTL 68
A AL G P R +G PP R RL G +VC G CCPGW + HC
Sbjct: 138 AAPALPRLGTPQR--SGAAPP---TPPRGRLTGRNVC----GGQCCPGWTTANSTNHCIK 188
Query: 69 PLCSFGC-GSGICIAPNVCSCQDGEQGATCPE 99
P+C C G C P +C C+ G +GA C E
Sbjct: 189 PVCEPPCQNRGSCSRPQLCVCRSGFRGARCEE 220
Score = 56.2 bits (134), Expect = 1e-07
Identities = 31/88 (35%), Positives = 42/88 (47%), Gaps = 8/88 (9%)
Query: 130 SMTETAVGIRCTDIDEC-VTSSCE-GHCVNTEGGFVCECGPGMQLSADRHSCQDTDEC-- 185
S E G +EC + + CE G CV G+ C+C G QL A +C D +EC
Sbjct: 1721 SHPEPPAGFEGLQAEECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDD 1780
Query: 186 LGTPC----QQRCKNSIGSYKCSCRTGF 209
L P C+N+ GSY+C C G+
Sbjct: 1781 LNGPAVLCVHGYCENTEGSYRCHCSPGY 1808
Score = 52.8 bits (125), Expect = 2e-06
Identities = 29/73 (39%), Positives = 32/73 (43%), Gaps = 2/73 (2%)
Query: 193 RCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRV--CHHSCHNTVGSFLCTCRP 250
RC Y C C GF L +CVDVNEC V H C NT GS+ C C P
Sbjct: 1747 RCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRCHCSP 1806
Query: 251 GFRLRADRVSCEA 263
G+ A C A
Sbjct: 1807 GYVAEAGPPHCTA 1819
Score = 43.5 bits (101), Expect = 0.001
Identities = 63/277 (22%), Positives = 85/277 (30%), Gaps = 78/277 (28%)
Query: 49 FGSGCCPGWAPSMGGGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGATCPETHGPCGEYG 108
+G C W G C GC G +APN C D ++ A CG +G
Sbjct: 1266 YGDPVCGTWKCENSPGSYR---CVLGCQPGFHMAPNG-DCIDIDECAN----DTMCGSHG 1317
Query: 109 -CDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDEC--VTSSCEGH-CVNTEGGFVC 164
CD T C +C GF ++ + G C D++EC + + C C N EG F+C
Sbjct: 1318 FCDNTDGSFRC-----LCDQGFEISPS--GWDCVDVNECELMLAVCGAALCENVEGSFLC 1370
Query: 165 --------------ECGP----GMQLS----ADRHSCQDTDECLG-----TPCQQRCKNS 197
C P G +S D +C PC +
Sbjct: 1371 LCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRN 1430
Query: 198 IGSYKCSCRTGFHLHGNRHSC--------------------------------VDVNECR 225
+C C G C D +EC
Sbjct: 1431 TTQAECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECV 1490
Query: 226 RPLERRVCHHSCHNTVGSFLCTCRPGFRLRADRVSCE 262
+ C NTV ++C C PGF A CE
Sbjct: 1491 IFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCE 1527
Score = 40.8 bits (94), Expect = 0.006
Identities = 24/77 (31%), Positives = 31/77 (40%), Gaps = 12/77 (15%)
Query: 113 CNHGGCQEVARV----CPVGFSMTETAVGIRCTDIDEC------VTSSCEGHCVNTEGGF 162
C +G C V C GF + A + C D++EC G+C NTEG +
Sbjct: 1743 CENGRCVRVREGYTCDCFEGFQLD--AAHMACVDVNECDDLNGPAVLCVHGYCENTEGSY 1800
Query: 163 VCECGPGMQLSADRHSC 179
C C PG A C
Sbjct: 1801 RCHCSPGYVAEAGPPHC 1817
Score = 31.2 bits (69), Expect = 4.8
Identities = 54/175 (30%), Positives = 64/175 (36%), Gaps = 40/175 (22%)
Query: 222 NECRRPLERRVCHHSCHNTVGSF----LCTCRPGFR-LRADRVSCEAFPKAVLAP-SAIL 275
N C +P VC C N GS LC CR GFR R + E P P ++ L
Sbjct: 184 NHCIKP----VCEPPCQNR-GSCSRPQLCVCRSGFRGARCE----EVIPDEEFDPQNSRL 234
Query: 276 QPRQ--HPSKMLLLLPEAGRPALS----PGHSPPSGAPGPPAGVRTTRLPSPTPRLPTSS 329
PR+ S L AG L+ P P PPAG + L +
Sbjct: 235 APRRWAERSPNLRRSSAAGEGTLARAQPPAPQSPPAPQSPPAGTLS--------GLSQTH 286
Query: 330 PSAP-VWLLSTLLATPVPTAS--LLGNLRPP--------SLLQGEVMGTPSSPRG 373
PS V L T+ P TAS L N PP Q + PSSP G
Sbjct: 287 PSQQHVGLSRTVRLHPTATASSQLSSNALPPGPGLEQRDGTQQAVPLEHPSSPWG 341
>gi|110347437 latent transforming growth factor beta binding protein
4 isoform c [Homo sapiens]
Length = 1557
Score = 116 bits (290), Expect = 1e-25
Identities = 96/264 (36%), Positives = 111/264 (42%), Gaps = 43/264 (16%)
Query: 17 PGAPARGYTGRKPPGHFAAERRRLGPHVCLSGF-GSGC------CPGWAPSMGGGHCTLP 69
PG RG + PG F VC +GF GS C C P G G C
Sbjct: 612 PGLCGRGAC-KNLPGSFRC--------VCPAGFRGSACEEDVDECAQEPPPCGPGRCDNT 662
Query: 70 LCSFGCG--SGICIAPNVCSCQDGEQGATCPETHGPCGEYGCDLTCNHGGCQEVARVCPV 127
SF C +G CQD ++ A P PC C+ T C VCP+
Sbjct: 663 AGSFHCACPAGFRSRGPGAPCQDVDECARSPP---PCTYGRCENTEGSFQC-----VCPM 714
Query: 128 GFSMTETAVGIRCTDIDECVTS-SCEGH-CVNTEGGFVCE-CGPGMQLSADRHSCQDTDE 184
GF G C D+DEC +C G CVN+ G F C C G L R C D DE
Sbjct: 715 GFQ--PNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGR--CTDVDE 770
Query: 185 CLG--TPC--QQRCKNSIGSYKCSCRTGFHLHGNRHS-CVDVNECRRPLERRVC--HHSC 237
C PC C N+ GS++CSC G+ R C DVNEC LE C H C
Sbjct: 771 CSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNEC---LEGDFCFPHGEC 827
Query: 238 HNTVGSFLCTCRPGFRLRADRVSC 261
NT GSF CTC PG+R SC
Sbjct: 828 LNTDGSFACTCAPGYRPGPRGASC 851
Score = 110 bits (276), Expect = 5e-24
Identities = 82/241 (34%), Positives = 104/241 (43%), Gaps = 26/241 (10%)
Query: 41 GPHVCLSGFGSGCCPGWAPSMGGGHCTLPLCSF--GCGSGICIAPNVCSCQDGEQGATCP 98
GP + SG SG C G G C + C SG ++P C D ++ C
Sbjct: 469 GPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDE---CR 525
Query: 99 ETHGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDEC--VTSSCE-GHC 155
PC C+ + C VC GF A C D+DEC V C+ G C
Sbjct: 526 RVPPPCAPGRCENSPGSFRC-----VCGPGFRAGPRAA--ECLDVDECHRVPPPCDLGRC 578
Query: 156 VNTEGGFVCECGPGMQLSADRHSCQDTDECLGTP--C-QQRCKNSIGSYKCSCRTGFHLH 212
NT G F+C C G Q + SCQD DEC +P C + CKN GS++C C GF
Sbjct: 579 ENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGF--- 635
Query: 213 GNRHSC-VDVNECRRPLERRVCHHS-CHNTVGSFLCTCRPGFRLRADRVSCEAFPKAVLA 270
+C DV+EC + E C C NT GSF C C GFR R C+ + +
Sbjct: 636 -RGSACEEDVDECAQ--EPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARS 692
Query: 271 P 271
P
Sbjct: 693 P 693
Score = 110 bits (275), Expect = 6e-24
Identities = 95/305 (31%), Positives = 112/305 (36%), Gaps = 83/305 (27%)
Query: 29 PPGHFAAERRRLGPHVCLSGFGSGCCPGWAPSMGGGHCTLPLCSFG-CGSGICIAPNV-- 85
PP G +C+ G P A CT S G CG G C N+
Sbjct: 571 PPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQ---SPGLCGRGAC--KNLPG 625
Query: 86 ---CSCQDGEQGATCPETHG-------PCGEYGCDLTCNHGGCQEVARVCPVGFSMTETA 135
C C G +G+ C E PCG CD T C CP GF
Sbjct: 626 SFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHC-----ACPAGFR--SRG 678
Query: 136 VGIRCTDIDECVTSS---CEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDEC---LGTP 189
G C D+DEC S G C NTEG F C C G Q + C+D DEC L P
Sbjct: 679 PGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACP 738
Query: 190 CQQRCKNSIGSYKC-SCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTC 248
Q+ C NS GS++C +C +G HLH R C DV+EC H C NT GSF C+C
Sbjct: 739 GQE-CVNSPGSFQCRTCPSGHHLHRGR--CTDVDECSSGAPPCGPHGHCTNTEGSFRCSC 795
Query: 249 RPGFRLRADRVSCEAFPKAVLAPSAILQPRQHPSKMLLLLPEAGRPALSPGHSPPSGAPG 308
+PG+ PSG PG
Sbjct: 796 ------------------------------------------------APGYRAPSGRPG 807
Query: 309 PPAGV 313
P A V
Sbjct: 808 PCADV 812
Score = 92.0 bits (227), Expect = 2e-18
Identities = 98/329 (29%), Positives = 122/329 (37%), Gaps = 78/329 (23%)
Query: 42 PH-VCLSGFGS---GCCPGWAPSMGGGHCT-LPLCSFG--CGSGICI------------- 81
PH CL+ GS C PG+ P G C + CS C SGIC
Sbjct: 823 PHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPG 882
Query: 82 ---APNVCSCQDGEQGATCPETHGP--CGEYGCDLTCNHGGCQEVARVCPVGFSMTETAV 136
P++ SC D ++ C E GP CG C+ N G R C G+
Sbjct: 883 HRAGPDLASCLDVDE---CRE-RGPALCGSQRCE---NSPGSYRCVRDCDPGYHAGPEGT 935
Query: 137 GIRCTDIDECVTSSCE----GHCVNTEGGFVCE--CGPGMQLSADRHSCQDTDECLGTP- 189
C D+DEC E C NT G + C C PG Q + CQD DEC
Sbjct: 936 ---CDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGG-GCQDVDECRNRSF 991
Query: 190 --CQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHS-CHNTVGSFLC 246
C+N GS++C C G+ + CVDVNEC + VC + C N GSFLC
Sbjct: 992 CGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECE--TLQGVCGAALCENVEGSFLC 1049
Query: 247 TCRPGFRLRADRVSCEAFPKAVLAPSAILQPRQHPSKMLLLLPEAGRPALSPGHSPPSGA 306
C P D ++ P P S G P S
Sbjct: 1050 VC-PNSPEEFDPMTGRCVP----------------------------PRTSAGTFPGSQP 1080
Query: 307 PGPPAGVRTTR-LPSPTPRLPTSSPSAPV 334
P + V R P P PR P++ PV
Sbjct: 1081 QAPASPVLPARPPPPPLPRRPSTPRQGPV 1109
Score = 91.3 bits (225), Expect = 4e-18
Identities = 76/268 (28%), Positives = 102/268 (38%), Gaps = 50/268 (18%)
Query: 17 PGAPARGY---TGRKPPGHFAAERRRLGPHVCLSGFGSGCCPGWAPSMGGGHCT-LPLCS 72
PGAP + PP + G C+ C G+ P+ G C + C
Sbjct: 679 PGAPCQDVDECARSPPPCTYGRCENTEGSFQCV------CPMGFQPNTAGSECEDVDECE 732
Query: 73 --FGCGSGICI-APNVCSCQDGEQGATCPETHG-----------------PCGEYG-CDL 111
C C+ +P C+ TCP H PCG +G C
Sbjct: 733 NHLACPGQECVNSPGSFQCR------TCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTN 786
Query: 112 TCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECVTSSC---EGHCVNTEGGFVCECGP 168
T C C G+ G C D++EC+ G C+NT+G F C C P
Sbjct: 787 TEGSFRCS-----CAPGYRAPSGRPG-PCADVNECLEGDFCFPHGECLNTDGSFACTCAP 840
Query: 169 GMQLSADRHSCQDTDECLGTP-CQQR-CKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRR 226
G + SC D DEC CQ C N+ GS++C C G + SC+DV+ECR
Sbjct: 841 GYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRE 900
Query: 227 PLERRVCHHSCHNTVGSFLCT--CRPGF 252
C N+ GS+ C C PG+
Sbjct: 901 RGPALCGSQRCENSPGSYRCVRDCDPGY 928
Score = 72.4 bits (176), Expect = 2e-12
Identities = 143/623 (22%), Positives = 198/623 (31%), Gaps = 148/623 (23%)
Query: 56 GWAPSMGGGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGATCPETHGPCGEYGCDLTCNH 115
G++ + G G+C L C S + P + + Q C G + C L
Sbjct: 212 GYSDASGFGYCFRELRGGECASPL---PGLRT-----QEVCCRGAGLAWGVHDCQLCSER 263
Query: 116 GGCQEVARV----CPVGFSMTETAVGIRCTDIDECVTSS-CE-GHCVNTEGGFVCECGPG 169
G E CP GF + C D+DEC T C+ G C NT GG+ C C G
Sbjct: 264 LGNSERVSAPDGPCPTGFERVNGS----CEDVDECATGGRCQHGECANTRGGYTCVCPDG 319
Query: 170 MQLSADRHSCQDTDECLGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLE 229
L + R SC + + + + C + CS R +
Sbjct: 320 FLLDSSRSSC--ISQHVISEAKGPCFRVLRDGGCSL-----------------PILRNIT 360
Query: 230 RRVCHHSCHNTVGSFL---CTCRPGFRLRADRVSCEAFPKAVLAPSAI---LQP-RQHPS 282
+++C C + VG C P F R C A P + S + +P Q P
Sbjct: 361 KQIC---CCSRVGKAWGRGCQLCPPFGSEGFREICPAGPGYHYSASDLRYNTRPLGQEPP 417
Query: 283 KMLL----LLPEAGRPALS--PGHS-PPSGAPGPPAGVRTTRLPSPTPRLPTSSPSAPVW 335
++ L LP RP+ P H P P P P P P LP PS P W
Sbjct: 418 RVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPD--------PRPGPELPL--PSIPAW 467
Query: 336 LLSTLLATPVPTASLLGNLRPPSLLQGEVMGTPSSPRGPESPRLAAGPSPCWHLGAMHES 395
+P + PSS +P++ GP C
Sbjct: 468 -----TGPEIPESG------------------PSSGMCQRNPQV-CGPGRC--------- 494
Query: 396 RSRWTEPGCSQCWCEDG-KVTCEKVRC--EAACSHPIPSRDGGCCPSCTGCFHSGVVRAE 452
+ P C C+ G +++ + RC C P G C + G F V
Sbjct: 495 ---ISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFR--CVCGP 549
Query: 453 GDVFSPPNENCTVCVCLAGNVSCISPECPSGPCQTPPQTDCCTCVPVRCYFHGRWYADGA 512
G P C + P C G C+ P + C C G A
Sbjct: 550 GFRAGPRAAECLD----VDECHRVPPPCDLGRCENTPGSFLCVCPA------GYQAAPHG 599
Query: 513 VFSGGGDECTTCVCQNGEVECSFMP------CPE-----------LACPREEWRLGPGQC 555
DECT G C +P CP C +E GPG+C
Sbjct: 600 ASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRC 659
Query: 556 -----CFTCQEPT------PSTGCSLDDNGVEFPIGQIWSPGDPCE---LCICQADGSVS 601
F C P P C D P + + E C+C +
Sbjct: 660 DNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPN 719
Query: 602 CKRTDC--VDSCPHPIRIPGQCC 622
++C VD C + + PGQ C
Sbjct: 720 TAGSECEDVDECENHLACPGQEC 742
Score = 67.0 bits (162), Expect = 8e-11
Identities = 62/200 (31%), Positives = 76/200 (38%), Gaps = 19/200 (9%)
Query: 142 DIDECVT---SSCE-GHCVNTEGGFVCECGPGMQLSADRHSCQDTDECLG--TPCQ-QRC 194
D+DEC C+ G CVNT G+ C C G R C D DEC C+ RC
Sbjct: 1186 DVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRC 1245
Query: 195 KNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTCRPGFRL 254
N++GSY C+C L G++ CV NE + L+ + C VG+ L P
Sbjct: 1246 VNTVGSYHCTCEPPLVLDGSQRRCVS-NE-SQSLDDNL--GVCWQEVGADLVCSHPRLDR 1301
Query: 255 RADRVSCEAFPKAVLAPSAILQPRQHPSKMLLLLPEAGRPALSPGHSPPSGAP---GPPA 311
+A C L P Q L PA SP G P GP
Sbjct: 1302 QATYTECCCLYGEAWGMDCALCPAQDSDDFEALCNVLRPPAYSPPRPGGFGLPYEYGPDL 1361
Query: 312 GVRTTRLP-----SPTPRLP 326
G LP P P LP
Sbjct: 1362 GPPYQGLPYGPELYPPPALP 1381
Score = 54.7 bits (130), Expect = 4e-07
Identities = 30/85 (35%), Positives = 40/85 (47%), Gaps = 8/85 (9%)
Query: 142 DIDEC-VTSSC-EGHCVNTEGGFVCECGPGMQLSADRHSCQDTDEC----LGTP--CQQR 193
+ +EC + C G CV GF C C G +L R +C D +EC +P R
Sbjct: 1466 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1525
Query: 194 CKNSIGSYKCSCRTGFHLHGNRHSC 218
C N+ GS++C CR GF H C
Sbjct: 1526 CLNTDGSFRCICRPGFAPTHQPHHC 1550
Score = 51.6 bits (122), Expect = 3e-06
Identities = 26/62 (41%), Positives = 33/62 (53%), Gaps = 2/62 (3%)
Query: 193 RCKNSIGSYKCSCRTGFHLHGNRHSCVDVNEC-RRPLERRVCHHS-CHNTVGSFLCTCRP 250
RC + C C G+ L R +CVD+NEC +C ++ C NT GSF C CRP
Sbjct: 1480 RCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRP 1539
Query: 251 GF 252
GF
Sbjct: 1540 GF 1541
Score = 38.5 bits (88), Expect = 0.030
Identities = 23/77 (29%), Positives = 32/77 (41%), Gaps = 12/77 (15%)
Query: 113 CNHGGCQEVARV----CPVGFSMTETAVGIRCTDIDECVTSSC------EGHCVNTEGGF 162
C +G C V C G+ + T + C DI+EC + C+NT+G F
Sbjct: 1476 CTNGRCVRVPEGFTCRCFDGYRLDMTRMA--CVDINECDEAEAASPLCVNARCLNTDGSF 1533
Query: 163 VCECGPGMQLSADRHSC 179
C C PG + H C
Sbjct: 1534 RCICRPGFAPTHQPHHC 1550
>gi|110347412 latent transforming growth factor beta binding protein
4 isoform b [Homo sapiens]
Length = 1587
Score = 116 bits (290), Expect = 1e-25
Identities = 96/264 (36%), Positives = 111/264 (42%), Gaps = 43/264 (16%)
Query: 17 PGAPARGYTGRKPPGHFAAERRRLGPHVCLSGF-GSGC------CPGWAPSMGGGHCTLP 69
PG RG + PG F VC +GF GS C C P G G C
Sbjct: 642 PGLCGRGAC-KNLPGSFRC--------VCPAGFRGSACEEDVDECAQEPPPCGPGRCDNT 692
Query: 70 LCSFGCG--SGICIAPNVCSCQDGEQGATCPETHGPCGEYGCDLTCNHGGCQEVARVCPV 127
SF C +G CQD ++ A P PC C+ T C VCP+
Sbjct: 693 AGSFHCACPAGFRSRGPGAPCQDVDECARSPP---PCTYGRCENTEGSFQC-----VCPM 744
Query: 128 GFSMTETAVGIRCTDIDECVTS-SCEGH-CVNTEGGFVCE-CGPGMQLSADRHSCQDTDE 184
GF G C D+DEC +C G CVN+ G F C C G L R C D DE
Sbjct: 745 GFQ--PNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGR--CTDVDE 800
Query: 185 CLG--TPC--QQRCKNSIGSYKCSCRTGFHLHGNRHS-CVDVNECRRPLERRVC--HHSC 237
C PC C N+ GS++CSC G+ R C DVNEC LE C H C
Sbjct: 801 CSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNEC---LEGDFCFPHGEC 857
Query: 238 HNTVGSFLCTCRPGFRLRADRVSC 261
NT GSF CTC PG+R SC
Sbjct: 858 LNTDGSFACTCAPGYRPGPRGASC 881
Score = 110 bits (276), Expect = 5e-24
Identities = 82/241 (34%), Positives = 104/241 (43%), Gaps = 26/241 (10%)
Query: 41 GPHVCLSGFGSGCCPGWAPSMGGGHCTLPLCSF--GCGSGICIAPNVCSCQDGEQGATCP 98
GP + SG SG C G G C + C SG ++P C D ++ C
Sbjct: 499 GPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDE---CR 555
Query: 99 ETHGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDEC--VTSSCE-GHC 155
PC C+ + C VC GF A C D+DEC V C+ G C
Sbjct: 556 RVPPPCAPGRCENSPGSFRC-----VCGPGFRAGPRAA--ECLDVDECHRVPPPCDLGRC 608
Query: 156 VNTEGGFVCECGPGMQLSADRHSCQDTDECLGTP--C-QQRCKNSIGSYKCSCRTGFHLH 212
NT G F+C C G Q + SCQD DEC +P C + CKN GS++C C GF
Sbjct: 609 ENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGF--- 665
Query: 213 GNRHSC-VDVNECRRPLERRVCHHS-CHNTVGSFLCTCRPGFRLRADRVSCEAFPKAVLA 270
+C DV+EC + E C C NT GSF C C GFR R C+ + +
Sbjct: 666 -RGSACEEDVDECAQ--EPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARS 722
Query: 271 P 271
P
Sbjct: 723 P 723
Score = 110 bits (275), Expect = 6e-24
Identities = 95/305 (31%), Positives = 112/305 (36%), Gaps = 83/305 (27%)
Query: 29 PPGHFAAERRRLGPHVCLSGFGSGCCPGWAPSMGGGHCTLPLCSFG-CGSGICIAPNV-- 85
PP G +C+ G P A CT S G CG G C N+
Sbjct: 601 PPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQ---SPGLCGRGAC--KNLPG 655
Query: 86 ---CSCQDGEQGATCPETHG-------PCGEYGCDLTCNHGGCQEVARVCPVGFSMTETA 135
C C G +G+ C E PCG CD T C CP GF
Sbjct: 656 SFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHC-----ACPAGFR--SRG 708
Query: 136 VGIRCTDIDECVTSS---CEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDEC---LGTP 189
G C D+DEC S G C NTEG F C C G Q + C+D DEC L P
Sbjct: 709 PGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACP 768
Query: 190 CQQRCKNSIGSYKC-SCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTC 248
Q+ C NS GS++C +C +G HLH R C DV+EC H C NT GSF C+C
Sbjct: 769 GQE-CVNSPGSFQCRTCPSGHHLHRGR--CTDVDECSSGAPPCGPHGHCTNTEGSFRCSC 825
Query: 249 RPGFRLRADRVSCEAFPKAVLAPSAILQPRQHPSKMLLLLPEAGRPALSPGHSPPSGAPG 308
+PG+ PSG PG
Sbjct: 826 ------------------------------------------------APGYRAPSGRPG 837
Query: 309 PPAGV 313
P A V
Sbjct: 838 PCADV 842
Score = 92.0 bits (227), Expect = 2e-18
Identities = 98/329 (29%), Positives = 122/329 (37%), Gaps = 78/329 (23%)
Query: 42 PH-VCLSGFGS---GCCPGWAPSMGGGHCT-LPLCSFG--CGSGICI------------- 81
PH CL+ GS C PG+ P G C + CS C SGIC
Sbjct: 853 PHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPG 912
Query: 82 ---APNVCSCQDGEQGATCPETHGP--CGEYGCDLTCNHGGCQEVARVCPVGFSMTETAV 136
P++ SC D ++ C E GP CG C+ N G R C G+
Sbjct: 913 HRAGPDLASCLDVDE---CRE-RGPALCGSQRCE---NSPGSYRCVRDCDPGYHAGPEGT 965
Query: 137 GIRCTDIDECVTSSCE----GHCVNTEGGFVCE--CGPGMQLSADRHSCQDTDECLGTP- 189
C D+DEC E C NT G + C C PG Q + CQD DEC
Sbjct: 966 ---CDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGG-GCQDVDECRNRSF 1021
Query: 190 --CQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHS-CHNTVGSFLC 246
C+N GS++C C G+ + CVDVNEC + VC + C N GSFLC
Sbjct: 1022 CGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECE--TLQGVCGAALCENVEGSFLC 1079
Query: 247 TCRPGFRLRADRVSCEAFPKAVLAPSAILQPRQHPSKMLLLLPEAGRPALSPGHSPPSGA 306
C P D ++ P P S G P S
Sbjct: 1080 VC-PNSPEEFDPMTGRCVP----------------------------PRTSAGTFPGSQP 1110
Query: 307 PGPPAGVRTTR-LPSPTPRLPTSSPSAPV 334
P + V R P P PR P++ PV
Sbjct: 1111 QAPASPVLPARPPPPPLPRRPSTPRQGPV 1139
Score = 91.3 bits (225), Expect = 4e-18
Identities = 76/268 (28%), Positives = 102/268 (38%), Gaps = 50/268 (18%)
Query: 17 PGAPARGY---TGRKPPGHFAAERRRLGPHVCLSGFGSGCCPGWAPSMGGGHCT-LPLCS 72
PGAP + PP + G C+ C G+ P+ G C + C
Sbjct: 709 PGAPCQDVDECARSPPPCTYGRCENTEGSFQCV------CPMGFQPNTAGSECEDVDECE 762
Query: 73 --FGCGSGICI-APNVCSCQDGEQGATCPETHG-----------------PCGEYG-CDL 111
C C+ +P C+ TCP H PCG +G C
Sbjct: 763 NHLACPGQECVNSPGSFQCR------TCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTN 816
Query: 112 TCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECVTSSC---EGHCVNTEGGFVCECGP 168
T C C G+ G C D++EC+ G C+NT+G F C C P
Sbjct: 817 TEGSFRCS-----CAPGYRAPSGRPG-PCADVNECLEGDFCFPHGECLNTDGSFACTCAP 870
Query: 169 GMQLSADRHSCQDTDECLGTP-CQQR-CKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRR 226
G + SC D DEC CQ C N+ GS++C C G + SC+DV+ECR
Sbjct: 871 GYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRE 930
Query: 227 PLERRVCHHSCHNTVGSFLCT--CRPGF 252
C N+ GS+ C C PG+
Sbjct: 931 RGPALCGSQRCENSPGSYRCVRDCDPGY 958
Score = 72.4 bits (176), Expect = 2e-12
Identities = 143/623 (22%), Positives = 198/623 (31%), Gaps = 148/623 (23%)
Query: 56 GWAPSMGGGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGATCPETHGPCGEYGCDLTCNH 115
G++ + G G+C L C S + P + + Q C G + C L
Sbjct: 242 GYSDASGFGYCFRELRGGECASPL---PGLRT-----QEVCCRGAGLAWGVHDCQLCSER 293
Query: 116 GGCQEVARV----CPVGFSMTETAVGIRCTDIDECVTSS-CE-GHCVNTEGGFVCECGPG 169
G E CP GF + C D+DEC T C+ G C NT GG+ C C G
Sbjct: 294 LGNSERVSAPDGPCPTGFERVNGS----CEDVDECATGGRCQHGECANTRGGYTCVCPDG 349
Query: 170 MQLSADRHSCQDTDECLGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLE 229
L + R SC + + + + C + CS R +
Sbjct: 350 FLLDSSRSSC--ISQHVISEAKGPCFRVLRDGGCSL-----------------PILRNIT 390
Query: 230 RRVCHHSCHNTVGSFL---CTCRPGFRLRADRVSCEAFPKAVLAPSAI---LQP-RQHPS 282
+++C C + VG C P F R C A P + S + +P Q P
Sbjct: 391 KQIC---CCSRVGKAWGRGCQLCPPFGSEGFREICPAGPGYHYSASDLRYNTRPLGQEPP 447
Query: 283 KMLL----LLPEAGRPALS--PGHS-PPSGAPGPPAGVRTTRLPSPTPRLPTSSPSAPVW 335
++ L LP RP+ P H P P P P P P LP PS P W
Sbjct: 448 RVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPD--------PRPGPELPL--PSIPAW 497
Query: 336 LLSTLLATPVPTASLLGNLRPPSLLQGEVMGTPSSPRGPESPRLAAGPSPCWHLGAMHES 395
+P + PSS +P++ GP C
Sbjct: 498 -----TGPEIPESG------------------PSSGMCQRNPQV-CGPGRC--------- 524
Query: 396 RSRWTEPGCSQCWCEDG-KVTCEKVRC--EAACSHPIPSRDGGCCPSCTGCFHSGVVRAE 452
+ P C C+ G +++ + RC C P G C + G F V
Sbjct: 525 ---ISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFR--CVCGP 579
Query: 453 GDVFSPPNENCTVCVCLAGNVSCISPECPSGPCQTPPQTDCCTCVPVRCYFHGRWYADGA 512
G P C + P C G C+ P + C C G A
Sbjct: 580 GFRAGPRAAECLD----VDECHRVPPPCDLGRCENTPGSFLCVCPA------GYQAAPHG 629
Query: 513 VFSGGGDECTTCVCQNGEVECSFMP------CPE-----------LACPREEWRLGPGQC 555
DECT G C +P CP C +E GPG+C
Sbjct: 630 ASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRC 689
Query: 556 -----CFTCQEPT------PSTGCSLDDNGVEFPIGQIWSPGDPCE---LCICQADGSVS 601
F C P P C D P + + E C+C +
Sbjct: 690 DNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPN 749
Query: 602 CKRTDC--VDSCPHPIRIPGQCC 622
++C VD C + + PGQ C
Sbjct: 750 TAGSECEDVDECENHLACPGQEC 772
Score = 67.0 bits (162), Expect = 8e-11
Identities = 62/200 (31%), Positives = 76/200 (38%), Gaps = 19/200 (9%)
Query: 142 DIDECVT---SSCE-GHCVNTEGGFVCECGPGMQLSADRHSCQDTDECLG--TPCQ-QRC 194
D+DEC C+ G CVNT G+ C C G R C D DEC C+ RC
Sbjct: 1216 DVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRC 1275
Query: 195 KNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTCRPGFRL 254
N++GSY C+C L G++ CV NE + L+ + C VG+ L P
Sbjct: 1276 VNTVGSYHCTCEPPLVLDGSQRRCVS-NE-SQSLDDNL--GVCWQEVGADLVCSHPRLDR 1331
Query: 255 RADRVSCEAFPKAVLAPSAILQPRQHPSKMLLLLPEAGRPALSPGHSPPSGAP---GPPA 311
+A C L P Q L PA SP G P GP
Sbjct: 1332 QATYTECCCLYGEAWGMDCALCPAQDSDDFEALCNVLRPPAYSPPRPGGFGLPYEYGPDL 1391
Query: 312 GVRTTRLP-----SPTPRLP 326
G LP P P LP
Sbjct: 1392 GPPYQGLPYGPELYPPPALP 1411
Score = 54.7 bits (130), Expect = 4e-07
Identities = 30/85 (35%), Positives = 40/85 (47%), Gaps = 8/85 (9%)
Query: 142 DIDEC-VTSSC-EGHCVNTEGGFVCECGPGMQLSADRHSCQDTDEC----LGTP--CQQR 193
+ +EC + C G CV GF C C G +L R +C D +EC +P R
Sbjct: 1496 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1555
Query: 194 CKNSIGSYKCSCRTGFHLHGNRHSC 218
C N+ GS++C CR GF H C
Sbjct: 1556 CLNTDGSFRCICRPGFAPTHQPHHC 1580
Score = 51.6 bits (122), Expect = 3e-06
Identities = 26/62 (41%), Positives = 33/62 (53%), Gaps = 2/62 (3%)
Query: 193 RCKNSIGSYKCSCRTGFHLHGNRHSCVDVNEC-RRPLERRVCHHS-CHNTVGSFLCTCRP 250
RC + C C G+ L R +CVD+NEC +C ++ C NT GSF C CRP
Sbjct: 1510 RCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRP 1569
Query: 251 GF 252
GF
Sbjct: 1570 GF 1571
Score = 38.5 bits (88), Expect = 0.030
Identities = 23/77 (29%), Positives = 32/77 (41%), Gaps = 12/77 (15%)
Query: 113 CNHGGCQEVARV----CPVGFSMTETAVGIRCTDIDECVTSSC------EGHCVNTEGGF 162
C +G C V C G+ + T + C DI+EC + C+NT+G F
Sbjct: 1506 CTNGRCVRVPEGFTCRCFDGYRLDMTRMA--CVDINECDEAEAASPLCVNARCLNTDGSF 1563
Query: 163 VCECGPGMQLSADRHSC 179
C C PG + H C
Sbjct: 1564 RCICRPGFAPTHQPHHC 1580
>gi|110347431 latent transforming growth factor beta binding protein
4 isoform a [Homo sapiens]
Length = 1624
Score = 116 bits (290), Expect = 1e-25
Identities = 96/264 (36%), Positives = 111/264 (42%), Gaps = 43/264 (16%)
Query: 17 PGAPARGYTGRKPPGHFAAERRRLGPHVCLSGF-GSGC------CPGWAPSMGGGHCTLP 69
PG RG + PG F VC +GF GS C C P G G C
Sbjct: 679 PGLCGRGAC-KNLPGSFRC--------VCPAGFRGSACEEDVDECAQEPPPCGPGRCDNT 729
Query: 70 LCSFGCG--SGICIAPNVCSCQDGEQGATCPETHGPCGEYGCDLTCNHGGCQEVARVCPV 127
SF C +G CQD ++ A P PC C+ T C VCP+
Sbjct: 730 AGSFHCACPAGFRSRGPGAPCQDVDECARSPP---PCTYGRCENTEGSFQC-----VCPM 781
Query: 128 GFSMTETAVGIRCTDIDECVTS-SCEGH-CVNTEGGFVCE-CGPGMQLSADRHSCQDTDE 184
GF G C D+DEC +C G CVN+ G F C C G L R C D DE
Sbjct: 782 GFQ--PNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGR--CTDVDE 837
Query: 185 CLG--TPC--QQRCKNSIGSYKCSCRTGFHLHGNRHS-CVDVNECRRPLERRVC--HHSC 237
C PC C N+ GS++CSC G+ R C DVNEC LE C H C
Sbjct: 838 CSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNEC---LEGDFCFPHGEC 894
Query: 238 HNTVGSFLCTCRPGFRLRADRVSC 261
NT GSF CTC PG+R SC
Sbjct: 895 LNTDGSFACTCAPGYRPGPRGASC 918
Score = 110 bits (276), Expect = 5e-24
Identities = 82/241 (34%), Positives = 104/241 (43%), Gaps = 26/241 (10%)
Query: 41 GPHVCLSGFGSGCCPGWAPSMGGGHCTLPLCSF--GCGSGICIAPNVCSCQDGEQGATCP 98
GP + SG SG C G G C + C SG ++P C D ++ C
Sbjct: 536 GPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDE---CR 592
Query: 99 ETHGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDEC--VTSSCE-GHC 155
PC C+ + C VC GF A C D+DEC V C+ G C
Sbjct: 593 RVPPPCAPGRCENSPGSFRC-----VCGPGFRAGPRAA--ECLDVDECHRVPPPCDLGRC 645
Query: 156 VNTEGGFVCECGPGMQLSADRHSCQDTDECLGTP--C-QQRCKNSIGSYKCSCRTGFHLH 212
NT G F+C C G Q + SCQD DEC +P C + CKN GS++C C GF
Sbjct: 646 ENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGF--- 702
Query: 213 GNRHSC-VDVNECRRPLERRVCHHS-CHNTVGSFLCTCRPGFRLRADRVSCEAFPKAVLA 270
+C DV+EC + E C C NT GSF C C GFR R C+ + +
Sbjct: 703 -RGSACEEDVDECAQ--EPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARS 759
Query: 271 P 271
P
Sbjct: 760 P 760
Score = 110 bits (275), Expect = 6e-24
Identities = 95/305 (31%), Positives = 112/305 (36%), Gaps = 83/305 (27%)
Query: 29 PPGHFAAERRRLGPHVCLSGFGSGCCPGWAPSMGGGHCTLPLCSFG-CGSGICIAPNV-- 85
PP G +C+ G P A CT S G CG G C N+
Sbjct: 638 PPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQ---SPGLCGRGAC--KNLPG 692
Query: 86 ---CSCQDGEQGATCPETHG-------PCGEYGCDLTCNHGGCQEVARVCPVGFSMTETA 135
C C G +G+ C E PCG CD T C CP GF
Sbjct: 693 SFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHC-----ACPAGFR--SRG 745
Query: 136 VGIRCTDIDECVTSS---CEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDEC---LGTP 189
G C D+DEC S G C NTEG F C C G Q + C+D DEC L P
Sbjct: 746 PGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACP 805
Query: 190 CQQRCKNSIGSYKC-SCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTC 248
Q+ C NS GS++C +C +G HLH R C DV+EC H C NT GSF C+C
Sbjct: 806 GQE-CVNSPGSFQCRTCPSGHHLHRGR--CTDVDECSSGAPPCGPHGHCTNTEGSFRCSC 862
Query: 249 RPGFRLRADRVSCEAFPKAVLAPSAILQPRQHPSKMLLLLPEAGRPALSPGHSPPSGAPG 308
+PG+ PSG PG
Sbjct: 863 ------------------------------------------------APGYRAPSGRPG 874
Query: 309 PPAGV 313
P A V
Sbjct: 875 PCADV 879
Score = 92.0 bits (227), Expect = 2e-18
Identities = 98/329 (29%), Positives = 122/329 (37%), Gaps = 78/329 (23%)
Query: 42 PH-VCLSGFGS---GCCPGWAPSMGGGHCT-LPLCSFG--CGSGICI------------- 81
PH CL+ GS C PG+ P G C + CS C SGIC
Sbjct: 890 PHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPG 949
Query: 82 ---APNVCSCQDGEQGATCPETHGP--CGEYGCDLTCNHGGCQEVARVCPVGFSMTETAV 136
P++ SC D ++ C E GP CG C+ N G R C G+
Sbjct: 950 HRAGPDLASCLDVDE---CRE-RGPALCGSQRCE---NSPGSYRCVRDCDPGYHAGPEGT 1002
Query: 137 GIRCTDIDECVTSSCE----GHCVNTEGGFVCE--CGPGMQLSADRHSCQDTDECLGTP- 189
C D+DEC E C NT G + C C PG Q + CQD DEC
Sbjct: 1003 ---CDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGG-GCQDVDECRNRSF 1058
Query: 190 --CQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHS-CHNTVGSFLC 246
C+N GS++C C G+ + CVDVNEC + VC + C N GSFLC
Sbjct: 1059 CGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECE--TLQGVCGAALCENVEGSFLC 1116
Query: 247 TCRPGFRLRADRVSCEAFPKAVLAPSAILQPRQHPSKMLLLLPEAGRPALSPGHSPPSGA 306
C P D ++ P P S G P S
Sbjct: 1117 VC-PNSPEEFDPMTGRCVP----------------------------PRTSAGTFPGSQP 1147
Query: 307 PGPPAGVRTTR-LPSPTPRLPTSSPSAPV 334
P + V R P P PR P++ PV
Sbjct: 1148 QAPASPVLPARPPPPPLPRRPSTPRQGPV 1176
Score = 91.3 bits (225), Expect = 4e-18
Identities = 76/268 (28%), Positives = 102/268 (38%), Gaps = 50/268 (18%)
Query: 17 PGAPARGY---TGRKPPGHFAAERRRLGPHVCLSGFGSGCCPGWAPSMGGGHCT-LPLCS 72
PGAP + PP + G C+ C G+ P+ G C + C
Sbjct: 746 PGAPCQDVDECARSPPPCTYGRCENTEGSFQCV------CPMGFQPNTAGSECEDVDECE 799
Query: 73 --FGCGSGICI-APNVCSCQDGEQGATCPETHG-----------------PCGEYG-CDL 111
C C+ +P C+ TCP H PCG +G C
Sbjct: 800 NHLACPGQECVNSPGSFQCR------TCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTN 853
Query: 112 TCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECVTSSC---EGHCVNTEGGFVCECGP 168
T C C G+ G C D++EC+ G C+NT+G F C C P
Sbjct: 854 TEGSFRCS-----CAPGYRAPSGRPG-PCADVNECLEGDFCFPHGECLNTDGSFACTCAP 907
Query: 169 GMQLSADRHSCQDTDECLGTP-CQQR-CKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRR 226
G + SC D DEC CQ C N+ GS++C C G + SC+DV+ECR
Sbjct: 908 GYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRE 967
Query: 227 PLERRVCHHSCHNTVGSFLCT--CRPGF 252
C N+ GS+ C C PG+
Sbjct: 968 RGPALCGSQRCENSPGSYRCVRDCDPGY 995
Score = 72.4 bits (176), Expect = 2e-12
Identities = 143/623 (22%), Positives = 198/623 (31%), Gaps = 148/623 (23%)
Query: 56 GWAPSMGGGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGATCPETHGPCGEYGCDLTCNH 115
G++ + G G+C L C S + P + + Q C G + C L
Sbjct: 279 GYSDASGFGYCFRELRGGECASPL---PGLRT-----QEVCCRGAGLAWGVHDCQLCSER 330
Query: 116 GGCQEVARV----CPVGFSMTETAVGIRCTDIDECVTSS-CE-GHCVNTEGGFVCECGPG 169
G E CP GF + C D+DEC T C+ G C NT GG+ C C G
Sbjct: 331 LGNSERVSAPDGPCPTGFERVNGS----CEDVDECATGGRCQHGECANTRGGYTCVCPDG 386
Query: 170 MQLSADRHSCQDTDECLGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLE 229
L + R SC + + + + C + CS R +
Sbjct: 387 FLLDSSRSSC--ISQHVISEAKGPCFRVLRDGGCSL-----------------PILRNIT 427
Query: 230 RRVCHHSCHNTVGSFL---CTCRPGFRLRADRVSCEAFPKAVLAPSAI---LQP-RQHPS 282
+++C C + VG C P F R C A P + S + +P Q P
Sbjct: 428 KQIC---CCSRVGKAWGRGCQLCPPFGSEGFREICPAGPGYHYSASDLRYNTRPLGQEPP 484
Query: 283 KMLL----LLPEAGRPALS--PGHS-PPSGAPGPPAGVRTTRLPSPTPRLPTSSPSAPVW 335
++ L LP RP+ P H P P P P P P LP PS P W
Sbjct: 485 RVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPD--------PRPGPELPL--PSIPAW 534
Query: 336 LLSTLLATPVPTASLLGNLRPPSLLQGEVMGTPSSPRGPESPRLAAGPSPCWHLGAMHES 395
+P + PSS +P++ GP C
Sbjct: 535 -----TGPEIPESG------------------PSSGMCQRNPQV-CGPGRC--------- 561
Query: 396 RSRWTEPGCSQCWCEDG-KVTCEKVRC--EAACSHPIPSRDGGCCPSCTGCFHSGVVRAE 452
+ P C C+ G +++ + RC C P G C + G F V
Sbjct: 562 ---ISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFR--CVCGP 616
Query: 453 GDVFSPPNENCTVCVCLAGNVSCISPECPSGPCQTPPQTDCCTCVPVRCYFHGRWYADGA 512
G P C + P C G C+ P + C C G A
Sbjct: 617 GFRAGPRAAECLD----VDECHRVPPPCDLGRCENTPGSFLCVCPA------GYQAAPHG 666
Query: 513 VFSGGGDECTTCVCQNGEVECSFMP------CPE-----------LACPREEWRLGPGQC 555
DECT G C +P CP C +E GPG+C
Sbjct: 667 ASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRC 726
Query: 556 -----CFTCQEPT------PSTGCSLDDNGVEFPIGQIWSPGDPCE---LCICQADGSVS 601
F C P P C D P + + E C+C +
Sbjct: 727 DNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPN 786
Query: 602 CKRTDC--VDSCPHPIRIPGQCC 622
++C VD C + + PGQ C
Sbjct: 787 TAGSECEDVDECENHLACPGQEC 809
Score = 67.0 bits (162), Expect = 8e-11
Identities = 62/200 (31%), Positives = 76/200 (38%), Gaps = 19/200 (9%)
Query: 142 DIDECVT---SSCE-GHCVNTEGGFVCECGPGMQLSADRHSCQDTDECLG--TPCQ-QRC 194
D+DEC C+ G CVNT G+ C C G R C D DEC C+ RC
Sbjct: 1253 DVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRC 1312
Query: 195 KNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTCRPGFRL 254
N++GSY C+C L G++ CV NE + L+ + C VG+ L P
Sbjct: 1313 VNTVGSYHCTCEPPLVLDGSQRRCVS-NE-SQSLDDNL--GVCWQEVGADLVCSHPRLDR 1368
Query: 255 RADRVSCEAFPKAVLAPSAILQPRQHPSKMLLLLPEAGRPALSPGHSPPSGAP---GPPA 311
+A C L P Q L PA SP G P GP
Sbjct: 1369 QATYTECCCLYGEAWGMDCALCPAQDSDDFEALCNVLRPPAYSPPRPGGFGLPYEYGPDL 1428
Query: 312 GVRTTRLP-----SPTPRLP 326
G LP P P LP
Sbjct: 1429 GPPYQGLPYGPELYPPPALP 1448
Score = 54.7 bits (130), Expect = 4e-07
Identities = 30/85 (35%), Positives = 40/85 (47%), Gaps = 8/85 (9%)
Query: 142 DIDEC-VTSSC-EGHCVNTEGGFVCECGPGMQLSADRHSCQDTDEC----LGTP--CQQR 193
+ +EC + C G CV GF C C G +L R +C D +EC +P R
Sbjct: 1533 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1592
Query: 194 CKNSIGSYKCSCRTGFHLHGNRHSC 218
C N+ GS++C CR GF H C
Sbjct: 1593 CLNTDGSFRCICRPGFAPTHQPHHC 1617
Score = 51.6 bits (122), Expect = 3e-06
Identities = 26/62 (41%), Positives = 33/62 (53%), Gaps = 2/62 (3%)
Query: 193 RCKNSIGSYKCSCRTGFHLHGNRHSCVDVNEC-RRPLERRVCHHS-CHNTVGSFLCTCRP 250
RC + C C G+ L R +CVD+NEC +C ++ C NT GSF C CRP
Sbjct: 1547 RCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRP 1606
Query: 251 GF 252
GF
Sbjct: 1607 GF 1608
Score = 38.5 bits (88), Expect = 0.030
Identities = 23/77 (29%), Positives = 32/77 (41%), Gaps = 12/77 (15%)
Query: 113 CNHGGCQEVARV----CPVGFSMTETAVGIRCTDIDECVTSSC------EGHCVNTEGGF 162
C +G C V C G+ + T + C DI+EC + C+NT+G F
Sbjct: 1543 CTNGRCVRVPEGFTCRCFDGYRLDMTRMA--CVDINECDEAEAASPLCVNARCLNTDGSF 1600
Query: 163 VCECGPGMQLSADRHSC 179
C C PG + H C
Sbjct: 1601 RCICRPGFAPTHQPHHC 1617
>gi|31377568 signal peptide, CUB domain, EGF-like 3 [Homo sapiens]
Length = 993
Score = 115 bits (289), Expect = 1e-25
Identities = 99/303 (32%), Positives = 126/303 (41%), Gaps = 52/303 (17%)
Query: 43 HVCLS----GFGSGCCPGWAPSMGGGHCTLPLCSFGCGSGICIAPNVC--SCQDGEQGAT 96
H+C G C PG+ + C L C++G G C +C D EQG
Sbjct: 170 HICRETPKGGIACECRPGFELTKNQRDCKLT-CNYGNGG--------CQHTCDDTEQGPR 220
Query: 97 CP-------ETHGP-CGEY------GCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTD 142
C T G C E GCD C H V CPVGF + C D
Sbjct: 221 CGCHIKFVLHTDGKTCIETCAVNNGGCDSKC-HDAATGVHCTCPVGFMLQPDRK--TCKD 277
Query: 143 IDECVTSS--CEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDEC-LGTPCQQRCKNSIG 199
IDEC ++ C+ C NT G F C C G +L + +CQD DEC C C N+ G
Sbjct: 278 IDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDECSFDRTCDHICVNTPG 337
Query: 200 SYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTCRPG-FRLR--- 255
S++C C G+ L+G H C DV+EC + R C C NT GS+ CTC G RL
Sbjct: 338 SFQCLCHRGYLLYGITH-CGDVDEC--SINRGGCRFGCINTPGSYQCTCPAGQGRLHWNG 394
Query: 256 ---ADRVSCEAFPKAVLAPSAILQPRQHPSK--MLLLLPEAGR--PALSPGHSPPSGAPG 308
+ + C+ P A A+L + K L P R P G + G P
Sbjct: 395 KDCTEPLKCQGSPG---ASKAMLSCNRSGKKDTCALTCPSRARFLPESENGFTVSCGTPS 451
Query: 309 PPA 311
P A
Sbjct: 452 PRA 454
Score = 108 bits (269), Expect = 3e-23
Identities = 60/159 (37%), Positives = 76/159 (47%), Gaps = 20/159 (12%)
Query: 118 CQEVAR----VCPVGFSMTETAVGIRCTDIDECV---TSSCEGHCVNTEGGFVCECGPGM 170
CQ R +C G+ T G C D+DEC + C CVN G + C C G
Sbjct: 46 CQNTPRSYKCICKSGY----TGDGKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGF 101
Query: 171 QLSADRHSCQDTDECL--GTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNE----C 224
L+ D H+C D DEC CQQ C N +GSY+C CR GF L N+H+C+ E C
Sbjct: 102 HLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNC 161
Query: 225 RRPLERRVCHHSCHNT-VGSFLCTCRPGFRLRADRVSCE 262
+ C H C T G C CRPGF L ++ C+
Sbjct: 162 MN--KNHGCAHICRETPKGGIACECRPGFELTKNQRDCK 198
Score = 97.4 bits (241), Expect = 5e-20
Identities = 64/219 (29%), Positives = 93/219 (42%), Gaps = 18/219 (8%)
Query: 45 CLSGFGSGCCPGWAPSMGGGHCTLPLCSFGCGSGICIAPNVCSC-QDGEQGATCPETHGP 103
C G G GC MG C C G ++ N +C Q E+G C +
Sbjct: 116 CAEGNG-GCQQSCVNMMGSYECH-------CREGFFLSDNQHTCIQRPEEGMNCMNKN-- 165
Query: 104 CGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECVTSSCEGHCVNTEGGFV 163
+GC C +A C GF +T+ + T C+ C +TE G
Sbjct: 166 ---HGCAHICRETPKGGIACECRPGFELTKNQRDCKLTC--NYGNGGCQHTCDDTEQGPR 220
Query: 164 CECGPGMQLSADRHSCQDTDECLGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNE 223
C C L D +C +T C +C ++ C+C GF L +R +C D++E
Sbjct: 221 CGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDE 280
Query: 224 CRRPLERRVCHHSCHNTVGSFLCTCRPGFRLRADRVSCE 262
CR L C H C NTVGSF C+C+ G++L + +C+
Sbjct: 281 CR--LNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQ 317
Score = 90.5 bits (223), Expect = 7e-18
Identities = 50/132 (37%), Positives = 69/132 (52%), Gaps = 11/132 (8%)
Query: 142 DIDECV--TSSC--EGHCVNTEGGFVCECGPGMQLSADRHSCQDTDECL---GTPCQQRC 194
D+DECV T +C + C NT + C C G + D C+D DEC C C
Sbjct: 29 DVDECVEGTDNCHIDAICQNTPRSYKCICKSGY--TGDGKHCKDVDECEREDNAGCVHDC 86
Query: 195 KNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTCRPGFRL 254
N G+Y+C+C GFHL + H+C+DV+EC C SC N +GS+ C CR GF L
Sbjct: 87 VNIPGNYRCTCYDGFHLAHDGHNCLDVDECAE--GNGGCQQSCVNMMGSYECHCREGFFL 144
Query: 255 RADRVSCEAFPK 266
++ +C P+
Sbjct: 145 SDNQHTCIQRPE 156
>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
Length = 1541
Score = 112 bits (279), Expect = 2e-24
Identities = 66/195 (33%), Positives = 94/195 (48%), Gaps = 21/195 (10%)
Query: 75 CGSGICIAPNVCSCQDGEQGATCPETHGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTET 134
C G +A + +C+D ++ C C +GC T C VC G+ +
Sbjct: 270 CHVGYQLAADGKACEDVDE---CAAGLAQCA-HGCLNTQGSFKC-----VCHAGYELG-- 318
Query: 135 AVGIRCTDIDECVTSSCEGH-------CVNTEGGFVCECGPGMQLSADRHSCQDTDECLG 187
A G +C I+ + +SCE + C +T G +C C G +L D+ +C D D+C
Sbjct: 319 ADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCIDVDDCAD 378
Query: 188 TP-CQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLC 246
+P CQQ C N+ G Y+C C G+ L + C DV+EC R C H C N GSF C
Sbjct: 379 SPCCQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDECAS--SRGGCEHHCTNLAGSFQC 436
Query: 247 TCRPGFRLRADRVSC 261
+C G+RL DR C
Sbjct: 437 SCEAGYRLHEDRRGC 451
Score = 100 bits (249), Expect = 6e-21
Identities = 74/248 (29%), Positives = 104/248 (41%), Gaps = 38/248 (15%)
Query: 43 HVCLSGFGSGCC---PGWAPSMGGGHCTLPLCSFGCGSGIC--------IAPNVCSCQDG 91
H C++ GS C PG+ C L + S G+G C I + C C+ G
Sbjct: 174 HRCVNTPGSYLCECKPGFRLHTDSRTC-LAINSCALGNGGCQHHCVQLTITRHRCQCRPG 232
Query: 92 ----EQGATCPETHGPCGEYGCDLTCNHGGCQEVARV----CPVGFSMTETAVGIRCTDI 143
E G C PC +C H CQ V + C VG+ + A G C D+
Sbjct: 233 FQLQEDGRHCVR-RSPCANRNG--SCMHR-CQVVRGLARCECHVGYQLA--ADGKACEDV 286
Query: 144 DECVT--SSCEGHCVNTEGGFVCECGPGMQLSADRHSCQDTD-------ECLGTPCQQRC 194
DEC + C C+NT+G F C C G +L AD C + E C C
Sbjct: 287 DECAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGC 346
Query: 195 KNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTCRPGFRL 254
++ C+C G+ L ++ +C+DV++C + C C N G + C C G+RL
Sbjct: 347 SHTSAGPLCTCPRGYELDTDQRTCIDVDDCA---DSPCCQQVCTNNPGGYECGCYAGYRL 403
Query: 255 RADRVSCE 262
AD CE
Sbjct: 404 SADGCGCE 411
Score = 96.7 bits (239), Expect = 9e-20
Identities = 82/268 (30%), Positives = 100/268 (37%), Gaps = 66/268 (24%)
Query: 53 CCPGWA--PSMGG---GHCTLPLCSFGCGSGICIAPNV--CSCQDGEQGATCP------E 99
CC GW P G C+ LC G G C+ + C C G QG C
Sbjct: 110 CCRGWMQQPDEEGCLSAECSASLCFHG---GRCVPGSAQPCHCPPGFQGPRCQYDVDECR 166
Query: 100 TH-GPC--------GEYGCDL-----------TC--------NHGGCQE------VAR-- 123
TH G C G Y C+ TC +GGCQ + R
Sbjct: 167 THNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITRHR 226
Query: 124 -VCPVGFSMTETAVGIRCTDIDECVT--SSCEGHCVNTEGGFVCECGPGMQLSADRHSCQ 180
C GF + E G C C SC C G CEC G QL+AD +C+
Sbjct: 227 CQCRPGFQLQED--GRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACE 284
Query: 181 DTDECLG--TPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVD-----VNECRRPLERRVC 233
D DEC C C N+ GS+KC C G+ L + C VN C C
Sbjct: 285 DVDECAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCE--ANNGGC 342
Query: 234 HHSCHNTVGSFLCTCRPGFRLRADRVSC 261
H C +T LCTC G+ L D+ +C
Sbjct: 343 SHGCSHTSAGPLCTCPRGYELDTDQRTC 370
Score = 89.7 bits (221), Expect = 1e-17
Identities = 55/169 (32%), Positives = 75/169 (44%), Gaps = 18/169 (10%)
Query: 68 LPLCSFGC----GSGICIAPNVCSCQDGEQGATC----PETHGPC--GEYGCDLTCNHGG 117
L C+ GC GS C+ + G G C E C GC C+H
Sbjct: 293 LAQCAHGCLNTQGSFKCVCH--AGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTS 350
Query: 118 CQEVARVCPVGFSMTETAVGIRCTDIDECVTSSC-EGHCVNTEGGFVCECGPGMQLSADR 176
+ CP G+ + C D+D+C S C + C N GG+ C C G +LSAD
Sbjct: 351 AGPLC-TCPRGYELDTDQR--TCIDVDDCADSPCCQQVCTNNPGGYECGCYAGYRLSADG 407
Query: 177 HSCQDTDECLGTP--CQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNE 223
C+D DEC + C+ C N GS++CSC G+ LH +R C + E
Sbjct: 408 CGCEDVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEE 456
Score = 79.3 bits (194), Expect = 2e-14
Identities = 52/148 (35%), Positives = 66/148 (44%), Gaps = 25/148 (16%)
Query: 132 TETAVGIRCT-------DIDECVTSSCE-------GHCVNTEGGFVCECGPGMQLSADRH 177
TE +RC D + C+++ C G CV C C PG Q
Sbjct: 102 TEARTVLRCCRGWMQQPDEEGCLSAECSASLCFHGGRCVPGSAQ-PCHCPPGFQ----GP 156
Query: 178 SCQ-DTDECL--GTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCH 234
CQ D DEC CQ RC N+ GSY C C+ GF LH + +C+ +N C L C
Sbjct: 157 RCQYDVDECRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSC--ALGNGGCQ 214
Query: 235 HSC-HNTVGSFLCTCRPGFRLRADRVSC 261
H C T+ C CRPGF+L+ D C
Sbjct: 215 HHCVQLTITRHRCQCRPGFQLQEDGRHC 242
Score = 63.2 bits (152), Expect = 1e-09
Identities = 74/260 (28%), Positives = 90/260 (34%), Gaps = 43/260 (16%)
Query: 29 PPGHFAAERRRLGPHVCLSGF-GSGCCPGWAPSMGGGHCTLPLCSFGCGSGICIAPNVCS 87
PPG AA G C GF GSGC P G C G A CS
Sbjct: 1135 PPG--AACHHVTGACRCPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTCS 1192
Query: 88 CQDGEQGATCPETHGPCGEYG--CDLTC---NHGGCQEVARVC--PVGFSMTETAVGIRC 140
C G G +C + P G YG C+ C N G C C P GF T+ +
Sbjct: 1193 CAAGYHGPSCQQRCPP-GRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNL---- 1247
Query: 141 TDIDECVTSSCEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDECLGTPCQQRC-KNSIG 199
C +C + VC CG G +C G C++ C +N G
Sbjct: 1248 ----TCPQGRFGPNCTH-----VCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFG 1298
Query: 200 ---SYKCSCRTGFHLHGNRHSC-VDVNECRRPLERR--------VCHH--SCHNTV---- 241
+ CSCR G H + SC + R E CH SCHN
Sbjct: 1299 VGCEHTCSCRNGGLCHASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEP 1358
Query: 242 GSFLCTCRPGFRLRADRVSC 261
+ C C PGF +A C
Sbjct: 1359 ATGTCRCGPGFYGQACEHPC 1378
Score = 61.2 bits (147), Expect = 4e-09
Identities = 171/716 (23%), Positives = 217/716 (30%), Gaps = 156/716 (21%)
Query: 23 GYTGRK-----PPGHFA--AERRRLGPHVCLSGFGSGCCP---GWAPSMGGGHCTLPLCS 72
GY G + P GHF E+R H SG C GW + C
Sbjct: 894 GYVGPRCEQQCPQGHFGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGFFG 953
Query: 73 FGCGSGI-------CIAPN-VCSCQDGEQGATCPETHGPCGEYG--CDLTCN-------- 114
C S C A N C C G +G C ET P YG C C
Sbjct: 954 LDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAETC-PAHTYGHNCSQACACFNGASCD 1012
Query: 115 --HGGCQ--------EVARVCPVGFSMTETAVGIRCTDIDECVTSSCEGHCVNTEG--GF 162
HG C + CP G C + C S GHC EG G
Sbjct: 1013 PVHGQCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVS--GHCACPEGWAGL 1070
Query: 163 VCE--CGPGMQLSADRHSCQDTDECLGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVD 220
CE C P + RHS + L P RC G C++ +C
Sbjct: 1071 ACEKECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQ 1130
Query: 221 VNECRRPLERRVCHHSCHNTVGSFLCTCRPGFRLRADRVSCEAFPKAVLAPSAILQPRQH 280
C +CH+ G+ C C PGF +C P Q Q
Sbjct: 1131 RCSCPPGA-------ACHHVTGA--CRCPPGFTGSGCEQAC---PPGSFGEDCA-QMCQC 1177
Query: 281 PSKMLLLLPEAGRPALSPGHSPPSGAPGPPAGVRTTRLPSPTPRLPTSSPSAPVWLLSTL 340
P + P G + + G+ PS P G L S A
Sbjct: 1178 PGENPACHPATGTCSCAAGYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATG----- 1232
Query: 341 LATPVPTASLLGNLRPPSLLQGEVMGTPSSPRGPESPRLAAGPSPCWHLGAMHESRSRWT 400
A PT L GT + P+ GP+ C H+ + +
Sbjct: 1233 -ACRCPTGFL---------------GTDCNLTCPQG---RFGPN-CTHVCGCGQGAA--C 1270
Query: 401 EPGCSQCWCEDGK--VTCEKV----RCEAACSHPIPSRDGGCCPSCTGCFHSGV--VRAE 452
+P C C G+ V CE+ R C H R+GG C + G G+
Sbjct: 1271 DPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGLCHASNGSCSCGLGWTGRH 1330
Query: 453 GDVFSPPNENCTVCVCLAGNVSCISPECPSGPCQTPPQTDCCTCVPVRCYFHGRWYADGA 512
++ PP C SC + + C+ P T C C P Y +
Sbjct: 1331 CELACPPGRYGAACHL---ECSCHN----NSTCE--PATGTCRCGP-GFYGQACEHPCPP 1380
Query: 513 VFSGGGDECTTCVCQNGEVECSFMPCPELACPREEWRLGPGQCCFTCQEPTPSTGCSLDD 572
F G G + C CQ+G PC ++ G+C C C +
Sbjct: 1381 GFHGAGCQ-GLCWCQHG------APCDPIS----------GRC--LCPAGFHGHFC---E 1418
Query: 573 NGVEFPIGQIWSPGDPCELC--ICQADGSVSCKRTDCVDSCPHPIRIPGQCCPDCSAGCT 630
G E PG E C C DG C + CP P R C DC G
Sbjct: 1419 RGCE--------PGSFGEGCHQRCDCDGGAPCDPVTGLCLCP-PGRSGATCNLDCRRG-- 1467
Query: 631 YTGRIFYNNETFPSVLDPCLSCICLLGSVACSPVDCPITCTYPFHPDGECCPVCRD 686
+ PS L C C G C PV C DG P CR+
Sbjct: 1468 ---------QFGPSC---TLHCDC-GGGADCDPVSGQCHCV-----DGYMGPTCRE 1505
Score = 60.5 bits (145), Expect = 7e-09
Identities = 42/113 (37%), Positives = 49/113 (43%), Gaps = 7/113 (6%)
Query: 158 TEGGFVCECGPGMQLSADRHSCQDTDECLGTPCQQRCKNSIGSYK-CSCRTGFHLHGNRH 216
TE V C G D C EC + C + GS + C C GF G R
Sbjct: 102 TEARTVLRCCRGWMQQPDEEGCLSA-ECSASLCFHGGRCVPGSAQPCHCPPGFQ--GPRC 158
Query: 217 SCVDVNECRRPLERRVCHHSCHNTVGSFLCTCRPGFRLRADRVSCEAFPKAVL 269
DV+ECR C H C NT GS+LC C+PGFRL D +C A L
Sbjct: 159 Q-YDVDECRT--HNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCAL 208
Score = 58.9 bits (141), Expect = 2e-08
Identities = 73/267 (27%), Positives = 86/267 (32%), Gaps = 42/267 (15%)
Query: 21 ARGYTG-----RKPPGHFAAERRRL-------------GPHVCLSGF-GSGCCPGWAPSM 61
A GY G R PPG + +L G C +GF G+ C
Sbjct: 1194 AAGYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQGR 1253
Query: 62 GGGHCTLPLCSFGCGSGICIAP--NVCSCQDGEQGATCPETHGPCGEYG--CDLTC---N 114
G +CT +C GCG G P C C G G C E P +G C+ TC N
Sbjct: 1254 FGPNCT-HVC--GCGQGAACDPVTGTCLCPPGRAGVRC-ERGCPQNRFGVGCEHTCSCRN 1309
Query: 115 HGGCQEVARVCPVGFSMTETAVGIRCTDIDECVTSSCEGHCVNTE----GGFVCECGPGM 170
G C C G T + C E C N C CGPG
Sbjct: 1310 GGLCHASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGF 1369
Query: 171 QLSADRHSCQDTDECLGTPCQQRCKNSIG------SYKCSCRTGFHLHGNRHSCVDVNEC 224
A H C G CQ C G S +C C GFH H C +
Sbjct: 1370 YGQACEHPCPPGFH--GAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCERGCEPGSFG 1427
Query: 225 RRPLERRVCHHSCHNTVGSFLCTCRPG 251
+R C + LC C PG
Sbjct: 1428 EGCHQRCDCDGGAPCDPVTGLCLCPPG 1454
Score = 50.8 bits (120), Expect = 6e-06
Identities = 73/309 (23%), Positives = 91/309 (29%), Gaps = 75/309 (24%)
Query: 18 GAPARGYTG--RKPPG---------------------------HFAAERRRLGPHVCLSG 48
GAP G TG R PPG H A G +CL G
Sbjct: 748 GAPCHGVTGQCRCPPGRTGEDCEADCPEGRWGLGCQEICPACQHAARCDPETGACLCLPG 807
Query: 49 FGSGCCPGWAPSMGGGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGATCPET-----HGP 103
F C P+ G CS A CSC G G +C GP
Sbjct: 808 FVGSRCQDVCPAGWYGPSCQTRCSCANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGP 867
Query: 104 CGEYGCDLTCNHGGCQEVAR--VCPVGFSMTETAVGIRCTDIDECVTS----SCEGHCVN 157
+ C+ + HG C ++ +C G+ VG RC +C CE C
Sbjct: 868 DCSHPCNCSAGHGSCDAISGLCLCEAGY------VGPRCE--QQCPQGHFGPGCEQRCQC 919
Query: 158 TEGGF------VCECGPGMQLSADRHSCQDTDECLGTPCQQRCKNSIGSY------KCSC 205
G C C G + + H+C G C+ C + G+ C C
Sbjct: 920 QHGAACDHVSGACTCPAGWRGTFCEHAC--PAGFFGLDCRSACNCTAGAACDAVNGSCLC 977
Query: 206 RTGFH---------LHGNRHSCVDVNECRRPLERRVCHHSCHNTVG----SFLCTCRPGF 252
G H H+C C H CH G S L C G
Sbjct: 978 PAGRRGPRCAETCPAHTYGHNCSQACACFNGASCDPVHGQCHCAPGWMGPSCLQACPAGL 1037
Query: 253 RLRADRVSC 261
R SC
Sbjct: 1038 YGDNCRHSC 1046
Score = 46.2 bits (108), Expect = 1e-04
Identities = 65/263 (24%), Positives = 79/263 (30%), Gaps = 45/263 (17%)
Query: 17 PGAPARGYTGRKPPGHFAAERRRL--------------GPHVCLSGF-GSGCCPGWAPSM 61
PG G PPG F + ++ G C +G+ G C P
Sbjct: 1151 PGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQRCPPGR 1210
Query: 62 GGGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGATCPETHGPCGEYG--CDLTCNHG--- 116
G C LC G A C C G G C T P G +G C C G
Sbjct: 1211 YGPGCE-QLCGCLNGGSCDAATGACRCPTGFLGTDCNLT-CPQGRFGPNCTHVCGCGQGA 1268
Query: 117 GCQEVAR--VCPVGFSMTETAVGIRCTDIDECVTSSCEGHCVNTEGGFVCECGPGMQLSA 174
C V +CP G G+RC C + C +T C C G A
Sbjct: 1269 ACDPVTGTCLCPPG------RAGVRCE--RGCPQNRFGVGCEHT-----CSCRNGGLCHA 1315
Query: 175 DRHSCQDTDECLGTPCQQRCKNSIGSYKCSCRTGFHLHGNR--HSCVDVNECRRPLERRV 232
SC G C+ C G Y +C H N C +
Sbjct: 1316 SNGSCSCGLGWTGRHCELACPP--GRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQA 1373
Query: 233 CHHSC----HNTVGSFLCTCRPG 251
C H C H LC C+ G
Sbjct: 1374 CEHPCPPGFHGAGCQGLCWCQHG 1396
Score = 43.9 bits (102), Expect = 7e-04
Identities = 54/191 (28%), Positives = 65/191 (34%), Gaps = 48/191 (25%)
Query: 44 VCLS-GFGSGCCPGWAPSMGGGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGATC----- 97
VCL FG C GG C L L + C C +G G C
Sbjct: 510 VCLDDSFGHDCSLTCDDCRNGGTCLLGL-------------DGCDCPEGWTGLICNETCP 556
Query: 98 PETHGPCGEYGCDLTCNHGG-CQEV--ARVCPVGFSMTETA-------VGIRCTDIDECV 147
P+T G + C +C +GG C V A CP G S T G C C
Sbjct: 557 PDTFGKNCSFSC--SCQNGGTCDSVTGACRCPPGVSGTNCEDGCPKGYYGKHCRKKCNCA 614
Query: 148 TSSCEGHCVNTEGGFVCECGPGMQLS---------ADRHSCQDTDECLGTPCQQRCKNSI 198
G C G C C PG+ A C + +C+ P Q C
Sbjct: 615 N---RGRCHRLYG--ACLCDPGLYGRFCHLTCPPWAFGPGCSEECQCV-QPHTQSCDKRD 668
Query: 199 GSYKCSCRTGF 209
GS CSC+ GF
Sbjct: 669 GS--CSCKAGF 677
Score = 42.0 bits (97), Expect = 0.003
Identities = 91/359 (25%), Positives = 113/359 (31%), Gaps = 75/359 (20%)
Query: 402 PGCSQCWCEDGKVTCEKVRCEAACSHPIPSRDGGCCPSCTGCFHSGVVRAEGDV--FSPP 459
PGCS E+ +C + RDG C SC F +AE ++ F P
Sbjct: 648 PGCS-----------EECQCVQPHTQSCDKRDGSC--SCKAGFRGERCQAECELGYFGP- 693
Query: 460 NENC-TVCVCLAGNVSC--ISPECPSGPCQTPPQTDCCTCVPVRCY---FHGRWYADGAV 513
C C C G V+C +S EC DC PV + GA
Sbjct: 694 --GCWQACTCPVG-VACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAP 750
Query: 514 FSGGGDECTTCVCQNGEVECSFMPCPELACPREEWRLGPGQCCFTCQEPT---PSTGCSL 570
G +C + GE +C E CP W LG + C CQ P TG L
Sbjct: 751 CHGVTGQCRCPPGRTGE-DC------EADCPEGRWGLGCQEICPACQHAARCDPETGACL 803
Query: 571 DDNGVEFPIGQIWSP----GDPCEL-CICQADGSVSCKRTDCVDSCPHPIRIPGQCCPDC 625
G Q P G C+ C C DG C + H PG C
Sbjct: 804 CLPGFVGSRCQDVCPAGWYGPSCQTRCSCANDG-------HCHPATGHCSCAPGWTGFSC 856
Query: 626 SAGCTYTGRIFYNNETFPSVLDPCLSCICLLGSVACSPVDCPITCTYPFHPDGECCPVCR 685
C P P C C G +C + C G P C
Sbjct: 857 QRACD-------TGHWGPDCSHP---CNCSAGHGSCDAISGLCLC-----EAGYVGPRCE 901
Query: 686 DCNYEGRKVANGQVFTLDDEPCTRCTCQLGEVSCEKVPCQRACADPALLPGDCCS-SCP 743
+G + RC CQ G +C+ V AC PA G C +CP
Sbjct: 902 QQCPQGHFGPGCE---------QRCQCQHG-AACDHV--SGACTCPAGWRGTFCEHACP 948
Score = 40.4 bits (93), Expect = 0.008
Identities = 50/204 (24%), Positives = 66/204 (32%), Gaps = 56/204 (27%)
Query: 88 CQDGEQGATCPETHGPCGEYGCDLTCNHG--GCQEVARVCPVGFSMTETAVGIRCTDIDE 145
C D G C T C G TC G GC CP G++ G+ C +
Sbjct: 511 CLDDSFGHDCSLTCDDCRNGG---TCLLGLDGCD-----CPEGWT------GLICNE--- 553
Query: 146 CVTSSCEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDECLGTPCQQRC-KNSIGSY--- 201
+C F C C G + +C+ GT C+ C K G +
Sbjct: 554 ----TCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCEDGCPKGYYGKHCRK 609
Query: 202 KCSCRTGFHLHGNRHSCVDVNECRRPLERRVCH-----------------------HSCH 238
KC+C H +C+ C L R CH SC
Sbjct: 610 KCNCANRGRCHRLYGACL----CDPGLYGRFCHLTCPPWAFGPGCSEECQCVQPHTQSCD 665
Query: 239 NTVGSFLCTCRPGFRLRADRVSCE 262
GS C+C+ GFR + CE
Sbjct: 666 KRDGS--CSCKAGFRGERCQAECE 687
Score = 39.3 bits (90), Expect = 0.018
Identities = 91/404 (22%), Positives = 115/404 (28%), Gaps = 130/404 (32%)
Query: 403 GCSQCWCEDG------KVTCEKVRCEAACSHPIPSRDGGCCPSCTGCFHSGVVRAEGDVF 456
G C C +G TC CS ++GG C S TG
Sbjct: 536 GLDGCDCPEGWTGLICNETCPPDTFGKNCSFSCSCQNGGTCDSVTGACR----------- 584
Query: 457 SPPNENCTVCVCLAGNVSCISPECPSGPCQTPPQTDCCTCVPVRCYFHGRWYADGAVFSG 516
PP + T C CP G + C RC+ R Y
Sbjct: 585 CPPGVSGTNC----------EDGCPKGYYGKHCRKKCNCANRGRCH---RLYG------- 624
Query: 517 GGDECTTCVCQNGEVECSFMPCPELACPREEWRLGPGQCCFTCQEPTPST-GCSLDDNGV 575
C+C G + L CP W GPG C CQ P T C D
Sbjct: 625 ------ACLCDPG----LYGRFCHLTCP--PWAFGPG-CSEECQCVQPHTQSCDKRDGSC 671
Query: 576 EFPIG----------QIWSPGDPC-ELCICQADGSVSCKRTDCVDSCPHPIRIP--GQCC 622
G ++ G C + C C + +C CP + GQ C
Sbjct: 672 SCKAGFRGERCQAECELGYFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDCGQEC 731
Query: 623 P------DCSAGCTYTGRIFYNNETFPSVLDPCLSCICLLGSVACSP----VDCPITCTY 672
P +CS+ C+ G C + G C P DC C
Sbjct: 732 PVGTFGVNCSSSCSCGG----------------APCHGVTGQCRCPPGRTGEDCEADC-- 773
Query: 673 PFHPDGE----CCPVCRDCNYEGR--------KVANGQVFTLDDEPC----------TRC 710
P+G C +C C + R G V + + C TRC
Sbjct: 774 ---PEGRWGLGCQEICPACQHAARCDPETGACLCLPGFVGSRCQDVCPAGWYGPSCQTRC 830
Query: 711 TC--------QLGEVSCEK----VPCQRACADPALLPGDCCSSC 742
+C G SC CQRAC D DC C
Sbjct: 831 SCANDGHCHPATGHCSCAPGWTGFSCQRAC-DTGHWGPDCSHPC 873
>gi|46249414 latent transforming growth factor beta binding protein 1
isoform LTBP-1L [Homo sapiens]
Length = 1722
Score = 111 bits (277), Expect = 4e-24
Identities = 80/237 (33%), Positives = 104/237 (43%), Gaps = 39/237 (16%)
Query: 62 GGGHCTLPLCSFGC---GSGI-------------CIAPNVC---SCQDGEQGATC-PETH 101
G GHC + +F C SG C+ P+ C C + C P T
Sbjct: 969 GEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTE 1028
Query: 102 GPCGEYGCDL---------TCNHGGCQ--EVARVCPVGFSMTETAVGIRCTDIDECVTSS 150
G G G L C +G C E + +C T T C DIDEC +
Sbjct: 1029 GFRGWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGN 1088
Query: 151 C--EGHCVNTEGGFVCECGPGMQLSADRHSCQDTDECLGTP--CQQRCKNSIGSYKCSCR 206
G C NTEG F C CG G QLSA + C+D DEC +C+N+ GS++C C
Sbjct: 1089 LCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCD 1148
Query: 207 TGFHLHGNRHSCVDVNECRRPLERRVCHH-SCHNTVGSFLCTCRPGFRLRADRVSCE 262
G+ G C D+NEC ++ VC C NT GS+ CTC GF+L D +C+
Sbjct: 1149 QGYRASGLGDHCEDINECLE--DKSVCQRGDCINTAGSYDCTCPDGFQL-DDNKTCQ 1202
Score = 108 bits (271), Expect = 2e-23
Identities = 75/212 (35%), Positives = 102/212 (48%), Gaps = 27/212 (12%)
Query: 80 CIAPNVCSCQD-----GEQGATCPE--THGPCGEYGCDLT-------CNHGGCQ--EVAR 123
C+ PNVC+ D G +C + T P ++ D+ C +G C+ E +
Sbjct: 1043 CLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSF 1102
Query: 124 VCPVGFSMTETAVGIRCTDIDECVTSS--CEGHCVNTEGGFVCECGPGMQLSADRHSCQD 181
C G +A +C DIDEC G C NTEG F C C G + S C+D
Sbjct: 1103 RCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCED 1162
Query: 182 TDECLG--TPCQQR-CKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVC--HHS 236
+ECL + CQ+ C N+ GSY C+C GF L N+ +C D+NEC P +C
Sbjct: 1163 INECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNK-TCQDINECEHP---GLCGPQGE 1218
Query: 237 CHNTVGSFLCTCRPGFRLRADRVSCEAFPKAV 268
C NT GSF C C+ GF + AD +CE + V
Sbjct: 1219 CLNTEGSFHCVCQQGFSISADGRTCEDIDECV 1250
Score = 108 bits (270), Expect = 2e-23
Identities = 80/249 (32%), Positives = 111/249 (44%), Gaps = 34/249 (13%)
Query: 40 LGPHVCLSG--------FGSGCCPGWAPSMGGGHCT-LPLCSFG--CGSGICIAPNV--- 85
L P+VC +G + C G+ + HC + C G C +G C
Sbjct: 1044 LEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFR 1103
Query: 86 CSCQDGEQGATCPETHGPCGEYGCDLTCNHGGCQEVAR----VCPVGFSMTETAVGIRCT 141
C+C G Q + + E C HG C+ VC G+ + +G C
Sbjct: 1104 CTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRAS--GLGDHCE 1161
Query: 142 DIDECVT--SSCE-GHCVNTEGGFVCECGPGMQLSADRHSCQDTDEC----LGTPCQQRC 194
DI+EC+ S C+ G C+NT G + C C G QL D +CQD +EC L P Q C
Sbjct: 1162 DINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLD-DNKTCQDINECEHPGLCGP-QGEC 1219
Query: 195 KNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVC--HHSCHNTVGSFLCTCRPGF 252
N+ GS+ C C+ GF + + +C D++EC + VC H C NT GSF C C GF
Sbjct: 1220 LNTEGSFHCVCQQGFSISADGRTCEDIDEC---VNNTVCDSHGFCDNTAGSFRCLCYQGF 1276
Query: 253 RLRADRVSC 261
+ D C
Sbjct: 1277 QAPQDGQGC 1285
Score = 105 bits (261), Expect = 3e-22
Identities = 59/147 (40%), Positives = 73/147 (49%), Gaps = 16/147 (10%)
Query: 113 CNHGGCQEVAR----VCPVGFSMTETAVGIRCTDIDECVTSSC---EGHCVNTEGGFVCE 165
C G C A CP GF + + C DI+EC +G C+NTEG F C
Sbjct: 1173 CQRGDCINTAGSYDCTCPDGFQLDDNKT---CQDINECEHPGLCGPQGECLNTEGSFHCV 1229
Query: 166 CGPGMQLSADRHSCQDTDECL-GTPCQQR--CKNSIGSYKCSCRTGFHLHGNRHSCVDVN 222
C G +SAD +C+D DEC+ T C C N+ GS++C C GF + CVDVN
Sbjct: 1230 CQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVN 1289
Query: 223 ECRRPLERRVCHHS-CHNTVGSFLCTC 248
EC L VC + C N GSFLC C
Sbjct: 1290 ECE--LLSGVCGEAFCENVEGSFLCVC 1314
Score = 84.3 bits (207), Expect = 5e-16
Identities = 52/141 (36%), Positives = 71/141 (50%), Gaps = 12/141 (8%)
Query: 130 SMTETAVGIRCTDIDECVTSS--C-EGHCVNTEGGFVCECGPGMQLSADRHSCQDTDECL 186
S ++ + T+I+EC + C GHC+N + C C G + S + C D DEC
Sbjct: 862 SASQVIAPTQVTEINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECT 921
Query: 187 GTP--CQQ-RCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHS-CHNTVG 242
C Q RC+N+ GS+ C C GF +C+DV+EC RP VC C NTVG
Sbjct: 922 QVQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRP---DVCGEGHCVNTVG 978
Query: 243 SFLCT-CRPGFRLRADRVSCE 262
+F C C G+R+ R CE
Sbjct: 979 AFRCEYCDSGYRM-TQRGRCE 998
Score = 82.4 bits (202), Expect = 2e-15
Identities = 50/138 (36%), Positives = 71/138 (51%), Gaps = 14/138 (10%)
Query: 124 VCPVGFSMTETAVGIRCTDIDEC--VTSSC-EGHCVNTEGGFVCECGPGMQLSADRHSCQ 180
+C G+ +E +C DIDEC V C +G C NTEG F+C C G S + +C
Sbjct: 900 ICYEGYRFSEQQR--KCVDIDECTQVQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCI 957
Query: 181 DTDECLGTPC--QQRCKNSIGSYKCS-CRTGFHLHGNRHSCVDVNECRRPLERRVC-HHS 236
D DECL + C N++G+++C C +G+ + R C D++EC P C
Sbjct: 958 DVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRM-TQRGRCEDIDECLNP---STCPDEQ 1013
Query: 237 CHNTVGSFLCT-CRPGFR 253
C N+ GS+ C C GFR
Sbjct: 1014 CVNSPGSYQCVPCTEGFR 1031
Score = 55.5 bits (132), Expect = 2e-07
Identities = 45/162 (27%), Positives = 61/162 (37%), Gaps = 20/162 (12%)
Query: 81 IAPNVCSCQDGEQGATCPETHGPCGEYGCDL-TCNHGGCQEVARVCPVGFSM------TE 133
+APNV + C T G C++ C G E +CP G +
Sbjct: 1364 LAPNVTKQE-------CCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSS 1416
Query: 134 TAVGIRCTDIDECVTSSCE----GHCVNTEGGFVCECGPGMQLSADRHSCQDTDECL--G 187
A G D DEC+ E G C+NT G+ C C G + C D DEC
Sbjct: 1417 EAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPS 1476
Query: 188 TPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLE 229
+ +C N+ GSY C C L + C+ E +E
Sbjct: 1477 SCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQIE 1518
Score = 53.1 bits (126), Expect = 1e-06
Identities = 27/87 (31%), Positives = 42/87 (48%), Gaps = 8/87 (9%)
Query: 144 DEC-VTSSCE-GHCVNTEGGFVCECGPGMQLSADRHSCQDTDEC------LGTPCQQRCK 195
+EC + + CE G CV + G+ C+C G L + +C D +EC + +C
Sbjct: 1624 EECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCI 1683
Query: 196 NSIGSYKCSCRTGFHLHGNRHSCVDVN 222
N+ GSYKC C G+ + C +N
Sbjct: 1684 NTDGSYKCLCLPGYVPSDKPNYCTPLN 1710
Score = 52.4 bits (124), Expect = 2e-06
Identities = 26/62 (41%), Positives = 34/62 (54%), Gaps = 2/62 (3%)
Query: 193 RCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLER-RVCHHS-CHNTVGSFLCTCRP 250
RC Y C C G+HL + +CVDVNEC R +C ++ C NT GS+ C C P
Sbjct: 1636 RCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLP 1695
Query: 251 GF 252
G+
Sbjct: 1696 GY 1697
Score = 50.4 bits (119), Expect = 8e-06
Identities = 22/58 (37%), Positives = 30/58 (51%), Gaps = 5/58 (8%)
Query: 41 GPHVCLSGFGSGCCPGWAPSMGGGHCTLPLCSFGC-GSGICIAPNVCSCQDGEQGATC 97
G +VC G CC GW+ + G CT P C C G+C+ P +C C+ G +G C
Sbjct: 165 GVNVC----GGRCCHGWSKAPGSQRCTKPSCVPPCQNGGMCLRPQLCVCKPGTKGKAC 218
Score = 46.2 bits (108), Expect = 1e-04
Identities = 36/112 (32%), Positives = 49/112 (43%), Gaps = 15/112 (13%)
Query: 165 ECGPGMQLSADRHSCQDTDECL--GTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVD-- 220
EC PG + + CQD +EC G C N++GSY+C+C+ GF SCV
Sbjct: 611 ECLPGYK-RVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDP 669
Query: 221 --VNECRRPLER-----RVCHHSCHNTVGSFLCTCRPGFRLRADRVSCEAFP 265
++E + P R R C H + LC C G +A CE P
Sbjct: 670 PVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVG---KAWGPHCEKCP 718
Score = 45.8 bits (107), Expect = 2e-04
Identities = 63/250 (25%), Positives = 89/250 (35%), Gaps = 45/250 (18%)
Query: 44 VCLSGF-----GSGCCPGWAPSMGGGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGATCP 98
+C GF G GC + G C C GS +C+ C D Q + P
Sbjct: 1271 LCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCV------CADENQEYS-P 1323
Query: 99 ETHGPCGEYGCDLTCNHGGCQEVARVCPVGF---SMTETAVGIRCTDIDECVTS------ 149
T DL + +E + C S+ + + T + C TS
Sbjct: 1324 MTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGD 1383
Query: 150 SCE-------GHCVNTEGGFVCECGPGMQLSADRHS------CQDTDECLGTPCQQRCKN 196
+CE G TE +C G G + + S +D DECL Q+ CKN
Sbjct: 1384 NCEIFPCPVLGTAEFTE---MCPKGKGFVPAGESSSEAGGENYKDADECLLFG-QEICKN 1439
Query: 197 SI-----GSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTCRPG 251
Y+C C+ G + + C D++EC+ P C NT GS+ C C
Sbjct: 1440 GFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSS--CIDGQCVNTEGSYNCFCTHP 1497
Query: 252 FRLRADRVSC 261
L A C
Sbjct: 1498 MVLDASEKRC 1507
Score = 40.4 bits (93), Expect = 0.008
Identities = 34/110 (30%), Positives = 46/110 (41%), Gaps = 10/110 (9%)
Query: 165 ECGPGMQ-LSADRHSCQDTDECLGTPCQQRC--KNSIGSYK--CSCRTGFHLHGNRHSCV 219
+CG + LS C G Q+C K S Y C G+ N C
Sbjct: 567 QCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPSYHGYNQMMECLPGYKRVNNTF-CQ 625
Query: 220 DVNECRRPLERRVCHHS-CHNTVGSFLCTCRPGFRLRADRVSCEAFPKAV 268
D+NEC+ + VC + C NT+GS+ CTC+ GF SC P +
Sbjct: 626 DINECQL---QGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVI 672
Score = 38.5 bits (88), Expect = 0.030
Identities = 157/765 (20%), Positives = 223/765 (29%), Gaps = 172/765 (22%)
Query: 140 CTDIDECVTSSC--EGHCVNTEGGFVCECGPGMQLSADRHSC--------QDTDECL--- 186
C DI+EC G C+NT G + C C G SC ++ C
Sbjct: 624 CQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGPCYRLV 683
Query: 187 --GTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSC-------------------VDVNECR 225
G C + C C G + C V R
Sbjct: 684 SSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKCPLPGTAAFKEICPGGMGYTVSGVHRR 743
Query: 226 RPLERRV----CHHSCHNTVGSFLCTCRPGFRLRADRVSCEAF----------PKAVLAP 271
RP+ V NT T P + + V F P+ AP
Sbjct: 744 RPIHHHVGKGPVFVKPKNTQPVAKSTHPPPLPAKEEPVEALTFSREHGPGVAEPEVATAP 803
Query: 272 SAILQPRQHPSKMLLLLPEAGRPALSPGHSPPSGAPG-PPAGVRTTRLPSPTPRLPTSSP 330
P K L E G+P LSPG S P P + T P P P +S
Sbjct: 804 PEKEIPSLDQEKTKL---EPGQPQLSPGISTIHLHPQFPGIVIEKTSPPVPVEVAPEAST 860
Query: 331 SAPVWLLSTLLATPVPTASLLGNLRPPSLLQGEVMGTP--------SSPRGPESPRLAAG 382
S+ +++ T + + + P G + P R E R
Sbjct: 861 SSASQVIAPTQVTEINECT----VNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVD 916
Query: 383 PSPCWHLGAM-HESRSRWTEPGCSQCWCEDGKVTCEK----------------------- 418
C + + + R TE G C C G + E+
Sbjct: 917 IDECTQVQHLCSQGRCENTE-GSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVN 975
Query: 419 ----VRCEAACSHPIPSRDGGCCPSCTGCFHSGVVRAEGDVFSPPNENCTVCV------- 467
RCE C G C C + E V SP + C C
Sbjct: 976 TVGAFRCE-YCDSGYRMTQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWN 1034
Query: 468 --CLAGNVSCISPE-CPSGPCQTPPQTDCCTCVPVRCYFHGRWYADGAVFSGGGDECTTC 524
CL + C+ P C +G C + C+C + G+ C
Sbjct: 1035 GQCLDVD-ECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNG 1093
Query: 525 VCQN--GEVECSFMPCPELACPREEWR----------LGPGQCCFTCQEPTPSTGCSLDD 572
C+N G C+ +L+ +++ GQ C+ S C D
Sbjct: 1094 QCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQ----CRNTEGSFQCVCDQ 1149
Query: 573 NGVEFPIGQIWSPGDPCE-LCICQADGSVSCKRTDCVD-------SCPHPIRI-PGQCCP 623
+ GD CE + C D SV C+R DC++ +CP ++ + C
Sbjct: 1150 G------YRASGLGDHCEDINECLEDKSV-CQRGDCINTAGSYDCTCPDGFQLDDNKTCQ 1202
Query: 624 DCSAGCTYTGRIFYNNETFPSVLDPCLSCICLLGSVACSPVDCPITCTYPF--HPDGECC 681
D N P + P C+ GS C C F DG C
Sbjct: 1203 D------------INECEHPGLCGPQGECLNTEGSFHC-------VCQQGFSISADGRTC 1243
Query: 682 PVCRDCNYEGRKVANGQVFTLDDEPCTRCTCQLGEVSCEKVPCQRACADP---ALLPGDC 738
+C V + F + RC C G + + + C D LL G C
Sbjct: 1244 EDIDEC--VNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQD---GQGCVDVNECELLSGVC 1298
Query: 739 ----CSSCPDSLSPL--EEKQGLSPHGNVAFSKAGRSLHGDTEAP 777
C + S + +E Q SP S+ L D + P
Sbjct: 1299 GEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQP 1343
Score = 32.7 bits (73), Expect = 1.7
Identities = 25/84 (29%), Positives = 38/84 (45%), Gaps = 12/84 (14%)
Query: 113 CNHGGCQEVARV----CPVGFSMTETAVGIRCTDIDECVT-----SSCEG-HCVNTEGGF 162
C +G C V C G+ + +TA + C D++EC S C+ C+NT+G +
Sbjct: 1632 CENGRCVRVQEGYTCDCFDGYHL-DTAK-MTCVDVNECDELNNRMSLCKNAKCINTDGSY 1689
Query: 163 VCECGPGMQLSADRHSCQDTDECL 186
C C PG S + C + L
Sbjct: 1690 KCLCLPGYVPSDKPNYCTPLNTAL 1713
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.478
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,247,279
Number of Sequences: 37866
Number of extensions: 3754283
Number of successful extensions: 37794
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 322
Number of HSP's successfully gapped in prelim test: 1382
Number of HSP's that attempted gapping in prelim test: 18770
Number of HSP's gapped (non-prelim): 12999
length of query: 955
length of database: 18,247,518
effective HSP length: 112
effective length of query: 843
effective length of database: 14,006,526
effective search space: 11807501418
effective search space used: 11807501418
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.