Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 22027651
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22027651 adaptor-related protein complex 1 beta 1 subunit
isoform a [Homo sapiens]
(949 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22027651 adaptor-related protein complex 1 beta 1 subunit iso... 1862 0.0
gi|22027653 adaptor-related protein complex 1 beta 1 subunit iso... 1839 0.0
gi|71773106 adaptor-related protein complex 2, beta 1 subunit is... 1569 0.0
gi|4557469 adaptor-related protein complex 2, beta 1 subunit iso... 1565 0.0
gi|166197671 adaptor-related protein complex 4, beta 1 subunit [... 296 6e-80
gi|34482047 adaptor-related protein complex 3, beta 2 subunit [H... 279 8e-75
gi|32484979 adaptor-related protein complex 3, beta 1 subunit [H... 276 5e-74
gi|27477041 adaptor-related protein complex 2, alpha 2 subunit [... 96 1e-19
gi|19913416 adaptor-related protein complex 2, alpha 1 subunit i... 96 1e-19
gi|19913414 adaptor-related protein complex 2, alpha 1 subunit i... 95 3e-19
gi|117553580 adaptor-related protein complex 3, delta 1 subunit ... 92 2e-18
gi|71772942 adaptor-related protein complex 1, gamma 1 subunit i... 92 2e-18
gi|71773010 adaptor-related protein complex 1, gamma 1 subunit i... 91 7e-18
gi|221316632 coatomer protein complex, subunit beta 1 [Homo sapi... 85 3e-16
gi|221316630 coatomer protein complex, subunit beta 1 [Homo sapi... 85 3e-16
gi|7705369 coatomer protein complex, subunit beta 1 [Homo sapiens] 85 3e-16
gi|11559929 coatomer protein complex, subunit gamma 1 [Homo sapi... 68 5e-11
gi|37675283 adaptor-related protein complex 4, epsilon 1 subunit... 67 8e-11
gi|109134349 coatomer protein complex, subunit gamma 2 [Homo sap... 67 1e-10
gi|4503843 adaptor-related protein complex 1, gamma 2 subunit [H... 58 5e-08
gi|117553584 adaptor-related protein complex 3, delta 1 subunit ... 52 3e-06
gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo sap... 37 0.067
gi|6912678 sperm associated antigen 6 isoform 1 [Homo sapiens] 37 0.11
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 36 0.15
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 36 0.19
gi|45356151 non-SMC condensin II complex, subunit D3 [Homo sapiens] 36 0.19
gi|20143482 melanoma antigen family E, 1 [Homo sapiens] 35 0.25
gi|7662236 TSC22 domain family, member 2 [Homo sapiens] 35 0.25
gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens] 35 0.33
gi|27262641 sperm associated antigen 6 isoform 2 [Homo sapiens] 35 0.33
>gi|22027651 adaptor-related protein complex 1 beta 1 subunit
isoform a [Homo sapiens]
Length = 949
Score = 1862 bits (4822), Expect = 0.0
Identities = 949/949 (100%), Positives = 949/949 (100%)
Query: 1 MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQT 60
MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQT
Sbjct: 1 MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQT 60
Query: 61 DNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITE 120
DNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITE
Sbjct: 61 DNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITE 120
Query: 121 YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANA 180
YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANA
Sbjct: 121 YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANA 180
Query: 181 VAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSI 240
VAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSI
Sbjct: 181 VAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSI 240
Query: 241 CERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDLDYYGTLLKKLAPPLVTLLSAEPELQY 300
CERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDLDYYGTLLKKLAPPLVTLLSAEPELQY
Sbjct: 241 CERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDLDYYGTLLKKLAPPLVTLLSAEPELQY 300
Query: 301 VALRNINLIVQKRPEILKHEMKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE 360
VALRNINLIVQKRPEILKHEMKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE
Sbjct: 301 VALRNINLIVQKRPEILKHEMKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE 360
Query: 361 YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRK 420
YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRK
Sbjct: 361 YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRK 420
Query: 421 YPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV 480
YPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV
Sbjct: 421 YPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV 480
Query: 481 QLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVAAKEV 540
QLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVAAKEV
Sbjct: 481 QLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVAAKEV 540
Query: 541 VLAEKPLISEETDLIEPTLLDELICYIGTLASVYHKPPSAFVEGGRGVVHKSLPPRTASS 600
VLAEKPLISEETDLIEPTLLDELICYIGTLASVYHKPPSAFVEGGRGVVHKSLPPRTASS
Sbjct: 541 VLAEKPLISEETDLIEPTLLDELICYIGTLASVYHKPPSAFVEGGRGVVHKSLPPRTASS 600
Query: 601 ESAESPETAPTGAPPGEQPDVIPAQGDLLGDLLNLDLGPPVSGPPLATSSVQMGAVDLLG 660
ESAESPETAPTGAPPGEQPDVIPAQGDLLGDLLNLDLGPPVSGPPLATSSVQMGAVDLLG
Sbjct: 601 ESAESPETAPTGAPPGEQPDVIPAQGDLLGDLLNLDLGPPVSGPPLATSSVQMGAVDLLG 660
Query: 661 GGLDSLMGDEPEGIGGTNFVAPPTAAVPANLGAPIGSGLSDLFDLTSGVGTLSGSYVAPK 720
GGLDSLMGDEPEGIGGTNFVAPPTAAVPANLGAPIGSGLSDLFDLTSGVGTLSGSYVAPK
Sbjct: 661 GGLDSLMGDEPEGIGGTNFVAPPTAAVPANLGAPIGSGLSDLFDLTSGVGTLSGSYVAPK 720
Query: 721 AVWLPAMKAKGLEISGTFTRQVGSISMDLQLTNKALQVMTDFAIQFNRNSFGLAPATPLQ 780
AVWLPAMKAKGLEISGTFTRQVGSISMDLQLTNKALQVMTDFAIQFNRNSFGLAPATPLQ
Sbjct: 721 AVWLPAMKAKGLEISGTFTRQVGSISMDLQLTNKALQVMTDFAIQFNRNSFGLAPATPLQ 780
Query: 781 VHAPLSPNQTVEISLPLSTVGSVMKMEPLNNLQVAVKNNIDVFYFSTLYPLHILFVEDGK 840
VHAPLSPNQTVEISLPLSTVGSVMKMEPLNNLQVAVKNNIDVFYFSTLYPLHILFVEDGK
Sbjct: 781 VHAPLSPNQTVEISLPLSTVGSVMKMEPLNNLQVAVKNNIDVFYFSTLYPLHILFVEDGK 840
Query: 841 MDRQMFLATWKDIPNENEAQFQIRDCPLNAEAASSKLQSSNIFTVAKRNVEGQDMLYQSL 900
MDRQMFLATWKDIPNENEAQFQIRDCPLNAEAASSKLQSSNIFTVAKRNVEGQDMLYQSL
Sbjct: 841 MDRQMFLATWKDIPNENEAQFQIRDCPLNAEAASSKLQSSNIFTVAKRNVEGQDMLYQSL 900
Query: 901 KLTNGIWVLAELRIQPGNPSCTDLELSLKCRAPEVSQHVYQAYETILKN 949
KLTNGIWVLAELRIQPGNPSCTDLELSLKCRAPEVSQHVYQAYETILKN
Sbjct: 901 KLTNGIWVLAELRIQPGNPSCTDLELSLKCRAPEVSQHVYQAYETILKN 949
>gi|22027653 adaptor-related protein complex 1 beta 1 subunit
isoform b [Homo sapiens]
Length = 942
Score = 1839 bits (4764), Expect = 0.0
Identities = 942/949 (99%), Positives = 942/949 (99%), Gaps = 7/949 (0%)
Query: 1 MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQT 60
MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQT
Sbjct: 1 MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQT 60
Query: 61 DNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITE 120
DNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITE
Sbjct: 61 DNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITE 120
Query: 121 YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANA 180
YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANA
Sbjct: 121 YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANA 180
Query: 181 VAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSI 240
VAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSI
Sbjct: 181 VAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSI 240
Query: 241 CERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDLDYYGTLLKKLAPPLVTLLSAEPELQY 300
CERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDLDYYGTLLKKLAPPLVTLLSAEPELQY
Sbjct: 241 CERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDLDYYGTLLKKLAPPLVTLLSAEPELQY 300
Query: 301 VALRNINLIVQKRPEILKHEMKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE 360
VALRNINLIVQKRPEILKHEMKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE
Sbjct: 301 VALRNINLIVQKRPEILKHEMKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE 360
Query: 361 YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRK 420
YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRK
Sbjct: 361 YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRK 420
Query: 421 YPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV 480
YPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV
Sbjct: 421 YPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV 480
Query: 481 QLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVAAKEV 540
QLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVAAKEV
Sbjct: 481 QLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVAAKEV 540
Query: 541 VLAEKPLISEETDLIEPTLLDELICYIGTLASVYHKPPSAFVEGGRGVVHKSLPPRTASS 600
VLAEKPLISEETDLIEPTLLDELICYIGTLASVYHKPPSAFVEGGRGVVHKSLPPRTASS
Sbjct: 541 VLAEKPLISEETDLIEPTLLDELICYIGTLASVYHKPPSAFVEGGRGVVHKSLPPRTASS 600
Query: 601 ESAESPETAPTGAPPGEQPDVIPAQGDLLGDLLNLDLGPPVSGPPLATSSVQMGAVDLLG 660
ESAESPETAPTGAPPGEQPDVIPAQGDLLGDLLNLDLGPPVSGPPLATSSVQMGAVDLLG
Sbjct: 601 ESAESPETAPTGAPPGEQPDVIPAQGDLLGDLLNLDLGPPVSGPPLATSSVQMGAVDLLG 660
Query: 661 GGLDSLMGDEPEGIGGTNFVAPPTAAVPANLGAPIGSGLSDLFDLTSGVGTLSGSYVAPK 720
GGLDSL IGGTNFVAPPTAAVPANLGAPIGSGLSDLFDLTSGVGTLSGSYVAPK
Sbjct: 661 GGLDSL-------IGGTNFVAPPTAAVPANLGAPIGSGLSDLFDLTSGVGTLSGSYVAPK 713
Query: 721 AVWLPAMKAKGLEISGTFTRQVGSISMDLQLTNKALQVMTDFAIQFNRNSFGLAPATPLQ 780
AVWLPAMKAKGLEISGTFTRQVGSISMDLQLTNKALQVMTDFAIQFNRNSFGLAPATPLQ
Sbjct: 714 AVWLPAMKAKGLEISGTFTRQVGSISMDLQLTNKALQVMTDFAIQFNRNSFGLAPATPLQ 773
Query: 781 VHAPLSPNQTVEISLPLSTVGSVMKMEPLNNLQVAVKNNIDVFYFSTLYPLHILFVEDGK 840
VHAPLSPNQTVEISLPLSTVGSVMKMEPLNNLQVAVKNNIDVFYFSTLYPLHILFVEDGK
Sbjct: 774 VHAPLSPNQTVEISLPLSTVGSVMKMEPLNNLQVAVKNNIDVFYFSTLYPLHILFVEDGK 833
Query: 841 MDRQMFLATWKDIPNENEAQFQIRDCPLNAEAASSKLQSSNIFTVAKRNVEGQDMLYQSL 900
MDRQMFLATWKDIPNENEAQFQIRDCPLNAEAASSKLQSSNIFTVAKRNVEGQDMLYQSL
Sbjct: 834 MDRQMFLATWKDIPNENEAQFQIRDCPLNAEAASSKLQSSNIFTVAKRNVEGQDMLYQSL 893
Query: 901 KLTNGIWVLAELRIQPGNPSCTDLELSLKCRAPEVSQHVYQAYETILKN 949
KLTNGIWVLAELRIQPGNPSCTDLELSLKCRAPEVSQHVYQAYETILKN
Sbjct: 894 KLTNGIWVLAELRIQPGNPSCTDLELSLKCRAPEVSQHVYQAYETILKN 942
>gi|71773106 adaptor-related protein complex 2, beta 1 subunit
isoform a [Homo sapiens]
Length = 951
Score = 1569 bits (4062), Expect = 0.0
Identities = 797/957 (83%), Positives = 874/957 (91%), Gaps = 14/957 (1%)
Query: 1 MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQT 60
MTDSKYFTT KKGEIFELKAELN++KKEK+KEAVKKVIA+MTVGKDVS+LFPDVVNCMQT
Sbjct: 1 MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQT 60
Query: 61 DNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITE 120
DNLELKKLVYLYLMNYAKSQPDMAIMAVN+FVKDCEDPNPLIRALAVRTMGCIRVDKITE
Sbjct: 61 DNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITE 120
Query: 121 YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANA 180
YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQ+VEDQGFLD+L+DLI+DSNPMVVANA
Sbjct: 121 YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANA 180
Query: 181 VAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSI 240
VAALSEI+ESHP+SNLLDLNPQ+INKLLTALNECTEWGQIFILDCL+NY PKDDREAQSI
Sbjct: 181 VAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSI 240
Query: 241 CERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDLDYYGTLLKKLAPPLVTLLSAEPELQY 300
CERVTPRLSHANSAVVLSAVKVLMKF+E+L KD DYY LLKKLAPPLVTLLS EPE+QY
Sbjct: 241 CERVTPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQY 300
Query: 301 VALRNINLIVQKRPEILKHEMKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE 360
VALRNINLIVQKRPEILK E+KVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE
Sbjct: 301 VALRNINLIVQKRPEILKQEIKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE 360
Query: 361 YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRK 420
YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVI+DIFRK
Sbjct: 361 YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRK 420
Query: 421 YPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV 480
YPNKYES+IATLCENLDSLDEP+ARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV
Sbjct: 421 YPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV 480
Query: 481 QLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVAAKEV 540
QL LLTAIVKLFLKKP+ETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPV AKEV
Sbjct: 481 QLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVTAKEV 540
Query: 541 VLAEKPLISEETDLIEPTLLDELICYIGTLASVYHKPPSAFVEGGRGVVHKSLPPRTASS 600
VL+EKPLISEETDLIEPTLLDELIC+IG+LASVYHKPP+AFVEG G+ K LP S+
Sbjct: 541 VLSEKPLISEETDLIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGST 600
Query: 601 ESAESPETAPTGAPPGEQPDVIPAQGDLLGDLLNLDLGPPVSGPPLATSSVQMGAVDLLG 660
++ +SP T A EQP VIP+QGDLLGDLLNLDLGPPV+ P + SS+QMGAVDLLG
Sbjct: 601 DAGDSP-VGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQV--SSMQMGAVDLLG 657
Query: 661 GGLDSLMG-DEPEGIGGTNFV-------APPTAAVPANLGAPIGSGLSDLFDLTSGVGTL 712
GGLDSL+G D GIGG+ V + P P+ A + SGL+DLF+L++G+G
Sbjct: 658 GGLDSLLGSDLGGGIGGSPAVGQSFIPSSVPATFAPSPTPAVVSSGLNDLFELSTGIGMA 717
Query: 713 SGSYVAPKAVWLPAMKAKGLEISGTFTRQVGSISMDLQLTNKALQVMTDFAIQFNRNSFG 772
G YVAPKAVWLPA+KAKGLEISGTFT + G I M++ TNKALQ MTDFAIQFN+NSFG
Sbjct: 718 PGGYVAPKAVWLPAVKAKGLEISGTFTHRQGHIYMEMNFTNKALQHMTDFAIQFNKNSFG 777
Query: 773 LAPATPLQVHAPLSPNQTVEISLPLSTVGSVMKMEPLNNLQVAVKNNIDVFYFSTLYPLH 832
+ P+TPL +H PL PNQ++++SLPL+T+G VMKMEPLNNLQVAVKNNIDVFYFS L PL+
Sbjct: 778 VIPSTPLAIHTPLMPNQSIDVSLPLNTLGPVMKMEPLNNLQVAVKNNIDVFYFSCLIPLN 837
Query: 833 ILFVEDGKMDRQMFLATWKDIPNENEAQFQIRDCPLNAEAASSKLQSSNIFTVAKRNVEG 892
+LFVEDGKM+RQ+FLATWKDIPNENE QFQI++C LNA+ SSKLQ++N++T+AKRNVEG
Sbjct: 838 VLFVEDGKMERQVFLATWKDIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEG 897
Query: 893 QDMLYQSLKLTNGIWVLAELRIQPGNPSCTDLELSLKCRAPEVSQHVYQAYETILKN 949
QDMLYQSLKLTNGIW+LAELRIQPGNP+ T LSLKCRAPEVSQ++YQ Y++ILKN
Sbjct: 898 QDMLYQSLKLTNGIWILAELRIQPGNPNYT---LSLKCRAPEVSQYIYQVYDSILKN 951
>gi|4557469 adaptor-related protein complex 2, beta 1 subunit
isoform b [Homo sapiens]
Length = 937
Score = 1565 bits (4053), Expect = 0.0
Identities = 795/951 (83%), Positives = 870/951 (91%), Gaps = 16/951 (1%)
Query: 1 MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQT 60
MTDSKYFTT KKGEIFELKAELN++KKEK+KEAVKKVIA+MTVGKDVS+LFPDVVNCMQT
Sbjct: 1 MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQT 60
Query: 61 DNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITE 120
DNLELKKLVYLYLMNYAKSQPDMAIMAVN+FVKDCEDPNPLIRALAVRTMGCIRVDKITE
Sbjct: 61 DNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITE 120
Query: 121 YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANA 180
YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQ+VEDQGFLD+L+DLI+DSNPMVVANA
Sbjct: 121 YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANA 180
Query: 181 VAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSI 240
VAALSEI+ESHP+SNLLDLNPQ+INKLLTALNECTEWGQIFILDCL+NY PKDDREAQSI
Sbjct: 181 VAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSI 240
Query: 241 CERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDLDYYGTLLKKLAPPLVTLLSAEPELQY 300
CERVTPRLSHANSAVVLSAVKVLMKF+E+L KD DYY LLKKLAPPLVTLLS EPE+QY
Sbjct: 241 CERVTPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQY 300
Query: 301 VALRNINLIVQKRPEILKHEMKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE 360
VALRNINLIVQKRPEILK E+KVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE
Sbjct: 301 VALRNINLIVQKRPEILKQEIKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE 360
Query: 361 YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRK 420
YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVI+DIFRK
Sbjct: 361 YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRK 420
Query: 421 YPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV 480
YPNKYES+IATLCENLDSLDEP+ARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV
Sbjct: 421 YPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV 480
Query: 481 QLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVAAKEV 540
QL LLTAIVKLFLKKP+ETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPV AKEV
Sbjct: 481 QLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVTAKEV 540
Query: 541 VLAEKPLISEETDLIEPTLLDELICYIGTLASVYHKPPSAFVEGGRGVVHKSLPPRTASS 600
VL+EKPLISEETDLIEPTLLDELIC+IG+LASVYHKPP+AFVEG G+ K LP S+
Sbjct: 541 VLSEKPLISEETDLIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGST 600
Query: 601 ESAESPETAPTGAPPGEQPDVIPAQGDLLGDLLNLDLGPPVSGPPLATSSVQMGAVDLLG 660
++ +SP T A EQP VIP+QGDLLGDLLNLDLGPPV+ P + SS+QMGAVDLLG
Sbjct: 601 DAGDSP-VGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQV--SSMQMGAVDLLG 657
Query: 661 GGLDSLMGDE--PEGIGGTNFVAPPTAAVPANLGAPIGSGLSDLFDLTSGVGTLSGSYVA 718
GGLDSL+G P + T F PT AV + SGL+DLF+L++G+G G YVA
Sbjct: 658 GGLDSLVGQSFIPSSVPAT-FAPSPTPAV-------VSSGLNDLFELSTGIGMAPGGYVA 709
Query: 719 PKAVWLPAMKAKGLEISGTFTRQVGSISMDLQLTNKALQVMTDFAIQFNRNSFGLAPATP 778
PKAVWLPA+KAKGLEISGTFT + G I M++ TNKALQ MTDFAIQFN+NSFG+ P+TP
Sbjct: 710 PKAVWLPAVKAKGLEISGTFTHRQGHIYMEMNFTNKALQHMTDFAIQFNKNSFGVIPSTP 769
Query: 779 LQVHAPLSPNQTVEISLPLSTVGSVMKMEPLNNLQVAVKNNIDVFYFSTLYPLHILFVED 838
L +H PL PNQ++++SLPL+T+G VMKMEPLNNLQVAVKNNIDVFYFS L PL++LFVED
Sbjct: 770 LAIHTPLMPNQSIDVSLPLNTLGPVMKMEPLNNLQVAVKNNIDVFYFSCLIPLNVLFVED 829
Query: 839 GKMDRQMFLATWKDIPNENEAQFQIRDCPLNAEAASSKLQSSNIFTVAKRNVEGQDMLYQ 898
GKM+RQ+FLATWKDIPNENE QFQI++C LNA+ SSKLQ++N++T+AKRNVEGQDMLYQ
Sbjct: 830 GKMERQVFLATWKDIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEGQDMLYQ 889
Query: 899 SLKLTNGIWVLAELRIQPGNPSCTDLELSLKCRAPEVSQHVYQAYETILKN 949
SLKLTNGIW+LAELRIQPGNP+ T LSLKCRAPEVSQ++YQ Y++ILKN
Sbjct: 890 SLKLTNGIWILAELRIQPGNPNYT---LSLKCRAPEVSQYIYQVYDSILKN 937
>gi|166197671 adaptor-related protein complex 4, beta 1 subunit
[Homo sapiens]
Length = 739
Score = 296 bits (758), Expect = 6e-80
Identities = 165/518 (31%), Positives = 293/518 (56%), Gaps = 13/518 (2%)
Query: 31 KEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNT 90
+ +++VI MT G D+S +F ++V T ++ KKLVYLY+ YA +PD+A++A+NT
Sbjct: 30 RNVIQRVIRYMTQGLDMSGVFMEMVKASATVDIVQKKLVYLYMCTYAPLKPDLALLAINT 89
Query: 91 FVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHD 150
KDC DPNP++R LA+R+M +R+ + EY+ +P+ L+D+ YVR+ A + AK+H+
Sbjct: 90 LCKDCSDPNPMVRGLALRSMCSLRMPGVQEYIQQPILNGLRDKASYVRRVAVLGCAKMHN 149
Query: 151 INAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAESHPSSNLLDLNPQSINKLLTA 210
++ D ++ L L+ D +P+VV N + +L EI + + +N + LL
Sbjct: 150 LHGDSEVDGALVNELYSLLRDQDPIVVVNCLRSLEEILKQEGG---VVINKPIAHHLLNR 206
Query: 211 LNECTEWGQIFILDCLANYMPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFMEML 270
+++ +WGQ +L+ L Y P+ + E I + L ++ VV+ A K+ + +L
Sbjct: 207 MSKLDQWGQAEVLNFLLRYQPRSEEELFDILNLLDSFLKSSSPGVVMGATKLFL----IL 262
Query: 271 SKDLDYYGT-LLKKLAPPLVTLLSAEP-ELQYVALRNINLIVQKRPEILKHEMKVFFVKY 328
+K + T +L ++ PL+ S+E EL +VAL ++ I+ P K FF Y
Sbjct: 263 AKMFPHVQTDVLVRVKGPLLAACSSESRELCFVALCHVRQILHSLPGHFSSHYKKFFCSY 322
Query: 329 NDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSA 388
++P Y+KL+K++++ L + N+ QVL EL+ Y T+V DF + A+ AIG A
Sbjct: 323 SEPHYIKLQKVEVLCELVNDENVQQVLEELRGYCTDVSADFAQAAIFAIGGIA---RTYT 379
Query: 389 ERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAM 448
++CV L +L+ + ++ + +D+ P E+V L +++ + E + A+
Sbjct: 380 DQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQCTEAVCQALPGCEENIQDSEGKQAL 439
Query: 449 IWIVGEYAERIDNADELLESFLEGFHDES-TQVQLQLLTAIVKLFLKKPTETQELVQQVL 507
IW++G + ERI NA +LE F+E E+ V+++LLTA+++LFL +P E Q+++ ++L
Sbjct: 440 IWLLGVHGERIPNAPYVLEDFVENVKSETFPAVKMELLTALLRLFLSRPAECQDMLGRLL 499
Query: 508 SLATQDSDNPDLRDRGYIYWRLLSTDPVAAKEVVLAEK 545
++ + +RDRG Y+RLL K ++ + K
Sbjct: 500 YYCIEEEKDMAVRDRGLFYYRLLLVGIDEVKRILCSPK 537
>gi|34482047 adaptor-related protein complex 3, beta 2 subunit [Homo
sapiens]
Length = 1082
Score = 279 bits (714), Expect = 8e-75
Identities = 184/613 (30%), Positives = 317/613 (51%), Gaps = 59/613 (9%)
Query: 17 ELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNY 76
+LK L+++K K EA+K+++A + GK+ S LFP VV + N+E+KKLVY+YL+ Y
Sbjct: 41 DLKEMLDTNKDSLKLEAMKRIVAMIARGKNASDLFPAVVKNVACKNIEVKKLVYVYLVRY 100
Query: 77 AKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPY 136
A+ Q D+A+++++TF + +DPN LIRA A+R + IRV I + +++ D PY
Sbjct: 101 AEEQQDLALLSISTFQRGLKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAASDMSPY 160
Query: 137 VRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAESHPSSNL 196
VRKTAA + KL+ +++ +DQ ++ ++ L++D +V + V A E+
Sbjct: 161 VRKTAAHAIPKLYSLDSDQ-KDQ-LIEVIEKLLADKTTLVAGSVVMAFEEVCPER----- 213
Query: 197 LDLNPQSINKLLTALNECTEWGQIFILDCLANYMP-----------------------KD 233
+DL ++ KL L + EWGQ+ I+ L Y +
Sbjct: 214 IDLIHKNYRKLCNLLIDVEEWGQVVIISMLTRYARTQFLSPTQNESLLEENAEKAFYGSE 273
Query: 234 DREAQSICERVT---------PRLSHANSAVVLSAVKVLMKFME--MLSKDLDYYGTLLK 282
+ EA+ T P + + ++L K L++ ++ Y L
Sbjct: 274 EDEAKGAGSEETAAAAAPSRKPYVMDPDHRLLLRNTKPLLQSRSAAVVMAVAQLYFHLAP 333
Query: 283 K-----LAPPLVTLLSAEPELQYVALRNINLIVQKRPEILKHEMKVFFVKYNDPIYVKLE 337
K +A LV LL + E+QYV L+N+ + KR + + +K F+++ DP +K+
Sbjct: 334 KAEVGVIAKALVRLLRSHSEVQYVVLQNVATMSIKRRGMFEPYLKSFYIRSTDPTQIKIL 393
Query: 338 KLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLD 397
KL+++ LA++ NI VL E + Y +D DFV ++AIGRCA + + + C++ L+
Sbjct: 394 KLEVLTNLANETNIPTVLREFQTYIRSMDKDFVAATIQAIGRCATNIGRVRDTCLNGLVQ 453
Query: 398 LIQTKVNYVVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAE 457
L+ + VV E++VVIK + + P ++ +I L + D++ P ARA+++W++GEY E
Sbjct: 454 LLSNRDELVVAESVVVIKKLLQMQPAQHGEIIKHLAKLTDNIQVPMARASILWLIGEYCE 513
Query: 458 RIDN-ADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDN 516
+ A ++L + F E V+LQ++ KL+L +T+ L Q VLSLA D N
Sbjct: 514 HVPRIAPDVLRKMAKSFTAEEDIVKLQVINLAAKLYLTNSKQTKLLTQYVLSLAKYD-QN 572
Query: 517 PDLRDRGYIYWRLLSTDPVA------AKEVVLAEKPLISEETDLIEPTLLDELICYIGTL 570
D+RDR +L+ AK++ LA KP ++E + D +G+L
Sbjct: 573 YDIRDRARFTRQLIVPSEQGGALSRHAKKLFLAPKP-----APVLESSFKDRDHFQLGSL 627
Query: 571 ASVYHKPPSAFVE 583
+ + + + + E
Sbjct: 628 SHLLNAKATGYQE 640
>gi|32484979 adaptor-related protein complex 3, beta 1 subunit [Homo
sapiens]
Length = 1094
Score = 276 bits (707), Expect = 5e-74
Identities = 178/609 (29%), Positives = 316/609 (51%), Gaps = 51/609 (8%)
Query: 11 KKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVY 70
KK E +LK L S+K K +A+K+++ + GK+ S LFP VV + + N+E+KKLVY
Sbjct: 42 KKNE--DLKQMLESNKDSAKLDAMKRIVGMIAKGKNASELFPAVVKNVASKNIEIKKLVY 99
Query: 71 LYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCL 130
+YL+ YA+ Q D+A+++++TF + +DPN LIRA A+R + IRV I + +++
Sbjct: 100 VYLVRYAEEQQDLALLSISTFQRALKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAS 159
Query: 131 KDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAES 190
D PYVRK AA + KL+ ++ + + + ++ ++ L+ D + +V + V A E+
Sbjct: 160 ADLSPYVRKNAAHAIQKLYSLDPE--QKEMLIEVIEKLLKDKSTLVAGSVVMAFEEVCPD 217
Query: 191 HPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLA----------------------N 228
+DL ++ KL L + EWGQ+ I+ L N
Sbjct: 218 R-----IDLIHKNYRKLCNLLVDVEEWGQVVIIHMLTRYARTQFVSPWKEGDELEDNGKN 272
Query: 229 YMPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFME--MLSKDLDYYGTLLKK--- 283
+ DD + + ++ P + +++ K L++ ++ Y + K
Sbjct: 273 FYESDDDQKEKTDKKKKPYTMDPDHRLLIRNTKPLLQSRNAAVVMAVAQLYWHISPKSEA 332
Query: 284 --LAPPLVTLLSAEPELQYVALRNINLIVQKRPEILKHEMKVFFVKYNDPIYVKLEKLDI 341
++ LV LL + E+QY+ L+NI + +R + + +K F+V+ DP +K KL+I
Sbjct: 333 GIISKSLVRLLRSNREVQYIVLQNIATMSIQRKGMFEPYLKSFYVRSTDPTMIKTLKLEI 392
Query: 342 MIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQT 401
+ LA++ANI+ +L E + Y D F ++ IGRCA + + + C++ L+ L+
Sbjct: 393 LTNLANEANISTLLREFQTYVKSQDKQFAAATIQTIGRCATNILEVTDTCLNGLVCLLSN 452
Query: 402 KVNYVVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERIDN 461
+ VV E++VVIK + + P ++ +I + + LDS+ P ARA+++W++GE ER+
Sbjct: 453 RDEIVVAESVVVIKKLLQMQPAQHGEIIKHMAKLLDSITVPVARASILWLIGENCERVPK 512
Query: 462 -ADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDNPDLR 520
A ++L + F E V+LQ+L KL+L +T+ L Q +L+L D N D+R
Sbjct: 513 IAPDVLRKMAKSFTSEDDLVKLQILNLGAKLYLTNSKQTKLLTQYILNLGKYD-QNYDIR 571
Query: 521 DRGYIYWRLLSTDPVA------AKEVVLAEKPLISEETDLIEPTLLDELICYIGTLASVY 574
DR +L+ + + AK++ LA+KP L+E D +GTL+
Sbjct: 572 DRTRFIRQLIVPNVKSGALSKYAKKIFLAQKP-----APLLESPFKDRDHFQLGTLSHTL 626
Query: 575 HKPPSAFVE 583
+ + ++E
Sbjct: 627 NIKATGYLE 635
>gi|27477041 adaptor-related protein complex 2, alpha 2 subunit
[Homo sapiens]
Length = 939
Score = 96.3 bits (238), Expect = 1e-19
Identities = 148/684 (21%), Positives = 275/684 (40%), Gaps = 96/684 (14%)
Query: 14 EIFELKAELNSDKK---EKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVY 70
E+ ++++ DK KK+ V K++ +G D+ + VN + ++ K++ Y
Sbjct: 36 ELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTEKQIGY 95
Query: 71 LYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCL 130
L++ S ++ + N D NP LA+ + + ++ E + K L
Sbjct: 96 LFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVL 155
Query: 131 KDEDPY--VRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIA 188
D V+++AA+C+ +L+ + LV + + L++D + VV A + ++ +A
Sbjct: 156 VAGDTMDSVKQSAALCLLRLYRTSPDLVPMGDWTSRVVHLLNDQHLGVVTAATSLITTLA 215
Query: 189 ESHPS--SNLLDLNPQSINKLLTA----LNECT------EWGQIFILDCLANYMPKDD-- 234
+ +P + L +++++T+ L + T W + +L L Y P D
Sbjct: 216 QKNPEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPPPDPAV 275
Query: 235 ------------REAQSICERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDLDYYGTLLK 282
+AQ + + S+A +AV+ A+ +++ D LL
Sbjct: 276 RGRLTECLETILNKAQEPPKSKKVQHSNAKNAVLFEAISLIIHH--------DSEPNLLV 327
Query: 283 KLAPPLVTLLS-AEPELQYVALRNINLIVQKR--PEILKHEMKVFF--VKYNDPIYVKLE 337
+ L L E L+Y+AL ++ + E +K ++ +K + V+
Sbjct: 328 RACNQLGQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIETVINALKTERDVSVRQR 387
Query: 338 KLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLD 397
+D++ + ++N Q++AE+ Y D + V + A K V T+L+
Sbjct: 388 AVDLLYAMCDRSNAPQIVAEMLSYLETADYSIREEIVLKVAILAEKYAVDYTWYVDTILN 447
Query: 398 LIQTKVNYVVQEA------IVVIKDIFRKYPNK--YESVIATLC-ENLDSLDEPEARAAM 448
LI+ +YV +E IV+ +D + Y K +E++ A C ENL +
Sbjct: 448 LIRIAGDYVSEEVWYRVIQIVINRDDVQGYAAKTVFEALQAPACHENLVKVGG------- 500
Query: 449 IWIVGEYAERI---DNADELLESFL--EGFHDESTQVQLQLLTAIVKLFLKKPTETQELV 503
+I+GE+ I + L++ L FH S + LL+ +K F+ E + +
Sbjct: 501 -YILGEFGNLIAGDPRSSPLIQFHLLHSKFHLCSVPTRALLLSTYIK-FVNLFPEVKPTI 558
Query: 504 QQVLSLATQ-DSDNPDLRDRGYIYWRLLSTDPVAAKEVVLAEKPLISEETDLIEPTLLDE 562
Q VL +Q + + +L+ R Y RL + VL E P E E ++L +
Sbjct: 559 QDVLRSDSQLRNADVELQQRAVEYLRLSTVASTDILATVLEEMPPFPER----ESSILAK 614
Query: 563 LICYIGTLASVYHKPPSAFVEGGRGVVHKSLPPRTASSESAESPETAPTGAPPGEQPDVI 622
L K PS + + + R+ P A T A P
Sbjct: 615 L---------KKKKGPSTVTD-----LEDTKRDRSVDVNGGPEPAPASTSAVSTPSPS-- 658
Query: 623 PAQGDLLGDLLNLDLGPPV-SGPP 645
DLL L PP +GPP
Sbjct: 659 -------ADLLGLGAAPPAPAGPP 675
>gi|19913416 adaptor-related protein complex 2, alpha 1 subunit
isoform 2 [Homo sapiens]
Length = 955
Score = 96.3 bits (238), Expect = 1e-19
Identities = 147/698 (21%), Positives = 280/698 (40%), Gaps = 75/698 (10%)
Query: 14 EIFELKAELNSDKK---EKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVY 70
E+ ++++ DK KK+ V K++ +G D+ + VN + ++ K++ Y
Sbjct: 36 ELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNKYTEKQIGY 95
Query: 71 LYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCL 130
L++ S ++ + N D NP LA+ + + ++ E + + L
Sbjct: 96 LFISVLVNSNSELIRLINNAIKNDLASRNPTFMCLALHCIANVGSREMGEAFAADIPRIL 155
Query: 131 --KDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIA 188
D V+++AA+C+ +L+ + LV + + L++D + VV AV+ ++ +
Sbjct: 156 VAGDSMDSVKQSAALCLLRLYKASPDLVPMGEWTARVVHLLNDQHMGVVTAAVSLITCLC 215
Query: 189 ESHPS--SNLLDLNPQSINKLL----TALNECT------EWGQIFILDCLANYMPKDD-- 234
+ +P + L +++++ T L + T W + +L L Y P +D
Sbjct: 216 KKNPDDFKTCVSLAVSRLSRIVSSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPPPEDAA 275
Query: 235 -------------REAQSICERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDLDYYGTLL 281
+AQ + + S+A +A++ + +++ + D LL
Sbjct: 276 VKGRLVECLETVLNKAQEPPKSKKVQHSNAKNAILFETISLIIHY--------DSEPNLL 327
Query: 282 KKLAPPLVTLLS-AEPELQYVALRNINLIVQKR--PEILKHEMKVFF--VKYNDPIYVKL 336
+ L L E L+Y+AL ++ + E +K + +K + V+
Sbjct: 328 VRACNQLGQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIDTVINALKTERDVSVRQ 387
Query: 337 EKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLL 396
D++ + ++N Q+++E+ Y D + V + A K V T+L
Sbjct: 388 RAADLLYAMCDRSNAKQIVSEMLRYLETADYAIREEIVLKVAILAEKYAVDYSWYVDTIL 447
Query: 397 DLIQTKVNYVVQEA------IVVIKDIFRKYPNK--YESVIATLC-ENLDSLDEPEARAA 447
+LI+ +YV +E IV +D + Y K +E++ A C EN+ +
Sbjct: 448 NLIRIAGDYVSEEVWYRVLQIVTNRDDVQGYAAKTVFEALQAPACHENMVKVGG------ 501
Query: 448 MIWIVGEYAERI----DNADELLESFLEG-FHDESTQVQLQLLTAIVKLFLKKPTETQEL 502
+I+GE+ I ++ + S L FH S + LL+ +K F+ ET+
Sbjct: 502 --YILGEFGNLIAGDPRSSPPVQFSLLHSKFHLCSVATRALLLSTYIK-FINLFPETKAT 558
Query: 503 VQQVLSLATQ-DSDNPDLRDRGYIYWRLLSTDPVAAKEVVLAEKPLISEETDLIEPTLLD 561
+Q VL +Q + + +L+ R Y L S VL E P E I L
Sbjct: 559 IQGVLRAGSQLRNADVELQQRAVEYLTLSSVASTDVLATVLEEMPPFPERESSILAKLKR 618
Query: 562 ELICYIGTLASVYHKPPSA-FVEGGRGVVHKSLPPRTASSESAESPETAPTGAPPGEQPD 620
+ G+ + PS+ + GG P T S+ S + APP P
Sbjct: 619 KKGPGAGSALDDGRRDPSSNDINGG-----MEPTPSTVSTPSPSADLLGLRAAPPPAAPP 673
Query: 621 VIPAQGDLLGDLLNLDLGPPVSGPPLATSSVQMGAVDL 658
G+LL D+ + P GP + + G D+
Sbjct: 674 ASAGAGNLLVDVFDGPAAQPSLGPTPEEAFLSPGPEDI 711
>gi|19913414 adaptor-related protein complex 2, alpha 1 subunit
isoform 1 [Homo sapiens]
Length = 977
Score = 95.1 bits (235), Expect = 3e-19
Identities = 145/684 (21%), Positives = 275/684 (40%), Gaps = 75/684 (10%)
Query: 14 EIFELKAELNSDKK---EKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVY 70
E+ ++++ DK KK+ V K++ +G D+ + VN + ++ K++ Y
Sbjct: 36 ELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNKYTEKQIGY 95
Query: 71 LYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCL 130
L++ S ++ + N D NP LA+ + + ++ E + + L
Sbjct: 96 LFISVLVNSNSELIRLINNAIKNDLASRNPTFMCLALHCIANVGSREMGEAFAADIPRIL 155
Query: 131 --KDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIA 188
D V+++AA+C+ +L+ + LV + + L++D + VV AV+ ++ +
Sbjct: 156 VAGDSMDSVKQSAALCLLRLYKASPDLVPMGEWTARVVHLLNDQHMGVVTAAVSLITCLC 215
Query: 189 ESHPS--SNLLDLNPQSINKLL----TALNECT------EWGQIFILDCLANYMPKDD-- 234
+ +P + L +++++ T L + T W + +L L Y P +D
Sbjct: 216 KKNPDDFKTCVSLAVSRLSRIVSSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPPPEDAA 275
Query: 235 -------------REAQSICERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDLDYYGTLL 281
+AQ + + S+A +A++ + +++ + D LL
Sbjct: 276 VKGRLVECLETVLNKAQEPPKSKKVQHSNAKNAILFETISLIIHY--------DSEPNLL 327
Query: 282 KKLAPPLVTLLS-AEPELQYVALRNINLIVQKR--PEILKHEMKVFF--VKYNDPIYVKL 336
+ L L E L+Y+AL ++ + E +K + +K + V+
Sbjct: 328 VRACNQLGQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIDTVINALKTERDVSVRQ 387
Query: 337 EKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLL 396
D++ + ++N Q+++E+ Y D + V + A K V T+L
Sbjct: 388 RAADLLYAMCDRSNAKQIVSEMLRYLETADYAIREEIVLKVAILAEKYAVDYSWYVDTIL 447
Query: 397 DLIQTKVNYVVQEA------IVVIKDIFRKYPNK--YESVIATLC-ENLDSLDEPEARAA 447
+LI+ +YV +E IV +D + Y K +E++ A C EN+ +
Sbjct: 448 NLIRIAGDYVSEEVWYRVLQIVTNRDDVQGYAAKTVFEALQAPACHENMVKVGG------ 501
Query: 448 MIWIVGEYAERI----DNADELLESFLEG-FHDESTQVQLQLLTAIVKLFLKKPTETQEL 502
+I+GE+ I ++ + S L FH S + LL+ +K F+ ET+
Sbjct: 502 --YILGEFGNLIAGDPRSSPPVQFSLLHSKFHLCSVATRALLLSTYIK-FINLFPETKAT 558
Query: 503 VQQVLSLATQ-DSDNPDLRDRGYIYWRLLSTDPVAAKEVVLAEKPLISEETDLIEPTLLD 561
+Q VL +Q + + +L+ R Y L S VL E P E I L
Sbjct: 559 IQGVLRAGSQLRNADVELQQRAVEYLTLSSVASTDVLATVLEEMPPFPERESSILAKLKR 618
Query: 562 ELICYIGTLASVYHKPPSA-FVEGGRGVVHKSLPPRTASSESAESPETAPTGAPPGEQPD 620
+ G+ + PS+ + GG P T S+ S + APP P
Sbjct: 619 KKGPGAGSALDDGRRDPSSNDINGG-----MEPTPSTVSTPSPSADLLGLRAAPPPAAPP 673
Query: 621 VIPAQGDLLGDLLNLDLGPPVSGP 644
G+LL D+ + P GP
Sbjct: 674 ASAGAGNLLVDVFDGPAAQPSLGP 697
>gi|117553580 adaptor-related protein complex 3, delta 1 subunit
isoform 2 [Homo sapiens]
Length = 1153
Score = 92.4 bits (228), Expect = 2e-18
Identities = 100/476 (21%), Positives = 198/476 (41%), Gaps = 28/476 (5%)
Query: 15 IFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLM 74
I E+K EL D K AV K+ +G D+S +++ M K++ YL
Sbjct: 40 IDEIKQELKQDNIAVKANAVCKLTYLQMLGYDISWAAFNIIEVMSASKFTFKRIGYLAAS 99
Query: 75 NYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDED 134
D+ ++ N KD P+ +A+ + C + L + +
Sbjct: 100 QSFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLMSHTK 159
Query: 135 PYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAESHPSS 194
PY+RK A + + K+ + + LK+ + D +P V + AV + E+A +P
Sbjct: 160 PYIRKKAVLIMYKVFLKYPESLRPA--FPRLKEKLEDPDPGVQSAAVNVICELARRNP-K 216
Query: 195 NLLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSICERVTPRLSHANSA 254
N L L P + ++ N W I I+ P + R + + E +T L H+ SA
Sbjct: 217 NYLSLAPLFFKLMTSSTN---NWVLIKIIKLFGALTPLEPRLGKKLIEPLT-NLIHSTSA 272
Query: 255 VVL--SAVKVLMKFMEMLSKDLDYYGTLLKKLAPPLVTLL-SAEPELQYVALRNINLIVQ 311
+ L V ++ + LS + + ++ L L+ ++ L+Y+ L ++ I++
Sbjct: 273 MSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKILK 332
Query: 312 KRPE-ILKHEMKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAEL-----KEYATEV 365
P+ + H+ + + ++L LD++ + S+ N+ +++ +L K T
Sbjct: 333 THPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEGTTY 392
Query: 366 DVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQ---TKVNYVVQ----EAIVVIKDIF 418
+ + K + + + + E +S L++L + T+ +++ + + +K I
Sbjct: 393 RDELLTKIIDICSQSNYQYITNFEWYISILVELTRLEGTRHGHLIAAQMLDVAIRVKAI- 451
Query: 419 RKYPNKYESVIATLCENLDSLDEP----EARAAMIWIVGEYAERIDNADELLESFL 470
RK+ S + L S + E A WI GE++E + LE+ L
Sbjct: 452 RKFAVSQMSALLDSAHLLASSTQRNGICEVLYAAAWICGEFSEHLQEPHHTLEAML 507
>gi|71772942 adaptor-related protein complex 1, gamma 1 subunit
isoform b [Homo sapiens]
Length = 822
Score = 92.4 bits (228), Expect = 2e-18
Identities = 180/805 (22%), Positives = 323/805 (40%), Gaps = 132/805 (16%)
Query: 66 KKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEP 125
K++ YL M + D+ ++ N D ++ LA+ T+GC+ ++ L
Sbjct: 82 KRIGYLGAMLLLDERQDVHLLMTNCIKNDLNHSTQFVQGLALCTLGCMGSSEMCRDLAGE 141
Query: 126 LRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALS 185
+ K LK + Y+RK AA+C + +L+E FL K+L+++ N V+ +V L+
Sbjct: 142 VEKLLKTSNSYLRKKAALCAVHVIRKVPELME--MFLPATKNLLNEKNHGVLHTSVVLLT 199
Query: 186 EIAESHPS--SNLLDLNPQSINKLLTALNE-----------CTEWGQIFILDCLANYMPK 232
E+ E P ++ L PQ + L + + Q+ IL L
Sbjct: 200 EMCERSPDMLAHFRKLVPQLVRILKNLIMSGYSPEHDVSGISDPFLQVRILRLLRILGRN 259
Query: 233 DDREAQS---ICERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDLDYYGTLLKKLAPPLV 289
DD +++ I +V + + + ++ M++ S+ + L+ LA ++
Sbjct: 260 DDDSSEAMNDILAQVATNTETSKNVGNAILYETVLTIMDIKSE------SGLRVLAINIL 313
Query: 290 --TLLSAEPELQYVALRNINLIVQ-KRPEILKHEMKVFFVKYNDPIYVKLEKLDIMIRLA 346
LL+ + ++YVAL ++ VQ + +H + + + +K +++ L
Sbjct: 314 GRFLLNNDKNIRYVALTSLLKTVQTDHNAVQRHRSTIVDCLKDLDVSIKRRAMELSFALV 373
Query: 347 SQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYV 406
+ NI ++ EL + + +F I A K S + T++ ++ T +YV
Sbjct: 374 NGNNIRGMMKELLYFLDSCEPEFKADCASGIFLAAEKYAPSKRWHIDTIMRVLTTAGSYV 433
Query: 407 VQEAIVVIKDIFRKYPNKYESVIATLCENL--DSLDEPEARAAMIWIVGEYAERI----- 459
+A+ + + + + L + + D +P + A W +GEY + +
Sbjct: 434 RDDAVPNLIQLITNSVEMHAYTVQRLYKAILGDYSQQPLVQVA-AWCIGEYGDLLVSGQC 492
Query: 460 ----------DNADELLESFLEGFHDESTQV-QLQLLTAIVKLFLKKPTETQELVQQVLS 508
D ++LES L + ST V + LTAI+KL + T T +++V+S
Sbjct: 493 EEEEPIQVTEDEVLDILESVL--ISNMSTSVTRGYALTAIMKLSTRF-TCTVNRIKKVVS 549
Query: 509 LATQDSDNPDLRDRGYIYWRLLSTDPVAAKEVVLAEKPLISEETDLIEPTLLDELICYIG 568
+ D +L+ R Y L ++ D + LL+ +
Sbjct: 550 IYGSSID-VELQQRAVEYNALF-------------------KKYDHMRSALLERM----P 585
Query: 569 TLASVYHKPPSAFVEGGRGVVHKSLPPRTASSESAESP-ETAPTGAPPGEQPDVIPAQGD 627
+ V P+ V+ + E+ +P ET P P G QP D
Sbjct: 586 VMEKVTTNGPTEIVQ--------------TNGETEPAPLETKP--PPSGPQP--TSQAND 627
Query: 628 LLGDLLNLDLGPPVSGPPLATSSVQMGAVDLLGGGLDSLMGDEPEGIGGTNFVAPPTAAV 687
LL L D+ P + P A +S A GG L L+GD + G AP A+V
Sbjct: 628 LLDLLGGNDITPVI---PTAPTSKPSSA----GGELLDLLGD--INLTGAPAAAPAPASV 678
Query: 688 PANLGAPI---GSGLSDLF-DLTSGVGTLSGSYVAPKAVWLPAMKAKGLEISGTFTRQVG 743
P P G LF D+ +G+ +++ A GL+I TF R
Sbjct: 679 PQISQPPFLLDGLSSQPLFNDIAAGIPSIT------------AYSKNGLKIEFTFERSNT 726
Query: 744 SIS---MDLQLTNKALQVMTDFAIQFNRNSFGLAPAT-PLQVHAPLSPNQTVEISLPLST 799
+ S + +Q +N MTDF Q P T LQ+ LSP+ ++ + T
Sbjct: 727 NPSVTVITIQASNSTELDMTDFVFQ------AAVPKTFQLQL---LSPSSSIVPAFNTGT 777
Query: 800 VGSVMKMEPLNNLQVAVKNNIDVFY 824
+ V+K+ LN + ++ I + Y
Sbjct: 778 ITQVIKV--LNPQKQQLRMRIKLTY 800
>gi|71773010 adaptor-related protein complex 1, gamma 1 subunit
isoform a [Homo sapiens]
Length = 825
Score = 90.5 bits (223), Expect = 7e-18
Identities = 180/808 (22%), Positives = 322/808 (39%), Gaps = 135/808 (16%)
Query: 66 KKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEP 125
K++ YL M + D+ ++ N D ++ LA+ T+GC+ ++ L
Sbjct: 82 KRIGYLGAMLLLDERQDVHLLMTNCIKNDLNHSTQFVQGLALCTLGCMGSSEMCRDLAGE 141
Query: 126 LRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALS 185
+ K LK + Y+RK AA+C + +L+E FL K+L+++ N V+ +V L+
Sbjct: 142 VEKLLKTSNSYLRKKAALCAVHVIRKVPELME--MFLPATKNLLNEKNHGVLHTSVVLLT 199
Query: 186 EIAESHPSSNL-LDLNPQSINKLLTALNECTEWG---------------QIFILDCLANY 229
E+ E P N + + +L+ L G Q+ IL L
Sbjct: 200 EMCERSPDMLAHFRKNEKLVPQLVRILKNLIMSGYSPEHDVSGISDPFLQVRILRLLRIL 259
Query: 230 MPKDDREAQS---ICERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDLDYYGTLLKKLAP 286
DD +++ I +V + + + ++ M++ S+ + L+ LA
Sbjct: 260 GRNDDDSSEAMNDILAQVATNTETSKNVGNAILYETVLTIMDIKSE------SGLRVLAI 313
Query: 287 PLV--TLLSAEPELQYVALRNINLIVQ-KRPEILKHEMKVFFVKYNDPIYVKLEKLDIMI 343
++ LL+ + ++YVAL ++ VQ + +H + + + +K +++
Sbjct: 314 NILGRFLLNNDKNIRYVALTSLLKTVQTDHNAVQRHRSTIVDCLKDLDVSIKRRAMELSF 373
Query: 344 RLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKV 403
L + NI ++ EL + + +F I A K S + T++ ++ T
Sbjct: 374 ALVNGNNIRGMMKELLYFLDSCEPEFKADCASGIFLAAEKYAPSKRWHIDTIMRVLTTAG 433
Query: 404 NYVVQEAIVVIKDIFRKYPNKYESVIATLCENL--DSLDEPEARAAMIWIVGEYAERI-- 459
+YV +A+ + + + + L + + D +P + A W +GEY + +
Sbjct: 434 SYVRDDAVPNLIQLITNSVEMHAYTVQRLYKAILGDYSQQPLVQVA-AWCIGEYGDLLVS 492
Query: 460 -------------DNADELLESFLEGFHDESTQV-QLQLLTAIVKLFLKKPTETQELVQQ 505
D ++LES L + ST V + LTAI+KL + T T +++
Sbjct: 493 GQCEEEEPIQVTEDEVLDILESVL--ISNMSTSVTRGYALTAIMKLSTRF-TCTVNRIKK 549
Query: 506 VLSLATQDSDNPDLRDRGYIYWRLLSTDPVAAKEVVLAEKPLISEETDLIEPTLLDELIC 565
V+S+ D +L+ R Y L ++ D + LL+ +
Sbjct: 550 VVSIYGSSID-VELQQRAVEYNALF-------------------KKYDHMRSALLERM-- 587
Query: 566 YIGTLASVYHKPPSAFVEGGRGVVHKSLPPRTASSESAESP-ETAPTGAPPGEQPDVIPA 624
+ V P+ V+ + E+ +P ET P P G QP
Sbjct: 588 --PVMEKVTTNGPTEIVQ--------------TNGETEPAPLETKP--PPSGPQP--TSQ 627
Query: 625 QGDLLGDLLNLDLGPPVSGPPLATSSVQMGAVDLLGGGLDSLMGDEPEGIGGTNFVAPPT 684
DLL L D+ P + P A +S A GG L L+GD + G AP
Sbjct: 628 ANDLLDLLGGNDITPVI---PTAPTSKPSSA----GGELLDLLGD--INLTGAPAAAPAP 678
Query: 685 AAVPANLGAPI---GSGLSDLF-DLTSGVGTLSGSYVAPKAVWLPAMKAKGLEISGTFTR 740
A+VP P G LF D+ +G+ +++ A GL+I TF R
Sbjct: 679 ASVPQISQPPFLLDGLSSQPLFNDIAAGIPSIT------------AYSKNGLKIEFTFER 726
Query: 741 QVGSIS---MDLQLTNKALQVMTDFAIQFNRNSFGLAPAT-PLQVHAPLSPNQTVEISLP 796
+ S + +Q +N MTDF Q P T LQ+ LSP+ ++ +
Sbjct: 727 SNTNPSVTVITIQASNSTELDMTDFVFQ------AAVPKTFQLQL---LSPSSSIVPAFN 777
Query: 797 LSTVGSVMKMEPLNNLQVAVKNNIDVFY 824
T+ V+K+ LN + ++ I + Y
Sbjct: 778 TGTITQVIKV--LNPQKQQLRMRIKLTY 803
>gi|221316632 coatomer protein complex, subunit beta 1 [Homo
sapiens]
Length = 953
Score = 85.1 bits (209), Expect = 3e-16
Identities = 120/620 (19%), Positives = 250/620 (40%), Gaps = 101/620 (16%)
Query: 18 LKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVN-CMQTDNLELKKLVYLYLMNY 76
LK +L + K EA+KKVI + G+ + L ++ + + +KKL+ ++
Sbjct: 26 LKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLMTIIRFVLPLQDHTIKKLLLVFWEIV 85
Query: 77 AKSQPD-----MAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLK 131
K+ PD I+ + + KD + PN IR +R + ++ ++ E L +R CL+
Sbjct: 86 PKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLE 145
Query: 132 DEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKD-LISDSNPMVVANAVAALSEIAES 190
YVR+ A + + ++ L+ D + + D L+++ + NA L +
Sbjct: 146 HRHSYVRRNAVLAIYTIYRNFEHLIPDAP--ELIHDFLVNEKDASCKRNAFMMLIHADQD 203
Query: 191 HPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSICERVTPRLSH 250
++++ L T +++ +G I Q + + ++ H
Sbjct: 204 -----------RALDYLSTCIDQVQTFGDIL----------------QLVIVELIYKVCH 236
Query: 251 ANSAVVLSAVKVLMKFMEMLSKDLDYYGTLLKKLAPPLVTLLSAEPELQYVALRNINLIV 310
AN + ++ + ++ S + Y + A LVTL SA ++ A I+LI+
Sbjct: 237 ANPSERARFIRCIYNLLQSSSPAVKY------EAAGTLVTLSSAPTAIKAAAQCYIDLII 290
Query: 311 QKRPEILK---------------HE-------MKVFFVKYNDPIYVKLEKLDIMIRLASQ 348
++ +K HE M + V + V+ + L + + L S
Sbjct: 291 KESDNNVKLIVLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSS 350
Query: 349 ANIAQVLAELKEYATEV-------DVDFVRK-AVRAIGRCAIKVEQSAERCVSTLLDLIQ 400
N+ +++ LK+ + D D R+ VR + C+++ A + L++ +
Sbjct: 351 RNVEELVIVLKKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLS 410
Query: 401 TKVNYVVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERID 460
+ + +++ +++ N ++ + E ++ + +WI+GEY +
Sbjct: 411 DNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYCSTKE 470
Query: 461 NADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTE------TQELVQQVLSLATQ-- 512
+ ++ E V+ ++ +L KP E Q+LV ++ + ATQ
Sbjct: 471 DIQSVMTEIRRSL-GEIPIVESEIKKEAGEL---KPEEEITVGPVQKLVTEMGTYATQSA 526
Query: 513 ---------DSDNPDLR----DRGYIYWRLLST--DPVAAKEVVLAEKPLISEETDLIEP 557
+ D P LR D + L+T +A + V L ++ + + + E
Sbjct: 527 LSSSRPTKKEEDRPPLRGFLLDGDFFVAASLATTLTKIALRYVALVQEKK-KQNSFVAEA 585
Query: 558 TLLDELICYIGTLASVYHKP 577
LL I ++G +S+ KP
Sbjct: 586 MLLMATILHLGK-SSLPKKP 604
>gi|221316630 coatomer protein complex, subunit beta 1 [Homo
sapiens]
Length = 953
Score = 85.1 bits (209), Expect = 3e-16
Identities = 120/620 (19%), Positives = 250/620 (40%), Gaps = 101/620 (16%)
Query: 18 LKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVN-CMQTDNLELKKLVYLYLMNY 76
LK +L + K EA+KKVI + G+ + L ++ + + +KKL+ ++
Sbjct: 26 LKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLMTIIRFVLPLQDHTIKKLLLVFWEIV 85
Query: 77 AKSQPD-----MAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLK 131
K+ PD I+ + + KD + PN IR +R + ++ ++ E L +R CL+
Sbjct: 86 PKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLE 145
Query: 132 DEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKD-LISDSNPMVVANAVAALSEIAES 190
YVR+ A + + ++ L+ D + + D L+++ + NA L +
Sbjct: 146 HRHSYVRRNAVLAIYTIYRNFEHLIPDAP--ELIHDFLVNEKDASCKRNAFMMLIHADQD 203
Query: 191 HPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSICERVTPRLSH 250
++++ L T +++ +G I Q + + ++ H
Sbjct: 204 -----------RALDYLSTCIDQVQTFGDIL----------------QLVIVELIYKVCH 236
Query: 251 ANSAVVLSAVKVLMKFMEMLSKDLDYYGTLLKKLAPPLVTLLSAEPELQYVALRNINLIV 310
AN + ++ + ++ S + Y + A LVTL SA ++ A I+LI+
Sbjct: 237 ANPSERARFIRCIYNLLQSSSPAVKY------EAAGTLVTLSSAPTAIKAAAQCYIDLII 290
Query: 311 QKRPEILK---------------HE-------MKVFFVKYNDPIYVKLEKLDIMIRLASQ 348
++ +K HE M + V + V+ + L + + L S
Sbjct: 291 KESDNNVKLIVLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSS 350
Query: 349 ANIAQVLAELKEYATEV-------DVDFVRK-AVRAIGRCAIKVEQSAERCVSTLLDLIQ 400
N+ +++ LK+ + D D R+ VR + C+++ A + L++ +
Sbjct: 351 RNVEELVIVLKKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLS 410
Query: 401 TKVNYVVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERID 460
+ + +++ +++ N ++ + E ++ + +WI+GEY +
Sbjct: 411 DNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYCSTKE 470
Query: 461 NADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTE------TQELVQQVLSLATQ-- 512
+ ++ E V+ ++ +L KP E Q+LV ++ + ATQ
Sbjct: 471 DIQSVMTEIRRSL-GEIPIVESEIKKEAGEL---KPEEEITVGPVQKLVTEMGTYATQSA 526
Query: 513 ---------DSDNPDLR----DRGYIYWRLLST--DPVAAKEVVLAEKPLISEETDLIEP 557
+ D P LR D + L+T +A + V L ++ + + + E
Sbjct: 527 LSSSRPTKKEEDRPPLRGFLLDGDFFVAASLATTLTKIALRYVALVQEKK-KQNSFVAEA 585
Query: 558 TLLDELICYIGTLASVYHKP 577
LL I ++G +S+ KP
Sbjct: 586 MLLMATILHLGK-SSLPKKP 604
>gi|7705369 coatomer protein complex, subunit beta 1 [Homo sapiens]
Length = 953
Score = 85.1 bits (209), Expect = 3e-16
Identities = 120/620 (19%), Positives = 250/620 (40%), Gaps = 101/620 (16%)
Query: 18 LKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVN-CMQTDNLELKKLVYLYLMNY 76
LK +L + K EA+KKVI + G+ + L ++ + + +KKL+ ++
Sbjct: 26 LKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLMTIIRFVLPLQDHTIKKLLLVFWEIV 85
Query: 77 AKSQPD-----MAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLK 131
K+ PD I+ + + KD + PN IR +R + ++ ++ E L +R CL+
Sbjct: 86 PKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLE 145
Query: 132 DEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKD-LISDSNPMVVANAVAALSEIAES 190
YVR+ A + + ++ L+ D + + D L+++ + NA L +
Sbjct: 146 HRHSYVRRNAVLAIYTIYRNFEHLIPDAP--ELIHDFLVNEKDASCKRNAFMMLIHADQD 203
Query: 191 HPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSICERVTPRLSH 250
++++ L T +++ +G I Q + + ++ H
Sbjct: 204 -----------RALDYLSTCIDQVQTFGDIL----------------QLVIVELIYKVCH 236
Query: 251 ANSAVVLSAVKVLMKFMEMLSKDLDYYGTLLKKLAPPLVTLLSAEPELQYVALRNINLIV 310
AN + ++ + ++ S + Y + A LVTL SA ++ A I+LI+
Sbjct: 237 ANPSERARFIRCIYNLLQSSSPAVKY------EAAGTLVTLSSAPTAIKAAAQCYIDLII 290
Query: 311 QKRPEILK---------------HE-------MKVFFVKYNDPIYVKLEKLDIMIRLASQ 348
++ +K HE M + V + V+ + L + + L S
Sbjct: 291 KESDNNVKLIVLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSS 350
Query: 349 ANIAQVLAELKEYATEV-------DVDFVRK-AVRAIGRCAIKVEQSAERCVSTLLDLIQ 400
N+ +++ LK+ + D D R+ VR + C+++ A + L++ +
Sbjct: 351 RNVEELVIVLKKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLS 410
Query: 401 TKVNYVVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERID 460
+ + +++ +++ N ++ + E ++ + +WI+GEY +
Sbjct: 411 DNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYCSTKE 470
Query: 461 NADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTE------TQELVQQVLSLATQ-- 512
+ ++ E V+ ++ +L KP E Q+LV ++ + ATQ
Sbjct: 471 DIQSVMTEIRRSL-GEIPIVESEIKKEAGEL---KPEEEITVGPVQKLVTEMGTYATQSA 526
Query: 513 ---------DSDNPDLR----DRGYIYWRLLST--DPVAAKEVVLAEKPLISEETDLIEP 557
+ D P LR D + L+T +A + V L ++ + + + E
Sbjct: 527 LSSSRPTKKEEDRPPLRGFLLDGDFFVAASLATTLTKIALRYVALVQEKK-KQNSFVAEA 585
Query: 558 TLLDELICYIGTLASVYHKP 577
LL I ++G +S+ KP
Sbjct: 586 MLLMATILHLGK-SSLPKKP 604
>gi|11559929 coatomer protein complex, subunit gamma 1 [Homo
sapiens]
Length = 874
Score = 67.8 bits (164), Expect = 5e-11
Identities = 104/605 (17%), Positives = 242/605 (40%), Gaps = 75/605 (12%)
Query: 46 DVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRAL 105
+ + F + Q+++ L+++ YL + + D+ I+ ++ KD R
Sbjct: 65 EATEAFFAMTKLFQSNDPTLRRMCYLTIKEMSCIAEDV-IIVTSSLTKDMTGKEDNYRGP 123
Query: 106 AVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTL 165
AVR + I + + + +++ + D+ P V +A V + LH + + +++
Sbjct: 124 AVRALCQITDSTMLQAIERYMKQAIVDKVPSVSSSALV--SSLHLLKCSFDVVKRWVNEA 181
Query: 166 KDLISDSNPMVVANAVAALSEIAESHPSSNLLDLNPQSINKLLTALNEC---TEWGQIFI 222
++ S N MV +A+ L + ++ + ++NK+++ + + + +
Sbjct: 182 QEAASSDNIMVQYHALGLLYHVRKN---------DRLAVNKMISKVTRHGLKSPFAYCMM 232
Query: 223 LDCLANYMPKDDREAQS-ICERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDLDYYGTLL 281
+ + + ++D S + + + L + + VV A ++ G
Sbjct: 233 IRVASKQLEEEDGSRDSPLFDFIESCLRNKHEMVVYEAASAIVNLP----------GCSA 282
Query: 282 KKLAPPLVTLL----SAEPELQYVALRNINLIVQKRPE-ILKHEMKVFFVKYNDPIYVKL 336
K+LAP + L S + L+Y A+R +N + K P + + + + + +
Sbjct: 283 KELAPAVSVLQLFCSSPKAALRYAAVRTLNKVAMKHPSAVTACNLDLENLVTDSNRSIAT 342
Query: 337 EKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLL 396
+ +++ S+++I +++ ++ + +E+ +F V+AI K + ++ L
Sbjct: 343 LAITTLLKTGSESSIDRLMKQISSFMSEISDEFKVVVVQAISALCQKYPRKHAVLMNFLF 402
Query: 397 DLIQTKVNYVVQEAIV-VIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEY 455
+++ + + + AIV I I + E+ ++ LCE ++ + ++ ++G+
Sbjct: 403 TMLREEGGFEYKRAIVDCIISIIEENSESKETGLSHLCEFIEDCEFTVLATRILHLLGQE 462
Query: 456 AERIDNADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQELVQQVLSL---ATQ 512
+ N + + E +V+ ++A+ K + +E++ +L L
Sbjct: 463 GPKTTNPSKYIRFIYNRVVLEHEEVRAGAVSALAKF----GAQNEEMLPSILVLLKRCVM 518
Query: 513 DSDNPDLRDRGYIYWRLL----------------------------------STDPVAAK 538
D DN ++RDR Y +L S P K
Sbjct: 519 DDDN-EVRDRATFYLNVLEQKQKALNAGYILNGLTVSIPGLERALQQYTLEPSEKPFDLK 577
Query: 539 EVVLAEKPLISEETDLIEPTLLDELICYIGTLASVYHKPPSAFVE-GGRGVVHKSLPPRT 597
V LA P+ + T+ T + + T ++ + +A E G G + KS P
Sbjct: 578 SVPLATAPMAEQRTESTPITAVKQPEKVAATRQEIFQEQLAAVPEFRGLGPLFKSSPEPV 637
Query: 598 ASSES 602
A +ES
Sbjct: 638 ALTES 642
>gi|37675283 adaptor-related protein complex 4, epsilon 1 subunit
[Homo sapiens]
Length = 1137
Score = 67.0 bits (162), Expect = 8e-11
Identities = 108/472 (22%), Positives = 195/472 (41%), Gaps = 55/472 (11%)
Query: 14 EIFELKAELNSDKKEKK--KEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYL 71
E+ LKA +++ K KE + ++I +G D S + + Q NL K++ YL
Sbjct: 59 ELSSLKATVSAPTTTLKMMKECMVRLIYCEMLGYDASFGYIHAIKLAQQGNLLEKRVGYL 118
Query: 72 YLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLK 131
+ + ++ ++ VNT VKD + N + +A+ + I ++ + + L+
Sbjct: 119 AVSLFLHESHELLLLLVNTVVKDLQSTNLVEVCMALTVVSQIFPCEMIPAVLPLIEDKLQ 178
Query: 132 DEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAESH 191
VR+ A + + K H I V+ + K L ++ A+ L I E+
Sbjct: 179 HSKEIVRRKAVLALYKFHLIAPNQVQ-HIHIKFRKALCDRDVGVMAASLHIYLRMIKEN- 236
Query: 192 PSSNLLDLNPQSI--------NKLLTALNECT---EWGQIFILDCLANYMPKDDREAQSI 240
SS DL + KL N + W QI +L L + KDD+ +
Sbjct: 237 -SSGYKDLTGSFVTILKQVVGGKLPVEFNYHSVPAPWLQIQLLRIL-GLLGKDDQRTSEL 294
Query: 241 CERV------TPRLSH-ANSAVVLSAVKVLMKF---MEMLSKDLDYYGTLLKKLAPPLVT 290
V L+H A++ V + E+L K G
Sbjct: 295 MYDVLDESLRRAELNHNVTYAILFECVHTVYSIYPKSELLEKAAKCIGKF---------- 344
Query: 291 LLSAEPELQYVALRNINLIVQKRPEI-LKHEMKVF-FVKYNDPIYVKLEKLDIMIRLASQ 348
+LS + L+Y+ L+ + ++Q+ P + L+H+M + + + DPI +K E L+++ R+ +
Sbjct: 345 VLSPKINLKYLGLKALTYVIQQDPTLALQHQMTIIECLDHPDPI-IKRETLELLYRITNA 403
Query: 349 ANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQ 408
NI ++ ++ EY + ++V V +G K+ + AE+ IQT
Sbjct: 404 QNITVIVQKMLEYLHQSKEEYV--IVNLVG----KIAELAEKYAPDNAWFIQTMNAVFSV 457
Query: 409 EAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERID 460
V+ DI PN + + L E D DE E + ++ V Y +D
Sbjct: 458 GGDVMHPDI----PNNF---LRLLAEGFD--DETEDQQLRLYAVQSYLTLLD 500
>gi|109134349 coatomer protein complex, subunit gamma 2 [Homo
sapiens]
Length = 871
Score = 66.6 bits (161), Expect = 1e-10
Identities = 86/500 (17%), Positives = 213/500 (42%), Gaps = 32/500 (6%)
Query: 46 DVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRAL 105
+ + F + Q+++ L+++ YL + A D+ I+ ++ KD + R
Sbjct: 65 EATEAFFAMTRLFQSNDQTLRRMCYLTIKEMATISEDV-IIVTSSLTKDMTGKEDVYRGP 123
Query: 106 AVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTL 165
A+R + I + + + +++ + D+ V +A V + I+ +V+ +++
Sbjct: 124 AIRALCRITDGTMLQAIERYMKQAIVDKVSSVSSSALVSSLHMMKISYDVVKR--WINEA 181
Query: 166 KDLISDSNPMVVANAVAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDC 225
++ S N MV +A+ L + ++ + LN + + L + C +L
Sbjct: 182 QEAASSDNIMVQYHALGVLYHLRKNDRLAVSKMLNKFTKSGLKSQFAYC-------MLIR 234
Query: 226 LANYMPKD--DREAQSICERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDLDYYGTLLKK 283
+A+ + K+ D + + + L + + V+ A ++ +++L ++L+
Sbjct: 235 IASRLLKETEDGHESPLFDFIESCLRNKHEMVIYEAASAIIHLPNCTARELAPAVSVLQL 294
Query: 284 LAPPLVTLLSAEPELQYVALRNINLIVQKRPEIL---KHEMKVFFVKYNDPIYVKLEKLD 340
S +P L+Y A+R +N + K P + +++ N I +
Sbjct: 295 FCS------SPKPALRYAAVRTLNKVAMKHPSAVTACNLDLENLITDSNRSIATL--AIT 346
Query: 341 IMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQ 400
+++ S++++ +++ ++ + +E+ +F V+AI K + ++ L ++++
Sbjct: 347 TLLKTGSESSVDRLMKQISSFVSEISDEFKVVVVQAISALCQKYPRKHSVMMTFLSNMLR 406
Query: 401 TKVNYVVQEAIV-VIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERI 459
+ + AIV I I + P E+ +A LCE ++ + ++ ++G+ R
Sbjct: 407 DDGGFEYKRAIVDCIISIVEENPESKEAGLAHLCEFIEDCEHTVLATKILHLLGKEGPRT 466
Query: 460 DNADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQELVQQVLSL---ATQDSDN 516
+ + E+ V+ ++A+ K + + L+ +L L D+D+
Sbjct: 467 PVPSKYIRFIFNRVVLENEAVRAAAVSALAKF----GAQNESLLPSILVLLQRCMMDTDD 522
Query: 517 PDLRDRGYIYWRLLSTDPVA 536
++RDR Y +L +A
Sbjct: 523 -EVRDRATFYLNVLQQRQMA 541
>gi|4503843 adaptor-related protein complex 1, gamma 2 subunit [Homo
sapiens]
Length = 785
Score = 57.8 bits (138), Expect = 5e-08
Identities = 93/495 (18%), Positives = 195/495 (39%), Gaps = 45/495 (9%)
Query: 66 KKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEP 125
K++ YL M + D ++ N+ D ++ LA+ T+ + ++ L
Sbjct: 83 KRVGYLGAMLLLDERHDAHLLITNSIKNDLSQGIQPVQGLALCTLSTMGSAEMCRDLAPE 142
Query: 126 LRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALS 185
+ K L PYVRK A + +H I FL L+ + + ++ + ++
Sbjct: 143 VEKLLLQPSPYVRKKA--ILTAVHMIRKVPELSSVFLPPCAQLLHERHHGILLGTITLIT 200
Query: 186 EIAESHPSS--NLLDLNPQSIN--KLLTALNECTEWG---------QIFILDCLANYMPK 232
E+ E P++ + + PQ ++ + L + TE Q+ IL L
Sbjct: 201 ELCERSPAALRHFRKVVPQLVHILRTLVTMGYSTEHSISGVSDPFLQVQILRLLRILGRN 260
Query: 233 DDREAQSICERV------TPRLSHANSAVVLSAVKVLMKFMEMLSKDLDYYGTLLKKLAP 286
+ ++++ + + T +A +AV+ V +M L+ LA
Sbjct: 261 HEESSETMNDLLAQVATNTDTSRNAGNAVLFETVLTIMDIRSAAG---------LRVLAV 311
Query: 287 PLV--TLLSAEPELQYVALRNINLIVQK-RPEILKHEMKVFFVKYNDPIYVKLEKLDIMI 343
++ LL+++ ++YVAL ++ +VQ + +H V + L++ +
Sbjct: 312 NILGRFLLNSDRNIRYVALTSLLRLVQSDHSAVQRHRPTVVECLRETDASLSRRALELSL 371
Query: 344 RLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKV 403
L + +N+ ++ EL+ + D I A + + + T+L ++ T
Sbjct: 372 ALVNSSNVRAMMQELQAFLESCPPDLRADCASGILLAAERFAPTKRWHIDTILHVLTTAG 431
Query: 404 NYVVQEAIVVIKDIFRKYPNKYESVIATLCENL--DSLDEPEARAAMIWIVGEYAERI-- 459
+V +A+ + + + + L L D +P + A W +GEY + +
Sbjct: 432 THVRDDAVANLTQLIGGAQELHAYSVRRLYNALAEDISQQPLVQVA-AWCIGEYGDLLLA 490
Query: 460 DNADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQELVQQVLSLATQ-DSDNPD 518
N +E +E + +V L LL +++ + P + ++ L+T+ DN
Sbjct: 491 GNCEE-----IEPLQVDEEEV-LALLEKVLQSHMSLPATRGYALTALMKLSTRLCGDNNR 544
Query: 519 LRDRGYIYWRLLSTD 533
+R IY L +
Sbjct: 545 IRQVVSIYGSCLDVE 559
>gi|117553584 adaptor-related protein complex 3, delta 1 subunit
isoform 1 [Homo sapiens]
Length = 1112
Score = 51.6 bits (122), Expect = 3e-06
Identities = 58/268 (21%), Positives = 101/268 (37%), Gaps = 39/268 (14%)
Query: 15 IFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLM 74
I E+K EL D K AV K+ +G D+S +++ M K++ YL
Sbjct: 40 IDEIKQELKQDNIAVKANAVCKLTYLQMLGYDISWAAFNIIEVMSASKFTFKRIGYLAAS 99
Query: 75 NYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDED 134
D+ ++ N KD P+ +A+ + C + L + +
Sbjct: 100 QSFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLMSHTK 159
Query: 135 PYVRKTA---------------------------AVCVAKLHDINAQLVEDQGFLDTLKD 167
PY+RK A AV ++ + Q + L+
Sbjct: 160 PYIRKKAKLIEPLTNLIHSTSAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRI 219
Query: 168 LISDSNPMVVANAVAALSEIAESHPSSNLLDLNPQSINKL-LTALNECTEWGQIFILDCL 226
LI DS+ + + A+S+I ++HP S QS L L L++ E ++ LD L
Sbjct: 220 LIEDSDQNLKYLGLLAMSKILKTHPKS------VQSHKDLILQCLDDKDESIRLRALDLL 273
Query: 227 ANYMPKDDREAQSICERVTPRLSHANSA 254
+ K +++ E V ++H + A
Sbjct: 274 YGMVSK-----KNLMEIVKKLMTHVDKA 296
Score = 36.2 bits (82), Expect = 0.15
Identities = 50/256 (19%), Positives = 111/256 (43%), Gaps = 22/256 (8%)
Query: 235 REAQSICERVTPRLSHANSAVVL--SAVKVLMKFMEMLSKDLDYYGTLLKKLAPPLVTLL 292
R+ + E +T L H+ SA+ L V ++ + LS + + ++ L L+
Sbjct: 163 RKKAKLIEPLT-NLIHSTSAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILI 221
Query: 293 S-AEPELQYVALRNINLIVQKRPEILKHEMKVFFVKYNDPIY-VKLEKLDIMIRLASQAN 350
++ L+Y+ L ++ I++ P+ ++ + +D ++L LD++ + S+ N
Sbjct: 222 EDSDQNLKYLGLLAMSKILKTHPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKN 281
Query: 351 IAQVLAEL-----KEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQ---TK 402
+ +++ +L K T + + K + + + + E +S L++L + T+
Sbjct: 282 LMEIVKKLMTHVDKAEGTTYRDELLTKIIDICSQSNYQYITNFEWYISILVELTRLEGTR 341
Query: 403 VNYVVQ----EAIVVIKDIFRKYPNKYESVIATLCENLDSLDEP----EARAAMIWIVGE 454
+++ + + +K I RK+ S + L S + E A WI GE
Sbjct: 342 HGHLIAAQMLDVAIRVKAI-RKFAVSQMSALLDSAHLLASSTQRNGICEVLYAAAWICGE 400
Query: 455 YAERIDNADELLESFL 470
++E + LE+ L
Sbjct: 401 FSEHLQEPHHTLEAML 416
>gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo sapiens]
Length = 2161
Score = 37.4 bits (85), Expect = 0.067
Identities = 35/116 (30%), Positives = 45/116 (38%), Gaps = 14/116 (12%)
Query: 578 PSAFVEGGRGVVHKSLPPRTASSESAESPETAPTGAPPGEQPDVIPAQGDLLGDLLNLDL 637
PS VE G + + LPP S S E PE+ T PP PD PA L
Sbjct: 1552 PSVDVEDGEFLFVEPLPPPLEFSNSFEKPESPLTPGPPHPLPDT-PAPATPL-------- 1602
Query: 638 GPPVSGPPLATSSVQMGAVDLLGGGLDSLMGDEPEGI----GGTNFVAPPTAAVPA 689
PPV P +A + + + DS + +G G + PP A PA
Sbjct: 1603 -PPVPPPAVAAAPPTLDSTASSLTSYDSEVATLTQGASAAPGDPHPPGPPAPAAPA 1657
Score = 31.2 bits (69), Expect = 4.8
Identities = 44/198 (22%), Positives = 69/198 (34%), Gaps = 36/198 (18%)
Query: 577 PPSAFVEGGRGVVHKSLPPRTASSESAESPETAPTGAPPGEQPDVIPA-----QGDLLGD 631
PP+A V GG V +PP + S+ + P PG P +P Q L
Sbjct: 1806 PPTAGVAGGPVAVEPEVPPVPLPTASSLPRKLLPWEEGPGPPPPPLPGPLAQPQASALAT 1865
Query: 632 LLNLDLGPPVSGPPLATSSVQMGAVDLLGGGLDSLMGDEPEG----IGGTNFVAPPTAAV 687
+ + L++ Q G GG L G G GG ++V T+++
Sbjct: 1866 VKASIIS------ELSSKLQQFGGSSAAGGALPWARGGSGGGGDSHHGGASYVPERTSSL 1919
Query: 688 PAN----------LGAPIGSGLSD-----LFDLTSGVGTLSGSYVAPKAVWLPAMKAKGL 732
L P+ S + L L +G G V+P A P +
Sbjct: 1920 QRQRLSDDSQSSLLSKPVSSLFQNWPKPPLPPLPTGTG------VSPTAAAAPGATSPSA 1973
Query: 733 EISGTFTRQVGSISMDLQ 750
S T TR + + +++
Sbjct: 1974 SSSSTSTRHLQGVEFEMR 1991
>gi|6912678 sperm associated antigen 6 isoform 1 [Homo sapiens]
Length = 509
Score = 36.6 bits (83), Expect = 0.11
Identities = 61/289 (21%), Positives = 115/289 (39%), Gaps = 31/289 (10%)
Query: 52 PDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNTFV----------KDCEDPNPL 101
P +V C+Q + LK++ L + AK P++A V+ D + + +
Sbjct: 170 PLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQI 229
Query: 102 IRALAVRTMGCIRV-DKITEYLCEPL-RKCLKDEDPYVRKTAAVC---VAKLHDINAQLV 156
+ AL+ + + + + + E P+ CLKD+D YV+K A+ +AK +QLV
Sbjct: 230 LSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLV 289
Query: 157 EDQGFLDTLKDLISDSNPMVVANAVAALSEIAESHPSSNLLDLNPQSINKLLTALNECTE 216
+ G + + D I + L +A + + + + + +L L+E E
Sbjct: 290 VNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPE 349
Query: 217 WGQIFILDCLANYMPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFMEML--SKDL 274
+++ A R TP HA + V + + VL+ S+DL
Sbjct: 350 -----------DHIKAAAAWALGQIGRHTP--EHARAVAVTNTLPVLLSLYMSTESSEDL 396
Query: 275 DYYG-TLLKKLAPPLVTLLSAEPELQYVALRNINLIVQKRPEILKHEMK 322
+K + L + EP L + +V + ++L H+ K
Sbjct: 397 QVKSKKAIKNILQKCTYLPALEPFLYDAPPNILKHVVGQFSKVLPHDSK 445
Score = 32.3 bits (72), Expect = 2.2
Identities = 52/218 (23%), Positives = 95/218 (43%), Gaps = 50/218 (22%)
Query: 129 CLKDEDPYVRKTAAVCVAKLHDINAQL---VEDQGFLDTLKDLISDSNPMVVANAVAALS 185
CL+D DP V++ AA + + NA+L V D G + L I + + A +ALS
Sbjct: 133 CLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALS 192
Query: 186 EIAESHP--SSNLLD-----------LNPQS--INKLLTALNECTEW----------GQI 220
+IA+ P + ++D LNP + +++L+AL++ ++ +I
Sbjct: 193 DIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEI 252
Query: 221 F--ILDCLANYMPKDDREAQSICERV---TPRLSH--ANSAVVLSAVK------------ 261
F +L CL + + A ++ + TP LS N+ V + +
Sbjct: 253 FPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNTRLP 312
Query: 262 --VLMKFMEMLSKDLDYYGTLLKKLAPPLVTLLSAEPE 297
+++ ++ S++L ++ K P L LS EPE
Sbjct: 313 GIMMLGYVAAHSENL-AMAVIISKGVPQLSVCLSEEPE 349
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 36.2 bits (82), Expect = 0.15
Identities = 61/287 (21%), Positives = 123/287 (42%), Gaps = 41/287 (14%)
Query: 255 VVLSAVKVLMKFMEMLSKDLDYYGTLLKKLAPPLVTLLSAEPELQYVALRNINLIVQKRP 314
VV+ K+L + E L +DL ++KL ++ L A EL + ++Q
Sbjct: 1271 VVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELS-----EKSGMLQAEK 1325
Query: 315 EILKHEMKVFFVK-------YNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEV-- 365
++L+ ++K + + DP + KL + + I Q+ E+ E+
Sbjct: 1326 KLLEEDVKRWKARNQHLVSQQKDPDTEEYRKL-LSEKEVHTKRIQQLTEEIGRLKAEIAR 1384
Query: 366 -------DVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIF 418
+ + ++ + + + E + + ++D IQ KV + Q +K I
Sbjct: 1385 SNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIID-IQEKVKTITQ-----VKKIG 1438
Query: 419 RKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERIDNADEL--LESFLEGFHDE 476
R+Y +YE + A D + E A+++ G++ E+ + E+ L+ L +
Sbjct: 1439 RRYKTQYEELKA----QQDKVMETSAQSS-----GDHQEQHVSVQEMQELKETLNQAETK 1489
Query: 477 STQVQLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSD-NPDLRDR 522
S ++ Q + + K +K TE + L +Q + L ++ S DL+DR
Sbjct: 1490 SKSLESQ-VENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDR 1535
>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
sapiens]
Length = 5537
Score = 35.8 bits (81), Expect = 0.19
Identities = 45/174 (25%), Positives = 59/174 (33%), Gaps = 27/174 (15%)
Query: 567 IGTLASVYHKPPSAFVEG--GRGVVHKSLPPRTASSESAESP-------------ETAPT 611
+ T A + KPP+ V G G + LPP+ + ++ P TAP
Sbjct: 2135 LSTSADGFLKPPAGSVPGPDSPGELFLKLPPQVPAQVPSQDPFGLAPAYPLEPRFPTAPP 2194
Query: 612 GAPPGEQPDVIPAQGDLLGDLLNLDLGPP------VSGPPLATSSVQMGAVDLLGGGLDS 665
PP P PAQ +LG G P G P S + LD+
Sbjct: 2195 TYPPYPSPTGAPAQPPMLGASSRPGAGQPGEFHTTPPGTPRHQPSTPDPFLKPRCPSLDN 2254
Query: 666 LMGDEPEGIGGTNFVAPPTAAVPANLGAPIGSGLSDLFDLTSGVGTLSGSYVAP 719
L E G+GG A+ P P G L +G S SY P
Sbjct: 2255 LAVPESPGVGGGK------ASEPLLSPPPFGESRKALEVKKEELGASSPSYGPP 2302
>gi|45356151 non-SMC condensin II complex, subunit D3 [Homo sapiens]
Length = 1498
Score = 35.8 bits (81), Expect = 0.19
Identities = 69/320 (21%), Positives = 125/320 (39%), Gaps = 53/320 (16%)
Query: 82 DMAIMAVNTFVKD---CEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVR 138
D+A ++ V++ CED + V CIR + + + CLKD DP++R
Sbjct: 936 DLAKKSIPALVRELEVCEDVAVRNNVIIVMCDLCIRYTIMVDKYIPNISMCLKDSDPFIR 995
Query: 139 KTAAVCVAKLHDINAQLVEDQG--FLDTLKDLISDSNPMVVANAVAALSEIA-------- 188
K + + L + + V+ +G F + LI DS+P + + L+ +
Sbjct: 996 KQTLILLTNL--LQEEFVKWKGSLFFRFVSTLI-DSHPDIASFGEFCLAHLLLKRNPVMF 1052
Query: 189 --------------ESHPSSNLLDLNPQS--INKLLTALNECTEWGQIFILDCLANYMPK 232
E H N PQS +L + + + ++ I L +
Sbjct: 1053 FQHFIECIFHFNNYEKHEKYNKF---PQSEREKRLFSLKGKSNKERRMKIYKFLLEHFTD 1109
Query: 233 DDR--EAQSICERVTPRLSHANSAVVLSAVKVLMKFMEML-SKDLDYYGTLLKKLAPPLV 289
+ R IC + + + L A ++L E+L SK++ LL + P
Sbjct: 1110 EQRFNITSKICLSILACFADGILPLDLDASELLSDTFEVLSSKEI----KLLAMRSKPDK 1165
Query: 290 TLLSAEPELQYVALRNINLIVQKRPEILKHEMKVFFVKYNDPIYVKLEKLDIMIRLASQA 349
LL E ++ AL N+ ++ + + +++ K F++ PI + L + +
Sbjct: 1166 DLLMEEDDM---ALANV-VMQEAQKKLISQVQKRNFIENIIPIIISL-------KTVLEK 1214
Query: 350 NIAQVLAELKEYATEVDVDF 369
N L EL Y EV D+
Sbjct: 1215 NKIPALRELMHYLREVMQDY 1234
>gi|20143482 melanoma antigen family E, 1 [Homo sapiens]
Length = 957
Score = 35.4 bits (80), Expect = 0.25
Identities = 34/115 (29%), Positives = 43/115 (37%), Gaps = 16/115 (13%)
Query: 592 SLPPRTASSESAESPETAPTG------APPGEQPD--VIPAQGDLLGDLLNL----DLGP 639
S+PP S P T G A PGE P V+PA D G ++L G
Sbjct: 235 SVPPTATEGLSTPVPPTRDEGPSTSVPATPGEGPSTSVLPAASD--GQSISLVPTRGKGS 292
Query: 640 PVSGPPLATSSVQMGAVDLLGGGLDSLMGDEPEGIGGTNFVAPPTAAVPANLGAP 694
S PP AT + G G + + P GG + PPTA + P
Sbjct: 293 STSVPPTATEGLSTSVQPTAGEGSSTSVPPTPG--GGLSTSVPPTATEELSTSVP 345
>gi|7662236 TSC22 domain family, member 2 [Homo sapiens]
Length = 780
Score = 35.4 bits (80), Expect = 0.25
Identities = 28/104 (26%), Positives = 43/104 (41%), Gaps = 22/104 (21%)
Query: 591 KSLPPRTASSESAESPETAPTGAPPGEQPDVIPAQGDLLGDLLNLDLGPPVSGPPLATSS 650
+++ PRT ++ + PTG PP +G ++ LGP +G P +
Sbjct: 435 EAMAPRTGPAQGGQVAPCQPTGVPPA-----------TVGGVVQPCLGPAGAGQPQSVPP 483
Query: 651 VQMGAVDLLGGGLDSLMGDEPEGIGGTNFVAPPTAAVPANLGAP 694
QMG G L ++ GG + V P VPA + AP
Sbjct: 484 PQMGG----SGPLSAVP-------GGPHAVVPGVPNVPAAVPAP 516
>gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens]
Length = 707
Score = 35.0 bits (79), Expect = 0.33
Identities = 23/67 (34%), Positives = 29/67 (43%), Gaps = 9/67 (13%)
Query: 594 PPRTASSESAESPETAPTGAP---PGEQPDVIPAQGDLLGDLLNLDLGPPVSGPPLATSS 650
PP T + + P PTG P P E+P P G GPP +GP AT +
Sbjct: 453 PPTTTTPQPTAPPTVCPTGPPTVHPSERPTAGPTGPPSAG-----PTGPPTAGPSTAT-T 506
Query: 651 VQMGAVD 657
V + VD
Sbjct: 507 VPLSPVD 513
>gi|27262641 sperm associated antigen 6 isoform 2 [Homo sapiens]
Length = 458
Score = 35.0 bits (79), Expect = 0.33
Identities = 39/177 (22%), Positives = 76/177 (42%), Gaps = 15/177 (8%)
Query: 52 PDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNTFV----------KDCEDPNPL 101
P +V C+Q + LK++ L + AK P++A V+ D + + +
Sbjct: 170 PLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQI 229
Query: 102 IRALAVRTMGCIRV-DKITEYLCEPL-RKCLKDEDPYVRKTAAVC---VAKLHDINAQLV 156
+ AL+ + + + + + E P+ CLKD+D YV+K A+ +AK +QLV
Sbjct: 230 LSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLV 289
Query: 157 EDQGFLDTLKDLISDSNPMVVANAVAALSEIAESHPSSNLLDLNPQSINKLLTALNE 213
+ G + + D I + L +A + + + + + +L L+E
Sbjct: 290 VNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSE 346
Score = 32.3 bits (72), Expect = 2.2
Identities = 52/218 (23%), Positives = 95/218 (43%), Gaps = 50/218 (22%)
Query: 129 CLKDEDPYVRKTAAVCVAKLHDINAQL---VEDQGFLDTLKDLISDSNPMVVANAVAALS 185
CL+D DP V++ AA + + NA+L V D G + L I + + A +ALS
Sbjct: 133 CLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALS 192
Query: 186 EIAESHP--SSNLLD-----------LNPQS--INKLLTALNECTEW----------GQI 220
+IA+ P + ++D LNP + +++L+AL++ ++ +I
Sbjct: 193 DIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEI 252
Query: 221 F--ILDCLANYMPKDDREAQSICERV---TPRLSH--ANSAVVLSAVK------------ 261
F +L CL + + A ++ + TP LS N+ V + +
Sbjct: 253 FPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNTRLP 312
Query: 262 --VLMKFMEMLSKDLDYYGTLLKKLAPPLVTLLSAEPE 297
+++ ++ S++L ++ K P L LS EPE
Sbjct: 313 GIMMLGYVAAHSENL-AMAVIISKGVPQLSVCLSEEPE 349
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.380
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,278,847
Number of Sequences: 37866
Number of extensions: 1587350
Number of successful extensions: 6288
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 20
Number of HSP's successfully gapped in prelim test: 76
Number of HSP's that attempted gapping in prelim test: 6115
Number of HSP's gapped (non-prelim): 203
length of query: 949
length of database: 18,247,518
effective HSP length: 112
effective length of query: 837
effective length of database: 14,006,526
effective search space: 11723462262
effective search space used: 11723462262
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.