Search of human proteins with 22027648

Search of human proteins with 22027648

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|22027648 lipin 1 [Homo sapiens]
         (890 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|22027648 lipin 1 [Homo sapiens]                                   1798   0.0  
gi|7662022 lipin 2 [Homo sapiens]                                     867   0.0  
gi|74271888 lipin 3 [Homo sapiens]                                    748   0.0  
gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2...    44   7e-04
gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1...    44   7e-04
gi|132626688 mediator of DNA-damage checkpoint 1 [Homo sapiens]        41   0.006
gi|155722990 solute carrier family 4 (anion exchanger), member 1...    41   0.006
gi|56550039 myeloid/lymphoid or mixed-lineage leukemia protein [...    40   0.010
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                         40   0.013
gi|21361272 myeloid/lymphoid or mixed-lineage leukemia (trithora...    39   0.016
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   39   0.016
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   39   0.016
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   39   0.016
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    39   0.016
gi|38788333 remodeling and spacing factor 1 [Homo sapiens]             39   0.021
gi|117553580 adaptor-related protein complex 3, delta 1 subunit ...    39   0.021
gi|169213985 PREDICTED: similar to hCG2036794 [Homo sapiens]           39   0.021
gi|239751846 PREDICTED: similar to hCG2036794 [Homo sapiens]           39   0.021
gi|239746337 PREDICTED: similar to hCG2036794 [Homo sapiens]           39   0.021
gi|150378543 MYST histone acetyltransferase (monocytic leukemia)...    38   0.037
gi|150378463 MYST histone acetyltransferase (monocytic leukemia)...    38   0.037
gi|150378493 MYST histone acetyltransferase (monocytic leukemia)...    38   0.037
gi|117553584 adaptor-related protein complex 3, delta 1 subunit ...    38   0.048
gi|102467235 inner centromere protein antigens 135/155kDa isofor...    38   0.048
gi|102467242 inner centromere protein antigens 135/155kDa isofor...    38   0.048
gi|7662238 apoptotic chromatin condensation inducer 1 [Homo sapi...    37   0.062
gi|162287219 prune homolog 2 [Homo sapiens]                            37   0.082
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]    37   0.082
gi|197313748 SET domain containing 2 [Homo sapiens]                    36   0.14 
gi|224549005 RNA binding motif protein 17 [Homo sapiens]               36   0.18 

>gi|22027648 lipin 1 [Homo sapiens]
          Length = 890

 Score = 1798 bits (4657), Expect = 0.0
 Identities = 890/890 (100%), Positives = 890/890 (100%)

Query: 1   MNYVGQLAGQVFVTVKELYKGLNPATLSGCIDIIVIRQPNGNLQCSPFHVRFGKMGVLRS 60
           MNYVGQLAGQVFVTVKELYKGLNPATLSGCIDIIVIRQPNGNLQCSPFHVRFGKMGVLRS
Sbjct: 1   MNYVGQLAGQVFVTVKELYKGLNPATLSGCIDIIVIRQPNGNLQCSPFHVRFGKMGVLRS 60

Query: 61  REKVVDIEINGESVDLHMKLGDNGEAFFVQETDNDQEVIPMHLATSPILSEGASRMECQL 120
           REKVVDIEINGESVDLHMKLGDNGEAFFVQETDNDQEVIPMHLATSPILSEGASRMECQL
Sbjct: 61  REKVVDIEINGESVDLHMKLGDNGEAFFVQETDNDQEVIPMHLATSPILSEGASRMECQL 120

Query: 121 KRGSVDRMRGLDPSTPAQVIAPSETPSSSSVVKKRRKRRRKSQLDSLKRDDNMNTSEDED 180
           KRGSVDRMRGLDPSTPAQVIAPSETPSSSSVVKKRRKRRRKSQLDSLKRDDNMNTSEDED
Sbjct: 121 KRGSVDRMRGLDPSTPAQVIAPSETPSSSSVVKKRRKRRRKSQLDSLKRDDNMNTSEDED 180

Query: 181 MFPIEMSSDEAMELLESSRTLPNDIPPFQDDIPEENLSLAVIYPQSASYPNSDREWSPTP 240
           MFPIEMSSDEAMELLESSRTLPNDIPPFQDDIPEENLSLAVIYPQSASYPNSDREWSPTP
Sbjct: 181 MFPIEMSSDEAMELLESSRTLPNDIPPFQDDIPEENLSLAVIYPQSASYPNSDREWSPTP 240

Query: 241 SPSGSRPSTPKSDSELVSKSTERTGQKNPEMLWLWGELPQAAKSSSPHKMKESSPLSSRK 300
           SPSGSRPSTPKSDSELVSKSTERTGQKNPEMLWLWGELPQAAKSSSPHKMKESSPLSSRK
Sbjct: 241 SPSGSRPSTPKSDSELVSKSTERTGQKNPEMLWLWGELPQAAKSSSPHKMKESSPLSSRK 300

Query: 301 ICDKSHFQAIHSESSDTFSDQSPTLVGGALLDQNKPQTEMQFVNEEDLETLGAAAPLLPM 360
           ICDKSHFQAIHSESSDTFSDQSPTLVGGALLDQNKPQTEMQFVNEEDLETLGAAAPLLPM
Sbjct: 301 ICDKSHFQAIHSESSDTFSDQSPTLVGGALLDQNKPQTEMQFVNEEDLETLGAAAPLLPM 360

Query: 361 IEELKPPSASVVQTANKTDSPSRKRDKRSRHLGADGVYLDDLTDMDPEVAALYFPKNGDP 420
           IEELKPPSASVVQTANKTDSPSRKRDKRSRHLGADGVYLDDLTDMDPEVAALYFPKNGDP
Sbjct: 361 IEELKPPSASVVQTANKTDSPSRKRDKRSRHLGADGVYLDDLTDMDPEVAALYFPKNGDP 420

Query: 421 SGLAKHASDNGARSANQSPQSVGSSGVDSGVESTSDGLRDLPSIAISLCGGLSDHREITK 480
           SGLAKHASDNGARSANQSPQSVGSSGVDSGVESTSDGLRDLPSIAISLCGGLSDHREITK
Sbjct: 421 SGLAKHASDNGARSANQSPQSVGSSGVDSGVESTSDGLRDLPSIAISLCGGLSDHREITK 480

Query: 481 DAFLEQAVSYQQFVDNPAIIDDPNLVVKIGSKYYNWTTAAPLLLAMQAFQKPLPKATVES 540
           DAFLEQAVSYQQFVDNPAIIDDPNLVVKIGSKYYNWTTAAPLLLAMQAFQKPLPKATVES
Sbjct: 481 DAFLEQAVSYQQFVDNPAIIDDPNLVVKIGSKYYNWTTAAPLLLAMQAFQKPLPKATVES 540

Query: 541 IMRDKMPKKGGRWWFSWRGRNTTIKEESKPEQCLAGKAHSTGEQPPQLSLATRVKHESSS 600
           IMRDKMPKKGGRWWFSWRGRNTTIKEESKPEQCLAGKAHSTGEQPPQLSLATRVKHESSS
Sbjct: 541 IMRDKMPKKGGRWWFSWRGRNTTIKEESKPEQCLAGKAHSTGEQPPQLSLATRVKHESSS 600

Query: 601 SDEERAAAKPSNAGHLPLLPNVSYKKTLRLTSEQLKSLKLKNGPNDVVFSVTTQYQGTCR 660
           SDEERAAAKPSNAGHLPLLPNVSYKKTLRLTSEQLKSLKLKNGPNDVVFSVTTQYQGTCR
Sbjct: 601 SDEERAAAKPSNAGHLPLLPNVSYKKTLRLTSEQLKSLKLKNGPNDVVFSVTTQYQGTCR 660

Query: 661 CEGTIYLWNWDDKVIISDIDGTITRSDTLGHILPTLGKDWTHQGIAKLYHKVSQNGYKFL 720
           CEGTIYLWNWDDKVIISDIDGTITRSDTLGHILPTLGKDWTHQGIAKLYHKVSQNGYKFL
Sbjct: 661 CEGTIYLWNWDDKVIISDIDGTITRSDTLGHILPTLGKDWTHQGIAKLYHKVSQNGYKFL 720

Query: 721 YCSARAIGMADMTRGYLHWVNERGTVLPQGPLLLSPSSLFSALHREVIEKKPEKFKVQCL 780
           YCSARAIGMADMTRGYLHWVNERGTVLPQGPLLLSPSSLFSALHREVIEKKPEKFKVQCL
Sbjct: 721 YCSARAIGMADMTRGYLHWVNERGTVLPQGPLLLSPSSLFSALHREVIEKKPEKFKVQCL 780

Query: 781 TDIKNLFFPNTEPFYAAFGNRPADVYSYKQVGVSLNRIFTVNPKGELVQEHAKTNISSYV 840
           TDIKNLFFPNTEPFYAAFGNRPADVYSYKQVGVSLNRIFTVNPKGELVQEHAKTNISSYV
Sbjct: 781 TDIKNLFFPNTEPFYAAFGNRPADVYSYKQVGVSLNRIFTVNPKGELVQEHAKTNISSYV 840

Query: 841 RLCEVVDHVFPLLKRSHSSDFPCSDTFSNFTFWREPLPPFENQDIHSASA 890
           RLCEVVDHVFPLLKRSHSSDFPCSDTFSNFTFWREPLPPFENQDIHSASA
Sbjct: 841 RLCEVVDHVFPLLKRSHSSDFPCSDTFSNFTFWREPLPPFENQDIHSASA 890


>gi|7662022 lipin 2 [Homo sapiens]
          Length = 896

 Score =  867 bits (2239), Expect = 0.0
 Identities = 465/913 (50%), Positives = 615/913 (67%), Gaps = 46/913 (5%)

Query: 1   MNYVGQLAGQVFVTVKELYKGLNPATLSGCIDIIVIRQPNGNLQCSPFHVRFGKMGVLRS 60
           MNYVGQLAGQV VTVKELYKG+N ATLSGCID+IV++Q +G+ QCSPFHVRFGK+GVLRS
Sbjct: 1   MNYVGQLAGQVIVTVKELYKGINQATLSGCIDVIVVQQQDGSYQCSPFHVRFGKLGVLRS 60

Query: 61  REKVVDIEINGESVDLHMKLGDNGEAFFVQETDNDQEVIPMHLATSPILSEGA--SRMEC 118
           +EKV+DIEING +VDLHMKLGDNGEAFFV+ET+ + E +P +LATSPI +E      ++ 
Sbjct: 61  KEKVIDIEINGSAVDLHMKLGDNGEAFFVEETEEEYEKLPAYLATSPIPTEDQFFKDIDT 120

Query: 119 QLKRGSVDRMRGLDPSTPAQV--IAPSETPSSSSVVKKRRKRRRKSQLDSLKRDDNMNTS 176
            L +   D      PS  + +  +  +ET  + S VKK+++RR+K + DS K+++   ++
Sbjct: 121 PLVKSGGDET----PSQSSDISHVLETETIFTPSSVKKKKRRRKKYKQDS-KKEEQAASA 175

Query: 177 EDEDMFPIEMSSDEAMELLESSRTLPNDIPPFQDDIPEENLSLAVIYPQSASYPNSDREW 236
             ED   + +SSD+     +++R   N        + EE     +++     YP SD +W
Sbjct: 176 AAEDTCDVGVSSDDDKGA-QAARGSSNA------SLKEEECKEPLLFHSGDHYPLSDGDW 228

Query: 237 SPTPSPSGSRPSTPKSDSELVSKSTERTGQKNPEMLWLWGELPQAAKSSSPHKMKESSPL 296
           SP  + +  + + PKSDSEL  K  E   +    M W WG  P++ K S   +       
Sbjct: 229 SPLET-TYPQTACPKSDSELEVKPAESLLRSESHMEWTWGGFPESTKVSKRERSDHHPRT 287

Query: 297 SSRKICDKSHFQAIHSESS--------DTFSDQSPTLVGG---ALLDQNKPQTEMQFVNE 345
           ++    + +HF+ I SE +         +  D   T+V     AL  Q    T +  + E
Sbjct: 288 ATITPSENTHFRVIPSEDNLISEVEKDASMEDTVCTIVKPKPRALGTQMSDPTSVAELLE 347

Query: 346 EDLETLGAAAPL----LPMIEELKPPSASVVQTANKTDSPSRKRD--KRSRHLGADGVYL 399
             LE+   ++ L    LP     + PS S  + A K DSPS+K+   KRS+H G D +YL
Sbjct: 348 PPLESTQISSMLDADHLPNAALAEAPSES--KPAAKVDSPSKKKGVHKRSQHQGPDDIYL 405

Query: 400 DDLTDMDPEVAALYFPKNGDPSGLAKHASDNGARSANQSPQSVGSSGVDSGVESTSDGLR 459
           DDL  ++PEVAALYFPK+    G ++   ++   S +QSPQSVGS+  DSG E  SD   
Sbjct: 406 DDLKGLEPEVAALYFPKSESEPG-SRQWPESDTLSGSQSPQSVGSAAADSGTECLSDSAM 464

Query: 460 DLPSIAISLCGGLSDHREITKDAFLEQAVSYQQFVDNPAIIDDPNLVVKIGSKYYNWTTA 519
           DLP + +SLCGGLS++ EI+K+ F+E  ++Y +F +NP +ID+PNLV++I ++YYNW  A
Sbjct: 465 DLPDVTLSLCGGLSENGEISKEKFMEHIITYHEFAENPGLIDNPNLVIRIYNRYYNWALA 524

Query: 520 APLLLAMQAFQKPLPKATVESIMRDKMPKKGGRWWFSWRGRNTTIKE--ESKPEQCLAGK 577
           AP++L++Q FQK LPKATVES ++DKMPKK GRWWF WR R +  K+  ESK  +  A  
Sbjct: 525 APMILSLQVFQKSLPKATVESWVKDKMPKKSGRWWF-WRKRESMTKQLPESKEGKSEAPP 583

Query: 578 AHSTGEQPPQLSLATRVKHESSSSDEERAAAKPSNAGHLPLLP-----NVSYKKTLRLTS 632
           A        + + A   +++SSS +  +   +      +P  P       SYKK+LRL+S
Sbjct: 584 ASDLPSSSKEPAGARPAENDSSSDEGSQELEESITVDPIPTEPLSHGSTTSYKKSLRLSS 643

Query: 633 EQLKSLKLKNGPNDVVFSVTTQYQGTCRCEGTIYLWNWDDKVIISDIDGTITRSDTLGHI 692
           +Q+  LKL +GPNDVVFS+TTQYQGTCRC GTIYLWNW+DK+IISDIDGTIT+SD LG I
Sbjct: 644 DQIAKLKLHDGPNDVVFSITTQYQGTCRCAGTIYLWNWNDKIIISDIDGTITKSDALGQI 703

Query: 693 LPTLGKDWTHQGIAKLYHKVSQNGYKFLYCSARAIGMADMTRGYLHWVNERGTVLPQGPL 752
           LP LGKDWTHQGIAKLYH +++NGYKFLYCSARAIGMADMTRGYLHWVN++GT+LP+GPL
Sbjct: 704 LPQLGKDWTHQGIAKLYHSINENGYKFLYCSARAIGMADMTRGYLHWVNDKGTILPRGPL 763

Query: 753 LLSPSSLFSALHREVIEKKPEKFKVQCLTDIKNLFFPNTEPFYAAFGNRPADVYSYKQVG 812
           +LSPSSLFSA HREVIEKKPEKFK++CL DIKNLF P+ +PFYAAFGNRP DVY+Y QVG
Sbjct: 764 MLSPSSLFSAFHREVIEKKPEKFKIECLNDIKNLFAPSKQPFYAAFGNRPNDVYAYTQVG 823

Query: 813 VSLNRIFTVNPKGELVQEHAKTNISSYVRLCEVVDHVFPLLKRSHSSDFPCSDTFSNFTF 872
           V   RIFTVNPKGEL+QE  K N SSY RL E+V+HVFPLL +  +S FPC + FS+F +
Sbjct: 824 VPDCRIFTVNPKGELIQERTKGNKSSYHRLSELVEHVFPLLSKEQNSAFPCPE-FSSFCY 882

Query: 873 WREPLPPFENQDI 885
           WR+P+P  +  D+
Sbjct: 883 WRDPIPEVDLDDL 895


>gi|74271888 lipin 3 [Homo sapiens]
          Length = 851

 Score =  748 bits (1932), Expect = 0.0
 Identities = 429/900 (47%), Positives = 563/900 (62%), Gaps = 79/900 (8%)

Query: 1   MNYVGQLAGQVFVTVKELYKGLNPATLSGCIDIIVIRQPNGNLQCSPFHVRFGKMGVLRS 60
           MNYVGQLA  VF TVKELY+GLNPATLSG ID++V++Q +G+ +CSPFHVRFGK+GVLRS
Sbjct: 1   MNYVGQLAETVFGTVKELYRGLNPATLSGGIDVLVVKQVDGSFRCSPFHVRFGKLGVLRS 60

Query: 61  REKVVDIEINGESVDLHMKLGDNGEAFFVQETDNDQEVIPMHLATSPILSEGASRMECQL 120
           REKVVDIE+NGE VDLHMKLGD+GEAFFVQE ++D E +P  L TSPI   G S      
Sbjct: 61  REKVVDIELNGEPVDLHMKLGDSGEAFFVQELESDDEHVPPGLCTSPIPWGGLSGFPSDS 120

Query: 121 KRGSVDRMRGLDPSTPAQVIAPSETPSSSSVVKKRRKRRRKSQLDSLKRDDNMNTSEDED 180
           + G+     GL       V+A      ++S  +++R+RRRK +             + ED
Sbjct: 121 QLGTASEPEGL-------VMA-----GTASTGRRKRRRRRKPK-------------QKED 155

Query: 181 MFPIEMSSDEAMELLESSRTLPNDIPPFQDDIPEENLSLAVIYPQSASYPNSDREWSPTP 240
               + S +E     ES  +LP  + P    +  E  S   + P+   YP SD EW P  
Sbjct: 156 AVATDSSPEELEAGAESELSLPEKLRPEPPGVQLEEKSS--LQPKDI-YPYSDGEWPPQA 212

Query: 241 SPSGSRPSTPKSDSELVSKSTERTGQK-NPEMLWLWGELPQAAKSSSPH-------KMKE 292
           S S    ++PKSDSEL  ++ E +  +    M W WG LP+ A++  P        +   
Sbjct: 213 SLSAGELTSPKSDSELEVRTPEPSPLRAESHMQWAWGRLPKVARAERPESSVVLEGRAGA 272

Query: 293 SSP------LSSRKICDKSHFQAIHSESSDTFSD-----QSPTLVGGALLDQNKPQTEMQ 341
           +SP        S  +        +  + ++  +D     + PTLVG  L      +++ Q
Sbjct: 273 TSPPRGGPSTPSTSVAGGVDPLGLPIQQTEAGADLQPDTEDPTLVGPPLHTPETEESKTQ 332

Query: 342 FVNEEDLETLGAAAPLLPMIEELKPPSASVVQTANKTDSPSRKRDKRSRHLGADGVYLDD 401
              +  L     +     +  E+  P+    + +    SP     KRS+HLG   +YLDD
Sbjct: 333 SSGDMGLPPASKSWSWATL--EVPVPTGQPERVSRGKGSP-----KRSQHLGPSDIYLDD 385

Query: 402 LTDMDPEVAALYFPKNGDPSGLAKHASDNGAR--SANQSPQSVGSSGVDSGVESTSDGLR 459
           L  +D E AALYFP++   SGL       GAR  S   S +S+     +   E T D   
Sbjct: 386 LPSLDSENAALYFPQSD--SGL-------GARRWSEPSSQKSLRDPNPEHEPEPTLD--- 433

Query: 460 DLPSIAISLCGGLSDHREITKDAFLEQAVSYQQFVDNPAIIDDPNLVVKIGSKYYNWTTA 519
            + +IA+SLCGGL+D R+I+ + F + +VSYQ    NP ++DDPNLVVKI  K+YNW  A
Sbjct: 434 TVDTIALSLCGGLADSRDISLEKFNQHSVSYQDLTKNPGLLDDPNLVVKINGKHYNWAVA 493

Query: 520 APLLLAMQAFQKPLPKATVESIMRDKMPKKGGRWWFSWRGRNTTIKEESKPEQCLAGKAH 579
           AP++L++QAFQK LPK+T++ + R+KMP+KGGRWWFSWR R+   +E S  ++  A K  
Sbjct: 494 APMILSLQAFQKNLPKSTMDKLEREKMPRKGGRWWFSWRRRDFLAEERSAQKEKTAAKEQ 553

Query: 580 STGEQPPQLSLATRVKHESSSSDEERAAAKPSNAGHLPLLPNV-SYKKTLRLTSEQLKSL 638
             GE+   LS       +  + D       PS     P  P+  +YKK+LRL+S+Q++ L
Sbjct: 554 Q-GEKTEVLS------SDDDAPDSPVILEIPSLPPSTP--PSTPTYKKSLRLSSDQIRRL 604

Query: 639 KLKNGPNDVVFSVTTQYQGTCRCEGTIYLWNWDDKVIISDIDGTITRSDTLGHILPTLGK 698
            L+ G NDVVFSVTTQYQGTCRC+ TIYLW WDDKV+ISDIDGTIT+SD LGHILP LGK
Sbjct: 605 NLQEGANDVVFSVTTQYQGTCRCKATIYLWKWDDKVVISDIDGTITKSDALGHILPQLGK 664

Query: 699 DWTHQGIAKLYHKVSQNGYKFLYCSARAIGMADMTRGYLHWVNERGTVLPQGPLLLSPSS 758
           DWTHQGI  LYHK+  NGYKFLYCSARAIGMAD+T+GYL WV+E G  LP+GP+LLSPSS
Sbjct: 665 DWTHQGITSLYHKIQLNGYKFLYCSARAIGMADLTKGYLQWVSEGGCSLPKGPILLSPSS 724

Query: 759 LFSALHREVIEKKPEKFKVQCLTDIKNLFFPNTEPFYAAFGNRPADVYSYKQVGVSLNRI 818
           LFSALHREVIEKKPE FKV CL+DI+ LF P+ +PFYAAFGNRP DV++Y+QVG+  +RI
Sbjct: 725 LFSALHREVIEKKPEVFKVACLSDIQQLFLPHGQPFYAAFGNRPNDVFAYRQVGLPESRI 784

Query: 819 FTVNPKGELVQEHAKTNISSYVRLCEVVDHVFPLLKRSHSSDFPCSDTFSNFTFWREPLP 878
           FTVNP+GEL+QE  K + S+Y RL EVV+ +FP + R  S+D   +  +SNF +WREPLP
Sbjct: 785 FTVNPRGELIQELIKNHKSTYERLGEVVELLFPPVARGPSTDL-ANPEYSNFCYWREPLP 843


>gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2
           [Homo sapiens]
          Length = 1481

 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 61/257 (23%), Positives = 96/257 (37%), Gaps = 39/257 (15%)

Query: 69  INGESVDLHMKLGDNGEAFFVQETDNDQEVIPMHLATSPILSEGASRMECQLKRGSVDRM 128
           I+G S   + +  D G+A   + +  +     +H        +  +R E +LK G  DR 
Sbjct: 147 ISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH--------KEKTRKERELKSGHKDRS 198

Query: 129 RGLDPSTPAQVIAPSETPSSSSVVKKRRKRRR---KSQLDSLKRDDNMNTSEDEDMFPIE 185
           +              ETP S   V   ++R R   +   DS K+DD+ + +     + + 
Sbjct: 199 KSH---------RKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLS 249

Query: 186 MSSDEAMELLESSRTLPNDIPPFQDDIPEENLSLAVIYPQSASYPNSDREWSPTPSPSGS 245
            S        +S +  P      Q   P         Y + ++Y +S R    +PSP   
Sbjct: 250 PSRSHTSSNYDSYKKSPGSTSRRQSVSPP--------YKEPSAYQSSTR----SPSPYSR 297

Query: 246 RPSTPKSDSELVSKSTERTGQKNPEMLWLWGELPQAAKSSSPHKMKES---SPLSSRKIC 302
           R  +    S   S S ER+G  +      +G      +SSSP   K S   SPL SRK  
Sbjct: 298 RQRSVSPYSRRRSSSYERSGSYSGRSPSPYGR----RRSSSPFLSKRSLSRSPLPSRKSM 353

Query: 303 DKSHFQAIHSESSDTFS 319
                   +S  S + S
Sbjct: 354 KSRSRSPAYSRHSSSHS 370


>gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1
           [Homo sapiens]
          Length = 1490

 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 61/257 (23%), Positives = 96/257 (37%), Gaps = 39/257 (15%)

Query: 69  INGESVDLHMKLGDNGEAFFVQETDNDQEVIPMHLATSPILSEGASRMECQLKRGSVDRM 128
           I+G S   + +  D G+A   + +  +     +H        +  +R E +LK G  DR 
Sbjct: 147 ISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH--------KEKTRKERELKSGHKDRS 198

Query: 129 RGLDPSTPAQVIAPSETPSSSSVVKKRRKRRR---KSQLDSLKRDDNMNTSEDEDMFPIE 185
           +              ETP S   V   ++R R   +   DS K+DD+ + +     + + 
Sbjct: 199 KSH---------RKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLS 249

Query: 186 MSSDEAMELLESSRTLPNDIPPFQDDIPEENLSLAVIYPQSASYPNSDREWSPTPSPSGS 245
            S        +S +  P      Q   P         Y + ++Y +S R    +PSP   
Sbjct: 250 PSRSHTSSNYDSYKKSPGSTSRRQSVSPP--------YKEPSAYQSSTR----SPSPYSR 297

Query: 246 RPSTPKSDSELVSKSTERTGQKNPEMLWLWGELPQAAKSSSPHKMKES---SPLSSRKIC 302
           R  +    S   S S ER+G  +      +G      +SSSP   K S   SPL SRK  
Sbjct: 298 RQRSVSPYSRRRSSSYERSGSYSGRSPSPYGR----RRSSSPFLSKRSLSRSPLPSRKSM 353

Query: 303 DKSHFQAIHSESSDTFS 319
                   +S  S + S
Sbjct: 354 KSRSRSPAYSRHSSSHS 370


>gi|132626688 mediator of DNA-damage checkpoint 1 [Homo sapiens]
          Length = 2089

 Score = 40.8 bits (94), Expect = 0.006
 Identities = 70/292 (23%), Positives = 105/292 (35%), Gaps = 41/292 (14%)

Query: 110  SEGASRMEC--QLKRGSVDRMRGLDPSTPAQVIAPSETPSSSSVVKKRRKRRRKSQLDSL 167
            +E ASR+    ++ RG  +      P T  +  AP + P +S   K        S L   
Sbjct: 1014 AEKASRIRAAEKVSRGDQESPDACLPPTVPEAPAPPQKPLNSQSQKHLAPPPLLSPLLPS 1073

Query: 168  KRDDNMNTSEDEDMFPIEMSSDEAMELLESSRTLPNDIPPFQDDIPEENLSLAVIYPQSA 227
             +     T +D         S EA E   SS   P    P    I     S    +P ++
Sbjct: 1074 IKPTVRKTRQD--------GSQEAPEAPLSSELEPFHPKP---KIRTRKSSRMTPFPATS 1122

Query: 228  SYPNSDREWSPTPSPSGSRPSTPKSDSELVSKSTERTGQKNPEMLWLWGELPQAAKSSSP 287
            + P       P PS S ++P TPK  S+     T R+  K PE   +    P+   S+S 
Sbjct: 1123 AAPE------PHPSTSTAQPVTPKPTSQATRSRTNRSSVKTPEP--VVPTAPELQPSTST 1174

Query: 288  HKMKESSPLSSRKICDKSHFQAIHSESSDTFSDQSPTLVGGALLDQNKPQTEMQFVNE-- 345
             +   S P S          Q      S +      T+V  AL  Q    T+    +E  
Sbjct: 1175 DQPVTSEPTS----------QVTRGRKSRSSVKTPETVVPTALELQPSTSTDRPVTSEPT 1224

Query: 346  -------EDLETLGAAAPLLPMIEELKP-PSASVVQTANKTDSPSRKRDKRS 389
                   ++  ++    P++P   EL+P  S     T+  T   +R R  RS
Sbjct: 1225 SQATRGRKNRSSVKTPEPVVPTAPELQPSTSTDQPVTSEPTYQATRGRKNRS 1276



 Score = 34.3 bits (77), Expect = 0.53
 Identities = 48/204 (23%), Positives = 72/204 (35%), Gaps = 36/204 (17%)

Query: 97   EVIPMHLATSPILSEGASRMECQLKRGSVDRMRGLDPSTPA------QVIAPSETPSSSS 150
            E+ P      P+  E  S    Q  RG  DR     P T        Q  A ++ P +S 
Sbjct: 1454 ELQPSTSTDQPVTPEPTS----QATRGRTDRSSVKTPETVVPTAPELQASASTDQPVTSE 1509

Query: 151  VVKKRRKRRRKSQLDSLKRDDNM---------NTSEDEDMFPIEMSSDEAMELLESSRTL 201
                R  R RK++  S+K  + +         +TS D+ + P   S         SS   
Sbjct: 1510 PTS-RTTRGRKNR-SSVKTPETVVPAAPELQPSTSTDQPVTPEPTSRATRGRTNRSSVKT 1567

Query: 202  PNDIPPFQDDIPEENLSLAVIYPQSASYPN---SDREWSPTPSP------------SGSR 246
            P  I P   ++        ++ P+  S      ++R    TP P            S  +
Sbjct: 1568 PESIVPIAPELQPSTSRNQLVTPEPTSRATRCRTNRSSVKTPEPVVPTAPEPHPTTSTDQ 1627

Query: 247  PSTPKSDSELVSKSTERTGQKNPE 270
            P TPK  S    + T R+  K P+
Sbjct: 1628 PVTPKLTSRATRRKTNRSSVKTPK 1651



 Score = 33.5 bits (75), Expect = 0.90
 Identities = 62/302 (20%), Positives = 102/302 (33%), Gaps = 37/302 (12%)

Query: 92   TDNDQEVIPMHLATSPILSEGASRMECQLKRGSVDRMRGLDPSTPA-QVIAPSETPSSSS 150
            T  DQ V P    TS       +    +    +V     L PST   Q + P  T  ++ 
Sbjct: 1336 TSTDQPVTPK--PTSRTTRSRTNMSSVKNPESTVPIAPELPPSTSTEQPVTPEPTSRATR 1393

Query: 151  VVKKRRKRRRKSQLDSLKRDDNMNTSEDEDMFPIEMSSDEAMELLESSRTLPNDIPPFQD 210
              K R   +    L         +TS D+ + P   S         SS   P  + P   
Sbjct: 1394 GRKNRSSGKTPETLVPTAPKLEPSTSTDQPVTPEPTSQATRGRTNRSSVKTPETVVPTAP 1453

Query: 211  DIPEENLSLAVIYPQSASYPNSDREWSPTPSPSGSRPSTPKSDSELVSKSTERTGQKNPE 270
            ++                           PS S  +P TP+  S+     T+R+  K PE
Sbjct: 1454 ELQ--------------------------PSTSTDQPVTPEPTSQATRGRTDRSSVKTPE 1487

Query: 271  MLWLWGELPQAAKSSSPHKMKESSPLSSRKICDKSHFQAIHSESSDTFSDQSPTLVGGAL 330
             +       QA+ S+      E +  ++R   ++S       ++ +T    +P L     
Sbjct: 1488 TVVPTAPELQASASTDQPVTSEPTSRTTRGRKNRSSV-----KTPETVVPAAPELQPSTS 1542

Query: 331  LDQ--NKPQTEMQFVNEEDLETLGAAAPLLPMIEELKP-PSASVVQTANKTDSPSRKRDK 387
             DQ      T        +  ++     ++P+  EL+P  S + + T   T   +R R  
Sbjct: 1543 TDQPVTPEPTSRATRGRTNRSSVKTPESIVPIAPELQPSTSRNQLVTPEPTSRATRCRTN 1602

Query: 388  RS 389
            RS
Sbjct: 1603 RS 1604


>gi|155722990 solute carrier family 4 (anion exchanger), member 1,
           adaptor protein [Homo sapiens]
          Length = 796

 Score = 40.8 bits (94), Expect = 0.006
 Identities = 33/167 (19%), Positives = 68/167 (40%), Gaps = 8/167 (4%)

Query: 105 TSPILSEGASRMECQLKRGSVDRMRGLDPSTPAQVIAPSETPSSSSVVKKRRKRRRKSQL 164
           T P+        + +LK G+V ++    P  P  ++   + P      ++  +  ++ + 
Sbjct: 604 TLPLFGAMKGGSKFKLKTGTVGKLPPKRPELPPTLMRMKDEPEVEEEEEEEEEEEKEKEE 663

Query: 165 DSLKRDDNMNTSEDEDMFPIEMSSDEAMELLESSRTLPNDIPPFQDDIPEENLSLAVIYP 224
              K+ ++ + S  +     E+  + A++ +      P D+  F++    EN+S      
Sbjct: 664 HEKKKLEDGSLSRPQP----EIEPEAAVQEMRP----PTDLTHFKETQTHENMSQLSEEE 715

Query: 225 QSASYPNSDREWSPTPSPSGSRPSTPKSDSELVSKSTERTGQKNPEM 271
           Q+  Y +  +  S    PS S+    KS  EL  K T   G+  P +
Sbjct: 716 QNKDYQDCSKTTSLCAGPSASKNEYEKSRGELKKKKTPGPGKLPPTL 762


>gi|56550039 myeloid/lymphoid or mixed-lineage leukemia protein [Homo
            sapiens]
          Length = 3969

 Score = 40.0 bits (92), Expect = 0.010
 Identities = 90/376 (23%), Positives = 153/376 (40%), Gaps = 66/376 (17%)

Query: 130  GLDPSTPAQVIAPSETPS-SSSVVKKRRKRRRKSQLDSLKRDDNMNTSEDEDM----FPI 184
            GL P    +     + P  SSS  KKR KR  + Q+D     D+++TS+++D+    F  
Sbjct: 2630 GLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGA---DDLSTSDEDDLYYYNFTR 2686

Query: 185  EMSSDEAMELLESSRTLPN----DIPPFQ-----DDIPEENLSLAVIYPQSASYPNSDRE 235
             + S    E L S          D+P        DD  E + S+     +S+  P  + +
Sbjct: 2687 TVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGK 2746

Query: 236  WSPTPSPSGSRPSTPKSDSELVSKSTERTGQKN-PEM--------LWLWGELPQAAKSSS 286
             + T +    RP     + E V+KS+   G KN P+M        +   G+    A+ SS
Sbjct: 2747 ENGTENLKIDRPE-DAGEKEHVTKSS--VGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSS 2803

Query: 287  PHKMK--ESSPLSSRKICDKSHFQAIHSESSDTFSDQSPTLVGGALLD---QNKPQTEMQ 341
                +   +S  S + + D  + + + S+S +  SD    ++   ++D   +N P   MQ
Sbjct: 2804 LESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTP--SMQ 2861

Query: 342  FVNE------EDLETLGAAAPL---------LPMIEELKPPSASVVQTANKTDSPSRKRD 386
             + E       +L  LG    L         L  +   + P+   V ++  +   + ++ 
Sbjct: 2862 ALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQF 2921

Query: 387  KRSRHLGADGVYLDDLTDMDPEVAALYFPKNGDPSGLAKHASDNGARSANQSPQSVGSSG 446
            +    L +D   L  LT   P V       + +PS LA   SD+G +    + +SV SS 
Sbjct: 2922 ELPLELPSD---LSVLTTRSPTV------PSQNPSRLAV-ISDSGEKRVTITEKSVASSE 2971

Query: 447  VD-----SGVESTSDG 457
             D      GV+ T +G
Sbjct: 2972 SDPALLSPGVDPTPEG 2987



 Score = 30.4 bits (67), Expect = 7.6
 Identities = 41/156 (26%), Positives = 56/156 (35%), Gaps = 18/156 (11%)

Query: 146 PSSSSVVKKRRKRRRKSQLDSLKRDDNMNTSEDEDMFPIEMSSDEAMELLESSRTLPNDI 205
           PS  S  K     +  SQ+ S   D + ++S   D      +S+E   L E     P   
Sbjct: 454 PSCGSSEKSSAASQHSSQMSS---DSSRSSSPSVDTSTDSQASEEIQVLPEERSDTPEVH 510

Query: 206 PPFQDDIPEENLSLAVIYPQSASYPNSDREWSPTPSPSGSRPSTPKSDSELVSKSTERTG 265
           PP                P++ S     R +S +    GSR  T K  S L S   ++T 
Sbjct: 511 PPLPISQS----------PENESNDRRSRRYSVSERSFGSR--TTKKLSTLQSAPQQQTS 558

Query: 266 QKNPEMLWLWGELPQAAKSSSPHK---MKESSPLSS 298
              P  L       Q A S S H    M  + PL+S
Sbjct: 559 SSPPPPLLTPPPPLQPASSISDHTPWLMPPTIPLAS 594


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score = 39.7 bits (91), Expect = 0.013
 Identities = 60/291 (20%), Positives = 113/291 (38%), Gaps = 54/291 (18%)

Query: 113  ASRMECQLKRGSVDRMRGLDPSTPAQVIAPSETPS---SSSVVKKRRKRRRKSQLDSLKR 169
            AS  + +LK+GS +   G DP      +AP   P+   +S ++++      K ++ +L++
Sbjct: 1721 ASAEKAELKKGSSEESLGEDPG-----LAPEPLPTVKATSPLIEETPIGSIKDKVKALQK 1775

Query: 170  DDNMNTSEDEDMFPIEMSSDEAMELLESSRTLPNDIPPFQDDIPEENLSLAVIYPQSASY 229
                +  +     PI +   E                    D+P++       +P ++  
Sbjct: 1776 RVE-DEQKGRSKLPIRVKGKE--------------------DVPKKTTHRP--HPAASPS 1812

Query: 230  PNSDREWSPTPSPSGSRPSTPKSDSELV-------SKSTERTGQKNPEMLWLWGELPQAA 282
              S+R    +PSP   R ST  S ++         S  TE+    +P       +  + +
Sbjct: 1813 LKSERHAPGSPSPKTERHSTLSSSAKTERHPPVSPSSKTEKHSPVSPS-----AKTERHS 1867

Query: 283  KSSSPHKMKESSPLSSRKICDKSHFQAIHSESSDTFSDQSPTLVGGALLDQNKPQTEMQF 342
             +SS  K ++ SP+S     ++      HS  S T +++ P +      D+  P +    
Sbjct: 1868 PASSSSKTEKHSPVSPSTKTER------HSPVSSTKTERHPPVSPSGKTDKRPPVSPSGR 1921

Query: 343  VNEEDLETLGAAAPLLPMIEELKPPSASVVQTANKTD-----SPSRKRDKR 388
              +    + G     LP+    +      V TA KT+     SPS K +K+
Sbjct: 1922 TEKHPPVSPGRTEKRLPVSPSGRTDKHQPVSTAGKTEKHLPVSPSGKTEKQ 1972


>gi|21361272 myeloid/lymphoid or mixed-lineage leukemia (trithorax
           homolog, Drosophila); translocated to, 1 [Homo sapiens]
          Length = 559

 Score = 39.3 bits (90), Expect = 0.016
 Identities = 65/319 (20%), Positives = 121/319 (37%), Gaps = 49/319 (15%)

Query: 143 SETPSSSSVVKKRRKRRRKSQLDSLKRDDNMNTSEDEDMFPIEMSSDEAMELLESSRTLP 202
           S+T     V K+ R+R RK         ++ ++S++ +    + S D + +L E      
Sbjct: 189 SKTSKPHKVTKEHRERPRKDS-------ESKSSSKELEREQAKSSKDTSRKLGEGRLPKE 241

Query: 203 NDIPPFQDDIPEENLSLAVIYPQSASYPNSDREWSPTPSP--SGSRPST---PKSDSELV 257
              PP +    E  ++L     +S S P       P P P  S  RP+T   PK  ++  
Sbjct: 242 EKAPPPKAAFKEPKMALKETKLESTS-PKGGPPPPPPPPPRASSKRPATADSPKPSAKKQ 300

Query: 258 SKSTERTGQKNPEMLWLWGELPQAAKSSS-----PHKMK----------ESSPLSSRKIC 302
            KS+ +  +  P      G  P+ + SSS     P K K          ES P  ++K  
Sbjct: 301 KKSSSKGSRSAP------GTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKAL 354

Query: 303 DKSHFQAIHSESSDTFSDQSPTLVGGALLDQNKPQTEMQFVNEEDLETLGAAAPLLPMIE 362
           +    +  +SE   +F  +S           +   ++  F   ++     +  PL  M+E
Sbjct: 355 E---VEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQN----HSQGPLRSMVE 407

Query: 363 ELKPPSASVVQTANKTDSPSRKRDKRSRHLGADGVYLDDLTDMDPEVAALYFPKNGDPSG 422
           +L+   +    +++  ++  +    R   L          +D + + +A     + +P  
Sbjct: 408 DLQSEESDEDDSSSGEEAAGKTNPGRDSRL--------SFSDSESDNSADSSLPSREPPP 459

Query: 423 LAKHASDNGARSANQSPQS 441
             K    N   S  +SP+S
Sbjct: 460 PQKPPPPNSKVSGRRSPES 478


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 39.3 bits (90), Expect = 0.016
 Identities = 47/222 (21%), Positives = 79/222 (35%), Gaps = 13/222 (5%)

Query: 90  QETDNDQEVIPMHLA-TSPILSEGASRMECQLKRGSVDRMRGLDPSTPAQVIA------- 141
           +ET + ++     LA TS +L++   + E   K  ++   +   P+TP +  +       
Sbjct: 174 KETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPT 233

Query: 142 PSETPSSSSVVKKRRKRRRKSQLDSLKRDDNMNTSEDEDMFPIE----MSSDEAMELLES 197
           P+   S+ +  K+      KS   + K      T E     P E     + + A    +S
Sbjct: 234 PTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKS 293

Query: 198 SRTLPNDIPPFQDDIPEENLSLAVIYPQSASYPNSDREWSPTPSPSGSRPSTPKSDSELV 257
           + T P +  P     P          P +   P       P P+     P+TPK  +   
Sbjct: 294 APTTPKEPAPTTPKKPAPTTPKEPA-PTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTA 352

Query: 258 SKSTERTGQKNPEMLWLWGELPQAAKSSSPHKMKESSPLSSR 299
            K    T  K P         P   K  SP   KE +P +++
Sbjct: 353 PKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTK 394



 Score = 37.7 bits (86), Expect = 0.048
 Identities = 27/105 (25%), Positives = 41/105 (39%), Gaps = 2/105 (1%)

Query: 196 ESSRTLPNDIPPFQDDIPEENLSLAVIYPQSASYPNSDREWSPTPSPSGSRPSTPKSDSE 255
           E + T P +  P     P            + S P + +E  P P+ + S P+TPK  S 
Sbjct: 363 EPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKE--PAPTTTKSAPTTPKEPSP 420

Query: 256 LVSKSTERTGQKNPEMLWLWGELPQAAKSSSPHKMKESSPLSSRK 300
             +K    T  K P         P   K  +P   KE +P +++K
Sbjct: 421 TTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKK 465



 Score = 37.0 bits (84), Expect = 0.082
 Identities = 42/173 (24%), Positives = 66/173 (38%), Gaps = 9/173 (5%)

Query: 133 PSTPAQVIAPSETPS--SSSVVKKRRKRRRKSQLDSLKR---DDNMNTSEDEDMFPIEMS 187
           P  P   + P+   S  +S  V K      K    + K+   D    T+  ++   IE +
Sbjct: 123 PINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKT 182

Query: 188 SDEAMELLESSRTLPNDIPPFQDDIPEENLSLAVI-YPQSASYPNSDREWSPTPSPSGSR 246
           S  A +L  +S+ L    P  +       L+      P +   P S     PTP+   S 
Sbjct: 183 S--AKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSA 240

Query: 247 PSTPKSDSELVSKSTERTGQKNPEMLWLWGELPQAAKSSSPHKMKESSPLSSR 299
           P+TPK  +   +KS   T  K P         P   K  +P   KE +P +++
Sbjct: 241 PTTPKEPAPTTTKSAPTT-PKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTK 292



 Score = 36.2 bits (82), Expect = 0.14
 Identities = 44/177 (24%), Positives = 65/177 (36%), Gaps = 33/177 (18%)

Query: 224 PQSASYPNSDREWSPTPS-PSGSRPSTPKSDSELVSKSTERTGQKNPEMLWLWGELPQAA 282
           P +   P S     P P+ P G+ P+TPK  +         T  K P         P   
Sbjct: 601 PTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAP--------TTPKEP--------APTTP 644

Query: 283 KSSSPHKMKESSPLSSRKICDKSHFQAIHSESSDTFSDQ-SPTLVGGALLDQNKPQTEMQ 341
           K ++P  +KE +P + +K   K          + T SD+ +PT            +T   
Sbjct: 645 KGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPT---------TPKETAPT 695

Query: 342 FVNEEDLETLGAAAPLLPMIEELKPPSASVVQTANKTDSPS---RKRDKRSRHLGAD 395
              E    T    AP  P   E  PP+ S V T   T  P+   +  D+ +  L A+
Sbjct: 696 TPKEPAPTTPKKPAPTTP---ETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAE 749



 Score = 34.3 bits (77), Expect = 0.53
 Identities = 20/72 (27%), Positives = 32/72 (44%), Gaps = 1/72 (1%)

Query: 230 PNSDREWSPTPSPSGSRPSTPKSDSELVSKSTERTGQKNPEMLWLWGELPQAAKSSSPHK 289
           P + +E +PT +P    P+TPK  +    K    T  K P         P   K  +P  
Sbjct: 420 PTTTKEPAPT-TPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTT 478

Query: 290 MKESSPLSSRKI 301
            KE++P + +K+
Sbjct: 479 PKETAPTTPKKL 490



 Score = 33.5 bits (75), Expect = 0.90
 Identities = 33/157 (21%), Positives = 57/157 (36%), Gaps = 8/157 (5%)

Query: 149 SSVVKKRRKRRRKSQLDSLKRDDNMNTSEDEDMFPIEMSSDEAMELLESSR-----TLPN 203
           ++   K+     K +  S K   ++  +  +D+ P      +     E++      T P 
Sbjct: 155 TTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPK 214

Query: 204 DIPPFQDDIPEENLSLAVIYPQSASYPNSDREWSPTPSPSGSRPSTPKSDSELVSKSTER 263
           +  P     P              S P + +E  P P+ + S P+TPK  +   +K    
Sbjct: 215 EPTPTTPKEPASTTPKEPTPTTIKSAPTTPKE--PAPTTTKSAPTTPKEPAPTTTKEPAP 272

Query: 264 TGQKNPEMLWLWGELPQAAKSSSPHKMKESSPLSSRK 300
           T  K P         P   K S+P   KE +P + +K
Sbjct: 273 TTPKEPAPTTTKEPAPTTTK-SAPTTPKEPAPTTPKK 308



 Score = 32.0 bits (71), Expect = 2.6
 Identities = 36/190 (18%), Positives = 67/190 (35%), Gaps = 22/190 (11%)

Query: 110 SEGASRMECQLKRGSVDRMRGLDPSTPAQVIAPSETPSSSSVVKKRRKRRRKSQLDSLKR 169
           ++G  +     +  S+++    D +  ++V+A   TP + +  K       K    +  +
Sbjct: 164 TDGKEKTTSAKETQSIEKTSAKDLAPTSKVLA-KPTPKAETTTKGPALTTPKEPTPTTPK 222

Query: 170 DDNMNTSEDEDMFPIEMS----SDEAMELLESSRTLPNDIPPFQDDIPEENLSLAVIYPQ 225
           +    T ++     I+ +     + A    +S+ T P +  P     P          P 
Sbjct: 223 EPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPA---------PT 273

Query: 226 SASYPNSDREWSPTPSPSGSRPSTPKSDSELVSKSTERTGQKNPEMLWLWGELPQAAKSS 285
           +   P       P P+ + S P+TPK  +    K    T  K P         P   K  
Sbjct: 274 TPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEP--------APTTPKEP 325

Query: 286 SPHKMKESSP 295
           +P   KE +P
Sbjct: 326 TPTTPKEPAP 335



 Score = 30.8 bits (68), Expect = 5.8
 Identities = 33/139 (23%), Positives = 51/139 (36%), Gaps = 19/139 (13%)

Query: 200 TLPNDIPPFQDDIPEENL--SLAVIYPQSASYPNSDREWSPTP-------SPSGSRPSTP 250
           T P  + P   + P       LA   P+  + P +  E +PT        +P    P+TP
Sbjct: 493 TTPEKLAPTTPEKPAPTTPEELAPTTPEEPT-PTTPEEPAPTTPKAAAPNTPKEPAPTTP 551

Query: 251 KSDSELVSKSTERTGQKNPEMLWLWGELPQAAKSSSPHKMKESSPLSSRKICDKSHFQAI 310
           K  +    K    T  K           P   K ++P  +KE +P + +K   K      
Sbjct: 552 KEPAPTTPKEPAPTTPKE--------TAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTT 603

Query: 311 HSESSDTFSDQ-SPTLVGG 328
             E + T  D+ +PT   G
Sbjct: 604 TKEPTSTTCDKPAPTTPKG 622


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 39.3 bits (90), Expect = 0.016
 Identities = 47/222 (21%), Positives = 79/222 (35%), Gaps = 13/222 (5%)

Query: 90  QETDNDQEVIPMHLA-TSPILSEGASRMECQLKRGSVDRMRGLDPSTPAQVIA------- 141
           +ET + ++     LA TS +L++   + E   K  ++   +   P+TP +  +       
Sbjct: 215 KETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPT 274

Query: 142 PSETPSSSSVVKKRRKRRRKSQLDSLKRDDNMNTSEDEDMFPIE----MSSDEAMELLES 197
           P+   S+ +  K+      KS   + K      T E     P E     + + A    +S
Sbjct: 275 PTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKS 334

Query: 198 SRTLPNDIPPFQDDIPEENLSLAVIYPQSASYPNSDREWSPTPSPSGSRPSTPKSDSELV 257
           + T P +  P     P          P +   P       P P+     P+TPK  +   
Sbjct: 335 APTTPKEPAPTTPKKPAPTTPKEPA-PTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTA 393

Query: 258 SKSTERTGQKNPEMLWLWGELPQAAKSSSPHKMKESSPLSSR 299
            K    T  K P         P   K  SP   KE +P +++
Sbjct: 394 PKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTK 435



 Score = 37.7 bits (86), Expect = 0.048
 Identities = 27/105 (25%), Positives = 41/105 (39%), Gaps = 2/105 (1%)

Query: 196 ESSRTLPNDIPPFQDDIPEENLSLAVIYPQSASYPNSDREWSPTPSPSGSRPSTPKSDSE 255
           E + T P +  P     P            + S P + +E  P P+ + S P+TPK  S 
Sbjct: 404 EPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKE--PAPTTTKSAPTTPKEPSP 461

Query: 256 LVSKSTERTGQKNPEMLWLWGELPQAAKSSSPHKMKESSPLSSRK 300
             +K    T  K P         P   K  +P   KE +P +++K
Sbjct: 462 TTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKK 506



 Score = 37.0 bits (84), Expect = 0.082
 Identities = 42/173 (24%), Positives = 66/173 (38%), Gaps = 9/173 (5%)

Query: 133 PSTPAQVIAPSETPS--SSSVVKKRRKRRRKSQLDSLKR---DDNMNTSEDEDMFPIEMS 187
           P  P   + P+   S  +S  V K      K    + K+   D    T+  ++   IE +
Sbjct: 164 PINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKT 223

Query: 188 SDEAMELLESSRTLPNDIPPFQDDIPEENLSLAVI-YPQSASYPNSDREWSPTPSPSGSR 246
           S  A +L  +S+ L    P  +       L+      P +   P S     PTP+   S 
Sbjct: 224 S--AKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSA 281

Query: 247 PSTPKSDSELVSKSTERTGQKNPEMLWLWGELPQAAKSSSPHKMKESSPLSSR 299
           P+TPK  +   +KS   T  K P         P   K  +P   KE +P +++
Sbjct: 282 PTTPKEPAPTTTKSAPTT-PKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTK 333



 Score = 36.2 bits (82), Expect = 0.14
 Identities = 44/177 (24%), Positives = 65/177 (36%), Gaps = 33/177 (18%)

Query: 224 PQSASYPNSDREWSPTPS-PSGSRPSTPKSDSELVSKSTERTGQKNPEMLWLWGELPQAA 282
           P +   P S     P P+ P G+ P+TPK  +         T  K P         P   
Sbjct: 642 PTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAP--------TTPKEP--------APTTP 685

Query: 283 KSSSPHKMKESSPLSSRKICDKSHFQAIHSESSDTFSDQ-SPTLVGGALLDQNKPQTEMQ 341
           K ++P  +KE +P + +K   K          + T SD+ +PT            +T   
Sbjct: 686 KGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPT---------TPKETAPT 736

Query: 342 FVNEEDLETLGAAAPLLPMIEELKPPSASVVQTANKTDSPS---RKRDKRSRHLGAD 395
              E    T    AP  P   E  PP+ S V T   T  P+   +  D+ +  L A+
Sbjct: 737 TPKEPAPTTPKKPAPTTP---ETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAE 790



 Score = 34.3 bits (77), Expect = 0.53
 Identities = 20/72 (27%), Positives = 32/72 (44%), Gaps = 1/72 (1%)

Query: 230 PNSDREWSPTPSPSGSRPSTPKSDSELVSKSTERTGQKNPEMLWLWGELPQAAKSSSPHK 289
           P + +E +PT +P    P+TPK  +    K    T  K P         P   K  +P  
Sbjct: 461 PTTTKEPAPT-TPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTT 519

Query: 290 MKESSPLSSRKI 301
            KE++P + +K+
Sbjct: 520 PKETAPTTPKKL 531



 Score = 33.5 bits (75), Expect = 0.90
 Identities = 33/157 (21%), Positives = 57/157 (36%), Gaps = 8/157 (5%)

Query: 149 SSVVKKRRKRRRKSQLDSLKRDDNMNTSEDEDMFPIEMSSDEAMELLESSR-----TLPN 203
           ++   K+     K +  S K   ++  +  +D+ P      +     E++      T P 
Sbjct: 196 TTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPK 255

Query: 204 DIPPFQDDIPEENLSLAVIYPQSASYPNSDREWSPTPSPSGSRPSTPKSDSELVSKSTER 263
           +  P     P              S P + +E  P P+ + S P+TPK  +   +K    
Sbjct: 256 EPTPTTPKEPASTTPKEPTPTTIKSAPTTPKE--PAPTTTKSAPTTPKEPAPTTTKEPAP 313

Query: 264 TGQKNPEMLWLWGELPQAAKSSSPHKMKESSPLSSRK 300
           T  K P         P   K S+P   KE +P + +K
Sbjct: 314 TTPKEPAPTTTKEPAPTTTK-SAPTTPKEPAPTTPKK 349



 Score = 32.0 bits (71), Expect = 2.6
 Identities = 36/190 (18%), Positives = 67/190 (35%), Gaps = 22/190 (11%)

Query: 110 SEGASRMECQLKRGSVDRMRGLDPSTPAQVIAPSETPSSSSVVKKRRKRRRKSQLDSLKR 169
           ++G  +     +  S+++    D +  ++V+A   TP + +  K       K    +  +
Sbjct: 205 TDGKEKTTSAKETQSIEKTSAKDLAPTSKVLA-KPTPKAETTTKGPALTTPKEPTPTTPK 263

Query: 170 DDNMNTSEDEDMFPIEMS----SDEAMELLESSRTLPNDIPPFQDDIPEENLSLAVIYPQ 225
           +    T ++     I+ +     + A    +S+ T P +  P     P          P 
Sbjct: 264 EPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPA---------PT 314

Query: 226 SASYPNSDREWSPTPSPSGSRPSTPKSDSELVSKSTERTGQKNPEMLWLWGELPQAAKSS 285
           +   P       P P+ + S P+TPK  +    K    T  K P         P   K  
Sbjct: 315 TPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEP--------APTTPKEP 366

Query: 286 SPHKMKESSP 295
           +P   KE +P
Sbjct: 367 TPTTPKEPAP 376



 Score = 30.8 bits (68), Expect = 5.8
 Identities = 33/139 (23%), Positives = 51/139 (36%), Gaps = 19/139 (13%)

Query: 200 TLPNDIPPFQDDIPEENL--SLAVIYPQSASYPNSDREWSPTP-------SPSGSRPSTP 250
           T P  + P   + P       LA   P+  + P +  E +PT        +P    P+TP
Sbjct: 534 TTPEKLAPTTPEKPAPTTPEELAPTTPEEPT-PTTPEEPAPTTPKAAAPNTPKEPAPTTP 592

Query: 251 KSDSELVSKSTERTGQKNPEMLWLWGELPQAAKSSSPHKMKESSPLSSRKICDKSHFQAI 310
           K  +    K    T  K           P   K ++P  +KE +P + +K   K      
Sbjct: 593 KEPAPTTPKEPAPTTPKE--------TAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTT 644

Query: 311 HSESSDTFSDQ-SPTLVGG 328
             E + T  D+ +PT   G
Sbjct: 645 TKEPTSTTCDKPAPTTPKG 663


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 39.3 bits (90), Expect = 0.016
 Identities = 47/222 (21%), Positives = 79/222 (35%), Gaps = 13/222 (5%)

Query: 90  QETDNDQEVIPMHLA-TSPILSEGASRMECQLKRGSVDRMRGLDPSTPAQVIA------- 141
           +ET + ++     LA TS +L++   + E   K  ++   +   P+TP +  +       
Sbjct: 267 KETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPT 326

Query: 142 PSETPSSSSVVKKRRKRRRKSQLDSLKRDDNMNTSEDEDMFPIE----MSSDEAMELLES 197
           P+   S+ +  K+      KS   + K      T E     P E     + + A    +S
Sbjct: 327 PTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKS 386

Query: 198 SRTLPNDIPPFQDDIPEENLSLAVIYPQSASYPNSDREWSPTPSPSGSRPSTPKSDSELV 257
           + T P +  P     P          P +   P       P P+     P+TPK  +   
Sbjct: 387 APTTPKEPAPTTPKKPAPTTPKEPA-PTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTA 445

Query: 258 SKSTERTGQKNPEMLWLWGELPQAAKSSSPHKMKESSPLSSR 299
            K    T  K P         P   K  SP   KE +P +++
Sbjct: 446 PKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTK 487



 Score = 37.7 bits (86), Expect = 0.048
 Identities = 27/105 (25%), Positives = 41/105 (39%), Gaps = 2/105 (1%)

Query: 196 ESSRTLPNDIPPFQDDIPEENLSLAVIYPQSASYPNSDREWSPTPSPSGSRPSTPKSDSE 255
           E + T P +  P     P            + S P + +E  P P+ + S P+TPK  S 
Sbjct: 456 EPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKE--PAPTTTKSAPTTPKEPSP 513

Query: 256 LVSKSTERTGQKNPEMLWLWGELPQAAKSSSPHKMKESSPLSSRK 300
             +K    T  K P         P   K  +P   KE +P +++K
Sbjct: 514 TTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKK 558



 Score = 37.0 bits (84), Expect = 0.082
 Identities = 42/173 (24%), Positives = 66/173 (38%), Gaps = 9/173 (5%)

Query: 133 PSTPAQVIAPSETPS--SSSVVKKRRKRRRKSQLDSLKR---DDNMNTSEDEDMFPIEMS 187
           P  P   + P+   S  +S  V K      K    + K+   D    T+  ++   IE +
Sbjct: 216 PINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKT 275

Query: 188 SDEAMELLESSRTLPNDIPPFQDDIPEENLSLAVI-YPQSASYPNSDREWSPTPSPSGSR 246
           S  A +L  +S+ L    P  +       L+      P +   P S     PTP+   S 
Sbjct: 276 S--AKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSA 333

Query: 247 PSTPKSDSELVSKSTERTGQKNPEMLWLWGELPQAAKSSSPHKMKESSPLSSR 299
           P+TPK  +   +KS   T  K P         P   K  +P   KE +P +++
Sbjct: 334 PTTPKEPAPTTTKSAPTT-PKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTK 385



 Score = 36.2 bits (82), Expect = 0.14
 Identities = 44/177 (24%), Positives = 65/177 (36%), Gaps = 33/177 (18%)

Query: 224 PQSASYPNSDREWSPTPS-PSGSRPSTPKSDSELVSKSTERTGQKNPEMLWLWGELPQAA 282
           P +   P S     P P+ P G+ P+TPK  +         T  K P         P   
Sbjct: 694 PTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAP--------TTPKEP--------APTTP 737

Query: 283 KSSSPHKMKESSPLSSRKICDKSHFQAIHSESSDTFSDQ-SPTLVGGALLDQNKPQTEMQ 341
           K ++P  +KE +P + +K   K          + T SD+ +PT            +T   
Sbjct: 738 KGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPT---------TPKETAPT 788

Query: 342 FVNEEDLETLGAAAPLLPMIEELKPPSASVVQTANKTDSPS---RKRDKRSRHLGAD 395
              E    T    AP  P   E  PP+ S V T   T  P+   +  D+ +  L A+
Sbjct: 789 TPKEPAPTTPKKPAPTTP---ETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAE 842



 Score = 34.3 bits (77), Expect = 0.53
 Identities = 20/72 (27%), Positives = 32/72 (44%), Gaps = 1/72 (1%)

Query: 230 PNSDREWSPTPSPSGSRPSTPKSDSELVSKSTERTGQKNPEMLWLWGELPQAAKSSSPHK 289
           P + +E +PT +P    P+TPK  +    K    T  K P         P   K  +P  
Sbjct: 513 PTTTKEPAPT-TPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTT 571

Query: 290 MKESSPLSSRKI 301
            KE++P + +K+
Sbjct: 572 PKETAPTTPKKL 583



 Score = 33.5 bits (75), Expect = 0.90
 Identities = 33/157 (21%), Positives = 57/157 (36%), Gaps = 8/157 (5%)

Query: 149 SSVVKKRRKRRRKSQLDSLKRDDNMNTSEDEDMFPIEMSSDEAMELLESSR-----TLPN 203
           ++   K+     K +  S K   ++  +  +D+ P      +     E++      T P 
Sbjct: 248 TTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPK 307

Query: 204 DIPPFQDDIPEENLSLAVIYPQSASYPNSDREWSPTPSPSGSRPSTPKSDSELVSKSTER 263
           +  P     P              S P + +E  P P+ + S P+TPK  +   +K    
Sbjct: 308 EPTPTTPKEPASTTPKEPTPTTIKSAPTTPKE--PAPTTTKSAPTTPKEPAPTTTKEPAP 365

Query: 264 TGQKNPEMLWLWGELPQAAKSSSPHKMKESSPLSSRK 300
           T  K P         P   K S+P   KE +P + +K
Sbjct: 366 TTPKEPAPTTTKEPAPTTTK-SAPTTPKEPAPTTPKK 401



 Score = 32.0 bits (71), Expect = 2.6
 Identities = 36/190 (18%), Positives = 67/190 (35%), Gaps = 22/190 (11%)

Query: 110 SEGASRMECQLKRGSVDRMRGLDPSTPAQVIAPSETPSSSSVVKKRRKRRRKSQLDSLKR 169
           ++G  +     +  S+++    D +  ++V+A   TP + +  K       K    +  +
Sbjct: 257 TDGKEKTTSAKETQSIEKTSAKDLAPTSKVLA-KPTPKAETTTKGPALTTPKEPTPTTPK 315

Query: 170 DDNMNTSEDEDMFPIEMS----SDEAMELLESSRTLPNDIPPFQDDIPEENLSLAVIYPQ 225
           +    T ++     I+ +     + A    +S+ T P +  P     P          P 
Sbjct: 316 EPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPA---------PT 366

Query: 226 SASYPNSDREWSPTPSPSGSRPSTPKSDSELVSKSTERTGQKNPEMLWLWGELPQAAKSS 285
           +   P       P P+ + S P+TPK  +    K    T  K P         P   K  
Sbjct: 367 TPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEP--------APTTPKEP 418

Query: 286 SPHKMKESSP 295
           +P   KE +P
Sbjct: 419 TPTTPKEPAP 428



 Score = 30.8 bits (68), Expect = 5.8
 Identities = 33/139 (23%), Positives = 51/139 (36%), Gaps = 19/139 (13%)

Query: 200 TLPNDIPPFQDDIPEENL--SLAVIYPQSASYPNSDREWSPTP-------SPSGSRPSTP 250
           T P  + P   + P       LA   P+  + P +  E +PT        +P    P+TP
Sbjct: 586 TTPEKLAPTTPEKPAPTTPEELAPTTPEEPT-PTTPEEPAPTTPKAAAPNTPKEPAPTTP 644

Query: 251 KSDSELVSKSTERTGQKNPEMLWLWGELPQAAKSSSPHKMKESSPLSSRKICDKSHFQAI 310
           K  +    K    T  K           P   K ++P  +KE +P + +K   K      
Sbjct: 645 KEPAPTTPKEPAPTTPKE--------TAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTT 696

Query: 311 HSESSDTFSDQ-SPTLVGG 328
             E + T  D+ +PT   G
Sbjct: 697 TKEPTSTTCDKPAPTTPKG 715


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 39.3 bits (90), Expect = 0.016
 Identities = 47/222 (21%), Positives = 79/222 (35%), Gaps = 13/222 (5%)

Query: 90  QETDNDQEVIPMHLA-TSPILSEGASRMECQLKRGSVDRMRGLDPSTPAQVIA------- 141
           +ET + ++     LA TS +L++   + E   K  ++   +   P+TP +  +       
Sbjct: 308 KETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPT 367

Query: 142 PSETPSSSSVVKKRRKRRRKSQLDSLKRDDNMNTSEDEDMFPIE----MSSDEAMELLES 197
           P+   S+ +  K+      KS   + K      T E     P E     + + A    +S
Sbjct: 368 PTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKS 427

Query: 198 SRTLPNDIPPFQDDIPEENLSLAVIYPQSASYPNSDREWSPTPSPSGSRPSTPKSDSELV 257
           + T P +  P     P          P +   P       P P+     P+TPK  +   
Sbjct: 428 APTTPKEPAPTTPKKPAPTTPKEPA-PTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTA 486

Query: 258 SKSTERTGQKNPEMLWLWGELPQAAKSSSPHKMKESSPLSSR 299
            K    T  K P         P   K  SP   KE +P +++
Sbjct: 487 PKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTK 528



 Score = 37.7 bits (86), Expect = 0.048
 Identities = 27/105 (25%), Positives = 41/105 (39%), Gaps = 2/105 (1%)

Query: 196 ESSRTLPNDIPPFQDDIPEENLSLAVIYPQSASYPNSDREWSPTPSPSGSRPSTPKSDSE 255
           E + T P +  P     P            + S P + +E  P P+ + S P+TPK  S 
Sbjct: 497 EPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKE--PAPTTTKSAPTTPKEPSP 554

Query: 256 LVSKSTERTGQKNPEMLWLWGELPQAAKSSSPHKMKESSPLSSRK 300
             +K    T  K P         P   K  +P   KE +P +++K
Sbjct: 555 TTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKK 599



 Score = 37.0 bits (84), Expect = 0.082
 Identities = 42/173 (24%), Positives = 66/173 (38%), Gaps = 9/173 (5%)

Query: 133 PSTPAQVIAPSETPS--SSSVVKKRRKRRRKSQLDSLKR---DDNMNTSEDEDMFPIEMS 187
           P  P   + P+   S  +S  V K      K    + K+   D    T+  ++   IE +
Sbjct: 257 PINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKT 316

Query: 188 SDEAMELLESSRTLPNDIPPFQDDIPEENLSLAVI-YPQSASYPNSDREWSPTPSPSGSR 246
           S  A +L  +S+ L    P  +       L+      P +   P S     PTP+   S 
Sbjct: 317 S--AKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSA 374

Query: 247 PSTPKSDSELVSKSTERTGQKNPEMLWLWGELPQAAKSSSPHKMKESSPLSSR 299
           P+TPK  +   +KS   T  K P         P   K  +P   KE +P +++
Sbjct: 375 PTTPKEPAPTTTKSAPTT-PKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTK 426



 Score = 36.2 bits (82), Expect = 0.14
 Identities = 44/177 (24%), Positives = 65/177 (36%), Gaps = 33/177 (18%)

Query: 224 PQSASYPNSDREWSPTPS-PSGSRPSTPKSDSELVSKSTERTGQKNPEMLWLWGELPQAA 282
           P +   P S     P P+ P G+ P+TPK  +         T  K P         P   
Sbjct: 735 PTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAP--------TTPKEP--------APTTP 778

Query: 283 KSSSPHKMKESSPLSSRKICDKSHFQAIHSESSDTFSDQ-SPTLVGGALLDQNKPQTEMQ 341
           K ++P  +KE +P + +K   K          + T SD+ +PT            +T   
Sbjct: 779 KGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPT---------TPKETAPT 829

Query: 342 FVNEEDLETLGAAAPLLPMIEELKPPSASVVQTANKTDSPS---RKRDKRSRHLGAD 395
              E    T    AP  P   E  PP+ S V T   T  P+   +  D+ +  L A+
Sbjct: 830 TPKEPAPTTPKKPAPTTP---ETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAE 883



 Score = 34.3 bits (77), Expect = 0.53
 Identities = 20/72 (27%), Positives = 32/72 (44%), Gaps = 1/72 (1%)

Query: 230 PNSDREWSPTPSPSGSRPSTPKSDSELVSKSTERTGQKNPEMLWLWGELPQAAKSSSPHK 289
           P + +E +PT +P    P+TPK  +    K    T  K P         P   K  +P  
Sbjct: 554 PTTTKEPAPT-TPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTT 612

Query: 290 MKESSPLSSRKI 301
            KE++P + +K+
Sbjct: 613 PKETAPTTPKKL 624



 Score = 33.5 bits (75), Expect = 0.90
 Identities = 33/157 (21%), Positives = 57/157 (36%), Gaps = 8/157 (5%)

Query: 149 SSVVKKRRKRRRKSQLDSLKRDDNMNTSEDEDMFPIEMSSDEAMELLESSR-----TLPN 203
           ++   K+     K +  S K   ++  +  +D+ P      +     E++      T P 
Sbjct: 289 TTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPK 348

Query: 204 DIPPFQDDIPEENLSLAVIYPQSASYPNSDREWSPTPSPSGSRPSTPKSDSELVSKSTER 263
           +  P     P              S P + +E  P P+ + S P+TPK  +   +K    
Sbjct: 349 EPTPTTPKEPASTTPKEPTPTTIKSAPTTPKE--PAPTTTKSAPTTPKEPAPTTTKEPAP 406

Query: 264 TGQKNPEMLWLWGELPQAAKSSSPHKMKESSPLSSRK 300
           T  K P         P   K S+P   KE +P + +K
Sbjct: 407 TTPKEPAPTTTKEPAPTTTK-SAPTTPKEPAPTTPKK 442



 Score = 32.0 bits (71), Expect = 2.6
 Identities = 36/190 (18%), Positives = 67/190 (35%), Gaps = 22/190 (11%)

Query: 110 SEGASRMECQLKRGSVDRMRGLDPSTPAQVIAPSETPSSSSVVKKRRKRRRKSQLDSLKR 169
           ++G  +     +  S+++    D +  ++V+A   TP + +  K       K    +  +
Sbjct: 298 TDGKEKTTSAKETQSIEKTSAKDLAPTSKVLA-KPTPKAETTTKGPALTTPKEPTPTTPK 356

Query: 170 DDNMNTSEDEDMFPIEMS----SDEAMELLESSRTLPNDIPPFQDDIPEENLSLAVIYPQ 225
           +    T ++     I+ +     + A    +S+ T P +  P     P          P 
Sbjct: 357 EPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPA---------PT 407

Query: 226 SASYPNSDREWSPTPSPSGSRPSTPKSDSELVSKSTERTGQKNPEMLWLWGELPQAAKSS 285
           +   P       P P+ + S P+TPK  +    K    T  K P         P   K  
Sbjct: 408 TPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEP--------APTTPKEP 459

Query: 286 SPHKMKESSP 295
           +P   KE +P
Sbjct: 460 TPTTPKEPAP 469



 Score = 30.8 bits (68), Expect = 5.8
 Identities = 33/139 (23%), Positives = 51/139 (36%), Gaps = 19/139 (13%)

Query: 200 TLPNDIPPFQDDIPEENL--SLAVIYPQSASYPNSDREWSPTP-------SPSGSRPSTP 250
           T P  + P   + P       LA   P+  + P +  E +PT        +P    P+TP
Sbjct: 627 TTPEKLAPTTPEKPAPTTPEELAPTTPEEPT-PTTPEEPAPTTPKAAAPNTPKEPAPTTP 685

Query: 251 KSDSELVSKSTERTGQKNPEMLWLWGELPQAAKSSSPHKMKESSPLSSRKICDKSHFQAI 310
           K  +    K    T  K           P   K ++P  +KE +P + +K   K      
Sbjct: 686 KEPAPTTPKEPAPTTPKE--------TAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTT 737

Query: 311 HSESSDTFSDQ-SPTLVGG 328
             E + T  D+ +PT   G
Sbjct: 738 TKEPTSTTCDKPAPTTPKG 756


>gi|38788333 remodeling and spacing factor 1 [Homo sapiens]
          Length = 1441

 Score = 38.9 bits (89), Expect = 0.021
 Identities = 36/134 (26%), Positives = 53/134 (39%), Gaps = 4/134 (2%)

Query: 129  RGLDPSTPAQVIAPSETPSSSSVVKKRRKRRRKSQLDSLKRDDNMNTSEDEDMFPIEMSS 188
            RG D ST              +   +R+KRRR + LDS   D N++  E ED F I   S
Sbjct: 1059 RGKDISTILDEERKENKRPQRAAAARRKKRRRLNDLDS---DSNLDEEESEDEFKISDGS 1115

Query: 189  DEAMELLESSRTLPNDIPPFQDDIPEENLSLAVIYPQSASYPNSDREWSPTPSPSGSRPS 248
             +   + + +     + PP  DD   +  S  +    S     S R    TP    S   
Sbjct: 1116 QDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRRKTPKKKYS-DD 1174

Query: 249  TPKSDSELVSKSTE 262
              + +SE  S+ +E
Sbjct: 1175 DEEEESEENSRDSE 1188


>gi|117553580 adaptor-related protein complex 3, delta 1 subunit
           isoform 2 [Homo sapiens]
          Length = 1153

 Score = 38.9 bits (89), Expect = 0.021
 Identities = 37/154 (24%), Positives = 61/154 (39%), Gaps = 18/154 (11%)

Query: 154 KRRKRRRKSQLDSLKRDDNMNTSEDEDMFPIEMSSDEAMELLESSRTLPNDIPPFQDDIP 213
           KRRK+R++ +    +R  ++ T  DED+ P +       E+ E++  LP+D      + P
Sbjct: 741 KRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENA--LPSDEDDKDPNDP 798

Query: 214 EENLSLAVIYPQSASYPNSDREWSPTPSPSGSRPS-TPKSDSELVSKSTERTGQKNPEML 272
              L +          P +D E  P      +  S +P+ D  +V K +++  +K     
Sbjct: 799 YRALDI------DLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKK----- 847

Query: 273 WLWGELPQAAKSSSPHKMKESSPLSSRKICDKSH 306
               E     K     K KE     S K   K H
Sbjct: 848 ----EKKHKEKERDKEKKKEKEKKKSPKPKKKKH 877


>gi|169213985 PREDICTED: similar to hCG2036794 [Homo sapiens]
          Length = 518

 Score = 38.9 bits (89), Expect = 0.021
 Identities = 35/124 (28%), Positives = 57/124 (45%), Gaps = 19/124 (15%)

Query: 211 DIPEENLSLAVIYPQSASYPNSDREWSP------TPSPSGSRPSTPKSDSELVSKSTERT 264
           D+P+ NLS  + +P+S+  P       P      TP P+ S+ S P+      +   + T
Sbjct: 119 DMPKTNLS-KMAHPESSETPTPGPTEMPHPGSPETPKPNFSKTSRPEFPETPNTDLMQTT 177

Query: 265 GQKNPEMLWL------WGELPQAA-----KSSSPHKMKESSPLSSRKICDKSHFQAIHSE 313
            Q++PE+L L        ELP+ +     K+  P K  E   L+S +  +    QA+H +
Sbjct: 178 PQESPEILQLNATEVSQAELPETSNTNPTKTPDP-KSPEKHDLNSTETPNSEFLQALHPD 236

Query: 314 SSDT 317
            S T
Sbjct: 237 PSKT 240


>gi|239751846 PREDICTED: similar to hCG2036794 [Homo sapiens]
          Length = 518

 Score = 38.9 bits (89), Expect = 0.021
 Identities = 35/124 (28%), Positives = 57/124 (45%), Gaps = 19/124 (15%)

Query: 211 DIPEENLSLAVIYPQSASYPNSDREWSP------TPSPSGSRPSTPKSDSELVSKSTERT 264
           D+P+ NLS  + +P+S+  P       P      TP P+ S+ S P+      +   + T
Sbjct: 119 DMPKTNLS-KMAHPESSETPTPGPTEMPHPGSPETPKPNFSKTSRPEFPETPNTDLMQTT 177

Query: 265 GQKNPEMLWL------WGELPQAA-----KSSSPHKMKESSPLSSRKICDKSHFQAIHSE 313
            Q++PE+L L        ELP+ +     K+  P K  E   L+S +  +    QA+H +
Sbjct: 178 PQESPEILQLNATEVSQAELPETSNTNPTKTPDP-KSPEKHDLNSTETPNSEFLQALHPD 236

Query: 314 SSDT 317
            S T
Sbjct: 237 PSKT 240


>gi|239746337 PREDICTED: similar to hCG2036794 [Homo sapiens]
          Length = 518

 Score = 38.9 bits (89), Expect = 0.021
 Identities = 35/124 (28%), Positives = 57/124 (45%), Gaps = 19/124 (15%)

Query: 211 DIPEENLSLAVIYPQSASYPNSDREWSP------TPSPSGSRPSTPKSDSELVSKSTERT 264
           D+P+ NLS  + +P+S+  P       P      TP P+ S+ S P+      +   + T
Sbjct: 119 DMPKTNLS-KMAHPESSETPTPGPTEMPHPGSPETPKPNFSKTSRPEFPETPNTDLMQTT 177

Query: 265 GQKNPEMLWL------WGELPQAA-----KSSSPHKMKESSPLSSRKICDKSHFQAIHSE 313
            Q++PE+L L        ELP+ +     K+  P K  E   L+S +  +    QA+H +
Sbjct: 178 PQESPEILQLNATEVSQAELPETSNTNPTKTPDP-KSPEKHDLNSTETPNSEFLQALHPD 236

Query: 314 SSDT 317
            S T
Sbjct: 237 PSKT 240


>gi|150378543 MYST histone acetyltransferase (monocytic leukemia) 3
            [Homo sapiens]
          Length = 2004

 Score = 38.1 bits (87), Expect = 0.037
 Identities = 46/196 (23%), Positives = 77/196 (39%), Gaps = 11/196 (5%)

Query: 109  LSEGASRMECQLKRGSVDRMRGLDPSTPAQVIAPSETPSSSSVVKKRRKRRRKSQLDS-- 166
            L+EG+ R+  +   G    +RG   S+  +    S   SS  ++ K   +R+K  L    
Sbjct: 962  LTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRKKPFLHRRR 1021

Query: 167  --LKRDDNMNTSEDEDMFPIEMSSDEAMELLESSRTLPNDIPPFQDDIPEENLSLAVIYP 224
               KR  + ++   E +       DE  E  +S R +P   P F+ D  EE      ++P
Sbjct: 1022 RVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELFP 1081

Query: 225  QSASYPNSDREWSPTPSPSGSRPSTPKSDSELVSKSTERTGQKNPEMLWLWGELPQAAKS 284
            +      S ++     S S  +    + D E  S   + T    P  L     L +    
Sbjct: 1082 REYFRRLSSQDVLRCQSSSKRKSKDEEEDEE--SDDADDTPILKPVSL-----LRKRDVK 1134

Query: 285  SSPHKMKESSPLSSRK 300
            +SP +   S+PL  +K
Sbjct: 1135 NSPLEPDTSTPLKKKK 1150


>gi|150378463 MYST histone acetyltransferase (monocytic leukemia) 3
            [Homo sapiens]
          Length = 2004

 Score = 38.1 bits (87), Expect = 0.037
 Identities = 46/196 (23%), Positives = 77/196 (39%), Gaps = 11/196 (5%)

Query: 109  LSEGASRMECQLKRGSVDRMRGLDPSTPAQVIAPSETPSSSSVVKKRRKRRRKSQLDS-- 166
            L+EG+ R+  +   G    +RG   S+  +    S   SS  ++ K   +R+K  L    
Sbjct: 962  LTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRKKPFLHRRR 1021

Query: 167  --LKRDDNMNTSEDEDMFPIEMSSDEAMELLESSRTLPNDIPPFQDDIPEENLSLAVIYP 224
               KR  + ++   E +       DE  E  +S R +P   P F+ D  EE      ++P
Sbjct: 1022 RVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELFP 1081

Query: 225  QSASYPNSDREWSPTPSPSGSRPSTPKSDSELVSKSTERTGQKNPEMLWLWGELPQAAKS 284
            +      S ++     S S  +    + D E  S   + T    P  L     L +    
Sbjct: 1082 REYFRRLSSQDVLRCQSSSKRKSKDEEEDEE--SDDADDTPILKPVSL-----LRKRDVK 1134

Query: 285  SSPHKMKESSPLSSRK 300
            +SP +   S+PL  +K
Sbjct: 1135 NSPLEPDTSTPLKKKK 1150


>gi|150378493 MYST histone acetyltransferase (monocytic leukemia) 3
            [Homo sapiens]
          Length = 2004

 Score = 38.1 bits (87), Expect = 0.037
 Identities = 46/196 (23%), Positives = 77/196 (39%), Gaps = 11/196 (5%)

Query: 109  LSEGASRMECQLKRGSVDRMRGLDPSTPAQVIAPSETPSSSSVVKKRRKRRRKSQLDS-- 166
            L+EG+ R+  +   G    +RG   S+  +    S   SS  ++ K   +R+K  L    
Sbjct: 962  LTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRKKPFLHRRR 1021

Query: 167  --LKRDDNMNTSEDEDMFPIEMSSDEAMELLESSRTLPNDIPPFQDDIPEENLSLAVIYP 224
               KR  + ++   E +       DE  E  +S R +P   P F+ D  EE      ++P
Sbjct: 1022 RVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELFP 1081

Query: 225  QSASYPNSDREWSPTPSPSGSRPSTPKSDSELVSKSTERTGQKNPEMLWLWGELPQAAKS 284
            +      S ++     S S  +    + D E  S   + T    P  L     L +    
Sbjct: 1082 REYFRRLSSQDVLRCQSSSKRKSKDEEEDEE--SDDADDTPILKPVSL-----LRKRDVK 1134

Query: 285  SSPHKMKESSPLSSRK 300
            +SP +   S+PL  +K
Sbjct: 1135 NSPLEPDTSTPLKKKK 1150


>gi|117553584 adaptor-related protein complex 3, delta 1 subunit
           isoform 1 [Homo sapiens]
          Length = 1112

 Score = 37.7 bits (86), Expect = 0.048
 Identities = 43/184 (23%), Positives = 72/184 (39%), Gaps = 25/184 (13%)

Query: 154 KRRKRRRKSQLDSLKRDDNMNTSEDEDMFPIEMSSDEAMELLESSRTLPNDIPPFQDDIP 213
           KRRK+R++ +    +R  ++ T  DED+ P +       E+ E++  LP+D      + P
Sbjct: 650 KRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENA--LPSDEDDKDPNDP 707

Query: 214 EENLSLAVIYPQSAS-------YPNSDREWSPTPS-PSGSRPSTPKSDSELVSKSTERTG 265
              L + +  P + S       + N++   SP    P   + S      E   K  ER  
Sbjct: 708 YRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDK 767

Query: 266 QKNPEM--------LWLWGELPQAAKSSSPHKMKESSPLSSRKICDKSHFQAIHSESSDT 317
           +K  E          WL    P  A + +P      +P+ S   C+ +  +A   E    
Sbjct: 768 EKKKEKEKKAEDLDFWL-STTPPPAPAPAP------APVPSTDECEDAKTEAQGEEDDAE 820

Query: 318 FSDQ 321
             DQ
Sbjct: 821 GQDQ 824


>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
           [Homo sapiens]
          Length = 918

 Score = 37.7 bits (86), Expect = 0.048
 Identities = 61/253 (24%), Positives = 90/253 (35%), Gaps = 31/253 (12%)

Query: 129 RGLDPSTPAQVIAPSETPSSSSVVKKRRKRRRKSQLDSLKRDDNMNTSEDEDMFPIEMSS 188
           R L P TPA   AP+     +S  +   K+ +   L+S+     M T +D     +    
Sbjct: 194 RTLSP-TPASATAPTSQGIPTSDEESTPKKSKARILESITVSSLMATPQDPKGQGVGTGR 252

Query: 189 DEAMELLESSRTLPNDIPPFQDDIPEENLSLAVIYPQSASYPNSDREWSPTPSPSGSRPS 248
             +   +      P D P F D  P     LA I P + S P   R  S +   S   PS
Sbjct: 253 SASKLRIAQVSPGPRDSPAFPDS-PWRERVLAPILPDNFSTPTGSRTDSQSVRHSPIAPS 311

Query: 249 TPKSDSELVSKSTERTGQKNPEMLWLWGELPQAAKSSSPHKMKESSPLSSRKICDKSHFQ 308
           +P S   L  K +    Q++         + + A      K  E    S R IC      
Sbjct: 312 SP-SPQVLAQKYSLVAKQES---------VVRRASRRLAKKTAEEPAASGRIIC------ 355

Query: 309 AIHSESSDTFSDQSPTLVGGALLDQNKPQTEMQFVNEEDLETLGAAAPLLPMIEELKPPS 368
             HS      + + P  VG    +Q +P         E+ E + AA P +P         
Sbjct: 356 --HSYLERLLNVEVPQKVGS---EQKEP--------PEEAEPVAAAEPEVPENNGNNSWP 402

Query: 369 ASVVQTANKTDSP 381
            +  + AN T +P
Sbjct: 403 HNDTEIANSTPNP 415



 Score = 33.9 bits (76), Expect = 0.69
 Identities = 27/102 (26%), Positives = 46/102 (45%), Gaps = 19/102 (18%)

Query: 201 LPNDIPPFQDDIPEENLSLAVIYPQ------SASYPNSDREWS---PTPSPSGSRPSTPK 251
           +P  +   Q + PEE   +A   P+      + S+P++D E +   P P P+ S P TP 
Sbjct: 367 VPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETP- 425

Query: 252 SDSELVSKSTERTGQKNPEMLWLWGELPQAAKSSSPHKMKES 293
           S  +  +K+ +  G + P         PQ+A+    +K   S
Sbjct: 426 SAGQQEAKTDQADGPREP---------PQSARRKRSYKQAVS 458


>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
           [Homo sapiens]
          Length = 914

 Score = 37.7 bits (86), Expect = 0.048
 Identities = 61/253 (24%), Positives = 90/253 (35%), Gaps = 31/253 (12%)

Query: 129 RGLDPSTPAQVIAPSETPSSSSVVKKRRKRRRKSQLDSLKRDDNMNTSEDEDMFPIEMSS 188
           R L P TPA   AP+     +S  +   K+ +   L+S+     M T +D     +    
Sbjct: 194 RTLSP-TPASATAPTSQGIPTSDEESTPKKSKARILESITVSSLMATPQDPKGQGVGTGR 252

Query: 189 DEAMELLESSRTLPNDIPPFQDDIPEENLSLAVIYPQSASYPNSDREWSPTPSPSGSRPS 248
             +   +      P D P F D  P     LA I P + S P   R  S +   S   PS
Sbjct: 253 SASKLRIAQVSPGPRDSPAFPDS-PWRERVLAPILPDNFSTPTGSRTDSQSVRHSPIAPS 311

Query: 249 TPKSDSELVSKSTERTGQKNPEMLWLWGELPQAAKSSSPHKMKESSPLSSRKICDKSHFQ 308
           +P S   L  K +    Q++         + + A      K  E    S R IC      
Sbjct: 312 SP-SPQVLAQKYSLVAKQES---------VVRRASRRLAKKTAEEPAASGRIIC------ 355

Query: 309 AIHSESSDTFSDQSPTLVGGALLDQNKPQTEMQFVNEEDLETLGAAAPLLPMIEELKPPS 368
             HS      + + P  VG    +Q +P         E+ E + AA P +P         
Sbjct: 356 --HSYLERLLNVEVPQKVGS---EQKEP--------PEEAEPVAAAEPEVPENNGNNSWP 402

Query: 369 ASVVQTANKTDSP 381
            +  + AN T +P
Sbjct: 403 HNDTEIANSTPNP 415



 Score = 33.9 bits (76), Expect = 0.69
 Identities = 27/102 (26%), Positives = 46/102 (45%), Gaps = 19/102 (18%)

Query: 201 LPNDIPPFQDDIPEENLSLAVIYPQ------SASYPNSDREWS---PTPSPSGSRPSTPK 251
           +P  +   Q + PEE   +A   P+      + S+P++D E +   P P P+ S P TP 
Sbjct: 367 VPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETP- 425

Query: 252 SDSELVSKSTERTGQKNPEMLWLWGELPQAAKSSSPHKMKES 293
           S  +  +K+ +  G + P         PQ+A+    +K   S
Sbjct: 426 SAGQQEAKTDQADGPREP---------PQSARRKRSYKQAVS 458


>gi|7662238 apoptotic chromatin condensation inducer 1 [Homo
           sapiens]
          Length = 1341

 Score = 37.4 bits (85), Expect = 0.062
 Identities = 52/239 (21%), Positives = 94/239 (39%), Gaps = 29/239 (12%)

Query: 134 STPAQVIAPSETPSSSSVVKKRRKRRRKSQLDSLKRDDNMNTSEDEDMFPIEMSSDEA-- 191
           S PA+     ETPS +  ++ R  R  K++ +  + ++     E+E+       S EA  
Sbjct: 243 SQPAEEEEDQETPSRN--LRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPI 300

Query: 192 -MELLESSRTLPNDIP-PFQDDIPEENLSLAVIYPQSASYPNSDREWSPTPSPSGSRPST 249
             E  E    +P   P    D+ P+       +  +   +  S  E          +   
Sbjct: 301 LKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEE--------ARKSHL 352

Query: 250 PKSDSELVSKSTERTGQKNPEMLWLWGELPQAAKSSSPHKMKESSPLSSRKICDKSHFQA 309
            +   E   K+T    ++  E+    G L + +KS SP ++ E      RK   K+   A
Sbjct: 353 ARQQQEKEMKTTSPLEEEEREIKSSQG-LKEKSKSPSPPRLTE-----DRK---KASLVA 403

Query: 310 IHSESSDTFSDQSPTLVGGALLDQNKPQTEMQFVNEEDLETLGAAAPLLPMIEELKPPS 368
           +  +++       P L   A    + P    Q  +EE++E +   AP  P++ +L PP+
Sbjct: 404 LPEQTASEEETPPPLLTKEA----SSPPPHPQLHSEEEIEPMEGPAP--PVLIQLSPPN 456


>gi|162287219 prune homolog 2 [Homo sapiens]
          Length = 3088

 Score = 37.0 bits (84), Expect = 0.082
 Identities = 60/253 (23%), Positives = 92/253 (36%), Gaps = 26/253 (10%)

Query: 162  SQLDSLKRDDNMNTSEDEDMFPIEMSSDEAMELLESSRTLPNDIPPF------QDDIPEE 215
            S +D     DN +     D+ P   +S E  EL E  +T+P   P        ++   E+
Sbjct: 2481 SNVDWEVETDNSDLPAGGDIGPPNGASKEISEL-EEEKTIPTKEPEQIKSEYKEERCTEK 2539

Query: 216  NLSLAVIYPQSASYPNSDREWSPTPSPSGSRPSTPKSDSELVSKSTERTGQKNPEMLWLW 275
            N     ++       N +      P     R S  + +  + SK T   G          
Sbjct: 2540 NEDRHALH-MDYILVNREENSHSKPETCEERESIAELELYVGSKETGLQGT--------- 2589

Query: 276  GELPQAAKSSSPHKMKESSPLSSRKICDKSH----FQAIHSESSDTFSDQSPTLVGGALL 331
             +L     +  P  + E   LS+ K+  KS     F++   + S  F   S   VG   L
Sbjct: 2590 -QLASFPDTCQPASLNERKGLSAEKMSSKSDTRSSFESPAQDQSWMFLGHSE--VGDPSL 2646

Query: 332  DQNKPQTEMQFVNEEDLETLGAA-APLLPMIEELKPPSASVVQTANKTDSPSRKRDKRSR 390
            D             E    LG    P L ++EE+KP  +  ++ A+   S S+K   R R
Sbjct: 2647 DARDSGPGWSGKTVEPFSELGLGEGPQLQILEEMKPLESLALEEASGPVSQSQKSKSRGR 2706

Query: 391  HLGADGVYLDDLT 403
              G D V L  +T
Sbjct: 2707 -AGPDAVTLQAVT 2718


>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
          Length = 1301

 Score = 37.0 bits (84), Expect = 0.082
 Identities = 64/325 (19%), Positives = 110/325 (33%), Gaps = 23/325 (7%)

Query: 132  DPSTPAQVIAPSETPSSSSVVKKRRKRRRKSQLDSLKRDDNMNTSEDEDMFPIEMSSDEA 191
            D S  +     S++ +SS            +  DS    D+ N+S+  D      SSD +
Sbjct: 987  DSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSS 1046

Query: 192  MELLESSRTLPNDIPPFQDDIPEENLSLAVIYPQSASYPNSDREWSPTPSPSGSRPSTPK 251
                 S  +  +D     D     + S        +S  +   E S +   S S  S+  
Sbjct: 1047 DSSDSSDSSNSSDSSDSSDSSDSSDSS-------DSSDSSDSSESSDSSDSSNSSDSSDS 1099

Query: 252  SDSELVSKSTERTGQKNPEMLWLWGELPQAAKSSSPHKMKESSPLSSRKICDKSHFQAIH 311
            SDS   S S++ +   +            ++ SS+     +SS  S       S   +  
Sbjct: 1100 SDSSDSSDSSDSSDSSD------------SSDSSNSSDSSDSSDSSDSSDSSNSSDSSDS 1147

Query: 312  SESSDTFSDQSPTLVGGALLDQNKPQTEMQFVNEEDLETLGAAAPLLPMIEELKPPSASV 371
            SESSD+ SD S +       D +         N  D      ++      +      +S 
Sbjct: 1148 SESSDS-SDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSD 1206

Query: 372  VQTANKTDSPSRKRDKRSRHLGADGVYLDDLTDMDPEVAALYFPKNGDPSGLAKHASDNG 431
               ++ +   S   D       +D     D +D      +     + D S  +   SD+ 
Sbjct: 1207 SSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSN 1266

Query: 432  ARSANQSPQSVGSSGVDSGVESTSD 456
              S +QS      +G ++G +S SD
Sbjct: 1267 DESDSQSK---SGNGNNNGSDSDSD 1288



 Score = 35.4 bits (80), Expect = 0.24
 Identities = 59/297 (19%), Positives = 106/297 (35%), Gaps = 22/297 (7%)

Query: 165  DSLKRDDNMNTSEDEDMFPIEMSSDEAMELLESSRTLPNDIPPFQDDIPEENLSLAVIYP 224
            DS    D+ N+S+  D      SSD +     S+ +  +D     D     +   +    
Sbjct: 772  DSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSD 831

Query: 225  QSASYPNSDREWSPTPSPSGSRPSTPKSDSELVSKSTERTGQKNPEMLWLWGELPQAAKS 284
             S S  +SD   S   S      S+ +SDS   S S++ +   N        +   ++ S
Sbjct: 832  SSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNS------SDSSDSSDS 885

Query: 285  SSPHKMKESSPLSSRKICDKSHFQAIHSESSDTFSDQSPTLVGGALLDQNKPQTEMQFVN 344
            +      +SS  S+    D S   +  S+SSD+ +    +    +  + N   +     +
Sbjct: 886  NESSNSSDSSDSSNSSDSDSSD-SSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDS 944

Query: 345  EEDLETLGAAAPLLPMIEELKPPSASVVQTANKTD-SPSRKRDKRSRHLGADGVYLDDLT 403
             +  ++  ++             S++   ++N +D S S   D       +D     D +
Sbjct: 945  SDSSDSSNSS------------DSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSS 992

Query: 404  DMDPEVAALYFPKNGDPSGLAKHASDNGARSANQSPQSVGSSGVDSGVESTSDGLRD 460
            D      +     + D S  +   S N + S+N S  S  S   DS   S S    D
Sbjct: 993  DSSDSSDSSNSSDSSDSSDSSD--SSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSD 1047



 Score = 34.7 bits (78), Expect = 0.40
 Identities = 71/349 (20%), Positives = 123/349 (35%), Gaps = 18/349 (5%)

Query: 110 SEGASRMECQLKRGSVDRMRGLDPSTPAQVIAPSETPSSSSVVKKRRKRRRKSQLDSLKR 169
           S+ ++  +      S D     D S      + SE+ SS S  K        S  +S   
Sbjct: 596 SDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSD-----SSDSNSSDS 650

Query: 170 DDNMNTSEDEDMFPIEMSSDEAMELLESSRTLPNDIPPFQDDIPEENLSLAVIYPQSASY 229
            DN ++S+  +      SSD +     SS +  ++     D     N S +     S+  
Sbjct: 651 SDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDS 710

Query: 230 PNSDREWS--PTPSPSGSRPSTPKSDSELVSKSTERTGQKNPEMLWLWGELPQAAKSSSP 287
            +SD   S     S S S  S+  SDS   S S++ +   N        +   ++ SS  
Sbjct: 711 DSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDS---SDSSDSSNSSDS 767

Query: 288 HKMKESSPLSSRKICDKSHFQAIHSESSDTFSDQSPTLVGGALLDQNKPQTEMQFVNEED 347
               +SS  S       S+  +  S+SSD  S  S      +    +   ++    N  D
Sbjct: 768 SDSSDSSDSSDSSNSSDSNDSSNSSDSSD--SSNSSDSSNSSDSSDSSDSSDSDSSNSSD 825

Query: 348 LETLGAAAPLLPMIEELKPPSASVVQTANKTDSPSRKR-DKRSRHLGADGVYLDDLTDMD 406
                 ++            S+    +++ +DS S  R D  +    +D     + +D  
Sbjct: 826 SSNSSDSSD-----SSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSS 880

Query: 407 PEVAALYFPKNGDPSGLAKHASDNGARSANQSPQSVGSSGVDSGVESTS 455
               +     + D S  +  +  + + S+N S  S  S+  DS   S S
Sbjct: 881 DSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNS 929



 Score = 34.3 bits (77), Expect = 0.53
 Identities = 44/199 (22%), Positives = 71/199 (35%), Gaps = 4/199 (2%)

Query: 124  SVDRMRGLDPSTPAQVIAPSETPSSSSVVKKRRKRRRKSQLDSLKRDDNMNTSEDEDMFP 183
            S D     D S  +     S +  SS               DS    D+ N+S+  D   
Sbjct: 1072 SSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSD 1131

Query: 184  IEMSSDEAMELLESSRTLPNDIPPFQDDIPEENLSLAVIYPQSASYPNSDREWSPTPSPS 243
               SSD +     S  +  +D     D     + S +     S+   NS    S +   S
Sbjct: 1132 SSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNS----SDSSDSS 1187

Query: 244  GSRPSTPKSDSELVSKSTERTGQKNPEMLWLWGELPQAAKSSSPHKMKESSPLSSRKICD 303
             S  S+  SDS   S S++ +   +        +   ++ SS  ++  +SS  S      
Sbjct: 1188 DSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSS 1247

Query: 304  KSHFQAIHSESSDTFSDQS 322
             S   +  S+SSD+ SD +
Sbjct: 1248 NSSDSSDSSDSSDSTSDSN 1266



 Score = 31.2 bits (69), Expect = 4.5
 Identities = 50/214 (23%), Positives = 76/214 (35%), Gaps = 13/214 (6%)

Query: 110  SEGASRMECQLKRGSVDRMRGLDPSTPAQVIAPSETPSSSSVVKKRRKRRRKSQLDSLKR 169
            S+ +   +      S D     D S  +     S++ +SS               DS   
Sbjct: 992  SDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDS 1051

Query: 170  DDNMNTSEDEDMFPIEMSSDEAMELLESSRTLPNDIPPFQDDIPEENLSLAVIYPQSASY 229
             D+ N+S+  D      SSD +     S  +  +D     D     N S       S S 
Sbjct: 1052 SDSSNSSDSSD------SSDSSDSSDSSDSSDSSDSSESSDSSDSSNSS-----DSSDSS 1100

Query: 230  PNSD-REWSPTPSPSGSRPSTPKSDSELVSKSTERTGQKNPEMLWLWGELPQAAKSSSPH 288
             +SD  + S +   S S  S+  SDS   S S++ +   N        E   ++ SS   
Sbjct: 1101 DSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSS 1160

Query: 289  KMKESSPLSSRKICDKSHFQAIHSESSDTFSDQS 322
               +SS  S       S   +  S+SSD+ SD S
Sbjct: 1161 DSSDSSDSSDSSDSSDSSNSSDSSDSSDS-SDSS 1193


>gi|197313748 SET domain containing 2 [Homo sapiens]
          Length = 2564

 Score = 36.2 bits (82), Expect = 0.14
 Identities = 60/231 (25%), Positives = 92/231 (39%), Gaps = 27/231 (11%)

Query: 107  PILSEGASRMECQLKRGSVDRMRGLDPSTPAQVIAPSETPSSSSVVKKRRKRRRKSQLDS 166
            P LSEG         R     +   DPST     A ++TP    ++ +R K   ++ +DS
Sbjct: 1835 PPLSEGDGYSSENTSRAHTP-LNTPDPSTKLSTEADTDTPKK--LMFRRLKIISENSMDS 1891

Query: 167  LKRDDNMNTSE------DEDMFPIEMSSDEAMELLESSRTLPNDIPPFQDDIPEENLSLA 220
               D    TSE       ED+  +E    E  E L+S + LP  +P  + D  E N+  +
Sbjct: 1892 AISDA---TSELEGKDGKEDLDQLENVPVEEEEELQSQQLLPQQLPECKVD-SETNIEAS 1947

Query: 221  VIYPQSASYPNSDREWSPTPSPSGSR------PSTPKSDSEL-VSKSTERTGQKNPEMLW 273
             +     S P +D E  P  S +G++        TP  D E  VS       Q+ P+   
Sbjct: 1948 KL---PTSEPEADAEIEPKES-NGTKLEEPINEETPSQDEEEGVSDVESERSQEQPDKTV 2003

Query: 274  LWGELPQAAKSSSPHK-MKESSPLSSRKICDKSHFQAIHSESSDTFSDQSP 323
               +L  A K     K +KE   +  +   +K +        +  F DQ+P
Sbjct: 2004 DISDL--ATKLLDSWKDLKEVYRIPKKSQTEKENTTTERGRDAVGFRDQTP 2052


>gi|224549005 RNA binding motif protein 17 [Homo sapiens]
          Length = 401

 Score = 35.8 bits (81), Expect = 0.18
 Identities = 31/98 (31%), Positives = 43/98 (43%), Gaps = 8/98 (8%)

Query: 153 KKRRKRRRKSQLDSLKRDDNMNTSEDEDMFPIEMSSDEAM-----ELLESSRTLPNDIPP 207
           +KRRK R ++   + + D + +  ED +    + S   A       L+E  + LP D P 
Sbjct: 135 EKRRKDRHEASGFARRPDPDSDEDEDYERERRKRSMGGAAIAPPTSLVEKDKELPRDFPY 194

Query: 208 FQDDIPEENLSLAVIYPQSASYPNSDREWSPTPSPSGS 245
            +D  P    S A I P    Y   DR  SPT  PS S
Sbjct: 195 EEDSRPRSQSSKAAIPP--PVYEEQDRPRSPT-GPSNS 229


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.130    0.384 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,514,185
Number of Sequences: 37866
Number of extensions: 1778119
Number of successful extensions: 6128
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 18
Number of HSP's successfully gapped in prelim test: 154
Number of HSP's that attempted gapping in prelim test: 5808
Number of HSP's gapped (non-prelim): 402
length of query: 890
length of database: 18,247,518
effective HSP length: 111
effective length of query: 779
effective length of database: 14,044,392
effective search space: 10940581368
effective search space used: 10940581368
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.