Guide to the Human Genome
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Search of human proteins with 21956641

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21956641 ISL LIM homeobox 2 [Homo sapiens]
         (359 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21956641 ISL LIM homeobox 2 [Homo sapiens]                         740   0.0  
gi|115387114 islet-1 [Homo sapiens]                                   551   e-157
gi|33569216 LIM homeobox 9 isoform 1 [Homo sapiens]                   181   7e-46
gi|62241033 LIM homeobox 9 isoform 2 [Homo sapiens]                   181   7e-46
gi|30795196 LIM homeobox protein 2 [Homo sapiens]                     177   1e-44
gi|4505007 LIM homeobox transcription factor 1, beta [Homo sapiens]   177   2e-44
gi|28893581 LIM homeobox transcription factor 1, alpha isoform a...   175   6e-44
gi|30023847 LIM homeobox protein 3 isoform a [Homo sapiens]           164   1e-40
gi|7657303 LIM homeobox protein 3 isoform b [Homo sapiens]            164   1e-40
gi|30410785 LIM homeobox protein 1 [Homo sapiens]                     164   1e-40
gi|11641283 LIM homeobox protein 5 [Homo sapiens]                     161   7e-40
gi|15375314 LIM homeobox protein 4 [Homo sapiens]                     160   2e-39
gi|50083287 LIM homeobox 8 [Homo sapiens]                             159   5e-39
gi|134284361 LIM homeobox protein 6 isoform 2 [Homo sapiens]          158   8e-39
gi|134284359 LIM homeobox protein 6 isoform 1 [Homo sapiens]          158   8e-39
gi|5803072 LIM domain only 4 [Homo sapiens]                           112   4e-25
gi|21361802 LIM domain only 3 [Homo sapiens]                          107   2e-23
gi|47778935 LIM domain only 3 [Homo sapiens]                          107   2e-23
gi|4505005 LIM domain only 1 [Homo sapiens]                           105   5e-23
gi|214832219 LIM domain only 2 isoform 2 [Homo sapiens]                92   5e-19
gi|214832121 LIM domain only 2 isoform 2 [Homo sapiens]                92   5e-19
gi|214832074 LIM domain only 2 isoform 1 [Homo sapiens]                92   5e-19
gi|4505001 LIM domain kinase 1 [Homo sapiens]                          81   1e-15
gi|51173715 actin-binding LIM protein 1 isoform c [Homo sapiens]       81   2e-15
gi|51173713 actin-binding LIM protein 1 isoform b [Homo sapiens]       81   2e-15
gi|51173711 actin-binding LIM protein 1 isoform a [Homo sapiens]       81   2e-15
gi|7662330 actin binding LIM protein family, member 3 [Homo sapi...    75   9e-14
gi|5031869 LIM domain kinase 2 isoform 2a [Homo sapiens]               72   6e-13
gi|194272207 actin binding LIM protein family, member 2 isoform ...    71   1e-12
gi|153792514 actin binding LIM protein family, member 2 isoform ...    71   1e-12

>gi|21956641 ISL LIM homeobox 2 [Homo sapiens]
          Length = 359

 Score =  740 bits (1911), Expect = 0.0
 Identities = 359/359 (100%), Positives = 359/359 (100%)

Query: 1   MVDIIFHYPFLGAMGDHSKKKPGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQ 60
           MVDIIFHYPFLGAMGDHSKKKPGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQ
Sbjct: 1   MVDIIFHYPFLGAMGDHSKKKPGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQ 60

Query: 61  YLDETCTCFVRDGKTYCKRDYVRLFGIKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVC 120
           YLDETCTCFVRDGKTYCKRDYVRLFGIKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVC
Sbjct: 61  YLDETCTCFVRDGKTYCKRDYVRLFGIKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVC 120

Query: 121 SRQLLPGDEFSLREHELLCRADHGLLLERAAAGSPRSPGPLPGARGLHLPDAGSGRQPAL 180
           SRQLLPGDEFSLREHELLCRADHGLLLERAAAGSPRSPGPLPGARGLHLPDAGSGRQPAL
Sbjct: 121 SRQLLPGDEFSLREHELLCRADHGLLLERAAAGSPRSPGPLPGARGLHLPDAGSGRQPAL 180

Query: 181 RPHVHKQTEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQ 240
           RPHVHKQTEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQ
Sbjct: 181 RPHVHKQTEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQ 240

Query: 241 NKRCKDKKKSILMKQLQQQQHSDKTSLQGLTGTPLVAGSPIRHENAVQGSAVEVQTYQPP 300
           NKRCKDKKKSILMKQLQQQQHSDKTSLQGLTGTPLVAGSPIRHENAVQGSAVEVQTYQPP
Sbjct: 241 NKRCKDKKKSILMKQLQQQQHSDKTSLQGLTGTPLVAGSPIRHENAVQGSAVEVQTYQPP 300

Query: 301 WKALSEFALQSDLDQPAFQQLVSFSESGSLGNSSGSDVTSLSSQLPDTPNSMVPSPVET 359
           WKALSEFALQSDLDQPAFQQLVSFSESGSLGNSSGSDVTSLSSQLPDTPNSMVPSPVET
Sbjct: 301 WKALSEFALQSDLDQPAFQQLVSFSESGSLGNSSGSDVTSLSSQLPDTPNSMVPSPVET 359


>gi|115387114 islet-1 [Homo sapiens]
          Length = 349

 Score =  551 bits (1421), Expect = e-157
 Identities = 264/349 (75%), Positives = 301/349 (86%), Gaps = 2/349 (0%)

Query: 11  LGAMGDHSKKKPGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFV 70
           +G MGD  KKK   ++CVGCG+QIHDQ+ILRVSPDLEWHAACLKCAEC+QYLDE+CTCFV
Sbjct: 1   MGDMGDPPKKKRLISLCVGCGNQIHDQYILRVSPDLEWHAACLKCAECNQYLDESCTCFV 60

Query: 71  RDGKTYCKRDYVRLFGIKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEF 130
           RDGKTYCKRDY+RL+GIKCAKC +GFS +D VMRAR  VYHIECFRC  CSRQL+PGDEF
Sbjct: 61  RDGKTYCKRDYIRLYGIKCAKCSIGFSKNDFVMRARSKVYHIECFRCVACSRQLIPGDEF 120

Query: 131 SLREHELLCRADHGLLLERAAAGSPRSPGPLPGARGLHLP-DAGSGRQPALRPHVHKQTE 189
           +LRE  L CRADH ++ ERA+ G+     PL  AR L +  +  S RQPALRPHVHKQ E
Sbjct: 121 ALREDGLFCRADHDVV-ERASLGAGDPLSPLHPARPLQMAAEPISARQPALRPHVHKQPE 179

Query: 190 KTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKK 249
           KTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKK+
Sbjct: 180 KTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKR 239

Query: 250 SILMKQLQQQQHSDKTSLQGLTGTPLVAGSPIRHENAVQGSAVEVQTYQPPWKALSEFAL 309
           SI+MKQLQQQQ +DKT++QG+TGTP+VA SP RH+  +Q + VEVQ+YQPPWK LS+FAL
Sbjct: 240 SIMMKQLQQQQPNDKTNIQGMTGTPMVAASPERHDGGLQANPVEVQSYQPPWKVLSDFAL 299

Query: 310 QSDLDQPAFQQLVSFSESGSLGNSSGSDVTSLSSQLPDTPNSMVPSPVE 358
           QSD+DQPAFQQLV+FSE G   NS+GS+V S+SSQLPDTPNSMV SP+E
Sbjct: 300 QSDIDQPAFQQLVNFSEGGPGSNSTGSEVASMSSQLPDTPNSMVASPIE 348


>gi|33569216 LIM homeobox 9 isoform 1 [Homo sapiens]
          Length = 397

 Score =  181 bits (460), Expect = 7e-46
 Identities = 104/283 (36%), Positives = 155/283 (54%), Gaps = 37/283 (13%)

Query: 18  SKKKPGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRDGKTYC 77
           S +KP  A+C GCG +I D++ L ++ D +WH  CLKC EC   L+   TCF +DG  YC
Sbjct: 64  SPEKP--ALCAGCGGKISDRYYL-LAVDKQWHLRCLKCCECKLALESELTCFAKDGSIYC 120

Query: 78  KRDYVRLFGI-KCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLREHE 136
           K DY R F + +CA+C +G S+S++VMRARDSVYH+ CF CS C++ L  GD F +++  
Sbjct: 121 KEDYYRRFSVQRCARCHLGISASEMVMRARDSVYHLSCFTCSTCNKTLTTGDHFGMKDSL 180

Query: 137 LLCRADHGLLLE------------RAAAGSPRSP-----GPLPGAR---------GLHLP 170
           + CRA    LL+             A +G    P     G +   R         G+ + 
Sbjct: 181 VYCRAHFETLLQGEYPPQLSYTELAAKSGGLALPYFNGTGTVQKGRPRKRKSPALGVDIV 240

Query: 171 DAGSGRQPALRPHVHKQ------TEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQL 224
           +  SG       H+ +       ++KT R+RT     QL T+++ +A N  PDA   +QL
Sbjct: 241 NYNSGCNENEADHLDRDQQPYPPSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQL 300

Query: 225 VEMTGLSPRVIRVWFQNKRCKDKKKSILMKQLQQQQHSDKTSL 267
            + TGL+ RV++VWFQN R K  ++++L ++      +D TSL
Sbjct: 301 AQKTGLTKRVLQVWFQNARAK-FRRNLLRQENGGVDKADGTSL 342


>gi|62241033 LIM homeobox 9 isoform 2 [Homo sapiens]
          Length = 388

 Score =  181 bits (460), Expect = 7e-46
 Identities = 104/283 (36%), Positives = 155/283 (54%), Gaps = 37/283 (13%)

Query: 18  SKKKPGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRDGKTYC 77
           S +KP  A+C GCG +I D++ L ++ D +WH  CLKC EC   L+   TCF +DG  YC
Sbjct: 55  SPEKP--ALCAGCGGKISDRYYL-LAVDKQWHLRCLKCCECKLALESELTCFAKDGSIYC 111

Query: 78  KRDYVRLFGI-KCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLREHE 136
           K DY R F + +CA+C +G S+S++VMRARDSVYH+ CF CS C++ L  GD F +++  
Sbjct: 112 KEDYYRRFSVQRCARCHLGISASEMVMRARDSVYHLSCFTCSTCNKTLTTGDHFGMKDSL 171

Query: 137 LLCRADHGLLLE------------RAAAGSPRSP-----GPLPGAR---------GLHLP 170
           + CRA    LL+             A +G    P     G +   R         G+ + 
Sbjct: 172 VYCRAHFETLLQGEYPPQLSYTELAAKSGGLALPYFNGTGTVQKGRPRKRKSPALGVDIV 231

Query: 171 DAGSGRQPALRPHVHKQ------TEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQL 224
           +  SG       H+ +       ++KT R+RT     QL T+++ +A N  PDA   +QL
Sbjct: 232 NYNSGCNENEADHLDRDQQPYPPSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQL 291

Query: 225 VEMTGLSPRVIRVWFQNKRCKDKKKSILMKQLQQQQHSDKTSL 267
            + TGL+ RV++VWFQN R K  ++++L ++      +D TSL
Sbjct: 292 AQKTGLTKRVLQVWFQNARAK-FRRNLLRQENGGVDKADGTSL 333


>gi|30795196 LIM homeobox protein 2 [Homo sapiens]
          Length = 406

 Score =  177 bits (449), Expect = 1e-44
 Identities = 106/300 (35%), Positives = 153/300 (51%), Gaps = 54/300 (18%)

Query: 25  AMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRDGKTYCKRDYVRL 84
           A+C GCG +I D++ L ++ D +WH  CLKC EC   L+   TCF +DG  YCK DY R 
Sbjct: 51  ALCAGCGGKISDRYYL-LAVDKQWHMRCLKCCECKLNLESELTCFSKDGSIYCKEDYYRR 109

Query: 85  FGI-KCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLREHELLCRADH 143
           F + +CA+C +G S+S++VMRARD VYH+ CF C+ C++ L  GD F +++  + CR   
Sbjct: 110 FSVQRCARCHLGISASEMVMRARDLVYHLNCFTCTTCNKMLTTGDHFGMKDSLVYCRLHF 169

Query: 144 GLLLE---------------RAAAGSPRSPG-PLPGARGLHLP----------------- 170
             LL+                AAA + +S G    GA  L LP                 
Sbjct: 170 EALLQGEYPAHFNHADVAAAAAAAAAAKSAGLGAAGANPLGLPYYNGVGTVQKGRPRKRK 229

Query: 171 DAGSGRQPAL----------------RPHVHKQTEKTTRVRTVLNEKQLHTLRTCYAANP 214
             G G   A                 R   +  ++KT R+RT     QL T+++ +A N 
Sbjct: 230 SPGPGADLAAYNAALSCNENDAEHLDRDQPYPSSQKTKRMRTSFKHHQLRTMKSYFAINH 289

Query: 215 RPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKKSILMKQLQQQQHSDKTSLQGLTGTP 274
            PDA   +QL + TGL+ RV++VWFQN R K  ++++L ++      S   +LQ  TGTP
Sbjct: 290 NPDAKDLKQLAQKTGLTKRVLQVWFQNARAK-FRRNLLRQENTGVDKSTDAALQ--TGTP 346


>gi|4505007 LIM homeobox transcription factor 1, beta [Homo sapiens]
          Length = 372

 Score =  177 bits (448), Expect = 2e-44
 Identities = 116/337 (34%), Positives = 172/337 (51%), Gaps = 22/337 (6%)

Query: 22  PGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRDGKTYCKRDY 81
           P  A+C GC   I D+F++RV+ +  WH  CL+CA C Q L  T +C+ RD K YCK+DY
Sbjct: 28  PHPAVCEGCQRPISDRFLMRVN-ESSWHEECLQCAACQQAL--TTSCYFRDRKLYCKQDY 84

Query: 82  VRLFGIKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLREHELLCRA 141
            +LF  KC+ C    + ++ VMRA + VYH+ CF C VC RQL  GDEF L+E +LLC+ 
Sbjct: 85  QQLFAAKCSGCMEKIAPTEFVMRALECVYHLGCFCCCVCERQLRKGDEFVLKEGQLLCKG 144

Query: 142 DHGLLLERAAAGSPRSPGPLPG--ARGLHLPDAGSGRQPALRPHVHKQTEKTTRVRTVLN 199
           D+    +  ++ SP     +      G   P  G G Q        K   +  R RT+L 
Sbjct: 145 DYEKEKDLLSSVSPDESDSVKSEDEDGDMKPAKGQGSQSKGSGDDGKDPRRPKRPRTILT 204

Query: 200 EKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKKSILMKQLQQQ 259
            +Q    +  +  + +P   ++E L   TGLS RV++VWFQN+R K KK +   +Q Q+Q
Sbjct: 205 TQQRRAFKASFEVSSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKMKKLARRHQQQQEQ 264

Query: 260 QHSDKTSLQGLTG---------TPLVAGSP--IRHENAVQGSAVEVQTYQPPWKALSEFA 308
           Q+S +   + L+          TPL       +  E +  GS+   Q    P +     +
Sbjct: 265 QNSQRLGQEVLSSRMEGMMASYTPLAPPQQQIVAMEQSPYGSSDPFQQGLTPPQMPGNDS 324

Query: 309 LQSDLDQPAFQQLVSFSESGSLGNSSGSDVTSLSSQL 345
           +  D+D      L S S+   LG+   SDV SL +++
Sbjct: 325 IFHDIDSDT--SLTSLSDC-FLGS---SDVGSLQARV 355


>gi|28893581 LIM homeobox transcription factor 1, alpha isoform a
           [Homo sapiens]
          Length = 382

 Score =  175 bits (443), Expect = 6e-44
 Identities = 99/256 (38%), Positives = 142/256 (55%), Gaps = 12/256 (4%)

Query: 25  AMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRDGKTYCKRDYVRL 84
           ++C GC   I D+F+LR++ D  WH  C++CA C + L+ TC  F RD K YCK DY +L
Sbjct: 33  SVCEGCQRVILDRFLLRLN-DSFWHEQCVQCASCKEPLETTC--FYRDKKLYCKYDYEKL 89

Query: 85  FGIKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLREHELLCRADHG 144
           F +KC  C    + ++ VMRA+ SVYH+ CF C VC RQL  GDEF L+E +LLC+ D+ 
Sbjct: 90  FAVKCGGCFEAIAPNEFVMRAQKSVYHLSCFCCCVCERQLQKGDEFVLKEGQLLCKGDYE 149

Query: 145 LLLERAAAGSPRS--PGPLPGARGLHLPDAGSGRQPALRPHVHKQTEKTTRVRTVLNEKQ 202
              E  +  SP +   G       L     G+G+  A     HK+ +   R RT+L  +Q
Sbjct: 150 KERELLSLVSPAASDSGKSDDEESLCKSAHGAGKGTAEEGKDHKRPK---RPRTILTTQQ 206

Query: 203 LHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKKSILMKQLQQQQHS 262
               +  +  + +P   ++E L   TGLS RV++VWFQN+R K KK    + + QQQQ  
Sbjct: 207 RRAFKASFEVSSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKMKK----LARRQQQQQQ 262

Query: 263 DKTSLQGLTGTPLVAG 278
           D+ + Q L+      G
Sbjct: 263 DQQNTQRLSSAQTNGG 278


>gi|30023847 LIM homeobox protein 3 isoform a [Homo sapiens]
          Length = 397

 Score =  164 bits (415), Expect = 1e-40
 Identities = 115/342 (33%), Positives = 161/342 (47%), Gaps = 61/342 (17%)

Query: 26  MCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRDGKTYCKRDYVRLF 85
           +C GC   I D+FIL+   D  WH+ CLKC++C   L E C  F R    YCK D+ + F
Sbjct: 30  LCAGCDQHILDRFILKAL-DRHWHSKCLKCSDCHTPLAERC--FSRGESVYCKDDFFKRF 86

Query: 86  GIKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLRE-HELLCRADHG 144
           G KCA CQ+G   + +V RA+D VYH+ CF C VC RQL  GDEF L E   L+C+AD+ 
Sbjct: 87  GTKCAACQLGIPPTQVVRRAQDFVYHLHCFACVVCKRQLATGDEFYLMEDSRLVCKADYE 146

Query: 145 LLLERAAAGSPRSPGPLPGARGLHLPDAGSGRQPALRPHVHKQTEKTTRVRTVLNEKQLH 204
              +R A  + + P                                    RT +  KQL 
Sbjct: 147 TAKQREAEATAKRP------------------------------------RTTITAKQLE 170

Query: 205 TLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKK-KSILMKQLQQQQHSD 263
           TL++ Y  +P+P   ++EQL   TGL  RV++VWFQN+R K+K+ K    +Q   Q   +
Sbjct: 171 TLKSAYNTSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRQRWGQYFRN 230

Query: 264 KTSLQGLTGTPLVAGSPIRHENAVQGSAVEVQTYQPPWKALSEF----ALQSDLDQPAFQ 319
               +G        GS    ++  +G   + +   P   +L+E      L   L +P  Q
Sbjct: 231 MKRSRG--------GSKSDKDSVQEGQDSDAEVSFPDEPSLAEMGPANGLYGSLGEPT-Q 281

Query: 320 QLVSFSESGSLGNSS----GSDVTSLSSQL-PDTPNSMVPSP 356
            L     SG+LGN S    G        +L P +P  + PSP
Sbjct: 282 AL--GRPSGALGNFSLEHGGLAGPEQYRELRPGSPYGVPPSP 321


>gi|7657303 LIM homeobox protein 3 isoform b [Homo sapiens]
          Length = 402

 Score =  164 bits (415), Expect = 1e-40
 Identities = 115/342 (33%), Positives = 161/342 (47%), Gaps = 61/342 (17%)

Query: 26  MCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRDGKTYCKRDYVRLF 85
           +C GC   I D+FIL+   D  WH+ CLKC++C   L E C  F R    YCK D+ + F
Sbjct: 35  LCAGCDQHILDRFILKAL-DRHWHSKCLKCSDCHTPLAERC--FSRGESVYCKDDFFKRF 91

Query: 86  GIKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLRE-HELLCRADHG 144
           G KCA CQ+G   + +V RA+D VYH+ CF C VC RQL  GDEF L E   L+C+AD+ 
Sbjct: 92  GTKCAACQLGIPPTQVVRRAQDFVYHLHCFACVVCKRQLATGDEFYLMEDSRLVCKADYE 151

Query: 145 LLLERAAAGSPRSPGPLPGARGLHLPDAGSGRQPALRPHVHKQTEKTTRVRTVLNEKQLH 204
              +R A  + + P                                    RT +  KQL 
Sbjct: 152 TAKQREAEATAKRP------------------------------------RTTITAKQLE 175

Query: 205 TLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKK-KSILMKQLQQQQHSD 263
           TL++ Y  +P+P   ++EQL   TGL  RV++VWFQN+R K+K+ K    +Q   Q   +
Sbjct: 176 TLKSAYNTSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRQRWGQYFRN 235

Query: 264 KTSLQGLTGTPLVAGSPIRHENAVQGSAVEVQTYQPPWKALSEF----ALQSDLDQPAFQ 319
               +G        GS    ++  +G   + +   P   +L+E      L   L +P  Q
Sbjct: 236 MKRSRG--------GSKSDKDSVQEGQDSDAEVSFPDEPSLAEMGPANGLYGSLGEPT-Q 286

Query: 320 QLVSFSESGSLGNSS----GSDVTSLSSQL-PDTPNSMVPSP 356
            L     SG+LGN S    G        +L P +P  + PSP
Sbjct: 287 AL--GRPSGALGNFSLEHGGLAGPEQYRELRPGSPYGVPPSP 326


>gi|30410785 LIM homeobox protein 1 [Homo sapiens]
          Length = 406

 Score =  164 bits (414), Expect = 1e-40
 Identities = 96/247 (38%), Positives = 131/247 (53%), Gaps = 26/247 (10%)

Query: 27  CVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRDGKTYCKRDYVRLFG 86
           C GC   I D+F+L V  D  WH  C++C EC   L E C  F R+GK YCK D+ R FG
Sbjct: 4   CAGCKRPILDRFLLNVL-DRAWHVKCVQCCECKCNLTEKC--FSREGKLYCKNDFFRCFG 60

Query: 87  IKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDE-FSLREHELLCRADH-- 143
            KCA C  G S SDLV RAR  V+H+ CF C +C++QL  G+E + + E++ +C+ D+  
Sbjct: 61  TKCAGCAQGISPSDLVRRARSKVFHLNCFTCMMCNKQLSTGEELYIIDENKFVCKEDYLS 120

Query: 144 ------GLLLERAAAGSPRSPGPLPGARGLHLPDAGSGRQPALRPHVHKQTE-------- 189
                    L  A  GS   P   P ++     DA       +        E        
Sbjct: 121 NSSVAKENSLHSATTGS--DPSLSPDSQDPSQDDAKDSESANVSDKEAGSNENDDQNLGA 178

Query: 190 KTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKK 249
           K    RT +  KQL TL+  +AA P+P   ++EQL + TGL+ RVI+VWFQN+R K+++ 
Sbjct: 179 KRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERR- 237

Query: 250 SILMKQL 256
              MKQL
Sbjct: 238 ---MKQL 241


>gi|11641283 LIM homeobox protein 5 [Homo sapiens]
          Length = 402

 Score =  161 bits (408), Expect = 7e-40
 Identities = 95/252 (37%), Positives = 132/252 (52%), Gaps = 37/252 (14%)

Query: 27  CVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRDGKTYCKRDYVRLFG 86
           C GC   I D+F+L V  D  WH  C++C EC   L E C  F R+GK YCK D+ R FG
Sbjct: 5   CAGCERPILDRFLLNVL-DRAWHIKCVQCCECKTNLSEKC--FSREGKLYCKNDFFRRFG 61

Query: 87  IKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDE-FSLREHELLCRADHGL 145
            KCA C  G S SDLV +AR  V+H+ CF C VC++QL  G+E + + E++ +C+ D+  
Sbjct: 62  TKCAGCAQGISPSDLVRKARSKVFHLNCFTCMVCNKQLSTGEELYVIDENKFVCKDDY-- 119

Query: 146 LLERAAAGSPRSPGPLPGARGLHLPDAGSGRQPALRPHVHKQTEKTTR------------ 193
                 + S    G L               Q AL+    K+T+ +T             
Sbjct: 120 -----LSSSSLKEGSLNSVSSCTDRSLSPDLQDALQDD-PKETDNSTSSDKETANNENEE 173

Query: 194 ---------VRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRC 244
                     RT +  KQL TL+  +AA P+P   ++EQL + TGL+ RVI+VWFQN+R 
Sbjct: 174 QNSGTKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRS 233

Query: 245 KDKKKSILMKQL 256
           K+++    MKQL
Sbjct: 234 KERR----MKQL 241


>gi|15375314 LIM homeobox protein 4 [Homo sapiens]
          Length = 390

 Score =  160 bits (405), Expect = 2e-39
 Identities = 88/223 (39%), Positives = 117/223 (52%), Gaps = 39/223 (17%)

Query: 27  CVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRDGKTYCKRDYVRLFG 86
           C GC   I D+FIL+V  D  WH++CLKCA+C   L + C  F R G  YCK D+ + FG
Sbjct: 30  CAGCNQHILDKFILKVL-DRHWHSSCLKCADCQMQLADRC--FSRAGSVYCKEDFFKRFG 86

Query: 87  IKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLREH-ELLCRADHGL 145
            KC  CQ G   + +V +A+D VYH+ CF C +C+RQL  GDEF L E   L+C+ D+  
Sbjct: 87  TKCTACQQGIPPTQVVRKAQDFVYHLHCFACIICNRQLATGDEFYLMEDGRLVCKEDY-- 144

Query: 146 LLERAAAGSPRSPGPLPGARGLHLPDAGSGRQPALRPHVHKQTEKTTRVRTVLNEKQLHT 205
             E A        G                   A RP            RT +  KQL T
Sbjct: 145 --ETAKQNDDSEAG-------------------AKRP------------RTTITAKQLET 171

Query: 206 LRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKK 248
           L+  Y  +P+P   ++EQL   TGL  RV++VWFQN+R K+K+
Sbjct: 172 LKNAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKR 214


>gi|50083287 LIM homeobox 8 [Homo sapiens]
          Length = 356

 Score =  159 bits (401), Expect = 5e-39
 Identities = 85/236 (36%), Positives = 125/236 (52%), Gaps = 14/236 (5%)

Query: 13  AMGDHSKKKPGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRD 72
           +M   S   PG  +C  CG +I D+++L+V+ DL WH  CL C+ C   L    +C+++D
Sbjct: 61  SMASGSGCPPGKCVCNSCGLEIVDKYLLKVN-DLCWHVRCLSCSVCRTSLGRHTSCYIKD 119

Query: 73  GKTYCKRDYVRLFGIKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSL 132
              +CK DY R +G +C++C     S+D V RA+ +VYH+ CF C  C RQL  G+EF+L
Sbjct: 120 KDIFCKLDYFRRYGTRCSRCGRHIHSTDWVRRAKGNVYHLACFACFSCKRQLSTGEEFAL 179

Query: 133 REHELLCRADHGLLLERAAAGSPRSPGPLPGARGLHLPDAGSGRQPALRPHVHKQTEKTT 192
            E ++LCR  +  +L+            +    G+ +  A    Q    P   K      
Sbjct: 180 VEEKVLCRVHYDCMLDNLKR-------EVENGNGISVEGALLTEQDVNHPKPAK------ 226

Query: 193 RVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKK 248
           R RT     QL  ++  +A +  PDA   ++L E TGLS RVI+VWFQN R + KK
Sbjct: 227 RARTSFTADQLQVMQAQFAQDNNPDAQTLQKLAERTGLSRRVIQVWFQNCRARHKK 282


>gi|134284361 LIM homeobox protein 6 isoform 2 [Homo sapiens]
          Length = 377

 Score =  158 bits (399), Expect = 8e-39
 Identities = 83/226 (36%), Positives = 124/226 (54%), Gaps = 15/226 (6%)

Query: 23  GTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRDGKTYCKRDYV 82
           G  +C  CG +I D+++L+V+ +L WH  CL+C+ C   L +  +C++++ + +CK DY 
Sbjct: 95  GKNICSSCGLEILDRYLLKVN-NLIWHVRCLECSVCRTSLRQQNSCYIKNKEIFCKMDYF 153

Query: 83  RLFGIKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLREHELLCRAD 142
             FG KCA+C     +SD V RAR + YH+ CF C  C RQL  G+EF L E ++LCR  
Sbjct: 154 SRFGTKCARCGRQIYASDWVRRARGNAYHLACFACFSCKRQLSTGEEFGLVEEKVLCRIH 213

Query: 143 HGLLLERAAAGSPRSPGPLPGARGLHLPDAGSGRQPALRPHVHKQTEKTTRVRTVLNEKQ 202
           +  ++E     +           GL L  A    Q +       Q +   R RT    +Q
Sbjct: 214 YDTMIENLKRAA-------ENGNGLTLEGAVPSEQDS-------QPKPAKRARTSFTAEQ 259

Query: 203 LHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKK 248
           L  ++  +A +  PDA   ++L +MTGLS RVI+VWFQN R + KK
Sbjct: 260 LQVMQAQFAQDNNPDAQTLQKLADMTGLSRRVIQVWFQNCRARHKK 305


>gi|134284359 LIM homeobox protein 6 isoform 1 [Homo sapiens]
          Length = 392

 Score =  158 bits (399), Expect = 8e-39
 Identities = 83/226 (36%), Positives = 124/226 (54%), Gaps = 15/226 (6%)

Query: 23  GTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRDGKTYCKRDYV 82
           G  +C  CG +I D+++L+V+ +L WH  CL+C+ C   L +  +C++++ + +CK DY 
Sbjct: 95  GKNICSSCGLEILDRYLLKVN-NLIWHVRCLECSVCRTSLRQQNSCYIKNKEIFCKMDYF 153

Query: 83  RLFGIKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLREHELLCRAD 142
             FG KCA+C     +SD V RAR + YH+ CF C  C RQL  G+EF L E ++LCR  
Sbjct: 154 SRFGTKCARCGRQIYASDWVRRARGNAYHLACFACFSCKRQLSTGEEFGLVEEKVLCRIH 213

Query: 143 HGLLLERAAAGSPRSPGPLPGARGLHLPDAGSGRQPALRPHVHKQTEKTTRVRTVLNEKQ 202
           +  ++E     +           GL L  A    Q +       Q +   R RT    +Q
Sbjct: 214 YDTMIENLKRAA-------ENGNGLTLEGAVPSEQDS-------QPKPAKRARTSFTAEQ 259

Query: 203 LHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKK 248
           L  ++  +A +  PDA   ++L +MTGLS RVI+VWFQN R + KK
Sbjct: 260 LQVMQAQFAQDNNPDAQTLQKLADMTGLSRRVIQVWFQNCRARHKK 305


>gi|5803072 LIM domain only 4 [Homo sapiens]
          Length = 165

 Score =  112 bits (281), Expect = 4e-25
 Identities = 61/157 (38%), Positives = 83/157 (52%), Gaps = 10/157 (6%)

Query: 15  GDHSKKKPGTA------MCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCT- 67
           G  S+  P TA       C GCG +I D+F+L  + D  WH+ CLKC+ C   L +  T 
Sbjct: 5   GSSSQPPPVTAGSLSWKRCAGCGGKIADRFLL-YAMDSYWHSRCLKCSCCQAQLGDIGTS 63

Query: 68  CFVRDGKTYCKRDYVRLFGIK--CAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLL 125
           C+ + G   C+ DY+RLFG    C+ C     +S+LVMRA+ +VYH++CF CS C  +L+
Sbjct: 64  CYTKSGMILCRNDYIRLFGNSGACSACGQSIPASELVMRAQGNVYHLKCFTCSTCRNRLV 123

Query: 126 PGDEFSLREHELLCRADHGLLLERAAAGSPRSPGPLP 162
           PGD F      L C  D    L      S +S   LP
Sbjct: 124 PGDRFHYINGSLFCEHDRPTALINGHLNSLQSNPLLP 160


>gi|21361802 LIM domain only 3 [Homo sapiens]
          Length = 145

 Score =  107 bits (267), Expect = 2e-23
 Identities = 51/127 (40%), Positives = 79/127 (62%), Gaps = 6/127 (4%)

Query: 27  CVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDET-CTCFVRDGKTYCKRDYVRLF 85
           C GC  +I D+++L+   D  WH  CLKCA C   L E   T + +     C+RDY+RLF
Sbjct: 13  CAGCNRKIKDRYLLKAL-DKYWHEDCLKCACCDCRLGEVGSTLYTKANLILCRRDYLRLF 71

Query: 86  GI--KCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLREHELLCRADH 143
           G+   CA C     + ++VMRA+D+VYH++CF C +C+++   GD+F L+ + +LC+ D+
Sbjct: 72  GVTGNCAACSKLIPAFEMVMRAKDNVYHLDCFACQLCNQRFCVGDKFFLKNNMILCQTDY 131

Query: 144 --GLLLE 148
             GL+ E
Sbjct: 132 EEGLMKE 138


>gi|47778935 LIM domain only 3 [Homo sapiens]
          Length = 145

 Score =  107 bits (267), Expect = 2e-23
 Identities = 51/127 (40%), Positives = 79/127 (62%), Gaps = 6/127 (4%)

Query: 27  CVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDET-CTCFVRDGKTYCKRDYVRLF 85
           C GC  +I D+++L+   D  WH  CLKCA C   L E   T + +     C+RDY+RLF
Sbjct: 13  CAGCNRKIKDRYLLKAL-DKYWHEDCLKCACCDCRLGEVGSTLYTKANLILCRRDYLRLF 71

Query: 86  GI--KCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLREHELLCRADH 143
           G+   CA C     + ++VMRA+D+VYH++CF C +C+++   GD+F L+ + +LC+ D+
Sbjct: 72  GVTGNCAACSKLIPAFEMVMRAKDNVYHLDCFACQLCNQRFCVGDKFFLKNNMILCQTDY 131

Query: 144 --GLLLE 148
             GL+ E
Sbjct: 132 EEGLMKE 138


>gi|4505005 LIM domain only 1 [Homo sapiens]
          Length = 156

 Score =  105 bits (263), Expect = 5e-23
 Identities = 49/120 (40%), Positives = 74/120 (61%), Gaps = 4/120 (3%)

Query: 27  CVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDET-CTCFVRDGKTYCKRDYVRLF 85
           C GC  +I D+++L+   D  WH  CLKCA C   L E   T + +     C+RDY+RLF
Sbjct: 24  CAGCNRKIKDRYLLKAL-DKYWHEDCLKCACCDCRLGEVGSTLYTKANLILCRRDYLRLF 82

Query: 86  GI--KCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLREHELLCRADH 143
           G    CA C     + ++VMRARD+VYH++CF C +C+++   GD+F L+ + +LC+ D+
Sbjct: 83  GTTGNCAACSKLIPAFEMVMRARDNVYHLDCFACQLCNQRFCVGDKFFLKNNMILCQMDY 142


>gi|214832219 LIM domain only 2 isoform 2 [Homo sapiens]
          Length = 158

 Score = 92.4 bits (228), Expect = 5e-19
 Identities = 44/124 (35%), Positives = 64/124 (51%), Gaps = 4/124 (3%)

Query: 22  PGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCT-CFVRDGKTYCKRD 80
           P    C GC   I D++ L+   D  WH  CL C  C   L E     + + G+  C+RD
Sbjct: 25  PSLLTCGGCQQNIGDRYFLKAI-DQYWHEDCLSCDLCGCRLGEVGRRLYYKLGRKLCRRD 83

Query: 81  YVRLFGIK--CAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLREHELL 138
           Y+RLFG    CA C     + ++ MR +D VYH+ECF+C+ C +    GD + L   +++
Sbjct: 84  YLRLFGQDGLCASCDKRIRAYEMTMRVKDKVYHLECFKCAACQKHFCVGDRYLLINSDIV 143

Query: 139 CRAD 142
           C  D
Sbjct: 144 CEQD 147


>gi|214832121 LIM domain only 2 isoform 2 [Homo sapiens]
          Length = 158

 Score = 92.4 bits (228), Expect = 5e-19
 Identities = 44/124 (35%), Positives = 64/124 (51%), Gaps = 4/124 (3%)

Query: 22  PGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCT-CFVRDGKTYCKRD 80
           P    C GC   I D++ L+   D  WH  CL C  C   L E     + + G+  C+RD
Sbjct: 25  PSLLTCGGCQQNIGDRYFLKAI-DQYWHEDCLSCDLCGCRLGEVGRRLYYKLGRKLCRRD 83

Query: 81  YVRLFGIK--CAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLREHELL 138
           Y+RLFG    CA C     + ++ MR +D VYH+ECF+C+ C +    GD + L   +++
Sbjct: 84  YLRLFGQDGLCASCDKRIRAYEMTMRVKDKVYHLECFKCAACQKHFCVGDRYLLINSDIV 143

Query: 139 CRAD 142
           C  D
Sbjct: 144 CEQD 147


>gi|214832074 LIM domain only 2 isoform 1 [Homo sapiens]
          Length = 227

 Score = 92.4 bits (228), Expect = 5e-19
 Identities = 44/124 (35%), Positives = 64/124 (51%), Gaps = 4/124 (3%)

Query: 22  PGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCT-CFVRDGKTYCKRD 80
           P    C GC   I D++ L+   D  WH  CL C  C   L E     + + G+  C+RD
Sbjct: 94  PSLLTCGGCQQNIGDRYFLKAI-DQYWHEDCLSCDLCGCRLGEVGRRLYYKLGRKLCRRD 152

Query: 81  YVRLFGIK--CAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLREHELL 138
           Y+RLFG    CA C     + ++ MR +D VYH+ECF+C+ C +    GD + L   +++
Sbjct: 153 YLRLFGQDGLCASCDKRIRAYEMTMRVKDKVYHLECFKCAACQKHFCVGDRYLLINSDIV 212

Query: 139 CRAD 142
           C  D
Sbjct: 213 CEQD 216


>gi|4505001 LIM domain kinase 1 [Homo sapiens]
          Length = 647

 Score = 81.3 bits (199), Expect = 1e-15
 Identities = 52/159 (32%), Positives = 78/159 (49%), Gaps = 15/159 (9%)

Query: 14  MGDHSKKKPGTAMCVGCGSQIHD-QFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRD 72
           MG+   + P   +C  CG +I+D Q++  ++ D  WHA C +C +CS  L      + +D
Sbjct: 15  MGEEGSELP---VCASCGQRIYDGQYLQALNAD--WHADCFRCCDCSASLSHQY--YEKD 67

Query: 73  GKTYCKRDYVRLFGIKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSL 132
           G+ +CK+DY   +G  C  C    +   LVM A +  YH ECF C  C   +  GD ++L
Sbjct: 68  GQLFCKKDYWARYGESCHGCSEQITKG-LVMVAGELKYHPECFICLTCGTFIGDGDTYTL 126

Query: 133 REH-ELLCRADHGLLLERAAAGSPRSPGPLPGARGLHLP 170
            EH +L C   +          +P     LP + G HLP
Sbjct: 127 VEHSKLYCGHCY-----YQTVVTPVIEQILPDSPGSHLP 160


>gi|51173715 actin-binding LIM protein 1 isoform c [Homo sapiens]
          Length = 746

 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 42/120 (35%), Positives = 60/120 (50%), Gaps = 5/120 (4%)

Query: 14  MGDHSKKKPGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRDG 73
           M    K+   ++ C GCG  I +   L ++ D +WH  C KC  C + L  T     +DG
Sbjct: 153 MSSSPKETTFSSNCAGCGRDIKNGQAL-LALDKQWHLGCFKCKSCGKVL--TGEYISKDG 209

Query: 74  KTYCKRDYVRLFGIKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLR 133
             YC++DY  LFG+KC  C    +    V+ A D  YH  C RCS C++    G+E  L+
Sbjct: 210 APYCEKDYQGLFGVKCEACHQFITGK--VLEAGDKHYHPSCARCSRCNQMFTEGEEMYLQ 267



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 38/124 (30%), Positives = 56/124 (45%), Gaps = 6/124 (4%)

Query: 17  HSKKKPGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRDGKTY 76
           H  +KP    C  CG     + +LRV     +H  C  C  C   L +    F+++G+  
Sbjct: 30  HPSEKP-VIHCHKCGEPCKGE-VLRVQTK-HFHIKCFTCKVCGCDLAQG-GFFIKNGEYL 85

Query: 77  CKRDYVRLFGIKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLREHE 136
           C  DY R++G +C  C  G      V+ A    YH  CF C++C R   PGD  +    +
Sbjct: 86  CTLDYQRMYGTRCHGC--GEFVEGEVVTALGKTYHPNCFACTICKRPFPPGDRVTFNGRD 143

Query: 137 LLCR 140
            LC+
Sbjct: 144 CLCQ 147


>gi|51173713 actin-binding LIM protein 1 isoform b [Homo sapiens]
          Length = 718

 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 42/120 (35%), Positives = 60/120 (50%), Gaps = 5/120 (4%)

Query: 14  MGDHSKKKPGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRDG 73
           M    K+   ++ C GCG  I +   L ++ D +WH  C KC  C + L  T     +DG
Sbjct: 153 MSSSPKETTFSSNCAGCGRDIKNGQAL-LALDKQWHLGCFKCKSCGKVL--TGEYISKDG 209

Query: 74  KTYCKRDYVRLFGIKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLR 133
             YC++DY  LFG+KC  C    +    V+ A D  YH  C RCS C++    G+E  L+
Sbjct: 210 APYCEKDYQGLFGVKCEACHQFITGK--VLEAGDKHYHPSCARCSRCNQMFTEGEEMYLQ 267



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 38/124 (30%), Positives = 56/124 (45%), Gaps = 6/124 (4%)

Query: 17  HSKKKPGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRDGKTY 76
           H  +KP    C  CG     + +LRV     +H  C  C  C   L +    F+++G+  
Sbjct: 30  HPSEKP-VIHCHKCGEPCKGE-VLRVQTK-HFHIKCFTCKVCGCDLAQG-GFFIKNGEYL 85

Query: 77  CKRDYVRLFGIKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLREHE 136
           C  DY R++G +C  C  G      V+ A    YH  CF C++C R   PGD  +    +
Sbjct: 86  CTLDYQRMYGTRCHGC--GEFVEGEVVTALGKTYHPNCFACTICKRPFPPGDRVTFNGRD 143

Query: 137 LLCR 140
            LC+
Sbjct: 144 CLCQ 147


>gi|51173711 actin-binding LIM protein 1 isoform a [Homo sapiens]
          Length = 778

 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 42/120 (35%), Positives = 60/120 (50%), Gaps = 5/120 (4%)

Query: 14  MGDHSKKKPGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRDG 73
           M    K+   ++ C GCG  I +   L ++ D +WH  C KC  C + L  T     +DG
Sbjct: 213 MSSSPKETTFSSNCAGCGRDIKNGQAL-LALDKQWHLGCFKCKSCGKVL--TGEYISKDG 269

Query: 74  KTYCKRDYVRLFGIKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLR 133
             YC++DY  LFG+KC  C    +    V+ A D  YH  C RCS C++    G+E  L+
Sbjct: 270 APYCEKDYQGLFGVKCEACHQFITGK--VLEAGDKHYHPSCARCSRCNQMFTEGEEMYLQ 327



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 41/134 (30%), Positives = 60/134 (44%), Gaps = 8/134 (5%)

Query: 9   PFLGAMGD--HSKKKPGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETC 66
           PF+    D  H  +KP    C  CG     + +LRV     +H  C  C  C   L +  
Sbjct: 80  PFVAHPQDPHHPSEKP-VIHCHKCGEPCKGE-VLRVQTK-HFHIKCFTCKVCGCDLAQG- 135

Query: 67  TCFVRDGKTYCKRDYVRLFGIKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLP 126
             F+++G+  C  DY R++G +C  C  G      V+ A    YH  CF C++C R   P
Sbjct: 136 GFFIKNGEYLCTLDYQRMYGTRCHGC--GEFVEGEVVTALGKTYHPNCFACTICKRPFPP 193

Query: 127 GDEFSLREHELLCR 140
           GD  +    + LC+
Sbjct: 194 GDRVTFNGRDCLCQ 207


>gi|7662330 actin binding LIM protein family, member 3 [Homo
           sapiens]
          Length = 683

 Score = 75.1 bits (183), Expect = 9e-14
 Identities = 52/150 (34%), Positives = 68/150 (45%), Gaps = 14/150 (9%)

Query: 23  GTAMCVGCGSQI-HDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRDGKTYCKRDY 81
           G + C GC  +I H Q +L +  D +WH +C KC  CS  L  T     +DG  YC+ DY
Sbjct: 147 GPSHCAGCKEEIKHGQSLLAL--DKQWHVSCFKCQTCSVIL--TGEYISKDGVPYCESDY 202

Query: 82  VRLFGIKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLREHEL---L 138
              FGIKC  C    S    V+ A    YH  C RC  C +    G+E  L   E+   +
Sbjct: 203 HAQFGIKCETCDRYISGR--VLEAGGKHYHPTCARCVRCHQMFTEGEEMYLTGSEVWHPI 260

Query: 139 C----RADHGLLLERAAAGSPRSPGPLPGA 164
           C    RA+  L   R +  S   PG   G+
Sbjct: 261 CKQAARAEKKLKHRRTSETSISPPGSSIGS 290



 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 31/114 (27%), Positives = 55/114 (48%), Gaps = 5/114 (4%)

Query: 27  CVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRDGKTYCKRDYVRLFG 86
           C  CG     + ++RV  +  +H  C  C  C   L ++   F ++ +  C +DY +L+G
Sbjct: 23  CYRCGDTCKGE-VVRVHNN-HFHIRCFTCQVCGCGLAQS-GFFFKNQEYICTQDYQQLYG 79

Query: 87  IKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLREHELLCR 140
            +C  C+   +    V+ A    YH +CF CS+C +    GD+ +    E +C+
Sbjct: 80  TRCDSCRDFITGE--VISALGRTYHPKCFVCSLCRKPFPIGDKVTFSGKECVCQ 131


>gi|5031869 LIM domain kinase 2 isoform 2a [Homo sapiens]
          Length = 638

 Score = 72.4 bits (176), Expect = 6e-13
 Identities = 39/112 (34%), Positives = 55/112 (49%), Gaps = 4/112 (3%)

Query: 27  CVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRDGKTYCKRDYVRLFG 86
           C GCG  I    I   + +  WH +C +C+EC   L  T   + +DGK YC +DY   FG
Sbjct: 12  CPGCGDHIAPSQIWYRTVNETWHGSCFRCSECQDSL--TNWYYEKDGKLYCPKDYWGKFG 69

Query: 87  IKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLREHELL 138
             C  C +  +   +V  A +  YH ECF C  C   +  GD ++L +H  L
Sbjct: 70  EFCHGCSLLMTGPFMV--AGEFKYHPECFACMSCKVIIEDGDAYALVQHATL 119



 Score = 29.6 bits (65), Expect = 4.4
 Identities = 15/56 (26%), Positives = 26/56 (46%), Gaps = 2/56 (3%)

Query: 88  KCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLREHELLCRADH 143
           +C  C    + S +  R  +  +H  CFRCS C   L   + +  ++ +L C  D+
Sbjct: 11  RCPGCGDHIAPSQIWYRTVNETWHGSCFRCSECQDSLT--NWYYEKDGKLYCPKDY 64


>gi|194272207 actin binding LIM protein family, member 2 isoform 7
           [Homo sapiens]
          Length = 470

 Score = 71.2 bits (173), Expect = 1e-12
 Identities = 38/121 (31%), Positives = 57/121 (47%), Gaps = 5/121 (4%)

Query: 13  AMGDHSKKKPGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRD 72
           ++G  +    G   C GCG++I +   L V+ D  WH  C KC  C + L+       +D
Sbjct: 139 SVGSSAHLSQGLRSCGGCGTEIKNGQAL-VALDKHWHLGCFKCKSCGKLLN--AEYISKD 195

Query: 73  GKTYCKRDYVRLFGIKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSL 132
           G  YC+ DY   FGI+C  C+   +    V+ A +  YH  C  C  C +    G+E  L
Sbjct: 196 GLPYCEADYHAKFGIRCDSCEKYITGR--VLEAGEKHYHPSCALCVRCGQMFAEGEEMYL 253

Query: 133 R 133
           +
Sbjct: 254 Q 254



 Score = 69.3 bits (168), Expect = 5e-12
 Identities = 43/123 (34%), Positives = 58/123 (47%), Gaps = 6/123 (4%)

Query: 19  KKKPGTA-MCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRDGKTYC 77
           +K P TA +C  CG+    + +LRV  D  +H  C  C  C   L E    FVR G+  C
Sbjct: 15  EKSPSTAILCNTCGNVCKGE-VLRVQ-DKYFHIKCFVCKACGCDLAEG-GFFVRQGEYIC 71

Query: 78  KRDYVRLFGIKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLREHEL 137
             DY RL+G +C  C         V+ A    YH +CF C+VC     PGD  +    E 
Sbjct: 72  TLDYQRLYGTRCFSCDQFIEGE--VVSALGKTYHPDCFVCAVCRLPFPPGDRVTFNGKEC 129

Query: 138 LCR 140
           +C+
Sbjct: 130 MCQ 132



 Score = 28.9 bits (63), Expect = 7.5
 Identities = 14/46 (30%), Positives = 19/46 (41%)

Query: 22  PGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCT 67
           P  A+CV CG    +   + +     WH AC + A       ET T
Sbjct: 233 PSCALCVRCGQMFAEGEEMYLQGSSIWHPACRQAARTEDRNKETRT 278


>gi|153792514 actin binding LIM protein family, member 2 isoform 6
           [Homo sapiens]
          Length = 521

 Score = 71.2 bits (173), Expect = 1e-12
 Identities = 38/121 (31%), Positives = 57/121 (47%), Gaps = 5/121 (4%)

Query: 13  AMGDHSKKKPGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRD 72
           ++G  +    G   C GCG++I +   L V+ D  WH  C KC  C + L+       +D
Sbjct: 139 SVGSSAHLSQGLRSCGGCGTEIKNGQAL-VALDKHWHLGCFKCKSCGKLLN--AEYISKD 195

Query: 73  GKTYCKRDYVRLFGIKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSL 132
           G  YC+ DY   FGI+C  C+   +    V+ A +  YH  C  C  C +    G+E  L
Sbjct: 196 GLPYCEADYHAKFGIRCDSCEKYITGR--VLEAGEKHYHPSCALCVRCGQMFAEGEEMYL 253

Query: 133 R 133
           +
Sbjct: 254 Q 254



 Score = 69.3 bits (168), Expect = 5e-12
 Identities = 43/123 (34%), Positives = 58/123 (47%), Gaps = 6/123 (4%)

Query: 19  KKKPGTA-MCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRDGKTYC 77
           +K P TA +C  CG+    + +LRV  D  +H  C  C  C   L E    FVR G+  C
Sbjct: 15  EKSPSTAILCNTCGNVCKGE-VLRVQ-DKYFHIKCFVCKACGCDLAEG-GFFVRQGEYIC 71

Query: 78  KRDYVRLFGIKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLREHEL 137
             DY RL+G +C  C         V+ A    YH +CF C+VC     PGD  +    E 
Sbjct: 72  TLDYQRLYGTRCFSCDQFIEGE--VVSALGKTYHPDCFVCAVCRLPFPPGDRVTFNGKEC 129

Query: 138 LCR 140
           +C+
Sbjct: 130 MCQ 132



 Score = 28.9 bits (63), Expect = 7.5
 Identities = 14/46 (30%), Positives = 19/46 (41%)

Query: 22  PGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCT 67
           P  A+CV CG    +   + +     WH AC + A       ET T
Sbjct: 233 PSCALCVRCGQMFAEGEEMYLQGSSIWHPACRQAARTEDRNKETRT 278


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.133    0.412 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,776,834
Number of Sequences: 37866
Number of extensions: 810719
Number of successful extensions: 4151
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 334
Number of HSP's successfully gapped in prelim test: 131
Number of HSP's that attempted gapping in prelim test: 3243
Number of HSP's gapped (non-prelim): 729
length of query: 359
length of database: 18,247,518
effective HSP length: 103
effective length of query: 256
effective length of database: 14,347,320
effective search space: 3672913920
effective search space used: 3672913920
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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