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Search of human proteins with 219521831
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|219521831 adhesion molecule with Ig-like domain 2 [Homo
sapiens]
(522 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|219521831 adhesion molecule with Ig-like domain 2 [Homo sapiens] 1053 0.0
gi|32469517 adhesion molecule with Ig-like domain 2 [Homo sapiens] 1053 0.0
gi|153791466 AMIGO protein [Homo sapiens] 348 7e-96
gi|38454322 adhesion molecule with Ig-like domain 3 [Homo sapiens] 246 5e-65
gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens] 112 6e-25
gi|139948432 adlican [Homo sapiens] 107 3e-23
gi|126517478 peroxidasin homolog-like [Homo sapiens] 105 8e-23
gi|109150416 peroxidasin [Homo sapiens] 97 3e-20
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 96 8e-20
gi|31542244 leucine rich repeat and fibronectin type III domain ... 95 2e-19
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 94 3e-19
gi|51317373 netrin-G1 ligand [Homo sapiens] 92 9e-19
gi|188528675 slit homolog 1 [Homo sapiens] 91 3e-18
gi|122937309 leucine rich repeat containing 4B [Homo sapiens] 89 7e-18
gi|4759146 slit homolog 2 [Homo sapiens] 87 5e-17
gi|30425553 reticulon 4 receptor-like 1 [Homo sapiens] 86 1e-16
gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo sa... 84 2e-16
gi|40217823 SLIT and NTRK-like family, member 5 [Homo sapiens] 84 4e-16
gi|11321571 slit homolog 3 [Homo sapiens] 83 5e-16
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 83 7e-16
gi|4826772 insulin-like growth factor binding protein, acid labi... 82 9e-16
gi|52353306 leucine rich repeat containing 55 [Homo sapiens] 82 9e-16
gi|229089140 leucine rich repeat containing 24 [Homo sapiens] 82 1e-15
gi|225579152 insulin-like growth factor binding protein, acid la... 82 2e-15
gi|41582239 immunoglobulin superfamily containing leucine-rich r... 79 8e-15
gi|5031809 immunoglobulin superfamily containing leucine-rich re... 79 8e-15
gi|149773484 leucine rich repeat and fibronectin type III domain... 78 2e-14
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo... 78 2e-14
gi|40217825 slit and trk like 6 [Homo sapiens] 77 3e-14
gi|40217820 slit and trk like 3 protein [Homo sapiens] 77 3e-14
>gi|219521831 adhesion molecule with Ig-like domain 2 [Homo sapiens]
Length = 522
Score = 1053 bits (2723), Expect = 0.0
Identities = 522/522 (100%), Positives = 522/522 (100%)
Query: 1 MSLRVHTLPTLLGAVVRPGCRELLCLLMITVTVGPGASGVCPTACICATDIVSCTNKNLS 60
MSLRVHTLPTLLGAVVRPGCRELLCLLMITVTVGPGASGVCPTACICATDIVSCTNKNLS
Sbjct: 1 MSLRVHTLPTLLGAVVRPGCRELLCLLMITVTVGPGASGVCPTACICATDIVSCTNKNLS 60
Query: 61 KVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLK 120
KVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLK
Sbjct: 61 KVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLK 120
Query: 121 CLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQF 180
CLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQF
Sbjct: 121 CLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQF 180
Query: 181 PMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLL 240
PMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLL
Sbjct: 181 PMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLL 240
Query: 241 VFWYRRHFSSVMDFKNDYTCRLWSDSRHSRQVLLLQDSFMNCSDSIINGSFRALGFIHEA 300
VFWYRRHFSSVMDFKNDYTCRLWSDSRHSRQVLLLQDSFMNCSDSIINGSFRALGFIHEA
Sbjct: 241 VFWYRRHFSSVMDFKNDYTCRLWSDSRHSRQVLLLQDSFMNCSDSIINGSFRALGFIHEA 300
Query: 301 QVGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGV 360
QVGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGV
Sbjct: 301 QVGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGV 360
Query: 361 YSCIAMNKQRLLNETVDVTINVSNFTVSRSHAHEAFNTAFTTLAACVASIVLVLLYLYLT 420
YSCIAMNKQRLLNETVDVTINVSNFTVSRSHAHEAFNTAFTTLAACVASIVLVLLYLYLT
Sbjct: 361 YSCIAMNKQRLLNETVDVTINVSNFTVSRSHAHEAFNTAFTTLAACVASIVLVLLYLYLT 420
Query: 421 PCPCKCKTKRQKNMLHQSNAHSSILSPGPASDASADERKAGAGKRVVFLEPLKDTAAGQN 480
PCPCKCKTKRQKNMLHQSNAHSSILSPGPASDASADERKAGAGKRVVFLEPLKDTAAGQN
Sbjct: 421 PCPCKCKTKRQKNMLHQSNAHSSILSPGPASDASADERKAGAGKRVVFLEPLKDTAAGQN 480
Query: 481 GKVRLFPSEAVIAEGILKSTRGKSDSDSVNSVFSDTPFVAST 522
GKVRLFPSEAVIAEGILKSTRGKSDSDSVNSVFSDTPFVAST
Sbjct: 481 GKVRLFPSEAVIAEGILKSTRGKSDSDSVNSVFSDTPFVAST 522
>gi|32469517 adhesion molecule with Ig-like domain 2 [Homo sapiens]
Length = 522
Score = 1053 bits (2723), Expect = 0.0
Identities = 522/522 (100%), Positives = 522/522 (100%)
Query: 1 MSLRVHTLPTLLGAVVRPGCRELLCLLMITVTVGPGASGVCPTACICATDIVSCTNKNLS 60
MSLRVHTLPTLLGAVVRPGCRELLCLLMITVTVGPGASGVCPTACICATDIVSCTNKNLS
Sbjct: 1 MSLRVHTLPTLLGAVVRPGCRELLCLLMITVTVGPGASGVCPTACICATDIVSCTNKNLS 60
Query: 61 KVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLK 120
KVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLK
Sbjct: 61 KVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLK 120
Query: 121 CLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQF 180
CLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQF
Sbjct: 121 CLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQF 180
Query: 181 PMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLL 240
PMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLL
Sbjct: 181 PMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLL 240
Query: 241 VFWYRRHFSSVMDFKNDYTCRLWSDSRHSRQVLLLQDSFMNCSDSIINGSFRALGFIHEA 300
VFWYRRHFSSVMDFKNDYTCRLWSDSRHSRQVLLLQDSFMNCSDSIINGSFRALGFIHEA
Sbjct: 241 VFWYRRHFSSVMDFKNDYTCRLWSDSRHSRQVLLLQDSFMNCSDSIINGSFRALGFIHEA 300
Query: 301 QVGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGV 360
QVGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGV
Sbjct: 301 QVGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGV 360
Query: 361 YSCIAMNKQRLLNETVDVTINVSNFTVSRSHAHEAFNTAFTTLAACVASIVLVLLYLYLT 420
YSCIAMNKQRLLNETVDVTINVSNFTVSRSHAHEAFNTAFTTLAACVASIVLVLLYLYLT
Sbjct: 361 YSCIAMNKQRLLNETVDVTINVSNFTVSRSHAHEAFNTAFTTLAACVASIVLVLLYLYLT 420
Query: 421 PCPCKCKTKRQKNMLHQSNAHSSILSPGPASDASADERKAGAGKRVVFLEPLKDTAAGQN 480
PCPCKCKTKRQKNMLHQSNAHSSILSPGPASDASADERKAGAGKRVVFLEPLKDTAAGQN
Sbjct: 421 PCPCKCKTKRQKNMLHQSNAHSSILSPGPASDASADERKAGAGKRVVFLEPLKDTAAGQN 480
Query: 481 GKVRLFPSEAVIAEGILKSTRGKSDSDSVNSVFSDTPFVAST 522
GKVRLFPSEAVIAEGILKSTRGKSDSDSVNSVFSDTPFVAST
Sbjct: 481 GKVRLFPSEAVIAEGILKSTRGKSDSDSVNSVFSDTPFVAST 522
>gi|153791466 AMIGO protein [Homo sapiens]
Length = 493
Score = 348 bits (893), Expect = 7e-96
Identities = 204/498 (40%), Positives = 291/498 (58%), Gaps = 24/498 (4%)
Query: 24 LCLLMITVTVGPGASGVCPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLL 83
L LL+ V A CP AC+CA++I+SC+ + L VP +L LDLS+N + L
Sbjct: 17 LSLLLFEVARAGRAVVSCPAACLCASNILSCSKQQLPNVPHSLPSYTALLDLSHNNLSRL 76
Query: 84 DSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVL 143
+EW P +L++L+L HN++ IS+ +FS PNL+ LDLSSN+L+T+ +F +L+VL
Sbjct: 77 RAEWTPTRLTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQVL 136
Query: 144 EVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNR 203
EVLLLYNNHI +D AF ++QLQKLYLS N +++FP++L KL +L LD+S N+
Sbjct: 137 EVLLLYNNHIMAVDRCAFDDMAQLQKLYLSQNQISRFPLELVKEGAKLPKLTLLDLSSNK 196
Query: 204 IPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLLVFWYRRHFSSVMDFKNDYTCRLW 263
+ ++P+ + +P G+YLH NP CDC LY L W R SSVMDF+ D C
Sbjct: 197 LKNLPLPDLQKLPAWIKNGLYLHNNPLNCDCELYQLFSHWQYRQLSSVMDFQEDLYC--- 253
Query: 264 SDSRHSRQVLLLQDSFMNCSDSIINGSFRALGFIHEAQVGERLMVHCDSKTGNANTDFIW 323
+S+ V L SF+NC G ++ + EA +G+ L++ CD+K +W
Sbjct: 254 MNSKKLHNVFNL--SFLNC------GEYKERAW--EAHLGDTLIIKCDTKQQGMTK--VW 301
Query: 324 VGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGVYSCIAMNKQRLLNETVDVTINVS 383
V P N + + V +GSL+ + + ED GVY+C AM + NET+ V + V
Sbjct: 302 VTPSNERVLDEVTNGTVSVSKDGSLLFQQVQVEDGGVYTCYAMGE--TFNETLSVELKVH 359
Query: 384 NFTVSRSHAHEAFNTAFTTLAACVASIVLVLLYLYLTPCPCKCKTKRQKNMLHQSNAHSS 443
NFT+ H H+ NTA+TTL C+ S+VLVL+YLYLTPC C C+ + + + SS
Sbjct: 360 NFTL-HGH-HDTLNTAYTTLVGCILSVVLVLIYLYLTPCRCWCRGVEKPSSHQGDSLSSS 417
Query: 444 ILSPGPASDASA-DERKAGAGKRVVFLEPLKDTAAGQNGKVRLFPSEAV-IAEGILKSTR 501
+LS P D A ++ G +RV FLEP GQNGK++ P + + E K R
Sbjct: 418 MLSTTPNHDPMAGGDKDDGFDRRVAFLEP-AGPGQGQNGKLK--PGNTLPVPEATGKGQR 474
Query: 502 GKSDSDSVNSVFSDTPFV 519
SD +SV+SVFSDTP V
Sbjct: 475 RMSDPESVSSVFSDTPIV 492
>gi|38454322 adhesion molecule with Ig-like domain 3 [Homo sapiens]
Length = 504
Score = 246 bits (627), Expect = 5e-65
Identities = 180/511 (35%), Positives = 251/511 (49%), Gaps = 35/511 (6%)
Query: 23 LLCLLMITVTVG------PGASGVCPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLS 76
LLC+L + + P A CP CICA D++SCT L VP L LDLS
Sbjct: 10 LLCMLRVGLGTPDSEGFPPRALHNCPYKCICAADLLSCTGLGLQDVPAELPAATADLDLS 69
Query: 77 YNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAV 136
+N + L W+ F +L L L HN + ++ G F L+ LDLSSN L+ +
Sbjct: 70 HNALQRLRPGWLAPLF-QLRALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRALGRHD 128
Query: 137 FQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMF 196
L LE LLL+NN + +LD AF GL L LYL N L F D ++ L+
Sbjct: 129 LDGLGALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASFSFD-HLHGLSATHLLT 187
Query: 197 LDVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLLVFWYRRHFSSVMDFKN 256
LD+S NR+ + + + +P G+YLH NP CDC LY LL W++R S+V DF
Sbjct: 188 LDLSSNRLGHISVPELAALPAFLKNGLYLHNNPLPCDCRLYHLLQRWHQRGLSAVRDFAR 247
Query: 257 DYTCRLWSDSRHSRQVLLLQDSFMNCSDSIINGSFRALGFIHEAQVGERLMVHCDSKTGN 316
+Y C + + F NCS + G R ++ A VG L ++C+ T
Sbjct: 248 EYVCLAFKVPASRVRFFQHSRVFENCSSAPALGLERPEEHLY-ALVGRSLRLYCN--TSV 304
Query: 317 ANTDFIWVGPDNRLLE-PDKEMENFYVFHNGSLVIESPRFEDAGVYSCIAMNKQRLLNET 375
WV P LL P + V +GSL I + + + AG++ C+A + N+T
Sbjct: 305 PAMRIAWVSPQQELLRAPGSRDGSIAVLADGSLAIGNVQEQHAGLFVCLATGPRLHHNQT 364
Query: 376 VDVTINVSNFTVSRSHAHEAFNTAFTTLAACVASIVLVLLYLYLTPCPC---KCKTKR-- 430
+ ++V +F EAFNT FTTL C +VLVLLYL+ PC C C+ +R
Sbjct: 365 HEYNVSV-HFPRPEP---EAFNTGFTTLLGCAVGLVLVLLYLFAPPCRCCRRACRCRRWP 420
Query: 431 -QKNMLHQSNAHSSILSPGPASDASADERKAGAGKRVVFLEPLKDTAAGQNGKVRLFPSE 489
+ L + +A SS+LS P A RKA K VVFLEP + G NG+V+L
Sbjct: 421 QTPSPLQELSAQSSVLSTTP---PDAPSRKASVHKHVVFLEPGR---RGLNGRVQL---- 470
Query: 490 AVIAEGILKSTRG---KSDSDSVNSVFSDTP 517
AV E L + G K+ S+S +S+ S+ P
Sbjct: 471 AVAEEFDLYNPGGLQLKAGSESASSIGSEGP 501
>gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]
Length = 2623
Score = 112 bits (281), Expect = 6e-25
Identities = 73/227 (32%), Positives = 126/227 (55%), Gaps = 16/227 (7%)
Query: 21 RELLCLLM----ITVTVGPGASGVCPTACICATDI-VSCTNKNLSKVPGNLFRLIKRLDL 75
R + CLL+ I + PG CP C C V CT + L+ +P ++ ++R++L
Sbjct: 6 RGITCLLVSFAVICLVATPGGKA-CPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINL 64
Query: 76 SYNR-IGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKN 134
YN + L+++++ ++ KL L+L N I +I +FS L+ L +S NK++ ++
Sbjct: 65 GYNSLVRLMETDFSGLT--KLELLMLHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQK 122
Query: 135 AVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGR-----F 189
F L+ L L + +N+I +++P F GL+ L+ ++L GN LT+ D +V F
Sbjct: 123 DTFYGLRSLTRLHMDHNNIEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIF 182
Query: 190 KLAELMFLDVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSL 236
K++ + FL +S N + S+P ++ +P L +YLHGNP+ CDC L
Sbjct: 183 KISFIKFLYLSDNFLTSLPQEMVSYMP--DLDSLYLHGNPWTCDCHL 227
Score = 47.8 bits (112), Expect = 2e-05
Identities = 33/115 (28%), Positives = 56/115 (48%), Gaps = 6/115 (5%)
Query: 255 KNDYTCRLWSDSRHSRQVLLLQDSFMNCSDSIINGSFRALGFIHEAQVGERLMVHCDSKT 314
+ Y C S + R+V++L S I S + E G++L+++C S T
Sbjct: 1912 RGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRT----EVNFGDKLLLNC-SAT 1966
Query: 315 GNANTDFIWVGPDNRLLEPDKEMENF-YVFHNGSLVIESPRFEDAGVYSCIAMNK 368
G +W P +++ + ++ +V+ NGSL I S +D+GVY C+A NK
Sbjct: 1967 GEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNK 2021
Score = 45.8 bits (107), Expect = 9e-05
Identities = 25/81 (30%), Positives = 39/81 (48%), Gaps = 1/81 (1%)
Query: 300 AQVGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAG 359
AQ+G+ ++C S GN + IW+ P+ + + + NGS +I EDAG
Sbjct: 2349 AQLGKSTALNC-SVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAG 2407
Query: 360 VYSCIAMNKQRLLNETVDVTI 380
Y C A NK + + V + I
Sbjct: 2408 KYRCAARNKVGYIEKLVILEI 2428
Score = 38.5 bits (88), Expect = 0.015
Identities = 25/78 (32%), Positives = 37/78 (47%), Gaps = 3/78 (3%)
Query: 290 SFRALGFIHEAQVGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLV 349
+++ G H +GE L + C S TG + WV P N +L + V +NG+L
Sbjct: 575 AYQENGIHHTVFIGETLDLPCHS-TGIPDASISWVIPGNNVLYQSSRDKK--VLNNGTLR 631
Query: 350 IESPRFEDAGVYSCIAMN 367
I +D G Y C+A N
Sbjct: 632 ILQVTPKDQGYYRCVAAN 649
Score = 37.0 bits (84), Expect = 0.044
Identities = 21/68 (30%), Positives = 34/68 (50%), Gaps = 5/68 (7%)
Query: 301 QVGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFH-NGSLVIESPRFEDAG 359
+ G+ ++ C+ TG+ W+ P N ++ + Y FH NGSL I + D+G
Sbjct: 2154 KAGDTAVLDCEV-TGDPKPKIFWLLPSNDMISFSIDR---YTFHANGSLTINKVKLLDSG 2209
Query: 360 VYSCIAMN 367
Y C+A N
Sbjct: 2210 EYVCVARN 2217
Score = 36.6 bits (83), Expect = 0.057
Identities = 20/70 (28%), Positives = 35/70 (50%), Gaps = 4/70 (5%)
Query: 301 QVGERLMVHCDSKTGNANTDFIWVGPDNRLLEP---DKEMENFYVFHNGSLVIESPRFED 357
+ G +HC + G + W PD+ LL ++ + + G+LVI++P+ D
Sbjct: 2541 RTGAAFQLHCVA-LGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSD 2599
Query: 358 AGVYSCIAMN 367
+G+Y C A N
Sbjct: 2600 SGIYKCTAKN 2609
Score = 35.0 bits (79), Expect = 0.17
Identities = 18/61 (29%), Positives = 29/61 (47%), Gaps = 1/61 (1%)
Query: 309 HCDSKT-GNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGVYSCIAMN 367
H D + G + + +W+ PDN L V NG+L I + R D+ + C+A N
Sbjct: 2258 HFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARN 2317
Query: 368 K 368
+
Sbjct: 2318 E 2318
Score = 34.7 bits (78), Expect = 0.22
Identities = 21/64 (32%), Positives = 31/64 (48%), Gaps = 2/64 (3%)
Query: 303 GERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMEN-FYVFHNGSLVIESPRFEDAGVY 361
GE L + C +K G WV D ++P + + ++F NG+L I + D G Y
Sbjct: 1857 GESLKLPCTAK-GTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTY 1915
Query: 362 SCIA 365
CIA
Sbjct: 1916 ECIA 1919
Score = 34.3 bits (77), Expect = 0.28
Identities = 24/78 (30%), Positives = 34/78 (43%), Gaps = 1/78 (1%)
Query: 303 GERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGVYS 362
GE L +HC S G + W P +++ + + + NG+LVI+ D G Y
Sbjct: 2447 GESLSLHCVSD-GIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYI 2505
Query: 363 CIAMNKQRLLNETVDVTI 380
C A N TV V I
Sbjct: 2506 CKAQNSVGHTLITVPVMI 2523
>gi|139948432 adlican [Homo sapiens]
Length = 2828
Score = 107 bits (267), Expect = 3e-23
Identities = 67/219 (30%), Positives = 111/219 (50%), Gaps = 9/219 (4%)
Query: 24 LCLLMITVTVGPGASGVCPTACIC-ATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGL 82
L +++I + P + CP C C V CT ++L+ VP + + ++R++L +N I
Sbjct: 10 LSVVLILLWGHPRVALACPHPCACYVPSEVHCTFRSLASVPAGIAKHVERINLGFNSIQA 69
Query: 83 LDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKV 142
L SE KL L++ N I SI G+ +L+ S NKL+ + Q L
Sbjct: 70 L-SETSFAGLTKLELLMIHGNEIPSIPDGALRDLSSLQVFKFSYNKLRVITGQTLQGLSN 128
Query: 143 LEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQ-----FPMDLYVGRFKLAELMFL 197
L L + +N I ++ P AF GL+ L+ L+L GN L Q F ++ F+L+ + L
Sbjct: 129 LMRLHIDHNKIEFIHPQAFNGLTSLRLLHLEGNLLHQLHPSTFSTFTFLDYFRLSTIRHL 188
Query: 198 DVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSL 236
++ N + ++P + +P L +YL GNP+ CDC +
Sbjct: 189 YLAENMVRTLPASMLRNMP--LLENLYLQGNPWTCDCEM 225
Score = 47.4 bits (111), Expect = 3e-05
Identities = 31/137 (22%), Positives = 71/137 (51%), Gaps = 10/137 (7%)
Query: 247 HFSSV-MDFKNDYTCRLWSDSRHSRQVLLLQDSFMNCSDSIINGSFRALGFIHEAQVGER 305
+F+ V M + DYTC +++++ + + ++ + +I N ++ A+ + G+
Sbjct: 2310 YFNEVGMREEGDYTC--FAENQVGKDEMRVRVKVVTAPATIRNKTYLAV----QVPYGDV 2363
Query: 306 LMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGVYSCIA 365
+ V C++K G W+ P N+++ E + ++ +G+L+I+ + D+G Y+C+
Sbjct: 2364 VTVACEAK-GEPMPKVTWLSPTNKVIPTSSE--KYQIYQDGTLLIQKAQRSDSGNYTCLV 2420
Query: 366 MNKQRLLNETVDVTINV 382
N +TV + +NV
Sbjct: 2421 RNSAGEDRKTVWIHVNV 2437
Score = 42.7 bits (99), Expect = 8e-04
Identities = 18/58 (31%), Positives = 33/58 (56%)
Query: 323 WVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGVYSCIAMNKQRLLNETVDVTI 380
W+ P+ R++ + Y+ NG+L I + D+G Y C+A+N+Q + TV +T+
Sbjct: 611 WILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGITV 668
Score = 41.2 bits (95), Expect = 0.002
Identities = 21/68 (30%), Positives = 33/68 (48%), Gaps = 1/68 (1%)
Query: 300 AQVGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAG 359
A G + ++C S G +WV P+ L+ ++++ FY +G L I DAG
Sbjct: 2554 AMAGHTISLNC-SAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAG 2612
Query: 360 VYSCIAMN 367
Y C+A N
Sbjct: 2613 AYRCVARN 2620
Score = 39.7 bits (91), Expect = 0.007
Identities = 21/67 (31%), Positives = 33/67 (49%), Gaps = 2/67 (2%)
Query: 302 VGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFH-NGSLVIESPRFEDAGV 360
+G+ + + C +K G W+ PD R+ + +E H N +L I+ F D GV
Sbjct: 1964 LGDTIAMECLAK-GTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGV 2022
Query: 361 YSCIAMN 367
Y C+A N
Sbjct: 2023 YKCVASN 2029
Score = 39.7 bits (91), Expect = 0.007
Identities = 28/101 (27%), Positives = 49/101 (48%), Gaps = 4/101 (3%)
Query: 299 EAQVGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMEN-FYVFHNGSLVIESPRFED 357
+ + G L + C S +G+ +W P R+++ ++ VF NG+LV++S +D
Sbjct: 2157 DVRYGGTLKLDC-SASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKD 2215
Query: 358 AGVYSCIAMNK--QRLLNETVDVTINVSNFTVSRSHAHEAF 396
AG Y C+A NK + VDV + + + H+ F
Sbjct: 2216 AGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVF 2256
Score = 38.9 bits (89), Expect = 0.012
Identities = 20/62 (32%), Positives = 31/62 (50%)
Query: 330 LLEPDKEMENFYVFHNGSLVIESPRFEDAGVYSCIAMNKQRLLNETVDVTINVSNFTVSR 389
L+ P+ ++ F V NG+LVI + +D G Y C A N L V +++ V +
Sbjct: 1895 LMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILA 1954
Query: 390 SH 391
SH
Sbjct: 1955 SH 1956
Score = 38.9 bits (89), Expect = 0.012
Identities = 23/79 (29%), Positives = 38/79 (48%), Gaps = 2/79 (2%)
Query: 303 GERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEME-NFYVFHNGSLVIESPRFEDAGVY 361
G + +HC +K + WV D + P + + N +VF NG+L I + +D+G Y
Sbjct: 2062 GLSIHIHCTAKAAPLPS-VRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRY 2120
Query: 362 SCIAMNKQRLLNETVDVTI 380
C+A N TV + +
Sbjct: 2121 ECVAANLVGSARRTVQLNV 2139
Score = 35.4 bits (80), Expect = 0.13
Identities = 35/149 (23%), Positives = 60/149 (40%), Gaps = 11/149 (7%)
Query: 298 HEAQVGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMEN-------FYVFHNGSLVI 350
H+ G L V C + TG N + W PD L+ + ++ + VF+NG+L
Sbjct: 2253 HKVFYGGDLKVDCVA-TGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYF 2311
Query: 351 ESPRFEDAGVYSCIAMNKQRLLNETVDVTINVSNFTVSRSHAHEAFNTAF--TTLAACVA 408
+ G Y+C A N+ V V + + T+ R+ + A + AC A
Sbjct: 2312 NEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATI-RNKTYLAVQVPYGDVVTVACEA 2370
Query: 409 SIVLVLLYLYLTPCPCKCKTKRQKNMLHQ 437
+ +L+P T +K ++Q
Sbjct: 2371 KGEPMPKVTWLSPTNKVIPTSSEKYQIYQ 2399
Score = 35.4 bits (80), Expect = 0.13
Identities = 29/113 (25%), Positives = 50/113 (44%), Gaps = 5/113 (4%)
Query: 257 DYTCRLWSDSRHSRQVLLLQDSFMNCSDSIINGSFRALGFIHE-AQVGERLMVHCDSKTG 315
+YTC + + + R+ + + +N ING+ + + E A G R ++ C ++ G
Sbjct: 2415 NYTCLVRNSAGEDRKTVWIH---VNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAE-G 2470
Query: 316 NANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGVYSCIAMNK 368
+W P+ +L V NGSL I S R D+ C+A N+
Sbjct: 2471 IPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNE 2523
Score = 33.5 bits (75), Expect = 0.49
Identities = 21/71 (29%), Positives = 34/71 (47%), Gaps = 3/71 (4%)
Query: 303 GERLMVHCDSKTGNANTDFIWVGPDNRLLEP--DKEMENFYVFHNGSLVIESPRFEDAGV 360
G + C+ K + + F WV PD +L+ D F + +G L I+S D+G+
Sbjct: 494 GGPCQLSCNVKASESPSIF-WVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGL 552
Query: 361 YSCIAMNKQRL 371
Y CIA + +
Sbjct: 553 YQCIAQVRDEM 563
Score = 31.2 bits (69), Expect = 2.4
Identities = 20/68 (29%), Positives = 30/68 (44%), Gaps = 4/68 (5%)
Query: 303 GERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEME---NFYVFHNGSLVIESPRFEDAG 359
G + ++C + G D W PD L+ + N ++ GSL I+ DAG
Sbjct: 2748 GNTVKLNCMAM-GIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAG 2806
Query: 360 VYSCIAMN 367
Y C+A N
Sbjct: 2807 FYKCMAKN 2814
Score = 29.6 bits (65), Expect = 7.0
Identities = 17/61 (27%), Positives = 25/61 (40%), Gaps = 1/61 (1%)
Query: 303 GERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGVYS 362
GE L + C + G F W P+ LE + + + NG+L + D G Y
Sbjct: 2652 GETLKLPC-TPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYV 2710
Query: 363 C 363
C
Sbjct: 2711 C 2711
>gi|126517478 peroxidasin homolog-like [Homo sapiens]
Length = 1463
Score = 105 bits (263), Expect = 8e-23
Identities = 100/349 (28%), Positives = 150/349 (42%), Gaps = 48/349 (13%)
Query: 23 LLCLLMITVTVGPGASGV-CPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIG 81
L C + + G G+ CP+ C+C V C + L +P + + LDL +NRI
Sbjct: 5 LFCWTTLFLLAGWCLPGLPCPSRCLCFKSTVRCMHLMLDHIP-QVPQQTTVLDLRFNRIR 63
Query: 82 LLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELK 141
+ LNTL+L +N+I IS +F NL L L N++ + F+ L
Sbjct: 64 EIPGSAFK-KLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKGLI 122
Query: 142 VLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSY 201
LE L ++ N + L P FG L +L++L+L N L++ P G F
Sbjct: 123 SLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIP----AGSFS----------- 167
Query: 202 NRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSL--LVFWYRRHFSSVMDFKNDYT 259
NL K+LR L N VCDC L L L+ + +H + +Y
Sbjct: 168 -----------NLDSLKRLR---LDSNALVCDCDLMWLGELLQGFAQHGHTQAAATCEYP 213
Query: 260 CRLWSDSRHSRQVLLLQDSFMNCSDSIINGSFRALGFIHEAQVGERLMVHCDSKTGNANT 319
RL H R V + NC I + + E G + C ++ GN
Sbjct: 214 RRL-----HGRAVASVTVEEFNCQSPRITFEPQDV----EVPSGNTVYFTCRAE-GNPKP 263
Query: 320 DFIWVGPDNRL-LEPDKEMENFYVFHNGSLVIESPRFEDAGVYSCIAMN 367
+ IW+ ++ L LE D + VF +G+L+I + R D GVY C+A N
Sbjct: 264 EIIWIHNNHSLDLEDDTRLN---VFDDGTLMIRNTRESDQGVYQCMARN 309
Score = 31.2 bits (69), Expect = 2.4
Identities = 21/80 (26%), Positives = 35/80 (43%), Gaps = 5/80 (6%)
Query: 301 QVGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGV 360
+VG+ + + C ++ G W ++ E K F+V G+L I F D G
Sbjct: 523 EVGKNINISCHAQ-GEPQPIITWNKEGVQITESGK----FHVDDEGTLTIYDAGFPDQGR 577
Query: 361 YSCIAMNKQRLLNETVDVTI 380
Y C+A N L + +T+
Sbjct: 578 YECVARNSFGLAVTNMFLTV 597
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 97.4 bits (241), Expect = 3e-20
Identities = 93/365 (25%), Positives = 150/365 (41%), Gaps = 66/365 (18%)
Query: 18 PGCRELLCLLMI-------TVTVGPGASGVCPTACICATDIVSCTNKNLSKVPGNLFRLI 70
PG R LL L++ V PGA CP+ C+C V C + L
Sbjct: 8 PGRRCLLALVLFCAWGTLAVVAQKPGAG--CPSRCLCFRTTVRCMHLLL----------- 54
Query: 71 KRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLK 130
E +P + + L LR N I I G+F NL L L++N++K
Sbjct: 55 ---------------EAVPAVAPQTSILDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIK 99
Query: 131 TVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFK 190
+ + F++L+ L+ L LY N I +D AF GL+ L++LYL N + D + K
Sbjct: 100 RIPSGAFEDLENLKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPK 159
Query: 191 LAELMFLDVSYNRIPSMPMHHINLVPG-----KQLRGIYLHGNPFVCDCSLYSLLVFWYR 245
L L + NRI +LVPG + ++ + L N CDC + W
Sbjct: 160 LERLF---LHNNRI-------THLVPGTFNHLESMKRLRLDSNTLHCDCE-----ILWLA 204
Query: 246 RHFSSVMDFKNDYTCRLWSDSR--HSRQVLLLQDSFMNCSDSIINGSFRALGFIHEAQVG 303
+ + N + R R V + +NC I + + G
Sbjct: 205 DLLKTYAESGNAQAAAICEYPRRIQGRSVATITPEELNCERPRITSEPQDA----DVTSG 260
Query: 304 ERLMVHCDSKTGNANTDFIWVGPDNRL-LEPDKEMENFYVFHNGSLVIESPRFEDAGVYS 362
+ C ++ GN + IW+ +N L ++ D + + +G+L+I++ + D G+Y
Sbjct: 261 NTVYFTCRAE-GNPKPEIIWLRNNNELSMKTDSRLN---LLDDGTLMIQNTQETDQGIYQ 316
Query: 363 CIAMN 367
C+A N
Sbjct: 317 CMAKN 321
Score = 39.7 bits (91), Expect = 0.007
Identities = 81/366 (22%), Positives = 135/366 (36%), Gaps = 55/366 (15%)
Query: 56 NKNLSKVPGNLFRLIKRLDLSY---NRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGS 112
N + ++P F ++ L Y N I +D + A L L L N I ++ S
Sbjct: 95 NNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQAFK-GLASLEQLYLHFNQIETLDPDS 153
Query: 113 FSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYL 172
F P L+ L L +N++ + F L+ ++ L L +N + + D L+ L K Y
Sbjct: 154 FQHLPKLERLFLHNNRITHLVPGTFNHLESMKRLRLDSNTL-HCDCEILW-LADLLKTYA 211
Query: 173 -SGNF----LTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQLRGIYLHG 227
SGN + ++P + L+ RI S P G
Sbjct: 212 ESGNAQAAAICEYPRRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEG 271
Query: 228 NPFVCDCSLYSLLVFWYRRHFSSVMDFKNDYTCRLWSDSRHSRQVLLLQDS------FMN 281
NP + W R + + + K D L D L++Q++
Sbjct: 272 NP--------KPEIIWLRNN--NELSMKTDSRLNLLDDG-----TLMIQNTQETDQGIYQ 316
Query: 282 CSDSIING-------SFRALG------FIHEAQ-----VGERLMVHCDSKTGNANTDFIW 323
C + G + R G F+ + Q VGE + + C S TG+ W
Sbjct: 317 CMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLEC-SATGHPPPRISW 375
Query: 324 VGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGVYSCIAMNKQRLLNETVDVTIN-V 382
D L D + + +G L I++ D+G Y+C A N ++ T + + +
Sbjct: 376 TRGDRTPLPVDPRVN---ITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQAL 432
Query: 383 SNFTVS 388
FTV+
Sbjct: 433 PQFTVT 438
Score = 29.6 bits (65), Expect = 7.0
Identities = 24/90 (26%), Positives = 41/90 (45%), Gaps = 7/90 (7%)
Query: 301 QVGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGV 360
+VG + + C S+ G W ++ E K F++ G L I DAG
Sbjct: 537 EVGANVQLPCSSQ-GEPEPAITWNKDGVQVTESGK----FHISPEGFLTINDVGPADAGR 591
Query: 361 YSCIAMNKQRLLNETVDVTINVSNFTVSRS 390
Y C+A N + ++ +++NV + VSR+
Sbjct: 592 YECVARNTIGSASVSMVLSVNVPD--VSRN 619
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 95.9 bits (237), Expect = 8e-20
Identities = 68/193 (35%), Positives = 98/193 (50%), Gaps = 11/193 (5%)
Query: 41 CPTACICATD-----IVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKL 95
CPT C C D V C++ LS++P NL LDLS N I L +P S L
Sbjct: 34 CPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLP-SLRFL 92
Query: 96 NTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISY 155
L L N +T I G+F+ +LK L L +N+L+ V Q L+ L+ L L NHISY
Sbjct: 93 EELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISY 152
Query: 156 LDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLV 215
+ PS F GL L+ L+L N LT+ P+ + L+ L + ++ N+I +P + +
Sbjct: 153 VPPSCFSGLHSLRHLWLDDNALTEIPVQAF---RSLSALQAMTLALNKIHHIPDYAFGNL 209
Query: 216 PGKQLRGIYLHGN 228
L ++LH N
Sbjct: 210 --SSLVVLHLHNN 220
Score = 54.3 bits (129), Expect = 3e-07
Identities = 54/185 (29%), Positives = 80/185 (43%), Gaps = 16/185 (8%)
Query: 51 IVSCTNKNLSKVPGNLF---RLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLI---LRHNN 104
++ N L VP R ++ L L N I + P F+ L++L L N
Sbjct: 118 VLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVP----PSCFSGLHSLRHLWLDDNA 173
Query: 105 ITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGL 164
+T I +F + L+ + L+ NK+ + + F L L VL L+NN I L F GL
Sbjct: 174 LTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGL 233
Query: 165 SQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQLRGIY 224
L+ L L+ N L +FP + L+ L L N I S+P V L I+
Sbjct: 234 HSLETLDLNYNNLDEFPTAIRT----LSNLKELGFHSNNIRSIP--EKAFVGNPSLITIH 287
Query: 225 LHGNP 229
+ NP
Sbjct: 288 FYDNP 292
Score = 52.0 bits (123), Expect = 1e-06
Identities = 51/158 (32%), Positives = 76/158 (48%), Gaps = 9/158 (5%)
Query: 64 GNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLD 123
GNL L+ L L NRI L + L TL L +NN+ T + T NLK L
Sbjct: 207 GNLSSLVV-LHLHNNRIHSLGKKCFD-GLHSLETLDLNYNNLDEFPT-AIRTLSNLKELG 263
Query: 124 LSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSG-NFLTQFPM 182
SN ++++ F L + Y+N I ++ SAF L +L+ L L+G + +T+FP
Sbjct: 264 FHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFP- 322
Query: 183 DLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQL 220
DL A L L ++ +I S+P N +P Q+
Sbjct: 323 DL----TGTANLESLTLTGAQISSLPQTVCNQLPNLQV 356
Score = 50.1 bits (118), Expect = 5e-06
Identities = 33/88 (37%), Positives = 47/88 (53%), Gaps = 2/88 (2%)
Query: 95 LNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHIS 154
L L L +N + + SFS L+ +DL N++ +K FQ+L L L L N I+
Sbjct: 354 LQVLDLSYNLLEDLP--SFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIA 411
Query: 155 YLDPSAFGGLSQLQKLYLSGNFLTQFPM 182
+ P+AF L L KL LS N L+ FP+
Sbjct: 412 IIHPNAFSTLPSLIKLDLSSNLLSSFPI 439
Score = 44.7 bits (104), Expect = 2e-04
Identities = 40/131 (30%), Positives = 62/131 (47%), Gaps = 9/131 (6%)
Query: 52 VSCTNKNLSKVPG---NLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSI 108
++ T +S +P N ++ LDLSYN + L S + KL + LRHN I I
Sbjct: 333 LTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSV---CQKLQKIDLRHNEIYEI 389
Query: 109 STGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQ 168
+F +L+ L+L+ NK+ + F L L L L +N +S + GL+ L+
Sbjct: 390 KVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLK 449
Query: 169 KLYLSGNFLTQ 179
L+GN Q
Sbjct: 450 ---LTGNHALQ 457
Score = 43.9 bits (102), Expect = 4e-04
Identities = 26/93 (27%), Positives = 44/93 (47%)
Query: 151 NHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMH 210
N+IS L P+ L L++L L+GN LT P + G + L LM + +P+ +
Sbjct: 76 NNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQ 135
Query: 211 HINLVPGKQLRGIYLHGNPFVCDCSLYSLLVFW 243
++ + +L ++ P C L+SL W
Sbjct: 136 NLRSLQSLRLDANHISYVPPSCFSGLHSLRHLW 168
>gi|31542244 leucine rich repeat and fibronectin type III domain
containing 5 [Homo sapiens]
Length = 719
Score = 94.7 bits (234), Expect = 2e-19
Identities = 102/417 (24%), Positives = 170/417 (40%), Gaps = 77/417 (18%)
Query: 23 LLCLLMITVTVGPGASGVCPTACICATDIVS------CTNKNLSKVPGNLFRLIKRLDLS 76
L L +I + V + +CP C+C I+S C K L VP N+ R L L+
Sbjct: 5 LFYLFLIGIAV---KAQICPKRCVC--QILSPNLATLCAKKGLLFVPPNIDRRTVELRLA 59
Query: 77 YNRIGLLDSEWIPVSFAKLNTLI---LRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVK 133
N + + + FA + +L+ L N I+ I+ +F+ NL+ L L+SN+L +
Sbjct: 60 DNFVTNIKRK----DFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKIT 115
Query: 134 NAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAE 193
N +F L L L+L NN ++ + +AF + L++L LS N L P D K+
Sbjct: 116 NDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVE---KMVS 172
Query: 194 LMFLDVSYNRIPSMP---------MHHINLVPGKQLR----------------------- 221
L L + +N I ++P M +++ K +
Sbjct: 173 LHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPST 232
Query: 222 -GIYLHGNPFVCDCSLYSLLVFWYRRHFSSVMDFKNDYTCRLWSDSRHSRQVLLLQDSFM 280
+ GNP C+C L W RR + ++D R + +
Sbjct: 233 FALSFGGNPLHCNCEL-----LWLRR-----LSREDDLETCASPPLLTGRYFWSIPEEEF 282
Query: 281 NCSDSIINGSFRALGFIHEAQV--GERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEME 338
C +I HE +V G+R + C ++ G+ W+ P+ +L+
Sbjct: 283 LCEPPLIT------RHTHEMRVLEGQRATLRCKAR-GDPEPAIHWISPEGKLI---SNAT 332
Query: 339 NFYVFHNGSLVIESPRFEDAGVYSCIAMNKQRLLNETVDV-TINVSNFTVSRSHAHE 394
V+ NG+L I +D G ++CIA N + VD+ I + + S +H HE
Sbjct: 333 RSLVYDNGTLDILITTVKDTGAFTCIASNPAGEATQIVDLHIIKLPHLLNSTNHIHE 389
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 94.0 bits (232), Expect = 3e-19
Identities = 74/219 (33%), Positives = 104/219 (47%), Gaps = 30/219 (13%)
Query: 12 LGAVVRPGCRELLCLLMIT---VTVGPGASGVCPTACICATDIVSCTNKNLSKVPGNLFR 68
LGA R C LL LL++ VT G C AC CA D + C + L+ +PG+L
Sbjct: 9 LGAPRRSPCLLLLWLLLLRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLAALPGDLPS 68
Query: 69 LIKRLDLSYNRIGLLDS---EWIP-------------------VSFAKLNTLILRHNNIT 106
+ L+LSYN++ +D E +P + + + +L L+HN I
Sbjct: 69 WTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLQHNKIR 128
Query: 107 SISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQ 166
S+ +L+ LDLS N + V+N F ++ L L N I L+ AF GLS+
Sbjct: 129 SVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSR 188
Query: 167 -LQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRI 204
L L LS N +TQ P V FKL L LD++ NRI
Sbjct: 189 SLLTLRLSKNRITQLP----VRAFKLPRLTQLDLNRNRI 223
Score = 68.9 bits (167), Expect = 1e-11
Identities = 53/158 (33%), Positives = 78/158 (49%), Gaps = 4/158 (2%)
Query: 50 DIVSCTNKNLSKVPGNLFRL---IKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNIT 106
+++ + N+++V F IK L+L+ NRIG L+ L TL L N IT
Sbjct: 142 EVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRIT 201
Query: 107 SISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQ 166
+ +F P L LDL+ N+++ ++ FQ L LEVL L N+IS L AF GLS+
Sbjct: 202 QLPVRAFKL-PRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSK 260
Query: 167 LQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRI 204
+ L+L N L + G L +L + S RI
Sbjct: 261 MHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARI 298
Score = 67.4 bits (163), Expect = 3e-11
Identities = 85/321 (26%), Positives = 136/321 (42%), Gaps = 33/321 (10%)
Query: 64 GNLFRL--IKRLDLSYNRIGLLDSE-WIPVSFA-KLNTLILRHNNITSISTGSFSTTPNL 119
G+L+ L + +L LS N I + + W SF KL+ L+L NN+T + S + +L
Sbjct: 277 GSLYGLTALHQLHLSNNSIARIHRKGW---SFCQKLHELVLSFNNLTRLDEESLAELSSL 333
Query: 120 KCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYL---DPSAFGGLSQLQKLYLSGNF 176
L LS N + + F+ L+ L VL L +N IS AF GL L KL L GN
Sbjct: 334 SVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNK 393
Query: 177 LTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSL 236
+ + G L L L++ N I S+ V K L+ +++ + F+CDC L
Sbjct: 394 IKSVAKRAFSG---LEGLEHLNLGGNAIRSVQFD--AFVKMKNLKELHISSDSFLCDCQL 448
Query: 237 YSLLVFWYRRHFSSVMDFKNDYTCRLWSDSRHSRQVLLLQDSFMNCSDSIINGSFRALGF 296
L + R + + TC +S + + + C D +
Sbjct: 449 KWLPPWLIGRMLQAFV----TATC-AHPESLKGQSIFSVPPESFVC-DDFLKPQIITQPE 502
Query: 297 IHEAQVGERLMVHCDSKTGNAN-TDFIWVGPDNRLLEPDKEMENFYVFH--NGSLV---- 349
A VG+ + C + + +++ F W DN +L + +MENF H +G ++
Sbjct: 503 TTMAMVGKDIRFTCSAASSSSSPMTFAW-KKDNEVL-TNADMENFVHVHAQDGEVMEYTT 560
Query: 350 ---IESPRFEDAGVYSCIAMN 367
+ F G Y C+ N
Sbjct: 561 ILHLRQVTFGHEGRYQCVITN 581
Score = 36.6 bits (83), Expect = 0.057
Identities = 76/383 (19%), Positives = 144/383 (37%), Gaps = 71/383 (18%)
Query: 46 ICATDIVSCTNKNLSKVPGNLF---RLIKRLDLSYNRIG--LLDSEWIPVSFAKLNTLIL 100
+ + ++ ++ ++S + F R ++ LDL +N I + D+ L+ L L
Sbjct: 330 LSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTL 389
Query: 101 RHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVL------LLYNNHIS 154
N I S++ +FS L+ L+L N +++V+ F ++K L+ L L + +
Sbjct: 390 FGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDSFLCDCQLK 449
Query: 155 YLDPSAFGGLSQL-------QKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSM 207
+L P G + Q L G + P + +V D +I +
Sbjct: 450 WLPPWLIGRMLQAFVTATCAHPESLKGQSIFSVPPESFVCD---------DFLKPQIITQ 500
Query: 208 PMHHINLVPGKQLRGIYLHGNPFVCDC--SLYSLLVFWYRRHFSSVM--DFKN------- 256
P + +V GK +R F C S S + F +++ + D +N
Sbjct: 501 PETTMAMV-GKDIR--------FTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQ 551
Query: 257 DYTCRLWSDSRHSRQVLLLQDSFMNCSDSIINGSFRALGFIHEAQVGERLM--------- 307
D ++ H RQV + C +I F + + H+A++ ++
Sbjct: 552 DGEVMEYTTILHLRQVTFGHEGRYQC---VITNHFGST-YSHKARLTVNVLPSFTKTPHD 607
Query: 308 ----------VHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFED 357
+ C + TG+ N W +E + + I + +D
Sbjct: 608 ITIRTTTMARLEC-AATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDD 666
Query: 358 AGVYSCIAMNKQRLLNETVDVTI 380
AGVYSC A N ++ +T+
Sbjct: 667 AGVYSCTAQNSAGSISANATLTV 689
>gi|51317373 netrin-G1 ligand [Homo sapiens]
Length = 640
Score = 92.4 bits (228), Expect = 9e-19
Identities = 98/438 (22%), Positives = 166/438 (37%), Gaps = 89/438 (20%)
Query: 23 LLCLLMITVTVGPGASGVCPTACICATDI--VSCTNKNLSKVPGNLFRLIKRLDLSYNRI 80
+L L + V G + CP+ C C+ V C KNL +VP + + L+L N+I
Sbjct: 29 VLLALQLLVVAGLVRAQTCPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQI 88
Query: 81 GLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQEL 140
++ L L L N+I +I G+F+ NL L+L N+L T+ N F L
Sbjct: 89 QIIKVNSFK-HLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYL 147
Query: 141 KVLEVLLLYNN-------------------------HISYLDPSAFGGLS---------- 165
L+ L L NN +SY+ AF GLS
Sbjct: 148 SKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMC 207
Query: 166 ------------QLQKLYLSGNFLTQFPMDLYVGRFKLAELMF----------------- 196
+L +L LSGN L+ + G L +L
Sbjct: 208 NLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQ 267
Query: 197 ----LDVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLLVFWYRRHFSSVM 252
+++++N + +P H P L I+LH NP+ C+C + L + W+ + +
Sbjct: 268 SLVEINLAHNNLTLLP--HDLFTPLHHLERIHLHHNPWNCNCDI--LWLSWWIKDMAP-- 321
Query: 253 DFKNDYTCRLWS--DSRHSRQVLLLQDSFMNCSDSIINGSFRALGFIHEAQVGERLMVHC 310
N C + + R + L ++ C +I + + V E +
Sbjct: 322 --SNTACCARCNTPPNLKGRYIGELDQNYFTCYAPVI------VEPPADLNVTEGMAAEL 373
Query: 311 DSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGVYSCIAMNKQR 370
+ + T W+ P+ ++ V +G+L + +D G+Y+C+ N
Sbjct: 374 KCRASTSLTSVSWITPNGTVMTHGAYKVRIAVLSDGTLNFTNVTVQDTGMYTCMVSNS-- 431
Query: 371 LLNETVDVTINVSNFTVS 388
+ N T T+NV+ T +
Sbjct: 432 VGNTTASATLNVTAATTT 449
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 90.9 bits (224), Expect = 3e-18
Identities = 64/206 (31%), Positives = 95/206 (46%), Gaps = 30/206 (14%)
Query: 37 ASGVCPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLN 96
+SG CP C C+ IV C K L+ +P NL P + ++
Sbjct: 278 SSGSCPAMCTCSNGIVDCRGKGLTAIPANL----------------------PETMTEIR 315
Query: 97 TLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYL 156
L N I SI G+FS L+ +DLS+N++ + FQ L+ L L+LY N I+ L
Sbjct: 316 ---LELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDL 372
Query: 157 DPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVP 216
FGGL LQ L L+ N + D + L L L + N+I S+ +
Sbjct: 373 PRGVFGGLYTLQLLLLNANKINCIRPDAFQ---DLQNLSLLSLYDNKIQSLAKGTFTSL- 428
Query: 217 GKQLRGIYLHGNPFVCDCSLYSLLVF 242
+ ++ ++L NPF+CDC+L L F
Sbjct: 429 -RAIQTLHLAQNPFICDCNLKWLADF 453
Score = 84.3 bits (207), Expect = 2e-16
Identities = 70/227 (30%), Positives = 103/227 (45%), Gaps = 10/227 (4%)
Query: 21 RELLCLLMITVTVGPGASGVCPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRI 80
R L LL+ GAS CP C C V C L +P N+ R +RL+L+ N I
Sbjct: 15 RPELWLLLWAAAWRLGASA-CPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNNI 73
Query: 81 GLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQEL 140
+ +L L L N I ++ G+F L+ L L+ N+L + +FQ
Sbjct: 74 TRIHKNDF-AGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNN 132
Query: 141 KVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFK-LAELMFLDV 199
+ L L L N I + AF G + L+ L L N ++ + G F+ L L L +
Sbjct: 133 QALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQIS----CIEEGAFRALRGLEVLTL 188
Query: 200 SYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLLVFWYRR 246
+ N I ++P+ N +P +LR LH N CDC L + L W R+
Sbjct: 189 NNNNITTIPVSSFNHMP--KLRTFRLHSNHLFCDCHL-AWLSQWLRQ 232
Score = 79.0 bits (193), Expect = 1e-14
Identities = 41/139 (29%), Positives = 77/139 (55%)
Query: 40 VCPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLI 99
VCP C C ++V C++ L+K+P + + L L+ N I +L++ + L +
Sbjct: 512 VCPHKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKIN 571
Query: 100 LRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPS 159
L +N ++ I G+F ++ L L++N+L+++++ +F+ L L L+L NN IS +
Sbjct: 572 LSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHND 631
Query: 160 AFGGLSQLQKLYLSGNFLT 178
+F GL ++ L L N +T
Sbjct: 632 SFTGLRNVRLLSLYDNQIT 650
Score = 71.6 bits (174), Expect = 2e-12
Identities = 43/135 (31%), Positives = 67/135 (49%), Gaps = 2/135 (1%)
Query: 41 CPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLIL 100
CP C C +V C+NK+L +P + + + L L N+ L+ + +F L + L
Sbjct: 734 CPQECACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPGQL--STFKYLQLVDL 791
Query: 101 RHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSA 160
+N I+S+S SF+ L L LS N L+ + FQ L+ L +L L+ N IS L
Sbjct: 792 SNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGI 851
Query: 161 FGGLSQLQKLYLSGN 175
F ++ L L + N
Sbjct: 852 FADVTSLSHLAIGAN 866
>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
Length = 713
Score = 89.4 bits (220), Expect = 7e-18
Identities = 103/449 (22%), Positives = 171/449 (38%), Gaps = 106/449 (23%)
Query: 23 LLCLLMITVTVGPGASGV---------------CPTACICATDI--VSCTNKNLSKVPGN 65
LL L + + +G G GV CP AC C+ V CT ++L++VP +
Sbjct: 24 LLFLWLFSPPLGAGGGGVAVTSAAGGGSPPATSCPVACSCSNQASRVICTRRDLAEVPAS 83
Query: 66 L---------------------FRLIKRLDL--------------------SYNRIGLLD 84
+ F+ ++ L++ S N + L D
Sbjct: 84 IPVNTRYLNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFD 143
Query: 85 SEWIPVS------FAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSS-NKLKTVKNAVF 137
+ V +KL L LR+N I SI + +F+ P+L+ LDL +L+ + A F
Sbjct: 144 NRLTTVPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAF 203
Query: 138 Q----------------------ELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGN 175
+ L LE L L N + + P +F GL+ L+KL+L
Sbjct: 204 EGLVNLRYLNLGMCNLKDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHA 263
Query: 176 FLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCS 235
+ + + L E L++S+N + S+P H P +L ++L+ NP+ C+C
Sbjct: 264 QVATIERNAFDDLKSLEE---LNLSHNNLMSLP--HDLFTPLHRLERVHLNHNPWHCNCD 318
Query: 236 LYSLLVFWYRRHFSSVMDFKNDYTCRLWSDS-RHSRQVLLLQDSFMNCSDSIINGSFRAL 294
V W + R + + R + L S C +I +
Sbjct: 319 -----VLWLSWWLKETVPSNTTCCARCHAPAGLKGRYIGELDQSHFTCYAPVI------V 367
Query: 295 GFIHEAQVGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPR 354
+ V E + +TG + T W+ P+ L+ V H+G+L +
Sbjct: 368 EPPTDLNVTEGMAAELKCRTGTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGTLNFTNVT 427
Query: 355 FEDAGVYSCIAMNKQRLLNETVDVTINVS 383
+D G Y+C+ N N T T+NVS
Sbjct: 428 VQDTGQYTCMVTNSAG--NTTASATLNVS 454
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 86.7 bits (213), Expect = 5e-17
Identities = 59/196 (30%), Positives = 92/196 (46%), Gaps = 30/196 (15%)
Query: 41 CPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLIL 100
CP AC C+ +IV C K L+++P NL I + L N I +
Sbjct: 273 CPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKV------------------ 314
Query: 101 RHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSA 160
I G+FS L+ +DLS+N++ + FQ L+ L L+LY N I+ L S
Sbjct: 315 -------IPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSL 367
Query: 161 FGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQL 220
F GL LQ L L+ N + +D + L L L + N++ ++ + P + +
Sbjct: 368 FEGLFSLQLLLLNANKINCLRVDAFQ---DLHNLNLLSLYDNKLQTIAKGTFS--PLRAI 422
Query: 221 RGIYLHGNPFVCDCSL 236
+ ++L NPF+CDC L
Sbjct: 423 QTMHLAQNPFICDCHL 438
Score = 82.4 bits (202), Expect = 9e-16
Identities = 68/244 (27%), Positives = 98/244 (40%), Gaps = 49/244 (20%)
Query: 24 LCLLMITVTVGPGASGVCPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLL 83
L L ++ + A CP C C+ V C L VP N+ R +RLDL+
Sbjct: 11 LSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDLN------- 63
Query: 84 DSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVL 143
NNIT I+ F+ +L+ L L NK+ T++ FQ+LK L
Sbjct: 64 ------------------GNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKEL 105
Query: 144 EVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRF-------------- 189
E L L NH+ F G ++L +L LS N + P + G
Sbjct: 106 ERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISC 165
Query: 190 -------KLAELMFLDVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLLVF 242
L +L L ++ N I + + N +P +LR LH N CDC L + L
Sbjct: 166 IEDGAFRALRDLEVLTLNNNNITRLSVASFNHMP--KLRTFRLHSNNLYCDCHL-AWLSD 222
Query: 243 WYRR 246
W R+
Sbjct: 223 WLRQ 226
Score = 77.4 bits (189), Expect = 3e-14
Identities = 47/135 (34%), Positives = 68/135 (50%), Gaps = 2/135 (1%)
Query: 41 CPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLIL 100
CPT C C +V C+NK L +P + R + L L N+ L+ E ++ L + L
Sbjct: 727 CPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELS--NYKHLTLIDL 784
Query: 101 RHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSA 160
+N I+++S SFS L L LS N+L+ + F LK L +L L+ N IS + A
Sbjct: 785 SNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGA 844
Query: 161 FGGLSQLQKLYLSGN 175
F LS L L + N
Sbjct: 845 FNDLSALSHLAIGAN 859
Score = 75.9 bits (185), Expect = 9e-14
Identities = 46/162 (28%), Positives = 83/162 (51%)
Query: 41 CPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLIL 100
CP C C V C+N+ L+K+P ++ + L L+ N +L++ I +L +
Sbjct: 506 CPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINF 565
Query: 101 RHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSA 160
+N IT I G+F + + L+SN+L+ V++ +F+ L+ L+ L+L +N I+ + +
Sbjct: 566 SNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGNDS 625
Query: 161 FGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYN 202
F GLS ++ L L N +T + L+ L L +N
Sbjct: 626 FIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFN 667
>gi|30425553 reticulon 4 receptor-like 1 [Homo sapiens]
Length = 441
Score = 85.5 bits (210), Expect = 1e-16
Identities = 66/184 (35%), Positives = 91/184 (49%), Gaps = 10/184 (5%)
Query: 15 VVRPGCRELLCLLMITVTVGPGASGVCPTACIC--ATDIVSCTNKNLSKVPGNLFRLIKR 72
++R GC L LL++ + G G CP C+C A VSC N + +P + +R
Sbjct: 1 MLRKGCCVELLLLLVAAELPLG--GGCPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSER 58
Query: 73 LDLSYNRIGLLDSEWIPVSFAK-LNTLILRHNNITSISTGSFSTTPNLKCLDLSSNK-LK 130
+ L NRIGLL P F+ + TL + NNIT I +F +L+ LDL N+ L+
Sbjct: 59 VFLQNNRIGLLQ----PGHFSPAMVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLR 114
Query: 131 TVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFK 190
T+ FQ L L L LY +S L FGGL LQ LYL N + D++V
Sbjct: 115 TLAPETFQGLVKLHALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVN 174
Query: 191 LAEL 194
L+ L
Sbjct: 175 LSHL 178
Score = 54.3 bits (129), Expect = 3e-07
Identities = 40/120 (33%), Positives = 57/120 (47%), Gaps = 4/120 (3%)
Query: 59 LSKVPGNLFRLIKRLDLSY---NRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFST 115
LS +P +F + L Y N I L + I V L+ L L N + S+ G+F
Sbjct: 137 LSALPAGVFGGLHSLQYLYLQDNHIEYLQDD-IFVDLVNLSHLFLHGNKLWSLGPGTFRG 195
Query: 116 TPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGN 175
NL L L N+L+ V + F +L+ L L L+NN +S L L L+ L L+GN
Sbjct: 196 LVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGN 255
Score = 46.6 bits (109), Expect = 6e-05
Identities = 50/190 (26%), Positives = 77/190 (40%), Gaps = 36/190 (18%)
Query: 95 LNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHIS 154
L L L+ N+I + F NL L L NKL ++ F+ L L+ LLL+ N +
Sbjct: 151 LQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRGLVNLDRLLLHENQLQ 210
Query: 155 YLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINL 214
++ AF L +L L+L N L++ + L
Sbjct: 211 WVHHKAFHDLRRLTTLFLFNNSLSELQGEC-----------------------------L 241
Query: 215 VPGKQLRGIYLHGNPFVCDCSLYSLLVFWYRRHFSSVMDFKNDYTCRLWSDSRHSRQVLL 274
P L + L+GNP+ C C SL W +R S + C + RH + + L
Sbjct: 242 APLGALEFLRLNGNPWDCGCRARSLWE-WLQRFRGS----SSAVPC-VSPGLRHGQDLKL 295
Query: 275 LQ-DSFMNCS 283
L+ + F NC+
Sbjct: 296 LRAEDFRNCT 305
>gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo
sapiens]
Length = 516
Score = 84.3 bits (207), Expect = 2e-16
Identities = 69/218 (31%), Positives = 104/218 (47%), Gaps = 16/218 (7%)
Query: 35 PGASGVCPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAK 94
P CP C C + C ++ VP + L L +N I L+ + SF++
Sbjct: 28 PALGMACPPKCRCEKLLFYCDSQGFHSVPNATDKGSLGLSLRHNHITELERDQF-ASFSQ 86
Query: 95 LNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHIS 154
L L L HN I+++ +F LK L LSSNK+ + N F +L L+ L L N +S
Sbjct: 87 LTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLS 146
Query: 155 YLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMH-HIN 213
L P F GL +LQ L+L N L P+ L+ + L FLD+S NR+ S+ +
Sbjct: 147 SLHPELFYGLRKLQTLHLRSNSLRTIPVRLF---WDCRSLEFLDLSTNRLRSLARNGFAG 203
Query: 214 LVPGKQLRGIYLHGNP--------FVCDCSLYSLLVFW 243
L+ +LR ++L N F+ SL++L + W
Sbjct: 204 LI---KLRELHLEHNQLTKINFAHFLRLSSLHTLFLQW 238
Score = 57.0 bits (136), Expect = 4e-08
Identities = 58/212 (27%), Positives = 96/212 (45%), Gaps = 23/212 (10%)
Query: 70 IKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKL 129
++ LDLS+N++ L E KL TL LR N++ +I F +L+ LDLS+N+L
Sbjct: 135 LQNLDLSFNQLSSLHPELF-YGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRL 193
Query: 130 KTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQF--------- 180
+++ F L L L L +N ++ ++ + F LS L L+L N ++
Sbjct: 194 RSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWG 253
Query: 181 ---PMDLYVGRFKLAELMFLDVSYN-RIPSMPMHHINLVPGK------QLRGIYLHGNPF 230
+DL K +L + N +I M + +N + K L + L GN +
Sbjct: 254 TLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGNLW 313
Query: 231 VCD---CSLYSLLVFWYRRHFSSVMDFKNDYT 259
C C+L S L + R S++ D+T
Sbjct: 314 ECSARICALASWLGSFQGRWEHSILCHSPDHT 345
Score = 56.6 bits (135), Expect = 5e-08
Identities = 44/146 (30%), Positives = 74/146 (50%), Gaps = 26/146 (17%)
Query: 56 NKNLSKVPGNLF---RLIKRLDLSYNRI---------GLLD--------SEWIPVSFA-- 93
+ +L +P LF R ++ LDLS NR+ GL+ ++ ++FA
Sbjct: 166 SNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHF 225
Query: 94 ----KLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLY 149
L+TL L+ N I++++ G T L+ LDL+ N++K + VF+ + L++LL+
Sbjct: 226 LRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMD 285
Query: 150 NNHISYLDPSAFGGLSQLQKLYLSGN 175
NN ++ LD L L + LSGN
Sbjct: 286 NNKLNSLDSKILNSLRSLTTVGLSGN 311
>gi|40217823 SLIT and NTRK-like family, member 5 [Homo sapiens]
Length = 958
Score = 83.6 bits (205), Expect = 4e-16
Identities = 71/212 (33%), Positives = 108/212 (50%), Gaps = 24/212 (11%)
Query: 40 VCPTACICATD----IVSCTNK---NLSKVPGNLFRLIKRLDLSYNRIG-LLDSEWIPVS 91
+C AC C VSC N+ +LS++ F + L LS N + L +E+ V+
Sbjct: 47 ICDNACPCEEKDGILTVSCENRGIISLSEISPPRFPIYHLL-LSGNLLNRLYPNEF--VN 103
Query: 92 FAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNN 151
+ + L L N I I TG+F L+ L L++NKL+ +++ F L+ LE L + N
Sbjct: 104 YTGASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYN 163
Query: 152 HISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMP--- 208
+IS ++P+AFG L LQ L L+ N L+ P +L F+ L LD+ NR+ +P
Sbjct: 164 YISVIEPNAFGKLHLLQVLILNDNLLSSLPNNL----FRFVPLTHLDLRGNRLKLLPYVG 219
Query: 209 -MHHINLVPGKQLRGIYLHGNPFVCDCSLYSL 239
+ H++ V Q L NP+ C C L SL
Sbjct: 220 LLQHMDKVVELQ-----LEENPWNCSCELISL 246
Score = 68.6 bits (166), Expect = 1e-11
Identities = 58/211 (27%), Positives = 96/211 (45%), Gaps = 22/211 (10%)
Query: 41 CPTACICATDI------VSCTNKNLSKV------PGNLFRLIKRLDLSYNRIGLLDSEWI 88
CPTAC C I V+C + + + P N K++ L+ N I ++
Sbjct: 374 CPTACSCNLQISDLGLNVNCQERKIESIAELQPKPYN----PKKMYLTENYIAVVRRTDF 429
Query: 89 PVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLL 148
+ L+ L L +N I+ I +F NL+ L L+ N+++ + +F L+ L+ L L
Sbjct: 430 -LEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPELFYGLQSLQYLFL 488
Query: 149 YNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMP 208
N I + F + LQ L+L+ N L P ++ G L+ L++ N S+P
Sbjct: 489 QYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSG----LTLLRLNLRSNHFTSLP 544
Query: 209 MHHINLVPGKQLRGIYLHGNPFVCDCSLYSL 239
+ + L K L I LH NP+ C C + +
Sbjct: 545 VSGV-LDQLKSLIQIDLHDNPWDCTCDIVGM 574
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 83.2 bits (204), Expect = 5e-16
Identities = 56/196 (28%), Positives = 90/196 (45%), Gaps = 30/196 (15%)
Query: 41 CPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLIL 100
CP+ C C+ +IV C K L ++P NL P ++ L
Sbjct: 280 CPSPCTCSNNIVDCRGKGLMEIPANL----------------------PEGIVEIR---L 314
Query: 101 RHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSA 160
N+I +I G+F+ LK +D+S N++ + FQ LK L L+LY N I+ +
Sbjct: 315 EQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGL 374
Query: 161 FGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQL 220
F GL LQ L L+ N + ++ + L L L + N++ ++ P + +
Sbjct: 375 FDGLVSLQLLLLNANKINCLRVNTFQ---DLQNLNLLSLYDNKLQTISKG--LFAPLQSI 429
Query: 221 RGIYLHGNPFVCDCSL 236
+ ++L NPFVCDC L
Sbjct: 430 QTLHLAQNPFVCDCHL 445
Score = 82.4 bits (202), Expect = 9e-16
Identities = 62/208 (29%), Positives = 95/208 (45%), Gaps = 32/208 (15%)
Query: 40 VCPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLI 99
VCP C C IV C+N+ L ++P +L + L L+ N + +L++
Sbjct: 504 VCPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEA-------------- 549
Query: 100 LRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPS 159
TG F PNL+ ++LS+NK+K V+ F ++ L+L N + +
Sbjct: 550 ----------TGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGR 599
Query: 160 AFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSM-PMHHINLVPGK 218
F GLS L+ L L N + D + G L+ + L + NRI ++ P LV
Sbjct: 600 VFRGLSGLKTLMLRSNLIGCVSNDTFAG---LSSVRLLSLYDNRITTITPGAFTTLV--- 653
Query: 219 QLRGIYLHGNPFVCDCSLYSLLVFWYRR 246
L I L NPF C+C L + L W R+
Sbjct: 654 SLSTINLLSNPFNCNCHL-AWLGKWLRK 680
Score = 80.9 bits (198), Expect = 3e-15
Identities = 74/256 (28%), Positives = 105/256 (41%), Gaps = 52/256 (20%)
Query: 12 LGAVVRPGCRELLCLLMITVTVGPGASGVCPTACICATDIVSCTNKNLSKVPGNLFRLIK 71
+GA VR R L L + +V GP A CPT C C+ V C L VP + R +
Sbjct: 8 VGAAVR--ARLALALALASVLSGPPAVA-CPTKCTCSAASVDCHGLGLRAVPRGIPRNAE 64
Query: 72 RLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKT 131
RLDL NNIT I+ F+ NL+ L L N++
Sbjct: 65 RLDLD-------------------------RNNITRITKMDFAGLKNLRVLHLEDNQVSV 99
Query: 132 VKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLY------ 185
++ FQ+LK LE L L N + L F +L +L LS N + P +
Sbjct: 100 IERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDV 159
Query: 186 --------------VGRFK-LAELMFLDVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPF 230
G F+ L +L L ++ N I + + N +P ++R + LH N
Sbjct: 160 KNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMP--KIRTLRLHSNHL 217
Query: 231 VCDCSLYSLLVFWYRR 246
CDC L + L W R+
Sbjct: 218 YCDCHL-AWLSDWLRQ 232
Score = 66.6 bits (161), Expect = 5e-11
Identities = 44/136 (32%), Positives = 69/136 (50%), Gaps = 4/136 (2%)
Query: 41 CPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLI- 99
CP C C +V C+NK L +P + + + L L N + + E +S + TLI
Sbjct: 725 CPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRE---LSALRHLTLID 781
Query: 100 LRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPS 159
L +N+I+ ++ +FS +L L LS N+L+ + F L+ L VL L+ N IS +
Sbjct: 782 LSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEG 841
Query: 160 AFGGLSQLQKLYLSGN 175
+F L+ L L L N
Sbjct: 842 SFNDLTSLSHLALGTN 857
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 82.8 bits (203), Expect = 7e-16
Identities = 67/229 (29%), Positives = 93/229 (40%), Gaps = 30/229 (13%)
Query: 18 PGCRELLCLLMITVTVGPGASGVCPTACI--CATD---IVSCTNKNLSKVPGNLFRLIKR 72
PG LLC L + + G SG P C C+ D V C+ K L+ VP L +
Sbjct: 2 PGPLGLLCFLALGLLGSAGPSGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQA 61
Query: 73 LDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTV 132
LD+S N NIT + +F P L+ L L+ N L +
Sbjct: 62 LDISMN-------------------------NITQLPEDAFKNFPFLEELQLAGNDLSFI 96
Query: 133 KNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLA 192
LK L+VL L NN + + A GLS LQ L L N +T P D + G +L
Sbjct: 97 HPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLR 156
Query: 193 ELMFLDVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLLV 241
L D S +P P+ ++ + L + P +L SL+V
Sbjct: 157 HLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVV 205
Score = 63.2 bits (152), Expect = 6e-10
Identities = 57/194 (29%), Positives = 87/194 (44%), Gaps = 12/194 (6%)
Query: 51 IVSCTNKNLSKVPGNLFR---LIKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITS 107
+++ N L VP R ++ L L N I + + +L L L N++T
Sbjct: 109 VLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFE-GLVQLRHLWLDDNSLTE 167
Query: 108 ISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQL 167
+ S P L+ L L+ NK+ ++ + F L L VL L+NN I L F GL L
Sbjct: 168 VPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNL 227
Query: 168 QKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQLRGIYLHG 227
+ L L+ N L +FP + L L L N I +P + P LR I+L+
Sbjct: 228 ETLDLNYNNLGEFPQAIKA----LPSLKELGFHSNSISVIPDGAFDGNP--LLRTIHLYD 281
Query: 228 NP--FVCDCSLYSL 239
NP FV + + ++L
Sbjct: 282 NPLSFVGNSAFHNL 295
Score = 50.1 bits (118), Expect = 5e-06
Identities = 39/128 (30%), Positives = 61/128 (47%), Gaps = 9/128 (7%)
Query: 52 VSCTNKNLSKVPGNLF---RLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSI 108
++ T +S +P NL ++++ LDLSYN I L S L + L+ N I I
Sbjct: 324 LTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPSF---NGCHALEEISLQRNQIYQI 380
Query: 109 STGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQ 168
G+F +L+ LDLS N + + + F L + L + N ++ GL+QL+
Sbjct: 381 KEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLK 440
Query: 169 KLYLSGNF 176
L GNF
Sbjct: 441 ---LVGNF 445
Score = 48.5 bits (114), Expect = 1e-05
Identities = 34/113 (30%), Positives = 52/113 (46%), Gaps = 4/113 (3%)
Query: 95 LNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHIS 154
L TL L +NN+ + P+LK L SN + + + F +L + LY+N +S
Sbjct: 227 LETLDLNYNNLGEFPQ-AIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLS 285
Query: 155 YLDPSAFGGLSQLQKLYLSG-NFLTQFPMDLYVGRFKLAELMFLDVSYNRIPS 206
++ SAF LS L L + G + + QFP G L L + IP+
Sbjct: 286 FVGNSAFHNLSDLHSLVIRGASMVQQFPN--LTGTVHLESLTLTGTKISSIPN 336
Score = 47.4 bits (111), Expect = 3e-05
Identities = 37/109 (33%), Positives = 51/109 (46%), Gaps = 10/109 (9%)
Query: 95 LNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHIS 154
L TL L +NNI + SF+ L+ + L N++ +K FQ L L +L L N I
Sbjct: 345 LRTLDLSYNNIRDLP--SFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIH 402
Query: 155 YLDPSAFGGLSQLQKLYLSGNFLTQFPMD--------LYVGRFKLAELM 195
+ AF L + L +S N LT FP + VG FKL E +
Sbjct: 403 EIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLKLVGNFKLKEAL 451
Score = 45.1 bits (105), Expect = 2e-04
Identities = 35/119 (29%), Positives = 52/119 (43%), Gaps = 5/119 (4%)
Query: 95 LNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHIS 154
L +L L I+SI L+ LDLS N ++ + + F LE + L N I
Sbjct: 321 LESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPS--FNGCHALEEISLQRNQIY 378
Query: 155 YLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMHHIN 213
+ F GL L+ L LS N + + + L + LDVS+N + S P +N
Sbjct: 379 QIKEGTFQGLISLRILDLSRNLIHEIHSRAFA---TLGPITNLDVSFNELTSFPTEGLN 434
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 82.4 bits (202), Expect = 9e-16
Identities = 92/343 (26%), Positives = 150/343 (43%), Gaps = 78/343 (22%)
Query: 16 VRPGCRELLCLLMITVTVGP--------GASG-----VCPTACICATD------IVSCTN 56
+R G L LL+ V +GP G G CP AC+C+ D V C++
Sbjct: 3 LRKGGLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSS 62
Query: 57 KNLSKVP-------------GNLFRLIKR-----------LDLSYNRIGLLDSEWIPVSF 92
+NL+++P GN + L+L ++G L+ + + +
Sbjct: 63 RNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQAL-LGL 121
Query: 93 AKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNH 152
L L L N + S++ G+F+ TP L L LS+N+L +++ +F+ L L L L N
Sbjct: 122 ENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNS 181
Query: 153 ISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMHHI 212
++ L +AF GL L++L L+GN L L+ G LAEL LD+S N + ++ +
Sbjct: 182 LAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSG---LAELRELDLSRNALRAIKANVF 238
Query: 213 NLVPGKQLRGIYLHGNPFVCDCSLYSLLVFWYRRHFSSVMDFKNDYTCRLWSDSRHSRQV 272
+P +L+ +YL N L+ F + + W D H+R
Sbjct: 239 VQLP--RLQKLYLDRN----------LIAAVAPGAFLGLKALR-------WLDLSHNRVA 279
Query: 273 LLLQDSF------------MNCSDSIINGSFRALGFIHEAQVG 303
LL+D+F N S+ +F+ L F+ E Q+G
Sbjct: 280 GLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLG 322
Score = 63.5 bits (153), Expect = 4e-10
Identities = 64/238 (26%), Positives = 100/238 (42%), Gaps = 68/238 (28%)
Query: 70 IKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKL 129
++ L L +NRI L +E +L L L HN + + G+F N+ ++LS N L
Sbjct: 316 LEELQLGHNRIRQL-AERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL 374
Query: 130 KTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLY------------------ 171
+ + VF+ L L L L + + + P F GLS L++L+
Sbjct: 375 RNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLA 434
Query: 172 ------LSGNFLTQFPMDLYVG----------RFKLAEL-----------MFLDVSYNRI 204
L+ N LT P L+ G R +LAEL +LDVS+NR+
Sbjct: 435 ELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRL 494
Query: 205 PSMP---------MHHINL-----------VPGKQLRGIYLHGNPFVCDCSLYSLLVF 242
++P + +++L PG L ++L GNP+ C C L +L F
Sbjct: 495 EALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPG--LERLWLEGNPWDCGCPLKALRDF 550
Score = 62.0 bits (149), Expect = 1e-09
Identities = 42/127 (33%), Positives = 64/127 (50%), Gaps = 1/127 (0%)
Query: 68 RLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSN 127
+ ++ LDLS+NR+ L + P L L L HN I S+ +F L+ L L N
Sbjct: 266 KALRWLDLSHNRVAGLLEDTFP-GLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHN 324
Query: 128 KLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVG 187
+++ + F+ L LEVL L +N + + AF GL+ + + LSGN L P ++ G
Sbjct: 325 RIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRG 384
Query: 188 RFKLAEL 194
KL L
Sbjct: 385 LGKLHSL 391
Score = 53.9 bits (128), Expect = 3e-07
Identities = 41/135 (30%), Positives = 67/135 (49%), Gaps = 4/135 (2%)
Query: 70 IKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKL 129
++ LDLS N + + + + V +L L L N I +++ G+F L+ LDLS N++
Sbjct: 220 LRELDLSRNALRAIKAN-VFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRV 278
Query: 130 KTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRF 189
+ F L L VL L +N I+ L P F L L++L L N + Q + G
Sbjct: 279 AGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEG-- 336
Query: 190 KLAELMFLDVSYNRI 204
L +L L + +N++
Sbjct: 337 -LGQLEVLTLDHNQL 350
>gi|52353306 leucine rich repeat containing 55 [Homo sapiens]
Length = 341
Score = 82.4 bits (202), Expect = 9e-16
Identities = 68/276 (24%), Positives = 116/276 (42%), Gaps = 32/276 (11%)
Query: 23 LLCLLMITVTVGPGASGVCPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGL 82
L+ LL+ + A CP C C +V C+++ L VP +L + L L++NRI
Sbjct: 63 LISLLLAAGLMHSDAGTSCPVLCTCRNQVVDCSSQRLFSVPPDLPMDTRNLSLAHNRITA 122
Query: 83 LDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELK- 141
+ ++ + +L L L +N++ + G F L LDLS N V +FQE
Sbjct: 123 VPPGYL-TCYMELQVLDLHNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAHG 181
Query: 142 VLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSY 201
++ + L +N + + P AF GL QL+ LD+SY
Sbjct: 182 LVHIDLSHNPWLRRVHPQAFQGLMQLRD---------------------------LDLSY 214
Query: 202 NRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLLVFWYRRHFSSVMDFKNDYTCR 261
+ + + + +PG L + + GNP+VC C++ LL W R CR
Sbjct: 215 GGLAFLSLEALEGLPG--LVTLQIGGNPWVCGCTMEPLLK-WLRNRIQRCTADSQLAECR 271
Query: 262 LWSDSRHSRQVLLLQDSFMNCSDSIINGSFRALGFI 297
+ + L ++SF C ++ + + F+
Sbjct: 272 GPPEVEGAPLFSLTEESFKACHLTLTLDDYLFIAFV 307
>gi|229089140 leucine rich repeat containing 24 [Homo sapiens]
Length = 513
Score = 82.0 bits (201), Expect = 1e-15
Identities = 65/214 (30%), Positives = 103/214 (48%), Gaps = 6/214 (2%)
Query: 26 LLMITVTVGPGASGVCPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLDS 85
LL + + + P + CP AC C + V C L VP + + L L N I L+
Sbjct: 8 LLPLLLLLLPLRAAGCPAACRCYSATVECGALRLRVVPLGIPPGTQTLFLQDNNIARLEP 67
Query: 86 EWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEV 145
+ A L L L +N++ ++ G+F P L L L+SN+L+ +++ F L L V
Sbjct: 68 GAL-APLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRV 126
Query: 146 LLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIP 205
L L N ++ L F L +LQ+L+L N + G L+ L LD+S N++
Sbjct: 127 LYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAG---LSSLALLDLSRNQLG 183
Query: 206 SMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSL 239
++ L P L+ + L NP+ CDC+L+ L
Sbjct: 184 TISRE--ALQPLASLQVLRLTENPWRCDCALHWL 215
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 81.6 bits (200), Expect = 2e-15
Identities = 84/314 (26%), Positives = 139/314 (44%), Gaps = 65/314 (20%)
Query: 32 TVGPGASGVCPTACICATD------IVSCTNKNLSKVP-------------GNLFRLIKR 72
T G CP AC+C+ D V C+++NL+++P GN +
Sbjct: 70 TPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPP 129
Query: 73 -----------LDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKC 121
L+L ++G L+ + + + L L L N + S++ G+F+ TP L
Sbjct: 130 AAFQNLSSLGFLNLQGGQLGSLEPQAL-LGLENLCHLHLERNQLRSLALGTFAHTPALAS 188
Query: 122 LDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFP 181
L LS+N+L +++ +F+ L L L L N ++ L +AF GL L++L L+GN L
Sbjct: 189 LGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQ 248
Query: 182 MDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLLV 241
L+ G LAEL LD+S N + ++ + +P +L+ +YL N L+
Sbjct: 249 PALFSG---LAELRELDLSRNALRAIKANVFVQLP--RLQKLYLDRN----------LIA 293
Query: 242 FWYRRHFSSVMDFKNDYTCRLWSDSRHSRQVLLLQDSF------------MNCSDSIING 289
F + + W D H+R LL+D+F N S+
Sbjct: 294 AVAPGAFLGLKALR-------WLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPR 346
Query: 290 SFRALGFIHEAQVG 303
+F+ L F+ E Q+G
Sbjct: 347 TFKDLHFLEELQLG 360
Score = 63.5 bits (153), Expect = 4e-10
Identities = 64/238 (26%), Positives = 100/238 (42%), Gaps = 68/238 (28%)
Query: 70 IKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKL 129
++ L L +NRI L +E +L L L HN + + G+F N+ ++LS N L
Sbjct: 354 LEELQLGHNRIRQL-AERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL 412
Query: 130 KTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLY------------------ 171
+ + VF+ L L L L + + + P F GLS L++L+
Sbjct: 413 RNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLA 472
Query: 172 ------LSGNFLTQFPMDLYVG----------RFKLAEL-----------MFLDVSYNRI 204
L+ N LT P L+ G R +LAEL +LDVS+NR+
Sbjct: 473 ELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRL 532
Query: 205 PSMP---------MHHINL-----------VPGKQLRGIYLHGNPFVCDCSLYSLLVF 242
++P + +++L PG L ++L GNP+ C C L +L F
Sbjct: 533 EALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPG--LERLWLEGNPWDCGCPLKALRDF 588
Score = 62.0 bits (149), Expect = 1e-09
Identities = 42/127 (33%), Positives = 64/127 (50%), Gaps = 1/127 (0%)
Query: 68 RLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSN 127
+ ++ LDLS+NR+ L + P L L L HN I S+ +F L+ L L N
Sbjct: 304 KALRWLDLSHNRVAGLLEDTFP-GLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHN 362
Query: 128 KLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVG 187
+++ + F+ L LEVL L +N + + AF GL+ + + LSGN L P ++ G
Sbjct: 363 RIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRG 422
Query: 188 RFKLAEL 194
KL L
Sbjct: 423 LGKLHSL 429
Score = 53.9 bits (128), Expect = 3e-07
Identities = 41/135 (30%), Positives = 67/135 (49%), Gaps = 4/135 (2%)
Query: 70 IKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKL 129
++ LDLS N + + + + V +L L L N I +++ G+F L+ LDLS N++
Sbjct: 258 LRELDLSRNALRAIKAN-VFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRV 316
Query: 130 KTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRF 189
+ F L L VL L +N I+ L P F L L++L L N + Q + G
Sbjct: 317 AGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEG-- 374
Query: 190 KLAELMFLDVSYNRI 204
L +L L + +N++
Sbjct: 375 -LGQLEVLTLDHNQL 388
>gi|41582239 immunoglobulin superfamily containing leucine-rich
repeat [Homo sapiens]
Length = 428
Score = 79.3 bits (194), Expect = 8e-15
Identities = 92/368 (25%), Positives = 143/368 (38%), Gaps = 60/368 (16%)
Query: 36 GASGVCPTACICAT----DIVSCTNKNLSKVPGNLFRLIKRLDLSYNRI-GLLDSEWIPV 90
G + CP C C I C ++L VP + L LS NR+ GL + + V
Sbjct: 14 GLAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREV 73
Query: 91 SFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYN 150
L +L L HN I +++ G+ ++ +LK LDLS N + + L L++L + +
Sbjct: 74 PL--LQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDS 131
Query: 151 NHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMH 210
N ++++ AF L L+ L L+ N L LAE F
Sbjct: 132 NELTFIPRDAFRSLRALRSLQLNHNRL-----------HTLAEGTF-------------- 166
Query: 211 HINLVPGKQLRGIYLHGNPFVCDCSLYSLLVFWYRRHFSSVMDFKNDYTCRLWSDSRHSR 270
P L + ++ NPF C C + L W S+ + +++ C + +
Sbjct: 167 ----TPLTALSHLQINENPFDCTCGIVWLKT-WALTTAVSIPE-QDNIAC---TSPHVLK 217
Query: 271 QVLLLQDSFMNCSDSIINGSFRALGFIHEAQVGERLMVHCDSKTGNANTDFIW------- 323
L + + CS + S++ E + G L +HCD G W
Sbjct: 218 GTPLSRLPPLPCSAPSVQLSYQPSQDGAELRPGFVLALHCD-VDGQPAPQLHWHIQIPSG 276
Query: 324 --------VGPDNRLLEPD---KEMENFYVFHNGSLVIESPRFEDAGVYSCIAMNKQRLL 372
VG D R L F F NGSL+I + G YSC+A N+
Sbjct: 277 IVEITSPNVGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSA 336
Query: 373 NETVDVTI 380
+VDV +
Sbjct: 337 ESSVDVAL 344
>gi|5031809 immunoglobulin superfamily containing leucine-rich
repeat [Homo sapiens]
Length = 428
Score = 79.3 bits (194), Expect = 8e-15
Identities = 92/368 (25%), Positives = 143/368 (38%), Gaps = 60/368 (16%)
Query: 36 GASGVCPTACICAT----DIVSCTNKNLSKVPGNLFRLIKRLDLSYNRI-GLLDSEWIPV 90
G + CP C C I C ++L VP + L LS NR+ GL + + V
Sbjct: 14 GLAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREV 73
Query: 91 SFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYN 150
L +L L HN I +++ G+ ++ +LK LDLS N + + L L++L + +
Sbjct: 74 PL--LQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDS 131
Query: 151 NHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMH 210
N ++++ AF L L+ L L+ N L LAE F
Sbjct: 132 NELTFIPRDAFRSLRALRSLQLNHNRL-----------HTLAEGTF-------------- 166
Query: 211 HINLVPGKQLRGIYLHGNPFVCDCSLYSLLVFWYRRHFSSVMDFKNDYTCRLWSDSRHSR 270
P L + ++ NPF C C + L W S+ + +++ C + +
Sbjct: 167 ----TPLTALSHLQINENPFDCTCGIVWLKT-WALTTAVSIPE-QDNIAC---TSPHVLK 217
Query: 271 QVLLLQDSFMNCSDSIINGSFRALGFIHEAQVGERLMVHCDSKTGNANTDFIW------- 323
L + + CS + S++ E + G L +HCD G W
Sbjct: 218 GTPLSRLPPLPCSAPSVQLSYQPSQDGAELRPGFVLALHCD-VDGQPAPQLHWHIQIPSG 276
Query: 324 --------VGPDNRLLEPD---KEMENFYVFHNGSLVIESPRFEDAGVYSCIAMNKQRLL 372
VG D R L F F NGSL+I + G YSC+A N+
Sbjct: 277 IVEITSPNVGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSA 336
Query: 373 NETVDVTI 380
+VDV +
Sbjct: 337 ESSVDVAL 344
>gi|149773484 leucine rich repeat and fibronectin type III domain
containing 1 [Homo sapiens]
Length = 771
Score = 78.2 bits (191), Expect = 2e-14
Identities = 95/389 (24%), Positives = 153/389 (39%), Gaps = 58/389 (14%)
Query: 28 MITVTVGPGASGVCPTACICA----TDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLL 83
++ + G CP CIC T + C L VP + R + L L+ N I +
Sbjct: 21 LLLLWAGASRGQPCPGRCICQNVAPTLTMLCAKTGLLFVPPAIDRRVVELRLTDNFIAAV 80
Query: 84 DSEWIPVSFAKLNTLI---LRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQEL 140
FA + +L+ L N I ++ G+F+ L+ L L SN+L V+ + L
Sbjct: 81 RRR----DFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQLRGL 136
Query: 141 KVLEVLLLYNNHISYLDPSAFGG-LSQLQKLYLSGNFLTQFPMD---------------- 183
L L+L NN I ++ +AF LS ++ L LS N L P +
Sbjct: 137 GNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHN 196
Query: 184 ----LYVGRF-KLAELMFLDVSYNRIPSMPMHHINL-------VPGKQLRGIYLHGNPFV 231
+ G F +L +L+ LD++ NR+ +P + L P L + GNP
Sbjct: 197 LIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFLRSQGTGPKPPTPLT-VSFGGNPLH 255
Query: 232 CDCSLYSLLVFWYRRHFSSVMDFKNDYTCRLWSDSRHSRQVLLLQDSFMNCSDSIINGSF 291
C+C L W RR + ++D + R + + C +I
Sbjct: 256 CNCEL-----LWLRR-----LTREDDLETCATPEHLTDRYFWSIPEEEFLCEPPLITRQA 305
Query: 292 RALGFIHEAQVGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIE 351
+ E G+ + + C + G+ WV PD RLL V +G+L +
Sbjct: 306 GGRALVVE---GQAVSLRCRA-VGDPEPVVHWVAPDGRLLGNSSRTR---VRGDGTLDVT 358
Query: 352 SPRFEDAGVYSCIAMNKQRLLNETVDVTI 380
D+G ++CIA N V+V +
Sbjct: 359 ITTLRDSGTFTCIASNAAGEATAPVEVCV 387
>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
sapiens]
Length = 593
Score = 77.8 bits (190), Expect = 2e-14
Identities = 57/197 (28%), Positives = 90/197 (45%), Gaps = 3/197 (1%)
Query: 27 LMITVTVGPGASGVCPTACICATD--IVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLD 84
L+ + + G+ G CP C C + V C ++ L VPG L + LDLS NR+ L
Sbjct: 17 LLFLLLLPGGSGGSCPAVCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQ 76
Query: 85 SEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLE 144
+ + L L L +N ++++ G+F +L L L N+L+ + VF L L
Sbjct: 77 QGMLS-RLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALT 135
Query: 145 VLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRI 204
+L L N I AFG L LQKL + N L + G KL+ L + + +
Sbjct: 136 LLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTV 195
Query: 205 PSMPMHHINLVPGKQLR 221
P + + + + +LR
Sbjct: 196 PGLALARLPALVALRLR 212
Score = 52.0 bits (123), Expect = 1e-06
Identities = 67/258 (25%), Positives = 95/258 (36%), Gaps = 30/258 (11%)
Query: 118 NLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFL 177
NL L ++ L +V L L VL L N IS + L +LQ+L LSG L
Sbjct: 253 NLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGACL 312
Query: 178 TQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLY 237
T + G L LDV+ N + ++ +L + L GNP CDC L
Sbjct: 313 TSIAAHAFHG---LTAFHLLDVADNALQTL--EETAFPSPDKLVTLRLSGNPLTCDCRLL 367
Query: 238 SLLVFWYRRHFSSVMD--------FKNDYTCRLWSDSRHSRQVLLLQDSFMNCSDSIING 289
LL RRH M + + +SD +L C ++I
Sbjct: 368 WLLRL--RRHLDFGMSPPACAGPHHVQGKSLKEFSD--------ILPPGHFTCKPALIRK 417
Query: 290 SFRALGFIHEAQVGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLV 349
S A+ G + C S G+ W+ P L + V +G+L
Sbjct: 418 SGPRWVI---AEEGGHAVFSC-SGDGDPAPTVSWMRPHGAWLGRAGRVR---VLEDGTLE 470
Query: 350 IESPRFEDAGVYSCIAMN 367
I S + D G Y C+ N
Sbjct: 471 IRSVQLRDRGAYVCVVSN 488
Score = 34.7 bits (78), Expect = 0.22
Identities = 31/106 (29%), Positives = 50/106 (47%), Gaps = 4/106 (3%)
Query: 52 VSCTNKNLSKVPGN-LFRL--IKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSI 108
++ T NLS VP L+ L ++ LDLS N I + + + +L L L +TSI
Sbjct: 257 LAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLS-PLVRLQELRLSGACLTSI 315
Query: 109 STGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHIS 154
+ +F LD++ N L+T++ F L L L N ++
Sbjct: 316 AAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLT 361
Score = 34.7 bits (78), Expect = 0.22
Identities = 27/84 (32%), Positives = 39/84 (46%)
Query: 95 LNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHIS 154
L L L N I++I S L+ L LS L ++ F L +L + +N +
Sbjct: 278 LRVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQ 337
Query: 155 YLDPSAFGGLSQLQKLYLSGNFLT 178
L+ +AF +L L LSGN LT
Sbjct: 338 TLEETAFPSPDKLVTLRLSGNPLT 361
>gi|40217825 slit and trk like 6 [Homo sapiens]
Length = 841
Score = 77.4 bits (189), Expect = 3e-14
Identities = 65/234 (27%), Positives = 108/234 (46%), Gaps = 34/234 (14%)
Query: 23 LLCLLMITVTVGPGASGVCPTACIC----ATDIVSCTNKNLSKV------PGNLFRLIKR 72
L C+ + + T + G C + C C T +++C K + V P F+L
Sbjct: 13 LACISLHSQTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQL--- 69
Query: 73 LDLSYNRIGLLDSEWIPVSFAKLNTLILRH---NNITSISTGSFSTTPNLKCLDLSSNKL 129
L N + +L + F+ L I H NNI I G+F+ LK L ++ N L
Sbjct: 70 -SLLNNGLTMLHTN----DFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSL 124
Query: 130 KTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRF 189
+ +K F L+ LE L NN I+ ++PSAF L++L+ L L+ N + P ++ F
Sbjct: 125 EILKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNI----F 180
Query: 190 KLAELMFLDVSYNRIPSMP----MHHINLVPGKQLRGIYLHGNPFVCDCSLYSL 239
+ L LD+ N++ ++P + HI ++ + L N + C+C L L
Sbjct: 181 RFVPLTHLDLRGNQLQTLPYVGFLEHIG-----RILDLQLEDNKWACNCDLLQL 229
Score = 57.0 bits (136), Expect = 4e-08
Identities = 38/111 (34%), Positives = 62/111 (55%), Gaps = 5/111 (4%)
Query: 118 NLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFL 177
N + L L+ N + ++ + E LE+L L NN I L+ +F L++LQKLYL+GN L
Sbjct: 364 NPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHL 423
Query: 178 TQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQLRGIYLHGN 228
T+ +++G L L +L + YN I + N +P +L+ +YL+ N
Sbjct: 424 TKLSKGMFLG---LHNLEYLYLEYNAIKEILPGTFNPMP--KLKVLYLNNN 469
Score = 54.7 bits (130), Expect = 2e-07
Identities = 38/113 (33%), Positives = 57/113 (50%), Gaps = 2/113 (1%)
Query: 70 IKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKL 129
++ L L NRI +L+ E ++ +L L L N++T +S G F NL+ L L N +
Sbjct: 389 LEMLHLGNNRIEVLE-EGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAI 447
Query: 130 KTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPM 182
K + F + L+VL L NN + L P F G+ L K+ L N T P+
Sbjct: 448 KEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGV-PLTKVNLKTNQFTHLPV 499
Score = 48.1 bits (113), Expect = 2e-05
Identities = 44/165 (26%), Positives = 68/165 (41%), Gaps = 27/165 (16%)
Query: 98 LILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLD 157
LIL N I S+ L+ L L +N+++ ++ F L L+ L L NH++ L
Sbjct: 368 LILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLS 427
Query: 158 PSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFK-LAELMFLDVSYNRIPSMPMHHINLVP 216
F GL L+ LYL N + ++ G F + +L L ++ N + +P H + VP
Sbjct: 428 KGMFLGLHNLEYLYLEYNAI----KEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVP 483
Query: 217 GKQ----------------------LRGIYLHGNPFVCDCSLYSL 239
+ L I L NP+ C C L L
Sbjct: 484 LTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGL 528
Score = 35.4 bits (80), Expect = 0.13
Identities = 32/111 (28%), Positives = 53/111 (47%), Gaps = 2/111 (1%)
Query: 65 NLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDL 124
NL RL ++L L+ N + L S+ + + L L L +N I I G+F+ P LK L L
Sbjct: 409 NLTRL-QKLYLNGNHLTKL-SKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYL 466
Query: 125 SSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGN 175
++N L+ + +F + + +V L N + L L ++ L N
Sbjct: 467 NNNLLQVLPPHIFSGVPLTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDN 517
>gi|40217820 slit and trk like 3 protein [Homo sapiens]
Length = 977
Score = 77.4 bits (189), Expect = 3e-14
Identities = 62/211 (29%), Positives = 99/211 (46%), Gaps = 26/211 (12%)
Query: 40 VCPTACICATDI------VSCTNKNLSKVPGNLFRLI--KRLDLSYNRIGLL--DSEWIP 89
+CPT C C I V+C + + + L R + K+L LS N I + W
Sbjct: 372 ICPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSDFW-- 429
Query: 90 VSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLY 149
+F+ L+ L L +N I+ + G+F PNLK L L+ N ++ + +F+ L+ L L
Sbjct: 430 -NFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFE 488
Query: 150 NNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMP- 208
N I + P+AF + L+ L+L+ N L P D + G L L++ N +P
Sbjct: 489 FNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAG----TSLARLNLRKNYFLYLPV 544
Query: 209 ---MHHINLVPGKQLRGIYLHGNPFVCDCSL 236
+ H+N + I L+ NP+ C C L
Sbjct: 545 AGVLEHLNAIV-----QIDLNENPWDCTCDL 570
Score = 69.3 bits (168), Expect = 8e-12
Identities = 54/173 (31%), Positives = 82/173 (47%), Gaps = 10/173 (5%)
Query: 91 SFAKLNTLI---LRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLL 147
SF LN + L +N + I TG+F+ LK L L NKL +N F L+ LE L
Sbjct: 96 SFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFRNDTFLGLESLEYLQ 155
Query: 148 LYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSM 207
N I ++ AF LS+L+ L L+ N + P +L FK L LD+ NR+ +
Sbjct: 156 ADYNVIKRIESGAFRNLSKLRVLILNDNLIPMLPTNL----FKAVSLTHLDLRGNRLKVL 211
Query: 208 PMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLLVFWYRRHFSSVMDFKNDYTC 260
+ G+ L + L NP+ C C + L + R +++++ D TC
Sbjct: 212 FYRGMLDHIGRSLMELQLEENPWNCTCEIVQLKSWLERIPYTALV---GDITC 261
Score = 38.1 bits (87), Expect = 0.020
Identities = 27/83 (32%), Positives = 38/83 (45%), Gaps = 3/83 (3%)
Query: 122 LDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFP 181
L L N ++ + F L + L NN + + AF GL L++LYL N L F
Sbjct: 82 LYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFR 141
Query: 182 MDLYVGRFKLAELMFLDVSYNRI 204
D ++G L L +L YN I
Sbjct: 142 NDTFLG---LESLEYLQADYNVI 161
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.136 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,776,155
Number of Sequences: 37866
Number of extensions: 878395
Number of successful extensions: 4323
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 223
Number of HSP's successfully gapped in prelim test: 186
Number of HSP's that attempted gapping in prelim test: 2368
Number of HSP's gapped (non-prelim): 1349
length of query: 522
length of database: 18,247,518
effective HSP length: 107
effective length of query: 415
effective length of database: 14,195,856
effective search space: 5891280240
effective search space used: 5891280240
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.