Guide to the Human Genome
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Search of human proteins with 219521831

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|219521831 adhesion molecule with Ig-like domain 2 [Homo
sapiens]
         (522 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|219521831 adhesion molecule with Ig-like domain 2 [Homo sapiens]  1053   0.0  
gi|32469517 adhesion molecule with Ig-like domain 2 [Homo sapiens]   1053   0.0  
gi|153791466 AMIGO protein [Homo sapiens]                             348   7e-96
gi|38454322 adhesion molecule with Ig-like domain 3 [Homo sapiens]    246   5e-65
gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]      112   6e-25
gi|139948432 adlican [Homo sapiens]                                   107   3e-23
gi|126517478 peroxidasin homolog-like [Homo sapiens]                  105   8e-23
gi|109150416 peroxidasin [Homo sapiens]                                97   3e-20
gi|4504379 leucine-rich repeat-containing G protein-coupled rece...    96   8e-20
gi|31542244 leucine rich repeat and fibronectin type III domain ...    95   2e-19
gi|54607118 leucine-rich repeats and immunoglobulin-like domains...    94   3e-19
gi|51317373 netrin-G1 ligand [Homo sapiens]                            92   9e-19
gi|188528675 slit homolog 1 [Homo sapiens]                             91   3e-18
gi|122937309 leucine rich repeat containing 4B [Homo sapiens]          89   7e-18
gi|4759146 slit homolog 2 [Homo sapiens]                               87   5e-17
gi|30425553 reticulon 4 receptor-like 1 [Homo sapiens]                 86   1e-16
gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo sa...    84   2e-16
gi|40217823 SLIT and NTRK-like family, member 5 [Homo sapiens]         84   4e-16
gi|11321571 slit homolog 3 [Homo sapiens]                              83   5e-16
gi|157694513 leucine-rich repeat-containing G protein-coupled re...    83   7e-16
gi|4826772 insulin-like growth factor binding protein, acid labi...    82   9e-16
gi|52353306 leucine rich repeat containing 55 [Homo sapiens]           82   9e-16
gi|229089140 leucine rich repeat containing 24 [Homo sapiens]          82   1e-15
gi|225579152 insulin-like growth factor binding protein, acid la...    82   2e-15
gi|41582239 immunoglobulin superfamily containing leucine-rich r...    79   8e-15
gi|5031809 immunoglobulin superfamily containing leucine-rich re...    79   8e-15
gi|149773484 leucine rich repeat and fibronectin type III domain...    78   2e-14
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo...    78   2e-14
gi|40217825 slit and trk like 6 [Homo sapiens]                         77   3e-14
gi|40217820 slit and trk like 3 protein [Homo sapiens]                 77   3e-14

>gi|219521831 adhesion molecule with Ig-like domain 2 [Homo sapiens]
          Length = 522

 Score = 1053 bits (2723), Expect = 0.0
 Identities = 522/522 (100%), Positives = 522/522 (100%)

Query: 1   MSLRVHTLPTLLGAVVRPGCRELLCLLMITVTVGPGASGVCPTACICATDIVSCTNKNLS 60
           MSLRVHTLPTLLGAVVRPGCRELLCLLMITVTVGPGASGVCPTACICATDIVSCTNKNLS
Sbjct: 1   MSLRVHTLPTLLGAVVRPGCRELLCLLMITVTVGPGASGVCPTACICATDIVSCTNKNLS 60

Query: 61  KVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLK 120
           KVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLK
Sbjct: 61  KVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLK 120

Query: 121 CLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQF 180
           CLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQF
Sbjct: 121 CLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQF 180

Query: 181 PMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLL 240
           PMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLL
Sbjct: 181 PMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLL 240

Query: 241 VFWYRRHFSSVMDFKNDYTCRLWSDSRHSRQVLLLQDSFMNCSDSIINGSFRALGFIHEA 300
           VFWYRRHFSSVMDFKNDYTCRLWSDSRHSRQVLLLQDSFMNCSDSIINGSFRALGFIHEA
Sbjct: 241 VFWYRRHFSSVMDFKNDYTCRLWSDSRHSRQVLLLQDSFMNCSDSIINGSFRALGFIHEA 300

Query: 301 QVGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGV 360
           QVGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGV
Sbjct: 301 QVGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGV 360

Query: 361 YSCIAMNKQRLLNETVDVTINVSNFTVSRSHAHEAFNTAFTTLAACVASIVLVLLYLYLT 420
           YSCIAMNKQRLLNETVDVTINVSNFTVSRSHAHEAFNTAFTTLAACVASIVLVLLYLYLT
Sbjct: 361 YSCIAMNKQRLLNETVDVTINVSNFTVSRSHAHEAFNTAFTTLAACVASIVLVLLYLYLT 420

Query: 421 PCPCKCKTKRQKNMLHQSNAHSSILSPGPASDASADERKAGAGKRVVFLEPLKDTAAGQN 480
           PCPCKCKTKRQKNMLHQSNAHSSILSPGPASDASADERKAGAGKRVVFLEPLKDTAAGQN
Sbjct: 421 PCPCKCKTKRQKNMLHQSNAHSSILSPGPASDASADERKAGAGKRVVFLEPLKDTAAGQN 480

Query: 481 GKVRLFPSEAVIAEGILKSTRGKSDSDSVNSVFSDTPFVAST 522
           GKVRLFPSEAVIAEGILKSTRGKSDSDSVNSVFSDTPFVAST
Sbjct: 481 GKVRLFPSEAVIAEGILKSTRGKSDSDSVNSVFSDTPFVAST 522


>gi|32469517 adhesion molecule with Ig-like domain 2 [Homo sapiens]
          Length = 522

 Score = 1053 bits (2723), Expect = 0.0
 Identities = 522/522 (100%), Positives = 522/522 (100%)

Query: 1   MSLRVHTLPTLLGAVVRPGCRELLCLLMITVTVGPGASGVCPTACICATDIVSCTNKNLS 60
           MSLRVHTLPTLLGAVVRPGCRELLCLLMITVTVGPGASGVCPTACICATDIVSCTNKNLS
Sbjct: 1   MSLRVHTLPTLLGAVVRPGCRELLCLLMITVTVGPGASGVCPTACICATDIVSCTNKNLS 60

Query: 61  KVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLK 120
           KVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLK
Sbjct: 61  KVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLK 120

Query: 121 CLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQF 180
           CLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQF
Sbjct: 121 CLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQF 180

Query: 181 PMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLL 240
           PMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLL
Sbjct: 181 PMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLL 240

Query: 241 VFWYRRHFSSVMDFKNDYTCRLWSDSRHSRQVLLLQDSFMNCSDSIINGSFRALGFIHEA 300
           VFWYRRHFSSVMDFKNDYTCRLWSDSRHSRQVLLLQDSFMNCSDSIINGSFRALGFIHEA
Sbjct: 241 VFWYRRHFSSVMDFKNDYTCRLWSDSRHSRQVLLLQDSFMNCSDSIINGSFRALGFIHEA 300

Query: 301 QVGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGV 360
           QVGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGV
Sbjct: 301 QVGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGV 360

Query: 361 YSCIAMNKQRLLNETVDVTINVSNFTVSRSHAHEAFNTAFTTLAACVASIVLVLLYLYLT 420
           YSCIAMNKQRLLNETVDVTINVSNFTVSRSHAHEAFNTAFTTLAACVASIVLVLLYLYLT
Sbjct: 361 YSCIAMNKQRLLNETVDVTINVSNFTVSRSHAHEAFNTAFTTLAACVASIVLVLLYLYLT 420

Query: 421 PCPCKCKTKRQKNMLHQSNAHSSILSPGPASDASADERKAGAGKRVVFLEPLKDTAAGQN 480
           PCPCKCKTKRQKNMLHQSNAHSSILSPGPASDASADERKAGAGKRVVFLEPLKDTAAGQN
Sbjct: 421 PCPCKCKTKRQKNMLHQSNAHSSILSPGPASDASADERKAGAGKRVVFLEPLKDTAAGQN 480

Query: 481 GKVRLFPSEAVIAEGILKSTRGKSDSDSVNSVFSDTPFVAST 522
           GKVRLFPSEAVIAEGILKSTRGKSDSDSVNSVFSDTPFVAST
Sbjct: 481 GKVRLFPSEAVIAEGILKSTRGKSDSDSVNSVFSDTPFVAST 522


>gi|153791466 AMIGO protein [Homo sapiens]
          Length = 493

 Score =  348 bits (893), Expect = 7e-96
 Identities = 204/498 (40%), Positives = 291/498 (58%), Gaps = 24/498 (4%)

Query: 24  LCLLMITVTVGPGASGVCPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLL 83
           L LL+  V     A   CP AC+CA++I+SC+ + L  VP +L      LDLS+N +  L
Sbjct: 17  LSLLLFEVARAGRAVVSCPAACLCASNILSCSKQQLPNVPHSLPSYTALLDLSHNNLSRL 76

Query: 84  DSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVL 143
            +EW P    +L++L+L HN++  IS+ +FS  PNL+ LDLSSN+L+T+   +F +L+VL
Sbjct: 77  RAEWTPTRLTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQVL 136

Query: 144 EVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNR 203
           EVLLLYNNHI  +D  AF  ++QLQKLYLS N +++FP++L     KL +L  LD+S N+
Sbjct: 137 EVLLLYNNHIMAVDRCAFDDMAQLQKLYLSQNQISRFPLELVKEGAKLPKLTLLDLSSNK 196

Query: 204 IPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLLVFWYRRHFSSVMDFKNDYTCRLW 263
           + ++P+  +  +P     G+YLH NP  CDC LY L   W  R  SSVMDF+ D  C   
Sbjct: 197 LKNLPLPDLQKLPAWIKNGLYLHNNPLNCDCELYQLFSHWQYRQLSSVMDFQEDLYC--- 253

Query: 264 SDSRHSRQVLLLQDSFMNCSDSIINGSFRALGFIHEAQVGERLMVHCDSKTGNANTDFIW 323
            +S+    V  L  SF+NC      G ++   +  EA +G+ L++ CD+K        +W
Sbjct: 254 MNSKKLHNVFNL--SFLNC------GEYKERAW--EAHLGDTLIIKCDTKQQGMTK--VW 301

Query: 324 VGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGVYSCIAMNKQRLLNETVDVTINVS 383
           V P N  +  +       V  +GSL+ +  + ED GVY+C AM +    NET+ V + V 
Sbjct: 302 VTPSNERVLDEVTNGTVSVSKDGSLLFQQVQVEDGGVYTCYAMGE--TFNETLSVELKVH 359

Query: 384 NFTVSRSHAHEAFNTAFTTLAACVASIVLVLLYLYLTPCPCKCKTKRQKNMLHQSNAHSS 443
           NFT+   H H+  NTA+TTL  C+ S+VLVL+YLYLTPC C C+   + +     +  SS
Sbjct: 360 NFTL-HGH-HDTLNTAYTTLVGCILSVVLVLIYLYLTPCRCWCRGVEKPSSHQGDSLSSS 417

Query: 444 ILSPGPASDASA-DERKAGAGKRVVFLEPLKDTAAGQNGKVRLFPSEAV-IAEGILKSTR 501
           +LS  P  D  A  ++  G  +RV FLEP      GQNGK++  P   + + E   K  R
Sbjct: 418 MLSTTPNHDPMAGGDKDDGFDRRVAFLEP-AGPGQGQNGKLK--PGNTLPVPEATGKGQR 474

Query: 502 GKSDSDSVNSVFSDTPFV 519
             SD +SV+SVFSDTP V
Sbjct: 475 RMSDPESVSSVFSDTPIV 492


>gi|38454322 adhesion molecule with Ig-like domain 3 [Homo sapiens]
          Length = 504

 Score =  246 bits (627), Expect = 5e-65
 Identities = 180/511 (35%), Positives = 251/511 (49%), Gaps = 35/511 (6%)

Query: 23  LLCLLMITVTVG------PGASGVCPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLS 76
           LLC+L + +         P A   CP  CICA D++SCT   L  VP  L      LDLS
Sbjct: 10  LLCMLRVGLGTPDSEGFPPRALHNCPYKCICAADLLSCTGLGLQDVPAELPAATADLDLS 69

Query: 77  YNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAV 136
           +N +  L   W+   F +L  L L HN + ++  G F     L+ LDLSSN L+ +    
Sbjct: 70  HNALQRLRPGWLAPLF-QLRALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRALGRHD 128

Query: 137 FQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMF 196
              L  LE LLL+NN + +LD  AF GL  L  LYL  N L  F  D ++       L+ 
Sbjct: 129 LDGLGALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASFSFD-HLHGLSATHLLT 187

Query: 197 LDVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLLVFWYRRHFSSVMDFKN 256
           LD+S NR+  + +  +  +P     G+YLH NP  CDC LY LL  W++R  S+V DF  
Sbjct: 188 LDLSSNRLGHISVPELAALPAFLKNGLYLHNNPLPCDCRLYHLLQRWHQRGLSAVRDFAR 247

Query: 257 DYTCRLWSDSRHSRQVLLLQDSFMNCSDSIINGSFRALGFIHEAQVGERLMVHCDSKTGN 316
           +Y C  +       +       F NCS +   G  R    ++ A VG  L ++C+  T  
Sbjct: 248 EYVCLAFKVPASRVRFFQHSRVFENCSSAPALGLERPEEHLY-ALVGRSLRLYCN--TSV 304

Query: 317 ANTDFIWVGPDNRLLE-PDKEMENFYVFHNGSLVIESPRFEDAGVYSCIAMNKQRLLNET 375
                 WV P   LL  P     +  V  +GSL I + + + AG++ C+A   +   N+T
Sbjct: 305 PAMRIAWVSPQQELLRAPGSRDGSIAVLADGSLAIGNVQEQHAGLFVCLATGPRLHHNQT 364

Query: 376 VDVTINVSNFTVSRSHAHEAFNTAFTTLAACVASIVLVLLYLYLTPCPC---KCKTKR-- 430
            +  ++V +F        EAFNT FTTL  C   +VLVLLYL+  PC C    C+ +R  
Sbjct: 365 HEYNVSV-HFPRPEP---EAFNTGFTTLLGCAVGLVLVLLYLFAPPCRCCRRACRCRRWP 420

Query: 431 -QKNMLHQSNAHSSILSPGPASDASADERKAGAGKRVVFLEPLKDTAAGQNGKVRLFPSE 489
              + L + +A SS+LS  P     A  RKA   K VVFLEP +    G NG+V+L    
Sbjct: 421 QTPSPLQELSAQSSVLSTTP---PDAPSRKASVHKHVVFLEPGR---RGLNGRVQL---- 470

Query: 490 AVIAEGILKSTRG---KSDSDSVNSVFSDTP 517
           AV  E  L +  G   K+ S+S +S+ S+ P
Sbjct: 471 AVAEEFDLYNPGGLQLKAGSESASSIGSEGP 501


>gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]
          Length = 2623

 Score =  112 bits (281), Expect = 6e-25
 Identities = 73/227 (32%), Positives = 126/227 (55%), Gaps = 16/227 (7%)

Query: 21  RELLCLLM----ITVTVGPGASGVCPTACICATDI-VSCTNKNLSKVPGNLFRLIKRLDL 75
           R + CLL+    I +   PG    CP  C C     V CT + L+ +P ++   ++R++L
Sbjct: 6   RGITCLLVSFAVICLVATPGGKA-CPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINL 64

Query: 76  SYNR-IGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKN 134
            YN  + L+++++  ++  KL  L+L  N I +I   +FS    L+ L +S NK++ ++ 
Sbjct: 65  GYNSLVRLMETDFSGLT--KLELLMLHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQK 122

Query: 135 AVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGR-----F 189
             F  L+ L  L + +N+I +++P  F GL+ L+ ++L GN LT+   D +V       F
Sbjct: 123 DTFYGLRSLTRLHMDHNNIEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIF 182

Query: 190 KLAELMFLDVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSL 236
           K++ + FL +S N + S+P   ++ +P   L  +YLHGNP+ CDC L
Sbjct: 183 KISFIKFLYLSDNFLTSLPQEMVSYMP--DLDSLYLHGNPWTCDCHL 227



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 33/115 (28%), Positives = 56/115 (48%), Gaps = 6/115 (5%)

Query: 255  KNDYTCRLWSDSRHSRQVLLLQDSFMNCSDSIINGSFRALGFIHEAQVGERLMVHCDSKT 314
            +  Y C   S +   R+V++L       S  I   S +      E   G++L+++C S T
Sbjct: 1912 RGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRT----EVNFGDKLLLNC-SAT 1966

Query: 315  GNANTDFIWVGPDNRLLEPDKEMENF-YVFHNGSLVIESPRFEDAGVYSCIAMNK 368
            G      +W  P   +++    + ++ +V+ NGSL I S   +D+GVY C+A NK
Sbjct: 1967 GEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNK 2021



 Score = 45.8 bits (107), Expect = 9e-05
 Identities = 25/81 (30%), Positives = 39/81 (48%), Gaps = 1/81 (1%)

Query: 300  AQVGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAG 359
            AQ+G+   ++C S  GN   + IW+ P+        +   + +  NGS +I     EDAG
Sbjct: 2349 AQLGKSTALNC-SVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAG 2407

Query: 360  VYSCIAMNKQRLLNETVDVTI 380
             Y C A NK   + + V + I
Sbjct: 2408 KYRCAARNKVGYIEKLVILEI 2428



 Score = 38.5 bits (88), Expect = 0.015
 Identities = 25/78 (32%), Positives = 37/78 (47%), Gaps = 3/78 (3%)

Query: 290 SFRALGFIHEAQVGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLV 349
           +++  G  H   +GE L + C S TG  +    WV P N +L      +   V +NG+L 
Sbjct: 575 AYQENGIHHTVFIGETLDLPCHS-TGIPDASISWVIPGNNVLYQSSRDKK--VLNNGTLR 631

Query: 350 IESPRFEDAGVYSCIAMN 367
           I     +D G Y C+A N
Sbjct: 632 ILQVTPKDQGYYRCVAAN 649



 Score = 37.0 bits (84), Expect = 0.044
 Identities = 21/68 (30%), Positives = 34/68 (50%), Gaps = 5/68 (7%)

Query: 301  QVGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFH-NGSLVIESPRFEDAG 359
            + G+  ++ C+  TG+      W+ P N ++    +    Y FH NGSL I   +  D+G
Sbjct: 2154 KAGDTAVLDCEV-TGDPKPKIFWLLPSNDMISFSIDR---YTFHANGSLTINKVKLLDSG 2209

Query: 360  VYSCIAMN 367
             Y C+A N
Sbjct: 2210 EYVCVARN 2217



 Score = 36.6 bits (83), Expect = 0.057
 Identities = 20/70 (28%), Positives = 35/70 (50%), Gaps = 4/70 (5%)

Query: 301  QVGERLMVHCDSKTGNANTDFIWVGPDNRLLEP---DKEMENFYVFHNGSLVIESPRFED 357
            + G    +HC +  G    +  W  PD+ LL     ++   +  +   G+LVI++P+  D
Sbjct: 2541 RTGAAFQLHCVA-LGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSD 2599

Query: 358  AGVYSCIAMN 367
            +G+Y C A N
Sbjct: 2600 SGIYKCTAKN 2609



 Score = 35.0 bits (79), Expect = 0.17
 Identities = 18/61 (29%), Positives = 29/61 (47%), Gaps = 1/61 (1%)

Query: 309  HCDSKT-GNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGVYSCIAMN 367
            H D +  G  + + +W+ PDN  L          V  NG+L I + R  D+  + C+A N
Sbjct: 2258 HFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARN 2317

Query: 368  K 368
            +
Sbjct: 2318 E 2318



 Score = 34.7 bits (78), Expect = 0.22
 Identities = 21/64 (32%), Positives = 31/64 (48%), Gaps = 2/64 (3%)

Query: 303  GERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMEN-FYVFHNGSLVIESPRFEDAGVY 361
            GE L + C +K G       WV  D   ++P +   +  ++F NG+L I +    D G Y
Sbjct: 1857 GESLKLPCTAK-GTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTY 1915

Query: 362  SCIA 365
             CIA
Sbjct: 1916 ECIA 1919



 Score = 34.3 bits (77), Expect = 0.28
 Identities = 24/78 (30%), Positives = 34/78 (43%), Gaps = 1/78 (1%)

Query: 303  GERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGVYS 362
            GE L +HC S  G    +  W  P   +++  +    + +  NG+LVI+     D G Y 
Sbjct: 2447 GESLSLHCVSD-GIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYI 2505

Query: 363  CIAMNKQRLLNETVDVTI 380
            C A N       TV V I
Sbjct: 2506 CKAQNSVGHTLITVPVMI 2523


>gi|139948432 adlican [Homo sapiens]
          Length = 2828

 Score =  107 bits (267), Expect = 3e-23
 Identities = 67/219 (30%), Positives = 111/219 (50%), Gaps = 9/219 (4%)

Query: 24  LCLLMITVTVGPGASGVCPTACIC-ATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGL 82
           L +++I +   P  +  CP  C C     V CT ++L+ VP  + + ++R++L +N I  
Sbjct: 10  LSVVLILLWGHPRVALACPHPCACYVPSEVHCTFRSLASVPAGIAKHVERINLGFNSIQA 69

Query: 83  LDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKV 142
           L SE       KL  L++  N I SI  G+     +L+    S NKL+ +     Q L  
Sbjct: 70  L-SETSFAGLTKLELLMIHGNEIPSIPDGALRDLSSLQVFKFSYNKLRVITGQTLQGLSN 128

Query: 143 LEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQ-----FPMDLYVGRFKLAELMFL 197
           L  L + +N I ++ P AF GL+ L+ L+L GN L Q     F    ++  F+L+ +  L
Sbjct: 129 LMRLHIDHNKIEFIHPQAFNGLTSLRLLHLEGNLLHQLHPSTFSTFTFLDYFRLSTIRHL 188

Query: 198 DVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSL 236
            ++ N + ++P   +  +P   L  +YL GNP+ CDC +
Sbjct: 189 YLAENMVRTLPASMLRNMP--LLENLYLQGNPWTCDCEM 225



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 31/137 (22%), Positives = 71/137 (51%), Gaps = 10/137 (7%)

Query: 247  HFSSV-MDFKNDYTCRLWSDSRHSRQVLLLQDSFMNCSDSIINGSFRALGFIHEAQVGER 305
            +F+ V M  + DYTC  +++++  +  + ++   +    +I N ++ A+    +   G+ 
Sbjct: 2310 YFNEVGMREEGDYTC--FAENQVGKDEMRVRVKVVTAPATIRNKTYLAV----QVPYGDV 2363

Query: 306  LMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGVYSCIA 365
            + V C++K G       W+ P N+++    E   + ++ +G+L+I+  +  D+G Y+C+ 
Sbjct: 2364 VTVACEAK-GEPMPKVTWLSPTNKVIPTSSE--KYQIYQDGTLLIQKAQRSDSGNYTCLV 2420

Query: 366  MNKQRLLNETVDVTINV 382
             N      +TV + +NV
Sbjct: 2421 RNSAGEDRKTVWIHVNV 2437



 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 18/58 (31%), Positives = 33/58 (56%)

Query: 323 WVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGVYSCIAMNKQRLLNETVDVTI 380
           W+ P+ R++       + Y+  NG+L I   +  D+G Y C+A+N+Q   + TV +T+
Sbjct: 611 WILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGITV 668



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 21/68 (30%), Positives = 33/68 (48%), Gaps = 1/68 (1%)

Query: 300  AQVGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAG 359
            A  G  + ++C S  G      +WV P+   L+  ++++ FY   +G L I      DAG
Sbjct: 2554 AMAGHTISLNC-SAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAG 2612

Query: 360  VYSCIAMN 367
             Y C+A N
Sbjct: 2613 AYRCVARN 2620



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 21/67 (31%), Positives = 33/67 (49%), Gaps = 2/67 (2%)

Query: 302  VGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFH-NGSLVIESPRFEDAGV 360
            +G+ + + C +K G       W+ PD R+ +    +E     H N +L I+   F D GV
Sbjct: 1964 LGDTIAMECLAK-GTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGV 2022

Query: 361  YSCIAMN 367
            Y C+A N
Sbjct: 2023 YKCVASN 2029



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 28/101 (27%), Positives = 49/101 (48%), Gaps = 4/101 (3%)

Query: 299  EAQVGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMEN-FYVFHNGSLVIESPRFED 357
            + + G  L + C S +G+     +W  P  R+++     ++   VF NG+LV++S   +D
Sbjct: 2157 DVRYGGTLKLDC-SASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKD 2215

Query: 358  AGVYSCIAMNK--QRLLNETVDVTINVSNFTVSRSHAHEAF 396
            AG Y C+A NK     +   VDV +  +       + H+ F
Sbjct: 2216 AGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVF 2256



 Score = 38.9 bits (89), Expect = 0.012
 Identities = 20/62 (32%), Positives = 31/62 (50%)

Query: 330  LLEPDKEMENFYVFHNGSLVIESPRFEDAGVYSCIAMNKQRLLNETVDVTINVSNFTVSR 389
            L+ P+  ++ F V  NG+LVI   + +D G Y C A N   L    V +++ V    +  
Sbjct: 1895 LMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILA 1954

Query: 390  SH 391
            SH
Sbjct: 1955 SH 1956



 Score = 38.9 bits (89), Expect = 0.012
 Identities = 23/79 (29%), Positives = 38/79 (48%), Gaps = 2/79 (2%)

Query: 303  GERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEME-NFYVFHNGSLVIESPRFEDAGVY 361
            G  + +HC +K     +   WV  D   + P + +  N +VF NG+L I +   +D+G Y
Sbjct: 2062 GLSIHIHCTAKAAPLPS-VRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRY 2120

Query: 362  SCIAMNKQRLLNETVDVTI 380
             C+A N       TV + +
Sbjct: 2121 ECVAANLVGSARRTVQLNV 2139



 Score = 35.4 bits (80), Expect = 0.13
 Identities = 35/149 (23%), Positives = 60/149 (40%), Gaps = 11/149 (7%)

Query: 298  HEAQVGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMEN-------FYVFHNGSLVI 350
            H+   G  L V C + TG  N +  W  PD  L+    + ++       + VF+NG+L  
Sbjct: 2253 HKVFYGGDLKVDCVA-TGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYF 2311

Query: 351  ESPRFEDAGVYSCIAMNKQRLLNETVDVTINVSNFTVSRSHAHEAFNTAF--TTLAACVA 408
                  + G Y+C A N+       V V +  +  T+ R+  + A    +      AC A
Sbjct: 2312 NEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATI-RNKTYLAVQVPYGDVVTVACEA 2370

Query: 409  SIVLVLLYLYLTPCPCKCKTKRQKNMLHQ 437
                +    +L+P      T  +K  ++Q
Sbjct: 2371 KGEPMPKVTWLSPTNKVIPTSSEKYQIYQ 2399



 Score = 35.4 bits (80), Expect = 0.13
 Identities = 29/113 (25%), Positives = 50/113 (44%), Gaps = 5/113 (4%)

Query: 257  DYTCRLWSDSRHSRQVLLLQDSFMNCSDSIINGSFRALGFIHE-AQVGERLMVHCDSKTG 315
            +YTC + + +   R+ + +    +N     ING+   +  + E A  G R ++ C ++ G
Sbjct: 2415 NYTCLVRNSAGEDRKTVWIH---VNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAE-G 2470

Query: 316  NANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGVYSCIAMNK 368
                  +W  P+  +L          V  NGSL I S R  D+    C+A N+
Sbjct: 2471 IPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNE 2523



 Score = 33.5 bits (75), Expect = 0.49
 Identities = 21/71 (29%), Positives = 34/71 (47%), Gaps = 3/71 (4%)

Query: 303 GERLMVHCDSKTGNANTDFIWVGPDNRLLEP--DKEMENFYVFHNGSLVIESPRFEDAGV 360
           G    + C+ K   + + F WV PD  +L+   D     F +  +G L I+S    D+G+
Sbjct: 494 GGPCQLSCNVKASESPSIF-WVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGL 552

Query: 361 YSCIAMNKQRL 371
           Y CIA  +  +
Sbjct: 553 YQCIAQVRDEM 563



 Score = 31.2 bits (69), Expect = 2.4
 Identities = 20/68 (29%), Positives = 30/68 (44%), Gaps = 4/68 (5%)

Query: 303  GERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEME---NFYVFHNGSLVIESPRFEDAG 359
            G  + ++C +  G    D  W  PD   L+   +     N ++   GSL I+     DAG
Sbjct: 2748 GNTVKLNCMAM-GIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAG 2806

Query: 360  VYSCIAMN 367
             Y C+A N
Sbjct: 2807 FYKCMAKN 2814



 Score = 29.6 bits (65), Expect = 7.0
 Identities = 17/61 (27%), Positives = 25/61 (40%), Gaps = 1/61 (1%)

Query: 303  GERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGVYS 362
            GE L + C +  G     F W  P+   LE  + +    +  NG+L +      D G Y 
Sbjct: 2652 GETLKLPC-TPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYV 2710

Query: 363  C 363
            C
Sbjct: 2711 C 2711


>gi|126517478 peroxidasin homolog-like [Homo sapiens]
          Length = 1463

 Score =  105 bits (263), Expect = 8e-23
 Identities = 100/349 (28%), Positives = 150/349 (42%), Gaps = 48/349 (13%)

Query: 23  LLCLLMITVTVGPGASGV-CPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIG 81
           L C   + +  G    G+ CP+ C+C    V C +  L  +P  + +    LDL +NRI 
Sbjct: 5   LFCWTTLFLLAGWCLPGLPCPSRCLCFKSTVRCMHLMLDHIP-QVPQQTTVLDLRFNRIR 63

Query: 82  LLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELK 141
            +           LNTL+L +N+I  IS  +F    NL  L L  N++  +    F+ L 
Sbjct: 64  EIPGSAFK-KLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKGLI 122

Query: 142 VLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSY 201
            LE L ++ N +  L P  FG L +L++L+L  N L++ P     G F            
Sbjct: 123 SLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIP----AGSFS----------- 167

Query: 202 NRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSL--LVFWYRRHFSSVMDFKNDYT 259
                      NL   K+LR   L  N  VCDC L  L  L+  + +H  +      +Y 
Sbjct: 168 -----------NLDSLKRLR---LDSNALVCDCDLMWLGELLQGFAQHGHTQAAATCEYP 213

Query: 260 CRLWSDSRHSRQVLLLQDSFMNCSDSIINGSFRALGFIHEAQVGERLMVHCDSKTGNANT 319
            RL     H R V  +     NC    I    + +    E   G  +   C ++ GN   
Sbjct: 214 RRL-----HGRAVASVTVEEFNCQSPRITFEPQDV----EVPSGNTVYFTCRAE-GNPKP 263

Query: 320 DFIWVGPDNRL-LEPDKEMENFYVFHNGSLVIESPRFEDAGVYSCIAMN 367
           + IW+  ++ L LE D  +    VF +G+L+I + R  D GVY C+A N
Sbjct: 264 EIIWIHNNHSLDLEDDTRLN---VFDDGTLMIRNTRESDQGVYQCMARN 309



 Score = 31.2 bits (69), Expect = 2.4
 Identities = 21/80 (26%), Positives = 35/80 (43%), Gaps = 5/80 (6%)

Query: 301 QVGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGV 360
           +VG+ + + C ++ G       W     ++ E  K    F+V   G+L I    F D G 
Sbjct: 523 EVGKNINISCHAQ-GEPQPIITWNKEGVQITESGK----FHVDDEGTLTIYDAGFPDQGR 577

Query: 361 YSCIAMNKQRLLNETVDVTI 380
           Y C+A N   L    + +T+
Sbjct: 578 YECVARNSFGLAVTNMFLTV 597


>gi|109150416 peroxidasin [Homo sapiens]
          Length = 1479

 Score = 97.4 bits (241), Expect = 3e-20
 Identities = 93/365 (25%), Positives = 150/365 (41%), Gaps = 66/365 (18%)

Query: 18  PGCRELLCLLMI-------TVTVGPGASGVCPTACICATDIVSCTNKNLSKVPGNLFRLI 70
           PG R LL L++         V   PGA   CP+ C+C    V C +  L           
Sbjct: 8   PGRRCLLALVLFCAWGTLAVVAQKPGAG--CPSRCLCFRTTVRCMHLLL----------- 54

Query: 71  KRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLK 130
                          E +P    + + L LR N I  I  G+F    NL  L L++N++K
Sbjct: 55  ---------------EAVPAVAPQTSILDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIK 99

Query: 131 TVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFK 190
            + +  F++L+ L+ L LY N I  +D  AF GL+ L++LYL  N +     D +    K
Sbjct: 100 RIPSGAFEDLENLKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPK 159

Query: 191 LAELMFLDVSYNRIPSMPMHHINLVPG-----KQLRGIYLHGNPFVCDCSLYSLLVFWYR 245
           L  L    +  NRI        +LVPG     + ++ + L  N   CDC      + W  
Sbjct: 160 LERLF---LHNNRI-------THLVPGTFNHLESMKRLRLDSNTLHCDCE-----ILWLA 204

Query: 246 RHFSSVMDFKNDYTCRLWSDSR--HSRQVLLLQDSFMNCSDSIINGSFRALGFIHEAQVG 303
               +  +  N     +    R    R V  +    +NC    I    +      +   G
Sbjct: 205 DLLKTYAESGNAQAAAICEYPRRIQGRSVATITPEELNCERPRITSEPQDA----DVTSG 260

Query: 304 ERLMVHCDSKTGNANTDFIWVGPDNRL-LEPDKEMENFYVFHNGSLVIESPRFEDAGVYS 362
             +   C ++ GN   + IW+  +N L ++ D  +    +  +G+L+I++ +  D G+Y 
Sbjct: 261 NTVYFTCRAE-GNPKPEIIWLRNNNELSMKTDSRLN---LLDDGTLMIQNTQETDQGIYQ 316

Query: 363 CIAMN 367
           C+A N
Sbjct: 317 CMAKN 321



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 81/366 (22%), Positives = 135/366 (36%), Gaps = 55/366 (15%)

Query: 56  NKNLSKVPGNLFRLIKRLDLSY---NRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGS 112
           N  + ++P   F  ++ L   Y   N I  +D +      A L  L L  N I ++   S
Sbjct: 95  NNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQAFK-GLASLEQLYLHFNQIETLDPDS 153

Query: 113 FSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYL 172
           F   P L+ L L +N++  +    F  L+ ++ L L +N + + D      L+ L K Y 
Sbjct: 154 FQHLPKLERLFLHNNRITHLVPGTFNHLESMKRLRLDSNTL-HCDCEILW-LADLLKTYA 211

Query: 173 -SGNF----LTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQLRGIYLHG 227
            SGN     + ++P  +            L+    RI S P                  G
Sbjct: 212 ESGNAQAAAICEYPRRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEG 271

Query: 228 NPFVCDCSLYSLLVFWYRRHFSSVMDFKNDYTCRLWSDSRHSRQVLLLQDS------FMN 281
           NP           + W R +  + +  K D    L  D       L++Q++         
Sbjct: 272 NP--------KPEIIWLRNN--NELSMKTDSRLNLLDDG-----TLMIQNTQETDQGIYQ 316

Query: 282 CSDSIING-------SFRALG------FIHEAQ-----VGERLMVHCDSKTGNANTDFIW 323
           C    + G       + R  G      F+ + Q     VGE + + C S TG+      W
Sbjct: 317 CMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLEC-SATGHPPPRISW 375

Query: 324 VGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGVYSCIAMNKQRLLNETVDVTIN-V 382
              D   L  D  +    +  +G L I++    D+G Y+C A N    ++ T  + +  +
Sbjct: 376 TRGDRTPLPVDPRVN---ITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQAL 432

Query: 383 SNFTVS 388
             FTV+
Sbjct: 433 PQFTVT 438



 Score = 29.6 bits (65), Expect = 7.0
 Identities = 24/90 (26%), Positives = 41/90 (45%), Gaps = 7/90 (7%)

Query: 301 QVGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGV 360
           +VG  + + C S+ G       W     ++ E  K    F++   G L I      DAG 
Sbjct: 537 EVGANVQLPCSSQ-GEPEPAITWNKDGVQVTESGK----FHISPEGFLTINDVGPADAGR 591

Query: 361 YSCIAMNKQRLLNETVDVTINVSNFTVSRS 390
           Y C+A N     + ++ +++NV +  VSR+
Sbjct: 592 YECVARNTIGSASVSMVLSVNVPD--VSRN 619


>gi|4504379 leucine-rich repeat-containing G protein-coupled
           receptor 5 [Homo sapiens]
          Length = 907

 Score = 95.9 bits (237), Expect = 8e-20
 Identities = 68/193 (35%), Positives = 98/193 (50%), Gaps = 11/193 (5%)

Query: 41  CPTACICATD-----IVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKL 95
           CPT C C  D      V C++  LS++P NL      LDLS N I  L    +P S   L
Sbjct: 34  CPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLP-SLRFL 92

Query: 96  NTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISY 155
             L L  N +T I  G+F+   +LK L L +N+L+ V     Q L+ L+ L L  NHISY
Sbjct: 93  EELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISY 152

Query: 156 LDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLV 215
           + PS F GL  L+ L+L  N LT+ P+  +     L+ L  + ++ N+I  +P +    +
Sbjct: 153 VPPSCFSGLHSLRHLWLDDNALTEIPVQAF---RSLSALQAMTLALNKIHHIPDYAFGNL 209

Query: 216 PGKQLRGIYLHGN 228
               L  ++LH N
Sbjct: 210 --SSLVVLHLHNN 220



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 54/185 (29%), Positives = 80/185 (43%), Gaps = 16/185 (8%)

Query: 51  IVSCTNKNLSKVPGNLF---RLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLI---LRHNN 104
           ++   N  L  VP       R ++ L L  N I  +     P  F+ L++L    L  N 
Sbjct: 118 VLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVP----PSCFSGLHSLRHLWLDDNA 173

Query: 105 ITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGL 164
           +T I   +F +   L+ + L+ NK+  + +  F  L  L VL L+NN I  L    F GL
Sbjct: 174 LTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGL 233

Query: 165 SQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQLRGIY 224
             L+ L L+ N L +FP  +      L+ L  L    N I S+P      V    L  I+
Sbjct: 234 HSLETLDLNYNNLDEFPTAIRT----LSNLKELGFHSNNIRSIP--EKAFVGNPSLITIH 287

Query: 225 LHGNP 229
            + NP
Sbjct: 288 FYDNP 292



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 51/158 (32%), Positives = 76/158 (48%), Gaps = 9/158 (5%)

Query: 64  GNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLD 123
           GNL  L+  L L  NRI  L  +        L TL L +NN+    T +  T  NLK L 
Sbjct: 207 GNLSSLVV-LHLHNNRIHSLGKKCFD-GLHSLETLDLNYNNLDEFPT-AIRTLSNLKELG 263

Query: 124 LSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSG-NFLTQFPM 182
             SN ++++    F     L  +  Y+N I ++  SAF  L +L+ L L+G + +T+FP 
Sbjct: 264 FHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFP- 322

Query: 183 DLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQL 220
           DL       A L  L ++  +I S+P    N +P  Q+
Sbjct: 323 DL----TGTANLESLTLTGAQISSLPQTVCNQLPNLQV 356



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 33/88 (37%), Positives = 47/88 (53%), Gaps = 2/88 (2%)

Query: 95  LNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHIS 154
           L  L L +N +  +   SFS    L+ +DL  N++  +K   FQ+L  L  L L  N I+
Sbjct: 354 LQVLDLSYNLLEDLP--SFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIA 411

Query: 155 YLDPSAFGGLSQLQKLYLSGNFLTQFPM 182
            + P+AF  L  L KL LS N L+ FP+
Sbjct: 412 IIHPNAFSTLPSLIKLDLSSNLLSSFPI 439



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 40/131 (30%), Positives = 62/131 (47%), Gaps = 9/131 (6%)

Query: 52  VSCTNKNLSKVPG---NLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSI 108
           ++ T   +S +P    N    ++ LDLSYN +  L S  +     KL  + LRHN I  I
Sbjct: 333 LTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSV---CQKLQKIDLRHNEIYEI 389

Query: 109 STGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQ 168
              +F    +L+ L+L+ NK+  +    F  L  L  L L +N +S    +   GL+ L+
Sbjct: 390 KVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLK 449

Query: 169 KLYLSGNFLTQ 179
              L+GN   Q
Sbjct: 450 ---LTGNHALQ 457



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 26/93 (27%), Positives = 44/93 (47%)

Query: 151 NHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMH 210
           N+IS L P+    L  L++L L+GN LT  P   + G + L  LM  +     +P+  + 
Sbjct: 76  NNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQ 135

Query: 211 HINLVPGKQLRGIYLHGNPFVCDCSLYSLLVFW 243
           ++  +   +L   ++   P  C   L+SL   W
Sbjct: 136 NLRSLQSLRLDANHISYVPPSCFSGLHSLRHLW 168


>gi|31542244 leucine rich repeat and fibronectin type III domain
           containing 5 [Homo sapiens]
          Length = 719

 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 102/417 (24%), Positives = 170/417 (40%), Gaps = 77/417 (18%)

Query: 23  LLCLLMITVTVGPGASGVCPTACICATDIVS------CTNKNLSKVPGNLFRLIKRLDLS 76
           L  L +I + V    + +CP  C+C   I+S      C  K L  VP N+ R    L L+
Sbjct: 5   LFYLFLIGIAV---KAQICPKRCVC--QILSPNLATLCAKKGLLFVPPNIDRRTVELRLA 59

Query: 77  YNRIGLLDSEWIPVSFAKLNTLI---LRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVK 133
            N +  +  +     FA + +L+   L  N I+ I+  +F+   NL+ L L+SN+L  + 
Sbjct: 60  DNFVTNIKRK----DFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKIT 115

Query: 134 NAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAE 193
           N +F  L  L  L+L NN ++ +  +AF  +  L++L LS N L   P D      K+  
Sbjct: 116 NDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVE---KMVS 172

Query: 194 LMFLDVSYNRIPSMP---------MHHINLVPGKQLR----------------------- 221
           L  L + +N I ++P         M  +++   K  +                       
Sbjct: 173 LHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPST 232

Query: 222 -GIYLHGNPFVCDCSLYSLLVFWYRRHFSSVMDFKNDYTCRLWSDSRHSRQVLLLQDSFM 280
             +   GNP  C+C L      W RR     +  ++D            R    + +   
Sbjct: 233 FALSFGGNPLHCNCEL-----LWLRR-----LSREDDLETCASPPLLTGRYFWSIPEEEF 282

Query: 281 NCSDSIINGSFRALGFIHEAQV--GERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEME 338
            C   +I          HE +V  G+R  + C ++ G+      W+ P+ +L+       
Sbjct: 283 LCEPPLIT------RHTHEMRVLEGQRATLRCKAR-GDPEPAIHWISPEGKLI---SNAT 332

Query: 339 NFYVFHNGSLVIESPRFEDAGVYSCIAMNKQRLLNETVDV-TINVSNFTVSRSHAHE 394
              V+ NG+L I     +D G ++CIA N      + VD+  I + +   S +H HE
Sbjct: 333 RSLVYDNGTLDILITTVKDTGAFTCIASNPAGEATQIVDLHIIKLPHLLNSTNHIHE 389


>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
           [Homo sapiens]
          Length = 1093

 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 74/219 (33%), Positives = 104/219 (47%), Gaps = 30/219 (13%)

Query: 12  LGAVVRPGCRELLCLLMIT---VTVGPGASGVCPTACICATDIVSCTNKNLSKVPGNLFR 68
           LGA  R  C  LL LL++    VT   G    C  AC CA D + C  + L+ +PG+L  
Sbjct: 9   LGAPRRSPCLLLLWLLLLRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLAALPGDLPS 68

Query: 69  LIKRLDLSYNRIGLLDS---EWIP-------------------VSFAKLNTLILRHNNIT 106
             + L+LSYN++  +D    E +P                    + + + +L L+HN I 
Sbjct: 69  WTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLQHNKIR 128

Query: 107 SISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQ 166
           S+         +L+ LDLS N +  V+N  F     ++ L L  N I  L+  AF GLS+
Sbjct: 129 SVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSR 188

Query: 167 -LQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRI 204
            L  L LS N +TQ P    V  FKL  L  LD++ NRI
Sbjct: 189 SLLTLRLSKNRITQLP----VRAFKLPRLTQLDLNRNRI 223



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 53/158 (33%), Positives = 78/158 (49%), Gaps = 4/158 (2%)

Query: 50  DIVSCTNKNLSKVPGNLFRL---IKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNIT 106
           +++  +  N+++V    F     IK L+L+ NRIG L+          L TL L  N IT
Sbjct: 142 EVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRIT 201

Query: 107 SISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQ 166
            +   +F   P L  LDL+ N+++ ++   FQ L  LEVL L  N+IS L   AF GLS+
Sbjct: 202 QLPVRAFKL-PRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSK 260

Query: 167 LQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRI 204
           +  L+L  N L +       G   L +L   + S  RI
Sbjct: 261 MHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARI 298



 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 85/321 (26%), Positives = 136/321 (42%), Gaps = 33/321 (10%)

Query: 64  GNLFRL--IKRLDLSYNRIGLLDSE-WIPVSFA-KLNTLILRHNNITSISTGSFSTTPNL 119
           G+L+ L  + +L LS N I  +  + W   SF  KL+ L+L  NN+T +   S +   +L
Sbjct: 277 GSLYGLTALHQLHLSNNSIARIHRKGW---SFCQKLHELVLSFNNLTRLDEESLAELSSL 333

Query: 120 KCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYL---DPSAFGGLSQLQKLYLSGNF 176
             L LS N +  +    F+ L+ L VL L +N IS        AF GL  L KL L GN 
Sbjct: 334 SVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNK 393

Query: 177 LTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSL 236
           +       + G   L  L  L++  N I S+       V  K L+ +++  + F+CDC L
Sbjct: 394 IKSVAKRAFSG---LEGLEHLNLGGNAIRSVQFD--AFVKMKNLKELHISSDSFLCDCQL 448

Query: 237 YSLLVFWYRRHFSSVMDFKNDYTCRLWSDSRHSRQVLLLQDSFMNCSDSIINGSFRALGF 296
             L  +   R   + +      TC    +S   + +  +      C D  +         
Sbjct: 449 KWLPPWLIGRMLQAFV----TATC-AHPESLKGQSIFSVPPESFVC-DDFLKPQIITQPE 502

Query: 297 IHEAQVGERLMVHCDSKTGNAN-TDFIWVGPDNRLLEPDKEMENFYVFH--NGSLV---- 349
              A VG+ +   C + + +++   F W   DN +L  + +MENF   H  +G ++    
Sbjct: 503 TTMAMVGKDIRFTCSAASSSSSPMTFAW-KKDNEVL-TNADMENFVHVHAQDGEVMEYTT 560

Query: 350 ---IESPRFEDAGVYSCIAMN 367
              +    F   G Y C+  N
Sbjct: 561 ILHLRQVTFGHEGRYQCVITN 581



 Score = 36.6 bits (83), Expect = 0.057
 Identities = 76/383 (19%), Positives = 144/383 (37%), Gaps = 71/383 (18%)

Query: 46  ICATDIVSCTNKNLSKVPGNLF---RLIKRLDLSYNRIG--LLDSEWIPVSFAKLNTLIL 100
           + +  ++  ++ ++S +    F   R ++ LDL +N I   + D+         L+ L L
Sbjct: 330 LSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTL 389

Query: 101 RHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVL------LLYNNHIS 154
             N I S++  +FS    L+ L+L  N +++V+   F ++K L+ L       L +  + 
Sbjct: 390 FGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDSFLCDCQLK 449

Query: 155 YLDPSAFGGLSQL-------QKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSM 207
           +L P   G + Q            L G  +   P + +V           D    +I + 
Sbjct: 450 WLPPWLIGRMLQAFVTATCAHPESLKGQSIFSVPPESFVCD---------DFLKPQIITQ 500

Query: 208 PMHHINLVPGKQLRGIYLHGNPFVCDC--SLYSLLVFWYRRHFSSVM--DFKN------- 256
           P   + +V GK +R        F C    S  S + F +++    +   D +N       
Sbjct: 501 PETTMAMV-GKDIR--------FTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQ 551

Query: 257 DYTCRLWSDSRHSRQVLLLQDSFMNCSDSIINGSFRALGFIHEAQVGERLM--------- 307
           D     ++   H RQV    +    C   +I   F +  + H+A++   ++         
Sbjct: 552 DGEVMEYTTILHLRQVTFGHEGRYQC---VITNHFGST-YSHKARLTVNVLPSFTKTPHD 607

Query: 308 ----------VHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFED 357
                     + C + TG+ N    W           +E     +  +    I   + +D
Sbjct: 608 ITIRTTTMARLEC-AATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDD 666

Query: 358 AGVYSCIAMNKQRLLNETVDVTI 380
           AGVYSC A N    ++    +T+
Sbjct: 667 AGVYSCTAQNSAGSISANATLTV 689


>gi|51317373 netrin-G1 ligand [Homo sapiens]
          Length = 640

 Score = 92.4 bits (228), Expect = 9e-19
 Identities = 98/438 (22%), Positives = 166/438 (37%), Gaps = 89/438 (20%)

Query: 23  LLCLLMITVTVGPGASGVCPTACICATDI--VSCTNKNLSKVPGNLFRLIKRLDLSYNRI 80
           +L  L + V  G   +  CP+ C C+     V C  KNL +VP  +    + L+L  N+I
Sbjct: 29  VLLALQLLVVAGLVRAQTCPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQI 88

Query: 81  GLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQEL 140
            ++           L  L L  N+I +I  G+F+   NL  L+L  N+L T+ N  F  L
Sbjct: 89  QIIKVNSFK-HLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYL 147

Query: 141 KVLEVLLLYNN-------------------------HISYLDPSAFGGLS---------- 165
             L+ L L NN                          +SY+   AF GLS          
Sbjct: 148 SKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMC 207

Query: 166 ------------QLQKLYLSGNFLTQFPMDLYVGRFKLAELMF----------------- 196
                       +L +L LSGN L+      + G   L +L                   
Sbjct: 208 NLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQ 267

Query: 197 ----LDVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLLVFWYRRHFSSVM 252
               +++++N +  +P  H    P   L  I+LH NP+ C+C +  L + W+ +  +   
Sbjct: 268 SLVEINLAHNNLTLLP--HDLFTPLHHLERIHLHHNPWNCNCDI--LWLSWWIKDMAP-- 321

Query: 253 DFKNDYTCRLWS--DSRHSRQVLLLQDSFMNCSDSIINGSFRALGFIHEAQVGERLMVHC 310
              N   C   +   +   R +  L  ++  C   +I      +    +  V E +    
Sbjct: 322 --SNTACCARCNTPPNLKGRYIGELDQNYFTCYAPVI------VEPPADLNVTEGMAAEL 373

Query: 311 DSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGVYSCIAMNKQR 370
             +   + T   W+ P+  ++          V  +G+L   +   +D G+Y+C+  N   
Sbjct: 374 KCRASTSLTSVSWITPNGTVMTHGAYKVRIAVLSDGTLNFTNVTVQDTGMYTCMVSNS-- 431

Query: 371 LLNETVDVTINVSNFTVS 388
           + N T   T+NV+  T +
Sbjct: 432 VGNTTASATLNVTAATTT 449


>gi|188528675 slit homolog 1 [Homo sapiens]
          Length = 1534

 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 64/206 (31%), Positives = 95/206 (46%), Gaps = 30/206 (14%)

Query: 37  ASGVCPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLN 96
           +SG CP  C C+  IV C  K L+ +P NL                      P +  ++ 
Sbjct: 278 SSGSCPAMCTCSNGIVDCRGKGLTAIPANL----------------------PETMTEIR 315

Query: 97  TLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYL 156
              L  N I SI  G+FS    L+ +DLS+N++  +    FQ L+ L  L+LY N I+ L
Sbjct: 316 ---LELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDL 372

Query: 157 DPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVP 216
               FGGL  LQ L L+ N +     D +     L  L  L +  N+I S+       + 
Sbjct: 373 PRGVFGGLYTLQLLLLNANKINCIRPDAFQ---DLQNLSLLSLYDNKIQSLAKGTFTSL- 428

Query: 217 GKQLRGIYLHGNPFVCDCSLYSLLVF 242
            + ++ ++L  NPF+CDC+L  L  F
Sbjct: 429 -RAIQTLHLAQNPFICDCNLKWLADF 453



 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 70/227 (30%), Positives = 103/227 (45%), Gaps = 10/227 (4%)

Query: 21  RELLCLLMITVTVGPGASGVCPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRI 80
           R  L LL+       GAS  CP  C C    V C    L  +P N+ R  +RL+L+ N I
Sbjct: 15  RPELWLLLWAAAWRLGASA-CPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNNI 73

Query: 81  GLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQEL 140
             +          +L  L L  N I ++  G+F     L+ L L+ N+L  +   +FQ  
Sbjct: 74  TRIHKNDF-AGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNN 132

Query: 141 KVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFK-LAELMFLDV 199
           + L  L L  N I  +   AF G + L+ L L  N ++     +  G F+ L  L  L +
Sbjct: 133 QALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQIS----CIEEGAFRALRGLEVLTL 188

Query: 200 SYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLLVFWYRR 246
           + N I ++P+   N +P  +LR   LH N   CDC L + L  W R+
Sbjct: 189 NNNNITTIPVSSFNHMP--KLRTFRLHSNHLFCDCHL-AWLSQWLRQ 232



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 41/139 (29%), Positives = 77/139 (55%)

Query: 40  VCPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLI 99
           VCP  C C  ++V C++  L+K+P  + +    L L+ N I +L++  +      L  + 
Sbjct: 512 VCPHKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKIN 571

Query: 100 LRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPS 159
           L +N ++ I  G+F    ++  L L++N+L+++++ +F+ L  L  L+L NN IS +   
Sbjct: 572 LSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHND 631

Query: 160 AFGGLSQLQKLYLSGNFLT 178
           +F GL  ++ L L  N +T
Sbjct: 632 SFTGLRNVRLLSLYDNQIT 650



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 43/135 (31%), Positives = 67/135 (49%), Gaps = 2/135 (1%)

Query: 41  CPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLIL 100
           CP  C C   +V C+NK+L  +P  + + +  L L  N+  L+  +    +F  L  + L
Sbjct: 734 CPQECACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPGQL--STFKYLQLVDL 791

Query: 101 RHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSA 160
            +N I+S+S  SF+    L  L LS N L+ +    FQ L+ L +L L+ N IS L    
Sbjct: 792 SNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGI 851

Query: 161 FGGLSQLQKLYLSGN 175
           F  ++ L  L +  N
Sbjct: 852 FADVTSLSHLAIGAN 866


>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
          Length = 713

 Score = 89.4 bits (220), Expect = 7e-18
 Identities = 103/449 (22%), Positives = 171/449 (38%), Gaps = 106/449 (23%)

Query: 23  LLCLLMITVTVGPGASGV---------------CPTACICATDI--VSCTNKNLSKVPGN 65
           LL L + +  +G G  GV               CP AC C+     V CT ++L++VP +
Sbjct: 24  LLFLWLFSPPLGAGGGGVAVTSAAGGGSPPATSCPVACSCSNQASRVICTRRDLAEVPAS 83

Query: 66  L---------------------FRLIKRLDL--------------------SYNRIGLLD 84
           +                     F+ ++ L++                    S N + L D
Sbjct: 84  IPVNTRYLNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFD 143

Query: 85  SEWIPVS------FAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSS-NKLKTVKNAVF 137
           +    V        +KL  L LR+N I SI + +F+  P+L+ LDL    +L+ +  A F
Sbjct: 144 NRLTTVPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAF 203

Query: 138 Q----------------------ELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGN 175
           +                       L  LE L L  N +  + P +F GL+ L+KL+L   
Sbjct: 204 EGLVNLRYLNLGMCNLKDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHA 263

Query: 176 FLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCS 235
            +     + +     L E   L++S+N + S+P  H    P  +L  ++L+ NP+ C+C 
Sbjct: 264 QVATIERNAFDDLKSLEE---LNLSHNNLMSLP--HDLFTPLHRLERVHLNHNPWHCNCD 318

Query: 236 LYSLLVFWYRRHFSSVMDFKNDYTCRLWSDS-RHSRQVLLLQDSFMNCSDSIINGSFRAL 294
                V W        +        R  + +    R +  L  S   C   +I      +
Sbjct: 319 -----VLWLSWWLKETVPSNTTCCARCHAPAGLKGRYIGELDQSHFTCYAPVI------V 367

Query: 295 GFIHEAQVGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPR 354
               +  V E +      +TG + T   W+ P+  L+          V H+G+L   +  
Sbjct: 368 EPPTDLNVTEGMAAELKCRTGTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGTLNFTNVT 427

Query: 355 FEDAGVYSCIAMNKQRLLNETVDVTINVS 383
            +D G Y+C+  N     N T   T+NVS
Sbjct: 428 VQDTGQYTCMVTNSAG--NTTASATLNVS 454


>gi|4759146 slit homolog 2 [Homo sapiens]
          Length = 1529

 Score = 86.7 bits (213), Expect = 5e-17
 Identities = 59/196 (30%), Positives = 92/196 (46%), Gaps = 30/196 (15%)

Query: 41  CPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLIL 100
           CP AC C+ +IV C  K L+++P NL   I  + L  N I +                  
Sbjct: 273 CPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKV------------------ 314

Query: 101 RHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSA 160
                  I  G+FS    L+ +DLS+N++  +    FQ L+ L  L+LY N I+ L  S 
Sbjct: 315 -------IPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSL 367

Query: 161 FGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQL 220
           F GL  LQ L L+ N +    +D +     L  L  L +  N++ ++     +  P + +
Sbjct: 368 FEGLFSLQLLLLNANKINCLRVDAFQ---DLHNLNLLSLYDNKLQTIAKGTFS--PLRAI 422

Query: 221 RGIYLHGNPFVCDCSL 236
           + ++L  NPF+CDC L
Sbjct: 423 QTMHLAQNPFICDCHL 438



 Score = 82.4 bits (202), Expect = 9e-16
 Identities = 68/244 (27%), Positives = 98/244 (40%), Gaps = 49/244 (20%)

Query: 24  LCLLMITVTVGPGASGVCPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLL 83
           L L ++   +   A   CP  C C+   V C    L  VP N+ R  +RLDL+       
Sbjct: 11  LSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDLN------- 63

Query: 84  DSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVL 143
                              NNIT I+   F+   +L+ L L  NK+ T++   FQ+LK L
Sbjct: 64  ------------------GNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKEL 105

Query: 144 EVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRF-------------- 189
           E L L  NH+       F G ++L +L LS N +   P   + G                
Sbjct: 106 ERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISC 165

Query: 190 -------KLAELMFLDVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLLVF 242
                   L +L  L ++ N I  + +   N +P  +LR   LH N   CDC L + L  
Sbjct: 166 IEDGAFRALRDLEVLTLNNNNITRLSVASFNHMP--KLRTFRLHSNNLYCDCHL-AWLSD 222

Query: 243 WYRR 246
           W R+
Sbjct: 223 WLRQ 226



 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 47/135 (34%), Positives = 68/135 (50%), Gaps = 2/135 (1%)

Query: 41  CPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLIL 100
           CPT C C   +V C+NK L  +P  + R +  L L  N+  L+  E    ++  L  + L
Sbjct: 727 CPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELS--NYKHLTLIDL 784

Query: 101 RHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSA 160
            +N I+++S  SFS    L  L LS N+L+ +    F  LK L +L L+ N IS +   A
Sbjct: 785 SNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGA 844

Query: 161 FGGLSQLQKLYLSGN 175
           F  LS L  L +  N
Sbjct: 845 FNDLSALSHLAIGAN 859



 Score = 75.9 bits (185), Expect = 9e-14
 Identities = 46/162 (28%), Positives = 83/162 (51%)

Query: 41  CPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLIL 100
           CP  C C    V C+N+ L+K+P ++ +    L L+ N   +L++  I     +L  +  
Sbjct: 506 CPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINF 565

Query: 101 RHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSA 160
            +N IT I  G+F     +  + L+SN+L+ V++ +F+ L+ L+ L+L +N I+ +   +
Sbjct: 566 SNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGNDS 625

Query: 161 FGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYN 202
           F GLS ++ L L  N +T      +     L+ L  L   +N
Sbjct: 626 FIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFN 667


>gi|30425553 reticulon 4 receptor-like 1 [Homo sapiens]
          Length = 441

 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 66/184 (35%), Positives = 91/184 (49%), Gaps = 10/184 (5%)

Query: 15  VVRPGCRELLCLLMITVTVGPGASGVCPTACIC--ATDIVSCTNKNLSKVPGNLFRLIKR 72
           ++R GC   L LL++   +  G  G CP  C+C  A   VSC   N + +P  +    +R
Sbjct: 1   MLRKGCCVELLLLLVAAELPLG--GGCPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSER 58

Query: 73  LDLSYNRIGLLDSEWIPVSFAK-LNTLILRHNNITSISTGSFSTTPNLKCLDLSSNK-LK 130
           + L  NRIGLL     P  F+  + TL +  NNIT I   +F    +L+ LDL  N+ L+
Sbjct: 59  VFLQNNRIGLLQ----PGHFSPAMVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLR 114

Query: 131 TVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFK 190
           T+    FQ L  L  L LY   +S L    FGGL  LQ LYL  N +     D++V    
Sbjct: 115 TLAPETFQGLVKLHALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVN 174

Query: 191 LAEL 194
           L+ L
Sbjct: 175 LSHL 178



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 40/120 (33%), Positives = 57/120 (47%), Gaps = 4/120 (3%)

Query: 59  LSKVPGNLFRLIKRLDLSY---NRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFST 115
           LS +P  +F  +  L   Y   N I  L  + I V    L+ L L  N + S+  G+F  
Sbjct: 137 LSALPAGVFGGLHSLQYLYLQDNHIEYLQDD-IFVDLVNLSHLFLHGNKLWSLGPGTFRG 195

Query: 116 TPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGN 175
             NL  L L  N+L+ V +  F +L+ L  L L+NN +S L       L  L+ L L+GN
Sbjct: 196 LVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGN 255



 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 50/190 (26%), Positives = 77/190 (40%), Gaps = 36/190 (18%)

Query: 95  LNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHIS 154
           L  L L+ N+I  +    F    NL  L L  NKL ++    F+ L  L+ LLL+ N + 
Sbjct: 151 LQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRGLVNLDRLLLHENQLQ 210

Query: 155 YLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINL 214
           ++   AF  L +L  L+L  N L++   +                              L
Sbjct: 211 WVHHKAFHDLRRLTTLFLFNNSLSELQGEC-----------------------------L 241

Query: 215 VPGKQLRGIYLHGNPFVCDCSLYSLLVFWYRRHFSSVMDFKNDYTCRLWSDSRHSRQVLL 274
            P   L  + L+GNP+ C C   SL   W +R   S     +   C +    RH + + L
Sbjct: 242 APLGALEFLRLNGNPWDCGCRARSLWE-WLQRFRGS----SSAVPC-VSPGLRHGQDLKL 295

Query: 275 LQ-DSFMNCS 283
           L+ + F NC+
Sbjct: 296 LRAEDFRNCT 305


>gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo
           sapiens]
          Length = 516

 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 69/218 (31%), Positives = 104/218 (47%), Gaps = 16/218 (7%)

Query: 35  PGASGVCPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAK 94
           P     CP  C C   +  C ++    VP    +    L L +N I  L+ +    SF++
Sbjct: 28  PALGMACPPKCRCEKLLFYCDSQGFHSVPNATDKGSLGLSLRHNHITELERDQF-ASFSQ 86

Query: 95  LNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHIS 154
           L  L L HN I+++   +F     LK L LSSNK+  + N  F +L  L+ L L  N +S
Sbjct: 87  LTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLS 146

Query: 155 YLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMH-HIN 213
            L P  F GL +LQ L+L  N L   P+ L+   +    L FLD+S NR+ S+  +    
Sbjct: 147 SLHPELFYGLRKLQTLHLRSNSLRTIPVRLF---WDCRSLEFLDLSTNRLRSLARNGFAG 203

Query: 214 LVPGKQLRGIYLHGNP--------FVCDCSLYSLLVFW 243
           L+   +LR ++L  N         F+   SL++L + W
Sbjct: 204 LI---KLRELHLEHNQLTKINFAHFLRLSSLHTLFLQW 238



 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 58/212 (27%), Positives = 96/212 (45%), Gaps = 23/212 (10%)

Query: 70  IKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKL 129
           ++ LDLS+N++  L  E       KL TL LR N++ +I    F    +L+ LDLS+N+L
Sbjct: 135 LQNLDLSFNQLSSLHPELF-YGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRL 193

Query: 130 KTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQF--------- 180
           +++    F  L  L  L L +N ++ ++ + F  LS L  L+L  N ++           
Sbjct: 194 RSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWG 253

Query: 181 ---PMDLYVGRFKLAELMFLDVSYN-RIPSMPMHHINLVPGK------QLRGIYLHGNPF 230
               +DL     K  +L   +   N +I  M  + +N +  K       L  + L GN +
Sbjct: 254 TLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGNLW 313

Query: 231 VCD---CSLYSLLVFWYRRHFSSVMDFKNDYT 259
            C    C+L S L  +  R   S++    D+T
Sbjct: 314 ECSARICALASWLGSFQGRWEHSILCHSPDHT 345



 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 44/146 (30%), Positives = 74/146 (50%), Gaps = 26/146 (17%)

Query: 56  NKNLSKVPGNLF---RLIKRLDLSYNRI---------GLLD--------SEWIPVSFA-- 93
           + +L  +P  LF   R ++ LDLS NR+         GL+         ++   ++FA  
Sbjct: 166 SNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHF 225

Query: 94  ----KLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLY 149
                L+TL L+ N I++++ G   T   L+ LDL+ N++K +   VF+ +  L++LL+ 
Sbjct: 226 LRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMD 285

Query: 150 NNHISYLDPSAFGGLSQLQKLYLSGN 175
           NN ++ LD      L  L  + LSGN
Sbjct: 286 NNKLNSLDSKILNSLRSLTTVGLSGN 311


>gi|40217823 SLIT and NTRK-like family, member 5 [Homo sapiens]
          Length = 958

 Score = 83.6 bits (205), Expect = 4e-16
 Identities = 71/212 (33%), Positives = 108/212 (50%), Gaps = 24/212 (11%)

Query: 40  VCPTACICATD----IVSCTNK---NLSKVPGNLFRLIKRLDLSYNRIG-LLDSEWIPVS 91
           +C  AC C        VSC N+   +LS++    F +   L LS N +  L  +E+  V+
Sbjct: 47  ICDNACPCEEKDGILTVSCENRGIISLSEISPPRFPIYHLL-LSGNLLNRLYPNEF--VN 103

Query: 92  FAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNN 151
           +   + L L  N I  I TG+F     L+ L L++NKL+ +++  F  L+ LE L +  N
Sbjct: 104 YTGASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYN 163

Query: 152 HISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMP--- 208
           +IS ++P+AFG L  LQ L L+ N L+  P +L    F+   L  LD+  NR+  +P   
Sbjct: 164 YISVIEPNAFGKLHLLQVLILNDNLLSSLPNNL----FRFVPLTHLDLRGNRLKLLPYVG 219

Query: 209 -MHHINLVPGKQLRGIYLHGNPFVCDCSLYSL 239
            + H++ V   Q     L  NP+ C C L SL
Sbjct: 220 LLQHMDKVVELQ-----LEENPWNCSCELISL 246



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 58/211 (27%), Positives = 96/211 (45%), Gaps = 22/211 (10%)

Query: 41  CPTACICATDI------VSCTNKNLSKV------PGNLFRLIKRLDLSYNRIGLLDSEWI 88
           CPTAC C   I      V+C  + +  +      P N     K++ L+ N I ++     
Sbjct: 374 CPTACSCNLQISDLGLNVNCQERKIESIAELQPKPYN----PKKMYLTENYIAVVRRTDF 429

Query: 89  PVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLL 148
            +    L+ L L +N I+ I   +F    NL+ L L+ N+++ +   +F  L+ L+ L L
Sbjct: 430 -LEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPELFYGLQSLQYLFL 488

Query: 149 YNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMP 208
             N I  +    F  +  LQ L+L+ N L   P  ++ G      L+ L++  N   S+P
Sbjct: 489 QYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSG----LTLLRLNLRSNHFTSLP 544

Query: 209 MHHINLVPGKQLRGIYLHGNPFVCDCSLYSL 239
           +  + L   K L  I LH NP+ C C +  +
Sbjct: 545 VSGV-LDQLKSLIQIDLHDNPWDCTCDIVGM 574


>gi|11321571 slit homolog 3 [Homo sapiens]
          Length = 1523

 Score = 83.2 bits (204), Expect = 5e-16
 Identities = 56/196 (28%), Positives = 90/196 (45%), Gaps = 30/196 (15%)

Query: 41  CPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLIL 100
           CP+ C C+ +IV C  K L ++P NL                      P    ++    L
Sbjct: 280 CPSPCTCSNNIVDCRGKGLMEIPANL----------------------PEGIVEIR---L 314

Query: 101 RHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSA 160
             N+I +I  G+F+    LK +D+S N++  +    FQ LK L  L+LY N I+ +    
Sbjct: 315 EQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGL 374

Query: 161 FGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQL 220
           F GL  LQ L L+ N +    ++ +     L  L  L +  N++ ++        P + +
Sbjct: 375 FDGLVSLQLLLLNANKINCLRVNTFQ---DLQNLNLLSLYDNKLQTISKG--LFAPLQSI 429

Query: 221 RGIYLHGNPFVCDCSL 236
           + ++L  NPFVCDC L
Sbjct: 430 QTLHLAQNPFVCDCHL 445



 Score = 82.4 bits (202), Expect = 9e-16
 Identities = 62/208 (29%), Positives = 95/208 (45%), Gaps = 32/208 (15%)

Query: 40  VCPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLI 99
           VCP  C C   IV C+N+ L ++P +L   +  L L+ N + +L++              
Sbjct: 504 VCPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEA-------------- 549

Query: 100 LRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPS 159
                     TG F   PNL+ ++LS+NK+K V+   F     ++ L+L  N +  +   
Sbjct: 550 ----------TGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGR 599

Query: 160 AFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSM-PMHHINLVPGK 218
            F GLS L+ L L  N +     D + G   L+ +  L +  NRI ++ P     LV   
Sbjct: 600 VFRGLSGLKTLMLRSNLIGCVSNDTFAG---LSSVRLLSLYDNRITTITPGAFTTLV--- 653

Query: 219 QLRGIYLHGNPFVCDCSLYSLLVFWYRR 246
            L  I L  NPF C+C L + L  W R+
Sbjct: 654 SLSTINLLSNPFNCNCHL-AWLGKWLRK 680



 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 74/256 (28%), Positives = 105/256 (41%), Gaps = 52/256 (20%)

Query: 12  LGAVVRPGCRELLCLLMITVTVGPGASGVCPTACICATDIVSCTNKNLSKVPGNLFRLIK 71
           +GA VR   R  L L + +V  GP A   CPT C C+   V C    L  VP  + R  +
Sbjct: 8   VGAAVR--ARLALALALASVLSGPPAVA-CPTKCTCSAASVDCHGLGLRAVPRGIPRNAE 64

Query: 72  RLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKT 131
           RLDL                           NNIT I+   F+   NL+ L L  N++  
Sbjct: 65  RLDLD-------------------------RNNITRITKMDFAGLKNLRVLHLEDNQVSV 99

Query: 132 VKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLY------ 185
           ++   FQ+LK LE L L  N +  L    F    +L +L LS N +   P   +      
Sbjct: 100 IERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDV 159

Query: 186 --------------VGRFK-LAELMFLDVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPF 230
                          G F+ L +L  L ++ N I  + +   N +P  ++R + LH N  
Sbjct: 160 KNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMP--KIRTLRLHSNHL 217

Query: 231 VCDCSLYSLLVFWYRR 246
            CDC L + L  W R+
Sbjct: 218 YCDCHL-AWLSDWLRQ 232



 Score = 66.6 bits (161), Expect = 5e-11
 Identities = 44/136 (32%), Positives = 69/136 (50%), Gaps = 4/136 (2%)

Query: 41  CPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLI- 99
           CP  C C   +V C+NK L  +P  + + +  L L  N +  +  E   +S  +  TLI 
Sbjct: 725 CPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRE---LSALRHLTLID 781

Query: 100 LRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPS 159
           L +N+I+ ++  +FS   +L  L LS N+L+ +    F  L+ L VL L+ N IS +   
Sbjct: 782 LSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEG 841

Query: 160 AFGGLSQLQKLYLSGN 175
           +F  L+ L  L L  N
Sbjct: 842 SFNDLTSLSHLALGTN 857


>gi|157694513 leucine-rich repeat-containing G protein-coupled
           receptor 4 [Homo sapiens]
          Length = 951

 Score = 82.8 bits (203), Expect = 7e-16
 Identities = 67/229 (29%), Positives = 93/229 (40%), Gaps = 30/229 (13%)

Query: 18  PGCRELLCLLMITVTVGPGASGVCPTACI--CATD---IVSCTNKNLSKVPGNLFRLIKR 72
           PG   LLC L + +    G SG  P  C   C+ D    V C+ K L+ VP  L    + 
Sbjct: 2   PGPLGLLCFLALGLLGSAGPSGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQA 61

Query: 73  LDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTV 132
           LD+S N                         NIT +   +F   P L+ L L+ N L  +
Sbjct: 62  LDISMN-------------------------NITQLPEDAFKNFPFLEELQLAGNDLSFI 96

Query: 133 KNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLA 192
                  LK L+VL L NN +  +   A  GLS LQ L L  N +T  P D + G  +L 
Sbjct: 97  HPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLR 156

Query: 193 ELMFLDVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLLV 241
            L   D S   +P  P+ ++  +    L    +   P     +L SL+V
Sbjct: 157 HLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVV 205



 Score = 63.2 bits (152), Expect = 6e-10
 Identities = 57/194 (29%), Positives = 87/194 (44%), Gaps = 12/194 (6%)

Query: 51  IVSCTNKNLSKVPGNLFR---LIKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITS 107
           +++  N  L  VP    R    ++ L L  N I  +  +       +L  L L  N++T 
Sbjct: 109 VLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFE-GLVQLRHLWLDDNSLTE 167

Query: 108 ISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQL 167
           +     S  P L+ L L+ NK+ ++ +  F  L  L VL L+NN I  L    F GL  L
Sbjct: 168 VPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNL 227

Query: 168 QKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQLRGIYLHG 227
           + L L+ N L +FP  +      L  L  L    N I  +P    +  P   LR I+L+ 
Sbjct: 228 ETLDLNYNNLGEFPQAIKA----LPSLKELGFHSNSISVIPDGAFDGNP--LLRTIHLYD 281

Query: 228 NP--FVCDCSLYSL 239
           NP  FV + + ++L
Sbjct: 282 NPLSFVGNSAFHNL 295



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 39/128 (30%), Positives = 61/128 (47%), Gaps = 9/128 (7%)

Query: 52  VSCTNKNLSKVPGNLF---RLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSI 108
           ++ T   +S +P NL    ++++ LDLSYN I  L S         L  + L+ N I  I
Sbjct: 324 LTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPSF---NGCHALEEISLQRNQIYQI 380

Query: 109 STGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQ 168
             G+F    +L+ LDLS N +  + +  F  L  +  L +  N ++        GL+QL+
Sbjct: 381 KEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLK 440

Query: 169 KLYLSGNF 176
              L GNF
Sbjct: 441 ---LVGNF 445



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 34/113 (30%), Positives = 52/113 (46%), Gaps = 4/113 (3%)

Query: 95  LNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHIS 154
           L TL L +NN+      +    P+LK L   SN +  + +  F    +L  + LY+N +S
Sbjct: 227 LETLDLNYNNLGEFPQ-AIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLS 285

Query: 155 YLDPSAFGGLSQLQKLYLSG-NFLTQFPMDLYVGRFKLAELMFLDVSYNRIPS 206
           ++  SAF  LS L  L + G + + QFP     G   L  L       + IP+
Sbjct: 286 FVGNSAFHNLSDLHSLVIRGASMVQQFPN--LTGTVHLESLTLTGTKISSIPN 336



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 37/109 (33%), Positives = 51/109 (46%), Gaps = 10/109 (9%)

Query: 95  LNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHIS 154
           L TL L +NNI  +   SF+    L+ + L  N++  +K   FQ L  L +L L  N I 
Sbjct: 345 LRTLDLSYNNIRDLP--SFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIH 402

Query: 155 YLDPSAFGGLSQLQKLYLSGNFLTQFPMD--------LYVGRFKLAELM 195
            +   AF  L  +  L +S N LT FP +          VG FKL E +
Sbjct: 403 EIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLKLVGNFKLKEAL 451



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 35/119 (29%), Positives = 52/119 (43%), Gaps = 5/119 (4%)

Query: 95  LNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHIS 154
           L +L L    I+SI          L+ LDLS N ++ + +  F     LE + L  N I 
Sbjct: 321 LESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPS--FNGCHALEEISLQRNQIY 378

Query: 155 YLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMHHIN 213
            +    F GL  L+ L LS N + +     +     L  +  LDVS+N + S P   +N
Sbjct: 379 QIKEGTFQGLISLRILDLSRNLIHEIHSRAFA---TLGPITNLDVSFNELTSFPTEGLN 434


>gi|4826772 insulin-like growth factor binding protein, acid labile
           subunit isoform 2 precursor [Homo sapiens]
          Length = 605

 Score = 82.4 bits (202), Expect = 9e-16
 Identities = 92/343 (26%), Positives = 150/343 (43%), Gaps = 78/343 (22%)

Query: 16  VRPGCRELLCLLMITVTVGP--------GASG-----VCPTACICATD------IVSCTN 56
           +R G   L  LL+  V +GP        G  G      CP AC+C+ D       V C++
Sbjct: 3   LRKGGLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSS 62

Query: 57  KNLSKVP-------------GNLFRLIKR-----------LDLSYNRIGLLDSEWIPVSF 92
           +NL+++P             GN    +             L+L   ++G L+ + + +  
Sbjct: 63  RNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQAL-LGL 121

Query: 93  AKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNH 152
             L  L L  N + S++ G+F+ TP L  L LS+N+L  +++ +F+ L  L  L L  N 
Sbjct: 122 ENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNS 181

Query: 153 ISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMHHI 212
           ++ L  +AF GL  L++L L+GN L      L+ G   LAEL  LD+S N + ++  +  
Sbjct: 182 LAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSG---LAELRELDLSRNALRAIKANVF 238

Query: 213 NLVPGKQLRGIYLHGNPFVCDCSLYSLLVFWYRRHFSSVMDFKNDYTCRLWSDSRHSRQV 272
             +P  +L+ +YL  N          L+       F  +   +       W D  H+R  
Sbjct: 239 VQLP--RLQKLYLDRN----------LIAAVAPGAFLGLKALR-------WLDLSHNRVA 279

Query: 273 LLLQDSF------------MNCSDSIINGSFRALGFIHEAQVG 303
            LL+D+F             N   S+   +F+ L F+ E Q+G
Sbjct: 280 GLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLG 322



 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 64/238 (26%), Positives = 100/238 (42%), Gaps = 68/238 (28%)

Query: 70  IKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKL 129
           ++ L L +NRI  L +E       +L  L L HN +  +  G+F    N+  ++LS N L
Sbjct: 316 LEELQLGHNRIRQL-AERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL 374

Query: 130 KTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLY------------------ 171
           + +   VF+ L  L  L L  + +  + P  F GLS L++L+                  
Sbjct: 375 RNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLA 434

Query: 172 ------LSGNFLTQFPMDLYVG----------RFKLAEL-----------MFLDVSYNRI 204
                 L+ N LT  P  L+ G          R +LAEL            +LDVS+NR+
Sbjct: 435 ELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRL 494

Query: 205 PSMP---------MHHINL-----------VPGKQLRGIYLHGNPFVCDCSLYSLLVF 242
            ++P         + +++L            PG  L  ++L GNP+ C C L +L  F
Sbjct: 495 EALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPG--LERLWLEGNPWDCGCPLKALRDF 550



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 42/127 (33%), Positives = 64/127 (50%), Gaps = 1/127 (0%)

Query: 68  RLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSN 127
           + ++ LDLS+NR+  L  +  P     L  L L HN I S+   +F     L+ L L  N
Sbjct: 266 KALRWLDLSHNRVAGLLEDTFP-GLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHN 324

Query: 128 KLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVG 187
           +++ +    F+ L  LEVL L +N +  +   AF GL+ +  + LSGN L   P  ++ G
Sbjct: 325 RIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRG 384

Query: 188 RFKLAEL 194
             KL  L
Sbjct: 385 LGKLHSL 391



 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 41/135 (30%), Positives = 67/135 (49%), Gaps = 4/135 (2%)

Query: 70  IKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKL 129
           ++ LDLS N +  + +  + V   +L  L L  N I +++ G+F     L+ LDLS N++
Sbjct: 220 LRELDLSRNALRAIKAN-VFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRV 278

Query: 130 KTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRF 189
             +    F  L  L VL L +N I+ L P  F  L  L++L L  N + Q     + G  
Sbjct: 279 AGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEG-- 336

Query: 190 KLAELMFLDVSYNRI 204
            L +L  L + +N++
Sbjct: 337 -LGQLEVLTLDHNQL 350


>gi|52353306 leucine rich repeat containing 55 [Homo sapiens]
          Length = 341

 Score = 82.4 bits (202), Expect = 9e-16
 Identities = 68/276 (24%), Positives = 116/276 (42%), Gaps = 32/276 (11%)

Query: 23  LLCLLMITVTVGPGASGVCPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGL 82
           L+ LL+    +   A   CP  C C   +V C+++ L  VP +L    + L L++NRI  
Sbjct: 63  LISLLLAAGLMHSDAGTSCPVLCTCRNQVVDCSSQRLFSVPPDLPMDTRNLSLAHNRITA 122

Query: 83  LDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELK- 141
           +   ++   + +L  L L +N++  +  G F     L  LDLS N    V   +FQE   
Sbjct: 123 VPPGYL-TCYMELQVLDLHNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAHG 181

Query: 142 VLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSY 201
           ++ + L +N  +  + P AF GL QL+                            LD+SY
Sbjct: 182 LVHIDLSHNPWLRRVHPQAFQGLMQLRD---------------------------LDLSY 214

Query: 202 NRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLLVFWYRRHFSSVMDFKNDYTCR 261
             +  + +  +  +PG  L  + + GNP+VC C++  LL  W R              CR
Sbjct: 215 GGLAFLSLEALEGLPG--LVTLQIGGNPWVCGCTMEPLLK-WLRNRIQRCTADSQLAECR 271

Query: 262 LWSDSRHSRQVLLLQDSFMNCSDSIINGSFRALGFI 297
              +   +    L ++SF  C  ++    +  + F+
Sbjct: 272 GPPEVEGAPLFSLTEESFKACHLTLTLDDYLFIAFV 307


>gi|229089140 leucine rich repeat containing 24 [Homo sapiens]
          Length = 513

 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 65/214 (30%), Positives = 103/214 (48%), Gaps = 6/214 (2%)

Query: 26  LLMITVTVGPGASGVCPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLDS 85
           LL + + + P  +  CP AC C +  V C    L  VP  +    + L L  N I  L+ 
Sbjct: 8   LLPLLLLLLPLRAAGCPAACRCYSATVECGALRLRVVPLGIPPGTQTLFLQDNNIARLEP 67

Query: 86  EWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEV 145
             +    A L  L L +N++ ++  G+F   P L  L L+SN+L+ +++  F  L  L V
Sbjct: 68  GAL-APLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRV 126

Query: 146 LLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIP 205
           L L  N ++ L    F  L +LQ+L+L  N +         G   L+ L  LD+S N++ 
Sbjct: 127 LYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAG---LSSLALLDLSRNQLG 183

Query: 206 SMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSL 239
           ++      L P   L+ + L  NP+ CDC+L+ L
Sbjct: 184 TISRE--ALQPLASLQVLRLTENPWRCDCALHWL 215


>gi|225579152 insulin-like growth factor binding protein, acid
           labile subunit isoform 1 precursor [Homo sapiens]
          Length = 643

 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 84/314 (26%), Positives = 139/314 (44%), Gaps = 65/314 (20%)

Query: 32  TVGPGASGVCPTACICATD------IVSCTNKNLSKVP-------------GNLFRLIKR 72
           T G      CP AC+C+ D       V C+++NL+++P             GN    +  
Sbjct: 70  TPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPP 129

Query: 73  -----------LDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKC 121
                      L+L   ++G L+ + + +    L  L L  N + S++ G+F+ TP L  
Sbjct: 130 AAFQNLSSLGFLNLQGGQLGSLEPQAL-LGLENLCHLHLERNQLRSLALGTFAHTPALAS 188

Query: 122 LDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFP 181
           L LS+N+L  +++ +F+ L  L  L L  N ++ L  +AF GL  L++L L+GN L    
Sbjct: 189 LGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQ 248

Query: 182 MDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLLV 241
             L+ G   LAEL  LD+S N + ++  +    +P  +L+ +YL  N          L+ 
Sbjct: 249 PALFSG---LAELRELDLSRNALRAIKANVFVQLP--RLQKLYLDRN----------LIA 293

Query: 242 FWYRRHFSSVMDFKNDYTCRLWSDSRHSRQVLLLQDSF------------MNCSDSIING 289
                 F  +   +       W D  H+R   LL+D+F             N   S+   
Sbjct: 294 AVAPGAFLGLKALR-------WLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPR 346

Query: 290 SFRALGFIHEAQVG 303
           +F+ L F+ E Q+G
Sbjct: 347 TFKDLHFLEELQLG 360



 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 64/238 (26%), Positives = 100/238 (42%), Gaps = 68/238 (28%)

Query: 70  IKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKL 129
           ++ L L +NRI  L +E       +L  L L HN +  +  G+F    N+  ++LS N L
Sbjct: 354 LEELQLGHNRIRQL-AERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL 412

Query: 130 KTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLY------------------ 171
           + +   VF+ L  L  L L  + +  + P  F GLS L++L+                  
Sbjct: 413 RNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLA 472

Query: 172 ------LSGNFLTQFPMDLYVG----------RFKLAEL-----------MFLDVSYNRI 204
                 L+ N LT  P  L+ G          R +LAEL            +LDVS+NR+
Sbjct: 473 ELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRL 532

Query: 205 PSMP---------MHHINL-----------VPGKQLRGIYLHGNPFVCDCSLYSLLVF 242
            ++P         + +++L            PG  L  ++L GNP+ C C L +L  F
Sbjct: 533 EALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPG--LERLWLEGNPWDCGCPLKALRDF 588



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 42/127 (33%), Positives = 64/127 (50%), Gaps = 1/127 (0%)

Query: 68  RLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSN 127
           + ++ LDLS+NR+  L  +  P     L  L L HN I S+   +F     L+ L L  N
Sbjct: 304 KALRWLDLSHNRVAGLLEDTFP-GLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHN 362

Query: 128 KLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVG 187
           +++ +    F+ L  LEVL L +N +  +   AF GL+ +  + LSGN L   P  ++ G
Sbjct: 363 RIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRG 422

Query: 188 RFKLAEL 194
             KL  L
Sbjct: 423 LGKLHSL 429



 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 41/135 (30%), Positives = 67/135 (49%), Gaps = 4/135 (2%)

Query: 70  IKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKL 129
           ++ LDLS N +  + +  + V   +L  L L  N I +++ G+F     L+ LDLS N++
Sbjct: 258 LRELDLSRNALRAIKAN-VFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRV 316

Query: 130 KTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRF 189
             +    F  L  L VL L +N I+ L P  F  L  L++L L  N + Q     + G  
Sbjct: 317 AGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEG-- 374

Query: 190 KLAELMFLDVSYNRI 204
            L +L  L + +N++
Sbjct: 375 -LGQLEVLTLDHNQL 388


>gi|41582239 immunoglobulin superfamily containing leucine-rich
           repeat [Homo sapiens]
          Length = 428

 Score = 79.3 bits (194), Expect = 8e-15
 Identities = 92/368 (25%), Positives = 143/368 (38%), Gaps = 60/368 (16%)

Query: 36  GASGVCPTACICAT----DIVSCTNKNLSKVPGNLFRLIKRLDLSYNRI-GLLDSEWIPV 90
           G +  CP  C C       I  C  ++L  VP      +  L LS NR+ GL +  +  V
Sbjct: 14  GLAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREV 73

Query: 91  SFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYN 150
               L +L L HN I +++ G+ ++  +LK LDLS N +     +    L  L++L + +
Sbjct: 74  PL--LQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDS 131

Query: 151 NHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMH 210
           N ++++   AF  L  L+ L L+ N L             LAE  F              
Sbjct: 132 NELTFIPRDAFRSLRALRSLQLNHNRL-----------HTLAEGTF-------------- 166

Query: 211 HINLVPGKQLRGIYLHGNPFVCDCSLYSLLVFWYRRHFSSVMDFKNDYTCRLWSDSRHSR 270
                P   L  + ++ NPF C C +  L   W      S+ + +++  C   +     +
Sbjct: 167 ----TPLTALSHLQINENPFDCTCGIVWLKT-WALTTAVSIPE-QDNIAC---TSPHVLK 217

Query: 271 QVLLLQDSFMNCSDSIINGSFRALGFIHEAQVGERLMVHCDSKTGNANTDFIW------- 323
              L +   + CS   +  S++      E + G  L +HCD   G       W       
Sbjct: 218 GTPLSRLPPLPCSAPSVQLSYQPSQDGAELRPGFVLALHCD-VDGQPAPQLHWHIQIPSG 276

Query: 324 --------VGPDNRLLEPD---KEMENFYVFHNGSLVIESPRFEDAGVYSCIAMNKQRLL 372
                   VG D R L           F  F NGSL+I      + G YSC+A N+    
Sbjct: 277 IVEITSPNVGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSA 336

Query: 373 NETVDVTI 380
             +VDV +
Sbjct: 337 ESSVDVAL 344


>gi|5031809 immunoglobulin superfamily containing leucine-rich
           repeat [Homo sapiens]
          Length = 428

 Score = 79.3 bits (194), Expect = 8e-15
 Identities = 92/368 (25%), Positives = 143/368 (38%), Gaps = 60/368 (16%)

Query: 36  GASGVCPTACICAT----DIVSCTNKNLSKVPGNLFRLIKRLDLSYNRI-GLLDSEWIPV 90
           G +  CP  C C       I  C  ++L  VP      +  L LS NR+ GL +  +  V
Sbjct: 14  GLAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREV 73

Query: 91  SFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYN 150
               L +L L HN I +++ G+ ++  +LK LDLS N +     +    L  L++L + +
Sbjct: 74  PL--LQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDS 131

Query: 151 NHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMH 210
           N ++++   AF  L  L+ L L+ N L             LAE  F              
Sbjct: 132 NELTFIPRDAFRSLRALRSLQLNHNRL-----------HTLAEGTF-------------- 166

Query: 211 HINLVPGKQLRGIYLHGNPFVCDCSLYSLLVFWYRRHFSSVMDFKNDYTCRLWSDSRHSR 270
                P   L  + ++ NPF C C +  L   W      S+ + +++  C   +     +
Sbjct: 167 ----TPLTALSHLQINENPFDCTCGIVWLKT-WALTTAVSIPE-QDNIAC---TSPHVLK 217

Query: 271 QVLLLQDSFMNCSDSIINGSFRALGFIHEAQVGERLMVHCDSKTGNANTDFIW------- 323
              L +   + CS   +  S++      E + G  L +HCD   G       W       
Sbjct: 218 GTPLSRLPPLPCSAPSVQLSYQPSQDGAELRPGFVLALHCD-VDGQPAPQLHWHIQIPSG 276

Query: 324 --------VGPDNRLLEPD---KEMENFYVFHNGSLVIESPRFEDAGVYSCIAMNKQRLL 372
                   VG D R L           F  F NGSL+I      + G YSC+A N+    
Sbjct: 277 IVEITSPNVGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSA 336

Query: 373 NETVDVTI 380
             +VDV +
Sbjct: 337 ESSVDVAL 344


>gi|149773484 leucine rich repeat and fibronectin type III domain
           containing 1 [Homo sapiens]
          Length = 771

 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 95/389 (24%), Positives = 153/389 (39%), Gaps = 58/389 (14%)

Query: 28  MITVTVGPGASGVCPTACICA----TDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLL 83
           ++ +  G      CP  CIC     T  + C    L  VP  + R +  L L+ N I  +
Sbjct: 21  LLLLWAGASRGQPCPGRCICQNVAPTLTMLCAKTGLLFVPPAIDRRVVELRLTDNFIAAV 80

Query: 84  DSEWIPVSFAKLNTLI---LRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQEL 140
                   FA + +L+   L  N I  ++ G+F+    L+ L L SN+L  V+    + L
Sbjct: 81  RRR----DFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQLRGL 136

Query: 141 KVLEVLLLYNNHISYLDPSAFGG-LSQLQKLYLSGNFLTQFPMD---------------- 183
             L  L+L NN I  ++ +AF   LS ++ L LS N L   P +                
Sbjct: 137 GNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHN 196

Query: 184 ----LYVGRF-KLAELMFLDVSYNRIPSMPMHHINL-------VPGKQLRGIYLHGNPFV 231
               +  G F +L +L+ LD++ NR+  +P   + L        P   L  +   GNP  
Sbjct: 197 LIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFLRSQGTGPKPPTPLT-VSFGGNPLH 255

Query: 232 CDCSLYSLLVFWYRRHFSSVMDFKNDYTCRLWSDSRHSRQVLLLQDSFMNCSDSIINGSF 291
           C+C L      W RR     +  ++D       +    R    + +    C   +I    
Sbjct: 256 CNCEL-----LWLRR-----LTREDDLETCATPEHLTDRYFWSIPEEEFLCEPPLITRQA 305

Query: 292 RALGFIHEAQVGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIE 351
                + E   G+ + + C +  G+      WV PD RLL          V  +G+L + 
Sbjct: 306 GGRALVVE---GQAVSLRCRA-VGDPEPVVHWVAPDGRLLGNSSRTR---VRGDGTLDVT 358

Query: 352 SPRFEDAGVYSCIAMNKQRLLNETVDVTI 380
                D+G ++CIA N        V+V +
Sbjct: 359 ITTLRDSGTFTCIASNAAGEATAPVEVCV 387


>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
           sapiens]
          Length = 593

 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 57/197 (28%), Positives = 90/197 (45%), Gaps = 3/197 (1%)

Query: 27  LMITVTVGPGASGVCPTACICATD--IVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLD 84
           L+  + +  G+ G CP  C C +    V C ++ L  VPG L    + LDLS NR+  L 
Sbjct: 17  LLFLLLLPGGSGGSCPAVCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQ 76

Query: 85  SEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLE 144
              +    + L  L L +N ++++  G+F    +L  L L  N+L+ +   VF  L  L 
Sbjct: 77  QGMLS-RLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALT 135

Query: 145 VLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRI 204
           +L L  N I      AFG L  LQKL +  N L       + G  KL+ L     + + +
Sbjct: 136 LLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTV 195

Query: 205 PSMPMHHINLVPGKQLR 221
           P + +  +  +   +LR
Sbjct: 196 PGLALARLPALVALRLR 212



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 67/258 (25%), Positives = 95/258 (36%), Gaps = 30/258 (11%)

Query: 118 NLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFL 177
           NL  L ++   L +V       L  L VL L  N IS +       L +LQ+L LSG  L
Sbjct: 253 NLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGACL 312

Query: 178 TQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLY 237
           T      + G   L     LDV+ N + ++           +L  + L GNP  CDC L 
Sbjct: 313 TSIAAHAFHG---LTAFHLLDVADNALQTL--EETAFPSPDKLVTLRLSGNPLTCDCRLL 367

Query: 238 SLLVFWYRRHFSSVMD--------FKNDYTCRLWSDSRHSRQVLLLQDSFMNCSDSIING 289
            LL    RRH    M              + + +SD        +L      C  ++I  
Sbjct: 368 WLLRL--RRHLDFGMSPPACAGPHHVQGKSLKEFSD--------ILPPGHFTCKPALIRK 417

Query: 290 SFRALGFIHEAQVGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLV 349
           S         A+ G   +  C S  G+      W+ P    L     +    V  +G+L 
Sbjct: 418 SGPRWVI---AEEGGHAVFSC-SGDGDPAPTVSWMRPHGAWLGRAGRVR---VLEDGTLE 470

Query: 350 IESPRFEDAGVYSCIAMN 367
           I S +  D G Y C+  N
Sbjct: 471 IRSVQLRDRGAYVCVVSN 488



 Score = 34.7 bits (78), Expect = 0.22
 Identities = 31/106 (29%), Positives = 50/106 (47%), Gaps = 4/106 (3%)

Query: 52  VSCTNKNLSKVPGN-LFRL--IKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSI 108
           ++ T  NLS VP   L+ L  ++ LDLS N I  + +  +     +L  L L    +TSI
Sbjct: 257 LAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLS-PLVRLQELRLSGACLTSI 315

Query: 109 STGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHIS 154
           +  +F        LD++ N L+T++   F     L  L L  N ++
Sbjct: 316 AAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLT 361



 Score = 34.7 bits (78), Expect = 0.22
 Identities = 27/84 (32%), Positives = 39/84 (46%)

Query: 95  LNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHIS 154
           L  L L  N I++I     S    L+ L LS   L ++    F  L    +L + +N + 
Sbjct: 278 LRVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQ 337

Query: 155 YLDPSAFGGLSQLQKLYLSGNFLT 178
            L+ +AF    +L  L LSGN LT
Sbjct: 338 TLEETAFPSPDKLVTLRLSGNPLT 361


>gi|40217825 slit and trk like 6 [Homo sapiens]
          Length = 841

 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 65/234 (27%), Positives = 108/234 (46%), Gaps = 34/234 (14%)

Query: 23  LLCLLMITVTVGPGASGVCPTACIC----ATDIVSCTNKNLSKV------PGNLFRLIKR 72
           L C+ + + T    + G C + C C     T +++C  K +  V      P   F+L   
Sbjct: 13  LACISLHSQTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQL--- 69

Query: 73  LDLSYNRIGLLDSEWIPVSFAKLNTLILRH---NNITSISTGSFSTTPNLKCLDLSSNKL 129
             L  N + +L +      F+ L   I  H   NNI  I  G+F+    LK L ++ N L
Sbjct: 70  -SLLNNGLTMLHTN----DFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSL 124

Query: 130 KTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRF 189
           + +K   F  L+ LE L   NN I+ ++PSAF  L++L+ L L+ N +   P ++    F
Sbjct: 125 EILKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNI----F 180

Query: 190 KLAELMFLDVSYNRIPSMP----MHHINLVPGKQLRGIYLHGNPFVCDCSLYSL 239
           +   L  LD+  N++ ++P    + HI      ++  + L  N + C+C L  L
Sbjct: 181 RFVPLTHLDLRGNQLQTLPYVGFLEHIG-----RILDLQLEDNKWACNCDLLQL 229



 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 38/111 (34%), Positives = 62/111 (55%), Gaps = 5/111 (4%)

Query: 118 NLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFL 177
           N + L L+ N + ++  +   E   LE+L L NN I  L+  +F  L++LQKLYL+GN L
Sbjct: 364 NPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHL 423

Query: 178 TQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQLRGIYLHGN 228
           T+    +++G   L  L +L + YN I  +     N +P  +L+ +YL+ N
Sbjct: 424 TKLSKGMFLG---LHNLEYLYLEYNAIKEILPGTFNPMP--KLKVLYLNNN 469



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 38/113 (33%), Positives = 57/113 (50%), Gaps = 2/113 (1%)

Query: 70  IKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKL 129
           ++ L L  NRI +L+ E   ++  +L  L L  N++T +S G F    NL+ L L  N +
Sbjct: 389 LEMLHLGNNRIEVLE-EGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAI 447

Query: 130 KTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPM 182
           K +    F  +  L+VL L NN +  L P  F G+  L K+ L  N  T  P+
Sbjct: 448 KEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGV-PLTKVNLKTNQFTHLPV 499



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 44/165 (26%), Positives = 68/165 (41%), Gaps = 27/165 (16%)

Query: 98  LILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLD 157
           LIL  N I S+          L+ L L +N+++ ++   F  L  L+ L L  NH++ L 
Sbjct: 368 LILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLS 427

Query: 158 PSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFK-LAELMFLDVSYNRIPSMPMHHINLVP 216
              F GL  L+ LYL  N +     ++  G F  + +L  L ++ N +  +P H  + VP
Sbjct: 428 KGMFLGLHNLEYLYLEYNAI----KEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVP 483

Query: 217 GKQ----------------------LRGIYLHGNPFVCDCSLYSL 239
             +                      L  I L  NP+ C C L  L
Sbjct: 484 LTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGL 528



 Score = 35.4 bits (80), Expect = 0.13
 Identities = 32/111 (28%), Positives = 53/111 (47%), Gaps = 2/111 (1%)

Query: 65  NLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDL 124
           NL RL ++L L+ N +  L S+ + +    L  L L +N I  I  G+F+  P LK L L
Sbjct: 409 NLTRL-QKLYLNGNHLTKL-SKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYL 466

Query: 125 SSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGN 175
           ++N L+ +   +F  + + +V L  N        +    L  L ++ L  N
Sbjct: 467 NNNLLQVLPPHIFSGVPLTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDN 517


>gi|40217820 slit and trk like 3 protein [Homo sapiens]
          Length = 977

 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 62/211 (29%), Positives = 99/211 (46%), Gaps = 26/211 (12%)

Query: 40  VCPTACICATDI------VSCTNKNLSKVPGNLFRLI--KRLDLSYNRIGLL--DSEWIP 89
           +CPT C C   I      V+C  +  + +   L R +  K+L LS N I  +     W  
Sbjct: 372 ICPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSDFW-- 429

Query: 90  VSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLY 149
            +F+ L+ L L +N I+ +  G+F   PNLK L L+ N ++ +   +F+ L+ L  L   
Sbjct: 430 -NFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFE 488

Query: 150 NNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMP- 208
            N I  + P+AF  +  L+ L+L+ N L   P D + G      L  L++  N    +P 
Sbjct: 489 FNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAG----TSLARLNLRKNYFLYLPV 544

Query: 209 ---MHHINLVPGKQLRGIYLHGNPFVCDCSL 236
              + H+N +       I L+ NP+ C C L
Sbjct: 545 AGVLEHLNAIV-----QIDLNENPWDCTCDL 570



 Score = 69.3 bits (168), Expect = 8e-12
 Identities = 54/173 (31%), Positives = 82/173 (47%), Gaps = 10/173 (5%)

Query: 91  SFAKLNTLI---LRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLL 147
           SF  LN  +   L +N +  I TG+F+    LK L L  NKL   +N  F  L+ LE L 
Sbjct: 96  SFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFRNDTFLGLESLEYLQ 155

Query: 148 LYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSM 207
              N I  ++  AF  LS+L+ L L+ N +   P +L    FK   L  LD+  NR+  +
Sbjct: 156 ADYNVIKRIESGAFRNLSKLRVLILNDNLIPMLPTNL----FKAVSLTHLDLRGNRLKVL 211

Query: 208 PMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLLVFWYRRHFSSVMDFKNDYTC 260
               +    G+ L  + L  NP+ C C +  L  +  R  +++++    D TC
Sbjct: 212 FYRGMLDHIGRSLMELQLEENPWNCTCEIVQLKSWLERIPYTALV---GDITC 261



 Score = 38.1 bits (87), Expect = 0.020
 Identities = 27/83 (32%), Positives = 38/83 (45%), Gaps = 3/83 (3%)

Query: 122 LDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFP 181
           L L  N ++ +    F  L     + L NN +  +   AF GL  L++LYL  N L  F 
Sbjct: 82  LYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFR 141

Query: 182 MDLYVGRFKLAELMFLDVSYNRI 204
            D ++G   L  L +L   YN I
Sbjct: 142 NDTFLG---LESLEYLQADYNVI 161


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.136    0.410 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,776,155
Number of Sequences: 37866
Number of extensions: 878395
Number of successful extensions: 4323
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 223
Number of HSP's successfully gapped in prelim test: 186
Number of HSP's that attempted gapping in prelim test: 2368
Number of HSP's gapped (non-prelim): 1349
length of query: 522
length of database: 18,247,518
effective HSP length: 107
effective length of query: 415
effective length of database: 14,195,856
effective search space: 5891280240
effective search space used: 5891280240
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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