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Search of human proteins with 21729876
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21729876 ATP-binding cassette, sub-family C, member 11
isoform b [Homo sapiens]
(1344 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21729876 ATP-binding cassette, sub-family C, member 11 isofor... 2654 0.0
gi|21729873 ATP-binding cassette, sub-family C, member 11 isofor... 2635 0.0
gi|15149474 ATP-binding cassette, sub-family C, member 11 isofor... 2635 0.0
gi|89111135 ATP-binding cassette protein C12 [Homo sapiens] 1203 0.0
gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform... 949 0.0
gi|157502201 ATP-binding cassette, sub-family C, member 4 isofor... 640 0.0
gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform ... 620 e-177
gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member... 591 e-168
gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor... 588 e-167
gi|134142335 ATP-binding cassette, sub-family C, member 1 isofor... 537 e-152
gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo ... 524 e-148
gi|190343023 ATP-binding cassette, sub-family C, member 6 isofor... 519 e-147
gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo ... 518 e-146
gi|239756495 PREDICTED: hypothetical protein [Homo sapiens] 518 e-146
gi|110832837 ATP-binding cassette, sub-family C, member 9 isofor... 510 e-144
gi|110832839 ATP-binding cassette, sub-family C, member 9 isofor... 502 e-141
gi|110832835 ATP-binding cassette, sub-family C, member 9 isofor... 500 e-141
gi|134142345 ATP-binding cassette, sub-family C, member 1 isofor... 470 e-132
gi|134142340 ATP-binding cassette, sub-family C, member 1 isofor... 423 e-118
gi|157502203 ATP-binding cassette, sub-family C, member 4 isofor... 391 e-108
gi|134142342 ATP-binding cassette, sub-family C, member 1 isofor... 347 6e-95
gi|90421313 cystic fibrosis transmembrane conductance regulator ... 250 6e-66
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 179 1e-44
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 167 5e-41
gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C... 114 6e-25
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A... 114 6e-25
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B... 111 5e-24
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo... 110 1e-23
gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo ... 105 3e-22
gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo s... 105 3e-22
>gi|21729876 ATP-binding cassette, sub-family C, member 11 isoform b
[Homo sapiens]
Length = 1344
Score = 2654 bits (6878), Expect = 0.0
Identities = 1344/1344 (100%), Positives = 1344/1344 (100%)
Query: 1 MTRKRTYWVPNSSGGLVNRGIDIGDDMVSGLIYKTYTLQDGPWSQQERNPEAPGRAAVPP 60
MTRKRTYWVPNSSGGLVNRGIDIGDDMVSGLIYKTYTLQDGPWSQQERNPEAPGRAAVPP
Sbjct: 1 MTRKRTYWVPNSSGGLVNRGIDIGDDMVSGLIYKTYTLQDGPWSQQERNPEAPGRAAVPP 60
Query: 61 WGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPL 120
WGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPL
Sbjct: 61 WGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPL 120
Query: 121 SVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLG 180
SVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLG
Sbjct: 121 SVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLG 180
Query: 181 PILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSS 240
PILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSS
Sbjct: 181 PILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSS 240
Query: 241 FAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIG 300
FAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIG
Sbjct: 241 FAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIG 300
Query: 301 YTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKP 360
YTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKP
Sbjct: 301 YTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKP 360
Query: 361 FAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSM 420
FAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSM
Sbjct: 361 FAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSM 420
Query: 421 LASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEAT 480
LASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEAT
Sbjct: 421 LASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEAT 480
Query: 481 LSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMML 540
LSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMML
Sbjct: 481 LSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMML 540
Query: 541 GVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDK 600
GVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDK
Sbjct: 541 GVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDK 600
Query: 601 ARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDP 660
ARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDP
Sbjct: 601 ARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDP 660
Query: 661 LSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELM 720
LSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELM
Sbjct: 661 LSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELM 720
Query: 721 QKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEESLNGNAVPEHQLTQE 780
QKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEESLNGNAVPEHQLTQE
Sbjct: 721 QKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEESLNGNAVPEHQLTQE 780
Query: 781 EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSS 840
EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSS
Sbjct: 781 EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSS 840
Query: 841 RESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLF 900
RESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLF
Sbjct: 841 RESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLF 900
Query: 901 NKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSP 960
NKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSP
Sbjct: 901 NKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSP 960
Query: 961 YILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTED 1020
YILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTED
Sbjct: 961 YILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTED 1020
Query: 1021 FISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMA 1080
FISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMA
Sbjct: 1021 FISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMA 1080
Query: 1081 VNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGE 1140
VNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGE
Sbjct: 1081 VNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGE 1140
Query: 1141 IIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRIL 1200
IIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRIL
Sbjct: 1141 IIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRIL 1200
Query: 1201 IDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAI 1260
IDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAI
Sbjct: 1201 IDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAI 1260
Query: 1261 ILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDR 1320
ILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDR
Sbjct: 1261 ILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDR 1320
Query: 1321 PEVLRKKPGSLFAALMATATSSLR 1344
PEVLRKKPGSLFAALMATATSSLR
Sbjct: 1321 PEVLRKKPGSLFAALMATATSSLR 1344
>gi|21729873 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 2635 bits (6829), Expect = 0.0
Identities = 1344/1382 (97%), Positives = 1344/1382 (97%), Gaps = 38/1382 (2%)
Query: 1 MTRKRTYWVPNSSGGLVNRGIDIGDDMVSGLIYKTYTLQDGPWSQQERNPEAPGRAAVPP 60
MTRKRTYWVPNSSGGLVNRGIDIGDDMVSGLIYKTYTLQDGPWSQQERNPEAPGRAAVPP
Sbjct: 1 MTRKRTYWVPNSSGGLVNRGIDIGDDMVSGLIYKTYTLQDGPWSQQERNPEAPGRAAVPP 60
Query: 61 WGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPL 120
WGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPL
Sbjct: 61 WGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPL 120
Query: 121 SVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLG 180
SVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLG
Sbjct: 121 SVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLG 180
Query: 181 PILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSS 240
PILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSS
Sbjct: 181 PILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSS 240
Query: 241 FAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIG 300
FAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIG
Sbjct: 241 FAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIG 300
Query: 301 YTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKP 360
YTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKP
Sbjct: 301 YTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKP 360
Query: 361 FAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSM 420
FAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSM
Sbjct: 361 FAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSM 420
Query: 421 LASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEAT 480
LASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEAT
Sbjct: 421 LASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEAT 480
Query: 481 LSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMML 540
LSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMML
Sbjct: 481 LSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMML 540
Query: 541 GVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDK 600
GVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDK
Sbjct: 541 GVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDK 600
Query: 601 ARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDP 660
ARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDP
Sbjct: 601 ARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDP 660
Query: 661 LSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELM 720
LSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELM
Sbjct: 661 LSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELM 720
Query: 721 QKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEESLNGNAVPEHQLTQE 780
QKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEESLNGNAVPEHQLTQE
Sbjct: 721 QKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEESLNGNAVPEHQLTQE 780
Query: 781 EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSS 840
EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSS
Sbjct: 781 EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSS 840
Query: 841 RESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLF 900
RESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLF
Sbjct: 841 RESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLF 900
Query: 901 NKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSP 960
NKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSP
Sbjct: 901 NKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSP 960
Query: 961 YILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTED 1020
YILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTED
Sbjct: 961 YILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTED 1020
Query: 1021 FISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMA 1080
FISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMA
Sbjct: 1021 FISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMA 1080
Query: 1081 VNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGE 1140
VNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGE
Sbjct: 1081 VNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGE 1140
Query: 1141 IIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRIL 1200
IIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRIL
Sbjct: 1141 IIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRIL 1200
Query: 1201 IDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKA- 1259
IDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKA
Sbjct: 1201 IDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAI 1260
Query: 1260 -------------------------------------IILIDEATASIDMETDTLIQRTI 1282
IILIDEATASIDMETDTLIQRTI
Sbjct: 1261 SKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTLIQRTI 1320
Query: 1283 REAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATATSS 1342
REAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATATSS
Sbjct: 1321 REAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATATSS 1380
Query: 1343 LR 1344
LR
Sbjct: 1381 LR 1382
>gi|15149474 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 2635 bits (6829), Expect = 0.0
Identities = 1344/1382 (97%), Positives = 1344/1382 (97%), Gaps = 38/1382 (2%)
Query: 1 MTRKRTYWVPNSSGGLVNRGIDIGDDMVSGLIYKTYTLQDGPWSQQERNPEAPGRAAVPP 60
MTRKRTYWVPNSSGGLVNRGIDIGDDMVSGLIYKTYTLQDGPWSQQERNPEAPGRAAVPP
Sbjct: 1 MTRKRTYWVPNSSGGLVNRGIDIGDDMVSGLIYKTYTLQDGPWSQQERNPEAPGRAAVPP 60
Query: 61 WGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPL 120
WGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPL
Sbjct: 61 WGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPL 120
Query: 121 SVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLG 180
SVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLG
Sbjct: 121 SVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLG 180
Query: 181 PILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSS 240
PILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSS
Sbjct: 181 PILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSS 240
Query: 241 FAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIG 300
FAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIG
Sbjct: 241 FAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIG 300
Query: 301 YTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKP 360
YTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKP
Sbjct: 301 YTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKP 360
Query: 361 FAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSM 420
FAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSM
Sbjct: 361 FAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSM 420
Query: 421 LASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEAT 480
LASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEAT
Sbjct: 421 LASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEAT 480
Query: 481 LSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMML 540
LSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMML
Sbjct: 481 LSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMML 540
Query: 541 GVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDK 600
GVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDK
Sbjct: 541 GVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDK 600
Query: 601 ARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDP 660
ARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDP
Sbjct: 601 ARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDP 660
Query: 661 LSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELM 720
LSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELM
Sbjct: 661 LSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELM 720
Query: 721 QKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEESLNGNAVPEHQLTQE 780
QKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEESLNGNAVPEHQLTQE
Sbjct: 721 QKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEESLNGNAVPEHQLTQE 780
Query: 781 EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSS 840
EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSS
Sbjct: 781 EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSS 840
Query: 841 RESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLF 900
RESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLF
Sbjct: 841 RESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLF 900
Query: 901 NKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSP 960
NKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSP
Sbjct: 901 NKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSP 960
Query: 961 YILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTED 1020
YILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTED
Sbjct: 961 YILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTED 1020
Query: 1021 FISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMA 1080
FISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMA
Sbjct: 1021 FISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMA 1080
Query: 1081 VNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGE 1140
VNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGE
Sbjct: 1081 VNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGE 1140
Query: 1141 IIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRIL 1200
IIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRIL
Sbjct: 1141 IIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRIL 1200
Query: 1201 IDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKA- 1259
IDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKA
Sbjct: 1201 IDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAI 1260
Query: 1260 -------------------------------------IILIDEATASIDMETDTLIQRTI 1282
IILIDEATASIDMETDTLIQRTI
Sbjct: 1261 SKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTLIQRTI 1320
Query: 1283 REAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATATSS 1342
REAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATATSS
Sbjct: 1321 REAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATATSS 1380
Query: 1343 LR 1344
LR
Sbjct: 1381 LR 1382
>gi|89111135 ATP-binding cassette protein C12 [Homo sapiens]
Length = 1359
Score = 1203 bits (3112), Expect = 0.0
Identities = 622/1342 (46%), Positives = 862/1342 (64%), Gaps = 78/1342 (5%)
Query: 63 KYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSV 122
+YD +L+TMIP RP R AP P+D+AGL S+ T SWLTP+M++ R RL +T+PPLS
Sbjct: 24 RYDPSLKTMIPVRPCARL-APNPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLST 82
Query: 123 HDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLGPI 182
+D+SD N +R LW+EEV+R G EKAS+ V+ +FQRTR++ D + I I + +GP+
Sbjct: 83 YDSSDTNAKRFRVLWDEEVARVGPEKASLSHVVWKFQRTRVLMDIVANILCIIMAAIGPV 142
Query: 183 LIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSSFA 242
++I +IL+ +E G V G+GLC ALF +E K ++ +W IN RTAIR + A+S+
Sbjct: 143 ILIHQILQQTERTSGKVWVGIGLCIALFATEFTKVFFWALAWAINYRTAIRLKVALSTLV 202
Query: 243 FEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIGYT 302
FE L+ FK++ HI+ GE ++ + D LFE + PL +V C+ ++FI+G T
Sbjct: 203 FENLVSFKTLTHISVGEVLNILSSDSYSLFEAALFCPLPATIPILMVFCAAYAFFILGPT 262
Query: 303 AFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFA 362
A I I Y++ P+ +FM ++ + V+D+R++ +E LTCI+LIKMY WEK F
Sbjct: 263 ALIGISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAWEKSFT 322
Query: 363 KIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLA 422
I+D+RR+ERKLLEK G VQS S I+ T+A + + H L+ KLTA +AFS++A
Sbjct: 323 NTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTLSCHILLRRKLTAPVAFSVIA 382
Query: 423 SLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEATLS 482
N+++ S+ +P ++K + + ++ R KK + +SP Y+ +DP L+ ATL+
Sbjct: 383 MFNVMKFSIAILPFSIKAMAEANVSLRRMKKILIDKSPPSYITQPEDPDTVLLLANATLT 442
Query: 483 WQ------QTCPGIVNGALEL---ERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLV 533
W+ T + N L +R+ SE + A GPEE+ +SL LH I+ V
Sbjct: 443 WEHEASRKSTPKKLQNQKRHLCKKQRSEAYSERSPPAKGATGPEEQSDSLKSVLHSISFV 502
Query: 534 VSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENIL 593
V KG +LG+CGN GSGKSSLL+A+L +M L +G V V G+LAYV QQAWI GN+RENIL
Sbjct: 503 VRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGTLAYVSQQAWIFHGNVRENIL 562
Query: 594 MGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQ 653
G YD RY + C L +DL LP+GD+TEIGERGLNLSGGQ+QRISLARAVYSDRQ
Sbjct: 563 FGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERGLNLSGGQRQRISLARAVYSDRQ 622
Query: 654 IYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICEN 713
+YLLDDPLSAVDAHVGKH+FEECIKKTLRGKTVVLVTHQLQ+LE C ++ILLE+G+ICE
Sbjct: 623 LYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTHQLQFLESCDEVILLEDGEICEK 682
Query: 714 GTHSELMQKKGKYAQLIQKMH-------------------KEATSDMLQDTAKIAEKPKV 754
GTH ELM+++G+YA+LI + KE+ ++ +D I P
Sbjct: 683 GTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNAAMVEAFKESPAEREEDAGIIVLAPGN 742
Query: 755 E-SQALATSLEESLNGNAVPEHQLTQEEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFV 813
E + + VPEHQL Q E +EG+++W+ YH YI+A+GGY++S F
Sbjct: 743 EKDEGKESETGSEFVDTKVPEHQLIQTESPQEGTVTWKTYHTYIKASGGYLLSLFTVFLF 802
Query: 814 VLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLL 873
+L++ FS WWL WL++GS + N TM ++G + + YQ VY + + +
Sbjct: 803 LLMIGSAAFSNWWLGLWLDKGSRMTCGPQGNRTMCEVGAVLADIGQHVYQWVYTASMVFM 862
Query: 874 ICVGVCSSGIFTKVTRKASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQL 933
+ GV +FTK T AS++LH+ +F+K+ + PMSFFDT P GRL+N F+ D+++LD
Sbjct: 863 LVFGVTKGFVFTKTTLMASSSLHDTVFDKILKSPMSFFDTTPTGRLMNRFSKDMDELDVR 922
Query: 934 LPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENY 993
LP +E FL MV+ +L+I++ + P +LL+ A + V FI +F + + K++EN
Sbjct: 923 LPFHAENFLQQFFMVVFILVILAAVFPAVLLVVASLAVGFFILLRIFHRGVQELKKVENV 982
Query: 994 SRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIM 1053
SRSP F+HI +S+QGL IH YGK E I+ +LL F + RW ALR++++
Sbjct: 983 SRSPWFTHITSSMQGLGIIHAYGKKESCITY----------HLLYFNCALRWFALRMDVL 1032
Query: 1054 TNLVTLAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQ 1113
N++T VAL V SS S K ++++ ++QL+ Q R G ET+A+FT+VE + +
Sbjct: 1033 MNILTFTVALLVTLSFSSISTSSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLRE 1092
Query: 1114 YMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGI 1173
Y+ CV E ++ +CP+ WP GEI F+DY M+YRDNTP VL +NL I+ + VGI
Sbjct: 1093 YISTCVPECTHPLKVGTCPKDWPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGI 1152
Query: 1174 VGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIR 1233
VGRTGSGKSSLGMALFRLVEP +G I ID VDIC + LEDLR+KL+VIPQDPVL GT+R
Sbjct: 1153 VGRTGSGKSSLGMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVR 1212
Query: 1234 FNLDPFDRHTDQQIWDALERTFL------------------------------------- 1256
+NLDPF+ HTD+ +W LERTF+
Sbjct: 1213 YNLDPFESHTDEMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALL 1272
Query: 1257 -TKAIILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKV 1315
IIL+DEATAS+D +TDTL+Q TI++AF+GCTVL IAHR+ TVLNCDH+LVM NGKV
Sbjct: 1273 RNSKIILLDEATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKV 1332
Query: 1316 VEFDRPEVLRKKPGSLFAALMA 1337
+EFD+PEVL +KP S FA L+A
Sbjct: 1333 IEFDKPEVLAEKPDSAFAMLLA 1354
>gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform 1
[Homo sapiens]
Length = 1437
Score = 949 bits (2453), Expect = 0.0
Identities = 528/1360 (38%), Positives = 785/1360 (57%), Gaps = 79/1360 (5%)
Query: 60 PWGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLM-IQSLRSRLDENTIP 118
P GKY L + P R + P+DNAGLFS +T SWL+ L + + L +
Sbjct: 77 PKGKYHHGLSALKPIRTTSKHQ--HPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVW 134
Query: 119 PLSVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASV 178
LS H++SD N +RL RLW+EE++ G + AS+ V+ F RTRLI + + +A
Sbjct: 135 SLSKHESSDVNCRRLERLWQEELNEVGPDAASLRRVVWIFCRTRLILSIVCLMITQLAGF 194
Query: 179 LGPILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAV 238
GP ++ +LEY++ N+ + + L L L+E V+S S + +W +N RT +R R A+
Sbjct: 195 SGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTWALNYRTGVRLRGAI 254
Query: 239 SSFAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFI 298
+ AF+K+++ K++ + GE I+ + D +FE G L+ ++ I + I
Sbjct: 255 LTMAFKKILKLKNIKEKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVII 314
Query: 299 IGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWE 358
+G T F+ ++L +P +F +R+ + +D+R++ +EVLT IK IKMY W
Sbjct: 315 LGPTGFLGSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWV 374
Query: 359 KPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAF 418
K F++ ++ +R +ER++LEK G QS+T I+ +A+ V +H +L LTA+ AF
Sbjct: 375 KAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAF 434
Query: 419 SMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEE 478
+++ N + ++ P +VK L+ + AV RFK FL E P + +
Sbjct: 435 TVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKN 494
Query: 479 ATLSWQQTCPGIVNGAL---ELERNGHASEGMTRP--------RDALGPEEEGNSL---- 523
ATL+W + I N +++++ AS G A+ E++G+ L
Sbjct: 495 ATLAWDSSHSSIQNSPKLTPKMKKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHLLLDSD 554
Query: 524 ---GPE-----------------LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHL 563
PE LH I+L + +G ++G+CG+ GSGK+SL+SAIL +M L
Sbjct: 555 ERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTL 614
Query: 564 LEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGD 623
LEGS+ + G+ AYV QQAWI++ +R+NIL G YD+ RY VL+ C L DL +LP D
Sbjct: 615 LEGSIAISGTFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSD 674
Query: 624 MTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRG 683
+TEIGERG NLSGGQ+QRISLARA+YSDR IY+LDDPLSA+DAHVG HIF I+K L+
Sbjct: 675 LTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKS 734
Query: 684 KTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQ 743
KTV+ VTHQLQYL C ++I ++ G I E GTH ELM G YA + + T +
Sbjct: 735 KTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGETPPVEI 794
Query: 744 DTAKIAEKPKVESQALATSLEESLNGNAVP--EHQLTQEEEMEEGSLSWRVYHHYIQAAG 801
++ K + +SQ AV E QL Q EE +GS+ W VY YIQAAG
Sbjct: 795 NSKKETSGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQGSVPWSVYGVYIQAAG 854
Query: 802 GYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSF 861
G + +I +L V T FS WWLSYW++QGSG + N T ++ DNP + +
Sbjct: 855 GPLAFLVIMALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETSVS-DSMKDNPHMQY 913
Query: 862 YQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLFNKVFRCPMSFFDTIPIGRLLN 921
Y +Y L+ +++ + +F K T +AS+ LH++LF ++ R PM FFDT P GR+LN
Sbjct: 914 YASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILN 973
Query: 922 CFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFK 981
F+ D++++D LP +E F+ ++V + +++ + P+ L+ ++++ + +++ +
Sbjct: 974 RFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSR 1033
Query: 982 KAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLS 1041
I KRL+N ++SP SHI +S+QGL++IH Y K ++F+ +++ L D LF
Sbjct: 1034 VLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTC 1093
Query: 1042 STRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLET 1101
+ RW+A+RL++++ + L + P ++ +A++ +QL FQ T R+ ET
Sbjct: 1094 AMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLASET 1153
Query: 1102 EAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGI 1161
EA+FT+VERI Y+K EAP ++ + WPQ GE+ F++ M+YR+N P VL +
Sbjct: 1154 EARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVLKKV 1213
Query: 1162 NLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVI 1221
+ TI+ E +GIVGRTGSGKSSLGMALFRLVE G I IDGV I IGL DLRSKLS+I
Sbjct: 1214 SFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSII 1273
Query: 1222 PQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKA---------------------- 1259
PQ+PVL SGT+R NLDPF+++T+ QIWDALERT + +
Sbjct: 1274 PQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVG 1333
Query: 1260 ----------------IILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLN 1303
I+++DEATA++D ETD LIQ TIREAF CT+L IAHR+ TVL
Sbjct: 1334 ERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLG 1393
Query: 1304 CDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATATSSL 1343
D I+V+ G+VVEFD P VL S F A+ A A + +
Sbjct: 1394 SDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAAAENKV 1433
>gi|157502201 ATP-binding cassette, sub-family C, member 4 isoform 1
[Homo sapiens]
Length = 1325
Score = 640 bits (1651), Expect = 0.0
Identities = 433/1317 (32%), Positives = 669/1317 (50%), Gaps = 124/1317 (9%)
Query: 83 PQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEEVS 142
P PL +A L S + WL PL + RL+E+ + + D S + L W++EV
Sbjct: 10 PNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVL 69
Query: 143 R--RGIEKASVLLVMLR-FQRTRLIFDALLGICFCI---ASVLGPILIIPKILEYSE--E 194
R +K S+ +++ + ++ L+ LGI I A V+ PI + KI+ Y E +
Sbjct: 70 RAENDAQKPSLTRAIIKCYWKSYLV----LGIFTLIEESAKVIQPIFL-GKIINYFENYD 124
Query: 195 QLGNVVHGVGLCFALFLSECVKSLSFSSSWIIN--QRTAIRFRAAVSSFAFEKLIQFKSV 252
+ +V +A L+ C L+ Q +R R A+ + K ++ ++
Sbjct: 125 PMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNM 184
Query: 253 I--HITSGEAISFFTGDVNYLFEGVCY------GPLVLITCASLVICSISSYFIIGYTAF 304
T+G+ ++ + DVN + + GPL I +L+ + IG +
Sbjct: 185 AMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALL------WMEIGISCL 238
Query: 305 IAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKI 364
+ +++ PL ++ + T+ +D RIR +EV+T I++IKMY WEK F+ +
Sbjct: 239 AGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNL 298
Query: 365 IEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLASL 424
I +LR+KE + + ++ + + F + V + L +TAS F +
Sbjct: 299 ITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLY 358
Query: 425 NLLRLSV-FFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVF-EEATLS 482
+RL+V F P A++ ++ + ++ R + F L + + L K +V ++ T
Sbjct: 359 GAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAF 418
Query: 483 WQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLGV 542
W + ASE P L ++ V G +L V
Sbjct: 419 WDK-----------------ASET------------------PTLQGLSFTVRPGELLAV 443
Query: 543 CGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKAR 602
G G+GKSSLLSA+L E+ G V V G +AYV QQ W+ SG +R NIL G Y+K R
Sbjct: 444 VGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKER 503
Query: 603 YLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLS 662
Y +V+ C+L +DL+LL GD+T IG+RG LSGGQK R++LARAVY D IYLLDDPLS
Sbjct: 504 YEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLS 563
Query: 663 AVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQK 722
AVDA V +H+FE CI + L K +LVTHQLQYL+ QI++L++GK+ + GT++E ++
Sbjct: 564 AVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKS 623
Query: 723 KGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALA-TSLEESLNGNAVPEHQLTQ-- 779
+ L++K ++E+ + T + + ES + S SL A+ E Q T+
Sbjct: 624 GIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGAL-ESQDTENV 682
Query: 780 -----EEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQG 834
EE EG + ++ Y +Y +A ++V + + WWLSYW
Sbjct: 683 PVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYW---- 738
Query: 835 SGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTA 894
N N T+ GN+ + L++Y +Y + + G+ S + V +S
Sbjct: 739 --ANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQT 796
Query: 895 LHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLI 954
LHNK+F + + P+ FFD PIGR+LN F+ D+ LD LLP+ F+ L V+ V+ +
Sbjct: 797 LHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSV 856
Query: 955 VSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHV 1014
+ P+I + + +I F + KRLE+ +RSP+FSH+ +SLQGL +I
Sbjct: 857 AVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRA 916
Query: 1015 YGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPY 1074
Y E F D + LFL+++RW A+RL+ + + + VA F + ++ T
Sbjct: 917 YKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVA-FGSLILAKTLD 975
Query: 1075 SFKV-MAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQ 1133
+ +V +A++ L L FQ R E E +VER+++Y + EAP + P
Sbjct: 976 AGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDL-EKEAPWEYQKRP-PP 1033
Query: 1134 GWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVE 1193
WP G IIF + + Y P VL + I+ E VGIVGRTG+GKSSL ALFRL E
Sbjct: 1034 AWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSE 1093
Query: 1194 PMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALE- 1252
P G+I ID + IGL DLR K+S+IPQ+PVL +GT+R NLDPF+ HTD+++W+AL+
Sbjct: 1094 P-EGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQE 1152
Query: 1253 ------------------------------------RTFLTK-AIILIDEATASIDMETD 1275
R L K I++IDEATA++D TD
Sbjct: 1153 VQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTD 1212
Query: 1276 TLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLF 1332
LIQ+ IRE F CTVL IAHR+ T+++ D I+V+ +G++ E+D P VL + SLF
Sbjct: 1213 ELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLF 1269
Score = 85.9 bits (211), Expect = 2e-16
Identities = 65/238 (27%), Positives = 119/238 (50%), Gaps = 23/238 (9%)
Query: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMH---------LLEGSVGVQG---SL 574
L + ++ +G+ G TG+GKSSL+SA+ +L +G+ +
Sbjct: 1058 LKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKM 1117
Query: 575 AYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNL 634
+ +PQ+ + +G +R+N+ + L L +E LP TE+ E G N
Sbjct: 1118 SIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNF 1177
Query: 635 SGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGK----TVVLVT 690
S GQ+Q + LARA+ QI ++D+ + VD +E I+K +R K TV+ +
Sbjct: 1178 SVGQRQLVCLARAILRKNQILIIDEATANVDPRT-----DELIQKKIREKFAHCTVLTIA 1232
Query: 691 HQLQYLEFCGQIILLENGKICENGTHSELMQ-KKGKYAQLIQKMHKEATSDMLQDTAK 747
H+L + +I++L++G++ E L+Q K+ + +++Q++ K A + L +TAK
Sbjct: 1233 HRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQQLGK-AEAAALTETAK 1289
>gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform 1
[Homo sapiens]
Length = 1527
Score = 620 bits (1599), Expect = e-177
Identities = 442/1381 (32%), Positives = 657/1381 (47%), Gaps = 196/1381 (14%)
Query: 74 FRPKPRF-------PAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDAS 126
FR KP F P P P +AG S L W T + I R L+E + L D S
Sbjct: 190 FREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRS 249
Query: 127 DKNVQRLHRLWEEEVSRRGIEKAS------------VLLVMLRFQRTRLIFDALLGICFC 174
VQ+L W ++ + KAS VLL R ALL
Sbjct: 250 QMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGS 309
Query: 175 IASVLGPILIIPKILEYSEEQLGNVV------------HGVGLCFALFLSECVKSLSFSS 222
+ +I +L + QL +++ G + +FL ++SL
Sbjct: 310 SFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQH 369
Query: 223 SWIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPL 280
+ T ++FR + + K + + + S GE ++ + D + + L
Sbjct: 370 YYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPF--L 427
Query: 281 VLITCASLVICSISSYFI---IGYTAFIAILCYLLVFPL----AVFMTRMAVKAQHHTSE 333
L+ A L I ++ YF+ +G + + +L+ PL AV M VK +
Sbjct: 428 NLLWSAPLQII-LAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQM----K 482
Query: 334 VSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFII 393
+ D RI++ SE+L IK++K+Y WE F K +E +R+ E +LL + + T+ T
Sbjct: 483 LKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCS 542
Query: 394 PTVATAV--WVLIHTSLKLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRF 451
P + T + WV ++ L A AF ++ N+LRL + +P + LT + ++ R
Sbjct: 543 PFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRI 602
Query: 452 KKFFLQES--PVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTR 509
++F QE P + P A+ T +W Q P
Sbjct: 603 QQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLP--------------------- 641
Query: 510 PRDALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVG 569
P LH +++ V KG ++ V G G GKSSL+SA+L EM LEG V
Sbjct: 642 ---------------PTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVH 686
Query: 570 VQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGE 629
++GS+AYVPQQAWI + ++EN+L G A + RY Q L C+L DLE+LP GD TEIGE
Sbjct: 687 MKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGE 746
Query: 630 RGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECI--KKTLRGKTVV 687
+G+NLSGGQ+QR+SLARAVYSD I+LLDDPLSAVD+HV KHIF+ I + L GKT V
Sbjct: 747 KGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRV 806
Query: 688 LVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDT-- 745
LVTH + +L II+L +G++ E G + L+Q+ G +A + + L+D+
Sbjct: 807 LVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWT 866
Query: 746 ----AKIAEKPKVES------------------------QALATSLEESLNGNAVPEHQL 777
A+ E +E Q A S + G VP L
Sbjct: 867 ALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHL 926
Query: 778 -----------------TQEEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLT 820
TQEE+ G++ V+ Y +A G I +V
Sbjct: 927 GPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLAICLLYVGQSA-AA 985
Query: 821 IFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALL--LICVGV 878
I + WLS W +N MAD + +L Y + L L L + +
Sbjct: 986 IGANVWLSAW------------TNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAM 1033
Query: 879 CSSGIFTKVTRKASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFS 938
+ GI +A+ LH L + R P SFFDT P GR+LNCF+ D+ +D++L
Sbjct: 1034 AAGGI------QAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVI 1087
Query: 939 EQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPL 998
L I+ L+++ +P ++ + V+ + + KRLE+ SRSP+
Sbjct: 1088 LMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPI 1147
Query: 999 FSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVT 1058
+SH ++ G S I Y ++ DF DA ++ S RW+++ +E + N V
Sbjct: 1148 YSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVV 1207
Query: 1059 LAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMC 1118
L ALF G SS ++V+ LQ+ + R+ + E+ AVER+ +Y K
Sbjct: 1208 LFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKT- 1266
Query: 1119 VSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTG 1178
+EAP +EG+ P+GWP GE+ F++Y ++YR VL ++L + G E VGIVGRTG
Sbjct: 1267 ETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTG 1326
Query: 1179 SGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDP 1238
+GKSS+ + LFR++E G I IDG+++ IGL DLRS+L++IPQDP+L SGT+R NLDP
Sbjct: 1327 AGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDP 1386
Query: 1239 FDRHTDQQIWDALE-------------------------------------RTFLTKA-I 1260
F ++++ IW ALE R L K+ I
Sbjct: 1387 FGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRI 1446
Query: 1261 ILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDR 1320
+++DEATA+ID+ETD LIQ TIR F CTVL IAHR+ T+++ +LV+ G V EFD
Sbjct: 1447 LVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDS 1506
Query: 1321 P 1321
P
Sbjct: 1507 P 1507
Score = 80.9 bits (198), Expect = 8e-15
Identities = 54/211 (25%), Positives = 100/211 (47%), Gaps = 14/211 (6%)
Query: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
L ++L V G +G+ G TG+GKSS+ + + +G + + G
Sbjct: 1306 LRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQ 1365
Query: 574 LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLN 633
L +PQ + SG +R N+ G+Y + L L+ + P G + E G N
Sbjct: 1366 LTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGEN 1425
Query: 634 LSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQL 693
LS GQ+Q + LARA+ +I +LD+ +A+D ++ + I+ TV+ + H+L
Sbjct: 1426 LSVGQRQLVCLARALLRKSRILVLDEATAAIDLET-DNLIQATIRTQFDTCTVLTIAHRL 1484
Query: 694 QYLEFCGQIILLENGKICENGTHSELMQKKG 724
+ ++++L+ G + E + + L+ +G
Sbjct: 1485 NTIMDYTRVLVLDKGVVAEFDSPANLIAARG 1515
>gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
[Homo sapiens]
Length = 1545
Score = 591 bits (1524), Expect = e-168
Identities = 390/1229 (31%), Positives = 625/1229 (50%), Gaps = 171/1229 (13%)
Query: 209 LFLSECVKSLSFSSSWIINQRTAIRFRAAVSSFAFEKLIQFKSVIH--ITSGEAISFFTG 266
LF + ++S + + + ++ R A+ + ++K + ++ T GE ++ +
Sbjct: 367 LFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLMSV 426
Query: 267 DVNYLFEGVCYGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVK 326
D L + + ++ + +V+ + +G + + +LV P+ ++ +
Sbjct: 427 DAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKT 486
Query: 327 AQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLT 386
Q + D+R+++ +E+L+ IK++K + WE F +++LR+KE K L +Q +
Sbjct: 487 IQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVV 546
Query: 387 ----SITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLT 442
+T ++ V +V+VL+ ++ L A AF+ + N+LR + +P+ + +
Sbjct: 547 IFVFQLTPVLVSVVTFSVYVLVDSNNILD--AQKAFTSITLFNILRFPLSMLPMMISSML 604
Query: 443 NSKSAVMRFKKFF----LQESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALELE 498
+ + R +K+ L S + + KA+ F EA+ +W+
Sbjct: 605 QASVSTERLEKYLGGDDLDTSAIRHDCNFD---KAMQFSEASFTWE-------------- 647
Query: 499 RNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAIL 558
H SE R +NL + G ++ V G GSGKSSL+SA+L
Sbjct: 648 ---HDSEATVRD-------------------VNLDIMAGQLVAVIGPVGSGKSSLISAML 685
Query: 559 EEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLEL 618
EM + G + ++G+ AYVPQQ+WI +G I++NIL G +++ RY QVL C+L DLE+
Sbjct: 686 GEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLPDLEM 745
Query: 619 LPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIK 678
LP GD+ EIGE+G+NLSGGQKQRISLARA Y + IYLLDDPLSAVDAHVGKHIF + +
Sbjct: 746 LPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLG 805
Query: 679 KT--LRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKM--- 733
L+GKT +LVTH + +L +I++L NG I E G++S L+ KKG++A+ ++
Sbjct: 806 PNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKTFLRH 865
Query: 734 ---HKEAT------------------SDMLQDTAKIAEKPKVESQALAT----------- 761
+EAT ++ +D A I + + + +
Sbjct: 866 TGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAASITMRRENSFRRTLSRSSRSNGRHLK 925
Query: 762 SLEESL---NGNAVPEHQ-------LTQEEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFF 811
SL SL N N++ E + L ++E +E G + + +Y Y+QA G + + II
Sbjct: 926 SLRNSLKTRNVNSLKEDEELVKGQKLIKKEFIETGKVKFSIYLEYLQAIGLFSIFFIILA 985
Query: 812 FVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNP--QLSFYQLVYGLN 869
FV+ V I S WLS W T+ S+ N T D P Q VYG
Sbjct: 986 FVMNSVAF-IGSNLWLSAW------TSDSKIFNST--------DYPASQRDMRVGVYGAL 1030
Query: 870 ALLLICVGVCSSGIFTKVTR--------KASTALHNKLFNKVFRCPMSFFDTIPIGRLLN 921
L + GIF + AS LH +L N + R PM FFDT P GR++N
Sbjct: 1031 GL--------AQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIVN 1082
Query: 922 CFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFK 981
FAGD+ +D LP ++ L +I+ L+++ + +P ++ + +I M +
Sbjct: 1083 RFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFYV 1142
Query: 982 KAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLS 1041
+RL++ +RSP++SH ++ GL I + + F+ + D + +++
Sbjct: 1143 STSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWIT 1202
Query: 1042 STRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLET 1101
S RW+A+RLE++ NL AL + + ++ L + + R+ E
Sbjct: 1203 SNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMTSEI 1262
Query: 1102 EAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGI 1161
E AVERI +Y K+ +EAP + P WP G+I F +Y ++YR VL GI
Sbjct: 1263 ETNIVAVERITEYTKV-ENEAPWVTDKRP-PPDWPSKGKIQFNNYQVRYRPELDLVLRGI 1320
Query: 1162 NLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVI 1221
I E +G+VGRTG+GKSSL LFR++E G+I+IDGVDI SIGL DLR KL++I
Sbjct: 1321 TCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTII 1380
Query: 1222 PQDPVLLSGTIRFNLDPFDRHTDQQIWDALE----------------------------- 1252
PQDP+L SG++R NLDPF+ ++D++IW ALE
Sbjct: 1381 PQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIG 1440
Query: 1253 --------RTFLTKA-IILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLN 1303
R L K+ I+++DEATA++D+ETD LIQ TI+ F CTV+ IAHR+ T+++
Sbjct: 1441 QRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMD 1500
Query: 1304 CDHILVMGNGKVVEFDRPEVLRKKPGSLF 1332
D ++V+ NGK++E PE L + PG +
Sbjct: 1501 SDKVMVLDNGKIIECGSPEELLQIPGPFY 1529
>gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1
[Homo sapiens]
Length = 1531
Score = 588 bits (1516), Expect = e-167
Identities = 404/1376 (29%), Positives = 668/1376 (48%), Gaps = 180/1376 (13%)
Query: 81 PAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEE 140
P P P +A S +T W+T L+++ R L+ + + L+ D S++ V L + W++E
Sbjct: 205 PNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKE 264
Query: 141 VSRRGIEKASVL-----------------------LVMLRFQR--TRLIFDAL---LGIC 172
++ + V+ L++ Q+ +F L G
Sbjct: 265 CAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPY 324
Query: 173 FCIASVLGPI---------LIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSS 223
F ++ I I+ ++++ + G LF++ C+++L
Sbjct: 325 FLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQY 384
Query: 224 WIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPLV 281
+ I + +R + AV + K + + +S GE ++ + D + Y ++
Sbjct: 385 FHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMI 444
Query: 282 LITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRV 341
+++ + +G + + +L+ P+ M Q + D RI++
Sbjct: 445 WSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKL 504
Query: 342 TSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVW 401
+E+L IK++K+Y WE F + +R++E K+L+K + ++ + T P +
Sbjct: 505 MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCT 564
Query: 402 VLIHTSLKLK--LTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQES 459
++ ++ L A AF LA N+LR + +P+ + + + ++ R + F E
Sbjct: 565 FAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEE 624
Query: 460 ---PVFYVQTLQDP--SKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRDAL 514
+ ++D + ++ AT +W ++ P +NG
Sbjct: 625 LEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNG--------------------- 663
Query: 515 GPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSL 574
I + +G ++ V G G GKSSLLSA+L EM +EG V ++GS+
Sbjct: 664 ---------------ITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSV 708
Query: 575 AYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNL 634
AYVPQQAWI + ++RENIL G ++ Y V+ C+L DLE+LP GD TEIGE+G+NL
Sbjct: 709 AYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNL 768
Query: 635 SGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECI--KKTLRGKTVVLVTHQ 692
SGGQKQR+SLARAVYS+ IYL DDPLSAVDAHVGKHIFE I K L+ KT +LVTH
Sbjct: 769 SGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHS 828
Query: 693 LQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAKIA--- 749
+ YL II++ GKI E G++ EL+ + G +A+ ++ A+++ QD +
Sbjct: 829 MSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTY---ASTEQEQDAEENGVTG 885
Query: 750 ------EKPKVESQALAT-----------SLEESLNGNAVPEHQLTQE------------ 780
E ++E+ L T S S +G+ H T E
Sbjct: 886 VSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETW 945
Query: 781 -----EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGS 835
++ + G + VY Y++A G ++ IF F+ V + S +WLS W +
Sbjct: 946 KLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHV-SALASNYWLSLWTDDPI 1004
Query: 836 GTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTAL 895
+ + ++ G + + ++ V+G + + V GI AS L
Sbjct: 1005 VNGTQEHTKVRLSVYGALGISQGIA----VFGYS------MAVSIGGIL------ASRCL 1048
Query: 896 HNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIV 955
H L + + R PMSFF+ P G L+N F+ +L+ +D ++P + F+ VI +++
Sbjct: 1049 HVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVI 1108
Query: 956 SVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVY 1015
+ +P ++ + +I F + + KRLE+ SRSP++SH +L G+S I +
Sbjct: 1109 LLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAF 1168
Query: 1016 GKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYS 1075
+ E FI Q D + + RW+A+RLE + N + L ALF S
Sbjct: 1169 EEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAG 1228
Query: 1076 FKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGW 1135
++V+ LQ+ + R+ E E AVER+ +Y + EAP ++ T+ P W
Sbjct: 1229 LVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSE-TEKEAPWQIQETAPPSSW 1287
Query: 1136 PQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPM 1195
PQ G + F++Y ++YR++ VL IN+TI G E VGIVGRTG+GKSSL + LFR+ E
Sbjct: 1288 PQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESA 1347
Query: 1196 AGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALE--- 1252
G I+IDG++I IGL DLR K+++IPQDPVL SG++R NLDPF +++D+++W +LE
Sbjct: 1348 EGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAH 1407
Query: 1253 ----------------------------------RTFLTKA-IILIDEATASIDMETDTL 1277
R L K I+++DEATA++D+ETD L
Sbjct: 1408 LKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDL 1467
Query: 1278 IQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFA 1333
IQ TIR F+ CTVL IAHR+ T+++ ++V+ G++ E+ P L ++ G ++
Sbjct: 1468 IQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYS 1523
Score = 90.9 bits (224), Expect = 7e-18
Identities = 65/224 (29%), Positives = 105/224 (46%), Gaps = 18/224 (8%)
Query: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
L IN+ ++ G +G+ G TG+GKSSL + EG + + G
Sbjct: 1310 LRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFK 1369
Query: 574 LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLN 633
+ +PQ + SG++R N+ Y L L + LP E E G N
Sbjct: 1370 ITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGEN 1429
Query: 634 LSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQL 693
LS GQ+Q + LARA+ +I +LD+ +AVD + + I+ TV+ + H+L
Sbjct: 1430 LSVGQRQLVCLARALLRKTKILVLDEATAAVDLET-DDLIQSTIRTQFEDCTVLTIAHRL 1488
Query: 694 QYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEA 737
+ ++I+L+ G+I E G S+L+Q++G L M K+A
Sbjct: 1489 NTIMDYTRVIVLDKGEIQEYGAPSDLLQQRG----LFYSMAKDA 1528
>gi|134142335 ATP-binding cassette, sub-family C, member 1 isoform 5
[Homo sapiens]
Length = 1466
Score = 537 bits (1383), Expect = e-152
Identities = 370/1261 (29%), Positives = 613/1261 (48%), Gaps = 142/1261 (11%)
Query: 81 PAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEE 140
P P P +A S +T W+T L+++ R L+ + + L+ D S++ V L + W++E
Sbjct: 205 PNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKE 264
Query: 141 VSRRGIEKASVL-----------------------LVMLRFQR--TRLIFDAL---LGIC 172
++ + V+ L++ Q+ +F L G
Sbjct: 265 CAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPY 324
Query: 173 FCIASVLGPI---------LIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSS 223
F ++ I I+ ++++ + G LF++ C+++L
Sbjct: 325 FLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQY 384
Query: 224 WIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPLV 281
+ I + +R + AV + K + + +S GE ++ + D + Y ++
Sbjct: 385 FHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMI 444
Query: 282 LITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRV 341
+++ + +G + + +L+ P+ M Q + D RI++
Sbjct: 445 WSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKL 504
Query: 342 TSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVW 401
+E+L IK++K+Y WE F + +R++E K+L+K + ++ + T P +
Sbjct: 505 MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCT 564
Query: 402 VLIHTSLKLK--LTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQES 459
++ ++ L A AF LA N+LR + +P+ + + + ++ R + F E
Sbjct: 565 FAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEE 624
Query: 460 ---PVFYVQTLQDP--SKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRDAL 514
+ ++D + ++ AT +W ++ P +NG
Sbjct: 625 LEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNG--------------------- 663
Query: 515 GPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSL 574
I + +G ++ V G G GKSSLLSA+L EM +EG V ++GS+
Sbjct: 664 ---------------ITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSV 708
Query: 575 AYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNL 634
AYVPQQAWI + ++RENIL G ++ Y V+ C+L DLE+LP GD TEIGE+G+NL
Sbjct: 709 AYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNL 768
Query: 635 SGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECI--KKTLRGKTVVLVTHQ 692
SGGQKQR+SLARAVYS+ IYL DDPLSAVDAHVGKHIFE I K L+ KT +LVTH
Sbjct: 769 SGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHS 828
Query: 693 LQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAKIA--- 749
+ YL II++ GKI E G++ EL+ + G +A+ ++ A+++ QD +
Sbjct: 829 MSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTY---ASTEQEQDAEENGVTG 885
Query: 750 ------EKPKVESQALAT-----------SLEESLNGNAVPEHQLTQE------------ 780
E ++E+ L T S S +G+ H T E
Sbjct: 886 VSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETW 945
Query: 781 -----EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGS 835
++ + G + VY Y++A G ++ IF F+ V + S +WLS W +
Sbjct: 946 KLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHV-SALASNYWLSLWTDDPI 1004
Query: 836 GTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTAL 895
+ + ++ G + + ++ V+G + + V GI AS L
Sbjct: 1005 VNGTQEHTKVRLSVYGALGISQGIA----VFGYS------MAVSIGGIL------ASRCL 1048
Query: 896 HNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIV 955
H L + + R PMSFF+ P G L+N F+ +L+ +D ++P + F+ VI +++
Sbjct: 1049 HVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVI 1108
Query: 956 SVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVY 1015
+ +P ++ + +I F + + KRLE+ SRSP++SH +L G+S I +
Sbjct: 1109 LLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAF 1168
Query: 1016 GKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYS 1075
+ E FI Q D + + RW+A+RLE + N + L ALF S
Sbjct: 1169 EEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAG 1228
Query: 1076 FKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGW 1135
++V+ LQ+ + R+ E E AVER+ +Y + EAP ++ T+ P W
Sbjct: 1229 LVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSE-TEKEAPWQIQETAPPSSW 1287
Query: 1136 PQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPM 1195
PQ G + F++Y ++YR++ VL IN+TI G E VGIVGRTG+GKSSL + LFR+ E
Sbjct: 1288 PQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESA 1347
Query: 1196 AGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTF 1255
G I+IDG++I IGL DLR K+++IPQDPVL SG++R NLDPF +++D+++W +LE
Sbjct: 1348 EGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAH 1407
Query: 1256 L 1256
L
Sbjct: 1408 L 1408
Score = 42.7 bits (99), Expect = 0.002
Identities = 32/121 (26%), Positives = 48/121 (39%), Gaps = 13/121 (10%)
Query: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
L IN+ ++ G +G+ G TG+GKSSL + EG + + G
Sbjct: 1310 LRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFK 1369
Query: 574 LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLN 633
+ +PQ + SG++R N+ Y L L + LP E E G N
Sbjct: 1370 ITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGEN 1429
Query: 634 L 634
L
Sbjct: 1430 L 1430
>gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo
sapiens]
Length = 1464
Score = 524 bits (1349), Expect = e-148
Identities = 412/1372 (30%), Positives = 649/1372 (47%), Gaps = 178/1372 (12%)
Query: 73 PFRPKPRFPAPQPL----DNAGLFSYLTVSWLTPLMIQS----LRSRLDENTIP----PL 120
P+ +P P Q D S + +WL PL+ + LR D +P P
Sbjct: 155 PWAQEPLLPEDQEPEVAEDGESWLSRFSYAWLAPLLARGACGELRQPQDICRLPHRLQPT 214
Query: 121 SVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLG 180
+ + Q RLW G + + L +L+ T L F G
Sbjct: 215 YLARVFQAHWQEGARLWRALYGAFG--RCYLALGLLKLVGTMLGFS-------------G 259
Query: 181 PILI--IPKILEYSEEQLGN-VVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAA 237
P+L+ + LE +E L + +++ +GL L +++ + + ++ R A
Sbjct: 260 PLLLSLLVGFLEEGQEPLSHGLLYALGLAGGAVLGAVLQNQYGYEVY----KVTLQARGA 315
Query: 238 VSSFAFEKLIQFKSVIHITSGEAISFFTGDVNYL--FEGVCYG----PLVLITCASLVIC 291
V + + K +Q +GEA++ D L F G + PL L L+
Sbjct: 316 VLNILYCKALQL-GPSRPPTGEALNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQ 374
Query: 292 SISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKL 351
+ F+ G IL LLV V TR+ Q D R+++ +E+L+ I++
Sbjct: 375 QVGVAFVGGL-----ILALLLVPVNKVIATRIMASNQEMLQH-KDARVKLVTELLSGIRV 428
Query: 352 IKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFI---IPTVATAVWVLIHTSL 408
IK WE+ +E R +E L + +++ L + +++ +P V + V + + +
Sbjct: 429 IKFCGWEQALGARVEACRARE---LGRLRVIKYLDAACVYLWAALPVVISIVIFITYVLM 485
Query: 409 KLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQ 468
+LTA+ F+ LA + +L L + P + GL +K ++ R + F + P Q
Sbjct: 486 GHQLTATKVFTALALVRMLILPLNNFPWVINGLLEAKVSLDRIQLFL--DLPNHNPQAYY 543
Query: 469 DPSKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELH 528
P + A + W + LE +G + G SL E
Sbjct: 544 SPDCGRL--GAQIKWLLCSDPPAEPSTVLELHG----------ALFSWDPVGTSL--ETF 589
Query: 529 KINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG---SLAYVPQQAWIVS 585
+L V KGM++G+ G G GKSSLL+AI E+H L G V V+G Q+ WI
Sbjct: 590 ISHLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKGFGLATQEPWIQF 649
Query: 586 GNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLA 645
IR+NIL G +D Y +VL C+LN DL +LP GD TE+GE+G+ LSGGQ+ RI+LA
Sbjct: 650 ATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALA 709
Query: 646 RAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILL 705
RAVY ++++YLLDDPL+AVDA V H+ CI L T +L TH+ +YLE ++L+
Sbjct: 710 RAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTEYLERADAVLLM 769
Query: 706 ENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEE 765
E G++ G SE++ Q + K E + TA+ + P+ + L E+
Sbjct: 770 EAGRLIRAGPPSEIL----PLVQAVPKAWAENGQESDSATAQSVQNPEKTKEGLEE--EQ 823
Query: 766 SLNGNAVPEHQLTQEEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFW 825
S +G +L QEE +EG+++ VY Y +A G + I+ F ++L+ + W
Sbjct: 824 STSG------RLLQEESKKEGAVALHVYQAYWKAVGQGLALAIL-FSLLLMQATRNAADW 876
Query: 826 WLSYWLEQGSGTNSSRESNGTMADLGNIADNPQL-------------------------- 859
WLS+W+ Q NSS+E+ + + +PQL
Sbjct: 877 WLSHWISQLKAENSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDI 936
Query: 860 SFYQLVY----GLNALLLICVGVCSSGIFTKVTRKASTALHNKLFNKVFRCPMSFFDTIP 915
FY VY G+N+L + V +F T +A+ LH +L ++V P++FF+ P
Sbjct: 937 RFYLTVYATIAGVNSLCTLLRAV----LFAAGTLQAAATLHRRLLHRVLMAPVTFFNATP 992
Query: 916 IGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFI 975
GR+LN F+ D+ D LP L + ++ +L ++ P++LL+ + ++ +
Sbjct: 993 TGRILNRFSSDVACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYH 1052
Query: 976 YYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNY 1035
++ + +RL + + SPL+SH+ ++L GLS + G T F + RL +
Sbjct: 1053 VQRHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRC 1112
Query: 1036 LLLFLSSTRWMALRLEIMTNLVTLAVALFVAF---------GISSTPYSFKVMAVNIVLQ 1086
++ +W+ +RL++M V A+A G+ S+ + ++
Sbjct: 1113 QFATSATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSG 1172
Query: 1087 LASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEG--TSCPQGWPQHGEIIFQ 1144
L SSF +TEA +VER+ +Y + P +G GW G + FQ
Sbjct: 1173 LVSSF-------TQTEAMLVSVERLEEY----TCDLPQEPQGQPLQLGTGWLTQGGVEFQ 1221
Query: 1145 DYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGV 1204
D + YR P L G+ ++ E +GIVGRTGSGKSSL + LFRL+EP +GR+L+DGV
Sbjct: 1222 DVVLAYRPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGV 1281
Query: 1205 DICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALE------------ 1252
D + L LRS+L++IPQ+P L SGT+R NLDP H D+ +W AL+
Sbjct: 1282 DTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITSMG 1341
Query: 1253 ------------------------RTFLTKA-IILIDEATASIDMETDTLIQRTIREAFQ 1287
R LT A I+ IDEATAS+D +TD L+Q+TI + F
Sbjct: 1342 GLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFA 1401
Query: 1288 GCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATA 1339
TVL IAHR+ T+LN D +LV+ G+VVE D P LR +P SLF L+ ++
Sbjct: 1402 NKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLLQSS 1453
>gi|190343023 ATP-binding cassette, sub-family C, member 6 isoform 1
[Homo sapiens]
Length = 1503
Score = 519 bits (1336), Expect = e-147
Identities = 402/1373 (29%), Positives = 631/1373 (45%), Gaps = 182/1373 (13%)
Query: 73 PFRPK-PRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQ 131
PF P+ P+ P P A S T W++ L+ + R L + L ++S++ V
Sbjct: 191 PFFPEDPQQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVS 250
Query: 132 RLHRLWEEEVS------------RRGIE--KASVLLVMLRFQRT--RLIFDALLGICFCI 175
RL + W S R+G KA LR + + R + A+ + F
Sbjct: 251 RLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQV-FHS 309
Query: 176 ASVLGPILII---------PKILEYSEEQLGN----VVHGVGLCFALFLSECVKSLSFSS 222
+LG + +I PK+L E +G+ G L +FLS C+++L
Sbjct: 310 TFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQ 369
Query: 223 SWIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPL 280
+ + +R R+A++ + K++ S S G+ ++ + DV L E V Y
Sbjct: 370 NMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNG 429
Query: 281 VLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEV---SDQ 337
+ + +V+C + + ++G +A AI +L + PL F+++ K HH E D
Sbjct: 430 LWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISK---KRNHHQEEQMRQKDS 486
Query: 338 RIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVA 397
R R+TS +L K IK + WE F + +R +E L GL+ S++ ++ + +
Sbjct: 487 RARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLV 546
Query: 398 TAVWVLIHTSL-KLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFF- 455
V +HT + + + A AF L LN+L + F+P ++ L ++ + R F
Sbjct: 547 ALVVFAVHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLC 606
Query: 456 LQESPVFYVQTLQDPSKA----LVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPR 511
L+E V + S A + AT +W Q P
Sbjct: 607 LEEVDPGVVDSSSSGSAAGKDCITIHSATFAWSQESP----------------------- 643
Query: 512 DALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQ 571
P LH+INL V +G +L V G G+GKSSLLSA+L E+ +EG V ++
Sbjct: 644 -------------PCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIE 690
Query: 572 GSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERG 631
G++AYVPQ+AW+ + ++ EN+ G D +VL C+L D++ P G T IGE+G
Sbjct: 691 GAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQG 750
Query: 632 LNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKK--TLRGKTVVLV 689
+NLSGGQKQR+SLARAVY +YLLDDPL+A+DAHVG+H+F + I L+G T +LV
Sbjct: 751 MNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILV 810
Query: 690 THQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEA-TSDMLQDTAKI 748
TH L L II+L NG I E G++ EL+Q+KG L+ + + + +
Sbjct: 811 THALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQARQPGDRGEGETEPGTS 870
Query: 749 AEKPKVESQALATSLEESLNGNAVPEHQLTQEEEMEE--------------------GSL 788
+ P+ S L + +VPE T E E G +
Sbjct: 871 TKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRV 930
Query: 789 SWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMA 848
V+ Y++A G + +F F+ V + +WLS W
Sbjct: 931 KATVHLAYLRAVGTPLCLYALFLFLCQQV-ASFCRGYWLSLW------------------ 971
Query: 849 DLGNIADNPQLSFYQLVYGLNALLLICVGVCSS-GIFTKVT------RKASTALHNKLFN 901
AD+P + Q L + +G + G+F + +AS L +L
Sbjct: 972 -----ADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLW 1026
Query: 902 KVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPY 961
V R P+SFF+ PIG LLN F+ + + +D +P L+ + ++ V L+V+V +P
Sbjct: 1027 DVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATP- 1085
Query: 962 ILLMGAIIMVICFIYYMMFKKAIGV----FKRLENYSRSPLFSHILNSLQGLSSIHVYGK 1017
+ + ++ F+ Y F+ V +RLE+ S S + SH+ + QG + + +
Sbjct: 1086 ---LATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRT 1142
Query: 1018 TEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFK 1077
F++Q D L + RW+A +E++ N + A A +
Sbjct: 1143 QAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLV 1202
Query: 1078 VMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQ 1137
+V+ LQ+ + Q R + E +VER+ Y EAP + + WPQ
Sbjct: 1203 GFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDY-AWTPKEAPWRLPTCAAQPPWPQ 1261
Query: 1138 HGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197
G+I F+D+ ++YR P + G++ I E VGIVGRTG+GKSSL L RL E G
Sbjct: 1262 GGQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEG 1321
Query: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALE----- 1252
I IDGV I +GL LRS++S+IPQDP+L G++R NLD H+D+ IW ALE
Sbjct: 1322 GIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLK 1381
Query: 1253 --------------------------------RTFLTKA-IILIDEATASIDMETDTLIQ 1279
R L K I+++DEATA++D T+ +Q
Sbjct: 1382 ALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQ 1441
Query: 1280 RTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLF 1332
+ F CTVL+IAHR+ +V++C +LVM G+V E P L + G +
Sbjct: 1442 AMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFY 1494
Score = 92.4 bits (228), Expect = 3e-18
Identities = 57/216 (26%), Positives = 109/216 (50%), Gaps = 14/216 (6%)
Query: 530 INLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------SLAY 576
++ + G +G+ G TG+GKSSL S +L EG + + G ++
Sbjct: 1285 VSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISI 1344
Query: 577 VPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSG 636
+PQ + G++R N+ + + L L + LP + +RG +LS
Sbjct: 1345 IPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSV 1404
Query: 637 GQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYL 696
GQKQ + LARA+ QI +LD+ +AVD + + + TV+L+ H+L+ +
Sbjct: 1405 GQKQLLCLARALLRKTQILILDEATAAVDPGTELQM-QAMLGSWFAQCTVLLIAHRLRSV 1463
Query: 697 EFCGQIILLENGKICENGTHSELMQKKGKYAQLIQK 732
C ++++++ G++ E+G+ ++L+ +KG + +L Q+
Sbjct: 1464 MDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQE 1499
Score = 63.2 bits (152), Expect = 2e-09
Identities = 98/479 (20%), Positives = 193/479 (40%), Gaps = 46/479 (9%)
Query: 893 TALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVL 952
+A+ ++ KV +G ++N + D+++L + + + +L L +V+ +
Sbjct: 383 SAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFV 442
Query: 953 LIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRL--ENYSRSPLFSHILNSLQGLS 1010
+ +L P L A+ + + + + + KK + + SR+ L S IL + +
Sbjct: 443 YLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSK--- 499
Query: 1011 SIHVYGKTEDFISQFKRLTDAQNNYL----LLFLSSTRWMALRLEIMTNLVTLAVALFVA 1066
+I +G F+ + + + L LLF S + ++ T LV L V
Sbjct: 500 TIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSL----VSFQVSTFLVALVVFAVHT 555
Query: 1067 FGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQF-TAVERILQYMKMCVSEAPLH 1125
+ + K VL + + QA + + Q + +R++ ++ C+ E
Sbjct: 556 LVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFL--CLEEVDPG 613
Query: 1126 MEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLG 1185
+ +S I + +P LH INLT+ ++ +VG G+GKSSL
Sbjct: 614 VVDSSSSGSAAGKDCITIHSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLL 673
Query: 1186 MALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQ-------DP-----VLLSGTIR 1233
AL + + G + I+G + + E SV+ DP VL + ++
Sbjct: 674 SALLGELSKVEGFVSIEGA-VAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQ 732
Query: 1234 FNLDPFDRHTDQQIWD-------------ALERTFLTKAII-LIDEATASIDMETDTLIQ 1279
++D F I + +L R KA + L+D+ A++D +
Sbjct: 733 PDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVF 792
Query: 1280 RTI---REAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAAL 1335
+ QG T +++ H + + D I+V+ NG + E + L ++ G+L L
Sbjct: 793 NQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLL 851
>gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo
sapiens]
Length = 1581
Score = 518 bits (1335), Expect = e-146
Identities = 385/1415 (27%), Positives = 655/1415 (46%), Gaps = 172/1415 (12%)
Query: 55 RAAVPPWGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDE 114
R PP D +R + PF L S T W+ + + + +D
Sbjct: 202 REVKPPEDLQDLGVRFLQPF--------------VNLLSKGTYWWMNAFIKTAHKKPIDL 247
Query: 115 NTIPPLSVHDASDKNVQRLHRLWEEEVSR--RGIEKASVLLVMLR--FQRTRLIFDALLG 170
I L + + N QRL ++ +V + +G + A + L F R RL+ +
Sbjct: 248 RAIGKLPIAMRALTNYQRLCEAFDAQVRKDIQGTQGARAIWQALSHAFGR-RLVLSSTFR 306
Query: 171 ICFCIASVLGPILIIPKILEYSEEQ---------LGN--------VVHGVGLCFALFLSE 213
I + GP+ I + +E LG + + L LFL+
Sbjct: 307 ILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFLGVYFVSSQEFLANAYVLAVLLFLAL 366
Query: 214 CVKSLSFSSSWIINQRTAIRFRAAVSSFAFEKLIQFK----SVIHITSGEAISFFTGDVN 269
++ +S+ + T I R A+ + + K++ S+ +T+G+ + D N
Sbjct: 367 LLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTN 426
Query: 270 YLFEGVCYGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQH 329
L P + +++ I Y+I+G +A I +L+ P+ F+ +AQ
Sbjct: 427 QLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQR 486
Query: 330 HTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSIT 389
T E S++R++ T+E+L IKL+K+Y WE F +E RRKE L + S++
Sbjct: 487 STLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYTSISIFM 546
Query: 390 LFIIPTVATAVWVLIHTSL--KLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSA 447
IP A + + H S + + S+AF+ L+ ++L +F + V+ + +
Sbjct: 547 NTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVS 606
Query: 448 VMRFKKFFL-----QESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALELERNGH 502
V + +F +E + T Q P+ +Q +VN +
Sbjct: 607 VQKLSEFLSSAEIREEQCAPHEPTPQGPAS---------KYQAVPLRVVNRKRPARED-- 655
Query: 503 ASEGMTRPRDALGPEEEGNS-------LG----------PELHKINLVVSKGMMLGVCGN 545
G+T P +L P +G++ +G P L I + + +G + + G
Sbjct: 656 -CRGLTGPLQSLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQ 714
Query: 546 TGSGKSSLLSAILEEMHLLEGSV--------------------------GVQGSLAYVPQ 579
G GKSSLL A L EM + G+V +G +AY Q
Sbjct: 715 VGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQ 774
Query: 580 QAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQK 639
+ W+++ + ENI+ ++K RY V+ CSL D+++LP GD T+IGERG+NLSGGQ+
Sbjct: 775 KPWLLNATVEENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQR 834
Query: 640 QRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRG--KTVVLVTHQLQYLE 697
QRIS+ARA+Y + LDDP SA+D H+ H+ + I + LR +TVVLVTH+LQYL
Sbjct: 835 QRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLP 894
Query: 698 FCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTA---KIAEKPKV 754
II +++G I GT + + + + + + + ++ ++T K E P+
Sbjct: 895 HADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVTERKATEPPQG 954
Query: 755 ESQALATSLEESLNGNAVPEHQLTQEEE--------MEEGSLSWRVYHHYIQAAGGYMVS 806
S+A++ S + L E + + EE + + WR Y+ +AG ++S
Sbjct: 955 LSRAMS-SRDGLLQDEEEEEEEAAESEEDDNLSSMLHQRAEIPWRACAKYLSSAGILLLS 1013
Query: 807 CIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVY 866
++F ++ + L +W L+ W + + N + + + + Q VY
Sbjct: 1014 LLVFSQLLKHMVLVAIDYW-LAKWTDSALTLTPAAR---------NCSLSQECTLDQTVY 1063
Query: 867 GLNALLLICVGVCSSGIFTKVT-----RKASTALHNKLFNKVFRCPMSFFDTIPIGRLLN 921
+ +L +G+ + T VT K + LH L N++ PM FF+T P+G +LN
Sbjct: 1064 AMVFTVLCSLGIVLC-LVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILN 1122
Query: 922 CFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFK 981
F+ D +DQ +P E +L+ ++ L ++S ++P L+ + ++C+ F+
Sbjct: 1123 RFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVISYVTPVFLVALLPLAIVCYFIQKYFR 1182
Query: 982 KAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLS 1041
A ++L++ ++ PL SH +++GL++I + F + TD+ N L +
Sbjct: 1183 VASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTA 1242
Query: 1042 STRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMAVNIV--LQLASSFQATARIGL 1099
+ RW+ +R+E + V L A+ S ++ + + L +++ R
Sbjct: 1243 ANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLA 1302
Query: 1100 ETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLH 1159
+ E Q AV+RI +K + + P+ WP G+I Q+ ++Y + VL
Sbjct: 1303 DMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLK 1362
Query: 1160 GINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLS 1219
+N I + +GI GRTGSGKSS +A FR+V+ G I+IDG+DI + L LRS+LS
Sbjct: 1363 HVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLS 1422
Query: 1220 VIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALE--------------------------- 1252
+I QDPVL SGTIRFNLDP + +D +W+ALE
Sbjct: 1423 IILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFS 1482
Query: 1253 ----------RTFLTK-AIILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTV 1301
R F+ K +I ++DEATASIDM T+ ++Q+ + AF TV+ IAHRV T+
Sbjct: 1483 QGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTI 1542
Query: 1302 LNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALM 1336
L+ D ++V+ G ++EFD+PE L + S+FA+ +
Sbjct: 1543 LSADLVIVLKRGAILEFDKPEKLLSRKDSVFASFV 1577
>gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1312
Score = 518 bits (1335), Expect = e-146
Identities = 399/1366 (29%), Positives = 628/1366 (45%), Gaps = 181/1366 (13%)
Query: 79 RFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWE 138
++ P P A S T W++ L+ + R L + L ++S++ V RL + W
Sbjct: 7 KYTNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWM 66
Query: 139 EEVS------------RRGIE--KASVLLVMLRFQRT--RLIFDALLGICFCIASVLGPI 182
S R+G KA LR + + R + A+ + F +LG +
Sbjct: 67 RNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQV-FHSTFLLGTL 125
Query: 183 LII---------PKILEYSEEQLGN----VVHGVGLCFALFLSECVKSLSFSSSWIINQR 229
+I PK+L E +G+ G L +FLS C+++L + +
Sbjct: 126 SLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKV 185
Query: 230 TAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPLVLITCAS 287
+R R+A++ + K++ S S G+ ++ + DV L E V Y + +
Sbjct: 186 LQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVW 245
Query: 288 LVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEV---SDQRIRVTSE 344
+V+C + + ++G +A AI +L + PL F+++ K HH E D R R+TS
Sbjct: 246 IVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISK---KRNHHQEEQMRQKDSRARLTSS 302
Query: 345 VLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLI 404
+L K IK + WE F + +R +E L GL+ S++ ++ + + V +
Sbjct: 303 ILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAV 362
Query: 405 HTSL-KLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFF-LQESPVF 462
HT + + + A AF L LN+L + F+P ++ L ++ + R F L+E
Sbjct: 363 HTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDPG 422
Query: 463 YVQTLQDPSKA----LVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEE 518
V + S A + + AT +W Q P
Sbjct: 423 AVDSSSSGSAAGKDCITIQSATFAWSQESP------------------------------ 452
Query: 519 EGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVP 578
P LH+INL V +G +L V G G+GKSSLLSA+L E+ +EG V ++G++AYVP
Sbjct: 453 ------PCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVP 506
Query: 579 QQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQ 638
Q+AW+ + ++ EN+ G D +VL C+L D++ P G T IGE+G+NLSGGQ
Sbjct: 507 QEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQ 566
Query: 639 KQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKK--TLRGKTVVLVTHQLQYL 696
KQR+SLARAVY +YLLDDPL+A+DAHVG+H+F + I L+G T +LVTH L L
Sbjct: 567 KQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHIL 626
Query: 697 EFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEA-TSDMLQDTAKIAEKPKVE 755
II+L NG I E G++ EL+Q+KG L+ + + + + + P+
Sbjct: 627 PQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQARQPGDRGEGETEPGTSTKDPRGT 686
Query: 756 SQALATSLEESLNGNAVPEHQLTQEEEMEE--------------------GSLSWRVYHH 795
S L + +VPE T E E G + V+
Sbjct: 687 SAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKATVHLA 746
Query: 796 YIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIAD 855
Y++A G + +F F+ V + +WLS W AD
Sbjct: 747 YLRAVGTPLCLYALFLFLCQQV-ASFCRGYWLSLW-----------------------AD 782
Query: 856 NPQLSFYQLVYGLNALLLICVGVCSS-GIFTKVT------RKASTALHNKLFNKVFRCPM 908
+P + Q L + +G + G+F + +AS L +L V R P+
Sbjct: 783 DPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPI 842
Query: 909 SFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAI 968
SFF+ PIG LLN F+ + + +D +P L+ + ++ V L+V+V +P + +
Sbjct: 843 SFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATP----LATV 898
Query: 969 IMVICFIYYMMFKKAIGV----FKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQ 1024
++ F+ Y F+ V +RLE+ S S + SH+ + QG + + + F++Q
Sbjct: 899 AILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQ 958
Query: 1025 FKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMAVNIV 1084
D L + RW+A +E++ N + A A + +V+
Sbjct: 959 NNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAA 1018
Query: 1085 LQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQ 1144
LQ+ + Q R + E +VER+ Y EAP + + WPQ G+I FQ
Sbjct: 1019 LQVTQTLQWVVRNWTDLENSIVSVERMQDY-AWTPKEAPWRLPTCAAQPPWPQGGQIEFQ 1077
Query: 1145 DYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGV 1204
D+ ++YR P + G++ I E VGIVGRTG+GKSSL L RL E G I IDGV
Sbjct: 1078 DFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGV 1137
Query: 1205 DICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALE------------ 1252
I +GL LRS++S+IPQDP+L G++R NLD H+D+ IW ALE
Sbjct: 1138 PIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLP 1197
Query: 1253 -------------------------RTFLTKA-IILIDEATASIDMETDTLIQRTIREAF 1286
R L K I+++DEATA++D T+ +Q + F
Sbjct: 1198 GQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWF 1257
Query: 1287 QGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLF 1332
CTVL+IAHR+ +V++C +LVM G+V E P L + G +
Sbjct: 1258 AQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFY 1303
Score = 92.4 bits (228), Expect = 3e-18
Identities = 57/216 (26%), Positives = 109/216 (50%), Gaps = 14/216 (6%)
Query: 530 INLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------SLAY 576
++ + G +G+ G TG+GKSSL S +L EG + + G ++
Sbjct: 1094 VSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISI 1153
Query: 577 VPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSG 636
+PQ + G++R N+ + + L L + LP + +RG +LS
Sbjct: 1154 IPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSV 1213
Query: 637 GQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYL 696
GQKQ + LARA+ QI +LD+ +AVD + + + TV+L+ H+L+ +
Sbjct: 1214 GQKQLLCLARALLRKTQILILDEATAAVDPGTELQM-QAMLGSWFAQCTVLLIAHRLRSV 1272
Query: 697 EFCGQIILLENGKICENGTHSELMQKKGKYAQLIQK 732
C ++++++ G++ E+G+ ++L+ +KG + +L Q+
Sbjct: 1273 MDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQE 1308
Score = 64.3 bits (155), Expect = 7e-10
Identities = 99/479 (20%), Positives = 193/479 (40%), Gaps = 46/479 (9%)
Query: 893 TALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVL 952
+A+ ++ KV +G ++N + D+++L + + + +L L +V+ +
Sbjct: 192 SAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFV 251
Query: 953 LIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRL--ENYSRSPLFSHILNSLQGLS 1010
+ +L P L A+ + + + + + KK + + SR+ L S IL + +
Sbjct: 252 YLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSK--- 308
Query: 1011 SIHVYGKTEDFISQFKRLTDAQNNYL----LLFLSSTRWMALRLEIMTNLVTLAVALFVA 1066
+I +G F+ + + + L LLF S + ++ T LV L V
Sbjct: 309 TIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSL----VSFQVSTFLVALVVFAVHT 364
Query: 1067 FGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQF-TAVERILQYMKMCVSEAPLH 1125
+ + K VL + + QA + + Q + +R++ ++ C+ E
Sbjct: 365 LVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFL--CLEEVDPG 422
Query: 1126 MEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLG 1185
+S I Q + +P LH INLT+ ++ +VG G+GKSSL
Sbjct: 423 AVDSSSSGSAAGKDCITIQSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLL 482
Query: 1186 MALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQ-------DP-----VLLSGTIR 1233
AL + + G + I+G + + E SV+ DP VL + ++
Sbjct: 483 SALLGELSKVEGFVSIEGA-VAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQ 541
Query: 1234 FNLDPFDRHTDQQIWD-------------ALERTFLTKAII-LIDEATASIDMETDTLIQ 1279
++D F I + +L R KA + L+D+ A++D +
Sbjct: 542 PDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVF 601
Query: 1280 RTI---REAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAAL 1335
+ QG T +++ H + + D I+V+ NG + E + L ++ G+L L
Sbjct: 602 NQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLL 660
>gi|110832837 ATP-binding cassette, sub-family C, member 9 isoform
SUR2B [Homo sapiens]
Length = 1549
Score = 510 bits (1314), Expect = e-144
Identities = 391/1396 (28%), Positives = 644/1396 (46%), Gaps = 172/1396 (12%)
Query: 59 PPWGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIP 118
PP D +R + PF L S T W+ L+I + + +D I
Sbjct: 204 PPEDLQDLGVRFLQPF--------------VNLLSKATYWWMNTLIISAHKKPIDLKAIG 249
Query: 119 PLSVHDASDKNVQRLHRLWEEE---VSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCI 175
L + + N L +EE+ V+ S+ L M R ++ + +
Sbjct: 250 KLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADL 309
Query: 176 ASVLGPILIIPKILEYSEEQLG-NVVHGVG--------------LCFALFLSECVKSLSF 220
GP+ I + +E Q G N G+ L LFL+ ++
Sbjct: 310 LGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQRTFL 369
Query: 221 SSSWIINQRTAIRFRAAVSSFAFEKLIQFK----SVIHITSGEAISFFTGDVNYLFEGVC 276
+S+ + T I R A+ + + K+++ S+ +T G+ + + N L +
Sbjct: 370 QASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLF 429
Query: 277 YGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSD 336
P + +++ I Y ++G +A + +L+ P+ F+ +AQ T + S
Sbjct: 430 LCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYST 489
Query: 337 QRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTV 396
+R++ T+E+L IKL+K+Y WE F K +E+ R KE L+ L SL+ IP
Sbjct: 490 ERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIA 549
Query: 397 ATAVWVLIHTSLK-LKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFF 455
A + H L + AF+ L+ ++L +F + V+ + +V + +F
Sbjct: 550 AVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFL 609
Query: 456 LQESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVN----GALELERNGHASEGMTRPR 511
L + + + +L FE P +N G L+ ++ + RP
Sbjct: 610 LSDE--IGDDSWRTGESSLPFESCK-KHTGVQPKTINRKQPGRYHLDSYEQSTRRL-RPA 665
Query: 512 DAL--------GPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHL 563
+ G G+ L L I++ + G + + G G GKSSLL AIL EM
Sbjct: 666 ETEDIAIKVTNGYFSWGSGLAT-LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQT 724
Query: 564 LEGSVGVQG-----------------SLAYVPQQAWIVSGNIRENILMGGAYDKARYLQV 606
LEG V S+AY Q+ W+++ + ENI G ++K RY V
Sbjct: 725 LEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAV 784
Query: 607 LHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDA 666
CSL D++LLPFGD TEIGERG+NLSGGQ+QRI +ARA+Y + I LDDP SA+D
Sbjct: 785 TDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDI 844
Query: 667 HVGKHIFEECIKKTLRG--KTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKG 724
H+ H+ +E I K L+ +T+VLVTH+LQYL II +++G + GT ++ K
Sbjct: 845 HLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDV 904
Query: 725 K----YAQLIQKMHKEATSDMLQDTAKIAEKP---KVESQALATSLEESLNGNAVPEHQL 777
+ + L+ + +E DM D + K + S+ +E+ E +
Sbjct: 905 ELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMED--------EDEE 956
Query: 778 TQEEEMEEGSLS----------WRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWL 827
+EEE E+ ++S W+ Y+ +GG+ + ++ F +L + + +WL
Sbjct: 957 EEEEEDEDDNMSTVMRLRTKMPWKTCWRYL-TSGGFFLLILMIFSKLLKHSVIVAIDYWL 1015
Query: 828 SYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIF--- 884
+ W + S N+ + ++Y V G + L C +GIF
Sbjct: 1016 ATWTSEYSINNTGKADQ---------------TYY--VAGFSIL-------CGAGIFLCL 1051
Query: 885 -TKVTRK-----ASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFS 938
T +T + A+ LH+ L NK+ P+ FFDT P+G +LN F+ D +DQ +P
Sbjct: 1052 VTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTL 1111
Query: 939 EQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPL 998
E +L+ ++ + ++S +P L+ + V + F+ A + L++ ++ PL
Sbjct: 1112 ESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPL 1171
Query: 999 FSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVT 1058
H + +GL++I + F + LTD N L ++ RW+ +R + + +
Sbjct: 1172 LCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIV 1231
Query: 1059 LAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMC 1118
L ++ G S++ + + L + + R + E Q AV+++ ++ M
Sbjct: 1232 LTASIASISGSSNS--GLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTME 1289
Query: 1119 VSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTG 1178
M+ + P+ WPQ GEI D ++Y +N VL + I+ + VGI GRTG
Sbjct: 1290 SENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTG 1349
Query: 1179 SGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDP 1238
SGKSSL +A FR+V+ G+I+IDG+DI + L LRS+LS+I QDP+L SG+IRFNLDP
Sbjct: 1350 SGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDP 1409
Query: 1239 FDRHTDQQIWDALE-------------------------------------RTFLTKAII 1261
+ TD ++W+ALE R F+ K+ I
Sbjct: 1410 ECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSI 1469
Query: 1262 LI-DEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDR 1320
LI DEATASIDM T+ ++Q+ + AF TV+ IAHRV T+L D ++VM G ++E+D
Sbjct: 1470 LIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDT 1529
Query: 1321 PEVLRKKPGSLFAALM 1336
PE L + +FA+ +
Sbjct: 1530 PESLLAQENGVFASFV 1545
Score = 89.7 bits (221), Expect = 2e-17
Identities = 61/225 (27%), Positives = 105/225 (46%), Gaps = 15/225 (6%)
Query: 521 NSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------- 572
N+L P L + + G +G+CG TGSGKSSL A + + +G + + G
Sbjct: 1323 NNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPL 1382
Query: 573 -----SLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEI 627
L+ + Q + SG+IR N+ R + L L ++ LP G +
Sbjct: 1383 HTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVV 1442
Query: 628 GERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVV 687
E G N S GQ+Q LARA I ++D+ +++D ++I ++ + +TVV
Sbjct: 1443 TEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDM-ATENILQKVVMTAFADRTVV 1501
Query: 688 LVTHQLQYLEFCGQIILLENGKICENGT-HSELMQKKGKYAQLIQ 731
+ H++ + +I+++ G I E T S L Q+ G +A ++
Sbjct: 1502 TIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQENGVFASFVR 1546
>gi|110832839 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A-delta-14 [Homo sapiens]
Length = 1513
Score = 502 bits (1292), Expect = e-141
Identities = 390/1387 (28%), Positives = 639/1387 (46%), Gaps = 186/1387 (13%)
Query: 59 PPWGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIP 118
PP D +R + PF L S T W+ L+I + + +D I
Sbjct: 204 PPEDLQDLGVRFLQPF--------------VNLLSKATYWWMNTLIISAHKKPIDLKAIG 249
Query: 119 PLSVHDASDKNVQRLHRLWEEE---VSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCI 175
L + + N L +EE+ V+ S+ L M R ++ + +
Sbjct: 250 KLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADL 309
Query: 176 ASVLGPILIIPKILEYSEEQLG-NVVHGVG--------------LCFALFLSECVKSLSF 220
GP+ I + +E Q G N G+ L LFL+ ++
Sbjct: 310 LGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQRTFL 369
Query: 221 SSSWIINQRTAIRFRAAVSSFAFEKLIQFK----SVIHITSGEAISFFTGDVNYLFEGVC 276
+S+ + T I R A+ + + K+++ S+ +T G+ + + N L +
Sbjct: 370 QASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLF 429
Query: 277 YGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSD 336
P + +++ I Y ++G +A + +L+ P+ F+ +AQ T + S
Sbjct: 430 LCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYST 489
Query: 337 QRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTV 396
+R++ T+E+L IKL+K+Y WE F K +E+ R KE L+ L SL+ IP
Sbjct: 490 ERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIA 549
Query: 397 ATAVWVLIHTSLK-LKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFF 455
A + H L + AF+ L+ ++L +F + V+ + +V + +F
Sbjct: 550 AVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFL 609
Query: 456 LQESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRDALG 515
L + + + +L FE + G+V NG+ S G
Sbjct: 610 LSDE--IGDDSWRTGESSLPFESC-----KKHTGVVT-------NGYFSWG--------- 646
Query: 516 PEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG--- 572
S L I++ + G + + G G GKSSLL AIL EM LEG V
Sbjct: 647 ------SGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNE 700
Query: 573 --------------SLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLEL 618
S+AY Q+ W+++ + ENI G ++K RY V CSL D++L
Sbjct: 701 SEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDL 760
Query: 619 LPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIK 678
LPFGD TEIGERG+NLSGGQ+QRI +ARA+Y + I LDDP SA+D H+ H+ +E I
Sbjct: 761 LPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGIL 820
Query: 679 KTLRG--KTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGK----YAQLIQK 732
K L+ +T+VLVTH+LQYL II +++G + GT ++ K + + L+ +
Sbjct: 821 KFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNR 880
Query: 733 MHKEATSDMLQDTAKIAEKP---KVESQALATSLEESLNGNAVPEHQLTQEEEMEEGSLS 789
+E DM D + K + S+ +E+ E + +EEE E+ ++S
Sbjct: 881 QDQELEKDMEADQTTLERKTLRRAMYSREAKAQMED--------EDEEEEEEEDEDDNMS 932
Query: 790 ----------WRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNS 839
W+ Y+ +GG+ + ++ F +L + + +WL+ W + S N+
Sbjct: 933 TVMRLRTKMPWKTCWRYL-TSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINNT 991
Query: 840 SRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIF----TKVTRK----- 890
+ ++Y V G + L C +GIF T +T +
Sbjct: 992 GKADQ---------------TYY--VAGFSIL-------CGAGIFLCLVTSLTVEWMGLT 1027
Query: 891 ASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIA 950
A+ LH+ L NK+ P+ FFDT P+G +LN F+ D +DQ +P E +L+ ++
Sbjct: 1028 AAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLS 1087
Query: 951 VLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLS 1010
+ ++S +P L+ + V + F+ A + L++ ++ PL H + +GL+
Sbjct: 1088 AIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLT 1147
Query: 1011 SIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGIS 1070
+I + F + LTD N L ++ RW+ +R + + + L ++ G S
Sbjct: 1148 TIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSS 1207
Query: 1071 STPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTS 1130
++ + + L + + R + E Q AV+++ ++ M M+ +
Sbjct: 1208 NS--GLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQ 1265
Query: 1131 CPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFR 1190
P+ WPQ GEI D ++Y +N VL + I+ + VGI GRTGSGKSSL +A FR
Sbjct: 1266 VPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFR 1325
Query: 1191 LVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDA 1250
+V+ G+I+IDG+DI + L LRS+LS+I QDP+L SG+IRFNLDP + TD ++W+A
Sbjct: 1326 MVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEA 1385
Query: 1251 LE-------------------------------------RTFLTKAIILI-DEATASIDM 1272
LE R F+ K+ ILI DEATASIDM
Sbjct: 1386 LEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDM 1445
Query: 1273 ETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDR-PEVLRKKPGSL 1331
T+ ++Q+ + AF TV+ IAHRV+++++ +LV G +VE D P +L K G L
Sbjct: 1446 ATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNG-L 1504
Query: 1332 FAALMAT 1338
F+ L+ T
Sbjct: 1505 FSTLVMT 1511
>gi|110832835 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A [Homo sapiens]
Length = 1549
Score = 500 bits (1288), Expect = e-141
Identities = 392/1399 (28%), Positives = 645/1399 (46%), Gaps = 174/1399 (12%)
Query: 59 PPWGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIP 118
PP D +R + PF L S T W+ L+I + + +D I
Sbjct: 204 PPEDLQDLGVRFLQPF--------------VNLLSKATYWWMNTLIISAHKKPIDLKAIG 249
Query: 119 PLSVHDASDKNVQRLHRLWEEE---VSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCI 175
L + + N L +EE+ V+ S+ L M R ++ + +
Sbjct: 250 KLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADL 309
Query: 176 ASVLGPILIIPKILEYSEEQLG-NVVHGVG--------------LCFALFLSECVKSLSF 220
GP+ I + +E Q G N G+ L LFL+ ++
Sbjct: 310 LGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQRTFL 369
Query: 221 SSSWIINQRTAIRFRAAVSSFAFEKLIQFK----SVIHITSGEAISFFTGDVNYLFEGVC 276
+S+ + T I R A+ + + K+++ S+ +T G+ + + N L +
Sbjct: 370 QASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLF 429
Query: 277 YGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSD 336
P + +++ I Y ++G +A + +L+ P+ F+ +AQ T + S
Sbjct: 430 LCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYST 489
Query: 337 QRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTV 396
+R++ T+E+L IKL+K+Y WE F K +E+ R KE L+ L SL+ IP
Sbjct: 490 ERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIA 549
Query: 397 ATAVWVLIHTSLK-LKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFF 455
A + H L + AF+ L+ ++L +F + V+ + +V + +F
Sbjct: 550 AVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFL 609
Query: 456 LQESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVN----GALELERNGHASEGMTRPR 511
L + + + +L FE P +N G L+ ++ + RP
Sbjct: 610 LSDE--IGDDSWRTGESSLPFESCK-KHTGVQPKTINRKQPGRYHLDSYEQSTRRL-RPA 665
Query: 512 DAL--------GPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHL 563
+ G G+ L L I++ + G + + G G GKSSLL AIL EM
Sbjct: 666 ETEDIAIKVTNGYFSWGSGLAT-LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQT 724
Query: 564 LEGSVGVQG-----------------SLAYVPQQAWIVSGNIRENILMGGAYDKARYLQV 606
LEG V S+AY Q+ W+++ + ENI G ++K RY V
Sbjct: 725 LEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAV 784
Query: 607 LHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDA 666
CSL D++LLPFGD TEIGERG+NLSGGQ+QRI +ARA+Y + I LDDP SA+D
Sbjct: 785 TDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDI 844
Query: 667 HVGKHIFEECIKKTLRG--KTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKG 724
H+ H+ +E I K L+ +T+VLVTH+LQYL II +++G + GT ++ K
Sbjct: 845 HLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDV 904
Query: 725 K----YAQLIQKMHKEATSDMLQDTAKIAEKP---KVESQALATSLEESLNGNAVPEHQL 777
+ + L+ + +E DM D + K + S+ +E+ E +
Sbjct: 905 ELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMED--------EDEE 956
Query: 778 TQEEEMEEGSLS----------WRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWL 827
+EEE E+ ++S W+ Y+ +GG+ + ++ F +L + + +WL
Sbjct: 957 EEEEEDEDDNMSTVMRLRTKMPWKTCWRYL-TSGGFFLLILMIFSKLLKHSVIVAIDYWL 1015
Query: 828 SYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIF--- 884
+ W + S N+ + ++Y V G + L C +GIF
Sbjct: 1016 ATWTSEYSINNTGKADQ---------------TYY--VAGFSIL-------CGAGIFLCL 1051
Query: 885 -TKVTRK-----ASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFS 938
T +T + A+ LH+ L NK+ P+ FFDT P+G +LN F+ D +DQ +P
Sbjct: 1052 VTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTL 1111
Query: 939 EQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPL 998
E +L+ ++ + ++S +P L+ + V + F+ A + L++ ++ PL
Sbjct: 1112 ESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPL 1171
Query: 999 FSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVT 1058
H + +GL++I + F + LTD N L ++ RW+ +R + + +
Sbjct: 1172 LCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIV 1231
Query: 1059 LAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMC 1118
L ++ G S++ + + L + + R + E Q AV+++ ++ M
Sbjct: 1232 LTASIASISGSSNS--GLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTME 1289
Query: 1119 VSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTG 1178
M+ + P+ WPQ GEI D ++Y +N VL + I+ + VGI GRTG
Sbjct: 1290 SENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTG 1349
Query: 1179 SGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDP 1238
SGKSSL +A FR+V+ G+I+IDG+DI + L LRS+LS+I QDP+L SG+IRFNLDP
Sbjct: 1350 SGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDP 1409
Query: 1239 FDRHTDQQIWDALE-------------------------------------RTFLTKAII 1261
+ TD ++W+ALE R F+ K+ I
Sbjct: 1410 ECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSI 1469
Query: 1262 LI-DEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDR 1320
LI DEATASIDM T+ ++Q+ + AF TV+ IAHRV+++++ +LV G +VE D
Sbjct: 1470 LIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDT 1529
Query: 1321 -PEVLRKKPGSLFAALMAT 1338
P +L K G LF+ L+ T
Sbjct: 1530 VPNLLAHKNG-LFSTLVMT 1547
>gi|134142345 ATP-binding cassette, sub-family C, member 1 isoform 3
[Homo sapiens]
Length = 1475
Score = 470 bits (1209), Expect = e-132
Identities = 357/1374 (25%), Positives = 617/1374 (44%), Gaps = 232/1374 (16%)
Query: 81 PAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEE 140
P P P +A S +T W+T L+++ R L+ + + L+ D S++ V L + W++E
Sbjct: 205 PNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKE 264
Query: 141 VSRRGIEKASVL-----------------------LVMLRFQR--TRLIFDAL---LGIC 172
++ + V+ L++ Q+ +F L G
Sbjct: 265 CAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPY 324
Query: 173 FCIASVLGPI---------LIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSS 223
F ++ I I+ ++++ + G LF++ C+++L
Sbjct: 325 FLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQY 384
Query: 224 WIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPLV 281
+ I + +R + AV + K + + +S GE ++ + D + Y ++
Sbjct: 385 FHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMI 444
Query: 282 LITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRV 341
+++ + +G + + +L+ P+ M Q + D RI++
Sbjct: 445 WSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKL 504
Query: 342 TSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVW 401
+E+L IK++K+Y WE F + +R++E K+L+K + ++ + T P +
Sbjct: 505 MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCT 564
Query: 402 VLIHTSLKLK--LTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQES 459
++ ++ L A AF LA N+LR + +P+ + + + ++ R + F E
Sbjct: 565 FAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEE 624
Query: 460 ---PVFYVQTLQDP--SKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRDAL 514
+ ++D + ++ AT +W ++ P +NG
Sbjct: 625 LEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNG--------------------- 663
Query: 515 GPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSL 574
I + +G ++ V G G GKSSLLSA+L EM +EG V ++GS+
Sbjct: 664 ---------------ITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSV 708
Query: 575 AYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNL 634
AYVPQQAWI + ++RENIL G ++ Y V+ C+L DLE+ L
Sbjct: 709 AYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEI---------------L 753
Query: 635 SGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQ 694
G + I KT +LVTH +
Sbjct: 754 PSGDRTEIG---------------------------------------EKTRILVTHSMS 774
Query: 695 YLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAKIA----- 749
YL II++ GKI E G++ EL+ + G +A+ ++ A+++ QD +
Sbjct: 775 YLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTY---ASTEQEQDAEENGVTGVS 831
Query: 750 ----EKPKVESQALAT-----------SLEESLNGNAVPEHQLTQE-------------- 780
E ++E+ L T S S +G+ H T E
Sbjct: 832 GPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKL 891
Query: 781 ---EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGT 837
++ + G + VY Y++A G ++ IF F+ V + S +WLS W +
Sbjct: 892 MEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVS-ALASNYWLSLWTDDPIVN 950
Query: 838 NSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHN 897
+ + ++ G + + ++ V+G + + V GI AS LH
Sbjct: 951 GTQEHTKVRLSVYGALGISQGIA----VFGYS------MAVSIGGIL------ASRCLHV 994
Query: 898 KLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSV 957
L + + R PMSFF+ P G L+N F+ +L+ +D ++P + F+ VI +++ +
Sbjct: 995 DLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILL 1054
Query: 958 LSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGK 1017
+P ++ + +I F + + KRLE+ SRSP++SH +L G+S I + +
Sbjct: 1055 ATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEE 1114
Query: 1018 TEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFK 1077
E FI Q D + + RW+A+RLE + N + L ALF S
Sbjct: 1115 QERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLV 1174
Query: 1078 VMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQ 1137
++V+ LQ+ + R+ E E AVER+ +Y + EAP ++ T+ P WPQ
Sbjct: 1175 GLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET-EKEAPWQIQETAPPSSWPQ 1233
Query: 1138 HGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197
G + F++Y ++YR++ VL IN+TI G E VGIVGRTG+GKSSL + LFR+ E G
Sbjct: 1234 VGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEG 1293
Query: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALE----- 1252
I+IDG++I IGL DLR K+++IPQDPVL SG++R NLDPF +++D+++W +LE
Sbjct: 1294 EIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLK 1353
Query: 1253 --------------------------------RTFLTKA-IILIDEATASIDMETDTLIQ 1279
R L K I+++DEATA++D+ETD LIQ
Sbjct: 1354 DFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQ 1413
Query: 1280 RTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFA 1333
TIR F+ CTVL IAHR+ T+++ ++V+ G++ E+ P L ++ G ++
Sbjct: 1414 STIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYS 1467
Score = 90.9 bits (224), Expect = 7e-18
Identities = 65/224 (29%), Positives = 105/224 (46%), Gaps = 18/224 (8%)
Query: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
L IN+ ++ G +G+ G TG+GKSSL + EG + + G
Sbjct: 1254 LRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFK 1313
Query: 574 LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLN 633
+ +PQ + SG++R N+ Y L L + LP E E G N
Sbjct: 1314 ITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGEN 1373
Query: 634 LSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQL 693
LS GQ+Q + LARA+ +I +LD+ +AVD + + I+ TV+ + H+L
Sbjct: 1374 LSVGQRQLVCLARALLRKTKILVLDEATAAVDLET-DDLIQSTIRTQFEDCTVLTIAHRL 1432
Query: 694 QYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEA 737
+ ++I+L+ G+I E G S+L+Q++G L M K+A
Sbjct: 1433 NTIMDYTRVIVLDKGEIQEYGAPSDLLQQRG----LFYSMAKDA 1472
Score = 48.1 bits (113), Expect = 6e-05
Identities = 92/474 (19%), Positives = 188/474 (39%), Gaps = 72/474 (15%)
Query: 890 KASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVI 949
+ TA+ ++ K S + +G ++N + D ++ L + + +++
Sbjct: 394 RIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVIL 453
Query: 950 AVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKA----IGVFKRLENYSRSPLFSHILNS 1005
A+ L+ L P +L A+++++ + +M K + K +N R L + ILN
Sbjct: 454 ALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDN--RIKLMNEILNG 511
Query: 1006 LQGLS--SIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWM-----------ALRLEI 1052
++ L + + K + + + L + + L + + W+ A+ + I
Sbjct: 512 IKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTI 571
Query: 1053 MTNLVTLAVALFVA---FGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVE 1109
N + A FV+ F I P + M ++ ++Q + S + E + ++E
Sbjct: 572 DENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIE 631
Query: 1110 RILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHE 1169
R P+ G + I ++ + + P L+GI +I
Sbjct: 632 R-----------RPVKDGGGT--------NSITVRNATFTWARSDPPTLNGITFSIPEGA 672
Query: 1170 VVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLS 1229
+V +VG+ G GKSSL AL ++ + G + I G ++ +PQ + +
Sbjct: 673 LVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG-------------SVAYVPQQAWIQN 719
Query: 1230 GTIRFNLDPFDRHTDQQIWDALERTFLTKAIILID-EATASIDMETDTLIQRTIREAFQG 1288
++R N+ Q+ + R+ + +L D E S D R
Sbjct: 720 DSLRENI-----LFGCQLEEPYYRSVIQACALLPDLEILPSGD-----------RTEIGE 763
Query: 1289 CTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATATSS 1342
T +++ H ++ + D I+VM GK+ E + L + G+ FA + T S+
Sbjct: 764 KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGA-FAEFLRTYAST 816
>gi|134142340 ATP-binding cassette, sub-family C, member 1 isoform 2
[Homo sapiens]
Length = 1472
Score = 423 bits (1087), Expect = e-118
Identities = 266/781 (34%), Positives = 410/781 (52%), Gaps = 98/781 (12%)
Query: 630 RGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECI--KKTLRGKTVV 687
+G+NLSGGQKQR+SLARAVYS+ IYL DDPLSAVDAHVGKHIFE I K L+ KT +
Sbjct: 705 KGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRI 764
Query: 688 LVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAK 747
LVTH + YL II++ GKI E G++ EL+ + G +A+ ++ A+++ QD +
Sbjct: 765 LVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTY---ASTEQEQDAEE 821
Query: 748 IA---------EKPKVESQALAT-----------SLEESLNGNAVPEHQLTQE------- 780
E ++E+ L T S S +G+ H T E
Sbjct: 822 NGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAK 881
Query: 781 ----------EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYW 830
++ + G + VY Y++A G ++ IF F+ V + S +WLS W
Sbjct: 882 KEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVS-ALASNYWLSLW 940
Query: 831 LEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRK 890
+ + + ++ G + + ++ V+G + + V GI
Sbjct: 941 TDDPIVNGTQEHTKVRLSVYGALGISQGIA----VFGYS------MAVSIGGIL------ 984
Query: 891 ASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIA 950
AS LH L + + R PMSFF+ P G L+N F+ +L+ +D ++P + F+ VI
Sbjct: 985 ASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIG 1044
Query: 951 VLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLS 1010
+++ + +P ++ + +I F + + KRLE+ SRSP++SH +L G+S
Sbjct: 1045 ACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVS 1104
Query: 1011 SIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGIS 1070
I + + E FI Q D + + RW+A+RLE + N + L ALF
Sbjct: 1105 VIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRH 1164
Query: 1071 STPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTS 1130
S ++V+ LQ+ + R+ E E AVER+ +Y + EAP ++ T+
Sbjct: 1165 SLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET-EKEAPWQIQETA 1223
Query: 1131 CPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFR 1190
P WPQ G + F++Y ++YR++ VL IN+TI G E VGIVGRTG+GKSSL + LFR
Sbjct: 1224 PPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFR 1283
Query: 1191 LVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDA 1250
+ E G I+IDG++I IGL DLR K+++IPQDPVL SG++R NLDPF +++D+++W +
Sbjct: 1284 INESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTS 1343
Query: 1251 LE-------------------------------------RTFLTKA-IILIDEATASIDM 1272
LE R L K I+++DEATA++D+
Sbjct: 1344 LELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDL 1403
Query: 1273 ETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLF 1332
ETD LIQ TIR F+ CTVL IAHR+ T+++ ++V+ G++ E+ P L ++ G +
Sbjct: 1404 ETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFY 1463
Query: 1333 A 1333
+
Sbjct: 1464 S 1464
Score = 106 bits (265), Expect = 1e-22
Identities = 110/540 (20%), Positives = 220/540 (40%), Gaps = 86/540 (15%)
Query: 81 PAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEE 140
P P P +A S +T W+T L+++ R L+ + + L+ D S++ V L + W++E
Sbjct: 205 PNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKE 264
Query: 141 VSRRGIEKASVL-----------------------LVMLRFQR--TRLIFDAL---LGIC 172
++ + V+ L++ Q+ +F L G
Sbjct: 265 CAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPY 324
Query: 173 FCIASVLGPI---------LIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSS 223
F ++ I I+ ++++ + G LF++ C+++L
Sbjct: 325 FLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQY 384
Query: 224 WIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPLV 281
+ I + +R + AV + K + + +S GE ++ + D + Y ++
Sbjct: 385 FHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMI 444
Query: 282 LITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRV 341
+++ + +G + + +L+ P+ M Q + D RI++
Sbjct: 445 WSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKL 504
Query: 342 TSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITL----FIIPTVA 397
+E+L IK++K+Y WE F + +R++E K+L+K + ++ + T F++
Sbjct: 505 MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCT 564
Query: 398 TAVWVLIHTSLKLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQ 457
AV+V I + L A AF LA N+LR + +P+ + + + ++ R + F
Sbjct: 565 FAVYVTIDEN--NILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSH 622
Query: 458 ES---PVFYVQTLQD--PSKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRD 512
E + ++D + ++ AT +W ++ P +NG
Sbjct: 623 EELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNG------------------- 663
Query: 513 ALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG 572
I + +G ++ V G G GKSSLLSA+L EM +EG V ++G
Sbjct: 664 -----------------ITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG 706
Score = 90.9 bits (224), Expect = 7e-18
Identities = 65/224 (29%), Positives = 105/224 (46%), Gaps = 18/224 (8%)
Query: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
L IN+ ++ G +G+ G TG+GKSSL + EG + + G
Sbjct: 1251 LRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFK 1310
Query: 574 LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLN 633
+ +PQ + SG++R N+ Y L L + LP E E G N
Sbjct: 1311 ITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGEN 1370
Query: 634 LSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQL 693
LS GQ+Q + LARA+ +I +LD+ +AVD + + I+ TV+ + H+L
Sbjct: 1371 LSVGQRQLVCLARALLRKTKILVLDEATAAVDLET-DDLIQSTIRTQFEDCTVLTIAHRL 1429
Query: 694 QYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEA 737
+ ++I+L+ G+I E G S+L+Q++G L M K+A
Sbjct: 1430 NTIMDYTRVIVLDKGEIQEYGAPSDLLQQRG----LFYSMAKDA 1469
Score = 50.8 bits (120), Expect = 9e-06
Identities = 92/476 (19%), Positives = 186/476 (39%), Gaps = 79/476 (16%)
Query: 890 KASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVI 949
+ TA+ ++ K S + +G ++N + D ++ L + + +++
Sbjct: 394 RIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVIL 453
Query: 950 AVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKA----IGVFKRLENYSRSPLFSHILNS 1005
A+ L+ L P +L A+++++ + +M K + K +N R L + ILN
Sbjct: 454 ALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDN--RIKLMNEILNG 511
Query: 1006 LQGLS--SIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWM-----------ALRLEI 1052
++ L + + K + + + L + + L + + W+ A+ + I
Sbjct: 512 IKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTI 571
Query: 1053 MTNLVTLAVALFVA---FGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVE 1109
N + A FV+ F I P + M ++ ++Q + S + E + ++E
Sbjct: 572 DENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIE 631
Query: 1110 RILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHE 1169
R P+ G + I ++ + + P L+GI +I
Sbjct: 632 R-----------RPVKDGGGT--------NSITVRNATFTWARSDPPTLNGITFSIPEGA 672
Query: 1170 VVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLS 1229
+V +VG+ G GKSSL AL ++ + G + I GV+ LS + V L+
Sbjct: 673 LVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGVN------------LSGGQKQRVSLA 720
Query: 1230 GTIRFNLDPFDRHTDQQIWDALERTFLTKAIILIDEATASIDMETDTLIQRTI---REAF 1286
+ N D I L D+ +++D I + +
Sbjct: 721 RAVYSNAD----------------------IYLFDDPLSAVDAHVGKHIFENVIGPKGML 758
Query: 1287 QGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATATSS 1342
+ T +++ H ++ + D I+VM GK+ E + L + G+ FA + T S+
Sbjct: 759 KNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGA-FAEFLRTYAST 813
>gi|157502203 ATP-binding cassette, sub-family C, member 4 isoform 2
[Homo sapiens]
Length = 859
Score = 391 bits (1004), Expect = e-108
Identities = 272/888 (30%), Positives = 436/888 (49%), Gaps = 81/888 (9%)
Query: 83 PQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEEVS 142
P PL +A L S + WL PL + RL+E+ + + D S + L W++EV
Sbjct: 10 PNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVL 69
Query: 143 R--RGIEKASVLLVMLR-FQRTRLIFDALLGICFCI---ASVLGPILIIPKILEYSE--E 194
R +K S+ +++ + ++ L+ LGI I A V+ PI + KI+ Y E +
Sbjct: 70 RAENDAQKPSLTRAIIKCYWKSYLV----LGIFTLIEESAKVIQPIFL-GKIINYFENYD 124
Query: 195 QLGNVVHGVGLCFALFLSECVKSLSFSSSWIIN--QRTAIRFRAAVSSFAFEKLIQFKSV 252
+ +V +A L+ C L+ Q +R R A+ + K ++ ++
Sbjct: 125 PMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNM 184
Query: 253 I--HITSGEAISFFTGDVNYLFEGVCY------GPLVLITCASLVICSISSYFIIGYTAF 304
T+G+ ++ + DVN + + GPL I +L+ + IG +
Sbjct: 185 AMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALL------WMEIGISCL 238
Query: 305 IAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKI 364
+ +++ PL ++ + T+ +D RIR +EV+T I++IKMY WEK F+ +
Sbjct: 239 AGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNL 298
Query: 365 IEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLASL 424
I +LR+KE + + ++ + + F + V + L +TAS F +
Sbjct: 299 ITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLY 358
Query: 425 NLLRLSV-FFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVF-EEATLS 482
+RL+V F P A++ ++ + ++ R + F L + + L K +V ++ T
Sbjct: 359 GAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAF 418
Query: 483 WQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLGV 542
W + ASE P L ++ V G +L V
Sbjct: 419 WDK-----------------ASET------------------PTLQGLSFTVRPGELLAV 443
Query: 543 CGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKAR 602
G G+GKSSLLSA+L E+ G V V G +AYV QQ W+ SG +R NIL G Y+K R
Sbjct: 444 VGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKER 503
Query: 603 YLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLS 662
Y +V+ C+L +DL+LL GD+T IG+RG LSGGQK R++LARAVY D IYLLDDPLS
Sbjct: 504 YEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLS 563
Query: 663 AVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQK 722
AVDA V +H+FE CI + L K +LVTHQLQYL+ QI++L++GK+ + GT++E ++
Sbjct: 564 AVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKS 623
Query: 723 KGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALA-TSLEESLNGNAVPEHQLTQ-- 779
+ L++K ++E+ + T + + ES + S SL A+ E Q T+
Sbjct: 624 GIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGAL-ESQDTENV 682
Query: 780 -----EEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQG 834
EE EG + ++ Y +Y +A ++V + + WWLSYW
Sbjct: 683 PVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYW---- 738
Query: 835 SGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTA 894
N N T+ GN+ + L++Y +Y + + G+ S + V +S
Sbjct: 739 --ANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQT 796
Query: 895 LHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFL 942
LHNK+F + + P+ FFD PIGR+LN F+ D+ LD LLP+ F+
Sbjct: 797 LHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFI 844
Score = 57.4 bits (137), Expect = 9e-08
Identities = 75/391 (19%), Positives = 150/391 (38%), Gaps = 46/391 (11%)
Query: 894 ALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLL 953
A+ + ++ K R G+++N + D+ + DQ+ +F L IAV
Sbjct: 169 AMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVT-VFLHFLWAGPLQAIAVTA 227
Query: 954 IVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIH 1013
++ + L G +++I F K + + + G+ I
Sbjct: 228 LLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIK 287
Query: 1014 VYGKTEDF-----------ISQFKRLTDAQNNYLLLFLSSTR---WMALRLEIMTNLVTL 1059
+Y + F IS+ R + + L F S+++ ++ ++ V
Sbjct: 288 MYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVIT 347
Query: 1060 AVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCV 1119
A +FVA T Y + V + A + A + + F ++ I Q +
Sbjct: 348 ASRVFVAV----TLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLP 403
Query: 1120 SEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGS 1179
S+ + W + E TPT L G++ T+R E++ +VG G+
Sbjct: 404 SDGKKMVHVQDFTAFWDKASE-------------TPT-LQGLSFTVRPGELLAVVGPVGA 449
Query: 1180 GKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPF 1239
GKSSL A+ + P S GL + +++ + Q P + SGT+R N+
Sbjct: 450 GKSSLLSAVLGELAP-------------SHGLVSVHGRIAYVSQQPWVFSGTLRSNILFG 496
Query: 1240 DRHTDQQIWDALERTFLTKAIILIDEATASI 1270
++ ++ ++ L K + L+++ ++
Sbjct: 497 KKYEKERYEKVIKACALKKDLQLLEDGDLTV 527
>gi|134142342 ATP-binding cassette, sub-family C, member 1 isoform 4
[Homo sapiens]
Length = 1416
Score = 347 bits (889), Expect = 6e-95
Identities = 225/725 (31%), Positives = 364/725 (50%), Gaps = 96/725 (13%)
Query: 684 KTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQ 743
KT +LVTH + YL II++ GKI E G++ EL+ + G +A+ ++ A+++ Q
Sbjct: 705 KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTY---ASTEQEQ 761
Query: 744 DTAKIA---------EKPKVESQALAT-----------SLEESLNGNAVPEHQLTQE--- 780
D + E ++E+ L T S S +G+ H T E
Sbjct: 762 DAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQK 821
Query: 781 --------------EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWW 826
++ + G + VY Y++A G ++ IF F+ V + S +W
Sbjct: 822 AEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVS-ALASNYW 880
Query: 827 LSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTK 886
LS W + + + ++ G + + ++ V+G + + V GI
Sbjct: 881 LSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIA----VFGYS------MAVSIGGIL-- 928
Query: 887 VTRKASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSL 946
AS LH L + + R PMSFF+ P G L+N F+ +L+ +D ++P + F+
Sbjct: 929 ----ASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLF 984
Query: 947 MVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSL 1006
VI +++ + +P ++ + +I F + + KRLE+ SRSP++SH +L
Sbjct: 985 NVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETL 1044
Query: 1007 QGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVA 1066
G+S I + + E FI Q D + + RW+A+RLE + N + L ALF
Sbjct: 1045 LGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAV 1104
Query: 1067 FGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHM 1126
S ++V+ LQ+ + R+ E E AVER+ +Y + EAP +
Sbjct: 1105 ISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET-EKEAPWQI 1163
Query: 1127 EGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGM 1186
+ T+ P WPQ G + F++Y ++YR++ VL IN+TI G E VGIVGRTG+GKSSL +
Sbjct: 1164 QETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTL 1223
Query: 1187 ALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQ 1246
LFR+ E G I+IDG++I IGL DLR K+++IPQDPVL SG++R NLDPF +++D++
Sbjct: 1224 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEE 1283
Query: 1247 IWDALE-------------------------------------RTFLTKA-IILIDEATA 1268
+W +LE R L K I+++DEATA
Sbjct: 1284 VWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATA 1343
Query: 1269 SIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKP 1328
++D+ETD LIQ TIR F+ CTVL IAHR+ T+++ ++V+ G++ E+ P L ++
Sbjct: 1344 AVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQR 1403
Query: 1329 GSLFA 1333
G ++
Sbjct: 1404 GLFYS 1408
Score = 108 bits (270), Expect = 3e-23
Identities = 122/600 (20%), Positives = 243/600 (40%), Gaps = 103/600 (17%)
Query: 81 PAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEE 140
P P P +A S +T W+T L+++ R L+ + + L+ D S++ V L + W++E
Sbjct: 205 PNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKE 264
Query: 141 VSRRGIEKASVL-----------------------LVMLRFQR--TRLIFDAL---LGIC 172
++ + V+ L++ Q+ +F L G
Sbjct: 265 CAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPY 324
Query: 173 FCIASVLGPI---------LIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSS 223
F ++ I I+ ++++ + G LF++ C+++L
Sbjct: 325 FLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQY 384
Query: 224 WIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPLV 281
+ I + +R + AV + K + + +S GE ++ + D + Y ++
Sbjct: 385 FHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMI 444
Query: 282 LITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRV 341
+++ + +G + + +L+ P+ M Q + D RI++
Sbjct: 445 WSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKL 504
Query: 342 TSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITL----FIIPTVA 397
+E+L IK++K+Y WE F + +R++E K+L+K + ++ + T F++
Sbjct: 505 MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCT 564
Query: 398 TAVWVLIHTSLKLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQ 457
AV+V I + L A AF LA N+LR + +P+ + + + ++ R + F
Sbjct: 565 FAVYVTIDEN--NILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSH 622
Query: 458 ES---PVFYVQTLQD--PSKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRD 512
E + ++D + ++ AT +W ++ P +NG
Sbjct: 623 EELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNG------------------- 663
Query: 513 ALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQ- 571
I + +G ++ V G G GKSSLLSA+L EM +EG V ++
Sbjct: 664 -----------------ITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKT 706
Query: 572 -----GSLAYVPQQAWIV---------SGNIRENILMGGAYDKARYLQVLHCCSLNRDLE 617
S++Y+PQ I+ G+ +E + GA+ A +L+ +D E
Sbjct: 707 RILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAF--AEFLRTYASTEQEQDAE 764
Score = 90.9 bits (224), Expect = 7e-18
Identities = 65/224 (29%), Positives = 105/224 (46%), Gaps = 18/224 (8%)
Query: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
L IN+ ++ G +G+ G TG+GKSSL + EG + + G
Sbjct: 1195 LRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFK 1254
Query: 574 LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLN 633
+ +PQ + SG++R N+ Y L L + LP E E G N
Sbjct: 1255 ITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGEN 1314
Query: 634 LSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQL 693
LS GQ+Q + LARA+ +I +LD+ +AVD + + I+ TV+ + H+L
Sbjct: 1315 LSVGQRQLVCLARALLRKTKILVLDEATAAVDLET-DDLIQSTIRTQFEDCTVLTIAHRL 1373
Query: 694 QYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEA 737
+ ++I+L+ G+I E G S+L+Q++G L M K+A
Sbjct: 1374 NTIMDYTRVIVLDKGEIQEYGAPSDLLQQRG----LFYSMAKDA 1413
Score = 39.3 bits (90), Expect = 0.026
Identities = 64/332 (19%), Positives = 134/332 (40%), Gaps = 41/332 (12%)
Query: 890 KASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVI 949
+ TA+ ++ K S + +G ++N + D ++ L + + +++
Sbjct: 394 RIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVIL 453
Query: 950 AVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKA----IGVFKRLENYSRSPLFSHILNS 1005
A+ L+ L P +L A+++++ + +M K + K +N R L + ILN
Sbjct: 454 ALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDN--RIKLMNEILNG 511
Query: 1006 LQGLS--SIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWM-----------ALRLEI 1052
++ L + + K + + + L + + L + + W+ A+ + I
Sbjct: 512 IKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTI 571
Query: 1053 MTNLVTLAVALFVA---FGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVE 1109
N + A FV+ F I P + M ++ ++Q + S + E + ++E
Sbjct: 572 DENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIE 631
Query: 1110 RILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHE 1169
R P+ G + I ++ + + P L+GI +I
Sbjct: 632 R-----------RPVKDGGGT--------NSITVRNATFTWARSDPPTLNGITFSIPEGA 672
Query: 1170 VVGIVGRTGSGKSSLGMALFRLVEPMAGRILI 1201
+V +VG+ G GKSSL AL ++ + G + I
Sbjct: 673 LVAVVGQVGCGKSSLLSALLAEMDKVEGHVAI 704
>gi|90421313 cystic fibrosis transmembrane conductance regulator
[Homo sapiens]
Length = 1480
Score = 250 bits (639), Expect = 6e-66
Identities = 180/642 (28%), Positives = 314/642 (48%), Gaps = 20/642 (3%)
Query: 85 PLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEEVSRR 144
PL+ A + S L SW P++ + R RL+ + I + D++D ++L R W+ E++ +
Sbjct: 5 PLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASK 64
Query: 145 GIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLGPILIIPKILEYS----EEQLGNVV 200
+ ++ + R R +F + + + P+L+ I Y EE+ +
Sbjct: 65 --KNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIY 122
Query: 201 HGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSSFAFEKLIQFKSVI--HITSG 258
G+GLC LF+ V++L + ++ R A+ S ++K ++ S + I+ G
Sbjct: 123 LGIGLCL-LFI---VRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIG 178
Query: 259 EAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAV 318
+ +S + ++N EG+ V I + + + ++ +AF + +++
Sbjct: 179 QLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQA 238
Query: 319 FMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEK 378
+ RM +K + + +R+ +TSE++ I+ +K Y WE+ K+IE+LR+ E KL K
Sbjct: 239 GLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRK 298
Query: 379 CGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLASLNLLRLSVFF-VPIA 437
V+ S F + VL + +K + F+ ++ +LR++V P A
Sbjct: 299 AAYVRYFNSSAFFFSGFFVVFLSVLPYALIK-GIILRKIFTTISFCIVLRMAVTRQFPWA 357
Query: 438 VKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALEL 497
V+ +S A+ + + F ++ L + +V E T W++ + A +
Sbjct: 358 VQTWYDSLGAINKIQDFLQKQEYKTLEYNLT--TTEVVMENVTAFWEEGFGELFEKAKQN 415
Query: 498 ERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAI 557
N S G D+L P L IN + +G +L V G+TG+GK+SLL I
Sbjct: 416 NNNRKTSNG----DDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVI 471
Query: 558 LEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLE 617
+ E+ EG + G +++ Q +WI+ G I+ENI+ G +YD+ RY V+ C L D+
Sbjct: 472 MGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDIS 531
Query: 618 LLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECI 677
D +GE G+ LSGGQ+ RISLARAVY D +YLLD P +D K IFE C+
Sbjct: 532 KFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCV 591
Query: 678 KKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSEL 719
K + KT +LVT ++++L+ +I++L G GT SEL
Sbjct: 592 CKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSEL 633
Score = 233 bits (595), Expect = 7e-61
Identities = 174/658 (26%), Positives = 302/658 (45%), Gaps = 82/658 (12%)
Query: 731 QKMHKEATSDMLQDTAKIAEKPKVE-----------SQALATSLEESLNGNAVPEHQLTQ 779
Q +H++ T+ T K++ P+ SQ + E +N + E
Sbjct: 781 QNIHRKTTAS----TRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDD 836
Query: 780 EEEMEEGSLSWRVYHHYIQAAGGY---MVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSG 836
E + + +W Y YI ++ C++ F + L + W L Q G
Sbjct: 837 MESIPAVT-TWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVL--WLLGNTPLQDKG 893
Query: 837 TNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALH 896
NS+ N + A + I + + G+ A L+ +G S LH
Sbjct: 894 -NSTHSRNNSYAVI--ITSTSSYYVFYIYVGV-ADTLLAMGFFRGLPLVHTLITVSKILH 949
Query: 897 NKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVS 956
+K+ + V + PMS +T+ G +LN F+ D+ LD LLP+ F+ L L+VI + +V+
Sbjct: 950 HKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVA 1009
Query: 957 VLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYG 1016
VL PYI + ++V + F + K+LE+ RSP+F+H++ SL+GL ++ +G
Sbjct: 1010 VLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFG 1069
Query: 1017 KTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSF 1076
+ F + F + + L+LS+ RW +R+E++ + +AV F++ +
Sbjct: 1070 RQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVT-FISILTTGEGEGR 1128
Query: 1077 KVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAP------------- 1123
+ + + + + S+ Q ++ ++ +V R+ +++ M P
Sbjct: 1129 VGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLS 1188
Query: 1124 --LHMEGTSCPQG--WPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGS 1179
+ +E + + WP G++ +D KY + +L I+ +I + VG++GRTGS
Sbjct: 1189 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGS 1248
Query: 1180 GKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPF 1239
GKS+L A RL+ G I IDGV SI L+ R VIPQ + SGT R NLDP+
Sbjct: 1249 GKSTLLSAFLRLLN-TEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPY 1307
Query: 1240 DRHTDQQIWD-------------------------------------ALERTFLTKA-II 1261
++ +DQ+IW L R+ L+KA I+
Sbjct: 1308 EQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKIL 1367
Query: 1262 LIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFD 1319
L+DE +A +D T +I+RT+++AF CTV++ HR+ +L C LV+ KV ++D
Sbjct: 1368 LLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYD 1425
Score = 90.5 bits (223), Expect = 1e-17
Identities = 72/263 (27%), Positives = 126/263 (47%), Gaps = 21/263 (7%)
Query: 518 EEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG----- 572
E GN++ L I+ +S G +G+ G TGSGKS+LLSA L ++ EG + + G
Sbjct: 1221 EGGNAI---LENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEGEIQIDGVSWDS 1276
Query: 573 --------SLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDM 624
+ +PQ+ +I SG R+N+ + +V L +E P
Sbjct: 1277 ITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLD 1336
Query: 625 TEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGK 684
+ + G LS G KQ + LAR+V S +I LLD+P + +D V I +K+
Sbjct: 1337 FVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDP-VTYQIIRRTLKQAFADC 1395
Query: 685 TVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQD 744
TV+L H+++ + C Q +++E K+ + + +L+ ++ + Q I + ++
Sbjct: 1396 TVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPH-RN 1454
Query: 745 TAKIAEKPKVESQALATSLEESL 767
++K KP++ AL EE +
Sbjct: 1455 SSKCKSKPQI--AALKEETEEEV 1475
Score = 37.4 bits (85), Expect = 0.098
Identities = 20/53 (37%), Positives = 30/53 (56%), Gaps = 1/53 (1%)
Query: 1157 VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDG-VDICS 1208
VL IN I +++ + G TG+GK+SL M + +EP G+I G + CS
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCS 492
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 179 bits (455), Expect = 1e-44
Identities = 274/1210 (22%), Positives = 487/1210 (40%), Gaps = 231/1210 (19%)
Query: 258 GEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIGYT-AFIAILCYLLVFPL 316
GE + T DV+ + EG+ G + + S+ + + FI+G+T + L L + P+
Sbjct: 169 GELNTRLTDDVSKINEGI--GDKIGMFFQSMA--TFFTGFIVGFTRGWKLTLVILAISPV 224
Query: 317 AVFMTRMAVKAQHHTSEVSDQRI-------RVTSEVLTCIKLIKMYTWEKPFAKIIEDLR 369
+ K S +D+ + V EVL I+ + + +K ++L
Sbjct: 225 LGLSAAVWAKI---LSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQK------KELE 275
Query: 370 RKERKLLE--KCGLVQSLTS------ITLFIIPTVATAVWVLIHTSLKLKLTASMAFSML 421
R + L E + G+ +++T+ L I + A A W L + + ++
Sbjct: 276 RYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVF 335
Query: 422 ASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEATL 481
S+ + SV +++ N++ A K + + +
Sbjct: 336 FSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSI-----------------DSY 378
Query: 482 SWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLG 541
S P + G LE RN H S P + + L +NL V G +
Sbjct: 379 SKSGHKPDNIKGNLEF-RNVHFSY----------PSRKEVKI---LKGLNLKVQSGQTVA 424
Query: 542 VCGNTGSGKSSLLSAILEEMHLLEGSVGVQGS-------------LAYVPQQAWIVSGNI 588
+ GN+G GKS+ + + EG V V G + V Q+ + + I
Sbjct: 425 LVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTI 484
Query: 589 RENILMGGAYDKARYLQ-VLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARA 647
ENI G ++ + + + LP T +GERG LSGGQKQRI++ARA
Sbjct: 485 AENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARA 544
Query: 648 VYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLEN 707
+ + +I LLD+ SA+D + + + + K +G+T +++ H+L + I ++
Sbjct: 545 LVRNPKILLLDEATSALDTE-SEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDD 603
Query: 708 GKICENGTHSELMQKKGKYAQLI------QKMHKEATSDMLQ---DTAKIAEKPKVESQA 758
G I E G H ELM++KG Y +L+ ++ E +D + D +++ S
Sbjct: 604 GVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRSSLI 663
Query: 759 LATSLEESLNGNAVPEHQLTQEEEMEEG---SLSWRVYHHYIQAAGGYMVS--CIIFFFV 813
S S+ G+ + +L+ +E ++E WR+ + ++V C I
Sbjct: 664 RKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGG 723
Query: 814 VLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLL 873
+ F IFS + + D+P+ + L +LL
Sbjct: 724 LQPAFAIIFS----------------------KIIGVFTRIDDPETK--RQNSNLFSLLF 759
Query: 874 ICVGVCS-------SGIFTKVTRKASTALHNKLFNKVFRCPMSFFD--TIPIGRLLNCFA 924
+ +G+ S F K + L +F + R +S+FD G L A
Sbjct: 760 LALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLA 819
Query: 925 GDLEQ----LDQLLPIFSEQFLVLSLMVI-------AVLLIVSVLSPYILLMGAIIMVIC 973
D Q + L + ++ L +I + L++ + P I + G + M +
Sbjct: 820 NDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKML 879
Query: 974 FIYYMMFKK-----------AIGVFKRLENYSRSPLFSHI-LNSLQ-----GLSSIHVYG 1016
+ KK AI F+ + + ++ F H+ SLQ L H++G
Sbjct: 880 SGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFG 939
Query: 1017 KTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSF 1076
T F +Y F +A +L M+ L V V FG
Sbjct: 940 ITFSFTQAMMYF-----SYAGCFRFGAYLVAHKL--MSFEDVLLVFSAVVFG-------- 984
Query: 1077 KVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPL----HMEG--TS 1130
MAV V A + +A+ +A I M + + PL EG +
Sbjct: 985 -AMAVGQVSSFAPDY---------AKAKISAAHII-----MIIEKTPLIDSYSTEGLMPN 1029
Query: 1131 CPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFR 1190
+G GE++F + R + P VL G++L ++ + + +VG +G GKS++ L R
Sbjct: 1030 TLEGNVTFGEVVF---NYPTRPDIP-VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLER 1085
Query: 1191 LVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFD--RHTDQQ-- 1246
+P+AG++L+DG +I + ++ LR+ L ++ Q+P+L +I N+ D R Q+
Sbjct: 1086 FYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEI 1145
Query: 1247 -----------IWDALERTFLTKA--------------------------IILIDEATAS 1269
++L + TK I+L+DEAT++
Sbjct: 1146 VRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSA 1205
Query: 1270 IDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPG 1329
+D E++ ++Q + +A +G T +VIAHR++T+ N D I+V NG+V E + L + G
Sbjct: 1206 LDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKG 1265
Query: 1330 SLFAALMATA 1339
F+ + A
Sbjct: 1266 IYFSMVSVQA 1275
>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
[Homo sapiens]
Length = 1321
Score = 167 bits (424), Expect = 5e-41
Identities = 214/919 (23%), Positives = 381/919 (41%), Gaps = 158/919 (17%)
Query: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
L+ +N+V+ G M + G +G+GKS+ L I EG V V G
Sbjct: 438 LNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQ 497
Query: 574 LAYVPQQAWIVSGNIRENILMGGAYDKAR-YLQVLHCCSLNRDLELLPFGDMTEIGERGL 632
+ V Q+ + S I ENI G +Q + + LP T +GE G
Sbjct: 498 IGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGG 557
Query: 633 NLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQ 692
+SGGQKQR+++ARA+ + +I LLD SA+D + + + +E + K G T++ V H+
Sbjct: 558 QMSGGQKQRVAIARALIRNPKILLLDMATSALD-NESEAMVQEVLSKIQHGHTIISVAHR 616
Query: 693 LQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI-----------QKMHKEATSDM 741
L + II E+G E GTH EL+++KG Y L+ ++ K+AT D
Sbjct: 617 LSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQSQGNQALNEEDIKDATEDD 676
Query: 742 L----------QDTAKIAEKPKVESQALATSLEESLNGNAVPEHQLTQEEEMEEGSLSWR 791
+ QD+ + + + + +SQ E L AV +H+ T EE+ ++ +
Sbjct: 677 MLARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPL---AVVDHKSTYEEDRKDKDIP-- 731
Query: 792 VYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLG 851
++ A V I+ F ++ + S NGT+ L
Sbjct: 732 -VQEEVEPA---PVRRILKFSAPEWPYMLVGSV---------------GAAVNGTVTPLY 772
Query: 852 NIADNPQLSFYQLV------YGLNALLLICVGVCSSGIFTKVTRKASTALHNKLFNKVFR 905
+ L + + +N + L+ V + +FT+ + + A +L K R
Sbjct: 773 AFLFSQILGTFSIPDKEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLR 832
Query: 906 ---------CPMSFFDTI--PIGRLLNCFAGDLEQL-----DQLLPIFSEQFLVLSLMVI 949
+++FD + G L A D Q+ Q+ I + V M+I
Sbjct: 833 KFGFRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMII 892
Query: 950 A------VLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHIL 1003
A + L++ P++ L GA + + K+A+ + ++ N
Sbjct: 893 AFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITN----------- 941
Query: 1004 NSLQGLSSIHVYGKTEDFI--------SQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTN 1055
+L + ++ GK FI FK N Y F + + +
Sbjct: 942 EALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANIYGFCFAFA--------QCIMF 993
Query: 1056 LVTLAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYM 1115
+ A + + IS+ F + ++ + S A R T + A ++
Sbjct: 994 IANSASYRYGGYLISNEGLHFSYV-FRVISAVVLSATALGRAFSYTPSYAKAKISAARFF 1052
Query: 1116 KMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPT-VLHGINLTIRGHEVVGIV 1174
++ + P+ + T+ + G+I F D Y + VL+G++++I + + V
Sbjct: 1053 QLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFV 1112
Query: 1175 GRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRF 1234
G +G GKS+ L R +P G+++IDG D + ++ LRS + ++ Q+PVL + +I
Sbjct: 1113 GSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMD 1172
Query: 1235 NLD--------PFDR----HTDQQIWDAL-----------------------ERTFLTKA 1259
N+ P +R Q+ D + +R + +A
Sbjct: 1173 NIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARA 1232
Query: 1260 II------LIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNG 1313
I+ L+DEAT+++D E++ +Q + +A +G T +VIAHR++T+ N D I VM G
Sbjct: 1233 IVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQG 1292
Query: 1314 KVVEFDRPEVLRKKPGSLF 1332
V+E E L + G+ +
Sbjct: 1293 VVIEKGTHEELMAQKGAYY 1311
Score = 93.2 bits (230), Expect = 2e-18
Identities = 62/220 (28%), Positives = 110/220 (50%), Gaps = 17/220 (7%)
Query: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
L+ +++ +S G L G++G GKS+ + + +G V + G +
Sbjct: 1096 LNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSN 1155
Query: 574 LAYVPQQAWIVSGNIRENILMGGAYDKA---RYLQVLHCCSLNRDLELLPFGDMTEIGER 630
+ V Q+ + + +I +NI G + R + L+ + LP T +G +
Sbjct: 1156 IGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQ 1215
Query: 631 GLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVT 690
G LS G+KQRI++ARA+ D +I LLD+ SA+D K + + + K G+T +++
Sbjct: 1216 GSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTV-QVALDKAREGRTCIVIA 1274
Query: 691 HQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730
H+L ++ I ++ G + E GTH ELM +KG Y +L+
Sbjct: 1275 HRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLV 1314
Score = 87.8 bits (216), Expect = 6e-17
Identities = 63/234 (26%), Positives = 114/234 (48%), Gaps = 40/234 (17%)
Query: 1139 GEIIFQDYHMKYRDNTPT-VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197
GEI F + Y +L+ +N+ I+ E+ +VG +G+GKS+ + R +P G
Sbjct: 418 GEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEG 477
Query: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNL-------------------DP 1238
+ +DG DI S+ ++ LR ++ ++ Q+PVL S TI N+ +
Sbjct: 478 MVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANA 537
Query: 1239 FDRHTD-QQIWDAL-------------ERTFLTKA------IILIDEATASIDMETDTLI 1278
++ D Q +D L +R + +A I+L+D AT+++D E++ ++
Sbjct: 538 YNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMV 597
Query: 1279 QRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLF 1332
Q + + G T++ +AHR++TV D I+ +G VE E L ++ G F
Sbjct: 598 QEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYF 651
>gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C
[Homo sapiens]
Length = 1232
Score = 114 bits (285), Expect = 6e-25
Identities = 68/222 (30%), Positives = 117/222 (52%), Gaps = 17/222 (7%)
Query: 525 PELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGS----------- 573
P L ++L V KG L + G++G GKS+++ + L G+V + G
Sbjct: 1003 PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLR 1062
Query: 574 --LAYVPQQAWIVSGNIRENILMGG---AYDKARYLQVLHCCSLNRDLELLPFGDMTEIG 628
L V Q+ + +I ENI G + + +++ +E LP T +G
Sbjct: 1063 AQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVG 1122
Query: 629 ERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVL 688
++G LSGGQKQRI++ARA+ QI LLD+ SA+D K + +E + K G+T ++
Sbjct: 1123 DKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEK-VVQEALDKAREGRTCIV 1181
Query: 689 VTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730
+ H+L ++ I++ +NG++ E+GTH +L+ +KG Y ++
Sbjct: 1182 IAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMV 1223
Score = 102 bits (253), Expect = 3e-21
Identities = 69/218 (31%), Positives = 109/218 (50%), Gaps = 15/218 (6%)
Query: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGS------------- 573
L +NL V G + + G++G GKS+ + I EG++ + G
Sbjct: 412 LKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREI 471
Query: 574 LAYVPQQAWIVSGNIRENILMG-GAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGL 632
+ V Q+ + S I ENI G G + + + + LP T +GERG
Sbjct: 472 IGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGA 531
Query: 633 NLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQ 692
LSGGQKQRI++ARA+ + +I LLD+ SA+D + + + K G+T +++ H+
Sbjct: 532 QLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV-QAALDKAREGRTTIVIAHR 590
Query: 693 LQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730
L + I E+G I E G+HSELM+K+G Y +L+
Sbjct: 591 LSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLV 628
Score = 100 bits (250), Expect = 7e-21
Identities = 70/244 (28%), Positives = 124/244 (50%), Gaps = 44/244 (18%)
Query: 1139 GEIIFQDYHMKY--RDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMA 1196
G I F + Y R N P VL G++L ++ + + +VG +G GKS++ L R +P+A
Sbjct: 985 GNITFNEVVFNYPTRANVP-VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLA 1043
Query: 1197 GRILIDGVDICSIGLEDLRSKLSVIPQDPVL-----------------------LSGTIR 1233
G +L+DG + + ++ LR++L ++ Q+P+L +S
Sbjct: 1044 GTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKA 1103
Query: 1234 FNLDPF-------------DRHTD----QQIWDALERTFLTK-AIILIDEATASIDMETD 1275
N+ PF D+ T Q+ A+ R + + I+L+DEAT+++D E++
Sbjct: 1104 ANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESE 1163
Query: 1276 TLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAAL 1335
++Q + +A +G T +VIAHR++T+ N D I+V NG+V E + L + G F+ +
Sbjct: 1164 KVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMV 1223
Query: 1336 MATA 1339
A
Sbjct: 1224 SVQA 1227
Score = 100 bits (249), Expect = 9e-21
Identities = 76/247 (30%), Positives = 119/247 (48%), Gaps = 41/247 (16%)
Query: 1139 GEIIFQDYHMKYRDNTPT-VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197
G + F D H Y +L G+NL ++ + V +VG +G GKS+ + RL +P G
Sbjct: 392 GNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEG 451
Query: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFN---------LDPFDRHTDQ--- 1245
I IDG DI + + LR + V+ Q+PVL S TI N +D + +
Sbjct: 452 TINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANA 511
Query: 1246 --------QIWDAL-------------ERTFLTKA------IILIDEATASIDMETDTLI 1278
Q +D L +R + +A I+L+DEAT+++D E++ +
Sbjct: 512 YEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV 571
Query: 1279 QRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAAL-MA 1337
Q + +A +G T +VIAHR++TV N D I +G +VE L KK G F + M
Sbjct: 572 QAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQ 631
Query: 1338 TATSSLR 1344
T+ S ++
Sbjct: 632 TSGSQIQ 638
>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
[Homo sapiens]
Length = 1279
Score = 114 bits (285), Expect = 6e-25
Identities = 68/222 (30%), Positives = 117/222 (52%), Gaps = 17/222 (7%)
Query: 525 PELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGS----------- 573
P L ++L V KG L + G++G GKS+++ + L G+V + G
Sbjct: 1050 PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLR 1109
Query: 574 --LAYVPQQAWIVSGNIRENILMGG---AYDKARYLQVLHCCSLNRDLELLPFGDMTEIG 628
L V Q+ + +I ENI G + + +++ +E LP T +G
Sbjct: 1110 AQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVG 1169
Query: 629 ERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVL 688
++G LSGGQKQRI++ARA+ QI LLD+ SA+D K + +E + K G+T ++
Sbjct: 1170 DKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEK-VVQEALDKAREGRTCIV 1228
Query: 689 VTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730
+ H+L ++ I++ +NG++ E+GTH +L+ +KG Y ++
Sbjct: 1229 IAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMV 1270
Score = 102 bits (253), Expect = 3e-21
Identities = 69/218 (31%), Positives = 109/218 (50%), Gaps = 15/218 (6%)
Query: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGS------------- 573
L +NL V G + + G++G GKS+ + I EG++ + G
Sbjct: 412 LKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREI 471
Query: 574 LAYVPQQAWIVSGNIRENILMG-GAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGL 632
+ V Q+ + S I ENI G G + + + + LP T +GERG
Sbjct: 472 IGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGA 531
Query: 633 NLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQ 692
LSGGQKQRI++ARA+ + +I LLD+ SA+D + + + K G+T +++ H+
Sbjct: 532 QLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV-QAALDKAREGRTTIVIAHR 590
Query: 693 LQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730
L + I E+G I E G+HSELM+K+G Y +L+
Sbjct: 591 LSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLV 628
Score = 100 bits (250), Expect = 7e-21
Identities = 70/244 (28%), Positives = 124/244 (50%), Gaps = 44/244 (18%)
Query: 1139 GEIIFQDYHMKY--RDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMA 1196
G I F + Y R N P VL G++L ++ + + +VG +G GKS++ L R +P+A
Sbjct: 1032 GNITFNEVVFNYPTRANVP-VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLA 1090
Query: 1197 GRILIDGVDICSIGLEDLRSKLSVIPQDPVL-----------------------LSGTIR 1233
G +L+DG + + ++ LR++L ++ Q+P+L +S
Sbjct: 1091 GTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKA 1150
Query: 1234 FNLDPF-------------DRHTD----QQIWDALERTFLTK-AIILIDEATASIDMETD 1275
N+ PF D+ T Q+ A+ R + + I+L+DEAT+++D E++
Sbjct: 1151 ANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESE 1210
Query: 1276 TLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAAL 1335
++Q + +A +G T +VIAHR++T+ N D I+V NG+V E + L + G F+ +
Sbjct: 1211 KVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMV 1270
Query: 1336 MATA 1339
A
Sbjct: 1271 SVQA 1274
Score = 100 bits (249), Expect = 9e-21
Identities = 76/247 (30%), Positives = 119/247 (48%), Gaps = 41/247 (16%)
Query: 1139 GEIIFQDYHMKYRDNTPT-VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197
G + F D H Y +L G+NL ++ + V +VG +G GKS+ + RL +P G
Sbjct: 392 GNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEG 451
Query: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFN---------LDPFDRHTDQ--- 1245
I IDG DI + + LR + V+ Q+PVL S TI N +D + +
Sbjct: 452 TINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANA 511
Query: 1246 --------QIWDAL-------------ERTFLTKA------IILIDEATASIDMETDTLI 1278
Q +D L +R + +A I+L+DEAT+++D E++ +
Sbjct: 512 YEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV 571
Query: 1279 QRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAAL-MA 1337
Q + +A +G T +VIAHR++TV N D I +G +VE L KK G F + M
Sbjct: 572 QAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQ 631
Query: 1338 TATSSLR 1344
T+ S ++
Sbjct: 632 TSGSQIQ 638
>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
[Homo sapiens]
Length = 1286
Score = 111 bits (277), Expect = 5e-24
Identities = 68/229 (29%), Positives = 117/229 (51%), Gaps = 24/229 (10%)
Query: 525 PELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGV-------------- 570
P L ++L V KG L + G++G GKS+++ + L G+V V
Sbjct: 1050 PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKK 1109
Query: 571 ------QGSLAYVPQQAWIVSGNIRENILMGG---AYDKARYLQVLHCCSLNRDLELLPF 621
+ L V Q+ + +I ENI G + + +++ +E LP
Sbjct: 1110 LNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPH 1169
Query: 622 GDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTL 681
T +G++G LSGGQKQRI++ARA+ QI LLD+ SA+D K + +E + K
Sbjct: 1170 KYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEK-VVQEALDKAR 1228
Query: 682 RGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730
G+T +++ H+L ++ I++ +NG++ E+GTH +L+ +KG Y ++
Sbjct: 1229 EGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMV 1277
Score = 102 bits (253), Expect = 3e-21
Identities = 69/218 (31%), Positives = 109/218 (50%), Gaps = 15/218 (6%)
Query: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGS------------- 573
L +NL V G + + G++G GKS+ + I EG++ + G
Sbjct: 412 LKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREI 471
Query: 574 LAYVPQQAWIVSGNIRENILMG-GAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGL 632
+ V Q+ + S I ENI G G + + + + LP T +GERG
Sbjct: 472 IGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGA 531
Query: 633 NLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQ 692
LSGGQKQRI++ARA+ + +I LLD+ SA+D + + + K G+T +++ H+
Sbjct: 532 QLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV-QAALDKAREGRTTIVIAHR 590
Query: 693 LQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730
L + I E+G I E G+HSELM+K+G Y +L+
Sbjct: 591 LSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLV 628
Score = 100 bits (249), Expect = 9e-21
Identities = 76/247 (30%), Positives = 119/247 (48%), Gaps = 41/247 (16%)
Query: 1139 GEIIFQDYHMKYRDNTPT-VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197
G + F D H Y +L G+NL ++ + V +VG +G GKS+ + RL +P G
Sbjct: 392 GNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEG 451
Query: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFN---------LDPFDRHTDQ--- 1245
I IDG DI + + LR + V+ Q+PVL S TI N +D + +
Sbjct: 452 TINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANA 511
Query: 1246 --------QIWDAL-------------ERTFLTKA------IILIDEATASIDMETDTLI 1278
Q +D L +R + +A I+L+DEAT+++D E++ +
Sbjct: 512 YEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV 571
Query: 1279 QRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAAL-MA 1337
Q + +A +G T +VIAHR++TV N D I +G +VE L KK G F + M
Sbjct: 572 QAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQ 631
Query: 1338 TATSSLR 1344
T+ S ++
Sbjct: 632 TSGSQIQ 638
Score = 94.0 bits (232), Expect = 9e-19
Identities = 70/251 (27%), Positives = 124/251 (49%), Gaps = 51/251 (20%)
Query: 1139 GEIIFQDYHMKY--RDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMA 1196
G I F + Y R N P VL G++L ++ + + +VG +G GKS++ L R +P+A
Sbjct: 1032 GNITFNEVVFNYPTRANVP-VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLA 1090
Query: 1197 GRI-------LIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIR---------------- 1233
G + L+DG + + ++ LR++L ++ Q+P+L +I
Sbjct: 1091 GTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDE 1150
Query: 1234 -------FNLDPF-------------DRHTD----QQIWDALERTFLTKA-IILIDEATA 1268
N+ PF D+ T Q+ A+ R + + I+L+DEAT+
Sbjct: 1151 IVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATS 1210
Query: 1269 SIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKP 1328
++D E++ ++Q + +A +G T +VIAHR++T+ N D I+V NG+V E + L +
Sbjct: 1211 ALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQK 1270
Query: 1329 GSLFAALMATA 1339
G F+ + A
Sbjct: 1271 GIYFSMVSVQA 1281
>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
sapiens]
Length = 738
Score = 110 bits (274), Expect = 1e-23
Identities = 72/229 (31%), Positives = 122/229 (53%), Gaps = 25/229 (10%)
Query: 525 PELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG------------ 572
P +L + G + + G +GSGKS++LS +L G++ + G
Sbjct: 508 PIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLR 567
Query: 573 -SLAYVPQQAWIVSGNIRENILMGG-------AYDKARYLQVLHCCSLNRDLELLPFGDM 624
+ V Q+ + S +I ENI G A + R +V + + R+ P G
Sbjct: 568 SKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNF---PQGFN 624
Query: 625 TEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGK 684
T +GE+G+ LSGGQKQRI++ARA+ + +I LLD+ SA+DA +++ +E + + + G+
Sbjct: 625 TVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAE-NEYLVQEALDRLMDGR 683
Query: 685 TVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQK-KGKYAQLIQK 732
TV+++ H+L ++ + +L+ GKI E G H EL+ K G Y +L+ K
Sbjct: 684 TVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNK 732
Score = 109 bits (273), Expect = 2e-23
Identities = 130/557 (23%), Positives = 236/557 (42%), Gaps = 88/557 (15%)
Query: 850 LGNIAD----NPQLSFY----QLVYGLNALLLICVGVCSSGIFTKVT--RKASTALHNKL 899
LG I D NP + + +L GL+A+ L + ++ T ++ L L
Sbjct: 192 LGKIIDVIYTNPTVDYSDNLTRLCLGLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSL 251
Query: 900 FNKVFRCPMSFFDTIPIGRLLNCFAGDL--------EQLDQLLPIFSEQFLVLSLMVIAV 951
F+ + R ++FFD G L+N + D E L L ++ + +S+M
Sbjct: 252 FSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMM---- 307
Query: 952 LLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSS 1011
+ L+ ++L + + +I IY +K V + ++ +++ + + + +
Sbjct: 308 FFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQ--DSLAQATQLAE--ERIGNVRT 363
Query: 1012 IHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISS 1071
+ +GK I ++ D + + NL+ L+V + S
Sbjct: 364 VRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGS 423
Query: 1072 TPY------SFKVMA--VNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAP 1123
SF + A V I + SSF + GL + E + + K+ +E
Sbjct: 424 AHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLW--ELLEREPKLPFNEGV 481
Query: 1124 LHMEGTSCPQGWPQHGEIIFQDYHMKY--RDNTPTVLHGINLTIRGHEVVGIVGRTGSGK 1181
+ E + G + F++ H Y R P + +L+I V +VG +GSGK
Sbjct: 482 ILNEKSF-------QGALEFKNVHFAYPARPEVP-IFQDFSLSIPSGSVTALVGPSGSGK 533
Query: 1182 SSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNL----- 1236
S++ L RL +P +G I +DG DI + LRSK+ + Q+P+L S +I N+
Sbjct: 534 STVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGAD 593
Query: 1237 DPFDRHTDQ-----QIWDAL--------------------------ERTFLTKA------ 1259
DP ++ ++ +A+ +R + +A
Sbjct: 594 DPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPK 653
Query: 1260 IILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFD 1319
I+L+DEAT+++D E + L+Q + G TVLVIAHR++T+ N + + V+ GK+ E+
Sbjct: 654 ILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYG 713
Query: 1320 RPEVLRKKPGSLFAALM 1336
+ E L KP ++ LM
Sbjct: 714 KHEELLSKPNGIYRKLM 730
>gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo
sapiens]
Length = 812
Score = 105 bits (262), Expect = 3e-22
Identities = 68/223 (30%), Positives = 119/223 (53%), Gaps = 23/223 (10%)
Query: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
L ++L + +G + G++G GKS+ + + ++G V G
Sbjct: 588 LRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQ 647
Query: 574 LAYVPQQAWIVSGNIRENILMGGAYDKARYL------QVLHCCSLNRDLELLPFGDMTEI 627
+A VPQ+ + + +I ENI G D +R + + + +++ +E LP T++
Sbjct: 648 IAIVPQEPVLFNCSIAENIAYG---DNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQV 704
Query: 628 GERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVV 687
G +G LSGGQKQR+++ARA+ +I LLD+ SA+D K + + + K G+T +
Sbjct: 705 GLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEK-VVQHALDKARTGRTCL 763
Query: 688 LVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730
+VTH+L ++ I++L NGKI E GTH EL++ + Y +L+
Sbjct: 764 VVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLV 806
Score = 96.3 bits (238), Expect = 2e-19
Identities = 61/202 (30%), Positives = 106/202 (52%), Gaps = 41/202 (20%)
Query: 1157 VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRS 1216
+L G++L+I + V VG +G GKS+ L RL +P+ G++L DGVD + ++ LRS
Sbjct: 587 ILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRS 646
Query: 1217 KLSVIPQDPVLLSGTIRFNLD--------PFDRHTD------------------------ 1244
+++++PQ+PVL + +I N+ P D +
Sbjct: 647 QIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGL 706
Query: 1245 --------QQIWDALERTFLTK-AIILIDEATASIDMETDTLIQRTIREAFQGCTVLVIA 1295
Q+ A+ R L K I+L+DEAT+++D +++ ++Q + +A G T LV+
Sbjct: 707 KGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVT 766
Query: 1296 HRVTTVLNCDHILVMGNGKVVE 1317
HR++ + N D I+V+ NGK+ E
Sbjct: 767 HRLSAIQNADLIVVLHNGKIKE 788
Score = 89.0 bits (219), Expect = 3e-17
Identities = 52/153 (33%), Positives = 87/153 (56%), Gaps = 17/153 (11%)
Query: 625 TEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGK 684
T +GE+G +SGGQKQRI++ARA+ + +I +LD+ SA+D+ K + ++K +G+
Sbjct: 71 TLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSE-SKSAVQAALEKASKGR 129
Query: 685 TVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQD 744
T ++V H+L + I+ L++G + E G H+ELM K+G Y L+ M QD
Sbjct: 130 TTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLV----------MSQD 179
Query: 745 TAKIAEKPKVESQALATSLEESLNGNAVPEHQL 777
K E ++ES +T + N++P H +
Sbjct: 180 IKKADE--QMESMTYSTERKT----NSLPLHSV 206
Score = 57.8 bits (138), Expect = 7e-08
Identities = 40/177 (22%), Positives = 80/177 (45%), Gaps = 39/177 (22%)
Query: 1200 LIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNL-----DPFDRHTDQQIWDALERT 1254
++D DI ++ + R + V+ Q+PVL TI N+ D D ++ +A
Sbjct: 1 MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYD 60
Query: 1255 FLTK----------------------------------AIILIDEATASIDMETDTLIQR 1280
F+ + I+++DEAT+++D E+ + +Q
Sbjct: 61 FIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQA 120
Query: 1281 TIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMA 1337
+ +A +G T +V+AHR++T+ + D I+ + +G + E L K G ++ +M+
Sbjct: 121 ALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMS 177
>gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo
sapiens]
Length = 753
Score = 105 bits (262), Expect = 3e-22
Identities = 76/248 (30%), Positives = 119/248 (47%), Gaps = 40/248 (16%)
Query: 1136 PQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPM 1195
PQ + F + H +Y + VL GI+ + + V IVG +GSGKS++ LFR EP
Sbjct: 468 PQTATVAFDNVHFEYIEGQK-VLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQ 526
Query: 1196 AGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNL-------DPFDRHT----- 1243
G I + G +I + LE LR + V+PQD VL TI +NL P + +
Sbjct: 527 KGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLA 586
Query: 1244 -------------DQQIWD-------------ALERTFL-TKAIILIDEATASIDMETDT 1276
D Q+ + A+ R L +IL DEAT+S+D T+
Sbjct: 587 GLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEE 646
Query: 1277 LIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALM 1336
I +++ + T + IAHR++TV++ D I+V+ GKV E L P S+++ +
Sbjct: 647 TILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMW 706
Query: 1337 ATATSSLR 1344
T +S ++
Sbjct: 707 HTQSSRVQ 714
Score = 99.0 bits (245), Expect = 3e-20
Identities = 67/256 (26%), Positives = 124/256 (48%), Gaps = 18/256 (7%)
Query: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
L I+ V G + + G +GSGKS+++ + +GS+ + G +
Sbjct: 489 LSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRA 548
Query: 574 LAYVPQQAWIVSGNIRENILMGG-AYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGL 632
+ VPQ A + I N+L G + V L+ + +P G T++GERGL
Sbjct: 549 VGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGL 608
Query: 633 NLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQ 692
LSGG+KQR+++ARA+ D + L D+ S++D+ + + +K ++ +T + + H+
Sbjct: 609 KLSGGEKQRVAIARAILKDPPVILYDEATSSLDS-ITEETILGAMKDVVKHRTSIFIAHR 667
Query: 693 LQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAK-IAEK 751
L + +II+L+ GK+ E GTH L+ ++ + H +++ D K A+K
Sbjct: 668 LSTVVDADEIIVLDQGKVAERGTHHGLL--ANPHSIYSEMWHTQSSRVQNHDNPKWEAKK 725
Query: 752 PKVESQALATSLEESL 767
+ + L+E +
Sbjct: 726 ENISKEEERKKLQEEI 741
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.138 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,663,243
Number of Sequences: 37866
Number of extensions: 2031132
Number of successful extensions: 8227
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 75
Number of HSP's successfully gapped in prelim test: 38
Number of HSP's that attempted gapping in prelim test: 7625
Number of HSP's gapped (non-prelim): 388
length of query: 1344
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1230
effective length of database: 13,930,794
effective search space: 17134876620
effective search space used: 17134876620
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.