BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|21729876 ATP-binding cassette, sub-family C, member 11 isoform b [Homo sapiens] (1344 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|21729876 ATP-binding cassette, sub-family C, member 11 isofor... 2654 0.0 gi|21729873 ATP-binding cassette, sub-family C, member 11 isofor... 2635 0.0 gi|15149474 ATP-binding cassette, sub-family C, member 11 isofor... 2635 0.0 gi|89111135 ATP-binding cassette protein C12 [Homo sapiens] 1203 0.0 gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform... 949 0.0 gi|157502201 ATP-binding cassette, sub-family C, member 4 isofor... 640 0.0 gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform ... 620 e-177 gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member... 591 e-168 gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor... 588 e-167 gi|134142335 ATP-binding cassette, sub-family C, member 1 isofor... 537 e-152 gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo ... 524 e-148 gi|190343023 ATP-binding cassette, sub-family C, member 6 isofor... 519 e-147 gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo ... 518 e-146 gi|239756495 PREDICTED: hypothetical protein [Homo sapiens] 518 e-146 gi|110832837 ATP-binding cassette, sub-family C, member 9 isofor... 510 e-144 gi|110832839 ATP-binding cassette, sub-family C, member 9 isofor... 502 e-141 gi|110832835 ATP-binding cassette, sub-family C, member 9 isofor... 500 e-141 gi|134142345 ATP-binding cassette, sub-family C, member 1 isofor... 470 e-132 gi|134142340 ATP-binding cassette, sub-family C, member 1 isofor... 423 e-118 gi|157502203 ATP-binding cassette, sub-family C, member 4 isofor... 391 e-108 gi|134142342 ATP-binding cassette, sub-family C, member 1 isofor... 347 6e-95 gi|90421313 cystic fibrosis transmembrane conductance regulator ... 250 6e-66 gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 179 1e-44 gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 167 5e-41 gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C... 114 6e-25 gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A... 114 6e-25 gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B... 111 5e-24 gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo... 110 1e-23 gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo ... 105 3e-22 gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo s... 105 3e-22 >gi|21729876 ATP-binding cassette, sub-family C, member 11 isoform b [Homo sapiens] Length = 1344 Score = 2654 bits (6878), Expect = 0.0 Identities = 1344/1344 (100%), Positives = 1344/1344 (100%) Query: 1 MTRKRTYWVPNSSGGLVNRGIDIGDDMVSGLIYKTYTLQDGPWSQQERNPEAPGRAAVPP 60 MTRKRTYWVPNSSGGLVNRGIDIGDDMVSGLIYKTYTLQDGPWSQQERNPEAPGRAAVPP Sbjct: 1 MTRKRTYWVPNSSGGLVNRGIDIGDDMVSGLIYKTYTLQDGPWSQQERNPEAPGRAAVPP 60 Query: 61 WGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPL 120 WGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPL Sbjct: 61 WGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPL 120 Query: 121 SVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLG 180 SVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLG Sbjct: 121 SVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLG 180 Query: 181 PILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSS 240 PILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSS Sbjct: 181 PILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSS 240 Query: 241 FAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIG 300 FAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIG Sbjct: 241 FAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIG 300 Query: 301 YTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKP 360 YTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKP Sbjct: 301 YTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKP 360 Query: 361 FAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSM 420 FAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSM Sbjct: 361 FAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSM 420 Query: 421 LASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEAT 480 LASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEAT Sbjct: 421 LASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEAT 480 Query: 481 LSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMML 540 LSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMML Sbjct: 481 LSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMML 540 Query: 541 GVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDK 600 GVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDK Sbjct: 541 GVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDK 600 Query: 601 ARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDP 660 ARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDP Sbjct: 601 ARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDP 660 Query: 661 LSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELM 720 LSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELM Sbjct: 661 LSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELM 720 Query: 721 QKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEESLNGNAVPEHQLTQE 780 QKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEESLNGNAVPEHQLTQE Sbjct: 721 QKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEESLNGNAVPEHQLTQE 780 Query: 781 EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSS 840 EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSS Sbjct: 781 EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSS 840 Query: 841 RESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLF 900 RESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLF Sbjct: 841 RESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLF 900 Query: 901 NKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSP 960 NKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSP Sbjct: 901 NKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSP 960 Query: 961 YILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTED 1020 YILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTED Sbjct: 961 YILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTED 1020 Query: 1021 FISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMA 1080 FISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMA Sbjct: 1021 FISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMA 1080 Query: 1081 VNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGE 1140 VNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGE Sbjct: 1081 VNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGE 1140 Query: 1141 IIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRIL 1200 IIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRIL Sbjct: 1141 IIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRIL 1200 Query: 1201 IDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAI 1260 IDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAI Sbjct: 1201 IDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAI 1260 Query: 1261 ILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDR 1320 ILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDR Sbjct: 1261 ILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDR 1320 Query: 1321 PEVLRKKPGSLFAALMATATSSLR 1344 PEVLRKKPGSLFAALMATATSSLR Sbjct: 1321 PEVLRKKPGSLFAALMATATSSLR 1344 >gi|21729873 ATP-binding cassette, sub-family C, member 11 isoform a [Homo sapiens] Length = 1382 Score = 2635 bits (6829), Expect = 0.0 Identities = 1344/1382 (97%), Positives = 1344/1382 (97%), Gaps = 38/1382 (2%) Query: 1 MTRKRTYWVPNSSGGLVNRGIDIGDDMVSGLIYKTYTLQDGPWSQQERNPEAPGRAAVPP 60 MTRKRTYWVPNSSGGLVNRGIDIGDDMVSGLIYKTYTLQDGPWSQQERNPEAPGRAAVPP Sbjct: 1 MTRKRTYWVPNSSGGLVNRGIDIGDDMVSGLIYKTYTLQDGPWSQQERNPEAPGRAAVPP 60 Query: 61 WGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPL 120 WGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPL Sbjct: 61 WGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPL 120 Query: 121 SVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLG 180 SVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLG Sbjct: 121 SVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLG 180 Query: 181 PILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSS 240 PILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSS Sbjct: 181 PILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSS 240 Query: 241 FAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIG 300 FAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIG Sbjct: 241 FAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIG 300 Query: 301 YTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKP 360 YTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKP Sbjct: 301 YTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKP 360 Query: 361 FAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSM 420 FAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSM Sbjct: 361 FAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSM 420 Query: 421 LASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEAT 480 LASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEAT Sbjct: 421 LASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEAT 480 Query: 481 LSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMML 540 LSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMML Sbjct: 481 LSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMML 540 Query: 541 GVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDK 600 GVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDK Sbjct: 541 GVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDK 600 Query: 601 ARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDP 660 ARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDP Sbjct: 601 ARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDP 660 Query: 661 LSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELM 720 LSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELM Sbjct: 661 LSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELM 720 Query: 721 QKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEESLNGNAVPEHQLTQE 780 QKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEESLNGNAVPEHQLTQE Sbjct: 721 QKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEESLNGNAVPEHQLTQE 780 Query: 781 EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSS 840 EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSS Sbjct: 781 EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSS 840 Query: 841 RESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLF 900 RESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLF Sbjct: 841 RESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLF 900 Query: 901 NKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSP 960 NKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSP Sbjct: 901 NKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSP 960 Query: 961 YILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTED 1020 YILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTED Sbjct: 961 YILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTED 1020 Query: 1021 FISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMA 1080 FISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMA Sbjct: 1021 FISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMA 1080 Query: 1081 VNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGE 1140 VNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGE Sbjct: 1081 VNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGE 1140 Query: 1141 IIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRIL 1200 IIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRIL Sbjct: 1141 IIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRIL 1200 Query: 1201 IDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKA- 1259 IDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKA Sbjct: 1201 IDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAI 1260 Query: 1260 -------------------------------------IILIDEATASIDMETDTLIQRTI 1282 IILIDEATASIDMETDTLIQRTI Sbjct: 1261 SKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTLIQRTI 1320 Query: 1283 REAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATATSS 1342 REAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATATSS Sbjct: 1321 REAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATATSS 1380 Query: 1343 LR 1344 LR Sbjct: 1381 LR 1382 >gi|15149474 ATP-binding cassette, sub-family C, member 11 isoform a [Homo sapiens] Length = 1382 Score = 2635 bits (6829), Expect = 0.0 Identities = 1344/1382 (97%), Positives = 1344/1382 (97%), Gaps = 38/1382 (2%) Query: 1 MTRKRTYWVPNSSGGLVNRGIDIGDDMVSGLIYKTYTLQDGPWSQQERNPEAPGRAAVPP 60 MTRKRTYWVPNSSGGLVNRGIDIGDDMVSGLIYKTYTLQDGPWSQQERNPEAPGRAAVPP Sbjct: 1 MTRKRTYWVPNSSGGLVNRGIDIGDDMVSGLIYKTYTLQDGPWSQQERNPEAPGRAAVPP 60 Query: 61 WGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPL 120 WGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPL Sbjct: 61 WGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPL 120 Query: 121 SVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLG 180 SVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLG Sbjct: 121 SVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLG 180 Query: 181 PILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSS 240 PILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSS Sbjct: 181 PILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSS 240 Query: 241 FAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIG 300 FAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIG Sbjct: 241 FAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIG 300 Query: 301 YTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKP 360 YTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKP Sbjct: 301 YTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKP 360 Query: 361 FAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSM 420 FAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSM Sbjct: 361 FAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSM 420 Query: 421 LASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEAT 480 LASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEAT Sbjct: 421 LASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEAT 480 Query: 481 LSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMML 540 LSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMML Sbjct: 481 LSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMML 540 Query: 541 GVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDK 600 GVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDK Sbjct: 541 GVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDK 600 Query: 601 ARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDP 660 ARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDP Sbjct: 601 ARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDP 660 Query: 661 LSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELM 720 LSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELM Sbjct: 661 LSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELM 720 Query: 721 QKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEESLNGNAVPEHQLTQE 780 QKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEESLNGNAVPEHQLTQE Sbjct: 721 QKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEESLNGNAVPEHQLTQE 780 Query: 781 EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSS 840 EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSS Sbjct: 781 EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSS 840 Query: 841 RESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLF 900 RESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLF Sbjct: 841 RESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLF 900 Query: 901 NKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSP 960 NKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSP Sbjct: 901 NKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSP 960 Query: 961 YILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTED 1020 YILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTED Sbjct: 961 YILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTED 1020 Query: 1021 FISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMA 1080 FISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMA Sbjct: 1021 FISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMA 1080 Query: 1081 VNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGE 1140 VNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGE Sbjct: 1081 VNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGE 1140 Query: 1141 IIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRIL 1200 IIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRIL Sbjct: 1141 IIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRIL 1200 Query: 1201 IDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKA- 1259 IDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKA Sbjct: 1201 IDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAI 1260 Query: 1260 -------------------------------------IILIDEATASIDMETDTLIQRTI 1282 IILIDEATASIDMETDTLIQRTI Sbjct: 1261 SKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTLIQRTI 1320 Query: 1283 REAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATATSS 1342 REAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATATSS Sbjct: 1321 REAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATATSS 1380 Query: 1343 LR 1344 LR Sbjct: 1381 LR 1382 >gi|89111135 ATP-binding cassette protein C12 [Homo sapiens] Length = 1359 Score = 1203 bits (3112), Expect = 0.0 Identities = 622/1342 (46%), Positives = 862/1342 (64%), Gaps = 78/1342 (5%) Query: 63 KYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSV 122 +YD +L+TMIP RP R AP P+D+AGL S+ T SWLTP+M++ R RL +T+PPLS Sbjct: 24 RYDPSLKTMIPVRPCARL-APNPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLST 82 Query: 123 HDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLGPI 182 +D+SD N +R LW+EEV+R G EKAS+ V+ +FQRTR++ D + I I + +GP+ Sbjct: 83 YDSSDTNAKRFRVLWDEEVARVGPEKASLSHVVWKFQRTRVLMDIVANILCIIMAAIGPV 142 Query: 183 LIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSSFA 242 ++I +IL+ +E G V G+GLC ALF +E K ++ +W IN RTAIR + A+S+ Sbjct: 143 ILIHQILQQTERTSGKVWVGIGLCIALFATEFTKVFFWALAWAINYRTAIRLKVALSTLV 202 Query: 243 FEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIGYT 302 FE L+ FK++ HI+ GE ++ + D LFE + PL +V C+ ++FI+G T Sbjct: 203 FENLVSFKTLTHISVGEVLNILSSDSYSLFEAALFCPLPATIPILMVFCAAYAFFILGPT 262 Query: 303 AFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFA 362 A I I Y++ P+ +FM ++ + V+D+R++ +E LTCI+LIKMY WEK F Sbjct: 263 ALIGISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAWEKSFT 322 Query: 363 KIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLA 422 I+D+RR+ERKLLEK G VQS S I+ T+A + + H L+ KLTA +AFS++A Sbjct: 323 NTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTLSCHILLRRKLTAPVAFSVIA 382 Query: 423 SLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEATLS 482 N+++ S+ +P ++K + + ++ R KK + +SP Y+ +DP L+ ATL+ Sbjct: 383 MFNVMKFSIAILPFSIKAMAEANVSLRRMKKILIDKSPPSYITQPEDPDTVLLLANATLT 442 Query: 483 WQ------QTCPGIVNGALEL---ERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLV 533 W+ T + N L +R+ SE + A GPEE+ +SL LH I+ V Sbjct: 443 WEHEASRKSTPKKLQNQKRHLCKKQRSEAYSERSPPAKGATGPEEQSDSLKSVLHSISFV 502 Query: 534 VSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENIL 593 V KG +LG+CGN GSGKSSLL+A+L +M L +G V V G+LAYV QQAWI GN+RENIL Sbjct: 503 VRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGTLAYVSQQAWIFHGNVRENIL 562 Query: 594 MGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQ 653 G YD RY + C L +DL LP+GD+TEIGERGLNLSGGQ+QRISLARAVYSDRQ Sbjct: 563 FGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERGLNLSGGQRQRISLARAVYSDRQ 622 Query: 654 IYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICEN 713 +YLLDDPLSAVDAHVGKH+FEECIKKTLRGKTVVLVTHQLQ+LE C ++ILLE+G+ICE Sbjct: 623 LYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTHQLQFLESCDEVILLEDGEICEK 682 Query: 714 GTHSELMQKKGKYAQLIQKMH-------------------KEATSDMLQDTAKIAEKPKV 754 GTH ELM+++G+YA+LI + KE+ ++ +D I P Sbjct: 683 GTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNAAMVEAFKESPAEREEDAGIIVLAPGN 742 Query: 755 E-SQALATSLEESLNGNAVPEHQLTQEEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFV 813 E + + VPEHQL Q E +EG+++W+ YH YI+A+GGY++S F Sbjct: 743 EKDEGKESETGSEFVDTKVPEHQLIQTESPQEGTVTWKTYHTYIKASGGYLLSLFTVFLF 802 Query: 814 VLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLL 873 +L++ FS WWL WL++GS + N TM ++G + + YQ VY + + + Sbjct: 803 LLMIGSAAFSNWWLGLWLDKGSRMTCGPQGNRTMCEVGAVLADIGQHVYQWVYTASMVFM 862 Query: 874 ICVGVCSSGIFTKVTRKASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQL 933 + GV +FTK T AS++LH+ +F+K+ + PMSFFDT P GRL+N F+ D+++LD Sbjct: 863 LVFGVTKGFVFTKTTLMASSSLHDTVFDKILKSPMSFFDTTPTGRLMNRFSKDMDELDVR 922 Query: 934 LPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENY 993 LP +E FL MV+ +L+I++ + P +LL+ A + V FI +F + + K++EN Sbjct: 923 LPFHAENFLQQFFMVVFILVILAAVFPAVLLVVASLAVGFFILLRIFHRGVQELKKVENV 982 Query: 994 SRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIM 1053 SRSP F+HI +S+QGL IH YGK E I+ +LL F + RW ALR++++ Sbjct: 983 SRSPWFTHITSSMQGLGIIHAYGKKESCITY----------HLLYFNCALRWFALRMDVL 1032 Query: 1054 TNLVTLAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQ 1113 N++T VAL V SS S K ++++ ++QL+ Q R G ET+A+FT+VE + + Sbjct: 1033 MNILTFTVALLVTLSFSSISTSSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLRE 1092 Query: 1114 YMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGI 1173 Y+ CV E ++ +CP+ WP GEI F+DY M+YRDNTP VL +NL I+ + VGI Sbjct: 1093 YISTCVPECTHPLKVGTCPKDWPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGI 1152 Query: 1174 VGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIR 1233 VGRTGSGKSSLGMALFRLVEP +G I ID VDIC + LEDLR+KL+VIPQDPVL GT+R Sbjct: 1153 VGRTGSGKSSLGMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVR 1212 Query: 1234 FNLDPFDRHTDQQIWDALERTFL------------------------------------- 1256 +NLDPF+ HTD+ +W LERTF+ Sbjct: 1213 YNLDPFESHTDEMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALL 1272 Query: 1257 -TKAIILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKV 1315 IIL+DEATAS+D +TDTL+Q TI++AF+GCTVL IAHR+ TVLNCDH+LVM NGKV Sbjct: 1273 RNSKIILLDEATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKV 1332 Query: 1316 VEFDRPEVLRKKPGSLFAALMA 1337 +EFD+PEVL +KP S FA L+A Sbjct: 1333 IEFDKPEVLAEKPDSAFAMLLA 1354 >gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform 1 [Homo sapiens] Length = 1437 Score = 949 bits (2453), Expect = 0.0 Identities = 528/1360 (38%), Positives = 785/1360 (57%), Gaps = 79/1360 (5%) Query: 60 PWGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLM-IQSLRSRLDENTIP 118 P GKY L + P R + P+DNAGLFS +T SWL+ L + + L + Sbjct: 77 PKGKYHHGLSALKPIRTTSKHQ--HPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVW 134 Query: 119 PLSVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASV 178 LS H++SD N +RL RLW+EE++ G + AS+ V+ F RTRLI + + +A Sbjct: 135 SLSKHESSDVNCRRLERLWQEELNEVGPDAASLRRVVWIFCRTRLILSIVCLMITQLAGF 194 Query: 179 LGPILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAV 238 GP ++ +LEY++ N+ + + L L L+E V+S S + +W +N RT +R R A+ Sbjct: 195 SGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTWALNYRTGVRLRGAI 254 Query: 239 SSFAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFI 298 + AF+K+++ K++ + GE I+ + D +FE G L+ ++ I + I Sbjct: 255 LTMAFKKILKLKNIKEKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVII 314 Query: 299 IGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWE 358 +G T F+ ++L +P +F +R+ + +D+R++ +EVLT IK IKMY W Sbjct: 315 LGPTGFLGSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWV 374 Query: 359 KPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAF 418 K F++ ++ +R +ER++LEK G QS+T I+ +A+ V +H +L LTA+ AF Sbjct: 375 KAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAF 434 Query: 419 SMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEE 478 +++ N + ++ P +VK L+ + AV RFK FL E P + + Sbjct: 435 TVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKN 494 Query: 479 ATLSWQQTCPGIVNGAL---ELERNGHASEGMTRP--------RDALGPEEEGNSL---- 523 ATL+W + I N +++++ AS G A+ E++G+ L Sbjct: 495 ATLAWDSSHSSIQNSPKLTPKMKKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHLLLDSD 554 Query: 524 ---GPE-----------------LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHL 563 PE LH I+L + +G ++G+CG+ GSGK+SL+SAIL +M L Sbjct: 555 ERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTL 614 Query: 564 LEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGD 623 LEGS+ + G+ AYV QQAWI++ +R+NIL G YD+ RY VL+ C L DL +LP D Sbjct: 615 LEGSIAISGTFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSD 674 Query: 624 MTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRG 683 +TEIGERG NLSGGQ+QRISLARA+YSDR IY+LDDPLSA+DAHVG HIF I+K L+ Sbjct: 675 LTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKS 734 Query: 684 KTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQ 743 KTV+ VTHQLQYL C ++I ++ G I E GTH ELM G YA + + T + Sbjct: 735 KTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGETPPVEI 794 Query: 744 DTAKIAEKPKVESQALATSLEESLNGNAVP--EHQLTQEEEMEEGSLSWRVYHHYIQAAG 801 ++ K + +SQ AV E QL Q EE +GS+ W VY YIQAAG Sbjct: 795 NSKKETSGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQGSVPWSVYGVYIQAAG 854 Query: 802 GYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSF 861 G + +I +L V T FS WWLSYW++QGSG + N T ++ DNP + + Sbjct: 855 GPLAFLVIMALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETSVS-DSMKDNPHMQY 913 Query: 862 YQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLFNKVFRCPMSFFDTIPIGRLLN 921 Y +Y L+ +++ + +F K T +AS+ LH++LF ++ R PM FFDT P GR+LN Sbjct: 914 YASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILN 973 Query: 922 CFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFK 981 F+ D++++D LP +E F+ ++V + +++ + P+ L+ ++++ + +++ + Sbjct: 974 RFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSR 1033 Query: 982 KAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLS 1041 I KRL+N ++SP SHI +S+QGL++IH Y K ++F+ +++ L D LF Sbjct: 1034 VLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTC 1093 Query: 1042 STRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLET 1101 + RW+A+RL++++ + L + P ++ +A++ +QL FQ T R+ ET Sbjct: 1094 AMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLASET 1153 Query: 1102 EAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGI 1161 EA+FT+VERI Y+K EAP ++ + WPQ GE+ F++ M+YR+N P VL + Sbjct: 1154 EARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVLKKV 1213 Query: 1162 NLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVI 1221 + TI+ E +GIVGRTGSGKSSLGMALFRLVE G I IDGV I IGL DLRSKLS+I Sbjct: 1214 SFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSII 1273 Query: 1222 PQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKA---------------------- 1259 PQ+PVL SGT+R NLDPF+++T+ QIWDALERT + + Sbjct: 1274 PQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVG 1333 Query: 1260 ----------------IILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLN 1303 I+++DEATA++D ETD LIQ TIREAF CT+L IAHR+ TVL Sbjct: 1334 ERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLG 1393 Query: 1304 CDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATATSSL 1343 D I+V+ G+VVEFD P VL S F A+ A A + + Sbjct: 1394 SDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAAAENKV 1433 >gi|157502201 ATP-binding cassette, sub-family C, member 4 isoform 1 [Homo sapiens] Length = 1325 Score = 640 bits (1651), Expect = 0.0 Identities = 433/1317 (32%), Positives = 669/1317 (50%), Gaps = 124/1317 (9%) Query: 83 PQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEEVS 142 P PL +A L S + WL PL + RL+E+ + + D S + L W++EV Sbjct: 10 PNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVL 69 Query: 143 R--RGIEKASVLLVMLR-FQRTRLIFDALLGICFCI---ASVLGPILIIPKILEYSE--E 194 R +K S+ +++ + ++ L+ LGI I A V+ PI + KI+ Y E + Sbjct: 70 RAENDAQKPSLTRAIIKCYWKSYLV----LGIFTLIEESAKVIQPIFL-GKIINYFENYD 124 Query: 195 QLGNVVHGVGLCFALFLSECVKSLSFSSSWIIN--QRTAIRFRAAVSSFAFEKLIQFKSV 252 + +V +A L+ C L+ Q +R R A+ + K ++ ++ Sbjct: 125 PMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNM 184 Query: 253 I--HITSGEAISFFTGDVNYLFEGVCY------GPLVLITCASLVICSISSYFIIGYTAF 304 T+G+ ++ + DVN + + GPL I +L+ + IG + Sbjct: 185 AMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALL------WMEIGISCL 238 Query: 305 IAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKI 364 + +++ PL ++ + T+ +D RIR +EV+T I++IKMY WEK F+ + Sbjct: 239 AGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNL 298 Query: 365 IEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLASL 424 I +LR+KE + + ++ + + F + V + L +TAS F + Sbjct: 299 ITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLY 358 Query: 425 NLLRLSV-FFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVF-EEATLS 482 +RL+V F P A++ ++ + ++ R + F L + + L K +V ++ T Sbjct: 359 GAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAF 418 Query: 483 WQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLGV 542 W + ASE P L ++ V G +L V Sbjct: 419 WDK-----------------ASET------------------PTLQGLSFTVRPGELLAV 443 Query: 543 CGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKAR 602 G G+GKSSLLSA+L E+ G V V G +AYV QQ W+ SG +R NIL G Y+K R Sbjct: 444 VGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKER 503 Query: 603 YLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLS 662 Y +V+ C+L +DL+LL GD+T IG+RG LSGGQK R++LARAVY D IYLLDDPLS Sbjct: 504 YEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLS 563 Query: 663 AVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQK 722 AVDA V +H+FE CI + L K +LVTHQLQYL+ QI++L++GK+ + GT++E ++ Sbjct: 564 AVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKS 623 Query: 723 KGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALA-TSLEESLNGNAVPEHQLTQ-- 779 + L++K ++E+ + T + + ES + S SL A+ E Q T+ Sbjct: 624 GIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGAL-ESQDTENV 682 Query: 780 -----EEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQG 834 EE EG + ++ Y +Y +A ++V + + WWLSYW Sbjct: 683 PVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYW---- 738 Query: 835 SGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTA 894 N N T+ GN+ + L++Y +Y + + G+ S + V +S Sbjct: 739 --ANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQT 796 Query: 895 LHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLI 954 LHNK+F + + P+ FFD PIGR+LN F+ D+ LD LLP+ F+ L V+ V+ + Sbjct: 797 LHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSV 856 Query: 955 VSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHV 1014 + P+I + + +I F + KRLE+ +RSP+FSH+ +SLQGL +I Sbjct: 857 AVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRA 916 Query: 1015 YGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPY 1074 Y E F D + LFL+++RW A+RL+ + + + VA F + ++ T Sbjct: 917 YKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVA-FGSLILAKTLD 975 Query: 1075 SFKV-MAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQ 1133 + +V +A++ L L FQ R E E +VER+++Y + EAP + P Sbjct: 976 AGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDL-EKEAPWEYQKRP-PP 1033 Query: 1134 GWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVE 1193 WP G IIF + + Y P VL + I+ E VGIVGRTG+GKSSL ALFRL E Sbjct: 1034 AWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSE 1093 Query: 1194 PMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALE- 1252 P G+I ID + IGL DLR K+S+IPQ+PVL +GT+R NLDPF+ HTD+++W+AL+ Sbjct: 1094 P-EGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQE 1152 Query: 1253 ------------------------------------RTFLTK-AIILIDEATASIDMETD 1275 R L K I++IDEATA++D TD Sbjct: 1153 VQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTD 1212 Query: 1276 TLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLF 1332 LIQ+ IRE F CTVL IAHR+ T+++ D I+V+ +G++ E+D P VL + SLF Sbjct: 1213 ELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLF 1269 Score = 85.9 bits (211), Expect = 2e-16 Identities = 65/238 (27%), Positives = 119/238 (50%), Gaps = 23/238 (9%) Query: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMH---------LLEGSVGVQG---SL 574 L + ++ +G+ G TG+GKSSL+SA+ +L +G+ + Sbjct: 1058 LKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKM 1117 Query: 575 AYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNL 634 + +PQ+ + +G +R+N+ + L L +E LP TE+ E G N Sbjct: 1118 SIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNF 1177 Query: 635 SGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGK----TVVLVT 690 S GQ+Q + LARA+ QI ++D+ + VD +E I+K +R K TV+ + Sbjct: 1178 SVGQRQLVCLARAILRKNQILIIDEATANVDPRT-----DELIQKKIREKFAHCTVLTIA 1232 Query: 691 HQLQYLEFCGQIILLENGKICENGTHSELMQ-KKGKYAQLIQKMHKEATSDMLQDTAK 747 H+L + +I++L++G++ E L+Q K+ + +++Q++ K A + L +TAK Sbjct: 1233 HRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQQLGK-AEAAALTETAK 1289 >gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform 1 [Homo sapiens] Length = 1527 Score = 620 bits (1599), Expect = e-177 Identities = 442/1381 (32%), Positives = 657/1381 (47%), Gaps = 196/1381 (14%) Query: 74 FRPKPRF-------PAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDAS 126 FR KP F P P P +AG S L W T + I R L+E + L D S Sbjct: 190 FREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRS 249 Query: 127 DKNVQRLHRLWEEEVSRRGIEKAS------------VLLVMLRFQRTRLIFDALLGICFC 174 VQ+L W ++ + KAS VLL R ALL Sbjct: 250 QMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGS 309 Query: 175 IASVLGPILIIPKILEYSEEQLGNVV------------HGVGLCFALFLSECVKSLSFSS 222 + +I +L + QL +++ G + +FL ++SL Sbjct: 310 SFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQH 369 Query: 223 SWIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPL 280 + T ++FR + + K + + + S GE ++ + D + + L Sbjct: 370 YYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPF--L 427 Query: 281 VLITCASLVICSISSYFI---IGYTAFIAILCYLLVFPL----AVFMTRMAVKAQHHTSE 333 L+ A L I ++ YF+ +G + + +L+ PL AV M VK + Sbjct: 428 NLLWSAPLQII-LAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQM----K 482 Query: 334 VSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFII 393 + D RI++ SE+L IK++K+Y WE F K +E +R+ E +LL + + T+ T Sbjct: 483 LKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCS 542 Query: 394 PTVATAV--WVLIHTSLKLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRF 451 P + T + WV ++ L A AF ++ N+LRL + +P + LT + ++ R Sbjct: 543 PFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRI 602 Query: 452 KKFFLQES--PVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTR 509 ++F QE P + P A+ T +W Q P Sbjct: 603 QQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLP--------------------- 641 Query: 510 PRDALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVG 569 P LH +++ V KG ++ V G G GKSSL+SA+L EM LEG V Sbjct: 642 ---------------PTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVH 686 Query: 570 VQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGE 629 ++GS+AYVPQQAWI + ++EN+L G A + RY Q L C+L DLE+LP GD TEIGE Sbjct: 687 MKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGE 746 Query: 630 RGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECI--KKTLRGKTVV 687 +G+NLSGGQ+QR+SLARAVYSD I+LLDDPLSAVD+HV KHIF+ I + L GKT V Sbjct: 747 KGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRV 806 Query: 688 LVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDT-- 745 LVTH + +L II+L +G++ E G + L+Q+ G +A + + L+D+ Sbjct: 807 LVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWT 866 Query: 746 ----AKIAEKPKVES------------------------QALATSLEESLNGNAVPEHQL 777 A+ E +E Q A S + G VP L Sbjct: 867 ALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHL 926 Query: 778 -----------------TQEEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLT 820 TQEE+ G++ V+ Y +A G I +V Sbjct: 927 GPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLAICLLYVGQSA-AA 985 Query: 821 IFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALL--LICVGV 878 I + WLS W +N MAD + +L Y + L L L + + Sbjct: 986 IGANVWLSAW------------TNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAM 1033 Query: 879 CSSGIFTKVTRKASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFS 938 + GI +A+ LH L + R P SFFDT P GR+LNCF+ D+ +D++L Sbjct: 1034 AAGGI------QAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVI 1087 Query: 939 EQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPL 998 L I+ L+++ +P ++ + V+ + + KRLE+ SRSP+ Sbjct: 1088 LMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPI 1147 Query: 999 FSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVT 1058 +SH ++ G S I Y ++ DF DA ++ S RW+++ +E + N V Sbjct: 1148 YSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVV 1207 Query: 1059 LAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMC 1118 L ALF G SS ++V+ LQ+ + R+ + E+ AVER+ +Y K Sbjct: 1208 LFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKT- 1266 Query: 1119 VSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTG 1178 +EAP +EG+ P+GWP GE+ F++Y ++YR VL ++L + G E VGIVGRTG Sbjct: 1267 ETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTG 1326 Query: 1179 SGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDP 1238 +GKSS+ + LFR++E G I IDG+++ IGL DLRS+L++IPQDP+L SGT+R NLDP Sbjct: 1327 AGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDP 1386 Query: 1239 FDRHTDQQIWDALE-------------------------------------RTFLTKA-I 1260 F ++++ IW ALE R L K+ I Sbjct: 1387 FGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRI 1446 Query: 1261 ILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDR 1320 +++DEATA+ID+ETD LIQ TIR F CTVL IAHR+ T+++ +LV+ G V EFD Sbjct: 1447 LVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDS 1506 Query: 1321 P 1321 P Sbjct: 1507 P 1507 Score = 80.9 bits (198), Expect = 8e-15 Identities = 54/211 (25%), Positives = 100/211 (47%), Gaps = 14/211 (6%) Query: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573 L ++L V G +G+ G TG+GKSS+ + + +G + + G Sbjct: 1306 LRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQ 1365 Query: 574 LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLN 633 L +PQ + SG +R N+ G+Y + L L+ + P G + E G N Sbjct: 1366 LTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGEN 1425 Query: 634 LSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQL 693 LS GQ+Q + LARA+ +I +LD+ +A+D ++ + I+ TV+ + H+L Sbjct: 1426 LSVGQRQLVCLARALLRKSRILVLDEATAAIDLET-DNLIQATIRTQFDTCTVLTIAHRL 1484 Query: 694 QYLEFCGQIILLENGKICENGTHSELMQKKG 724 + ++++L+ G + E + + L+ +G Sbjct: 1485 NTIMDYTRVLVLDKGVVAEFDSPANLIAARG 1515 >gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 [Homo sapiens] Length = 1545 Score = 591 bits (1524), Expect = e-168 Identities = 390/1229 (31%), Positives = 625/1229 (50%), Gaps = 171/1229 (13%) Query: 209 LFLSECVKSLSFSSSWIINQRTAIRFRAAVSSFAFEKLIQFKSVIH--ITSGEAISFFTG 266 LF + ++S + + + ++ R A+ + ++K + ++ T GE ++ + Sbjct: 367 LFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLMSV 426 Query: 267 DVNYLFEGVCYGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVK 326 D L + + ++ + +V+ + +G + + +LV P+ ++ + Sbjct: 427 DAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKT 486 Query: 327 AQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLT 386 Q + D+R+++ +E+L+ IK++K + WE F +++LR+KE K L +Q + Sbjct: 487 IQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVV 546 Query: 387 ----SITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLT 442 +T ++ V +V+VL+ ++ L A AF+ + N+LR + +P+ + + Sbjct: 547 IFVFQLTPVLVSVVTFSVYVLVDSNNILD--AQKAFTSITLFNILRFPLSMLPMMISSML 604 Query: 443 NSKSAVMRFKKFF----LQESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALELE 498 + + R +K+ L S + + KA+ F EA+ +W+ Sbjct: 605 QASVSTERLEKYLGGDDLDTSAIRHDCNFD---KAMQFSEASFTWE-------------- 647 Query: 499 RNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAIL 558 H SE R +NL + G ++ V G GSGKSSL+SA+L Sbjct: 648 ---HDSEATVRD-------------------VNLDIMAGQLVAVIGPVGSGKSSLISAML 685 Query: 559 EEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLEL 618 EM + G + ++G+ AYVPQQ+WI +G I++NIL G +++ RY QVL C+L DLE+ Sbjct: 686 GEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLPDLEM 745 Query: 619 LPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIK 678 LP GD+ EIGE+G+NLSGGQKQRISLARA Y + IYLLDDPLSAVDAHVGKHIF + + Sbjct: 746 LPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLG 805 Query: 679 KT--LRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKM--- 733 L+GKT +LVTH + +L +I++L NG I E G++S L+ KKG++A+ ++ Sbjct: 806 PNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKTFLRH 865 Query: 734 ---HKEAT------------------SDMLQDTAKIAEKPKVESQALAT----------- 761 +EAT ++ +D A I + + + + Sbjct: 866 TGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAASITMRRENSFRRTLSRSSRSNGRHLK 925 Query: 762 SLEESL---NGNAVPEHQ-------LTQEEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFF 811 SL SL N N++ E + L ++E +E G + + +Y Y+QA G + + II Sbjct: 926 SLRNSLKTRNVNSLKEDEELVKGQKLIKKEFIETGKVKFSIYLEYLQAIGLFSIFFIILA 985 Query: 812 FVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNP--QLSFYQLVYGLN 869 FV+ V I S WLS W T+ S+ N T D P Q VYG Sbjct: 986 FVMNSVAF-IGSNLWLSAW------TSDSKIFNST--------DYPASQRDMRVGVYGAL 1030 Query: 870 ALLLICVGVCSSGIFTKVTR--------KASTALHNKLFNKVFRCPMSFFDTIPIGRLLN 921 L + GIF + AS LH +L N + R PM FFDT P GR++N Sbjct: 1031 GL--------AQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIVN 1082 Query: 922 CFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFK 981 FAGD+ +D LP ++ L +I+ L+++ + +P ++ + +I M + Sbjct: 1083 RFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFYV 1142 Query: 982 KAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLS 1041 +RL++ +RSP++SH ++ GL I + + F+ + D + +++ Sbjct: 1143 STSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWIT 1202 Query: 1042 STRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLET 1101 S RW+A+RLE++ NL AL + + ++ L + + R+ E Sbjct: 1203 SNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMTSEI 1262 Query: 1102 EAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGI 1161 E AVERI +Y K+ +EAP + P WP G+I F +Y ++YR VL GI Sbjct: 1263 ETNIVAVERITEYTKV-ENEAPWVTDKRP-PPDWPSKGKIQFNNYQVRYRPELDLVLRGI 1320 Query: 1162 NLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVI 1221 I E +G+VGRTG+GKSSL LFR++E G+I+IDGVDI SIGL DLR KL++I Sbjct: 1321 TCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTII 1380 Query: 1222 PQDPVLLSGTIRFNLDPFDRHTDQQIWDALE----------------------------- 1252 PQDP+L SG++R NLDPF+ ++D++IW ALE Sbjct: 1381 PQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIG 1440 Query: 1253 --------RTFLTKA-IILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLN 1303 R L K+ I+++DEATA++D+ETD LIQ TI+ F CTV+ IAHR+ T+++ Sbjct: 1441 QRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMD 1500 Query: 1304 CDHILVMGNGKVVEFDRPEVLRKKPGSLF 1332 D ++V+ NGK++E PE L + PG + Sbjct: 1501 SDKVMVLDNGKIIECGSPEELLQIPGPFY 1529 >gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1 [Homo sapiens] Length = 1531 Score = 588 bits (1516), Expect = e-167 Identities = 404/1376 (29%), Positives = 668/1376 (48%), Gaps = 180/1376 (13%) Query: 81 PAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEE 140 P P P +A S +T W+T L+++ R L+ + + L+ D S++ V L + W++E Sbjct: 205 PNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKE 264 Query: 141 VSRRGIEKASVL-----------------------LVMLRFQR--TRLIFDAL---LGIC 172 ++ + V+ L++ Q+ +F L G Sbjct: 265 CAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPY 324 Query: 173 FCIASVLGPI---------LIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSS 223 F ++ I I+ ++++ + G LF++ C+++L Sbjct: 325 FLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQY 384 Query: 224 WIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPLV 281 + I + +R + AV + K + + +S GE ++ + D + Y ++ Sbjct: 385 FHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMI 444 Query: 282 LITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRV 341 +++ + +G + + +L+ P+ M Q + D RI++ Sbjct: 445 WSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKL 504 Query: 342 TSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVW 401 +E+L IK++K+Y WE F + +R++E K+L+K + ++ + T P + Sbjct: 505 MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCT 564 Query: 402 VLIHTSLKLK--LTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQES 459 ++ ++ L A AF LA N+LR + +P+ + + + ++ R + F E Sbjct: 565 FAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEE 624 Query: 460 ---PVFYVQTLQDP--SKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRDAL 514 + ++D + ++ AT +W ++ P +NG Sbjct: 625 LEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNG--------------------- 663 Query: 515 GPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSL 574 I + +G ++ V G G GKSSLLSA+L EM +EG V ++GS+ Sbjct: 664 ---------------ITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSV 708 Query: 575 AYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNL 634 AYVPQQAWI + ++RENIL G ++ Y V+ C+L DLE+LP GD TEIGE+G+NL Sbjct: 709 AYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNL 768 Query: 635 SGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECI--KKTLRGKTVVLVTHQ 692 SGGQKQR+SLARAVYS+ IYL DDPLSAVDAHVGKHIFE I K L+ KT +LVTH Sbjct: 769 SGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHS 828 Query: 693 LQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAKIA--- 749 + YL II++ GKI E G++ EL+ + G +A+ ++ A+++ QD + Sbjct: 829 MSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTY---ASTEQEQDAEENGVTG 885 Query: 750 ------EKPKVESQALAT-----------SLEESLNGNAVPEHQLTQE------------ 780 E ++E+ L T S S +G+ H T E Sbjct: 886 VSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETW 945 Query: 781 -----EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGS 835 ++ + G + VY Y++A G ++ IF F+ V + S +WLS W + Sbjct: 946 KLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHV-SALASNYWLSLWTDDPI 1004 Query: 836 GTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTAL 895 + + ++ G + + ++ V+G + + V GI AS L Sbjct: 1005 VNGTQEHTKVRLSVYGALGISQGIA----VFGYS------MAVSIGGIL------ASRCL 1048 Query: 896 HNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIV 955 H L + + R PMSFF+ P G L+N F+ +L+ +D ++P + F+ VI +++ Sbjct: 1049 HVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVI 1108 Query: 956 SVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVY 1015 + +P ++ + +I F + + KRLE+ SRSP++SH +L G+S I + Sbjct: 1109 LLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAF 1168 Query: 1016 GKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYS 1075 + E FI Q D + + RW+A+RLE + N + L ALF S Sbjct: 1169 EEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAG 1228 Query: 1076 FKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGW 1135 ++V+ LQ+ + R+ E E AVER+ +Y + EAP ++ T+ P W Sbjct: 1229 LVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSE-TEKEAPWQIQETAPPSSW 1287 Query: 1136 PQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPM 1195 PQ G + F++Y ++YR++ VL IN+TI G E VGIVGRTG+GKSSL + LFR+ E Sbjct: 1288 PQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESA 1347 Query: 1196 AGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALE--- 1252 G I+IDG++I IGL DLR K+++IPQDPVL SG++R NLDPF +++D+++W +LE Sbjct: 1348 EGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAH 1407 Query: 1253 ----------------------------------RTFLTKA-IILIDEATASIDMETDTL 1277 R L K I+++DEATA++D+ETD L Sbjct: 1408 LKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDL 1467 Query: 1278 IQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFA 1333 IQ TIR F+ CTVL IAHR+ T+++ ++V+ G++ E+ P L ++ G ++ Sbjct: 1468 IQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYS 1523 Score = 90.9 bits (224), Expect = 7e-18 Identities = 65/224 (29%), Positives = 105/224 (46%), Gaps = 18/224 (8%) Query: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573 L IN+ ++ G +G+ G TG+GKSSL + EG + + G Sbjct: 1310 LRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFK 1369 Query: 574 LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLN 633 + +PQ + SG++R N+ Y L L + LP E E G N Sbjct: 1370 ITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGEN 1429 Query: 634 LSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQL 693 LS GQ+Q + LARA+ +I +LD+ +AVD + + I+ TV+ + H+L Sbjct: 1430 LSVGQRQLVCLARALLRKTKILVLDEATAAVDLET-DDLIQSTIRTQFEDCTVLTIAHRL 1488 Query: 694 QYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEA 737 + ++I+L+ G+I E G S+L+Q++G L M K+A Sbjct: 1489 NTIMDYTRVIVLDKGEIQEYGAPSDLLQQRG----LFYSMAKDA 1528 >gi|134142335 ATP-binding cassette, sub-family C, member 1 isoform 5 [Homo sapiens] Length = 1466 Score = 537 bits (1383), Expect = e-152 Identities = 370/1261 (29%), Positives = 613/1261 (48%), Gaps = 142/1261 (11%) Query: 81 PAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEE 140 P P P +A S +T W+T L+++ R L+ + + L+ D S++ V L + W++E Sbjct: 205 PNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKE 264 Query: 141 VSRRGIEKASVL-----------------------LVMLRFQR--TRLIFDAL---LGIC 172 ++ + V+ L++ Q+ +F L G Sbjct: 265 CAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPY 324 Query: 173 FCIASVLGPI---------LIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSS 223 F ++ I I+ ++++ + G LF++ C+++L Sbjct: 325 FLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQY 384 Query: 224 WIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPLV 281 + I + +R + AV + K + + +S GE ++ + D + Y ++ Sbjct: 385 FHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMI 444 Query: 282 LITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRV 341 +++ + +G + + +L+ P+ M Q + D RI++ Sbjct: 445 WSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKL 504 Query: 342 TSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVW 401 +E+L IK++K+Y WE F + +R++E K+L+K + ++ + T P + Sbjct: 505 MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCT 564 Query: 402 VLIHTSLKLK--LTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQES 459 ++ ++ L A AF LA N+LR + +P+ + + + ++ R + F E Sbjct: 565 FAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEE 624 Query: 460 ---PVFYVQTLQDP--SKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRDAL 514 + ++D + ++ AT +W ++ P +NG Sbjct: 625 LEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNG--------------------- 663 Query: 515 GPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSL 574 I + +G ++ V G G GKSSLLSA+L EM +EG V ++GS+ Sbjct: 664 ---------------ITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSV 708 Query: 575 AYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNL 634 AYVPQQAWI + ++RENIL G ++ Y V+ C+L DLE+LP GD TEIGE+G+NL Sbjct: 709 AYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNL 768 Query: 635 SGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECI--KKTLRGKTVVLVTHQ 692 SGGQKQR+SLARAVYS+ IYL DDPLSAVDAHVGKHIFE I K L+ KT +LVTH Sbjct: 769 SGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHS 828 Query: 693 LQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAKIA--- 749 + YL II++ GKI E G++ EL+ + G +A+ ++ A+++ QD + Sbjct: 829 MSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTY---ASTEQEQDAEENGVTG 885 Query: 750 ------EKPKVESQALAT-----------SLEESLNGNAVPEHQLTQE------------ 780 E ++E+ L T S S +G+ H T E Sbjct: 886 VSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETW 945 Query: 781 -----EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGS 835 ++ + G + VY Y++A G ++ IF F+ V + S +WLS W + Sbjct: 946 KLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHV-SALASNYWLSLWTDDPI 1004 Query: 836 GTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTAL 895 + + ++ G + + ++ V+G + + V GI AS L Sbjct: 1005 VNGTQEHTKVRLSVYGALGISQGIA----VFGYS------MAVSIGGIL------ASRCL 1048 Query: 896 HNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIV 955 H L + + R PMSFF+ P G L+N F+ +L+ +D ++P + F+ VI +++ Sbjct: 1049 HVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVI 1108 Query: 956 SVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVY 1015 + +P ++ + +I F + + KRLE+ SRSP++SH +L G+S I + Sbjct: 1109 LLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAF 1168 Query: 1016 GKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYS 1075 + E FI Q D + + RW+A+RLE + N + L ALF S Sbjct: 1169 EEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAG 1228 Query: 1076 FKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGW 1135 ++V+ LQ+ + R+ E E AVER+ +Y + EAP ++ T+ P W Sbjct: 1229 LVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSE-TEKEAPWQIQETAPPSSW 1287 Query: 1136 PQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPM 1195 PQ G + F++Y ++YR++ VL IN+TI G E VGIVGRTG+GKSSL + LFR+ E Sbjct: 1288 PQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESA 1347 Query: 1196 AGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTF 1255 G I+IDG++I IGL DLR K+++IPQDPVL SG++R NLDPF +++D+++W +LE Sbjct: 1348 EGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAH 1407 Query: 1256 L 1256 L Sbjct: 1408 L 1408 Score = 42.7 bits (99), Expect = 0.002 Identities = 32/121 (26%), Positives = 48/121 (39%), Gaps = 13/121 (10%) Query: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573 L IN+ ++ G +G+ G TG+GKSSL + EG + + G Sbjct: 1310 LRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFK 1369 Query: 574 LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLN 633 + +PQ + SG++R N+ Y L L + LP E E G N Sbjct: 1370 ITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGEN 1429 Query: 634 L 634 L Sbjct: 1430 L 1430 >gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo sapiens] Length = 1464 Score = 524 bits (1349), Expect = e-148 Identities = 412/1372 (30%), Positives = 649/1372 (47%), Gaps = 178/1372 (12%) Query: 73 PFRPKPRFPAPQPL----DNAGLFSYLTVSWLTPLMIQS----LRSRLDENTIP----PL 120 P+ +P P Q D S + +WL PL+ + LR D +P P Sbjct: 155 PWAQEPLLPEDQEPEVAEDGESWLSRFSYAWLAPLLARGACGELRQPQDICRLPHRLQPT 214 Query: 121 SVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLG 180 + + Q RLW G + + L +L+ T L F G Sbjct: 215 YLARVFQAHWQEGARLWRALYGAFG--RCYLALGLLKLVGTMLGFS-------------G 259 Query: 181 PILI--IPKILEYSEEQLGN-VVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAA 237 P+L+ + LE +E L + +++ +GL L +++ + + ++ R A Sbjct: 260 PLLLSLLVGFLEEGQEPLSHGLLYALGLAGGAVLGAVLQNQYGYEVY----KVTLQARGA 315 Query: 238 VSSFAFEKLIQFKSVIHITSGEAISFFTGDVNYL--FEGVCYG----PLVLITCASLVIC 291 V + + K +Q +GEA++ D L F G + PL L L+ Sbjct: 316 VLNILYCKALQL-GPSRPPTGEALNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQ 374 Query: 292 SISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKL 351 + F+ G IL LLV V TR+ Q D R+++ +E+L+ I++ Sbjct: 375 QVGVAFVGGL-----ILALLLVPVNKVIATRIMASNQEMLQH-KDARVKLVTELLSGIRV 428 Query: 352 IKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFI---IPTVATAVWVLIHTSL 408 IK WE+ +E R +E L + +++ L + +++ +P V + V + + + Sbjct: 429 IKFCGWEQALGARVEACRARE---LGRLRVIKYLDAACVYLWAALPVVISIVIFITYVLM 485 Query: 409 KLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQ 468 +LTA+ F+ LA + +L L + P + GL +K ++ R + F + P Q Sbjct: 486 GHQLTATKVFTALALVRMLILPLNNFPWVINGLLEAKVSLDRIQLFL--DLPNHNPQAYY 543 Query: 469 DPSKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELH 528 P + A + W + LE +G + G SL E Sbjct: 544 SPDCGRL--GAQIKWLLCSDPPAEPSTVLELHG----------ALFSWDPVGTSL--ETF 589 Query: 529 KINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG---SLAYVPQQAWIVS 585 +L V KGM++G+ G G GKSSLL+AI E+H L G V V+G Q+ WI Sbjct: 590 ISHLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKGFGLATQEPWIQF 649 Query: 586 GNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLA 645 IR+NIL G +D Y +VL C+LN DL +LP GD TE+GE+G+ LSGGQ+ RI+LA Sbjct: 650 ATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALA 709 Query: 646 RAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILL 705 RAVY ++++YLLDDPL+AVDA V H+ CI L T +L TH+ +YLE ++L+ Sbjct: 710 RAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTEYLERADAVLLM 769 Query: 706 ENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEE 765 E G++ G SE++ Q + K E + TA+ + P+ + L E+ Sbjct: 770 EAGRLIRAGPPSEIL----PLVQAVPKAWAENGQESDSATAQSVQNPEKTKEGLEE--EQ 823 Query: 766 SLNGNAVPEHQLTQEEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFW 825 S +G +L QEE +EG+++ VY Y +A G + I+ F ++L+ + W Sbjct: 824 STSG------RLLQEESKKEGAVALHVYQAYWKAVGQGLALAIL-FSLLLMQATRNAADW 876 Query: 826 WLSYWLEQGSGTNSSRESNGTMADLGNIADNPQL-------------------------- 859 WLS+W+ Q NSS+E+ + + +PQL Sbjct: 877 WLSHWISQLKAENSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDI 936 Query: 860 SFYQLVY----GLNALLLICVGVCSSGIFTKVTRKASTALHNKLFNKVFRCPMSFFDTIP 915 FY VY G+N+L + V +F T +A+ LH +L ++V P++FF+ P Sbjct: 937 RFYLTVYATIAGVNSLCTLLRAV----LFAAGTLQAAATLHRRLLHRVLMAPVTFFNATP 992 Query: 916 IGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFI 975 GR+LN F+ D+ D LP L + ++ +L ++ P++LL+ + ++ + Sbjct: 993 TGRILNRFSSDVACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYH 1052 Query: 976 YYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNY 1035 ++ + +RL + + SPL+SH+ ++L GLS + G T F + RL + Sbjct: 1053 VQRHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRC 1112 Query: 1036 LLLFLSSTRWMALRLEIMTNLVTLAVALFVAF---------GISSTPYSFKVMAVNIVLQ 1086 ++ +W+ +RL++M V A+A G+ S+ + ++ Sbjct: 1113 QFATSATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSG 1172 Query: 1087 LASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEG--TSCPQGWPQHGEIIFQ 1144 L SSF +TEA +VER+ +Y + P +G GW G + FQ Sbjct: 1173 LVSSF-------TQTEAMLVSVERLEEY----TCDLPQEPQGQPLQLGTGWLTQGGVEFQ 1221 Query: 1145 DYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGV 1204 D + YR P L G+ ++ E +GIVGRTGSGKSSL + LFRL+EP +GR+L+DGV Sbjct: 1222 DVVLAYRPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGV 1281 Query: 1205 DICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALE------------ 1252 D + L LRS+L++IPQ+P L SGT+R NLDP H D+ +W AL+ Sbjct: 1282 DTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITSMG 1341 Query: 1253 ------------------------RTFLTKA-IILIDEATASIDMETDTLIQRTIREAFQ 1287 R LT A I+ IDEATAS+D +TD L+Q+TI + F Sbjct: 1342 GLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFA 1401 Query: 1288 GCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATA 1339 TVL IAHR+ T+LN D +LV+ G+VVE D P LR +P SLF L+ ++ Sbjct: 1402 NKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLLQSS 1453 >gi|190343023 ATP-binding cassette, sub-family C, member 6 isoform 1 [Homo sapiens] Length = 1503 Score = 519 bits (1336), Expect = e-147 Identities = 402/1373 (29%), Positives = 631/1373 (45%), Gaps = 182/1373 (13%) Query: 73 PFRPK-PRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQ 131 PF P+ P+ P P A S T W++ L+ + R L + L ++S++ V Sbjct: 191 PFFPEDPQQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVS 250 Query: 132 RLHRLWEEEVS------------RRGIE--KASVLLVMLRFQRT--RLIFDALLGICFCI 175 RL + W S R+G KA LR + + R + A+ + F Sbjct: 251 RLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQV-FHS 309 Query: 176 ASVLGPILII---------PKILEYSEEQLGN----VVHGVGLCFALFLSECVKSLSFSS 222 +LG + +I PK+L E +G+ G L +FLS C+++L Sbjct: 310 TFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQ 369 Query: 223 SWIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPL 280 + + +R R+A++ + K++ S S G+ ++ + DV L E V Y Sbjct: 370 NMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNG 429 Query: 281 VLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEV---SDQ 337 + + +V+C + + ++G +A AI +L + PL F+++ K HH E D Sbjct: 430 LWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISK---KRNHHQEEQMRQKDS 486 Query: 338 RIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVA 397 R R+TS +L K IK + WE F + +R +E L GL+ S++ ++ + + Sbjct: 487 RARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLV 546 Query: 398 TAVWVLIHTSL-KLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFF- 455 V +HT + + + A AF L LN+L + F+P ++ L ++ + R F Sbjct: 547 ALVVFAVHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLC 606 Query: 456 LQESPVFYVQTLQDPSKA----LVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPR 511 L+E V + S A + AT +W Q P Sbjct: 607 LEEVDPGVVDSSSSGSAAGKDCITIHSATFAWSQESP----------------------- 643 Query: 512 DALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQ 571 P LH+INL V +G +L V G G+GKSSLLSA+L E+ +EG V ++ Sbjct: 644 -------------PCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIE 690 Query: 572 GSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERG 631 G++AYVPQ+AW+ + ++ EN+ G D +VL C+L D++ P G T IGE+G Sbjct: 691 GAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQG 750 Query: 632 LNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKK--TLRGKTVVLV 689 +NLSGGQKQR+SLARAVY +YLLDDPL+A+DAHVG+H+F + I L+G T +LV Sbjct: 751 MNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILV 810 Query: 690 THQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEA-TSDMLQDTAKI 748 TH L L II+L NG I E G++ EL+Q+KG L+ + + + + Sbjct: 811 THALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQARQPGDRGEGETEPGTS 870 Query: 749 AEKPKVESQALATSLEESLNGNAVPEHQLTQEEEMEE--------------------GSL 788 + P+ S L + +VPE T E E G + Sbjct: 871 TKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRV 930 Query: 789 SWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMA 848 V+ Y++A G + +F F+ V + +WLS W Sbjct: 931 KATVHLAYLRAVGTPLCLYALFLFLCQQV-ASFCRGYWLSLW------------------ 971 Query: 849 DLGNIADNPQLSFYQLVYGLNALLLICVGVCSS-GIFTKVT------RKASTALHNKLFN 901 AD+P + Q L + +G + G+F + +AS L +L Sbjct: 972 -----ADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLW 1026 Query: 902 KVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPY 961 V R P+SFF+ PIG LLN F+ + + +D +P L+ + ++ V L+V+V +P Sbjct: 1027 DVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATP- 1085 Query: 962 ILLMGAIIMVICFIYYMMFKKAIGV----FKRLENYSRSPLFSHILNSLQGLSSIHVYGK 1017 + + ++ F+ Y F+ V +RLE+ S S + SH+ + QG + + + Sbjct: 1086 ---LATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRT 1142 Query: 1018 TEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFK 1077 F++Q D L + RW+A +E++ N + A A + Sbjct: 1143 QAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLV 1202 Query: 1078 VMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQ 1137 +V+ LQ+ + Q R + E +VER+ Y EAP + + WPQ Sbjct: 1203 GFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDY-AWTPKEAPWRLPTCAAQPPWPQ 1261 Query: 1138 HGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197 G+I F+D+ ++YR P + G++ I E VGIVGRTG+GKSSL L RL E G Sbjct: 1262 GGQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEG 1321 Query: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALE----- 1252 I IDGV I +GL LRS++S+IPQDP+L G++R NLD H+D+ IW ALE Sbjct: 1322 GIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLK 1381 Query: 1253 --------------------------------RTFLTKA-IILIDEATASIDMETDTLIQ 1279 R L K I+++DEATA++D T+ +Q Sbjct: 1382 ALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQ 1441 Query: 1280 RTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLF 1332 + F CTVL+IAHR+ +V++C +LVM G+V E P L + G + Sbjct: 1442 AMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFY 1494 Score = 92.4 bits (228), Expect = 3e-18 Identities = 57/216 (26%), Positives = 109/216 (50%), Gaps = 14/216 (6%) Query: 530 INLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------SLAY 576 ++ + G +G+ G TG+GKSSL S +L EG + + G ++ Sbjct: 1285 VSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISI 1344 Query: 577 VPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSG 636 +PQ + G++R N+ + + L L + LP + +RG +LS Sbjct: 1345 IPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSV 1404 Query: 637 GQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYL 696 GQKQ + LARA+ QI +LD+ +AVD + + + TV+L+ H+L+ + Sbjct: 1405 GQKQLLCLARALLRKTQILILDEATAAVDPGTELQM-QAMLGSWFAQCTVLLIAHRLRSV 1463 Query: 697 EFCGQIILLENGKICENGTHSELMQKKGKYAQLIQK 732 C ++++++ G++ E+G+ ++L+ +KG + +L Q+ Sbjct: 1464 MDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQE 1499 Score = 63.2 bits (152), Expect = 2e-09 Identities = 98/479 (20%), Positives = 193/479 (40%), Gaps = 46/479 (9%) Query: 893 TALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVL 952 +A+ ++ KV +G ++N + D+++L + + + +L L +V+ + Sbjct: 383 SAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFV 442 Query: 953 LIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRL--ENYSRSPLFSHILNSLQGLS 1010 + +L P L A+ + + + + + KK + + SR+ L S IL + + Sbjct: 443 YLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSK--- 499 Query: 1011 SIHVYGKTEDFISQFKRLTDAQNNYL----LLFLSSTRWMALRLEIMTNLVTLAVALFVA 1066 +I +G F+ + + + L LLF S + ++ T LV L V Sbjct: 500 TIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSL----VSFQVSTFLVALVVFAVHT 555 Query: 1067 FGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQF-TAVERILQYMKMCVSEAPLH 1125 + + K VL + + QA + + Q + +R++ ++ C+ E Sbjct: 556 LVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFL--CLEEVDPG 613 Query: 1126 MEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLG 1185 + +S I + +P LH INLT+ ++ +VG G+GKSSL Sbjct: 614 VVDSSSSGSAAGKDCITIHSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLL 673 Query: 1186 MALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQ-------DP-----VLLSGTIR 1233 AL + + G + I+G + + E SV+ DP VL + ++ Sbjct: 674 SALLGELSKVEGFVSIEGA-VAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQ 732 Query: 1234 FNLDPFDRHTDQQIWD-------------ALERTFLTKAII-LIDEATASIDMETDTLIQ 1279 ++D F I + +L R KA + L+D+ A++D + Sbjct: 733 PDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVF 792 Query: 1280 RTI---REAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAAL 1335 + QG T +++ H + + D I+V+ NG + E + L ++ G+L L Sbjct: 793 NQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLL 851 >gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo sapiens] Length = 1581 Score = 518 bits (1335), Expect = e-146 Identities = 385/1415 (27%), Positives = 655/1415 (46%), Gaps = 172/1415 (12%) Query: 55 RAAVPPWGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDE 114 R PP D +R + PF L S T W+ + + + +D Sbjct: 202 REVKPPEDLQDLGVRFLQPF--------------VNLLSKGTYWWMNAFIKTAHKKPIDL 247 Query: 115 NTIPPLSVHDASDKNVQRLHRLWEEEVSR--RGIEKASVLLVMLR--FQRTRLIFDALLG 170 I L + + N QRL ++ +V + +G + A + L F R RL+ + Sbjct: 248 RAIGKLPIAMRALTNYQRLCEAFDAQVRKDIQGTQGARAIWQALSHAFGR-RLVLSSTFR 306 Query: 171 ICFCIASVLGPILIIPKILEYSEEQ---------LGN--------VVHGVGLCFALFLSE 213 I + GP+ I + +E LG + + L LFL+ Sbjct: 307 ILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFLGVYFVSSQEFLANAYVLAVLLFLAL 366 Query: 214 CVKSLSFSSSWIINQRTAIRFRAAVSSFAFEKLIQFK----SVIHITSGEAISFFTGDVN 269 ++ +S+ + T I R A+ + + K++ S+ +T+G+ + D N Sbjct: 367 LLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTN 426 Query: 270 YLFEGVCYGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQH 329 L P + +++ I Y+I+G +A I +L+ P+ F+ +AQ Sbjct: 427 QLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQR 486 Query: 330 HTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSIT 389 T E S++R++ T+E+L IKL+K+Y WE F +E RRKE L + S++ Sbjct: 487 STLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYTSISIFM 546 Query: 390 LFIIPTVATAVWVLIHTSL--KLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSA 447 IP A + + H S + + S+AF+ L+ ++L +F + V+ + + Sbjct: 547 NTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVS 606 Query: 448 VMRFKKFFL-----QESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALELERNGH 502 V + +F +E + T Q P+ +Q +VN + Sbjct: 607 VQKLSEFLSSAEIREEQCAPHEPTPQGPAS---------KYQAVPLRVVNRKRPARED-- 655 Query: 503 ASEGMTRPRDALGPEEEGNS-------LG----------PELHKINLVVSKGMMLGVCGN 545 G+T P +L P +G++ +G P L I + + +G + + G Sbjct: 656 -CRGLTGPLQSLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQ 714 Query: 546 TGSGKSSLLSAILEEMHLLEGSV--------------------------GVQGSLAYVPQ 579 G GKSSLL A L EM + G+V +G +AY Q Sbjct: 715 VGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQ 774 Query: 580 QAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQK 639 + W+++ + ENI+ ++K RY V+ CSL D+++LP GD T+IGERG+NLSGGQ+ Sbjct: 775 KPWLLNATVEENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQR 834 Query: 640 QRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRG--KTVVLVTHQLQYLE 697 QRIS+ARA+Y + LDDP SA+D H+ H+ + I + LR +TVVLVTH+LQYL Sbjct: 835 QRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLP 894 Query: 698 FCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTA---KIAEKPKV 754 II +++G I GT + + + + + + + ++ ++T K E P+ Sbjct: 895 HADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVTERKATEPPQG 954 Query: 755 ESQALATSLEESLNGNAVPEHQLTQEEE--------MEEGSLSWRVYHHYIQAAGGYMVS 806 S+A++ S + L E + + EE + + WR Y+ +AG ++S Sbjct: 955 LSRAMS-SRDGLLQDEEEEEEEAAESEEDDNLSSMLHQRAEIPWRACAKYLSSAGILLLS 1013 Query: 807 CIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVY 866 ++F ++ + L +W L+ W + + N + + + + Q VY Sbjct: 1014 LLVFSQLLKHMVLVAIDYW-LAKWTDSALTLTPAAR---------NCSLSQECTLDQTVY 1063 Query: 867 GLNALLLICVGVCSSGIFTKVT-----RKASTALHNKLFNKVFRCPMSFFDTIPIGRLLN 921 + +L +G+ + T VT K + LH L N++ PM FF+T P+G +LN Sbjct: 1064 AMVFTVLCSLGIVLC-LVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILN 1122 Query: 922 CFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFK 981 F+ D +DQ +P E +L+ ++ L ++S ++P L+ + ++C+ F+ Sbjct: 1123 RFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVISYVTPVFLVALLPLAIVCYFIQKYFR 1182 Query: 982 KAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLS 1041 A ++L++ ++ PL SH +++GL++I + F + TD+ N L + Sbjct: 1183 VASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTA 1242 Query: 1042 STRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMAVNIV--LQLASSFQATARIGL 1099 + RW+ +R+E + V L A+ S ++ + + L +++ R Sbjct: 1243 ANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLA 1302 Query: 1100 ETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLH 1159 + E Q AV+RI +K + + P+ WP G+I Q+ ++Y + VL Sbjct: 1303 DMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLK 1362 Query: 1160 GINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLS 1219 +N I + +GI GRTGSGKSS +A FR+V+ G I+IDG+DI + L LRS+LS Sbjct: 1363 HVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLS 1422 Query: 1220 VIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALE--------------------------- 1252 +I QDPVL SGTIRFNLDP + +D +W+ALE Sbjct: 1423 IILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFS 1482 Query: 1253 ----------RTFLTK-AIILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTV 1301 R F+ K +I ++DEATASIDM T+ ++Q+ + AF TV+ IAHRV T+ Sbjct: 1483 QGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTI 1542 Query: 1302 LNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALM 1336 L+ D ++V+ G ++EFD+PE L + S+FA+ + Sbjct: 1543 LSADLVIVLKRGAILEFDKPEKLLSRKDSVFASFV 1577 >gi|239756495 PREDICTED: hypothetical protein [Homo sapiens] Length = 1312 Score = 518 bits (1335), Expect = e-146 Identities = 399/1366 (29%), Positives = 628/1366 (45%), Gaps = 181/1366 (13%) Query: 79 RFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWE 138 ++ P P A S T W++ L+ + R L + L ++S++ V RL + W Sbjct: 7 KYTNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWM 66 Query: 139 EEVS------------RRGIE--KASVLLVMLRFQRT--RLIFDALLGICFCIASVLGPI 182 S R+G KA LR + + R + A+ + F +LG + Sbjct: 67 RNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQV-FHSTFLLGTL 125 Query: 183 LII---------PKILEYSEEQLGN----VVHGVGLCFALFLSECVKSLSFSSSWIINQR 229 +I PK+L E +G+ G L +FLS C+++L + + Sbjct: 126 SLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKV 185 Query: 230 TAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPLVLITCAS 287 +R R+A++ + K++ S S G+ ++ + DV L E V Y + + Sbjct: 186 LQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVW 245 Query: 288 LVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEV---SDQRIRVTSE 344 +V+C + + ++G +A AI +L + PL F+++ K HH E D R R+TS Sbjct: 246 IVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISK---KRNHHQEEQMRQKDSRARLTSS 302 Query: 345 VLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLI 404 +L K IK + WE F + +R +E L GL+ S++ ++ + + V + Sbjct: 303 ILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAV 362 Query: 405 HTSL-KLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFF-LQESPVF 462 HT + + + A AF L LN+L + F+P ++ L ++ + R F L+E Sbjct: 363 HTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDPG 422 Query: 463 YVQTLQDPSKA----LVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEE 518 V + S A + + AT +W Q P Sbjct: 423 AVDSSSSGSAAGKDCITIQSATFAWSQESP------------------------------ 452 Query: 519 EGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVP 578 P LH+INL V +G +L V G G+GKSSLLSA+L E+ +EG V ++G++AYVP Sbjct: 453 ------PCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVP 506 Query: 579 QQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQ 638 Q+AW+ + ++ EN+ G D +VL C+L D++ P G T IGE+G+NLSGGQ Sbjct: 507 QEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQ 566 Query: 639 KQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKK--TLRGKTVVLVTHQLQYL 696 KQR+SLARAVY +YLLDDPL+A+DAHVG+H+F + I L+G T +LVTH L L Sbjct: 567 KQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHIL 626 Query: 697 EFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEA-TSDMLQDTAKIAEKPKVE 755 II+L NG I E G++ EL+Q+KG L+ + + + + + P+ Sbjct: 627 PQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQARQPGDRGEGETEPGTSTKDPRGT 686 Query: 756 SQALATSLEESLNGNAVPEHQLTQEEEMEE--------------------GSLSWRVYHH 795 S L + +VPE T E E G + V+ Sbjct: 687 SAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKATVHLA 746 Query: 796 YIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIAD 855 Y++A G + +F F+ V + +WLS W AD Sbjct: 747 YLRAVGTPLCLYALFLFLCQQV-ASFCRGYWLSLW-----------------------AD 782 Query: 856 NPQLSFYQLVYGLNALLLICVGVCSS-GIFTKVT------RKASTALHNKLFNKVFRCPM 908 +P + Q L + +G + G+F + +AS L +L V R P+ Sbjct: 783 DPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPI 842 Query: 909 SFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAI 968 SFF+ PIG LLN F+ + + +D +P L+ + ++ V L+V+V +P + + Sbjct: 843 SFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATP----LATV 898 Query: 969 IMVICFIYYMMFKKAIGV----FKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQ 1024 ++ F+ Y F+ V +RLE+ S S + SH+ + QG + + + F++Q Sbjct: 899 AILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQ 958 Query: 1025 FKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMAVNIV 1084 D L + RW+A +E++ N + A A + +V+ Sbjct: 959 NNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAA 1018 Query: 1085 LQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQ 1144 LQ+ + Q R + E +VER+ Y EAP + + WPQ G+I FQ Sbjct: 1019 LQVTQTLQWVVRNWTDLENSIVSVERMQDY-AWTPKEAPWRLPTCAAQPPWPQGGQIEFQ 1077 Query: 1145 DYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGV 1204 D+ ++YR P + G++ I E VGIVGRTG+GKSSL L RL E G I IDGV Sbjct: 1078 DFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGV 1137 Query: 1205 DICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALE------------ 1252 I +GL LRS++S+IPQDP+L G++R NLD H+D+ IW ALE Sbjct: 1138 PIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLP 1197 Query: 1253 -------------------------RTFLTKA-IILIDEATASIDMETDTLIQRTIREAF 1286 R L K I+++DEATA++D T+ +Q + F Sbjct: 1198 GQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWF 1257 Query: 1287 QGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLF 1332 CTVL+IAHR+ +V++C +LVM G+V E P L + G + Sbjct: 1258 AQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFY 1303 Score = 92.4 bits (228), Expect = 3e-18 Identities = 57/216 (26%), Positives = 109/216 (50%), Gaps = 14/216 (6%) Query: 530 INLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------SLAY 576 ++ + G +G+ G TG+GKSSL S +L EG + + G ++ Sbjct: 1094 VSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISI 1153 Query: 577 VPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSG 636 +PQ + G++R N+ + + L L + LP + +RG +LS Sbjct: 1154 IPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSV 1213 Query: 637 GQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYL 696 GQKQ + LARA+ QI +LD+ +AVD + + + TV+L+ H+L+ + Sbjct: 1214 GQKQLLCLARALLRKTQILILDEATAAVDPGTELQM-QAMLGSWFAQCTVLLIAHRLRSV 1272 Query: 697 EFCGQIILLENGKICENGTHSELMQKKGKYAQLIQK 732 C ++++++ G++ E+G+ ++L+ +KG + +L Q+ Sbjct: 1273 MDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQE 1308 Score = 64.3 bits (155), Expect = 7e-10 Identities = 99/479 (20%), Positives = 193/479 (40%), Gaps = 46/479 (9%) Query: 893 TALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVL 952 +A+ ++ KV +G ++N + D+++L + + + +L L +V+ + Sbjct: 192 SAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFV 251 Query: 953 LIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRL--ENYSRSPLFSHILNSLQGLS 1010 + +L P L A+ + + + + + KK + + SR+ L S IL + + Sbjct: 252 YLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSK--- 308 Query: 1011 SIHVYGKTEDFISQFKRLTDAQNNYL----LLFLSSTRWMALRLEIMTNLVTLAVALFVA 1066 +I +G F+ + + + L LLF S + ++ T LV L V Sbjct: 309 TIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSL----VSFQVSTFLVALVVFAVHT 364 Query: 1067 FGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQF-TAVERILQYMKMCVSEAPLH 1125 + + K VL + + QA + + Q + +R++ ++ C+ E Sbjct: 365 LVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFL--CLEEVDPG 422 Query: 1126 MEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLG 1185 +S I Q + +P LH INLT+ ++ +VG G+GKSSL Sbjct: 423 AVDSSSSGSAAGKDCITIQSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLL 482 Query: 1186 MALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQ-------DP-----VLLSGTIR 1233 AL + + G + I+G + + E SV+ DP VL + ++ Sbjct: 483 SALLGELSKVEGFVSIEGA-VAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQ 541 Query: 1234 FNLDPFDRHTDQQIWD-------------ALERTFLTKAII-LIDEATASIDMETDTLIQ 1279 ++D F I + +L R KA + L+D+ A++D + Sbjct: 542 PDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVF 601 Query: 1280 RTI---REAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAAL 1335 + QG T +++ H + + D I+V+ NG + E + L ++ G+L L Sbjct: 602 NQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLL 660 >gi|110832837 ATP-binding cassette, sub-family C, member 9 isoform SUR2B [Homo sapiens] Length = 1549 Score = 510 bits (1314), Expect = e-144 Identities = 391/1396 (28%), Positives = 644/1396 (46%), Gaps = 172/1396 (12%) Query: 59 PPWGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIP 118 PP D +R + PF L S T W+ L+I + + +D I Sbjct: 204 PPEDLQDLGVRFLQPF--------------VNLLSKATYWWMNTLIISAHKKPIDLKAIG 249 Query: 119 PLSVHDASDKNVQRLHRLWEEE---VSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCI 175 L + + N L +EE+ V+ S+ L M R ++ + + Sbjct: 250 KLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADL 309 Query: 176 ASVLGPILIIPKILEYSEEQLG-NVVHGVG--------------LCFALFLSECVKSLSF 220 GP+ I + +E Q G N G+ L LFL+ ++ Sbjct: 310 LGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQRTFL 369 Query: 221 SSSWIINQRTAIRFRAAVSSFAFEKLIQFK----SVIHITSGEAISFFTGDVNYLFEGVC 276 +S+ + T I R A+ + + K+++ S+ +T G+ + + N L + Sbjct: 370 QASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLF 429 Query: 277 YGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSD 336 P + +++ I Y ++G +A + +L+ P+ F+ +AQ T + S Sbjct: 430 LCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYST 489 Query: 337 QRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTV 396 +R++ T+E+L IKL+K+Y WE F K +E+ R KE L+ L SL+ IP Sbjct: 490 ERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIA 549 Query: 397 ATAVWVLIHTSLK-LKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFF 455 A + H L + AF+ L+ ++L +F + V+ + +V + +F Sbjct: 550 AVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFL 609 Query: 456 LQESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVN----GALELERNGHASEGMTRPR 511 L + + + +L FE P +N G L+ ++ + RP Sbjct: 610 LSDE--IGDDSWRTGESSLPFESCK-KHTGVQPKTINRKQPGRYHLDSYEQSTRRL-RPA 665 Query: 512 DAL--------GPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHL 563 + G G+ L L I++ + G + + G G GKSSLL AIL EM Sbjct: 666 ETEDIAIKVTNGYFSWGSGLAT-LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQT 724 Query: 564 LEGSVGVQG-----------------SLAYVPQQAWIVSGNIRENILMGGAYDKARYLQV 606 LEG V S+AY Q+ W+++ + ENI G ++K RY V Sbjct: 725 LEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAV 784 Query: 607 LHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDA 666 CSL D++LLPFGD TEIGERG+NLSGGQ+QRI +ARA+Y + I LDDP SA+D Sbjct: 785 TDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDI 844 Query: 667 HVGKHIFEECIKKTLRG--KTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKG 724 H+ H+ +E I K L+ +T+VLVTH+LQYL II +++G + GT ++ K Sbjct: 845 HLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDV 904 Query: 725 K----YAQLIQKMHKEATSDMLQDTAKIAEKP---KVESQALATSLEESLNGNAVPEHQL 777 + + L+ + +E DM D + K + S+ +E+ E + Sbjct: 905 ELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMED--------EDEE 956 Query: 778 TQEEEMEEGSLS----------WRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWL 827 +EEE E+ ++S W+ Y+ +GG+ + ++ F +L + + +WL Sbjct: 957 EEEEEDEDDNMSTVMRLRTKMPWKTCWRYL-TSGGFFLLILMIFSKLLKHSVIVAIDYWL 1015 Query: 828 SYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIF--- 884 + W + S N+ + ++Y V G + L C +GIF Sbjct: 1016 ATWTSEYSINNTGKADQ---------------TYY--VAGFSIL-------CGAGIFLCL 1051 Query: 885 -TKVTRK-----ASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFS 938 T +T + A+ LH+ L NK+ P+ FFDT P+G +LN F+ D +DQ +P Sbjct: 1052 VTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTL 1111 Query: 939 EQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPL 998 E +L+ ++ + ++S +P L+ + V + F+ A + L++ ++ PL Sbjct: 1112 ESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPL 1171 Query: 999 FSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVT 1058 H + +GL++I + F + LTD N L ++ RW+ +R + + + Sbjct: 1172 LCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIV 1231 Query: 1059 LAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMC 1118 L ++ G S++ + + L + + R + E Q AV+++ ++ M Sbjct: 1232 LTASIASISGSSNS--GLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTME 1289 Query: 1119 VSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTG 1178 M+ + P+ WPQ GEI D ++Y +N VL + I+ + VGI GRTG Sbjct: 1290 SENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTG 1349 Query: 1179 SGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDP 1238 SGKSSL +A FR+V+ G+I+IDG+DI + L LRS+LS+I QDP+L SG+IRFNLDP Sbjct: 1350 SGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDP 1409 Query: 1239 FDRHTDQQIWDALE-------------------------------------RTFLTKAII 1261 + TD ++W+ALE R F+ K+ I Sbjct: 1410 ECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSI 1469 Query: 1262 LI-DEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDR 1320 LI DEATASIDM T+ ++Q+ + AF TV+ IAHRV T+L D ++VM G ++E+D Sbjct: 1470 LIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDT 1529 Query: 1321 PEVLRKKPGSLFAALM 1336 PE L + +FA+ + Sbjct: 1530 PESLLAQENGVFASFV 1545 Score = 89.7 bits (221), Expect = 2e-17 Identities = 61/225 (27%), Positives = 105/225 (46%), Gaps = 15/225 (6%) Query: 521 NSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------- 572 N+L P L + + G +G+CG TGSGKSSL A + + +G + + G Sbjct: 1323 NNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPL 1382 Query: 573 -----SLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEI 627 L+ + Q + SG+IR N+ R + L L ++ LP G + Sbjct: 1383 HTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVV 1442 Query: 628 GERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVV 687 E G N S GQ+Q LARA I ++D+ +++D ++I ++ + +TVV Sbjct: 1443 TEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDM-ATENILQKVVMTAFADRTVV 1501 Query: 688 LVTHQLQYLEFCGQIILLENGKICENGT-HSELMQKKGKYAQLIQ 731 + H++ + +I+++ G I E T S L Q+ G +A ++ Sbjct: 1502 TIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQENGVFASFVR 1546 >gi|110832839 ATP-binding cassette, sub-family C, member 9 isoform SUR2A-delta-14 [Homo sapiens] Length = 1513 Score = 502 bits (1292), Expect = e-141 Identities = 390/1387 (28%), Positives = 639/1387 (46%), Gaps = 186/1387 (13%) Query: 59 PPWGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIP 118 PP D +R + PF L S T W+ L+I + + +D I Sbjct: 204 PPEDLQDLGVRFLQPF--------------VNLLSKATYWWMNTLIISAHKKPIDLKAIG 249 Query: 119 PLSVHDASDKNVQRLHRLWEEE---VSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCI 175 L + + N L +EE+ V+ S+ L M R ++ + + Sbjct: 250 KLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADL 309 Query: 176 ASVLGPILIIPKILEYSEEQLG-NVVHGVG--------------LCFALFLSECVKSLSF 220 GP+ I + +E Q G N G+ L LFL+ ++ Sbjct: 310 LGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQRTFL 369 Query: 221 SSSWIINQRTAIRFRAAVSSFAFEKLIQFK----SVIHITSGEAISFFTGDVNYLFEGVC 276 +S+ + T I R A+ + + K+++ S+ +T G+ + + N L + Sbjct: 370 QASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLF 429 Query: 277 YGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSD 336 P + +++ I Y ++G +A + +L+ P+ F+ +AQ T + S Sbjct: 430 LCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYST 489 Query: 337 QRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTV 396 +R++ T+E+L IKL+K+Y WE F K +E+ R KE L+ L SL+ IP Sbjct: 490 ERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIA 549 Query: 397 ATAVWVLIHTSLK-LKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFF 455 A + H L + AF+ L+ ++L +F + V+ + +V + +F Sbjct: 550 AVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFL 609 Query: 456 LQESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRDALG 515 L + + + +L FE + G+V NG+ S G Sbjct: 610 LSDE--IGDDSWRTGESSLPFESC-----KKHTGVVT-------NGYFSWG--------- 646 Query: 516 PEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG--- 572 S L I++ + G + + G G GKSSLL AIL EM LEG V Sbjct: 647 ------SGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNE 700 Query: 573 --------------SLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLEL 618 S+AY Q+ W+++ + ENI G ++K RY V CSL D++L Sbjct: 701 SEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDL 760 Query: 619 LPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIK 678 LPFGD TEIGERG+NLSGGQ+QRI +ARA+Y + I LDDP SA+D H+ H+ +E I Sbjct: 761 LPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGIL 820 Query: 679 KTLRG--KTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGK----YAQLIQK 732 K L+ +T+VLVTH+LQYL II +++G + GT ++ K + + L+ + Sbjct: 821 KFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNR 880 Query: 733 MHKEATSDMLQDTAKIAEKP---KVESQALATSLEESLNGNAVPEHQLTQEEEMEEGSLS 789 +E DM D + K + S+ +E+ E + +EEE E+ ++S Sbjct: 881 QDQELEKDMEADQTTLERKTLRRAMYSREAKAQMED--------EDEEEEEEEDEDDNMS 932 Query: 790 ----------WRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNS 839 W+ Y+ +GG+ + ++ F +L + + +WL+ W + S N+ Sbjct: 933 TVMRLRTKMPWKTCWRYL-TSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINNT 991 Query: 840 SRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIF----TKVTRK----- 890 + ++Y V G + L C +GIF T +T + Sbjct: 992 GKADQ---------------TYY--VAGFSIL-------CGAGIFLCLVTSLTVEWMGLT 1027 Query: 891 ASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIA 950 A+ LH+ L NK+ P+ FFDT P+G +LN F+ D +DQ +P E +L+ ++ Sbjct: 1028 AAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLS 1087 Query: 951 VLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLS 1010 + ++S +P L+ + V + F+ A + L++ ++ PL H + +GL+ Sbjct: 1088 AIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLT 1147 Query: 1011 SIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGIS 1070 +I + F + LTD N L ++ RW+ +R + + + L ++ G S Sbjct: 1148 TIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSS 1207 Query: 1071 STPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTS 1130 ++ + + L + + R + E Q AV+++ ++ M M+ + Sbjct: 1208 NS--GLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQ 1265 Query: 1131 CPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFR 1190 P+ WPQ GEI D ++Y +N VL + I+ + VGI GRTGSGKSSL +A FR Sbjct: 1266 VPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFR 1325 Query: 1191 LVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDA 1250 +V+ G+I+IDG+DI + L LRS+LS+I QDP+L SG+IRFNLDP + TD ++W+A Sbjct: 1326 MVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEA 1385 Query: 1251 LE-------------------------------------RTFLTKAIILI-DEATASIDM 1272 LE R F+ K+ ILI DEATASIDM Sbjct: 1386 LEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDM 1445 Query: 1273 ETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDR-PEVLRKKPGSL 1331 T+ ++Q+ + AF TV+ IAHRV+++++ +LV G +VE D P +L K G L Sbjct: 1446 ATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNG-L 1504 Query: 1332 FAALMAT 1338 F+ L+ T Sbjct: 1505 FSTLVMT 1511 >gi|110832835 ATP-binding cassette, sub-family C, member 9 isoform SUR2A [Homo sapiens] Length = 1549 Score = 500 bits (1288), Expect = e-141 Identities = 392/1399 (28%), Positives = 645/1399 (46%), Gaps = 174/1399 (12%) Query: 59 PPWGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIP 118 PP D +R + PF L S T W+ L+I + + +D I Sbjct: 204 PPEDLQDLGVRFLQPF--------------VNLLSKATYWWMNTLIISAHKKPIDLKAIG 249 Query: 119 PLSVHDASDKNVQRLHRLWEEE---VSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCI 175 L + + N L +EE+ V+ S+ L M R ++ + + Sbjct: 250 KLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADL 309 Query: 176 ASVLGPILIIPKILEYSEEQLG-NVVHGVG--------------LCFALFLSECVKSLSF 220 GP+ I + +E Q G N G+ L LFL+ ++ Sbjct: 310 LGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQRTFL 369 Query: 221 SSSWIINQRTAIRFRAAVSSFAFEKLIQFK----SVIHITSGEAISFFTGDVNYLFEGVC 276 +S+ + T I R A+ + + K+++ S+ +T G+ + + N L + Sbjct: 370 QASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLF 429 Query: 277 YGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSD 336 P + +++ I Y ++G +A + +L+ P+ F+ +AQ T + S Sbjct: 430 LCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYST 489 Query: 337 QRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTV 396 +R++ T+E+L IKL+K+Y WE F K +E+ R KE L+ L SL+ IP Sbjct: 490 ERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIA 549 Query: 397 ATAVWVLIHTSLK-LKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFF 455 A + H L + AF+ L+ ++L +F + V+ + +V + +F Sbjct: 550 AVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFL 609 Query: 456 LQESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVN----GALELERNGHASEGMTRPR 511 L + + + +L FE P +N G L+ ++ + RP Sbjct: 610 LSDE--IGDDSWRTGESSLPFESCK-KHTGVQPKTINRKQPGRYHLDSYEQSTRRL-RPA 665 Query: 512 DAL--------GPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHL 563 + G G+ L L I++ + G + + G G GKSSLL AIL EM Sbjct: 666 ETEDIAIKVTNGYFSWGSGLAT-LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQT 724 Query: 564 LEGSVGVQG-----------------SLAYVPQQAWIVSGNIRENILMGGAYDKARYLQV 606 LEG V S+AY Q+ W+++ + ENI G ++K RY V Sbjct: 725 LEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAV 784 Query: 607 LHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDA 666 CSL D++LLPFGD TEIGERG+NLSGGQ+QRI +ARA+Y + I LDDP SA+D Sbjct: 785 TDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDI 844 Query: 667 HVGKHIFEECIKKTLRG--KTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKG 724 H+ H+ +E I K L+ +T+VLVTH+LQYL II +++G + GT ++ K Sbjct: 845 HLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDV 904 Query: 725 K----YAQLIQKMHKEATSDMLQDTAKIAEKP---KVESQALATSLEESLNGNAVPEHQL 777 + + L+ + +E DM D + K + S+ +E+ E + Sbjct: 905 ELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMED--------EDEE 956 Query: 778 TQEEEMEEGSLS----------WRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWL 827 +EEE E+ ++S W+ Y+ +GG+ + ++ F +L + + +WL Sbjct: 957 EEEEEDEDDNMSTVMRLRTKMPWKTCWRYL-TSGGFFLLILMIFSKLLKHSVIVAIDYWL 1015 Query: 828 SYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIF--- 884 + W + S N+ + ++Y V G + L C +GIF Sbjct: 1016 ATWTSEYSINNTGKADQ---------------TYY--VAGFSIL-------CGAGIFLCL 1051 Query: 885 -TKVTRK-----ASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFS 938 T +T + A+ LH+ L NK+ P+ FFDT P+G +LN F+ D +DQ +P Sbjct: 1052 VTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTL 1111 Query: 939 EQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPL 998 E +L+ ++ + ++S +P L+ + V + F+ A + L++ ++ PL Sbjct: 1112 ESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPL 1171 Query: 999 FSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVT 1058 H + +GL++I + F + LTD N L ++ RW+ +R + + + Sbjct: 1172 LCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIV 1231 Query: 1059 LAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMC 1118 L ++ G S++ + + L + + R + E Q AV+++ ++ M Sbjct: 1232 LTASIASISGSSNS--GLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTME 1289 Query: 1119 VSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTG 1178 M+ + P+ WPQ GEI D ++Y +N VL + I+ + VGI GRTG Sbjct: 1290 SENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTG 1349 Query: 1179 SGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDP 1238 SGKSSL +A FR+V+ G+I+IDG+DI + L LRS+LS+I QDP+L SG+IRFNLDP Sbjct: 1350 SGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDP 1409 Query: 1239 FDRHTDQQIWDALE-------------------------------------RTFLTKAII 1261 + TD ++W+ALE R F+ K+ I Sbjct: 1410 ECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSI 1469 Query: 1262 LI-DEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDR 1320 LI DEATASIDM T+ ++Q+ + AF TV+ IAHRV+++++ +LV G +VE D Sbjct: 1470 LIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDT 1529 Query: 1321 -PEVLRKKPGSLFAALMAT 1338 P +L K G LF+ L+ T Sbjct: 1530 VPNLLAHKNG-LFSTLVMT 1547 >gi|134142345 ATP-binding cassette, sub-family C, member 1 isoform 3 [Homo sapiens] Length = 1475 Score = 470 bits (1209), Expect = e-132 Identities = 357/1374 (25%), Positives = 617/1374 (44%), Gaps = 232/1374 (16%) Query: 81 PAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEE 140 P P P +A S +T W+T L+++ R L+ + + L+ D S++ V L + W++E Sbjct: 205 PNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKE 264 Query: 141 VSRRGIEKASVL-----------------------LVMLRFQR--TRLIFDAL---LGIC 172 ++ + V+ L++ Q+ +F L G Sbjct: 265 CAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPY 324 Query: 173 FCIASVLGPI---------LIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSS 223 F ++ I I+ ++++ + G LF++ C+++L Sbjct: 325 FLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQY 384 Query: 224 WIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPLV 281 + I + +R + AV + K + + +S GE ++ + D + Y ++ Sbjct: 385 FHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMI 444 Query: 282 LITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRV 341 +++ + +G + + +L+ P+ M Q + D RI++ Sbjct: 445 WSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKL 504 Query: 342 TSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVW 401 +E+L IK++K+Y WE F + +R++E K+L+K + ++ + T P + Sbjct: 505 MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCT 564 Query: 402 VLIHTSLKLK--LTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQES 459 ++ ++ L A AF LA N+LR + +P+ + + + ++ R + F E Sbjct: 565 FAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEE 624 Query: 460 ---PVFYVQTLQDP--SKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRDAL 514 + ++D + ++ AT +W ++ P +NG Sbjct: 625 LEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNG--------------------- 663 Query: 515 GPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSL 574 I + +G ++ V G G GKSSLLSA+L EM +EG V ++GS+ Sbjct: 664 ---------------ITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSV 708 Query: 575 AYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNL 634 AYVPQQAWI + ++RENIL G ++ Y V+ C+L DLE+ L Sbjct: 709 AYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEI---------------L 753 Query: 635 SGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQ 694 G + I KT +LVTH + Sbjct: 754 PSGDRTEIG---------------------------------------EKTRILVTHSMS 774 Query: 695 YLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAKIA----- 749 YL II++ GKI E G++ EL+ + G +A+ ++ A+++ QD + Sbjct: 775 YLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTY---ASTEQEQDAEENGVTGVS 831 Query: 750 ----EKPKVESQALAT-----------SLEESLNGNAVPEHQLTQE-------------- 780 E ++E+ L T S S +G+ H T E Sbjct: 832 GPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKL 891 Query: 781 ---EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGT 837 ++ + G + VY Y++A G ++ IF F+ V + S +WLS W + Sbjct: 892 MEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVS-ALASNYWLSLWTDDPIVN 950 Query: 838 NSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHN 897 + + ++ G + + ++ V+G + + V GI AS LH Sbjct: 951 GTQEHTKVRLSVYGALGISQGIA----VFGYS------MAVSIGGIL------ASRCLHV 994 Query: 898 KLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSV 957 L + + R PMSFF+ P G L+N F+ +L+ +D ++P + F+ VI +++ + Sbjct: 995 DLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILL 1054 Query: 958 LSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGK 1017 +P ++ + +I F + + KRLE+ SRSP++SH +L G+S I + + Sbjct: 1055 ATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEE 1114 Query: 1018 TEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFK 1077 E FI Q D + + RW+A+RLE + N + L ALF S Sbjct: 1115 QERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLV 1174 Query: 1078 VMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQ 1137 ++V+ LQ+ + R+ E E AVER+ +Y + EAP ++ T+ P WPQ Sbjct: 1175 GLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET-EKEAPWQIQETAPPSSWPQ 1233 Query: 1138 HGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197 G + F++Y ++YR++ VL IN+TI G E VGIVGRTG+GKSSL + LFR+ E G Sbjct: 1234 VGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEG 1293 Query: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALE----- 1252 I+IDG++I IGL DLR K+++IPQDPVL SG++R NLDPF +++D+++W +LE Sbjct: 1294 EIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLK 1353 Query: 1253 --------------------------------RTFLTKA-IILIDEATASIDMETDTLIQ 1279 R L K I+++DEATA++D+ETD LIQ Sbjct: 1354 DFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQ 1413 Query: 1280 RTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFA 1333 TIR F+ CTVL IAHR+ T+++ ++V+ G++ E+ P L ++ G ++ Sbjct: 1414 STIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYS 1467 Score = 90.9 bits (224), Expect = 7e-18 Identities = 65/224 (29%), Positives = 105/224 (46%), Gaps = 18/224 (8%) Query: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573 L IN+ ++ G +G+ G TG+GKSSL + EG + + G Sbjct: 1254 LRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFK 1313 Query: 574 LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLN 633 + +PQ + SG++R N+ Y L L + LP E E G N Sbjct: 1314 ITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGEN 1373 Query: 634 LSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQL 693 LS GQ+Q + LARA+ +I +LD+ +AVD + + I+ TV+ + H+L Sbjct: 1374 LSVGQRQLVCLARALLRKTKILVLDEATAAVDLET-DDLIQSTIRTQFEDCTVLTIAHRL 1432 Query: 694 QYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEA 737 + ++I+L+ G+I E G S+L+Q++G L M K+A Sbjct: 1433 NTIMDYTRVIVLDKGEIQEYGAPSDLLQQRG----LFYSMAKDA 1472 Score = 48.1 bits (113), Expect = 6e-05 Identities = 92/474 (19%), Positives = 188/474 (39%), Gaps = 72/474 (15%) Query: 890 KASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVI 949 + TA+ ++ K S + +G ++N + D ++ L + + +++ Sbjct: 394 RIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVIL 453 Query: 950 AVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKA----IGVFKRLENYSRSPLFSHILNS 1005 A+ L+ L P +L A+++++ + +M K + K +N R L + ILN Sbjct: 454 ALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDN--RIKLMNEILNG 511 Query: 1006 LQGLS--SIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWM-----------ALRLEI 1052 ++ L + + K + + + L + + L + + W+ A+ + I Sbjct: 512 IKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTI 571 Query: 1053 MTNLVTLAVALFVA---FGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVE 1109 N + A FV+ F I P + M ++ ++Q + S + E + ++E Sbjct: 572 DENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIE 631 Query: 1110 RILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHE 1169 R P+ G + I ++ + + P L+GI +I Sbjct: 632 R-----------RPVKDGGGT--------NSITVRNATFTWARSDPPTLNGITFSIPEGA 672 Query: 1170 VVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLS 1229 +V +VG+ G GKSSL AL ++ + G + I G ++ +PQ + + Sbjct: 673 LVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG-------------SVAYVPQQAWIQN 719 Query: 1230 GTIRFNLDPFDRHTDQQIWDALERTFLTKAIILID-EATASIDMETDTLIQRTIREAFQG 1288 ++R N+ Q+ + R+ + +L D E S D R Sbjct: 720 DSLRENI-----LFGCQLEEPYYRSVIQACALLPDLEILPSGD-----------RTEIGE 763 Query: 1289 CTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATATSS 1342 T +++ H ++ + D I+VM GK+ E + L + G+ FA + T S+ Sbjct: 764 KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGA-FAEFLRTYAST 816 >gi|134142340 ATP-binding cassette, sub-family C, member 1 isoform 2 [Homo sapiens] Length = 1472 Score = 423 bits (1087), Expect = e-118 Identities = 266/781 (34%), Positives = 410/781 (52%), Gaps = 98/781 (12%) Query: 630 RGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECI--KKTLRGKTVV 687 +G+NLSGGQKQR+SLARAVYS+ IYL DDPLSAVDAHVGKHIFE I K L+ KT + Sbjct: 705 KGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRI 764 Query: 688 LVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAK 747 LVTH + YL II++ GKI E G++ EL+ + G +A+ ++ A+++ QD + Sbjct: 765 LVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTY---ASTEQEQDAEE 821 Query: 748 IA---------EKPKVESQALAT-----------SLEESLNGNAVPEHQLTQE------- 780 E ++E+ L T S S +G+ H T E Sbjct: 822 NGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAK 881 Query: 781 ----------EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYW 830 ++ + G + VY Y++A G ++ IF F+ V + S +WLS W Sbjct: 882 KEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVS-ALASNYWLSLW 940 Query: 831 LEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRK 890 + + + ++ G + + ++ V+G + + V GI Sbjct: 941 TDDPIVNGTQEHTKVRLSVYGALGISQGIA----VFGYS------MAVSIGGIL------ 984 Query: 891 ASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIA 950 AS LH L + + R PMSFF+ P G L+N F+ +L+ +D ++P + F+ VI Sbjct: 985 ASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIG 1044 Query: 951 VLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLS 1010 +++ + +P ++ + +I F + + KRLE+ SRSP++SH +L G+S Sbjct: 1045 ACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVS 1104 Query: 1011 SIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGIS 1070 I + + E FI Q D + + RW+A+RLE + N + L ALF Sbjct: 1105 VIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRH 1164 Query: 1071 STPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTS 1130 S ++V+ LQ+ + R+ E E AVER+ +Y + EAP ++ T+ Sbjct: 1165 SLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET-EKEAPWQIQETA 1223 Query: 1131 CPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFR 1190 P WPQ G + F++Y ++YR++ VL IN+TI G E VGIVGRTG+GKSSL + LFR Sbjct: 1224 PPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFR 1283 Query: 1191 LVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDA 1250 + E G I+IDG++I IGL DLR K+++IPQDPVL SG++R NLDPF +++D+++W + Sbjct: 1284 INESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTS 1343 Query: 1251 LE-------------------------------------RTFLTKA-IILIDEATASIDM 1272 LE R L K I+++DEATA++D+ Sbjct: 1344 LELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDL 1403 Query: 1273 ETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLF 1332 ETD LIQ TIR F+ CTVL IAHR+ T+++ ++V+ G++ E+ P L ++ G + Sbjct: 1404 ETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFY 1463 Query: 1333 A 1333 + Sbjct: 1464 S 1464 Score = 106 bits (265), Expect = 1e-22 Identities = 110/540 (20%), Positives = 220/540 (40%), Gaps = 86/540 (15%) Query: 81 PAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEE 140 P P P +A S +T W+T L+++ R L+ + + L+ D S++ V L + W++E Sbjct: 205 PNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKE 264 Query: 141 VSRRGIEKASVL-----------------------LVMLRFQR--TRLIFDAL---LGIC 172 ++ + V+ L++ Q+ +F L G Sbjct: 265 CAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPY 324 Query: 173 FCIASVLGPI---------LIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSS 223 F ++ I I+ ++++ + G LF++ C+++L Sbjct: 325 FLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQY 384 Query: 224 WIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPLV 281 + I + +R + AV + K + + +S GE ++ + D + Y ++ Sbjct: 385 FHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMI 444 Query: 282 LITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRV 341 +++ + +G + + +L+ P+ M Q + D RI++ Sbjct: 445 WSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKL 504 Query: 342 TSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITL----FIIPTVA 397 +E+L IK++K+Y WE F + +R++E K+L+K + ++ + T F++ Sbjct: 505 MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCT 564 Query: 398 TAVWVLIHTSLKLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQ 457 AV+V I + L A AF LA N+LR + +P+ + + + ++ R + F Sbjct: 565 FAVYVTIDEN--NILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSH 622 Query: 458 ES---PVFYVQTLQD--PSKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRD 512 E + ++D + ++ AT +W ++ P +NG Sbjct: 623 EELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNG------------------- 663 Query: 513 ALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG 572 I + +G ++ V G G GKSSLLSA+L EM +EG V ++G Sbjct: 664 -----------------ITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG 706 Score = 90.9 bits (224), Expect = 7e-18 Identities = 65/224 (29%), Positives = 105/224 (46%), Gaps = 18/224 (8%) Query: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573 L IN+ ++ G +G+ G TG+GKSSL + EG + + G Sbjct: 1251 LRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFK 1310 Query: 574 LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLN 633 + +PQ + SG++R N+ Y L L + LP E E G N Sbjct: 1311 ITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGEN 1370 Query: 634 LSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQL 693 LS GQ+Q + LARA+ +I +LD+ +AVD + + I+ TV+ + H+L Sbjct: 1371 LSVGQRQLVCLARALLRKTKILVLDEATAAVDLET-DDLIQSTIRTQFEDCTVLTIAHRL 1429 Query: 694 QYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEA 737 + ++I+L+ G+I E G S+L+Q++G L M K+A Sbjct: 1430 NTIMDYTRVIVLDKGEIQEYGAPSDLLQQRG----LFYSMAKDA 1469 Score = 50.8 bits (120), Expect = 9e-06 Identities = 92/476 (19%), Positives = 186/476 (39%), Gaps = 79/476 (16%) Query: 890 KASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVI 949 + TA+ ++ K S + +G ++N + D ++ L + + +++ Sbjct: 394 RIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVIL 453 Query: 950 AVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKA----IGVFKRLENYSRSPLFSHILNS 1005 A+ L+ L P +L A+++++ + +M K + K +N R L + ILN Sbjct: 454 ALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDN--RIKLMNEILNG 511 Query: 1006 LQGLS--SIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWM-----------ALRLEI 1052 ++ L + + K + + + L + + L + + W+ A+ + I Sbjct: 512 IKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTI 571 Query: 1053 MTNLVTLAVALFVA---FGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVE 1109 N + A FV+ F I P + M ++ ++Q + S + E + ++E Sbjct: 572 DENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIE 631 Query: 1110 RILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHE 1169 R P+ G + I ++ + + P L+GI +I Sbjct: 632 R-----------RPVKDGGGT--------NSITVRNATFTWARSDPPTLNGITFSIPEGA 672 Query: 1170 VVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLS 1229 +V +VG+ G GKSSL AL ++ + G + I GV+ LS + V L+ Sbjct: 673 LVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGVN------------LSGGQKQRVSLA 720 Query: 1230 GTIRFNLDPFDRHTDQQIWDALERTFLTKAIILIDEATASIDMETDTLIQRTI---REAF 1286 + N D I L D+ +++D I + + Sbjct: 721 RAVYSNAD----------------------IYLFDDPLSAVDAHVGKHIFENVIGPKGML 758 Query: 1287 QGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATATSS 1342 + T +++ H ++ + D I+VM GK+ E + L + G+ FA + T S+ Sbjct: 759 KNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGA-FAEFLRTYAST 813 >gi|157502203 ATP-binding cassette, sub-family C, member 4 isoform 2 [Homo sapiens] Length = 859 Score = 391 bits (1004), Expect = e-108 Identities = 272/888 (30%), Positives = 436/888 (49%), Gaps = 81/888 (9%) Query: 83 PQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEEVS 142 P PL +A L S + WL PL + RL+E+ + + D S + L W++EV Sbjct: 10 PNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVL 69 Query: 143 R--RGIEKASVLLVMLR-FQRTRLIFDALLGICFCI---ASVLGPILIIPKILEYSE--E 194 R +K S+ +++ + ++ L+ LGI I A V+ PI + KI+ Y E + Sbjct: 70 RAENDAQKPSLTRAIIKCYWKSYLV----LGIFTLIEESAKVIQPIFL-GKIINYFENYD 124 Query: 195 QLGNVVHGVGLCFALFLSECVKSLSFSSSWIIN--QRTAIRFRAAVSSFAFEKLIQFKSV 252 + +V +A L+ C L+ Q +R R A+ + K ++ ++ Sbjct: 125 PMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNM 184 Query: 253 I--HITSGEAISFFTGDVNYLFEGVCY------GPLVLITCASLVICSISSYFIIGYTAF 304 T+G+ ++ + DVN + + GPL I +L+ + IG + Sbjct: 185 AMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALL------WMEIGISCL 238 Query: 305 IAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKI 364 + +++ PL ++ + T+ +D RIR +EV+T I++IKMY WEK F+ + Sbjct: 239 AGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNL 298 Query: 365 IEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLASL 424 I +LR+KE + + ++ + + F + V + L +TAS F + Sbjct: 299 ITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLY 358 Query: 425 NLLRLSV-FFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVF-EEATLS 482 +RL+V F P A++ ++ + ++ R + F L + + L K +V ++ T Sbjct: 359 GAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAF 418 Query: 483 WQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLGV 542 W + ASE P L ++ V G +L V Sbjct: 419 WDK-----------------ASET------------------PTLQGLSFTVRPGELLAV 443 Query: 543 CGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKAR 602 G G+GKSSLLSA+L E+ G V V G +AYV QQ W+ SG +R NIL G Y+K R Sbjct: 444 VGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKER 503 Query: 603 YLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLS 662 Y +V+ C+L +DL+LL GD+T IG+RG LSGGQK R++LARAVY D IYLLDDPLS Sbjct: 504 YEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLS 563 Query: 663 AVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQK 722 AVDA V +H+FE CI + L K +LVTHQLQYL+ QI++L++GK+ + GT++E ++ Sbjct: 564 AVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKS 623 Query: 723 KGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALA-TSLEESLNGNAVPEHQLTQ-- 779 + L++K ++E+ + T + + ES + S SL A+ E Q T+ Sbjct: 624 GIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGAL-ESQDTENV 682 Query: 780 -----EEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQG 834 EE EG + ++ Y +Y +A ++V + + WWLSYW Sbjct: 683 PVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYW---- 738 Query: 835 SGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTA 894 N N T+ GN+ + L++Y +Y + + G+ S + V +S Sbjct: 739 --ANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQT 796 Query: 895 LHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFL 942 LHNK+F + + P+ FFD PIGR+LN F+ D+ LD LLP+ F+ Sbjct: 797 LHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFI 844 Score = 57.4 bits (137), Expect = 9e-08 Identities = 75/391 (19%), Positives = 150/391 (38%), Gaps = 46/391 (11%) Query: 894 ALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLL 953 A+ + ++ K R G+++N + D+ + DQ+ +F L IAV Sbjct: 169 AMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVT-VFLHFLWAGPLQAIAVTA 227 Query: 954 IVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIH 1013 ++ + L G +++I F K + + + G+ I Sbjct: 228 LLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIK 287 Query: 1014 VYGKTEDF-----------ISQFKRLTDAQNNYLLLFLSSTR---WMALRLEIMTNLVTL 1059 +Y + F IS+ R + + L F S+++ ++ ++ V Sbjct: 288 MYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVIT 347 Query: 1060 AVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCV 1119 A +FVA T Y + V + A + A + + F ++ I Q + Sbjct: 348 ASRVFVAV----TLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLP 403 Query: 1120 SEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGS 1179 S+ + W + E TPT L G++ T+R E++ +VG G+ Sbjct: 404 SDGKKMVHVQDFTAFWDKASE-------------TPT-LQGLSFTVRPGELLAVVGPVGA 449 Query: 1180 GKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPF 1239 GKSSL A+ + P S GL + +++ + Q P + SGT+R N+ Sbjct: 450 GKSSLLSAVLGELAP-------------SHGLVSVHGRIAYVSQQPWVFSGTLRSNILFG 496 Query: 1240 DRHTDQQIWDALERTFLTKAIILIDEATASI 1270 ++ ++ ++ L K + L+++ ++ Sbjct: 497 KKYEKERYEKVIKACALKKDLQLLEDGDLTV 527 >gi|134142342 ATP-binding cassette, sub-family C, member 1 isoform 4 [Homo sapiens] Length = 1416 Score = 347 bits (889), Expect = 6e-95 Identities = 225/725 (31%), Positives = 364/725 (50%), Gaps = 96/725 (13%) Query: 684 KTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQ 743 KT +LVTH + YL II++ GKI E G++ EL+ + G +A+ ++ A+++ Q Sbjct: 705 KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTY---ASTEQEQ 761 Query: 744 DTAKIA---------EKPKVESQALAT-----------SLEESLNGNAVPEHQLTQE--- 780 D + E ++E+ L T S S +G+ H T E Sbjct: 762 DAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQK 821 Query: 781 --------------EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWW 826 ++ + G + VY Y++A G ++ IF F+ V + S +W Sbjct: 822 AEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVS-ALASNYW 880 Query: 827 LSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTK 886 LS W + + + ++ G + + ++ V+G + + V GI Sbjct: 881 LSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIA----VFGYS------MAVSIGGIL-- 928 Query: 887 VTRKASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSL 946 AS LH L + + R PMSFF+ P G L+N F+ +L+ +D ++P + F+ Sbjct: 929 ----ASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLF 984 Query: 947 MVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSL 1006 VI +++ + +P ++ + +I F + + KRLE+ SRSP++SH +L Sbjct: 985 NVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETL 1044 Query: 1007 QGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVA 1066 G+S I + + E FI Q D + + RW+A+RLE + N + L ALF Sbjct: 1045 LGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAV 1104 Query: 1067 FGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHM 1126 S ++V+ LQ+ + R+ E E AVER+ +Y + EAP + Sbjct: 1105 ISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET-EKEAPWQI 1163 Query: 1127 EGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGM 1186 + T+ P WPQ G + F++Y ++YR++ VL IN+TI G E VGIVGRTG+GKSSL + Sbjct: 1164 QETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTL 1223 Query: 1187 ALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQ 1246 LFR+ E G I+IDG++I IGL DLR K+++IPQDPVL SG++R NLDPF +++D++ Sbjct: 1224 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEE 1283 Query: 1247 IWDALE-------------------------------------RTFLTKA-IILIDEATA 1268 +W +LE R L K I+++DEATA Sbjct: 1284 VWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATA 1343 Query: 1269 SIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKP 1328 ++D+ETD LIQ TIR F+ CTVL IAHR+ T+++ ++V+ G++ E+ P L ++ Sbjct: 1344 AVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQR 1403 Query: 1329 GSLFA 1333 G ++ Sbjct: 1404 GLFYS 1408 Score = 108 bits (270), Expect = 3e-23 Identities = 122/600 (20%), Positives = 243/600 (40%), Gaps = 103/600 (17%) Query: 81 PAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEE 140 P P P +A S +T W+T L+++ R L+ + + L+ D S++ V L + W++E Sbjct: 205 PNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKE 264 Query: 141 VSRRGIEKASVL-----------------------LVMLRFQR--TRLIFDAL---LGIC 172 ++ + V+ L++ Q+ +F L G Sbjct: 265 CAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPY 324 Query: 173 FCIASVLGPI---------LIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSS 223 F ++ I I+ ++++ + G LF++ C+++L Sbjct: 325 FLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQY 384 Query: 224 WIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPLV 281 + I + +R + AV + K + + +S GE ++ + D + Y ++ Sbjct: 385 FHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMI 444 Query: 282 LITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRV 341 +++ + +G + + +L+ P+ M Q + D RI++ Sbjct: 445 WSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKL 504 Query: 342 TSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITL----FIIPTVA 397 +E+L IK++K+Y WE F + +R++E K+L+K + ++ + T F++ Sbjct: 505 MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCT 564 Query: 398 TAVWVLIHTSLKLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQ 457 AV+V I + L A AF LA N+LR + +P+ + + + ++ R + F Sbjct: 565 FAVYVTIDEN--NILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSH 622 Query: 458 ES---PVFYVQTLQD--PSKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRD 512 E + ++D + ++ AT +W ++ P +NG Sbjct: 623 EELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNG------------------- 663 Query: 513 ALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQ- 571 I + +G ++ V G G GKSSLLSA+L EM +EG V ++ Sbjct: 664 -----------------ITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKT 706 Query: 572 -----GSLAYVPQQAWIV---------SGNIRENILMGGAYDKARYLQVLHCCSLNRDLE 617 S++Y+PQ I+ G+ +E + GA+ A +L+ +D E Sbjct: 707 RILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAF--AEFLRTYASTEQEQDAE 764 Score = 90.9 bits (224), Expect = 7e-18 Identities = 65/224 (29%), Positives = 105/224 (46%), Gaps = 18/224 (8%) Query: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573 L IN+ ++ G +G+ G TG+GKSSL + EG + + G Sbjct: 1195 LRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFK 1254 Query: 574 LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLN 633 + +PQ + SG++R N+ Y L L + LP E E G N Sbjct: 1255 ITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGEN 1314 Query: 634 LSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQL 693 LS GQ+Q + LARA+ +I +LD+ +AVD + + I+ TV+ + H+L Sbjct: 1315 LSVGQRQLVCLARALLRKTKILVLDEATAAVDLET-DDLIQSTIRTQFEDCTVLTIAHRL 1373 Query: 694 QYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEA 737 + ++I+L+ G+I E G S+L+Q++G L M K+A Sbjct: 1374 NTIMDYTRVIVLDKGEIQEYGAPSDLLQQRG----LFYSMAKDA 1413 Score = 39.3 bits (90), Expect = 0.026 Identities = 64/332 (19%), Positives = 134/332 (40%), Gaps = 41/332 (12%) Query: 890 KASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVI 949 + TA+ ++ K S + +G ++N + D ++ L + + +++ Sbjct: 394 RIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVIL 453 Query: 950 AVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKA----IGVFKRLENYSRSPLFSHILNS 1005 A+ L+ L P +L A+++++ + +M K + K +N R L + ILN Sbjct: 454 ALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDN--RIKLMNEILNG 511 Query: 1006 LQGLS--SIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWM-----------ALRLEI 1052 ++ L + + K + + + L + + L + + W+ A+ + I Sbjct: 512 IKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTI 571 Query: 1053 MTNLVTLAVALFVA---FGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVE 1109 N + A FV+ F I P + M ++ ++Q + S + E + ++E Sbjct: 572 DENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIE 631 Query: 1110 RILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHE 1169 R P+ G + I ++ + + P L+GI +I Sbjct: 632 R-----------RPVKDGGGT--------NSITVRNATFTWARSDPPTLNGITFSIPEGA 672 Query: 1170 VVGIVGRTGSGKSSLGMALFRLVEPMAGRILI 1201 +V +VG+ G GKSSL AL ++ + G + I Sbjct: 673 LVAVVGQVGCGKSSLLSALLAEMDKVEGHVAI 704 >gi|90421313 cystic fibrosis transmembrane conductance regulator [Homo sapiens] Length = 1480 Score = 250 bits (639), Expect = 6e-66 Identities = 180/642 (28%), Positives = 314/642 (48%), Gaps = 20/642 (3%) Query: 85 PLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEEVSRR 144 PL+ A + S L SW P++ + R RL+ + I + D++D ++L R W+ E++ + Sbjct: 5 PLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASK 64 Query: 145 GIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLGPILIIPKILEYS----EEQLGNVV 200 + ++ + R R +F + + + P+L+ I Y EE+ + Sbjct: 65 --KNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIY 122 Query: 201 HGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSSFAFEKLIQFKSVI--HITSG 258 G+GLC LF+ V++L + ++ R A+ S ++K ++ S + I+ G Sbjct: 123 LGIGLCL-LFI---VRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIG 178 Query: 259 EAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAV 318 + +S + ++N EG+ V I + + + ++ +AF + +++ Sbjct: 179 QLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQA 238 Query: 319 FMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEK 378 + RM +K + + +R+ +TSE++ I+ +K Y WE+ K+IE+LR+ E KL K Sbjct: 239 GLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRK 298 Query: 379 CGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLASLNLLRLSVFF-VPIA 437 V+ S F + VL + +K + F+ ++ +LR++V P A Sbjct: 299 AAYVRYFNSSAFFFSGFFVVFLSVLPYALIK-GIILRKIFTTISFCIVLRMAVTRQFPWA 357 Query: 438 VKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALEL 497 V+ +S A+ + + F ++ L + +V E T W++ + A + Sbjct: 358 VQTWYDSLGAINKIQDFLQKQEYKTLEYNLT--TTEVVMENVTAFWEEGFGELFEKAKQN 415 Query: 498 ERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAI 557 N S G D+L P L IN + +G +L V G+TG+GK+SLL I Sbjct: 416 NNNRKTSNG----DDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVI 471 Query: 558 LEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLE 617 + E+ EG + G +++ Q +WI+ G I+ENI+ G +YD+ RY V+ C L D+ Sbjct: 472 MGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDIS 531 Query: 618 LLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECI 677 D +GE G+ LSGGQ+ RISLARAVY D +YLLD P +D K IFE C+ Sbjct: 532 KFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCV 591 Query: 678 KKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSEL 719 K + KT +LVT ++++L+ +I++L G GT SEL Sbjct: 592 CKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSEL 633 Score = 233 bits (595), Expect = 7e-61 Identities = 174/658 (26%), Positives = 302/658 (45%), Gaps = 82/658 (12%) Query: 731 QKMHKEATSDMLQDTAKIAEKPKVE-----------SQALATSLEESLNGNAVPEHQLTQ 779 Q +H++ T+ T K++ P+ SQ + E +N + E Sbjct: 781 QNIHRKTTAS----TRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDD 836 Query: 780 EEEMEEGSLSWRVYHHYIQAAGGY---MVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSG 836 E + + +W Y YI ++ C++ F + L + W L Q G Sbjct: 837 MESIPAVT-TWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVL--WLLGNTPLQDKG 893 Query: 837 TNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALH 896 NS+ N + A + I + + G+ A L+ +G S LH Sbjct: 894 -NSTHSRNNSYAVI--ITSTSSYYVFYIYVGV-ADTLLAMGFFRGLPLVHTLITVSKILH 949 Query: 897 NKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVS 956 +K+ + V + PMS +T+ G +LN F+ D+ LD LLP+ F+ L L+VI + +V+ Sbjct: 950 HKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVA 1009 Query: 957 VLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYG 1016 VL PYI + ++V + F + K+LE+ RSP+F+H++ SL+GL ++ +G Sbjct: 1010 VLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFG 1069 Query: 1017 KTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSF 1076 + F + F + + L+LS+ RW +R+E++ + +AV F++ + Sbjct: 1070 RQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVT-FISILTTGEGEGR 1128 Query: 1077 KVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAP------------- 1123 + + + + + S+ Q ++ ++ +V R+ +++ M P Sbjct: 1129 VGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLS 1188 Query: 1124 --LHMEGTSCPQG--WPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGS 1179 + +E + + WP G++ +D KY + +L I+ +I + VG++GRTGS Sbjct: 1189 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGS 1248 Query: 1180 GKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPF 1239 GKS+L A RL+ G I IDGV SI L+ R VIPQ + SGT R NLDP+ Sbjct: 1249 GKSTLLSAFLRLLN-TEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPY 1307 Query: 1240 DRHTDQQIWD-------------------------------------ALERTFLTKA-II 1261 ++ +DQ+IW L R+ L+KA I+ Sbjct: 1308 EQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKIL 1367 Query: 1262 LIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFD 1319 L+DE +A +D T +I+RT+++AF CTV++ HR+ +L C LV+ KV ++D Sbjct: 1368 LLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYD 1425 Score = 90.5 bits (223), Expect = 1e-17 Identities = 72/263 (27%), Positives = 126/263 (47%), Gaps = 21/263 (7%) Query: 518 EEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG----- 572 E GN++ L I+ +S G +G+ G TGSGKS+LLSA L ++ EG + + G Sbjct: 1221 EGGNAI---LENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEGEIQIDGVSWDS 1276 Query: 573 --------SLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDM 624 + +PQ+ +I SG R+N+ + +V L +E P Sbjct: 1277 ITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLD 1336 Query: 625 TEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGK 684 + + G LS G KQ + LAR+V S +I LLD+P + +D V I +K+ Sbjct: 1337 FVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDP-VTYQIIRRTLKQAFADC 1395 Query: 685 TVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQD 744 TV+L H+++ + C Q +++E K+ + + +L+ ++ + Q I + ++ Sbjct: 1396 TVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPH-RN 1454 Query: 745 TAKIAEKPKVESQALATSLEESL 767 ++K KP++ AL EE + Sbjct: 1455 SSKCKSKPQI--AALKEETEEEV 1475 Score = 37.4 bits (85), Expect = 0.098 Identities = 20/53 (37%), Positives = 30/53 (56%), Gaps = 1/53 (1%) Query: 1157 VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDG-VDICS 1208 VL IN I +++ + G TG+GK+SL M + +EP G+I G + CS Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCS 492 >gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sapiens] Length = 1280 Score = 179 bits (455), Expect = 1e-44 Identities = 274/1210 (22%), Positives = 487/1210 (40%), Gaps = 231/1210 (19%) Query: 258 GEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIGYT-AFIAILCYLLVFPL 316 GE + T DV+ + EG+ G + + S+ + + FI+G+T + L L + P+ Sbjct: 169 GELNTRLTDDVSKINEGI--GDKIGMFFQSMA--TFFTGFIVGFTRGWKLTLVILAISPV 224 Query: 317 AVFMTRMAVKAQHHTSEVSDQRI-------RVTSEVLTCIKLIKMYTWEKPFAKIIEDLR 369 + K S +D+ + V EVL I+ + + +K ++L Sbjct: 225 LGLSAAVWAKI---LSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQK------KELE 275 Query: 370 RKERKLLE--KCGLVQSLTS------ITLFIIPTVATAVWVLIHTSLKLKLTASMAFSML 421 R + L E + G+ +++T+ L I + A A W L + + ++ Sbjct: 276 RYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVF 335 Query: 422 ASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEATL 481 S+ + SV +++ N++ A K + + + Sbjct: 336 FSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSI-----------------DSY 378 Query: 482 SWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLG 541 S P + G LE RN H S P + + L +NL V G + Sbjct: 379 SKSGHKPDNIKGNLEF-RNVHFSY----------PSRKEVKI---LKGLNLKVQSGQTVA 424 Query: 542 VCGNTGSGKSSLLSAILEEMHLLEGSVGVQGS-------------LAYVPQQAWIVSGNI 588 + GN+G GKS+ + + EG V V G + V Q+ + + I Sbjct: 425 LVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTI 484 Query: 589 RENILMGGAYDKARYLQ-VLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARA 647 ENI G ++ + + + LP T +GERG LSGGQKQRI++ARA Sbjct: 485 AENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARA 544 Query: 648 VYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLEN 707 + + +I LLD+ SA+D + + + + K +G+T +++ H+L + I ++ Sbjct: 545 LVRNPKILLLDEATSALDTE-SEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDD 603 Query: 708 GKICENGTHSELMQKKGKYAQLI------QKMHKEATSDMLQ---DTAKIAEKPKVESQA 758 G I E G H ELM++KG Y +L+ ++ E +D + D +++ S Sbjct: 604 GVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRSSLI 663 Query: 759 LATSLEESLNGNAVPEHQLTQEEEMEEG---SLSWRVYHHYIQAAGGYMVS--CIIFFFV 813 S S+ G+ + +L+ +E ++E WR+ + ++V C I Sbjct: 664 RKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGG 723 Query: 814 VLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLL 873 + F IFS + + D+P+ + L +LL Sbjct: 724 LQPAFAIIFS----------------------KIIGVFTRIDDPETK--RQNSNLFSLLF 759 Query: 874 ICVGVCS-------SGIFTKVTRKASTALHNKLFNKVFRCPMSFFD--TIPIGRLLNCFA 924 + +G+ S F K + L +F + R +S+FD G L A Sbjct: 760 LALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLA 819 Query: 925 GDLEQ----LDQLLPIFSEQFLVLSLMVI-------AVLLIVSVLSPYILLMGAIIMVIC 973 D Q + L + ++ L +I + L++ + P I + G + M + Sbjct: 820 NDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKML 879 Query: 974 FIYYMMFKK-----------AIGVFKRLENYSRSPLFSHI-LNSLQ-----GLSSIHVYG 1016 + KK AI F+ + + ++ F H+ SLQ L H++G Sbjct: 880 SGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFG 939 Query: 1017 KTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSF 1076 T F +Y F +A +L M+ L V V FG Sbjct: 940 ITFSFTQAMMYF-----SYAGCFRFGAYLVAHKL--MSFEDVLLVFSAVVFG-------- 984 Query: 1077 KVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPL----HMEG--TS 1130 MAV V A + +A+ +A I M + + PL EG + Sbjct: 985 -AMAVGQVSSFAPDY---------AKAKISAAHII-----MIIEKTPLIDSYSTEGLMPN 1029 Query: 1131 CPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFR 1190 +G GE++F + R + P VL G++L ++ + + +VG +G GKS++ L R Sbjct: 1030 TLEGNVTFGEVVF---NYPTRPDIP-VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLER 1085 Query: 1191 LVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFD--RHTDQQ-- 1246 +P+AG++L+DG +I + ++ LR+ L ++ Q+P+L +I N+ D R Q+ Sbjct: 1086 FYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEI 1145 Query: 1247 -----------IWDALERTFLTKA--------------------------IILIDEATAS 1269 ++L + TK I+L+DEAT++ Sbjct: 1146 VRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSA 1205 Query: 1270 IDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPG 1329 +D E++ ++Q + +A +G T +VIAHR++T+ N D I+V NG+V E + L + G Sbjct: 1206 LDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKG 1265 Query: 1330 SLFAALMATA 1339 F+ + A Sbjct: 1266 IYFSMVSVQA 1275 >gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11 [Homo sapiens] Length = 1321 Score = 167 bits (424), Expect = 5e-41 Identities = 214/919 (23%), Positives = 381/919 (41%), Gaps = 158/919 (17%) Query: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573 L+ +N+V+ G M + G +G+GKS+ L I EG V V G Sbjct: 438 LNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQ 497 Query: 574 LAYVPQQAWIVSGNIRENILMGGAYDKAR-YLQVLHCCSLNRDLELLPFGDMTEIGERGL 632 + V Q+ + S I ENI G +Q + + LP T +GE G Sbjct: 498 IGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGG 557 Query: 633 NLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQ 692 +SGGQKQR+++ARA+ + +I LLD SA+D + + + +E + K G T++ V H+ Sbjct: 558 QMSGGQKQRVAIARALIRNPKILLLDMATSALD-NESEAMVQEVLSKIQHGHTIISVAHR 616 Query: 693 LQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI-----------QKMHKEATSDM 741 L + II E+G E GTH EL+++KG Y L+ ++ K+AT D Sbjct: 617 LSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQSQGNQALNEEDIKDATEDD 676 Query: 742 L----------QDTAKIAEKPKVESQALATSLEESLNGNAVPEHQLTQEEEMEEGSLSWR 791 + QD+ + + + + +SQ E L AV +H+ T EE+ ++ + Sbjct: 677 MLARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPL---AVVDHKSTYEEDRKDKDIP-- 731 Query: 792 VYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLG 851 ++ A V I+ F ++ + S NGT+ L Sbjct: 732 -VQEEVEPA---PVRRILKFSAPEWPYMLVGSV---------------GAAVNGTVTPLY 772 Query: 852 NIADNPQLSFYQLV------YGLNALLLICVGVCSSGIFTKVTRKASTALHNKLFNKVFR 905 + L + + +N + L+ V + +FT+ + + A +L K R Sbjct: 773 AFLFSQILGTFSIPDKEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLR 832 Query: 906 ---------CPMSFFDTI--PIGRLLNCFAGDLEQL-----DQLLPIFSEQFLVLSLMVI 949 +++FD + G L A D Q+ Q+ I + V M+I Sbjct: 833 KFGFRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMII 892 Query: 950 A------VLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHIL 1003 A + L++ P++ L GA + + K+A+ + ++ N Sbjct: 893 AFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITN----------- 941 Query: 1004 NSLQGLSSIHVYGKTEDFI--------SQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTN 1055 +L + ++ GK FI FK N Y F + + + Sbjct: 942 EALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANIYGFCFAFA--------QCIMF 993 Query: 1056 LVTLAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYM 1115 + A + + IS+ F + ++ + S A R T + A ++ Sbjct: 994 IANSASYRYGGYLISNEGLHFSYV-FRVISAVVLSATALGRAFSYTPSYAKAKISAARFF 1052 Query: 1116 KMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPT-VLHGINLTIRGHEVVGIV 1174 ++ + P+ + T+ + G+I F D Y + VL+G++++I + + V Sbjct: 1053 QLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFV 1112 Query: 1175 GRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRF 1234 G +G GKS+ L R +P G+++IDG D + ++ LRS + ++ Q+PVL + +I Sbjct: 1113 GSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMD 1172 Query: 1235 NLD--------PFDR----HTDQQIWDAL-----------------------ERTFLTKA 1259 N+ P +R Q+ D + +R + +A Sbjct: 1173 NIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARA 1232 Query: 1260 II------LIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNG 1313 I+ L+DEAT+++D E++ +Q + +A +G T +VIAHR++T+ N D I VM G Sbjct: 1233 IVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQG 1292 Query: 1314 KVVEFDRPEVLRKKPGSLF 1332 V+E E L + G+ + Sbjct: 1293 VVIEKGTHEELMAQKGAYY 1311 Score = 93.2 bits (230), Expect = 2e-18 Identities = 62/220 (28%), Positives = 110/220 (50%), Gaps = 17/220 (7%) Query: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573 L+ +++ +S G L G++G GKS+ + + +G V + G + Sbjct: 1096 LNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSN 1155 Query: 574 LAYVPQQAWIVSGNIRENILMGGAYDKA---RYLQVLHCCSLNRDLELLPFGDMTEIGER 630 + V Q+ + + +I +NI G + R + L+ + LP T +G + Sbjct: 1156 IGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQ 1215 Query: 631 GLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVT 690 G LS G+KQRI++ARA+ D +I LLD+ SA+D K + + + K G+T +++ Sbjct: 1216 GSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTV-QVALDKAREGRTCIVIA 1274 Query: 691 HQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730 H+L ++ I ++ G + E GTH ELM +KG Y +L+ Sbjct: 1275 HRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLV 1314 Score = 87.8 bits (216), Expect = 6e-17 Identities = 63/234 (26%), Positives = 114/234 (48%), Gaps = 40/234 (17%) Query: 1139 GEIIFQDYHMKYRDNTPT-VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197 GEI F + Y +L+ +N+ I+ E+ +VG +G+GKS+ + R +P G Sbjct: 418 GEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEG 477 Query: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNL-------------------DP 1238 + +DG DI S+ ++ LR ++ ++ Q+PVL S TI N+ + Sbjct: 478 MVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANA 537 Query: 1239 FDRHTD-QQIWDAL-------------ERTFLTKA------IILIDEATASIDMETDTLI 1278 ++ D Q +D L +R + +A I+L+D AT+++D E++ ++ Sbjct: 538 YNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMV 597 Query: 1279 QRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLF 1332 Q + + G T++ +AHR++TV D I+ +G VE E L ++ G F Sbjct: 598 QEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYF 651 >gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C [Homo sapiens] Length = 1232 Score = 114 bits (285), Expect = 6e-25 Identities = 68/222 (30%), Positives = 117/222 (52%), Gaps = 17/222 (7%) Query: 525 PELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGS----------- 573 P L ++L V KG L + G++G GKS+++ + L G+V + G Sbjct: 1003 PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLR 1062 Query: 574 --LAYVPQQAWIVSGNIRENILMGG---AYDKARYLQVLHCCSLNRDLELLPFGDMTEIG 628 L V Q+ + +I ENI G + + +++ +E LP T +G Sbjct: 1063 AQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVG 1122 Query: 629 ERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVL 688 ++G LSGGQKQRI++ARA+ QI LLD+ SA+D K + +E + K G+T ++ Sbjct: 1123 DKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEK-VVQEALDKAREGRTCIV 1181 Query: 689 VTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730 + H+L ++ I++ +NG++ E+GTH +L+ +KG Y ++ Sbjct: 1182 IAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMV 1223 Score = 102 bits (253), Expect = 3e-21 Identities = 69/218 (31%), Positives = 109/218 (50%), Gaps = 15/218 (6%) Query: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGS------------- 573 L +NL V G + + G++G GKS+ + I EG++ + G Sbjct: 412 LKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREI 471 Query: 574 LAYVPQQAWIVSGNIRENILMG-GAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGL 632 + V Q+ + S I ENI G G + + + + LP T +GERG Sbjct: 472 IGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGA 531 Query: 633 NLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQ 692 LSGGQKQRI++ARA+ + +I LLD+ SA+D + + + K G+T +++ H+ Sbjct: 532 QLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV-QAALDKAREGRTTIVIAHR 590 Query: 693 LQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730 L + I E+G I E G+HSELM+K+G Y +L+ Sbjct: 591 LSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLV 628 Score = 100 bits (250), Expect = 7e-21 Identities = 70/244 (28%), Positives = 124/244 (50%), Gaps = 44/244 (18%) Query: 1139 GEIIFQDYHMKY--RDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMA 1196 G I F + Y R N P VL G++L ++ + + +VG +G GKS++ L R +P+A Sbjct: 985 GNITFNEVVFNYPTRANVP-VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLA 1043 Query: 1197 GRILIDGVDICSIGLEDLRSKLSVIPQDPVL-----------------------LSGTIR 1233 G +L+DG + + ++ LR++L ++ Q+P+L +S Sbjct: 1044 GTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKA 1103 Query: 1234 FNLDPF-------------DRHTD----QQIWDALERTFLTK-AIILIDEATASIDMETD 1275 N+ PF D+ T Q+ A+ R + + I+L+DEAT+++D E++ Sbjct: 1104 ANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESE 1163 Query: 1276 TLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAAL 1335 ++Q + +A +G T +VIAHR++T+ N D I+V NG+V E + L + G F+ + Sbjct: 1164 KVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMV 1223 Query: 1336 MATA 1339 A Sbjct: 1224 SVQA 1227 Score = 100 bits (249), Expect = 9e-21 Identities = 76/247 (30%), Positives = 119/247 (48%), Gaps = 41/247 (16%) Query: 1139 GEIIFQDYHMKYRDNTPT-VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197 G + F D H Y +L G+NL ++ + V +VG +G GKS+ + RL +P G Sbjct: 392 GNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEG 451 Query: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFN---------LDPFDRHTDQ--- 1245 I IDG DI + + LR + V+ Q+PVL S TI N +D + + Sbjct: 452 TINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANA 511 Query: 1246 --------QIWDAL-------------ERTFLTKA------IILIDEATASIDMETDTLI 1278 Q +D L +R + +A I+L+DEAT+++D E++ + Sbjct: 512 YEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV 571 Query: 1279 QRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAAL-MA 1337 Q + +A +G T +VIAHR++TV N D I +G +VE L KK G F + M Sbjct: 572 QAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQ 631 Query: 1338 TATSSLR 1344 T+ S ++ Sbjct: 632 TSGSQIQ 638 >gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A [Homo sapiens] Length = 1279 Score = 114 bits (285), Expect = 6e-25 Identities = 68/222 (30%), Positives = 117/222 (52%), Gaps = 17/222 (7%) Query: 525 PELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGS----------- 573 P L ++L V KG L + G++G GKS+++ + L G+V + G Sbjct: 1050 PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLR 1109 Query: 574 --LAYVPQQAWIVSGNIRENILMGG---AYDKARYLQVLHCCSLNRDLELLPFGDMTEIG 628 L V Q+ + +I ENI G + + +++ +E LP T +G Sbjct: 1110 AQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVG 1169 Query: 629 ERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVL 688 ++G LSGGQKQRI++ARA+ QI LLD+ SA+D K + +E + K G+T ++ Sbjct: 1170 DKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEK-VVQEALDKAREGRTCIV 1228 Query: 689 VTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730 + H+L ++ I++ +NG++ E+GTH +L+ +KG Y ++ Sbjct: 1229 IAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMV 1270 Score = 102 bits (253), Expect = 3e-21 Identities = 69/218 (31%), Positives = 109/218 (50%), Gaps = 15/218 (6%) Query: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGS------------- 573 L +NL V G + + G++G GKS+ + I EG++ + G Sbjct: 412 LKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREI 471 Query: 574 LAYVPQQAWIVSGNIRENILMG-GAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGL 632 + V Q+ + S I ENI G G + + + + LP T +GERG Sbjct: 472 IGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGA 531 Query: 633 NLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQ 692 LSGGQKQRI++ARA+ + +I LLD+ SA+D + + + K G+T +++ H+ Sbjct: 532 QLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV-QAALDKAREGRTTIVIAHR 590 Query: 693 LQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730 L + I E+G I E G+HSELM+K+G Y +L+ Sbjct: 591 LSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLV 628 Score = 100 bits (250), Expect = 7e-21 Identities = 70/244 (28%), Positives = 124/244 (50%), Gaps = 44/244 (18%) Query: 1139 GEIIFQDYHMKY--RDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMA 1196 G I F + Y R N P VL G++L ++ + + +VG +G GKS++ L R +P+A Sbjct: 1032 GNITFNEVVFNYPTRANVP-VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLA 1090 Query: 1197 GRILIDGVDICSIGLEDLRSKLSVIPQDPVL-----------------------LSGTIR 1233 G +L+DG + + ++ LR++L ++ Q+P+L +S Sbjct: 1091 GTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKA 1150 Query: 1234 FNLDPF-------------DRHTD----QQIWDALERTFLTK-AIILIDEATASIDMETD 1275 N+ PF D+ T Q+ A+ R + + I+L+DEAT+++D E++ Sbjct: 1151 ANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESE 1210 Query: 1276 TLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAAL 1335 ++Q + +A +G T +VIAHR++T+ N D I+V NG+V E + L + G F+ + Sbjct: 1211 KVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMV 1270 Query: 1336 MATA 1339 A Sbjct: 1271 SVQA 1274 Score = 100 bits (249), Expect = 9e-21 Identities = 76/247 (30%), Positives = 119/247 (48%), Gaps = 41/247 (16%) Query: 1139 GEIIFQDYHMKYRDNTPT-VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197 G + F D H Y +L G+NL ++ + V +VG +G GKS+ + RL +P G Sbjct: 392 GNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEG 451 Query: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFN---------LDPFDRHTDQ--- 1245 I IDG DI + + LR + V+ Q+PVL S TI N +D + + Sbjct: 452 TINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANA 511 Query: 1246 --------QIWDAL-------------ERTFLTKA------IILIDEATASIDMETDTLI 1278 Q +D L +R + +A I+L+DEAT+++D E++ + Sbjct: 512 YEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV 571 Query: 1279 QRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAAL-MA 1337 Q + +A +G T +VIAHR++TV N D I +G +VE L KK G F + M Sbjct: 572 QAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQ 631 Query: 1338 TATSSLR 1344 T+ S ++ Sbjct: 632 TSGSQIQ 638 >gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B [Homo sapiens] Length = 1286 Score = 111 bits (277), Expect = 5e-24 Identities = 68/229 (29%), Positives = 117/229 (51%), Gaps = 24/229 (10%) Query: 525 PELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGV-------------- 570 P L ++L V KG L + G++G GKS+++ + L G+V V Sbjct: 1050 PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKK 1109 Query: 571 ------QGSLAYVPQQAWIVSGNIRENILMGG---AYDKARYLQVLHCCSLNRDLELLPF 621 + L V Q+ + +I ENI G + + +++ +E LP Sbjct: 1110 LNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPH 1169 Query: 622 GDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTL 681 T +G++G LSGGQKQRI++ARA+ QI LLD+ SA+D K + +E + K Sbjct: 1170 KYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEK-VVQEALDKAR 1228 Query: 682 RGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730 G+T +++ H+L ++ I++ +NG++ E+GTH +L+ +KG Y ++ Sbjct: 1229 EGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMV 1277 Score = 102 bits (253), Expect = 3e-21 Identities = 69/218 (31%), Positives = 109/218 (50%), Gaps = 15/218 (6%) Query: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGS------------- 573 L +NL V G + + G++G GKS+ + I EG++ + G Sbjct: 412 LKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREI 471 Query: 574 LAYVPQQAWIVSGNIRENILMG-GAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGL 632 + V Q+ + S I ENI G G + + + + LP T +GERG Sbjct: 472 IGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGA 531 Query: 633 NLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQ 692 LSGGQKQRI++ARA+ + +I LLD+ SA+D + + + K G+T +++ H+ Sbjct: 532 QLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV-QAALDKAREGRTTIVIAHR 590 Query: 693 LQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730 L + I E+G I E G+HSELM+K+G Y +L+ Sbjct: 591 LSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLV 628 Score = 100 bits (249), Expect = 9e-21 Identities = 76/247 (30%), Positives = 119/247 (48%), Gaps = 41/247 (16%) Query: 1139 GEIIFQDYHMKYRDNTPT-VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197 G + F D H Y +L G+NL ++ + V +VG +G GKS+ + RL +P G Sbjct: 392 GNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEG 451 Query: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFN---------LDPFDRHTDQ--- 1245 I IDG DI + + LR + V+ Q+PVL S TI N +D + + Sbjct: 452 TINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANA 511 Query: 1246 --------QIWDAL-------------ERTFLTKA------IILIDEATASIDMETDTLI 1278 Q +D L +R + +A I+L+DEAT+++D E++ + Sbjct: 512 YEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV 571 Query: 1279 QRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAAL-MA 1337 Q + +A +G T +VIAHR++TV N D I +G +VE L KK G F + M Sbjct: 572 QAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQ 631 Query: 1338 TATSSLR 1344 T+ S ++ Sbjct: 632 TSGSQIQ 638 Score = 94.0 bits (232), Expect = 9e-19 Identities = 70/251 (27%), Positives = 124/251 (49%), Gaps = 51/251 (20%) Query: 1139 GEIIFQDYHMKY--RDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMA 1196 G I F + Y R N P VL G++L ++ + + +VG +G GKS++ L R +P+A Sbjct: 1032 GNITFNEVVFNYPTRANVP-VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLA 1090 Query: 1197 GRI-------LIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIR---------------- 1233 G + L+DG + + ++ LR++L ++ Q+P+L +I Sbjct: 1091 GTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDE 1150 Query: 1234 -------FNLDPF-------------DRHTD----QQIWDALERTFLTKA-IILIDEATA 1268 N+ PF D+ T Q+ A+ R + + I+L+DEAT+ Sbjct: 1151 IVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATS 1210 Query: 1269 SIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKP 1328 ++D E++ ++Q + +A +G T +VIAHR++T+ N D I+V NG+V E + L + Sbjct: 1211 ALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQK 1270 Query: 1329 GSLFAALMATA 1339 G F+ + A Sbjct: 1271 GIYFSMVSVQA 1281 >gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo sapiens] Length = 738 Score = 110 bits (274), Expect = 1e-23 Identities = 72/229 (31%), Positives = 122/229 (53%), Gaps = 25/229 (10%) Query: 525 PELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG------------ 572 P +L + G + + G +GSGKS++LS +L G++ + G Sbjct: 508 PIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLR 567 Query: 573 -SLAYVPQQAWIVSGNIRENILMGG-------AYDKARYLQVLHCCSLNRDLELLPFGDM 624 + V Q+ + S +I ENI G A + R +V + + R+ P G Sbjct: 568 SKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNF---PQGFN 624 Query: 625 TEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGK 684 T +GE+G+ LSGGQKQRI++ARA+ + +I LLD+ SA+DA +++ +E + + + G+ Sbjct: 625 TVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAE-NEYLVQEALDRLMDGR 683 Query: 685 TVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQK-KGKYAQLIQK 732 TV+++ H+L ++ + +L+ GKI E G H EL+ K G Y +L+ K Sbjct: 684 TVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNK 732 Score = 109 bits (273), Expect = 2e-23 Identities = 130/557 (23%), Positives = 236/557 (42%), Gaps = 88/557 (15%) Query: 850 LGNIAD----NPQLSFY----QLVYGLNALLLICVGVCSSGIFTKVT--RKASTALHNKL 899 LG I D NP + + +L GL+A+ L + ++ T ++ L L Sbjct: 192 LGKIIDVIYTNPTVDYSDNLTRLCLGLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSL 251 Query: 900 FNKVFRCPMSFFDTIPIGRLLNCFAGDL--------EQLDQLLPIFSEQFLVLSLMVIAV 951 F+ + R ++FFD G L+N + D E L L ++ + +S+M Sbjct: 252 FSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMM---- 307 Query: 952 LLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSS 1011 + L+ ++L + + +I IY +K V + ++ +++ + + + + Sbjct: 308 FFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQ--DSLAQATQLAE--ERIGNVRT 363 Query: 1012 IHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISS 1071 + +GK I ++ D + + NL+ L+V + S Sbjct: 364 VRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGS 423 Query: 1072 TPY------SFKVMA--VNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAP 1123 SF + A V I + SSF + GL + E + + K+ +E Sbjct: 424 AHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLW--ELLEREPKLPFNEGV 481 Query: 1124 LHMEGTSCPQGWPQHGEIIFQDYHMKY--RDNTPTVLHGINLTIRGHEVVGIVGRTGSGK 1181 + E + G + F++ H Y R P + +L+I V +VG +GSGK Sbjct: 482 ILNEKSF-------QGALEFKNVHFAYPARPEVP-IFQDFSLSIPSGSVTALVGPSGSGK 533 Query: 1182 SSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNL----- 1236 S++ L RL +P +G I +DG DI + LRSK+ + Q+P+L S +I N+ Sbjct: 534 STVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGAD 593 Query: 1237 DPFDRHTDQ-----QIWDAL--------------------------ERTFLTKA------ 1259 DP ++ ++ +A+ +R + +A Sbjct: 594 DPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPK 653 Query: 1260 IILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFD 1319 I+L+DEAT+++D E + L+Q + G TVLVIAHR++T+ N + + V+ GK+ E+ Sbjct: 654 ILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYG 713 Query: 1320 RPEVLRKKPGSLFAALM 1336 + E L KP ++ LM Sbjct: 714 KHEELLSKPNGIYRKLM 730 >gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo sapiens] Length = 812 Score = 105 bits (262), Expect = 3e-22 Identities = 68/223 (30%), Positives = 119/223 (53%), Gaps = 23/223 (10%) Query: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573 L ++L + +G + G++G GKS+ + + ++G V G Sbjct: 588 LRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQ 647 Query: 574 LAYVPQQAWIVSGNIRENILMGGAYDKARYL------QVLHCCSLNRDLELLPFGDMTEI 627 +A VPQ+ + + +I ENI G D +R + + + +++ +E LP T++ Sbjct: 648 IAIVPQEPVLFNCSIAENIAYG---DNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQV 704 Query: 628 GERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVV 687 G +G LSGGQKQR+++ARA+ +I LLD+ SA+D K + + + K G+T + Sbjct: 705 GLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEK-VVQHALDKARTGRTCL 763 Query: 688 LVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730 +VTH+L ++ I++L NGKI E GTH EL++ + Y +L+ Sbjct: 764 VVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLV 806 Score = 96.3 bits (238), Expect = 2e-19 Identities = 61/202 (30%), Positives = 106/202 (52%), Gaps = 41/202 (20%) Query: 1157 VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRS 1216 +L G++L+I + V VG +G GKS+ L RL +P+ G++L DGVD + ++ LRS Sbjct: 587 ILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRS 646 Query: 1217 KLSVIPQDPVLLSGTIRFNLD--------PFDRHTD------------------------ 1244 +++++PQ+PVL + +I N+ P D + Sbjct: 647 QIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGL 706 Query: 1245 --------QQIWDALERTFLTK-AIILIDEATASIDMETDTLIQRTIREAFQGCTVLVIA 1295 Q+ A+ R L K I+L+DEAT+++D +++ ++Q + +A G T LV+ Sbjct: 707 KGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVT 766 Query: 1296 HRVTTVLNCDHILVMGNGKVVE 1317 HR++ + N D I+V+ NGK+ E Sbjct: 767 HRLSAIQNADLIVVLHNGKIKE 788 Score = 89.0 bits (219), Expect = 3e-17 Identities = 52/153 (33%), Positives = 87/153 (56%), Gaps = 17/153 (11%) Query: 625 TEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGK 684 T +GE+G +SGGQKQRI++ARA+ + +I +LD+ SA+D+ K + ++K +G+ Sbjct: 71 TLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSE-SKSAVQAALEKASKGR 129 Query: 685 TVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQD 744 T ++V H+L + I+ L++G + E G H+ELM K+G Y L+ M QD Sbjct: 130 TTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLV----------MSQD 179 Query: 745 TAKIAEKPKVESQALATSLEESLNGNAVPEHQL 777 K E ++ES +T + N++P H + Sbjct: 180 IKKADE--QMESMTYSTERKT----NSLPLHSV 206 Score = 57.8 bits (138), Expect = 7e-08 Identities = 40/177 (22%), Positives = 80/177 (45%), Gaps = 39/177 (22%) Query: 1200 LIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNL-----DPFDRHTDQQIWDALERT 1254 ++D DI ++ + R + V+ Q+PVL TI N+ D D ++ +A Sbjct: 1 MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYD 60 Query: 1255 FLTK----------------------------------AIILIDEATASIDMETDTLIQR 1280 F+ + I+++DEAT+++D E+ + +Q Sbjct: 61 FIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQA 120 Query: 1281 TIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMA 1337 + +A +G T +V+AHR++T+ + D I+ + +G + E L K G ++ +M+ Sbjct: 121 ALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMS 177 >gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo sapiens] Length = 753 Score = 105 bits (262), Expect = 3e-22 Identities = 76/248 (30%), Positives = 119/248 (47%), Gaps = 40/248 (16%) Query: 1136 PQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPM 1195 PQ + F + H +Y + VL GI+ + + V IVG +GSGKS++ LFR EP Sbjct: 468 PQTATVAFDNVHFEYIEGQK-VLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQ 526 Query: 1196 AGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNL-------DPFDRHT----- 1243 G I + G +I + LE LR + V+PQD VL TI +NL P + + Sbjct: 527 KGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLA 586 Query: 1244 -------------DQQIWD-------------ALERTFL-TKAIILIDEATASIDMETDT 1276 D Q+ + A+ R L +IL DEAT+S+D T+ Sbjct: 587 GLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEE 646 Query: 1277 LIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALM 1336 I +++ + T + IAHR++TV++ D I+V+ GKV E L P S+++ + Sbjct: 647 TILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMW 706 Query: 1337 ATATSSLR 1344 T +S ++ Sbjct: 707 HTQSSRVQ 714 Score = 99.0 bits (245), Expect = 3e-20 Identities = 67/256 (26%), Positives = 124/256 (48%), Gaps = 18/256 (7%) Query: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573 L I+ V G + + G +GSGKS+++ + +GS+ + G + Sbjct: 489 LSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRA 548 Query: 574 LAYVPQQAWIVSGNIRENILMGG-AYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGL 632 + VPQ A + I N+L G + V L+ + +P G T++GERGL Sbjct: 549 VGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGL 608 Query: 633 NLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQ 692 LSGG+KQR+++ARA+ D + L D+ S++D+ + + +K ++ +T + + H+ Sbjct: 609 KLSGGEKQRVAIARAILKDPPVILYDEATSSLDS-ITEETILGAMKDVVKHRTSIFIAHR 667 Query: 693 LQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAK-IAEK 751 L + +II+L+ GK+ E GTH L+ ++ + H +++ D K A+K Sbjct: 668 LSTVVDADEIIVLDQGKVAERGTHHGLL--ANPHSIYSEMWHTQSSRVQNHDNPKWEAKK 725 Query: 752 PKVESQALATSLEESL 767 + + L+E + Sbjct: 726 ENISKEEERKKLQEEI 741 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.324 0.138 0.409 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 46,663,243 Number of Sequences: 37866 Number of extensions: 2031132 Number of successful extensions: 8227 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 75 Number of HSP's successfully gapped in prelim test: 38 Number of HSP's that attempted gapping in prelim test: 7625 Number of HSP's gapped (non-prelim): 388 length of query: 1344 length of database: 18,247,518 effective HSP length: 114 effective length of query: 1230 effective length of database: 13,930,794 effective search space: 17134876620 effective search space used: 17134876620 T: 11 A: 40 X1: 15 ( 7.0 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.5 bits) S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.