Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 21729876

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21729876 ATP-binding cassette, sub-family C, member 11
isoform b [Homo sapiens]
         (1344 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21729876 ATP-binding cassette, sub-family C, member 11 isofor...  2654   0.0  
gi|21729873 ATP-binding cassette, sub-family C, member 11 isofor...  2635   0.0  
gi|15149474 ATP-binding cassette, sub-family C, member 11 isofor...  2635   0.0  
gi|89111135 ATP-binding cassette protein C12 [Homo sapiens]          1203   0.0  
gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform...   949   0.0  
gi|157502201 ATP-binding cassette, sub-family C, member 4 isofor...   640   0.0  
gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform ...   620   e-177
gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member...   591   e-168
gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor...   588   e-167
gi|134142335 ATP-binding cassette, sub-family C, member 1 isofor...   537   e-152
gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo ...   524   e-148
gi|190343023 ATP-binding cassette, sub-family C, member 6 isofor...   519   e-147
gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo ...   518   e-146
gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]           518   e-146
gi|110832837 ATP-binding cassette, sub-family C, member 9 isofor...   510   e-144
gi|110832839 ATP-binding cassette, sub-family C, member 9 isofor...   502   e-141
gi|110832835 ATP-binding cassette, sub-family C, member 9 isofor...   500   e-141
gi|134142345 ATP-binding cassette, sub-family C, member 1 isofor...   470   e-132
gi|134142340 ATP-binding cassette, sub-family C, member 1 isofor...   423   e-118
gi|157502203 ATP-binding cassette, sub-family C, member 4 isofor...   391   e-108
gi|134142342 ATP-binding cassette, sub-family C, member 1 isofor...   347   6e-95
gi|90421313 cystic fibrosis transmembrane conductance regulator ...   250   6e-66
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa...   179   1e-44
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member...   167   5e-41
gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C...   114   6e-25
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A...   114   6e-25
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B...   111   5e-24
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo...   110   1e-23
gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo ...   105   3e-22
gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo s...   105   3e-22

>gi|21729876 ATP-binding cassette, sub-family C, member 11 isoform b
            [Homo sapiens]
          Length = 1344

 Score = 2654 bits (6878), Expect = 0.0
 Identities = 1344/1344 (100%), Positives = 1344/1344 (100%)

Query: 1    MTRKRTYWVPNSSGGLVNRGIDIGDDMVSGLIYKTYTLQDGPWSQQERNPEAPGRAAVPP 60
            MTRKRTYWVPNSSGGLVNRGIDIGDDMVSGLIYKTYTLQDGPWSQQERNPEAPGRAAVPP
Sbjct: 1    MTRKRTYWVPNSSGGLVNRGIDIGDDMVSGLIYKTYTLQDGPWSQQERNPEAPGRAAVPP 60

Query: 61   WGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPL 120
            WGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPL
Sbjct: 61   WGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPL 120

Query: 121  SVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLG 180
            SVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLG
Sbjct: 121  SVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLG 180

Query: 181  PILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSS 240
            PILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSS
Sbjct: 181  PILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSS 240

Query: 241  FAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIG 300
            FAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIG
Sbjct: 241  FAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIG 300

Query: 301  YTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKP 360
            YTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKP
Sbjct: 301  YTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKP 360

Query: 361  FAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSM 420
            FAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSM
Sbjct: 361  FAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSM 420

Query: 421  LASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEAT 480
            LASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEAT
Sbjct: 421  LASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEAT 480

Query: 481  LSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMML 540
            LSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMML
Sbjct: 481  LSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMML 540

Query: 541  GVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDK 600
            GVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDK
Sbjct: 541  GVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDK 600

Query: 601  ARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDP 660
            ARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDP
Sbjct: 601  ARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDP 660

Query: 661  LSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELM 720
            LSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELM
Sbjct: 661  LSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELM 720

Query: 721  QKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEESLNGNAVPEHQLTQE 780
            QKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEESLNGNAVPEHQLTQE
Sbjct: 721  QKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEESLNGNAVPEHQLTQE 780

Query: 781  EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSS 840
            EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSS
Sbjct: 781  EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSS 840

Query: 841  RESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLF 900
            RESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLF
Sbjct: 841  RESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLF 900

Query: 901  NKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSP 960
            NKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSP
Sbjct: 901  NKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSP 960

Query: 961  YILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTED 1020
            YILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTED
Sbjct: 961  YILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTED 1020

Query: 1021 FISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMA 1080
            FISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMA
Sbjct: 1021 FISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMA 1080

Query: 1081 VNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGE 1140
            VNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGE
Sbjct: 1081 VNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGE 1140

Query: 1141 IIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRIL 1200
            IIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRIL
Sbjct: 1141 IIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRIL 1200

Query: 1201 IDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAI 1260
            IDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAI
Sbjct: 1201 IDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAI 1260

Query: 1261 ILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDR 1320
            ILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDR
Sbjct: 1261 ILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDR 1320

Query: 1321 PEVLRKKPGSLFAALMATATSSLR 1344
            PEVLRKKPGSLFAALMATATSSLR
Sbjct: 1321 PEVLRKKPGSLFAALMATATSSLR 1344


>gi|21729873 ATP-binding cassette, sub-family C, member 11 isoform a
            [Homo sapiens]
          Length = 1382

 Score = 2635 bits (6829), Expect = 0.0
 Identities = 1344/1382 (97%), Positives = 1344/1382 (97%), Gaps = 38/1382 (2%)

Query: 1    MTRKRTYWVPNSSGGLVNRGIDIGDDMVSGLIYKTYTLQDGPWSQQERNPEAPGRAAVPP 60
            MTRKRTYWVPNSSGGLVNRGIDIGDDMVSGLIYKTYTLQDGPWSQQERNPEAPGRAAVPP
Sbjct: 1    MTRKRTYWVPNSSGGLVNRGIDIGDDMVSGLIYKTYTLQDGPWSQQERNPEAPGRAAVPP 60

Query: 61   WGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPL 120
            WGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPL
Sbjct: 61   WGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPL 120

Query: 121  SVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLG 180
            SVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLG
Sbjct: 121  SVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLG 180

Query: 181  PILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSS 240
            PILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSS
Sbjct: 181  PILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSS 240

Query: 241  FAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIG 300
            FAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIG
Sbjct: 241  FAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIG 300

Query: 301  YTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKP 360
            YTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKP
Sbjct: 301  YTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKP 360

Query: 361  FAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSM 420
            FAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSM
Sbjct: 361  FAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSM 420

Query: 421  LASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEAT 480
            LASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEAT
Sbjct: 421  LASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEAT 480

Query: 481  LSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMML 540
            LSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMML
Sbjct: 481  LSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMML 540

Query: 541  GVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDK 600
            GVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDK
Sbjct: 541  GVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDK 600

Query: 601  ARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDP 660
            ARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDP
Sbjct: 601  ARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDP 660

Query: 661  LSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELM 720
            LSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELM
Sbjct: 661  LSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELM 720

Query: 721  QKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEESLNGNAVPEHQLTQE 780
            QKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEESLNGNAVPEHQLTQE
Sbjct: 721  QKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEESLNGNAVPEHQLTQE 780

Query: 781  EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSS 840
            EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSS
Sbjct: 781  EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSS 840

Query: 841  RESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLF 900
            RESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLF
Sbjct: 841  RESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLF 900

Query: 901  NKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSP 960
            NKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSP
Sbjct: 901  NKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSP 960

Query: 961  YILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTED 1020
            YILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTED
Sbjct: 961  YILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTED 1020

Query: 1021 FISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMA 1080
            FISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMA
Sbjct: 1021 FISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMA 1080

Query: 1081 VNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGE 1140
            VNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGE
Sbjct: 1081 VNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGE 1140

Query: 1141 IIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRIL 1200
            IIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRIL
Sbjct: 1141 IIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRIL 1200

Query: 1201 IDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKA- 1259
            IDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKA 
Sbjct: 1201 IDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAI 1260

Query: 1260 -------------------------------------IILIDEATASIDMETDTLIQRTI 1282
                                                 IILIDEATASIDMETDTLIQRTI
Sbjct: 1261 SKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTLIQRTI 1320

Query: 1283 REAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATATSS 1342
            REAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATATSS
Sbjct: 1321 REAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATATSS 1380

Query: 1343 LR 1344
            LR
Sbjct: 1381 LR 1382


>gi|15149474 ATP-binding cassette, sub-family C, member 11 isoform a
            [Homo sapiens]
          Length = 1382

 Score = 2635 bits (6829), Expect = 0.0
 Identities = 1344/1382 (97%), Positives = 1344/1382 (97%), Gaps = 38/1382 (2%)

Query: 1    MTRKRTYWVPNSSGGLVNRGIDIGDDMVSGLIYKTYTLQDGPWSQQERNPEAPGRAAVPP 60
            MTRKRTYWVPNSSGGLVNRGIDIGDDMVSGLIYKTYTLQDGPWSQQERNPEAPGRAAVPP
Sbjct: 1    MTRKRTYWVPNSSGGLVNRGIDIGDDMVSGLIYKTYTLQDGPWSQQERNPEAPGRAAVPP 60

Query: 61   WGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPL 120
            WGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPL
Sbjct: 61   WGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPL 120

Query: 121  SVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLG 180
            SVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLG
Sbjct: 121  SVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLG 180

Query: 181  PILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSS 240
            PILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSS
Sbjct: 181  PILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSS 240

Query: 241  FAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIG 300
            FAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIG
Sbjct: 241  FAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIG 300

Query: 301  YTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKP 360
            YTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKP
Sbjct: 301  YTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKP 360

Query: 361  FAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSM 420
            FAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSM
Sbjct: 361  FAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSM 420

Query: 421  LASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEAT 480
            LASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEAT
Sbjct: 421  LASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEAT 480

Query: 481  LSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMML 540
            LSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMML
Sbjct: 481  LSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMML 540

Query: 541  GVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDK 600
            GVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDK
Sbjct: 541  GVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDK 600

Query: 601  ARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDP 660
            ARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDP
Sbjct: 601  ARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDP 660

Query: 661  LSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELM 720
            LSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELM
Sbjct: 661  LSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELM 720

Query: 721  QKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEESLNGNAVPEHQLTQE 780
            QKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEESLNGNAVPEHQLTQE
Sbjct: 721  QKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEESLNGNAVPEHQLTQE 780

Query: 781  EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSS 840
            EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSS
Sbjct: 781  EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSS 840

Query: 841  RESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLF 900
            RESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLF
Sbjct: 841  RESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLF 900

Query: 901  NKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSP 960
            NKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSP
Sbjct: 901  NKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSP 960

Query: 961  YILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTED 1020
            YILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTED
Sbjct: 961  YILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTED 1020

Query: 1021 FISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMA 1080
            FISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMA
Sbjct: 1021 FISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMA 1080

Query: 1081 VNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGE 1140
            VNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGE
Sbjct: 1081 VNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGE 1140

Query: 1141 IIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRIL 1200
            IIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRIL
Sbjct: 1141 IIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRIL 1200

Query: 1201 IDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKA- 1259
            IDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKA 
Sbjct: 1201 IDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAI 1260

Query: 1260 -------------------------------------IILIDEATASIDMETDTLIQRTI 1282
                                                 IILIDEATASIDMETDTLIQRTI
Sbjct: 1261 SKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTLIQRTI 1320

Query: 1283 REAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATATSS 1342
            REAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATATSS
Sbjct: 1321 REAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATATSS 1380

Query: 1343 LR 1344
            LR
Sbjct: 1381 LR 1382


>gi|89111135 ATP-binding cassette protein C12 [Homo sapiens]
          Length = 1359

 Score = 1203 bits (3112), Expect = 0.0
 Identities = 622/1342 (46%), Positives = 862/1342 (64%), Gaps = 78/1342 (5%)

Query: 63   KYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSV 122
            +YD +L+TMIP RP  R  AP P+D+AGL S+ T SWLTP+M++  R RL  +T+PPLS 
Sbjct: 24   RYDPSLKTMIPVRPCARL-APNPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLST 82

Query: 123  HDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLGPI 182
            +D+SD N +R   LW+EEV+R G EKAS+  V+ +FQRTR++ D +  I   I + +GP+
Sbjct: 83   YDSSDTNAKRFRVLWDEEVARVGPEKASLSHVVWKFQRTRVLMDIVANILCIIMAAIGPV 142

Query: 183  LIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSSFA 242
            ++I +IL+ +E   G V  G+GLC ALF +E  K   ++ +W IN RTAIR + A+S+  
Sbjct: 143  ILIHQILQQTERTSGKVWVGIGLCIALFATEFTKVFFWALAWAINYRTAIRLKVALSTLV 202

Query: 243  FEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIGYT 302
            FE L+ FK++ HI+ GE ++  + D   LFE   + PL       +V C+  ++FI+G T
Sbjct: 203  FENLVSFKTLTHISVGEVLNILSSDSYSLFEAALFCPLPATIPILMVFCAAYAFFILGPT 262

Query: 303  AFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFA 362
            A I I  Y++  P+ +FM ++    +     V+D+R++  +E LTCI+LIKMY WEK F 
Sbjct: 263  ALIGISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAWEKSFT 322

Query: 363  KIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLA 422
              I+D+RR+ERKLLEK G VQS  S    I+ T+A  + +  H  L+ KLTA +AFS++A
Sbjct: 323  NTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTLSCHILLRRKLTAPVAFSVIA 382

Query: 423  SLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEATLS 482
              N+++ S+  +P ++K +  +  ++ R KK  + +SP  Y+   +DP   L+   ATL+
Sbjct: 383  MFNVMKFSIAILPFSIKAMAEANVSLRRMKKILIDKSPPSYITQPEDPDTVLLLANATLT 442

Query: 483  WQ------QTCPGIVNGALEL---ERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLV 533
            W+       T   + N    L   +R+   SE     + A GPEE+ +SL   LH I+ V
Sbjct: 443  WEHEASRKSTPKKLQNQKRHLCKKQRSEAYSERSPPAKGATGPEEQSDSLKSVLHSISFV 502

Query: 534  VSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENIL 593
            V KG +LG+CGN GSGKSSLL+A+L +M L +G V V G+LAYV QQAWI  GN+RENIL
Sbjct: 503  VRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGTLAYVSQQAWIFHGNVRENIL 562

Query: 594  MGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQ 653
             G  YD  RY   +  C L +DL  LP+GD+TEIGERGLNLSGGQ+QRISLARAVYSDRQ
Sbjct: 563  FGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERGLNLSGGQRQRISLARAVYSDRQ 622

Query: 654  IYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICEN 713
            +YLLDDPLSAVDAHVGKH+FEECIKKTLRGKTVVLVTHQLQ+LE C ++ILLE+G+ICE 
Sbjct: 623  LYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTHQLQFLESCDEVILLEDGEICEK 682

Query: 714  GTHSELMQKKGKYAQLIQKMH-------------------KEATSDMLQDTAKIAEKPKV 754
            GTH ELM+++G+YA+LI  +                    KE+ ++  +D   I   P  
Sbjct: 683  GTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNAAMVEAFKESPAEREEDAGIIVLAPGN 742

Query: 755  E-SQALATSLEESLNGNAVPEHQLTQEEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFV 813
            E  +   +          VPEHQL Q E  +EG+++W+ YH YI+A+GGY++S    F  
Sbjct: 743  EKDEGKESETGSEFVDTKVPEHQLIQTESPQEGTVTWKTYHTYIKASGGYLLSLFTVFLF 802

Query: 814  VLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLL 873
            +L++    FS WWL  WL++GS      + N TM ++G +  +     YQ VY  + + +
Sbjct: 803  LLMIGSAAFSNWWLGLWLDKGSRMTCGPQGNRTMCEVGAVLADIGQHVYQWVYTASMVFM 862

Query: 874  ICVGVCSSGIFTKVTRKASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQL 933
            +  GV    +FTK T  AS++LH+ +F+K+ + PMSFFDT P GRL+N F+ D+++LD  
Sbjct: 863  LVFGVTKGFVFTKTTLMASSSLHDTVFDKILKSPMSFFDTTPTGRLMNRFSKDMDELDVR 922

Query: 934  LPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENY 993
            LP  +E FL    MV+ +L+I++ + P +LL+ A + V  FI   +F + +   K++EN 
Sbjct: 923  LPFHAENFLQQFFMVVFILVILAAVFPAVLLVVASLAVGFFILLRIFHRGVQELKKVENV 982

Query: 994  SRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIM 1053
            SRSP F+HI +S+QGL  IH YGK E  I+           +LL F  + RW ALR++++
Sbjct: 983  SRSPWFTHITSSMQGLGIIHAYGKKESCITY----------HLLYFNCALRWFALRMDVL 1032

Query: 1054 TNLVTLAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQ 1113
             N++T  VAL V    SS   S K ++++ ++QL+   Q   R G ET+A+FT+VE + +
Sbjct: 1033 MNILTFTVALLVTLSFSSISTSSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLRE 1092

Query: 1114 YMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGI 1173
            Y+  CV E    ++  +CP+ WP  GEI F+DY M+YRDNTP VL  +NL I+  + VGI
Sbjct: 1093 YISTCVPECTHPLKVGTCPKDWPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGI 1152

Query: 1174 VGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIR 1233
            VGRTGSGKSSLGMALFRLVEP +G I ID VDIC + LEDLR+KL+VIPQDPVL  GT+R
Sbjct: 1153 VGRTGSGKSSLGMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVR 1212

Query: 1234 FNLDPFDRHTDQQIWDALERTFL------------------------------------- 1256
            +NLDPF+ HTD+ +W  LERTF+                                     
Sbjct: 1213 YNLDPFESHTDEMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALL 1272

Query: 1257 -TKAIILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKV 1315
                IIL+DEATAS+D +TDTL+Q TI++AF+GCTVL IAHR+ TVLNCDH+LVM NGKV
Sbjct: 1273 RNSKIILLDEATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKV 1332

Query: 1316 VEFDRPEVLRKKPGSLFAALMA 1337
            +EFD+PEVL +KP S FA L+A
Sbjct: 1333 IEFDKPEVLAEKPDSAFAMLLA 1354


>gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform 1
            [Homo sapiens]
          Length = 1437

 Score =  949 bits (2453), Expect = 0.0
 Identities = 528/1360 (38%), Positives = 785/1360 (57%), Gaps = 79/1360 (5%)

Query: 60   PWGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLM-IQSLRSRLDENTIP 118
            P GKY   L  + P R   +     P+DNAGLFS +T SWL+ L  +   +  L    + 
Sbjct: 77   PKGKYHHGLSALKPIRTTSKHQ--HPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVW 134

Query: 119  PLSVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASV 178
             LS H++SD N +RL RLW+EE++  G + AS+  V+  F RTRLI   +  +   +A  
Sbjct: 135  SLSKHESSDVNCRRLERLWQEELNEVGPDAASLRRVVWIFCRTRLILSIVCLMITQLAGF 194

Query: 179  LGPILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAV 238
             GP  ++  +LEY++    N+ + + L   L L+E V+S S + +W +N RT +R R A+
Sbjct: 195  SGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTWALNYRTGVRLRGAI 254

Query: 239  SSFAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFI 298
             + AF+K+++ K++   + GE I+  + D   +FE    G L+       ++  I +  I
Sbjct: 255  LTMAFKKILKLKNIKEKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVII 314

Query: 299  IGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWE 358
            +G T F+    ++L +P  +F +R+    +      +D+R++  +EVLT IK IKMY W 
Sbjct: 315  LGPTGFLGSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWV 374

Query: 359  KPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAF 418
            K F++ ++ +R +ER++LEK G  QS+T     I+  +A+ V   +H +L   LTA+ AF
Sbjct: 375  KAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAF 434

Query: 419  SMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEE 478
            +++   N +  ++   P +VK L+ +  AV RFK  FL E           P   +  + 
Sbjct: 435  TVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKN 494

Query: 479  ATLSWQQTCPGIVNGAL---ELERNGHASEGMTRP--------RDALGPEEEGNSL---- 523
            ATL+W  +   I N      +++++  AS G              A+  E++G+ L    
Sbjct: 495  ATLAWDSSHSSIQNSPKLTPKMKKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHLLLDSD 554

Query: 524  ---GPE-----------------LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHL 563
                PE                 LH I+L + +G ++G+CG+ GSGK+SL+SAIL +M L
Sbjct: 555  ERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTL 614

Query: 564  LEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGD 623
            LEGS+ + G+ AYV QQAWI++  +R+NIL G  YD+ RY  VL+ C L  DL +LP  D
Sbjct: 615  LEGSIAISGTFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSD 674

Query: 624  MTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRG 683
            +TEIGERG NLSGGQ+QRISLARA+YSDR IY+LDDPLSA+DAHVG HIF   I+K L+ 
Sbjct: 675  LTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKS 734

Query: 684  KTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQ 743
            KTV+ VTHQLQYL  C ++I ++ G I E GTH ELM   G YA +   +    T  +  
Sbjct: 735  KTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGETPPVEI 794

Query: 744  DTAKIAEKPKVESQALATSLEESLNGNAVP--EHQLTQEEEMEEGSLSWRVYHHYIQAAG 801
            ++ K     + +SQ             AV   E QL Q EE  +GS+ W VY  YIQAAG
Sbjct: 795  NSKKETSGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQGSVPWSVYGVYIQAAG 854

Query: 802  GYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSF 861
            G +   +I    +L V  T FS WWLSYW++QGSG  +    N T     ++ DNP + +
Sbjct: 855  GPLAFLVIMALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETSVS-DSMKDNPHMQY 913

Query: 862  YQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLFNKVFRCPMSFFDTIPIGRLLN 921
            Y  +Y L+  +++ +      +F K T +AS+ LH++LF ++ R PM FFDT P GR+LN
Sbjct: 914  YASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILN 973

Query: 922  CFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFK 981
             F+ D++++D  LP  +E F+   ++V   + +++ + P+ L+    ++++  + +++ +
Sbjct: 974  RFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSR 1033

Query: 982  KAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLS 1041
              I   KRL+N ++SP  SHI +S+QGL++IH Y K ++F+ +++ L D       LF  
Sbjct: 1034 VLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTC 1093

Query: 1042 STRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLET 1101
            + RW+A+RL++++  +     L +       P ++  +A++  +QL   FQ T R+  ET
Sbjct: 1094 AMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLASET 1153

Query: 1102 EAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGI 1161
            EA+FT+VERI  Y+K    EAP  ++  +    WPQ GE+ F++  M+YR+N P VL  +
Sbjct: 1154 EARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVLKKV 1213

Query: 1162 NLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVI 1221
            + TI+  E +GIVGRTGSGKSSLGMALFRLVE   G I IDGV I  IGL DLRSKLS+I
Sbjct: 1214 SFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSII 1273

Query: 1222 PQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKA---------------------- 1259
            PQ+PVL SGT+R NLDPF+++T+ QIWDALERT + +                       
Sbjct: 1274 PQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVG 1333

Query: 1260 ----------------IILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLN 1303
                            I+++DEATA++D ETD LIQ TIREAF  CT+L IAHR+ TVL 
Sbjct: 1334 ERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLG 1393

Query: 1304 CDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATATSSL 1343
             D I+V+  G+VVEFD P VL     S F A+ A A + +
Sbjct: 1394 SDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAAAENKV 1433


>gi|157502201 ATP-binding cassette, sub-family C, member 4 isoform 1
            [Homo sapiens]
          Length = 1325

 Score =  640 bits (1651), Expect = 0.0
 Identities = 433/1317 (32%), Positives = 669/1317 (50%), Gaps = 124/1317 (9%)

Query: 83   PQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEEVS 142
            P PL +A L S +   WL PL     + RL+E+ +  +   D S    + L   W++EV 
Sbjct: 10   PNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVL 69

Query: 143  R--RGIEKASVLLVMLR-FQRTRLIFDALLGICFCI---ASVLGPILIIPKILEYSE--E 194
            R     +K S+   +++ + ++ L+    LGI   I   A V+ PI +  KI+ Y E  +
Sbjct: 70   RAENDAQKPSLTRAIIKCYWKSYLV----LGIFTLIEESAKVIQPIFL-GKIINYFENYD 124

Query: 195  QLGNVVHGVGLCFALFLSECVKSLSFSSSWIIN--QRTAIRFRAAVSSFAFEKLIQFKSV 252
             + +V       +A  L+ C   L+          Q   +R R A+    + K ++  ++
Sbjct: 125  PMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNM 184

Query: 253  I--HITSGEAISFFTGDVNYLFEGVCY------GPLVLITCASLVICSISSYFIIGYTAF 304
                 T+G+ ++  + DVN   +   +      GPL  I   +L+      +  IG +  
Sbjct: 185  AMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALL------WMEIGISCL 238

Query: 305  IAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKI 364
              +   +++ PL     ++    +  T+  +D RIR  +EV+T I++IKMY WEK F+ +
Sbjct: 239  AGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNL 298

Query: 365  IEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLASL 424
            I +LR+KE   + +   ++ +   + F    +   V    +  L   +TAS  F  +   
Sbjct: 299  ITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLY 358

Query: 425  NLLRLSV-FFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVF-EEATLS 482
              +RL+V  F P A++ ++ +  ++ R + F L +      + L    K +V  ++ T  
Sbjct: 359  GAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAF 418

Query: 483  WQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLGV 542
            W +                 ASE                   P L  ++  V  G +L V
Sbjct: 419  WDK-----------------ASET------------------PTLQGLSFTVRPGELLAV 443

Query: 543  CGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKAR 602
             G  G+GKSSLLSA+L E+    G V V G +AYV QQ W+ SG +R NIL G  Y+K R
Sbjct: 444  VGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKER 503

Query: 603  YLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLS 662
            Y +V+  C+L +DL+LL  GD+T IG+RG  LSGGQK R++LARAVY D  IYLLDDPLS
Sbjct: 504  YEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLS 563

Query: 663  AVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQK 722
            AVDA V +H+FE CI + L  K  +LVTHQLQYL+   QI++L++GK+ + GT++E ++ 
Sbjct: 564  AVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKS 623

Query: 723  KGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALA-TSLEESLNGNAVPEHQLTQ-- 779
               +  L++K ++E+    +  T  +  +   ES   +  S   SL   A+ E Q T+  
Sbjct: 624  GIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGAL-ESQDTENV 682

Query: 780  -----EEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQG 834
                 EE   EG + ++ Y +Y +A   ++V   +           +   WWLSYW    
Sbjct: 683  PVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYW---- 738

Query: 835  SGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTA 894
               N     N T+   GN+ +   L++Y  +Y    +  +  G+  S +   V   +S  
Sbjct: 739  --ANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQT 796

Query: 895  LHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLI 954
            LHNK+F  + + P+ FFD  PIGR+LN F+ D+  LD LLP+    F+   L V+ V+ +
Sbjct: 797  LHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSV 856

Query: 955  VSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHV 1014
               + P+I +    + +I       F +     KRLE+ +RSP+FSH+ +SLQGL +I  
Sbjct: 857  AVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRA 916

Query: 1015 YGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPY 1074
            Y   E     F    D  +    LFL+++RW A+RL+ +  +  + VA F +  ++ T  
Sbjct: 917  YKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVA-FGSLILAKTLD 975

Query: 1075 SFKV-MAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQ 1133
            + +V +A++  L L   FQ   R   E E    +VER+++Y  +   EAP   +    P 
Sbjct: 976  AGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDL-EKEAPWEYQKRP-PP 1033

Query: 1134 GWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVE 1193
             WP  G IIF + +  Y    P VL  +   I+  E VGIVGRTG+GKSSL  ALFRL E
Sbjct: 1034 AWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSE 1093

Query: 1194 PMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALE- 1252
            P  G+I ID +    IGL DLR K+S+IPQ+PVL +GT+R NLDPF+ HTD+++W+AL+ 
Sbjct: 1094 P-EGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQE 1152

Query: 1253 ------------------------------------RTFLTK-AIILIDEATASIDMETD 1275
                                                R  L K  I++IDEATA++D  TD
Sbjct: 1153 VQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTD 1212

Query: 1276 TLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLF 1332
             LIQ+ IRE F  CTVL IAHR+ T+++ D I+V+ +G++ E+D P VL +   SLF
Sbjct: 1213 ELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLF 1269



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 65/238 (27%), Positives = 119/238 (50%), Gaps = 23/238 (9%)

Query: 527  LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMH---------LLEGSVGVQG---SL 574
            L  +  ++     +G+ G TG+GKSSL+SA+              +L   +G+      +
Sbjct: 1058 LKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKM 1117

Query: 575  AYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNL 634
            + +PQ+  + +G +R+N+     +        L    L   +E LP    TE+ E G N 
Sbjct: 1118 SIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNF 1177

Query: 635  SGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGK----TVVLVT 690
            S GQ+Q + LARA+    QI ++D+  + VD        +E I+K +R K    TV+ + 
Sbjct: 1178 SVGQRQLVCLARAILRKNQILIIDEATANVDPRT-----DELIQKKIREKFAHCTVLTIA 1232

Query: 691  HQLQYLEFCGQIILLENGKICENGTHSELMQ-KKGKYAQLIQKMHKEATSDMLQDTAK 747
            H+L  +    +I++L++G++ E      L+Q K+  + +++Q++ K A +  L +TAK
Sbjct: 1233 HRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQQLGK-AEAAALTETAK 1289


>gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform 1
            [Homo sapiens]
          Length = 1527

 Score =  620 bits (1599), Expect = e-177
 Identities = 442/1381 (32%), Positives = 657/1381 (47%), Gaps = 196/1381 (14%)

Query: 74   FRPKPRF-------PAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDAS 126
            FR KP F       P P P  +AG  S L   W T + I   R  L+E  +  L   D S
Sbjct: 190  FREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRS 249

Query: 127  DKNVQRLHRLWEEEVSRRGIEKAS------------VLLVMLRFQRTRLIFDALLGICFC 174
               VQ+L   W ++  +    KAS            VLL      R      ALL     
Sbjct: 250  QMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGS 309

Query: 175  IASVLGPILIIPKILEYSEEQLGNVV------------HGVGLCFALFLSECVKSLSFSS 222
               +     +I  +L +   QL +++             G  +   +FL   ++SL    
Sbjct: 310  SFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQH 369

Query: 223  SWIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPL 280
             +     T ++FR  +    + K +   + +   S  GE ++  + D     +   +  L
Sbjct: 370  YYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPF--L 427

Query: 281  VLITCASLVICSISSYFI---IGYTAFIAILCYLLVFPL----AVFMTRMAVKAQHHTSE 333
             L+  A L I  ++ YF+   +G +    +   +L+ PL    AV M    VK      +
Sbjct: 428  NLLWSAPLQII-LAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQM----K 482

Query: 334  VSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFII 393
            + D RI++ SE+L  IK++K+Y WE  F K +E +R+ E +LL     + + T+ T    
Sbjct: 483  LKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCS 542

Query: 394  PTVATAV--WVLIHTSLKLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRF 451
            P + T +  WV ++      L A  AF  ++  N+LRL +  +P  +  LT +  ++ R 
Sbjct: 543  PFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRI 602

Query: 452  KKFFLQES--PVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTR 509
            ++F  QE   P    +    P  A+     T +W Q  P                     
Sbjct: 603  QQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLP--------------------- 641

Query: 510  PRDALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVG 569
                           P LH +++ V KG ++ V G  G GKSSL+SA+L EM  LEG V 
Sbjct: 642  ---------------PTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVH 686

Query: 570  VQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGE 629
            ++GS+AYVPQQAWI +  ++EN+L G A +  RY Q L  C+L  DLE+LP GD TEIGE
Sbjct: 687  MKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGE 746

Query: 630  RGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECI--KKTLRGKTVV 687
            +G+NLSGGQ+QR+SLARAVYSD  I+LLDDPLSAVD+HV KHIF+  I  +  L GKT V
Sbjct: 747  KGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRV 806

Query: 688  LVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDT-- 745
            LVTH + +L     II+L +G++ E G +  L+Q+ G +A  +     +     L+D+  
Sbjct: 807  LVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWT 866

Query: 746  ----AKIAEKPKVES------------------------QALATSLEESLNGNAVPEHQL 777
                A+  E   +E                         Q  A S +    G  VP   L
Sbjct: 867  ALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHL 926

Query: 778  -----------------TQEEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLT 820
                             TQEE+   G++   V+  Y +A G      I   +V       
Sbjct: 927  GPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLAICLLYVGQSA-AA 985

Query: 821  IFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALL--LICVGV 878
            I +  WLS W            +N  MAD      + +L  Y  +  L   L  L  + +
Sbjct: 986  IGANVWLSAW------------TNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAM 1033

Query: 879  CSSGIFTKVTRKASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFS 938
             + GI      +A+  LH  L +   R P SFFDT P GR+LNCF+ D+  +D++L    
Sbjct: 1034 AAGGI------QAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVI 1087

Query: 939  EQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPL 998
               L      I+ L+++   +P   ++   + V+  +    +       KRLE+ SRSP+
Sbjct: 1088 LMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPI 1147

Query: 999  FSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVT 1058
            +SH   ++ G S I  Y ++ DF        DA       ++ S RW+++ +E + N V 
Sbjct: 1148 YSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVV 1207

Query: 1059 LAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMC 1118
            L  ALF   G SS       ++V+  LQ+  +     R+  + E+   AVER+ +Y K  
Sbjct: 1208 LFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKT- 1266

Query: 1119 VSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTG 1178
             +EAP  +EG+  P+GWP  GE+ F++Y ++YR     VL  ++L + G E VGIVGRTG
Sbjct: 1267 ETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTG 1326

Query: 1179 SGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDP 1238
            +GKSS+ + LFR++E   G I IDG+++  IGL DLRS+L++IPQDP+L SGT+R NLDP
Sbjct: 1327 AGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDP 1386

Query: 1239 FDRHTDQQIWDALE-------------------------------------RTFLTKA-I 1260
            F  ++++ IW ALE                                     R  L K+ I
Sbjct: 1387 FGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRI 1446

Query: 1261 ILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDR 1320
            +++DEATA+ID+ETD LIQ TIR  F  CTVL IAHR+ T+++   +LV+  G V EFD 
Sbjct: 1447 LVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDS 1506

Query: 1321 P 1321
            P
Sbjct: 1507 P 1507



 Score = 80.9 bits (198), Expect = 8e-15
 Identities = 54/211 (25%), Positives = 100/211 (47%), Gaps = 14/211 (6%)

Query: 527  LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
            L  ++L V  G  +G+ G TG+GKSS+   +   +   +G + + G              
Sbjct: 1306 LRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQ 1365

Query: 574  LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLN 633
            L  +PQ   + SG +R N+   G+Y +      L    L+  +   P G   +  E G N
Sbjct: 1366 LTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGEN 1425

Query: 634  LSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQL 693
            LS GQ+Q + LARA+    +I +LD+  +A+D     ++ +  I+      TV+ + H+L
Sbjct: 1426 LSVGQRQLVCLARALLRKSRILVLDEATAAIDLET-DNLIQATIRTQFDTCTVLTIAHRL 1484

Query: 694  QYLEFCGQIILLENGKICENGTHSELMQKKG 724
              +    ++++L+ G + E  + + L+  +G
Sbjct: 1485 NTIMDYTRVLVLDKGVVAEFDSPANLIAARG 1515


>gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
            [Homo sapiens]
          Length = 1545

 Score =  591 bits (1524), Expect = e-168
 Identities = 390/1229 (31%), Positives = 625/1229 (50%), Gaps = 171/1229 (13%)

Query: 209  LFLSECVKSLSFSSSWIINQRTAIRFRAAVSSFAFEKLIQFKSVIH--ITSGEAISFFTG 266
            LF +  ++S      + +  +  ++ R A+ +  ++K +   ++     T GE ++  + 
Sbjct: 367  LFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLMSV 426

Query: 267  DVNYLFEGVCYGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVK 326
            D   L +   +  ++  +   +V+     +  +G +    +   +LV P+   ++  +  
Sbjct: 427  DAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKT 486

Query: 327  AQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLT 386
             Q    +  D+R+++ +E+L+ IK++K + WE  F   +++LR+KE K L     +Q + 
Sbjct: 487  IQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVV 546

Query: 387  ----SITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLT 442
                 +T  ++  V  +V+VL+ ++  L   A  AF+ +   N+LR  +  +P+ +  + 
Sbjct: 547  IFVFQLTPVLVSVVTFSVYVLVDSNNILD--AQKAFTSITLFNILRFPLSMLPMMISSML 604

Query: 443  NSKSAVMRFKKFF----LQESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALELE 498
             +  +  R +K+     L  S + +        KA+ F EA+ +W+              
Sbjct: 605  QASVSTERLEKYLGGDDLDTSAIRHDCNFD---KAMQFSEASFTWE-------------- 647

Query: 499  RNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAIL 558
               H SE   R                    +NL +  G ++ V G  GSGKSSL+SA+L
Sbjct: 648  ---HDSEATVRD-------------------VNLDIMAGQLVAVIGPVGSGKSSLISAML 685

Query: 559  EEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLEL 618
             EM  + G + ++G+ AYVPQQ+WI +G I++NIL G  +++ RY QVL  C+L  DLE+
Sbjct: 686  GEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLPDLEM 745

Query: 619  LPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIK 678
            LP GD+ EIGE+G+NLSGGQKQRISLARA Y +  IYLLDDPLSAVDAHVGKHIF + + 
Sbjct: 746  LPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLG 805

Query: 679  KT--LRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKM--- 733
                L+GKT +LVTH + +L    +I++L NG I E G++S L+ KKG++A+ ++     
Sbjct: 806  PNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKTFLRH 865

Query: 734  ---HKEAT------------------SDMLQDTAKIAEKPKVESQALAT----------- 761
                +EAT                   ++ +D A I  + +   +   +           
Sbjct: 866  TGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAASITMRRENSFRRTLSRSSRSNGRHLK 925

Query: 762  SLEESL---NGNAVPEHQ-------LTQEEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFF 811
            SL  SL   N N++ E +       L ++E +E G + + +Y  Y+QA G + +  II  
Sbjct: 926  SLRNSLKTRNVNSLKEDEELVKGQKLIKKEFIETGKVKFSIYLEYLQAIGLFSIFFIILA 985

Query: 812  FVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNP--QLSFYQLVYGLN 869
            FV+  V   I S  WLS W      T+ S+  N T        D P  Q      VYG  
Sbjct: 986  FVMNSVAF-IGSNLWLSAW------TSDSKIFNST--------DYPASQRDMRVGVYGAL 1030

Query: 870  ALLLICVGVCSSGIFTKVTR--------KASTALHNKLFNKVFRCPMSFFDTIPIGRLLN 921
             L        + GIF  +           AS  LH +L N + R PM FFDT P GR++N
Sbjct: 1031 GL--------AQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIVN 1082

Query: 922  CFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFK 981
             FAGD+  +D  LP     ++   L +I+ L+++ + +P   ++   + +I     M + 
Sbjct: 1083 RFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFYV 1142

Query: 982  KAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLS 1041
                  +RL++ +RSP++SH   ++ GL  I  +   + F+   +   D     +  +++
Sbjct: 1143 STSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWIT 1202

Query: 1042 STRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLET 1101
            S RW+A+RLE++ NL     AL +     +         ++  L +  +     R+  E 
Sbjct: 1203 SNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMTSEI 1262

Query: 1102 EAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGI 1161
            E    AVERI +Y K+  +EAP   +    P  WP  G+I F +Y ++YR     VL GI
Sbjct: 1263 ETNIVAVERITEYTKV-ENEAPWVTDKRP-PPDWPSKGKIQFNNYQVRYRPELDLVLRGI 1320

Query: 1162 NLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVI 1221
               I   E +G+VGRTG+GKSSL   LFR++E   G+I+IDGVDI SIGL DLR KL++I
Sbjct: 1321 TCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTII 1380

Query: 1222 PQDPVLLSGTIRFNLDPFDRHTDQQIWDALE----------------------------- 1252
            PQDP+L SG++R NLDPF+ ++D++IW ALE                             
Sbjct: 1381 PQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIG 1440

Query: 1253 --------RTFLTKA-IILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLN 1303
                    R  L K+ I+++DEATA++D+ETD LIQ TI+  F  CTV+ IAHR+ T+++
Sbjct: 1441 QRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMD 1500

Query: 1304 CDHILVMGNGKVVEFDRPEVLRKKPGSLF 1332
             D ++V+ NGK++E   PE L + PG  +
Sbjct: 1501 SDKVMVLDNGKIIECGSPEELLQIPGPFY 1529


>gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1
            [Homo sapiens]
          Length = 1531

 Score =  588 bits (1516), Expect = e-167
 Identities = 404/1376 (29%), Positives = 668/1376 (48%), Gaps = 180/1376 (13%)

Query: 81   PAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEE 140
            P P P  +A   S +T  W+T L+++  R  L+ + +  L+  D S++ V  L + W++E
Sbjct: 205  PNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKE 264

Query: 141  VSRRGIEKASVL-----------------------LVMLRFQR--TRLIFDAL---LGIC 172
             ++   +   V+                       L++   Q+     +F  L    G  
Sbjct: 265  CAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPY 324

Query: 173  FCIASVLGPI---------LIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSS 223
            F ++     I          I+  ++++  +       G      LF++ C+++L     
Sbjct: 325  FLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQY 384

Query: 224  WIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPLV 281
            + I   + +R + AV    + K +   +    +S  GE ++  + D     +   Y  ++
Sbjct: 385  FHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMI 444

Query: 282  LITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRV 341
                  +++     +  +G +    +   +L+ P+   M       Q    +  D RI++
Sbjct: 445  WSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKL 504

Query: 342  TSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVW 401
             +E+L  IK++K+Y WE  F   +  +R++E K+L+K   + ++ + T    P +     
Sbjct: 505  MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCT 564

Query: 402  VLIHTSLKLK--LTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQES 459
              ++ ++     L A  AF  LA  N+LR  +  +P+ +  +  +  ++ R + F   E 
Sbjct: 565  FAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEE 624

Query: 460  ---PVFYVQTLQDP--SKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRDAL 514
                    + ++D   + ++    AT +W ++ P  +NG                     
Sbjct: 625  LEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNG--------------------- 663

Query: 515  GPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSL 574
                           I   + +G ++ V G  G GKSSLLSA+L EM  +EG V ++GS+
Sbjct: 664  ---------------ITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSV 708

Query: 575  AYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNL 634
            AYVPQQAWI + ++RENIL G   ++  Y  V+  C+L  DLE+LP GD TEIGE+G+NL
Sbjct: 709  AYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNL 768

Query: 635  SGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECI--KKTLRGKTVVLVTHQ 692
            SGGQKQR+SLARAVYS+  IYL DDPLSAVDAHVGKHIFE  I  K  L+ KT +LVTH 
Sbjct: 769  SGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHS 828

Query: 693  LQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAKIA--- 749
            + YL     II++  GKI E G++ EL+ + G +A+ ++     A+++  QD  +     
Sbjct: 829  MSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTY---ASTEQEQDAEENGVTG 885

Query: 750  ------EKPKVESQALAT-----------SLEESLNGNAVPEHQLTQE------------ 780
                  E  ++E+  L T           S   S +G+    H  T E            
Sbjct: 886  VSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETW 945

Query: 781  -----EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGS 835
                 ++ + G +   VY  Y++A G ++    IF F+   V   + S +WLS W +   
Sbjct: 946  KLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHV-SALASNYWLSLWTDDPI 1004

Query: 836  GTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTAL 895
               +   +   ++  G +  +  ++    V+G +      + V   GI       AS  L
Sbjct: 1005 VNGTQEHTKVRLSVYGALGISQGIA----VFGYS------MAVSIGGIL------ASRCL 1048

Query: 896  HNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIV 955
            H  L + + R PMSFF+  P G L+N F+ +L+ +D ++P   + F+     VI   +++
Sbjct: 1049 HVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVI 1108

Query: 956  SVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVY 1015
             + +P   ++   + +I F     +  +    KRLE+ SRSP++SH   +L G+S I  +
Sbjct: 1109 LLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAF 1168

Query: 1016 GKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYS 1075
             + E FI Q     D         + + RW+A+RLE + N + L  ALF      S    
Sbjct: 1169 EEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAG 1228

Query: 1076 FKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGW 1135
               ++V+  LQ+ +      R+  E E    AVER+ +Y +    EAP  ++ T+ P  W
Sbjct: 1229 LVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSE-TEKEAPWQIQETAPPSSW 1287

Query: 1136 PQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPM 1195
            PQ G + F++Y ++YR++   VL  IN+TI G E VGIVGRTG+GKSSL + LFR+ E  
Sbjct: 1288 PQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESA 1347

Query: 1196 AGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALE--- 1252
             G I+IDG++I  IGL DLR K+++IPQDPVL SG++R NLDPF +++D+++W +LE   
Sbjct: 1348 EGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAH 1407

Query: 1253 ----------------------------------RTFLTKA-IILIDEATASIDMETDTL 1277
                                              R  L K  I+++DEATA++D+ETD L
Sbjct: 1408 LKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDL 1467

Query: 1278 IQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFA 1333
            IQ TIR  F+ CTVL IAHR+ T+++   ++V+  G++ E+  P  L ++ G  ++
Sbjct: 1468 IQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYS 1523



 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 65/224 (29%), Positives = 105/224 (46%), Gaps = 18/224 (8%)

Query: 527  LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
            L  IN+ ++ G  +G+ G TG+GKSSL   +       EG + + G              
Sbjct: 1310 LRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFK 1369

Query: 574  LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLN 633
            +  +PQ   + SG++R N+     Y        L    L   +  LP     E  E G N
Sbjct: 1370 ITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGEN 1429

Query: 634  LSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQL 693
            LS GQ+Q + LARA+    +I +LD+  +AVD      + +  I+      TV+ + H+L
Sbjct: 1430 LSVGQRQLVCLARALLRKTKILVLDEATAAVDLET-DDLIQSTIRTQFEDCTVLTIAHRL 1488

Query: 694  QYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEA 737
              +    ++I+L+ G+I E G  S+L+Q++G    L   M K+A
Sbjct: 1489 NTIMDYTRVIVLDKGEIQEYGAPSDLLQQRG----LFYSMAKDA 1528


>gi|134142335 ATP-binding cassette, sub-family C, member 1 isoform 5
            [Homo sapiens]
          Length = 1466

 Score =  537 bits (1383), Expect = e-152
 Identities = 370/1261 (29%), Positives = 613/1261 (48%), Gaps = 142/1261 (11%)

Query: 81   PAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEE 140
            P P P  +A   S +T  W+T L+++  R  L+ + +  L+  D S++ V  L + W++E
Sbjct: 205  PNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKE 264

Query: 141  VSRRGIEKASVL-----------------------LVMLRFQR--TRLIFDAL---LGIC 172
             ++   +   V+                       L++   Q+     +F  L    G  
Sbjct: 265  CAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPY 324

Query: 173  FCIASVLGPI---------LIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSS 223
            F ++     I          I+  ++++  +       G      LF++ C+++L     
Sbjct: 325  FLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQY 384

Query: 224  WIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPLV 281
            + I   + +R + AV    + K +   +    +S  GE ++  + D     +   Y  ++
Sbjct: 385  FHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMI 444

Query: 282  LITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRV 341
                  +++     +  +G +    +   +L+ P+   M       Q    +  D RI++
Sbjct: 445  WSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKL 504

Query: 342  TSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVW 401
             +E+L  IK++K+Y WE  F   +  +R++E K+L+K   + ++ + T    P +     
Sbjct: 505  MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCT 564

Query: 402  VLIHTSLKLK--LTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQES 459
              ++ ++     L A  AF  LA  N+LR  +  +P+ +  +  +  ++ R + F   E 
Sbjct: 565  FAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEE 624

Query: 460  ---PVFYVQTLQDP--SKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRDAL 514
                    + ++D   + ++    AT +W ++ P  +NG                     
Sbjct: 625  LEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNG--------------------- 663

Query: 515  GPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSL 574
                           I   + +G ++ V G  G GKSSLLSA+L EM  +EG V ++GS+
Sbjct: 664  ---------------ITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSV 708

Query: 575  AYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNL 634
            AYVPQQAWI + ++RENIL G   ++  Y  V+  C+L  DLE+LP GD TEIGE+G+NL
Sbjct: 709  AYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNL 768

Query: 635  SGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECI--KKTLRGKTVVLVTHQ 692
            SGGQKQR+SLARAVYS+  IYL DDPLSAVDAHVGKHIFE  I  K  L+ KT +LVTH 
Sbjct: 769  SGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHS 828

Query: 693  LQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAKIA--- 749
            + YL     II++  GKI E G++ EL+ + G +A+ ++     A+++  QD  +     
Sbjct: 829  MSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTY---ASTEQEQDAEENGVTG 885

Query: 750  ------EKPKVESQALAT-----------SLEESLNGNAVPEHQLTQE------------ 780
                  E  ++E+  L T           S   S +G+    H  T E            
Sbjct: 886  VSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETW 945

Query: 781  -----EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGS 835
                 ++ + G +   VY  Y++A G ++    IF F+   V   + S +WLS W +   
Sbjct: 946  KLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHV-SALASNYWLSLWTDDPI 1004

Query: 836  GTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTAL 895
               +   +   ++  G +  +  ++    V+G +      + V   GI       AS  L
Sbjct: 1005 VNGTQEHTKVRLSVYGALGISQGIA----VFGYS------MAVSIGGIL------ASRCL 1048

Query: 896  HNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIV 955
            H  L + + R PMSFF+  P G L+N F+ +L+ +D ++P   + F+     VI   +++
Sbjct: 1049 HVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVI 1108

Query: 956  SVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVY 1015
             + +P   ++   + +I F     +  +    KRLE+ SRSP++SH   +L G+S I  +
Sbjct: 1109 LLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAF 1168

Query: 1016 GKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYS 1075
             + E FI Q     D         + + RW+A+RLE + N + L  ALF      S    
Sbjct: 1169 EEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAG 1228

Query: 1076 FKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGW 1135
               ++V+  LQ+ +      R+  E E    AVER+ +Y +    EAP  ++ T+ P  W
Sbjct: 1229 LVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSE-TEKEAPWQIQETAPPSSW 1287

Query: 1136 PQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPM 1195
            PQ G + F++Y ++YR++   VL  IN+TI G E VGIVGRTG+GKSSL + LFR+ E  
Sbjct: 1288 PQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESA 1347

Query: 1196 AGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTF 1255
             G I+IDG++I  IGL DLR K+++IPQDPVL SG++R NLDPF +++D+++W +LE   
Sbjct: 1348 EGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAH 1407

Query: 1256 L 1256
            L
Sbjct: 1408 L 1408



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 32/121 (26%), Positives = 48/121 (39%), Gaps = 13/121 (10%)

Query: 527  LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
            L  IN+ ++ G  +G+ G TG+GKSSL   +       EG + + G              
Sbjct: 1310 LRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFK 1369

Query: 574  LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLN 633
            +  +PQ   + SG++R N+     Y        L    L   +  LP     E  E G N
Sbjct: 1370 ITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGEN 1429

Query: 634  L 634
            L
Sbjct: 1430 L 1430


>gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo
            sapiens]
          Length = 1464

 Score =  524 bits (1349), Expect = e-148
 Identities = 412/1372 (30%), Positives = 649/1372 (47%), Gaps = 178/1372 (12%)

Query: 73   PFRPKPRFPAPQPL----DNAGLFSYLTVSWLTPLMIQS----LRSRLDENTIP----PL 120
            P+  +P  P  Q      D     S  + +WL PL+ +     LR   D   +P    P 
Sbjct: 155  PWAQEPLLPEDQEPEVAEDGESWLSRFSYAWLAPLLARGACGELRQPQDICRLPHRLQPT 214

Query: 121  SVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLG 180
             +      + Q   RLW       G  +  + L +L+   T L F              G
Sbjct: 215  YLARVFQAHWQEGARLWRALYGAFG--RCYLALGLLKLVGTMLGFS-------------G 259

Query: 181  PILI--IPKILEYSEEQLGN-VVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAA 237
            P+L+  +   LE  +E L + +++ +GL     L   +++      +    +  ++ R A
Sbjct: 260  PLLLSLLVGFLEEGQEPLSHGLLYALGLAGGAVLGAVLQNQYGYEVY----KVTLQARGA 315

Query: 238  VSSFAFEKLIQFKSVIHITSGEAISFFTGDVNYL--FEGVCYG----PLVLITCASLVIC 291
            V +  + K +Q        +GEA++    D   L  F G  +     PL L     L+  
Sbjct: 316  VLNILYCKALQL-GPSRPPTGEALNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQ 374

Query: 292  SISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKL 351
             +   F+ G      IL  LLV    V  TR+    Q       D R+++ +E+L+ I++
Sbjct: 375  QVGVAFVGGL-----ILALLLVPVNKVIATRIMASNQEMLQH-KDARVKLVTELLSGIRV 428

Query: 352  IKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFI---IPTVATAVWVLIHTSL 408
            IK   WE+     +E  R +E   L +  +++ L +  +++   +P V + V  + +  +
Sbjct: 429  IKFCGWEQALGARVEACRARE---LGRLRVIKYLDAACVYLWAALPVVISIVIFITYVLM 485

Query: 409  KLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQ 468
              +LTA+  F+ LA + +L L +   P  + GL  +K ++ R + F   + P    Q   
Sbjct: 486  GHQLTATKVFTALALVRMLILPLNNFPWVINGLLEAKVSLDRIQLFL--DLPNHNPQAYY 543

Query: 469  DPSKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELH 528
             P    +   A + W          +  LE +G               +  G SL  E  
Sbjct: 544  SPDCGRL--GAQIKWLLCSDPPAEPSTVLELHG----------ALFSWDPVGTSL--ETF 589

Query: 529  KINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG---SLAYVPQQAWIVS 585
              +L V KGM++G+ G  G GKSSLL+AI  E+H L G V V+G         Q+ WI  
Sbjct: 590  ISHLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKGFGLATQEPWIQF 649

Query: 586  GNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLA 645
              IR+NIL G  +D   Y +VL  C+LN DL +LP GD TE+GE+G+ LSGGQ+ RI+LA
Sbjct: 650  ATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALA 709

Query: 646  RAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILL 705
            RAVY ++++YLLDDPL+AVDA V  H+   CI   L   T +L TH+ +YLE    ++L+
Sbjct: 710  RAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTEYLERADAVLLM 769

Query: 706  ENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEE 765
            E G++   G  SE++       Q + K   E   +    TA+  + P+   + L    E+
Sbjct: 770  EAGRLIRAGPPSEIL----PLVQAVPKAWAENGQESDSATAQSVQNPEKTKEGLEE--EQ 823

Query: 766  SLNGNAVPEHQLTQEEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFW 825
            S +G      +L QEE  +EG+++  VY  Y +A G  +   I+ F ++L+      + W
Sbjct: 824  STSG------RLLQEESKKEGAVALHVYQAYWKAVGQGLALAIL-FSLLLMQATRNAADW 876

Query: 826  WLSYWLEQGSGTNSSRESNGTMADLGNIADNPQL-------------------------- 859
            WLS+W+ Q    NSS+E+  + +       +PQL                          
Sbjct: 877  WLSHWISQLKAENSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDI 936

Query: 860  SFYQLVY----GLNALLLICVGVCSSGIFTKVTRKASTALHNKLFNKVFRCPMSFFDTIP 915
             FY  VY    G+N+L  +   V    +F   T +A+  LH +L ++V   P++FF+  P
Sbjct: 937  RFYLTVYATIAGVNSLCTLLRAV----LFAAGTLQAAATLHRRLLHRVLMAPVTFFNATP 992

Query: 916  IGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFI 975
             GR+LN F+ D+   D  LP      L  +  ++ +L ++    P++LL+   + ++ + 
Sbjct: 993  TGRILNRFSSDVACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYH 1052

Query: 976  YYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNY 1035
                ++ +    +RL + + SPL+SH+ ++L GLS +   G T  F  +  RL +     
Sbjct: 1053 VQRHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRC 1112

Query: 1036 LLLFLSSTRWMALRLEIMTNLVTLAVALFVAF---------GISSTPYSFKVMAVNIVLQ 1086
                 ++ +W+ +RL++M   V  A+A              G+     S+ +    ++  
Sbjct: 1113 QFATSATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSG 1172

Query: 1087 LASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEG--TSCPQGWPQHGEIIFQ 1144
            L SSF        +TEA   +VER+ +Y      + P   +G       GW   G + FQ
Sbjct: 1173 LVSSF-------TQTEAMLVSVERLEEY----TCDLPQEPQGQPLQLGTGWLTQGGVEFQ 1221

Query: 1145 DYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGV 1204
            D  + YR   P  L G+   ++  E +GIVGRTGSGKSSL + LFRL+EP +GR+L+DGV
Sbjct: 1222 DVVLAYRPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGV 1281

Query: 1205 DICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALE------------ 1252
            D   + L  LRS+L++IPQ+P L SGT+R NLDP   H D+ +W AL+            
Sbjct: 1282 DTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITSMG 1341

Query: 1253 ------------------------RTFLTKA-IILIDEATASIDMETDTLIQRTIREAFQ 1287
                                    R  LT A I+ IDEATAS+D +TD L+Q+TI + F 
Sbjct: 1342 GLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFA 1401

Query: 1288 GCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATA 1339
              TVL IAHR+ T+LN D +LV+  G+VVE D P  LR +P SLF  L+ ++
Sbjct: 1402 NKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLLQSS 1453


>gi|190343023 ATP-binding cassette, sub-family C, member 6 isoform 1
            [Homo sapiens]
          Length = 1503

 Score =  519 bits (1336), Expect = e-147
 Identities = 402/1373 (29%), Positives = 631/1373 (45%), Gaps = 182/1373 (13%)

Query: 73   PFRPK-PRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQ 131
            PF P+ P+   P P   A   S  T  W++ L+ +  R  L    +  L   ++S++ V 
Sbjct: 191  PFFPEDPQQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVS 250

Query: 132  RLHRLWEEEVS------------RRGIE--KASVLLVMLRFQRT--RLIFDALLGICFCI 175
            RL + W    S            R+G    KA      LR + +  R +  A+  + F  
Sbjct: 251  RLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQV-FHS 309

Query: 176  ASVLGPILII---------PKILEYSEEQLGN----VVHGVGLCFALFLSECVKSLSFSS 222
              +LG + +I         PK+L    E +G+       G  L   +FLS C+++L    
Sbjct: 310  TFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQ 369

Query: 223  SWIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPL 280
            +    +   +R R+A++   + K++   S     S  G+ ++  + DV  L E V Y   
Sbjct: 370  NMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNG 429

Query: 281  VLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEV---SDQ 337
            + +    +V+C +  + ++G +A  AI  +L + PL  F+++   K  HH  E     D 
Sbjct: 430  LWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISK---KRNHHQEEQMRQKDS 486

Query: 338  RIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVA 397
            R R+TS +L   K IK + WE  F   +  +R +E   L   GL+ S++ ++  +   + 
Sbjct: 487  RARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLV 546

Query: 398  TAVWVLIHTSL-KLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFF- 455
              V   +HT + +  + A  AF  L  LN+L  +  F+P ++  L  ++ +  R   F  
Sbjct: 547  ALVVFAVHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLC 606

Query: 456  LQESPVFYVQTLQDPSKA----LVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPR 511
            L+E     V +    S A    +    AT +W Q  P                       
Sbjct: 607  LEEVDPGVVDSSSSGSAAGKDCITIHSATFAWSQESP----------------------- 643

Query: 512  DALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQ 571
                         P LH+INL V +G +L V G  G+GKSSLLSA+L E+  +EG V ++
Sbjct: 644  -------------PCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIE 690

Query: 572  GSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERG 631
            G++AYVPQ+AW+ + ++ EN+  G   D     +VL  C+L  D++  P G  T IGE+G
Sbjct: 691  GAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQG 750

Query: 632  LNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKK--TLRGKTVVLV 689
            +NLSGGQKQR+SLARAVY    +YLLDDPL+A+DAHVG+H+F + I     L+G T +LV
Sbjct: 751  MNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILV 810

Query: 690  THQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEA-TSDMLQDTAKI 748
            TH L  L     II+L NG I E G++ EL+Q+KG    L+ +  +     +   +    
Sbjct: 811  THALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQARQPGDRGEGETEPGTS 870

Query: 749  AEKPKVESQALATSLEESLNGNAVPEHQLTQEEEMEE--------------------GSL 788
             + P+  S      L    +  +VPE   T  E   E                    G +
Sbjct: 871  TKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRV 930

Query: 789  SWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMA 848
               V+  Y++A G  +    +F F+   V  +    +WLS W                  
Sbjct: 931  KATVHLAYLRAVGTPLCLYALFLFLCQQV-ASFCRGYWLSLW------------------ 971

Query: 849  DLGNIADNPQLSFYQLVYGLNALLLICVGVCSS-GIFTKVT------RKASTALHNKLFN 901
                 AD+P +   Q    L   +   +G   + G+F  +        +AS  L  +L  
Sbjct: 972  -----ADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLW 1026

Query: 902  KVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPY 961
             V R P+SFF+  PIG LLN F+ + + +D  +P      L+ +  ++ V L+V+V +P 
Sbjct: 1027 DVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATP- 1085

Query: 962  ILLMGAIIMVICFIYYMMFKKAIGV----FKRLENYSRSPLFSHILNSLQGLSSIHVYGK 1017
               +  + ++  F+ Y  F+    V     +RLE+ S S + SH+  + QG + +  +  
Sbjct: 1086 ---LATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRT 1142

Query: 1018 TEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFK 1077
               F++Q     D         L + RW+A  +E++ N +  A A       +       
Sbjct: 1143 QAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLV 1202

Query: 1078 VMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQ 1137
              +V+  LQ+  + Q   R   + E    +VER+  Y      EAP  +   +    WPQ
Sbjct: 1203 GFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDY-AWTPKEAPWRLPTCAAQPPWPQ 1261

Query: 1138 HGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197
             G+I F+D+ ++YR   P  + G++  I   E VGIVGRTG+GKSSL   L RL E   G
Sbjct: 1262 GGQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEG 1321

Query: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALE----- 1252
             I IDGV I  +GL  LRS++S+IPQDP+L  G++R NLD    H+D+ IW ALE     
Sbjct: 1322 GIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLK 1381

Query: 1253 --------------------------------RTFLTKA-IILIDEATASIDMETDTLIQ 1279
                                            R  L K  I+++DEATA++D  T+  +Q
Sbjct: 1382 ALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQ 1441

Query: 1280 RTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLF 1332
              +   F  CTVL+IAHR+ +V++C  +LVM  G+V E   P  L  + G  +
Sbjct: 1442 AMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFY 1494



 Score = 92.4 bits (228), Expect = 3e-18
 Identities = 57/216 (26%), Positives = 109/216 (50%), Gaps = 14/216 (6%)

Query: 530  INLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------SLAY 576
            ++  +  G  +G+ G TG+GKSSL S +L      EG + + G              ++ 
Sbjct: 1285 VSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISI 1344

Query: 577  VPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSG 636
            +PQ   +  G++R N+ +   +        L    L   +  LP     +  +RG +LS 
Sbjct: 1345 IPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSV 1404

Query: 637  GQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYL 696
            GQKQ + LARA+    QI +LD+  +AVD      + +  +       TV+L+ H+L+ +
Sbjct: 1405 GQKQLLCLARALLRKTQILILDEATAAVDPGTELQM-QAMLGSWFAQCTVLLIAHRLRSV 1463

Query: 697  EFCGQIILLENGKICENGTHSELMQKKGKYAQLIQK 732
              C ++++++ G++ E+G+ ++L+ +KG + +L Q+
Sbjct: 1464 MDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQE 1499



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 98/479 (20%), Positives = 193/479 (40%), Gaps = 46/479 (9%)

Query: 893  TALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVL 952
            +A+   ++ KV            +G ++N  + D+++L + +   +  +L L  +V+  +
Sbjct: 383  SAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFV 442

Query: 953  LIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRL--ENYSRSPLFSHILNSLQGLS 1010
             +  +L P  L   A+ + +  + + + KK     +    +  SR+ L S IL + +   
Sbjct: 443  YLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSK--- 499

Query: 1011 SIHVYGKTEDFISQFKRLTDAQNNYL----LLFLSSTRWMALRLEIMTNLVTLAVALFVA 1066
            +I  +G    F+ +   +   +   L    LLF  S     +  ++ T LV L V     
Sbjct: 500  TIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSL----VSFQVSTFLVALVVFAVHT 555

Query: 1067 FGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQF-TAVERILQYMKMCVSEAPLH 1125
                +   + K      VL + +  QA     + +  Q   + +R++ ++  C+ E    
Sbjct: 556  LVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFL--CLEEVDPG 613

Query: 1126 MEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLG 1185
            +  +S          I        +   +P  LH INLT+    ++ +VG  G+GKSSL 
Sbjct: 614  VVDSSSSGSAAGKDCITIHSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLL 673

Query: 1186 MALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQ-------DP-----VLLSGTIR 1233
             AL   +  + G + I+G  +  +  E      SV+         DP     VL +  ++
Sbjct: 674  SALLGELSKVEGFVSIEGA-VAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQ 732

Query: 1234 FNLDPFDRHTDQQIWD-------------ALERTFLTKAII-LIDEATASIDMETDTLIQ 1279
             ++D F       I +             +L R    KA + L+D+  A++D      + 
Sbjct: 733  PDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVF 792

Query: 1280 RTI---REAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAAL 1335
              +       QG T +++ H +  +   D I+V+ NG + E    + L ++ G+L   L
Sbjct: 793  NQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLL 851


>gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo
            sapiens]
          Length = 1581

 Score =  518 bits (1335), Expect = e-146
 Identities = 385/1415 (27%), Positives = 655/1415 (46%), Gaps = 172/1415 (12%)

Query: 55   RAAVPPWGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDE 114
            R   PP    D  +R + PF                L S  T  W+   +  + +  +D 
Sbjct: 202  REVKPPEDLQDLGVRFLQPF--------------VNLLSKGTYWWMNAFIKTAHKKPIDL 247

Query: 115  NTIPPLSVHDASDKNVQRLHRLWEEEVSR--RGIEKASVLLVMLR--FQRTRLIFDALLG 170
              I  L +   +  N QRL   ++ +V +  +G + A  +   L   F R RL+  +   
Sbjct: 248  RAIGKLPIAMRALTNYQRLCEAFDAQVRKDIQGTQGARAIWQALSHAFGR-RLVLSSTFR 306

Query: 171  ICFCIASVLGPILIIPKILEYSEEQ---------LGN--------VVHGVGLCFALFLSE 213
            I   +    GP+ I   +    +E          LG         + +   L   LFL+ 
Sbjct: 307  ILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFLGVYFVSSQEFLANAYVLAVLLFLAL 366

Query: 214  CVKSLSFSSSWIINQRTAIRFRAAVSSFAFEKLIQFK----SVIHITSGEAISFFTGDVN 269
             ++     +S+ +   T I  R A+ +  + K++       S+  +T+G+  +    D N
Sbjct: 367  LLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTN 426

Query: 270  YLFEGVCYGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQH 329
             L       P +      +++  I  Y+I+G +A I     +L+ P+  F+     +AQ 
Sbjct: 427  QLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQR 486

Query: 330  HTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSIT 389
             T E S++R++ T+E+L  IKL+K+Y WE  F   +E  RRKE   L    +  S++   
Sbjct: 487  STLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYTSISIFM 546

Query: 390  LFIIPTVATAVWVLIHTSL--KLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSA 447
               IP  A  +  + H S   +   + S+AF+ L+  ++L   +F +   V+    +  +
Sbjct: 547  NTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVS 606

Query: 448  VMRFKKFFL-----QESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALELERNGH 502
            V +  +F       +E    +  T Q P+           +Q     +VN       +  
Sbjct: 607  VQKLSEFLSSAEIREEQCAPHEPTPQGPAS---------KYQAVPLRVVNRKRPARED-- 655

Query: 503  ASEGMTRPRDALGPEEEGNS-------LG----------PELHKINLVVSKGMMLGVCGN 545
               G+T P  +L P  +G++       +G          P L  I + + +G +  + G 
Sbjct: 656  -CRGLTGPLQSLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQ 714

Query: 546  TGSGKSSLLSAILEEMHLLEGSV--------------------------GVQGSLAYVPQ 579
             G GKSSLL A L EM  + G+V                            +G +AY  Q
Sbjct: 715  VGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQ 774

Query: 580  QAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQK 639
            + W+++  + ENI+    ++K RY  V+  CSL  D+++LP GD T+IGERG+NLSGGQ+
Sbjct: 775  KPWLLNATVEENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQR 834

Query: 640  QRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRG--KTVVLVTHQLQYLE 697
            QRIS+ARA+Y    +  LDDP SA+D H+  H+ +  I + LR   +TVVLVTH+LQYL 
Sbjct: 835  QRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLP 894

Query: 698  FCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTA---KIAEKPKV 754
                II +++G I   GT  +  + + +  +  + +      ++ ++T    K  E P+ 
Sbjct: 895  HADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVTERKATEPPQG 954

Query: 755  ESQALATSLEESLNGNAVPEHQLTQEEE--------MEEGSLSWRVYHHYIQAAGGYMVS 806
             S+A++ S +  L      E +  + EE         +   + WR    Y+ +AG  ++S
Sbjct: 955  LSRAMS-SRDGLLQDEEEEEEEAAESEEDDNLSSMLHQRAEIPWRACAKYLSSAGILLLS 1013

Query: 807  CIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVY 866
             ++F  ++  + L    +W L+ W +       +           N + + + +  Q VY
Sbjct: 1014 LLVFSQLLKHMVLVAIDYW-LAKWTDSALTLTPAAR---------NCSLSQECTLDQTVY 1063

Query: 867  GLNALLLICVGVCSSGIFTKVT-----RKASTALHNKLFNKVFRCPMSFFDTIPIGRLLN 921
             +   +L  +G+    + T VT      K +  LH  L N++   PM FF+T P+G +LN
Sbjct: 1064 AMVFTVLCSLGIVLC-LVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILN 1122

Query: 922  CFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFK 981
             F+ D   +DQ +P   E     +L+ ++ L ++S ++P  L+    + ++C+     F+
Sbjct: 1123 RFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVISYVTPVFLVALLPLAIVCYFIQKYFR 1182

Query: 982  KAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLS 1041
             A    ++L++ ++ PL SH   +++GL++I  +     F  +    TD+ N   L   +
Sbjct: 1183 VASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTA 1242

Query: 1042 STRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMAVNIV--LQLASSFQATARIGL 1099
            + RW+ +R+E +   V L  A+           S  ++ + +   L +++      R   
Sbjct: 1243 ANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLA 1302

Query: 1100 ETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLH 1159
            + E Q  AV+RI   +K         +  +  P+ WP  G+I  Q+  ++Y  +   VL 
Sbjct: 1303 DMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLK 1362

Query: 1160 GINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLS 1219
             +N  I   + +GI GRTGSGKSS  +A FR+V+   G I+IDG+DI  + L  LRS+LS
Sbjct: 1363 HVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLS 1422

Query: 1220 VIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALE--------------------------- 1252
            +I QDPVL SGTIRFNLDP  + +D  +W+ALE                           
Sbjct: 1423 IILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFS 1482

Query: 1253 ----------RTFLTK-AIILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTV 1301
                      R F+ K +I ++DEATASIDM T+ ++Q+ +  AF   TV+ IAHRV T+
Sbjct: 1483 QGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTI 1542

Query: 1302 LNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALM 1336
            L+ D ++V+  G ++EFD+PE L  +  S+FA+ +
Sbjct: 1543 LSADLVIVLKRGAILEFDKPEKLLSRKDSVFASFV 1577


>gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 1312

 Score =  518 bits (1335), Expect = e-146
 Identities = 399/1366 (29%), Positives = 628/1366 (45%), Gaps = 181/1366 (13%)

Query: 79   RFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWE 138
            ++  P P   A   S  T  W++ L+ +  R  L    +  L   ++S++ V RL + W 
Sbjct: 7    KYTNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWM 66

Query: 139  EEVS------------RRGIE--KASVLLVMLRFQRT--RLIFDALLGICFCIASVLGPI 182
               S            R+G    KA      LR + +  R +  A+  + F    +LG +
Sbjct: 67   RNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQV-FHSTFLLGTL 125

Query: 183  LII---------PKILEYSEEQLGN----VVHGVGLCFALFLSECVKSLSFSSSWIINQR 229
             +I         PK+L    E +G+       G  L   +FLS C+++L    +    + 
Sbjct: 126  SLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKV 185

Query: 230  TAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPLVLITCAS 287
              +R R+A++   + K++   S     S  G+ ++  + DV  L E V Y   + +    
Sbjct: 186  LQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVW 245

Query: 288  LVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEV---SDQRIRVTSE 344
            +V+C +  + ++G +A  AI  +L + PL  F+++   K  HH  E     D R R+TS 
Sbjct: 246  IVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISK---KRNHHQEEQMRQKDSRARLTSS 302

Query: 345  VLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLI 404
            +L   K IK + WE  F   +  +R +E   L   GL+ S++ ++  +   +   V   +
Sbjct: 303  ILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAV 362

Query: 405  HTSL-KLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFF-LQESPVF 462
            HT + +  + A  AF  L  LN+L  +  F+P ++  L  ++ +  R   F  L+E    
Sbjct: 363  HTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDPG 422

Query: 463  YVQTLQDPSKA----LVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEE 518
             V +    S A    +  + AT +W Q  P                              
Sbjct: 423  AVDSSSSGSAAGKDCITIQSATFAWSQESP------------------------------ 452

Query: 519  EGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVP 578
                  P LH+INL V +G +L V G  G+GKSSLLSA+L E+  +EG V ++G++AYVP
Sbjct: 453  ------PCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVP 506

Query: 579  QQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQ 638
            Q+AW+ + ++ EN+  G   D     +VL  C+L  D++  P G  T IGE+G+NLSGGQ
Sbjct: 507  QEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQ 566

Query: 639  KQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKK--TLRGKTVVLVTHQLQYL 696
            KQR+SLARAVY    +YLLDDPL+A+DAHVG+H+F + I     L+G T +LVTH L  L
Sbjct: 567  KQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHIL 626

Query: 697  EFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEA-TSDMLQDTAKIAEKPKVE 755
                 II+L NG I E G++ EL+Q+KG    L+ +  +     +   +     + P+  
Sbjct: 627  PQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQARQPGDRGEGETEPGTSTKDPRGT 686

Query: 756  SQALATSLEESLNGNAVPEHQLTQEEEMEE--------------------GSLSWRVYHH 795
            S      L    +  +VPE   T  E   E                    G +   V+  
Sbjct: 687  SAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKATVHLA 746

Query: 796  YIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIAD 855
            Y++A G  +    +F F+   V  +    +WLS W                       AD
Sbjct: 747  YLRAVGTPLCLYALFLFLCQQV-ASFCRGYWLSLW-----------------------AD 782

Query: 856  NPQLSFYQLVYGLNALLLICVGVCSS-GIFTKVT------RKASTALHNKLFNKVFRCPM 908
            +P +   Q    L   +   +G   + G+F  +        +AS  L  +L   V R P+
Sbjct: 783  DPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPI 842

Query: 909  SFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAI 968
            SFF+  PIG LLN F+ + + +D  +P      L+ +  ++ V L+V+V +P    +  +
Sbjct: 843  SFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATP----LATV 898

Query: 969  IMVICFIYYMMFKKAIGV----FKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQ 1024
             ++  F+ Y  F+    V     +RLE+ S S + SH+  + QG + +  +     F++Q
Sbjct: 899  AILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQ 958

Query: 1025 FKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMAVNIV 1084
                 D         L + RW+A  +E++ N +  A A       +         +V+  
Sbjct: 959  NNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAA 1018

Query: 1085 LQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQ 1144
            LQ+  + Q   R   + E    +VER+  Y      EAP  +   +    WPQ G+I FQ
Sbjct: 1019 LQVTQTLQWVVRNWTDLENSIVSVERMQDY-AWTPKEAPWRLPTCAAQPPWPQGGQIEFQ 1077

Query: 1145 DYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGV 1204
            D+ ++YR   P  + G++  I   E VGIVGRTG+GKSSL   L RL E   G I IDGV
Sbjct: 1078 DFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGV 1137

Query: 1205 DICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALE------------ 1252
             I  +GL  LRS++S+IPQDP+L  G++R NLD    H+D+ IW ALE            
Sbjct: 1138 PIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLP 1197

Query: 1253 -------------------------RTFLTKA-IILIDEATASIDMETDTLIQRTIREAF 1286
                                     R  L K  I+++DEATA++D  T+  +Q  +   F
Sbjct: 1198 GQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWF 1257

Query: 1287 QGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLF 1332
              CTVL+IAHR+ +V++C  +LVM  G+V E   P  L  + G  +
Sbjct: 1258 AQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFY 1303



 Score = 92.4 bits (228), Expect = 3e-18
 Identities = 57/216 (26%), Positives = 109/216 (50%), Gaps = 14/216 (6%)

Query: 530  INLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------SLAY 576
            ++  +  G  +G+ G TG+GKSSL S +L      EG + + G              ++ 
Sbjct: 1094 VSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISI 1153

Query: 577  VPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSG 636
            +PQ   +  G++R N+ +   +        L    L   +  LP     +  +RG +LS 
Sbjct: 1154 IPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSV 1213

Query: 637  GQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYL 696
            GQKQ + LARA+    QI +LD+  +AVD      + +  +       TV+L+ H+L+ +
Sbjct: 1214 GQKQLLCLARALLRKTQILILDEATAAVDPGTELQM-QAMLGSWFAQCTVLLIAHRLRSV 1272

Query: 697  EFCGQIILLENGKICENGTHSELMQKKGKYAQLIQK 732
              C ++++++ G++ E+G+ ++L+ +KG + +L Q+
Sbjct: 1273 MDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQE 1308



 Score = 64.3 bits (155), Expect = 7e-10
 Identities = 99/479 (20%), Positives = 193/479 (40%), Gaps = 46/479 (9%)

Query: 893  TALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVL 952
            +A+   ++ KV            +G ++N  + D+++L + +   +  +L L  +V+  +
Sbjct: 192  SAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFV 251

Query: 953  LIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRL--ENYSRSPLFSHILNSLQGLS 1010
             +  +L P  L   A+ + +  + + + KK     +    +  SR+ L S IL + +   
Sbjct: 252  YLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSK--- 308

Query: 1011 SIHVYGKTEDFISQFKRLTDAQNNYL----LLFLSSTRWMALRLEIMTNLVTLAVALFVA 1066
            +I  +G    F+ +   +   +   L    LLF  S     +  ++ T LV L V     
Sbjct: 309  TIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSL----VSFQVSTFLVALVVFAVHT 364

Query: 1067 FGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQF-TAVERILQYMKMCVSEAPLH 1125
                +   + K      VL + +  QA     + +  Q   + +R++ ++  C+ E    
Sbjct: 365  LVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFL--CLEEVDPG 422

Query: 1126 MEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLG 1185
               +S          I  Q     +   +P  LH INLT+    ++ +VG  G+GKSSL 
Sbjct: 423  AVDSSSSGSAAGKDCITIQSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLL 482

Query: 1186 MALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQ-------DP-----VLLSGTIR 1233
             AL   +  + G + I+G  +  +  E      SV+         DP     VL +  ++
Sbjct: 483  SALLGELSKVEGFVSIEGA-VAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQ 541

Query: 1234 FNLDPFDRHTDQQIWD-------------ALERTFLTKAII-LIDEATASIDMETDTLIQ 1279
             ++D F       I +             +L R    KA + L+D+  A++D      + 
Sbjct: 542  PDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVF 601

Query: 1280 RTI---REAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAAL 1335
              +       QG T +++ H +  +   D I+V+ NG + E    + L ++ G+L   L
Sbjct: 602  NQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLL 660


>gi|110832837 ATP-binding cassette, sub-family C, member 9 isoform
            SUR2B [Homo sapiens]
          Length = 1549

 Score =  510 bits (1314), Expect = e-144
 Identities = 391/1396 (28%), Positives = 644/1396 (46%), Gaps = 172/1396 (12%)

Query: 59   PPWGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIP 118
            PP    D  +R + PF                L S  T  W+  L+I + +  +D   I 
Sbjct: 204  PPEDLQDLGVRFLQPF--------------VNLLSKATYWWMNTLIISAHKKPIDLKAIG 249

Query: 119  PLSVHDASDKNVQRLHRLWEEE---VSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCI 175
             L +   +  N   L   +EE+   V+       S+ L M R     ++  +       +
Sbjct: 250  KLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADL 309

Query: 176  ASVLGPILIIPKILEYSEEQLG-NVVHGVG--------------LCFALFLSECVKSLSF 220
                GP+ I   +   +E Q G N   G+               L   LFL+  ++    
Sbjct: 310  LGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQRTFL 369

Query: 221  SSSWIINQRTAIRFRAAVSSFAFEKLIQFK----SVIHITSGEAISFFTGDVNYLFEGVC 276
             +S+ +   T I  R A+ +  + K+++      S+  +T G+  +    + N L   + 
Sbjct: 370  QASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLF 429

Query: 277  YGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSD 336
              P +      +++  I  Y ++G +A +     +L+ P+  F+     +AQ  T + S 
Sbjct: 430  LCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYST 489

Query: 337  QRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTV 396
            +R++ T+E+L  IKL+K+Y WE  F K +E+ R KE   L+   L  SL+      IP  
Sbjct: 490  ERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIA 549

Query: 397  ATAVWVLIHTSLK-LKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFF 455
            A     + H       L  + AF+ L+  ++L   +F +   V+    +  +V +  +F 
Sbjct: 550  AVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFL 609

Query: 456  LQESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVN----GALELERNGHASEGMTRPR 511
            L +       + +    +L FE          P  +N    G   L+    ++  + RP 
Sbjct: 610  LSDE--IGDDSWRTGESSLPFESCK-KHTGVQPKTINRKQPGRYHLDSYEQSTRRL-RPA 665

Query: 512  DAL--------GPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHL 563
            +          G    G+ L   L  I++ +  G +  + G  G GKSSLL AIL EM  
Sbjct: 666  ETEDIAIKVTNGYFSWGSGLAT-LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQT 724

Query: 564  LEGSVGVQG-----------------SLAYVPQQAWIVSGNIRENILMGGAYDKARYLQV 606
            LEG V                     S+AY  Q+ W+++  + ENI  G  ++K RY  V
Sbjct: 725  LEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAV 784

Query: 607  LHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDA 666
               CSL  D++LLPFGD TEIGERG+NLSGGQ+QRI +ARA+Y +  I  LDDP SA+D 
Sbjct: 785  TDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDI 844

Query: 667  HVGKHIFEECIKKTLRG--KTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKG 724
            H+  H+ +E I K L+   +T+VLVTH+LQYL     II +++G +   GT  ++  K  
Sbjct: 845  HLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDV 904

Query: 725  K----YAQLIQKMHKEATSDMLQDTAKIAEKP---KVESQALATSLEESLNGNAVPEHQL 777
            +    +  L+ +  +E   DM  D   +  K     + S+     +E+        E + 
Sbjct: 905  ELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMED--------EDEE 956

Query: 778  TQEEEMEEGSLS----------WRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWL 827
             +EEE E+ ++S          W+    Y+  +GG+ +  ++ F  +L   + +   +WL
Sbjct: 957  EEEEEDEDDNMSTVMRLRTKMPWKTCWRYL-TSGGFFLLILMIFSKLLKHSVIVAIDYWL 1015

Query: 828  SYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIF--- 884
            + W  + S  N+ +                  ++Y  V G + L       C +GIF   
Sbjct: 1016 ATWTSEYSINNTGKADQ---------------TYY--VAGFSIL-------CGAGIFLCL 1051

Query: 885  -TKVTRK-----ASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFS 938
             T +T +     A+  LH+ L NK+   P+ FFDT P+G +LN F+ D   +DQ +P   
Sbjct: 1052 VTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTL 1111

Query: 939  EQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPL 998
            E     +L+ ++ + ++S  +P  L+    + V  +     F+ A    + L++ ++ PL
Sbjct: 1112 ESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPL 1171

Query: 999  FSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVT 1058
              H   + +GL++I  +     F  +   LTD  N   L   ++ RW+ +R + +   + 
Sbjct: 1172 LCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIV 1231

Query: 1059 LAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMC 1118
            L  ++    G S++      + +   L + +      R   + E Q  AV+++  ++ M 
Sbjct: 1232 LTASIASISGSSNS--GLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTME 1289

Query: 1119 VSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTG 1178
                   M+ +  P+ WPQ GEI   D  ++Y +N   VL  +   I+  + VGI GRTG
Sbjct: 1290 SENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTG 1349

Query: 1179 SGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDP 1238
            SGKSSL +A FR+V+   G+I+IDG+DI  + L  LRS+LS+I QDP+L SG+IRFNLDP
Sbjct: 1350 SGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDP 1409

Query: 1239 FDRHTDQQIWDALE-------------------------------------RTFLTKAII 1261
              + TD ++W+ALE                                     R F+ K+ I
Sbjct: 1410 ECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSI 1469

Query: 1262 LI-DEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDR 1320
            LI DEATASIDM T+ ++Q+ +  AF   TV+ IAHRV T+L  D ++VM  G ++E+D 
Sbjct: 1470 LIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDT 1529

Query: 1321 PEVLRKKPGSLFAALM 1336
            PE L  +   +FA+ +
Sbjct: 1530 PESLLAQENGVFASFV 1545



 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 61/225 (27%), Positives = 105/225 (46%), Gaps = 15/225 (6%)

Query: 521  NSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------- 572
            N+L P L  +   +  G  +G+CG TGSGKSSL  A    + + +G + + G        
Sbjct: 1323 NNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPL 1382

Query: 573  -----SLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEI 627
                  L+ + Q   + SG+IR N+         R  + L    L   ++ LP G    +
Sbjct: 1383 HTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVV 1442

Query: 628  GERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVV 687
             E G N S GQ+Q   LARA      I ++D+  +++D    ++I ++ +      +TVV
Sbjct: 1443 TEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDM-ATENILQKVVMTAFADRTVV 1501

Query: 688  LVTHQLQYLEFCGQIILLENGKICENGT-HSELMQKKGKYAQLIQ 731
             + H++  +     +I+++ G I E  T  S L Q+ G +A  ++
Sbjct: 1502 TIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQENGVFASFVR 1546


>gi|110832839 ATP-binding cassette, sub-family C, member 9 isoform
            SUR2A-delta-14 [Homo sapiens]
          Length = 1513

 Score =  502 bits (1292), Expect = e-141
 Identities = 390/1387 (28%), Positives = 639/1387 (46%), Gaps = 186/1387 (13%)

Query: 59   PPWGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIP 118
            PP    D  +R + PF                L S  T  W+  L+I + +  +D   I 
Sbjct: 204  PPEDLQDLGVRFLQPF--------------VNLLSKATYWWMNTLIISAHKKPIDLKAIG 249

Query: 119  PLSVHDASDKNVQRLHRLWEEE---VSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCI 175
             L +   +  N   L   +EE+   V+       S+ L M R     ++  +       +
Sbjct: 250  KLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADL 309

Query: 176  ASVLGPILIIPKILEYSEEQLG-NVVHGVG--------------LCFALFLSECVKSLSF 220
                GP+ I   +   +E Q G N   G+               L   LFL+  ++    
Sbjct: 310  LGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQRTFL 369

Query: 221  SSSWIINQRTAIRFRAAVSSFAFEKLIQFK----SVIHITSGEAISFFTGDVNYLFEGVC 276
             +S+ +   T I  R A+ +  + K+++      S+  +T G+  +    + N L   + 
Sbjct: 370  QASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLF 429

Query: 277  YGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSD 336
              P +      +++  I  Y ++G +A +     +L+ P+  F+     +AQ  T + S 
Sbjct: 430  LCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYST 489

Query: 337  QRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTV 396
            +R++ T+E+L  IKL+K+Y WE  F K +E+ R KE   L+   L  SL+      IP  
Sbjct: 490  ERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIA 549

Query: 397  ATAVWVLIHTSLK-LKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFF 455
            A     + H       L  + AF+ L+  ++L   +F +   V+    +  +V +  +F 
Sbjct: 550  AVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFL 609

Query: 456  LQESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRDALG 515
            L +       + +    +L FE       +   G+V        NG+ S G         
Sbjct: 610  LSDE--IGDDSWRTGESSLPFESC-----KKHTGVVT-------NGYFSWG--------- 646

Query: 516  PEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG--- 572
                  S    L  I++ +  G +  + G  G GKSSLL AIL EM  LEG V       
Sbjct: 647  ------SGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNE 700

Query: 573  --------------SLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLEL 618
                          S+AY  Q+ W+++  + ENI  G  ++K RY  V   CSL  D++L
Sbjct: 701  SEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDL 760

Query: 619  LPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIK 678
            LPFGD TEIGERG+NLSGGQ+QRI +ARA+Y +  I  LDDP SA+D H+  H+ +E I 
Sbjct: 761  LPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGIL 820

Query: 679  KTLRG--KTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGK----YAQLIQK 732
            K L+   +T+VLVTH+LQYL     II +++G +   GT  ++  K  +    +  L+ +
Sbjct: 821  KFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNR 880

Query: 733  MHKEATSDMLQDTAKIAEKP---KVESQALATSLEESLNGNAVPEHQLTQEEEMEEGSLS 789
              +E   DM  D   +  K     + S+     +E+        E +  +EEE E+ ++S
Sbjct: 881  QDQELEKDMEADQTTLERKTLRRAMYSREAKAQMED--------EDEEEEEEEDEDDNMS 932

Query: 790  ----------WRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNS 839
                      W+    Y+  +GG+ +  ++ F  +L   + +   +WL+ W  + S  N+
Sbjct: 933  TVMRLRTKMPWKTCWRYL-TSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINNT 991

Query: 840  SRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIF----TKVTRK----- 890
             +                  ++Y  V G + L       C +GIF    T +T +     
Sbjct: 992  GKADQ---------------TYY--VAGFSIL-------CGAGIFLCLVTSLTVEWMGLT 1027

Query: 891  ASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIA 950
            A+  LH+ L NK+   P+ FFDT P+G +LN F+ D   +DQ +P   E     +L+ ++
Sbjct: 1028 AAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLS 1087

Query: 951  VLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLS 1010
             + ++S  +P  L+    + V  +     F+ A    + L++ ++ PL  H   + +GL+
Sbjct: 1088 AIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLT 1147

Query: 1011 SIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGIS 1070
            +I  +     F  +   LTD  N   L   ++ RW+ +R + +   + L  ++    G S
Sbjct: 1148 TIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSS 1207

Query: 1071 STPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTS 1130
            ++      + +   L + +      R   + E Q  AV+++  ++ M        M+ + 
Sbjct: 1208 NS--GLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQ 1265

Query: 1131 CPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFR 1190
             P+ WPQ GEI   D  ++Y +N   VL  +   I+  + VGI GRTGSGKSSL +A FR
Sbjct: 1266 VPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFR 1325

Query: 1191 LVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDA 1250
            +V+   G+I+IDG+DI  + L  LRS+LS+I QDP+L SG+IRFNLDP  + TD ++W+A
Sbjct: 1326 MVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEA 1385

Query: 1251 LE-------------------------------------RTFLTKAIILI-DEATASIDM 1272
            LE                                     R F+ K+ ILI DEATASIDM
Sbjct: 1386 LEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDM 1445

Query: 1273 ETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDR-PEVLRKKPGSL 1331
             T+ ++Q+ +  AF   TV+ IAHRV+++++   +LV   G +VE D  P +L  K G L
Sbjct: 1446 ATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNG-L 1504

Query: 1332 FAALMAT 1338
            F+ L+ T
Sbjct: 1505 FSTLVMT 1511


>gi|110832835 ATP-binding cassette, sub-family C, member 9 isoform
            SUR2A [Homo sapiens]
          Length = 1549

 Score =  500 bits (1288), Expect = e-141
 Identities = 392/1399 (28%), Positives = 645/1399 (46%), Gaps = 174/1399 (12%)

Query: 59   PPWGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIP 118
            PP    D  +R + PF                L S  T  W+  L+I + +  +D   I 
Sbjct: 204  PPEDLQDLGVRFLQPF--------------VNLLSKATYWWMNTLIISAHKKPIDLKAIG 249

Query: 119  PLSVHDASDKNVQRLHRLWEEE---VSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCI 175
             L +   +  N   L   +EE+   V+       S+ L M R     ++  +       +
Sbjct: 250  KLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADL 309

Query: 176  ASVLGPILIIPKILEYSEEQLG-NVVHGVG--------------LCFALFLSECVKSLSF 220
                GP+ I   +   +E Q G N   G+               L   LFL+  ++    
Sbjct: 310  LGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQRTFL 369

Query: 221  SSSWIINQRTAIRFRAAVSSFAFEKLIQFK----SVIHITSGEAISFFTGDVNYLFEGVC 276
             +S+ +   T I  R A+ +  + K+++      S+  +T G+  +    + N L   + 
Sbjct: 370  QASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLF 429

Query: 277  YGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSD 336
              P +      +++  I  Y ++G +A +     +L+ P+  F+     +AQ  T + S 
Sbjct: 430  LCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYST 489

Query: 337  QRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTV 396
            +R++ T+E+L  IKL+K+Y WE  F K +E+ R KE   L+   L  SL+      IP  
Sbjct: 490  ERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIA 549

Query: 397  ATAVWVLIHTSLK-LKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFF 455
            A     + H       L  + AF+ L+  ++L   +F +   V+    +  +V +  +F 
Sbjct: 550  AVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFL 609

Query: 456  LQESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVN----GALELERNGHASEGMTRPR 511
            L +       + +    +L FE          P  +N    G   L+    ++  + RP 
Sbjct: 610  LSDE--IGDDSWRTGESSLPFESCK-KHTGVQPKTINRKQPGRYHLDSYEQSTRRL-RPA 665

Query: 512  DAL--------GPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHL 563
            +          G    G+ L   L  I++ +  G +  + G  G GKSSLL AIL EM  
Sbjct: 666  ETEDIAIKVTNGYFSWGSGLAT-LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQT 724

Query: 564  LEGSVGVQG-----------------SLAYVPQQAWIVSGNIRENILMGGAYDKARYLQV 606
            LEG V                     S+AY  Q+ W+++  + ENI  G  ++K RY  V
Sbjct: 725  LEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAV 784

Query: 607  LHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDA 666
               CSL  D++LLPFGD TEIGERG+NLSGGQ+QRI +ARA+Y +  I  LDDP SA+D 
Sbjct: 785  TDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDI 844

Query: 667  HVGKHIFEECIKKTLRG--KTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKG 724
            H+  H+ +E I K L+   +T+VLVTH+LQYL     II +++G +   GT  ++  K  
Sbjct: 845  HLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDV 904

Query: 725  K----YAQLIQKMHKEATSDMLQDTAKIAEKP---KVESQALATSLEESLNGNAVPEHQL 777
            +    +  L+ +  +E   DM  D   +  K     + S+     +E+        E + 
Sbjct: 905  ELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMED--------EDEE 956

Query: 778  TQEEEMEEGSLS----------WRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWL 827
             +EEE E+ ++S          W+    Y+  +GG+ +  ++ F  +L   + +   +WL
Sbjct: 957  EEEEEDEDDNMSTVMRLRTKMPWKTCWRYL-TSGGFFLLILMIFSKLLKHSVIVAIDYWL 1015

Query: 828  SYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIF--- 884
            + W  + S  N+ +                  ++Y  V G + L       C +GIF   
Sbjct: 1016 ATWTSEYSINNTGKADQ---------------TYY--VAGFSIL-------CGAGIFLCL 1051

Query: 885  -TKVTRK-----ASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFS 938
             T +T +     A+  LH+ L NK+   P+ FFDT P+G +LN F+ D   +DQ +P   
Sbjct: 1052 VTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTL 1111

Query: 939  EQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPL 998
            E     +L+ ++ + ++S  +P  L+    + V  +     F+ A    + L++ ++ PL
Sbjct: 1112 ESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPL 1171

Query: 999  FSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVT 1058
              H   + +GL++I  +     F  +   LTD  N   L   ++ RW+ +R + +   + 
Sbjct: 1172 LCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIV 1231

Query: 1059 LAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMC 1118
            L  ++    G S++      + +   L + +      R   + E Q  AV+++  ++ M 
Sbjct: 1232 LTASIASISGSSNS--GLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTME 1289

Query: 1119 VSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTG 1178
                   M+ +  P+ WPQ GEI   D  ++Y +N   VL  +   I+  + VGI GRTG
Sbjct: 1290 SENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTG 1349

Query: 1179 SGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDP 1238
            SGKSSL +A FR+V+   G+I+IDG+DI  + L  LRS+LS+I QDP+L SG+IRFNLDP
Sbjct: 1350 SGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDP 1409

Query: 1239 FDRHTDQQIWDALE-------------------------------------RTFLTKAII 1261
              + TD ++W+ALE                                     R F+ K+ I
Sbjct: 1410 ECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSI 1469

Query: 1262 LI-DEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDR 1320
            LI DEATASIDM T+ ++Q+ +  AF   TV+ IAHRV+++++   +LV   G +VE D 
Sbjct: 1470 LIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDT 1529

Query: 1321 -PEVLRKKPGSLFAALMAT 1338
             P +L  K G LF+ L+ T
Sbjct: 1530 VPNLLAHKNG-LFSTLVMT 1547


>gi|134142345 ATP-binding cassette, sub-family C, member 1 isoform 3
            [Homo sapiens]
          Length = 1475

 Score =  470 bits (1209), Expect = e-132
 Identities = 357/1374 (25%), Positives = 617/1374 (44%), Gaps = 232/1374 (16%)

Query: 81   PAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEE 140
            P P P  +A   S +T  W+T L+++  R  L+ + +  L+  D S++ V  L + W++E
Sbjct: 205  PNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKE 264

Query: 141  VSRRGIEKASVL-----------------------LVMLRFQR--TRLIFDAL---LGIC 172
             ++   +   V+                       L++   Q+     +F  L    G  
Sbjct: 265  CAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPY 324

Query: 173  FCIASVLGPI---------LIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSS 223
            F ++     I          I+  ++++  +       G      LF++ C+++L     
Sbjct: 325  FLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQY 384

Query: 224  WIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPLV 281
            + I   + +R + AV    + K +   +    +S  GE ++  + D     +   Y  ++
Sbjct: 385  FHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMI 444

Query: 282  LITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRV 341
                  +++     +  +G +    +   +L+ P+   M       Q    +  D RI++
Sbjct: 445  WSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKL 504

Query: 342  TSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVW 401
             +E+L  IK++K+Y WE  F   +  +R++E K+L+K   + ++ + T    P +     
Sbjct: 505  MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCT 564

Query: 402  VLIHTSLKLK--LTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQES 459
              ++ ++     L A  AF  LA  N+LR  +  +P+ +  +  +  ++ R + F   E 
Sbjct: 565  FAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEE 624

Query: 460  ---PVFYVQTLQDP--SKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRDAL 514
                    + ++D   + ++    AT +W ++ P  +NG                     
Sbjct: 625  LEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNG--------------------- 663

Query: 515  GPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSL 574
                           I   + +G ++ V G  G GKSSLLSA+L EM  +EG V ++GS+
Sbjct: 664  ---------------ITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSV 708

Query: 575  AYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNL 634
            AYVPQQAWI + ++RENIL G   ++  Y  V+  C+L  DLE+               L
Sbjct: 709  AYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEI---------------L 753

Query: 635  SGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQ 694
              G +  I                                         KT +LVTH + 
Sbjct: 754  PSGDRTEIG---------------------------------------EKTRILVTHSMS 774

Query: 695  YLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAKIA----- 749
            YL     II++  GKI E G++ EL+ + G +A+ ++     A+++  QD  +       
Sbjct: 775  YLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTY---ASTEQEQDAEENGVTGVS 831

Query: 750  ----EKPKVESQALAT-----------SLEESLNGNAVPEHQLTQE-------------- 780
                E  ++E+  L T           S   S +G+    H  T E              
Sbjct: 832  GPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKL 891

Query: 781  ---EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGT 837
               ++ + G +   VY  Y++A G ++    IF F+   V   + S +WLS W +     
Sbjct: 892  MEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVS-ALASNYWLSLWTDDPIVN 950

Query: 838  NSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHN 897
             +   +   ++  G +  +  ++    V+G +      + V   GI       AS  LH 
Sbjct: 951  GTQEHTKVRLSVYGALGISQGIA----VFGYS------MAVSIGGIL------ASRCLHV 994

Query: 898  KLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSV 957
             L + + R PMSFF+  P G L+N F+ +L+ +D ++P   + F+     VI   +++ +
Sbjct: 995  DLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILL 1054

Query: 958  LSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGK 1017
             +P   ++   + +I F     +  +    KRLE+ SRSP++SH   +L G+S I  + +
Sbjct: 1055 ATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEE 1114

Query: 1018 TEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFK 1077
             E FI Q     D         + + RW+A+RLE + N + L  ALF      S      
Sbjct: 1115 QERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLV 1174

Query: 1078 VMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQ 1137
             ++V+  LQ+ +      R+  E E    AVER+ +Y +    EAP  ++ T+ P  WPQ
Sbjct: 1175 GLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET-EKEAPWQIQETAPPSSWPQ 1233

Query: 1138 HGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197
             G + F++Y ++YR++   VL  IN+TI G E VGIVGRTG+GKSSL + LFR+ E   G
Sbjct: 1234 VGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEG 1293

Query: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALE----- 1252
             I+IDG++I  IGL DLR K+++IPQDPVL SG++R NLDPF +++D+++W +LE     
Sbjct: 1294 EIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLK 1353

Query: 1253 --------------------------------RTFLTKA-IILIDEATASIDMETDTLIQ 1279
                                            R  L K  I+++DEATA++D+ETD LIQ
Sbjct: 1354 DFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQ 1413

Query: 1280 RTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFA 1333
             TIR  F+ CTVL IAHR+ T+++   ++V+  G++ E+  P  L ++ G  ++
Sbjct: 1414 STIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYS 1467



 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 65/224 (29%), Positives = 105/224 (46%), Gaps = 18/224 (8%)

Query: 527  LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
            L  IN+ ++ G  +G+ G TG+GKSSL   +       EG + + G              
Sbjct: 1254 LRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFK 1313

Query: 574  LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLN 633
            +  +PQ   + SG++R N+     Y        L    L   +  LP     E  E G N
Sbjct: 1314 ITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGEN 1373

Query: 634  LSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQL 693
            LS GQ+Q + LARA+    +I +LD+  +AVD      + +  I+      TV+ + H+L
Sbjct: 1374 LSVGQRQLVCLARALLRKTKILVLDEATAAVDLET-DDLIQSTIRTQFEDCTVLTIAHRL 1432

Query: 694  QYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEA 737
              +    ++I+L+ G+I E G  S+L+Q++G    L   M K+A
Sbjct: 1433 NTIMDYTRVIVLDKGEIQEYGAPSDLLQQRG----LFYSMAKDA 1472



 Score = 48.1 bits (113), Expect = 6e-05
 Identities = 92/474 (19%), Positives = 188/474 (39%), Gaps = 72/474 (15%)

Query: 890  KASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVI 949
            +  TA+   ++ K      S   +  +G ++N  + D ++   L    +  +     +++
Sbjct: 394  RIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVIL 453

Query: 950  AVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKA----IGVFKRLENYSRSPLFSHILNS 1005
            A+ L+   L P +L   A+++++  +  +M  K     +   K  +N  R  L + ILN 
Sbjct: 454  ALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDN--RIKLMNEILNG 511

Query: 1006 LQGLS--SIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWM-----------ALRLEI 1052
            ++ L   +  +  K +    + + L   + +  L  + +  W+           A+ + I
Sbjct: 512  IKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTI 571

Query: 1053 MTNLVTLAVALFVA---FGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVE 1109
              N +  A   FV+   F I   P +   M ++ ++Q + S +         E +  ++E
Sbjct: 572  DENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIE 631

Query: 1110 RILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHE 1169
            R            P+   G +          I  ++    +  + P  L+GI  +I    
Sbjct: 632  R-----------RPVKDGGGT--------NSITVRNATFTWARSDPPTLNGITFSIPEGA 672

Query: 1170 VVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLS 1229
            +V +VG+ G GKSSL  AL   ++ + G + I G              ++ +PQ   + +
Sbjct: 673  LVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG-------------SVAYVPQQAWIQN 719

Query: 1230 GTIRFNLDPFDRHTDQQIWDALERTFLTKAIILID-EATASIDMETDTLIQRTIREAFQG 1288
             ++R N+         Q+ +   R+ +    +L D E   S D           R     
Sbjct: 720  DSLRENI-----LFGCQLEEPYYRSVIQACALLPDLEILPSGD-----------RTEIGE 763

Query: 1289 CTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATATSS 1342
             T +++ H ++ +   D I+VM  GK+ E    + L  + G+ FA  + T  S+
Sbjct: 764  KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGA-FAEFLRTYAST 816


>gi|134142340 ATP-binding cassette, sub-family C, member 1 isoform 2
            [Homo sapiens]
          Length = 1472

 Score =  423 bits (1087), Expect = e-118
 Identities = 266/781 (34%), Positives = 410/781 (52%), Gaps = 98/781 (12%)

Query: 630  RGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECI--KKTLRGKTVV 687
            +G+NLSGGQKQR+SLARAVYS+  IYL DDPLSAVDAHVGKHIFE  I  K  L+ KT +
Sbjct: 705  KGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRI 764

Query: 688  LVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAK 747
            LVTH + YL     II++  GKI E G++ EL+ + G +A+ ++     A+++  QD  +
Sbjct: 765  LVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTY---ASTEQEQDAEE 821

Query: 748  IA---------EKPKVESQALAT-----------SLEESLNGNAVPEHQLTQE------- 780
                       E  ++E+  L T           S   S +G+    H  T E       
Sbjct: 822  NGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAK 881

Query: 781  ----------EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYW 830
                      ++ + G +   VY  Y++A G ++    IF F+   V   + S +WLS W
Sbjct: 882  KEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVS-ALASNYWLSLW 940

Query: 831  LEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRK 890
             +      +   +   ++  G +  +  ++    V+G +      + V   GI       
Sbjct: 941  TDDPIVNGTQEHTKVRLSVYGALGISQGIA----VFGYS------MAVSIGGIL------ 984

Query: 891  ASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIA 950
            AS  LH  L + + R PMSFF+  P G L+N F+ +L+ +D ++P   + F+     VI 
Sbjct: 985  ASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIG 1044

Query: 951  VLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLS 1010
              +++ + +P   ++   + +I F     +  +    KRLE+ SRSP++SH   +L G+S
Sbjct: 1045 ACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVS 1104

Query: 1011 SIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGIS 1070
             I  + + E FI Q     D         + + RW+A+RLE + N + L  ALF      
Sbjct: 1105 VIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRH 1164

Query: 1071 STPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTS 1130
            S       ++V+  LQ+ +      R+  E E    AVER+ +Y +    EAP  ++ T+
Sbjct: 1165 SLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET-EKEAPWQIQETA 1223

Query: 1131 CPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFR 1190
             P  WPQ G + F++Y ++YR++   VL  IN+TI G E VGIVGRTG+GKSSL + LFR
Sbjct: 1224 PPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFR 1283

Query: 1191 LVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDA 1250
            + E   G I+IDG++I  IGL DLR K+++IPQDPVL SG++R NLDPF +++D+++W +
Sbjct: 1284 INESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTS 1343

Query: 1251 LE-------------------------------------RTFLTKA-IILIDEATASIDM 1272
            LE                                     R  L K  I+++DEATA++D+
Sbjct: 1344 LELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDL 1403

Query: 1273 ETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLF 1332
            ETD LIQ TIR  F+ CTVL IAHR+ T+++   ++V+  G++ E+  P  L ++ G  +
Sbjct: 1404 ETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFY 1463

Query: 1333 A 1333
            +
Sbjct: 1464 S 1464



 Score =  106 bits (265), Expect = 1e-22
 Identities = 110/540 (20%), Positives = 220/540 (40%), Gaps = 86/540 (15%)

Query: 81  PAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEE 140
           P P P  +A   S +T  W+T L+++  R  L+ + +  L+  D S++ V  L + W++E
Sbjct: 205 PNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKE 264

Query: 141 VSRRGIEKASVL-----------------------LVMLRFQR--TRLIFDAL---LGIC 172
            ++   +   V+                       L++   Q+     +F  L    G  
Sbjct: 265 CAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPY 324

Query: 173 FCIASVLGPI---------LIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSS 223
           F ++     I          I+  ++++  +       G      LF++ C+++L     
Sbjct: 325 FLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQY 384

Query: 224 WIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPLV 281
           + I   + +R + AV    + K +   +    +S  GE ++  + D     +   Y  ++
Sbjct: 385 FHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMI 444

Query: 282 LITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRV 341
                 +++     +  +G +    +   +L+ P+   M       Q    +  D RI++
Sbjct: 445 WSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKL 504

Query: 342 TSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITL----FIIPTVA 397
            +E+L  IK++K+Y WE  F   +  +R++E K+L+K   + ++ + T     F++    
Sbjct: 505 MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCT 564

Query: 398 TAVWVLIHTSLKLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQ 457
            AV+V I  +    L A  AF  LA  N+LR  +  +P+ +  +  +  ++ R + F   
Sbjct: 565 FAVYVTIDEN--NILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSH 622

Query: 458 ES---PVFYVQTLQD--PSKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRD 512
           E         + ++D   + ++    AT +W ++ P  +NG                   
Sbjct: 623 EELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNG------------------- 663

Query: 513 ALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG 572
                            I   + +G ++ V G  G GKSSLLSA+L EM  +EG V ++G
Sbjct: 664 -----------------ITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG 706



 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 65/224 (29%), Positives = 105/224 (46%), Gaps = 18/224 (8%)

Query: 527  LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
            L  IN+ ++ G  +G+ G TG+GKSSL   +       EG + + G              
Sbjct: 1251 LRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFK 1310

Query: 574  LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLN 633
            +  +PQ   + SG++R N+     Y        L    L   +  LP     E  E G N
Sbjct: 1311 ITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGEN 1370

Query: 634  LSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQL 693
            LS GQ+Q + LARA+    +I +LD+  +AVD      + +  I+      TV+ + H+L
Sbjct: 1371 LSVGQRQLVCLARALLRKTKILVLDEATAAVDLET-DDLIQSTIRTQFEDCTVLTIAHRL 1429

Query: 694  QYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEA 737
              +    ++I+L+ G+I E G  S+L+Q++G    L   M K+A
Sbjct: 1430 NTIMDYTRVIVLDKGEIQEYGAPSDLLQQRG----LFYSMAKDA 1469



 Score = 50.8 bits (120), Expect = 9e-06
 Identities = 92/476 (19%), Positives = 186/476 (39%), Gaps = 79/476 (16%)

Query: 890  KASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVI 949
            +  TA+   ++ K      S   +  +G ++N  + D ++   L    +  +     +++
Sbjct: 394  RIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVIL 453

Query: 950  AVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKA----IGVFKRLENYSRSPLFSHILNS 1005
            A+ L+   L P +L   A+++++  +  +M  K     +   K  +N  R  L + ILN 
Sbjct: 454  ALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDN--RIKLMNEILNG 511

Query: 1006 LQGLS--SIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWM-----------ALRLEI 1052
            ++ L   +  +  K +    + + L   + +  L  + +  W+           A+ + I
Sbjct: 512  IKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTI 571

Query: 1053 MTNLVTLAVALFVA---FGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVE 1109
              N +  A   FV+   F I   P +   M ++ ++Q + S +         E +  ++E
Sbjct: 572  DENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIE 631

Query: 1110 RILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHE 1169
            R            P+   G +          I  ++    +  + P  L+GI  +I    
Sbjct: 632  R-----------RPVKDGGGT--------NSITVRNATFTWARSDPPTLNGITFSIPEGA 672

Query: 1170 VVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLS 1229
            +V +VG+ G GKSSL  AL   ++ + G + I GV+            LS   +  V L+
Sbjct: 673  LVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGVN------------LSGGQKQRVSLA 720

Query: 1230 GTIRFNLDPFDRHTDQQIWDALERTFLTKAIILIDEATASIDMETDTLIQRTI---REAF 1286
              +  N D                      I L D+  +++D      I   +   +   
Sbjct: 721  RAVYSNAD----------------------IYLFDDPLSAVDAHVGKHIFENVIGPKGML 758

Query: 1287 QGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATATSS 1342
            +  T +++ H ++ +   D I+VM  GK+ E    + L  + G+ FA  + T  S+
Sbjct: 759  KNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGA-FAEFLRTYAST 813


>gi|157502203 ATP-binding cassette, sub-family C, member 4 isoform 2
           [Homo sapiens]
          Length = 859

 Score =  391 bits (1004), Expect = e-108
 Identities = 272/888 (30%), Positives = 436/888 (49%), Gaps = 81/888 (9%)

Query: 83  PQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEEVS 142
           P PL +A L S +   WL PL     + RL+E+ +  +   D S    + L   W++EV 
Sbjct: 10  PNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVL 69

Query: 143 R--RGIEKASVLLVMLR-FQRTRLIFDALLGICFCI---ASVLGPILIIPKILEYSE--E 194
           R     +K S+   +++ + ++ L+    LGI   I   A V+ PI +  KI+ Y E  +
Sbjct: 70  RAENDAQKPSLTRAIIKCYWKSYLV----LGIFTLIEESAKVIQPIFL-GKIINYFENYD 124

Query: 195 QLGNVVHGVGLCFALFLSECVKSLSFSSSWIIN--QRTAIRFRAAVSSFAFEKLIQFKSV 252
            + +V       +A  L+ C   L+          Q   +R R A+    + K ++  ++
Sbjct: 125 PMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNM 184

Query: 253 I--HITSGEAISFFTGDVNYLFEGVCY------GPLVLITCASLVICSISSYFIIGYTAF 304
                T+G+ ++  + DVN   +   +      GPL  I   +L+      +  IG +  
Sbjct: 185 AMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALL------WMEIGISCL 238

Query: 305 IAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKI 364
             +   +++ PL     ++    +  T+  +D RIR  +EV+T I++IKMY WEK F+ +
Sbjct: 239 AGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNL 298

Query: 365 IEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLASL 424
           I +LR+KE   + +   ++ +   + F    +   V    +  L   +TAS  F  +   
Sbjct: 299 ITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLY 358

Query: 425 NLLRLSV-FFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVF-EEATLS 482
             +RL+V  F P A++ ++ +  ++ R + F L +      + L    K +V  ++ T  
Sbjct: 359 GAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAF 418

Query: 483 WQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLGV 542
           W +                 ASE                   P L  ++  V  G +L V
Sbjct: 419 WDK-----------------ASET------------------PTLQGLSFTVRPGELLAV 443

Query: 543 CGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKAR 602
            G  G+GKSSLLSA+L E+    G V V G +AYV QQ W+ SG +R NIL G  Y+K R
Sbjct: 444 VGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKER 503

Query: 603 YLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLS 662
           Y +V+  C+L +DL+LL  GD+T IG+RG  LSGGQK R++LARAVY D  IYLLDDPLS
Sbjct: 504 YEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLS 563

Query: 663 AVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQK 722
           AVDA V +H+FE CI + L  K  +LVTHQLQYL+   QI++L++GK+ + GT++E ++ 
Sbjct: 564 AVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKS 623

Query: 723 KGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALA-TSLEESLNGNAVPEHQLTQ-- 779
              +  L++K ++E+    +  T  +  +   ES   +  S   SL   A+ E Q T+  
Sbjct: 624 GIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGAL-ESQDTENV 682

Query: 780 -----EEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQG 834
                EE   EG + ++ Y +Y +A   ++V   +           +   WWLSYW    
Sbjct: 683 PVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYW---- 738

Query: 835 SGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTA 894
              N     N T+   GN+ +   L++Y  +Y    +  +  G+  S +   V   +S  
Sbjct: 739 --ANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQT 796

Query: 895 LHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFL 942
           LHNK+F  + + P+ FFD  PIGR+LN F+ D+  LD LLP+    F+
Sbjct: 797 LHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFI 844



 Score = 57.4 bits (137), Expect = 9e-08
 Identities = 75/391 (19%), Positives = 150/391 (38%), Gaps = 46/391 (11%)

Query: 894  ALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLL 953
            A+ + ++ K  R           G+++N  + D+ + DQ+  +F        L  IAV  
Sbjct: 169  AMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVT-VFLHFLWAGPLQAIAVTA 227

Query: 954  IVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIH 1013
            ++ +      L G  +++I       F K     +             +   + G+  I 
Sbjct: 228  LLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIK 287

Query: 1014 VYGKTEDF-----------ISQFKRLTDAQNNYLLLFLSSTR---WMALRLEIMTNLVTL 1059
            +Y   + F           IS+  R +  +   L  F S+++   ++     ++   V  
Sbjct: 288  MYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVIT 347

Query: 1060 AVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCV 1119
            A  +FVA     T Y    + V +    A    + A + +     F  ++ I Q  +   
Sbjct: 348  ASRVFVAV----TLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLP 403

Query: 1120 SEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGS 1179
            S+    +        W +  E             TPT L G++ T+R  E++ +VG  G+
Sbjct: 404  SDGKKMVHVQDFTAFWDKASE-------------TPT-LQGLSFTVRPGELLAVVGPVGA 449

Query: 1180 GKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPF 1239
            GKSSL  A+   + P             S GL  +  +++ + Q P + SGT+R N+   
Sbjct: 450  GKSSLLSAVLGELAP-------------SHGLVSVHGRIAYVSQQPWVFSGTLRSNILFG 496

Query: 1240 DRHTDQQIWDALERTFLTKAIILIDEATASI 1270
             ++  ++    ++   L K + L+++   ++
Sbjct: 497  KKYEKERYEKVIKACALKKDLQLLEDGDLTV 527


>gi|134142342 ATP-binding cassette, sub-family C, member 1 isoform 4
            [Homo sapiens]
          Length = 1416

 Score =  347 bits (889), Expect = 6e-95
 Identities = 225/725 (31%), Positives = 364/725 (50%), Gaps = 96/725 (13%)

Query: 684  KTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQ 743
            KT +LVTH + YL     II++  GKI E G++ EL+ + G +A+ ++     A+++  Q
Sbjct: 705  KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTY---ASTEQEQ 761

Query: 744  DTAKIA---------EKPKVESQALAT-----------SLEESLNGNAVPEHQLTQE--- 780
            D  +           E  ++E+  L T           S   S +G+    H  T E   
Sbjct: 762  DAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQK 821

Query: 781  --------------EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWW 826
                          ++ + G +   VY  Y++A G ++    IF F+   V   + S +W
Sbjct: 822  AEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVS-ALASNYW 880

Query: 827  LSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTK 886
            LS W +      +   +   ++  G +  +  ++    V+G +      + V   GI   
Sbjct: 881  LSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIA----VFGYS------MAVSIGGIL-- 928

Query: 887  VTRKASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSL 946
                AS  LH  L + + R PMSFF+  P G L+N F+ +L+ +D ++P   + F+    
Sbjct: 929  ----ASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLF 984

Query: 947  MVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSL 1006
             VI   +++ + +P   ++   + +I F     +  +    KRLE+ SRSP++SH   +L
Sbjct: 985  NVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETL 1044

Query: 1007 QGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVA 1066
             G+S I  + + E FI Q     D         + + RW+A+RLE + N + L  ALF  
Sbjct: 1045 LGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAV 1104

Query: 1067 FGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHM 1126
                S       ++V+  LQ+ +      R+  E E    AVER+ +Y +    EAP  +
Sbjct: 1105 ISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET-EKEAPWQI 1163

Query: 1127 EGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGM 1186
            + T+ P  WPQ G + F++Y ++YR++   VL  IN+TI G E VGIVGRTG+GKSSL +
Sbjct: 1164 QETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTL 1223

Query: 1187 ALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQ 1246
             LFR+ E   G I+IDG++I  IGL DLR K+++IPQDPVL SG++R NLDPF +++D++
Sbjct: 1224 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEE 1283

Query: 1247 IWDALE-------------------------------------RTFLTKA-IILIDEATA 1268
            +W +LE                                     R  L K  I+++DEATA
Sbjct: 1284 VWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATA 1343

Query: 1269 SIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKP 1328
            ++D+ETD LIQ TIR  F+ CTVL IAHR+ T+++   ++V+  G++ E+  P  L ++ 
Sbjct: 1344 AVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQR 1403

Query: 1329 GSLFA 1333
            G  ++
Sbjct: 1404 GLFYS 1408



 Score =  108 bits (270), Expect = 3e-23
 Identities = 122/600 (20%), Positives = 243/600 (40%), Gaps = 103/600 (17%)

Query: 81  PAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEE 140
           P P P  +A   S +T  W+T L+++  R  L+ + +  L+  D S++ V  L + W++E
Sbjct: 205 PNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKE 264

Query: 141 VSRRGIEKASVL-----------------------LVMLRFQR--TRLIFDAL---LGIC 172
            ++   +   V+                       L++   Q+     +F  L    G  
Sbjct: 265 CAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPY 324

Query: 173 FCIASVLGPI---------LIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSS 223
           F ++     I          I+  ++++  +       G      LF++ C+++L     
Sbjct: 325 FLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQY 384

Query: 224 WIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPLV 281
           + I   + +R + AV    + K +   +    +S  GE ++  + D     +   Y  ++
Sbjct: 385 FHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMI 444

Query: 282 LITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRV 341
                 +++     +  +G +    +   +L+ P+   M       Q    +  D RI++
Sbjct: 445 WSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKL 504

Query: 342 TSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITL----FIIPTVA 397
            +E+L  IK++K+Y WE  F   +  +R++E K+L+K   + ++ + T     F++    
Sbjct: 505 MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCT 564

Query: 398 TAVWVLIHTSLKLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQ 457
            AV+V I  +    L A  AF  LA  N+LR  +  +P+ +  +  +  ++ R + F   
Sbjct: 565 FAVYVTIDEN--NILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSH 622

Query: 458 ES---PVFYVQTLQD--PSKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRD 512
           E         + ++D   + ++    AT +W ++ P  +NG                   
Sbjct: 623 EELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNG------------------- 663

Query: 513 ALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQ- 571
                            I   + +G ++ V G  G GKSSLLSA+L EM  +EG V ++ 
Sbjct: 664 -----------------ITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKT 706

Query: 572 -----GSLAYVPQQAWIV---------SGNIRENILMGGAYDKARYLQVLHCCSLNRDLE 617
                 S++Y+PQ   I+          G+ +E +   GA+  A +L+        +D E
Sbjct: 707 RILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAF--AEFLRTYASTEQEQDAE 764



 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 65/224 (29%), Positives = 105/224 (46%), Gaps = 18/224 (8%)

Query: 527  LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
            L  IN+ ++ G  +G+ G TG+GKSSL   +       EG + + G              
Sbjct: 1195 LRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFK 1254

Query: 574  LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLN 633
            +  +PQ   + SG++R N+     Y        L    L   +  LP     E  E G N
Sbjct: 1255 ITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGEN 1314

Query: 634  LSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQL 693
            LS GQ+Q + LARA+    +I +LD+  +AVD      + +  I+      TV+ + H+L
Sbjct: 1315 LSVGQRQLVCLARALLRKTKILVLDEATAAVDLET-DDLIQSTIRTQFEDCTVLTIAHRL 1373

Query: 694  QYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEA 737
              +    ++I+L+ G+I E G  S+L+Q++G    L   M K+A
Sbjct: 1374 NTIMDYTRVIVLDKGEIQEYGAPSDLLQQRG----LFYSMAKDA 1413



 Score = 39.3 bits (90), Expect = 0.026
 Identities = 64/332 (19%), Positives = 134/332 (40%), Gaps = 41/332 (12%)

Query: 890  KASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVI 949
            +  TA+   ++ K      S   +  +G ++N  + D ++   L    +  +     +++
Sbjct: 394  RIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVIL 453

Query: 950  AVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKA----IGVFKRLENYSRSPLFSHILNS 1005
            A+ L+   L P +L   A+++++  +  +M  K     +   K  +N  R  L + ILN 
Sbjct: 454  ALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDN--RIKLMNEILNG 511

Query: 1006 LQGLS--SIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWM-----------ALRLEI 1052
            ++ L   +  +  K +    + + L   + +  L  + +  W+           A+ + I
Sbjct: 512  IKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTI 571

Query: 1053 MTNLVTLAVALFVA---FGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVE 1109
              N +  A   FV+   F I   P +   M ++ ++Q + S +         E +  ++E
Sbjct: 572  DENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIE 631

Query: 1110 RILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHE 1169
            R            P+   G +          I  ++    +  + P  L+GI  +I    
Sbjct: 632  R-----------RPVKDGGGT--------NSITVRNATFTWARSDPPTLNGITFSIPEGA 672

Query: 1170 VVGIVGRTGSGKSSLGMALFRLVEPMAGRILI 1201
            +V +VG+ G GKSSL  AL   ++ + G + I
Sbjct: 673  LVAVVGQVGCGKSSLLSALLAEMDKVEGHVAI 704


>gi|90421313 cystic fibrosis transmembrane conductance regulator
           [Homo sapiens]
          Length = 1480

 Score =  250 bits (639), Expect = 6e-66
 Identities = 180/642 (28%), Positives = 314/642 (48%), Gaps = 20/642 (3%)

Query: 85  PLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEEVSRR 144
           PL+ A + S L  SW  P++ +  R RL+ + I  +   D++D   ++L R W+ E++ +
Sbjct: 5   PLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASK 64

Query: 145 GIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLGPILIIPKILEYS----EEQLGNVV 200
             +   ++  + R    R +F  +      +   + P+L+   I  Y     EE+   + 
Sbjct: 65  --KNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIY 122

Query: 201 HGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSSFAFEKLIQFKSVI--HITSG 258
            G+GLC  LF+   V++L    +        ++ R A+ S  ++K ++  S +   I+ G
Sbjct: 123 LGIGLCL-LFI---VRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIG 178

Query: 259 EAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAV 318
           + +S  + ++N   EG+     V I    + +     + ++  +AF  +   +++     
Sbjct: 179 QLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQA 238

Query: 319 FMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEK 378
            + RM +K +   +    +R+ +TSE++  I+ +K Y WE+   K+IE+LR+ E KL  K
Sbjct: 239 GLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRK 298

Query: 379 CGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLASLNLLRLSVFF-VPIA 437
              V+   S   F        + VL +  +K  +     F+ ++   +LR++V    P A
Sbjct: 299 AAYVRYFNSSAFFFSGFFVVFLSVLPYALIK-GIILRKIFTTISFCIVLRMAVTRQFPWA 357

Query: 438 VKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALEL 497
           V+   +S  A+ + + F  ++        L   +  +V E  T  W++    +   A + 
Sbjct: 358 VQTWYDSLGAINKIQDFLQKQEYKTLEYNLT--TTEVVMENVTAFWEEGFGELFEKAKQN 415

Query: 498 ERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAI 557
             N   S G     D+L          P L  IN  + +G +L V G+TG+GK+SLL  I
Sbjct: 416 NNNRKTSNG----DDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVI 471

Query: 558 LEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLE 617
           + E+   EG +   G +++  Q +WI+ G I+ENI+ G +YD+ RY  V+  C L  D+ 
Sbjct: 472 MGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDIS 531

Query: 618 LLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECI 677
                D   +GE G+ LSGGQ+ RISLARAVY D  +YLLD P   +D    K IFE C+
Sbjct: 532 KFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCV 591

Query: 678 KKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSEL 719
            K +  KT +LVT ++++L+   +I++L  G     GT SEL
Sbjct: 592 CKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSEL 633



 Score =  233 bits (595), Expect = 7e-61
 Identities = 174/658 (26%), Positives = 302/658 (45%), Gaps = 82/658 (12%)

Query: 731  QKMHKEATSDMLQDTAKIAEKPKVE-----------SQALATSLEESLNGNAVPEHQLTQ 779
            Q +H++ T+     T K++  P+             SQ     + E +N   + E     
Sbjct: 781  QNIHRKTTAS----TRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDD 836

Query: 780  EEEMEEGSLSWRVYHHYIQAAGGY---MVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSG 836
             E +   + +W  Y  YI         ++ C++ F   +   L +   W L     Q  G
Sbjct: 837  MESIPAVT-TWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVL--WLLGNTPLQDKG 893

Query: 837  TNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALH 896
             NS+   N + A +  I        + +  G+ A  L+ +G              S  LH
Sbjct: 894  -NSTHSRNNSYAVI--ITSTSSYYVFYIYVGV-ADTLLAMGFFRGLPLVHTLITVSKILH 949

Query: 897  NKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVS 956
            +K+ + V + PMS  +T+  G +LN F+ D+  LD LLP+    F+ L L+VI  + +V+
Sbjct: 950  HKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVA 1009

Query: 957  VLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYG 1016
            VL PYI +    ++V   +    F +     K+LE+  RSP+F+H++ SL+GL ++  +G
Sbjct: 1010 VLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFG 1069

Query: 1017 KTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSF 1076
            +   F + F +  +       L+LS+ RW  +R+E++  +  +AV  F++   +      
Sbjct: 1070 RQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVT-FISILTTGEGEGR 1128

Query: 1077 KVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAP------------- 1123
              + + + + + S+ Q      ++ ++   +V R+ +++ M     P             
Sbjct: 1129 VGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLS 1188

Query: 1124 --LHMEGTSCPQG--WPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGS 1179
              + +E +   +   WP  G++  +D   KY +    +L  I+ +I   + VG++GRTGS
Sbjct: 1189 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGS 1248

Query: 1180 GKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPF 1239
            GKS+L  A  RL+    G I IDGV   SI L+  R    VIPQ   + SGT R NLDP+
Sbjct: 1249 GKSTLLSAFLRLLN-TEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPY 1307

Query: 1240 DRHTDQQIWD-------------------------------------ALERTFLTKA-II 1261
            ++ +DQ+IW                                       L R+ L+KA I+
Sbjct: 1308 EQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKIL 1367

Query: 1262 LIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFD 1319
            L+DE +A +D  T  +I+RT+++AF  CTV++  HR+  +L C   LV+   KV ++D
Sbjct: 1368 LLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYD 1425



 Score = 90.5 bits (223), Expect = 1e-17
 Identities = 72/263 (27%), Positives = 126/263 (47%), Gaps = 21/263 (7%)

Query: 518  EEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG----- 572
            E GN++   L  I+  +S G  +G+ G TGSGKS+LLSA L  ++  EG + + G     
Sbjct: 1221 EGGNAI---LENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEGEIQIDGVSWDS 1276

Query: 573  --------SLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDM 624
                    +   +PQ+ +I SG  R+N+     +      +V     L   +E  P    
Sbjct: 1277 ITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLD 1336

Query: 625  TEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGK 684
              + + G  LS G KQ + LAR+V S  +I LLD+P + +D  V   I    +K+     
Sbjct: 1337 FVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDP-VTYQIIRRTLKQAFADC 1395

Query: 685  TVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQD 744
            TV+L  H+++ +  C Q +++E  K+ +  +  +L+ ++  + Q I    +       ++
Sbjct: 1396 TVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPH-RN 1454

Query: 745  TAKIAEKPKVESQALATSLEESL 767
            ++K   KP++   AL    EE +
Sbjct: 1455 SSKCKSKPQI--AALKEETEEEV 1475



 Score = 37.4 bits (85), Expect = 0.098
 Identities = 20/53 (37%), Positives = 30/53 (56%), Gaps = 1/53 (1%)

Query: 1157 VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDG-VDICS 1208
            VL  IN  I   +++ + G TG+GK+SL M +   +EP  G+I   G +  CS
Sbjct: 440  VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCS 492


>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
            sapiens]
          Length = 1280

 Score =  179 bits (455), Expect = 1e-44
 Identities = 274/1210 (22%), Positives = 487/1210 (40%), Gaps = 231/1210 (19%)

Query: 258  GEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIGYT-AFIAILCYLLVFPL 316
            GE  +  T DV+ + EG+  G  + +   S+   +  + FI+G+T  +   L  L + P+
Sbjct: 169  GELNTRLTDDVSKINEGI--GDKIGMFFQSMA--TFFTGFIVGFTRGWKLTLVILAISPV 224

Query: 317  AVFMTRMAVKAQHHTSEVSDQRI-------RVTSEVLTCIKLIKMYTWEKPFAKIIEDLR 369
                  +  K     S  +D+ +        V  EVL  I+ +  +  +K      ++L 
Sbjct: 225  LGLSAAVWAKI---LSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQK------KELE 275

Query: 370  RKERKLLE--KCGLVQSLTS------ITLFIIPTVATAVWVLIHTSLKLKLTASMAFSML 421
            R  + L E  + G+ +++T+        L I  + A A W      L  + +     ++ 
Sbjct: 276  RYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVF 335

Query: 422  ASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEATL 481
             S+ +   SV     +++   N++ A     K    +  +                  + 
Sbjct: 336  FSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSI-----------------DSY 378

Query: 482  SWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLG 541
            S     P  + G LE  RN H S           P  +   +   L  +NL V  G  + 
Sbjct: 379  SKSGHKPDNIKGNLEF-RNVHFSY----------PSRKEVKI---LKGLNLKVQSGQTVA 424

Query: 542  VCGNTGSGKSSLLSAILEEMHLLEGSVGVQGS-------------LAYVPQQAWIVSGNI 588
            + GN+G GKS+ +  +       EG V V G              +  V Q+  + +  I
Sbjct: 425  LVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTI 484

Query: 589  RENILMGGAYDKARYLQ-VLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARA 647
             ENI  G        ++  +   +    +  LP    T +GERG  LSGGQKQRI++ARA
Sbjct: 485  AENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARA 544

Query: 648  VYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLEN 707
            +  + +I LLD+  SA+D    + + +  + K  +G+T +++ H+L  +     I   ++
Sbjct: 545  LVRNPKILLLDEATSALDTE-SEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDD 603

Query: 708  GKICENGTHSELMQKKGKYAQLI------QKMHKEATSDMLQ---DTAKIAEKPKVESQA 758
            G I E G H ELM++KG Y +L+       ++  E  +D  +   D  +++      S  
Sbjct: 604  GVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRSSLI 663

Query: 759  LATSLEESLNGNAVPEHQLTQEEEMEEG---SLSWRVYHHYIQAAGGYMVS--CIIFFFV 813
               S   S+ G+   + +L+ +E ++E       WR+    +     ++V   C I    
Sbjct: 664  RKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGG 723

Query: 814  VLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLL 873
            +   F  IFS                       +  +    D+P+    +    L +LL 
Sbjct: 724  LQPAFAIIFS----------------------KIIGVFTRIDDPETK--RQNSNLFSLLF 759

Query: 874  ICVGVCS-------SGIFTKVTRKASTALHNKLFNKVFRCPMSFFD--TIPIGRLLNCFA 924
            + +G+ S          F K     +  L   +F  + R  +S+FD      G L    A
Sbjct: 760  LALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLA 819

Query: 925  GDLEQ----LDQLLPIFSEQFLVLSLMVI-------AVLLIVSVLSPYILLMGAIIMVIC 973
             D  Q    +   L + ++    L   +I        + L++  + P I + G + M + 
Sbjct: 820  NDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKML 879

Query: 974  FIYYMMFKK-----------AIGVFKRLENYSRSPLFSHI-LNSLQ-----GLSSIHVYG 1016
                +  KK           AI  F+ + + ++   F H+   SLQ      L   H++G
Sbjct: 880  SGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFG 939

Query: 1017 KTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSF 1076
             T  F            +Y   F      +A +L  M+    L V   V FG        
Sbjct: 940  ITFSFTQAMMYF-----SYAGCFRFGAYLVAHKL--MSFEDVLLVFSAVVFG-------- 984

Query: 1077 KVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPL----HMEG--TS 1130
              MAV  V   A  +          +A+ +A   I     M + + PL      EG   +
Sbjct: 985  -AMAVGQVSSFAPDY---------AKAKISAAHII-----MIIEKTPLIDSYSTEGLMPN 1029

Query: 1131 CPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFR 1190
              +G    GE++F   +   R + P VL G++L ++  + + +VG +G GKS++   L R
Sbjct: 1030 TLEGNVTFGEVVF---NYPTRPDIP-VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLER 1085

Query: 1191 LVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFD--RHTDQQ-- 1246
              +P+AG++L+DG +I  + ++ LR+ L ++ Q+P+L   +I  N+   D  R   Q+  
Sbjct: 1086 FYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEI 1145

Query: 1247 -----------IWDALERTFLTKA--------------------------IILIDEATAS 1269
                         ++L   + TK                           I+L+DEAT++
Sbjct: 1146 VRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSA 1205

Query: 1270 IDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPG 1329
            +D E++ ++Q  + +A +G T +VIAHR++T+ N D I+V  NG+V E    + L  + G
Sbjct: 1206 LDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKG 1265

Query: 1330 SLFAALMATA 1339
              F+ +   A
Sbjct: 1266 IYFSMVSVQA 1275


>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
            [Homo sapiens]
          Length = 1321

 Score =  167 bits (424), Expect = 5e-41
 Identities = 214/919 (23%), Positives = 381/919 (41%), Gaps = 158/919 (17%)

Query: 527  LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
            L+ +N+V+  G M  + G +G+GKS+ L  I       EG V V G              
Sbjct: 438  LNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQ 497

Query: 574  LAYVPQQAWIVSGNIRENILMGGAYDKAR-YLQVLHCCSLNRDLELLPFGDMTEIGERGL 632
            +  V Q+  + S  I ENI  G         +Q     +    +  LP    T +GE G 
Sbjct: 498  IGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGG 557

Query: 633  NLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQ 692
             +SGGQKQR+++ARA+  + +I LLD   SA+D +  + + +E + K   G T++ V H+
Sbjct: 558  QMSGGQKQRVAIARALIRNPKILLLDMATSALD-NESEAMVQEVLSKIQHGHTIISVAHR 616

Query: 693  LQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI-----------QKMHKEATSDM 741
            L  +     II  E+G   E GTH EL+++KG Y  L+           ++  K+AT D 
Sbjct: 617  LSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQSQGNQALNEEDIKDATEDD 676

Query: 742  L----------QDTAKIAEKPKVESQALATSLEESLNGNAVPEHQLTQEEEMEEGSLSWR 791
            +          QD+ + + + + +SQ      E  L   AV +H+ T EE+ ++  +   
Sbjct: 677  MLARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPL---AVVDHKSTYEEDRKDKDIP-- 731

Query: 792  VYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLG 851
                 ++ A    V  I+ F      ++ + S                    NGT+  L 
Sbjct: 732  -VQEEVEPA---PVRRILKFSAPEWPYMLVGSV---------------GAAVNGTVTPLY 772

Query: 852  NIADNPQLSFYQLV------YGLNALLLICVGVCSSGIFTKVTRKASTALHNKLFNKVFR 905
                +  L  + +         +N + L+ V +    +FT+  +  + A   +L  K  R
Sbjct: 773  AFLFSQILGTFSIPDKEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLR 832

Query: 906  ---------CPMSFFDTI--PIGRLLNCFAGDLEQL-----DQLLPIFSEQFLVLSLMVI 949
                       +++FD +    G L    A D  Q+      Q+  I +    V   M+I
Sbjct: 833  KFGFRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMII 892

Query: 950  A------VLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHIL 1003
            A      + L++    P++ L GA    +   +    K+A+ +  ++ N           
Sbjct: 893  AFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITN----------- 941

Query: 1004 NSLQGLSSIHVYGKTEDFI--------SQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTN 1055
             +L  + ++   GK   FI          FK      N Y   F  +        + +  
Sbjct: 942  EALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANIYGFCFAFA--------QCIMF 993

Query: 1056 LVTLAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYM 1115
            +   A   +  + IS+    F  +   ++  +  S  A  R    T +   A     ++ 
Sbjct: 994  IANSASYRYGGYLISNEGLHFSYV-FRVISAVVLSATALGRAFSYTPSYAKAKISAARFF 1052

Query: 1116 KMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPT-VLHGINLTIRGHEVVGIV 1174
            ++   + P+ +  T+  +     G+I F D    Y     + VL+G++++I   + +  V
Sbjct: 1053 QLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFV 1112

Query: 1175 GRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRF 1234
            G +G GKS+    L R  +P  G+++IDG D   + ++ LRS + ++ Q+PVL + +I  
Sbjct: 1113 GSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMD 1172

Query: 1235 NLD--------PFDR----HTDQQIWDAL-----------------------ERTFLTKA 1259
            N+         P +R        Q+ D +                       +R  + +A
Sbjct: 1173 NIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARA 1232

Query: 1260 II------LIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNG 1313
            I+      L+DEAT+++D E++  +Q  + +A +G T +VIAHR++T+ N D I VM  G
Sbjct: 1233 IVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQG 1292

Query: 1314 KVVEFDRPEVLRKKPGSLF 1332
             V+E    E L  + G+ +
Sbjct: 1293 VVIEKGTHEELMAQKGAYY 1311



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 62/220 (28%), Positives = 110/220 (50%), Gaps = 17/220 (7%)

Query: 527  LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
            L+ +++ +S G  L   G++G GKS+ +  +       +G V + G             +
Sbjct: 1096 LNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSN 1155

Query: 574  LAYVPQQAWIVSGNIRENILMGGAYDKA---RYLQVLHCCSLNRDLELLPFGDMTEIGER 630
            +  V Q+  + + +I +NI  G    +    R +       L+  +  LP    T +G +
Sbjct: 1156 IGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQ 1215

Query: 631  GLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVT 690
            G  LS G+KQRI++ARA+  D +I LLD+  SA+D    K + +  + K   G+T +++ 
Sbjct: 1216 GSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTV-QVALDKAREGRTCIVIA 1274

Query: 691  HQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730
            H+L  ++    I ++  G + E GTH ELM +KG Y +L+
Sbjct: 1275 HRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLV 1314



 Score = 87.8 bits (216), Expect = 6e-17
 Identities = 63/234 (26%), Positives = 114/234 (48%), Gaps = 40/234 (17%)

Query: 1139 GEIIFQDYHMKYRDNTPT-VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197
            GEI F +    Y       +L+ +N+ I+  E+  +VG +G+GKS+    + R  +P  G
Sbjct: 418  GEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEG 477

Query: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNL-------------------DP 1238
             + +DG DI S+ ++ LR ++ ++ Q+PVL S TI  N+                   + 
Sbjct: 478  MVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANA 537

Query: 1239 FDRHTD-QQIWDAL-------------ERTFLTKA------IILIDEATASIDMETDTLI 1278
            ++   D  Q +D L             +R  + +A      I+L+D AT+++D E++ ++
Sbjct: 538  YNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMV 597

Query: 1279 QRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLF 1332
            Q  + +   G T++ +AHR++TV   D I+   +G  VE    E L ++ G  F
Sbjct: 598  QEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYF 651


>gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C
            [Homo sapiens]
          Length = 1232

 Score =  114 bits (285), Expect = 6e-25
 Identities = 68/222 (30%), Positives = 117/222 (52%), Gaps = 17/222 (7%)

Query: 525  PELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGS----------- 573
            P L  ++L V KG  L + G++G GKS+++  +      L G+V + G            
Sbjct: 1003 PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLR 1062

Query: 574  --LAYVPQQAWIVSGNIRENILMGG---AYDKARYLQVLHCCSLNRDLELLPFGDMTEIG 628
              L  V Q+  +   +I ENI  G       +   +      +++  +E LP    T +G
Sbjct: 1063 AQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVG 1122

Query: 629  ERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVL 688
            ++G  LSGGQKQRI++ARA+    QI LLD+  SA+D    K + +E + K   G+T ++
Sbjct: 1123 DKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEK-VVQEALDKAREGRTCIV 1181

Query: 689  VTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730
            + H+L  ++    I++ +NG++ E+GTH +L+ +KG Y  ++
Sbjct: 1182 IAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMV 1223



 Score =  102 bits (253), Expect = 3e-21
 Identities = 69/218 (31%), Positives = 109/218 (50%), Gaps = 15/218 (6%)

Query: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGS------------- 573
           L  +NL V  G  + + G++G GKS+ +  I       EG++ + G              
Sbjct: 412 LKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREI 471

Query: 574 LAYVPQQAWIVSGNIRENILMG-GAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGL 632
           +  V Q+  + S  I ENI  G G        + +   +    +  LP    T +GERG 
Sbjct: 472 IGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGA 531

Query: 633 NLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQ 692
            LSGGQKQRI++ARA+  + +I LLD+  SA+D      + +  + K   G+T +++ H+
Sbjct: 532 QLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV-QAALDKAREGRTTIVIAHR 590

Query: 693 LQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730
           L  +     I   E+G I E G+HSELM+K+G Y +L+
Sbjct: 591 LSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLV 628



 Score =  100 bits (250), Expect = 7e-21
 Identities = 70/244 (28%), Positives = 124/244 (50%), Gaps = 44/244 (18%)

Query: 1139 GEIIFQDYHMKY--RDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMA 1196
            G I F +    Y  R N P VL G++L ++  + + +VG +G GKS++   L R  +P+A
Sbjct: 985  GNITFNEVVFNYPTRANVP-VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLA 1043

Query: 1197 GRILIDGVDICSIGLEDLRSKLSVIPQDPVL-----------------------LSGTIR 1233
            G +L+DG +   + ++ LR++L ++ Q+P+L                       +S    
Sbjct: 1044 GTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKA 1103

Query: 1234 FNLDPF-------------DRHTD----QQIWDALERTFLTK-AIILIDEATASIDMETD 1275
             N+ PF             D+ T     Q+   A+ R  + +  I+L+DEAT+++D E++
Sbjct: 1104 ANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESE 1163

Query: 1276 TLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAAL 1335
             ++Q  + +A +G T +VIAHR++T+ N D I+V  NG+V E    + L  + G  F+ +
Sbjct: 1164 KVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMV 1223

Query: 1336 MATA 1339
               A
Sbjct: 1224 SVQA 1227



 Score =  100 bits (249), Expect = 9e-21
 Identities = 76/247 (30%), Positives = 119/247 (48%), Gaps = 41/247 (16%)

Query: 1139 GEIIFQDYHMKYRDNTPT-VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197
            G + F D H  Y       +L G+NL ++  + V +VG +G GKS+    + RL +P  G
Sbjct: 392  GNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEG 451

Query: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFN---------LDPFDRHTDQ--- 1245
             I IDG DI +  +  LR  + V+ Q+PVL S TI  N         +D   +   +   
Sbjct: 452  TINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANA 511

Query: 1246 --------QIWDAL-------------ERTFLTKA------IILIDEATASIDMETDTLI 1278
                    Q +D L             +R  + +A      I+L+DEAT+++D E++  +
Sbjct: 512  YEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV 571

Query: 1279 QRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAAL-MA 1337
            Q  + +A +G T +VIAHR++TV N D I    +G +VE      L KK G  F  + M 
Sbjct: 572  QAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQ 631

Query: 1338 TATSSLR 1344
            T+ S ++
Sbjct: 632  TSGSQIQ 638


>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
            [Homo sapiens]
          Length = 1279

 Score =  114 bits (285), Expect = 6e-25
 Identities = 68/222 (30%), Positives = 117/222 (52%), Gaps = 17/222 (7%)

Query: 525  PELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGS----------- 573
            P L  ++L V KG  L + G++G GKS+++  +      L G+V + G            
Sbjct: 1050 PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLR 1109

Query: 574  --LAYVPQQAWIVSGNIRENILMGG---AYDKARYLQVLHCCSLNRDLELLPFGDMTEIG 628
              L  V Q+  +   +I ENI  G       +   +      +++  +E LP    T +G
Sbjct: 1110 AQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVG 1169

Query: 629  ERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVL 688
            ++G  LSGGQKQRI++ARA+    QI LLD+  SA+D    K + +E + K   G+T ++
Sbjct: 1170 DKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEK-VVQEALDKAREGRTCIV 1228

Query: 689  VTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730
            + H+L  ++    I++ +NG++ E+GTH +L+ +KG Y  ++
Sbjct: 1229 IAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMV 1270



 Score =  102 bits (253), Expect = 3e-21
 Identities = 69/218 (31%), Positives = 109/218 (50%), Gaps = 15/218 (6%)

Query: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGS------------- 573
           L  +NL V  G  + + G++G GKS+ +  I       EG++ + G              
Sbjct: 412 LKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREI 471

Query: 574 LAYVPQQAWIVSGNIRENILMG-GAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGL 632
           +  V Q+  + S  I ENI  G G        + +   +    +  LP    T +GERG 
Sbjct: 472 IGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGA 531

Query: 633 NLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQ 692
            LSGGQKQRI++ARA+  + +I LLD+  SA+D      + +  + K   G+T +++ H+
Sbjct: 532 QLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV-QAALDKAREGRTTIVIAHR 590

Query: 693 LQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730
           L  +     I   E+G I E G+HSELM+K+G Y +L+
Sbjct: 591 LSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLV 628



 Score =  100 bits (250), Expect = 7e-21
 Identities = 70/244 (28%), Positives = 124/244 (50%), Gaps = 44/244 (18%)

Query: 1139 GEIIFQDYHMKY--RDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMA 1196
            G I F +    Y  R N P VL G++L ++  + + +VG +G GKS++   L R  +P+A
Sbjct: 1032 GNITFNEVVFNYPTRANVP-VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLA 1090

Query: 1197 GRILIDGVDICSIGLEDLRSKLSVIPQDPVL-----------------------LSGTIR 1233
            G +L+DG +   + ++ LR++L ++ Q+P+L                       +S    
Sbjct: 1091 GTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKA 1150

Query: 1234 FNLDPF-------------DRHTD----QQIWDALERTFLTK-AIILIDEATASIDMETD 1275
             N+ PF             D+ T     Q+   A+ R  + +  I+L+DEAT+++D E++
Sbjct: 1151 ANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESE 1210

Query: 1276 TLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAAL 1335
             ++Q  + +A +G T +VIAHR++T+ N D I+V  NG+V E    + L  + G  F+ +
Sbjct: 1211 KVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMV 1270

Query: 1336 MATA 1339
               A
Sbjct: 1271 SVQA 1274



 Score =  100 bits (249), Expect = 9e-21
 Identities = 76/247 (30%), Positives = 119/247 (48%), Gaps = 41/247 (16%)

Query: 1139 GEIIFQDYHMKYRDNTPT-VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197
            G + F D H  Y       +L G+NL ++  + V +VG +G GKS+    + RL +P  G
Sbjct: 392  GNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEG 451

Query: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFN---------LDPFDRHTDQ--- 1245
             I IDG DI +  +  LR  + V+ Q+PVL S TI  N         +D   +   +   
Sbjct: 452  TINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANA 511

Query: 1246 --------QIWDAL-------------ERTFLTKA------IILIDEATASIDMETDTLI 1278
                    Q +D L             +R  + +A      I+L+DEAT+++D E++  +
Sbjct: 512  YEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV 571

Query: 1279 QRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAAL-MA 1337
            Q  + +A +G T +VIAHR++TV N D I    +G +VE      L KK G  F  + M 
Sbjct: 572  QAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQ 631

Query: 1338 TATSSLR 1344
            T+ S ++
Sbjct: 632  TSGSQIQ 638


>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
            [Homo sapiens]
          Length = 1286

 Score =  111 bits (277), Expect = 5e-24
 Identities = 68/229 (29%), Positives = 117/229 (51%), Gaps = 24/229 (10%)

Query: 525  PELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGV-------------- 570
            P L  ++L V KG  L + G++G GKS+++  +      L G+V V              
Sbjct: 1050 PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKK 1109

Query: 571  ------QGSLAYVPQQAWIVSGNIRENILMGG---AYDKARYLQVLHCCSLNRDLELLPF 621
                  +  L  V Q+  +   +I ENI  G       +   +      +++  +E LP 
Sbjct: 1110 LNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPH 1169

Query: 622  GDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTL 681
               T +G++G  LSGGQKQRI++ARA+    QI LLD+  SA+D    K + +E + K  
Sbjct: 1170 KYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEK-VVQEALDKAR 1228

Query: 682  RGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730
             G+T +++ H+L  ++    I++ +NG++ E+GTH +L+ +KG Y  ++
Sbjct: 1229 EGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMV 1277



 Score =  102 bits (253), Expect = 3e-21
 Identities = 69/218 (31%), Positives = 109/218 (50%), Gaps = 15/218 (6%)

Query: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGS------------- 573
           L  +NL V  G  + + G++G GKS+ +  I       EG++ + G              
Sbjct: 412 LKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREI 471

Query: 574 LAYVPQQAWIVSGNIRENILMG-GAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGL 632
           +  V Q+  + S  I ENI  G G        + +   +    +  LP    T +GERG 
Sbjct: 472 IGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGA 531

Query: 633 NLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQ 692
            LSGGQKQRI++ARA+  + +I LLD+  SA+D      + +  + K   G+T +++ H+
Sbjct: 532 QLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV-QAALDKAREGRTTIVIAHR 590

Query: 693 LQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730
           L  +     I   E+G I E G+HSELM+K+G Y +L+
Sbjct: 591 LSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLV 628



 Score =  100 bits (249), Expect = 9e-21
 Identities = 76/247 (30%), Positives = 119/247 (48%), Gaps = 41/247 (16%)

Query: 1139 GEIIFQDYHMKYRDNTPT-VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197
            G + F D H  Y       +L G+NL ++  + V +VG +G GKS+    + RL +P  G
Sbjct: 392  GNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEG 451

Query: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFN---------LDPFDRHTDQ--- 1245
             I IDG DI +  +  LR  + V+ Q+PVL S TI  N         +D   +   +   
Sbjct: 452  TINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANA 511

Query: 1246 --------QIWDAL-------------ERTFLTKA------IILIDEATASIDMETDTLI 1278
                    Q +D L             +R  + +A      I+L+DEAT+++D E++  +
Sbjct: 512  YEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV 571

Query: 1279 QRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAAL-MA 1337
            Q  + +A +G T +VIAHR++TV N D I    +G +VE      L KK G  F  + M 
Sbjct: 572  QAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQ 631

Query: 1338 TATSSLR 1344
            T+ S ++
Sbjct: 632  TSGSQIQ 638



 Score = 94.0 bits (232), Expect = 9e-19
 Identities = 70/251 (27%), Positives = 124/251 (49%), Gaps = 51/251 (20%)

Query: 1139 GEIIFQDYHMKY--RDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMA 1196
            G I F +    Y  R N P VL G++L ++  + + +VG +G GKS++   L R  +P+A
Sbjct: 1032 GNITFNEVVFNYPTRANVP-VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLA 1090

Query: 1197 GRI-------LIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIR---------------- 1233
            G +       L+DG +   + ++ LR++L ++ Q+P+L   +I                 
Sbjct: 1091 GTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDE 1150

Query: 1234 -------FNLDPF-------------DRHTD----QQIWDALERTFLTKA-IILIDEATA 1268
                    N+ PF             D+ T     Q+   A+ R  + +  I+L+DEAT+
Sbjct: 1151 IVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATS 1210

Query: 1269 SIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKP 1328
            ++D E++ ++Q  + +A +G T +VIAHR++T+ N D I+V  NG+V E    + L  + 
Sbjct: 1211 ALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQK 1270

Query: 1329 GSLFAALMATA 1339
            G  F+ +   A
Sbjct: 1271 GIYFSMVSVQA 1281


>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
           sapiens]
          Length = 738

 Score =  110 bits (274), Expect = 1e-23
 Identities = 72/229 (31%), Positives = 122/229 (53%), Gaps = 25/229 (10%)

Query: 525 PELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG------------ 572
           P     +L +  G +  + G +GSGKS++LS +L       G++ + G            
Sbjct: 508 PIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLR 567

Query: 573 -SLAYVPQQAWIVSGNIRENILMGG-------AYDKARYLQVLHCCSLNRDLELLPFGDM 624
             +  V Q+  + S +I ENI  G        A +  R  +V +  +  R+    P G  
Sbjct: 568 SKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNF---PQGFN 624

Query: 625 TEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGK 684
           T +GE+G+ LSGGQKQRI++ARA+  + +I LLD+  SA+DA   +++ +E + + + G+
Sbjct: 625 TVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAE-NEYLVQEALDRLMDGR 683

Query: 685 TVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQK-KGKYAQLIQK 732
           TV+++ H+L  ++    + +L+ GKI E G H EL+ K  G Y +L+ K
Sbjct: 684 TVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNK 732



 Score =  109 bits (273), Expect = 2e-23
 Identities = 130/557 (23%), Positives = 236/557 (42%), Gaps = 88/557 (15%)

Query: 850  LGNIAD----NPQLSFY----QLVYGLNALLLICVGVCSSGIFTKVT--RKASTALHNKL 899
            LG I D    NP + +     +L  GL+A+ L      +  ++   T  ++    L   L
Sbjct: 192  LGKIIDVIYTNPTVDYSDNLTRLCLGLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSL 251

Query: 900  FNKVFRCPMSFFDTIPIGRLLNCFAGDL--------EQLDQLLPIFSEQFLVLSLMVIAV 951
            F+ + R  ++FFD    G L+N  + D         E L   L   ++  + +S+M    
Sbjct: 252  FSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMM---- 307

Query: 952  LLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSS 1011
              +   L+ ++L +   + +I  IY    +K   V +  ++ +++   +     +  + +
Sbjct: 308  FFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQ--DSLAQATQLAE--ERIGNVRT 363

Query: 1012 IHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISS 1071
            +  +GK    I ++    D           +         +  NL+ L+V       + S
Sbjct: 364  VRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGS 423

Query: 1072 TPY------SFKVMA--VNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAP 1123
                     SF + A  V I +   SSF +    GL    +    E + +  K+  +E  
Sbjct: 424  AHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLW--ELLEREPKLPFNEGV 481

Query: 1124 LHMEGTSCPQGWPQHGEIIFQDYHMKY--RDNTPTVLHGINLTIRGHEVVGIVGRTGSGK 1181
            +  E +         G + F++ H  Y  R   P +    +L+I    V  +VG +GSGK
Sbjct: 482  ILNEKSF-------QGALEFKNVHFAYPARPEVP-IFQDFSLSIPSGSVTALVGPSGSGK 533

Query: 1182 SSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNL----- 1236
            S++   L RL +P +G I +DG DI  +    LRSK+  + Q+P+L S +I  N+     
Sbjct: 534  STVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGAD 593

Query: 1237 DPFDRHTDQ-----QIWDAL--------------------------ERTFLTKA------ 1259
            DP     ++     ++ +A+                          +R  + +A      
Sbjct: 594  DPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPK 653

Query: 1260 IILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFD 1319
            I+L+DEAT+++D E + L+Q  +     G TVLVIAHR++T+ N + + V+  GK+ E+ 
Sbjct: 654  ILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYG 713

Query: 1320 RPEVLRKKPGSLFAALM 1336
            + E L  KP  ++  LM
Sbjct: 714  KHEELLSKPNGIYRKLM 730


>gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo
           sapiens]
          Length = 812

 Score =  105 bits (262), Expect = 3e-22
 Identities = 68/223 (30%), Positives = 119/223 (53%), Gaps = 23/223 (10%)

Query: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
           L  ++L + +G  +   G++G GKS+ +  +      ++G V   G              
Sbjct: 588 LRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQ 647

Query: 574 LAYVPQQAWIVSGNIRENILMGGAYDKARYL------QVLHCCSLNRDLELLPFGDMTEI 627
           +A VPQ+  + + +I ENI  G   D +R +      +  +  +++  +E LP    T++
Sbjct: 648 IAIVPQEPVLFNCSIAENIAYG---DNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQV 704

Query: 628 GERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVV 687
           G +G  LSGGQKQR+++ARA+    +I LLD+  SA+D    K + +  + K   G+T +
Sbjct: 705 GLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEK-VVQHALDKARTGRTCL 763

Query: 688 LVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730
           +VTH+L  ++    I++L NGKI E GTH EL++ +  Y +L+
Sbjct: 764 VVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLV 806



 Score = 96.3 bits (238), Expect = 2e-19
 Identities = 61/202 (30%), Positives = 106/202 (52%), Gaps = 41/202 (20%)

Query: 1157 VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRS 1216
            +L G++L+I   + V  VG +G GKS+    L RL +P+ G++L DGVD   + ++ LRS
Sbjct: 587  ILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRS 646

Query: 1217 KLSVIPQDPVLLSGTIRFNLD--------PFDRHTD------------------------ 1244
            +++++PQ+PVL + +I  N+         P D   +                        
Sbjct: 647  QIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGL 706

Query: 1245 --------QQIWDALERTFLTK-AIILIDEATASIDMETDTLIQRTIREAFQGCTVLVIA 1295
                    Q+   A+ R  L K  I+L+DEAT+++D +++ ++Q  + +A  G T LV+ 
Sbjct: 707  KGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVT 766

Query: 1296 HRVTTVLNCDHILVMGNGKVVE 1317
            HR++ + N D I+V+ NGK+ E
Sbjct: 767  HRLSAIQNADLIVVLHNGKIKE 788



 Score = 89.0 bits (219), Expect = 3e-17
 Identities = 52/153 (33%), Positives = 87/153 (56%), Gaps = 17/153 (11%)

Query: 625 TEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGK 684
           T +GE+G  +SGGQKQRI++ARA+  + +I +LD+  SA+D+   K   +  ++K  +G+
Sbjct: 71  TLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSE-SKSAVQAALEKASKGR 129

Query: 685 TVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQD 744
           T ++V H+L  +     I+ L++G + E G H+ELM K+G Y  L+          M QD
Sbjct: 130 TTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLV----------MSQD 179

Query: 745 TAKIAEKPKVESQALATSLEESLNGNAVPEHQL 777
             K  E  ++ES   +T  +     N++P H +
Sbjct: 180 IKKADE--QMESMTYSTERKT----NSLPLHSV 206



 Score = 57.8 bits (138), Expect = 7e-08
 Identities = 40/177 (22%), Positives = 80/177 (45%), Gaps = 39/177 (22%)

Query: 1200 LIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNL-----DPFDRHTDQQIWDALERT 1254
            ++D  DI ++ +   R  + V+ Q+PVL   TI  N+     D  D   ++   +A    
Sbjct: 1    MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYD 60

Query: 1255 FLTK----------------------------------AIILIDEATASIDMETDTLIQR 1280
            F+ +                                   I+++DEAT+++D E+ + +Q 
Sbjct: 61   FIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQA 120

Query: 1281 TIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMA 1337
             + +A +G T +V+AHR++T+ + D I+ + +G + E      L  K G  ++ +M+
Sbjct: 121  ALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMS 177


>gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo
            sapiens]
          Length = 753

 Score =  105 bits (262), Expect = 3e-22
 Identities = 76/248 (30%), Positives = 119/248 (47%), Gaps = 40/248 (16%)

Query: 1136 PQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPM 1195
            PQ   + F + H +Y +    VL GI+  +   + V IVG +GSGKS++   LFR  EP 
Sbjct: 468  PQTATVAFDNVHFEYIEGQK-VLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQ 526

Query: 1196 AGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNL-------DPFDRHT----- 1243
             G I + G +I  + LE LR  + V+PQD VL   TI +NL        P + +      
Sbjct: 527  KGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLA 586

Query: 1244 -------------DQQIWD-------------ALERTFL-TKAIILIDEATASIDMETDT 1276
                         D Q+ +             A+ R  L    +IL DEAT+S+D  T+ 
Sbjct: 587  GLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEE 646

Query: 1277 LIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALM 1336
             I   +++  +  T + IAHR++TV++ D I+V+  GKV E      L   P S+++ + 
Sbjct: 647  TILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMW 706

Query: 1337 ATATSSLR 1344
             T +S ++
Sbjct: 707  HTQSSRVQ 714



 Score = 99.0 bits (245), Expect = 3e-20
 Identities = 67/256 (26%), Positives = 124/256 (48%), Gaps = 18/256 (7%)

Query: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
           L  I+  V  G  + + G +GSGKS+++  +       +GS+ + G             +
Sbjct: 489 LSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRA 548

Query: 574 LAYVPQQAWIVSGNIRENILMGG-AYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGL 632
           +  VPQ A +    I  N+L G  +        V     L+  +  +P G  T++GERGL
Sbjct: 549 VGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGL 608

Query: 633 NLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQ 692
            LSGG+KQR+++ARA+  D  + L D+  S++D+ + +      +K  ++ +T + + H+
Sbjct: 609 KLSGGEKQRVAIARAILKDPPVILYDEATSSLDS-ITEETILGAMKDVVKHRTSIFIAHR 667

Query: 693 LQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAK-IAEK 751
           L  +    +II+L+ GK+ E GTH  L+     ++   +  H +++     D  K  A+K
Sbjct: 668 LSTVVDADEIIVLDQGKVAERGTHHGLL--ANPHSIYSEMWHTQSSRVQNHDNPKWEAKK 725

Query: 752 PKVESQALATSLEESL 767
             +  +     L+E +
Sbjct: 726 ENISKEEERKKLQEEI 741


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.138    0.409 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,663,243
Number of Sequences: 37866
Number of extensions: 2031132
Number of successful extensions: 8227
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 75
Number of HSP's successfully gapped in prelim test: 38
Number of HSP's that attempted gapping in prelim test: 7625
Number of HSP's gapped (non-prelim): 388
length of query: 1344
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1230
effective length of database: 13,930,794
effective search space: 17134876620
effective search space used: 17134876620
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press