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Search of human proteins with 21687048
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21687048 WD repeat domain 31 isoform 3 [Homo sapiens]
(366 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21687048 WD repeat domain 31 isoform 3 [Homo sapiens] 753 0.0
gi|59938780 WD repeat domain 31 isoform 1 [Homo sapiens] 748 0.0
gi|113865883 WD repeat domain 38 [Homo sapiens] 91 1e-18
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 84 2e-16
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 84 2e-16
gi|32189425 WD repeat domain 69 [Homo sapiens] 84 2e-16
gi|16554629 WD repeat domain 5 [Homo sapiens] 82 6e-16
gi|16554627 WD repeat domain 5 [Homo sapiens] 82 6e-16
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 78 1e-14
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 78 1e-14
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 77 2e-14
gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Hom... 77 3e-14
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 76 5e-14
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 75 7e-14
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 75 9e-14
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 75 9e-14
gi|23199987 WD repeat domain 5B [Homo sapiens] 74 2e-13
gi|55743108 ATG16 autophagy related 16-like 2 [Homo sapiens] 73 4e-13
gi|21071067 TBP-associated factor 5 [Homo sapiens] 72 6e-13
gi|26665869 WD repeat domain 51B [Homo sapiens] 72 8e-13
gi|4505731 peroxisomal biogenesis factor 7 [Homo sapiens] 71 2e-12
gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)... 67 2e-11
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 66 4e-11
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 66 4e-11
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 66 4e-11
gi|8923881 WD SOCS-box protein 2 [Homo sapiens] 66 6e-11
gi|153791298 mitogen-activated protein kinase organizer 1 [Homo ... 65 7e-11
gi|14150114 mitogen-activated protein kinase organizer 1 [Homo s... 65 7e-11
gi|13129110 WD repeat domain 77 [Homo sapiens] 65 1e-10
gi|19913367 transducin beta-like 1Y [Homo sapiens] 64 2e-10
>gi|21687048 WD repeat domain 31 isoform 3 [Homo sapiens]
Length = 366
Score = 753 bits (1944), Expect = 0.0
Identities = 366/366 (100%), Positives = 366/366 (100%)
Query: 1 MLLLRCQLKQAPPQKVSFRFCVVMGKQQSKLKHSTYKYGPDEIIEERIQTKAFQEYSPAH 60
MLLLRCQLKQAPPQKVSFRFCVVMGKQQSKLKHSTYKYGPDEIIEERIQTKAFQEYSPAH
Sbjct: 1 MLLLRCQLKQAPPQKVSFRFCVVMGKQQSKLKHSTYKYGPDEIIEERIQTKAFQEYSPAH 60
Query: 61 MDTVSVVAALNSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSA 120
MDTVSVVAALNSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSA
Sbjct: 61 MDTVSVVAALNSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSA 120
Query: 121 SRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSV 180
SRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSV
Sbjct: 121 SRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSV 180
Query: 181 ERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVD 240
ERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVD
Sbjct: 181 ERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVD 240
Query: 241 GHKCISCSNGFGGEGCEATLWDLRQTRNRICEYKGHFQTVASCVFLPRALALMPLIATSS 300
GHKCISCSNGFGGEGCEATLWDLRQTRNRICEYKGHFQTVASCVFLPRALALMPLIATSS
Sbjct: 241 GHKCISCSNGFGGEGCEATLWDLRQTRNRICEYKGHFQTVASCVFLPRALALMPLIATSS 300
Query: 301 HDCKVKIWNQDTGACLFTLSLDGSGPLTSLAVGDAISLLCASFNRGIHLLRMDHSQGLEL 360
HDCKVKIWNQDTGACLFTLSLDGSGPLTSLAVGDAISLLCASFNRGIHLLRMDHSQGLEL
Sbjct: 301 HDCKVKIWNQDTGACLFTLSLDGSGPLTSLAVGDAISLLCASFNRGIHLLRMDHSQGLEL 360
Query: 361 QEVAAF 366
QEVAAF
Sbjct: 361 QEVAAF 366
>gi|59938780 WD repeat domain 31 isoform 1 [Homo sapiens]
Length = 367
Score = 748 bits (1932), Expect = 0.0
Identities = 366/367 (99%), Positives = 366/367 (99%), Gaps = 1/367 (0%)
Query: 1 MLLLRCQLKQAPPQKVSFRFCVVMGKQQSKLKHSTYKYG-PDEIIEERIQTKAFQEYSPA 59
MLLLRCQLKQAPPQKVSFRFCVVMGKQQSKLKHSTYKYG PDEIIEERIQTKAFQEYSPA
Sbjct: 1 MLLLRCQLKQAPPQKVSFRFCVVMGKQQSKLKHSTYKYGRPDEIIEERIQTKAFQEYSPA 60
Query: 60 HMDTVSVVAALNSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFS 119
HMDTVSVVAALNSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFS
Sbjct: 61 HMDTVSVVAALNSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFS 120
Query: 120 ASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQS 179
ASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQS
Sbjct: 121 ASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQS 180
Query: 180 VERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSV 239
VERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSV
Sbjct: 181 VERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSV 240
Query: 240 DGHKCISCSNGFGGEGCEATLWDLRQTRNRICEYKGHFQTVASCVFLPRALALMPLIATS 299
DGHKCISCSNGFGGEGCEATLWDLRQTRNRICEYKGHFQTVASCVFLPRALALMPLIATS
Sbjct: 241 DGHKCISCSNGFGGEGCEATLWDLRQTRNRICEYKGHFQTVASCVFLPRALALMPLIATS 300
Query: 300 SHDCKVKIWNQDTGACLFTLSLDGSGPLTSLAVGDAISLLCASFNRGIHLLRMDHSQGLE 359
SHDCKVKIWNQDTGACLFTLSLDGSGPLTSLAVGDAISLLCASFNRGIHLLRMDHSQGLE
Sbjct: 301 SHDCKVKIWNQDTGACLFTLSLDGSGPLTSLAVGDAISLLCASFNRGIHLLRMDHSQGLE 360
Query: 360 LQEVAAF 366
LQEVAAF
Sbjct: 361 LQEVAAF 367
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 91.3 bits (225), Expect = 1e-18
Identities = 71/256 (27%), Positives = 116/256 (45%), Gaps = 23/256 (8%)
Query: 71 NSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWD 130
+ + ++G +D V + ++G ++ R GH + P F SAS D V +WD
Sbjct: 32 DGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWD 91
Query: 131 LHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVV 190
+ ++ + L GH V ++ SPDS QL +G D ++LWDV +GQ + R+ +
Sbjct: 92 V-ARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSI 150
Query: 191 THLCWVPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHK------C 244
+ P + S D T+ +WD R + PA H +++GH C
Sbjct: 151 QSSDFSPTVNCLATGSWDSTVHIWDLR-----MVTPAVSH------QALEGHSANISCLC 199
Query: 245 ISCSNGFGGEGCEATLWDLRQTRNR-ICEYKGHFQTVASCVFLPRALALMPLIATSSHDC 303
S S + T+ + T + + + KGH V S F P L L A++ +
Sbjct: 200 YSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWL----ASAGYSR 255
Query: 304 KVKIWNQDTGACLFTL 319
VK+W+ +TG CL TL
Sbjct: 256 MVKVWDCNTGKCLETL 271
Score = 54.3 bits (129), Expect = 2e-07
Identities = 56/208 (26%), Positives = 80/208 (38%), Gaps = 12/208 (5%)
Query: 144 HAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYIL 203
H V A SPD L TGS D + W+ +GQ + R V + P
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 204 QTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCISCSNGFGGEGCEATLWDL 263
S D T+RLWD + + Q S D + S GG LWD+
Sbjct: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLAS-----GGWDKRVMLWDV 134
Query: 264 RQTRNRICEYKGHFQTVASCVFLPRALALMPLIATSSHDCKVKIWN-QDTGACLFTLSLD 322
Q+ + GH ++ S F P L AT S D V IW+ + + +L+
Sbjct: 135 -QSGQMLRLLVGHRDSIQSSDFSPTVNCL----ATGSWDSTVHIWDLRMVTPAVSHQALE 189
Query: 323 GSGPLTSLAVGDAISLLCA-SFNRGIHL 349
G S A LL + S+++ IH+
Sbjct: 190 GHSANISCLCYSASGLLASGSWDKTIHI 217
Score = 47.4 bits (111), Expect = 2e-05
Identities = 32/109 (29%), Positives = 50/109 (45%), Gaps = 1/109 (0%)
Query: 60 HMDTVSVVAALNSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFS 119
H +S + S L SG DKT+ + T +++ + KGH + +A P S
Sbjct: 191 HSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLAS 250
Query: 120 ASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNT 168
A RMV +WD + + + + L G V A +PD L +G+ D T
Sbjct: 251 AGYSRMVKVWDCN-TGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQT 298
Score = 41.2 bits (95), Expect = 0.001
Identities = 43/197 (21%), Positives = 70/197 (35%), Gaps = 44/197 (22%)
Query: 60 HMDTVSVVA-ALNSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFF 118
H +V V+ + +S SGG DK V+ ++ ++G +++ GH I P +
Sbjct: 104 HQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLA 163
Query: 119 SASRDRMVMMWDLH------------GSSQPRQQLC------------------------ 142
+ S D V +WDL G S LC
Sbjct: 164 TGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTS 223
Query: 143 -------GHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCW 195
GH V +A SPD L + + +WD TG+ +E +V +
Sbjct: 224 SLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAF 283
Query: 196 VPREPYILQTSEDKTLR 212
P ++ + D+T R
Sbjct: 284 TPDGKILVSGAADQTRR 300
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 84.3 bits (207), Expect = 2e-16
Identities = 76/289 (26%), Positives = 121/289 (41%), Gaps = 29/289 (10%)
Query: 52 AFQEYSPAHMDTVSVVA-ALNSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVAC 110
+ + + H D V+ V ++N+ SG D ++ ++ K + RF GH+ +T V
Sbjct: 10 SLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNF 69
Query: 111 IPKSSQFFSASRDRMVMMW--DLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNT 168
P S SRD+ V +W ++ G S + H V + D T S D T
Sbjct: 70 SPSGHLLASGSRDKTVRIWVPNVKGESTVFR---AHTATVRSVHFCSDGQSFVTASDDKT 126
Query: 169 LLLWDVVTGQSVERASVSRNVVTHLCWV------PREPYILQTSEDKTLRLWDSRGLQVA 222
+ +W + R ++ H+ WV P I+ S+DKT++LWD +
Sbjct: 127 VKVW------ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180
Query: 223 HMFPAKQHIQTYCEVSVDGHKCISCSNGFGGEGCEATLWDLRQTRNRICEYKGHFQTVAS 282
H + TY VD H +C G + +WD+R T + Y+ H V
Sbjct: 181 HSYCEHGGFVTY----VDFHPSGTCIAAAGMDN-TVKVWDVR-THRLLQHYQLHSAAVNG 234
Query: 283 CVFLPRALALMPLIATSSHDCKVKIWNQDTGACLFTLSLDGSGPLTSLA 331
F P L+ T+S D +KI + G L+TL GP T++A
Sbjct: 235 LSFHPSGNYLI----TASSDSTLKILDLMEGRLLYTLH-GHQGPATTVA 278
Score = 51.6 bits (122), Expect = 1e-06
Identities = 36/143 (25%), Positives = 62/143 (43%), Gaps = 1/143 (0%)
Query: 74 LCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWDLHG 133
L VS DKTV ++ + V + H +T V P + +A D V +WD+
Sbjct: 159 LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR- 217
Query: 134 SSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHL 193
+ + Q H+ V GL+ P + L T S D+TL + D++ G+ + + T +
Sbjct: 218 THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV 277
Query: 194 CWVPREPYILQTSEDKTLRLWDS 216
+ Y D+ + +W S
Sbjct: 278 AFSRTGEYFASGGSDEQVMVWKS 300
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 84.3 bits (207), Expect = 2e-16
Identities = 76/289 (26%), Positives = 121/289 (41%), Gaps = 29/289 (10%)
Query: 52 AFQEYSPAHMDTVSVVA-ALNSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVAC 110
+ + + H D V+ V ++N+ SG D ++ ++ K + RF GH+ +T V
Sbjct: 10 SLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNF 69
Query: 111 IPKSSQFFSASRDRMVMMW--DLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNT 168
P S SRD+ V +W ++ G S + H V + D T S D T
Sbjct: 70 SPSGHLLASGSRDKTVRIWVPNVKGESTVFR---AHTATVRSVHFCSDGQSFVTASDDKT 126
Query: 169 LLLWDVVTGQSVERASVSRNVVTHLCWV------PREPYILQTSEDKTLRLWDSRGLQVA 222
+ +W + R ++ H+ WV P I+ S+DKT++LWD +
Sbjct: 127 VKVW------ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180
Query: 223 HMFPAKQHIQTYCEVSVDGHKCISCSNGFGGEGCEATLWDLRQTRNRICEYKGHFQTVAS 282
H + TY VD H +C G + +WD+R T + Y+ H V
Sbjct: 181 HSYCEHGGFVTY----VDFHPSGTCIAAAGMDN-TVKVWDVR-THRLLQHYQLHSAAVNG 234
Query: 283 CVFLPRALALMPLIATSSHDCKVKIWNQDTGACLFTLSLDGSGPLTSLA 331
F P L+ T+S D +KI + G L+TL GP T++A
Sbjct: 235 LSFHPSGNYLI----TASSDSTLKILDLMEGRLLYTLH-GHQGPATTVA 278
Score = 51.6 bits (122), Expect = 1e-06
Identities = 36/143 (25%), Positives = 62/143 (43%), Gaps = 1/143 (0%)
Query: 74 LCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWDLHG 133
L VS DKTV ++ + V + H +T V P + +A D V +WD+
Sbjct: 159 LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR- 217
Query: 134 SSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHL 193
+ + Q H+ V GL+ P + L T S D+TL + D++ G+ + + T +
Sbjct: 218 THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV 277
Query: 194 CWVPREPYILQTSEDKTLRLWDS 216
+ Y D+ + +W S
Sbjct: 278 AFSRTGEYFASGGSDEQVMVWKS 300
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 84.3 bits (207), Expect = 2e-16
Identities = 78/271 (28%), Positives = 121/271 (44%), Gaps = 31/271 (11%)
Query: 60 HMDTVSVVAALN--SDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQF 117
H + V +A N D +G DKT ++ +TG F+GH EI ++ P+S+
Sbjct: 133 HRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLV 192
Query: 118 FSASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTG 177
+ S D +WD+ + L GH+ + L+ + ++ TGS D+T+++WD TG
Sbjct: 193 ATGSMDTTAKLWDIQNGEEV-YTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTG 251
Query: 178 QSV--------ERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWD-SRGLQVAHMFPAK 228
+ V E +S S N L IL S DKT +LWD + G VA +
Sbjct: 252 RKVNILIGHCAEISSASFNWDCSL--------ILTGSMDKTCKLWDATNGKCVATLTGHD 303
Query: 229 QHIQTYCEVSVDGHKCISCSNGFGGEGCEATLWDLRQTRNRICEYKGHFQTVASCVFLPR 288
I C G K I+ ++ G A ++ TR I + +GH ++ F P+
Sbjct: 304 DEILDSC-FDYTG-KLIATASADG----TARIFS-AATRKCIAKLEGHEGEISKISFNPQ 356
Query: 289 ALALMPLIATSSHDCKVKIWNQDTGACLFTL 319
L+ T S D +IW+ TG CL L
Sbjct: 357 GNHLL----TGSSDKTARIWDAQTGQCLQVL 383
Score = 68.9 bits (167), Expect = 7e-12
Identities = 66/261 (25%), Positives = 101/261 (38%), Gaps = 22/261 (8%)
Query: 96 KRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAV-S 154
K K H +T VA S F + S DR +WD S + L GH VV +A +
Sbjct: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDT-ASGEELNTLEGHRNVVYAIAFNN 144
Query: 155 PDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLW 214
P ++ TGS D T LW V TG+ + L + P+ + S D T +LW
Sbjct: 145 PYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLW 204
Query: 215 DSRGLQVAHMFPAKQHIQTYCEVSVDGHKCISCSNGFGGEGCEATLWDLRQTRNRICEYK 274
D + + + + G + I+ G +WD T ++
Sbjct: 205 DIQNGEEVYTLRGHSAEIISLSFNTSGDRIIT-----GSFDHTVVVWD-ADTGRKVNILI 258
Query: 275 GHFQTVASCVFLPRALALMPLIATSSHDCKVKIWNQDTGACLFTLS----------LDGS 324
GH ++S F LI T S D K+W+ G C+ TL+ D +
Sbjct: 259 GHCAEISSASFNWDC----SLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYT 314
Query: 325 GPLTSLAVGDAISLLCASFNR 345
G L + A D + + ++ R
Sbjct: 315 GKLIATASADGTARIFSAATR 335
Score = 52.8 bits (125), Expect = 5e-07
Identities = 28/99 (28%), Positives = 49/99 (49%), Gaps = 1/99 (1%)
Query: 74 LCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWDLHG 133
L + D T ++ T + + +GHE EI+K++ P+ + + S D+ +WD
Sbjct: 317 LIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQ- 375
Query: 134 SSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLW 172
+ Q Q L GH + A + + + TGS+DNT +W
Sbjct: 376 TGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 82.4 bits (202), Expect = 6e-16
Identities = 71/264 (26%), Positives = 121/264 (45%), Gaps = 14/264 (5%)
Query: 53 FQEYSPAHMDTVSVVA-ALNSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACI 111
F++ H +S VA + +S+L VS DKT+ ++ +G +K KGH + +
Sbjct: 79 FEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFN 138
Query: 112 PKSSQFFSASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLL 171
P+S+ S S D V +WD+ + + + L H+ V+ + + D S + + S D +
Sbjct: 139 PQSNLIVSGSFDESVRIWDVK-TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRI 197
Query: 172 WDVVTGQSVERASVSRN-VVTHLCWVPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQH 230
WD +GQ ++ N V+ + + P YIL + D TL+LWD + + ++
Sbjct: 198 WDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKN 257
Query: 231 IQTYC---EVSVDGHKCISCSNGFGGEGCEATLWDLRQTRNRICEYKGHFQTVASCVFLP 287
+ YC SV G K I G E +W+L QT+ + + +GH V S P
Sbjct: 258 -EKYCIFANFSVTGGKWIVS----GSEDNLVYIWNL-QTKEIVQKLQGHTDVVISTACHP 311
Query: 288 RALALMPLIATSSHDCKVKIWNQD 311
+ A +D +K+W D
Sbjct: 312 TENIIAS--AALENDKTIKLWKSD 333
Score = 67.0 bits (162), Expect = 3e-11
Identities = 52/219 (23%), Positives = 95/219 (43%), Gaps = 10/219 (4%)
Query: 100 GHEHEITKVACIPKSSQFFSASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQ 159
GH ++ V P S+S D+++ +W + + + + GH + ++ +A S DS+
Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAY-DGKFEKTISGHKLGISDVAWSSDSNL 101
Query: 160 LCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSRGL 219
L + S D TL +WDV +G+ ++ N V + P+ I+ S D+++R+WD +
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG 161
Query: 220 QVAHMFPAKQHIQTYCEVSVDGHKCISCSNGFGGEGCEATLWDLRQTRNRICEYKGHFQT 279
+ PA + + DG +S S + G +WD +
Sbjct: 162 KCLKTLPAHSDPVSAVHFNRDGSLIVSSS--YDG---LCRIWDTASGQCLKTLIDDDNPP 216
Query: 280 VASCVFLPRALALMPLIATSSHDCKVKIWNQDTGACLFT 318
V+ F P I ++ D +K+W+ G CL T
Sbjct: 217 VSFVKFSPNG----KYILAATLDNTLKLWDYSKGKCLKT 251
Score = 61.2 bits (147), Expect = 1e-09
Identities = 49/218 (22%), Positives = 93/218 (42%), Gaps = 13/218 (5%)
Query: 141 LCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREP 200
L GH V+ + SP+ L + S D + +W G+ + S + ++ + W
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
Query: 201 YILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCISCSNGFGGEGCEATL 260
++ S+DKTL++WD + + C + + +S G +
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS-----GSFDESVRI 155
Query: 261 WDLRQTRNRICEYKGHFQTVASCVFLPRALALMPLIATSSHDCKVKIWNQDTGACLFTLS 320
WD++ T + H V++ F LI +SS+D +IW+ +G CL TL
Sbjct: 156 WDVK-TGKCLKTLPAHSDPVSAVHFNRDG----SLIVSSSYDGLCRIWDTASGQCLKTLI 210
Query: 321 LDGSGPLTSLAVG-DAISLLCASFNRGIHLLRMDHSQG 357
D + P++ + + +L A+ + + L D+S+G
Sbjct: 211 DDDNPPVSFVKFSPNGKYILAATLDNTLKL--WDYSKG 246
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 82.4 bits (202), Expect = 6e-16
Identities = 71/264 (26%), Positives = 121/264 (45%), Gaps = 14/264 (5%)
Query: 53 FQEYSPAHMDTVSVVA-ALNSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACI 111
F++ H +S VA + +S+L VS DKT+ ++ +G +K KGH + +
Sbjct: 79 FEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFN 138
Query: 112 PKSSQFFSASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLL 171
P+S+ S S D V +WD+ + + + L H+ V+ + + D S + + S D +
Sbjct: 139 PQSNLIVSGSFDESVRIWDVK-TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRI 197
Query: 172 WDVVTGQSVERASVSRN-VVTHLCWVPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQH 230
WD +GQ ++ N V+ + + P YIL + D TL+LWD + + ++
Sbjct: 198 WDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKN 257
Query: 231 IQTYC---EVSVDGHKCISCSNGFGGEGCEATLWDLRQTRNRICEYKGHFQTVASCVFLP 287
+ YC SV G K I G E +W+L QT+ + + +GH V S P
Sbjct: 258 -EKYCIFANFSVTGGKWIVS----GSEDNLVYIWNL-QTKEIVQKLQGHTDVVISTACHP 311
Query: 288 RALALMPLIATSSHDCKVKIWNQD 311
+ A +D +K+W D
Sbjct: 312 TENIIAS--AALENDKTIKLWKSD 333
Score = 67.0 bits (162), Expect = 3e-11
Identities = 52/219 (23%), Positives = 95/219 (43%), Gaps = 10/219 (4%)
Query: 100 GHEHEITKVACIPKSSQFFSASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQ 159
GH ++ V P S+S D+++ +W + + + + GH + ++ +A S DS+
Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAY-DGKFEKTISGHKLGISDVAWSSDSNL 101
Query: 160 LCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSRGL 219
L + S D TL +WDV +G+ ++ N V + P+ I+ S D+++R+WD +
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG 161
Query: 220 QVAHMFPAKQHIQTYCEVSVDGHKCISCSNGFGGEGCEATLWDLRQTRNRICEYKGHFQT 279
+ PA + + DG +S S + G +WD +
Sbjct: 162 KCLKTLPAHSDPVSAVHFNRDGSLIVSSS--YDG---LCRIWDTASGQCLKTLIDDDNPP 216
Query: 280 VASCVFLPRALALMPLIATSSHDCKVKIWNQDTGACLFT 318
V+ F P I ++ D +K+W+ G CL T
Sbjct: 217 VSFVKFSPNG----KYILAATLDNTLKLWDYSKGKCLKT 251
Score = 61.2 bits (147), Expect = 1e-09
Identities = 49/218 (22%), Positives = 93/218 (42%), Gaps = 13/218 (5%)
Query: 141 LCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREP 200
L GH V+ + SP+ L + S D + +W G+ + S + ++ + W
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
Query: 201 YILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCISCSNGFGGEGCEATL 260
++ S+DKTL++WD + + C + + +S G +
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS-----GSFDESVRI 155
Query: 261 WDLRQTRNRICEYKGHFQTVASCVFLPRALALMPLIATSSHDCKVKIWNQDTGACLFTLS 320
WD++ T + H V++ F LI +SS+D +IW+ +G CL TL
Sbjct: 156 WDVK-TGKCLKTLPAHSDPVSAVHFNRDG----SLIVSSSYDGLCRIWDTASGQCLKTLI 210
Query: 321 LDGSGPLTSLAVG-DAISLLCASFNRGIHLLRMDHSQG 357
D + P++ + + +L A+ + + L D+S+G
Sbjct: 211 DDDNPPVSFVKFSPNGKYILAATLDNTLKL--WDYSKG 246
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 78.2 bits (191), Expect = 1e-14
Identities = 71/258 (27%), Positives = 111/258 (43%), Gaps = 35/258 (13%)
Query: 99 KGHEHEITKVACIPK-SSQFFSASRDRMVMMWDLHGSSQ----PRQQLCGHAMVVTGLAV 153
KGH +T++A P+ SASRD+ ++MW L P++ L GH+ V+ + +
Sbjct: 12 KGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVI 71
Query: 154 SPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRL 213
S D +GS D TL LWD+ TG + R V + + I+ S DKT++L
Sbjct: 72 SSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKL 131
Query: 214 WDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCISCSNGFGGEGCEATLWD--LRQTRNRIC 271
W++ G+ K +Q E + C+ S + WD ++ C
Sbjct: 132 WNTLGV-------CKYTVQD--ESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182
Query: 272 EYK----GHFQTVASCVFLPRALALMPLIATSSHDCKVKIWNQDTGACLFTLSLDGSGPL 327
+ K GH + + P L A+ D + +W+ + G L+T LDG
Sbjct: 183 KLKTNHIGHTGYLNTVTVSPDG----SLCASGGKDGQAMLWDLNEGKHLYT--LDG---- 232
Query: 328 TSLAVGDAISLLCASFNR 345
GD I+ LC S NR
Sbjct: 233 -----GDIINALCFSPNR 245
Score = 69.7 bits (169), Expect = 4e-12
Identities = 56/211 (26%), Positives = 91/211 (43%), Gaps = 28/211 (13%)
Query: 73 DLCVSGGKDKTVVAYNWKT-------GNVVKRFKGHEHEITKVACIPKSSQFFSASRDRM 125
D+ +S +DKT++ WK G + +GH H ++ V S S D
Sbjct: 29 DMILSASRDKTIIM--WKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGT 86
Query: 126 VMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASV 185
+ +WDL + R + GH V +A S D+ Q+ +GSRD T+ LW+ + V + +V
Sbjct: 87 LRLWDLTTGTTTR-RFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTL---GVCKYTV 142
Query: 186 SRNVVTHLCWV--------PREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEV 237
+H WV P I+ DK +++W+ ++ V
Sbjct: 143 QDE--SHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTV 200
Query: 238 SVDGHKCISCSNGFGGEGCEATLWDLRQTRN 268
S DG C S GG+ +A LWDL + ++
Sbjct: 201 SPDGSLCAS-----GGKDGQAMLWDLNEGKH 226
Score = 63.2 bits (152), Expect = 4e-10
Identities = 45/162 (27%), Positives = 77/162 (47%), Gaps = 10/162 (6%)
Query: 62 DTVSVVAALNSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACI---PKSSQ-- 116
D +SV + ++ VSG +DKT+ W T V K E V+C+ P SS
Sbjct: 107 DVLSVAFSSDNRQIVSGSRDKTIKL--WNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPI 164
Query: 117 FFSASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVT 176
S D++V +W+L + + + GH + + VSPD S +G +D +LWD+
Sbjct: 165 IVSCGWDKLVKVWNL-ANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNE 223
Query: 177 GQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSRG 218
G+ + +++ LC+ P Y L + ++++WD G
Sbjct: 224 GKHLYTLD-GGDIINALCFSPNR-YWLCAATGPSIKIWDLEG 263
Score = 43.5 bits (101), Expect = 3e-04
Identities = 32/126 (25%), Positives = 55/126 (43%), Gaps = 12/126 (9%)
Query: 60 HMDTVSVVAALNSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFS 119
+++TV+V + + LC SGGKD + ++ G + G + I C + +
Sbjct: 194 YLNTVTV--SPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD--IINALCFSPNRYWLC 249
Query: 120 ASRDRMVMMWDLHGS---SQPRQQLCGHAMVV-----TGLAVSPDSSQLCTGSRDNTLLL 171
A+ + +WDL G + +Q++ + T LA S D L G DN + +
Sbjct: 250 AATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRV 309
Query: 172 WDVVTG 177
W V G
Sbjct: 310 WQVTIG 315
Score = 37.7 bits (86), Expect = 0.016
Identities = 37/153 (24%), Positives = 58/153 (37%), Gaps = 12/153 (7%)
Query: 71 NSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWD 130
++ + VS G DK V +N + GH + V P S S +D M+WD
Sbjct: 161 SNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD 220
Query: 131 LHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWD-----VVTGQSVERASV 185
L+ + L G ++ L SP+ LC + ++ +WD +V E S
Sbjct: 221 LN-EGKHLYTLDG-GDIINALCFSPNRYWLCAAT-GPSIKIWDLEGKIIVDELKQEVIST 277
Query: 186 SRNV----VTHLCWVPREPYILQTSEDKTLRLW 214
S T L W + D +R+W
Sbjct: 278 SSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVW 310
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 77.8 bits (190), Expect = 1e-14
Identities = 48/140 (34%), Positives = 65/140 (46%), Gaps = 1/140 (0%)
Query: 76 VSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWDLHGSS 135
V+G D+T+ ++ +G + GH + V +S FS D+ V WDL +
Sbjct: 220 VTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNK 279
Query: 136 QPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCW 195
R GH V GL + P L T SRD+T +WDV T SV S N V +
Sbjct: 280 VIRHYH-GHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRC 338
Query: 196 VPREPYILQTSEDKTLRLWD 215
EP I+ S D T+RLWD
Sbjct: 339 QAAEPQIITGSHDTTIRLWD 358
Score = 64.7 bits (156), Expect = 1e-10
Identities = 69/277 (24%), Positives = 106/277 (38%), Gaps = 18/277 (6%)
Query: 89 WKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWDLHGSSQPRQQLCGHAMVV 148
WK V+ GH + +A P + F + S DR + +WDL S + + L GH V
Sbjct: 194 WKLYRVIS---GHLGWVRCIAVEPGNQWFVTGSADRTIKIWDL-ASGKLKLSLTGHISTV 249
Query: 149 TGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSED 208
G+ VS S L + D + WD+ + + + V L P ++ S D
Sbjct: 250 RGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRD 309
Query: 209 KTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCISCSNGFGGEGCEATLWDLRQTRN 268
T R+WD R H + + I+ G LWDL +
Sbjct: 310 STARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIIT-----GSHDTTIRLWDLVAGKT 364
Query: 269 RICEYKGHFQTVASCVFLPRALALMPLIATSSHDCKVKIWNQDTGACLFTLSLDGSGPLT 328
R+ H ++V + V PR A+ S D +K W G+ + LS + +
Sbjct: 365 RV-TLTNHKKSVRAVVLHPRHYT----FASGSPD-NIKQWKFPDGSFIQNLS-GHNAIIN 417
Query: 329 SLAVGDAISLLCASFNRGIHLLRMDHSQGLELQEVAA 365
+L V L+ + N +HL D G Q V A
Sbjct: 418 TLTVNSDGVLVSGADNGTMHL--WDWRTGYNFQRVHA 452
Score = 61.2 bits (147), Expect = 1e-09
Identities = 50/210 (23%), Positives = 79/210 (37%), Gaps = 9/210 (4%)
Query: 60 HMDTV-SVVAALNSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFF 118
H+ TV V+ + S S G+DK V ++ + V++ + GH + + P
Sbjct: 245 HISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLV 304
Query: 119 SASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQ 178
+ SRD +WD+ + L GH V + Q+ TGS D T+ LWD+V G+
Sbjct: 305 TCSRDSTARIWDVRTKASV-HTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGK 363
Query: 179 SVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVS 238
+ + + V + PR Y + ++ W I V+
Sbjct: 364 TRVTLTNHKKSVRAVVLHPRH-YTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVN 422
Query: 239 VDGHKCISCSNGFGGEGCEATLWDLRQTRN 268
DG NG LWD R N
Sbjct: 423 SDGVLVSGADNG------TMHLWDWRTGYN 446
Score = 30.8 bits (68), Expect = 2.0
Identities = 20/94 (21%), Positives = 42/94 (44%), Gaps = 5/94 (5%)
Query: 32 KHSTYKYG-PDEIIEERIQTKAFQEYSPAHMDTVSVVAALNSDLCVSGGKDKTVVAYNWK 90
+H T+ G PD I + + +F + H ++ + + + VSG + T+ ++W+
Sbjct: 383 RHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLWDWR 442
Query: 91 TGNVVKRFKGHEHEITKVACIPKSSQFFSASRDR 124
TG +R H + + S F+ + D+
Sbjct: 443 TGYNFQRV----HAAVQPGSLDSESGIFACAFDQ 472
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 77.0 bits (188), Expect = 2e-14
Identities = 66/282 (23%), Positives = 117/282 (41%), Gaps = 34/282 (12%)
Query: 49 QTKAFQEYSPAHMDTVSVVAALNSD-LCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITK 107
+T F+ H D+V ++ +S L S D T+ ++++ ++ GH+H ++
Sbjct: 138 ETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSS 197
Query: 108 VACIPKSSQFFSASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDN 167
VA +P SASRD+ + MW++ + + GH V + + D + + + S D
Sbjct: 198 VAIMPNGDHIVSASRDKTIKMWEVQ-TGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQ 256
Query: 168 TLLLWDVVTGQSVERASVSRNVVTHLCWVPRE--------------------PYILQTSE 207
T+ +W V T + +VV + W P P++L S
Sbjct: 257 TVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSR 316
Query: 208 DKTLRLWD-SRGLQVAHMFPAKQHIQTYCEVSVDGHKCISCSNGFGGEGCEATLWDLRQT 266
DKT+++WD S G+ + + ++ S G +SC+ + +WD +
Sbjct: 317 DKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHS-GGKFILSCA-----DDKTLRVWDYKNK 370
Query: 267 RNRICEYKGHFQTVASCVFLPRALALMPLIATSSHDCKVKIW 308
R + H V S F A P + T S D VK+W
Sbjct: 371 R-CMKTLNAHEHFVTSLDFHKTA----PYVVTGSVDQTVKVW 407
Score = 73.9 bits (180), Expect = 2e-13
Identities = 57/244 (23%), Positives = 101/244 (41%), Gaps = 33/244 (13%)
Query: 76 VSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWDLHGSS 135
VS +D T+ ++++TG+ + KGH + ++ S S D + +WD G
Sbjct: 124 VSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFE 183
Query: 136 QPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCW 195
R + GH V+ +A+ P+ + + SRD T+ +W+V TG V+ + R V +
Sbjct: 184 CIR-TMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRP 242
Query: 196 VPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCISCSNGFGGEG 255
I S D+T+R+W + K+ C+ + H+ +
Sbjct: 243 NQDGTLIASCSNDQTVRVW---------VVATKE-----CKAELREHEHV---------- 278
Query: 256 CEATLWDLRQTRNRICEYKGHFQTVASCVFLPRALALMPLIATSSHDCKVKIWNQDTGAC 315
E W + + I E G ++ P + + S D +K+W+ TG C
Sbjct: 279 VECISWAPESSYSSISEATGS--------ETKKSGKPGPFLLSGSRDKTIKMWDVSTGMC 330
Query: 316 LFTL 319
L TL
Sbjct: 331 LMTL 334
Score = 58.9 bits (141), Expect = 7e-09
Identities = 53/221 (23%), Positives = 87/221 (39%), Gaps = 64/221 (28%)
Query: 60 HMDTVSVVAAL-NSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFF 118
H VS VA + N D VS +DKT+ + +TG VK F GH + V +
Sbjct: 191 HDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIA 250
Query: 119 SASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQ------------------- 159
S S D+ V +W + + + + +L H VV ++ +P+SS
Sbjct: 251 SCSNDQTVRVWVV-ATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGP 309
Query: 160 -LCTGSRDNTLLLWDVVTG----------------------------------------- 177
L +GSRD T+ +WDV TG
Sbjct: 310 FLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKN 369
Query: 178 -QSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSR 217
+ ++ + + VT L + PY++ S D+T+++W+ R
Sbjct: 370 KRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410
Score = 50.1 bits (118), Expect = 3e-06
Identities = 42/175 (24%), Positives = 70/175 (40%), Gaps = 10/175 (5%)
Query: 141 LCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREP 200
L GH VT + P S + + S D T+ +WD TG + V + +
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGK 163
Query: 201 YILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCISCSNGFGGEGCEATL 260
+ S D T++LWD +G + H + + +G +S S +
Sbjct: 164 LLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSAS-----RDKTIKM 218
Query: 261 WDLRQTRNRICEYKGHFQTVASCVFLPRALALMPLIATSSHDCKVKIWNQDTGAC 315
W++ QT + + GH + V + R LIA+ S+D V++W T C
Sbjct: 219 WEV-QTGYCVKTFTGHREWVR----MVRPNQDGTLIASCSNDQTVRVWVVATKEC 268
Score = 42.4 bits (98), Expect = 7e-04
Identities = 37/136 (27%), Positives = 56/136 (41%), Gaps = 14/136 (10%)
Query: 187 RNVVTHLCWVPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVD--GHKC 244
R+ VT + + P ++ SED T+++WD K H + ++S D G
Sbjct: 108 RSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTL--KGHTDSVQDISFDHSGKLL 165
Query: 245 ISCSNGFGGEGCEATLWDLRQTRNRICEYKGHFQTVASCVFLPRALALMPLIATSSHDCK 304
SCS LWD Q I GH V+S +P I ++S D
Sbjct: 166 ASCSADM-----TIKLWDF-QGFECIRTMHGHDHNVSSVAIMPNG----DHIVSASRDKT 215
Query: 305 VKIWNQDTGACLFTLS 320
+K+W TG C+ T +
Sbjct: 216 IKMWEVQTGYCVKTFT 231
>gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Homo
sapiens]
Length = 504
Score = 76.6 bits (187), Expect = 3e-14
Identities = 75/304 (24%), Positives = 127/304 (41%), Gaps = 24/304 (7%)
Query: 40 PDEIIEERIQTKAFQEYSPAHMDTVSVVAALNSDLCVS-------GGKDKTVVAYNWKTG 92
P+E+++ +K Q S + + S+ L DLC S GG DK VV ++ +
Sbjct: 195 PEELVKPEELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSE 254
Query: 93 NVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLA 152
++ KGH ++T V P FSAS D + +W + +S Q + H VTGL+
Sbjct: 255 QILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCV-QVVRAHESAVTGLS 313
Query: 153 VSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLC--WVPREPYILQTSEDKT 210
+ L + S D D+ TG+ + + + + + C + P + D
Sbjct: 314 LHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQ 373
Query: 211 LRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCISCSNGFGGEGCEATLWDLRQTRN-R 269
+++WD + FP T S +G+ + + + LWDLR+ +N +
Sbjct: 374 IKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAA-----DDSSVKLWDLRKLKNFK 428
Query: 270 ICEYKGHFQTVASCVFLPRALALMPLIATSSHDCKVKIWNQDTGACLFTLSLDGSGPLTS 329
+ +F+ V S +F L A D ++ I Q T FT + SG T
Sbjct: 429 TLQLDNNFE-VKSLIFDQSGTYL----ALGGTDVQIYICKQWTEILHFT---EHSGLTTG 480
Query: 330 LAVG 333
+A G
Sbjct: 481 VAFG 484
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 75.9 bits (185), Expect = 5e-14
Identities = 74/259 (28%), Positives = 102/259 (39%), Gaps = 26/259 (10%)
Query: 92 GNVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGL 151
G +K +GH + + SS S S D + WDL GS GHA V L
Sbjct: 332 GTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDL-GSFTNTVLYQGHAYPVWDL 390
Query: 152 AVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWV------PREPYILQT 205
+SP S +GS D T LW S +R R HL V P Y+
Sbjct: 391 DISPYSLYFASGSHDRTARLW------SFDRTYPLRIYAGHLADVDCVKFHPNSNYLATG 444
Query: 206 SEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCISCSNGFGGEGCEATLWDLRQ 265
S DKT+RLW ++ +F + S +G S GE LWDL
Sbjct: 445 STDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLAS-----AGEDQRLKLWDL-A 498
Query: 266 TRNRICEYKGHFQTVASCVFLPRALALMPLIATSSHDCKVKIWNQDTGACLFTLSLDG-S 324
+ E +GH + S F P + LIA++S D V++W+ C + DG S
Sbjct: 499 SGTLYKELRGHTDNITSLTFSPDS----GLIASASMDNSVRVWDIRNTYC--SAPADGSS 552
Query: 325 GPLTSLAVGDAISLLCASF 343
L + G ++L F
Sbjct: 553 SELVGVYTGQMSNVLSVQF 571
Score = 70.9 bits (172), Expect = 2e-12
Identities = 36/104 (34%), Positives = 56/104 (53%), Gaps = 1/104 (0%)
Query: 71 NSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWD 130
NS+ +G DKTV ++ + GN V+ F GH + +A P SA D+ + +WD
Sbjct: 437 NSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWD 496
Query: 131 LHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDV 174
L S ++L GH +T L SPDS + + S DN++ +WD+
Sbjct: 497 L-ASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDI 539
Score = 68.9 bits (167), Expect = 7e-12
Identities = 40/129 (31%), Positives = 58/129 (44%), Gaps = 3/129 (2%)
Query: 89 WKTGNVVKR--FKGHEHEITKVACIPKSSQFFSASRDRMVMMWDLHGSSQPRQQLCGHAM 146
W G+ ++GH + + + P S F S S DR +W + P + GH
Sbjct: 369 WDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFD-RTYPLRIYAGHLA 427
Query: 147 VVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQTS 206
V + P+S+ L TGS D T+ LW G SV + R V L + P Y+
Sbjct: 428 DVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAG 487
Query: 207 EDKTLRLWD 215
ED+ L+LWD
Sbjct: 488 EDQRLKLWD 496
Score = 66.6 bits (161), Expect = 3e-11
Identities = 43/165 (26%), Positives = 68/165 (41%), Gaps = 15/165 (9%)
Query: 77 SGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWDLHGSSQ 136
SG D+T +++ ++ + GH ++ V P S+ + S D+ V +W +
Sbjct: 401 SGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNS 460
Query: 137 PRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWV 196
R GH V LA SP+ L + D L LWD+ +G + + +T L +
Sbjct: 461 VRL-FTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFS 519
Query: 197 PREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDG 241
P I S D ++R+WD R TYC DG
Sbjct: 520 PDSGLIASASMDNSVRVWDIR--------------NTYCSAPADG 550
Score = 42.4 bits (98), Expect = 7e-04
Identities = 20/71 (28%), Positives = 35/71 (49%)
Query: 64 VSVVAALNSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRD 123
+S+ + N S G+D+ + ++ +G + K +GH IT + P S SAS D
Sbjct: 472 LSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMD 531
Query: 124 RMVMMWDLHGS 134
V +WD+ +
Sbjct: 532 NSVRVWDIRNT 542
Score = 31.6 bits (70), Expect = 1.2
Identities = 45/211 (21%), Positives = 75/211 (35%), Gaps = 43/211 (20%)
Query: 153 VSPDSSQLCTGSRDNTLLLW-----------------------DVVTGQSVE--RASVSR 187
+SPDS L G ++ + LW D++ + E A
Sbjct: 276 ISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDNAGTEM 335
Query: 188 NVVTHLC-------WVPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVD 240
++ C ++ +L SED ++R WD ++ + H ++ +
Sbjct: 336 KILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLY--QGHAYPVWDLDIS 393
Query: 241 GHKCISCSNGFGGEGCEATLWDLRQTRNRICEYKGHFQTVASCVFLPRALALMPLIATSS 300
+ S G A LW +T + Y GH V F P + +AT S
Sbjct: 394 PYSLYFAS---GSHDRTARLWSFDRT-YPLRIYAGHLADVDCVKFHPNS----NYLATGS 445
Query: 301 HDCKVKIWNQDTGACLFTLSLDGSGPLTSLA 331
D V++W+ G + L GP+ SLA
Sbjct: 446 TDKTVRLWSAQQGNSV-RLFTGHRGPVLSLA 475
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 75.5 bits (184), Expect = 7e-14
Identities = 59/211 (27%), Positives = 95/211 (45%), Gaps = 12/211 (5%)
Query: 100 GHEHEITKVACIPKSSQFFSASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQ 159
GHE E+ P S SA DR++++W+++G L GH+ V L + D S
Sbjct: 64 GHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSM 123
Query: 160 LCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQT-SEDKTLRLWDSRG 218
L + S D T+ +WD TG+ V+R + V R P ++ T S+D T++LWD R
Sbjct: 124 LFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRK 183
Query: 219 LQVAHMFPAKQHIQTYCEVSVDGHKCISCSNGFGGEGCEATLWDLRQTRNRICEYKGHFQ 278
F TY ++V + S GG + +WDLRQ + +GH
Sbjct: 184 KAAIQTFQ-----NTYQVLAVTFND-TSDQIISGGIDNDIKVWDLRQNK-LTYTMRGHAD 236
Query: 279 TVASCVFLPRALALMPLIATSSHDCKVKIWN 309
+V L+ +++ D V++W+
Sbjct: 237 SVTGLSLSSEGSYLL----SNAMDNTVRVWD 263
Score = 61.2 bits (147), Expect = 1e-09
Identities = 58/241 (24%), Positives = 95/241 (39%), Gaps = 21/241 (8%)
Query: 71 NSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFF-SASRDRMVMMW 129
+ + S DKTV ++ +TG VKR KGH + + Q + S D V +W
Sbjct: 120 DGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLW 179
Query: 130 DLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNV 189
D+ + Q + V + + S Q+ +G DN + +WD+ + +
Sbjct: 180 DIR--KKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADS 237
Query: 190 VTHLCWVPREPYILQTSEDKTLRLWDSRGL----QVAHMFPAKQH----IQTYCEVSVDG 241
VT L Y+L + D T+R+WD R + +F H C S DG
Sbjct: 238 VTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDG 297
Query: 242 HKCISCSNGFGGEGCEATLWDLRQTRNRICEYKGHFQTVASCVFLPRALALMPLIATSSH 301
K + G +WD +R + + GH ++ F P P+I ++S
Sbjct: 298 SKIAA-----GSADRFVYVWD-TTSRRILYKLPGHAGSINEVAFHPDE----PIIISASS 347
Query: 302 D 302
D
Sbjct: 348 D 348
Score = 55.5 bits (132), Expect = 8e-08
Identities = 32/147 (21%), Positives = 63/147 (42%), Gaps = 7/147 (4%)
Query: 72 SDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWDL 131
SD +SGG D + ++ + + +GH +T ++ + S S + D V +WD+
Sbjct: 205 SDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDV 264
Query: 132 HGSSQPRQ-------QLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERAS 184
+ + + + + SPD S++ GS D + +WD + + + +
Sbjct: 265 RPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLP 324
Query: 185 VSRNVVTHLCWVPREPYILQTSEDKTL 211
+ + + P EP I+ S DK L
Sbjct: 325 GHAGSINEVAFHPDEPIIISASSDKRL 351
Score = 54.7 bits (130), Expect = 1e-07
Identities = 46/196 (23%), Positives = 82/196 (41%), Gaps = 9/196 (4%)
Query: 71 NSDLCVSGGKDKTVVAYN-WKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMW 129
N S G D+ ++ +N + + KGH + ++ S FSAS D+ V +W
Sbjct: 77 NGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVW 136
Query: 130 DLHGSSQPRQQLCGHAMVVTGLAVSPDSSQL-CTGSRDNTLLLWDVVTGQSVERASVSRN 188
D + + ++L GH V + QL CTGS D T+ LWD+ +++ +
Sbjct: 137 DSE-TGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQ 195
Query: 189 VVTHLCWVPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCISCS 248
V+ + + I+ D +++WD R Q + + H + +S+ S
Sbjct: 196 VLA-VTFNDTSDQIISGGIDNDIKVWDLR--QNKLTYTMRGHADSVTGLSLSSEGSYLLS 252
Query: 249 NGFGGEGCEATLWDLR 264
N +WD+R
Sbjct: 253 NAMDN---TVRVWDVR 265
Score = 38.1 bits (87), Expect = 0.013
Identities = 32/124 (25%), Positives = 56/124 (45%), Gaps = 10/124 (8%)
Query: 60 HMDTVSVVA-ALNSDLCVSGGKDKTVVAYNWKT----GNVVKRFKGHEHEITK----VAC 110
H D+V+ ++ + +S D TV ++ + VK F+G+ H K +
Sbjct: 234 HADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSW 293
Query: 111 IPKSSQFFSASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLL 170
P S+ + S DR V +WD S + +L GHA + +A PD + + S D L
Sbjct: 294 SPDGSKIAAGSADRFVYVWDTT-SRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLY 352
Query: 171 LWDV 174
+ ++
Sbjct: 353 MGEI 356
Score = 36.2 bits (82), Expect = 0.048
Identities = 40/158 (25%), Positives = 62/158 (39%), Gaps = 30/158 (18%)
Query: 137 PRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVS--RNVVTHLC 194
P L GH V P+ S L + D +LLW+V G A++ V L
Sbjct: 58 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY-GDCDNYATLKGHSGAVMELH 116
Query: 195 WVPREPYILQTSEDKTLRLWDSR-GLQVAHM----------FPAKQHIQTYCEVSVDGHK 243
+ + S DKT+ +WDS G +V + +PA++ Q C S DG
Sbjct: 117 YNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDG-- 174
Query: 244 CISCSNGFGGEGCEATLWDLRQTRNRICEYKGHFQTVA 281
LWD+R+ + I ++ +Q +A
Sbjct: 175 -------------TVKLWDIRK-KAAIQTFQNTYQVLA 198
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 75.1 bits (183), Expect = 9e-14
Identities = 69/259 (26%), Positives = 107/259 (41%), Gaps = 28/259 (10%)
Query: 81 DKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMW--DLHGSSQPR 138
D ++ ++ K + RF GH+ +T V P S SRD+ V +W ++ G S
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
Query: 139 QQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWV-- 196
+ H V + D T S D T+ +W + R ++ H+ WV
Sbjct: 62 R---AHTATVRSVHFCSDGQSFVTASDDKTVKVW------ATHRQKFLFSLSQHINWVRC 112
Query: 197 ----PREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCISCSNGFG 252
P I+ S+DKT++LWD + H + TY VD H +C G
Sbjct: 113 AKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTY----VDFHPSGTCIAAAG 168
Query: 253 GEGCEATLWDLRQTRNRICEYKGHFQTVASCVFLPRALALMPLIATSSHDCKVKIWNQDT 312
+ +WD+R T + Y+ H V F P L+ T+S D +KI +
Sbjct: 169 MDN-TVKVWDVR-THRLLQHYQLHSAAVNGLSFHPSGNYLI----TASSDSTLKILDLME 222
Query: 313 GACLFTLSLDGSGPLTSLA 331
G L+TL GP T++A
Sbjct: 223 GRLLYTLH-GHQGPATTVA 240
Score = 57.4 bits (137), Expect = 2e-08
Identities = 48/161 (29%), Positives = 68/161 (42%), Gaps = 8/161 (4%)
Query: 59 AHMDTV-SVVAALNSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACI---PKS 114
AH TV SV + V+ DKTV W T F +H I V C P
Sbjct: 63 AHTATVRSVHFCSDGQSFVTASDDKTVKV--WATHRQKFLFSLSQH-INWVRCAKFSPDG 119
Query: 115 SQFFSASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDV 174
SAS D+ V +WD S + C H VT + P + + DNT+ +WDV
Sbjct: 120 RLIVSASDDKTVKLWD-KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 178
Query: 175 VTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWD 215
T + ++ + V L + P Y++ S D TL++ D
Sbjct: 179 RTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILD 219
Score = 55.8 bits (133), Expect = 6e-08
Identities = 45/163 (27%), Positives = 67/163 (41%), Gaps = 10/163 (6%)
Query: 60 HMDTVSVVA-ALNSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFF 118
H D V+ V + + L SG +DKTV + F+ H + V F
Sbjct: 22 HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFV 81
Query: 119 SASRDRMVMMWDLHGSSQPRQQ----LCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDV 174
+AS D+ V +W H RQ+ L H V SPD + + S D T+ LWD
Sbjct: 82 TASDDKTVKVWATH-----RQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDK 136
Query: 175 VTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSR 217
+ + V VT++ + P I D T+++WD R
Sbjct: 137 SSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 179
Score = 51.6 bits (122), Expect = 1e-06
Identities = 36/143 (25%), Positives = 62/143 (43%), Gaps = 1/143 (0%)
Query: 74 LCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWDLHG 133
L VS DKTV ++ + V + H +T V P + +A D V +WD+
Sbjct: 121 LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR- 179
Query: 134 SSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHL 193
+ + Q H+ V GL+ P + L T S D+TL + D++ G+ + + T +
Sbjct: 180 THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV 239
Query: 194 CWVPREPYILQTSEDKTLRLWDS 216
+ Y D+ + +W S
Sbjct: 240 AFSRTGEYFASGGSDEQVMVWKS 262
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 75.1 bits (183), Expect = 9e-14
Identities = 65/324 (20%), Positives = 120/324 (37%), Gaps = 47/324 (14%)
Query: 38 YGPDEIIEERIQTKAFQEYSPAHMDTVSVVAALNSDLCVSGGKDKTVVAYNWKTGNVVKR 97
Y P I R T+ +SV + SG D TV ++ T
Sbjct: 92 YQPQAIFRVRAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFT 151
Query: 98 FKGHEHEITKVACIPKSSQFFSASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLA----- 152
KGH H + ++ P + S ++ +++WD Q + L GH+ +TGL+
Sbjct: 152 CKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLH 211
Query: 153 VSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLR 212
+P+ + + S+D ++ +WD G+ + VT L W + + S+D+T++
Sbjct: 212 ANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRW-GGDGLLYSASQDRTIK 270
Query: 213 LWDSRGLQVAHMFPAKQHIQTYCEVSVD---------------------------GHKCI 245
+W + + H +S D + +
Sbjct: 271 VWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERAL 330
Query: 246 SCSNGFGGEGCEAT----------LWDLRQTRNRICEYKGHFQTVASCVFLPRALALMPL 295
S N G+G E LW + + + GH + +F P + +
Sbjct: 331 SRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDS----RI 386
Query: 296 IATSSHDCKVKIWNQDTGACLFTL 319
+A++S D +K+W+ TG L +L
Sbjct: 387 VASASFDKSIKLWDGRTGKYLASL 410
Score = 62.4 bits (150), Expect = 6e-10
Identities = 48/166 (28%), Positives = 72/166 (43%), Gaps = 6/166 (3%)
Query: 52 AFQEYSPAHMDTVSVVAALNSDLCVSGGKDKTVVAYNWKTGNVVK---RFKGHEHEITKV 108
+ QE + ++V + VSG D T+ + W K R GH+ I +V
Sbjct: 321 SLQELKERALSRYNLVRGQGPERLVSGSDDFTL--FLWSPAEDKKPLTRMTGHQALINQV 378
Query: 109 ACIPKSSQFFSASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNT 168
P S SAS D+ + +WD + + L GH V +A S DS L +GS D+T
Sbjct: 379 LFSPDSRIVASASFDKSIKLWD-GRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDST 437
Query: 169 LLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLW 214
L +WDV + + V + W P + +DK LR+W
Sbjct: 438 LKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 55.5 bits (132), Expect = 8e-08
Identities = 32/128 (25%), Positives = 56/128 (43%)
Query: 119 SASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQ 178
S S D + +W +P ++ GH ++ + SPDS + + S D ++ LWD TG+
Sbjct: 346 SGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGK 405
Query: 179 SVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVS 238
+ V + W ++ S D TL++WD + ++A P + S
Sbjct: 406 YLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWS 465
Query: 239 VDGHKCIS 246
DG + S
Sbjct: 466 PDGQRVAS 473
Score = 42.7 bits (99), Expect = 5e-04
Identities = 48/186 (25%), Positives = 72/186 (38%), Gaps = 15/186 (8%)
Query: 143 GHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYI 202
GH+ V +A SP L +GS D T+ WD+ T R+ V + W P +
Sbjct: 112 GHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKL 171
Query: 203 LQTSEDKTLRLWD-SRGLQVAHMFPAKQHIQTYCEVSVDG-HKCISCSN-GFGGEGCEAT 259
++ + LWD S G QV H + +S + H C +
Sbjct: 172 ASGCKNGQILLWDPSTGKQVGRTLAG--HSKWITGLSWEPLHANPECRYVASSSKDGSVR 229
Query: 260 LWDLRQTRNRICE--YKGHFQTVASCVFLPRALALMPLIATSSHDCKVKIWNQDTGACLF 317
+WD R CE GH Q+V +C+ L+ ++S D +K+W G
Sbjct: 230 IWDTTAGR---CERILTGHTQSV-TCL----RWGGDGLLYSASQDRTIKVWRAHDGVLCR 281
Query: 318 TLSLDG 323
TL G
Sbjct: 282 TLQGHG 287
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 74.3 bits (181), Expect = 2e-13
Identities = 66/255 (25%), Positives = 115/255 (45%), Gaps = 10/255 (3%)
Query: 60 HMDTVSVVA-ALNSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFF 118
H + VS V + N + S D+ ++ + G K GH EI+ VA SS+
Sbjct: 40 HTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLV 99
Query: 119 SASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQ 178
SAS D+ + +WD+ S + + L GH+ V +P S+ + +GS D T+ +W+V TG+
Sbjct: 100 SASDDKTLKLWDVR-SGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGK 158
Query: 179 SVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWD-SRGLQVAHMFPAKQHIQTYCEV 237
++ S + V+ + + I+ S D R+WD + G + + ++ +
Sbjct: 159 CLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKF 218
Query: 238 SVDGHKCISCSNGFGGEGCEATLWDLRQTRNRICEYKGHFQTVASCVFLPRALALMPLIA 297
S +G ++ + LWD + R + Y GH + C+F ++ I
Sbjct: 219 SPNGKYILTAT-----LDNTLKLWDYSRGR-CLKTYTGH-KNEKYCIFANFSVTGGKWIV 271
Query: 298 TSSHDCKVKIWNQDT 312
+ S D V IWN T
Sbjct: 272 SGSEDNLVYIWNLQT 286
Score = 68.2 bits (165), Expect = 1e-11
Identities = 53/219 (24%), Positives = 92/219 (42%), Gaps = 10/219 (4%)
Query: 100 GHEHEITKVACIPKSSQFFSASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQ 159
GH ++ V P S+S DR++++W + + L GH + ++ +A S DSS+
Sbjct: 39 GHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKT-LYGHNLEISDVAWSSDSSR 97
Query: 160 LCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSRGL 219
L + S D TL LWDV +G+ ++ N V + P I+ S D+T+++W+ +
Sbjct: 98 LVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTG 157
Query: 220 QVAHMFPAKQHIQTYCEVSVDGHKCISCSNGFGGEGCEATLWDLRQTRNRICEYKGHFQT 279
+ A + + G +S G +WD +
Sbjct: 158 KCLKTLSAHSDPVSAVHFNCSGSLIVS-----GSYDGLCRIWDAASGQCLKTLVDDDNPP 212
Query: 280 VASCVFLPRALALMPLIATSSHDCKVKIWNQDTGACLFT 318
V+ F P I T++ D +K+W+ G CL T
Sbjct: 213 VSFVKFSPNG----KYILTATLDNTLKLWDYSRGRCLKT 247
Score = 59.7 bits (143), Expect = 4e-09
Identities = 45/189 (23%), Positives = 81/189 (42%), Gaps = 12/189 (6%)
Query: 141 LCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNV-VTHLCWVPRE 199
L GH V+ + SP+ L + S D +++W G+ E+ N+ ++ + W
Sbjct: 37 LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGK-YEKTLYGHNLEISDVAWSSDS 95
Query: 200 PYILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCISCSNGFGGEGCEAT 259
++ S+DKTL+LWD R + + C + + IS G
Sbjct: 96 SRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIIS-----GSFDETVK 150
Query: 260 LWDLRQTRNRICEYKGHFQTVASCVFLPRALALMPLIATSSHDCKVKIWNQDTGACLFTL 319
+W+++ T + H V++ F LI + S+D +IW+ +G CL TL
Sbjct: 151 IWEVK-TGKCLKTLSAHSDPVSAVHFNCSG----SLIVSGSYDGLCRIWDAASGQCLKTL 205
Query: 320 SLDGSGPLT 328
D + P++
Sbjct: 206 VDDDNPPVS 214
Score = 45.1 bits (105), Expect = 1e-04
Identities = 40/166 (24%), Positives = 72/166 (43%), Gaps = 10/166 (6%)
Query: 59 AHMDTVSVVAA-LNSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHE-ITKVACIPKSSQ 116
AH D VS V + L VSG D ++ +G +K ++ ++ V P
Sbjct: 165 AHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKY 224
Query: 117 FFSASRDRMVMMWDLHGSSQPRQQLCGHA----MVVTGLAVSPDSSQLCTGSRDNTLLLW 172
+A+ D + +WD + + + GH + +V+ + +GS DN + +W
Sbjct: 225 ILTATLDNTLKLWD-YSRGRCLKTYTGHKNEKYCIFANFSVT-GGKWIVSGSEDNLVYIW 282
Query: 173 DVVTGQSVERASVSRNVVTHLCWVPREPYILQTS--EDKTLRLWDS 216
++ T + V++ +VV P E I + DKT++LW S
Sbjct: 283 NLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLWMS 328
>gi|55743108 ATG16 autophagy related 16-like 2 [Homo sapiens]
Length = 619
Score = 73.2 bits (178), Expect = 4e-13
Identities = 79/277 (28%), Positives = 121/277 (43%), Gaps = 23/277 (8%)
Query: 44 IEERIQTKAFQEYSPAHMDTVSVVA-ALNSDLCVSGGKDKTVVAYNWKTGNVV--KRFKG 100
+ R+ T+A Q+ AH+ V+ V NS L +GG D+ + +N + + +G
Sbjct: 320 VAARLPTRA-QDVLDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEG 378
Query: 101 HEHEITKVACIPKSSQFFSASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQL 160
IT V P Q +A+ ++ +W + G +Q ++ L GH VT Q
Sbjct: 379 AGGSITSVDFDPSGYQVLAATYNQAAQLWKV-GEAQSKETLSGHKDKVTAAKFKLTRHQA 437
Query: 161 CTGSRDNTLLLWDVVTGQSVERASVSRNV-VTHLC--WVPREPYILQTSEDKTLRLWDSR 217
TGSRD T+ WD + RA SR + V C V + I+ D+ +R WDSR
Sbjct: 438 VTGSRDRTVKEWD------LGRAYCSRTINVLSYCNDVVCGDHIIISGHNDQKIRFWDSR 491
Query: 218 GLQVAHMFPAKQHIQTYCEVSVDGHKCISCSNGFGGEGCEATLWDLRQTRNRICEYKGHF 277
G + P + + T +S D +SCS + + + ++RQ G
Sbjct: 492 GPHCTQVIPVQGRV-TSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRADGFKCGSD 550
Query: 278 QTVASCVFLP-RALALMPLIATSSHDCKVKIWNQDTG 313
T A VF P R+ AL S D + IW+ DTG
Sbjct: 551 WTKA--VFSPDRSYAL-----AGSCDGALYIWDVDTG 580
Score = 38.9 bits (89), Expect = 0.007
Identities = 50/244 (20%), Positives = 84/244 (34%), Gaps = 59/244 (24%)
Query: 101 HEHEITKVACIPKSSQFFSASRDRMVMMWDLHGSS-QPRQQLCGHAMVVTGLAVSPDSSQ 159
H E+ V P SS + DR++ +W++ GS + Q L G +T + P Q
Sbjct: 335 HLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQ 394
Query: 160 LCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSRGL 219
+ + + LW V QS E S ++ VT + + S D+T++ WD
Sbjct: 395 VLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWD---- 450
Query: 220 QVAHMFPAKQHIQTYCEVSVDGHKCISCSNGFGGEGCEATLWDLRQTRNRICEYKGHFQT 279
G C T+ L + +C
Sbjct: 451 -------------------------------LGRAYCSRTINVLSYCNDVVCGDH----- 474
Query: 280 VASCVFLPRALALMPLIATSSHDCKVKIWNQDTGACLFTLSLDGSGPLTSLAVG-DAISL 338
+I + +D K++ W+ C T + G +TSL++ D + L
Sbjct: 475 ---------------IIISGHNDQKIRFWDSRGPHC--TQVIPVQGRVTSLSLSHDQLHL 517
Query: 339 LCAS 342
L S
Sbjct: 518 LSCS 521
Score = 36.2 bits (82), Expect = 0.048
Identities = 39/164 (23%), Positives = 67/164 (40%), Gaps = 16/164 (9%)
Query: 63 TVSVVAALNSDLC-----VSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQF 117
T++V++ N +C +SG D+ + ++ + G + + +T ++
Sbjct: 459 TINVLSYCNDVVCGDHIIISGHNDQKIRFWDSR-GPHCTQVIPVQGRVTSLSLSHDQLHL 517
Query: 118 FSASRDRMVMMWDLHGSSQPRQQL------CGHAMVVTGLAVSPDSSQLCTGSRDNTLLL 171
S SRD + + DL S+ RQ CG T SPD S GS D L +
Sbjct: 518 LSCSRDNTLKVIDLRVSNI-RQVFRADGFKCGSDW--TKAVFSPDRSYALAGSCDGALYI 574
Query: 172 WDVVTGQSVERASVSR-NVVTHLCWVPREPYILQTSEDKTLRLW 214
WDV TG+ R V + W +++ + + + LW
Sbjct: 575 WDVDTGKLESRLQGPHCAAVNAVAWCYSGSHMVSVDQGRKVVLW 618
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 72.4 bits (176), Expect = 6e-13
Identities = 60/228 (26%), Positives = 94/228 (41%), Gaps = 15/228 (6%)
Query: 41 DEIIEERIQTKAFQEYSPAHMDTVSVVAALNS---DLCVSGGKDKTVVAYNWKTGNVVKR 97
D+++E + K E + + V A S + +S +D TV ++ +T +
Sbjct: 521 DDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVG 580
Query: 98 FKGHEHEITKVACIPKSSQFFSASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDS 157
+KGH + + P F S DR+ +W QP + GH V P+S
Sbjct: 581 YKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATD-HYQPLRIFAGHLADVNCTRFHPNS 639
Query: 158 SQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWD-S 216
+ + TGS D T+ LWDV+ G V + + + L + P ++ + D + LWD
Sbjct: 640 NYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIG 699
Query: 217 RGLQVAHMFPAKQHIQTYCEV--SVDGHKCISCSNGFGGEGCEATLWD 262
GL V + K H T C + S DG S G LWD
Sbjct: 700 HGLMVGEL---KGHTDTVCSLRFSRDGEILAS-----GSMDNTVRLWD 739
Score = 63.5 bits (153), Expect = 3e-10
Identities = 45/143 (31%), Positives = 66/143 (46%), Gaps = 5/143 (3%)
Query: 76 VSGGKDKTVVAYNWKTGNV--VKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWDLHG 133
VSGG D+ VA W T + ++ F GH ++ P S+ + S DR V +WD+
Sbjct: 601 VSGGHDR--VARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLN 658
Query: 134 SSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHL 193
+ R GH + L SP+ L TG+ D +LLWD+ G V + V L
Sbjct: 659 GNCVRI-FTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSL 717
Query: 194 CWVPREPYILQTSEDKTLRLWDS 216
+ + S D T+RLWD+
Sbjct: 718 RFSRDGEILASGSMDNTVRLWDA 740
Score = 62.4 bits (150), Expect = 6e-10
Identities = 35/105 (33%), Positives = 52/105 (49%), Gaps = 1/105 (0%)
Query: 71 NSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWD 130
NS+ +G D+TV ++ GN V+ F GH+ I + P + + D V++WD
Sbjct: 638 NSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWD 697
Query: 131 LHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVV 175
+ G +L GH V L S D L +GS DNT+ LWD +
Sbjct: 698 I-GHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAI 741
Score = 40.8 bits (94), Expect = 0.002
Identities = 58/247 (23%), Positives = 95/247 (38%), Gaps = 43/247 (17%)
Query: 148 VTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQ--SVERAS-------VSRNVVTHLC---- 194
+T + V+ DSS + G D+T+ +W V + SV++AS S +V+ +
Sbjct: 473 LTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKT 532
Query: 195 ------------------WVPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCE 236
+ P Y+L +SED T+RLW + + + +
Sbjct: 533 ASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQ 592
Query: 237 VSVDGHKCISCSNGFGGEGCEATLWDLRQTRNRICEYKGHFQTVASCVFLPRALALMPLI 296
S G+ +S GG A LW + + + GH V F P + +
Sbjct: 593 FSPYGYYFVS-----GGHDRVARLWATDHYQP-LRIFAGHLADVNCTRFHPNS----NYV 642
Query: 297 ATSSHDCKVKIWNQDTGACLFTLSLDGSGPLTSLAVGDAISLLCASFNRGIHLLRMDHSQ 356
AT S D V++W+ G C+ + GP+ SL L G +L D
Sbjct: 643 ATGSADRTVRLWDVLNGNCV-RIFTGHKGPIHSLTFSPNGRFLATGATDG-RVLLWDIGH 700
Query: 357 GLELQEV 363
GL + E+
Sbjct: 701 GLMVGEL 707
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 72.0 bits (175), Expect = 8e-13
Identities = 71/287 (24%), Positives = 119/287 (41%), Gaps = 29/287 (10%)
Query: 54 QEYSPAHMDTV-SVVAALNSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIP 112
+ Y H + S+ + N + D ++ +N+K R+ GH+ +T V P
Sbjct: 11 ERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP 70
Query: 113 KSSQFFSASRDRMVMMW--DLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLL 170
+ SASRDR V +W D G + H V + S D L T S D ++
Sbjct: 71 HGNLLASASRDRTVRLWIPDKRGKF---SEFKAHTAPVRSVDFSADGQFLATASEDKSIK 127
Query: 171 LWDVVTGQSVERASVSRNVVTHLCWV------PREPYILQTSEDKTLRLWDSRGLQVAHM 224
+W S+ R ++ H WV P I+ SEDKT+++WD+ Q +
Sbjct: 128 VW------SMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN 181
Query: 225 FPAKQHIQTYCEVSVDGHKCISCSNGFGGEGCEATLWDLRQTRNRICEYKGHFQTVASCV 284
F + + + G CI+ + G +WD+R + Y+ H V
Sbjct: 182 FSDSVGFANFVDFNPSG-TCIASA----GSDQTVKVWDVR-VNKLLQHYQVHSGGVNCIS 235
Query: 285 FLPRALALMPLIATSSHDCKVKIWNQDTGACLFTLSLDGSGPLTSLA 331
F P L+ T+S D +KI + G ++TL +GP+ +++
Sbjct: 236 FHPSGNYLI----TASSDGTLKILDLLEGRLIYTLQ-GHTGPVFTVS 277
Score = 43.5 bits (101), Expect = 3e-04
Identities = 30/163 (18%), Positives = 61/163 (37%), Gaps = 1/163 (0%)
Query: 53 FQEYSPAHMDTVSVVAALNSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIP 112
F E+ SV + + + +DK++ ++ + H H + P
Sbjct: 95 FSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSP 154
Query: 113 KSSQFFSASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLW 172
S S D+ + +WD + Q + +P + + + D T+ +W
Sbjct: 155 DGRLIVSCSEDKTIKIWDT-TNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVW 213
Query: 173 DVVTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWD 215
DV + ++ V V + + P Y++ S D TL++ D
Sbjct: 214 DVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILD 256
Score = 36.2 bits (82), Expect = 0.048
Identities = 24/102 (23%), Positives = 46/102 (45%), Gaps = 2/102 (1%)
Query: 72 SDLCV-SGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWD 130
S C+ S G D+TV ++ + +++ ++ H + ++ P + +AS D + + D
Sbjct: 197 SGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILD 256
Query: 131 LHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLW 172
L + L GH V ++ S +G D +LLW
Sbjct: 257 LL-EGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297
>gi|4505731 peroxisomal biogenesis factor 7 [Homo sapiens]
Length = 323
Score = 70.9 bits (172), Expect = 2e-12
Identities = 52/194 (26%), Positives = 81/194 (41%), Gaps = 10/194 (5%)
Query: 119 SASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQ--LCTGSRDNTLLLWDVVT 176
+ S D + +WD ++ P Q HA V + S + + +GS D T+ LWD
Sbjct: 85 TCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDPTV 144
Query: 177 GQSVERASVSRNVVTHLCWVPREP-YILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYC 235
G+S+ +++ W P P S D+TLR+WD + V + PA Q C
Sbjct: 145 GKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVRIVIPAHQAEILSC 204
Query: 236 EVSVDGHKCISCSNGFGGEGCEATLWDLRQTRNRICEYKGHFQTVASCVFLPRALALMPL 295
+ + G C WDLR R + E GH + F P + +
Sbjct: 205 DWCKYNENLLVT----GAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHAS---V 257
Query: 296 IATSSHDCKVKIWN 309
+A+ S+D V+ WN
Sbjct: 258 LASCSYDFTVRFWN 271
Score = 37.0 bits (84), Expect = 0.028
Identities = 38/145 (26%), Positives = 63/145 (43%), Gaps = 3/145 (2%)
Query: 74 LCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPK-SSQFFSASRDRMVMMWDLH 132
L VSG D+TV ++ G + F+GHE I P F SAS D+ + +WD+
Sbjct: 127 LVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVK 186
Query: 133 GSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDV-VTGQSVERASVSRNVVT 191
+ A +++ + + L TG+ D +L WD+ Q V +
Sbjct: 187 AAGVRIVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIR 246
Query: 192 HLCWVPREPYILQT-SEDKTLRLWD 215
+ + P +L + S D T+R W+
Sbjct: 247 RVKFSPFHASVLASCSYDFTVRFWN 271
Score = 30.0 bits (66), Expect = 3.4
Identities = 28/104 (26%), Positives = 41/104 (39%), Gaps = 7/104 (6%)
Query: 215 DSRGLQVAHMFPAKQHIQTYCEVSVDGHKCISCSNGFGGEGCEATLWDLRQTRNRICEYK 274
D GL++ F + + H I+CS G+G LWD + + YK
Sbjct: 54 DEAGLRLFRSFDWNDGLFDVTWSENNEHVLITCS----GDG-SLQLWDTAKAAGPLQVYK 108
Query: 275 GHFQTVASCVFLPRALALMPLIATSSHDCKVKIWNQDTGACLFT 318
H Q V S + L+ + S D VK+W+ G L T
Sbjct: 109 EHAQEVYSVDWSQTRGE--QLVVSGSWDQTVKLWDPTVGKSLCT 150
>gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)
[Homo sapiens]
Length = 906
Score = 67.4 bits (163), Expect = 2e-11
Identities = 48/163 (29%), Positives = 77/163 (47%), Gaps = 6/163 (3%)
Query: 59 AHMDTVSVVAALNSD-LCVSGGKDKTVVAYNW-KTGNVVKRFKGHEHEITKVACIPK-SS 115
AH D + +A + ++ D + ++W K + + F+GH H + ++ PK ++
Sbjct: 97 AHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNN 156
Query: 116 QFFSASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAV--SPDSSQLCTGSRDNTLLLWD 173
QF SAS DR + +W L GSS P L GH V + D L +G+ D + +WD
Sbjct: 157 QFASASLDRTIKVWQL-GSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWD 215
Query: 174 VVTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDS 216
V+ V+ + P P I+ SED T+R+W S
Sbjct: 216 YQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHS 258
Score = 61.2 bits (147), Expect = 1e-09
Identities = 51/241 (21%), Positives = 93/241 (38%), Gaps = 57/241 (23%)
Query: 76 VSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWDLHGSS 135
V+G D + +N+ T V F+ H I +A P ++S D ++ +WD
Sbjct: 73 VTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKW 132
Query: 136 QPRQQLCGHAMVVTGLAVSP-DSSQLCTGSRDNTLLLWDVVTGQ---SVERASVSRNVVT 191
Q GH V + ++P D++Q + S D T+ +W + + ++E N +
Sbjct: 133 SCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCID 192
Query: 192 HLCWVPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCISCSNGF 251
+ + PY++ ++D+ +++WD +
Sbjct: 193 YYSGGDK-PYLISGADDRLVKIWD-----------------------------------Y 216
Query: 252 GGEGCEATLWDLRQTRNRICEYKGHFQTVASCVFLPRALALMPLIATSSHDCKVKIWNQD 311
+ C TL +GH Q V+ F P +P+I T S D V+IW+
Sbjct: 217 QNKTCVQTL-------------EGHAQNVSCASFHPE----LPIIITGSEDGTVRIWHSS 259
Query: 312 T 312
T
Sbjct: 260 T 260
Score = 38.5 bits (88), Expect = 0.010
Identities = 40/186 (21%), Positives = 76/186 (40%), Gaps = 24/186 (12%)
Query: 162 TGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWD-SRGLQ 220
TG+ D + +++ T + V + + + P +P+IL +S+D ++LWD +
Sbjct: 74 TGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWS 133
Query: 221 VAHMFPAKQHIQTYCEVSVDGHKCISCSNGFGGEGCEATL--WDLRQTRNRICEYKGHFQ 278
+ +F H ++ + N F + T+ W L + +GH +
Sbjct: 134 CSQVFEGHTHYVMQIVINPKDN------NQFASASLDRTIKVWQLGSSSPNFT-LEGHEK 186
Query: 279 TVASCVFLPRALALMPLIATSSHDCKVKIWNQDTGACLFTLSLDGSGPLTSLAVGDAISL 338
V +C+ P + + + D VKIW+ C+ TL G A ++
Sbjct: 187 GV-NCIDYYSG-GDKPYLISGADDRLVKIWDYQNKTCVQTLE------------GHAQNV 232
Query: 339 LCASFN 344
CASF+
Sbjct: 233 SCASFH 238
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 66.2 bits (160), Expect = 4e-11
Identities = 39/154 (25%), Positives = 71/154 (46%), Gaps = 11/154 (7%)
Query: 73 DLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWDLH 132
+L V+G + ++ ++ + +++ GH+ I + P S S+D + +WD+
Sbjct: 76 ELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDI- 134
Query: 133 GSSQPRQQLC-----GHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSR 187
R++ C GH+ V L SPD L + + D+T+ LWD+ G+ +
Sbjct: 135 -----RRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHT 189
Query: 188 NVVTHLCWVPREPYILQTSEDKTLRLWDSRGLQV 221
V + + P E + S D+T+R WD QV
Sbjct: 190 GPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQV 223
Score = 59.7 bits (143), Expect = 4e-09
Identities = 62/276 (22%), Positives = 103/276 (37%), Gaps = 15/276 (5%)
Query: 59 AHMDTVS--VVAALNSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQ 116
AH VS V+ + L +GG D V ++ N + GH + V
Sbjct: 18 AHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEEL 77
Query: 117 FFSASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVT 176
+ S+ + +WDL + R L GH + L P + +GS+D + LWD+
Sbjct: 78 IVAGSQSGSIRVWDLEAAKILRT-LMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRR 136
Query: 177 GQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCE 236
V R V L + P ++ ++D T++LWD ++ FP E
Sbjct: 137 KGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVE 196
Query: 237 VSVDGHKCISCSNGFGGEGCEATLWDLRQTRNRICEYKGHFQTVASCVFLPRALALMPLI 296
+ + S G WDL + + C +G V S +F P L
Sbjct: 197 FHPNEYLLAS-----GSSDRTIRFWDLEKFQVVSC-IEGEPGPVRSVLFNPDGCCLY--- 247
Query: 297 ATSSHDCKVKIWNQDTGACLFTLSLDGSGPLTSLAV 332
S ++++ + C F + L G + LA+
Sbjct: 248 --SGCQDSLRVYGWEPERC-FDVVLVNWGKVADLAI 280
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 66.2 bits (160), Expect = 4e-11
Identities = 59/247 (23%), Positives = 98/247 (39%), Gaps = 27/247 (10%)
Query: 77 SGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWD------ 130
S G DKT+ + +TG + K HE E+ A + S D+ V +W+
Sbjct: 632 SCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGEL 691
Query: 131 LHGSSQPRQQL-CGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNV 189
+H + +Q+ C H S L TGS D L LWD+ + N
Sbjct: 692 VHTYDEHSEQVNCCH------FTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNS 745
Query: 190 VTHLCWVPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCISCSN 249
V H + P + + S D TL+LWD+ KQ + D + C +
Sbjct: 746 VNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCS 805
Query: 250 GFGGEGC--------EATLWDLRQTRNRICEYKGHFQTVASCVFLPRALALMPLIATSSH 301
+ +G + LW+ +R+++ + +GH V +F P + + TSS
Sbjct: 806 -WSADGARIMVAAKNKIFLWN-TDSRSKVADCRGHLSWVHGVMFSPDGSSFL----TSSD 859
Query: 302 DCKVKIW 308
D +++W
Sbjct: 860 DQTIRLW 866
Score = 56.6 bits (135), Expect = 3e-08
Identities = 43/146 (29%), Positives = 63/146 (43%), Gaps = 9/146 (6%)
Query: 60 HMDTVSVVAALNSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFS 119
H +TV L + +S D TV +N TGN K F H+ + +++F S
Sbjct: 1000 HQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSS 1059
Query: 120 ASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQ- 178
S D+ +W P +L GH V A S DS+ L TG + + +W+V G+
Sbjct: 1060 TSADKTAKIWSF-DLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGEL 1118
Query: 179 -------SVERASVSRNVVTHLCWVP 197
S E A+ VT LC+ P
Sbjct: 1119 LHLCAPLSEEGAATHGGWVTDLCFSP 1144
Score = 54.3 bits (129), Expect = 2e-07
Identities = 39/166 (23%), Positives = 67/166 (40%), Gaps = 8/166 (4%)
Query: 144 HAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYIL 203
H V S D ++ + D TL ++ TG+ + + V + + +I
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
Query: 204 QTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCISCSNGFGGEGCEATLWDL 263
S DK +++W+S ++ H + C + H + + G C LWDL
Sbjct: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLAT---GSSDCFLKLWDL 730
Query: 264 RQTRNRICEYKGHFQTVASCVFLPRALALMPLIATSSHDCKVKIWN 309
Q R + GH +V C F P L+A+ S D +K+W+
Sbjct: 731 NQKECRNTMF-GHTNSVNHCRFSPDD----KLLASCSADGTLKLWD 771
Score = 53.5 bits (127), Expect = 3e-07
Identities = 77/349 (22%), Positives = 120/349 (34%), Gaps = 97/349 (27%)
Query: 59 AHMDTVSVVAALNSDLCVSG-GKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQF 117
AH D V A D ++ DK V +N TG +V + H ++ S
Sbjct: 655 AHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHL 714
Query: 118 FSA--SRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVV 175
A S D + +WDL+ + R + GH V SPD L + S D TL LWD
Sbjct: 715 LLATGSSDCFLKLWDLN-QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 773
Query: 176 TGQSVERASV--------------------------------------------SRNVVT 191
+ + +V SR+ V
Sbjct: 774 SANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVA 833
Query: 192 ----HLCWV------PREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCE----- 236
HL WV P L +S+D+T+RLW+++ + KQ + +
Sbjct: 834 DCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVM 893
Query: 237 -VSVDGHKCISCSNG--------------------------FGGEGCEATLWDLRQTRNR 269
++VD + + NG FG E + +L NR
Sbjct: 894 VLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILEL--VNNR 951
Query: 270 ICEYK-GHFQTVASCVFLPRALALMPLIATSSHDCKVKIWNQDTGACLF 317
I + + H +TV F L+ +SS D ++++WN C+F
Sbjct: 952 IFQSRFQHKKTVWHIQFTADEKTLI----SSSDDAEIQVWNWQLDKCIF 996
Score = 37.7 bits (86), Expect = 0.016
Identities = 29/82 (35%), Positives = 36/82 (43%), Gaps = 12/82 (14%)
Query: 238 SVDGHKCISCSNGFGGEGCEATLWDLR-QTRNRICEYKGHFQTVASCVFLPRALALMPLI 296
S DG + SC G + TL + +T ++ E K H V C F I
Sbjct: 624 SEDGQRIASC-------GADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR----FI 672
Query: 297 ATSSHDCKVKIWNQDTGACLFT 318
AT S D KVKIWN TG + T
Sbjct: 673 ATCSVDKKVKIWNSMTGELVHT 694
Score = 37.0 bits (84), Expect = 0.028
Identities = 32/132 (24%), Positives = 53/132 (40%), Gaps = 8/132 (6%)
Query: 188 NVVTHLCWVPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCISC 247
+ V H C+ I DKTL+++ + + A + C S D +C
Sbjct: 616 DAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATC 675
Query: 248 SNGFGGEGCEATLWDLRQTRNRICEYKGHFQTVASCVFLPRALALMPLIATSSHDCKVKI 307
S + +W+ T + Y H + V C F + L L+AT S DC +K+
Sbjct: 676 S-----VDKKVKIWN-SMTGELVHTYDEHSEQVNCCHFTNSSHHL--LLATGSSDCFLKL 727
Query: 308 WNQDTGACLFTL 319
W+ + C T+
Sbjct: 728 WDLNQKECRNTM 739
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 66.2 bits (160), Expect = 4e-11
Identities = 59/247 (23%), Positives = 98/247 (39%), Gaps = 27/247 (10%)
Query: 77 SGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWD------ 130
S G DKT+ + +TG + K HE E+ A + S D+ V +W+
Sbjct: 621 SCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGEL 680
Query: 131 LHGSSQPRQQL-CGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNV 189
+H + +Q+ C H S L TGS D L LWD+ + N
Sbjct: 681 VHTYDEHSEQVNCCH------FTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNS 734
Query: 190 VTHLCWVPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCISCSN 249
V H + P + + S D TL+LWD+ KQ + D + C +
Sbjct: 735 VNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCS 794
Query: 250 GFGGEGC--------EATLWDLRQTRNRICEYKGHFQTVASCVFLPRALALMPLIATSSH 301
+ +G + LW+ +R+++ + +GH V +F P + + TSS
Sbjct: 795 -WSADGARIMVAAKNKIFLWN-TDSRSKVADCRGHLSWVHGVMFSPDGSSFL----TSSD 848
Query: 302 DCKVKIW 308
D +++W
Sbjct: 849 DQTIRLW 855
Score = 56.6 bits (135), Expect = 3e-08
Identities = 43/146 (29%), Positives = 63/146 (43%), Gaps = 9/146 (6%)
Query: 60 HMDTVSVVAALNSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFS 119
H +TV L + +S D TV +N TGN K F H+ + +++F S
Sbjct: 989 HQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSS 1048
Query: 120 ASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQ- 178
S D+ +W P +L GH V A S DS+ L TG + + +W+V G+
Sbjct: 1049 TSADKTAKIWSF-DLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGEL 1107
Query: 179 -------SVERASVSRNVVTHLCWVP 197
S E A+ VT LC+ P
Sbjct: 1108 LHLCAPLSEEGAATHGGWVTDLCFSP 1133
Score = 54.3 bits (129), Expect = 2e-07
Identities = 39/166 (23%), Positives = 67/166 (40%), Gaps = 8/166 (4%)
Query: 144 HAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYIL 203
H V S D ++ + D TL ++ TG+ + + V + + +I
Sbjct: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
Query: 204 QTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCISCSNGFGGEGCEATLWDL 263
S DK +++W+S ++ H + C + H + + G C LWDL
Sbjct: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLAT---GSSDCFLKLWDL 719
Query: 264 RQTRNRICEYKGHFQTVASCVFLPRALALMPLIATSSHDCKVKIWN 309
Q R + GH +V C F P L+A+ S D +K+W+
Sbjct: 720 NQKECRNTMF-GHTNSVNHCRFSPDD----KLLASCSADGTLKLWD 760
Score = 53.5 bits (127), Expect = 3e-07
Identities = 77/349 (22%), Positives = 120/349 (34%), Gaps = 97/349 (27%)
Query: 59 AHMDTVSVVAALNSDLCVSG-GKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQF 117
AH D V A D ++ DK V +N TG +V + H ++ S
Sbjct: 644 AHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHL 703
Query: 118 FSA--SRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVV 175
A S D + +WDL+ + R + GH V SPD L + S D TL LWD
Sbjct: 704 LLATGSSDCFLKLWDLN-QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 762
Query: 176 TGQSVERASV--------------------------------------------SRNVVT 191
+ + +V SR+ V
Sbjct: 763 SANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVA 822
Query: 192 ----HLCWV------PREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCE----- 236
HL WV P L +S+D+T+RLW+++ + KQ + +
Sbjct: 823 DCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVM 882
Query: 237 -VSVDGHKCISCSNG--------------------------FGGEGCEATLWDLRQTRNR 269
++VD + + NG FG E + +L NR
Sbjct: 883 VLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILEL--VNNR 940
Query: 270 ICEYK-GHFQTVASCVFLPRALALMPLIATSSHDCKVKIWNQDTGACLF 317
I + + H +TV F L+ +SS D ++++WN C+F
Sbjct: 941 IFQSRFQHKKTVWHIQFTADEKTLI----SSSDDAEIQVWNWQLDKCIF 985
Score = 37.7 bits (86), Expect = 0.016
Identities = 29/82 (35%), Positives = 36/82 (43%), Gaps = 12/82 (14%)
Query: 238 SVDGHKCISCSNGFGGEGCEATLWDLR-QTRNRICEYKGHFQTVASCVFLPRALALMPLI 296
S DG + SC G + TL + +T ++ E K H V C F I
Sbjct: 613 SEDGQRIASC-------GADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR----FI 661
Query: 297 ATSSHDCKVKIWNQDTGACLFT 318
AT S D KVKIWN TG + T
Sbjct: 662 ATCSVDKKVKIWNSMTGELVHT 683
Score = 37.0 bits (84), Expect = 0.028
Identities = 32/132 (24%), Positives = 53/132 (40%), Gaps = 8/132 (6%)
Query: 188 NVVTHLCWVPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCISC 247
+ V H C+ I DKTL+++ + + A + C S D +C
Sbjct: 605 DAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATC 664
Query: 248 SNGFGGEGCEATLWDLRQTRNRICEYKGHFQTVASCVFLPRALALMPLIATSSHDCKVKI 307
S + +W+ T + Y H + V C F + L L+AT S DC +K+
Sbjct: 665 S-----VDKKVKIWN-SMTGELVHTYDEHSEQVNCCHFTNSSHHL--LLATGSSDCFLKL 716
Query: 308 WNQDTGACLFTL 319
W+ + C T+
Sbjct: 717 WDLNQKECRNTM 728
>gi|8923881 WD SOCS-box protein 2 [Homo sapiens]
Length = 404
Score = 65.9 bits (159), Expect = 6e-11
Identities = 61/210 (29%), Positives = 91/210 (43%), Gaps = 34/210 (16%)
Query: 133 GSSQPRQQLCGHAMVVTGLAVSPDSSQ--------------------LCTGSRDNTLLLW 172
G P+++ +V GLA SP S L TG D + +W
Sbjct: 79 GRGSPKEKTLDCGQIVWGLAFSPWPSPPSRKLWARHHPQVPDVSCLVLATGLNDGQIKIW 138
Query: 173 DVVTGQSVERASVSRNVVTHLCWVPREPYIL-QTSEDKTLRLWD--SRGLQVAHMFPAKQ 229
+V TG + S ++VV L + P IL S DKTLR+WD G Q+ + Q
Sbjct: 139 EVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQIQVLSGHLQ 198
Query: 230 HIQTYCEVSVDGHKCISCSNGFGGEGCEATLWDLRQTRNRICEYKGHFQTVASCVFLPRA 289
+ C +S D C + G + LW +R + I + +GH +V SC F P +
Sbjct: 199 WVYC-CSISPD---CSMLCSAAGEK--SVFLWSMR-SYTLIRKLEGHQSSVVSCDFSPDS 251
Query: 290 LALMPLIATSSHDCKVKIWNQDTGACLFTL 319
L+ T+S+D V +W+ TG L +L
Sbjct: 252 ----ALLVTASYDTNVIMWDPYTGERLRSL 277
Score = 65.9 bits (159), Expect = 6e-11
Identities = 61/245 (24%), Positives = 99/245 (40%), Gaps = 25/245 (10%)
Query: 77 SGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFF-SASRDRMVMMWDLHGSS 135
+G D + + +TG ++ GH+ + ++ P S SASRD+ + +WDL+
Sbjct: 128 TGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHG 187
Query: 136 QPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCW 195
+ Q L GH V ++SPD S LC+ + + ++ LW + + + + ++ V +
Sbjct: 188 KQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDF 247
Query: 196 VPREPYILQTSEDKTLRLWDS------RGLQVAHMFPAKQHIQTYCEVSVDGHKCISCSN 249
P ++ S D + +WD R L + PA D H S
Sbjct: 248 SPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMD--------DSDVHISSLRSV 299
Query: 250 GFGGEGCE-ATLWDLRQTRNRICEYK-----GHFQTVASCVFLPRALALMPLIATSSHDC 303
F EG AT+ D R R E K C F P +IAT + D
Sbjct: 300 CFSPEGLYLATVADDRLLRIWALELKTPIAFAPMTNGLCCTFFPHG----GVIATGTRDG 355
Query: 304 KVKIW 308
V+ W
Sbjct: 356 HVQFW 360
>gi|153791298 mitogen-activated protein kinase organizer 1 [Homo
sapiens]
Length = 315
Score = 65.5 bits (158), Expect = 7e-11
Identities = 68/267 (25%), Positives = 122/267 (45%), Gaps = 22/267 (8%)
Query: 70 LNSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMW 129
++ + C++ G DKT+ +N G +++ + GH +E+ A +S S D+ V++W
Sbjct: 35 VDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLW 94
Query: 130 DLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVT--GQSVERASVSR 187
D+ S Q ++ GHA V + + +++ + +GS D+++ WD + + V+ +R
Sbjct: 95 DV-ASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPVQTLDEAR 153
Query: 188 NVVTHLCWVPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCISC 247
+ V+ + E IL S D +R +D L++ +F C +C
Sbjct: 154 DGVSSVKVSDHE--ILAGSVDGRVRRYD---LRMGQLFSDYVGSPITCTCFSRDGQCTLV 208
Query: 248 SNGFGGEGCEATLWDL-RQTRNRICEYKGH--FQTVASCVFLPRALALMPLIATSSHDCK 304
S+ ++TL L + T + EYKGH + C R + + S D K
Sbjct: 209 SS------LDSTLRLLDKDTGELLGEYKGHKNQEYKLDCCLSERDTH----VVSCSEDGK 258
Query: 305 VKIWNQDTGACLFTLSLDGSGPLTSLA 331
V W+ GA L + GSG + SLA
Sbjct: 259 VFFWDLVEGALALALPV-GSGVVQSLA 284
Score = 31.2 bits (69), Expect = 1.5
Identities = 31/162 (19%), Positives = 64/162 (39%), Gaps = 21/162 (12%)
Query: 62 DTVSVVAALNSDLCVSGGKDKTVVAYNWKTGNVVKRFKG---------HEHEITKVACIP 112
D VS V + ++ ++G D V Y+ + G + + G + + T V+ +
Sbjct: 154 DGVSSVKVSDHEI-LAGSVDGRVRRYDLRMGQLFSDYVGSPITCTCFSRDGQCTLVSSLD 212
Query: 113 KSSQFFSASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLW 172
+ + ++ + H + + + C +S + + + S D + W
Sbjct: 213 STLRLLDKDTGELLGEYKGHKNQEYKLDCC----------LSERDTHVVSCSEDGKVFFW 262
Query: 173 DVVTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLW 214
D+V G V VV L + P EP +L T+ +++ W
Sbjct: 263 DLVEGALALALPVGSGVVQSLAYHPTEPCLL-TAMGGSVQCW 303
>gi|14150114 mitogen-activated protein kinase organizer 1 [Homo
sapiens]
Length = 315
Score = 65.5 bits (158), Expect = 7e-11
Identities = 68/267 (25%), Positives = 122/267 (45%), Gaps = 22/267 (8%)
Query: 70 LNSDLCVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMW 129
++ + C++ G DKT+ +N G +++ + GH +E+ A +S S D+ V++W
Sbjct: 35 VDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLW 94
Query: 130 DLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVT--GQSVERASVSR 187
D+ S Q ++ GHA V + + +++ + +GS D+++ WD + + V+ +R
Sbjct: 95 DV-ASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPVQTLDEAR 153
Query: 188 NVVTHLCWVPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCISC 247
+ V+ + E IL S D +R +D L++ +F C +C
Sbjct: 154 DGVSSVKVSDHE--ILAGSVDGRVRRYD---LRMGQLFSDYVGSPITCTCFSRDGQCTLV 208
Query: 248 SNGFGGEGCEATLWDL-RQTRNRICEYKGH--FQTVASCVFLPRALALMPLIATSSHDCK 304
S+ ++TL L + T + EYKGH + C R + + S D K
Sbjct: 209 SS------LDSTLRLLDKDTGELLGEYKGHKNQEYKLDCCLSERDTH----VVSCSEDGK 258
Query: 305 VKIWNQDTGACLFTLSLDGSGPLTSLA 331
V W+ GA L + GSG + SLA
Sbjct: 259 VFFWDLVEGALALALPV-GSGVVQSLA 284
Score = 31.2 bits (69), Expect = 1.5
Identities = 31/162 (19%), Positives = 64/162 (39%), Gaps = 21/162 (12%)
Query: 62 DTVSVVAALNSDLCVSGGKDKTVVAYNWKTGNVVKRFKG---------HEHEITKVACIP 112
D VS V + ++ ++G D V Y+ + G + + G + + T V+ +
Sbjct: 154 DGVSSVKVSDHEI-LAGSVDGRVRRYDLRMGQLFSDYVGSPITCTCFSRDGQCTLVSSLD 212
Query: 113 KSSQFFSASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLW 172
+ + ++ + H + + + C +S + + + S D + W
Sbjct: 213 STLRLLDKDTGELLGEYKGHKNQEYKLDCC----------LSERDTHVVSCSEDGKVFFW 262
Query: 173 DVVTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLW 214
D+V G V VV L + P EP +L T+ +++ W
Sbjct: 263 DLVEGALALALPVGSGVVQSLAYHPTEPCLL-TAMGGSVQCW 303
>gi|13129110 WD repeat domain 77 [Homo sapiens]
Length = 342
Score = 65.1 bits (157), Expect = 1e-10
Identities = 52/176 (29%), Positives = 83/176 (47%), Gaps = 8/176 (4%)
Query: 60 HMDTVSVVAALNSDL-CVSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIP-KSSQF 117
H D VS V+ L+S VSG KD + ++ V+ ++ H ++T VA P K S F
Sbjct: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183
Query: 118 FSASRDRMVMMWDLHGSSQPRQQLC-GHAMVVTGLAVSPDSSQLCT-GSRDNTLLLWDVV 175
S S D +++WD Q C + T LA P S++ G + T+ L D
Sbjct: 184 LSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTK 243
Query: 176 TGQSVERASVSRNVVTHLCWVPRE-PYILQTSEDKTLRLWDSRGLQVAHMFPAKQH 230
+ V ++V VT L + P P++ SED +L + DS ++ +F ++ H
Sbjct: 244 STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDS---SLSELFRSQAH 296
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 64.3 bits (155), Expect = 2e-10
Identities = 74/292 (25%), Positives = 114/292 (39%), Gaps = 56/292 (19%)
Query: 99 KGHEHEITKVACIPKSSQFFSASRDRMVMMWDLH-----GSSQPRQQLC----GHAMV-- 147
+GHE E+ A P S S S D +W+L+ GS+Q + C GH +
Sbjct: 176 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 235
Query: 148 --VTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQT 205
VT L + D + L GS D +W G + + L W + Y+L
Sbjct: 236 KDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKKGNYVLSA 294
Query: 206 SEDKTLRLWDSRGLQVAHMFPAK---------QHIQTYCEVSVDGHKCISCSNGFGGEGC 256
DKT +WD+ + FP Q+ T+ S D CI GC
Sbjct: 295 GVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTD--MCIHVCR----LGC 348
Query: 257 EATLWDLRQTRNRICEYKGHFQTVASCVFLPRALALMPLIATSSHDCKVKIWNQDTGAC- 315
+ + + ++GH V + + P + L+A+ S D +KIW+ AC
Sbjct: 349 D----------HPVKTFQGHTNEVNAIKWDPSGM----LLASCSDDMTLKIWSMKQDACV 394
Query: 316 ---------LFTLSLDGSGPLTSLAVGDAISLLCASFNRGIHLLRMDHSQGL 358
++T+ +GP TS +I L ASF+ + L D QG+
Sbjct: 395 HDLQAHSKEIYTIKWSPTGPATS-NPNSSIMLASASFDSTVRL--WDVEQGV 443
Score = 52.8 bits (125), Expect = 5e-07
Identities = 40/155 (25%), Positives = 64/155 (41%), Gaps = 20/155 (12%)
Query: 95 VKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWDLHGSSQPRQQLCGHAMVV------ 148
VK F+GH +E+ + P S S D + +W + +Q C H +
Sbjct: 352 VKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSM------KQDACVHDLQAHSKEIY 405
Query: 149 ------TGLAVS-PDSS-QLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREP 200
TG A S P+SS L + S D+T+ LWDV G + V + + P
Sbjct: 406 TIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGK 465
Query: 201 YILQTSEDKTLRLWDSRGLQVAHMFPAKQHIQTYC 235
Y+ S DK + +W+++ + H + I C
Sbjct: 466 YLASGSFDKYVHIWNTQSGSLVHSYQGTGGIFEVC 500
Score = 47.4 bits (111), Expect = 2e-05
Identities = 38/149 (25%), Positives = 56/149 (37%), Gaps = 11/149 (7%)
Query: 76 VSGGKDKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWDLHGSS 135
+S G DKT + ++ TG ++F H V + F S S D + + L G
Sbjct: 292 LSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDW-QNNMTFASCSTDMCIHVCRL-GCD 349
Query: 136 QPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCW 195
P + GH V + P L + S D TL +W + V + + W
Sbjct: 350 HPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKW 409
Query: 196 VPREP---------YILQTSEDKTLRLWD 215
P P + S D T+RLWD
Sbjct: 410 SPTGPATSNPNSSIMLASASFDSTVRLWD 438
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.133 0.417
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,251,165
Number of Sequences: 37866
Number of extensions: 597219
Number of successful extensions: 3474
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 205
Number of HSP's successfully gapped in prelim test: 108
Number of HSP's that attempted gapping in prelim test: 1501
Number of HSP's gapped (non-prelim): 1188
length of query: 366
length of database: 18,247,518
effective HSP length: 104
effective length of query: 262
effective length of database: 14,309,454
effective search space: 3749076948
effective search space used: 3749076948
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.