Guide to the Human Genome
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Search of human proteins with 21626468

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21626468 zinc finger protein 638 [Homo sapiens]
         (1978 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|62526045 zinc finger protein 638 [Homo sapiens]                   3895   0.0  
gi|21626468 zinc finger protein 638 [Homo sapiens]                   3895   0.0  
gi|62750354 matrin 3 [Homo sapiens]                                    72   4e-12
gi|21626466 matrin 3 [Homo sapiens]                                    72   4e-12
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             65   9e-10
gi|87299628 biorientation of chromosomes in cell division 1-like...    62   7e-09
gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sap...    62   7e-09
gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sap...    62   7e-09
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]        62   7e-09
gi|21040326 SON DNA-binding protein isoform F [Homo sapiens]           61   9e-09
gi|116812577 LUC7-like 2 [Homo sapiens]                                61   9e-09
gi|21040314 SON DNA-binding protein isoform B [Homo sapiens]           60   2e-08
gi|197276594 RNA binding motif protein 20 [Homo sapiens]               59   6e-08
gi|109637759 calpastatin isoform f [Homo sapiens]                      58   1e-07
gi|4759100 splicing factor, arginine/serine-rich 11 [Homo sapiens]     56   4e-07
gi|224548936 hypothetical protein LOC100170229 [Homo sapiens]          55   9e-07
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     54   2e-06
gi|62244004 modulator of estrogen induced transcription isoform ...    54   2e-06
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ...    52   6e-06
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ...    52   6e-06
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]                       52   6e-06
gi|104526627 triadin [Homo sapiens]                                    52   6e-06
gi|221219020 NYD-SP11 protein [Homo sapiens]                           52   8e-06
gi|33356174 pinin, desmosome associated protein [Homo sapiens]         52   8e-06
gi|23111062 splicing factor, arginine/serine-rich 8 [Homo sapiens]     51   1e-05
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [...    51   1e-05
gi|109637771 calpastatin isoform l [Homo sapiens]                      51   1e-05
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ...    51   1e-05
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [...    51   1e-05
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     50   2e-05

>gi|62526045 zinc finger protein 638 [Homo sapiens]
          Length = 1978

 Score = 3895 bits (10102), Expect = 0.0
 Identities = 1978/1978 (100%), Positives = 1978/1978 (100%)

Query: 1    MSRPRFNPRGDFPLQRPRAPNPSGMRPPGPFMRPGSMGLPRFYPAGRARGIPHRFAGHES 60
            MSRPRFNPRGDFPLQRPRAPNPSGMRPPGPFMRPGSMGLPRFYPAGRARGIPHRFAGHES
Sbjct: 1    MSRPRFNPRGDFPLQRPRAPNPSGMRPPGPFMRPGSMGLPRFYPAGRARGIPHRFAGHES 60

Query: 61   YQNMGPQRMNVQVTQHRTDPRLTKEKLDFHEAQQKKGKPHGSRWDDEPHISASVAVKQSS 120
            YQNMGPQRMNVQVTQHRTDPRLTKEKLDFHEAQQKKGKPHGSRWDDEPHISASVAVKQSS
Sbjct: 61   YQNMGPQRMNVQVTQHRTDPRLTKEKLDFHEAQQKKGKPHGSRWDDEPHISASVAVKQSS 120

Query: 121  VTQVTEQSPKVQSRYTKESASSILASFGLSNEDLEELSRYPDEQLTPENMPLILRDIRMR 180
            VTQVTEQSPKVQSRYTKESASSILASFGLSNEDLEELSRYPDEQLTPENMPLILRDIRMR
Sbjct: 121  VTQVTEQSPKVQSRYTKESASSILASFGLSNEDLEELSRYPDEQLTPENMPLILRDIRMR 180

Query: 181  KMGRRLPNLPSQSRNKETLGSEAVSSNVIDYGHASKYGYTEDPLEVRIYDPEIPTDEVEN 240
            KMGRRLPNLPSQSRNKETLGSEAVSSNVIDYGHASKYGYTEDPLEVRIYDPEIPTDEVEN
Sbjct: 181  KMGRRLPNLPSQSRNKETLGSEAVSSNVIDYGHASKYGYTEDPLEVRIYDPEIPTDEVEN 240

Query: 241  EFQSQQNISASVPNPNVICNSMFPVEDVFRQMDFPGESSNNRSFFSVESGTKMSGLHISG 300
            EFQSQQNISASVPNPNVICNSMFPVEDVFRQMDFPGESSNNRSFFSVESGTKMSGLHISG
Sbjct: 241  EFQSQQNISASVPNPNVICNSMFPVEDVFRQMDFPGESSNNRSFFSVESGTKMSGLHISG 300

Query: 301  GQSVLEPIKSVNQSINQTVSQTMSQSLIPPSMNQQPFSSELISSVSQQERIPHEPVINSS 360
            GQSVLEPIKSVNQSINQTVSQTMSQSLIPPSMNQQPFSSELISSVSQQERIPHEPVINSS
Sbjct: 301  GQSVLEPIKSVNQSINQTVSQTMSQSLIPPSMNQQPFSSELISSVSQQERIPHEPVINSS 360

Query: 361  NVHVGSRGSKKNYQSQADIPIRSPFGIVKASWLPKFSHADAQKMKRLPTPSMMNDYYAAS 420
            NVHVGSRGSKKNYQSQADIPIRSPFGIVKASWLPKFSHADAQKMKRLPTPSMMNDYYAAS
Sbjct: 361  NVHVGSRGSKKNYQSQADIPIRSPFGIVKASWLPKFSHADAQKMKRLPTPSMMNDYYAAS 420

Query: 421  PRIFPHLCSLCNVECSHLKDWIQHQNTSTHIESCRQLRQQYPDWNPEILPSRRNEGNRKE 480
            PRIFPHLCSLCNVECSHLKDWIQHQNTSTHIESCRQLRQQYPDWNPEILPSRRNEGNRKE
Sbjct: 421  PRIFPHLCSLCNVECSHLKDWIQHQNTSTHIESCRQLRQQYPDWNPEILPSRRNEGNRKE 480

Query: 481  NETPRRRSHSPSPRRSRRSSSSHRFRRSRSPMHYMYRPRSRSPRICHRFISRYRSRSRSR 540
            NETPRRRSHSPSPRRSRRSSSSHRFRRSRSPMHYMYRPRSRSPRICHRFISRYRSRSRSR
Sbjct: 481  NETPRRRSHSPSPRRSRRSSSSHRFRRSRSPMHYMYRPRSRSPRICHRFISRYRSRSRSR 540

Query: 541  SPYRIRNPFRGSPKCFRSVSPERMSRRSVRSSDRKKALEDVVQRSGHGTEFNKQKHLEAA 600
            SPYRIRNPFRGSPKCFRSVSPERMSRRSVRSSDRKKALEDVVQRSGHGTEFNKQKHLEAA
Sbjct: 541  SPYRIRNPFRGSPKCFRSVSPERMSRRSVRSSDRKKALEDVVQRSGHGTEFNKQKHLEAA 600

Query: 601  DKGHSPAQKPKTSSGTKPSVKPTSATKSDSNLGGHSIRCKSKNLEDDTLSECKQVSDKAV 660
            DKGHSPAQKPKTSSGTKPSVKPTSATKSDSNLGGHSIRCKSKNLEDDTLSECKQVSDKAV
Sbjct: 601  DKGHSPAQKPKTSSGTKPSVKPTSATKSDSNLGGHSIRCKSKNLEDDTLSECKQVSDKAV 660

Query: 661  SLQRKLRKEQSLHYGSVLLITELPEDGCTEEDVRKLFQPFGKVNDVLIVPYRKEAYLEME 720
            SLQRKLRKEQSLHYGSVLLITELPEDGCTEEDVRKLFQPFGKVNDVLIVPYRKEAYLEME
Sbjct: 661  SLQRKLRKEQSLHYGSVLLITELPEDGCTEEDVRKLFQPFGKVNDVLIVPYRKEAYLEME 720

Query: 721  FKEAITAIMKYIETTPLTIKGKSVKICVPGKKKAQNKEVKKKTLESKKVSASTLKRDADA 780
            FKEAITAIMKYIETTPLTIKGKSVKICVPGKKKAQNKEVKKKTLESKKVSASTLKRDADA
Sbjct: 721  FKEAITAIMKYIETTPLTIKGKSVKICVPGKKKAQNKEVKKKTLESKKVSASTLKRDADA 780

Query: 781  SKAVEIVTSTSAAKTGQAKASVAKVNKSTGKSASSVKSVVTVAVKGNKASIKTAKSGGKK 840
            SKAVEIVTSTSAAKTGQAKASVAKVNKSTGKSASSVKSVVTVAVKGNKASIKTAKSGGKK
Sbjct: 781  SKAVEIVTSTSAAKTGQAKASVAKVNKSTGKSASSVKSVVTVAVKGNKASIKTAKSGGKK 840

Query: 841  SLEAKKTGNVKNKDSNKPVTIPENSEIKTSIEVKATENCAKEAISDAALEATENEPLNKE 900
            SLEAKKTGNVKNKDSNKPVTIPENSEIKTSIEVKATENCAKEAISDAALEATENEPLNKE
Sbjct: 841  SLEAKKTGNVKNKDSNKPVTIPENSEIKTSIEVKATENCAKEAISDAALEATENEPLNKE 900

Query: 901  TEEMCVMLVSNLPNKGYSVEEVYDLAKPFGGLKDILILSSHKKAYIEINRKAAESMVKFY 960
            TEEMCVMLVSNLPNKGYSVEEVYDLAKPFGGLKDILILSSHKKAYIEINRKAAESMVKFY
Sbjct: 901  TEEMCVMLVSNLPNKGYSVEEVYDLAKPFGGLKDILILSSHKKAYIEINRKAAESMVKFY 960

Query: 961  TCFPVLMDGNQLSISMAPENMNIKDEEAIFITLVKENDPEANIDTIYDRFVHLDNLPEDG 1020
            TCFPVLMDGNQLSISMAPENMNIKDEEAIFITLVKENDPEANIDTIYDRFVHLDNLPEDG
Sbjct: 961  TCFPVLMDGNQLSISMAPENMNIKDEEAIFITLVKENDPEANIDTIYDRFVHLDNLPEDG 1020

Query: 1021 LQCVLCVGLQFGKVDHHVFISNRNKAILQLDSPESAQSMYSFLKQNPQNIGDHMLTCSLS 1080
            LQCVLCVGLQFGKVDHHVFISNRNKAILQLDSPESAQSMYSFLKQNPQNIGDHMLTCSLS
Sbjct: 1021 LQCVLCVGLQFGKVDHHVFISNRNKAILQLDSPESAQSMYSFLKQNPQNIGDHMLTCSLS 1080

Query: 1081 PKIDLPEVQIEHDPELEKESPGLKNSPIDESEVQTATDSPSVKPNELEEESTPSIQTETL 1140
            PKIDLPEVQIEHDPELEKESPGLKNSPIDESEVQTATDSPSVKPNELEEESTPSIQTETL
Sbjct: 1081 PKIDLPEVQIEHDPELEKESPGLKNSPIDESEVQTATDSPSVKPNELEEESTPSIQTETL 1140

Query: 1141 VQQEEPCEEEAEKATCDSDFAVETLELETQGEEVKEEIPLVASASVSIEQFTENAEECAL 1200
            VQQEEPCEEEAEKATCDSDFAVETLELETQGEEVKEEIPLVASASVSIEQFTENAEECAL
Sbjct: 1141 VQQEEPCEEEAEKATCDSDFAVETLELETQGEEVKEEIPLVASASVSIEQFTENAEECAL 1200

Query: 1201 NQQMFNSDLEKKGAEIINPKTALLPSDSVFAEERNLKGILEESPSEAEDFISGITQTMVE 1260
            NQQMFNSDLEKKGAEIINPKTALLPSDSVFAEERNLKGILEESPSEAEDFISGITQTMVE
Sbjct: 1201 NQQMFNSDLEKKGAEIINPKTALLPSDSVFAEERNLKGILEESPSEAEDFISGITQTMVE 1260

Query: 1261 AVAEVEKNETVSEILPSTCIVTLVPGIPTGDEKTVDKKNISEKKGNMDEKEEKEFNTKET 1320
            AVAEVEKNETVSEILPSTCIVTLVPGIPTGDEKTVDKKNISEKKGNMDEKEEKEFNTKET
Sbjct: 1261 AVAEVEKNETVSEILPSTCIVTLVPGIPTGDEKTVDKKNISEKKGNMDEKEEKEFNTKET 1320

Query: 1321 RMDLQIGTEKAEKNEGRMDAEKVEKMAAMKEKPAENTLFKAYPNKGVGQANKPDETSKTS 1380
            RMDLQIGTEKAEKNEGRMDAEKVEKMAAMKEKPAENTLFKAYPNKGVGQANKPDETSKTS
Sbjct: 1321 RMDLQIGTEKAEKNEGRMDAEKVEKMAAMKEKPAENTLFKAYPNKGVGQANKPDETSKTS 1380

Query: 1381 ILAVSDVSSSKPSIKAVIVSSPKAKATVSKTENQKSFPKSVPRDQINAEKKLSAKEFGLL 1440
            ILAVSDVSSSKPSIKAVIVSSPKAKATVSKTENQKSFPKSVPRDQINAEKKLSAKEFGLL
Sbjct: 1381 ILAVSDVSSSKPSIKAVIVSSPKAKATVSKTENQKSFPKSVPRDQINAEKKLSAKEFGLL 1440

Query: 1441 KPTSARSGLAESSSKFKPTQSSLTRGGSGRISALQGKLSKLDYRDITKQSQETEARPSIM 1500
            KPTSARSGLAESSSKFKPTQSSLTRGGSGRISALQGKLSKLDYRDITKQSQETEARPSIM
Sbjct: 1441 KPTSARSGLAESSSKFKPTQSSLTRGGSGRISALQGKLSKLDYRDITKQSQETEARPSIM 1500

Query: 1501 KRDDSNNKTLAEQNTKNPKSTTGRSSKSKEEPLFPFNLDEFVTVDEVIEEVNPSQAKQNP 1560
            KRDDSNNKTLAEQNTKNPKSTTGRSSKSKEEPLFPFNLDEFVTVDEVIEEVNPSQAKQNP
Sbjct: 1501 KRDDSNNKTLAEQNTKNPKSTTGRSSKSKEEPLFPFNLDEFVTVDEVIEEVNPSQAKQNP 1560

Query: 1561 LKGKRKETLKNVPFSELNLKKKKGKTSTPRGVEGELSFVTLDEIGEEEDAAAHLAQALVT 1620
            LKGKRKETLKNVPFSELNLKKKKGKTSTPRGVEGELSFVTLDEIGEEEDAAAHLAQALVT
Sbjct: 1561 LKGKRKETLKNVPFSELNLKKKKGKTSTPRGVEGELSFVTLDEIGEEEDAAAHLAQALVT 1620

Query: 1621 VDEVIDEEELNMEEMVKNSNSLFTLDELIDQDDCISHSEPKDVTVLSVAEEQDLLKQERL 1680
            VDEVIDEEELNMEEMVKNSNSLFTLDELIDQDDCISHSEPKDVTVLSVAEEQDLLKQERL
Sbjct: 1621 VDEVIDEEELNMEEMVKNSNSLFTLDELIDQDDCISHSEPKDVTVLSVAEEQDLLKQERL 1680

Query: 1681 VTVDEIGEVEELPLNESADITFATLNTKGNEGDTVRDSIGFISSQVPEDPSTLVTVDEIQ 1740
            VTVDEIGEVEELPLNESADITFATLNTKGNEGDTVRDSIGFISSQVPEDPSTLVTVDEIQ
Sbjct: 1681 VTVDEIGEVEELPLNESADITFATLNTKGNEGDTVRDSIGFISSQVPEDPSTLVTVDEIQ 1740

Query: 1741 DDSSDLHLVTLDEVTEEDEDSLADFNNLKEELNFVTVDEVGEEEDGDNDLKVELAQSKND 1800
            DDSSDLHLVTLDEVTEEDEDSLADFNNLKEELNFVTVDEVGEEEDGDNDLKVELAQSKND
Sbjct: 1741 DDSSDLHLVTLDEVTEEDEDSLADFNNLKEELNFVTVDEVGEEEDGDNDLKVELAQSKND 1800

Query: 1801 HPTDKKGNRKKRAVDTKKTKLESLSQVGPVNENVMEEDLKTMIERHLTAKTPTKRVRIGK 1860
            HPTDKKGNRKKRAVDTKKTKLESLSQVGPVNENVMEEDLKTMIERHLTAKTPTKRVRIGK
Sbjct: 1801 HPTDKKGNRKKRAVDTKKTKLESLSQVGPVNENVMEEDLKTMIERHLTAKTPTKRVRIGK 1860

Query: 1861 TLPSEKAVVTEPAKGEEAFQMSEVDEESGLKDSEPERKRKKTEDSSSGKSVASDVPEELD 1920
            TLPSEKAVVTEPAKGEEAFQMSEVDEESGLKDSEPERKRKKTEDSSSGKSVASDVPEELD
Sbjct: 1861 TLPSEKAVVTEPAKGEEAFQMSEVDEESGLKDSEPERKRKKTEDSSSGKSVASDVPEELD 1920

Query: 1921 FLVPKAGFFCPICSLFYSGEKAMTNHCKSTRHKQNTEKFMAKQRKEKEQNEAEERSSR 1978
            FLVPKAGFFCPICSLFYSGEKAMTNHCKSTRHKQNTEKFMAKQRKEKEQNEAEERSSR
Sbjct: 1921 FLVPKAGFFCPICSLFYSGEKAMTNHCKSTRHKQNTEKFMAKQRKEKEQNEAEERSSR 1978


>gi|21626468 zinc finger protein 638 [Homo sapiens]
          Length = 1978

 Score = 3895 bits (10102), Expect = 0.0
 Identities = 1978/1978 (100%), Positives = 1978/1978 (100%)

Query: 1    MSRPRFNPRGDFPLQRPRAPNPSGMRPPGPFMRPGSMGLPRFYPAGRARGIPHRFAGHES 60
            MSRPRFNPRGDFPLQRPRAPNPSGMRPPGPFMRPGSMGLPRFYPAGRARGIPHRFAGHES
Sbjct: 1    MSRPRFNPRGDFPLQRPRAPNPSGMRPPGPFMRPGSMGLPRFYPAGRARGIPHRFAGHES 60

Query: 61   YQNMGPQRMNVQVTQHRTDPRLTKEKLDFHEAQQKKGKPHGSRWDDEPHISASVAVKQSS 120
            YQNMGPQRMNVQVTQHRTDPRLTKEKLDFHEAQQKKGKPHGSRWDDEPHISASVAVKQSS
Sbjct: 61   YQNMGPQRMNVQVTQHRTDPRLTKEKLDFHEAQQKKGKPHGSRWDDEPHISASVAVKQSS 120

Query: 121  VTQVTEQSPKVQSRYTKESASSILASFGLSNEDLEELSRYPDEQLTPENMPLILRDIRMR 180
            VTQVTEQSPKVQSRYTKESASSILASFGLSNEDLEELSRYPDEQLTPENMPLILRDIRMR
Sbjct: 121  VTQVTEQSPKVQSRYTKESASSILASFGLSNEDLEELSRYPDEQLTPENMPLILRDIRMR 180

Query: 181  KMGRRLPNLPSQSRNKETLGSEAVSSNVIDYGHASKYGYTEDPLEVRIYDPEIPTDEVEN 240
            KMGRRLPNLPSQSRNKETLGSEAVSSNVIDYGHASKYGYTEDPLEVRIYDPEIPTDEVEN
Sbjct: 181  KMGRRLPNLPSQSRNKETLGSEAVSSNVIDYGHASKYGYTEDPLEVRIYDPEIPTDEVEN 240

Query: 241  EFQSQQNISASVPNPNVICNSMFPVEDVFRQMDFPGESSNNRSFFSVESGTKMSGLHISG 300
            EFQSQQNISASVPNPNVICNSMFPVEDVFRQMDFPGESSNNRSFFSVESGTKMSGLHISG
Sbjct: 241  EFQSQQNISASVPNPNVICNSMFPVEDVFRQMDFPGESSNNRSFFSVESGTKMSGLHISG 300

Query: 301  GQSVLEPIKSVNQSINQTVSQTMSQSLIPPSMNQQPFSSELISSVSQQERIPHEPVINSS 360
            GQSVLEPIKSVNQSINQTVSQTMSQSLIPPSMNQQPFSSELISSVSQQERIPHEPVINSS
Sbjct: 301  GQSVLEPIKSVNQSINQTVSQTMSQSLIPPSMNQQPFSSELISSVSQQERIPHEPVINSS 360

Query: 361  NVHVGSRGSKKNYQSQADIPIRSPFGIVKASWLPKFSHADAQKMKRLPTPSMMNDYYAAS 420
            NVHVGSRGSKKNYQSQADIPIRSPFGIVKASWLPKFSHADAQKMKRLPTPSMMNDYYAAS
Sbjct: 361  NVHVGSRGSKKNYQSQADIPIRSPFGIVKASWLPKFSHADAQKMKRLPTPSMMNDYYAAS 420

Query: 421  PRIFPHLCSLCNVECSHLKDWIQHQNTSTHIESCRQLRQQYPDWNPEILPSRRNEGNRKE 480
            PRIFPHLCSLCNVECSHLKDWIQHQNTSTHIESCRQLRQQYPDWNPEILPSRRNEGNRKE
Sbjct: 421  PRIFPHLCSLCNVECSHLKDWIQHQNTSTHIESCRQLRQQYPDWNPEILPSRRNEGNRKE 480

Query: 481  NETPRRRSHSPSPRRSRRSSSSHRFRRSRSPMHYMYRPRSRSPRICHRFISRYRSRSRSR 540
            NETPRRRSHSPSPRRSRRSSSSHRFRRSRSPMHYMYRPRSRSPRICHRFISRYRSRSRSR
Sbjct: 481  NETPRRRSHSPSPRRSRRSSSSHRFRRSRSPMHYMYRPRSRSPRICHRFISRYRSRSRSR 540

Query: 541  SPYRIRNPFRGSPKCFRSVSPERMSRRSVRSSDRKKALEDVVQRSGHGTEFNKQKHLEAA 600
            SPYRIRNPFRGSPKCFRSVSPERMSRRSVRSSDRKKALEDVVQRSGHGTEFNKQKHLEAA
Sbjct: 541  SPYRIRNPFRGSPKCFRSVSPERMSRRSVRSSDRKKALEDVVQRSGHGTEFNKQKHLEAA 600

Query: 601  DKGHSPAQKPKTSSGTKPSVKPTSATKSDSNLGGHSIRCKSKNLEDDTLSECKQVSDKAV 660
            DKGHSPAQKPKTSSGTKPSVKPTSATKSDSNLGGHSIRCKSKNLEDDTLSECKQVSDKAV
Sbjct: 601  DKGHSPAQKPKTSSGTKPSVKPTSATKSDSNLGGHSIRCKSKNLEDDTLSECKQVSDKAV 660

Query: 661  SLQRKLRKEQSLHYGSVLLITELPEDGCTEEDVRKLFQPFGKVNDVLIVPYRKEAYLEME 720
            SLQRKLRKEQSLHYGSVLLITELPEDGCTEEDVRKLFQPFGKVNDVLIVPYRKEAYLEME
Sbjct: 661  SLQRKLRKEQSLHYGSVLLITELPEDGCTEEDVRKLFQPFGKVNDVLIVPYRKEAYLEME 720

Query: 721  FKEAITAIMKYIETTPLTIKGKSVKICVPGKKKAQNKEVKKKTLESKKVSASTLKRDADA 780
            FKEAITAIMKYIETTPLTIKGKSVKICVPGKKKAQNKEVKKKTLESKKVSASTLKRDADA
Sbjct: 721  FKEAITAIMKYIETTPLTIKGKSVKICVPGKKKAQNKEVKKKTLESKKVSASTLKRDADA 780

Query: 781  SKAVEIVTSTSAAKTGQAKASVAKVNKSTGKSASSVKSVVTVAVKGNKASIKTAKSGGKK 840
            SKAVEIVTSTSAAKTGQAKASVAKVNKSTGKSASSVKSVVTVAVKGNKASIKTAKSGGKK
Sbjct: 781  SKAVEIVTSTSAAKTGQAKASVAKVNKSTGKSASSVKSVVTVAVKGNKASIKTAKSGGKK 840

Query: 841  SLEAKKTGNVKNKDSNKPVTIPENSEIKTSIEVKATENCAKEAISDAALEATENEPLNKE 900
            SLEAKKTGNVKNKDSNKPVTIPENSEIKTSIEVKATENCAKEAISDAALEATENEPLNKE
Sbjct: 841  SLEAKKTGNVKNKDSNKPVTIPENSEIKTSIEVKATENCAKEAISDAALEATENEPLNKE 900

Query: 901  TEEMCVMLVSNLPNKGYSVEEVYDLAKPFGGLKDILILSSHKKAYIEINRKAAESMVKFY 960
            TEEMCVMLVSNLPNKGYSVEEVYDLAKPFGGLKDILILSSHKKAYIEINRKAAESMVKFY
Sbjct: 901  TEEMCVMLVSNLPNKGYSVEEVYDLAKPFGGLKDILILSSHKKAYIEINRKAAESMVKFY 960

Query: 961  TCFPVLMDGNQLSISMAPENMNIKDEEAIFITLVKENDPEANIDTIYDRFVHLDNLPEDG 1020
            TCFPVLMDGNQLSISMAPENMNIKDEEAIFITLVKENDPEANIDTIYDRFVHLDNLPEDG
Sbjct: 961  TCFPVLMDGNQLSISMAPENMNIKDEEAIFITLVKENDPEANIDTIYDRFVHLDNLPEDG 1020

Query: 1021 LQCVLCVGLQFGKVDHHVFISNRNKAILQLDSPESAQSMYSFLKQNPQNIGDHMLTCSLS 1080
            LQCVLCVGLQFGKVDHHVFISNRNKAILQLDSPESAQSMYSFLKQNPQNIGDHMLTCSLS
Sbjct: 1021 LQCVLCVGLQFGKVDHHVFISNRNKAILQLDSPESAQSMYSFLKQNPQNIGDHMLTCSLS 1080

Query: 1081 PKIDLPEVQIEHDPELEKESPGLKNSPIDESEVQTATDSPSVKPNELEEESTPSIQTETL 1140
            PKIDLPEVQIEHDPELEKESPGLKNSPIDESEVQTATDSPSVKPNELEEESTPSIQTETL
Sbjct: 1081 PKIDLPEVQIEHDPELEKESPGLKNSPIDESEVQTATDSPSVKPNELEEESTPSIQTETL 1140

Query: 1141 VQQEEPCEEEAEKATCDSDFAVETLELETQGEEVKEEIPLVASASVSIEQFTENAEECAL 1200
            VQQEEPCEEEAEKATCDSDFAVETLELETQGEEVKEEIPLVASASVSIEQFTENAEECAL
Sbjct: 1141 VQQEEPCEEEAEKATCDSDFAVETLELETQGEEVKEEIPLVASASVSIEQFTENAEECAL 1200

Query: 1201 NQQMFNSDLEKKGAEIINPKTALLPSDSVFAEERNLKGILEESPSEAEDFISGITQTMVE 1260
            NQQMFNSDLEKKGAEIINPKTALLPSDSVFAEERNLKGILEESPSEAEDFISGITQTMVE
Sbjct: 1201 NQQMFNSDLEKKGAEIINPKTALLPSDSVFAEERNLKGILEESPSEAEDFISGITQTMVE 1260

Query: 1261 AVAEVEKNETVSEILPSTCIVTLVPGIPTGDEKTVDKKNISEKKGNMDEKEEKEFNTKET 1320
            AVAEVEKNETVSEILPSTCIVTLVPGIPTGDEKTVDKKNISEKKGNMDEKEEKEFNTKET
Sbjct: 1261 AVAEVEKNETVSEILPSTCIVTLVPGIPTGDEKTVDKKNISEKKGNMDEKEEKEFNTKET 1320

Query: 1321 RMDLQIGTEKAEKNEGRMDAEKVEKMAAMKEKPAENTLFKAYPNKGVGQANKPDETSKTS 1380
            RMDLQIGTEKAEKNEGRMDAEKVEKMAAMKEKPAENTLFKAYPNKGVGQANKPDETSKTS
Sbjct: 1321 RMDLQIGTEKAEKNEGRMDAEKVEKMAAMKEKPAENTLFKAYPNKGVGQANKPDETSKTS 1380

Query: 1381 ILAVSDVSSSKPSIKAVIVSSPKAKATVSKTENQKSFPKSVPRDQINAEKKLSAKEFGLL 1440
            ILAVSDVSSSKPSIKAVIVSSPKAKATVSKTENQKSFPKSVPRDQINAEKKLSAKEFGLL
Sbjct: 1381 ILAVSDVSSSKPSIKAVIVSSPKAKATVSKTENQKSFPKSVPRDQINAEKKLSAKEFGLL 1440

Query: 1441 KPTSARSGLAESSSKFKPTQSSLTRGGSGRISALQGKLSKLDYRDITKQSQETEARPSIM 1500
            KPTSARSGLAESSSKFKPTQSSLTRGGSGRISALQGKLSKLDYRDITKQSQETEARPSIM
Sbjct: 1441 KPTSARSGLAESSSKFKPTQSSLTRGGSGRISALQGKLSKLDYRDITKQSQETEARPSIM 1500

Query: 1501 KRDDSNNKTLAEQNTKNPKSTTGRSSKSKEEPLFPFNLDEFVTVDEVIEEVNPSQAKQNP 1560
            KRDDSNNKTLAEQNTKNPKSTTGRSSKSKEEPLFPFNLDEFVTVDEVIEEVNPSQAKQNP
Sbjct: 1501 KRDDSNNKTLAEQNTKNPKSTTGRSSKSKEEPLFPFNLDEFVTVDEVIEEVNPSQAKQNP 1560

Query: 1561 LKGKRKETLKNVPFSELNLKKKKGKTSTPRGVEGELSFVTLDEIGEEEDAAAHLAQALVT 1620
            LKGKRKETLKNVPFSELNLKKKKGKTSTPRGVEGELSFVTLDEIGEEEDAAAHLAQALVT
Sbjct: 1561 LKGKRKETLKNVPFSELNLKKKKGKTSTPRGVEGELSFVTLDEIGEEEDAAAHLAQALVT 1620

Query: 1621 VDEVIDEEELNMEEMVKNSNSLFTLDELIDQDDCISHSEPKDVTVLSVAEEQDLLKQERL 1680
            VDEVIDEEELNMEEMVKNSNSLFTLDELIDQDDCISHSEPKDVTVLSVAEEQDLLKQERL
Sbjct: 1621 VDEVIDEEELNMEEMVKNSNSLFTLDELIDQDDCISHSEPKDVTVLSVAEEQDLLKQERL 1680

Query: 1681 VTVDEIGEVEELPLNESADITFATLNTKGNEGDTVRDSIGFISSQVPEDPSTLVTVDEIQ 1740
            VTVDEIGEVEELPLNESADITFATLNTKGNEGDTVRDSIGFISSQVPEDPSTLVTVDEIQ
Sbjct: 1681 VTVDEIGEVEELPLNESADITFATLNTKGNEGDTVRDSIGFISSQVPEDPSTLVTVDEIQ 1740

Query: 1741 DDSSDLHLVTLDEVTEEDEDSLADFNNLKEELNFVTVDEVGEEEDGDNDLKVELAQSKND 1800
            DDSSDLHLVTLDEVTEEDEDSLADFNNLKEELNFVTVDEVGEEEDGDNDLKVELAQSKND
Sbjct: 1741 DDSSDLHLVTLDEVTEEDEDSLADFNNLKEELNFVTVDEVGEEEDGDNDLKVELAQSKND 1800

Query: 1801 HPTDKKGNRKKRAVDTKKTKLESLSQVGPVNENVMEEDLKTMIERHLTAKTPTKRVRIGK 1860
            HPTDKKGNRKKRAVDTKKTKLESLSQVGPVNENVMEEDLKTMIERHLTAKTPTKRVRIGK
Sbjct: 1801 HPTDKKGNRKKRAVDTKKTKLESLSQVGPVNENVMEEDLKTMIERHLTAKTPTKRVRIGK 1860

Query: 1861 TLPSEKAVVTEPAKGEEAFQMSEVDEESGLKDSEPERKRKKTEDSSSGKSVASDVPEELD 1920
            TLPSEKAVVTEPAKGEEAFQMSEVDEESGLKDSEPERKRKKTEDSSSGKSVASDVPEELD
Sbjct: 1861 TLPSEKAVVTEPAKGEEAFQMSEVDEESGLKDSEPERKRKKTEDSSSGKSVASDVPEELD 1920

Query: 1921 FLVPKAGFFCPICSLFYSGEKAMTNHCKSTRHKQNTEKFMAKQRKEKEQNEAEERSSR 1978
            FLVPKAGFFCPICSLFYSGEKAMTNHCKSTRHKQNTEKFMAKQRKEKEQNEAEERSSR
Sbjct: 1921 FLVPKAGFFCPICSLFYSGEKAMTNHCKSTRHKQNTEKFMAKQRKEKEQNEAEERSSR 1978


>gi|62750354 matrin 3 [Homo sapiens]
          Length = 847

 Score = 72.4 bits (176), Expect = 4e-12
 Identities = 90/400 (22%), Positives = 167/400 (41%), Gaps = 38/400 (9%)

Query: 921  EVYDLAKPFGGLKDILILSSHKKAYIEI-NRKAAESMVKFYTCFPVLMDGNQLSISMAPE 979
            ++  L +PFG + + LIL+   +A+IE+   + A++ V +YT  P L+ G  + + ++ +
Sbjct: 414  QLLQLVEPFGVISNHLILNKINEAFIEMATTEDAQAAVDYYTTTPALVFGKPVRVHLSQK 473

Query: 980  NMNIKDEEAIFITLVKENDPEANIDTIYD--RFVHLDNLPEDGL--QCVLCVGLQFGKVD 1035
               IK           E  P+   D   +  R +HL NLP  G     VL +   +GK+ 
Sbjct: 474  YKRIKK---------PEGKPDQKFDQKQELGRVIHLSNLPHSGYSDSAVLKLAEPYGKIK 524

Query: 1036 HHVFISNRNKAILQLDSPESAQSMYSFLKQNPQNIGDHMLTCSLSPKIDLPEVQI-EHDP 1094
            +++ +  +++A +++++ E A +M     +         +   LS K     ++I     
Sbjct: 525  NYILMRMKSQAFIEMETREDAMAMVDHCLKKALWFQGRCVKVDLSEKYKKLVLRIPNRGI 584

Query: 1095 ELEKESPGLKNSPIDESEVQTATDSPSVKPNELEEESTPSIQTETLVQQEEPCEEEAEKA 1154
            +L K+    K S   + +     +SPS K ++ +        TE   +QEE   E+ EK 
Sbjct: 585  DLLKKDKSRKRSYSPDGK-----ESPSDKKSKTDGSQKTESSTEG-KEQEEKSGEDGEKD 638

Query: 1155 TCDSDFAVE-TLELETQGEEVKEE----IPLVASASVSIEQFTENAEECALNQQMFNSD- 1208
            T D     E  + LE++ E + +E      L + +SV  E    N  + A + +   SD 
Sbjct: 639  TKDDQTEQEPNMLLESEDELLVDEEEAAALLESGSSVGDETDLANLGDVASDGKKEPSDK 698

Query: 1209 -LEKKGAEIINPKTALLPSDSVFAEERNLKGILEESPSEAEDFISGI----------TQT 1257
             ++K G+     K  L   D +   ++  +  LE      E+   G             T
Sbjct: 699  AVKKDGSASAAAKKKLKKVDKIEELDQENEAALENGIKNEENTEPGAESSENADDPNKDT 758

Query: 1258 MVEAVAEVEKNETVSEILPSTCIVTLVPGIPTGDEKTVDK 1297
               A  + ++N+    I     I    P +P G +  + K
Sbjct: 759  SENADGQSDENKDDYTIPDEYRIGPYQPNVPVGIDYVIPK 798



 Score = 70.5 bits (171), Expect = 2e-11
 Identities = 63/246 (25%), Positives = 107/246 (43%), Gaps = 56/246 (22%)

Query: 1781 GEEEDGDNDLKVELAQSKNDHPTDKKGNRKKRAVDTKKTKLESLSQVGP----VNEN--- 1833
            G+E   D   K + +Q K +  T+ K   +K   D +K   +  ++  P     +E+   
Sbjct: 601  GKESPSDKKSKTDGSQ-KTESSTEGKEQEEKSGEDGEKDTKDDQTEQEPNMLLESEDELL 659

Query: 1834 VMEEDLKTMIERHLTAKTPTKRVRIG------KTLPSEKAVVTEPA-------------K 1874
            V EE+   ++E   +    T    +G      K  PS+KAV  + +             K
Sbjct: 660  VDEEEAAALLESGSSVGDETDLANLGDVASDGKKEPSDKAVKKDGSASAAAKKKLKKVDK 719

Query: 1875 GEEAFQMSEVDEESGLKDSE-----------PERKRKKTEDSSSGKSVAS---------- 1913
             EE  Q +E   E+G+K+ E            +   K T +++ G+S  +          
Sbjct: 720  IEELDQENEAALENGIKNEENTEPGAESSENADDPNKDTSENADGQSDENKDDYTIPDEY 779

Query: 1914 -------DVPEELDFLVPKAGFFCPICSLFYSGEKAMTN-HCKSTRHKQNTEKFMAKQRK 1965
                   +VP  +D+++PK GF+C +CSLFY+ E+   N HC S  H Q  +KF+ K  +
Sbjct: 780  RIGPYQPNVPVGIDYVIPKTGFYCKLCSLFYTNEEVAKNTHCSSLPHYQKLKKFLNKLAE 839

Query: 1966 EKEQNE 1971
            E+ Q +
Sbjct: 840  ERRQKK 845



 Score = 64.7 bits (156), Expect = 9e-10
 Identities = 28/92 (30%), Positives = 52/92 (56%), Gaps = 5/92 (5%)

Query: 402 QKMKRLPTPSMMNDYYAASPRIFPHLCSLCNVECSHLKDWIQHQNTSTHIESCRQLRQQY 461
           +K +  P  S + D++   P+ +PHLCS+C++     K+W QH N ++H   C+ L + Y
Sbjct: 267 EKKRGAPPSSNIEDFHGLLPKGYPHLCSICDLPVHSNKEWSQHINGASHSRRCQLLLEIY 326

Query: 462 PDWNPEILPSRRNEGNRKENETPRRRSHSPSP 493
           P+WNP+      + G+   +    ++S +P+P
Sbjct: 327 PEWNPD-----NDTGHTMGDPFMLQQSTNPAP 353



 Score = 60.8 bits (146), Expect = 1e-08
 Identities = 28/50 (56%), Positives = 39/50 (78%)

Query: 132 QSRYTKESASSILASFGLSNEDLEELSRYPDEQLTPENMPLILRDIRMRK 181
           Q R   + AS+ILASFGLS  DL+ELSRYP++++TPEN+P IL  ++ R+
Sbjct: 100 QHRGDADQASNILASFGLSARDLDELSRYPEDKITPENLPQILLQLKRRR 149



 Score = 59.3 bits (142), Expect = 4e-08
 Identities = 59/272 (21%), Positives = 113/272 (41%), Gaps = 37/272 (13%)

Query: 669 EQSLHYGSVLLITELPEDGCTEEDVRKLFQPFGKVNDVLIVPYRKEAYLEMEFKEAITAI 728
           +Q    G V+ ++ LP  G ++  V KL +P+GK+ + +++  + +A++EME +E   A+
Sbjct: 489 DQKQELGRVIHLSNLPHSGYSDSAVLKLAEPYGKIKNYILMRMKSQAFIEMETREDAMAM 548

Query: 729 MKYIETTPLTIKGKSVKICVPGKKK--------------AQNKEVKKKTLESKKVSASTL 774
           + +     L  +G+ VK+ +  K K               ++K  K+      K S S  
Sbjct: 549 VDHCLKKALWFQGRCVKVDLSEKYKKLVLRIPNRGIDLLKKDKSRKRSYSPDGKESPSDK 608

Query: 775 KRDADASKAVEIVT--STSAAKTGQAKASVAKVNKS-----------------TGKSASS 815
           K   D S+  E  T       K+G+      K +++                   ++A+ 
Sbjct: 609 KSKTDGSQKTESSTEGKEQEEKSGEDGEKDTKDDQTEQEPNMLLESEDELLVDEEEAAAL 668

Query: 816 VKSVVTVAVKGNKASIKTAKSGGKK---SLEAKKTGNVKNKDSNKPVTIPENSEIKTSIE 872
           ++S  +V  + + A++    S GKK       KK G+       K   + +  E+    E
Sbjct: 669 LESGSSVGDETDLANLGDVASDGKKEPSDKAVKKDGSASAAAKKKLKKVDKIEELDQENE 728

Query: 873 VKATENCAKEAISDAALEATEN-EPLNKETEE 903
                    E  ++   E++EN +  NK+T E
Sbjct: 729 AALENGIKNEENTEPGAESSENADDPNKDTSE 760



 Score = 42.4 bits (98), Expect = 0.005
 Identities = 23/69 (33%), Positives = 43/69 (62%), Gaps = 1/69 (1%)

Query: 890 EATENEPLNKETEEMCVMLVSNLPNKGYSVEEVYDLAKPFGGLKDILILSSHKKAYIEI- 948
           E   ++  +++ E   V+ +SNLP+ GYS   V  LA+P+G +K+ +++    +A+IE+ 
Sbjct: 481 EGKPDQKFDQKQELGRVIHLSNLPHSGYSDSAVLKLAEPYGKIKNYILMRMKSQAFIEME 540

Query: 949 NRKAAESMV 957
            R+ A +MV
Sbjct: 541 TREDAMAMV 549



 Score = 40.8 bits (94), Expect = 0.013
 Identities = 22/63 (34%), Positives = 35/63 (55%)

Query: 695 KLFQPFGKVNDVLIVPYRKEAYLEMEFKEAITAIMKYIETTPLTIKGKSVKICVPGKKKA 754
           +L +PFG +++ LI+    EA++EM   E   A + Y  TTP  + GK V++ +  K K 
Sbjct: 417 QLVEPFGVISNHLILNKINEAFIEMATTEDAQAAVDYYTTTPALVFGKPVRVHLSQKYKR 476

Query: 755 QNK 757
             K
Sbjct: 477 IKK 479


>gi|21626466 matrin 3 [Homo sapiens]
          Length = 847

 Score = 72.4 bits (176), Expect = 4e-12
 Identities = 90/400 (22%), Positives = 167/400 (41%), Gaps = 38/400 (9%)

Query: 921  EVYDLAKPFGGLKDILILSSHKKAYIEI-NRKAAESMVKFYTCFPVLMDGNQLSISMAPE 979
            ++  L +PFG + + LIL+   +A+IE+   + A++ V +YT  P L+ G  + + ++ +
Sbjct: 414  QLLQLVEPFGVISNHLILNKINEAFIEMATTEDAQAAVDYYTTTPALVFGKPVRVHLSQK 473

Query: 980  NMNIKDEEAIFITLVKENDPEANIDTIYD--RFVHLDNLPEDGL--QCVLCVGLQFGKVD 1035
               IK           E  P+   D   +  R +HL NLP  G     VL +   +GK+ 
Sbjct: 474  YKRIKK---------PEGKPDQKFDQKQELGRVIHLSNLPHSGYSDSAVLKLAEPYGKIK 524

Query: 1036 HHVFISNRNKAILQLDSPESAQSMYSFLKQNPQNIGDHMLTCSLSPKIDLPEVQI-EHDP 1094
            +++ +  +++A +++++ E A +M     +         +   LS K     ++I     
Sbjct: 525  NYILMRMKSQAFIEMETREDAMAMVDHCLKKALWFQGRCVKVDLSEKYKKLVLRIPNRGI 584

Query: 1095 ELEKESPGLKNSPIDESEVQTATDSPSVKPNELEEESTPSIQTETLVQQEEPCEEEAEKA 1154
            +L K+    K S   + +     +SPS K ++ +        TE   +QEE   E+ EK 
Sbjct: 585  DLLKKDKSRKRSYSPDGK-----ESPSDKKSKTDGSQKTESSTEG-KEQEEKSGEDGEKD 638

Query: 1155 TCDSDFAVE-TLELETQGEEVKEE----IPLVASASVSIEQFTENAEECALNQQMFNSD- 1208
            T D     E  + LE++ E + +E      L + +SV  E    N  + A + +   SD 
Sbjct: 639  TKDDQTEQEPNMLLESEDELLVDEEEAAALLESGSSVGDETDLANLGDVASDGKKEPSDK 698

Query: 1209 -LEKKGAEIINPKTALLPSDSVFAEERNLKGILEESPSEAEDFISGI----------TQT 1257
             ++K G+     K  L   D +   ++  +  LE      E+   G             T
Sbjct: 699  AVKKDGSASAAAKKKLKKVDKIEELDQENEAALENGIKNEENTEPGAESSENADDPNKDT 758

Query: 1258 MVEAVAEVEKNETVSEILPSTCIVTLVPGIPTGDEKTVDK 1297
               A  + ++N+    I     I    P +P G +  + K
Sbjct: 759  SENADGQSDENKDDYTIPDEYRIGPYQPNVPVGIDYVIPK 798



 Score = 70.5 bits (171), Expect = 2e-11
 Identities = 63/246 (25%), Positives = 107/246 (43%), Gaps = 56/246 (22%)

Query: 1781 GEEEDGDNDLKVELAQSKNDHPTDKKGNRKKRAVDTKKTKLESLSQVGP----VNEN--- 1833
            G+E   D   K + +Q K +  T+ K   +K   D +K   +  ++  P     +E+   
Sbjct: 601  GKESPSDKKSKTDGSQ-KTESSTEGKEQEEKSGEDGEKDTKDDQTEQEPNMLLESEDELL 659

Query: 1834 VMEEDLKTMIERHLTAKTPTKRVRIG------KTLPSEKAVVTEPA-------------K 1874
            V EE+   ++E   +    T    +G      K  PS+KAV  + +             K
Sbjct: 660  VDEEEAAALLESGSSVGDETDLANLGDVASDGKKEPSDKAVKKDGSASAAAKKKLKKVDK 719

Query: 1875 GEEAFQMSEVDEESGLKDSE-----------PERKRKKTEDSSSGKSVAS---------- 1913
             EE  Q +E   E+G+K+ E            +   K T +++ G+S  +          
Sbjct: 720  IEELDQENEAALENGIKNEENTEPGAESSENADDPNKDTSENADGQSDENKDDYTIPDEY 779

Query: 1914 -------DVPEELDFLVPKAGFFCPICSLFYSGEKAMTN-HCKSTRHKQNTEKFMAKQRK 1965
                   +VP  +D+++PK GF+C +CSLFY+ E+   N HC S  H Q  +KF+ K  +
Sbjct: 780  RIGPYQPNVPVGIDYVIPKTGFYCKLCSLFYTNEEVAKNTHCSSLPHYQKLKKFLNKLAE 839

Query: 1966 EKEQNE 1971
            E+ Q +
Sbjct: 840  ERRQKK 845



 Score = 64.7 bits (156), Expect = 9e-10
 Identities = 28/92 (30%), Positives = 52/92 (56%), Gaps = 5/92 (5%)

Query: 402 QKMKRLPTPSMMNDYYAASPRIFPHLCSLCNVECSHLKDWIQHQNTSTHIESCRQLRQQY 461
           +K +  P  S + D++   P+ +PHLCS+C++     K+W QH N ++H   C+ L + Y
Sbjct: 267 EKKRGAPPSSNIEDFHGLLPKGYPHLCSICDLPVHSNKEWSQHINGASHSRRCQLLLEIY 326

Query: 462 PDWNPEILPSRRNEGNRKENETPRRRSHSPSP 493
           P+WNP+      + G+   +    ++S +P+P
Sbjct: 327 PEWNPD-----NDTGHTMGDPFMLQQSTNPAP 353



 Score = 60.8 bits (146), Expect = 1e-08
 Identities = 28/50 (56%), Positives = 39/50 (78%)

Query: 132 QSRYTKESASSILASFGLSNEDLEELSRYPDEQLTPENMPLILRDIRMRK 181
           Q R   + AS+ILASFGLS  DL+ELSRYP++++TPEN+P IL  ++ R+
Sbjct: 100 QHRGDADQASNILASFGLSARDLDELSRYPEDKITPENLPQILLQLKRRR 149



 Score = 59.3 bits (142), Expect = 4e-08
 Identities = 59/272 (21%), Positives = 113/272 (41%), Gaps = 37/272 (13%)

Query: 669 EQSLHYGSVLLITELPEDGCTEEDVRKLFQPFGKVNDVLIVPYRKEAYLEMEFKEAITAI 728
           +Q    G V+ ++ LP  G ++  V KL +P+GK+ + +++  + +A++EME +E   A+
Sbjct: 489 DQKQELGRVIHLSNLPHSGYSDSAVLKLAEPYGKIKNYILMRMKSQAFIEMETREDAMAM 548

Query: 729 MKYIETTPLTIKGKSVKICVPGKKK--------------AQNKEVKKKTLESKKVSASTL 774
           + +     L  +G+ VK+ +  K K               ++K  K+      K S S  
Sbjct: 549 VDHCLKKALWFQGRCVKVDLSEKYKKLVLRIPNRGIDLLKKDKSRKRSYSPDGKESPSDK 608

Query: 775 KRDADASKAVEIVT--STSAAKTGQAKASVAKVNKS-----------------TGKSASS 815
           K   D S+  E  T       K+G+      K +++                   ++A+ 
Sbjct: 609 KSKTDGSQKTESSTEGKEQEEKSGEDGEKDTKDDQTEQEPNMLLESEDELLVDEEEAAAL 668

Query: 816 VKSVVTVAVKGNKASIKTAKSGGKK---SLEAKKTGNVKNKDSNKPVTIPENSEIKTSIE 872
           ++S  +V  + + A++    S GKK       KK G+       K   + +  E+    E
Sbjct: 669 LESGSSVGDETDLANLGDVASDGKKEPSDKAVKKDGSASAAAKKKLKKVDKIEELDQENE 728

Query: 873 VKATENCAKEAISDAALEATEN-EPLNKETEE 903
                    E  ++   E++EN +  NK+T E
Sbjct: 729 AALENGIKNEENTEPGAESSENADDPNKDTSE 760



 Score = 42.4 bits (98), Expect = 0.005
 Identities = 23/69 (33%), Positives = 43/69 (62%), Gaps = 1/69 (1%)

Query: 890 EATENEPLNKETEEMCVMLVSNLPNKGYSVEEVYDLAKPFGGLKDILILSSHKKAYIEI- 948
           E   ++  +++ E   V+ +SNLP+ GYS   V  LA+P+G +K+ +++    +A+IE+ 
Sbjct: 481 EGKPDQKFDQKQELGRVIHLSNLPHSGYSDSAVLKLAEPYGKIKNYILMRMKSQAFIEME 540

Query: 949 NRKAAESMV 957
            R+ A +MV
Sbjct: 541 TREDAMAMV 549



 Score = 40.8 bits (94), Expect = 0.013
 Identities = 22/63 (34%), Positives = 35/63 (55%)

Query: 695 KLFQPFGKVNDVLIVPYRKEAYLEMEFKEAITAIMKYIETTPLTIKGKSVKICVPGKKKA 754
           +L +PFG +++ LI+    EA++EM   E   A + Y  TTP  + GK V++ +  K K 
Sbjct: 417 QLVEPFGVISNHLILNKINEAFIEMATTEDAQAAVDYYTTTPALVFGKPVRVHLSQKYKR 476

Query: 755 QNK 757
             K
Sbjct: 477 IKK 479


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 64.7 bits (156), Expect = 9e-10
 Identities = 166/913 (18%), Positives = 360/913 (39%), Gaps = 136/913 (14%)

Query: 1042 NRNKAILQLDSPESAQSMYSFLKQNPQNIGDHMLTCSLSPKIDLPEVQIEHDPE----LE 1097
            ++ +  LQ  +    +   + L+Q  + IGD         KI   E  ++   E    LE
Sbjct: 490  HQEQQALQQSTTAKLREAQNDLEQVLRQIGDK------DQKIQNLEALLQKSKENISLLE 543

Query: 1098 KESPGLKNSPIDESEVQTATDSPSVKPNELEEESTPSIQTETLVQQEEPCEEEAEKATCD 1157
            KE   L  + I   E +TA  +   + N   +E    + TE L  Q E  ++  E     
Sbjct: 544  KEREDLY-AKIQAGEGETAVLNQLQEKNHTLQEQVTQL-TEKLKNQSESHKQAQEN---- 597

Query: 1158 SDFAVETLELETQGEEVKEEIPLVASASVSIEQFTENAEECALNQQMFNSDLEKKGAEI- 1216
                     L  Q +E K  +       +S+E          LN Q+  S  +    +I 
Sbjct: 598  ---------LHDQVQEQKAHLRAAQDRVLSLETSVNE-----LNSQLNESKEKVSQLDIQ 643

Query: 1217 INPKTALLPSDSVF--AEERNLKGILEESPSEAEDFISGITQTMVEAVAEVEKNETVSEI 1274
            I  KT LL S      A+  +L+  L+ + +  +D                 K + +++I
Sbjct: 644  IKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQD-----------------KQQELNKI 686

Query: 1275 LPSTCIVTLVPGIPTGDEKTVDKK-NISEKKGNMDEKEEKEFNTKETRMDLQIGTEKAEK 1333
                  VT          K  DK+ + S+ + ++ E +EK  + ++   +L+   +K E 
Sbjct: 687  TTQLDQVTA---------KLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEA 737

Query: 1334 NEGRMDAEKVEKMAAMKEKPAENTLFKAYPNKGVGQANKPDETSKTSILAVSDVSSSKPS 1393
            +   + A K + +  ++++   NT  +    +   Q     E   ++ L +   S +  S
Sbjct: 738  DSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALES 797

Query: 1394 IKAVIVSSPKAKATVSKTENQKSFPKSVPRDQIN---------AEKKLSAKEFGLLKPTS 1444
            IK  +    + K  + +     S    +  +++N          +K    KE  + + ++
Sbjct: 798  IKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELST 857

Query: 1445 ARSGLAESSSKFKPTQSSLTRGGSGRISALQGKLSKLDYRDITKQ-------------SQ 1491
             +  L++ S   K ++S   +         +GK + LD     K+              +
Sbjct: 858  VKDKLSKVSDSLKNSKSEFEKENQ------KGKAAILDLEKTCKELKHQLQVQMENTLKE 911

Query: 1492 ETEARPSIMKRDDSNNKTLAEQNTKNPKSTTGRSS---KSKEEPLFPFNLDEFVT----- 1543
            + E + S+ K  +++++   E N+   +    +++     KEE     N++E        
Sbjct: 912  QKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQK 971

Query: 1544 ---VDEVIEEVNPSQAKQNPLKGKRKETLKNVPFSELNLKKKKGKTSTPRGVEGELSFVT 1600
               ++ +  E+  +  ++  L+ K ++ L      EL  +K+K         + + +F  
Sbjct: 972  KKQIEALQGELKIAVLQKTELENKLQQQLTQAA-QELAAEKEKISVLQNNYEKSQETFKQ 1030

Query: 1601 L--DEIGEEEDAAAHLAQALVTVDEVIDEEELNMEEMVKNSNSLFTLDELI--------- 1649
            L  D  G E +  A   Q L +V+E +    L  E+++ N N +   ++LI         
Sbjct: 1031 LQSDFYGRESELLA-TRQDLKSVEEKLS---LAQEDLISNRNQIGNQNKLIQELKTAKAT 1086

Query: 1650 -DQDDCISHSEPKD--VTVLSVAEEQDLLKQERLVTVDEIGEVEELPLNESADITFATLN 1706
             +QD      + ++    +  + +E+ L ++E +    ++ E+EE+   +  +IT     
Sbjct: 1087 LEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEE 1146

Query: 1707 TKGNEGDTV------RDSIGFISSQVPEDPSTLVTVDEIQDDSSDLHLVTLDEVTEEDED 1760
             K ++ +++      +D+   +  Q  E      ++    +       +  D+V +E+E+
Sbjct: 1147 LKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEE 1206

Query: 1761 SLADFNNLKEELNF-VTVDEVGEEEDGDNDLKVEL---AQSKNDHPTDKKGNRKKRAVDT 1816
               +F   + +L+  +   EVG ++  +N+ K+ +   A ++N     K+    +R V  
Sbjct: 1207 LKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSE 1266

Query: 1817 KKTKLESL-SQVGPVNENVM--EEDLKTMIERHLTA-----KTPTKRVRIGKTLPSEKAV 1868
             + + + L  ++  +   V   +++ + ++ER L       K  TK + + + L +  A 
Sbjct: 1267 LEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAA 1326

Query: 1869 VTEPAKGEEAFQM 1881
            V E  +  ++ Q+
Sbjct: 1327 VQELGRENQSLQI 1339


>gi|87299628 biorientation of chromosomes in cell division 1-like
            [Homo sapiens]
          Length = 3051

 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 206/1001 (20%), Positives = 369/1001 (36%), Gaps = 120/1001 (11%)

Query: 1060 YSFLKQNPQN-IGDHMLTCSLSPKIDLPEVQIEHDPELEKESPGLKNSPIDESEVQTATD 1118
            Y  L+Q   N + +H+ T + SP ++  + Q+ ++   +    G+  S ID    Q    
Sbjct: 84   YQNLRQRVDNFVANHLATHTWSPHLN--KNQLRNNIRQQVLKSGMLESGIDRIISQVVDP 141

Query: 1119 SPSVKPNELEEESTPSIQTETLVQQEEPCEEEAEKATCDSDFAVETLELETQGEEVKEEI 1178
                K N            E L       +EE    T   D   +T  L TQG       
Sbjct: 142  ----KINHTFRPQVEKAVHEFLATLNH--KEEGSGNTAPDDEKPDT-SLITQGVPTPGPS 194

Query: 1179 PLVASASVSIEQFTENAEECALNQQMFNSDLEKKGAEIINPKTALLPS-DSVFAEERNLK 1237
              VA+ ++SI +   +  + A   +        K +E  + K    P+ D+   +ER  +
Sbjct: 195  ANVANDAMSILETITSLNQEASAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSE 254

Query: 1238 GILEESPSEAEDFISGITQTMVEAVAEVEKNETVSEILPSTCIVTLVPGIPTGDEKTV-- 1295
             + ++  S A+   SG      E +    K+E  S++    C V  +          +  
Sbjct: 255  DMADKEKSTAD---SG-----GEGLETAPKSEEFSDL---PCPVEEIKNYTKEHNNLILL 303

Query: 1296 ---DKKNISEKKGNMDEKEEKEFNTKETRMDLQIGTEKAEK----NEGRMDAEKVEKMAA 1348
                ++  SE+K    +K EK+ ++ E     +   EK EK    ++   D +KV+    
Sbjct: 304  NKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQ 363

Query: 1349 MKEKPAENTLFKAYPNKGVGQANKPDETSKTSILAVSDVSSSKPSIKAVIVSSPKAKATV 1408
             KEK  E+   K    K   +A   + T +   L  SDV      I    V +    +  
Sbjct: 364  AKEKEVES--LKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGLT-DITVSSVHTSDLSSFE 420

Query: 1409 SKTENQKSFPKSVPRDQINAEKKLSAKEFGLLKPTSARSGLAESSSKF----KP-TQSSL 1463
              TE +     S+   +I ++ +   K+      TS  S     S +     KP   S  
Sbjct: 421  EDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKY 480

Query: 1464 TRGGSGRISALQGKLSKLDYRDITKQSQETEARPSIMKRDDSNNKTLAEQNTKNPKST-T 1522
                   ++  Q + S      I K+ +E   R  I +      +    + TK+ K+   
Sbjct: 481  YSDSDDELTVEQRRQS------IAKEKEERLLRRQINREKLEEKRKQKAEKTKSSKTKGQ 534

Query: 1523 GRSSKSKEEPLFPFNLDEFVTVDEVIEEVNPSQAKQNPLKGKRKETLKNVPFSELNLKKK 1582
            GRSS   EE        +   + EV++E    + K+  L  KRK+  +NV   E N KKK
Sbjct: 535  GRSSVDLEESSTKSLEPKAARIKEVLKERKVLE-KKVALSKKRKKDSRNV---EENSKKK 590

Query: 1583 KG---------KTSTPRGVEGELSFVTLDEI---GEEEDAAAHLAQALVTVDEVIDEEEL 1630
            +          KTS     E   S   L  +    E    A  L+++L  VDE  +E +L
Sbjct: 591  QQYEEDSKETLKTSEHCEKEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNESKL 650

Query: 1631 NMEEMVKNSNSLFT--LDELIDQDDCISHSEPKDVTVLSVAEEQDLLKQERLVTVD---- 1684
              E   + S  +    + E  D  D     E  ++      +++  LK E+ +  D    
Sbjct: 651  EREHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSET 710

Query: 1685 ---------EIGEVEELPLNE---SADITFATLNTKGNEGDTVRDSIGFISSQVPEDPST 1732
                     E+   +E P  E   S D        KG+      D     SS+       
Sbjct: 711  PHLKSLLKKEVKSSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELHSSE-----KG 765

Query: 1733 LVTVDEIQDDSSDLHLVTLDEVTEEDED------SLADFNNLKEELNFVTVDEVGEEEDG 1786
            L   + IQ  S    L + D+   + +       S+   +        +  DE   +E+ 
Sbjct: 766  LKVEENIQKQSQQTKLSSDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKENN 825

Query: 1787 DNDLKVELAQSKNDHPTDKKGNRK--KRAVDTKKTKLESLSQVGPVNENVMEEDLKTMIE 1844
              + ++   ++K +H + +  + K  K ++ +K+  +    +    +E+  + D   M  
Sbjct: 826  KKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDMDSTNMDS 885

Query: 1845 RHLTAKTPTKRVRIGKTLPSEKAVVTEPAK--GEEAFQMSEVDEESGLKDSEPER--KRK 1900
                 +   K  R  K+L  EK V+   +K  G++   +    +E   K +   +  K K
Sbjct: 886  NLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVETELQEGATKQATTPKPDKEK 945

Query: 1901 KTEDSSSGKSVASDVPEE------LDFLVPKAGFFC-------------PICSLFYSGEK 1941
             TE++ S K   S V ++      ++ ++  A                 P+    Y  +K
Sbjct: 946  NTEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKDSSHRAKLPLAKEKYKSDK 1005

Query: 1942 AMTN----HCKSTRHKQNTEKFMAKQRKEKEQNEAEERSSR 1978
              T+       S  HK  + K  +K  K+K++N+++++  +
Sbjct: 1006 DSTSTRLERKLSDGHKSRSLKHSSKDIKKKDENKSDDKDGK 1046



 Score = 38.5 bits (88), Expect = 0.066
 Identities = 48/194 (24%), Positives = 85/194 (43%), Gaps = 24/194 (12%)

Query: 1736 VDEIQDDSSDLHLVTLDEVTEEDEDSLADFNNLKEELNFVTVDEVGEEEDGDNDLKVELA 1795
            ++E+   SS+ +  T   + E+DE S ++    K E N    D+  + ++ D  + ++  
Sbjct: 2818 LEELPKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQND---DDTIKSQEEDQPIIIKR- 2873

Query: 1796 QSKNDHPTDKKGNRKKRAVDTK-KTKLESLSQVG--PVNENVMEEDLKTMIERHLTAKTP 1852
                     K+G  +K  V+T  K K +S +  G   V ++     LK M       +T 
Sbjct: 2874 ---------KRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETA 2924

Query: 1853 TKRVR-IGKTLPSEKAVVTEPAKGEEAFQMSEVDEESGLKDSEPERKRKKT-----EDSS 1906
              + R I      EK V +   +G +  +   V +++  + SEPERKR+K+     ED  
Sbjct: 2925 NLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDA--ESSEPERKRQKSVSDPVEDKK 2982

Query: 1907 SGKSVASDVPEELD 1920
              +S   +  EE D
Sbjct: 2983 EQESDEEEEEEEED 2996



 Score = 37.7 bits (86), Expect = 0.11
 Identities = 108/578 (18%), Positives = 204/578 (35%), Gaps = 75/578 (12%)

Query: 1091 EHDPELEKESPGLKNSPIDESEVQTATDSPSVKPNELEEE---STPSIQTETLVQQEEPC 1147
            +++ +LE+E     ++P+    VQ  TD+  VK      E     P  Q  TL  ++   
Sbjct: 645  KNESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLK 704

Query: 1148 EEEAEKATCDSDFAVETLELETQGEEVKEEIPLVASASVSIEQFTENAEECALNQQMFNS 1207
            ++++E     S    E    + + E  +E+ P     SV  +   +   +     ++ +S
Sbjct: 705  KDDSETPHLKSLLKKEVKSSKEKPE--REKTPSEDKLSVKHKYKGDCMHKTGDETELHSS 762

Query: 1208 DLEKKGAEIINPKTALLPSDSVFAEERNLKGILEESPSEAEDFISGITQTMVEAVAEVEK 1267
            +   K  E I  ++      S    ER  K   E   S        +++ +++    V K
Sbjct: 763  EKGLKVEENIQKQSQQTKLSSDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRK 822

Query: 1268 NETVSEILPSTCIVTLVPGIPTGDEKTVDKKNISEKKGNM------DEKEEKEFNTKETR 1321
                 E   S              +  + K ++  K+  +      +   E + +   T 
Sbjct: 823  ENNKKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDMDSTN 882

Query: 1322 MDLQIGTEKAEKNEGRMDAEKVEKMAAMKEKPAENTLFKAYPNKGVGQANKPDETSKTSI 1381
            MD  +  E+    E R     +E+   +K K           +K  G+  K  ET +   
Sbjct: 883  MDSNLKPEEVVHKEKRRTKSLLEEKLVLKSK-----------SKTQGKQVKVVET-ELQE 930

Query: 1382 LAVSDVSSSKPSIKAVIVSSPKAKATVSKTENQKSFPKSVPRDQINAEKKL---SAKEFG 1438
             A    ++ KP  +     +   K   SK E++       P ++   E  L   S+    
Sbjct: 931  GATKQATTPKPDKEKNTEENDSEKQRKSKVEDK-------PFEETGVEPVLETASSSAHS 983

Query: 1439 LLKPTSARSGLAESSSKFKPTQSSLTRGGSGRISALQGKLSKLDYRDITKQSQETEARPS 1498
              K +S R+ L  +  K+K  + S +       + L+ KLS        K S +   +  
Sbjct: 984  TQKDSSHRAKLPLAKEKYKSDKDSTS-------TRLERKLSDGHKSRSLKHSSKDIKKKD 1036

Query: 1499 IMKRDDSNNKTLAEQNTKNPKSTTGRSSKSKEEPLFPFNLDEFVTVDEVIEEVNPSQAKQ 1558
              K DD + K +   + K      G SS  +++            +   + E       Q
Sbjct: 1037 ENKSDDKDGKEVDSSHEK----ARGNSSLMEKK------------LSRRLCENRRGSLSQ 1080

Query: 1559 NPLKGKRK---ETLKNVPFSELNLKKKKGKTS-----TPRGVEGELSFVTLDEIGEEEDA 1610
               KG+ K    TL     S L   KK G  +      P  ++ E     + E+ + +D 
Sbjct: 1081 EMAKGEEKLAANTLSTPSGSSLQRPKKSGDMTLIPEQEPMEIDSEPGVENVFEVSKTQDN 1140

Query: 1611 AAHLAQALVTVDEVIDEEELNMEEMVKNSNSLFTLDEL 1648
              + +Q           ++++ E M + +++    DEL
Sbjct: 1141 RNNNSQ-----------QDIDSENMKQKTSATVQKDEL 1167



 Score = 31.6 bits (70), Expect = 8.1
 Identities = 48/233 (20%), Positives = 91/233 (39%), Gaps = 36/233 (15%)

Query: 1481 LDYRDITKQSQETEARPSIMKRDDSNNKTLAEQNTKNPKSTTGRSSKSKEEPLFPFNLDE 1540
            LD R  T Q Q  E  P   K ++S +     + +    STT R  + K         DE
Sbjct: 2791 LDSRIETAQRQCPETEPHDTKEENSRDLEELPKTSSETNSTTSRVMEEK---------DE 2841

Query: 1541 FVTVDEVIEEVNPSQAKQNPLKGKRKETLKNVPFSELNLKKKKGKTSTPRGVEGELSFVT 1600
            + + +   E+  P Q   + +K + ++         + +K+K+G+   PR    E +   
Sbjct: 2842 YSSSETTGEK--PEQNDDDTIKSQEED-------QPIIIKRKRGR---PRKYPVETTLKM 2889

Query: 1601 LDEIGEEEDAAAHLAQALVTVDEVIDEEELNMEEMVKNSNSLFTLDELIDQDDCISHSEP 1660
             D+        +     +VTV++     +L + +  +++     L     Q+  IS+ + 
Sbjct: 2890 KDD--------SKTDTGIVTVEQSPSSSKLKVMQTDESNKETANL-----QERSISNDDG 2936

Query: 1661 KDVTVLSVAEEQDLLKQERLVTVDEIGEVEELPLNESADITFATLNTKGNEGD 1713
            ++  V SV       K +R +TV +  E  E        ++    + K  E D
Sbjct: 2937 EEKIVTSVRRRG--RKPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESD 2987


>gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sapiens]
          Length = 1758

 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 226/1161 (19%), Positives = 411/1161 (35%), Gaps = 191/1161 (16%)

Query: 471  SRRNEGNRKENETPRRRSHSPSPRRSRRSSSSHRFRRSRSPMHYMYRPRSRSPRICHRFI 530
            S R+    +       RS+S SP   RR     R  RSRS  H  +R RSRSP       
Sbjct: 675  STRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGYHRSRSRSPP-----Y 729

Query: 531  SRYRSRSRSRSPYRIRNP-FRGSPK---------CFRSVSPE-RMSRRSVRSSDRKKALE 579
             RY SRSRS   +R ++P  R  P+          +R V P   M     RS D +   E
Sbjct: 730  RRYHSRSRSPQAFRGQSPNKRNVPQGETEREYFNRYREVPPPYDMKAYYGRSVDFRDPFE 789

Query: 580  DVVQRSGHGTEFNKQKHLEAADKGHSPAQKPKTSSGTKP-----------SVKPTSATKS 628
                R     E   ++  E   KG++   +P+ S+  +               P +  + 
Sbjct: 790  KERYRE---WERKYREWYEKYYKGYAAGAQPRPSANRENFSPERFLPLNIRNSPFTRGRR 846

Query: 629  DSNLGGHSIRCKS--------------KNLEDDTLSECKQ----VSDKAVSLQRKLRKEQ 670
            +  +GG S R ++               N +D+T S+ K+      D   +  +K RK +
Sbjct: 847  EDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRR 906

Query: 671  SLHYGSVLLITELPEDGCTEEDVRKLFQPFG----KVNDVLIVPYRKEAY-LEMEFKEAI 725
                    L  EL E        RK  +P G    K + + ++P R +A  +  E  +A 
Sbjct: 907  KGEESEGFLNPELLETS------RKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAE 960

Query: 726  TAIMKYIETTPLTIKGKSVKICVPGKKKAQNKEVKKKTLESKKVSASTLKRDADASKAVE 785
            +   K +       + K        K+K     V KK    K       K D +  ++  
Sbjct: 961  SITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPR 1020

Query: 786  IVTSTSAAKTGQAKASVAKVNKSTGK------------SASSVKSVVTVAVKGNKASIKT 833
                   AK    K    K + S+ K            S S+ +   T  VK  K     
Sbjct: 1021 SEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDY 1080

Query: 834  AKSGGKKSLEAKKTGNVKNKDSNKPVTIPENSEIKTSIEVKATENCAKEAISDAALEATE 893
            +K    + L  K+    K  + NKP+        + + E    ++    ++  + LE TE
Sbjct: 1081 SKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTE 1140

Query: 894  ------NEPLNKETEEM----------------CVMLVSNLPNKGYSVEEVYDLAKPFGG 931
                     +  +TE+M                 + L      K  S E + +  +P   
Sbjct: 1141 IVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEK 1200

Query: 932  LKDILILSSHKKAYIEINRKAAESMVKFYTCFPVLMDGNQLSISMAPENMNIKDEEAIFI 991
            L+        +K   ++ RK   +     T    L+D    S S    +   K EE    
Sbjct: 1201 LESTSSKVKQEKVKGKVRRKVTGTEGSSST----LVD--YTSTSSTGGSPVRKSEE---- 1250

Query: 992  TLVKENDPEANIDTIYDRFVHLDNLPEDGLQCVLCVGLQFGKVDHHVFISNRN--KAILQ 1049
                + D +  +    + + + +  P + +  ++ + +   K D   F S     K+   
Sbjct: 1251 ----KTDTKRTVIKTMEEYNNDNTAPAEDV--IIMIQVPQSKWDKDDFESEEEDVKSTQP 1304

Query: 1050 LDSPESAQSMYSFLKQNPQNIGDHMLTCSLSPKIDLPEVQIEHDPELEKESPGLKNSPID 1109
            + S     S+   +   P NI            +  PE + E   +++K +  + +  I 
Sbjct: 1305 ISSVGKPASVIKNVSTKPSNI------------VKYPEKESEPSEKIQKFTKDVSHE-II 1351

Query: 1110 ESEVQTATDSPSVKPNELEEESTPSIQTETLVQQEEPCEEEAEKATCDSDFAVETLELET 1169
            + EV+++ +S S +  + ++     ++ E   +++   + E E      +       L  
Sbjct: 1352 QHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQ 1411

Query: 1170 QGEEVKEEIPLVASASVSIEQFTENAEECALNQQMFNSDLEKKGAEIINPKTALLPSDSV 1229
              +E +      ++ + S + FT N ++         +D + +             S S 
Sbjct: 1412 SSKEARTSDKHDSTRASSNKDFTPNRDK--------KTDYDTREY-----------SSSK 1452

Query: 1230 FAEERNLKGILEESPSEAEDFISGITQTMVEAVAEVEKNETVSEILPSTCIVTLVPGIPT 1289
              +E+N     ++SPS  +D  SG            +KN+   E          +P   T
Sbjct: 1453 RRDEKNELTRRKDSPSRNKDSASG------------QKNKPREE--------RDLPKKGT 1492

Query: 1290 GDEKTVDKKNISEKKGNMDEKEEKEFNTKETRMDLQIGTEKAEKNEGRMDAEKVEKMAAM 1349
            GD K   K N S  +       +  ++TK    +    T+  +KN  +   + V +    
Sbjct: 1493 GDSK---KSNSSPSRDRKPHDHKATYDTKRPNEE----TKSVDKNPCKDREKHVLEARNN 1545

Query: 1350 KEKPAENTLFKAYP-------NKGVGQANKPDETSKTSILAVSDVSS--SKPSIKAVI-- 1398
            KE      L+   P        +  GQ +K     K  +   S +SS  ++ + +A    
Sbjct: 1546 KESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEP 1605

Query: 1399 ---VSSPKAKATVSKTENQKSFPKSVPRDQINAEKKLSAKEFGLLKPTSARSGLAESSSK 1455
                S  ++  +V + E+  +  K + +D+I  + K S     +++   +R+  + SS  
Sbjct: 1606 DYNESDSESNVSVKEEESSGNISKDL-KDKIVEKAKESLDTAAVVQVGISRN-QSHSSPS 1663

Query: 1456 FKPTQS-----SLTRGGSGRISALQGKLSKLDYRDITKQSQETEARPSIMKRDDSNNKTL 1510
              P++S     S TR  S   S+ + + SK   +   K+  +   +    K+       L
Sbjct: 1664 VSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVEL 1723

Query: 1511 AEQNTKNPKSTTGRSSKSKEE 1531
             +      K    + +K KE+
Sbjct: 1724 EKSQKHKHKKKKSKKNKDKEK 1744



 Score = 60.8 bits (146), Expect = 1e-08
 Identities = 187/965 (19%), Positives = 342/965 (35%), Gaps = 157/965 (16%)

Query: 466  PEILPSRRNEGNRKENETPRRRSHSPSPRRSRRSS-SSHRFRRSRSPMHYMYRP------ 518
            PE L S R+  N+K+N   + +    +P   + +    HR RR          P      
Sbjct: 865  PEKL-SARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETS 923

Query: 519  -RSRSPRICHRFISRYRSRSRSRSPYRI-RNPFRGSPKCFRSVSPERMSRRSVRSSDRKK 576
             +SR P      +   ++ S    P R    P R  P    S++ + +S +  R  D+ K
Sbjct: 924  RKSREPT----GVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPK 979

Query: 577  ALEDVVQRSGHGTEFNKQKHL---------------EAADKGHSPAQKPKTSSGTKPSVK 621
            A  D  +R   G+  +K++++               E + +   P +K K  +    + K
Sbjct: 980  AKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTK 1039

Query: 622  PTSATKSDSNLGGHSIRCKSKNLEDDTLSECKQVSDKAVSLQRKLRKEQSLHYGSVLLIT 681
             +S+++ D  + G   +  SK+ ++    E K V ++      K++K+ S    S  L T
Sbjct: 1040 SSSSSQKDEKITGTPRKAHSKSAKEH--QETKPVKEE------KVKKDYSKDVKSEKLTT 1091

Query: 682  ELPEDGCTEEDVRKLFQPFGKVNDVLIVPYRK--EAYLEMEFKEAITAIMKYIETTPLTI 739
            +       EE  +K  +    +++      RK  E  ++ +F+ +   I K +E T +  
Sbjct: 1092 K-------EEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISK-LEVTEIVK 1143

Query: 740  KGKSVKICVPGKKKAQNKEVKKKTLESKKVSASTLKRDADASKAVEIVTSTSAAKTGQAK 799
                     P +K   + E   +T E  K+S S                         A 
Sbjct: 1144 PS-------PKRKMEPDTEKMDRTPEKDKISLS-------------------------AP 1171

Query: 800  ASVAKVNKSTGKSASSVKSVVTVAVKGNKASIKTAKSGGKKSLEAKKTGNVKNKDSNKPV 859
            A   K+N+ TGK   S ++     +   K   +  +S   K  + K  G V+ K     V
Sbjct: 1172 AKKIKLNRETGKKIGSTEN-----ISNTKEPSEKLESTSSKVKQEKVKGKVRRK-----V 1221

Query: 860  TIPENSEIKTSIEVKATENCAKEAISDAALEATENEPLNKETEEM---------CVMLVS 910
            T  E S   T ++  +T +     +  +  +      + K  EE           V+++ 
Sbjct: 1222 TGTEGSS-STLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMI 1280

Query: 911  NLPNKGY-------------SVEEVYDLAKPFGGLKDILILSSHKKAYIEINRKAAESMV 957
             +P   +             S + +  + KP   +K++    S+   Y E   + +E + 
Sbjct: 1281 QVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQ 1340

Query: 958  KFYTCFP---VLMDGNQLSISMAPENMNIKDEEAIFITLVKENDPEANIDTIYDRFVHLD 1014
            KF        +  +      S + E    KD +  +  L KEN  +    T  ++  +LD
Sbjct: 1341 KFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRD--YSVLEKENPEKRKNSTQPEKESNLD 1398

Query: 1015 NLPEDGLQCVLCVGLQFGKVDHHVFISNRNKAILQLDSPES--AQSMYSFLKQNPQNIGD 1072
             L E G               +   +S  +K     D  +S  A S   F     +    
Sbjct: 1399 RLNEQG---------------NFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDY 1443

Query: 1073 HMLTCSLSPKIDLPE--VQIEHDPELEKES-PGLKNSPIDESEVQTATDSPSVKPNELEE 1129
                 S S + D      + +  P   K+S  G KN P +E ++       S K N    
Sbjct: 1444 DTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPS 1503

Query: 1130 ESTPSIQTETLVQQEEPCEE--EAEKATCDSDFAVETLELETQGEEVKEEIPLVAS---A 1184
                    +     + P EE    +K  C  D     LE     E    ++  + +    
Sbjct: 1504 RDRKPHDHKATYDTKRPNEETKSVDKNPC-KDREKHVLEARNNKESSGNKLLYILNPPET 1562

Query: 1185 SVSIEQFTENAEECALNQQMFNSDLEKKGAEII--NPKTALLPSDSVFAEERNLKGILEE 1242
             V  EQ T   ++  +  +   S   +  +++     + A  P  +    E N+    EE
Sbjct: 1563 QVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEE 1622

Query: 1243 S----PSEAEDFISGITQTMVEAVAEVEKNETVSEILPSTCIVTLVPGIPTGDEKTVDKK 1298
            S      + +D I    +  ++  A V+   + ++   S  +       P+G +      
Sbjct: 1623 SSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSS 1682

Query: 1299 NI-------SEKKGNMDEKEEKEFNTKETRMDLQIGTE-KAEKNEGRMDAEKVEKMAAMK 1350
            +        S+KK    EK++ + + K  +     GTE + EK++     +K  K    K
Sbjct: 1683 SASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDK 1742

Query: 1351 EKPAE 1355
            EK  E
Sbjct: 1743 EKEKE 1747



 Score = 54.7 bits (130), Expect = 9e-07
 Identities = 147/735 (20%), Positives = 268/735 (36%), Gaps = 86/735 (11%)

Query: 1285 PGIPTGDEKTVDKKNISEKKGNMDEKEEKEFNT---------KETRMDLQIGTEKAEKNE 1335
            P I    E+T   K  + K  +  +K+EK   T         KE +    +  EK +K+ 
Sbjct: 1023 PPIKKAKEET--PKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDY 1080

Query: 1336 GR-MDAEKVEKMAAMKEKPAENTLFKAYPNKGVGQANKPDETSKTSILAVSDVSSSKPSI 1394
             + + +EK+       +KP E    K   NKG  +  K +E         S +  SK  +
Sbjct: 1081 SKDVKSEKLTTKEEKAKKPNEKN--KPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEV 1138

Query: 1395 KAVIVSSPKAK-----ATVSKTENQKSFPKSVPRDQINAEKKLSAKEFGLLKPTSARSGL 1449
              ++  SPK K       + +T  +     S P  +I   ++   K    +  T   S  
Sbjct: 1139 TEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKK----IGSTENISNT 1194

Query: 1450 AESSSKFKPTQSSL----TRGGSGR-ISALQGKLSKLDYRDITKQSQETEARPSIMKRDD 1504
             E S K + T S +     +G   R ++  +G  S L     T  +  +  R S  K D 
Sbjct: 1195 KEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDT 1254

Query: 1505 SNN--KTLAEQNTKNPKSTTGRSSKSKEEPLFPFNLDEFVTVDEVIEEVNPSQAKQNPLK 1562
                 KT+ E N  N            + P   ++ D+F + +E ++   P  +      
Sbjct: 1255 KRTVIKTMEEYNNDNTAPAEDVIIMI-QVPQSKWDKDDFESEEEDVKSTQPISS-----V 1308

Query: 1563 GKRKETLKNVPFSELNLKKKKGKTSTP-RGVEGELSFVTLDEIGEEEDAAAHLAQALVTV 1621
            GK    +KNV     N+ K   K S P   ++     V+ + I  E  ++ + A +    
Sbjct: 1309 GKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGK 1368

Query: 1622 DEVIDEEELNMEEMVKNSNSLFTLDELIDQDDCISHSEPKDVTVLSVAEEQDLLKQERLV 1681
             +  D   L  E   K  NS                ++P+  + L    EQ   K     
Sbjct: 1369 TKDRDYSVLEKENPEKRKNS----------------TQPEKESNLDRLNEQGNFKSLSQS 1412

Query: 1682 TVDEIGEVEELPLNESADITFATLN---TKGNEGDTVRDSIGFISSQVPEDPSTLVTVDE 1738
            +       +E   ++  D T A+ N   T   +  T  D+  + SS+  ++ + L    +
Sbjct: 1413 S-------KEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKD 1465

Query: 1739 IQDDSSDLHLVTLDEVTEEDEDSLADFNNLKEELNFVTVDEVGEEEDGDNDLKVELAQSK 1798
                + D      ++  EE +       + K+  +  + D    +     D K    ++K
Sbjct: 1466 SPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETK 1525

Query: 1799 NDHPTDKKGNRKKRAVDTKKTKLES----LSQVGPVNENVMEEDLKTMIERHLTAKTPTK 1854
            +      K +R+K  ++ +  K  S    L  + P    V +E +   I++  +   P  
Sbjct: 1526 SVDKNPCK-DREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDK--STVKPKP 1582

Query: 1855 RVRIGKTLPSEKAVVTEPAKGEEAFQMSEVDEESGLKDSEPERKRKKTEDSSSGKSVASD 1914
            ++     L S+    T+ A  E  +  +E D ES +   E E     ++D      +   
Sbjct: 1583 QLSHSSRLSSDLTRETDEAAFEPDY--NESDSESNVSVKEEESSGNISKDLKD--KIVEK 1638

Query: 1915 VPEELD-FLVPKAGF----------FCPICSLFYSGEKAMTNHCKSTRHKQNTEKFMAKQ 1963
              E LD   V + G             P  S   SG +   +H  S    ++ +    K+
Sbjct: 1639 AKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQT-RSHSSSASSAESQDSKKKKK 1697

Query: 1964 RKEKEQNEAEERSSR 1978
            +KEK++++  ++  +
Sbjct: 1698 KKEKKKHKKHKKHKK 1712



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 97/416 (23%), Positives = 152/416 (36%), Gaps = 97/416 (23%)

Query: 1265 VEKNETVSE-ILPSTCIVTLVPGIPTGDEKTVDKKNISEKKGNMDEKEEKEFNTKETRMD 1323
            VE+N+T S  +LPS    T V   P  D +++  K++SEK    D++E  +   K     
Sbjct: 932  VEENKTDSLFVLPSRDDATPVRDEPM-DAESITFKSVSEK----DKRERDKPKAK----- 981

Query: 1324 LQIGTEKAEKNEGRMDAEKVEKMAAMKEKPAENTLFKAYPNKGVGQANKPDETSKTSILA 1383
               G +   KN+G   ++K   +     KPA+            G   K D   + S   
Sbjct: 982  ---GDKTKRKNDGSAVSKKENIV-----KPAK------------GPQEKVDGERERS--- 1018

Query: 1384 VSDVSSSKPSIKAVIVSSPKAKATVSKTENQ----------KSFPKSVPRDQ----INAE 1429
                  S+P IK     +PK   T S + +Q          K+  KS    Q    +  E
Sbjct: 1019 ----PRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEE 1074

Query: 1430 K------------KLSAKEFGLLKPTSARSGLAESSSKFKPTQSSLTRGGSGRISALQGK 1477
            K            KL+ KE    KP      L     K K  + +  +G      +   K
Sbjct: 1075 KVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRK--RKTEEKGVDKDFESSSMK 1132

Query: 1478 LSKLDYRDITKQSQETEARPSIMKRDDSNNKTLAEQNTKNPK----STTGRSSKSKEEPL 1533
            +SKL+  +I K S + +  P   K D +  K     +    K      TG+   S E   
Sbjct: 1133 ISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTE--- 1189

Query: 1534 FPFNLDEFVTVDEVIEEVNPSQAKQNPLKGKRKETLKNVPFSELNL-------------- 1579
               N+       E +E  + S+ KQ  +KGK +  +     S   L              
Sbjct: 1190 ---NISNTKEPSEKLESTS-SKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPV 1245

Query: 1580 KKKKGKTSTPRGVEGELSFVTLDEIGEEEDAAAHLAQALVTVDE-VIDEEELNMEE 1634
            +K + KT T R V       T++E   +  A A     ++ V +   D+++   EE
Sbjct: 1246 RKSEEKTDTKRTV-----IKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEE 1296



 Score = 39.7 bits (91), Expect = 0.030
 Identities = 107/614 (17%), Positives = 215/614 (35%), Gaps = 102/614 (16%)

Query: 94   QKKGKPHGSRWDDEPHISASVAVKQSSVTQVTEQSPKVQSRYTKESASSILASFGLSNED 153
            +K+ +    +  D+   S+S+ + +  VT++ + SPK +                    D
Sbjct: 1111 EKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRK-----------------MEPD 1153

Query: 154  LEELSRYPDEQLTPENMPLILRDIRM-RKMGRRLPNLPSQSRNKE--------------- 197
             E++ R P++     + P   + I++ R+ G+++ +  + S  KE               
Sbjct: 1154 TEKMDRTPEKDKISLSAP--AKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQE 1211

Query: 198  ---------TLGSEAVSSNVIDYGHASKYGYTEDPLEVRIYDPEIPTDEVENEFQSQQNI 248
                       G+E  SS ++DY   S  G +             P  + E +  +++ +
Sbjct: 1212 KVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGS-------------PVRKSEEKTDTKRTV 1258

Query: 249  SASVPNPNVICNSMFPVEDVFRQMDFPGESSNNRSFFSVESGTKMSGLHISGGQSVLEPI 308
              ++   N   ++  P EDV   +  P    +   F S E   K +           +PI
Sbjct: 1259 IKTMEEYN--NDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKST-----------QPI 1305

Query: 309  KSVNQ--SINQTVSQTMSQSLIPPSMNQQPFSSELISSVSQQERIPHEPVINSSNVHVGS 366
             SV +  S+ + VS   S  +  P    +P  SE I   ++   + HE + +       S
Sbjct: 1306 SSVGKPASVIKNVSTKPSNIVKYPEKESEP--SEKIQKFTKD--VSHEIIQHEVKSSKNS 1361

Query: 367  RGSKKNYQSQADIPIRSPFGIVKASWLPKFSHADAQKMKRLPTPSMMNDYYAASPRIFPH 426
              S+K      D  +     + K +   + +    +K   L   +   ++ + S      
Sbjct: 1362 ASSEKGKTKDRDYSV-----LEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEA 1416

Query: 427  LCS--LCNVECSHLKDWIQHQNTSTHIESCRQLRQQYPDWNPEIL-----PSRRNEGNRK 479
              S    +   S  KD+  +++  T  ++      +  D   E+      PSR  +    
Sbjct: 1417 RTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASG 1476

Query: 480  ENETPRRRSHSPSPRRSRRSSSSHRFRRSRSPMHYMYRPRSRSPRICHRFISRYRSRSRS 539
            +   PR     P         S+    R R P  +     ++ P    + + +   + R 
Sbjct: 1477 QKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDRE 1536

Query: 540  RSPYRIRN--PFRGSPKCFRSVSPERMSRRSVRSSDRKKALEDVVQRSGHGTEFNKQKHL 597
            +     RN     G+   +    PE    +   +    K+      +  H +  +     
Sbjct: 1537 KHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTR 1596

Query: 598  EAADKGHSPAQKPKTSSGTKPSVKPTSATKSDSNLGGHSIRCKSKNLEDDTLSECKQVSD 657
            E  +    P    ++ S +  SVK     +S  N+        SK+L+D  + + K+  D
Sbjct: 1597 ETDEAAFEPDYN-ESDSESNVSVK---EEESSGNI--------SKDLKDKIVEKAKESLD 1644

Query: 658  KAVSLQRKLRKEQS 671
             A  +Q  + + QS
Sbjct: 1645 TAAVVQVGISRNQS 1658


>gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sapiens]
          Length = 1792

 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 226/1161 (19%), Positives = 411/1161 (35%), Gaps = 191/1161 (16%)

Query: 471  SRRNEGNRKENETPRRRSHSPSPRRSRRSSSSHRFRRSRSPMHYMYRPRSRSPRICHRFI 530
            S R+    +       RS+S SP   RR     R  RSRS  H  +R RSRSP       
Sbjct: 709  STRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGYHRSRSRSPP-----Y 763

Query: 531  SRYRSRSRSRSPYRIRNP-FRGSPK---------CFRSVSPE-RMSRRSVRSSDRKKALE 579
             RY SRSRS   +R ++P  R  P+          +R V P   M     RS D +   E
Sbjct: 764  RRYHSRSRSPQAFRGQSPNKRNVPQGETEREYFNRYREVPPPYDMKAYYGRSVDFRDPFE 823

Query: 580  DVVQRSGHGTEFNKQKHLEAADKGHSPAQKPKTSSGTKP-----------SVKPTSATKS 628
                R     E   ++  E   KG++   +P+ S+  +               P +  + 
Sbjct: 824  KERYRE---WERKYREWYEKYYKGYAAGAQPRPSANRENFSPERFLPLNIRNSPFTRGRR 880

Query: 629  DSNLGGHSIRCKS--------------KNLEDDTLSECKQ----VSDKAVSLQRKLRKEQ 670
            +  +GG S R ++               N +D+T S+ K+      D   +  +K RK +
Sbjct: 881  EDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRR 940

Query: 671  SLHYGSVLLITELPEDGCTEEDVRKLFQPFG----KVNDVLIVPYRKEAY-LEMEFKEAI 725
                    L  EL E        RK  +P G    K + + ++P R +A  +  E  +A 
Sbjct: 941  KGEESEGFLNPELLETS------RKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAE 994

Query: 726  TAIMKYIETTPLTIKGKSVKICVPGKKKAQNKEVKKKTLESKKVSASTLKRDADASKAVE 785
            +   K +       + K        K+K     V KK    K       K D +  ++  
Sbjct: 995  SITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPR 1054

Query: 786  IVTSTSAAKTGQAKASVAKVNKSTGK------------SASSVKSVVTVAVKGNKASIKT 833
                   AK    K    K + S+ K            S S+ +   T  VK  K     
Sbjct: 1055 SEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDY 1114

Query: 834  AKSGGKKSLEAKKTGNVKNKDSNKPVTIPENSEIKTSIEVKATENCAKEAISDAALEATE 893
            +K    + L  K+    K  + NKP+        + + E    ++    ++  + LE TE
Sbjct: 1115 SKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTE 1174

Query: 894  ------NEPLNKETEEM----------------CVMLVSNLPNKGYSVEEVYDLAKPFGG 931
                     +  +TE+M                 + L      K  S E + +  +P   
Sbjct: 1175 IVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEK 1234

Query: 932  LKDILILSSHKKAYIEINRKAAESMVKFYTCFPVLMDGNQLSISMAPENMNIKDEEAIFI 991
            L+        +K   ++ RK   +     T    L+D    S S    +   K EE    
Sbjct: 1235 LESTSSKVKQEKVKGKVRRKVTGTEGSSST----LVD--YTSTSSTGGSPVRKSEE---- 1284

Query: 992  TLVKENDPEANIDTIYDRFVHLDNLPEDGLQCVLCVGLQFGKVDHHVFISNRN--KAILQ 1049
                + D +  +    + + + +  P + +  ++ + +   K D   F S     K+   
Sbjct: 1285 ----KTDTKRTVIKTMEEYNNDNTAPAEDV--IIMIQVPQSKWDKDDFESEEEDVKSTQP 1338

Query: 1050 LDSPESAQSMYSFLKQNPQNIGDHMLTCSLSPKIDLPEVQIEHDPELEKESPGLKNSPID 1109
            + S     S+   +   P NI            +  PE + E   +++K +  + +  I 
Sbjct: 1339 ISSVGKPASVIKNVSTKPSNI------------VKYPEKESEPSEKIQKFTKDVSHE-II 1385

Query: 1110 ESEVQTATDSPSVKPNELEEESTPSIQTETLVQQEEPCEEEAEKATCDSDFAVETLELET 1169
            + EV+++ +S S +  + ++     ++ E   +++   + E E      +       L  
Sbjct: 1386 QHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQ 1445

Query: 1170 QGEEVKEEIPLVASASVSIEQFTENAEECALNQQMFNSDLEKKGAEIINPKTALLPSDSV 1229
              +E +      ++ + S + FT N ++         +D + +             S S 
Sbjct: 1446 SSKEARTSDKHDSTRASSNKDFTPNRDK--------KTDYDTREY-----------SSSK 1486

Query: 1230 FAEERNLKGILEESPSEAEDFISGITQTMVEAVAEVEKNETVSEILPSTCIVTLVPGIPT 1289
              +E+N     ++SPS  +D  SG            +KN+   E          +P   T
Sbjct: 1487 RRDEKNELTRRKDSPSRNKDSASG------------QKNKPREE--------RDLPKKGT 1526

Query: 1290 GDEKTVDKKNISEKKGNMDEKEEKEFNTKETRMDLQIGTEKAEKNEGRMDAEKVEKMAAM 1349
            GD K   K N S  +       +  ++TK    +    T+  +KN  +   + V +    
Sbjct: 1527 GDSK---KSNSSPSRDRKPHDHKATYDTKRPNEE----TKSVDKNPCKDREKHVLEARNN 1579

Query: 1350 KEKPAENTLFKAYP-------NKGVGQANKPDETSKTSILAVSDVSS--SKPSIKAVI-- 1398
            KE      L+   P        +  GQ +K     K  +   S +SS  ++ + +A    
Sbjct: 1580 KESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEP 1639

Query: 1399 ---VSSPKAKATVSKTENQKSFPKSVPRDQINAEKKLSAKEFGLLKPTSARSGLAESSSK 1455
                S  ++  +V + E+  +  K + +D+I  + K S     +++   +R+  + SS  
Sbjct: 1640 DYNESDSESNVSVKEEESSGNISKDL-KDKIVEKAKESLDTAAVVQVGISRN-QSHSSPS 1697

Query: 1456 FKPTQS-----SLTRGGSGRISALQGKLSKLDYRDITKQSQETEARPSIMKRDDSNNKTL 1510
              P++S     S TR  S   S+ + + SK   +   K+  +   +    K+       L
Sbjct: 1698 VSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVEL 1757

Query: 1511 AEQNTKNPKSTTGRSSKSKEE 1531
             +      K    + +K KE+
Sbjct: 1758 EKSQKHKHKKKKSKKNKDKEK 1778



 Score = 60.8 bits (146), Expect = 1e-08
 Identities = 187/965 (19%), Positives = 342/965 (35%), Gaps = 157/965 (16%)

Query: 466  PEILPSRRNEGNRKENETPRRRSHSPSPRRSRRSS-SSHRFRRSRSPMHYMYRP------ 518
            PE L S R+  N+K+N   + +    +P   + +    HR RR          P      
Sbjct: 899  PEKL-SARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETS 957

Query: 519  -RSRSPRICHRFISRYRSRSRSRSPYRI-RNPFRGSPKCFRSVSPERMSRRSVRSSDRKK 576
             +SR P      +   ++ S    P R    P R  P    S++ + +S +  R  D+ K
Sbjct: 958  RKSREPT----GVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPK 1013

Query: 577  ALEDVVQRSGHGTEFNKQKHL---------------EAADKGHSPAQKPKTSSGTKPSVK 621
            A  D  +R   G+  +K++++               E + +   P +K K  +    + K
Sbjct: 1014 AKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTK 1073

Query: 622  PTSATKSDSNLGGHSIRCKSKNLEDDTLSECKQVSDKAVSLQRKLRKEQSLHYGSVLLIT 681
             +S+++ D  + G   +  SK+ ++    E K V ++      K++K+ S    S  L T
Sbjct: 1074 SSSSSQKDEKITGTPRKAHSKSAKEH--QETKPVKEE------KVKKDYSKDVKSEKLTT 1125

Query: 682  ELPEDGCTEEDVRKLFQPFGKVNDVLIVPYRK--EAYLEMEFKEAITAIMKYIETTPLTI 739
            +       EE  +K  +    +++      RK  E  ++ +F+ +   I K +E T +  
Sbjct: 1126 K-------EEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISK-LEVTEIVK 1177

Query: 740  KGKSVKICVPGKKKAQNKEVKKKTLESKKVSASTLKRDADASKAVEIVTSTSAAKTGQAK 799
                     P +K   + E   +T E  K+S S                         A 
Sbjct: 1178 PS-------PKRKMEPDTEKMDRTPEKDKISLS-------------------------AP 1205

Query: 800  ASVAKVNKSTGKSASSVKSVVTVAVKGNKASIKTAKSGGKKSLEAKKTGNVKNKDSNKPV 859
            A   K+N+ TGK   S ++     +   K   +  +S   K  + K  G V+ K     V
Sbjct: 1206 AKKIKLNRETGKKIGSTEN-----ISNTKEPSEKLESTSSKVKQEKVKGKVRRK-----V 1255

Query: 860  TIPENSEIKTSIEVKATENCAKEAISDAALEATENEPLNKETEEM---------CVMLVS 910
            T  E S   T ++  +T +     +  +  +      + K  EE           V+++ 
Sbjct: 1256 TGTEGSS-STLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMI 1314

Query: 911  NLPNKGY-------------SVEEVYDLAKPFGGLKDILILSSHKKAYIEINRKAAESMV 957
             +P   +             S + +  + KP   +K++    S+   Y E   + +E + 
Sbjct: 1315 QVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQ 1374

Query: 958  KFYTCFP---VLMDGNQLSISMAPENMNIKDEEAIFITLVKENDPEANIDTIYDRFVHLD 1014
            KF        +  +      S + E    KD +  +  L KEN  +    T  ++  +LD
Sbjct: 1375 KFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRD--YSVLEKENPEKRKNSTQPEKESNLD 1432

Query: 1015 NLPEDGLQCVLCVGLQFGKVDHHVFISNRNKAILQLDSPES--AQSMYSFLKQNPQNIGD 1072
             L E G               +   +S  +K     D  +S  A S   F     +    
Sbjct: 1433 RLNEQG---------------NFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDY 1477

Query: 1073 HMLTCSLSPKIDLPE--VQIEHDPELEKES-PGLKNSPIDESEVQTATDSPSVKPNELEE 1129
                 S S + D      + +  P   K+S  G KN P +E ++       S K N    
Sbjct: 1478 DTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPS 1537

Query: 1130 ESTPSIQTETLVQQEEPCEE--EAEKATCDSDFAVETLELETQGEEVKEEIPLVAS---A 1184
                    +     + P EE    +K  C  D     LE     E    ++  + +    
Sbjct: 1538 RDRKPHDHKATYDTKRPNEETKSVDKNPC-KDREKHVLEARNNKESSGNKLLYILNPPET 1596

Query: 1185 SVSIEQFTENAEECALNQQMFNSDLEKKGAEII--NPKTALLPSDSVFAEERNLKGILEE 1242
             V  EQ T   ++  +  +   S   +  +++     + A  P  +    E N+    EE
Sbjct: 1597 QVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEE 1656

Query: 1243 S----PSEAEDFISGITQTMVEAVAEVEKNETVSEILPSTCIVTLVPGIPTGDEKTVDKK 1298
            S      + +D I    +  ++  A V+   + ++   S  +       P+G +      
Sbjct: 1657 SSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSS 1716

Query: 1299 NI-------SEKKGNMDEKEEKEFNTKETRMDLQIGTE-KAEKNEGRMDAEKVEKMAAMK 1350
            +        S+KK    EK++ + + K  +     GTE + EK++     +K  K    K
Sbjct: 1717 SASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDK 1776

Query: 1351 EKPAE 1355
            EK  E
Sbjct: 1777 EKEKE 1781



 Score = 54.7 bits (130), Expect = 9e-07
 Identities = 147/735 (20%), Positives = 268/735 (36%), Gaps = 86/735 (11%)

Query: 1285 PGIPTGDEKTVDKKNISEKKGNMDEKEEKEFNT---------KETRMDLQIGTEKAEKNE 1335
            P I    E+T   K  + K  +  +K+EK   T         KE +    +  EK +K+ 
Sbjct: 1057 PPIKKAKEET--PKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDY 1114

Query: 1336 GR-MDAEKVEKMAAMKEKPAENTLFKAYPNKGVGQANKPDETSKTSILAVSDVSSSKPSI 1394
             + + +EK+       +KP E    K   NKG  +  K +E         S +  SK  +
Sbjct: 1115 SKDVKSEKLTTKEEKAKKPNEKN--KPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEV 1172

Query: 1395 KAVIVSSPKAK-----ATVSKTENQKSFPKSVPRDQINAEKKLSAKEFGLLKPTSARSGL 1449
              ++  SPK K       + +T  +     S P  +I   ++   K    +  T   S  
Sbjct: 1173 TEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKK----IGSTENISNT 1228

Query: 1450 AESSSKFKPTQSSL----TRGGSGR-ISALQGKLSKLDYRDITKQSQETEARPSIMKRDD 1504
             E S K + T S +     +G   R ++  +G  S L     T  +  +  R S  K D 
Sbjct: 1229 KEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDT 1288

Query: 1505 SNN--KTLAEQNTKNPKSTTGRSSKSKEEPLFPFNLDEFVTVDEVIEEVNPSQAKQNPLK 1562
                 KT+ E N  N            + P   ++ D+F + +E ++   P  +      
Sbjct: 1289 KRTVIKTMEEYNNDNTAPAEDVIIMI-QVPQSKWDKDDFESEEEDVKSTQPISS-----V 1342

Query: 1563 GKRKETLKNVPFSELNLKKKKGKTSTP-RGVEGELSFVTLDEIGEEEDAAAHLAQALVTV 1621
            GK    +KNV     N+ K   K S P   ++     V+ + I  E  ++ + A +    
Sbjct: 1343 GKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGK 1402

Query: 1622 DEVIDEEELNMEEMVKNSNSLFTLDELIDQDDCISHSEPKDVTVLSVAEEQDLLKQERLV 1681
             +  D   L  E   K  NS                ++P+  + L    EQ   K     
Sbjct: 1403 TKDRDYSVLEKENPEKRKNS----------------TQPEKESNLDRLNEQGNFKSLSQS 1446

Query: 1682 TVDEIGEVEELPLNESADITFATLN---TKGNEGDTVRDSIGFISSQVPEDPSTLVTVDE 1738
            +       +E   ++  D T A+ N   T   +  T  D+  + SS+  ++ + L    +
Sbjct: 1447 S-------KEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKD 1499

Query: 1739 IQDDSSDLHLVTLDEVTEEDEDSLADFNNLKEELNFVTVDEVGEEEDGDNDLKVELAQSK 1798
                + D      ++  EE +       + K+  +  + D    +     D K    ++K
Sbjct: 1500 SPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETK 1559

Query: 1799 NDHPTDKKGNRKKRAVDTKKTKLES----LSQVGPVNENVMEEDLKTMIERHLTAKTPTK 1854
            +      K +R+K  ++ +  K  S    L  + P    V +E +   I++  +   P  
Sbjct: 1560 SVDKNPCK-DREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDK--STVKPKP 1616

Query: 1855 RVRIGKTLPSEKAVVTEPAKGEEAFQMSEVDEESGLKDSEPERKRKKTEDSSSGKSVASD 1914
            ++     L S+    T+ A  E  +  +E D ES +   E E     ++D      +   
Sbjct: 1617 QLSHSSRLSSDLTRETDEAAFEPDY--NESDSESNVSVKEEESSGNISKDLKD--KIVEK 1672

Query: 1915 VPEELD-FLVPKAGF----------FCPICSLFYSGEKAMTNHCKSTRHKQNTEKFMAKQ 1963
              E LD   V + G             P  S   SG +   +H  S    ++ +    K+
Sbjct: 1673 AKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQT-RSHSSSASSAESQDSKKKKK 1731

Query: 1964 RKEKEQNEAEERSSR 1978
            +KEK++++  ++  +
Sbjct: 1732 KKEKKKHKKHKKHKK 1746



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 97/416 (23%), Positives = 152/416 (36%), Gaps = 97/416 (23%)

Query: 1265 VEKNETVSE-ILPSTCIVTLVPGIPTGDEKTVDKKNISEKKGNMDEKEEKEFNTKETRMD 1323
            VE+N+T S  +LPS    T V   P  D +++  K++SEK    D++E  +   K     
Sbjct: 966  VEENKTDSLFVLPSRDDATPVRDEPM-DAESITFKSVSEK----DKRERDKPKAK----- 1015

Query: 1324 LQIGTEKAEKNEGRMDAEKVEKMAAMKEKPAENTLFKAYPNKGVGQANKPDETSKTSILA 1383
               G +   KN+G   ++K   +     KPA+            G   K D   + S   
Sbjct: 1016 ---GDKTKRKNDGSAVSKKENIV-----KPAK------------GPQEKVDGERERS--- 1052

Query: 1384 VSDVSSSKPSIKAVIVSSPKAKATVSKTENQ----------KSFPKSVPRDQ----INAE 1429
                  S+P IK     +PK   T S + +Q          K+  KS    Q    +  E
Sbjct: 1053 ----PRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEE 1108

Query: 1430 K------------KLSAKEFGLLKPTSARSGLAESSSKFKPTQSSLTRGGSGRISALQGK 1477
            K            KL+ KE    KP      L     K K  + +  +G      +   K
Sbjct: 1109 KVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRK--RKTEEKGVDKDFESSSMK 1166

Query: 1478 LSKLDYRDITKQSQETEARPSIMKRDDSNNKTLAEQNTKNPK----STTGRSSKSKEEPL 1533
            +SKL+  +I K S + +  P   K D +  K     +    K      TG+   S E   
Sbjct: 1167 ISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTE--- 1223

Query: 1534 FPFNLDEFVTVDEVIEEVNPSQAKQNPLKGKRKETLKNVPFSELNL-------------- 1579
               N+       E +E  + S+ KQ  +KGK +  +     S   L              
Sbjct: 1224 ---NISNTKEPSEKLESTS-SKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPV 1279

Query: 1580 KKKKGKTSTPRGVEGELSFVTLDEIGEEEDAAAHLAQALVTVDE-VIDEEELNMEE 1634
            +K + KT T R V       T++E   +  A A     ++ V +   D+++   EE
Sbjct: 1280 RKSEEKTDTKRTV-----IKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEE 1330



 Score = 39.7 bits (91), Expect = 0.030
 Identities = 107/614 (17%), Positives = 215/614 (35%), Gaps = 102/614 (16%)

Query: 94   QKKGKPHGSRWDDEPHISASVAVKQSSVTQVTEQSPKVQSRYTKESASSILASFGLSNED 153
            +K+ +    +  D+   S+S+ + +  VT++ + SPK +                    D
Sbjct: 1145 EKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRK-----------------MEPD 1187

Query: 154  LEELSRYPDEQLTPENMPLILRDIRM-RKMGRRLPNLPSQSRNKE--------------- 197
             E++ R P++     + P   + I++ R+ G+++ +  + S  KE               
Sbjct: 1188 TEKMDRTPEKDKISLSAP--AKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQE 1245

Query: 198  ---------TLGSEAVSSNVIDYGHASKYGYTEDPLEVRIYDPEIPTDEVENEFQSQQNI 248
                       G+E  SS ++DY   S  G +             P  + E +  +++ +
Sbjct: 1246 KVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGS-------------PVRKSEEKTDTKRTV 1292

Query: 249  SASVPNPNVICNSMFPVEDVFRQMDFPGESSNNRSFFSVESGTKMSGLHISGGQSVLEPI 308
              ++   N   ++  P EDV   +  P    +   F S E   K +           +PI
Sbjct: 1293 IKTMEEYN--NDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKST-----------QPI 1339

Query: 309  KSVNQ--SINQTVSQTMSQSLIPPSMNQQPFSSELISSVSQQERIPHEPVINSSNVHVGS 366
             SV +  S+ + VS   S  +  P    +P  SE I   ++   + HE + +       S
Sbjct: 1340 SSVGKPASVIKNVSTKPSNIVKYPEKESEP--SEKIQKFTKD--VSHEIIQHEVKSSKNS 1395

Query: 367  RGSKKNYQSQADIPIRSPFGIVKASWLPKFSHADAQKMKRLPTPSMMNDYYAASPRIFPH 426
              S+K      D  +     + K +   + +    +K   L   +   ++ + S      
Sbjct: 1396 ASSEKGKTKDRDYSV-----LEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEA 1450

Query: 427  LCS--LCNVECSHLKDWIQHQNTSTHIESCRQLRQQYPDWNPEIL-----PSRRNEGNRK 479
              S    +   S  KD+  +++  T  ++      +  D   E+      PSR  +    
Sbjct: 1451 RTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASG 1510

Query: 480  ENETPRRRSHSPSPRRSRRSSSSHRFRRSRSPMHYMYRPRSRSPRICHRFISRYRSRSRS 539
            +   PR     P         S+    R R P  +     ++ P    + + +   + R 
Sbjct: 1511 QKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDRE 1570

Query: 540  RSPYRIRN--PFRGSPKCFRSVSPERMSRRSVRSSDRKKALEDVVQRSGHGTEFNKQKHL 597
            +     RN     G+   +    PE    +   +    K+      +  H +  +     
Sbjct: 1571 KHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTR 1630

Query: 598  EAADKGHSPAQKPKTSSGTKPSVKPTSATKSDSNLGGHSIRCKSKNLEDDTLSECKQVSD 657
            E  +    P    ++ S +  SVK     +S  N+        SK+L+D  + + K+  D
Sbjct: 1631 ETDEAAFEPDYN-ESDSESNVSVK---EEESSGNI--------SKDLKDKIVEKAKESLD 1678

Query: 658  KAVSLQRKLRKEQS 671
             A  +Q  + + QS
Sbjct: 1679 TAAVVQVGISRNQS 1692


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 61/202 (30%), Positives = 86/202 (42%), Gaps = 26/202 (12%)

Query: 470 PSRRNEGNRKENETPRRRSHSPSPRRSRRSSSSHRFRRSRSPMHYMYRPRSRSPRICHRF 529
           P+RR   +R      R RS +P+ RRSR  S   R  RSRSP     R RSR+P      
Sbjct: 599 PTRRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTP------ 652

Query: 530 ISRYRSRSRSRSP-----YRIRNPFRGSPKCFRSVSPERMSRRSVRSSDRKKALEDVVQR 584
               R RSRSR+P      R R P R S +  RS +P R  R   R+  R ++    + R
Sbjct: 653 --ARRGRSRSRTPARRGRSRSRTPARRSGRS-RSRTPARRGRSRSRTPRRGRSRSRSLVR 709

Query: 585 SGHGTEFNKQKHLEAADKGHSPAQKPKTSSGTKPSVKPTSATKSDSNLGGHSIRCKSKNL 644
            G       Q+      +G S       SS  + +   TS  +S SN      + +  + 
Sbjct: 710 RGRSHSRTPQR------RGRS------GSSSERKNKSRTSQRRSRSNSSPEMKKSRISSR 757

Query: 645 EDDTLSECKQVSDKAVSLQRKL 666
              +LS  +  +   +SL+R L
Sbjct: 758 RSRSLSSPRSKAKSRLSLRRSL 779



 Score = 52.0 bits (123), Expect = 6e-06
 Identities = 48/157 (30%), Positives = 71/157 (45%), Gaps = 16/157 (10%)

Query: 478 RKENETPRRRSHSPSPRRSRRSSSSHRFRRSRSPMHYMYRPRSRSPRICHRFISRYRSRS 537
           +K+ +   RRS S SPRR R+ SS  +  RS S      + + RSP    +  S+ + R 
Sbjct: 190 KKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESK---KRKHRSPTPKSKRKSKDKKRK 246

Query: 538 RSRSPYRIRNPFRGSPKCFRSVSPERMSRRSVRSSDRKKALEDVVQRSGHGTEFNKQKHL 597
           RSRS      P   S +  RS S +     S  SSD  ++         H T    +   
Sbjct: 247 RSRS----TTPAPKSRRAHRSTSAD-----SASSSDTSRSRSRSAAAKTHTTALAGRSPS 297

Query: 598 EAADK---GHSPAQKPKTSSGTKPSVKPTSATKSDSN 631
            A+ +   G +P  +P T+S  +PS  P +ATK  S+
Sbjct: 298 PASGRRGEGDAPFSEPGTTSTQRPS-SPETATKQPSS 333



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 58/195 (29%), Positives = 76/195 (38%), Gaps = 29/195 (14%)

Query: 458 RQQYPDWNPEILPSRRNEGNRK--ENETPRRRSHSPSPRRSRRSSSSHRFRRSRSPMHYM 515
           R + P W       RR+   ++   + +P+RR  S SP+R   S S +  RR RS     
Sbjct: 507 RSRSPQW-------RRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARR 559

Query: 516 YRPRSRSPRICHRFISR-------------YRSRSRSRSPYRIRNPFRGSPKCFRSVSPE 562
            R  SRSP    R  SR              R RSRSR+P R R+  R   +  RS S  
Sbjct: 560 GRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRT 619

Query: 563 RMSRRS-------VRSSDRKKALEDVVQRSGHGTEFNKQKHLEAADKGHSPAQKPKTSSG 615
              RRS        RS  R  A      RS       + +    A +G S ++ P   SG
Sbjct: 620 PARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARRSG 679

Query: 616 TKPSVKPTSATKSDS 630
              S  P    +S S
Sbjct: 680 RSRSRTPARRGRSRS 694



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 54/165 (32%), Positives = 77/165 (46%), Gaps = 17/165 (10%)

Query: 478 RKENETPRRRSHSPSPRRS-RRSSSSHRFRRSRSPMHYMYRPRSRSPRICHRFISR-YRS 535
           R  + TP +R HS S     RRS S+ R+ RSRSP     R RSRSP+      SR  + 
Sbjct: 494 RSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQR---RGRSRSPQRPGWSRSRNTQR 550

Query: 536 RSRSRSPYRIRNPFRGSPKC---FRSVSPERMSRRSVRSSDRKKALEDVVQRSGHGTEFN 592
           R RSRS  R R+  R SP      RS +P R  R   R+  R+++      R        
Sbjct: 551 RGRSRSARRGRSHSR-SPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPTR-------R 602

Query: 593 KQKHLEAADKGHSPAQKP-KTSSGTKPSVKPTSATKSDSNLGGHS 636
           + +    A +G S ++ P +  S T+  V+  S ++S +   G S
Sbjct: 603 RSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRS 647



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 46/108 (42%), Positives = 58/108 (53%), Gaps = 17/108 (15%)

Query: 471  SRRNEGNRKENETPRRRSHS---PSP---RRSRRSSSSHRFRRSRSPMHYMYRPRSR-SP 523
            SRR  G  +   T R+RS S   P+P    RSR S ++HR  RSR+P+    R RSR SP
Sbjct: 1835 SRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLISRRRSRSRTSP 1894

Query: 524  RICHRFISRYRSRSRSRSPYRIRNPFRGSP---KCFRSVSPERMSRRS 568
                  +SR RSRSR+ S  R R+  R SP   +  RS +P    RRS
Sbjct: 1895 ------VSRRRSRSRT-SVTRRRSRSRASPVSRRRSRSRTPPVTRRRS 1935



 Score = 48.1 bits (113), Expect = 8e-05
 Identities = 52/137 (37%), Positives = 63/137 (45%), Gaps = 18/137 (13%)

Query: 471  SRRNEGNRKENETPRRRSHSPSP---RRSRRSSSSHRFRRSRSPMHYMYRPRSRS---PR 524
            +RR   +R    T RR     SP   RRSR  +S    RRSRS    + R RSRS   P 
Sbjct: 1966 TRRRSRSRTSPITRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTPPA 2025

Query: 525  ICHRFISRY----RSRSRSRSPYRIRNPFRG-SPKCFRSV-----SPERMSRRSVR--SS 572
            I  R  SR     R RSRSRSP  IR   R  +P+  R       SP  + RRS    SS
Sbjct: 2026 IRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSRTPRTARGKRSLTRSPPAIRRRSASGSSS 2085

Query: 573  DRKKALEDVVQRSGHGT 589
            DR ++      R+  G+
Sbjct: 2086 DRSRSATPPATRNHSGS 2102



 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 46/175 (26%), Positives = 78/175 (44%), Gaps = 23/175 (13%)

Query: 465  NPEIL-PSRRNEGNRKENETPRRRSHSP----------SPRRSRRSSSSHRFRRSRSPMH 513
            +PE+   +R +  +R  + +P  RS +P          SP  + +S SS R R + SP  
Sbjct: 1694 SPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRT 1753

Query: 514  YMYRPRSRSPRICHRFISRYRSRSRSRSPYRIRNPFRGSPKCFRSVSPERMSRRSVRSSD 573
                 R RSP    R + R RSRSR       R   R + +  RS S +  SRR  RS  
Sbjct: 1754 KTTSRRGRSPSPKPRGLQRSRSRSR-------REKTRTTRRRDRSGSSQSTSRRRQRSRS 1806

Query: 574  RKKALEDVVQRSGHGTEFNKQKHLEAADKGHSPAQKPKTSSGTKPSVKPTSATKS 628
            R +    V +R   G+ ++ +      +   + +++ +  S T P+ +  S +++
Sbjct: 1807 RSR----VTRRRRGGSGYHSRSPAR-QESSRTSSRRRRGRSRTPPTSRKRSRSRT 1856



 Score = 45.1 bits (105), Expect = 7e-04
 Identities = 57/220 (25%), Positives = 82/220 (37%), Gaps = 36/220 (16%)

Query: 444  HQNTSTHIESCRQLRQQYPDWNPEILPSRRNEGNRKENETPRRRS---HSPSPRRSRRSS 500
            H ++S H     +++   P     I   + NE    ++ TP+RRS    SP P    R+ 
Sbjct: 835  HSSSSPH----PKVKSGTPPRQGSITSPQANE----QSVTPQRRSCFESSPDPELKSRTP 886

Query: 501  SSH--------RFRRSRSPMHYMYRPRSRSPRICHRFISRYRSRSRSRSPYRIRNPFRGS 552
            S H        R + S  P     R  S  P++      R RS S S SP   R   R +
Sbjct: 887  SRHSCSGSSPPRVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTT 946

Query: 553  PKCFRSVSPERMSRRSVRSSDRKKALEDVVQRSGHGTEFNKQKHLEAADKGHSPAQKPKT 612
            P+  RSVSP          S+ +  L      SG  +   K K      + HS +  P  
Sbjct: 947  PRRSRSVSP---------CSNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHSGSISP-- 995

Query: 613  SSGTKPSVKPTSATKSDSNLGGHSIRCKSKNLEDDTLSEC 652
                 P VK  + T    +L G    C  +  +D  +  C
Sbjct: 996  ----YPKVK--AQTPPGPSLSGSKSPCPQEKSKDSLVQSC 1029



 Score = 44.7 bits (104), Expect = 0.001
 Identities = 49/188 (26%), Positives = 76/188 (40%), Gaps = 22/188 (11%)

Query: 462  PDWNPEILPSRRNEGNRKENET-----PRRRSHSPSPRRSRRSSSSHRFR--------RS 508
            P+  P+   +RR   +  E +T     PRRRS   SP  +R++  S R R        RS
Sbjct: 1659 PEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRS 1718

Query: 509  RSPMHYMYRPRSRSPRICHRFISRYRSRSRSRSPYRIRNPFRGSPKCFRSVSPERMSRRS 568
            R+P  +   P   SP    +  S  R RS S SP       RG     RS SP+    + 
Sbjct: 1719 RTPPRHRRSPSVSSPEPAEKSRSSRRRRSAS-SPRTKTTSRRG-----RSPSPKPRGLQR 1772

Query: 569  VRSSDRKKALEDVVQRSGHGTEFNKQKHLEAADKGHSPAQKPKTSSG---TKPSVKPTSA 625
             RS  R++      +R   G+  +  +  + +       ++ +  SG     P+ + +S 
Sbjct: 1773 SRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSR 1832

Query: 626  TKSDSNLG 633
            T S    G
Sbjct: 1833 TSSRRRRG 1840



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 62/210 (29%), Positives = 84/210 (40%), Gaps = 38/210 (18%)

Query: 469  LPSRRNEGNRKENETPRRRSHSPSP-----RRSRRSSSSHRFRRSRSPMHYMYRPRSRSP 523
            L SRR   +R  +   RRRS S +       RSR S  S R  RSR+P     R RSR+P
Sbjct: 1882 LISRRRSRSRT-SPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTP 1940

Query: 524  RICHRFISR----YRSRSRSRSP--------------YRIRNPFRGSPKCFR----SVSP 561
                R  SR     R RSRSR+P               R R+  R SP   R      SP
Sbjct: 1941 TTRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTRRRSRSRTSP 2000

Query: 562  ERMSRRSVRSS------DRKKALEDVVQRSGHGTEFNKQKHLEA----ADKGHSPAQKPK 611
                R   R+S       R +    + +RS   T    +K   +    A +  S ++ P+
Sbjct: 2001 VTRRRSRSRTSPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSRTPR 2060

Query: 612  TSSGTKPSVKPTSATKSDSNLGGHSIRCKS 641
            T+ G +   +   A +  S  G  S R +S
Sbjct: 2061 TARGKRSLTRSPPAIRRRSASGSSSDRSRS 2090



 Score = 41.6 bits (96), Expect = 0.008
 Identities = 54/196 (27%), Positives = 78/196 (39%), Gaps = 33/196 (16%)

Query: 458 RQQYPDWNPEILPSRRNEGN-----------RKENETPRRRSHSPSPRRSRRSSSSH--- 503
           R + P  +PE LP   +  +           R  + +P     +P+P   R  SSS    
Sbjct: 401 RDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSSPTSK 460

Query: 504 -----RFRRSRSPMHYMYRP--RSRSPRICHRFISRYRSRSRSRSPYRIRNPFRGSPKCF 556
                R +R +S  H   R   RSRSP    R       RSRSR+P +  +    SP+  
Sbjct: 461 NRSHGRAKRDKSHSHTPSRRMGRSRSPATAKR------GRSRSRTPTKRGHSRSRSPQWR 514

Query: 557 RSVSPERMSRRSVRSSDRKKALEDVVQRSGHGTEFNKQK--HLEAADKGHSPAQKPKTSS 614
           RS S +R  R     S +++      QR G     N Q+     +A +G S ++ P T  
Sbjct: 515 RSRSAQRWGR---SRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSRSPAT-R 570

Query: 615 GTKPSVKPTSATKSDS 630
           G   S  P    +S S
Sbjct: 571 GRSRSRTPARRGRSRS 586



 Score = 37.7 bits (86), Expect = 0.11
 Identities = 42/152 (27%), Positives = 60/152 (39%), Gaps = 9/152 (5%)

Query: 471 SRRNEGNRKENETPRRRSHSPSPRRSRRSSSSHRFRRSRSPMHYMYRPRSRSPRICHRFI 530
           S + + +R E+E+ +R+  SP+P+  R+S    R +RSRS        R+          
Sbjct: 212 SSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKR-KRSRSTTPAPKSRRAHRSTSADSAS 270

Query: 531 SRYRSRSRSRSPYRIRNPFRGSPKCFRSVSPERMSRRSVRSSDRKKALEDVVQRSGHGTE 590
           S   SRSRSRS     +    +    RS SP    RR    +   +      QR      
Sbjct: 271 SSDTSRSRSRSAAAKTHT---TALAGRSPSP-ASGRRGEGDAPFSEPGTTSTQRPSSPET 326

Query: 591 FNKQKHLEAADKGHSPAQKPKTSSGTKPSVKP 622
             KQ      DK     +K    S T+PS  P
Sbjct: 327 ATKQPSSPYEDKDKDKKEK----SATRPSPSP 354



 Score = 37.4 bits (85), Expect = 0.15
 Identities = 48/177 (27%), Positives = 63/177 (35%), Gaps = 42/177 (23%)

Query: 466  PEILPSRRNEGNRKENETPRRRS---------HSPSPRRSRRSSSSHRFRRSRSPMHYMY 516
            P  LP R   G+  +   P             H P  R +RR S S    +++S      
Sbjct: 1629 PRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRR 1688

Query: 517  RPRSRSPRICHRFISRYRSRSRSRSP-YRIRNP--FRGSPKCFRSVSPERMSRRSVRSSD 573
            R    SP +  +     RSRS S SP  R R P   R SP    SVS    + +S RSS 
Sbjct: 1689 RSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSP----SVSSPEPAEKS-RSSR 1743

Query: 574  RKKALEDVVQRSGHGTEFNKQKHLEAADKGHSPAQKPKTSSGTKPSVKPTSATKSDS 630
            R+++                           SP  K  +  G  PS KP    +S S
Sbjct: 1744 RRRS-------------------------ASSPRTKTTSRRGRSPSPKPRGLQRSRS 1775



 Score = 36.2 bits (82), Expect = 0.33
 Identities = 54/216 (25%), Positives = 82/216 (37%), Gaps = 26/216 (12%)

Query: 471 SRRNEGNRKENETPRRRSHSPSPRRSRRSSSSHRFRRSRSPMHYMYRPRSRSPRICHRFI 530
           SR ++   + N +P  +    S RRSR  SS     +SR  +       S  P+   +  
Sbjct: 734 SRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTP 793

Query: 531 SRYRSRS-------RSRSPYRIRNPFRGSPKCFRSVSPERMSRRSVRSSDRKKALEDVVQ 583
            R RSRS       +SR+P R        P   +S +P R S  S  SS   K       
Sbjct: 794 PR-RSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSS--SSPHPKVKSGTPP 850

Query: 584 RSGHGTEFNKQKHLEAADKGHSPAQKPKTSSGTKPSVKPTSATKSDSNLGGHS---IRCK 640
           R G  T        +A ++  +P ++    S   P +K  S T S  +  G S   ++  
Sbjct: 851 RQGSITS------PQANEQSVTPQRRSCFESSPDPELK--SRTPSRHSCSGSSPPRVKSS 902

Query: 641 SKNLEDDTLSECKQVSDKAVSLQRKLRKEQSLHYGS 676
           +   +  + S   Q   KA+     +   Q  H GS
Sbjct: 903 TPPRQSPSRSSSPQPKVKAI-----ISPRQRSHSGS 933



 Score = 36.2 bits (82), Expect = 0.33
 Identities = 49/217 (22%), Positives = 82/217 (37%), Gaps = 14/217 (6%)

Query: 462  PDWNPEILPSRRNEGNRKENETPRRRSHSPSPRRSRRSSSSHR-FRRSRSPMHYMYRPRS 520
            P+ N + L  +R     + +   +  + +P  +RSR  SS     + S SP        S
Sbjct: 1503 PELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQERSESDSS 1562

Query: 521  RSPRICHRFISRYRSRSRSRSPYRIRNPFRGSPKCFRS-VSPE-----RMSRRSVRSSDR 574
               +   R  +  R RSRS S   + +  R SP+  RS  SPE     R + R+   SD 
Sbjct: 1563 PDSKAKTR--TPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDS 1620

Query: 575  KKALEDVVQRSGHGTEFNKQKHLEAADKGHSPAQKPKTSSGTKPSVKPTSATKSDSNLGG 634
                +    R+       ++    ++ KG  P+ +  +S+ + P   P S T    +   
Sbjct: 1621 SPEPKAPAPRA-----LPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSS 1675

Query: 635  HSIRCKSKNLEDDTLSECKQVSDKAVSLQRKLRKEQS 671
               + KS+       S       +   L R+ R   S
Sbjct: 1676 PEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASS 1712



 Score = 34.3 bits (77), Expect = 1.2
 Identities = 43/182 (23%), Positives = 72/182 (39%), Gaps = 21/182 (11%)

Query: 479  KENETPRRRSHSPSPRRSRRSSSSHRFRRSRSPMHYMYRPRSR-SPRICHRFISRYRSRS 537
            K + +P+ RS S S   S+  + +   +RSRS        +SR SPR           RS
Sbjct: 1548 KPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPR-----------RS 1596

Query: 538  RSRSPYRIRNPFRGSPKCF---------RSVSPERMSRRSVRSSDRKKALEDVVQRSGHG 588
            RS S   +++  R +P+           ++ +P  + RRS   S  K         S   
Sbjct: 1597 RSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTE 1656

Query: 589  TEFNKQKHLEAADKGHSPAQKPKTSSGTKPSVKPTSATKSDSNLGGHSIRCKSKNLEDDT 648
            +          A +G   + +PKT S T P  + + ++   +     S R +S +   +T
Sbjct: 1657 SSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPET 1716

Query: 649  LS 650
             S
Sbjct: 1717 RS 1718



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 51/181 (28%), Positives = 74/181 (40%), Gaps = 26/181 (14%)

Query: 470  PSRRNEGNRKENETPRRRSHSPSP---------------RRSRRSSSSHRFRRSRSPMHY 514
            P+       + +    RRS S +P               RR  RS +S   RRSRS    
Sbjct: 1858 PAPWKRSRSRASPATHRRSRSRTPLISRRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASP 1917

Query: 515  MYRPRSRS---PRICHRFISR---YRSRSRSRSPYRIRNPFRG-SPKCFRSVSPERMSRR 567
            + R RSRS   P    R  SR    R RSRSR+P   R   R  +P   R  S  R S  
Sbjct: 1918 VSRRRSRSRTPPVTRRRSRSRTPTTRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPI 1977

Query: 568  SVRSSDRKKALEDVVQRSGHGTEFNKQKHLEAADKGHSPAQKPKTSSGTKPSVKPTSATK 627
            + R S R +      +RS   T    ++   +     SP  + ++ S T P+++  S ++
Sbjct: 1978 TRRRS-RSRTSPVTRRRSRSRTSPVTRRRSRSRT---SPVTRRRSRSRTPPAIRRRSRSR 2033

Query: 628  S 628
            +
Sbjct: 2034 T 2034



 Score = 33.1 bits (74), Expect = 2.8
 Identities = 56/249 (22%), Positives = 96/249 (38%), Gaps = 30/249 (12%)

Query: 1365 KGVGQANKPDETSKTSILAVSDVSSSKPSIKAVIVSSPK---AKATVSKTENQKSFPKSV 1421
            KG  Q + PD  S TS   V    S  PS+++   +SPK   ++++   TE     P   
Sbjct: 1058 KGQSQTS-PDHRSDTSSPEVRQSHSESPSLQSKSQTSPKGGRSRSSSPVTELASRSPIRQ 1116

Query: 1422 PRDQINAEKKLSAKEFGLLKPTSARSGLAESSSKFKPTQSSLTRGGSGRISALQG--KLS 1479
             R + +A   L +     + P  +R    +S S   PT  S +  G  R+   +   K++
Sbjct: 1117 DRGEFSASPMLKSG----MSPEQSR---FQSDSSSYPTVDSNSLLGQSRLETAESKEKMA 1169

Query: 1480 KLDYRDITKQSQETEARPSIMKRDDSNNKTLAEQNT----KNPKSTTGRSSKSKEE-PLF 1534
                 D T      + + S     D    +L  ++T       +S  G S ++KE+    
Sbjct: 1170 LPPQEDATASPPRQKDKFSPFPVQDRPESSLVFKDTLRTPPRERSGAGSSPETKEQNSAL 1229

Query: 1535 PFNLDEFVTVDEVIEEVNPSQAKQNPLKGKRKETLKNVPFSELNLKKKKGKTSTPRGVEG 1594
            P +  +    +E++E V  S+     +       LK +  S           S+P   E 
Sbjct: 1230 PTSSQD----EELMEVVEKSEEPAGQILSHLSSELKEMSTSNFE--------SSPEVEER 1277

Query: 1595 ELSFVTLDE 1603
                +TLD+
Sbjct: 1278 PAVSLTLDQ 1286



 Score = 32.3 bits (72), Expect = 4.7
 Identities = 43/136 (31%), Positives = 53/136 (38%), Gaps = 30/136 (22%)

Query: 466  PEILPSRR--------NEGNRKENETPRRRSHSPSPRRSRRSSSSHRFRRSRSPMHYMYR 517
            PE  P++R        +  +   + +    S S S   S  SSSS     S SP      
Sbjct: 2596 PEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPG 2655

Query: 518  P-----------------RSRSPRICHRFISRYR-SRSRSRSPYRIRNPF-RGSPKCFRS 558
            P                 RSRSPR   + I   R SRS S SP   R P  + SP+  +S
Sbjct: 2656 PQALPKPASPKKPPPGERRSRSPR---KPIDSLRDSRSLSYSPVERRRPSPQPSPRDQQS 2712

Query: 559  VSPERMSRRSVRSSDR 574
             S ER SRR  R   R
Sbjct: 2713 SSSERGSRRGQRGDSR 2728


>gi|21040326 SON DNA-binding protein isoform F [Homo sapiens]
          Length = 2426

 Score = 61.2 bits (147), Expect = 9e-09
 Identities = 104/437 (23%), Positives = 183/437 (41%), Gaps = 69/437 (15%)

Query: 468  ILPSRRNEGNRKENETPRRRSHSPSPRRSRRSSSSHRFRRSRSPMHYMYRPRSRSPRICH 527
            I PSRR+    + + TP RRS +PS RRSR  S     RRSR+P       RSR+P    
Sbjct: 1951 ISPSRRSRTPSRRSRTPSRRSRTPS-RRSRTPS-----RRSRTPSR-----RSRTPSRRR 1999

Query: 528  RFISRYRSRSRSRSPYRIRNPFRGSPKCFRSVSPERMSRRSVRSSDRKKALEDVVQRSGH 587
            R  S  R RS S SP R+R   R      R  S   + R+  RSS+R ++ + +      
Sbjct: 2000 RSRSVVRRRSFSISPVRLR---RSRTPLRRRFSRSPIRRKRSRSSERGRSPKRL------ 2050

Query: 588  GTEFNKQKHLEAADKGHSPAQKPKTS----SGTKPSVKPTSATKSDSNLGGHSIRCKSKN 643
             T+ +K + LE A K ++ A   K         KP+  PT   K     GG +I      
Sbjct: 2051 -TDLDKAQLLEIA-KANAAAMCAKAGVPLPPNLKPAPPPTIEEKVAKKSGGATI------ 2102

Query: 644  LEDDTLSECKQVSDKAVSLQRKLRKEQSLHYGSVLLITELPEDGCTEEDVRKLFQP---F 700
              ++   +CKQ++          +++  +      +  E  E+        KL +P   F
Sbjct: 2103 --EELTEKCKQIAQS--------KEDDDVIVNKPHVSDEEEEEPPFYHHPFKLSEPKPIF 2152

Query: 701  GKVNDVLIVPYRKEAYLEMEFKEAITAIMKYIETTPLTIKGKSVKICVPGKKKAQNKEVK 760
              +N     P   ++ + +  +  +++  ++ +    ++ G+ V +   G++   +  V 
Sbjct: 2153 FNLNIAAAKPTPPKSQVTLTKEFPVSSGSQHRKKEADSVYGEWVPVEKNGEENKDDDNVF 2212

Query: 761  KKTLESKKVSAST------LKRDADASKAVEIVTSTSAAKTGQAKASVAKVN----KSTG 810
               L S+ V  ST      L +   +  A ++   +   +  +   + A++N    + TG
Sbjct: 2213 SSNLPSEPVDISTAMSERALAQKRLSENAFDLEAMSMLNRAQERIDAWAQLNSIPGQFTG 2272

Query: 811  KSASSVKSVVTVAVKGNKASIKTAK-------SGGKKSLEAKK------TGNVKNKDSNK 857
             +   V +   +A  G +A IK  +       +GG  ++  +K       G  KNK+ NK
Sbjct: 2273 STGVQVLTQEQLANTGAQAWIKKDQFLRAAPVTGGMGAVLMRKMGWREGEGLGKNKEGNK 2332

Query: 858  -PVTIPENSEIKTSIEV 873
             P+ +   ++ K  + V
Sbjct: 2333 EPILVDFKTDRKGLVAV 2349



 Score = 54.7 bits (130), Expect = 9e-07
 Identities = 117/569 (20%), Positives = 222/569 (39%), Gaps = 71/569 (12%)

Query: 108  PHISASVAVKQSSVTQVTEQSPKVQSRYTKESASSILASFGLSNEDLEELSRYPDEQLTP 167
            P +  +V+V Q S+  V+E S  VQ      S  ++  S        E+    P E +  
Sbjct: 1418 PVLEPAVSVLQPSMI-VSEPSVSVQESTVTVSEPAVTVS--------EQTQVIPTE-VAI 1467

Query: 168  ENMPLILRDIRMRKMGRRLPNLPSQSRN-KETLGSEAVSSNVIDYGHASKYGYTEDPLEV 226
            E+ P+IL    M     +  NL S  +N    +G + ++       H+ +  + E+ L+ 
Sbjct: 1468 ESTPMILESSIMSSHVMKGINLSSGDQNLAPEIGMQEIAL------HSGEEPHAEEHLKG 1521

Query: 227  RIYDPEIPTDEVENEFQSQQNISASVPNPNVICNS-MFPVEDVFRQMDFPGESSNNRSFF 285
              Y+ E     +  +     ++ A     N +C +   PV ++  +   P   +  R+  
Sbjct: 1522 DFYESE---HGINIDLNINNHLIAKEMEHNTVCAAGTSPVGEIGEEKILPTSETKQRTVL 1578

Query: 286  SVESGTKMSGLH---ISGGQSVLEP-IKSVNQSINQTVSQTMS---QSLIPPSMNQQPFS 338
                G   +       S G   LEP     ++ I  T + T+S   +  +  S+  Q   
Sbjct: 1579 DTYPGVSEADAGETLSSTGPFALEPDATGTSKGIEFTTASTLSLVNKYDVDLSLTTQDTE 1638

Query: 339  SELISSVSQQ--ERIPHEPVINSSNVHVG--SRGSKKNYQSQADIPIRSPFGIVKASWLP 394
             +++ S S         E  + + ++H+   S  +  +  ++  +P++     + A   P
Sbjct: 1639 HDMVISTSPSGGSEADIEGPLPAKDIHLDLPSNNNLVSKDTEEPLPVKESDQTLAALLSP 1698

Query: 395  KFSHADAQKMKRLPTPSMMNDYYAAS--------------PRIFPHLCSL-CNVECSHLK 439
            K S    +++   P  ++ +  ++A+              P+    L SL   +E   L 
Sbjct: 1699 KESSGGEKEVPPPPKETLPDSGFSANIEDINEADLVRPLLPKDMERLTSLRAGIEGPLLA 1758

Query: 440  DWIQHQNTSTH----------IESCRQLRQQYPDW---NPEILPSRRNEGNRKENETPRR 486
              +    ++             ES  + +  Y  +         S++N+ NR + E  ++
Sbjct: 1759 SDVGRDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNK-NRDKGEKEKK 1817

Query: 487  RSHSPSPRRSRRSSSSHRFRRSRSPMHYMYRPRSRSPRICHRFISRYRSRS-RSRSPYRI 545
            R  S   R  R  SS H+ R+  S      R RS   +  HR  +R RSRS R R   R 
Sbjct: 1818 RDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSK-SHRSQTRSRSRSRRRRRSSRS 1876

Query: 546  RNPFRGSPKCFRSVSPERMSRR-SVRSSDRKKALEDVVQRSGHGTEFNKQKHLEAADKGH 604
            R+  RG     RSVS E+  R    RS  R++  +    R    T   + +      + H
Sbjct: 1877 RSKSRGR----RSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSH 1932

Query: 605  SPAQKPKTSSGTKP---SVKPTSATKSDS 630
            +P+++ ++ S  +    S+ P+  +++ S
Sbjct: 1933 TPSRRRRSRSVGRRRSFSISPSRRSRTPS 1961


>gi|116812577 LUC7-like 2 [Homo sapiens]
          Length = 392

 Score = 61.2 bits (147), Expect = 9e-09
 Identities = 49/113 (43%), Positives = 59/113 (52%), Gaps = 6/113 (5%)

Query: 472 RRNEGNRKENETPRR-RSHSPSPRRSRRSSSSHRFRRSRS-PMHYMYRPRSRSPRICHRF 529
           RR E  R+E E  RR RSHS +P+RSR  S  HR  RSRS       R RS+S    HR 
Sbjct: 246 RREEREREEREKLRRSRSHSKNPKRSR--SREHRRHRSRSMSRERKRRTRSKSREKRHRH 303

Query: 530 ISRYRSRSRSRSPYRIRNPF--RGSPKCFRSVSPERMSRRSVRSSDRKKALED 580
            SR  SRSRSRS  R R+    R   +  R  S ER   + + S DR ++  D
Sbjct: 304 RSRSSSRSRSRSHQRSRHSSRDRSRERSKRRSSKERFRDQDLASCDRDRSSRD 356



 Score = 34.7 bits (78), Expect = 0.95
 Identities = 31/105 (29%), Positives = 43/105 (40%), Gaps = 19/105 (18%)

Query: 485 RRRSHSPSPRRSRRSSSSHRFRRSRSPMHYMYRPRSRSPRICHRFISRYRSRSRSRSPYR 544
           +R       R  R      + RRSRS         S++P+         RSRSR    +R
Sbjct: 238 KRNQERLKRREEREREEREKLRRSRS--------HSKNPK---------RSRSREHRRHR 280

Query: 545 IRNPFRGSPKCFRSVSPERMSRRSVRSSDRKKALEDVVQRSGHGT 589
            R+  R   +  RS S E+  R   RSS R ++     QRS H +
Sbjct: 281 SRSMSRERKRRTRSKSREKRHRHRSRSSSRSRSRSH--QRSRHSS 323


>gi|21040314 SON DNA-binding protein isoform B [Homo sapiens]
          Length = 2303

 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 67/203 (33%), Positives = 92/203 (45%), Gaps = 34/203 (16%)

Query: 468  ILPSRRNEGNRKENETPRRRSHSPSPRRSRRSSSSHRFRRSRSPMHYMYRPRSRSPRICH 527
            I PSRR+    + + TP RRS +PS RRSR  S     RRSR+P       RSR+P    
Sbjct: 1951 ISPSRRSRTPSRRSRTPSRRSRTPS-RRSRTPS-----RRSRTPSR-----RSRTPSRRR 1999

Query: 528  RFISRYRSRSRSRSPYRIRNPFRGSPKCFRSVSPERMSRRSVRSSDRKKALEDVVQRSGH 587
            R  S  R RS S SP R+R   R      R  S   + R+  RSS+R ++ + +      
Sbjct: 2000 RSRSVVRRRSFSISPVRLR---RSRTPLRRRFSRSPIRRKRSRSSERGRSPKRL------ 2050

Query: 588  GTEFNKQKHLEAADKGHSPAQKPKTS----SGTKPSVKPTSATKSDSNLGGHSI-----R 638
             T+ +K + LE A K ++ A   K         KP+  PT   K     GG +I     +
Sbjct: 2051 -TDLDKAQLLEIA-KANAAAMCAKAGVPLPPNLKPAPPPTIEEKVAKKSGGATIEELTEK 2108

Query: 639  CK---SKNLEDDTLSECKQVSDK 658
            CK       +DD +     VSD+
Sbjct: 2109 CKQIAQSKEDDDVIVNKPHVSDE 2131



 Score = 54.7 bits (130), Expect = 9e-07
 Identities = 117/569 (20%), Positives = 222/569 (39%), Gaps = 71/569 (12%)

Query: 108  PHISASVAVKQSSVTQVTEQSPKVQSRYTKESASSILASFGLSNEDLEELSRYPDEQLTP 167
            P +  +V+V Q S+  V+E S  VQ      S  ++  S        E+    P E +  
Sbjct: 1418 PVLEPAVSVLQPSMI-VSEPSVSVQESTVTVSEPAVTVS--------EQTQVIPTE-VAI 1467

Query: 168  ENMPLILRDIRMRKMGRRLPNLPSQSRN-KETLGSEAVSSNVIDYGHASKYGYTEDPLEV 226
            E+ P+IL    M     +  NL S  +N    +G + ++       H+ +  + E+ L+ 
Sbjct: 1468 ESTPMILESSIMSSHVMKGINLSSGDQNLAPEIGMQEIAL------HSGEEPHAEEHLKG 1521

Query: 227  RIYDPEIPTDEVENEFQSQQNISASVPNPNVICNS-MFPVEDVFRQMDFPGESSNNRSFF 285
              Y+ E     +  +     ++ A     N +C +   PV ++  +   P   +  R+  
Sbjct: 1522 DFYESE---HGINIDLNINNHLIAKEMEHNTVCAAGTSPVGEIGEEKILPTSETKQRTVL 1578

Query: 286  SVESGTKMSGLH---ISGGQSVLEP-IKSVNQSINQTVSQTMS---QSLIPPSMNQQPFS 338
                G   +       S G   LEP     ++ I  T + T+S   +  +  S+  Q   
Sbjct: 1579 DTYPGVSEADAGETLSSTGPFALEPDATGTSKGIEFTTASTLSLVNKYDVDLSLTTQDTE 1638

Query: 339  SELISSVSQQ--ERIPHEPVINSSNVHVG--SRGSKKNYQSQADIPIRSPFGIVKASWLP 394
             +++ S S         E  + + ++H+   S  +  +  ++  +P++     + A   P
Sbjct: 1639 HDMVISTSPSGGSEADIEGPLPAKDIHLDLPSNNNLVSKDTEEPLPVKESDQTLAALLSP 1698

Query: 395  KFSHADAQKMKRLPTPSMMNDYYAAS--------------PRIFPHLCSL-CNVECSHLK 439
            K S    +++   P  ++ +  ++A+              P+    L SL   +E   L 
Sbjct: 1699 KESSGGEKEVPPPPKETLPDSGFSANIEDINEADLVRPLLPKDMERLTSLRAGIEGPLLA 1758

Query: 440  DWIQHQNTSTH----------IESCRQLRQQYPDW---NPEILPSRRNEGNRKENETPRR 486
              +    ++             ES  + +  Y  +         S++N+ NR + E  ++
Sbjct: 1759 SDVGRDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNK-NRDKGEKEKK 1817

Query: 487  RSHSPSPRRSRRSSSSHRFRRSRSPMHYMYRPRSRSPRICHRFISRYRSRS-RSRSPYRI 545
            R  S   R  R  SS H+ R+  S      R RS   +  HR  +R RSRS R R   R 
Sbjct: 1818 RDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSK-SHRSQTRSRSRSRRRRRSSRS 1876

Query: 546  RNPFRGSPKCFRSVSPERMSRR-SVRSSDRKKALEDVVQRSGHGTEFNKQKHLEAADKGH 604
            R+  RG     RSVS E+  R    RS  R++  +    R    T   + +      + H
Sbjct: 1877 RSKSRGR----RSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSH 1932

Query: 605  SPAQKPKTSSGTKP---SVKPTSATKSDS 630
            +P+++ ++ S  +    S+ P+  +++ S
Sbjct: 1933 TPSRRRRSRSVGRRRSFSISPSRRSRTPS 1961


>gi|197276594 RNA binding motif protein 20 [Homo sapiens]
          Length = 1227

 Score = 58.5 bits (140), Expect = 6e-08
 Identities = 31/87 (35%), Positives = 50/87 (57%), Gaps = 2/87 (2%)

Query: 675 GSVLLITELPEDGCTEEDVRKLFQPFGKVNDVLIVPYRKEAYLEMEFKEAITAIMKYIET 734
           G V+ I  LPE  CTE DV  L  PFGKV + +++    +A+LEM + EA  A+++Y + 
Sbjct: 517 GRVVHICNLPEGSCTENDVINLGLPFGKVTNYILMKSTNQAFLEMAYTEAAQAMVQYYQE 576

Query: 735 TPLTIKGKSVKICVPGKKKAQNKEVKK 761
               I G+  K+ +   K+ +  ++KK
Sbjct: 577 KSAVINGE--KLLIRMSKRYKELQLKK 601



 Score = 56.2 bits (134), Expect = 3e-07
 Identities = 117/573 (20%), Positives = 223/573 (38%), Gaps = 101/573 (17%)

Query: 1413 NQKSFPKSVPRDQINAEKKLSAKEFGLLKPTSARSGLAESSSKFKPTQSSLTRGGSGRIS 1472
            ++K  P+ + + +++ E+    +      P S    L  S S +K  +    R       
Sbjct: 710  DRKHHPRQLDKAELD-ERPEGGRPHREKYPRSGSPNLPHSVSSYKSREDGYYR------- 761

Query: 1473 ALQGKLSKLDYRDITKQSQETEARPSIMKRDDSNNKTLAEQNTKNPKSTTGRSSKSKEEP 1532
                K  K  +    KQ Q+   R    ++D++    L E    +P  +       KE+ 
Sbjct: 762  ----KEPKAKWDKYLKQQQDAPGRSR--RKDEAR---LRESRHPHPDDS------GKEDG 806

Query: 1533 LFPFNLDEFVTVDEVIEEVNPSQAKQNPLKGKRKETLKN-----------VPFSELNLKK 1581
            L P          +V      ++AKQN  K K K T ++           +  +E   ++
Sbjct: 807  LGP----------KVTRAPEGAKAKQNE-KNKTKRTDRDQEGADDRKENTMAENEAGKEE 855

Query: 1582 KKGKTSTPRGVEGELSFVTLDEIGEEEDAAAHLAQALVTVDEVIDEE--ELNMEEMVKNS 1639
            ++G   +P+ V  +       E  + E+      Q   +  E   E     NMEE+V   
Sbjct: 856  QEGMEESPQSVGRQEKEA---EFSDPENTRTKKEQDWESESEAEGESWYPTNMEELV--- 909

Query: 1640 NSLFTLDELIDQDDCISHSEPKDVTVLSVAEEQDLLKQERLVTVDEIGEVEELPLNESAD 1699
                T+DE+ +++D I   +  ++  +   +++D +  E  + V        L L+ + D
Sbjct: 910  ----TVDEVGEEEDFIVEPDIPELEEIVPIDQKDKICPETCLCV-----TTTLDLDLAQD 960

Query: 1700 ITFATLNTKGNEGDTVRDSIGFISSQVPED-PSTLVTVDEIQD-DSSDLHLVTLDEVTEE 1757
                 +   GN           IS + P + PS   +     D +   L+L    +  E 
Sbjct: 961  FPKEGVKAVGN-------GAAEISLKSPRELPSASTSCPSDMDVEMPGLNLDAERKPAES 1013

Query: 1758 DED-SLADFNNLKEELNFVTVDEVGEEEDGDNDLKVELAQSKNDHPTDKKGNRKKRAVDT 1816
            +   SL D +  ++E   V        E  D      + Q  +  P +++  +    VD 
Sbjct: 1014 ETGLSLEDSDCYEKEAKGV--------ESSDVHPAPTVQQMSSPKPAEERARQPSPFVDD 1065

Query: 1817 KKTKLESLSQVGPVNENVMEEDLKTMIERHLTAKTPTKRVRIGKTLPSEKAVVTEPAKGE 1876
             KT+     + G    + +EE     IE  L  +              ++ +  E ++  
Sbjct: 1066 CKTR--GTPEDGACEGSPLEEKASPPIETDLQNQA------------CQEVLTPENSRYV 1111

Query: 1877 EAFQMSEVDEESGLKDSEPERKRKKTEDSSSGKSVASD--VPEELDFLVPKAGFFCPICS 1934
            E   +     E     +E E K+  +  S   + V S+  +P  ++F+VP+ GF+C +C 
Sbjct: 1112 EMKSLEVRSPEY----TEVELKQPLSLPSWEPEDVFSELSIPLGVEFVVPRTGFYCKLCG 1167

Query: 1935 LFYSGEK-AMTNHCKSTRHKQNTEKFMAKQRKE 1966
            LFY+ E+ A  +HC+S  H +N +K++++  +E
Sbjct: 1168 LFYTSEETAKMSHCRSAVHYRNLQKYLSQLAEE 1200



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 24/76 (31%), Positives = 42/76 (55%), Gaps = 2/76 (2%)

Query: 1009 RFVHLDNLPEDGL--QCVLCVGLQFGKVDHHVFISNRNKAILQLDSPESAQSMYSFLKQN 1066
            R VH+ NLPE       V+ +GL FGKV +++ + + N+A L++   E+AQ+M  + ++ 
Sbjct: 518  RVVHICNLPEGSCTENDVINLGLPFGKVTNYILMKSTNQAFLEMAYTEAAQAMVQYYQEK 577

Query: 1067 PQNIGDHMLTCSLSPK 1082
               I    L   +S +
Sbjct: 578  SAVINGEKLLIRMSKR 593



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 15/42 (35%), Positives = 24/42 (57%)

Query: 413 MNDYYAASPRIFPHLCSLCNVECSHLKDWIQHQNTSTHIESC 454
           +ND++  +P   PH+CS+C+ +   LKDW  H     H + C
Sbjct: 399 LNDFHGVAPLHLPHICSICDKKVFDLKDWELHVKGKLHAQKC 440



 Score = 40.8 bits (94), Expect = 0.013
 Identities = 21/73 (28%), Positives = 45/73 (61%), Gaps = 1/73 (1%)

Query: 906 VMLVSNLPNKGYSVEEVYDLAKPFGGLKDILILSSHKKAYIEI-NRKAAESMVKFYTCFP 964
           V+ + NLP    +  +V +L  PFG + + +++ S  +A++E+   +AA++MV++Y    
Sbjct: 519 VVHICNLPEGSCTENDVINLGLPFGKVTNYILMKSTNQAFLEMAYTEAAQAMVQYYQEKS 578

Query: 965 VLMDGNQLSISMA 977
            +++G +L I M+
Sbjct: 579 AVINGEKLLIRMS 591



 Score = 39.7 bits (91), Expect = 0.030
 Identities = 48/174 (27%), Positives = 75/174 (43%), Gaps = 15/174 (8%)

Query: 1387 VSSSKPSIKAVIVSSPKAKATVSKTENQKSFPKSVPRDQINAEKKL------SAKEFGL- 1439
            VSS K          PKAK      + Q +  +S  +D+    +        S KE GL 
Sbjct: 749  VSSYKSREDGYYRKEPKAKWDKYLKQQQDAPGRSRRKDEARLRESRHPHPDDSGKEDGLG 808

Query: 1440 LKPTSARSGL-AESSSKFKPTQSSLTRGGSGRISALQGKLSKLDYRDITKQSQE-TEARP 1497
             K T A  G  A+ + K K  ++   + G+        K + +   +  K+ QE  E  P
Sbjct: 809  PKVTRAPEGAKAKQNEKNKTKRTDRDQEGAD-----DRKENTMAENEAGKEEQEGMEESP 863

Query: 1498 SIMKRDDSNNKTLAEQNTKNPKSTTGRS-SKSKEEPLFPFNLDEFVTVDEVIEE 1550
              + R +   +    +NT+  K     S S+++ E  +P N++E VTVDEV EE
Sbjct: 864  QSVGRQEKEAEFSDPENTRTKKEQDWESESEAEGESWYPTNMEELVTVDEVGEE 917



 Score = 32.7 bits (73), Expect = 3.6
 Identities = 39/164 (23%), Positives = 63/164 (38%), Gaps = 7/164 (4%)

Query: 1062 FLKQNPQNIGDHMLTCSLSPKIDLPEVQIEHDPELEKESPGL----KNSPIDESEVQTAT 1117
            F K+  + +G+     SL    +LP        +++ E PGL    +  P  ESE   + 
Sbjct: 961  FPKEGVKAVGNGAAEISLKSPRELPSASTSCPSDMDVEMPGLNLDAERKPA-ESETGLSL 1019

Query: 1118 DSPSVKPNELEEESTPSIQTETLVQQEEPCEEEAEKATCDSDFAVETLELETQGEEVKEE 1177
            +       E +   +  +     VQQ    +   E+A   S F  +     T  +   E 
Sbjct: 1020 EDSDCYEKEAKGVESSDVHPAPTVQQMSSPKPAEERARQPSPFVDDCKTRGTPEDGACEG 1079

Query: 1178 IPLVASASVSIEQFTENAEECALNQQMFNSD-LEKKGAEIINPK 1220
             PL   AS  IE   +N + C       NS  +E K  E+ +P+
Sbjct: 1080 SPLEEKASPPIETDLQN-QACQEVLTPENSRYVEMKSLEVRSPE 1122


>gi|109637759 calpastatin isoform f [Homo sapiens]
          Length = 750

 Score = 57.8 bits (138), Expect = 1e-07
 Identities = 138/672 (20%), Positives = 265/672 (39%), Gaps = 58/672 (8%)

Query: 1292 EKTVDKKNISEKKGNMDEKEEKEFNTKETRMDLQIGTEKAEKNEGRMDAEKVEKMAAMKE 1351
            EKT +  +   +K   DEK+     + ++      GT  A K      A    K ++M  
Sbjct: 29   EKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGA--TSKSSSMN- 85

Query: 1352 KPAENTLFKAYPNKGVGQANKPDETSKTSILAVSDVSSSKPSIKAVIVSSPKAKATVSKT 1411
             P E    K  P K   Q+ KP    K +    S+ + +K ++       P  K+T    
Sbjct: 86   -PTETKAVKTEPEKK-SQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTE--- 140

Query: 1412 ENQKSFPKSVPRDQINAEKKLSAKEFGLLKPTSARSGLAESSSKFKPTQSSLTR--GGSG 1469
                  PK+ P+D I+A  +  A    +      +    +S +   P +S   +  G SG
Sbjct: 141  ------PKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSG 194

Query: 1470 RISALQGKLSKLDYRDITKQSQETEARPSIMKRDDSNNKTLAEQNTKNPKSTTG--RSSK 1527
              +AL   +  L   + T++   T   P +    D  + T  E+  K   +     R   
Sbjct: 195  MDAALDDLIDTLGGPEETEEENTTYTGPEV---SDPMSSTYIEELGKREVTIPPKYRELL 251

Query: 1528 SKEEPLF--PFNLDEFVTVDEVIEEVNPSQAKQNP-LKGKRKETLKNVPFSELNLKKKKG 1584
            +K+E +   P +  + +  D+ I+ ++      +P   GK+ E  ++    +        
Sbjct: 252  AKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVR 311

Query: 1585 KTSTPRGVEGELSFVTL-DEIGEEEDAAAHLAQALVTVD----EVIDEEELNMEEMVKNS 1639
              + P+  + ++   T+ D+  E   A+    QA   +D    + +DE +   E++ K  
Sbjct: 312  SAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCG 371

Query: 1640 NSLFTLDELIDQDDCISHSEPKDVTVLSVAEEQDLLKQERLVTVDEI------GEVEELP 1693
                  DE I  +  +  +  KD   L    E+    +     +DE+       E +E P
Sbjct: 372  ED----DETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKP 427

Query: 1694 L--NESADITFATLNTKGNEGDTVRDSIGFISSQVPEDPSTLVTVDEIQDDSSDLHLVTL 1751
                E  + + A      +E    R S+  I S  PE P+TL     + DD+ +    +L
Sbjct: 428  SKPTEKTEESKAAAPAPVSEA-VCRTSMCSIQSAPPE-PATL--KGTVPDDAVEALADSL 483

Query: 1752 DEVTEEDEDSLADFNNLKEELNFVTVDEVGEEEDG-DNDLKVELAQSKNDHPTDKKGNRK 1810
             +   + ED     + +KE+      +++GE+E+    D ++E  + K+  P   K +++
Sbjct: 484  GKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKE 543

Query: 1811 KRAVDTKKTKLESLSQ--VGPVNENVME-EDLKTMIE-RHLTAKTPTKRVRIG----KTL 1862
            +    ++   L++LS+   GP N + ++ ED K       + ++TP    + G     T 
Sbjct: 544  QLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTS 603

Query: 1863 PSEKAVVTEPAKGEEAF--QMSEVDEESGLKDSEPERKRKKTEDSSSGKSVASDVPEELD 1920
             S+K +     K  ++   +  + DE   ++D   E+ + +  D    +     +P E  
Sbjct: 604  QSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERD--DTIPPEYR 661

Query: 1921 FLVPKAGFFCPI 1932
             L+   G   P+
Sbjct: 662  HLLDDNGQDKPV 673



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 45/144 (31%), Positives = 64/144 (44%), Gaps = 17/144 (11%)

Query: 767 KKVSASTLKRDADASKA----VEIVTSTSAAKTGQAKASVAKVNKSTGKSASS--VKSVV 820
           +K +AS   R A A++     V   TS S +K G+ K S  K   S G S SS       
Sbjct: 6   QKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGT 65

Query: 821 TVAVKGNKASIKTAKSGGKKSLEAK--KTGNVKNKDSNKPVTIPENSEIKTSIEVKATEN 878
             A K + +S  T+KS      E K  KT   K   S KP ++P     K + +  + + 
Sbjct: 66  ASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKPKSLP-----KQASDTGSNDA 120

Query: 879 CAKEAISDAALEATENEPLNKETE 902
             K+A+S +A    E +P  K TE
Sbjct: 121 HNKKAVSRSA----EQQPSEKSTE 140


>gi|4759100 splicing factor, arginine/serine-rich 11 [Homo sapiens]
          Length = 484

 Score = 55.8 bits (133), Expect = 4e-07
 Identities = 61/209 (29%), Positives = 83/209 (39%), Gaps = 27/209 (12%)

Query: 480 ENETPRRRSHSPSPRRSRRSSSSHRFRRSRSPMHYMYRPRSRSPRICHRFISRYRSRSRS 539
           + E  RR S S S  R RR+ SS R RRSRS          RS R  H   S+ RSR RS
Sbjct: 241 KKEEKRRHSRSRSRSRRRRTPSSSRHRRSRS----------RSRRRSH---SKSRSRRRS 287

Query: 540 RSPYRIRNPFRGSPKCFRSVSPERMSRRSVRSSDRKKA---LEDVVQRSGHGTEFNKQKH 596
           +SP R R+  R   +  RS S  R  ++  +   R K         +RS   +   +++ 
Sbjct: 288 KSPRRRRSHSRERGRRSRSTSKTRDKKKEDKEKKRSKTPPKSYSTARRSRSASRERRRRR 347

Query: 597 LEAADKGHSPAQKPKTSSGTKPSVKPTSATKS---------DSNLGGHSIRCKSKNLEDD 647
             +  +     + PK      PS +     K          D      S + KSK+ E D
Sbjct: 348 SRSGTRSPKKPRSPKRKLSRSPSPRRHKKEKKKDKDKERSRDERERSTSKKKKSKDKEKD 407

Query: 648 TLSECKQVSDKAVSLQRKLRKEQSLHYGS 676
              E K  SDK V    +   E+   Y S
Sbjct: 408 --RERKSESDKDVKQVTRDYDEEEQGYDS 434



 Score = 51.2 bits (121), Expect = 1e-05
 Identities = 43/136 (31%), Positives = 61/136 (44%), Gaps = 11/136 (8%)

Query: 470 PSRRNEGNRKENETPRRRSHSPSPRRSRRSSSSHRFRRSRSPMHYMYRPRSRSPRICHRF 529
           P RR   +R+      RRS S S  R ++     + R    P  Y    RSRS     R 
Sbjct: 290 PRRRRSHSRERG----RRSRSTSKTRDKKKEDKEKKRSKTPPKSYSTARRSRS---ASRE 342

Query: 530 ISRYRSRSRSRSPYRIRNPFRGSPKCFRSVSPERMSRRSVRSSDRKKALEDVVQRSGHGT 589
             R RSRS +RSP + R+P R   K  RS SP R  +   +  D++++  D  +RS    
Sbjct: 343 RRRRRSRSGTRSPKKPRSPKR---KLSRSPSPRRHKKEKKKDKDKERS-RDERERSTSKK 398

Query: 590 EFNKQKHLEAADKGHS 605
           + +K K  +   K  S
Sbjct: 399 KKSKDKEKDRERKSES 414


>gi|224548936 hypothetical protein LOC100170229 [Homo sapiens]
          Length = 715

 Score = 54.7 bits (130), Expect = 9e-07
 Identities = 55/185 (29%), Positives = 76/185 (41%), Gaps = 36/185 (19%)

Query: 482 ETPRRRSHSPSP----RRSRRSSSSHRFRRSRSPMHYMYRPRSRSPRICHRFISRYRSRS 537
           E   RRS SPS     R+SR SS     RRSRSP     R +SRSP       ++ R RS
Sbjct: 494 ERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSP-------NKERDRS 546

Query: 538 RSRSPYRIRNPFRGSPKCFRSVSPERMSRRSVRSSDRKKALEDVVQRSGHGTEFNKQKHL 597
           +SRSP   R                R SR   +  DR++       RS       +Q   
Sbjct: 547 QSRSPSEERE--------------HRQSRSPSKERDRRR------WRSPSKERERRQSRS 586

Query: 598 EAADKGHSPAQKPKTSSG-TKPSV----KPTSATKSDSNLGGHSIRCKSKNLEDDTLSEC 652
            + ++ HS ++ P   SG ++P      K  S +++ S  G HS    S    D + S  
Sbjct: 587 SSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTV 646

Query: 653 KQVSD 657
            +  D
Sbjct: 647 PRSPD 651



 Score = 53.1 bits (126), Expect = 3e-06
 Identities = 59/174 (33%), Positives = 78/174 (44%), Gaps = 22/174 (12%)

Query: 471 SRRNEGNRKENE--TPRR-RSHS----PSPRRSR---RSSSSHRFRR-SRSPMHYMYRPR 519
           SR +   + +N+  TPRR RSH+    PS  RS    RSSS  R  R S SP     R +
Sbjct: 332 SRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQ 391

Query: 520 SRSPRICH-----RFISRYRSRSRSRSPYRIRNPFRG-SPK----CFRSVSPERMSRRSV 569
           S SP         R  ++ R RSRSRSPY+ R+  R  SP     C RS SP +   RS 
Sbjct: 392 SGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRS- 450

Query: 570 RSSDRKKALEDVVQRSGHGTEFNKQKHLEAADKGHSPAQKPKTSSGTKPSVKPT 623
           RS    KA +    RS +      +    + ++ HS    P      + S  P+
Sbjct: 451 RSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPS 504



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 51/160 (31%), Positives = 73/160 (45%), Gaps = 19/160 (11%)

Query: 472 RRNEGNRKENETPRRRSHSPSP--RRSRRSSSSHRFRRSRSPMHYMYRPRSRSPRICHRF 529
           RR+    KE +  + RS S     RRSR  S   + R+SRSP     R +SRSP      
Sbjct: 498 RRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSP------ 551

Query: 530 ISRYRSRSRSRSPYRIRNPFRGSPKCFRSVSPERMSRRSVRSSDRKKALEDVVQRSGHGT 589
            S  R   +SRSP + R+  R     +RS S ER  R+S  SS+ +   +    RS +  
Sbjct: 552 -SEEREHRQSRSPSKERDRRR-----WRSPSKERERRQSRSSSEER---DHSRSRSPNKQ 602

Query: 590 EFNKQKHLEAADKGHSPAQKPKTSSGTKPSVKPTSATKSD 629
               +    + +K HS ++ P  S     S   TS+ +SD
Sbjct: 603 SGYSRPRASSKEKAHSRSRTP--SKEGNHSQSRTSSKESD 640



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 51/200 (25%), Positives = 79/200 (39%), Gaps = 26/200 (13%)

Query: 464 WNPEILPSRRNEGNRKENET-PRRRSHSPSPRRSRRSSSSHRFRRSRSPMHYMYRPRSRS 522
           ++P  + SR    N+    + P+  S S SPRRSR  S      R RS  H   R  SR+
Sbjct: 257 YSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRS--HSWKRNHSRA 314

Query: 523 PRICHRFI-------SRYRSRSRSRSPYRIRNPFRG-SPKCFRSVSPERMSRRSVRSSDR 574
                + I       S+ RS S+ +S  + R P RG S    R+ S ER    S RSS +
Sbjct: 315 RSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHS-RSSSK 373

Query: 575 KKALEDVVQRSGHGTEFNKQKHLEAADKGHSPAQKPKTSSGTKPSVKPTSATKSDSNLGG 634
                   +R   G+   ++      + G S +  P        S  P  A     +   
Sbjct: 374 --------ERDHRGSSSPRK------ESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSP 419

Query: 635 HSIRCKSKNLEDDTLSECKQ 654
           +  R +S++   +   +C +
Sbjct: 420 YKARDRSRSRSPNKARDCSR 439



 Score = 38.5 bits (88), Expect = 0.066
 Identities = 44/189 (23%), Positives = 74/189 (39%), Gaps = 15/189 (7%)

Query: 465 NPEILPSRRNEGNRKENETPRRRSHSPSPRRSRRSSSSHRFRRSRSPMHYMYRPRSRSPR 524
           NP    SR+ +   +     R +S+SP+   SR  S +    RSR   H     +SRSPR
Sbjct: 233 NPSPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSH----SQSRSPR 288

Query: 525 ICHRFISRYRSRSRSRSPYRIRNPFRGSPKCFRSVSPERMSRRSVRSSDRKKAL-EDVVQ 583
              R  S+ R+ SR RS    RN  R   +  + +  +       RS  + K+  +    
Sbjct: 289 -RSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTP 347

Query: 584 RSGHGTEFNKQKHLE---------AADKGHSPAQKPKTSSGTKPSVKPTSATKSDSNLGG 634
           R G    +++    E         + ++ H  +  P+  SG   S  P        +   
Sbjct: 348 RRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSP 407

Query: 635 HSIRCKSKN 643
           +  R +S++
Sbjct: 408 NKARDRSRS 416


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 167/831 (20%), Positives = 320/831 (38%), Gaps = 130/831 (15%)

Query: 1095 ELEKESPGLKNSPIDE----SEVQTATDSPSVKPNELEEESTPSIQTETLVQQEEPCEEE 1150
            E+ KE   LK   + +    +E+Q      S   N L ++ T       L    E  E +
Sbjct: 1089 EMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETK------LKAHLEKLEVD 1142

Query: 1151 AEKATCDSDFAVETL-ELETQGEEVKEEIPLVASASVSIEQFTENAEECALNQQMFNSDL 1209
              K+  ++ F  E L EL+   EE K ++  + S    ++   E  +    + +  N  L
Sbjct: 1143 LNKSLKENTFLQEQLVELKMLAEEDKRKVSELTS---KLKTTDEEFQSLKSSHEKSNKSL 1199

Query: 1210 EKKGAEIINPKTALLPSDSVFAEERNLKGILEESPSEAEDFISGITQTMVEAVAEVEKNE 1269
            E K  E       L     +  ++   + +LE   +E  +  S  T  ++  ++  +   
Sbjct: 1200 EDKSLEFKKLSEELAIQLDICCKKT--EALLEAKTNELINISSSKTNAILSRISHCQHRT 1257

Query: 1270 T-VSE-ILPSTCIVTLVPGIPTGDEKTVDKKNISEKKGNMDEKEEKEFNTKETRMDLQ-I 1326
            T V E +L  TC V+ +        +  +  NIS ++    + EEKE   K  + D++ +
Sbjct: 1258 TKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQAT-HQLEEKENQIKSMKADIESL 1316

Query: 1327 GTEKAEKNEGRMDAEKVEKMAAMKEKPAENTLFKAYPNKGVGQANKPDETSKTSILAVSD 1386
             TEK       +  E   +  A  EK +  T  K   ++ +       E  K   + +S 
Sbjct: 1317 VTEKEA-----LQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISS 1371

Query: 1387 VSSSKPSIKAVI---VSSPKAKATVSKTENQKSFPKSVPRDQINAEKKLSAKEFGLLKPT 1443
            +S     +   +   +S  + +A +S    Q    K    DQ+   + LS K   L K  
Sbjct: 1372 LSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQV---QDLSFKVDTLSKEK 1428

Query: 1444 -SARSGLAESSSKF----KPTQSSLTRGGSGRISALQGKLSKLDYRDITKQSQETEARPS 1498
             SA   + + S+KF    K  QS  T+     +  LQ +L        +K++ E + + +
Sbjct: 1429 ISALEQVDDWSNKFSEWKKKAQSRFTQH-QNTVKELQIQLELK-----SKEAYEKDEQIN 1482

Query: 1499 IMKRD-DSNNKT-------LAEQNTKNPKSTTGRSSKSKEEPLFPFNLDEFVTVDEV-IE 1549
            ++K + D  NK        + +  +K  K  +   ++ K +      L++ +T   + IE
Sbjct: 1483 LLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIE 1542

Query: 1550 EVNPSQAKQNPLKG-KRKETLKNVP-FSELNLKKKKGKTSTPRGVEGELSFVTLD----- 1602
             +N      N  K  + KE ++ +  F EL      G+    R  E E   +TL+     
Sbjct: 1543 SLNEVLKNYNQQKDIEHKELVQKLQHFQEL------GEEKDNRVKEAEEKILTLENQVYS 1596

Query: 1603 ---EIGEEEDAAAHLAQALVTVDEVID--EEELNMEEMVKNSNSLFTLDELID--QDDCI 1655
               E+  ++    H+  ++ + +E +   E+ L  E   K +      ++ I   +   +
Sbjct: 1597 MKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLL 1656

Query: 1656 SHSEPKDV--------------TVLSVAEEQDLLKQERLVTVDEIGEVEELPLNESADIT 1701
            S  E K+               T L   E +  + +E+L +V E  + E L +  SA   
Sbjct: 1657 SQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSV-ESSQSETLIVPRSAKNV 1715

Query: 1702 FA-----TLNTKGNEGDTVRDSIGFISSQVPEDPSTLVTVDEIQDDSSDLH--------- 1747
             A       +++G    T  + I  +   + E    L  V + ++++   H         
Sbjct: 1716 AAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQE 1775

Query: 1748 -LVTLDEVTEEDEDSLADFNNLKEELNFVTVDEVGEEEDGDNDLKVELAQSKNDHPTDKK 1806
             L+ L+    +  +  +   +L+EEL           E+ +    + +AQ       +K+
Sbjct: 1776 RLIKLEHAEAKQHEDQSMIGHLQEEL-----------EEKNKKYSLIVAQH-----VEKE 1819

Query: 1807 GNRKKRAVDTKKTKLESLSQVGPVNENVMEEDLKTMIERHLTAKTPTKRVR 1857
            G   K  +  K+             ENV ++  KT+ E+ LT +   ++++
Sbjct: 1820 GG--KNNIQAKQNL-----------ENVFDDVQKTLQEKELTCQILEQKIK 1857



 Score = 52.0 bits (123), Expect = 6e-06
 Identities = 156/837 (18%), Positives = 317/837 (37%), Gaps = 103/837 (12%)

Query: 1108 IDESEVQTATDSPSVKPNELEE--ESTPSIQTETLVQQEEPCEEEAEKATCDSDFAVETL 1165
            +D      + D PS   +E E+   ++ S+  E L+Q+    E             V   
Sbjct: 105  LDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAY 164

Query: 1166 ELETQGEEVKEEIPLVASASVSIEQFTENAEECALNQQM-------FNSDLEKKGAEIIN 1218
            ++  Q E+ K +  L  S   S+ +  E  EE  ++QQ        F++ LE+K   I  
Sbjct: 165  QM-LQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISV 223

Query: 1219 PKTALLPSDSVFAEERNLKGILEESPSEAEDFISGITQTMVEAVAEVEKNETVSEILPST 1278
             +T +            LK  L   P    D +  + Q   +A    ++    S+  P  
Sbjct: 224  LQTQV----------SLLKQRLRNGPMNV-DVLKPLPQLEPQAEVFTKEENPESDGEPVV 272

Query: 1279 CIVTLVPGIPTGDEKTVDKKNISE--KKGNMDEKEEKEFNTKETRMDLQIGTEKAEKNEG 1336
               T V  + T  ++   ++N+ +  K+     KE+    T E     +   E+ ++ E 
Sbjct: 273  EDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEK 332

Query: 1337 RMDAEKVEKMAAMKE-KPAENTLFKAYPNKGVGQANKPDETSKTSILAVSDVSSSKPSIK 1395
              D    EK   + + + A+N + +   +KG+  A    +  +T  +   +++  +  IK
Sbjct: 333  IKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIK 392

Query: 1396 ------------------AVIVSSPKAKATVSKTENQKSFPKSVPRDQINAEKKLSAKEF 1437
                              A      KA +T  KTE  +   K+   +QI   +K S +E 
Sbjct: 393  QMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEE- 451

Query: 1438 GLLKPTSARSGLAESSSKFKPTQSSLTRGGSGRISALQGKLSKLDYRDITKQSQETEARP 1497
                    R  L +  S+ K     + +  S    A   KL KL  +++ ++ QE   + 
Sbjct: 452  --------RISLQQELSRVKQEVVDVMKKSSEEQIA---KLQKLHEKELARKEQELTKKL 500

Query: 1498 SIMKRDDSNNKTLAEQNTKNPKSTTGRSSKSKEEPLFPFNLDEFVTVDEVI--EEVNPSQ 1555
               +R+      +A + +++      +  + +E       L+E     + I  E  N  +
Sbjct: 501  QTREREFQEQMKVALEKSQSEYLKISQEKEQQES----LALEELELQKKAILTESENKLR 556

Query: 1556 AKQNPLKGKRKETLKNVPFSELNLKKKKGKTSTPRGVEGELSFVTLDEIGEEEDAAAHLA 1615
              Q   +  R   L+     E +L++ K ++                ++    +A  +  
Sbjct: 557  DLQQEAETYRTRILELESSLEKSLQENKNQSK---------------DLAVHLEAEKNKH 601

Query: 1616 QALVTVDEVIDEEELNMEEMVKNSNSLFT--LDELIDQDDCISHSEPKDVTVLSVAEEQD 1673
               +TV  ++++ +  +E +    ++L+T  L  L  Q      +E + +      E++ 
Sbjct: 602  NKEITV--MVEKHKTELESLKHQQDALWTEKLQVLKQQ----YQTEMEKLREKCEQEKET 655

Query: 1674 LLKQERLVTVDEIGEVEELPLNESADITFATLNTKGNEGDTV-------RDSIGFISSQV 1726
            LLK + ++    I E+ E  L E  D+    L +  +E   V        + +  +  Q 
Sbjct: 656  LLKDKEIIFQAHIEEMNEKTL-EKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQT 714

Query: 1727 PEDPSTLVTVDEIQDDSSDLHLVTLDEVTEEDEDSLADFNN-LKEELNFVTVDEVGEEED 1785
             +    L   +   D+  + H   +D + +E E S+      LK+++N + +      ++
Sbjct: 715  DKMKQEL---EAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLEL----LLKE 767

Query: 1786 GDNDLKVELAQSKNDHPTDKKGNRKKRAVDTKKTKLESLSQVGPVNENVMEEDLKTMIER 1845
             D  LK   A  +N     K+   + +    K    +S            EE L  + ++
Sbjct: 768  RDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQK 827

Query: 1846 HLTAKTPTKRVRIGKTLPSEKAVVTEPAKGEEA--FQMSEVDEESGLKDSEPERKRK 1900
             L  +  T+R+ + K +   +A   +     +A   Q+ ++ ++   ++SE E+K K
Sbjct: 828  LLDLE--TERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVK 882



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 291/1541 (18%), Positives = 586/1541 (38%), Gaps = 283/1541 (18%)

Query: 638  RCKS---KNLEDDTL--SECKQVSDKAVSLQRKLRKEQSLHYGS-VLLITELPEDGCTEE 691
            RCK     + E  TL  SE + + ++     ++L K + LH      LIT+L        
Sbjct: 297  RCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQL-------R 349

Query: 692  DVRKLFQPFGKVNDVLIVPYRKEAYLEMEFKEAITAIMKYIETTPLTIKGKSVKICVPGK 751
            D + L +   +   ++I   +++ +  +E KE   A ++      +T +G+ ++      
Sbjct: 350  DAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRS-RIKQMTTQGEELREQKEKS 408

Query: 752  KKAQNKEVKKKTLESKKVSASTLKRDADASKAVEIVTSTSAAKTGQAKASVAKVNKSTGK 811
            ++A  +E++K    ++K   +  K  A+  + ++ +  TS  +    +  +++V +    
Sbjct: 409  ERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQE--- 465

Query: 812  SASSVKSVVTVAVKGNKASIKTAKSGGKKSLEAKKTGNVKN--------KDSNKPVTIPE 863
                   VV V  K ++  I   +   +K L  K+    K         ++  K      
Sbjct: 466  -------VVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKS 518

Query: 864  NSE-IKTSIEVKATENCAKEAIS---DAALEATENE--PLNKETEEMCVMLVSNLPNKGY 917
             SE +K S E +  E+ A E +     A L  +EN+   L +E E     ++    +   
Sbjct: 519  QSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEK 578

Query: 918  SVEEVYDLAKPFG---------GLKDILILSSHKKAYIEINRKAAESMVKFYTCFPVLMD 968
            S++E  + +K              K+I ++    K  +E  +   +++  +     VL  
Sbjct: 579  SLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDAL--WTEKLQVLKQ 636

Query: 969  GNQLSISMAPENMN------IKDEEAIFITLVKENDPEANIDTIYDRFVHLDNLPEDGLQ 1022
              Q  +    E         +KD+E IF   ++E + E  ++ +  +   L++L  + L 
Sbjct: 637  QYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMN-EKTLEKLDVKQTELESLSSE-LS 694

Query: 1023 CVLCVGLQFGKVDHHVFISNRNKAILQLDSPESAQSMY------SFLKQNPQNIGDHMLT 1076
             VL    +  + +  V     +K   +L++    Q  +      S +K++  +I      
Sbjct: 695  EVLKARHKLEE-ELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSI--QRTE 751

Query: 1077 CSLSPKIDLPEVQI-EHDPELEKESPGLKNSPID----ESEVQTAT---------DSPSV 1122
             +L  +I+  E+ + E D  L++    ++N   D    E E+Q A+          S + 
Sbjct: 752  KALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATH 811

Query: 1123 KPNELEEESTPSIQ-------TETLVQQEEPCEEEAEKATCDSDFAVETLELETQGEEVK 1175
            +  +  EE    +Q       TE ++  ++  E EA+K    ++     ++++   ++++
Sbjct: 812  EQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLE 871

Query: 1176 EEIPLVASASVSIEQFTENAEECALNQQMFNSDL--------------EKKGAEIINPK- 1220
            ++   +     S+ Q  E+  E    +Q     +              +KK  EI+  K 
Sbjct: 872  KQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKL 931

Query: 1221 TALLPSDSVFAEE-----RNLKGILEESPSEAEDFISGITQTMVEAVAEVEKN--ETVSE 1273
            +A   S  +  EE     +N +  +E+   +A++    + + +++  A+++K    T  E
Sbjct: 932  SAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALE 991

Query: 1274 ILP----------------STCIVTLVPGIPTGDEKTV------------DKKNISEKKG 1305
            +                  S  I   V  + T  ++ +            D  +I EKK 
Sbjct: 992  LSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKL 1051

Query: 1306 NMDEKE----------EKEFNTKETRMDLQI-GTEKAEKN--------EG-RMDAEKVEK 1345
            N   +E          EKE    E +  + + G EK E N        EG + D    E 
Sbjct: 1052 NQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNEL 1111

Query: 1346 MAAMKEKPA-------ENTLFKAYPNKGVGQANKP--------DETSKTSILA------V 1384
               +K+K A       + T  KA+  K     NK         ++  +  +LA      V
Sbjct: 1112 QEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKV 1171

Query: 1385 SDVSSSKPSIKAVIVSSPKAKATVSKTENQKSFPKSVPRDQINAEKKLSAKEFGLLKPTS 1444
            S+++S   +      S   +    +K+   KS       +++  +  +  K+   L    
Sbjct: 1172 SELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAK 1231

Query: 1445 ARSGLAESSSKFKPTQSSLTRGG-------------SGRISALQGKLSKL---------D 1482
                +  SSSK     S ++                +  +S L+ +L +L          
Sbjct: 1232 TNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNIS 1291

Query: 1483 YRDITKQSQETEARPSIMKRDDSNNKTLAEQNTKNPKSTTGRSSKSKEEPLFPFNLDEFV 1542
            ++  T Q +E E +   MK D  +  T  E   K   +    +S+ KE  +         
Sbjct: 1292 FQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASE-KESCITQLK----- 1345

Query: 1543 TVDEVIEEVNPSQAKQNPLKGKRKE--------TLKNVPF-SELNLKKKKGKTSTPRGVE 1593
               E+ E +N     +  LK K+ E        T  NV   + ++L +K+   S+ R   
Sbjct: 1346 --KELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQY 1403

Query: 1594 GELSFVTLDEIGEEEDAAAHLAQALVTVDEVIDEEELNMEEMVKNSNSLFTLDELIDQDD 1653
             E     LD++ +       L++  ++  E +D+      E  K + S FT         
Sbjct: 1404 DEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFT--------- 1454

Query: 1654 CISHSEPKDVTVLSVAEEQDLLKQERLVTVDEIGEVEELPLNESADITFATLNTKGNEGD 1713
                            + Q+ +K+ ++    E+   E    +E  ++    L+ +    D
Sbjct: 1455 ----------------QHQNTVKELQIQL--ELKSKEAYEKDEQINLLKEELDQQNKRFD 1496

Query: 1714 TVRDSIGFISSQVPEDPSTLVT--------VDEIQD--DSSDLHLVTLDEVTEE-DEDSL 1762
             ++  +    S++ +  S L T        + E++D      + + +L+EV +  ++   
Sbjct: 1497 CLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKD 1556

Query: 1763 ADFNNLKEELNFVTVDEVGEEEDGDNDLKVELAQSKNDHPTDKKGNRKKRAVDTKKTKLE 1822
             +   L ++L      E+GEE+D     +V+ A+ K     + +    K  ++TKK +LE
Sbjct: 1557 IEHKELVQKLQH--FQELGEEKDN----RVKEAEEK-ILTLENQVYSMKAELETKKKELE 1609

Query: 1823 SLSQVGPVNENVMEEDLKTM---IERHLTAK-TPTKRVRIGKTLPSEKAVVTEPAKGEEA 1878
             ++    ++    EE+LK +   +E    AK    KR    K    +K ++++  + EE 
Sbjct: 1610 HVN----LSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQ 1665

Query: 1879 FQMSEVDEESGLKDSEPERKRKKTEDSSSGKSVASDVPEELDFLVPKAGFFCPICSLFYS 1938
            ++       S L     ER+R+        KSV S   E L  +VP++       + +  
Sbjct: 1666 YKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETL--IVPRS---AKNVAAYTE 1720

Query: 1939 GEKAMTNHCKSTRHKQN--------TEKFMAKQRKEKEQNE 1971
             E+A +  C    +++         TEK    QR  +E+ E
Sbjct: 1721 QEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEE 1761


>gi|62244004 modulator of estrogen induced transcription isoform b
            [Homo sapiens]
          Length = 1016

 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 96/467 (20%), Positives = 176/467 (37%), Gaps = 79/467 (16%)

Query: 1109 DESEVQTATDSPSVKPNELEEESTPSIQTETLVQQEEPCEEEAEKATCDSDFAVETLELE 1168
            D  E+  +TD+P+ KP + + +             +   +E +  A+ + D  ++  ELE
Sbjct: 64   DNIELTVSTDTPNKKPTKGKGK-------------KHEADELSGDASVEDDAFIKDCELE 110

Query: 1169 TQGEEVKEEIPLVASASVSIEQFTENAEECALNQQMFNSDLEKKGAEIINP------KTA 1222
             Q    ++    +  +    E+F EN EE   ++++ +++  K+  E+I        +  
Sbjct: 111  NQEAHEQDGNDELKDS----EEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKE 166

Query: 1223 LLPSDSVFAEERNLKGIL-----EESPSEAEDFISGITQTMVEAVAEVEKNETVSEILPS 1277
             + S  + A+E      L     EE  +E E  ++    T  E   E+E + TV E    
Sbjct: 167  DIESQEIEAQEGEDDTFLTAQDGEEEENEKEGSLAEADHTAHE---EMEAHTTVKEAEDD 223

Query: 1278 TCIVTLVPG------------IPTGDEKTVDKKNISEKKGNMD------EKEEKEFNTKE 1319
               VT+               + TG    +     S+ K   D      EKE K++    
Sbjct: 224  NISVTIQAEDAITLDFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNA 283

Query: 1320 TRMDLQIGTEKAEKNEGRMDAEKVEKMAAMKEKPAE------NTLFKAYPNKGV-GQANK 1372
               D         K E  +  + VEK A    K AE      +TL K   + G  GQA  
Sbjct: 284  NHKD--------GKKEDCVKGDPVEKEARESSKKAESGDKEKDTLKKGPSSTGASGQAKS 335

Query: 1373 PDETSKTSILAVSDVSSSKPSIKAVIVSSPKAKATVSKTENQKS---------FPKSVPR 1423
              + SK S  +  D   S  S      SS K       + N K+         + K +  
Sbjct: 336  SSKESKDSKTSSKDDKGSTSSTSGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSA 395

Query: 1424 DQINAEKKLSAKEFGLLKPTSARSGLAESSSKFKPTQSSLTRGGSGRISALQGKLSKLDY 1483
              +   +   AK +G++  +S+     E S        +   G    +  ++G  SK + 
Sbjct: 396  KVVTNARSPGAKCYGIVTMSSS----TEVSRCIAHLHRTELHGQLISVEKVKGDPSKKEM 451

Query: 1484 RDITKQSQETEARPSIMKRDDSNNKTLAEQNTKNPKSTTGRSSKSKE 1530
            +   +  +++ +R S  K++ S+  +  + + K  +  +   S+ KE
Sbjct: 452  K--KENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKE 496


>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 [Homo
            sapiens]
          Length = 916

 Score = 52.0 bits (123), Expect = 6e-06
 Identities = 88/393 (22%), Positives = 149/393 (37%), Gaps = 34/393 (8%)

Query: 1091 EHDPELEKESPGLKNSPIDESEVQTATDSPSVKPNELEEESTPSIQTETLVQQEEPCEEE 1150
            E +PE E+E    K SP+  +       +P VK  E E+E     Q E   + E    ++
Sbjct: 496  EEEPEAEEEEVAAKKSPVKAT-------APEVKEEEGEKEEEEG-QEEEEEEDEGAKSDQ 547

Query: 1151 AEKATCDSDFAVETLELETQGEEVKEEIPLVASASVSIEQFTENAEECALNQQMFNSDLE 1210
            AE+   + + + E  E E +  E + E     + +   ++  E +EE A  +++      
Sbjct: 548  AEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELV----- 602

Query: 1211 KKGAEIINPKTALLPSDSVFAEERNLKGILEESPSEAEDFISGITQTMVE---------A 1261
               A++  P+ A  P      EE+  K  + +SP E E   S + ++ VE         +
Sbjct: 603  -ADAKVEKPEKAKSPVPKSPVEEKG-KSPVPKSPVE-EKGKSPVPKSPVEEKGKSPVPKS 659

Query: 1262 VAEVEKNETVSEILPSTCIVTLVPGIPTGDEKTVDKKNISEKKGNMDEKEEKEFNTKETR 1321
              E +    VS+        + VP  P  + K+  K  +   KG   E+EEKE       
Sbjct: 660  PVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKS--KAEVG--KGEQKEEEEKEVKEAPKE 715

Query: 1322 MDLQIGTEKAEKNEGRMDAEKVEKMAAMKEKPAENTLFKAYPNKGVGQANKPDETSKTSI 1381
              ++   EK +    +  AE   K  A+ E        K +  K   +  KP +  K   
Sbjct: 716  EKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKE 775

Query: 1382 LAVSDVSSSKP-SIKAVIVSSPKAKATVSKTENQKSFPKSVPRDQINAEKKLSAKEFGL- 1439
             A  +  S +  S K    S  +  A   + E ++   +         E++      GL 
Sbjct: 776  KAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLD 835

Query: 1440 LKPTSARSGLAESSSKF---KPTQSSLTRGGSG 1469
            L P   + G  +S  K    K  +   + GG G
Sbjct: 836  LSPADEKKGGDKSEEKVVVTKTVEKITSEGGDG 868



 Score = 51.6 bits (122), Expect = 8e-06
 Identities = 100/485 (20%), Positives = 179/485 (36%), Gaps = 73/485 (15%)

Query: 1230 FAEERNLKGILEESPSEAEDFISGITQTMVEAVAEVEKNETVSEILPSTCIVTLVPGIPT 1289
            F EE   +  +E+  SE E+ ++ IT+ +  ++ E EK E   E              P 
Sbjct: 452  FVEEIIEETKVEDEKSEMEEALTAITEELAVSMKE-EKKEAAEEKEEE----------PE 500

Query: 1290 GDEKTVD------KKNISEKKGNMDEKEEKEFNTKETRMDLQIGTEKAE----KNEGRMD 1339
             +E+ V       K    E K    EKEE+E   +E   D    +++AE    + EG  +
Sbjct: 501  AEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSE 560

Query: 1340 AEKVEKMAAMKEKPAENTLFKAYPNKGVGQANKPDETSKTSILAVSDVSSSKP-SIKAVI 1398
             E+ E+     E  AE    +A   K V + ++   T +     V+D    KP   K+ +
Sbjct: 561  KEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEE---LVADAKVEKPEKAKSPV 617

Query: 1399 VSSP---KAKATVSKTENQKSFPKSVPRDQINAEKKLSAKEFGLLKPTSARSGLAESSSK 1455
              SP   K K+ V K+  ++     VP+  +  + K    +  + +   +    +    K
Sbjct: 618  PKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEK 677

Query: 1456 FK-PTQSSLTRGGSGRISALQGKLSKLDYRDITKQSQETEARPSIMKRDDSNNKTLAEQN 1514
             K P   S       +    +G+  + + +++ +  +E +      K  D   K  AE  
Sbjct: 678  AKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESP 737

Query: 1515 ------------TKNPKSTTGRSSKSKEEPLFPFNLDEFVTVDEVIEEVNPSQA------ 1556
                        TK+ K    + +K + +PL      E    +   EE    +       
Sbjct: 738  VKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRK 797

Query: 1557 ----------------KQNPLKGKRKETLKNVPFSELNLKKKKGKTSTPRGVEGELSFVT 1600
                            ++   KG  +E  K V  + L+L     K    +  E  +   T
Sbjct: 798  EDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKT 857

Query: 1601 LDEI-GEEEDAAAHLAQALVTVDEVIDEEELNMEEMVKNSNSLFTLDELIDQDDCISHSE 1659
            +++I  E  D A       VTV + ++E E   EE + ++  +         +   SH+ 
Sbjct: 858  VEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKV---------EKVTSHAI 908

Query: 1660 PKDVT 1664
             K+VT
Sbjct: 909  VKEVT 913



 Score = 32.3 bits (72), Expect = 4.7
 Identities = 57/240 (23%), Positives = 99/240 (41%), Gaps = 28/240 (11%)

Query: 1752 DEVTEEDEDSLADFNNLKEELNFVTVDE-VGEEEDGDNDLKVELAQSKNDHP----TDKK 1806
            +E   E+E+  A  + +K     V  +E   EEE+G  + + E   +K+D      ++K+
Sbjct: 497  EEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKE 556

Query: 1807 GNRKKRAVDTKKTKLESLSQVGPVNENVMEEDLKTMIERHLTAKTPTKRVRIGKTLPSEK 1866
            G+ +K   + ++ + E+ ++     E    ++ K + E+     T  + V   K    EK
Sbjct: 557  GSSEKEEGEQEEGETEAEAE----GEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEK 612

Query: 1867 AVVTEP-----AKGEEAFQMSEVDE--ESGLKDSEPERKRK----KTEDSSSGKSVASDV 1915
            A    P      KG+     S V+E  +S +  S  E K K    K+     GKS  S  
Sbjct: 613  AKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKS 672

Query: 1916 PEELDFLVPKAGFFCPICSLFYSGEKAMTNHCKSTRHKQNTEKFMAKQRKEKEQNEAEER 1975
            P E      KA    P   +  +  KA          K+  EK + +  KE++  + EE+
Sbjct: 673  PVE-----EKAKSPVPKSPVEEAKSKAEVG---KGEQKEEEEKEVKEAPKEEKVEKKEEK 724



 Score = 31.6 bits (70), Expect = 8.1
 Identities = 62/259 (23%), Positives = 93/259 (35%), Gaps = 51/259 (19%)

Query: 1080 SPKIDLPEVQIEHDPELEKESPGLKNSPIDESEVQTATDSPSVKPNELEEESTPSIQTET 1139
            SP  +  +  +   P  EK    +  SP++E++ +        K  E E+E   + + E 
Sbjct: 659  SPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEE-EKEVKEAPKEEK 717

Query: 1140 LVQQEEPCEEEAEKATCDSDFAVETLELETQGEEVKEEIPLVASASVSIEQFTENAEECA 1199
            + ++EE  ++  EK   +S           + E V E + +  S  V +E+  E  EE  
Sbjct: 718  VEKKEEKPKDVPEKKKAES---------PVKEEAVAEVVTITKSVKVHLEK--ETKEEGK 766

Query: 1200 LNQQMFNSDLEKKGAEIINPKTALLPSDSVFAEERNLKGILEESPSEAEDFISGITQTMV 1259
              QQ    + EK G E                      G  EE  S+      G  +  +
Sbjct: 767  PLQQ--EKEKEKAGGE----------------------GGSEEEGSDKG--AKGSRKEDI 800

Query: 1260 EAVAEVEKNETVSEILPSTCIVTLVPGIPTGDEKTV-----DKKNISEKKGNMDEKEEKE 1314
                EVE  E V +        T   G    +EK V     D     EKKG  D+ EEK 
Sbjct: 801  AVNGEVEGKEEVEQ-------ETKEKGSGREEEKGVVTNGLDLSPADEKKGG-DKSEEKV 852

Query: 1315 FNTKETRMDLQIGTEKAEK 1333
              TK        G + A K
Sbjct: 853  VVTKTVEKITSEGGDGATK 871


>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 [Homo
            sapiens]
          Length = 540

 Score = 52.0 bits (123), Expect = 6e-06
 Identities = 88/393 (22%), Positives = 149/393 (37%), Gaps = 34/393 (8%)

Query: 1091 EHDPELEKESPGLKNSPIDESEVQTATDSPSVKPNELEEESTPSIQTETLVQQEEPCEEE 1150
            E +PE E+E    K SP+  +       +P VK  E E+E     Q E   + E    ++
Sbjct: 120  EEEPEAEEEEVAAKKSPVKAT-------APEVKEEEGEKEEEEG-QEEEEEEDEGAKSDQ 171

Query: 1151 AEKATCDSDFAVETLELETQGEEVKEEIPLVASASVSIEQFTENAEECALNQQMFNSDLE 1210
            AE+   + + + E  E E +  E + E     + +   ++  E +EE A  +++      
Sbjct: 172  AEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELV----- 226

Query: 1211 KKGAEIINPKTALLPSDSVFAEERNLKGILEESPSEAEDFISGITQTMVE---------A 1261
               A++  P+ A  P      EE+  K  + +SP E E   S + ++ VE         +
Sbjct: 227  -ADAKVEKPEKAKSPVPKSPVEEKG-KSPVPKSPVE-EKGKSPVPKSPVEEKGKSPVPKS 283

Query: 1262 VAEVEKNETVSEILPSTCIVTLVPGIPTGDEKTVDKKNISEKKGNMDEKEEKEFNTKETR 1321
              E +    VS+        + VP  P  + K+  K  +   KG   E+EEKE       
Sbjct: 284  PVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKS--KAEVG--KGEQKEEEEKEVKEAPKE 339

Query: 1322 MDLQIGTEKAEKNEGRMDAEKVEKMAAMKEKPAENTLFKAYPNKGVGQANKPDETSKTSI 1381
              ++   EK +    +  AE   K  A+ E        K +  K   +  KP +  K   
Sbjct: 340  EKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKE 399

Query: 1382 LAVSDVSSSKP-SIKAVIVSSPKAKATVSKTENQKSFPKSVPRDQINAEKKLSAKEFGL- 1439
             A  +  S +  S K    S  +  A   + E ++   +         E++      GL 
Sbjct: 400  KAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLD 459

Query: 1440 LKPTSARSGLAESSSKF---KPTQSSLTRGGSG 1469
            L P   + G  +S  K    K  +   + GG G
Sbjct: 460  LSPADEKKGGDKSEEKVVVTKTVEKITSEGGDG 492



 Score = 51.6 bits (122), Expect = 8e-06
 Identities = 100/485 (20%), Positives = 179/485 (36%), Gaps = 73/485 (15%)

Query: 1230 FAEERNLKGILEESPSEAEDFISGITQTMVEAVAEVEKNETVSEILPSTCIVTLVPGIPT 1289
            F EE   +  +E+  SE E+ ++ IT+ +  ++ E EK E   E              P 
Sbjct: 76   FVEEIIEETKVEDEKSEMEEALTAITEELAVSMKE-EKKEAAEEKEEE----------PE 124

Query: 1290 GDEKTVD------KKNISEKKGNMDEKEEKEFNTKETRMDLQIGTEKAE----KNEGRMD 1339
             +E+ V       K    E K    EKEE+E   +E   D    +++AE    + EG  +
Sbjct: 125  AEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSE 184

Query: 1340 AEKVEKMAAMKEKPAENTLFKAYPNKGVGQANKPDETSKTSILAVSDVSSSKP-SIKAVI 1398
             E+ E+     E  AE    +A   K V + ++   T +     V+D    KP   K+ +
Sbjct: 185  KEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEE---LVADAKVEKPEKAKSPV 241

Query: 1399 VSSP---KAKATVSKTENQKSFPKSVPRDQINAEKKLSAKEFGLLKPTSARSGLAESSSK 1455
              SP   K K+ V K+  ++     VP+  +  + K    +  + +   +    +    K
Sbjct: 242  PKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEK 301

Query: 1456 FK-PTQSSLTRGGSGRISALQGKLSKLDYRDITKQSQETEARPSIMKRDDSNNKTLAEQN 1514
             K P   S       +    +G+  + + +++ +  +E +      K  D   K  AE  
Sbjct: 302  AKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESP 361

Query: 1515 ------------TKNPKSTTGRSSKSKEEPLFPFNLDEFVTVDEVIEEVNPSQA------ 1556
                        TK+ K    + +K + +PL      E    +   EE    +       
Sbjct: 362  VKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRK 421

Query: 1557 ----------------KQNPLKGKRKETLKNVPFSELNLKKKKGKTSTPRGVEGELSFVT 1600
                            ++   KG  +E  K V  + L+L     K    +  E  +   T
Sbjct: 422  EDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKT 481

Query: 1601 LDEI-GEEEDAAAHLAQALVTVDEVIDEEELNMEEMVKNSNSLFTLDELIDQDDCISHSE 1659
            +++I  E  D A       VTV + ++E E   EE + ++  +         +   SH+ 
Sbjct: 482  VEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKV---------EKVTSHAI 532

Query: 1660 PKDVT 1664
             K+VT
Sbjct: 533  VKEVT 537



 Score = 32.3 bits (72), Expect = 4.7
 Identities = 57/240 (23%), Positives = 99/240 (41%), Gaps = 28/240 (11%)

Query: 1752 DEVTEEDEDSLADFNNLKEELNFVTVDE-VGEEEDGDNDLKVELAQSKNDHP----TDKK 1806
            +E   E+E+  A  + +K     V  +E   EEE+G  + + E   +K+D      ++K+
Sbjct: 121  EEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKE 180

Query: 1807 GNRKKRAVDTKKTKLESLSQVGPVNENVMEEDLKTMIERHLTAKTPTKRVRIGKTLPSEK 1866
            G+ +K   + ++ + E+ ++     E    ++ K + E+     T  + V   K    EK
Sbjct: 181  GSSEKEEGEQEEGETEAEAE----GEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEK 236

Query: 1867 AVVTEP-----AKGEEAFQMSEVDE--ESGLKDSEPERKRK----KTEDSSSGKSVASDV 1915
            A    P      KG+     S V+E  +S +  S  E K K    K+     GKS  S  
Sbjct: 237  AKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKS 296

Query: 1916 PEELDFLVPKAGFFCPICSLFYSGEKAMTNHCKSTRHKQNTEKFMAKQRKEKEQNEAEER 1975
            P E      KA    P   +  +  KA          K+  EK + +  KE++  + EE+
Sbjct: 297  PVE-----EKAKSPVPKSPVEEAKSKAEVG---KGEQKEEEEKEVKEAPKEEKVEKKEEK 348



 Score = 31.6 bits (70), Expect = 8.1
 Identities = 62/259 (23%), Positives = 93/259 (35%), Gaps = 51/259 (19%)

Query: 1080 SPKIDLPEVQIEHDPELEKESPGLKNSPIDESEVQTATDSPSVKPNELEEESTPSIQTET 1139
            SP  +  +  +   P  EK    +  SP++E++ +        K  E E+E   + + E 
Sbjct: 283  SPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEE-EKEVKEAPKEEK 341

Query: 1140 LVQQEEPCEEEAEKATCDSDFAVETLELETQGEEVKEEIPLVASASVSIEQFTENAEECA 1199
            + ++EE  ++  EK   +S           + E V E + +  S  V +E+  E  EE  
Sbjct: 342  VEKKEEKPKDVPEKKKAES---------PVKEEAVAEVVTITKSVKVHLEK--ETKEEGK 390

Query: 1200 LNQQMFNSDLEKKGAEIINPKTALLPSDSVFAEERNLKGILEESPSEAEDFISGITQTMV 1259
              QQ    + EK G E                      G  EE  S+      G  +  +
Sbjct: 391  PLQQ--EKEKEKAGGE----------------------GGSEEEGSDKG--AKGSRKEDI 424

Query: 1260 EAVAEVEKNETVSEILPSTCIVTLVPGIPTGDEKTV-----DKKNISEKKGNMDEKEEKE 1314
                EVE  E V +        T   G    +EK V     D     EKKG  D+ EEK 
Sbjct: 425  AVNGEVEGKEEVEQ-------ETKEKGSGREEEKGVVTNGLDLSPADEKKGG-DKSEEKV 476

Query: 1315 FNTKETRMDLQIGTEKAEK 1333
              TK        G + A K
Sbjct: 477  VVTKTVEKITSEGGDGATK 495


>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
          Length = 793

 Score = 52.0 bits (123), Expect = 6e-06
 Identities = 111/563 (19%), Positives = 203/563 (36%), Gaps = 79/563 (14%)

Query: 1084 DLPEVQIEHDPELEKESPGLKNSPIDESEVQTATDSPSVKPNELEEESTPSIQTETLVQQ 1143
            D  E + E   + E+E    K   I E++V+   +    K  E +EE+         +  
Sbjct: 179  DAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEE---KTTESQEETVVMSLKNGQISS 235

Query: 1144 EEPCEEEAEKATCDSDFAVETLELETQGEEVKEEIPLVAS--ASVSIEQFTENAEECALN 1201
            EEP +EE  +   D     E +E E +     E   L A     +  EQ  + A+E A  
Sbjct: 236  EEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARI 295

Query: 1202 QQMFNSDLEKKGAEIINPKTALLPSDSVFAEERNLKGILEESPSEAEDFISGITQTMVEA 1261
            +    +  +++       +  +   +   AEER  + I EE    AE+      +   E 
Sbjct: 296  EAEEKAAAQERERREAEERERMREEEKRAAEER--QRIKEEEKRAAEE----RQRIKEEE 349

Query: 1262 VAEVEKNETVSEILPSTCIVTLVPGIPTGDEKTVDKKNISEKKGNMDEKEEKEFNTKETR 1321
                E+ + + E                      ++K  +E++     +EE++   +E +
Sbjct: 350  KRAAEERQRIKE----------------------EEKRAAEERQRARAEEEEKAKVEEQK 387

Query: 1322 MDLQIGTEKAEKNEGRMDAEKVEKMAAMK---EKPAENTLFKAYPNKGVGQANKPDETSK 1378
             + Q+  +K    E ++  EKVE+    K   EK A+    +    K      K  E   
Sbjct: 388  RNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLK------KQGEEKG 441

Query: 1379 TSILAVSD-VSSSKPSIKAVIVSSPKAKATVSKTENQKSFPKSVPRDQINAEKKLSAKEF 1437
            T + A  + +   KP+ K   +   K K      E  KSF   + R +   E K    EF
Sbjct: 442  TKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSF---MDRKKGFTEVKSQNGEF 498

Query: 1438 GLLK-----PTSARSGLAESSSKFKPTQSSLTRGGSGRISALQGKLSKLDYRDITKQSQE 1492
               K      T +R G   +S   K  + +       R+  L+ +  + +  +  K  Q+
Sbjct: 499  MTHKLKHTENTFSRPG-GRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQK 557

Query: 1493 TEAR----PSIMKRDDSNNKTLAEQNTKNPKSTTGRSSKSKEEPLFPFNLDEFVTVDEVI 1548
             +        + K+ +   K L E+  +  +    R  + +EE               + 
Sbjct: 558  QQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEK------------RRLK 605

Query: 1549 EEVNPSQAKQNPLKGKRKETLKNVPFSELNLKKKKGKTSTPRG----VEGELSFVTLDEI 1604
            EE+   +A       +  E  + +P   L+  KK  K  TP+G    +E    F+     
Sbjct: 606  EEIERRRA-------EAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQ 658

Query: 1605 GEEEDAAAHLAQALVTVDEVIDE 1627
                  + H A  +  +D  +++
Sbjct: 659  KSSGVKSTHQAAIVSKIDSRLEQ 681



 Score = 38.1 bits (87), Expect = 0.086
 Identities = 83/453 (18%), Positives = 167/453 (36%), Gaps = 38/453 (8%)

Query: 1231 AEERNLKGILEESPSEAEDFISGITQTMVEAVAEVEKNETVSEILPSTCIVTLVPGIPTG 1290
            A ER  +   E    + E+   G     VE  A+   N    E   +T   T V G    
Sbjct: 38   ARERRRRARQERLRQKQEEESLGQVTDQVEVNAQ---NSVPDEEAKTTTTNTQVEGDDEA 94

Query: 1291 D--EKTVDKKNISEKKGNMDEKEEKEFNTKETRMDLQIG-------------TEKAEKNE 1335
               E+   ++   +K+     + +KEF+   T   L +              TEK EK+E
Sbjct: 95   AFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSE 154

Query: 1336 GRMDAEKVEKMAAMKEKPAENTLFKAYPNKGVGQANKPDETSKTSILAVSD-------VS 1388
             R +  ++E+   + +   +N    A  NK   +  + +E  K    ++ +         
Sbjct: 155  SRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEE 214

Query: 1389 SSKPSIKAVIVSSPKAKATVSKTENQKSFPKSVPRDQINAEKKLSAKEFGLLKPTSARSG 1448
             +  S +  +V S K    +S  E ++   +    D+I+  +K+  ++    +   AR  
Sbjct: 215  KTTESQEETVVMSLK-NGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLE 273

Query: 1449 LAESSSKFKPTQSSLTRGGSGRISALQ----GKLSKLDYRDITKQSQETEARPSIMKRDD 1504
             AE   + K  Q         RI A +     +  + +  +  +  +E +      +R  
Sbjct: 274  -AEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIK 332

Query: 1505 SNNKTLAEQNTK---NPKSTTGRSSKSKEEPLFPFNLDEFVTVDEVIEEVNPSQAKQNPL 1561
               K  AE+  +     K       + KEE        +    +E  E+    + K+N  
Sbjct: 333  EEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEE-EKAKVEEQKRNKQ 391

Query: 1562 KGKRKETLKNVPFSELNLKKK-KGK-TSTPRGVEGELSFVTLDEIGEEEDAAAHLAQALV 1619
              ++K  ++        +++K +GK  +  +  E +L    L + GEE+       +  +
Sbjct: 392  LEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKL 451

Query: 1620 TVDE-VIDEEELNMEEMVKNSNSLFTLDELIDQ 1651
              D+    +EE+  E++ K+      +   +D+
Sbjct: 452  QEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDR 484



 Score = 37.4 bits (85), Expect = 0.15
 Identities = 78/401 (19%), Positives = 156/401 (38%), Gaps = 56/401 (13%)

Query: 1513 QNTKNPKSTTGRSSKSKEEPLFPFNLDEFVTVDEVIEEVNPSQAKQNPLKGKRKETLKNV 1572
            QN      TT +  KS E     + ++E  TV +  ++ +   A++N  + K KE     
Sbjct: 138  QNDTAENETTEKEEKS-ESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKE----- 191

Query: 1573 PFSELNLKKKKGKTSTPRGVEGELSFVTLDEIGEEEDAAAHLAQALVTVDEVIDEEELNM 1632
               E   K K+G        E ++  +  ++  E ++    ++   +   ++  EE    
Sbjct: 192  --EEEEEKPKRGSIG-----ENQVEVMVEEKTTESQEETVVMS---LKNGQISSEEPKQE 241

Query: 1633 EEMVKNSNSLFTLDELIDQDDCISHSEPKDVTVLSVAEEQDLLKQERLVTV-DEIGEVEE 1691
            EE  + S+ +   +++ ++D   + +E   +     AEE++ +K E+   + DE   +E 
Sbjct: 242  EEREQGSDEISHHEKMEEEDKERAEAERARLE----AEERERIKAEQDKKIADERARIE- 296

Query: 1692 LPLNESADITFATLNTKGNEGDTVRDSIGFISSQVPEDPSTLVTVDEIQDDSSDLHLVTL 1751
                  A+   A    +  E +  R+ +     +  E+   +   ++   +         
Sbjct: 297  ------AEEKAAAQERERREAEE-RERMREEEKRAAEERQRIKEEEKRAAEERQ------ 343

Query: 1752 DEVTEEDEDSLADFNNLKEELNFVTVDEVGEEEDGDNDLKVELAQSKNDHPTDKKGNRKK 1811
              + EE++ +  +   +KEE      +      + +   KVE      +   +K+   KK
Sbjct: 344  -RIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVE------EQKRNKQLEEKK 396

Query: 1812 RAVDTKKTKLESLSQVGP---VNENVMEED-LKTMIERHLTAKTPTKRVRIGKTLPSEKA 1867
             A+   K K E + Q      VNE   +ED L+T + +    +  TK     + L  +K 
Sbjct: 397  HAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKP 456

Query: 1868 VVTEPAKGEEAFQMSEVDEESGLKDSEPERKRKKTEDSSSG 1908
                       F+  E+ +E   KD EP+ + K   D   G
Sbjct: 457  T----------FKKEEIKDEKIKKDKEPKEEVKSFMDRKKG 487


>gi|104526627 triadin [Homo sapiens]
          Length = 729

 Score = 52.0 bits (123), Expect = 6e-06
 Identities = 87/437 (19%), Positives = 162/437 (37%), Gaps = 52/437 (11%)

Query: 1109 DESEVQTATDSPSVKPNELEEESTPS-------IQTETLVQQEEPCEEEAEKATCDSDFA 1161
            DE   +   D P ++  E+ ++ T         IQT+   +++E  +E+  +       A
Sbjct: 125  DEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKA 184

Query: 1162 VETLELETQGEEVKEEIPLVASASVSIEQFTENAEECALNQQMFNSDLEKKGAEIINPKT 1221
                ++E   ++ K E   +A      +   ++ E+     +    +  K+ A  +  + 
Sbjct: 185  THKEKIE---KKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVK-EV 240

Query: 1222 ALLPSDSVFAEERNLKGILEESPSEAEDFISGITQTMVEAVAEVEKNETVSEILPSTCIV 1281
               PS     E++    + +    +   F   +    V    +  ++  +   LP+    
Sbjct: 241  QKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQAS 300

Query: 1282 TLVPGIPTGDEKTVDKKNISEKKGNMDEKEEKEFNTKETRMDLQIGTEKAEKNEGRMDAE 1341
               P  P  +EK  +KK   +K  +  +K+EKE   K++  +  I  EK E  +     +
Sbjct: 301  RPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQ 360

Query: 1342 KVEKMAAMKEKPAENTLFKAYPNKGVGQANKPDETSKTSILAVSDVSSSKPSIKAVIVSS 1401
               K+AA                     A K DE  +           SK + K   V  
Sbjct: 361  GTVKIAAQ-------------------AAAKKDEKKE----------DSKKTKKPAEVEQ 391

Query: 1402 PKAKATVSK---TENQKSFPK--SVPRD-QINAEKKLSAKEFGLLKPTSARSGLAESSSK 1455
            PK K    K    E  KS  K  SVP D Q+ A+ + + +E G +    A  G  E  + 
Sbjct: 392  PKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTT 451

Query: 1456 FKPTQSSLTRGGSGRISALQGKLSKLDYRDITKQSQETEARPSIMKRDDSNNKTLAEQNT 1515
             K  +  + +  SG+ S++      +  ++    +   E  P   K+D+  +K   E   
Sbjct: 452  -KTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPE-TKKDEKMSKAGKEVKP 509

Query: 1516 KNPKSTTGRSSKSKEEP 1532
            K P+       K +E+P
Sbjct: 510  KPPQ----LQGKKEEKP 522



 Score = 51.2 bits (121), Expect = 1e-05
 Identities = 94/440 (21%), Positives = 159/440 (36%), Gaps = 63/440 (14%)

Query: 548 PFRGSPKCFRSVSPERMSRRSVRSSDRKKALEDVVQRSGHGTEFNKQKHLEAADKGHSPA 607
           P   SP        ++ + + V S  +KK  ED+ ++S   T  + +K          P 
Sbjct: 302 PTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEK--------KEPG 353

Query: 608 QKPKTSSGTKPSVKPTSATKSDSNLGGHSIRCKSKNLEDDTLSECKQVSDKAVSLQRKLR 667
           +  +T  GT       +A K +      S + K     +    + ++  +K V   +  +
Sbjct: 354 KASETKQGTVKIAAQAAAKKDEKK--EDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPK 411

Query: 668 KEQSLHYGSVLLITELPEDGCTEEDVRKLFQPFGKVNDVLIVPYRKE----AYLEMEFKE 723
           KE S           +P D   +    +  +  G V+    VP +KE      +E E ++
Sbjct: 412 KEHS-----------VPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRK 460

Query: 724 AITAIMKYIETTPLTIKGKSVKICVPGKKKAQNKEVKK--------KTLESKKVSASTLK 775
             +     I      IKGK  K  VP   K +  E KK        K ++ K       K
Sbjct: 461 EKSGKTSSILKDKEPIKGKEEK--VPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKK 518

Query: 776 RDADASKAVEIVTSTSAAKTGQAKASVAKVNK--STGKSASSV-KSVVTVAVKGNKASIK 832
            +    +  +      + K    K  + K  K  S GK    V K V  V ++      K
Sbjct: 519 EEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIE------K 572

Query: 833 TAKSGGKKSLEAKKTGNVKNKDSNKPVTIPENSEIKTSIEVKATENCAKEAISDAALEAT 892
           TAK    K  E ++      K ++KP   P+ +   T    K TE   KE+   A ++  
Sbjct: 573 TAKPKPTKKAEHREREPPSIK-TDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHL 631

Query: 893 ENEPLNKETEEMCVMLVSNLPNKGYSVEEVYDLAKPFGGLKDILILSSHKKA---YIEIN 949
             E ++   E +              +  V    KP    KD+  + + KKA     +++
Sbjct: 632 REEKVSTRKESL-------------QLHNVTKAEKPARVSKDVEDVPASKKAKEGTEDVS 678

Query: 950 RKAAESMVKFYTCFPVLMDG 969
               +S + F+ C  V +DG
Sbjct: 679 PTKQKSPISFFQC--VYLDG 696



 Score = 40.8 bits (94), Expect = 0.013
 Identities = 69/351 (19%), Positives = 120/351 (34%), Gaps = 42/351 (11%)

Query: 554 KCFRSVSPERMSRRSVRSSDRKKALEDVVQRSGHGTEFNKQKHLEAADKGHSPAQKPKTS 613
           K  +   PER  +  V   +++K  E V ++        K  H E  +K     +KP+T 
Sbjct: 147 KTEKQEKPERKIQTKVTHKEKEKGKEKVREKE---KPEKKATHKEKIEK----KEKPETK 199

Query: 614 SGTKPSVKPTSATKSDSNLGGHSIRCKSKNLEDDTLSECKQVSDKAVSLQRKLRKEQSLH 673
           +  K   K  +A KS+            K ++     + KQ + K   +Q+   K +   
Sbjct: 200 TLAKEQKKAKTAEKSEEKT--------KKEVKGGKQEKVKQTAAKVKEVQKTPSKPKE-- 249

Query: 674 YGSVLLITELPEDGCTEEDVRKLFQPFGKVNDVLIVPYRKEAYLEMEFKEAITAIMKYIE 733
                           E+  +       + +      Y  + ++  + K   +  +    
Sbjct: 250 ---------------KEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAI---- 290

Query: 734 TTPLTIKGKSVKICVPGKKKAQNKEVKKKTLESKKVSASTLKRDADASKAVEIVTSTSAA 793
             P  +  +      P     + KE +KK  E K  S +  K   D  K  E  T+    
Sbjct: 291 --PPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVE 348

Query: 794 KTGQAKASVAKVNK-STGKSASSVKSVVTVAVKGNKASIKTAKSGGKKSLEAKKTGNVKN 852
           K    KAS  K         A++ K       K  K   +  +  GKK  E K+      
Sbjct: 349 KKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQ-EKKEKHVEPA 407

Query: 853 KDSNKPVTIPENSEIKTSIEVKATENCAKEAISDAALEATENEPLNKETEE 903
           K   K  ++P + ++K   E +A E     +I   A+   + E   K  E+
Sbjct: 408 KSPKKEHSVPSDKQVKAKTE-RAKEEIGAVSIK-KAVPGKKEEKTTKTVEQ 456



 Score = 34.3 bits (77), Expect = 1.2
 Identities = 86/363 (23%), Positives = 141/363 (38%), Gaps = 69/363 (19%)

Query: 1095 ELEKESPGLKNSPIDESEVQTATDSPSVKPNELEEESTPSIQTETLVQQEEPCEEEAEK- 1153
            ++EK+ PG K S   +  V+ A  + + K +E +E+S  + +   + Q +   +E+ EK 
Sbjct: 346  DVEKKEPG-KASETKQGTVKIAAQA-AAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKH 403

Query: 1154 ----ATCDSDFAVET-LELETQGEEVKEEIPLV----ASASVSIEQFTENAEECALNQQM 1204
                 +   + +V +  +++ + E  KEEI  V    A      E+ T+  E+    ++ 
Sbjct: 404  VEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKS 463

Query: 1205 FNSDLEKKGAEIINPKTALLPSD-------------------SVFAEERNLKGILEESPS 1245
              +    K  E I  K   +P+                     V  +   L+G  EE P 
Sbjct: 464  GKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPE 523

Query: 1246 -----EAEDFISGITQTMVEAVAEVEKNETVSEILPSTCIVTLVPGIPTGDEKTVDKKNI 1300
                 EA+  IS   Q   + + + EK  TVS   P   ++  V  +    EKT   K  
Sbjct: 524  PQIKKEAKPAISEKVQIHKQDIVKPEK--TVSHGKPEEKVLKQVKAVTI--EKTAKPK-- 577

Query: 1301 SEKKGNMDEKEEKEFNT-------KETRMDLQIGTEKAE------KNEGRMDAEKVEKMA 1347
              KK    E+E     T       K T    + G +K E      K +  M   + EK++
Sbjct: 578  PTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVS 637

Query: 1348 AMKEKPAENTLFKAYPNKGVGQANKPDETSKTSILAVSDVSSSKPSIKAV-IVSSPKAKA 1406
              KE         +     V +A KP   SK     V DV +SK + +    VS  K K+
Sbjct: 638  TRKE---------SLQLHNVTKAEKPARVSKD----VEDVPASKKAKEGTEDVSPTKQKS 684

Query: 1407 TVS 1409
             +S
Sbjct: 685  PIS 687



 Score = 33.1 bits (74), Expect = 2.8
 Identities = 30/135 (22%), Positives = 55/135 (40%), Gaps = 9/135 (6%)

Query: 1779 EVGEEEDGDNDLKVELAQSKNDHPTDKKGNRKKRAVDTKKTKLESLSQ--VGPVNENVME 1836
            +  E + G   +  + A  K++   D K  +K   V+  K K +   +  V P      E
Sbjct: 354  KASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKE 413

Query: 1837 EDLKTMIERHLTAKTPTKRVRIG-----KTLPSEKAVVTEPAKGEEAFQMSEVDEESGLK 1891
              + +  ++ + AKT   +  IG     K +P +K   T     +E  +       S LK
Sbjct: 414  HSVPS--DKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILK 471

Query: 1892 DSEPERKRKKTEDSS 1906
            D EP + +++   +S
Sbjct: 472  DKEPIKGKEEKVPAS 486


>gi|221219020 NYD-SP11 protein [Homo sapiens]
          Length = 2873

 Score = 51.6 bits (122), Expect = 8e-06
 Identities = 162/818 (19%), Positives = 317/818 (38%), Gaps = 107/818 (13%)

Query: 1126 ELEEESTPSIQTETLVQQEEP---------CEEEAEKATCDSDFAVETLELETQGEEVKE 1176
            +L +E     Q E  + QEE           +++ E A  +  FA +   L  +GE++ +
Sbjct: 1594 KLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQ 1653

Query: 1177 EIPLVASASVSIEQFTENAEECALNQQMFNSDLEKKGAEIINPKTAL------LPS--DS 1228
            E   +A      ++  +  E+ A  ++     L KKG ++   K  L      LP    +
Sbjct: 1654 EAEKLAQKR---KKLAKKWEKVAREEEK----LAKKGGKLAEVKNILAQKVEELPQREQN 1706

Query: 1229 VFAEERNLKGILEESPSEAEDFISGITQTMVEAVAEVEKNETVSEILPSTCIVTLVPGIP 1288
            +  +E+ L   LEE   + E+      +   E    VE+ + ++E               
Sbjct: 1707 LDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAE--------------- 1751

Query: 1289 TGDEKTV--DKKNISEKKGNMDEKEEKEFNTKETRMDLQIGTEKAEKNEGRMDAEKVEKM 1346
              +E+ +   ++ +SE++  + ++EE     KE     +    + E+  GR   + +EK 
Sbjct: 1752 --EEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKK 1809

Query: 1347 AAMKEKPAE--NTLFKAYPNKGVGQANKPDETSKTSILAVSD-VSSSKPSIKAVIVSSPK 1403
              + +K     N++ +   NK +    K     K ++    + ++  K ++         
Sbjct: 1810 MKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTH 1869

Query: 1404 AKATVSKTENQKSFPKSVPRDQINAEKKLSAKEFGLLKPTSARSGLAESSSKFKPTQSSL 1463
            +K  + + +N+      +       E+KL+ ++  ++K    +  LAE+  K    + SL
Sbjct: 1870 SKKQLVQVKNKLGMFNKI---LAQVEEKLTQEKETVIK---KKEKLAETEKKLVQVEDSL 1923

Query: 1464 TRGGSG----------RISALQGKLSKLDYRDITKQSQETEARPSIMKRDDSNNKTLAEQ 1513
             +                + +QGK       DI K   E +A    MKR       L E 
Sbjct: 1924 AKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAK---EEKALNLEMKRLAEEKMRLVEG 1980

Query: 1514 NTKNPKSTTGRSSKSK-----EEPLF--PFNLDEFVTVDE----VIEEVNPSQAKQNPLK 1562
                 K  T  +S+ +     E+ LF    +L+E + + E     +EE   ++ K    +
Sbjct: 1981 KETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTR 2040

Query: 1563 GKR---KETLKNVPFSELNLKKKKGKTSTP---RGVEGELSFVTLDE--IGEEEDAAAHL 1614
            G+R   +   K    S   +KK++  +  P     +   L  +T DE  + +EE     +
Sbjct: 2041 GQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKM 2100

Query: 1615 AQALVTVDEVIDEEELNMEEMVKNSNSLFTLDELIDQDDCISHSE-PKDVTVLSVAEEQD 1673
             +AL      + E  L++E+         +  ++ + D     SE  KD   L+  + + 
Sbjct: 2101 KRAL-----FVKERRLSIEQ---------SKLDIKEWDFSEKRSELTKDEKKLARKQRKL 2146

Query: 1674 LLKQERLVTVDEIGEVEELPLNESADITFATLNTKGNEGDTVRDSIGFISSQVPEDPSTL 1733
              K  R++  +E    EE  L  +   +   L+ +   G    + I F+  +  +     
Sbjct: 2147 ANKMRRMINKEEKMTEEESKL--ARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAK 2204

Query: 1734 VTVDEIQDDSSDLHLVTLDEVTEEDEDSLADFNNLKEELNFVTVDEVGEEEDGDNDLKVE 1793
                  +  SS +  V  +E   E+ +SL D    +E L+    +E  EEE+ + +   E
Sbjct: 2205 RGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEE---E 2261

Query: 1794 LAQSKNDHPTDKKGNRK---KRAVDTKKTKLESLSQVGPVNENVMEEDLKTMIERHLTAK 1850
            + + + +   +++G  K   K   + KK K E   +     E V EE  + M E    + 
Sbjct: 2262 VREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESL 2321

Query: 1851 TPTKRVRIGKTLPSEKAVVTEPAKGEEAFQMSEVDEES 1888
            +  +      +L  E     E  K E+ F++ E   +S
Sbjct: 2322 SDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKS 2359



 Score = 39.3 bits (90), Expect = 0.039
 Identities = 168/923 (18%), Positives = 343/923 (37%), Gaps = 129/923 (13%)

Query: 1084 DLPEVQIEHDPELEKESPGLKNSPIDESE--VQTATDSPSVKPNELEEESTPSIQTETLV 1141
            D  EV +E +   E E    K   + E +  +Q       +       E   + +   L 
Sbjct: 1540 DEEEVTLEEEVSREGEE---KEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLA 1596

Query: 1142 QQEEP-CEEEAEKATCDSDFAVETLELETQGEEVKEEIPLVASASVSIEQFTENAEECAL 1200
            Q+EE   +EE + A  +   A   +++     E+ +     A    ++ Q  E   + A 
Sbjct: 1597 QEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAE 1656

Query: 1201 NQQMFNSDLEKKGAEIINPKTALLPSDSVFAEERNLKGILEESPSEAEDFISGITQTMVE 1260
                    L KK  ++   +  L       AE +N+     E   + E  +    + + +
Sbjct: 1657 KLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQ 1716

Query: 1261 AVAEVEKNETVSEILPSTCIVTLVPGIPTGDEKTVDKKNISEKKGNMDEKEEKEFNTKET 1320
             + E+E +                      +E +  ++ +++++G + E+++K    +E 
Sbjct: 1717 ELEELEWDM---------------------EELSWKEEELNQEEGKLVEEKKKLAEEEEA 1755

Query: 1321 ----RMDLQIGTEKAEKNEGRMDAEKVEKMAAMKEK-PAENTLFKAYPNKGVGQANKPDE 1375
                R  L     K  + E  +  EK EK+A  KEK P E         + + +  K  +
Sbjct: 1756 LAWQREKLSEEETKLAQEEELLIQEK-EKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQ 1814

Query: 1376 TSKTSILAVSDVSSSKPSIKAVIVSSPKAKATVSKTENQKSFPKSVPRDQINAEKKLSAK 1435
              +  I ++ +++ +K     +I+   K  A   K   Q+             ++KL+ +
Sbjct: 1815 KRERWINSMEELTKNK-----MILYQKKNLAQEKKNLAQE-------------KEKLAQR 1856

Query: 1436 EFGLLKPTSARSGLAESSSKFKPTQSSLTRGGSGRISA-LQGKLSKLDYRDITKQSQETE 1494
            +  LL     +  L  S  +    ++ L  G   +I A ++ KL++     I K+ +  E
Sbjct: 1857 KENLLYN---KERLTHSKKQLVQVKNKL--GMFNKILAQVEEKLTQEKETVIKKKEKLAE 1911

Query: 1495 ARPSIMKRDDS---NNKTLAEQNTK---------NPKSTTGRSSKSKEEPLFPFNLDEFV 1542
                +++ +DS     + LA++  K           K   G    +KEE      +    
Sbjct: 1912 TEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLA 1971

Query: 1543 TVDEVIEEVNPSQAKQNPLKGKRKETLKNVPFSELNLKKKKGKTSTPRGVEGELSFVTLD 1602
                  E++   + K+   KG+  ET +    +++  +  + K S               
Sbjct: 1972 E-----EKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSL-------------- 2012

Query: 1603 EIGEEEDAAAHLAQALVTVDEVIDEEELNMEE----MVKNSNSLFTLD-ELIDQDDCISH 1657
                EE    H  + L   +  I + +L         V+    L     +LI + + +S 
Sbjct: 2013 ----EEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSK 2068

Query: 1658 SEPKDVTVLSVAEEQDLLKQERLVTVDEIGEVEELPLNESADITFATLNTKGNEGDTVRD 1717
               K   +L     Q L + ER +T +EI   +   +  +  +    L+ + ++ D    
Sbjct: 2069 EPAKLNKILKAL--QKLTRDERKLTQEEIKMTK---MKRALFVKERRLSIEQSKLDIKEW 2123

Query: 1718 SIGFISSQVPEDPSTLVTVDEIQDDSSDLHLVTLDEVTEEDEDSLADFNNLKEELNFVTV 1777
                  S++ +D   L        +     +   +++TEE+       + L  + + V +
Sbjct: 2124 DFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEE-------SKLARKHSEVIL 2176

Query: 1778 DEVGEEEDGDNDLKVE--LAQSKNDHPTDKKGNRKKRAVDTKKTKLESLSQVGPVNENVM 1835
            D+  EEE G  + +V   L +        K+G++ K    ++  ++ES        E+++
Sbjct: 2177 DD--EEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLL 2234

Query: 1836 EEDLKTMIERHLTAKTPTKRVRIGKTLPSEKAVVTEPAKGEEAFQMSEVDEESGLKDSEP 1895
            +E     +E+  +  +  +  R  +    E+ V  E    EE  +  E  EE  ++  E 
Sbjct: 2235 DE-----LEKQESLSSEEEEEREEEEEREEEEVREE----EEERKEEEEGEEKQVEKEEE 2285

Query: 1896 ERKRKKTEDSSSGKSVASDVPEELDFLVPKAGFFCPICSLFYSGEKAMTNHCKSTRHKQN 1955
            E+K+KK E          +V EE + ++ +        +   S E+     C S   + +
Sbjct: 2286 EKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEE------TESLSDEEEEEESC-SLEEEVD 2338

Query: 1956 TEKFMAKQRKEKEQNEAEERSSR 1978
             EK + K+ K+ +  E   +S R
Sbjct: 2339 REKEILKKEKQFKLQEQRRKSLR 2361



 Score = 34.3 bits (77), Expect = 1.2
 Identities = 59/302 (19%), Positives = 128/302 (42%), Gaps = 51/302 (16%)

Query: 1142 QQEEPCEEEAEKATCDSDFAVETLELETQGEEVKEEIPLVASASVSIEQFTENAEECALN 1201
            ++E+  EEE++ A   S+  ++  + E  G E +E IP +        +  + A+     
Sbjct: 2156 KEEKMTEEESKLARKHSEVILD--DEEEGGIEEEEVIPFLKRRW----RKRKEAKRGDKP 2209

Query: 1202 QQMFNSDLEKKGAEIINPKTALLPSDSVFAEERNLKGILEESPSEAEDFISGITQTMVEA 1261
            ++ F+S +++            + S+  F+EE  ++ +L+E   E ++ +S   +   E 
Sbjct: 2210 KEKFSSQVDE------------VESEEHFSEE--MESLLDEL--EKQESLSSEEEEEREE 2253

Query: 1262 VAEVEKNETVSEILPSTCIVTLVPGIPTGDEKTVDKKNISEKKGNMDEKEEKEFNTKETR 1321
              E E+ E   E                 +E+  +++   EK+   +E+E+K+   ++ +
Sbjct: 2254 EEEREEEEVREE-----------------EEERKEEEEGEEKQVEKEEEEKKKKKKEKKK 2296

Query: 1322 MDLQIGTEKAEKNEGRMDAEKVEKMAAMKEK----------PAENTLFKAYPNKGVGQAN 1371
             ++Q   E  E+ E  M  E+ E ++  +E+            E  + K      + +  
Sbjct: 2297 EEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQR 2356

Query: 1372 KPDETSKTSILAV-SDVSSSK-PSIKAVIVSSPKAKATVSKTENQKSFPKSVPRDQINAE 1429
            +     +  +L++   V   K  +I+  ++ SP  K   +  E ++  P  VP  QI+ E
Sbjct: 2357 RKSLRGRERVLSILRGVPHGKGRAIRLGVLKSPLKKLMSTALEMKEKTPVPVPEKQISWE 2416

Query: 1430 KK 1431
             K
Sbjct: 2417 DK 2418


>gi|33356174 pinin, desmosome associated protein [Homo sapiens]
          Length = 717

 Score = 51.6 bits (122), Expect = 8e-06
 Identities = 88/435 (20%), Positives = 178/435 (40%), Gaps = 44/435 (10%)

Query: 1108 IDESEVQTATDSPSVKPNEL--EEESTPSIQTETLVQQEEPCEEEAEKATCDSDFAVETL 1165
            I++ E +    S   K +++   EE     +   + Q+EE  EE   +           +
Sbjct: 278  INKMEARPRRQSMKEKEHQVVRNEEQKAEQEEGKVAQREEELEETGNQHN--------DV 329

Query: 1166 ELETQGEEVKEEIPLVASASVSIEQFTENAEECALNQQMFNSDLEKKGAEIINPKTALLP 1225
            E+E  GEE ++EI +V S +   ++  E  +E  +  +      E +  +   P+  +  
Sbjct: 330  EIEEAGEEEEKEIAIVHSDAEKEQEEEEQKQEMEVKMEEETEVRESEKQQDSQPEEVM-- 387

Query: 1226 SDSVFAEERNLKGILEESPSEAEDFISGITQTMVEAVAEVEKNETVSEILPSTCIVTLVP 1285
               V     N+K ++ +      + +  +  +  EA  E+E  E   EI P     +L P
Sbjct: 388  --DVLEMVENVKHVIADQEVMETNRVESVEPSENEASKELEP-EMEFEIEPDKECKSLSP 444

Query: 1286 GIPTGDEKTVDKKNISEKKGNMD-EKEEKEFNTKETRMDLQIGTEKAEKNEGRMDAEKVE 1344
            G          K+N+S     +D EKE +E   KE+    +   +   +++ ++  +   
Sbjct: 445  G----------KENVSA----LDMEKESEEKEEKESEPQPEPVAQPQPQSQPQLQLQSQS 490

Query: 1345 KMAAMKEKPAEN---TLFKAYPNKGVGQANKPDETSKTSILAVSDVSSSKPSIKAVIVSS 1401
            +     + P++    +L    P   V Q  +     +     V  V  ++  ++ V+   
Sbjct: 491  QPVLQSQPPSQPEDLSLAVLQPTPQVTQ-EQGHLLPERKDFPVESVKLTEVPVEPVLTVH 549

Query: 1402 PKAKA---TVSKTENQKSFPKSVPRDQINAEKKLSAKEFGLLKPTSARSGLAESSSKFKP 1458
            P++K+   T S++  +     S  R + ++    S+        +S+ SG   SSS+   
Sbjct: 550  PESKSKTKTRSRSRGRARNKTSKSRSRSSSSSSSSSSSTSSSSGSSSSSG--SSSSRSSS 607

Query: 1459 TQSSLTRGGSGRISALQGKLSKLDYRDITK---QSQETEARPSI-MKRDDSNNKTLAEQN 1514
            + SS T G S R S+     S  + R  ++    +++ + R S+  KR D++    + ++
Sbjct: 608  SSSSSTSGSSSRDSS-SSTSSSSESRSRSRGRGHNRDRKHRRSVDRKRRDTSGLERSHKS 666

Query: 1515 TKNPKSTTGRSSKSK 1529
            +K   S   + SK K
Sbjct: 667  SKGGSSRDTKGSKDK 681



 Score = 34.7 bits (78), Expect = 0.95
 Identities = 41/160 (25%), Positives = 65/160 (40%), Gaps = 11/160 (6%)

Query: 471 SRRNEGNRKENETPRRRSHSPSPRRSRRSSSSHRFRRSRSPMHYMYRPRSRSPRICHRFI 530
           +R     R  N+T + RS S S   S  SS+S     S S      R  S S        
Sbjct: 558 TRSRSRGRARNKTSKSRSRSSSSSSSSSSSTSSSSGSSSSSGSSSSRSSSSSSSSTSGSS 617

Query: 531 SRYRSRSRSRSPY-RIRNPFRGSPKCFRSVSPERMSRRSVRSSDRKKALEDVVQRSGHGT 589
           SR  S S S S   R R+  RG  +           R+  RS DRK+     ++RS   +
Sbjct: 618 SRDSSSSTSSSSESRSRSRGRGHNR----------DRKHRRSVDRKRRDTSGLERSHKSS 667

Query: 590 EFNKQKHLEAADKGHSPAQKPKTSSGTKPSVKPTSATKSD 629
           +    +  + +   +S + + ++ S +  S K +S ++ D
Sbjct: 668 KGGSSRDTKGSKDKNSRSDRKRSISESSRSGKRSSRSERD 707



 Score = 32.3 bits (72), Expect = 4.7
 Identities = 45/172 (26%), Positives = 70/172 (40%), Gaps = 31/172 (18%)

Query: 1752 DEVTEEDEDSLADFNNLKEEL----NFVTVDEVGEEEDGDNDLKVELAQSKNDHPTDKKG 1807
            ++  E++E  +A      EE     N V ++E GEEE+ +  +    A+ + +    K+ 
Sbjct: 302  EQKAEQEEGKVAQREEELEETGNQHNDVEIEEAGEEEEKEIAIVHSDAEKEQEEEEQKQE 361

Query: 1808 NRKKRAVDTKKTKLESLSQVGPVNENVMEEDLKTMIE--RHLTAK---TPTKRV------ 1856
               K   +T+  + E      P  E VM  D+  M+E  +H+ A      T RV      
Sbjct: 362  MEVKMEEETEVRESEKQQDSQP--EEVM--DVLEMVENVKHVIADQEVMETNRVESVEPS 417

Query: 1857 --RIGKTLPSEKAVVTEPAK-------GEE---AFQMSEVDEESGLKDSEPE 1896
                 K L  E     EP K       G+E   A  M +  EE   K+SEP+
Sbjct: 418  ENEASKELEPEMEFEIEPDKECKSLSPGKENVSALDMEKESEEKEEKESEPQ 469


>gi|23111062 splicing factor, arginine/serine-rich 8 [Homo sapiens]
          Length = 951

 Score = 51.2 bits (121), Expect = 1e-05
 Identities = 40/106 (37%), Positives = 52/106 (49%), Gaps = 6/106 (5%)

Query: 469 LPS--RRNEGNRKENETPRRRSHSPSPRRSRRSSSSHRFRRSRSPMHYMYRPRSRSPRIC 526
           LPS  R    +R  + +PRRR+HSP  RR  RS  +  +R SRSP     R RSRSP   
Sbjct: 792 LPSAYRTVRRSRSRSRSPRRRAHSPERRREERSVPT-AYRVSRSPGASRKRTRSRSP--- 847

Query: 527 HRFISRYRSRSRSRSPYRIRNPFRGSPKCFRSVSPERMSRRSVRSS 572
           H    + RSRSR++S  R ++         R  +P   S  S   S
Sbjct: 848 HEKKKKRRSRSRTKSKARSQSVSPSKQAAPRPAAPAAHSAHSASVS 893



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 48/213 (22%), Positives = 79/213 (37%), Gaps = 18/213 (8%)

Query: 466 PEILPSRRNEGNRKENETPRRRSHSPSPRRSRRSSSSHRFRRSRSPMH------------ 513
           P+   S+  +  R+E +  +++ H    R   RS   H   +SRS  H            
Sbjct: 738 PDRPSSKSKDPPREEEKEKKKKKHKKRSRTRSRSPKYHSSSKSRSRSHSKAKHSLPSAYR 797

Query: 514 --YMYRPRSRSPRICHRFISRYRSRSRSRSPYRIRNPFRGSPKCFRSVSP-ERMSRRSVR 570
                R RSRSPR       R R      + YR+      S K  RS SP E+  +R  R
Sbjct: 798 TVRRSRSRSRSPRRRAHSPERRREERSVPTAYRVSRSPGASRKRTRSRSPHEKKKKRRSR 857

Query: 571 SSDRKKALEDVVQRSGHGTEFNKQKHLEAADKGHSPAQKPKTSSGTKPSVKPTSATKSDS 630
           S  + KA    V  S        +    AA   HS +  P  S G+        + + ++
Sbjct: 858 SRTKSKARSQSVSPSKQAA---PRPAAPAAHSAHSASVSPVESRGSSQERSRGVSQEKEA 914

Query: 631 NLGGHSIRCKSKNLEDDTLSECKQVSDKAVSLQ 663
            +    +      +  D +++ + +   + +LQ
Sbjct: 915 QISSAIVSSVQSKITQDLMAKVRAMLAASKNLQ 947



 Score = 37.4 bits (85), Expect = 0.15
 Identities = 86/401 (21%), Positives = 150/401 (37%), Gaps = 41/401 (10%)

Query: 1087 EVQIEHDPELEKESPGLKNSPIDESEV---------QTATDSPSVKPNELEEESTPSIQT 1137
            E   +  PE   ++ G   +P D +EV         + A+ S +V   +L + S   I  
Sbjct: 523  EAPTDSAPEKPSDA-GEDGAPEDAAEVGARAGSGGKKEASSSKTVPDGKLVKASFAPISF 581

Query: 1138 ETLVQQEE--PCEEEAEKATCDSDFAVETLELETQGEEVKEEIPLVASASVSIEQFTENA 1195
                ++ +  P E+   K   DSD   E+ E +          P VA   V +E+     
Sbjct: 582  AIKAKENDLLPLEKNRVKLDDDSDDDEESKEGQESSSSAANTNPAVAPPCVVVEEKKPQL 641

Query: 1196 EECALNQQMFNSDLEKKGAEIINPKTALLPSDSVFAEERNLKGILEESPSEAEDFISGIT 1255
             +  L  +     LE + A     K A    +S   +E+ L+    E   +A  F+  + 
Sbjct: 642  TQEELEAKQAKQKLEDRLAAAAREKLAQASKES---KEKQLQA---ERKRKAALFLQTLK 695

Query: 1256 QTMVEAVAEVEKNETVSEILPSTCIVTLVPG---IPTGDEKTVDKKNISEKKGNMDEKEE 1312
              + EA A   +    S    ST    L+ G   +PT + K  D+ +   K    +E++E
Sbjct: 696  NPLPEAEAGKIEESPFSVEESSTTPCPLLTGGRPLPTLEVKPPDRPSSKSKDPPREEEKE 755

Query: 1313 KEFNTKETRMDLQIGTEK---AEKNEGRMDAEKVEKMAAMKEKPAENTLFKAYPNKGVGQ 1369
            K+    + R   +  + K   + K+  R  ++    + +       +      P +   +
Sbjct: 756  KKKKKHKKRSRTRSRSPKYHSSSKSRSRSHSKAKHSLPSAYRTVRRSRSRSRSPRR---R 812

Query: 1370 ANKPDETSKTSILAVSDVSSSKP--SIKAVIVSSPKAKATVSKTENQKSFPKSVPRDQIN 1427
            A+ P+   +   +  +   S  P  S K     SP  K    K    +S  KS  R Q  
Sbjct: 813  AHSPERRREERSVPTAYRVSRSPGASRKRTRSRSPHEK---KKKRRSRSRTKSKARSQSV 869

Query: 1428 AEKKLSAKEFGLLKPTSARSGLAESSSKFKPTQSSLTRGGS 1468
            +  K +A      +P +  +  A S+S   P +S   RG S
Sbjct: 870  SPSKQAAP-----RPAAPAAHSAHSAS-VSPVES---RGSS 901


>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
            sapiens]
          Length = 1937

 Score = 51.2 bits (121), Expect = 1e-05
 Identities = 111/597 (18%), Positives = 232/597 (38%), Gaps = 81/597 (13%)

Query: 1431 KLSAKEFGLLKPTSARSGLAESSSKFKPTQSSLTRGGSGRISALQGKLSKLDYRDITKQS 1490
            KL  K   LLK       +A    +F+ T+  L +         + K  +L+ + +T   
Sbjct: 834  KLFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKS--------EAKRKELEEKMVTLLK 885

Query: 1491 QETEARPSIMKRDDS--NNKTLAEQNTKNPKSTTGR----SSKSKEEPLFPFNL------ 1538
            ++ + +  +    DS  + +   EQ  KN      +    + +++EE      L      
Sbjct: 886  EKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRK 945

Query: 1539 --DEFVTVDEVIEEVNPSQAKQNPLKGKRKETLKNVPFSELNLKKKKGKTSTPRGVEGEL 1596
              DE   + + I+++  + AK    K   +  +KN+      L +   K S  +    E 
Sbjct: 946  LEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQET 1005

Query: 1597 SFVTLDEIGEEEDAAAHLAQALVTVDEVIDEEELNMEEMVKNSNSLFTLDELIDQDDCIS 1656
               TLD++  EED    L +A   +++ +D+ E ++E+  K    L      ++ D  ++
Sbjct: 1006 HQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLA 1065

Query: 1657 HSEPKDVTVLSVAEEQDLLKQE----RLVTVDEIGEVEELPLNESADITFATLNTKGNEG 1712
                 D+       ++ L K+E     L++  E  +  E+ L +      A +   G E 
Sbjct: 1066 QESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEI 1125

Query: 1713 DTVRDSIGFISSQVPEDPSTLVTVDEIQDDSSDLHLVTLDEVTEEDEDSLADFNNLKEEL 1772
            +  R S      Q  +    L  + E  +++            E ++   A+F  L+ +L
Sbjct: 1126 EAERASRAKAEKQRSDLSRELEEISERLEEAGG----ATSAQVELNKKREAEFQKLRRDL 1181

Query: 1773 NFVTVD-----------------EVGEEEDGDNDLKVELAQSKNDHPTDKKG-NRKKRAV 1814
               T+                  E+GE+ D    +K +L + K++   +    +    A+
Sbjct: 1182 EEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAI 1241

Query: 1815 DTKKTKLESL--SQVGPVNENVMEEDLKTMIERHLTAKTPTKRVRIG---KTLPSEKAVV 1869
               K  LE +  S    V+E   +E+ +  +   LTA+    +   G   + L  + A+V
Sbjct: 1242 SKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALV 1301

Query: 1870 TEPAKGEEAFQMS------EVDEESGLKDS----------EPERKRKKTEDSSSGKSVAS 1913
            ++ ++ ++A          +++EE+  K++          + +  R++ E+   GK+   
Sbjct: 1302 SQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKA--- 1358

Query: 1914 DVPEELDFLVPKAGFFCPICSLFYSGEKAMTNHCKSTRHKQNTEKFMAKQRKEKEQN 1970
                EL   + KA        +     K  T+  + T   +  +K +A++ +E E++
Sbjct: 1359 ----ELQRALSKAN-----SEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEH 1406


>gi|109637771 calpastatin isoform l [Homo sapiens]
          Length = 654

 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 125/605 (20%), Positives = 237/605 (39%), Gaps = 55/605 (9%)

Query: 1353 PAENTLFKAYPNKGVGQANKPDETSKTSILAVSDVSSSKPSIKAVIVSSPKAKATVSKTE 1412
            P E    K  P K   Q+ KP    K +    S+ + +K ++       P  K+T     
Sbjct: 3    PTETKAVKTEPEKK-SQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTE---- 57

Query: 1413 NQKSFPKSVPRDQINAEKKLSAKEFGLLKPTSARSGLAESSSKFKPTQSSLTR--GGSGR 1470
                 PK+ P+D I+A  +  A    +      +    +S +   P +S   +  G SG 
Sbjct: 58   -----PKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGM 112

Query: 1471 ISALQGKLSKLDYRDITKQSQETEARPSIMKRDDSNNKTLAEQNTKNPKSTTGRSSKSKE 1530
             +AL   +  L   + T++   T   P +    D  + T  E+  K   +   +  +   
Sbjct: 113  DAALDDLIDTLGGPEETEEENTTYTGPEV---SDPMSSTYIEELGKREVTIPPKYRELLA 169

Query: 1531 EPLFPFNLDEFVTVDEVIEEVNPSQAKQNPLKGKRKETLKNVPFSELNLKKKKGKTSTPR 1590
            +P+ P +  + ++ D      +P+ A +   K +  E LK    S   ++         R
Sbjct: 170  KPIGPDDAIDALSSDFTCG--SPTAAGKKTEKEESTEVLK--AQSAGTVRSAAPPQEKKR 225

Query: 1591 GVEGELSFVTLDEIGEEEDAAAHLAQALVTVD----EVIDEEELNMEEMVKNSNSLFTLD 1646
             VE +      D+  E   A+    QA   +D    + +DE +   E++ K        D
Sbjct: 226  KVEKD---TMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGED----D 278

Query: 1647 ELIDQDDCISHSEPKDVTVLSVAEEQDLLKQERLVTVDEI------GEVEELPL--NESA 1698
            E I  +  +  +  KD   L    E+    +     +DE+       E +E P    E  
Sbjct: 279  ETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKT 338

Query: 1699 DITFATLNTKGNEGDTVRDSIGFISSQVPEDPSTLVTVDEIQDDSSDLHLVTLDEVTEED 1758
            + + A      +E    R S+  I S  PE P+TL     + DD+ +    +L +   + 
Sbjct: 339  EESKAAAPAPVSEA-VCRTSMCSIQSAPPE-PATL--KGTVPDDAVEALADSLGKKEADP 394

Query: 1759 EDSLADFNNLKEELNFVTVDEVGEEEDG-DNDLKVELAQSKNDHPTDKKGNRKKRAVDTK 1817
            ED     + +KE+      +++GE+E+    D ++E  + K+  P   K ++++    ++
Sbjct: 395  EDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSE 454

Query: 1818 KTKLESLSQ--VGPVNENVME-EDLKTMIE-RHLTAKTPTKRVRIG----KTLPSEKAVV 1869
               L++LS+   GP N + ++ ED K       + ++TP    + G     T  S+K + 
Sbjct: 455  DFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLD 514

Query: 1870 TEPAKGEEAF--QMSEVDEESGLKDSEPERKRKKTEDSSSGKSVASDVPEELDFLVPKAG 1927
                K  ++   +  + DE   ++D   E+ + +  D    +     +P E   L+   G
Sbjct: 515  DALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERD--DTIPPEYRHLLDDNG 572

Query: 1928 FFCPI 1932
               P+
Sbjct: 573  QDKPV 577


>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
           [Homo sapiens]
          Length = 624

 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 51/196 (26%), Positives = 77/196 (39%), Gaps = 23/196 (11%)

Query: 479 KENETPRRRSHSPSPRRSRRSSSSHRFRRSRSPMHYMYRPRSRSPRICHRFISRYRSRSR 538
           K NE    RS S +  +SR SS SH  RR RS   +  R  +RS        SR + R R
Sbjct: 299 KSNERKGGRSRSHTRSKSRSSSKSHS-RRKRSQSKHRSRSHNRSR-------SRQKDRRR 350

Query: 539 SRSPYRIRNPFRGSPKCFRSVSPERMSRRSVRSSDRKKALEDVVQRSGHGTEFNKQKHLE 598
           S+SP++ R+  R            R SR    S D++K   + ++      E +++K  E
Sbjct: 351 SKSPHKKRSKSR----------ERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKERE 400

Query: 599 AADKGHSPAQKPKTSSGTKPSVKPTSATKS-----DSNLGGHSIRCKSKNLEDDTLSECK 653
              +     ++ K     K   K     K      +        R K K  E D   E +
Sbjct: 401 REKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKERE 460

Query: 654 QVSDKAVSLQRKLRKE 669
           +   K +  +RK  K+
Sbjct: 461 KDRSKEIDEKRKKDKK 476



 Score = 38.9 bits (89), Expect = 0.050
 Identities = 49/208 (23%), Positives = 81/208 (38%), Gaps = 23/208 (11%)

Query: 443 QHQNTSTHIESCRQLRQQYPDWNPEILPSRRNEGNRKENETPRRRSHSPSPRRSRRSSSS 502
           + +    H +   + +++  D   E    R  E + K  +  + R+   S   SRRS SS
Sbjct: 434 EREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSS 493

Query: 503 HRFRRSRSPMHYMYRPRSRSPRICHRFISRYRSRSRSRSPYRIRNPFRGSPKCFRSVSPE 562
            R RR R       R  SRSPR      S+   R  SRSP         SP+       +
Sbjct: 494 SRERRRRRS-----RSSSRSPR-----TSKTIKRKSSRSP---------SPRSRNKKDKK 534

Query: 563 RMSRRSVRSSDRKKALEDVVQRSGHGTEFNKQKHLEAADKGHSPAQKPKTSSGTKPSVKP 622
           R   R   S  R++     +++S +  +  ++    +         K   SS +K  V  
Sbjct: 535 REKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSK-EVDD 593

Query: 623 TSATKSDSNLGGHSIRCKSKNLEDDTLS 650
             A +++ N   H+  C+   L ++ LS
Sbjct: 594 KDAPRTEENKIQHNGNCQ---LNEENLS 618



 Score = 35.4 bits (80), Expect = 0.56
 Identities = 56/240 (23%), Positives = 94/240 (39%), Gaps = 36/240 (15%)

Query: 1292 EKTVDKKNISEKKGNMDEKEEKE-----------FNTKETRMDLQIGTEKAEKNEGRMDA 1340
            EK  +K+ + EK    + + EKE              KE   D +   EK  + E   + 
Sbjct: 382  EKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEH 441

Query: 1341 EKVEKMAAMKEKPAENTLFKAYPNKGVGQANKPDETSKTSILAVS----DVSSSKPSIKA 1396
            EK       KE+  E    K   +K + +  K D+ S+T   + +      SSS+   + 
Sbjct: 442  EKDRDKEKEKEQDKEKEREKD-RSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRR 500

Query: 1397 VIVSSPKAKATVSKTENQKSFPKSVPRDQINAEKKLSAKEFGLLKPTSARSGLAESSSKF 1456
               SS ++  T SKT  +KS     PR +   +KK   +          R  ++E   + 
Sbjct: 501  RSRSSSRSPRT-SKTIKRKSSRSPSPRSRNKKDKKREKE----------RDHISERRERE 549

Query: 1457 KPTQSSLTRGGSGRISALQGKLSKLDYRDITKQSQETEARP--SIMKRDDSNNKTLAEQN 1514
            + T  S+ +  + R     GK  KL+    + + +E    P  S+ K  D  +    E+N
Sbjct: 550  RST--SMRKSSNDR----DGK-EKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEEN 602


>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
           [Homo sapiens]
          Length = 508

 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 51/196 (26%), Positives = 77/196 (39%), Gaps = 23/196 (11%)

Query: 479 KENETPRRRSHSPSPRRSRRSSSSHRFRRSRSPMHYMYRPRSRSPRICHRFISRYRSRSR 538
           K NE    RS S +  +SR SS SH  RR RS   +  R  +RS        SR + R R
Sbjct: 183 KSNERKGGRSRSHTRSKSRSSSKSHS-RRKRSQSKHRSRSHNRSR-------SRQKDRRR 234

Query: 539 SRSPYRIRNPFRGSPKCFRSVSPERMSRRSVRSSDRKKALEDVVQRSGHGTEFNKQKHLE 598
           S+SP++ R+  R            R SR    S D++K   + ++      E +++K  E
Sbjct: 235 SKSPHKKRSKSR----------ERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKERE 284

Query: 599 AADKGHSPAQKPKTSSGTKPSVKPTSATKS-----DSNLGGHSIRCKSKNLEDDTLSECK 653
              +     ++ K     K   K     K      +        R K K  E D   E +
Sbjct: 285 REKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKERE 344

Query: 654 QVSDKAVSLQRKLRKE 669
           +   K +  +RK  K+
Sbjct: 345 KDRSKEIDEKRKKDKK 360



 Score = 38.9 bits (89), Expect = 0.050
 Identities = 49/208 (23%), Positives = 81/208 (38%), Gaps = 23/208 (11%)

Query: 443 QHQNTSTHIESCRQLRQQYPDWNPEILPSRRNEGNRKENETPRRRSHSPSPRRSRRSSSS 502
           + +    H +   + +++  D   E    R  E + K  +  + R+   S   SRRS SS
Sbjct: 318 EREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSS 377

Query: 503 HRFRRSRSPMHYMYRPRSRSPRICHRFISRYRSRSRSRSPYRIRNPFRGSPKCFRSVSPE 562
            R RR R       R  SRSPR      S+   R  SRSP         SP+       +
Sbjct: 378 SRERRRRRS-----RSSSRSPR-----TSKTIKRKSSRSP---------SPRSRNKKDKK 418

Query: 563 RMSRRSVRSSDRKKALEDVVQRSGHGTEFNKQKHLEAADKGHSPAQKPKTSSGTKPSVKP 622
           R   R   S  R++     +++S +  +  ++    +         K   SS +K  V  
Sbjct: 419 REKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSK-EVDD 477

Query: 623 TSATKSDSNLGGHSIRCKSKNLEDDTLS 650
             A +++ N   H+  C+   L ++ LS
Sbjct: 478 KDAPRTEENKIQHNGNCQ---LNEENLS 502



 Score = 35.4 bits (80), Expect = 0.56
 Identities = 56/240 (23%), Positives = 94/240 (39%), Gaps = 36/240 (15%)

Query: 1292 EKTVDKKNISEKKGNMDEKEEKE-----------FNTKETRMDLQIGTEKAEKNEGRMDA 1340
            EK  +K+ + EK    + + EKE              KE   D +   EK  + E   + 
Sbjct: 266  EKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEH 325

Query: 1341 EKVEKMAAMKEKPAENTLFKAYPNKGVGQANKPDETSKTSILAVS----DVSSSKPSIKA 1396
            EK       KE+  E    K   +K + +  K D+ S+T   + +      SSS+   + 
Sbjct: 326  EKDRDKEKEKEQDKEKEREKD-RSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRR 384

Query: 1397 VIVSSPKAKATVSKTENQKSFPKSVPRDQINAEKKLSAKEFGLLKPTSARSGLAESSSKF 1456
               SS ++  T SKT  +KS     PR +   +KK   +          R  ++E   + 
Sbjct: 385  RSRSSSRSPRT-SKTIKRKSSRSPSPRSRNKKDKKREKE----------RDHISERRERE 433

Query: 1457 KPTQSSLTRGGSGRISALQGKLSKLDYRDITKQSQETEARP--SIMKRDDSNNKTLAEQN 1514
            + T  S+ +  + R     GK  KL+    + + +E    P  S+ K  D  +    E+N
Sbjct: 434  RST--SMRKSSNDR----DGK-EKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEEN 486


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 128/592 (21%), Positives = 218/592 (36%), Gaps = 53/592 (8%)

Query: 1094 PELEKESPGLKNSPIDESEVQTATDSPSVKPNELEEESTPSIQTETLVQQEEPCEEEAEK 1153
            PE   + P +      +SE +      S K   + EE T   Q    V +EE  E+EA++
Sbjct: 423  PEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEE--EKEAKE 480

Query: 1154 ATCDSDFAVETLELETQGEEVKEEIPLVASASVSIEQFTENAEECALNQQMFNSDLE--K 1211
                 +   E  E E  GEE  +  P   +AS   E  +   EE     +  + + E  K
Sbjct: 481  EEGKEEEGGEEEEAEG-GEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAK 539

Query: 1212 KGAEIINPKTALLPS--------DSVFAEERNLKGILE-ESPSEAEDFISGITQTMVEAV 1262
              AE+ +P+ A  P+        ++   E+   K   E +SP +A+       ++  EA 
Sbjct: 540  SPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAK 599

Query: 1263 AEVEKNETVSEILPSTCIVTLVPGIPTGDEKTVDKKNISEKKGNMDEKEEKEF--NTKET 1320
            +  +    V E   S          P  +E     +  S +K     KEE +     K  
Sbjct: 600  SPEKAKSPVKEEAKSPAEAKS----PVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSP 655

Query: 1321 RMDLQIGTEKAEKNEGRMDAEKVEKMAAMKEKPAENTLFKAYPNKGVGQANKPDETSKTS 1380
              +     EKA K+  + +A+  EK  +  +  A++      P K   +A  P++     
Sbjct: 656  EKEEAKSPEKA-KSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKE--EAKSPEKAKSPV 712

Query: 1381 ILAVSDVSSSKPSIKAVIVSSPKAKATVSKT----ENQKSFPKSVPRDQINAEKKLSAKE 1436
                     +K  +K    +  KAK+ V +     E  KS  K+   D  + E K  AKE
Sbjct: 713  KEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKE 772

Query: 1437 FGLLK----PTSARSGLAESSSKFKPTQSSLTRGGSGRISALQGKLSKLDYRDITKQSQE 1492
                     P  A+S + E     +  +S L         A + ++ K   ++  K   +
Sbjct: 773  EARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAK----APEKEIPK---KEEVKSPVK 825

Query: 1493 TEARPSIMKRDDSNNKTLAEQNTKNPKSTTGRSSKSKEEPLFPFNLDEFVTVDEVIEEVN 1552
             E +P  +K  +   K   E+    PK+   + SK +E P       +     +V E+  
Sbjct: 826  EEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAP------KKEAPKPKVEEKKE 879

Query: 1553 PS--QAKQNPLKGKRKET--LKNVPFSELNLKKKKGKTSTPRGVEGELSFVTLDEIGEEE 1608
            P+  + K++ ++ K++E    K VP  E   K+   K       + +       +  E +
Sbjct: 880  PAVEKPKESKVEAKKEEAEDKKKVPTPE---KEAPAKVEVKEDAKPKEKTEVAKK--EPD 934

Query: 1609 DAAAHLAQALVTVDEVIDEEELNMEEMVKNSNSLFTLDELIDQDDCISHSEP 1660
            DA A          E   E++   EE  K        +    +DD     EP
Sbjct: 935  DAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEP 986



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 97/435 (22%), Positives = 167/435 (38%), Gaps = 54/435 (12%)

Query: 1045 KAILQLDSPESAQSMYSFLKQNPQNIGDHMLTCSLSP-KIDLPEVQIEHDPELEKESPGL 1103
            K+  +  SPE A+S      ++P      +   + SP ++  PE + +   + E +SP  
Sbjct: 593  KSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPE-KAKSPTKEEAKSPEK 651

Query: 1104 KNSPIDE---------SEVQTATDSPSVKPNELEEESTPSIQTETLVQQEEPCEEEAEKA 1154
              SP  E         S V+    SP    + ++ E+    + ++ V++E    E+A+  
Sbjct: 652  AKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAK-- 709

Query: 1155 TCDSDFAVETLELETQGEEVKEEIPLVASASVSIEQFTENAEECALNQQMFNSDLEKKGA 1214
               S    E    E     VKEE      A   +++  ++ E+    ++    D++   A
Sbjct: 710  ---SPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEA 766

Query: 1215 EIINPKTALLPSDSVFAEERNLKGILEESPSEAEDFISGITQTMVEAVAEVEKNETVSEI 1274
            +    + A  P+D  F E+   K  ++E     E   S + +       E+ K E V   
Sbjct: 767  KTPAKEEARSPADK-FPEKA--KSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKS- 822

Query: 1275 LPSTCIVTLVPGIPTGDE--------KTVDKKNISEKKGNMDEKEEKEFNTKETRMDLQI 1326
                         P  +E        K   KK   EK     + EEK+ + KE     + 
Sbjct: 823  -------------PVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEA 869

Query: 1327 GTEKAE-KNEGRMDAEKVEKMAAMKEKPAEN----TLFKAYPNK-GVGQANKPDETSKTS 1380
               K E K E  ++  K  K+ A KE+  +     T  K  P K  V +  KP E ++ +
Sbjct: 870  PKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVA 929

Query: 1381 ILAVSDVSSSKPSIKAVIVSSPKAKATVSKTENQKSFPKSVPRDQINAEKKLSAKEFGLL 1440
                 D  + +PS  A      K +A   K + ++   K  P ++   E K    +  L 
Sbjct: 930  KKEPDDAKAKEPSKPA-----EKKEAAPEKKDTKEEKAKK-PEEKPKTEAKAKEDDKTLS 983

Query: 1441 K-PTSARSGLAESSS 1454
            K P+  ++  AE SS
Sbjct: 984  KEPSKPKAEKAEKSS 998



 Score = 45.1 bits (105), Expect = 7e-04
 Identities = 95/464 (20%), Positives = 167/464 (35%), Gaps = 42/464 (9%)

Query: 1082 KIDLPEVQIEHDPELEKESPGLKNSPIDESEVQTATDSPSVKPNELEEESTPSIQTETLV 1141
            ++  PE       E  K  P  K+   +E++      SP    +  +EE+    + ++  
Sbjct: 543  EVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPE 602

Query: 1142 QQEEPCEEEAEK-ATCDSDFAVETLELETQGEEVKEEIPLVASASVSIEQFTENAEECAL 1200
            + + P +EEA+  A   S    E           K + P    A  S E+     +E A 
Sbjct: 603  KAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAK-SPEKAKSPEKEEAK 661

Query: 1201 NQQMFNSDLEKKGAEIINPKTALLPSDSVFAEERNLKGILEE---SPSEAEDFISGITQT 1257
            + +   S ++   AE  +P+ A  P  +        K  ++E   SP +A+  +    ++
Sbjct: 662  SPEKAKSPVK---AEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKS 718

Query: 1258 MVEAVAEVEKNETVSEILPSTCIVTLVPGIPTGDE-KTVDKKNISEKKGNMDEK--EEKE 1314
              +A + V++     E   S          P  +E K+ +K    EK   +D K  E K 
Sbjct: 719  PEKAKSPVKEEAKTPEKAKS----------PVKEEAKSPEKAKSPEKAKTLDVKSPEAKT 768

Query: 1315 FNTKETRMDLQIGTEKAEK--NEGRMDAEKVEKMAAMKEKPAENTLFKAYPNKG-VGQAN 1371
               +E R       EKA+    E     EK +       K  E  + K    K  V +  
Sbjct: 769  PAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEE 828

Query: 1372 KPDETSKTSILAVSDVSSSKPSIKAVIVSSPKAKATVSKTENQKSFPKSVPRDQINAEKK 1431
            KP E           V   +P  KA      KA AT    E + S  +  P+ +    K 
Sbjct: 829  KPQE-----------VKVKEPPKKA---EEEKAPATPKTEEKKDSKKEEAPKKEAPKPKV 874

Query: 1432 LSAKEFGLLKPTSARSGLAESSSKFKPTQSSLTRGGSGRISALQGKLSKLDYRDITKQSQ 1491
               KE  + KP  ++    +  ++ K    +  +    ++   +    K       K+  
Sbjct: 875  EEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPD 934

Query: 1492 ETEA----RPSIMKRDDSNNKTLAEQNTKNPKSTTGRSSKSKEE 1531
            + +A    +P+  K      K   E+  K P+      +K+KE+
Sbjct: 935  DAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKED 978



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 88/455 (19%), Positives = 172/455 (37%), Gaps = 68/455 (14%)

Query: 470  PSRRNEGNRKENETP-RRRSHSPSPRRSRRSSSSHRFRRSRSPMHYMYRPRSRSPRICHR 528
            P +    +  E ++P +  + SP+  +S   + S     ++SP       +++SP     
Sbjct: 607  PVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSP------EKAKSPE---- 656

Query: 529  FISRYRSRSRSRSPYRIRNPFRGSPKCFRSVSPERMS---RRSVRSSDRKKALEDVVQRS 585
                   +  ++SP + ++P +   K     SPE+     +   +S ++ K+      +S
Sbjct: 657  -------KEEAKSPEKAKSPVKAEAK-----SPEKAKSPVKAEAKSPEKAKSPVKEEAKS 704

Query: 586  GHGTEFNKQKHLEAADKGHSPA-QKPKTSSGTKPSVKPT--SATKSDSNLGGHSIRCKSK 642
                +   ++  ++ +K  SP  ++ KT    K  VK    S  K+ S     ++  KS 
Sbjct: 705  PEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSP 764

Query: 643  NLEDDTLSECKQVSDKAVSLQRKLRKEQSLHYGSVLLITELPEDGCT--EEDVRKLFQPF 700
              +     E +  +DK     +   KE+           + PE   +  +ED +   +  
Sbjct: 765  EAKTPAKEEARSPADKFPEKAKSPVKEE----------VKSPEKAKSPLKEDAKAPEKEI 814

Query: 701  GKVNDVLIVPYRKEAYLEMEFKEAIT-AIMKYIETTPLTIKGKSVKICVPGKKKAQNKEV 759
             K  +V      +E   E++ KE    A  +    TP T + K  K     KK+A   +V
Sbjct: 815  PKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKV 874

Query: 760  KKKT-----------LESKKVSASTLKRDADASKAVEIVTSTSAAKTGQAKASVAKVNKS 808
            ++K            +E+KK  A   K+     K              + K  VAK    
Sbjct: 875  EEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPD 934

Query: 809  TGKSASSVKSVVTVAVKGNKASIKTAKSGGKKSLEAKKTGNVKNKDSNKPVTIPENSEIK 868
              K           A + +K + K   +  KK  + +K      K   KP T  +  E  
Sbjct: 935  DAK-----------AKEPSKPAEKKEAAPEKKDTKEEKA----KKPEEKPKTEAKAKEDD 979

Query: 869  TSIEVKATENCAKEAISDAALEATENEPLNKETEE 903
             ++  + ++  A++A   ++ +  +++P  K TE+
Sbjct: 980  KTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATED 1014



 Score = 41.6 bits (96), Expect = 0.008
 Identities = 156/775 (20%), Positives = 284/775 (36%), Gaps = 131/775 (16%)

Query: 1162 VETLELETQGEEVKEEIPLVASASVSIEQFTENAEECALNQQMFNSDLEKKG-AEIINPK 1220
            V T  + +  EE+ E    + + +  +E      +  +L +Q   S+LE +  A+I + +
Sbjct: 306  VNTDAMRSAQEEITEYRRQLQARTTELEALKSTKD--SLERQ--RSELEDRHQADIASYQ 361

Query: 1221 TALLPSDSVFAEERNLKGILEESPSEAEDFISGITQTMVEAVAE---VEKNETVSEILPS 1277
             A+   D   AE RN K  +     E +D ++      +E  A    +E  E      P 
Sbjct: 362  EAIQQLD---AELRNTKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPI 418

Query: 1278 TCIVTLVPGIPTGDEKTVDKKNISEKKGNMDEKEEKEF-----NTKETRMDLQIGTEKAE 1332
                +L  G+P     +   K  SE+K  + EK EKE       T+ET++  ++ TE+ E
Sbjct: 419  P--FSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEV-TEEEE 475

Query: 1333 KNEGRMDAEKVEKMAAMKEKPAENTLFKAYPNKGVGQANKPDETSKTSILAVSDVSSSKP 1392
            K E + +  K E+    +E        K+ P +   +A  P++ +K+    V + + S  
Sbjct: 476  K-EAKEEEGKEEEGGEEEEAEGGEEETKSPPAE---EAASPEKEAKSP---VKEEAKSPA 528

Query: 1393 SIKAVIVSSPKAKATVSKTENQKSFPKSV---PRDQINAEKKLSAKEFGLLKPTSARSGL 1449
              K+      K+ A V   E  KS  K     P +  + EK+ +     +  P  A+S  
Sbjct: 529  EAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPA 588

Query: 1450 AESSSKFKPTQSSLTRGGSGRISALQGKLSKLDYRDITKQSQETEARPSIMKRDDSNNKT 1509
             E +      +S        +  A     +K   ++  K   E ++      +  +  + 
Sbjct: 589  KEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKA--KSPTKEEA 646

Query: 1510 LAEQNTKNPKSTTGRSSKSKEEPLFPFNLDEFVTVDEVIEEVNPSQAKQNPLKGKRKETL 1569
             + +  K+P+    +S +  + P+               E  +P +AK +P+K + K   
Sbjct: 647  KSPEKAKSPEKEEAKSPEKAKSPV-------------KAEAKSPEKAK-SPVKAEAKSPE 692

Query: 1570 K-NVPFSELNLKKKKGKTSTPRGVEGELSFVTLDEIGEEEDAAAHLAQALVTVDEVID-- 1626
            K   P  E     +K K+               +E    E A + + +   T ++     
Sbjct: 693  KAKSPVKEEAKSPEKAKSPVK------------EEAKSPEKAKSPVKEEAKTPEKAKSPV 740

Query: 1627 EEELNMEEMVKNSNSLFTLDELIDQDDCISHSEPKDVTVLSVAEEQDLLKQERLVTVDEI 1686
            +EE    E  K+     TLD                   +   E +   K+E     D+ 
Sbjct: 741  KEEAKSPEKAKSPEKAKTLD-------------------VKSPEAKTPAKEEARSPADKF 781

Query: 1687 GEVEELPLNESADITFATLNTKGNEGDTVRDSIGFISSQVPEDPSTLVTVDEIQDDSSDL 1746
             E  + P+ E        + +       +++       ++P+       V E +      
Sbjct: 782  PEKAKSPVKEE-------VKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQE-- 832

Query: 1747 HLVTLDEVTEEDEDSLADFNNLKEELNFVTVDEVGEEEDGDNDLKVELAQSKNDHPTDKK 1806
              V + E  ++ E+  A      EE                 D K E A  K + P  K 
Sbjct: 833  --VKVKEPPKKAEEEKAPATPKTEE---------------KKDSKKEEAPKK-EAPKPKV 874

Query: 1807 GNRKKRAVDT-KKTKLESLSQVGPVNENVMEEDLKTMIERHLTAKTPTKRVRIGKTLPSE 1865
              +K+ AV+  K++K+E+  +          ED K         K PT      K  P+ 
Sbjct: 875  EEKKEPAVEKPKESKVEAKKEEA--------EDKK---------KVPTPE----KEAPA- 912

Query: 1866 KAVVTEPAKGEEAFQMS--EVDEESGLKDSEPERKRKKTEDSSSGKSVASDVPEE 1918
            K  V E AK +E  +++  E D+    + S+P  K++   +    K   +  PEE
Sbjct: 913  KVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEE 967



 Score = 38.9 bits (89), Expect = 0.050
 Identities = 120/614 (19%), Positives = 213/614 (34%), Gaps = 91/614 (14%)

Query: 751  KKKAQNKEVKKKT----LESKKVSASTLKRDADASKAVEIVTSTSAAKTGQAKASVAKVN 806
            +K+A+ +E K++      E++     T    A+ + + E    +   +  ++ A      
Sbjct: 475  EKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPE 534

Query: 807  KSTGKSASSVKSVVTVAVKGNKASIKTAKSGGKKSLEAKKTGNVKNKDSNKPVTIPENSE 866
            K   KS + VKS         + +    ++   +  EAK    VK+ +  K    P   E
Sbjct: 535  KEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKS---PAKEE 591

Query: 867  IKTSIEVKATENCAKEAISDAALEATENEPLNKETEEMCVMLVSNLPNKGYSVEEVYDLA 926
             K+  E K+ E  AK  + + A    E +   KE  +    + S    K  + EE     
Sbjct: 592  AKSPAEAKSPEK-AKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPE 650

Query: 927  KPFGGLKDILILSSHKKAYIEINRKAAESMVKFYTCFPVLMDGNQLSISMAPENMNIKDE 986
            K     K+        K+ ++   K+ E         PV  +      + +P     K  
Sbjct: 651  KAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKS-----PVKAEAKSPEKAKSPVKEEAKSP 705

Query: 987  EAIFITLVKE-NDPEANIDTIYDRFVHLDNLPEDGLQCVLCVGLQFGKVDHHVFISNRNK 1045
            E     + +E   PE     + +        PE     V                    K
Sbjct: 706  EKAKSPVKEEAKSPEKAKSPVKEEA----KTPEKAKSPV----------------KEEAK 745

Query: 1046 AILQLDSPESAQSMYSFLKQNPQNIGDHMLTCSLSPKIDLPEVQIEHDPELEKESPGLKN 1105
            +  +  SPE A+++     +      +     + SP    PE + +   + E +SP    
Sbjct: 746  SPEKAKSPEKAKTLDVKSPEAKTPAKEE----ARSPADKFPE-KAKSPVKEEVKSPEKAK 800

Query: 1106 SPIDESEVQTATDSPS---VKPNELEEESTPSIQTETLVQQEEPCEEEAEKATCDSDFAV 1162
            SP+ E       + P    VK    EEE    ++ +     E P + E EKA        
Sbjct: 801  SPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVK-----EPPKKAEEEKAPA------ 849

Query: 1163 ETLELETQGEEVKEEIPLVASASVSIEQFTENAEECALNQQMFNSDLEKKGAEIINPKTA 1222
             T + E + +  KEE P   +    +E+  E A E     +   S +E K  E  + K  
Sbjct: 850  -TPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVE-----KPKESKVEAKKEEAEDKKKV 903

Query: 1223 LLPSDSVFAEERNLKGILEESPSEAEDFISGITQTMVEAVAEVEKNETVSEILPSTCIVT 1282
              P               +E+P++ E          V+  A+ ++   V++  P      
Sbjct: 904  PTPE--------------KEAPAKVE----------VKEDAKPKEKTEVAKKEPDDAKAK 939

Query: 1283 LVPGIPTGDEKTVDKKNIS-EKKGNMDEKEEKEFNTKETRMDLQIGTEKAEKNEGRMDAE 1341
                      K  +KK  + EKK   +EK +K     +T    +   +   K   +  AE
Sbjct: 940  -------EPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAE 992

Query: 1342 KVEKMAAMKEKPAE 1355
            K EK ++  +K ++
Sbjct: 993  KAEKSSSTDQKDSK 1006


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.308    0.126    0.344 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 75,679,144
Number of Sequences: 37866
Number of extensions: 3751870
Number of successful extensions: 21031
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 109
Number of HSP's successfully gapped in prelim test: 631
Number of HSP's that attempted gapping in prelim test: 16185
Number of HSP's gapped (non-prelim): 4065
length of query: 1978
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1861
effective length of database: 13,817,196
effective search space: 25713801756
effective search space used: 25713801756
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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