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Search of human proteins with 21536378
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP),
member 11 [Homo sapiens]
(1321 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 2599 0.0
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 1287 0.0
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A... 1249 0.0
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B... 1242 0.0
gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C... 1193 0.0
gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo ... 775 0.0
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo... 334 3e-91
gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo ... 322 1e-87
gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member ... 318 3e-86
gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member... 318 3e-86
gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member ... 302 2e-81
gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Ho... 254 4e-67
gi|73747915 transporter 2, ATP-binding cassette, sub-family B is... 226 9e-59
gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo sa... 226 9e-59
gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor... 224 4e-58
gi|190343023 ATP-binding cassette, sub-family C, member 6 isofor... 221 3e-57
gi|239756495 PREDICTED: hypothetical protein [Homo sapiens] 219 2e-56
gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member... 218 4e-56
gi|21729873 ATP-binding cassette, sub-family C, member 11 isofor... 212 2e-54
gi|15149474 ATP-binding cassette, sub-family C, member 11 isofor... 212 2e-54
gi|73747917 transporter 2, ATP-binding cassette, sub-family B is... 206 2e-52
gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform... 205 3e-52
gi|110832837 ATP-binding cassette, sub-family C, member 9 isofor... 201 4e-51
gi|110832839 ATP-binding cassette, sub-family C, member 9 isofor... 199 2e-50
gi|110832835 ATP-binding cassette, sub-family C, member 9 isofor... 199 2e-50
gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform ... 198 2e-50
gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo s... 191 5e-48
gi|134142340 ATP-binding cassette, sub-family C, member 1 isofor... 189 2e-47
gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo ... 185 2e-46
gi|134142345 ATP-binding cassette, sub-family C, member 1 isofor... 174 7e-43
>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
[Homo sapiens]
Length = 1321
Score = 2599 bits (6736), Expect = 0.0
Identities = 1321/1321 (100%), Positives = 1321/1321 (100%)
Query: 1 MSDSVILRSIKKFGEENDGFESDKSYNNDKKSRLQDEKKGDGVRVGFFQLFRFSSSTDIW 60
MSDSVILRSIKKFGEENDGFESDKSYNNDKKSRLQDEKKGDGVRVGFFQLFRFSSSTDIW
Sbjct: 1 MSDSVILRSIKKFGEENDGFESDKSYNNDKKSRLQDEKKGDGVRVGFFQLFRFSSSTDIW 60
Query: 61 LMFVGSLCAFLHGIAQPGVLLIFGTMTDVFIDYDVELQELQIPGKACVNNTIVWTNSSLN 120
LMFVGSLCAFLHGIAQPGVLLIFGTMTDVFIDYDVELQELQIPGKACVNNTIVWTNSSLN
Sbjct: 61 LMFVGSLCAFLHGIAQPGVLLIFGTMTDVFIDYDVELQELQIPGKACVNNTIVWTNSSLN 120
Query: 121 QNMTNGTRCGLLNIESEMIKFASYYAGIAVAVLITGYIQICFWVIAAARQIQKMRKFYFR 180
QNMTNGTRCGLLNIESEMIKFASYYAGIAVAVLITGYIQICFWVIAAARQIQKMRKFYFR
Sbjct: 121 QNMTNGTRCGLLNIESEMIKFASYYAGIAVAVLITGYIQICFWVIAAARQIQKMRKFYFR 180
Query: 181 RIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWK 240
RIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWK
Sbjct: 181 RIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWK 240
Query: 241 LTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKRE 300
LTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKRE
Sbjct: 241 LTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKRE 300
Query: 301 VERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTPGTLV 360
VERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTPGTLV
Sbjct: 301 VERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTPGTLV 360
Query: 361 QIFLSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEI 420
QIFLSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEI
Sbjct: 361 QIFLSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEI 420
Query: 421 EFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVT 480
EFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVT
Sbjct: 421 EFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVT 480
Query: 481 VDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNF 540
VDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNF
Sbjct: 481 VDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNF 540
Query: 541 IMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEV 600
IMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEV
Sbjct: 541 IMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEV 600
Query: 601 LSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQSQG 660
LSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQSQG
Sbjct: 601 LSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQSQG 660
Query: 661 NQALNEEDIKDATEDDMLARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKST 720
NQALNEEDIKDATEDDMLARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKST
Sbjct: 661 NQALNEEDIKDATEDDMLARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKST 720
Query: 721 YEEDRKDKDIPVQEEVEPAPVRRILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQIL 780
YEEDRKDKDIPVQEEVEPAPVRRILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQIL
Sbjct: 721 YEEDRKDKDIPVQEEVEPAPVRRILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQIL 780
Query: 781 GTFSIPDKEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAML 840
GTFSIPDKEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAML
Sbjct: 781 GTFSIPDKEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAML 840
Query: 841 GQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKL 900
GQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKL
Sbjct: 841 GQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKL 900
Query: 901 SLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFI 960
SLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFI
Sbjct: 901 SLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFI 960
Query: 961 EALETELEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRV 1020
EALETELEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRV
Sbjct: 961 EALETELEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRV 1020
Query: 1021 ISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDF 1080
ISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDF
Sbjct: 1021 ISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDF 1080
Query: 1081 VDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMID 1140
VDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMID
Sbjct: 1081 VDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMID 1140
Query: 1141 GHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDF 1200
GHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDF
Sbjct: 1141 GHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDF 1200
Query: 1201 VMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVA 1260
VMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVA
Sbjct: 1201 VMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVA 1260
Query: 1261 LDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVTTGSPI 1320
LDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVTTGSPI
Sbjct: 1261 LDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVTTGSPI 1320
Query: 1321 S 1321
S
Sbjct: 1321 S 1321
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 1287 bits (3330), Expect = 0.0
Identities = 663/1306 (50%), Positives = 907/1306 (69%), Gaps = 42/1306 (3%)
Query: 14 GEENDGFESDKSYNNDKKSRLQDEKKGDGVRVGFFQLFRFSSSTDIWLMFVGSLCAFLHG 73
G+ N G + + + KS + +KK V F +FR+S+ D M VG+L A +HG
Sbjct: 5 GDRNGGAKKKNFFKLNNKS--EKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAIIHG 62
Query: 74 IAQPGVLLIFGTMTDVFIDYDVELQELQ--IPGKACVNNTIVWTNSSLNQNMTNGTRCGL 131
P ++L+FG MTD+F + L++L I ++ +N+T +
Sbjct: 63 AGLPLMMLVFGEMTDIFANAG-NLEDLMSNITNRSDINDTGFF----------------- 104
Query: 132 LNIESEMIKFASYYAGIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFD 191
+N+E +M ++A YY+GI VL+ YIQ+ FW +AA RQI K+RK +F IMR EIGWFD
Sbjct: 105 MNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFD 164
Query: 192 CNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPL 251
+ VGELNTR +DD++KIN+ I D++ +F Q M + GF++GF RGWKLTLVI+++SP+
Sbjct: 165 VHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPV 224
Query: 252 IGIGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFA 311
+G+ AA +S FTD EL AYAKAG VA+EV++++RTV AFGG+K+E+ERY KNL A
Sbjct: 225 LGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEA 284
Query: 312 QRWGIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGAL 371
+R GI+K I G + LI+ YALAFWYG+TLVL GEY+ G ++ +F SV++GA
Sbjct: 285 KRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLS-GEYSIGQVLTVFFSVLIGAF 343
Query: 372 NLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPS 431
++G ASP +EAFA R AA IF+ ID KP ID S+ G+K D IKG +EF NV F YPS
Sbjct: 344 SVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPS 403
Query: 432 RPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNI 491
R EVKIL LN+ ++ G+ ALVG SG GKST +QL+QR YDP EGMV+VDG DIR++N+
Sbjct: 404 RKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINV 463
Query: 492 QWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTL 551
++LR+ IG+V QEPVLF+TTIAENIRYGRE+ TM++I +A KEANAY+FIM LP +FDTL
Sbjct: 464 RFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTL 523
Query: 552 VGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTII 611
VGE G Q+SGGQKQR+AIARAL+RNPKILLLD ATSALD ESEA+VQ L K + G T I
Sbjct: 524 VGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTI 583
Query: 612 SVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQSQGNQALNEEDIKD 671
+AHRLSTVR AD I GF+ G VE+G H+EL++ KG+YF LVT+Q+ GN+ + E+ D
Sbjct: 584 VIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNE-VELENAAD 642
Query: 672 ATEDDMLARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKSTYEEDRK-DKDI 730
++ ++ A S + SL IR+RS + + + +DRK
Sbjct: 643 ESKSEIDALEMSSNDSRSSL---IRKRSTRR-------------SVRGSQAQDRKLSTKE 686
Query: 731 PVQEEVEPAPVRRILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQILGTFS-IPDKE 789
+ E + P RI+K + EWPY +VG A +NG + P +A +FS+I+G F+ I D E
Sbjct: 687 ALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPE 746
Query: 790 EQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDD 849
+R N LLF+A+G +S T FLQG+ F K+GE+LTKRLR FR+ML QD++WFDD
Sbjct: 747 TKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDD 806
Query: 850 LRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFP 909
+N+ GALTTRLA DA+QV+GA GS++ +I + N+ +II+F + W+L+L++L P
Sbjct: 807 PKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVP 866
Query: 910 FLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEK 969
+A++G + +ML+G A +DK+ LE G+I EA+ N RTV + +E++F L+
Sbjct: 867 IIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQV 926
Query: 970 PFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSAT 1029
P++ +++KA+I+G F+F Q +M+ + + +R+G YL++++ + F V V SAVV A
Sbjct: 927 PYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAM 986
Query: 1030 ALGRAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPS 1089
A+G+ S+ P YAKAKISAA ++++ P I Y+T G + +G + F + F YP+
Sbjct: 987 AVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPT 1046
Query: 1090 RPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNV 1149
RPD VL GLS+ + GQTLA VGSSGCGKST +QLLERFYDP GKV++DG + K++NV
Sbjct: 1047 RPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNV 1106
Query: 1150 QFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYE 1209
Q+LR+++GIVSQEP+LF CSI +NI YGDN++ + E ++ AAK+A +H F+ SLP KY
Sbjct: 1107 QWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYS 1166
Query: 1210 TNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRT 1269
T VG +G+QLS G+KQRIAIARA+VR P ILLLDEATSALDTESEK VQ ALDKAREGRT
Sbjct: 1167 TKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRT 1226
Query: 1270 CIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVT 1315
CIVIAHRLSTIQNAD+I V G V E GTH++L+AQKG Y+ +V+
Sbjct: 1227 CIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVS 1272
Score = 392 bits (1007), Expect = e-108
Identities = 224/619 (36%), Positives = 350/619 (56%), Gaps = 43/619 (6%)
Query: 45 VGFFQLFRFSSSTDIWLMFV-GSLCAFLHGIAQPGVLLIFGTMTDVFIDYDVELQELQIP 103
V F+++ + + + W FV G CA ++G QP +IF + VF D + Q
Sbjct: 695 VSFWRIMKLNLTE--WPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQ-- 750
Query: 104 GKACVNNTIVWTNSSLNQNMTNGTRCGLLNIESEMIKFASYYAGIAVAVLITGYIQICFW 163
NS+L F+ + + + IT ++Q +
Sbjct: 751 ------------NSNL---------------------FSLLFLALGIISFITFFLQGFTF 777
Query: 164 VIAAARQIQKMRKFYFRRIMRMEIGWFDC--NSVGELNTRFSDDINKINDAIADQMALFI 221
A +++R FR ++R ++ WFD N+ G L TR ++D ++ AI ++A+
Sbjct: 778 GKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVIT 837
Query: 222 QRMTSTICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVA 281
Q + + G ++ F GW+LTL+++++ P+I I +S + K +G +A
Sbjct: 838 QNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIA 897
Query: 282 DEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAF 341
E I + RTV + E++ Y ++L R +RK + G F +++ YA F
Sbjct: 898 TEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCF 957
Query: 342 WYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKP 401
+G+ LV + L+ +F +V+ GA+ +G S +A + +A I I++ P
Sbjct: 958 RFGAYLVAHKLMSFEDVLL-VFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTP 1016
Query: 402 IIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGK 461
+ID S +G + ++G + F V F+YP+RP++ +L L++ +K G+ ALVG SG GK
Sbjct: 1017 LIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGK 1076
Query: 462 STALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGRE 521
ST +QL++RFYDP G V +DG +I+ LN+QWLR +GIV QEP+LF +IAENI YG
Sbjct: 1077 STVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDN 1136
Query: 522 D--ATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKI 579
+ E+IV+AAKEAN + FI LP ++ T VG+ G Q+SGGQKQR+AIARAL+R P I
Sbjct: 1137 SRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHI 1196
Query: 580 LLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGT 639
LLLD ATSALD ESE +VQE L K + G T I +AHRLST++ AD I+ F++G E GT
Sbjct: 1197 LLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGT 1256
Query: 640 HEELLERKGVYFTLVTLQS 658
H++LL +KG+YF++V++Q+
Sbjct: 1257 HQQLLAQKGIYFSMVSVQA 1275
>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
[Homo sapiens]
Length = 1279
Score = 1249 bits (3232), Expect = 0.0
Identities = 648/1293 (50%), Positives = 875/1293 (67%), Gaps = 56/1293 (4%)
Query: 32 SRLQDEKKGDGVR-VGFFQLFRFSSSTDIWLMFVGSLCAFLHGIAQPGVLLIFGTMTDVF 90
S Q KK V+ +G LFR+S D M +G++ A HG P ++++FG MTD F
Sbjct: 26 SSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKF 85
Query: 91 IDYDVELQELQIPGKACVNNTIVWTNSSLNQNMTNGTRCGLLN----IESEMIKFASYYA 146
+D N N SL+ LLN +E EM ++A YY+
Sbjct: 86 VD--------------TAGNFSFPVNFSLS----------LLNPGKILEEEMTRYAYYYS 121
Query: 147 GIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDCNSVGELNTRFSDDI 206
G+ VL+ YIQ+ FW +AA RQI+K+R+ +F I+R EIGWFD N ELNTR +DDI
Sbjct: 122 GLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDI 181
Query: 207 NKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKF 266
+KI++ I D++ +F Q + + GF++GF RGWKLTLVI+++SP++G+ AA +S F
Sbjct: 182 SKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAF 241
Query: 267 TDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFT 326
+D EL AYAKAG VA+E + ++RTV AFGG+ +E+ERY+K+L A+ GI+K I
Sbjct: 242 SDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISM 301
Query: 327 GFVWCLIFLCYALAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATG 386
G + LI+ YALAFWYGSTLV+ + EYT G + +F S+++GA ++G A+PC++AFA
Sbjct: 302 GIAFLLIYASYALAFWYGSTLVISK-EYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANA 360
Query: 387 RAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIK 446
R AA IF+ ID P ID SE G+K D IKG +EF++V F YPSR VKIL LN+ ++
Sbjct: 361 RGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQ 420
Query: 447 PGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPV 506
G+ ALVG SG GKST +QLIQR YDP EG + +DG DIR+ N+ +LR+ IG+V QEPV
Sbjct: 421 SGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPV 480
Query: 507 LFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQR 566
LFSTTIAENI YGR + TM++I +A KEANAY FIM LPQ+FDTLVGE G Q+SGGQKQR
Sbjct: 481 LFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQR 540
Query: 567 VAIARALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTI 626
+AIARAL+RNPKILLLD ATSALD ESEA VQ L K + G T I +AHRLSTVR AD I
Sbjct: 541 IAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVI 600
Query: 627 IGFEHGTAVERGTHEELLERKGVYFTLVTLQSQGNQALNEE----DIKDATEDDMLARTF 682
GFE G VE+G+H EL++++GVYF LV +Q+ G+Q +EE D K AT M +
Sbjct: 601 AGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATR--MAPNGW 658
Query: 683 SRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKSTYEEDRKDKDIPVQEEVEPAPVR 742
++ S + +++ Q S V E D + ++P P
Sbjct: 659 KSRLFRHSTQKNLKNSQMCQKSLDV--------------ETDGLEANVP------PVSFL 698
Query: 743 RILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQILGTFSIPDKEEQRSQINGVCLLF 802
++LK + EWPY +VG+V A NG + P ++ +FS+I+ F D ++ + N L+F
Sbjct: 699 KVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIF 758
Query: 803 VAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTRLA 862
+ +G +S FT FLQG+ F K+GE+LT+RLR F+AML QD++WFDD +NS GAL+TRLA
Sbjct: 759 LFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLA 818
Query: 863 TDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTRML 922
TDA+QVQGA G+++ +I + N+ +II+F + W+L+L++L P +A+SG + ++L
Sbjct: 819 TDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLL 878
Query: 923 TGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANIYG 982
G A RDK+ LE G+I EA+ NIRTV + +ER+F +L P++ ++QKA+IYG
Sbjct: 879 AGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYG 938
Query: 983 FCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRAFSYTPSYA 1042
F+ +Q M+ + + +R+G YLI N + F V V SA+V A ALG A S+ P YA
Sbjct: 939 ITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYA 998
Query: 1043 KAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVS 1102
KAK+SAA F L +RQP I Y+ G K D F+G I F + F YP+R + VL GLS+
Sbjct: 999 KAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLE 1058
Query: 1103 ISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQE 1162
+ GQTLA VGSSGCGKST +QLLERFYDP G V++DG ++KK+NVQ+LR+ +GIVSQE
Sbjct: 1059 VKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQE 1118
Query: 1163 PVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRG 1222
P+LF CSI +NI YGDN++ + + +++AAK A +H F+ +LP KYET VG +G+QLS G
Sbjct: 1119 PILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGG 1178
Query: 1223 EKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQN 1282
+KQRIAIARA++R P+ILLLDEATSALDTESEK VQ ALDKAREGRTCIVIAHRLSTIQN
Sbjct: 1179 QKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQN 1238
Query: 1283 ADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVT 1315
AD+I V G V E GTH++L+AQKG Y+ +V+
Sbjct: 1239 ADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVS 1271
Score = 392 bits (1007), Expect = e-108
Identities = 229/653 (35%), Positives = 365/653 (55%), Gaps = 50/653 (7%)
Query: 22 SDKSYNNDKKSRLQDEKKGDGVR-----VGFFQLFRFSSSTDIWLMFV-GSLCAFLHGIA 75
+ K+ N + + + + DG+ V F ++ + + + W FV G++CA +G
Sbjct: 667 TQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTE--WPYFVVGTVCAIANGGL 724
Query: 76 QPGVLLIFGTMTDVFIDYDVELQELQIPGKACVNNTIVWTNSSLNQNMTNGTRCGLLNIE 135
QP +IF + +F PG V +C +
Sbjct: 725 QPAFSVIFSEIIAIFG-----------PGDDAVKQQ----------------KCNI---- 753
Query: 136 SEMIKFASYYAGIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDC--N 193
F+ + + + T ++Q + A +++R F+ ++R ++ WFD N
Sbjct: 754 -----FSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKN 808
Query: 194 SVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIG 253
S G L+TR + D ++ A ++AL Q + + G ++ F GW+LTL++++V P+I
Sbjct: 809 STGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIA 868
Query: 254 IGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQR 313
+ ++ + K AG +A E I ++RTV + E++ Y + L R
Sbjct: 869 VSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYR 928
Query: 314 WGIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNL 373
++K + G ++ YA F +G+ L+++ G ++ +F +++ GA+ L
Sbjct: 929 NSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVN-GHMRFRDVILVFSAIVFGAVAL 987
Query: 374 GNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRP 433
G+AS +A + +A +F +R+P+ID SE+G K D+ +G I F+ V F+YP+R
Sbjct: 988 GHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRA 1047
Query: 434 EVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQW 493
V +L L++ +K G+ ALVG SG GKST +QL++RFYDP G V +DG + + LN+QW
Sbjct: 1048 NVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQW 1107
Query: 494 LRDQIGIVEQEPVLFSTTIAENIRYGRED--ATMEDIVQAAKEANAYNFIMDLPQQFDTL 551
LR Q+GIV QEP+LF +IAENI YG + ++IV AAK AN + FI LP +++T
Sbjct: 1108 LRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETR 1167
Query: 552 VGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTII 611
VG+ G Q+SGGQKQR+AIARALIR P+ILLLD ATSALD ESE +VQE L K + G T I
Sbjct: 1168 VGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCI 1227
Query: 612 SVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQSQGNQAL 664
+AHRLST++ AD I+ F++G E GTH++LL +KG+YF++V++Q+ G Q L
Sbjct: 1228 VIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA-GTQNL 1279
>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
[Homo sapiens]
Length = 1286
Score = 1242 bits (3214), Expect = 0.0
Identities = 648/1300 (49%), Positives = 875/1300 (67%), Gaps = 63/1300 (4%)
Query: 32 SRLQDEKKGDGVR-VGFFQLFRFSSSTDIWLMFVGSLCAFLHGIAQPGVLLIFGTMTDVF 90
S Q KK V+ +G LFR+S D M +G++ A HG P ++++FG MTD F
Sbjct: 26 SSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKF 85
Query: 91 IDYDVELQELQIPGKACVNNTIVWTNSSLNQNMTNGTRCGLLN----IESEMIKFASYYA 146
+D N N SL+ LLN +E EM ++A YY+
Sbjct: 86 VD--------------TAGNFSFPVNFSLS----------LLNPGKILEEEMTRYAYYYS 121
Query: 147 GIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDCNSVGELNTRFSDDI 206
G+ VL+ YIQ+ FW +AA RQI+K+R+ +F I+R EIGWFD N ELNTR +DDI
Sbjct: 122 GLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDI 181
Query: 207 NKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKF 266
+KI++ I D++ +F Q + + GF++GF RGWKLTLVI+++SP++G+ AA +S F
Sbjct: 182 SKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAF 241
Query: 267 TDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFT 326
+D EL AYAKAG VA+E + ++RTV AFGG+ +E+ERY+K+L A+ GI+K I
Sbjct: 242 SDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISM 301
Query: 327 GFVWCLIFLCYALAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATG 386
G + LI+ YALAFWYGSTLV+ + EYT G + +F S+++GA ++G A+PC++AFA
Sbjct: 302 GIAFLLIYASYALAFWYGSTLVISK-EYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANA 360
Query: 387 RAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIK 446
R AA IF+ ID P ID SE G+K D IKG +EF++V F YPSR VKIL LN+ ++
Sbjct: 361 RGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQ 420
Query: 447 PGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPV 506
G+ ALVG SG GKST +QLIQR YDP EG + +DG DIR+ N+ +LR+ IG+V QEPV
Sbjct: 421 SGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPV 480
Query: 507 LFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQR 566
LFSTTIAENI YGR + TM++I +A KEANAY FIM LPQ+FDTLVGE G Q+SGGQKQR
Sbjct: 481 LFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQR 540
Query: 567 VAIARALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTI 626
+AIARAL+RNPKILLLD ATSALD ESEA VQ L K + G T I +AHRLSTVR AD I
Sbjct: 541 IAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVI 600
Query: 627 IGFEHGTAVERGTHEELLERKGVYFTLVTLQSQGNQALNEE----DIKDATEDDMLARTF 682
GFE G VE+G+H EL++++GVYF LV +Q+ G+Q +EE D K AT M +
Sbjct: 601 AGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATR--MAPNGW 658
Query: 683 SRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKSTYEEDRKDKDIPVQEEVEPAPVR 742
++ S + +++ Q S V E D + ++P P
Sbjct: 659 KSRLFRHSTQKNLKNSQMCQKSLDV--------------ETDGLEANVP------PVSFL 698
Query: 743 RILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQILGTFSIPDKEEQRSQINGVCLLF 802
++LK + EWPY +VG+V A NG + P ++ +FS+I+ F D ++ + N L+F
Sbjct: 699 KVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIF 758
Query: 803 VAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTRLA 862
+ +G +S FT FLQG+ F K+GE+LT+RLR F+AML QD++WFDD +NS GAL+TRLA
Sbjct: 759 LFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLA 818
Query: 863 TDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTRML 922
TDA+QVQGA G+++ +I + N+ +II+F + W+L+L++L P +A+SG + ++L
Sbjct: 819 TDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLL 878
Query: 923 TGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANIYG 982
G A RDK+ LE G+I EA+ NIRTV + +ER+F +L P++ ++QKA+IYG
Sbjct: 879 AGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYG 938
Query: 983 FCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRAFSYTPSYA 1042
F+ +Q M+ + + +R+G YLI N + F V V SA+V A ALG A S+ P YA
Sbjct: 939 ITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYA 998
Query: 1043 KAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVS 1102
KAK+SAA F L +RQP I Y+ G K D F+G I F + F YP+R + VL GLS+
Sbjct: 999 KAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLE 1058
Query: 1103 ISPGQTLAFVGSSGCGKSTSIQLLERFYDP-------DQGKVMIDGHDSKKVNVQFLRSN 1155
+ GQTLA VGSSGCGKST +QLLERFYDP D G ++DG ++KK+NVQ+LR+
Sbjct: 1059 VKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQ 1118
Query: 1156 IGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQ 1215
+GIVSQEP+LF CSI +NI YGDN++ + + +++AAK A +H F+ +LP KYET VG +
Sbjct: 1119 LGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDK 1178
Query: 1216 GSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAH 1275
G+QLS G+KQRIAIARA++R P+ILLLDEATSALDTESEK VQ ALDKAREGRTCIVIAH
Sbjct: 1179 GTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAH 1238
Query: 1276 RLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVT 1315
RLSTIQNAD+I V G V E GTH++L+AQKG Y+ +V+
Sbjct: 1239 RLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVS 1278
Score = 386 bits (991), Expect = e-107
Identities = 230/660 (34%), Positives = 365/660 (55%), Gaps = 57/660 (8%)
Query: 22 SDKSYNNDKKSRLQDEKKGDGVR-----VGFFQLFRFSSSTDIWLMFV-GSLCAFLHGIA 75
+ K+ N + + + + DG+ V F ++ + + + W FV G++CA +G
Sbjct: 667 TQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTE--WPYFVVGTVCAIANGGL 724
Query: 76 QPGVLLIFGTMTDVFIDYDVELQELQIPGKACVNNTIVWTNSSLNQNMTNGTRCGLLNIE 135
QP +IF + +F PG V +C +
Sbjct: 725 QPAFSVIFSEIIAIFG-----------PGDDAVKQQ----------------KCNI---- 753
Query: 136 SEMIKFASYYAGIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDC--N 193
F+ + + + T ++Q + A +++R F+ ++R ++ WFD N
Sbjct: 754 -----FSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKN 808
Query: 194 SVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIG 253
S G L+TR + D ++ A ++AL Q + + G ++ F GW+LTL++++V P+I
Sbjct: 809 STGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIA 868
Query: 254 IGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQR 313
+ ++ + K AG +A E I ++RTV + E++ Y + L R
Sbjct: 869 VSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYR 928
Query: 314 WGIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNL 373
++K + G ++ YA F +G+ L+++ G ++ +F +++ GA+ L
Sbjct: 929 NSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVN-GHMRFRDVILVFSAIVFGAVAL 987
Query: 374 GNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRP 433
G+AS +A + +A +F +R+P+ID SE+G K D+ +G I F+ V F+YP+R
Sbjct: 988 GHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRA 1047
Query: 434 EVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVD-------GHDI 486
V +L L++ +K G+ ALVG SG GKST +QL++RFYDP G V VD G +
Sbjct: 1048 NVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEA 1107
Query: 487 RSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGRED--ATMEDIVQAAKEANAYNFIMDL 544
+ LN+QWLR Q+GIV QEP+LF +IAENI YG + ++IV AAK AN + FI L
Sbjct: 1108 KKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETL 1167
Query: 545 PQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEVLSKI 604
P +++T VG+ G Q+SGGQKQR+AIARALIR P+ILLLD ATSALD ESE +VQE L K
Sbjct: 1168 PHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKA 1227
Query: 605 QHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQSQGNQAL 664
+ G T I +AHRLST++ AD I+ F++G E GTH++LL +KG+YF++V++Q+ G Q L
Sbjct: 1228 REGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA-GTQNL 1286
>gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C
[Homo sapiens]
Length = 1232
Score = 1193 bits (3086), Expect = 0.0
Identities = 634/1293 (49%), Positives = 851/1293 (65%), Gaps = 103/1293 (7%)
Query: 32 SRLQDEKKGDGVR-VGFFQLFRFSSSTDIWLMFVGSLCAFLHGIAQPGVLLIFGTMTDVF 90
S Q KK V+ +G LFR+S D M +G++ A HG P ++++FG MTD F
Sbjct: 26 SSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKF 85
Query: 91 IDYDVELQELQIPGKACVNNTIVWTNSSLNQNMTNGTRCGLLN----IESEMIKFASYYA 146
+D N N SL+ LLN +E EM ++A YY+
Sbjct: 86 VD--------------TAGNFSFPVNFSLS----------LLNPGKILEEEMTRYAYYYS 121
Query: 147 GIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDCNSVGELNTRFSDDI 206
G+ VL+ YIQ+ FW +AA RQI+K+R+ +F I+R EIGWFD N ELNTR +DDI
Sbjct: 122 GLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDI 181
Query: 207 NKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKF 266
+KI++ I D++ +F Q + + GF++GF RGWKLTLVI+++SP++G+ AA +S F
Sbjct: 182 SKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAF 241
Query: 267 TDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFT 326
+D EL AYAKAG VA+E + ++RTV AFGG+ +E+ERY+K+L A+ GI+K I
Sbjct: 242 SDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISM 301
Query: 327 GFVWCLIFLCYALAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATG 386
G + LI+ YALAFWYGSTLV+ + EYT G + +F S+++GA ++G A+PC++AFA
Sbjct: 302 GIAFLLIYASYALAFWYGSTLVISK-EYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANA 360
Query: 387 RAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIK 446
R AA IF+ ID P ID SE G+K D IKG +EF++V F YPSR VKIL LN+ ++
Sbjct: 361 RGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQ 420
Query: 447 PGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPV 506
G+ ALVG SG GKST +QLIQR YDP EG + +DG DIR+ N+ +LR+ IG+V QEPV
Sbjct: 421 SGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPV 480
Query: 507 LFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQR 566
LFSTTIAENI YGR + TM++I +A KEANAY FIM LPQ+FDTLVGE G Q+SGGQKQR
Sbjct: 481 LFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQR 540
Query: 567 VAIARALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTI 626
+AIARAL+RNPKILLLD ATSALD ESEA VQ L K + G T I +AHRLSTVR AD I
Sbjct: 541 IAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVI 600
Query: 627 IGFEHGTAVERGTHEELLERKGVYFTLVTLQSQGNQALNEE----DIKDATEDDMLARTF 682
GFE G VE+G+H EL++++GVYF LV +Q+ G+Q +EE D K AT M +
Sbjct: 601 AGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATR--MAPNGW 658
Query: 683 SRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKSTYEEDRKDKDIPVQEEVEPAPVR 742
++ S + +++ Q S V E D + ++P P
Sbjct: 659 KSRLFRHSTQKNLKNSQMCQKSLDV--------------ETDGLEANVP------PVSFL 698
Query: 743 RILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQILGTFSIPDKEEQRSQINGVCLLF 802
++LK + EWPY +VG+V A NG + P ++ +FS+I+ F D ++ + N L+F
Sbjct: 699 KVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIF 758
Query: 803 VAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTRLA 862
+ +G +S FT FLQG+ F K+GE+LT+RLR F+AML QD++WFDD +NS GAL+TRLA
Sbjct: 759 LFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLA 818
Query: 863 TDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTRML 922
TDA+QVQGA G+++ +I + N+ +II+F + W+L+L++L P +A+SG + ++L
Sbjct: 819 TDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLL 878
Query: 923 TGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANIYG 982
G A RDK+ LE G+I EA+ NIRTV + +ER+F E++ E +YG
Sbjct: 879 AGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKF-ESMYVE------------KLYG 925
Query: 983 FCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRAFSYTPSYA 1042
+RV SA+V A ALG A S+ P YA
Sbjct: 926 ----------------------------------PYRVFSAIVFGAVALGHASSFAPDYA 951
Query: 1043 KAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVS 1102
KAK+SAA F L +RQP I Y+ G K D F+G I F + F YP+R + VL GLS+
Sbjct: 952 KAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLE 1011
Query: 1103 ISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQE 1162
+ GQTLA VGSSGCGKST +QLLERFYDP G V++DG ++KK+NVQ+LR+ +GIVSQE
Sbjct: 1012 VKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQE 1071
Query: 1163 PVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRG 1222
P+LF CSI +NI YGDN++ + + +++AAK A +H F+ +LP KYET VG +G+QLS G
Sbjct: 1072 PILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGG 1131
Query: 1223 EKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQN 1282
+KQRIAIARA++R P+ILLLDEATSALDTESEK VQ ALDKAREGRTCIVIAHRLSTIQN
Sbjct: 1132 QKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQN 1191
Query: 1283 ADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVT 1315
AD+I V G V E GTH++L+AQKG Y+ +V+
Sbjct: 1192 ADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVS 1224
Score = 416 bits (1069), Expect = e-116
Identities = 227/586 (38%), Positives = 347/586 (59%), Gaps = 23/586 (3%)
Query: 754 YMLVGSVGAAVNGTVTPLYAFLFSQIL-------GTFSIPDK---------EEQRSQING 797
+M +G++ A +G+ PL +F ++ G FS P + ++
Sbjct: 56 FMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTR 115
Query: 798 VCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGAL 857
+ +G L ++Q + + +++R+ F A+L Q+I WFD N L
Sbjct: 116 YAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDI--NDTTEL 173
Query: 858 TTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGAT 917
TRL D S++ G ++GM + I+ F WKL+LVI+ P L LS A
Sbjct: 174 NTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAV 233
Query: 918 QTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQK 977
++L+ F+ ++ A G + EAL IRTV G + + +E + LE + I+K
Sbjct: 234 WAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKK 293
Query: 978 ANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRAFSY 1037
A A +++ + + ++ YG L+ ++ V ++++ A ++G+A
Sbjct: 294 AISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPC 353
Query: 1038 TPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLN 1097
++A A+ +A F ++D P I ++ G K D+ +G ++F D F+YPSR + ++L
Sbjct: 354 IDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILK 413
Query: 1098 GLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIG 1157
GL++ + GQT+A VGSSGCGKST++QL++R YDPD+G + IDG D + NV +LR IG
Sbjct: 414 GLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIG 473
Query: 1158 IVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGS 1217
+VSQEPVLF+ +I +NI YG + M+ + A K+A ++F+M LP+K++T VG +G+
Sbjct: 474 VVSQEPVLFSTTIAENICYGRG--NVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGA 531
Query: 1218 QLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRL 1277
QLS G+KQRIAIARA+VR+PKILLLDEATSALDTESE VQ ALDKAREGRT IVIAHRL
Sbjct: 532 QLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRL 591
Query: 1278 STIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLV---TTGSPI 1320
ST++NAD+IA GV++E+G+H ELM ++G Y+KLV T+GS I
Sbjct: 592 STVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQI 637
Score = 363 bits (931), Expect = e-100
Identities = 222/653 (33%), Positives = 347/653 (53%), Gaps = 97/653 (14%)
Query: 22 SDKSYNNDKKSRLQDEKKGDGVR-----VGFFQLFRFSSSTDIWLMFV-GSLCAFLHGIA 75
+ K+ N + + + + DG+ V F ++ + + + W FV G++CA +G
Sbjct: 667 TQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTE--WPYFVVGTVCAIANGGL 724
Query: 76 QPGVLLIFGTMTDVFIDYDVELQELQIPGKACVNNTIVWTNSSLNQNMTNGTRCGLLNIE 135
QP +IF + +F PG V +C +
Sbjct: 725 QPAFSVIFSEIIAIFG-----------PGDDAVKQQ----------------KCNI---- 753
Query: 136 SEMIKFASYYAGIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDC--N 193
F+ + + + T ++Q + A +++R F+ ++R ++ WFD N
Sbjct: 754 -----FSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKN 808
Query: 194 SVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIG 253
S G L+TR + D ++ A ++AL Q + + G ++ F GW+LTL++++V P+I
Sbjct: 809 STGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIA 868
Query: 254 IGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQR 313
+ ++ + K AG +A E I ++RTV + E++ Y + L
Sbjct: 869 VSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLY---- 924
Query: 314 WGIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNL 373
G Y ++F +++ GA+ L
Sbjct: 925 --------------------------------------GPY------RVFSAIVFGAVAL 940
Query: 374 GNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRP 433
G+AS +A + +A +F +R+P+ID SE+G K D+ +G I F+ V F+YP+R
Sbjct: 941 GHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRA 1000
Query: 434 EVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQW 493
V +L L++ +K G+ ALVG SG GKST +QL++RFYDP G V +DG + + LN+QW
Sbjct: 1001 NVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQW 1060
Query: 494 LRDQIGIVEQEPVLFSTTIAENIRYGRED--ATMEDIVQAAKEANAYNFIMDLPQQFDTL 551
LR Q+GIV QEP+LF +IAENI YG + ++IV AAK AN + FI LP +++T
Sbjct: 1061 LRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETR 1120
Query: 552 VGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTII 611
VG+ G Q+SGGQKQR+AIARALIR P+ILLLD ATSALD ESE +VQE L K + G T I
Sbjct: 1121 VGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCI 1180
Query: 612 SVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQSQGNQAL 664
+AHRLST++ AD I+ F++G E GTH++LL +KG+YF++V++Q+ G Q L
Sbjct: 1181 VIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA-GTQNL 1232
>gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo
sapiens]
Length = 812
Score = 775 bits (2000), Expect = 0.0
Identities = 400/838 (47%), Positives = 564/838 (67%), Gaps = 29/838 (3%)
Query: 481 VDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNF 540
VD +DIR+LN++ RD IG+V QEPVLF TTI+ NI+YGR+D T E++ +AA+EANAY+F
Sbjct: 2 VDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDF 61
Query: 541 IMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEV 600
IM+ P +F+TLVGE G QMSGGQKQR+AIARAL+RNPKIL+LD ATSALD+ES++ VQ
Sbjct: 62 IMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAA 121
Query: 601 LSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQSQG 660
L K G T I VAHRLST+R+AD I+ + G E+G H EL+ ++G+Y++LV Q
Sbjct: 122 LEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQ--- 178
Query: 661 NQALNEEDIKDATEDDMLARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKST 720
DIK A E M + T+S +SL + KS D
Sbjct: 179 -------DIKKADEQ-MESMTYSTERKTNSLPLHSVKSIKS--------------DFIDK 216
Query: 721 YEEDRKDKDIPVQEEVEPAPVRRILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQIL 780
EE + K+I + E + +ILK + PEWP++++G++ + +NGTV P+++ +F++I+
Sbjct: 217 AEESTQSKEISLPE----VSLLKILKLNKPEWPFVVLGTLASVLNGTVHPVFSIIFAKII 272
Query: 781 GTFSIPDKEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAML 840
F DK + ++FV +G + + F+QG + ++GE+LT RLR F+AML
Sbjct: 273 TMFGNNDKTTLKHDAEIYSMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAML 332
Query: 841 GQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKL 900
QDIAWFD+ NS G LTT LA D +Q+QGA GS+IG++ + TN+ +++II+F + W++
Sbjct: 333 YQDIAWFDEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEM 392
Query: 901 SLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFI 960
+ +IL P LA++G +T +TGFA++DKQ L+ G+I EAL NIRT+ + +E+ F
Sbjct: 393 TFLILSIAPVLAVTGMIETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFE 452
Query: 961 EALETELEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRV 1020
+ E L+ + +KA I G C+AF+ ++ A +A +R+G YLI + +F V
Sbjct: 453 QMYEEMLQTQHRNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIV 512
Query: 1021 ISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDF 1080
+A+ A A+G P Y+KAK AA F LL+++P I + G+K D +G ++F
Sbjct: 513 FTAIAYGAMAIGETLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTCEGNLEF 572
Query: 1081 VDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMID 1140
+ F YP RPD +L GLS+SI G+T+AFVGSSGCGKSTS+QLL+R YDP QG+V+ D
Sbjct: 573 REVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFD 632
Query: 1141 GHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDF 1200
G D+K++NVQ+LRS I IV QEPVLF CSI +NI YGDN++ +P++ + AA A +H F
Sbjct: 633 GVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSF 692
Query: 1201 VMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVA 1260
+ LPEKY T VG +G+QLS G+KQR+AIARA+++ PKILLLDEATSALD +SEK VQ A
Sbjct: 693 IEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHA 752
Query: 1261 LDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVTTGS 1318
LDKAR GRTC+V+ HRLS IQNAD+I V+ G + E+GTH+EL+ + Y+KLV S
Sbjct: 753 LDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNAQS 810
Score = 367 bits (943), Expect = e-101
Identities = 197/522 (37%), Positives = 308/522 (59%), Gaps = 5/522 (0%)
Query: 141 FASYYAGIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDC--NSVGEL 198
++ + + V ++ ++Q F+ A ++R F+ ++ +I WFD NS G L
Sbjct: 290 YSMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGL 349
Query: 199 NTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIGIGAAT 258
T + DI +I A ++ + Q T+ ++ F GW++T +I+S++P++ +
Sbjct: 350 TTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMI 409
Query: 259 IGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRK 318
+++ F + + + AG +A E + ++RT+ + EK + YE+ L R +K
Sbjct: 410 ETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSKK 469
Query: 319 GIVMGFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLGNASP 378
++G F I+ YA F +G+ L+ G TP + +F ++ GA+ +G
Sbjct: 470 AQIIGSCYAFSHAFIYFAYAAGFRFGAYLI-QAGRMTPEGMFIVFTAIAYGAMAIGETLV 528
Query: 379 CLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKIL 438
++ ++ A +F +++KP ID S++G K D +G +EF V+F YP RP+V IL
Sbjct: 529 LAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTCEGNLEFREVSFFYPCRPDVFIL 588
Query: 439 NDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQI 498
L++ I+ G+ A VG SG GKST++QL+QR YDP +G V DG D + LN+QWLR QI
Sbjct: 589 RGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQI 648
Query: 499 GIVEQEPVLFSTTIAENIRYGRED--ATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGG 556
IV QEPVLF+ +IAENI YG +++I +AA AN ++FI LP++++T VG G
Sbjct: 649 AIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKG 708
Query: 557 GQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHR 616
Q+SGGQKQR+AIARAL++ PKILLLD ATSALDN+SE +VQ L K + G T + V HR
Sbjct: 709 AQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVTHR 768
Query: 617 LSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQS 658
LS ++ AD I+ +G E+GTH+ELL + +YF LV QS
Sbjct: 769 LSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNAQS 810
Score = 201 bits (512), Expect = 3e-51
Identities = 102/178 (57%), Positives = 138/178 (77%), Gaps = 4/178 (2%)
Query: 1138 MIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYG-DNTKEIPMERVIAAAKQAQ 1196
M+D +D + +NV+ R +IG+VSQEPVLF +I +NIKYG D+ + MER AA++A
Sbjct: 1 MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMER---AAREAN 57
Query: 1197 LHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKT 1256
+DF+M P K+ T VG +G+Q+S G+KQRIAIARA+VR+PKIL+LDEATSALD+ES+
Sbjct: 58 AYDFIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSA 117
Query: 1257 VQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLV 1314
VQ AL+KA +GRT IV+AHRLSTI++AD+I + G++ EKG H ELMA++G YY LV
Sbjct: 118 VQAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLV 175
>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
sapiens]
Length = 738
Score = 334 bits (857), Expect = 3e-91
Identities = 197/508 (38%), Positives = 284/508 (55%), Gaps = 11/508 (2%)
Query: 158 IQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQM 217
I++ + R + ++R F I+R E+ +FD GEL R S D + ++ + +
Sbjct: 231 IRVYLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENL 290
Query: 218 ALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKA 277
+ ++ G + FF L ++SV P + I A G + K T + A+A
Sbjct: 291 SDGLRAGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQA 350
Query: 278 GVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVM-GFF--TGFVWCLIF 334
+A+E I ++RTV AFG E E+E+Y + + ++ GFF TG LI
Sbjct: 351 TQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLI- 409
Query: 335 LCYALAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIF 394
L+ Y L++ T G L + +++G S G A ++
Sbjct: 410 ---VLSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLW 466
Query: 395 ETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALV 454
E ++R+P + +G +EF NV F YP+RPEV I D ++ I G +TALV
Sbjct: 467 ELLEREPKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALV 526
Query: 455 GPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAE 514
GPSG+GKST L L+ R YDP G +++DGHDIR LN WLR +IG V QEP+LFS +IAE
Sbjct: 527 GPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAE 586
Query: 515 NIRYGRED---ATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIAR 571
NI YG +D T E+I + A+ ANA FI + PQ F+T+VGE G +SGGQKQR+AIAR
Sbjct: 587 NIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIAR 646
Query: 572 ALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEH 631
AL++NPKILLLD ATSALD E+E +VQE L ++ G T++ +AHRLST++ A+ + +
Sbjct: 647 ALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQ 706
Query: 632 GTAVERGTHEELLER-KGVYFTLVTLQS 658
G E G HEELL + G+Y L+ QS
Sbjct: 707 GKITEYGKHEELLSKPNGIYRKLMNKQS 734
Score = 305 bits (781), Expect = 2e-82
Identities = 198/584 (33%), Positives = 308/584 (52%), Gaps = 8/584 (1%)
Query: 742 RRILKFSAPEWPYMLVGSVGAAVNGTVTPLYA-FLFSQILGTFSIPDKEEQRSQINGVCL 800
R++L + PE L +VG +V + A F +I+ + + +CL
Sbjct: 158 RKLLGLAYPE-RRRLAAAVGFLTMSSVISMSAPFFLGKIIDVIYTNPTVDYSDNLTRLCL 216
Query: 801 LFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTR 860
A+ ++ Y SG+ + RLR F ++L Q++A+FD R G L R
Sbjct: 217 GLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRT--GELINR 274
Query: 861 LATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTR 920
L++D + + + + + + +V + + F S L+ +L P +++ R
Sbjct: 275 LSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGR 334
Query: 921 MLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANI 980
L + +L Q+ E + N+RTV GKE IE ++++ + A ++A
Sbjct: 335 YLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFA 394
Query: 981 Y-GFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRAFSYTP 1039
GF A I S Y+ GG L+ + + + + ++G S+
Sbjct: 395 RAGFFGATGLSGNLIVLSVLYK-GGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYS 453
Query: 1040 SYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGL 1099
K + R ++LL+R+P + +FQG ++F + F YP+RP+ +
Sbjct: 454 ELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDF 513
Query: 1100 SVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIV 1159
S+SI G A VG SG GKST + LL R YDP G + +DGHD +++N +LRS IG V
Sbjct: 514 SLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTV 573
Query: 1160 SQEPVLFACSIMDNIKYG-DNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQ 1218
SQEP+LF+CSI +NI YG D+ + E + A+ A F+ + P+ + T VG +G
Sbjct: 574 SQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVL 633
Query: 1219 LSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLS 1278
LS G+KQRIAIARA++++PKILLLDEATSALD E+E VQ ALD+ +GRT +VIAHRLS
Sbjct: 634 LSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLS 693
Query: 1279 TIQNADIIAVMAQGVVIEKGTHEELMAQ-KGAYYKLVTTGSPIS 1321
TI+NA+++AV+ QG + E G HEEL+++ G Y KL+ S IS
Sbjct: 694 TIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQSFIS 737
>gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo
sapiens]
Length = 718
Score = 322 bits (826), Expect = 1e-87
Identities = 193/511 (37%), Positives = 293/511 (57%), Gaps = 10/511 (1%)
Query: 152 VLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDCNSVGELNTRFSDDINKIND 211
+L GY+ + V R MR+ F ++R +I +FD N G+L +R + D+ +
Sbjct: 190 LLTFGYLVLLSHV--GERMAVDMRRALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKS 247
Query: 212 AIADQMALFIQRMTSTICGFLLGF-FRGWKLTLVIISVSP-LIGIGAATIGLSVSKFTDY 269
+ ++ ++ T + G L+ +LTL+++ +P L+G+G +G + K +
Sbjct: 248 SFKLVISQGLRSCTQ-VAGCLVSLSMLSTRLTLLLMVATPALMGVGTL-MGSGLRKLSRQ 305
Query: 270 ELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFV 329
+ A+A VADE + ++RTV AF E+RE ERY L + G + F G
Sbjct: 306 CQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLS 365
Query: 330 WCLIFLCYALA-FWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRA 388
+ F C L + G +LV + + T G L+ ++ ++ N S G +
Sbjct: 366 -NIAFNCMVLGTLFIGGSLVAGQ-QLTGGDLMSFLVASQTVQRSMANLSVLFGQVVRGLS 423
Query: 389 AATSIFETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPG 448
A +FE + P I ++++G + F NV F YP RP ++L D + + PG
Sbjct: 424 AGARVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPG 483
Query: 449 EMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQI-GIVEQEPVL 507
++ ALVG SG GK+T L++RFYDP G+V +DG D+R+L+ WLR Q+ G + QEPVL
Sbjct: 484 KIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVL 543
Query: 508 FSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRV 567
F TTI ENIR+G+ +A+ E++ AA+EANA+ FI P+ ++T+VGE G +SGGQKQR+
Sbjct: 544 FGTTIMENIRFGKLEASDEEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRL 603
Query: 568 AIARALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTII 627
AIARALI+ P +L+LD ATSALD ESE +VQE L + G T++ +AHRLSTVR A I+
Sbjct: 604 AIARALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIV 663
Query: 628 GFEHGTAVERGTHEELLERKGVYFTLVTLQS 658
G E GTHEELL++ G+Y L+ Q+
Sbjct: 664 VMADGRVWEAGTHEELLKKGGLYAELIRRQA 694
Score = 287 bits (735), Expect = 4e-77
Identities = 184/499 (36%), Positives = 272/499 (54%), Gaps = 19/499 (3%)
Query: 824 GELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSF 883
GE + +R+ F ++L QDI +FD N G L +RL TD + + + I + S
Sbjct: 203 GERMAVDMRRALFSSLLRQDITFFD--ANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSC 260
Query: 884 TNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQ---IT 940
T V ++ S +L+L+++ P L G T M +G +Q E + + +
Sbjct: 261 TQVAGCLVSLSMLSTRLTLLLMVATPALMGVG---TLMGSGLRKLSRQCQEQIARAMGVA 317
Query: 941 NEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANIYGFCFAFAQCIMFIANSA-- 998
+EAL N+RTV E+R E ELE +A G A Q + IA +
Sbjct: 318 DEALGNVRTVRAFAMEQREEERYGAELE----ACRCRAEELGRGIALFQGLSNIAFNCMV 373
Query: 999 --SYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLD 1056
+ GG L++ + L + + A ++ + + AR F+ +
Sbjct: 374 LGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGARVFEYMA 433
Query: 1057 RQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSG 1116
P I + + +G + F + F+YP RP +VL ++++ PG+ +A VG SG
Sbjct: 434 LNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSG 493
Query: 1117 CGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNI-GIVSQEPVLFACSIMDNIK 1175
GK+T LLERFYDP G VM+DG D + ++ +LR + G +SQEPVLF +IM+NI+
Sbjct: 494 GGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENIR 553
Query: 1176 YGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVR 1235
+G E E V AA++A H+F+ S PE Y T VG +G+ LS G+KQR+AIARA+++
Sbjct: 554 FGK--LEASDEEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIK 611
Query: 1236 DPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVI 1295
P +L+LDEATSALD ESE+ VQ ALD+A GRT +VIAHRLST++ A I VMA G V
Sbjct: 612 QPTVLILDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVW 671
Query: 1296 EKGTHEELMAQKGAYYKLV 1314
E GTHEEL+ + G Y +L+
Sbjct: 672 EAGTHEELLKKGGLYAELI 690
>gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 318 bits (814), Expect = 3e-86
Identities = 193/587 (32%), Positives = 316/587 (53%), Gaps = 15/587 (2%)
Query: 731 PVQEEVEPAPVRRILKFSAPEWPYMLVGS---VGAAVNGTVTPLYAFLFSQILGTFSIPD 787
P E+ A ++++L ++ P+ +++ S + AA+ T P Y I G
Sbjct: 164 PPPEQASGATLQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYTG--RAIDGIVIQKS 221
Query: 788 KEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWF 847
++ + + VCLL + S F ++G F L RLR FR+++ Q+ ++F
Sbjct: 222 MDQFSTAVVIVCLLAIG----SSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFF 277
Query: 848 DDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCF 907
D+ N G L +RL +D + V I + + + VT ++ FS SW+LSLV
Sbjct: 278 DE--NRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMG 335
Query: 908 FPFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETEL 967
FP + + + + + AL E +S ++TV E E +L
Sbjct: 336 FPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKL 395
Query: 968 EKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLS 1027
++ +K ++A Y + + + + + YGG+L+ + + + I +
Sbjct: 396 QQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVL 455
Query: 1028 ATALGRAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTY 1087
+ S + +A + F+ +DRQP ++ + D+ +G++DF + FTY
Sbjct: 456 GDCMESVGSVYSGLMQGVGAAEKVFEFIDRQP--TMVHDGSLAPDHLEGRVDFENVTFTY 513
Query: 1088 PSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKV 1147
+RP +QVL +S S+SPG+ A VG SG GKS+ + +LE FY + G+V++DG
Sbjct: 514 RTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAY 573
Query: 1148 NVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEK 1207
+ ++L I +VSQEPVLFA SI DNI YG T +P E V+ AA++A H F+M L +
Sbjct: 574 DHKYLHRVISLVSQEPVLFARSITDNISYGLPT--VPFEMVVEAAQKANAHGFIMELQDG 631
Query: 1208 YETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREG 1267
Y T G +G+QLS G+KQR+A+ARA+VR+P +L+LDEATSALD ESE +Q A+ +
Sbjct: 632 YSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQK 691
Query: 1268 RTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLV 1314
T ++IAHRLST+++A +I V+ +G V+++GTH++L+AQ G Y KLV
Sbjct: 692 HTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLV 738
Score = 308 bits (788), Expect = 3e-83
Identities = 180/546 (32%), Positives = 291/546 (53%), Gaps = 27/546 (4%)
Query: 141 FASYYAGIAVAVLI---------TGYIQICFWVIAA---------------ARQIQKMRK 176
F YY G A+ ++ T + +C I + AR ++R
Sbjct: 204 FLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRN 263
Query: 177 FYFRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFF 236
FR ++ E +FD N G+L +R + D ++D ++ + +F++ + F
Sbjct: 264 CLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFS 323
Query: 237 RGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGG 296
W+L+LV P+I + + G + + A A+A A+E IS+M+TV +F
Sbjct: 324 LSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFAN 383
Query: 297 EKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTP 356
E+ E E Y + L + ++ ++ + + +YG LV+ G+ T
Sbjct: 384 EEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVIS-GQMTS 442
Query: 357 GTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRI 416
G L+ + V + + G AA +FE IDR+P + + + D +
Sbjct: 443 GNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTM--VHDGSLAPDHL 500
Query: 417 KGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCE 476
+G ++F NVTF Y +RP ++L +++ + PG++TALVGPSG+GKS+ + +++ FY
Sbjct: 501 EGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEG 560
Query: 477 GMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEAN 536
G V +DG I + + ++L I +V QEPVLF+ +I +NI YG E +V+AA++AN
Sbjct: 561 GRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKAN 620
Query: 537 AYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAM 596
A+ FIM+L + T GE G Q+SGGQKQRVA+ARAL+RNP +L+LD ATSALD ESE +
Sbjct: 621 AHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYL 680
Query: 597 VQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTL 656
+Q+ + HT++ +AHRLSTV A I+ + G V++GTH++LL + G+Y LV
Sbjct: 681 IQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQR 740
Query: 657 QSQGNQ 662
Q G Q
Sbjct: 741 QMLGLQ 746
>gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 318 bits (814), Expect = 3e-86
Identities = 193/587 (32%), Positives = 316/587 (53%), Gaps = 15/587 (2%)
Query: 731 PVQEEVEPAPVRRILKFSAPEWPYMLVGS---VGAAVNGTVTPLYAFLFSQILGTFSIPD 787
P E+ A ++++L ++ P+ +++ S + AA+ T P Y I G
Sbjct: 164 PPPEQASGATLQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYTG--RAIDGIVIQKS 221
Query: 788 KEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWF 847
++ + + VCLL + S F ++G F L RLR FR+++ Q+ ++F
Sbjct: 222 MDQFSTAVVIVCLLAIG----SSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFF 277
Query: 848 DDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCF 907
D+ N G L +RL +D + V I + + + VT ++ FS SW+LSLV
Sbjct: 278 DE--NRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMG 335
Query: 908 FPFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETEL 967
FP + + + + + AL E +S ++TV E E +L
Sbjct: 336 FPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKL 395
Query: 968 EKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLS 1027
++ +K ++A Y + + + + + YGG+L+ + + + I +
Sbjct: 396 QQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVL 455
Query: 1028 ATALGRAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTY 1087
+ S + +A + F+ +DRQP ++ + D+ +G++DF + FTY
Sbjct: 456 GDCMESVGSVYSGLMQGVGAAEKVFEFIDRQP--TMVHDGSLAPDHLEGRVDFENVTFTY 513
Query: 1088 PSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKV 1147
+RP +QVL +S S+SPG+ A VG SG GKS+ + +LE FY + G+V++DG
Sbjct: 514 RTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAY 573
Query: 1148 NVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEK 1207
+ ++L I +VSQEPVLFA SI DNI YG T +P E V+ AA++A H F+M L +
Sbjct: 574 DHKYLHRVISLVSQEPVLFARSITDNISYGLPT--VPFEMVVEAAQKANAHGFIMELQDG 631
Query: 1208 YETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREG 1267
Y T G +G+QLS G+KQR+A+ARA+VR+P +L+LDEATSALD ESE +Q A+ +
Sbjct: 632 YSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQK 691
Query: 1268 RTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLV 1314
T ++IAHRLST+++A +I V+ +G V+++GTH++L+AQ G Y KLV
Sbjct: 692 HTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLV 738
Score = 308 bits (788), Expect = 3e-83
Identities = 180/546 (32%), Positives = 291/546 (53%), Gaps = 27/546 (4%)
Query: 141 FASYYAGIAVAVLI---------TGYIQICFWVIAA---------------ARQIQKMRK 176
F YY G A+ ++ T + +C I + AR ++R
Sbjct: 204 FLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRN 263
Query: 177 FYFRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFF 236
FR ++ E +FD N G+L +R + D ++D ++ + +F++ + F
Sbjct: 264 CLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFS 323
Query: 237 RGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGG 296
W+L+LV P+I + + G + + A A+A A+E IS+M+TV +F
Sbjct: 324 LSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFAN 383
Query: 297 EKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTP 356
E+ E E Y + L + ++ ++ + + +YG LV+ G+ T
Sbjct: 384 EEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVIS-GQMTS 442
Query: 357 GTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRI 416
G L+ + V + + G AA +FE IDR+P + + + D +
Sbjct: 443 GNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTM--VHDGSLAPDHL 500
Query: 417 KGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCE 476
+G ++F NVTF Y +RP ++L +++ + PG++TALVGPSG+GKS+ + +++ FY
Sbjct: 501 EGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEG 560
Query: 477 GMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEAN 536
G V +DG I + + ++L I +V QEPVLF+ +I +NI YG E +V+AA++AN
Sbjct: 561 GRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKAN 620
Query: 537 AYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAM 596
A+ FIM+L + T GE G Q+SGGQKQRVA+ARAL+RNP +L+LD ATSALD ESE +
Sbjct: 621 AHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYL 680
Query: 597 VQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTL 656
+Q+ + HT++ +AHRLSTV A I+ + G V++GTH++LL + G+Y LV
Sbjct: 681 IQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQR 740
Query: 657 QSQGNQ 662
Q G Q
Sbjct: 741 QMLGLQ 746
>gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 2 [Homo sapiens]
Length = 723
Score = 302 bits (773), Expect = 2e-81
Identities = 192/587 (32%), Positives = 308/587 (52%), Gaps = 58/587 (9%)
Query: 731 PVQEEVEPAPVRRILKFSAPEWPYMLVGS---VGAAVNGTVTPLYAFLFSQILGTFSIPD 787
P E+ A ++++L ++ P+ +++ S + AA+ T P Y I G
Sbjct: 164 PPPEQASGATLQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYTG--RAIDGIVIQKS 221
Query: 788 KEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWF 847
++ + + VCLL + S F ++G F L RLR FR+++ Q+ ++F
Sbjct: 222 MDQFSTAVVIVCLLAIG----SSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFF 277
Query: 848 DDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCF 907
D+ N G L +RL +D + V I + + + VT ++ FS SW+LSLV
Sbjct: 278 DE--NRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMG 335
Query: 908 FPFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETEL 967
FP + + + + + AL E +S ++TV E E +L
Sbjct: 336 FPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKL 395
Query: 968 EKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLS 1027
++ +K ++A A+Y Y + + G +S + + + A
Sbjct: 396 QQVYKLNRKEA-------------------AAYMYYVWGSGSVGSVYSGLMQGVGA---- 432
Query: 1028 ATALGRAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTY 1087
A + F+ +DRQP ++ + D+ +G++DF + FTY
Sbjct: 433 --------------------AEKVFEFIDRQP--TMVHDGSLAPDHLEGRVDFENVTFTY 470
Query: 1088 PSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKV 1147
+RP +QVL +S S+SPG+ A VG SG GKS+ + +LE FY + G+V++DG
Sbjct: 471 RTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAY 530
Query: 1148 NVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEK 1207
+ ++L I +VSQEPVLFA SI DNI YG T +P E V+ AA++A H F+M L +
Sbjct: 531 DHKYLHRVISLVSQEPVLFARSITDNISYGLPT--VPFEMVVEAAQKANAHGFIMELQDG 588
Query: 1208 YETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREG 1267
Y T G +G+QLS G+KQR+A+ARA+VR+P +L+LDEATSALD ESE +Q A+ +
Sbjct: 589 YSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQK 648
Query: 1268 RTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLV 1314
T ++IAHRLST+++A +I V+ +G V+++GTH++L+AQ G Y KLV
Sbjct: 649 HTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLV 695
Score = 285 bits (730), Expect = 2e-76
Identities = 176/546 (32%), Positives = 279/546 (51%), Gaps = 70/546 (12%)
Query: 141 FASYYAGIAVAVLI---------TGYIQICFWVIAA---------------ARQIQKMRK 176
F YY G A+ ++ T + +C I + AR ++R
Sbjct: 204 FLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRN 263
Query: 177 FYFRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFF 236
FR ++ E +FD N G+L +R + D ++D ++ + +F++ + F
Sbjct: 264 CLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFS 323
Query: 237 RGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGG 296
W+L+LV P+I + + G + + A A+A A+E IS+M+TV +F
Sbjct: 324 LSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFAN 383
Query: 297 EKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTP 356
E+ E E Y + L + ++ ++ VW GS
Sbjct: 384 EEEEAEVYLRKLQQVYKLNRKEAAAYMYY---VW-------------GS----------- 416
Query: 357 GTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRI 416
G+ G AA +FE IDR+P + + + D +
Sbjct: 417 -----------------GSVGSVYSGLMQGVGAAEKVFEFIDRQPTM--VHDGSLAPDHL 457
Query: 417 KGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCE 476
+G ++F NVTF Y +RP ++L +++ + PG++TALVGPSG+GKS+ + +++ FY
Sbjct: 458 EGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEG 517
Query: 477 GMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEAN 536
G V +DG I + + ++L I +V QEPVLF+ +I +NI YG E +V+AA++AN
Sbjct: 518 GRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKAN 577
Query: 537 AYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAM 596
A+ FIM+L + T GE G Q+SGGQKQRVA+ARAL+RNP +L+LD ATSALD ESE +
Sbjct: 578 AHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYL 637
Query: 597 VQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTL 656
+Q+ + HT++ +AHRLSTV A I+ + G V++GTH++LL + G+Y LV
Sbjct: 638 IQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQR 697
Query: 657 QSQGNQ 662
Q G Q
Sbjct: 698 QMLGLQ 703
>gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Homo
sapiens]
Length = 808
Score = 254 bits (649), Expect = 4e-67
Identities = 154/479 (32%), Positives = 256/479 (53%), Gaps = 6/479 (1%)
Query: 179 FRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRG 238
F ++R E +F N G + +R ++D + ++D++++ ++LF+ + +C + +
Sbjct: 325 FGAVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGS 384
Query: 239 WKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEK 298
LT+V + PL+ + +G ++ AK+ VA E +S+M TV +F E+
Sbjct: 385 VSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEE 444
Query: 299 REVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTPGT 358
E +++ + L + ++ + + L + G LV G + G
Sbjct: 445 GEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTS-GAVSSGN 503
Query: 359 LVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRIKG 418
LV L + + ++ IFE +DR P C ++G
Sbjct: 504 LVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTP--RCPPSGLLTPLHLEG 561
Query: 419 EIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGM 478
++F +V+F YP+RP+V +L L ++PGE+TALVGP+G+GKST L+Q Y P G
Sbjct: 562 LVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQ 621
Query: 479 VTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYG-REDATMEDIVQAAKEANA 537
+ +DG + ++L Q+ V QEP +F ++ ENI YG + TME+I AA ++ A
Sbjct: 622 LLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGA 681
Query: 538 YNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMV 597
++FI LPQ +DT V E G Q+SGGQ+Q VA+ARALIR P +L+LD ATSALD S+ V
Sbjct: 682 HSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQV 741
Query: 598 QEVL--SKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLV 654
+++L S ++ +++ + LS V AD I+ E G E GTH++L+E+KG Y+ +V
Sbjct: 742 EQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAMV 800
Score = 219 bits (558), Expect = 1e-56
Identities = 147/485 (30%), Positives = 243/485 (50%), Gaps = 15/485 (3%)
Query: 836 FRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFS 895
F A+L Q+ +F +N G + +R+ D S + + + + + + I
Sbjct: 325 FGAVLRQETEFFQ--QNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLW 382
Query: 896 FSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGK 955
S L++V L P L L + + +++L Q+ EALS + TV
Sbjct: 383 GSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFAN 442
Query: 956 ERRFIEALETELEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRY-GGYLISNEGLHF 1014
E + +L++ KT QK + ++ I + Y GG L+++ +
Sbjct: 443 EEGEAQKFREKLQE-IKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSS 501
Query: 1015 SYVFRVISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLDRQP---PISVYNTAGEKW 1071
+ + + A+ S P KA S+ + F+ LDR P P +
Sbjct: 502 GNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLLTPL---- 557
Query: 1072 DNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYD 1131
+ +G + F D F YP+RPD VL GL+ ++ PG+ A VG +G GKST LL+ Y
Sbjct: 558 -HLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQ 616
Query: 1132 PDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAA 1191
P G++++DG + ++L + V QEP +F S+ +NI YG T++ ME + AA
Sbjct: 617 PTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYG-LTQKPTMEEITAA 675
Query: 1192 AKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDT 1251
A ++ H F+ LP+ Y+T V GSQLS G++Q +A+ARA++R P +L+LD+ATSALD
Sbjct: 676 AVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDA 735
Query: 1252 ESEKTVQVALDKA--REGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGA 1309
S+ V+ L ++ R R+ ++I LS ++ AD I + G + E GTH++LM +KG
Sbjct: 736 NSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGC 795
Query: 1310 YYKLV 1314
Y+ +V
Sbjct: 796 YWAMV 800
>gi|73747915 transporter 2, ATP-binding cassette, sub-family B isoform
1 [Homo sapiens]
Length = 703
Score = 226 bits (577), Expect = 9e-59
Identities = 174/566 (30%), Positives = 267/566 (47%), Gaps = 43/566 (7%)
Query: 743 RILKFSAPEWPYMLVGS---VGAAVNGTVTPLYAFLFSQILGTFSIPDKEEQRSQINGVC 799
R+LK S P+ P ++ V A + T+ P Y+ ILG D S I +C
Sbjct: 140 RLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYSGRVIDILGGDF--DPHAFASAIFFMC 197
Query: 800 LLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTT 859
L S + +G F + + R+R+ F ++L QD+ +F + + G L +
Sbjct: 198 LFSFG----SSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFFQETKT--GELNS 251
Query: 860 RLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQT 919
RL++D + + +++ S V S S +L+L+ L PF +
Sbjct: 252 RLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTLLSLLHMPFTIAAEKVYN 311
Query: 920 RMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKER----RFIEALE--------TEL 967
+ A+ GQ+ EA+ ++TV G E R+ EALE +L
Sbjct: 312 TRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDL 371
Query: 968 EKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLS 1027
E+ +++ G C G L L F + + V
Sbjct: 372 ERALYLLVRRVLHLGVQMLMLSC------GLQQMQDGELTQGSLLSFMIYQESVGSYV-- 423
Query: 1028 ATALGRAFSYTPSYAKAKISAA-RFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFT 1086
+ Y + + AA + F +DRQP + T QG + F D F
Sbjct: 424 -----QTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAP--TTLQGVVKFQDVSFA 476
Query: 1087 YPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKK 1146
YP+RPD VL GL+ ++ PG+ A VG +G GKST LL+ Y P G+V++D +
Sbjct: 477 YPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQ 536
Query: 1147 VNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPE 1206
+L S + V QEPVLF+ S+ +NI YG + E ++V+AAA+ A DF+ +
Sbjct: 537 YEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE--DDKVMAAAQAAHADDFIQEMEH 594
Query: 1207 KYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKARE 1266
T+VG +GSQL+ G+KQR+AIARA+VRDP++L+LDEATSALD + E+ +Q +R
Sbjct: 595 GIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDW--NSRG 652
Query: 1267 GRTCIVIAHRLSTIQNADIIAVMAQG 1292
RT +VIAHRL +Q A I V+ +G
Sbjct: 653 DRTVLVIAHRLQAVQRAHQILVLQEG 678
Score = 219 bits (558), Expect = 1e-56
Identities = 151/488 (30%), Positives = 254/488 (52%), Gaps = 20/488 (4%)
Query: 173 KMRKFYFRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTI--CG 230
++R+ F ++R ++G+F GELN+R S D +++ + + ++ + + G
Sbjct: 224 RIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYG 283
Query: 231 FLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRT 290
F+L +LTL+ + P + A A+AG V E + ++T
Sbjct: 284 FMLSISP--RLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQT 341
Query: 291 VAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTLVLD 350
V +FG E+ EV RY++ L ++ R+ + + V ++ L + +
Sbjct: 342 VRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYL-LVRRVLHLGVQMLMLSCGLQQMQ 400
Query: 351 EGEYTPGTLVQIFLSVIVGALNLGNASPCLEAF----ATGRAAATSIFETIDRKPIIDCM 406
+GE T G+L LS ++ ++G+ L + AA +F +DR+P +
Sbjct: 401 DGELTQGSL----LSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLP-- 454
Query: 407 SEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQ 466
S ++G ++F +V+F YP+RP+ +L L ++PGE+TALVGP+G+GKST
Sbjct: 455 SPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAA 514
Query: 467 LIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATME 526
L+Q Y P G V +D I +L Q+ V QEPVLFS ++ NI YG + +
Sbjct: 515 LLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDD 574
Query: 527 DIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMAT 586
++ AA+ A+A +FI ++ T VGE G Q++ GQKQR+AIARAL+R+P++L+LD AT
Sbjct: 575 KVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEAT 634
Query: 587 SALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLER 646
SALD + E +Q+ S+ T++ +AHRL V+ A I+ + G + +L E
Sbjct: 635 SALDVQCEQALQDWNSR--GDRTVLVIAHRLQAVQRAHQILVLQEGKLQKLA---QLQEG 689
Query: 647 KGVYFTLV 654
+ +Y LV
Sbjct: 690 QDLYSRLV 697
>gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo
sapiens]
Length = 842
Score = 226 bits (577), Expect = 9e-59
Identities = 174/549 (31%), Positives = 267/549 (48%), Gaps = 73/549 (13%)
Query: 155 TGYI---QICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDCNSVGELNTRFSDDINKIND 211
TG++ + W+ +++ F + + + W GE+ R +D +
Sbjct: 323 TGFVSNLRTFLWIRVQQFTSRRVELLIFSHLHELSLRWHLGRRTGEV-LRIAD---RGTS 378
Query: 212 AIADQMALFIQRMTSTICGFLLG------FFRGWKLTLVIISVSPLIGIGAATIGLSVSK 265
++ ++ + + T+ ++G FF W +V + +S + T+ + V++
Sbjct: 379 SVTGLLSYLVFNVIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYL-----TLTIVVTE 433
Query: 266 F-TDYELKAYAKAGVVADEVISSM---RTVAAFGGEKREVERYEKNLVFAQ--RWGIRKG 319
+ T + + + S+ TV + E EVERY + ++ Q W
Sbjct: 434 WRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSAS 493
Query: 320 IVM-----------GFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTP-GT-LVQIFLSV 366
+V+ G G + C F+ + L G+Y GT ++Q+++
Sbjct: 494 LVLLNQTQNLVIGLGLLAGSLLCAYFV---------TEQKLQVGDYVLFGTYIIQLYMP- 543
Query: 367 IVGALNLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRI--------KG 418
L F T + F ID + + D + E+ D KG
Sbjct: 544 -------------LNWFGTYYRMIQTNF--IDMENMFDLLKEETEVKDLPGAGPLRFQKG 588
Query: 419 EIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGM 478
IEF NV F Y E L D++ + PG+ ALVGPSGAGKST L+L+ RFYD G
Sbjct: 589 RIEFENVHFSYADGRET--LQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGC 646
Query: 479 VTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAY 538
+ +DG DI + LR IG+V Q+ VLF+ TIA+NIRYGR A +++ AA+ A +
Sbjct: 647 IRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIH 706
Query: 539 NFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQ 598
+ IM P+ + T VGE G ++SGG+KQRVAIAR +++ P I+LLD ATSALD +E +Q
Sbjct: 707 DAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQ 766
Query: 599 EVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQS 658
L+K+ T I VAHRLSTV AD I+ + G VERG HE LL R GVY + LQ
Sbjct: 767 ASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQ- 825
Query: 659 QGNQALNEE 667
QG + +E+
Sbjct: 826 QGQEETSED 834
Score = 218 bits (556), Expect = 2e-56
Identities = 125/266 (46%), Positives = 168/266 (63%), Gaps = 7/266 (2%)
Query: 1046 ISAARFFQLLDRQPPISVYNTAGEKWDNFQ-GKIDFVDCKFTYPSRPDSQVLNGLSVSIS 1104
I F LL + + AG FQ G+I+F + F+Y + L +S ++
Sbjct: 559 IDMENMFDLLKEETEVKDLPGAGPL--RFQKGRIEFENVHFSYAD--GRETLQDVSFTVM 614
Query: 1105 PGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPV 1164
PGQTLA VG SG GKST ++LL RFYD G + IDG D +V LRS+IG+V Q+ V
Sbjct: 615 PGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRSHIGVVPQDTV 674
Query: 1165 LFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEK 1224
LF +I DNI+YG T + V AAA+ A +HD +M+ PE Y T VG +G +LS GEK
Sbjct: 675 LFNDTIADNIRYGRVTAG--NDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLKLSGGEK 732
Query: 1225 QRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNAD 1284
QR+AIAR I++ P I+LLDEATSALDT +E+ +Q +L K RT IV+AHRLST+ NAD
Sbjct: 733 QRVAIARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRLSTVVNAD 792
Query: 1285 IIAVMAQGVVIEKGTHEELMAQKGAY 1310
I V+ G ++E+G HE L+++ G Y
Sbjct: 793 QILVIKDGCIVERGRHEALLSRGGVY 818
>gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1
[Homo sapiens]
Length = 1531
Score = 224 bits (571), Expect = 4e-58
Identities = 242/963 (25%), Positives = 420/963 (43%), Gaps = 110/963 (11%)
Query: 395 ETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALV 454
++I+R+P+ D + I N TF + +R + LN + I G + A+V
Sbjct: 628 DSIERRPVKDGGGTNS---------ITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVV 677
Query: 455 GPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAE 514
G G GKS+ L + D EG V + G + V Q+ + + ++ E
Sbjct: 678 GQVGCGKSSLLSALLAEMDKVEGHVAIKG-------------SVAYVPQQAWIQNDSLRE 724
Query: 515 NIRYG--REDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARA 572
NI +G E+ ++QA LP T +GE G +SGGQKQRV++ARA
Sbjct: 725 NILFGCQLEEPYYRSVIQACALLPDLEI---LPSGDRTEIGEKGVNLSGGQKQRVSLARA 781
Query: 573 LIRNPKILLLDMATSALD-NESEAMVQEVLSK--IQHGHTIISVAHRLSTVRAADTIIGF 629
+ N I L D SA+D + + + + V+ + T I V H +S + D II
Sbjct: 782 VYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVM 841
Query: 630 EHGTAVERGTHEELLERKGVY--FTLVTLQSQGNQALNEEDIKDATEDDMLARTFSRGSY 687
G E G+++ELL R G + F ++ Q E + + A+ G
Sbjct: 842 SGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGML 901
Query: 688 -QDSLRASIRQRSKSQLSYLVHEPPLAVVDHKSTYE----EDRKDKDIPVQEEVEPAPVR 742
DS ++++ S SY H ST E E +K++ + E + A
Sbjct: 902 VTDSAGKQLQRQLSSSSSYSGDISR----HHNSTAELQKAEAKKEETWKLME-ADKAQTG 956
Query: 743 RILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQILGTFS-----------IPDKEEQ 791
++ K S W YM ++G ++ ++ F+ + + S I + ++
Sbjct: 957 QV-KLSV-YWDYMK--AIGLFIS--FLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQE 1010
Query: 792 RSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLR 851
+++ ++ A+G F A + G L ++ L ++L +++F+ R
Sbjct: 1011 HTKVR--LSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFE--R 1066
Query: 852 NSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFL 911
G L R + + V I M + S NV A I+ + +++I P L
Sbjct: 1067 TPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIII----PPL 1122
Query: 912 ALSGATQTRMLTGFASRDKQALEMVGQIT-----NEALSNIRTVAGIGKERRFIEALETE 966
L R +SR + LE V + NE L + + ++ RFI + +
Sbjct: 1123 GLIYFFVQRFYVA-SSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLK 1181
Query: 967 LEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVL 1026
+++ K + +C+ N + F+ +F VIS L
Sbjct: 1182 VDENQKAYYPSIVANRWLAVRLECV----------------GNCIVLFAALFAVISRHSL 1225
Query: 1027 SATALGRAFSYT-------------PSYAKAKISAA---RFFQLLDRQPPISVYNTAGEK 1070
SA +G + SY+ S + I A + + +++ P + TA
Sbjct: 1226 SAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPS 1285
Query: 1071 WDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFY 1130
G+++F + Y D VL ++V+I+ G+ + VG +G GKS+ L R
Sbjct: 1286 SWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRIN 1344
Query: 1131 DPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIA 1190
+ +G+++IDG + K+ + LR I I+ Q+PVLF+ S+ N+ D + E V
Sbjct: 1345 ESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNL---DPFSQYSDEEVWT 1401
Query: 1191 AAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALD 1250
+ + A L DFV +LP+K + G LS G++Q + +ARA++R KIL+LDEAT+A+D
Sbjct: 1402 SLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVD 1461
Query: 1251 TESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAY 1310
E++ +Q + E T + IAHRL+TI + + V+ +G + E G +L+ Q+G +
Sbjct: 1462 LETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLF 1521
Query: 1311 YKL 1313
Y +
Sbjct: 1522 YSM 1524
Score = 107 bits (267), Expect = 8e-23
Identities = 75/235 (31%), Positives = 121/235 (51%), Gaps = 20/235 (8%)
Query: 1085 FTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDS 1144
FT+ +R D LNG++ SI G +A VG GCGKS+ + L D +G V I G
Sbjct: 651 FTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG--- 706
Query: 1145 KKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSL 1204
++ V Q+ + S+ +NI +G +E VI A A L D + L
Sbjct: 707 ----------SVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQAC--ALLPDLEI-L 753
Query: 1205 PEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTV---QVAL 1261
P T +G +G LS G+KQR+++ARA+ + I L D+ SA+D K + +
Sbjct: 754 PSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGP 813
Query: 1262 DKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVTT 1316
+ +T I++ H +S + D+I VM+ G + E G+++EL+A+ GA+ + + T
Sbjct: 814 KGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRT 868
>gi|190343023 ATP-binding cassette, sub-family C, member 6 isoform 1
[Homo sapiens]
Length = 1503
Score = 221 bits (564), Expect = 3e-57
Identities = 283/1207 (23%), Positives = 510/1207 (42%), Gaps = 172/1207 (14%)
Query: 179 FRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRG 238
+R+++ + G ++VG++ S D+ ++ +++ L++ + +C L
Sbjct: 390 YRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFVYL----- 444
Query: 239 WKLTLVIISVSPLIGIGAATIGLSVSKFTDY----ELKAYAKAGVVADEVISSMRTVAAF 294
W+L + + + + +SK ++ +++ + ++ + +T+
Sbjct: 445 WQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFH 504
Query: 295 GGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFV-WCLIFLCYALAFWYGSTLVLDEGE 353
G E ++R + Q G + + F V + + AL + TLV +
Sbjct: 505 GWEGAFLDRVLG--IRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAM 562
Query: 354 YTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSE----- 408
V + + LN+ N + F+ + + DR C+ E
Sbjct: 563 NAEKAFVTLTV------LNILNKAQAFLPFSIHSLVQARV--SFDRLVTFLCLEEVDPGV 614
Query: 409 -DGYKLDRIKGE--IEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTAL 465
D G+ I H+ TF + S+ L+ +N+ + G + A+VGP GAGKS+ L
Sbjct: 615 VDSSSSGSAAGKDCITIHSATFAW-SQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLL 673
Query: 466 QLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGRE--DA 523
+ EG V+++G + V QE + +T++ EN+ +G+E
Sbjct: 674 SALLGELSKVEGFVSIEG-------------AVAYVPQEAWVQNTSVVENVCFGQELDPP 720
Query: 524 TMEDIVQA-AKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLL 582
+E +++A A + + +F P+ T +GE G +SGGQKQR+++ARA+ R + LL
Sbjct: 721 WLERVLEACALQPDVDSF----PEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLL 776
Query: 583 DMATSALD-NESEAMVQEVLSK--IQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGT 639
D +ALD + + + +V+ + G T I V H L + AD II +G E G+
Sbjct: 777 DDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGS 836
Query: 640 HEELLERKGVYFTLVTLQSQ-GNQALNEEDIKDATEDDMLARTFSRGSYQDSLRASIRQR 698
++ELL+RKG L+ Q G++ E + +T+D RG+ R+R
Sbjct: 837 YQELLQRKGALVCLLDQARQPGDRGEGETEPGTSTKDP-------RGTSAGRRPELRRER 889
Query: 699 SKSQLSYLVHEPPLAVVDHKSTYEEDRKDKDIPVQEEVEPAPVRRILKFSAPEWPY---- 754
S KS E+DR + + ++ WP
Sbjct: 890 SI-----------------KSVPEKDRTTSEAQTEVPLDDP--------DRAGWPAGKDS 924
Query: 755 MLVGSVGAAVN-------GTVTPLYA-FLF-SQILGTF-------------SIPDKEEQR 792
+ G V A V+ GT LYA FLF Q + +F ++ ++ Q
Sbjct: 925 IQYGRVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLWADDPAVGGQQTQA 984
Query: 793 SQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRN 852
+ G+ F +GC+ F A G ++ L + ++ I++F+ R
Sbjct: 985 ALRGGI---FGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFE--RT 1039
Query: 853 SPGALTTRLATDASQVQGAAGSQI-GMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFP-F 910
G L R + + V ++ +++ +F + V++++A + L + P F
Sbjct: 1040 PIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVA----TPLATVAILPLF 1095
Query: 911 LALSGATQTRMLTGFASR--DKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELE 968
L +G +++ R + + V E V + F+ ++
Sbjct: 1096 LLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVD 1155
Query: 969 KPFKTAIQK--------ANIY----GFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSY 1016
+ + + + AN+ G FA A C + S G+ +S
Sbjct: 1156 ESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAA----LQ 1211
Query: 1017 VFRVISAVVLSATALGRA---------FSYTPSYAKAKISAARFFQLLDRQPPISVYNTA 1067
V + + VV + T L + +++TP A ++ QPP
Sbjct: 1212 VTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCA------AQPP------- 1258
Query: 1068 GEKWDNFQGKIDFVDCKFTYPSRPDSQV-LNGLSVSISPGQTLAFVGSSGCGKSTSIQLL 1126
W G+I+F D Y RP+ + + G+S I G+ + VG +G GKS+ L
Sbjct: 1259 ---WPQ-GGQIEFRDFGLRY--RPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGL 1312
Query: 1127 ERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPME 1186
R + +G + IDG V + LRS I I+ Q+P+LF S+ N+ D +E E
Sbjct: 1313 LRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNL---DLLQEHSDE 1369
Query: 1187 RVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEAT 1246
+ AA + QL V SLP + + +G LS G+KQ + +ARA++R +IL+LDEAT
Sbjct: 1370 AIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEAT 1429
Query: 1247 SALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQ 1306
+A+D +E +Q L T ++IAHRL ++ + + VM +G V E G+ +L+AQ
Sbjct: 1430 AAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQ 1489
Query: 1307 KGAYYKL 1313
KG +Y+L
Sbjct: 1490 KGLFYRL 1496
>gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1312
Score = 219 bits (557), Expect = 2e-56
Identities = 282/1207 (23%), Positives = 509/1207 (42%), Gaps = 172/1207 (14%)
Query: 179 FRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRG 238
+R+++ + G ++VG++ S D+ ++ +++ L++ + +C L
Sbjct: 199 YRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFVYL----- 253
Query: 239 WKLTLVIISVSPLIGIGAATIGLSVSKFTDY----ELKAYAKAGVVADEVISSMRTVAAF 294
W+L + + + + +SK ++ +++ + ++ + +T+
Sbjct: 254 WQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFH 313
Query: 295 GGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFV-WCLIFLCYALAFWYGSTLVLDEGE 353
G E ++R + Q G + + F V + + AL + TLV +
Sbjct: 314 GWEGAFLDRVLG--IRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAM 371
Query: 354 YTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSE----- 408
V + + LN+ N + F+ + + DR C+ E
Sbjct: 372 NAEKAFVTLTV------LNILNKAQAFLPFSIHSLVQARV--SFDRLVTFLCLEEVDPGA 423
Query: 409 -DGYKLDRIKGE--IEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTAL 465
D G+ I + TF + S+ L+ +N+ + G + A+VGP GAGKS+ L
Sbjct: 424 VDSSSSGSAAGKDCITIQSATFAW-SQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLL 482
Query: 466 QLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGRE--DA 523
+ EG V+++G + V QE + +T++ EN+ +G+E
Sbjct: 483 SALLGELSKVEGFVSIEG-------------AVAYVPQEAWVQNTSVVENVCFGQELDPP 529
Query: 524 TMEDIVQA-AKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLL 582
+E +++A A + + +F P+ T +GE G +SGGQKQR+++ARA+ R + LL
Sbjct: 530 WLERVLEACALQPDVDSF----PEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLL 585
Query: 583 DMATSALD-NESEAMVQEVLSK--IQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGT 639
D +ALD + + + +V+ + G T I V H L + AD II +G E G+
Sbjct: 586 DDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGS 645
Query: 640 HEELLERKGVYFTLVTLQSQ-GNQALNEEDIKDATEDDMLARTFSRGSYQDSLRASIRQR 698
++ELL+RKG L+ Q G++ E + +T+D RG+ R+R
Sbjct: 646 YQELLQRKGALVCLLDQARQPGDRGEGETEPGTSTKDP-------RGTSAGRRPELRRER 698
Query: 699 SKSQLSYLVHEPPLAVVDHKSTYEEDRKDKDIPVQEEVEPAPVRRILKFSAPEWPY---- 754
S KS E+DR + + ++ WP
Sbjct: 699 SI-----------------KSVPEKDRTTSEAQTEVPLDDP--------DRAGWPAGKDS 733
Query: 755 MLVGSVGAAVN-------GTVTPLYA-FLF-SQILGTF-------------SIPDKEEQR 792
+ G V A V+ GT LYA FLF Q + +F ++ ++ Q
Sbjct: 734 IQYGRVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLWADDPAVGGQQTQA 793
Query: 793 SQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRN 852
+ G+ F +GC+ F A G ++ L + ++ I++F+ R
Sbjct: 794 ALRGGI---FGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFE--RT 848
Query: 853 SPGALTTRLATDASQVQGAAGSQI-GMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFP-F 910
G L R + + V ++ +++ +F + V++++A + L + P F
Sbjct: 849 PIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVA----TPLATVAILPLF 904
Query: 911 LALSGATQTRMLTGFASR--DKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELE 968
L +G +++ R + + V E V + F+ ++
Sbjct: 905 LLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVD 964
Query: 969 KPFKTAIQK--------ANIY----GFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSY 1016
+ + + + AN+ G FA A C + S G+ +S
Sbjct: 965 ESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAA----LQ 1020
Query: 1017 VFRVISAVVLSATALGRA---------FSYTPSYAKAKISAARFFQLLDRQPPISVYNTA 1067
V + + VV + T L + +++TP A ++ QPP
Sbjct: 1021 VTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCA------AQPP------- 1067
Query: 1068 GEKWDNFQGKIDFVDCKFTYPSRPDSQV-LNGLSVSISPGQTLAFVGSSGCGKSTSIQLL 1126
W G+I+F D Y RP+ + + G+S I G+ + VG +G GKS+ L
Sbjct: 1068 ---WPQ-GGQIEFQDFGLRY--RPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGL 1121
Query: 1127 ERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPME 1186
R + +G + IDG V + LRS I I+ Q+P+LF S+ N+ D +E E
Sbjct: 1122 LRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNL---DLLQEHSDE 1178
Query: 1187 RVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEAT 1246
+ AA + QL V SLP + + +G LS G+KQ + +ARA++R +IL+LDEAT
Sbjct: 1179 AIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEAT 1238
Query: 1247 SALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQ 1306
+A+D +E +Q L T ++IAHRL ++ + + VM +G V E G+ +L+AQ
Sbjct: 1239 AAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQ 1298
Query: 1307 KGAYYKL 1313
KG +Y+L
Sbjct: 1299 KGLFYRL 1305
>gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
[Homo sapiens]
Length = 1545
Score = 218 bits (554), Expect = 4e-56
Identities = 289/1244 (23%), Positives = 522/1244 (41%), Gaps = 158/1244 (12%)
Query: 144 YYAGIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDCNSVGELNTRFS 203
+ A + + + Y Q+CF + R M Y + + + + +VGE S
Sbjct: 368 FTAALIQSFCLQCYFQLCFKLGVKVRTAI-MASVYKKALTLSNLARKEY-TVGETVNLMS 425
Query: 204 DDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWK-----------LTLVIISVSPLI 252
D K+ D + F+ + S++ +L F W+ + +++I ++ ++
Sbjct: 426 VDAQKLMD-----VTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAIL 480
Query: 253 GIGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYE------- 305
+ TI + K D LK + +E++S ++ + F E ++ +
Sbjct: 481 STKSKTIQVKNMKNKDKRLK-------IMNEILSGIKILKYFAWEPSFRDQVQNLRKKEL 533
Query: 306 KNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTLVLD-EGEYTPGTLVQIFL 364
KNL+ + V V + F Y L S +LD + +T TL I L
Sbjct: 534 KNLLAFSQLQCVVIFVFQLTPVLVSVVTFSVYVLV---DSNNILDAQKAFTSITLFNI-L 589
Query: 365 SVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPII-DCMSEDGYKLDRIKGEIEFH 423
+ L + +S + +T R + +D I DC + ++F
Sbjct: 590 RFPLSMLPMMISSMLQASVSTERLEKYLGGDDLDTSAIRHDCNFDKA---------MQFS 640
Query: 424 NVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDG 483
+F + E + D+N+ I G++ A++GP G+GKS+ + + + G +T+ G
Sbjct: 641 EASFTWEHDSEATV-RDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKG 699
Query: 484 HDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMD 543
V Q+ + + TI +NI +G E E Q EA A ++
Sbjct: 700 -------------TTAYVPQQSWIQNGTIKDNILFGTE--FNEKRYQQVLEACALLPDLE 744
Query: 544 LPQQFDTL-VGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALD-NESEAMVQEVL 601
+ D +GE G +SGGQKQR+++ARA +N I LLD SA+D + + + +VL
Sbjct: 745 MLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVL 804
Query: 602 SK--IQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQSQ 659
+ G T + V H + + D I+ +GT VE+G++ LL +KG + + +
Sbjct: 805 GPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKTFLR 864
Query: 660 GNQALNEEDIKDATED----------------DMLARTFSRGSYQDSLRASIRQRSKSQL 703
E + D +E+ D + T R ++S R ++ + S+S
Sbjct: 865 HTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAASITMRR---ENSFRRTLSRSSRSNG 921
Query: 704 SYLVHEPPLAVVDHKSTYEEDR---KDKDIPVQEEVEPAPVRRILKFSAPEWPYMLVG-- 758
+L + ++ +ED K + + +E +E V KFS +G
Sbjct: 922 RHLKSLRNSLKTRNVNSLKEDEELVKGQKLIKKEFIETGKV----KFSIYLEYLQAIGLF 977
Query: 759 SVGAAVNGTVTPLYAFLFSQI-LGTFSIPDK--------EEQRSQINGVC-LLFVAMGCV 808
S+ + V AF+ S + L ++ K QR GV L +A G
Sbjct: 978 SIFFIILAFVMNSVAFIGSNLWLSAWTSDSKIFNSTDYPASQRDMRVGVYGALGLAQGIF 1037
Query: 809 SLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTRLATDASQV 868
F + F + +L K+L RA + +FD G + R A D S V
Sbjct: 1038 VFIAHFWSAFGFVHASNILHKQLLNNILRAPM----RFFDT--TPTGRIVNRFAGDISTV 1091
Query: 869 QGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASR 928
+ + F + ++ ++ + + +I+ + +S +M SR
Sbjct: 1092 DDTLPQSLRSWITCFLGI-ISTLVMICMATPVFTIIVIPLGIIYVS----VQMFYVSTSR 1146
Query: 929 DKQALEMVGQIT-----NEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQ------- 976
+ L+ V + +E +S + + ++RF++ E ++ K
Sbjct: 1147 QLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNRW 1206
Query: 977 ---KANIYGFCFAFAQCIMFIA--NSASYRYGGYLISNE---GLHFSYVFRVISAVVLSA 1028
+ + G F +M + ++ S G+++SN +++ R+ S + +
Sbjct: 1207 LAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMTSEIETNI 1266
Query: 1029 TALGRAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYP 1088
A+ R YT +A + D++PP W + +GKI F + + Y
Sbjct: 1267 VAVERITEYTKVENEAP-------WVTDKRPP--------PDWPS-KGKIQFNNYQVRY- 1309
Query: 1089 SRPDSQ-VLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKV 1147
RP+ VL G++ I + + VG +G GKS+ L R + G+++IDG D +
Sbjct: 1310 -RPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASI 1368
Query: 1148 NVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEK 1207
+ LR + I+ Q+P+LF+ S+ N+ +N + E + A + A L FV SL
Sbjct: 1369 GLHDLREKLTIIPQDPILFSGSLRMNLDPFNNYSD---EEIWKALELAHLKSFVASLQLG 1425
Query: 1208 YETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREG 1267
V G LS G++Q + + RA++R KIL+LDEAT+A+D E++ +Q +
Sbjct: 1426 LSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAH 1485
Query: 1268 RTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYY 1311
T I IAHRL TI ++D + V+ G +IE G+ EEL+ G +Y
Sbjct: 1486 CTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFY 1529
Score = 102 bits (254), Expect = 2e-21
Identities = 100/408 (24%), Positives = 179/408 (43%), Gaps = 30/408 (7%)
Query: 913 LSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFK 972
LS ++T + ++DK+ +I NE LS I+ + E F + ++ +K K
Sbjct: 480 LSTKSKTIQVKNMKNKDKRL-----KIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELK 534
Query: 973 TAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALG 1032
+ + + Q + + ++ + SN L F I+ + L
Sbjct: 535 NLLAFSQLQCVVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLS 594
Query: 1033 RAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWD-NFQGKIDFVDCKFTYPSRP 1091
S +A +S R + L +T+ + D NF + F + FT+
Sbjct: 595 MLPMMISSMLQASVSTERLEKYLGGDD----LDTSAIRHDCNFDKAMQFSEASFTWEHDS 650
Query: 1092 DSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQF 1151
++ V + +++ I GQ +A +G G GKS+ I + + G + I G
Sbjct: 651 EATVRD-VNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKG---------- 699
Query: 1152 LRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETN 1211
V Q+ + +I DNI +G E ++V+ A A L D M LP
Sbjct: 700 ---TTAYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEAC--ALLPDLEM-LPGGDLAE 753
Query: 1212 VGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTV---QVALDKAREGR 1268
+G +G LS G+KQRI++ARA ++ I LLD+ SA+D K + + + +G+
Sbjct: 754 IGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGK 813
Query: 1269 TCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVTT 1316
T +++ H + + D I V+ G ++EKG++ L+A+KG + K + T
Sbjct: 814 TRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKT 861
>gi|21729873 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 212 bits (540), Expect = 2e-54
Identities = 227/919 (24%), Positives = 400/919 (43%), Gaps = 120/919 (13%)
Query: 438 LNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQ 497
L+ +N+V+ G M + G +G+GKS+ L I EG V V G
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
Query: 498 IGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGG 557
+ V Q+ + S I ENI G +Q + + LP T +GE G
Sbjct: 574 LAYVPQQAWIVSGNIRENILMGGAYDKAR-YLQVLHCCSLNRDLELLPFGDMTEIGERGL 632
Query: 558 QMSGGQKQRVAIARALIRNPKILLLDMATSALD-NESEAMVQEVLSKIQHGHTIISVAHR 616
+SGGQKQR+++ARA+ + +I LLD SA+D + + + +E + K G T++ V H+
Sbjct: 633 NLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQ 692
Query: 617 LSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQSQGNQALNEEDIKDATEDD 676
L + II E+G E GTH EL+++KG Y L+ ++ K+AT D
Sbjct: 693 LQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI-----------QKMHKEATSDM 741
Query: 677 MLARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPL---AVVDHKSTYEEDRKDKDIP-- 731
+ QD+ + + + + +SQ E L AV +H+ T EE+ ++ +
Sbjct: 742 L----------QDTAKIAEKPKVESQALATSLEESLNGNAVPEHQLTQEEEMEEGSLSWR 791
Query: 732 -VQEEVEPAP--------------VRRILKFSAPEWPYMLVGSVGA----AVNGTVTPLY 772
++ A + + FS Y L G NGT+ L
Sbjct: 792 VYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLG 851
Query: 773 AFLFSQILGTFSIPDKEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLR 832
+ L + + +N + L+ V + +FT+ + + A +L K R
Sbjct: 852 NIADNPQLSFYQLV------YGLNALLLICVGVCSSGIFTKVTRKASTALHNKLFNKVFR 905
Query: 833 KFGFRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMII 892
+++FD + G L A D Q+ Q+ I + V M+I
Sbjct: 906 C---------PMSFFDTI--PIGRLLNCFAGDLEQLD-----QLLPIFSEQFLVLSLMVI 949
Query: 893 AFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITN----------- 941
A + L++ P++ L GA + + K+A+ + ++ N
Sbjct: 950 A------VLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHIL 1003
Query: 942 EALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANIYGFCFAFA--------QCIMF 993
+L + ++ GK FI FK N Y F + + +
Sbjct: 1004 NSLQGLSSIHVYGKTEDFISQ--------FKRLTDAQNNYLLLFLSSTRWMALRLEIMTN 1055
Query: 994 IANSASYRYGGYLISNEGLHFSYV-FRVISAVVLSATALGRAFSYTPSYAKAKISAARFF 1052
+ A + + IS+ F + ++ + S A R T + A ++
Sbjct: 1056 LVTLAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYM 1115
Query: 1053 QLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFV 1112
++ + P+ + T+ + G+I F D Y + VL+G++++I + + V
Sbjct: 1116 KMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPT-VLHGINLTIRGHEVVGIV 1174
Query: 1113 GSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMD 1172
G +G GKS+ L R +P G+++IDG D + ++ LRS + ++ Q+PVL + +I
Sbjct: 1175 GRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRF 1234
Query: 1173 NIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARA 1232
N+ D + +++ A ++ L + P+K T+V G S GE+Q + IARA
Sbjct: 1235 NLDPFDRHTD---QQIWDALERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARA 1291
Query: 1233 IVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQG 1292
++R+ KI+L+DEAT+++D E++ +Q + +A +G T +VIAHR++T+ N D I VM G
Sbjct: 1292 VLRNSKIILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNG 1351
Query: 1293 VVIEKGTHEELMAQKGAYY 1311
V+E E L + G+ +
Sbjct: 1352 KVVEFDRPEVLRKKPGSLF 1370
Score = 132 bits (331), Expect = 3e-30
Identities = 78/235 (33%), Positives = 132/235 (56%), Gaps = 4/235 (1%)
Query: 418 GEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEG 477
GEI F + Y +L+ +N+ I+ E+ +VG +G+GKS+ + R +P G
Sbjct: 1139 GEIIFQDYHMKYRDNTPT-VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197
Query: 478 MVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIR-YGREDATMEDIVQAAKEAN 536
+ +DG DI S+ ++ LR ++ ++ Q+PVL S TI N+ + R T + I A +
Sbjct: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRH--TDQQIWDALERTF 1255
Query: 537 AYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAM 596
I P++ T V E GG S G++Q + IARA++RN KI+L+D AT+++D E++ +
Sbjct: 1256 LTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTL 1315
Query: 597 VQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYF 651
+Q + + G T++ +AHR++TV D I+ +G VE E L ++ G F
Sbjct: 1316 IQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLF 1370
Score = 93.2 bits (230), Expect = 1e-18
Identities = 62/220 (28%), Positives = 110/220 (50%), Gaps = 17/220 (7%)
Query: 1096 LNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSN 1155
L+ +++ +S G L G++G GKS+ + + +G V + G +
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
Query: 1156 IGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQ 1215
+ V Q+ + + +I +NI G + R + L+ + LP T +G +
Sbjct: 574 LAYVPQQAWIVSGNIRENILMGGAYDKA---RYLQVLHCCSLNRDLELLPFGDMTEIGER 630
Query: 1216 GSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTV-QVALDKAREGRTCIVIA 1274
G LS G+KQRI++ARA+ D +I LLD+ SA+D K + + + K G+T +++
Sbjct: 631 GLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVT 690
Query: 1275 HRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLV 1314
H+L ++ I ++ G + E GTH ELM +KG Y +L+
Sbjct: 691 HQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730
>gi|15149474 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 212 bits (540), Expect = 2e-54
Identities = 227/919 (24%), Positives = 400/919 (43%), Gaps = 120/919 (13%)
Query: 438 LNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQ 497
L+ +N+V+ G M + G +G+GKS+ L I EG V V G
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
Query: 498 IGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGG 557
+ V Q+ + S I ENI G +Q + + LP T +GE G
Sbjct: 574 LAYVPQQAWIVSGNIRENILMGGAYDKAR-YLQVLHCCSLNRDLELLPFGDMTEIGERGL 632
Query: 558 QMSGGQKQRVAIARALIRNPKILLLDMATSALD-NESEAMVQEVLSKIQHGHTIISVAHR 616
+SGGQKQR+++ARA+ + +I LLD SA+D + + + +E + K G T++ V H+
Sbjct: 633 NLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQ 692
Query: 617 LSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQSQGNQALNEEDIKDATEDD 676
L + II E+G E GTH EL+++KG Y L+ ++ K+AT D
Sbjct: 693 LQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI-----------QKMHKEATSDM 741
Query: 677 MLARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPL---AVVDHKSTYEEDRKDKDIP-- 731
+ QD+ + + + + +SQ E L AV +H+ T EE+ ++ +
Sbjct: 742 L----------QDTAKIAEKPKVESQALATSLEESLNGNAVPEHQLTQEEEMEEGSLSWR 791
Query: 732 -VQEEVEPAP--------------VRRILKFSAPEWPYMLVGSVGA----AVNGTVTPLY 772
++ A + + FS Y L G NGT+ L
Sbjct: 792 VYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLG 851
Query: 773 AFLFSQILGTFSIPDKEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLR 832
+ L + + +N + L+ V + +FT+ + + A +L K R
Sbjct: 852 NIADNPQLSFYQLV------YGLNALLLICVGVCSSGIFTKVTRKASTALHNKLFNKVFR 905
Query: 833 KFGFRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMII 892
+++FD + G L A D Q+ Q+ I + V M+I
Sbjct: 906 C---------PMSFFDTI--PIGRLLNCFAGDLEQLD-----QLLPIFSEQFLVLSLMVI 949
Query: 893 AFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITN----------- 941
A + L++ P++ L GA + + K+A+ + ++ N
Sbjct: 950 A------VLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHIL 1003
Query: 942 EALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANIYGFCFAFA--------QCIMF 993
+L + ++ GK FI FK N Y F + + +
Sbjct: 1004 NSLQGLSSIHVYGKTEDFISQ--------FKRLTDAQNNYLLLFLSSTRWMALRLEIMTN 1055
Query: 994 IANSASYRYGGYLISNEGLHFSYV-FRVISAVVLSATALGRAFSYTPSYAKAKISAARFF 1052
+ A + + IS+ F + ++ + S A R T + A ++
Sbjct: 1056 LVTLAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYM 1115
Query: 1053 QLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFV 1112
++ + P+ + T+ + G+I F D Y + VL+G++++I + + V
Sbjct: 1116 KMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPT-VLHGINLTIRGHEVVGIV 1174
Query: 1113 GSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMD 1172
G +G GKS+ L R +P G+++IDG D + ++ LRS + ++ Q+PVL + +I
Sbjct: 1175 GRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRF 1234
Query: 1173 NIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARA 1232
N+ D + +++ A ++ L + P+K T+V G S GE+Q + IARA
Sbjct: 1235 NLDPFDRHTD---QQIWDALERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARA 1291
Query: 1233 IVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQG 1292
++R+ KI+L+DEAT+++D E++ +Q + +A +G T +VIAHR++T+ N D I VM G
Sbjct: 1292 VLRNSKIILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNG 1351
Query: 1293 VVIEKGTHEELMAQKGAYY 1311
V+E E L + G+ +
Sbjct: 1352 KVVEFDRPEVLRKKPGSLF 1370
Score = 132 bits (331), Expect = 3e-30
Identities = 78/235 (33%), Positives = 132/235 (56%), Gaps = 4/235 (1%)
Query: 418 GEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEG 477
GEI F + Y +L+ +N+ I+ E+ +VG +G+GKS+ + R +P G
Sbjct: 1139 GEIIFQDYHMKYRDNTPT-VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197
Query: 478 MVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIR-YGREDATMEDIVQAAKEAN 536
+ +DG DI S+ ++ LR ++ ++ Q+PVL S TI N+ + R T + I A +
Sbjct: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRH--TDQQIWDALERTF 1255
Query: 537 AYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAM 596
I P++ T V E GG S G++Q + IARA++RN KI+L+D AT+++D E++ +
Sbjct: 1256 LTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTL 1315
Query: 597 VQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYF 651
+Q + + G T++ +AHR++TV D I+ +G VE E L ++ G F
Sbjct: 1316 IQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLF 1370
Score = 93.2 bits (230), Expect = 1e-18
Identities = 62/220 (28%), Positives = 110/220 (50%), Gaps = 17/220 (7%)
Query: 1096 LNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSN 1155
L+ +++ +S G L G++G GKS+ + + +G V + G +
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
Query: 1156 IGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQ 1215
+ V Q+ + + +I +NI G + R + L+ + LP T +G +
Sbjct: 574 LAYVPQQAWIVSGNIRENILMGGAYDKA---RYLQVLHCCSLNRDLELLPFGDMTEIGER 630
Query: 1216 GSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTV-QVALDKAREGRTCIVIA 1274
G LS G+KQRI++ARA+ D +I LLD+ SA+D K + + + K G+T +++
Sbjct: 631 GLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVT 690
Query: 1275 HRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLV 1314
H+L ++ I ++ G + E GTH ELM +KG Y +L+
Sbjct: 691 HQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730
>gi|73747917 transporter 2, ATP-binding cassette, sub-family B isoform
2 [Homo sapiens]
Length = 653
Score = 206 bits (523), Expect = 2e-52
Identities = 159/529 (30%), Positives = 246/529 (46%), Gaps = 41/529 (7%)
Query: 743 RILKFSAPEWPYMLVGS---VGAAVNGTVTPLYAFLFSQILGTFSIPDKEEQRSQINGVC 799
R+LK S P+ P ++ V A + T+ P Y+ ILG D S I +C
Sbjct: 140 RLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYSGRVIDILGGDF--DPHAFASAIFFMC 197
Query: 800 LLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTT 859
L S + +G F + + R+R+ F ++L QD+ +F + + G L +
Sbjct: 198 LFSFG----SSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFFQETKT--GELNS 251
Query: 860 RLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQT 919
RL++D + + +++ S V S S +L+L+ L PF +
Sbjct: 252 RLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTLLSLLHMPFTIAAEKVYN 311
Query: 920 RMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKER----RFIEALE--------TEL 967
+ A+ GQ+ EA+ ++TV G E R+ EALE +L
Sbjct: 312 TRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDL 371
Query: 968 EKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLS 1027
E+ +++ G C G L L F + + V
Sbjct: 372 ERALYLLVRRVLHLGVQMLMLSC------GLQQMQDGELTQGSLLSFMIYQESVGSYV-- 423
Query: 1028 ATALGRAFSYTPSYAKAKISAA-RFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFT 1086
+ Y + + AA + F +DRQP + T QG + F D F
Sbjct: 424 -----QTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAP--TTLQGVVKFQDVSFA 476
Query: 1087 YPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKK 1146
YP+RPD VL GL+ ++ PG+ A VG +G GKST LL+ Y P G+V++D +
Sbjct: 477 YPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQ 536
Query: 1147 VNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPE 1206
+L S + V QEPVLF+ S+ +NI YG + E ++V+AAA+ A DF+ +
Sbjct: 537 YEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE--DDKVMAAAQAAHADDFIQEMEH 594
Query: 1207 KYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEK 1255
T+VG +GSQL+ G+KQR+AIARA+VRDP++L+LDEATSALD + E+
Sbjct: 595 GIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQ 643
Score = 204 bits (518), Expect = 6e-52
Identities = 135/428 (31%), Positives = 225/428 (52%), Gaps = 15/428 (3%)
Query: 173 KMRKFYFRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTI--CG 230
++R+ F ++R ++G+F GELN+R S D +++ + + ++ + + G
Sbjct: 224 RIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYG 283
Query: 231 FLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRT 290
F+L +LTL+ + P + A A+AG V E + ++T
Sbjct: 284 FMLSISP--RLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQT 341
Query: 291 VAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTLVLD 350
V +FG E+ EV RY++ L ++ R+ + + V ++ L + +
Sbjct: 342 VRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYL-LVRRVLHLGVQMLMLSCGLQQMQ 400
Query: 351 EGEYTPGTLVQIFLSVIVGALNLGNASPCLEAF----ATGRAAATSIFETIDRKPIIDCM 406
+GE T G+L LS ++ ++G+ L + AA +F +DR+P +
Sbjct: 401 DGELTQGSL----LSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLP-- 454
Query: 407 SEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQ 466
S ++G ++F +V+F YP+RP+ +L L ++PGE+TALVGP+G+GKST
Sbjct: 455 SPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAA 514
Query: 467 LIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATME 526
L+Q Y P G V +D I +L Q+ V QEPVLFS ++ NI YG + +
Sbjct: 515 LLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDD 574
Query: 527 DIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMAT 586
++ AA+ A+A +FI ++ T VGE G Q++ GQKQR+AIARAL+R+P++L+LD AT
Sbjct: 575 KVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEAT 634
Query: 587 SALDNESE 594
SALD + E
Sbjct: 635 SALDVQCE 642
>gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform 1
[Homo sapiens]
Length = 1437
Score = 205 bits (521), Expect = 3e-52
Identities = 217/915 (23%), Positives = 378/915 (41%), Gaps = 107/915 (11%)
Query: 436 KILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLR 495
+ L+ +++ I+ G++ + G G+GK++ + I EG + + G
Sbjct: 576 RTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISG------------ 623
Query: 496 DQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMD----------LP 545
V Q+ + + T+ +NI +G+E + YN +++ LP
Sbjct: 624 -TFAYVAQQAWILNATLRDNILFGKE-----------YDEERYNSVLNSCCLRPDLAILP 671
Query: 546 QQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALD-NESEAMVQEVLSKI 604
T +GE G +SGGQ+QR+++ARAL + I +LD SALD + + + K
Sbjct: 672 SSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKH 731
Query: 605 QHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQSQGNQAL 664
T++ V H+L + D +I + G ERGTHEEL+ G Y T+ G
Sbjct: 732 LKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGETPP 791
Query: 665 NEEDIKDATEDDMLARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKSTYEED 724
E + K T ++ +G S+ K + + E L ++ K
Sbjct: 792 VEINSKKETSGSQ-KKSQDKGPKTGSV--------KKEKAVKPEEGQLVQLEEKGQGSVP 842
Query: 725 RKDKDIPVQEEVEPAPVRRILKFSAPEWPYML-VGSVGAAVNGTVTPLYAFLFSQILGTF 783
+ +Q P I+ +ML VGS + T ++ Q G
Sbjct: 843 WSVYGVYIQAAGGPLAFLVIMAL------FMLNVGSTAFS-----TWWLSYWIKQGSGNT 891
Query: 784 --------SIPDKEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFG 835
S+ D + + ++ V L + ++G F K + RL
Sbjct: 892 TVTRGNETSVSDSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDEL 951
Query: 836 FRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAM-IIAF 894
FR +L + +FD G + R + D +V Q M + + V + +IA
Sbjct: 952 FRRILRSPMKFFDT--TPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAG 1009
Query: 895 SFSWKLSLV--ILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAG 952
F W L V ++ F L + R L + + + IT+ ++ + T+
Sbjct: 1010 VFPWFLVAVGPLVILFSVLHIVSRVLIRELKRLDNITQSPF--LSHITS-SIQGLATIHA 1066
Query: 953 IGKERRFIEALETELEK---PF-------KTAIQKANIYGFCFAFAQCIMFIANSASY-- 1000
K + F+ + L+ PF + + ++ +M +
Sbjct: 1067 YNKGQEFLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPP 1126
Query: 1001 RYGG----YLISNEGLHFSYVFRVISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLD 1056
Y G Y + GL F + R+ S T++ R Y + L
Sbjct: 1127 AYAGLAISYAVQLTGL-FQFTVRLASETEARFTSVERINHY--------------IKTLS 1171
Query: 1057 RQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSG 1116
+ P + N A +G++ F + + Y VL +S +I P + + VG +G
Sbjct: 1172 LEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPL-VLKKVSFTIKPKEKIGIVGRTG 1230
Query: 1117 CGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKY 1176
GKS+ L R + G + IDG + + LRS + I+ QEPVLF+ ++ N+
Sbjct: 1231 SGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNL-- 1288
Query: 1177 GDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRD 1236
D + +++ A ++ + + + LP K E+ V G S GE+Q + IARA++R
Sbjct: 1289 -DPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRH 1347
Query: 1237 PKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIE 1296
KIL+LDEAT+A+DTE++ +Q + +A T + IAHRL T+ +D I V+AQG V+E
Sbjct: 1348 CKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVE 1407
Query: 1297 KGTHEELMAQKGAYY 1311
T L++ + +
Sbjct: 1408 FDTPSVLLSNDSSRF 1422
Score = 151 bits (381), Expect = 5e-36
Identities = 142/547 (25%), Positives = 242/547 (44%), Gaps = 29/547 (5%)
Query: 120 NQNMTNGTRCGL---LNIESEMIKFASYYAGIAVAVLITGYIQICFWVIAAARQIQKMRK 176
N +T G + + M +AS YA +LI I+ +V R ++
Sbjct: 890 NTTVTRGNETSVSDSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHD 949
Query: 177 FYFRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFF 236
FRRI+R + +FD G + RFS D+++++ + Q +FIQ + F +G
Sbjct: 950 ELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVF--FCVGMI 1007
Query: 237 RGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKA--GVVADEVISSMR---TV 291
G +++V PL+ + ++ VS+ ELK + SS++ T+
Sbjct: 1008 AG-VFPWFLVAVGPLVIL--FSVLHIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATI 1064
Query: 292 AAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLI---FLCYALAFWYGSTLV 348
A+ + + RY++ L Q F W + + AL G +V
Sbjct: 1065 HAYNKGQEFLHRYQELLDDNQ------APFFLFTCAMRWLAVRLDLISIALITTTGLMIV 1118
Query: 349 LDEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSE 408
L G+ P + +S V L + L + R + + ++ +
Sbjct: 1119 LMHGQIPPA-YAGLAISYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTLSLEAPAR 1177
Query: 409 DGYKLDRI----KGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTA 464
K +GE+ F N Y + +L ++ IKP E +VG +G+GKS+
Sbjct: 1178 IKNKAPSPDWPQEGEVTFENAEMRYRENLPL-VLKKVSFTIKPKEKIGIVGRTGSGKSSL 1236
Query: 465 LQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDAT 524
+ R + G + +DG I + + LR ++ I+ QEPVLFS T+ N+ + T
Sbjct: 1237 GMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQ-YT 1295
Query: 525 MEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDM 584
+ I A + + I LP + ++ V E G S G++Q + IARAL+R+ KIL+LD
Sbjct: 1296 EDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDE 1355
Query: 585 ATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELL 644
AT+A+D E++ ++QE + + T++++AHRL TV +D I+ G VE T LL
Sbjct: 1356 ATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLL 1415
Query: 645 ERKGVYF 651
F
Sbjct: 1416 SNDSSRF 1422
>gi|110832837 ATP-binding cassette, sub-family C, member 9 isoform
SUR2B [Homo sapiens]
Length = 1549
Score = 201 bits (511), Expect = 4e-51
Identities = 223/908 (24%), Positives = 388/908 (42%), Gaps = 88/908 (9%)
Query: 438 LNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQ 497
L+++++ I G++T +VG G GKS+ L I EG V + + + R +
Sbjct: 688 LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSR 747
Query: 498 ----IGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDL-PQQFDTLV 552
+ Q+P L + T+ ENI +G + +A +A + +DL P T +
Sbjct: 748 NRYSVAYAAQKPWLLNATVEENITFG--SPFNKQRYKAVTDACSLQPDIDLLPFGDQTEI 805
Query: 553 GEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALD-NESEAMVQEVLSKIQHG--HT 609
GE G +SGGQ+QR+ +ARAL +N I+ LD SALD + S+ ++QE + K T
Sbjct: 806 GERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRT 865
Query: 610 IISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERK-GVYFTLVTLQSQGNQALNEED 668
++ V H+L + AD II + G+ + GT +++ + +Y TL ++ +Q L ++
Sbjct: 866 LVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKD- 924
Query: 669 IKDATEDDMLARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKSTYEEDRKDK 728
+A + + +T R Y +A + D + EED D
Sbjct: 925 -MEADQTTLERKTLRRAMYSREAKAQMEDE-----------------DEEEEEEEDEDDN 966
Query: 729 DIPVQEEVEPAPVRRILKFSAPEWPYMLVGSV-GAAVNGTVTPLYAFLFSQILGTFSIPD 787
V P + ++ ++L+ + + +V + + +SI +
Sbjct: 967 MSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINN 1026
Query: 788 --KEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIA 845
K +Q + G +L A +F + G K L ++ I
Sbjct: 1027 TGKADQTYYVAGFSILCGA----GIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIR 1082
Query: 846 WFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSF-SWKLSLVI 904
+FD G + R + D + + I + S T T+ + A S+ + +
Sbjct: 1083 FFDT--TPLGLILNRFSADTNIID----QHIPPTLESLTRSTLLCLSAIGMISYATPVFL 1136
Query: 905 LCFFPFLALSGATQTRMLTGFASRDKQALEMVGQIT-----NEALSNIRTVAGIGKERRF 959
+ P Q AS+D Q L+ Q+ +E + T+ E RF
Sbjct: 1137 VALLPLGVAFYFIQKYFRV--ASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRF 1194
Query: 960 ----IEALETE------LEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGY---- 1005
+E +T L + + + G C I I+ S++ G
Sbjct: 1195 KQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLY 1254
Query: 1006 --LISNEGLHFSYVFRVISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLDRQPPISV 1063
I+N + ++V R ++ + + A+ + S+ + + + +D
Sbjct: 1255 ALTITN---YLNWVVRNLADLEVQMGAVKKVNSFLT------MESENYEGTMDP------ 1299
Query: 1064 YNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSI 1123
+ E W +G+I D Y + VL + I PGQ + G +G GKS+
Sbjct: 1300 -SQVPEHWPQ-EGEIKIHDLCVRYENNL-KPVLKHVKAYIKPGQKVGICGRTGSGKSSLS 1356
Query: 1124 QLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEI 1183
R D GK++IDG D K+ + LRS + I+ Q+P+LF+ SI N+ D +
Sbjct: 1357 LAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNL---DPECKC 1413
Query: 1184 PMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLD 1243
+R+ A + AQL + V SLP + V G S G++Q +ARA VR IL++D
Sbjct: 1414 TDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMD 1473
Query: 1244 EATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEEL 1303
EAT+++D +E +Q + A RT + IAHR+ TI AD++ VM +G ++E T E L
Sbjct: 1474 EATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESL 1533
Query: 1304 MAQKGAYY 1311
+AQ+ +
Sbjct: 1534 LAQENGVF 1541
Score = 135 bits (340), Expect = 3e-31
Identities = 78/239 (32%), Positives = 134/239 (56%), Gaps = 3/239 (1%)
Query: 417 KGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCE 476
+GEI+ H++ Y + + +L + IKPG+ + G +G+GKS+ R D +
Sbjct: 1309 EGEIKIHDLCVRYENNLK-PVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFD 1367
Query: 477 GMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEAN 536
G + +DG DI L + LR ++ I+ Q+P+LFS +I N+ + T + + +A + A
Sbjct: 1368 GKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECK-CTDDRLWEALEIAQ 1426
Query: 537 AYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAM 596
N + LP D +V EGG S GQ+Q +ARA +R IL++D AT+++D +E +
Sbjct: 1427 LKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENI 1486
Query: 597 VQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELL-ERKGVYFTLV 654
+Q+V+ T++++AHR+ T+ AD +I + G +E T E LL + GV+ + V
Sbjct: 1487 LQKVVMTAFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQENGVFASFV 1545
Score = 91.7 bits (226), Expect = 4e-18
Identities = 62/224 (27%), Positives = 112/224 (50%), Gaps = 10/224 (4%)
Query: 1096 LNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRS- 1154
L+ + + I GQ VG GCGKS+ + + +GKV + + + + RS
Sbjct: 688 LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSR 747
Query: 1155 ---NIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETN 1211
++ +Q+P L ++ +NI +G + +R A L + LP +T
Sbjct: 748 NRYSVAYAAQKPWLLNATVEENITFGSPFNK---QRYKAVTDACSLQPDIDLLPFGDQTE 804
Query: 1212 VGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTE-SEKTVQVALDK--AREGR 1268
+G +G LS G++QRI +ARA+ ++ I+ LD+ SALD S+ +Q + K + R
Sbjct: 805 IGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKR 864
Query: 1269 TCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYK 1312
T +++ H+L + +AD I M G V+ +GT +++ + Y+
Sbjct: 865 TLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYE 908
>gi|110832839 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A-delta-14 [Homo sapiens]
Length = 1513
Score = 199 bits (505), Expect = 2e-50
Identities = 224/914 (24%), Positives = 392/914 (42%), Gaps = 89/914 (9%)
Query: 438 LNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQ 497
L+++++ I G++T +VG G GKS+ L I EG V + + + R +
Sbjct: 652 LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSR 711
Query: 498 ----IGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDL-PQQFDTLV 552
+ Q+P L + T+ ENI +G + +A +A + +DL P T +
Sbjct: 712 NRYSVAYAAQKPWLLNATVEENITFG--SPFNKQRYKAVTDACSLQPDIDLLPFGDQTEI 769
Query: 553 GEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALD-NESEAMVQEVLSKIQHG--HT 609
GE G +SGGQ+QR+ +ARAL +N I+ LD SALD + S+ ++QE + K T
Sbjct: 770 GERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRT 829
Query: 610 IISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERK-GVYFTLVTLQSQGNQALNEED 668
++ V H+L + AD II + G+ + GT +++ + +Y TL ++ +Q L ++
Sbjct: 830 LVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKD- 888
Query: 669 IKDATEDDMLARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKSTYEEDRKDK 728
+A + + +T R Y +A + D + EED D
Sbjct: 889 -MEADQTTLERKTLRRAMYSREAKAQMEDE-----------------DEEEEEEEDEDDN 930
Query: 729 DIPVQEEVEPAPVRRILKFSAPEWPYMLVGSV-GAAVNGTVTPLYAFLFSQILGTFSIPD 787
V P + ++ ++L+ + + +V + + +SI +
Sbjct: 931 MSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINN 990
Query: 788 --KEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIA 845
K +Q + G +L A +F + G K L ++ I
Sbjct: 991 TGKADQTYYVAGFSILCGA----GIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIR 1046
Query: 846 WFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSF-SWKLSLVI 904
+FD G + R + D + + I + S T T+ + A S+ + +
Sbjct: 1047 FFDT--TPLGLILNRFSADTNIID----QHIPPTLESLTRSTLLCLSAIGMISYATPVFL 1100
Query: 905 LCFFPFLALSGATQTRMLTGFASRDKQALEMVGQIT-----NEALSNIRTVAGIGKERRF 959
+ P Q AS+D Q L+ Q+ +E + T+ E RF
Sbjct: 1101 VALLPLGVAFYFIQKYFRV--ASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRF 1158
Query: 960 ----IEALETE------LEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGY---- 1005
+E +T L + + + G C I I+ S++ G
Sbjct: 1159 KQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLY 1218
Query: 1006 --LISNEGLHFSYVFRVISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLDRQPPISV 1063
I+N + ++V R ++ + + A+ + S+ + + + +D
Sbjct: 1219 ALTITN---YLNWVVRNLADLEVQMGAVKKVNSFLT------MESENYEGTMDP------ 1263
Query: 1064 YNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSI 1123
+ E W +G+I D Y + VL + I PGQ + G +G GKS+
Sbjct: 1264 -SQVPEHWPQ-EGEIKIHDLCVRYENNL-KPVLKHVKAYIKPGQKVGICGRTGSGKSSLS 1320
Query: 1124 QLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEI 1183
R D GK++IDG D K+ + LRS + I+ Q+P+LF+ SI N+ D +
Sbjct: 1321 LAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNL---DPECKC 1377
Query: 1184 PMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLD 1243
+R+ A + AQL + V SLP + V G S G++Q +ARA VR IL++D
Sbjct: 1378 TDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMD 1437
Query: 1244 EATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEEL 1303
EAT+++D +E +Q + A RT + IAHR+S+I +A ++ V ++G+++E T L
Sbjct: 1438 EATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNL 1497
Query: 1304 MAQK-GAYYKLVTT 1316
+A K G + LV T
Sbjct: 1498 LAHKNGLFSTLVMT 1511
Score = 134 bits (337), Expect = 6e-31
Identities = 79/239 (33%), Positives = 134/239 (56%), Gaps = 3/239 (1%)
Query: 417 KGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCE 476
+GEI+ H++ Y + + +L + IKPG+ + G +G+GKS+ R D +
Sbjct: 1273 EGEIKIHDLCVRYENNLK-PVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFD 1331
Query: 477 GMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEAN 536
G + +DG DI L + LR ++ I+ Q+P+LFS +I N+ + T + + +A + A
Sbjct: 1332 GKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECK-CTDDRLWEALEIAQ 1390
Query: 537 AYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAM 596
N + LP D +V EGG S GQ+Q +ARA +R IL++D AT+++D +E +
Sbjct: 1391 LKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENI 1450
Query: 597 VQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERK-GVYFTLV 654
+Q+V+ T++++AHR+S++ A ++ F G VE T LL K G++ TLV
Sbjct: 1451 LQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLV 1509
Score = 94.4 bits (233), Expect = 7e-19
Identities = 94/393 (23%), Positives = 165/393 (41%), Gaps = 35/393 (8%)
Query: 940 TNEALSNIRTVAGIGKERRFIEALETELEKPF---KTAIQKANIYGFCFAFAQCIMFIAN 996
TNE L I+ + E F +++E K KT ++ F A +A
Sbjct: 495 TNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLAT 554
Query: 997 SASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLD 1056
++ Y S L + F +S + T L + KA IS + + L
Sbjct: 555 FVTHAYA----SGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFLL 610
Query: 1057 RQPPISVYNTAGEKWDNFQGKIDFVDCK----------FTYPSRPDSQVLNGLSVSISPG 1106
+ W + + F CK F++ S L+ + + I G
Sbjct: 611 SD------EIGDDSWRTGESSLPFESCKKHTGVVTNGYFSWGS--GLATLSNIDIRIPTG 662
Query: 1107 QTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRS----NIGIVSQE 1162
Q VG GCGKS+ + + +GKV + + + + RS ++ +Q+
Sbjct: 663 QLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQK 722
Query: 1163 PVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRG 1222
P L ++ +NI +G + +R A L + LP +T +G +G LS G
Sbjct: 723 PWLLNATVEENITFGSPFNK---QRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGG 779
Query: 1223 EKQRIAIARAIVRDPKILLLDEATSALDTE-SEKTVQVALDK--AREGRTCIVIAHRLST 1279
++QRI +ARA+ ++ I+ LD+ SALD S+ +Q + K + RT +++ H+L
Sbjct: 780 QRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQY 839
Query: 1280 IQNADIIAVMAQGVVIEKGTHEELMAQKGAYYK 1312
+ +AD I M G V+ +GT +++ + Y+
Sbjct: 840 LTHADWIIAMKDGSVLREGTLKDIQTKDVELYE 872
>gi|110832835 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A [Homo sapiens]
Length = 1549
Score = 199 bits (505), Expect = 2e-50
Identities = 224/914 (24%), Positives = 392/914 (42%), Gaps = 89/914 (9%)
Query: 438 LNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQ 497
L+++++ I G++T +VG G GKS+ L I EG V + + + R +
Sbjct: 688 LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSR 747
Query: 498 ----IGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDL-PQQFDTLV 552
+ Q+P L + T+ ENI +G + +A +A + +DL P T +
Sbjct: 748 NRYSVAYAAQKPWLLNATVEENITFG--SPFNKQRYKAVTDACSLQPDIDLLPFGDQTEI 805
Query: 553 GEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALD-NESEAMVQEVLSKIQHG--HT 609
GE G +SGGQ+QR+ +ARAL +N I+ LD SALD + S+ ++QE + K T
Sbjct: 806 GERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRT 865
Query: 610 IISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERK-GVYFTLVTLQSQGNQALNEED 668
++ V H+L + AD II + G+ + GT +++ + +Y TL ++ +Q L ++
Sbjct: 866 LVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKD- 924
Query: 669 IKDATEDDMLARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKSTYEEDRKDK 728
+A + + +T R Y +A + D + EED D
Sbjct: 925 -MEADQTTLERKTLRRAMYSREAKAQMEDE-----------------DEEEEEEEDEDDN 966
Query: 729 DIPVQEEVEPAPVRRILKFSAPEWPYMLVGSV-GAAVNGTVTPLYAFLFSQILGTFSIPD 787
V P + ++ ++L+ + + +V + + +SI +
Sbjct: 967 MSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINN 1026
Query: 788 --KEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIA 845
K +Q + G +L A +F + G K L ++ I
Sbjct: 1027 TGKADQTYYVAGFSILCGA----GIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIR 1082
Query: 846 WFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSF-SWKLSLVI 904
+FD G + R + D + + I + S T T+ + A S+ + +
Sbjct: 1083 FFDT--TPLGLILNRFSADTNIID----QHIPPTLESLTRSTLLCLSAIGMISYATPVFL 1136
Query: 905 LCFFPFLALSGATQTRMLTGFASRDKQALEMVGQIT-----NEALSNIRTVAGIGKERRF 959
+ P Q AS+D Q L+ Q+ +E + T+ E RF
Sbjct: 1137 VALLPLGVAFYFIQKYFRV--ASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRF 1194
Query: 960 ----IEALETE------LEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGY---- 1005
+E +T L + + + G C I I+ S++ G
Sbjct: 1195 KQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLY 1254
Query: 1006 --LISNEGLHFSYVFRVISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLDRQPPISV 1063
I+N + ++V R ++ + + A+ + S+ + + + +D
Sbjct: 1255 ALTITN---YLNWVVRNLADLEVQMGAVKKVNSFLT------MESENYEGTMDP------ 1299
Query: 1064 YNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSI 1123
+ E W +G+I D Y + VL + I PGQ + G +G GKS+
Sbjct: 1300 -SQVPEHWPQ-EGEIKIHDLCVRYENNL-KPVLKHVKAYIKPGQKVGICGRTGSGKSSLS 1356
Query: 1124 QLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEI 1183
R D GK++IDG D K+ + LRS + I+ Q+P+LF+ SI N+ D +
Sbjct: 1357 LAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNL---DPECKC 1413
Query: 1184 PMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLD 1243
+R+ A + AQL + V SLP + V G S G++Q +ARA VR IL++D
Sbjct: 1414 TDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMD 1473
Query: 1244 EATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEEL 1303
EAT+++D +E +Q + A RT + IAHR+S+I +A ++ V ++G+++E T L
Sbjct: 1474 EATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNL 1533
Query: 1304 MAQK-GAYYKLVTT 1316
+A K G + LV T
Sbjct: 1534 LAHKNGLFSTLVMT 1547
Score = 134 bits (337), Expect = 6e-31
Identities = 79/239 (33%), Positives = 134/239 (56%), Gaps = 3/239 (1%)
Query: 417 KGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCE 476
+GEI+ H++ Y + + +L + IKPG+ + G +G+GKS+ R D +
Sbjct: 1309 EGEIKIHDLCVRYENNLK-PVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFD 1367
Query: 477 GMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEAN 536
G + +DG DI L + LR ++ I+ Q+P+LFS +I N+ + T + + +A + A
Sbjct: 1368 GKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECK-CTDDRLWEALEIAQ 1426
Query: 537 AYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAM 596
N + LP D +V EGG S GQ+Q +ARA +R IL++D AT+++D +E +
Sbjct: 1427 LKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENI 1486
Query: 597 VQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERK-GVYFTLV 654
+Q+V+ T++++AHR+S++ A ++ F G VE T LL K G++ TLV
Sbjct: 1487 LQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLV 1545
>gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform 1
[Homo sapiens]
Length = 1527
Score = 198 bits (504), Expect = 2e-50
Identities = 267/1188 (22%), Positives = 491/1188 (41%), Gaps = 142/1188 (11%)
Query: 193 NSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWK-----------L 241
++VGE+ S D + D +A F+ + S +L + W+
Sbjct: 404 STVGEIVNLMSVDAQRFMD-----LAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAF 458
Query: 242 TLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREV 301
+++I ++ + + + K D +K + E+++ ++ + + E +
Sbjct: 459 MVLLIPLNGAVAVKMRAFQVKQMKLKDSRIK-------LMSEILNGIKVLKLYAWEPSFL 511
Query: 302 ERYEKNLVFAQRWGIRKGIVMGFFTGFVW-CLIFLCYALAFWY----GSTLVLD-EGEYT 355
++ E + + +R + T F W C FL + W VLD E +
Sbjct: 512 KQVE-GIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFV 570
Query: 356 PGTLVQIF---LSVIVGAL-NLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGY 411
+L I L+++ + NL AS L+ + ++++RK I GY
Sbjct: 571 SVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKTI-----SPGY 625
Query: 412 KLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRF 471
I H+ TF + ++ L+ L++ + G + A+VGP G GKS+ + +
Sbjct: 626 A-------ITIHSGTFTW-AQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGE 677
Query: 472 YDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQA 531
+ EG V + G + V Q+ + + T+ EN+ +G+ A Q
Sbjct: 678 MEKLEGKVHMKG-------------SVAYVPQQAWIQNCTLQENVLFGK--ALNPKRYQQ 722
Query: 532 AKEANAYNFIMD-LPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALD 590
EA A ++ LP T +GE G +SGGQ+QRV++ARA+ + I LLD SA+D
Sbjct: 723 TLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVD 782
Query: 591 NE-SEAMVQEVLSK--IQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERK 647
+ ++ + V+ + G T + V H +S + D II G E G + LL+R
Sbjct: 783 SHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRN 842
Query: 648 GVYFTLVTL----QSQGN-----QALNEEDIKDATEDDMLARTFSRGSYQDSLRASIRQR 698
G + + + QG+ AL + K+A + + + D + ++++
Sbjct: 843 GSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQ 902
Query: 699 SKSQLSYLVHE--------PPLAVVDHKSTYEEDRKDKDIPVQEEVEPAPVRRILKFSAP 750
QLS L + P + + + K QEE + F
Sbjct: 903 FMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVF--- 959
Query: 751 EWPYMLVGSVGAAVNGTVTPLYAFLFSQILGTF---------SIPDKEEQRSQIN-GVCL 800
W Y +VG + LY + +G ++ D + + + GV
Sbjct: 960 -WDY--AKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGV-- 1014
Query: 801 LFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTR 860
+ A+G + F L A A G + L + + ++FD + G +
Sbjct: 1015 -YAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPS--GRILNC 1071
Query: 861 LATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTR 920
+ D V I M++NSF N +++ + + ++VIL P L T +
Sbjct: 1072 FSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVIL---PLAVLY--TLVQ 1126
Query: 921 MLTGFASRDKQALEMVGQITNEALSNI-RTVAGIGKERRFIEALETELEKPFKTAIQKAN 979
SR + LE V + + S+ TV G R + + + E+ K + +
Sbjct: 1127 RFYAATSRQLKRLESVSR--SPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRS 1184
Query: 980 IYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRAFSYTP 1039
C +I ++ G + N + F+ +F VI L+ +G + SY+
Sbjct: 1185 ----------CYPYIISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSL 1234
Query: 1040 SYAKA----------------KISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDC 1083
A + + + + + P V + + +G+++F +
Sbjct: 1235 QVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNY 1294
Query: 1084 KFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHD 1143
Y D VL LS+ + G+ + VG +G GKS+ L R + +G++ IDG +
Sbjct: 1295 SVRYRPGLDL-VLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLN 1353
Query: 1144 SKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMS 1203
+ + LRS + I+ Q+P+LF+ ++ N+ + E E + A + + LH FV S
Sbjct: 1354 VADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSE---EDIWWALELSHLHTFVSS 1410
Query: 1204 LPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDK 1263
P + G LS G++Q + +ARA++R +IL+LDEAT+A+D E++ +Q +
Sbjct: 1411 QPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRT 1470
Query: 1264 AREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYY 1311
+ T + IAHRL+TI + + V+ +GVV E + L+A +G +Y
Sbjct: 1471 QFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIFY 1518
Score = 101 bits (252), Expect = 4e-21
Identities = 107/475 (22%), Positives = 201/475 (42%), Gaps = 37/475 (7%)
Query: 855 GALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWK-LSLVILCFFPFLAL 913
G + ++ DA + A +N + + +I+A F W+ L +L F+ L
Sbjct: 407 GEIVNLMSVDAQRFMDLAP-----FLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVL 461
Query: 914 ----SGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEK 969
+GA +M F + + + ++ +E L+ I+ + E F++ +E +
Sbjct: 462 LIPLNGAVAVKM-RAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQG 520
Query: 970 PFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSAT 1029
+ A ++ C F+ + Y+ N L F +S +
Sbjct: 521 ELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRL 580
Query: 1030 ALGRAFSYTPSYAKAKISAARFFQLLDRQP--PISVYNTAGEKWDNFQGKIDFVDCKFTY 1087
L + +A +S R Q L ++ P SV K + I FT+
Sbjct: 581 PLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVER----KTISPGYAITIHSGTFTW 636
Query: 1088 PSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKV 1147
++ L+ L + + G +A VG GCGKS+ + L + +GKV + G
Sbjct: 637 -AQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKG------ 689
Query: 1148 NVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEK 1207
++ V Q+ + C++ +N+ +G ++ + A A L D M LP
Sbjct: 690 -------SVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEAC--ALLADLEM-LPGG 739
Query: 1208 YETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTV---QVALDKA 1264
+T +G +G LS G++QR+++ARA+ D I LLD+ SA+D+ K + + +
Sbjct: 740 DQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGV 799
Query: 1265 REGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVTTGSP 1319
G+T +++ H +S + D I V+A G V E G + L+ + G++ + +P
Sbjct: 800 LAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAP 854
>gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo
sapiens]
Length = 753
Score = 191 bits (484), Expect = 5e-48
Identities = 155/511 (30%), Positives = 246/511 (48%), Gaps = 24/511 (4%)
Query: 811 FTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQG 870
F ++ F K + +R+ K F + D+ + L GAL+ + +
Sbjct: 206 FFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLGFH--LSRQTGALSKAIDRGTRGISF 263
Query: 871 AAGSQI-GMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASRD 929
+ + ++ F + V+ ++ + + +LV L TR T F
Sbjct: 264 VLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEM 323
Query: 930 KQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANIYGFCFAFAQ 989
+A G ++L N TV ER + + L K ++TA K+ F Q
Sbjct: 324 NKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGFL-KTYETASLKSTSTLAMLNFGQ 382
Query: 990 CIMFIANSASYRYGGYLISNEGL--------HFSYVFRVISAVVLSATALGRAFSYTPSY 1041
+F + +++++G+ V ++ + L LG + T
Sbjct: 383 SAIFSVGLTAIM----VLASQGIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRET--- 435
Query: 1042 AKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQ-GKIDFVDCKFTYPSRPDSQVLNGLS 1100
+A I F LL I A Q + F + F Y +VL+G+S
Sbjct: 436 RQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHFEYIE--GQKVLSGIS 493
Query: 1101 VSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVS 1160
+ G+ +A VG SG GKST ++LL RFY+P +G + + G + + V+++ LR +G+V
Sbjct: 494 FEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVP 553
Query: 1161 QEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLS 1220
Q+ VLF +I N+ YG N P E V A AK A LHD ++ +P Y+T VG +G +LS
Sbjct: 554 QDAVLFHNTIYYNLLYG-NISASP-EEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLS 611
Query: 1221 RGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTI 1280
GEKQR+AIARAI++DP ++L DEATS+LD+ +E+T+ A+ + RT I IAHRLST+
Sbjct: 612 GGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIFIAHRLSTV 671
Query: 1281 QNADIIAVMAQGVVIEKGTHEELMAQKGAYY 1311
+AD I V+ QG V E+GTH L+A + Y
Sbjct: 672 VDADEIIVLDQGKVAERGTHHGLLANPHSIY 702
Score = 183 bits (464), Expect = 1e-45
Identities = 126/426 (29%), Positives = 216/426 (50%), Gaps = 5/426 (1%)
Query: 272 KAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWC 331
KA AG A + + + TV F E+ E +RY+ L + ++ + F
Sbjct: 325 KADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGFLKTYETASLKSTSTLAMLN-FGQS 383
Query: 332 LIFLCYALAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAAT 391
IF A ++ + G T G LV + + +L L
Sbjct: 384 AIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMN 443
Query: 392 SIFETID-RKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEM 450
++F + I D + ++ + F NV F Y K+L+ ++ + G+
Sbjct: 444 TLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHFEYIEGQ--KVLSGISFEVPAGKK 501
Query: 451 TALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFST 510
A+VG SG+GKST ++L+ RFY+P +G + + G +I+ ++++ LR +G+V Q+ VLF
Sbjct: 502 VAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHN 561
Query: 511 TIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIA 570
TI N+ YG A+ E++ AK A ++ I+ +P +DT VGE G ++SGG+KQRVAIA
Sbjct: 562 TIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIA 621
Query: 571 RALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFE 630
RA++++P ++L D ATS+LD+ +E + + + T I +AHRLSTV AD II +
Sbjct: 622 RAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLD 681
Query: 631 HGTAVERGTHEELLERKGVYFTLVTLQSQGNQALNEEDIKDATEDDMLARTFSRGSYQDS 690
G ERGTH LL ++ + +Q ++ N ++ K + + +++ R Q+
Sbjct: 682 QGKVAERGTHHGLLANPHSIYSEM-WHTQSSRVQNHDNPKWEAKKENISKEEERKKLQEE 740
Query: 691 LRASIR 696
+ S++
Sbjct: 741 IVNSVK 746
>gi|134142340 ATP-binding cassette, sub-family C, member 1 isoform 2
[Homo sapiens]
Length = 1472
Score = 189 bits (480), Expect = 2e-47
Identities = 202/800 (25%), Positives = 354/800 (44%), Gaps = 82/800 (10%)
Query: 556 GGQMSGGQKQRVAIARALIRNPKILLLDMATSALD-NESEAMVQEVLSK--IQHGHTIIS 612
G +SGGQKQRV++ARA+ N I L D SA+D + + + + V+ + T I
Sbjct: 706 GVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRIL 765
Query: 613 VAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVY--FTLVTLQSQGNQALNEEDIK 670
V H +S + D II G E G+++ELL R G + F ++ Q E +
Sbjct: 766 VTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVT 825
Query: 671 DATEDDMLARTFSRGSY-QDSLRASIRQRSKSQLSYLVHEPPLAVVDHKSTYE----EDR 725
+ A+ G DS ++++ S SY H ST E E +
Sbjct: 826 GVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISR----HHNSTAELQKAEAK 881
Query: 726 KDKDIPVQEEVEPAPVRRILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQILGTFS- 784
K++ + E + A ++ K S W YM ++G ++ ++ F+ + + S
Sbjct: 882 KEETWKLME-ADKAQTGQV-KLSV-YWDYMK--AIGLFIS--FLSIFLFMCNHVSALASN 934
Query: 785 ----------IPDKEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKF 834
I + ++ +++ ++ A+G F A + G L ++ L
Sbjct: 935 YWLSLWTDDPIVNGTQEHTKVR--LSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVD 992
Query: 835 GFRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAF 894
++L +++F+ R G L R + + V I M + S NV A I+
Sbjct: 993 LLHSILRSPMSFFE--RTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVIL 1050
Query: 895 SFSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQIT-----NEALSNIRT 949
+ +++I P L L R +SR + LE V + NE L +
Sbjct: 1051 LATPIAAIII----PPLGLIYFFVQRFYVA-SSRQLKRLESVSRSPVYSHFNETLLGVSV 1105
Query: 950 VAGIGKERRFIEALETELEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISN 1009
+ ++ RFI + ++++ K + +C+ N
Sbjct: 1106 IRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECV----------------GN 1149
Query: 1010 EGLHFSYVFRVISAVVLSATALGRAFSYT-------------PSYAKAKISAA---RFFQ 1053
+ F+ +F VIS LSA +G + SY+ S + I A + +
Sbjct: 1150 CIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYS 1209
Query: 1054 LLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVG 1113
+++ P + TA G+++F + Y D VL ++V+I+ G+ + VG
Sbjct: 1210 ETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVG 1268
Query: 1114 SSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDN 1173
+G GKS+ L R + +G+++IDG + K+ + LR I I+ Q+PVLF+ S+ N
Sbjct: 1269 RTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMN 1328
Query: 1174 IKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAI 1233
+ D + E V + + A L DFV +LP+K + G LS G++Q + +ARA+
Sbjct: 1329 L---DPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARAL 1385
Query: 1234 VRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGV 1293
+R KIL+LDEAT+A+D E++ +Q + E T + IAHRL+TI + + V+ +G
Sbjct: 1386 LRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGE 1445
Query: 1294 VIEKGTHEELMAQKGAYYKL 1313
+ E G +L+ Q+G +Y +
Sbjct: 1446 IQEYGAPSDLLQQRGLFYSM 1465
Score = 139 bits (350), Expect = 2e-32
Identities = 135/555 (24%), Positives = 255/555 (45%), Gaps = 40/555 (7%)
Query: 114 WTNSSLNQNMTNGTRCGLLNIESEMIKFASYYA-GIAVAVLITGY-IQICFWVIAAARQI 171
W + + + NGT+ E ++ + Y A GI+ + + GY + + I A+R +
Sbjct: 936 WLSLWTDDPIVNGTQ------EHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCL 989
Query: 172 QKMRKFYFRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGF 231
I+R + +F+ G L RFS +++ ++ I + + +F+ + + I G
Sbjct: 990 HVD---LLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVI-GA 1045
Query: 232 LLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVA--DEVISSMR 289
+ + +II LI ++ S+ L++ +++ V + +E + +
Sbjct: 1046 CIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLK-RLESVSRSPVYSHFNETLLGVS 1104
Query: 290 TVAAFGGEKREVERYEKNL----------VFAQRW-GIRKGIVMGFFTGFVWCLIFLCYA 338
+ AF ++R + + + + + A RW +R V C++ +A
Sbjct: 1105 VIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGN-------CIVL--FA 1155
Query: 339 LAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIFETID 398
F S L G G V L V L S +E ET
Sbjct: 1156 ALFAVISRHSLSAG--LVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEK 1213
Query: 399 RKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSG 458
P + ++ G +EF N Y + +L +N+ I GE +VG +G
Sbjct: 1214 EAPWQIQETAPPSSWPQV-GRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTG 1271
Query: 459 AGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRY 518
AGKS+ + R + EG + +DG +I + + LR +I I+ Q+PVLFS ++ N+
Sbjct: 1272 AGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDP 1331
Query: 519 GREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPK 578
+ + E++ + + A+ +F+ LP + D EGG +S GQ+Q V +ARAL+R K
Sbjct: 1332 FSQYSD-EEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTK 1390
Query: 579 ILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERG 638
IL+LD AT+A+D E++ ++Q + T++++AHRL+T+ +I + G E G
Sbjct: 1391 ILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYG 1450
Query: 639 THEELLERKGVYFTL 653
+LL+++G+++++
Sbjct: 1451 APSDLLQQRGLFYSM 1465
Score = 70.9 bits (172), Expect = 8e-12
Identities = 43/145 (29%), Positives = 79/145 (54%), Gaps = 8/145 (5%)
Query: 1180 TKEIPMERVIAAAKQ-----AQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIV 1234
T IP ++A Q + L +++ +K E +V +G LS G+KQR+++ARA+
Sbjct: 665 TFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGVNLSGGQKQRVSLARAVY 724
Query: 1235 RDPKILLLDEATSALDTESEKTV---QVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQ 1291
+ I L D+ SA+D K + + + +T I++ H +S + D+I VM+
Sbjct: 725 SNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSG 784
Query: 1292 GVVIEKGTHEELMAQKGAYYKLVTT 1316
G + E G+++EL+A+ GA+ + + T
Sbjct: 785 GKISEMGSYQELLARDGAFAEFLRT 809
Score = 42.0 bits (97), Expect = 0.004
Identities = 24/57 (42%), Positives = 32/57 (56%), Gaps = 1/57 (1%)
Query: 1085 FTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDG 1141
FT+ +R D LNG++ SI G +A VG GCGKS+ + L D +G V I G
Sbjct: 651 FTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG 706
>gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo
sapiens]
Length = 1581
Score = 185 bits (470), Expect = 2e-46
Identities = 224/931 (24%), Positives = 397/931 (42%), Gaps = 104/931 (11%)
Query: 435 VKILNDLNMVIKPGEMTALVGPSGAGKST----ALQLIQRFY---------------DPC 475
+ L+++ + I G++T +VG G GKS+ AL +Q+ DP
Sbjct: 693 IPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPS 752
Query: 476 EGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEA 535
T DIR R + Q+P L + T+ ENI + E + + EA
Sbjct: 753 PERETATDLDIRK------RGPVAYASQKPWLLNATVEENIIF--ESPFNKQRYKMVIEA 804
Query: 536 NAYNFIMD-LPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALD-NES 593
+ +D LP T +GE G +SGGQ+QR+++ARAL ++ ++ LD SALD + S
Sbjct: 805 CSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLS 864
Query: 594 EAMVQEVLSKIQHG--HTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYF 651
+ ++Q + ++ T++ V H+L + AD II + GT GT ++ + F
Sbjct: 865 DHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLF 924
Query: 652 T-LVTLQSQGNQALNEEDIKD--ATEDDM-LARTFSR--GSYQDSLRASIRQRSKSQLSY 705
TL ++ +Q L +E + + ATE L+R S G QD + + + +
Sbjct: 925 EHWKTLMNRQDQELEKETVTERKATEPPQGLSRAMSSRDGLLQDE------EEEEEEAAE 978
Query: 706 LVHEPPLAVVDHKSTYEEDRKDKDIPVQEEVEPAPVRRILKFSAPEWPYMLVGSVGAAVN 765
+ L+ + H+ +IP + + IL S + +L V A++
Sbjct: 979 SEEDDNLSSMLHQRA--------EIPWRACAKYLSSAGILLLSLLVFSQLLKHMVLVAID 1030
Query: 766 GTVTPLYAFLFSQILGTFSIPDKEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGE 825
+ + + +E ++F + + + + +G
Sbjct: 1031 YWLAKWTDSALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGIVLCLVTSVTVEWTGL 1090
Query: 826 LLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTN 885
+ KRL + ++ + +F+ G++ R ++D + + S + + S T
Sbjct: 1091 KVAKRLHRSLLNRIILAPMRFFET--TPLGSILNRFSSDCNTIDQHIPSTLECLSRS-TL 1147
Query: 886 VTVAMIIAFSFSWKLSLV------ILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQI 939
+ V+ + S+ + LV I+C+F + ASRD Q L+ Q+
Sbjct: 1148 LCVSALAVISYVTPVFLVALLPLAIVCYF----------IQKYFRVASRDLQQLDDTTQL 1197
Query: 940 T-----NEALSNIRTVAGIGKERRFIEAL-----ETELEKPFKTAIQK-----ANIYGFC 984
E + + T+ E RF + L + F TA + G C
Sbjct: 1198 PLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGAC 1257
Query: 985 FAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALG----RAFSYTPS 1040
+ I+NS L+ GL +Y V + + L + +
Sbjct: 1258 VVLIAAVTSISNSLHRELSAGLV---GLGLTYALMVSNYLNWMVRNLADMELQLGAVKRI 1314
Query: 1041 YAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLS 1100
+ K A + LL P + N W + QGKI + Y S VL ++
Sbjct: 1315 HGLLKTEAESYEGLL--APSLIPKN-----WPD-QGKIQIQNLSVRYDSSL-KPVLKHVN 1365
Query: 1101 VSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVS 1160
I+PGQ + G +G GKS+ R D +G ++IDG D K+ + LRS + I+
Sbjct: 1366 ALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIIL 1425
Query: 1161 QEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLS 1220
Q+PVLF+ +I N+ D ++ + A + AQL V +LP + + G S
Sbjct: 1426 QDPVLFSGTIRFNL---DPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFS 1482
Query: 1221 RGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTI 1280
+G++Q +ARA VR I ++DEAT+++D +E +Q + A RT + IAHR+ TI
Sbjct: 1483 QGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTI 1542
Query: 1281 QNADIIAVMAQGVVIEKGTHEELMAQKGAYY 1311
+AD++ V+ +G ++E E+L+++K + +
Sbjct: 1543 LSADLVIVLKRGAILEFDKPEKLLSRKDSVF 1573
Score = 134 bits (336), Expect = 8e-31
Identities = 78/237 (32%), Positives = 134/237 (56%), Gaps = 6/237 (2%)
Query: 417 KGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCE 476
+G+I+ N++ Y S + +L +N +I PG+ + G +G+GKS+ R D E
Sbjct: 1341 QGKIQIQNLSVRYDSSLK-PVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFE 1399
Query: 477 GMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGRE--DATMEDIVQAAKE 534
G + +DG DI L + LR ++ I+ Q+PVLFS TI N+ R+ D+T+ + ++ A+
Sbjct: 1400 GHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQL 1459
Query: 535 ANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESE 594
+ LP D ++ EGG S GQ+Q +ARA +R I ++D AT+++D +E
Sbjct: 1460 KLV---VKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATE 1516
Query: 595 AMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYF 651
++Q+V+ T++++AHR+ T+ +AD +I + G +E E+LL RK F
Sbjct: 1517 NILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDSVF 1573
>gi|134142345 ATP-binding cassette, sub-family C, member 1 isoform 3
[Homo sapiens]
Length = 1475
Score = 174 bits (440), Expect = 7e-43
Identities = 224/958 (23%), Positives = 393/958 (41%), Gaps = 156/958 (16%)
Query: 395 ETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALV 454
++I+R+P+ D + I N TF + +R + LN + I G + A+V
Sbjct: 628 DSIERRPVKDGGGTNS---------ITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVV 677
Query: 455 GPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAE 514
G G GKS+ L + D EG V + G + V Q+ + + ++ E
Sbjct: 678 GQVGCGKSSLLSALLAEMDKVEGHVAIKG-------------SVAYVPQQAWIQNDSLRE 724
Query: 515 NIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALI 574
NI + G Q+ + V A AL+
Sbjct: 725 NILF-------------------------------------GCQLEEPYYRSVIQACALL 747
Query: 575 RNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTA 634
+ +IL T E+ K T I V H +S + D II G
Sbjct: 748 PDLEILPSGDRT------------EIGEK-----TRILVTHSMSYLPQVDVIIVMSGGKI 790
Query: 635 VERGTHEELLERKGVY--FTLVTLQSQGNQALNEEDIKDATEDDMLARTFSRGSY-QDSL 691
E G+++ELL R G + F ++ Q E + + A+ G DS
Sbjct: 791 SEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSA 850
Query: 692 RASIRQRSKSQLSYLVHEPPLAVVDHKSTYE----EDRKDKDIPVQEEVEPAPVRRILKF 747
++++ S SY H ST E E +K++ + E + A ++ K
Sbjct: 851 GKQLQRQLSSSSSYSGDISR----HHNSTAELQKAEAKKEETWKLME-ADKAQTGQV-KL 904
Query: 748 SAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQILGTFS-----------IPDKEEQRSQIN 796
S W YM ++G ++ ++ F+ + + S I + ++ +++
Sbjct: 905 SV-YWDYMK--AIGLFIS--FLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVR 959
Query: 797 GVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGA 856
++ A+G F A + G L ++ L ++L +++F+ R G
Sbjct: 960 --LSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFE--RTPSGN 1015
Query: 857 LTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGA 916
L R + + V I M + S NV A I+ + +++I P L L
Sbjct: 1016 LVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIII----PPLGLIYF 1071
Query: 917 TQTRMLTGFASRDKQALEMVGQIT-----NEALSNIRTVAGIGKERRFIEALETELEKPF 971
R +SR + LE V + NE L + + ++ RFI + ++++
Sbjct: 1072 FVQRFYVA-SSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQ 1130
Query: 972 KTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATAL 1031
K + +C+ N + F+ +F VIS LSA +
Sbjct: 1131 KAYYPSIVANRWLAVRLECV----------------GNCIVLFAALFAVISRHSLSAGLV 1174
Query: 1032 GRAFSYT-------------PSYAKAKISAA---RFFQLLDRQPPISVYNTAGEKWDNFQ 1075
G + SY+ S + I A + + +++ P + TA
Sbjct: 1175 GLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQV 1234
Query: 1076 GKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQG 1135
G+++F + Y D VL ++V+I+ G+ + VG +G GKS+ L R + +G
Sbjct: 1235 GRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEG 1293
Query: 1136 KVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQA 1195
+++IDG + K+ + LR I I+ Q+PVLF+ S+ N+ D + E V + + A
Sbjct: 1294 EIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNL---DPFSQYSDEEVWTSLELA 1350
Query: 1196 QLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEK 1255
L DFV +LP+K + G LS G++Q + +ARA++R KIL+LDEAT+A+D E++
Sbjct: 1351 HLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDD 1410
Query: 1256 TVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKL 1313
+Q + E T + IAHRL+TI + + V+ +G + E G +L+ Q+G +Y +
Sbjct: 1411 LIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSM 1468
Score = 58.9 bits (141), Expect = 3e-08
Identities = 58/232 (25%), Positives = 92/232 (39%), Gaps = 70/232 (30%)
Query: 1085 FTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDS 1144
FT+ +R D LNG++ SI G +A VG GCGKS+ + L D +G V I G
Sbjct: 651 FTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG--- 706
Query: 1145 KKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSL 1204
++ V Q+ + S+ +NI +G +E VI A A L D + L
Sbjct: 707 ----------SVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQAC--ALLPDLEI-L 753
Query: 1205 PEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKA 1264
P T +G
Sbjct: 754 PSGDRTEIGE-------------------------------------------------- 763
Query: 1265 REGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVTT 1316
+T I++ H +S + D+I VM+ G + E G+++EL+A+ GA+ + + T
Sbjct: 764 ---KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRT 812
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.136 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,622,877
Number of Sequences: 37866
Number of extensions: 1790206
Number of successful extensions: 4664
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 80
Number of HSP's successfully gapped in prelim test: 15
Number of HSP's that attempted gapping in prelim test: 4021
Number of HSP's gapped (non-prelim): 333
length of query: 1321
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1207
effective length of database: 13,930,794
effective search space: 16814468358
effective search space used: 16814468358
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.