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Search of human proteins with 214010181
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|214010181 amyloid beta (A4) precursor-like protein 2 isoform
2 [Homo sapiens]
(751 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|214010181 amyloid beta (A4) precursor-like protein 2 isoform ... 1522 0.0
gi|4502147 amyloid beta (A4) precursor-like protein 2 isoform 1 ... 1513 0.0
gi|214010183 amyloid beta (A4) precursor-like protein 2 isoform ... 1205 0.0
gi|214010185 amyloid beta (A4) precursor-like protein 2 isoform ... 766 0.0
gi|41406055 amyloid beta A4 protein isoform b precursor [Homo sa... 757 0.0
gi|4502167 amyloid beta A4 protein isoform a precursor [Homo sap... 746 0.0
gi|209915573 amyloid beta A4 protein isoform f precursor [Homo s... 661 0.0
gi|41406057 amyloid beta A4 protein isoform c precursor [Homo sa... 638 0.0
gi|209915570 amyloid beta A4 protein isoform e precursor [Homo s... 553 e-157
gi|4885065 amyloid precursor-like protein 1 isoform 2 precursor ... 302 9e-82
gi|67782338 amyloid precursor-like protein 1 isoform 1 precursor... 301 1e-81
gi|10863909 serine protease inhibitor, Kunitz type, 2 [Homo sapi... 80 7e-15
gi|28212222 WFIKKN2 protein [Homo sapiens] 68 3e-11
gi|4502067 alpha-1-microglobulin/bikunin preproprotein [Homo sap... 64 7e-10
gi|189571689 serine protease inhibitor, Kunitz type, 3 [Homo sap... 64 7e-10
gi|74027265 serine peptidase inhibitor, Kunitz type 1 isoform 2 ... 62 1e-09
gi|4504329 serine peptidase inhibitor, Kunitz type 1 isoform 2 p... 62 1e-09
gi|32313599 serine peptidase inhibitor, Kunitz type 1 isoform 1 ... 62 1e-09
gi|31563528 serine peptidase inhibitor-like, with Kunitz and WAP... 62 2e-09
gi|10732863 serine peptidase inhibitor-like, with Kunitz and WAP... 62 2e-09
gi|73760409 tissue factor pathway inhibitor isoform b precursor ... 62 3e-09
gi|5454114 tissue factor pathway inhibitor isoform a precursor [... 62 3e-09
gi|145309328 papilin [Homo sapiens] 61 4e-09
gi|7662316 HIV-1 Vpr binding protein [Homo sapiens] 60 7e-09
gi|55743106 alpha 3 type VI collagen isoform 5 precursor [Homo s... 58 4e-08
gi|55743098 alpha 3 type VI collagen isoform 1 precursor [Homo s... 58 4e-08
gi|240255535 alpha 3 type VI collagen isoform 4 precursor [Homo ... 58 4e-08
gi|4503257 death-domain associated protein isoform a [Homo sapiens] 57 5e-08
gi|215422388 death-domain associated protein isoform a [Homo sap... 57 5e-08
gi|215422366 death-domain associated protein isoform b [Homo sap... 57 5e-08
>gi|214010181 amyloid beta (A4) precursor-like protein 2 isoform 2
[Homo sapiens]
Length = 751
Score = 1522 bits (3941), Expect = 0.0
Identities = 751/751 (100%), Positives = 751/751 (100%)
Query: 1 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN 60
MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN
Sbjct: 1 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN 60
Query: 61 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK 120
MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK
Sbjct: 61 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK 120
Query: 121 KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT 180
KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT
Sbjct: 121 KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT 180
Query: 181 LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEF 240
LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEF
Sbjct: 181 LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEF 240
Query: 241 PTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDK 300
PTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDK
Sbjct: 241 PTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDK 300
Query: 301 EITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVC 360
EITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVC
Sbjct: 301 EITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVC 360
Query: 361 KAMIPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAK 420
KAMIPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAK
Sbjct: 361 KAMIPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAK 420
Query: 421 NLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQ 480
NLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQ
Sbjct: 421 NLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQ 480
Query: 481 SDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERR 540
SDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERR
Sbjct: 481 SDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERR 540
Query: 541 NQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFH 600
NQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFH
Sbjct: 541 NQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFH 600
Query: 601 PFHPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVG 660
PFHPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVG
Sbjct: 601 PFHPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVG 660
Query: 661 GLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEVD 720
GLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEVD
Sbjct: 661 GLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEVD 720
Query: 721 PMLTPEERHLNKMQNHGYENPTYKYLEQMQI 751
PMLTPEERHLNKMQNHGYENPTYKYLEQMQI
Sbjct: 721 PMLTPEERHLNKMQNHGYENPTYKYLEQMQI 751
>gi|4502147 amyloid beta (A4) precursor-like protein 2 isoform 1
[Homo sapiens]
Length = 763
Score = 1513 bits (3918), Expect = 0.0
Identities = 751/763 (98%), Positives = 751/763 (98%), Gaps = 12/763 (1%)
Query: 1 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN 60
MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN
Sbjct: 1 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN 60
Query: 61 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK 120
MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK
Sbjct: 61 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK 120
Query: 121 KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT 180
KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT
Sbjct: 121 KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT 180
Query: 181 LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEF 240
LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEF
Sbjct: 181 LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEF 240
Query: 241 PTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDK 300
PTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDK
Sbjct: 241 PTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDK 300
Query: 301 EITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVC 360
EITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVC
Sbjct: 301 EITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVC 360
Query: 361 KAMIPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAK 420
KAMIPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAK
Sbjct: 361 KAMIPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAK 420
Query: 421 NLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQ 480
NLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQ
Sbjct: 421 NLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQ 480
Query: 481 SDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERR 540
SDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERR
Sbjct: 481 SDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERR 540
Query: 541 NQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFH 600
NQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFH
Sbjct: 541 NQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFH 600
Query: 601 PFHPFPALPENE------------GSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLD 648
PFHPFPALPENE GSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLD
Sbjct: 601 PFHPFPALPENEDTQPELYHPMKKGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLD 660
Query: 649 VKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQ 708
VKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQ
Sbjct: 661 VKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQ 720
Query: 709 YGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI 751
YGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI
Sbjct: 721 YGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI 763
>gi|214010183 amyloid beta (A4) precursor-like protein 2 isoform 3
[Homo sapiens]
Length = 695
Score = 1205 bits (3117), Expect = 0.0
Identities = 632/752 (84%), Positives = 645/752 (85%), Gaps = 58/752 (7%)
Query: 1 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN 60
MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN
Sbjct: 1 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN 60
Query: 61 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK 120
MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK
Sbjct: 61 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK 120
Query: 121 KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT 180
KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT
Sbjct: 121 KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT 180
Query: 181 LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEF 240
LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEE
Sbjct: 181 LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEE--------------------- 219
Query: 241 PTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDK 300
DE+EEE E+ ED D Y F + + E+ TE D D+
Sbjct: 220 -----------------DEEEEEEEDEEEDYDVYKSEFP-TEADLEDFTEAAVDEDDEDE 261
Query: 301 EITHDVKAVCSQEAMTGPCRAVMPR-WYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAV 359
E +V V R +Y+D KG G+ ++ V
Sbjct: 262 EEGEEV---------------VEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDV 306
Query: 360 CKAMIPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQA 419
+PPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQA
Sbjct: 307 ---KVPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQA 363
Query: 420 KNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAAL 479
KNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAAL
Sbjct: 364 KNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAAL 423
Query: 480 QSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEER 539
QSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEER
Sbjct: 424 QSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEER 483
Query: 540 RNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPF 599
RNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPF
Sbjct: 484 RNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPF 543
Query: 600 HPFHPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERV 659
HPFHPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERV
Sbjct: 544 HPFHPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERV 603
Query: 660 GGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEV 719
GGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEV
Sbjct: 604 GGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEV 663
Query: 720 DPMLTPEERHLNKMQNHGYENPTYKYLEQMQI 751
DPMLTPEERHLNKMQNHGYENPTYKYLEQMQI
Sbjct: 664 DPMLTPEERHLNKMQNHGYENPTYKYLEQMQI 695
>gi|214010185 amyloid beta (A4) precursor-like protein 2 isoform 4
[Homo sapiens]
Length = 522
Score = 766 bits (1978), Expect = 0.0
Identities = 388/391 (99%), Positives = 390/391 (99%)
Query: 361 KAMIPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAK 420
K ++PPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAK
Sbjct: 132 KCLVPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAK 191
Query: 421 NLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQ 480
NLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQ
Sbjct: 192 NLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQ 251
Query: 481 SDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERR 540
SDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERR
Sbjct: 252 SDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERR 311
Query: 541 NQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFH 600
NQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFH
Sbjct: 312 NQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFH 371
Query: 601 PFHPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVG 660
PFHPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVG
Sbjct: 372 PFHPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVG 431
Query: 661 GLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEVD 720
GLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEVD
Sbjct: 432 GLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEVD 491
Query: 721 PMLTPEERHLNKMQNHGYENPTYKYLEQMQI 751
PMLTPEERHLNKMQNHGYENPTYKYLEQMQI
Sbjct: 492 PMLTPEERHLNKMQNHGYENPTYKYLEQMQI 522
Score = 276 bits (706), Expect = 5e-74
Identities = 135/135 (100%), Positives = 135/135 (100%)
Query: 1 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN 60
MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN
Sbjct: 1 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN 60
Query: 61 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK 120
MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK
Sbjct: 61 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK 120
Query: 121 KQCKSRFVTPFKCLV 135
KQCKSRFVTPFKCLV
Sbjct: 121 KQCKSRFVTPFKCLV 135
>gi|41406055 amyloid beta A4 protein isoform b precursor [Homo
sapiens]
Length = 751
Score = 757 bits (1955), Expect = 0.0
Identities = 399/765 (52%), Positives = 521/765 (68%), Gaps = 48/765 (6%)
Query: 15 LLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDP 74
L LLLL TA AL + NAG +AEPQIAMFCG+LNMH+N+Q GKW+ DP
Sbjct: 5 LALLLLAAWTARALEVP-----TDGNAGL---LAEPQIAMFCGRLNMHMNVQNGKWDSDP 56
Query: 75 TGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKSR--FVTPFK 132
+GTK+C +TKE +LQYCQE+YPELQITNV+EANQ V+I NWC+R +KQCK+ FV P++
Sbjct: 57 SGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYR 116
Query: 133 CLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPCGV 192
CLVGEFVSD LLVP+KC+F H+ERM+VCE H HWHTV KE C + L+ YGMLLPCG+
Sbjct: 117 CLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGI 176
Query: 193 DQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDY-DVYKSEFPTEADLEDFTE 251
D+F G E+VCCP + +V + EED+ + + DY D + + A+ E+ E
Sbjct: 177 DKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAE 236
Query: 252 AAVDE--DDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAV 309
+E DDED+E+G+EV E+ + Y+ E T + T + + + V+ V
Sbjct: 237 VEEEEADDDEDDEDGDEVEEEAEEPYEEAT------ERTTSIATTTTTTTESVEEVVREV 290
Query: 310 CSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMIPPTPL 369
CS++A TGPCRA++ RWYFD+++GKC F YGGCGGNRNNF++E+YCMAVC + IP T
Sbjct: 291 CSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAIPTTAA 350
Query: 370 PTND-VDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQ 428
T D VD Y ET D+NEHA FQKAKE+LE +HR RM +V +EWEEAE QAKNLPKA+++
Sbjct: 351 STPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKK 410
Query: 429 TLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDPPRPHR 488
+IQHFQ V++LE+EAA+E+QQLVETH+ARVEAMLNDRRR+ALENY+ ALQ+ PPRP
Sbjct: 411 AVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRH 470
Query: 489 ILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLSLLY 548
+ L++YVRAE KDR HT++H++HV VDP+KAAQ++SQVMTHL VI ER NQSLSLLY
Sbjct: 471 VFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLY 530
Query: 549 KVPYVAQEIQEEIDELLQEQR-------ADM----------DQFTASISETPVDVR---V 588
VP VA+EIQ+E+DELLQ+++ A+M D S++ET V V
Sbjct: 531 NVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPV 590
Query: 589 SSEES-EEIPPFHPF--HPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDE 645
+ E S +++ P+H F PA ENE V + A+ + N+ +E
Sbjct: 591 NGEFSLDDLQPWHSFGADSVPANTENEVEPVDARP----AADRGLTTRPGSGLTNIKTEE 646
Query: 646 TLDVKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLR 705
+VK M G E + + ED + A+IGL+V V IATVIVI+LVML+
Sbjct: 647 ISEVK-MDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLK 705
Query: 706 KRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQ 750
K+QY +I HG+VEVD +TPEERHL+KMQ +GYENPTYK+ EQMQ
Sbjct: 706 KKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQ 750
>gi|4502167 amyloid beta A4 protein isoform a precursor [Homo
sapiens]
Length = 770
Score = 746 bits (1925), Expect = 0.0
Identities = 398/784 (50%), Positives = 522/784 (66%), Gaps = 67/784 (8%)
Query: 15 LLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDP 74
L LLLL TA AL + NAG +AEPQIAMFCG+LNMH+N+Q GKW+ DP
Sbjct: 5 LALLLLAAWTARALEVP-----TDGNAGL---LAEPQIAMFCGRLNMHMNVQNGKWDSDP 56
Query: 75 TGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKSR--FVTPFK 132
+GTK+C +TKE +LQYCQE+YPELQITNV+EANQ V+I NWC+R +KQCK+ FV P++
Sbjct: 57 SGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYR 116
Query: 133 CLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPCGV 192
CLVGEFVSD LLVP+KC+F H+ERM+VCE H HWHTV KE C + L+ YGMLLPCG+
Sbjct: 117 CLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGI 176
Query: 193 DQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDY-DVYKSEFPTEADLEDFTE 251
D+F G E+VCCP + +V + EED+ + + DY D + + A+ E+ E
Sbjct: 177 DKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAE 236
Query: 252 AAVDE--DDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAV 309
+E DDED+E+G+EV E+ + Y+ E T + T + + + V+ V
Sbjct: 237 VEEEEADDDEDDEDGDEVEEEAEEPYEEAT------ERTTSIATTTTTTTESVEEVVREV 290
Query: 310 CSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMIP---- 365
CS++A TGPCRA++ RWYFD+++GKC F YGGCGGNRNNF++E+YCMAVC + +
Sbjct: 291 CSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLL 350
Query: 366 ----------PTPLPT------NDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVK 409
P LPT + VD Y ET D+NEHA FQKAKE+LE +HR RM +V
Sbjct: 351 KTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVM 410
Query: 410 KEWEEAELQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRR 469
+EWEEAE QAKNLPKA+++ +IQHFQ V++LE+EAA+E+QQLVETH+ARVEAMLNDRRR
Sbjct: 411 REWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRR 470
Query: 470 MALENYLAALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQV 529
+ALENY+ ALQ+ PPRP + L++YVRAE KDR HT++H++HV VDP+KAAQ++SQV
Sbjct: 471 LALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQV 530
Query: 530 MTHLHVIEERRNQSLSLLYKVPYVAQEIQEEIDELLQEQR-------ADM---------- 572
MTHL VI ER NQSLSLLY VP VA+EIQ+E+DELLQ+++ A+M
Sbjct: 531 MTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGN 590
Query: 573 DQFTASISETPVDVR---VSSEES-EEIPPFHPF--HPFPALPENEGSGVGEQDGGLIGA 626
D S++ET V V+ E S +++ P+H F PA ENE V + A
Sbjct: 591 DALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARP----AA 646
Query: 627 EEKVINSKNKVDENMVIDETLDVKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGL 686
+ + N+ +E +VK M G E + + ED + A+IGL
Sbjct: 647 DRGLTTRPGSGLTNIKTEEISEVK-MDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGL 705
Query: 687 LVIAVAIATVIVISLVMLRKRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYL 746
+V V IATVIVI+LVML+K+QY +I HG+VEVD +TPEERHL+KMQ +GYENPTYK+
Sbjct: 706 MVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFF 765
Query: 747 EQMQ 750
EQMQ
Sbjct: 766 EQMQ 769
>gi|209915573 amyloid beta A4 protein isoform f precursor [Homo
sapiens]
Length = 714
Score = 661 bits (1705), Expect = 0.0
Identities = 353/706 (50%), Positives = 467/706 (66%), Gaps = 59/706 (8%)
Query: 93 EMYPELQITNVMEANQRVSIDNWCRRDKKQCKSR--FVTPFKCLVGEFVSDVLLVPEKCQ 150
E+YPELQITNV+EANQ V+I NWC+R +KQCK+ FV P++CLVGEFVSD LLVP+KC+
Sbjct: 19 EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCK 78
Query: 151 FFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPCGVDQFHGTEYVCCPQTKIIG 210
F H+ERM+VCE H HWHTV KE C + L+ YGMLLPCG+D+F G E+VCCP +
Sbjct: 79 FLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESD 138
Query: 211 SVSKEEEEEDEEEEEEEDEEEDY-DVYKSEFPTEADLEDFTEAAVDE--DDEDEEEGEEV 267
+V + EED+ + + DY D + + A+ E+ E +E DDED+E+G+EV
Sbjct: 139 NVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEV 198
Query: 268 VEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAVCSQEAMTGPCRAVMPRWY 327
E+ + Y+ E T + T + + + V+ VCS++A TGPCRA++ RWY
Sbjct: 199 EEEAEEPYEEAT------ERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWY 252
Query: 328 FDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMIP--------------PTPLPT-- 371
FD+++GKC F YGGCGGNRNNF++E+YCMAVC + + P LPT
Sbjct: 253 FDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTA 312
Query: 372 ----NDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAER 427
+ VD Y ET D+NEHA FQKAKE+LE +HR RM +V +EWEEAE QAKNLPKA++
Sbjct: 313 ASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADK 372
Query: 428 QTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDPPRPH 487
+ +IQHFQ V++LE+EAA+E+QQLVETH+ARVEAMLNDRRR+ALENY+ ALQ+ PPRP
Sbjct: 373 KAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPR 432
Query: 488 RILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLSLL 547
+ L++YVRAE KDR HT++H++HV VDP+KAAQ++SQVMTHL VI ER NQSLSLL
Sbjct: 433 HVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLL 492
Query: 548 YKVPYVAQEIQEEIDELLQEQR-------ADM----------DQFTASISETPVDVR--- 587
Y VP VA+EIQ+E+DELLQ+++ A+M D S++ET V
Sbjct: 493 YNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLP 552
Query: 588 VSSEES-EEIPPFHPF--HPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVID 644
V+ E S +++ P+H F PA ENE V + A+ + N+ +
Sbjct: 553 VNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARP----AADRGLTTRPGSGLTNIKTE 608
Query: 645 ETLDVKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVML 704
E +VK M G E + + ED + A+IGL+V V IATVIVI+LVML
Sbjct: 609 EISEVK-MDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVML 667
Query: 705 RKRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQ 750
+K+QY +I HG+VEVD +TPEERHL+KMQ +GYENPTYK+ EQMQ
Sbjct: 668 KKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQ 713
>gi|41406057 amyloid beta A4 protein isoform c precursor [Homo
sapiens]
Length = 695
Score = 638 bits (1646), Expect = 0.0
Identities = 367/762 (48%), Positives = 468/762 (61%), Gaps = 98/762 (12%)
Query: 15 LLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDP 74
L LLLL TA AL + NAG +AEPQIAMFCG+LNMH+N+Q GKW+ DP
Sbjct: 5 LALLLLAAWTARALEVP-----TDGNAGL---LAEPQIAMFCGRLNMHMNVQNGKWDSDP 56
Query: 75 TGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKSR--FVTPFK 132
+GTK+C +TKE +LQYCQE+YPELQITNV+EANQ V+I NWC+R +KQCK+ FV P++
Sbjct: 57 SGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYR 116
Query: 133 CLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPCGV 192
CLVGEFVSD LLVP+KC+F H+ERM+VCE H HWHTV KE C + L+ YGMLLPCG+
Sbjct: 117 CLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGI 176
Query: 193 DQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEA 252
D+F G E+VCCP EE + + + EE+D DV+ T D D +E
Sbjct: 177 DKFRGVEFVCCPLA-----------EESDNVDSADAEEDDSDVWWGGADT--DYADGSED 223
Query: 253 AVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAVCSQ 312
V E E+EE E E+ D D GD+ EE EP + T I
Sbjct: 224 KVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEE-AEEPYEEATERTTSIATTTTTTTE- 281
Query: 313 EAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMIPPTPLPTN 372
S + VR +P T T
Sbjct: 282 ------------------SVEEVVR--------------------------VPTTAASTP 297
Query: 373 D-VDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLI 431
D VD Y ET D+NEHA FQKAKE+LE +HR RM +V +EWEEAE QAKNLPKA+++ +I
Sbjct: 298 DAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVI 357
Query: 432 QHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDPPRPHRILQ 491
QHFQ V++LE+EAA+E+QQLVETH+ARVEAMLNDRRR+ALENY+ ALQ+ PPRP +
Sbjct: 358 QHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFN 417
Query: 492 ALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLSLLYKVP 551
L++YVRAE KDR HT++H++HV VDP+KAAQ++SQVMTHL VI ER NQSLSLLY VP
Sbjct: 418 MLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVP 477
Query: 552 YVAQEIQEEIDELLQEQR-------ADM----------DQFTASISETPVDVR---VSSE 591
VA+EIQ+E+DELLQ+++ A+M D S++ET V V+ E
Sbjct: 478 AVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGE 537
Query: 592 ES-EEIPPFHPF--HPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLD 648
S +++ P+H F PA ENE V + A+ + N+ +E +
Sbjct: 538 FSLDDLQPWHSFGADSVPANTENEVEPVDARP----AADRGLTTRPGSGLTNIKTEEISE 593
Query: 649 VKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQ 708
VK M G E + + ED + A+IGL+V V IATVIVI+LVML+K+Q
Sbjct: 594 VK-MDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQ 652
Query: 709 YGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQ 750
Y +I HG+VEVD +TPEERHL+KMQ +GYENPTYK+ EQMQ
Sbjct: 653 YTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQ 694
>gi|209915570 amyloid beta A4 protein isoform e precursor [Homo
sapiens]
Length = 639
Score = 553 bits (1426), Expect = e-157
Identities = 322/684 (47%), Positives = 413/684 (60%), Gaps = 90/684 (13%)
Query: 93 EMYPELQITNVMEANQRVSIDNWCRRDKKQCKSR--FVTPFKCLVGEFVSDVLLVPEKCQ 150
E+YPELQITNV+EANQ V+I NWC+R +KQCK+ FV P++CLVGEFVSD LLVP+KC+
Sbjct: 19 EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCK 78
Query: 151 FFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPCGVDQFHGTEYVCCPQTKIIG 210
F H+ERM+VCE H HWHTV KE C + L+ YGMLLPCG+D+F G E+VCCP
Sbjct: 79 FLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLA---- 134
Query: 211 SVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVED 270
EE + + + EE+D DV+ T D D +E V E E+EE E E+
Sbjct: 135 -------EESDNVDSADAEEDDSDVWWGGADT--DYADGSEDKVVEVAEEEEVAEVEEEE 185
Query: 271 RDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAVCSQEAMTGPCRAVMPRWYFDL 330
D D GD+ EE EP + T I
Sbjct: 186 ADDDEDDEDGDEVEEE-AEEPYEEATERTTSIATTTTTTTE------------------- 225
Query: 331 SKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMIPPTPLPTND-VDVYFETSADDNEHAR 389
S + VR +P T T D VD Y ET D+NEHA
Sbjct: 226 SVEEVVR--------------------------VPTTAASTPDAVDKYLETPGDENEHAH 259
Query: 390 FQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQHFQAMVKALEKEAASEK 449
FQKAKE+LE +HR RM +V +EWEEAE QAKNLPKA+++ +IQHFQ V++LE+EAA+E+
Sbjct: 260 FQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANER 319
Query: 450 QQLVETHLARVEAMLNDRRRMALENYLAALQSDPPRPHRILQALRRYVRAENKDRLHTIR 509
QQLVETH+ARVEAMLNDRRR+ALENY+ ALQ+ PPRP + L++YVRAE KDR HT++
Sbjct: 320 QQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLK 379
Query: 510 HYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLSLLYKVPYVAQEIQEEIDELLQEQR 569
H++HV VDP+KAAQ++SQVMTHL VI ER NQSLSLLY VP VA+EIQ+E+DELLQ+++
Sbjct: 380 HFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQ 439
Query: 570 -------ADM----------DQFTASISETPVDVR---VSSEES-EEIPPFHPF--HPFP 606
A+M D S++ET V V+ E S +++ P+H F P
Sbjct: 440 NYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVP 499
Query: 607 ALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVGGLEEER 666
A ENE V + A+ + N+ +E +VK M G E
Sbjct: 500 ANTENEVEPVDARP----AADRGLTTRPGSGLTNIKTEEISEVK-MDAEFRHDSGYEVHH 554
Query: 667 ESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEVDPMLTPE 726
+ + ED + A+IGL+V V IATVIVI+LVML+K+QY +I HG+VEVD +TPE
Sbjct: 555 QKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPE 614
Query: 727 ERHLNKMQNHGYENPTYKYLEQMQ 750
ERHL+KMQ +GYENPTYK+ EQMQ
Sbjct: 615 ERHLSKMQQNGYENPTYKFFEQMQ 638
>gi|4885065 amyloid precursor-like protein 1 isoform 2 precursor
[Homo sapiens]
Length = 650
Score = 302 bits (773), Expect = 9e-82
Identities = 170/386 (44%), Positives = 239/386 (61%), Gaps = 22/386 (5%)
Query: 364 IPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLP 423
+ PTP PT+ VD+YF + +EH F +AK LE R +++ V +EW A+ Q+KNLP
Sbjct: 284 VTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLP 343
Query: 424 KAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDP 483
KA+RQ L +HFQ++++ LE++ + E+Q+LVETH RV A++ND+RR ALE +LAALQ+DP
Sbjct: 344 KADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADP 403
Query: 484 PRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQS 543
P+ R+L ALRRY+RAE K++ HT+RHYQHV AVDPEKA QM+ QV THL VIEER NQS
Sbjct: 404 PQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQS 463
Query: 544 LSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFHPFH 603
L LL + P++AQE++ +I ELL + + E P S ++ PP
Sbjct: 464 LGLLDQNPHLAQELRPQIQELLHSEHLGPSEL-----EAPAPGGSSEDKGGLQPPDSKDD 518
Query: 604 PFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVGGLE 663
LP+ G EQD S K N + V + E
Sbjct: 519 TPMTLPK----GSTEQDAA----------SPEKEKMNPLEQYERKVNASVPRGFPFHSSE 564
Query: 664 EERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVML-RKRQYGTISHGIVEVDPM 722
+R+ + P +S A+ GLL++ ++IV+S+++L RK+ YG ISHG+VEVDPM
Sbjct: 565 IQRDELAP--AGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVEVDPM 622
Query: 723 LTPEERHLNKMQNHGYENPTYKYLEQ 748
LT EE+ L ++Q HGYENPTY++LE+
Sbjct: 623 LTLEEQQLRELQRHGYENPTYRFLEE 648
Score = 188 bits (478), Expect = 1e-47
Identities = 104/257 (40%), Positives = 143/257 (55%), Gaps = 23/257 (8%)
Query: 15 LLLLLLVGLTAPAL-ALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPD 73
L LLLL+ PA+ +LAG + G A Q+A CG+L +H +++TG+WEPD
Sbjct: 24 LPLLLLLLRAQPAIGSLAG------GSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPD 77
Query: 74 PTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKK-QCKSRF--VTP 130
P ++ C + VL+YC++MYPELQI V +A Q + ++ WC + C V P
Sbjct: 78 PQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVP 137
Query: 131 FKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPC 190
F+CL GEFVS+ LLVPE C+F H+ERM+ CE+ H +EAC +QG+ L+ GMLLPC
Sbjct: 138 FRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPC 197
Query: 191 GVDQFHGTEYVCC-------PQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTE 243
G D+F G EYVCC P +G S E EDEEE+ FP
Sbjct: 198 GSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEE-----ESFPQP 252
Query: 244 ADLEDFTEAAVDEDDED 260
D + F E E++E+
Sbjct: 253 VD-DYFVEPPQAEEEEE 268
>gi|67782338 amyloid precursor-like protein 1 isoform 1 precursor
[Homo sapiens]
Length = 651
Score = 301 bits (771), Expect = 1e-81
Identities = 170/386 (44%), Positives = 238/386 (61%), Gaps = 21/386 (5%)
Query: 364 IPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLP 423
+ PTP PT+ VD+YF + +EH F +AK LE R +++ V +EW A+ Q+KNLP
Sbjct: 284 VTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLP 343
Query: 424 KAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDP 483
KA+RQ L +HFQ++++ LE++ + E+Q+LVETH RV A++ND+RR ALE +LAALQ+DP
Sbjct: 344 KADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADP 403
Query: 484 PRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQS 543
P+ R+L ALRRY+RAE K++ HT+RHYQHV AVDPEKA QM+ QV THL VIEER NQS
Sbjct: 404 PQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQS 463
Query: 544 LSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFHPFH 603
L LL + P++AQE++ +I ELL + + A SSE+ + P P
Sbjct: 464 LGLLDQNPHLAQELRPQIQELLHSEHLGPSELEAPAPGG------SSEDKGGLQP--PDS 515
Query: 604 PFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVGGLE 663
P G EQD S K N + V + E
Sbjct: 516 KDADTPMTLPKGSTEQDAA----------SPEKEKMNPLEQYERKVNASVPRGFPFHSSE 565
Query: 664 EERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVML-RKRQYGTISHGIVEVDPM 722
+R+ + P +S A+ GLL++ ++IV+S+++L RK+ YG ISHG+VEVDPM
Sbjct: 566 IQRDELAP--AGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVEVDPM 623
Query: 723 LTPEERHLNKMQNHGYENPTYKYLEQ 748
LT EE+ L ++Q HGYENPTY++LE+
Sbjct: 624 LTLEEQQLRELQRHGYENPTYRFLEE 649
Score = 188 bits (478), Expect = 1e-47
Identities = 104/257 (40%), Positives = 143/257 (55%), Gaps = 23/257 (8%)
Query: 15 LLLLLLVGLTAPAL-ALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPD 73
L LLLL+ PA+ +LAG + G A Q+A CG+L +H +++TG+WEPD
Sbjct: 24 LPLLLLLLRAQPAIGSLAG------GSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPD 77
Query: 74 PTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKK-QCKSRF--VTP 130
P ++ C + VL+YC++MYPELQI V +A Q + ++ WC + C V P
Sbjct: 78 PQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVP 137
Query: 131 FKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPC 190
F+CL GEFVS+ LLVPE C+F H+ERM+ CE+ H +EAC +QG+ L+ GMLLPC
Sbjct: 138 FRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPC 197
Query: 191 GVDQFHGTEYVCC-------PQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTE 243
G D+F G EYVCC P +G S E EDEEE+ FP
Sbjct: 198 GSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEE-----ESFPQP 252
Query: 244 ADLEDFTEAAVDEDDED 260
D + F E E++E+
Sbjct: 253 VD-DYFVEPPQAEEEEE 268
>gi|10863909 serine protease inhibitor, Kunitz type, 2 [Homo
sapiens]
Length = 252
Score = 80.1 bits (196), Expect = 7e-15
Identities = 34/83 (40%), Positives = 46/83 (55%)
Query: 288 PTEPGSDGTMSDKEITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNR 347
P+ P + + + C+ A+TGPCRA PRWYFD+ + C FIYGGC GN+
Sbjct: 111 PSAPRRQDSEDHSSDMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNK 170
Query: 348 NNFESEDYCMAVCKAMIPPTPLP 370
N++ SE+ CM C PLP
Sbjct: 171 NSYRSEEACMLRCFRQQENPPLP 193
Score = 62.0 bits (149), Expect = 2e-09
Identities = 22/51 (43%), Positives = 34/51 (66%)
Query: 310 CSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVC 360
C + G CRA MPRW+++++ G C F+YGGC GN NN+ +++ C+ C
Sbjct: 38 CLVSKVVGRCRASMPRWWYNVTDGSCQLFVYGGCDGNSNNYLTKEECLKKC 88
>gi|28212222 WFIKKN2 protein [Homo sapiens]
Length = 576
Score = 68.2 bits (165), Expect = 3e-11
Identities = 27/53 (50%), Positives = 34/53 (64%)
Query: 308 AVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVC 360
A CS A+ GPC+A PRW ++ G+C F+YGGC GN NNFES + C C
Sbjct: 384 AACSLPALQGPCKAYAPRWAYNSQTGQCQSFVYGGCEGNGNNFESREACEESC 436
Score = 44.3 bits (103), Expect = 4e-04
Identities = 18/53 (33%), Positives = 26/53 (49%)
Query: 308 AVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVC 360
A C + + C RW+FD C+ F +G C N N+FE+ + CM C
Sbjct: 326 AECLKPPDSEDCGEEQTRWHFDAQANNCLTFTFGHCHRNLNHFETYEACMLAC 378
>gi|4502067 alpha-1-microglobulin/bikunin preproprotein [Homo
sapiens]
Length = 352
Score = 63.5 bits (153), Expect = 7e-10
Identities = 28/53 (52%), Positives = 31/53 (58%)
Query: 308 AVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVC 360
A C+ + GPCRA + W FD KGKCV F YGGC GN N F SE C C
Sbjct: 285 AACNLPIVRGPCRAFIQLWAFDAVKGKCVLFPYGGCQGNGNKFYSEKECREYC 337
Score = 51.6 bits (122), Expect = 3e-06
Identities = 25/74 (33%), Positives = 37/74 (50%), Gaps = 1/74 (1%)
Query: 290 EPGSDGTMSDKEITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNN 349
E GS G E+T + C GPC + R++++ + C F YGGC GN NN
Sbjct: 212 EEGSGGGQLVTEVTKKEDS-CQLGYSAGPCMGMTSRYFYNGTSMACETFQYGGCMGNGNN 270
Query: 350 FESEDYCMAVCKAM 363
F +E C+ C+ +
Sbjct: 271 FVTEKECLQTCRTV 284
>gi|189571689 serine protease inhibitor, Kunitz type, 3 [Homo
sapiens]
Length = 89
Score = 63.5 bits (153), Expect = 7e-10
Identities = 25/53 (47%), Positives = 32/53 (60%)
Query: 309 VCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCK 361
VC+ GPC+ M RW+F+ G+C F YGGCGGN NNF ++ C CK
Sbjct: 35 VCAFPMEKGPCQTYMTRWFFNFETGECELFAYGGCGGNSNNFLRKEKCEKFCK 87
>gi|74027265 serine peptidase inhibitor, Kunitz type 1 isoform 2
precursor [Homo sapiens]
Length = 513
Score = 62.4 bits (150), Expect = 1e-09
Identities = 25/57 (43%), Positives = 33/57 (57%)
Query: 307 KAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAM 363
K C TG C+ +PRWY++ C RF YGGC GN+NNFE E C+ C+ +
Sbjct: 372 KGHCVDLPDTGLCKESIPRWYYNPFSEHCARFTYGGCYGNKNNFEEEQQCLESCRGI 428
Score = 61.6 bits (148), Expect = 3e-09
Identities = 36/118 (30%), Positives = 58/118 (49%), Gaps = 6/118 (5%)
Query: 250 TEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAV 309
T+ V+ D ++ E + E + T D+ E+ T + +S K+ T D
Sbjct: 196 TDVRVERKDPNQVELWGLKEGTYLFQLTVTSSDHPED--TANVTVTVLSTKQ-TEDY--- 249
Query: 310 CSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMIPPT 367
C G CR PRWY+D ++ C F+YGGC GN+NN+ E+ C+ C+ + P+
Sbjct: 250 CLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKNNYLREEECILACRGVQGPS 307
>gi|4504329 serine peptidase inhibitor, Kunitz type 1 isoform 2
precursor [Homo sapiens]
Length = 513
Score = 62.4 bits (150), Expect = 1e-09
Identities = 25/57 (43%), Positives = 33/57 (57%)
Query: 307 KAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAM 363
K C TG C+ +PRWY++ C RF YGGC GN+NNFE E C+ C+ +
Sbjct: 372 KGHCVDLPDTGLCKESIPRWYYNPFSEHCARFTYGGCYGNKNNFEEEQQCLESCRGI 428
Score = 61.6 bits (148), Expect = 3e-09
Identities = 36/118 (30%), Positives = 58/118 (49%), Gaps = 6/118 (5%)
Query: 250 TEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAV 309
T+ V+ D ++ E + E + T D+ E+ T + +S K+ T D
Sbjct: 196 TDVRVERKDPNQVELWGLKEGTYLFQLTVTSSDHPED--TANVTVTVLSTKQ-TEDY--- 249
Query: 310 CSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMIPPT 367
C G CR PRWY+D ++ C F+YGGC GN+NN+ E+ C+ C+ + P+
Sbjct: 250 CLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKNNYLREEECILACRGVQGPS 307
>gi|32313599 serine peptidase inhibitor, Kunitz type 1 isoform 1
precursor [Homo sapiens]
Length = 529
Score = 62.4 bits (150), Expect = 1e-09
Identities = 25/57 (43%), Positives = 33/57 (57%)
Query: 307 KAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAM 363
K C TG C+ +PRWY++ C RF YGGC GN+NNFE E C+ C+ +
Sbjct: 388 KGHCVDLPDTGLCKESIPRWYYNPFSEHCARFTYGGCYGNKNNFEEEQQCLESCRGI 444
Score = 60.5 bits (145), Expect = 6e-09
Identities = 35/114 (30%), Positives = 56/114 (49%), Gaps = 6/114 (5%)
Query: 250 TEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAV 309
T+ V+ D ++ E + E + T D+ E+ T + +S K+ T D
Sbjct: 196 TDVRVERKDPNQVELWGLKEGTYLFQLTVTSSDHPED--TANVTVTVLSTKQ-TEDY--- 249
Query: 310 CSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAM 363
C G CR PRWY+D ++ C F+YGGC GN+NN+ E+ C+ C+ +
Sbjct: 250 CLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKNNYLREEECILACRGV 303
>gi|31563528 serine peptidase inhibitor-like, with Kunitz and WAP
domains 1 isoform 2 [Homo sapiens]
Length = 117
Score = 62.0 bits (149), Expect = 2e-09
Identities = 24/53 (45%), Positives = 30/53 (56%)
Query: 309 VCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCK 361
VC TGPC A W++D C F+YGGC GN NNF+S+ C+ CK
Sbjct: 60 VCEMPKETGPCLAYFLHWWYDKKDNTCSMFVYGGCQGNNNNFQSKANCLNTCK 112
>gi|10732863 serine peptidase inhibitor-like, with Kunitz and WAP
domains 1 isoform 1 precursor [Homo sapiens]
Length = 133
Score = 62.0 bits (149), Expect = 2e-09
Identities = 24/53 (45%), Positives = 30/53 (56%)
Query: 309 VCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCK 361
VC TGPC A W++D C F+YGGC GN NNF+S+ C+ CK
Sbjct: 76 VCEMPKETGPCLAYFLHWWYDKKDNTCSMFVYGGCQGNNNNFQSKANCLNTCK 128
>gi|73760409 tissue factor pathway inhibitor isoform b precursor
[Homo sapiens]
Length = 251
Score = 61.6 bits (148), Expect = 3e-09
Identities = 24/51 (47%), Positives = 36/51 (70%)
Query: 310 CSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVC 360
C+ +A GPC+A+M R++F++ +C FIYGGC GN+N FES + C +C
Sbjct: 54 CAFKADDGPCKAIMKRFFFNIFTRQCEEFIYGGCEGNQNRFESLEECKKMC 104
Score = 50.8 bits (120), Expect = 5e-06
Identities = 21/52 (40%), Positives = 31/52 (59%)
Query: 310 CSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCK 361
C E G CR + R++++ +C RF YGGC GN NNFE+ + C +C+
Sbjct: 125 CFLEEDPGICRGYITRYFYNNQTKQCERFKYGGCLGNMNNFETLEECKNICE 176
>gi|5454114 tissue factor pathway inhibitor isoform a precursor
[Homo sapiens]
Length = 304
Score = 61.6 bits (148), Expect = 3e-09
Identities = 24/51 (47%), Positives = 36/51 (70%)
Query: 310 CSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVC 360
C+ +A GPC+A+M R++F++ +C FIYGGC GN+N FES + C +C
Sbjct: 54 CAFKADDGPCKAIMKRFFFNIFTRQCEEFIYGGCEGNQNRFESLEECKKMC 104
Score = 55.1 bits (131), Expect = 2e-07
Identities = 25/52 (48%), Positives = 30/52 (57%)
Query: 310 CSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCK 361
C A G CRA R+Y++ GKC F Y GCGGN NNF S+ C+ CK
Sbjct: 217 CLTPADRGLCRANENRFYYNSVIGKCRPFKYSGCGGNENNFTSKQECLRACK 268
Score = 50.8 bits (120), Expect = 5e-06
Identities = 21/52 (40%), Positives = 31/52 (59%)
Query: 310 CSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCK 361
C E G CR + R++++ +C RF YGGC GN NNFE+ + C +C+
Sbjct: 125 CFLEEDPGICRGYITRYFYNNQTKQCERFKYGGCLGNMNNFETLEECKNICE 176
>gi|145309328 papilin [Homo sapiens]
Length = 1251
Score = 60.8 bits (146), Expect = 4e-09
Identities = 30/70 (42%), Positives = 36/70 (51%), Gaps = 2/70 (2%)
Query: 303 THDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKA 362
+H C + G C RWYF S G+C RF YGGC GN NNF SE CM+ C+
Sbjct: 720 SHAYPVRCLLPSAHGSCADWAARWYFVASVGQCNRFWYGGCHGNANNFASEQECMSSCQG 779
Query: 363 MI--PPTPLP 370
+ P P P
Sbjct: 780 SLHGPRRPQP 789
>gi|7662316 HIV-1 Vpr binding protein [Homo sapiens]
Length = 1507
Score = 60.1 bits (144), Expect = 7e-09
Identities = 33/95 (34%), Positives = 50/95 (52%), Gaps = 7/95 (7%)
Query: 215 EEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYY 274
E+EEED+EEEE+E+E++D D ++ E D + EA ++EDD +E GE+ D
Sbjct: 1398 EDEEEDQEEEEQEEEDDDEDDDDTDDLDELDTDQLLEAELEEDDNNENAGEDGDND---- 1453
Query: 275 YDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAV 309
F D N E G DG D + +V+ +
Sbjct: 1454 ---FSPSDEELANLLEEGEDGEDEDSDADEEVELI 1485
Score = 35.0 bits (79), Expect = 0.26
Identities = 25/98 (25%), Positives = 46/98 (46%), Gaps = 28/98 (28%)
Query: 212 VSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVE-- 269
V ++ EDE+EEE+++EEE E+++D+E+ ++ +
Sbjct: 1389 VGRQRLAEDEDEEEDQEEEEQ-----------------------EEEDDDEDDDDTDDLD 1425
Query: 270 --DRDYYYDTFKGDDYNEENPTEPG-SDGTMSDKEITH 304
D D + +D N EN E G +D + SD+E+ +
Sbjct: 1426 ELDTDQLLEAELEEDDNNENAGEDGDNDFSPSDEELAN 1463
>gi|55743106 alpha 3 type VI collagen isoform 5 precursor [Homo
sapiens]
Length = 2971
Score = 57.8 bits (138), Expect = 4e-08
Identities = 23/56 (41%), Positives = 31/56 (55%)
Query: 309 VCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMI 364
+C G CR + +WY+D + C RF YGGCGGN N F S+ C VC ++
Sbjct: 2905 ICKLPKDEGTCRDFILKWYYDPNTKSCARFWYGGCGGNENKFGSQKECEKVCAPVL 2960
>gi|55743098 alpha 3 type VI collagen isoform 1 precursor [Homo
sapiens]
Length = 3177
Score = 57.8 bits (138), Expect = 4e-08
Identities = 23/56 (41%), Positives = 31/56 (55%)
Query: 309 VCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMI 364
+C G CR + +WY+D + C RF YGGCGGN N F S+ C VC ++
Sbjct: 3111 ICKLPKDEGTCRDFILKWYYDPNTKSCARFWYGGCGGNENKFGSQKECEKVCAPVL 3166
>gi|240255535 alpha 3 type VI collagen isoform 4 precursor [Homo
sapiens]
Length = 2570
Score = 57.8 bits (138), Expect = 4e-08
Identities = 23/56 (41%), Positives = 31/56 (55%)
Query: 309 VCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMI 364
+C G CR + +WY+D + C RF YGGCGGN N F S+ C VC ++
Sbjct: 2504 ICKLPKDEGTCRDFILKWYYDPNTKSCARFWYGGCGGNENKFGSQKECEKVCAPVL 2559
>gi|4503257 death-domain associated protein isoform a [Homo sapiens]
Length = 740
Score = 57.4 bits (137), Expect = 5e-08
Identities = 36/99 (36%), Positives = 47/99 (47%), Gaps = 5/99 (5%)
Query: 203 CPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEE 262
CP + +++EE DEEEEEEE+EEE+ E E DLE E EDDE+E+
Sbjct: 427 CPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEE---EEDLEQMQEG--QEDDEEED 481
Query: 263 EGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKE 301
E EE +D + E EPG + S E
Sbjct: 482 EEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGE 520
>gi|215422388 death-domain associated protein isoform a [Homo
sapiens]
Length = 740
Score = 57.4 bits (137), Expect = 5e-08
Identities = 36/99 (36%), Positives = 47/99 (47%), Gaps = 5/99 (5%)
Query: 203 CPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEE 262
CP + +++EE DEEEEEEE+EEE+ E E DLE E EDDE+E+
Sbjct: 427 CPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEE---EEDLEQMQEG--QEDDEEED 481
Query: 263 EGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKE 301
E EE +D + E EPG + S E
Sbjct: 482 EEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGE 520
>gi|215422366 death-domain associated protein isoform b [Homo
sapiens]
Length = 752
Score = 57.4 bits (137), Expect = 5e-08
Identities = 36/99 (36%), Positives = 47/99 (47%), Gaps = 5/99 (5%)
Query: 203 CPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEE 262
CP + +++EE DEEEEEEE+EEE+ E E DLE E EDDE+E+
Sbjct: 439 CPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEE---EEDLEQMQEG--QEDDEEED 493
Query: 263 EGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKE 301
E EE +D + E EPG + S E
Sbjct: 494 EEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGE 532
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,541,141
Number of Sequences: 37866
Number of extensions: 1547870
Number of successful extensions: 34527
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 550
Number of HSP's successfully gapped in prelim test: 423
Number of HSP's that attempted gapping in prelim test: 15592
Number of HSP's gapped (non-prelim): 8558
length of query: 751
length of database: 18,247,518
effective HSP length: 110
effective length of query: 641
effective length of database: 14,082,258
effective search space: 9026727378
effective search space used: 9026727378
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.