Guide to the Human Genome
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Search of human proteins with 113865883

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|113865883 WD repeat domain 38 [Homo sapiens]
         (314 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|113865883 WD repeat domain 38 [Homo sapiens]                       654   0.0  
gi|32189425 WD repeat domain 69 [Homo sapiens]                        164   1e-40
gi|4557741 platelet-activating factor acetylhydrolase, isoform I...   145   6e-35
gi|157266266 WD repeat domain 86 [Homo sapiens]                       142   3e-34
gi|21071067 TBP-associated factor 5 [Homo sapiens]                    137   9e-33
gi|16554629 WD repeat domain 5 [Homo sapiens]                         134   1e-31
gi|16554627 WD repeat domain 5 [Homo sapiens]                         134   1e-31
gi|23199987 WD repeat domain 5B [Homo sapiens]                        134   1e-31
gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo ...   132   4e-31
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]    130   2e-30
gi|26665869 WD repeat domain 51B [Homo sapiens]                       130   2e-30
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]            125   4e-29
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]            125   4e-29
gi|62234461 Notchless gene homolog isoform a [Homo sapiens]           125   4e-29
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]            125   6e-29
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]   123   2e-28
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [...   122   3e-28
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa...   122   4e-28
gi|13376840 WD repeat domain 61 [Homo sapiens]                        122   5e-28
gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo ...   120   2e-27
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]      119   3e-27
gi|189571685 WD repeat, sterile alpha motif and U-box domain con...   119   3e-27
gi|189571683 WD repeat, sterile alpha motif and U-box domain con...   119   3e-27
gi|189571681 WD repeat, sterile alpha motif and U-box domain con...   119   3e-27
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                    119   5e-27
gi|8923881 WD SOCS-box protein 2 [Homo sapiens]                       118   8e-27
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [...   115   5e-26
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H...   113   2e-25
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H...   113   2e-25
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H...   113   2e-25

>gi|113865883 WD repeat domain 38 [Homo sapiens]
          Length = 314

 Score =  654 bits (1688), Expect = 0.0
 Identities = 314/314 (100%), Positives = 314/314 (100%)

Query: 1   MNSGVPATLAVRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLG 60
           MNSGVPATLAVRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLG
Sbjct: 1   MNSGVPATLAVRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLG 60

Query: 61  GHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQL 120
           GHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQL
Sbjct: 61  GHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQL 120

Query: 121 ASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVT 180
           ASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVT
Sbjct: 121 ASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVT 180

Query: 181 PAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIA 240
           PAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIA
Sbjct: 181 PAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIA 240

Query: 241 FSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
           FSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR
Sbjct: 241 FSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300

Query: 301 QISRTSKSPRDPQT 314
           QISRTSKSPRDPQT
Sbjct: 301 QISRTSKSPRDPQT 314


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score =  164 bits (414), Expect = 1e-40
 Identities = 88/283 (31%), Positives = 144/283 (50%), Gaps = 5/283 (1%)

Query: 20  HGGEVNSSAFS-PDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLF 78
           H   V + AF+ P G  + TGS D     W   +G+      GHT  +    F+P   L 
Sbjct: 133 HRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLV 192

Query: 79  ASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQ 138
           A+ S D T +LWD+   + +  L+GH   + ++SF+    ++ +G +D  V++WD  +G+
Sbjct: 193 ATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGR 252

Query: 139 MLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCL 198
            + +L+GH   I S+ F+   + + TGS D T  +WD    T       L GH   I   
Sbjct: 253 KVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWD---ATNGKCVATLTGHDDEILDS 309

Query: 199 CYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMV 257
           C+  +G L+A+ S D T  I+   T   + +L+GH   +  I+F+P    L +    +  
Sbjct: 310 CFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTA 369

Query: 258 KVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
           ++WD  TG+CL+ L+G  D   +CAF   G I+++G+ D T R
Sbjct: 370 RIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCR 412



 Score =  134 bits (338), Expect = 8e-32
 Identities = 79/251 (31%), Positives = 125/251 (49%), Gaps = 5/251 (1%)

Query: 59  LGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFS-PDS 117
           L  H  P+     +  G  F + S D T +LWD A  + L  L+GH+  V  ++F+ P  
Sbjct: 88  LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYG 147

Query: 118 RQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLR 177
            ++A+G +DK   LW V++G+      GH   I    F+P    +ATGS D+T  +WD++
Sbjct: 148 DKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQ 207

Query: 178 MVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWV 236
                 +   L GHSA I  L ++ SG  + +GS+D T+ +W   T   +  L GH   +
Sbjct: 208 NGEEVYT---LRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEI 264

Query: 237 KSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAAD 296
            S +F+ D   + +    +  K+WD   GKC+ TL G  D      F   GK++ + +AD
Sbjct: 265 SSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASAD 324

Query: 297 QTRRQISRTSK 307
            T R  S  ++
Sbjct: 325 GTARIFSAATR 335



 Score =  119 bits (299), Expect = 3e-27
 Identities = 73/245 (29%), Positives = 113/245 (46%), Gaps = 4/245 (1%)

Query: 17  FGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGH 76
           F  H  E+   +F+P   ++ TGS D     W+ ++G+ ++ L GH+  +    F+  G 
Sbjct: 173 FRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGD 232

Query: 77  LFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQS 136
              + S D TV +WD    + + +L GH   + + SF+ D   + +G  DK   LWD  +
Sbjct: 233 RIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATN 292

Query: 137 GQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANIS 196
           G+ +  L GH D I  S F  T   +AT S D T  I+             LEGH   IS
Sbjct: 293 GKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFS---AATRKCIAKLEGHEGEIS 349

Query: 197 CLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSR 255
            + ++  G  L +GS DKT  IW   T   L  L+GH   + S AF+     + +     
Sbjct: 350 KISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDN 409

Query: 256 MVKVW 260
             ++W
Sbjct: 410 TCRIW 414



 Score =  116 bits (291), Expect = 2e-26
 Identities = 60/163 (36%), Positives = 90/163 (55%)

Query: 12  RRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRF 71
           R+V     H  E++S++F+ D  ++LTGS D     W+  +G+ +  L GH   +    F
Sbjct: 252 RKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCF 311

Query: 72  SPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVML 131
              G L A+AS D T R++  A  KC+  L+GH+  +  +SF+P    L +G  DK   +
Sbjct: 312 DYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARI 371

Query: 132 WDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIW 174
           WD Q+GQ L++L GH D I S  F+   N + TGS D+T  IW
Sbjct: 372 WDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414



 Score =  105 bits (261), Expect = 7e-23
 Identities = 62/201 (30%), Positives = 92/201 (45%), Gaps = 4/201 (1%)

Query: 20  HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
           H  E+ S +F+  G  ++TGS D  V  W+  +G+ +  L GH   +    F+ D  L  
Sbjct: 218 HSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLIL 277

Query: 80  SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
           + S D T +LWD    KC+  L GH   +    F    + +A+   D    ++   + + 
Sbjct: 278 TGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKC 337

Query: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANI-SCL 198
           +  L GH   I    F+P  N L TGS D T  IWD +        Q LEGH+  I SC 
Sbjct: 338 IAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQT---GQCLQVLEGHTDEIFSCA 394

Query: 199 CYSASGLLASGSWDKTIHIWK 219
                 ++ +GS D T  IW+
Sbjct: 395 FNYKGNIVITGSKDNTCRIWR 415



 Score =  101 bits (251), Expect = 1e-21
 Identities = 59/202 (29%), Positives = 102/202 (50%), Gaps = 5/202 (2%)

Query: 99  RVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDF-SP 157
           +VLK H   +  V+ +       +G +D+   LWD  SG+ L  L GHR+ + +  F +P
Sbjct: 86  KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNP 145

Query: 158 TVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYS-ASGLLASGSWDKTIH 216
             + +ATGS+D T  +W    V     +    GH+A I CL ++  S L+A+GS D T  
Sbjct: 146 YGDKIATGSFDKTCKLWS---VETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAK 202

Query: 217 IWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLD 276
           +W       +  L+GH   + S++F+     + +  +   V VWD +TG+ +  L G   
Sbjct: 203 LWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCA 262

Query: 277 VAHTCAFTPDGKILVSGAADQT 298
              + +F  D  ++++G+ D+T
Sbjct: 263 EISSASFNWDCSLILTGSMDKT 284



 Score = 70.5 bits (171), Expect = 2e-12
 Identities = 39/162 (24%), Positives = 74/162 (45%), Gaps = 5/162 (3%)

Query: 139 MLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCL 198
           + ++L  H   + +   + + +C  TGS+D T  +WD            LEGH   +  +
Sbjct: 84  LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWD---TASGEELNTLEGHRNVVYAI 140

Query: 199 CYS--ASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRM 256
            ++      +A+GS+DKT  +W   T       +GH   +  ++F+P    +A+      
Sbjct: 141 AFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTT 200

Query: 257 VKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQT 298
            K+WD   G+ + TL+G      + +F   G  +++G+ D T
Sbjct: 201 AKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHT 242


>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
           alpha subunit [Homo sapiens]
          Length = 410

 Score =  145 bits (365), Expect = 6e-35
 Identities = 84/300 (28%), Positives = 138/300 (46%), Gaps = 24/300 (8%)

Query: 20  HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
           H   V    F P   ++++ SED  +  W+  +G     L GHT  V+   F   G L A
Sbjct: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLA 166

Query: 80  SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
           S S D T++LWD    +C+R + GH  +V +V+  P+   + S   DK + +W+VQ+G  
Sbjct: 167 SCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYC 226

Query: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLC 199
           ++   GHR+ ++    +     +A+ S D TV +W   +V        L  H   + C+ 
Sbjct: 227 VKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW---VVATKECKAELREHEHVVECIS 283

Query: 200 YS----------ASG-----------LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKS 238
           ++          A+G            L SGS DKTI +W  +T   L+ L GH  WV+ 
Sbjct: 284 WAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRG 343

Query: 239 IAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQT 298
           + F     ++ S    + ++VWD    +C++TL        +  F      +V+G+ DQT
Sbjct: 344 VLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQT 403



 Score =  117 bits (293), Expect = 1e-26
 Identities = 77/265 (29%), Positives = 121/265 (45%), Gaps = 24/265 (9%)

Query: 57  WRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPD 116
           + L GH  PV    F P   +  SAS D T+++WD       R LKGH  SV+ +SF   
Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHS 161

Query: 117 SRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDL 176
            + LAS   D  + LWD Q  + +R + GH  ++ S    P  + + + S D T+ +W+ 
Sbjct: 162 GKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWE- 220

Query: 177 RMVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTW 235
             V      +   GH   +  +  +  G L+AS S D+T+ +W   T     +L+ H   
Sbjct: 221 --VQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHV 278

Query: 236 VKSIAFSPDELW--------------------LASAGYSRMVKVWDCNTGKCLETLKGVL 275
           V+ I+++P+  +                    L S    + +K+WD +TG CL TL G  
Sbjct: 279 VECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHD 338

Query: 276 DVAHTCAFTPDGKILVSGAADQTRR 300
           +      F   GK ++S A D+T R
Sbjct: 339 NWVRGVLFHSGGKFILSCADDKTLR 363



 Score = 88.2 bits (217), Expect = 9e-18
 Identities = 62/220 (28%), Positives = 90/220 (40%), Gaps = 62/220 (28%)

Query: 20  HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
           H   V+S A  P+G  +++ S D  +  WE ++G  +    GH   V+  R + DG L A
Sbjct: 191 HDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIA 250

Query: 80  SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQ-------------------- 119
           S S D TVR+W VA  +C   L+ H+  VE +S++P+S                      
Sbjct: 251 SCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPF 310

Query: 120 LASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQ---------------------------- 151
           L SG  DK + +WDV +G  L  LVGH + ++                            
Sbjct: 311 LLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNK 370

Query: 152 --------------SSDFSPTVNCLATGSWDSTVHIWDLR 177
                         S DF  T   + TGS D TV +W+ R
Sbjct: 371 RCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410


>gi|157266266 WD repeat domain 86 [Homo sapiens]
          Length = 376

 Score =  142 bits (359), Expect = 3e-34
 Identities = 93/266 (34%), Positives = 124/266 (46%), Gaps = 24/266 (9%)

Query: 20  HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
           H G +N  + SPDGQ LLTGSEDG    W T  GQ    L GH   V FC+   +     
Sbjct: 14  HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTC 73

Query: 80  SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
           SA  DCT+R WDV   +CL+V +GH   V  +  +  + QL S  +D+   +W V  GQM
Sbjct: 74  SA--DCTIRRWDVLTGQCLQVYRGHTSIVNRILVA--NNQLFSSSYDRTARVWSVDKGQM 129

Query: 140 LRLLVGHRDSIQSSDFS-----PTVNC---------LATGSWDSTVHIWDLRMVTPAVSH 185
            R   GHR+ + +  +S     P+  C         L TGS D T  +W    V     H
Sbjct: 130 SREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVW---QVASGCCH 186

Query: 186 QALEGHSANISCLCYSASGLLA-SGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPD 244
           Q L GH+  + CL     G  A +GS D TI  W   +   L   + H   V  +     
Sbjct: 187 QTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNR 246

Query: 245 ELWLASAGYSRMVKVWDCNTGKCLET 270
            ++  SA   R VK W  +TG+C+ T
Sbjct: 247 LVYSGSA--DRTVKCWLADTGECVRT 270



 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 57/217 (26%), Positives = 87/217 (40%), Gaps = 20/217 (9%)

Query: 98  LRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSP 157
           LRV   H+  +  +S SPD ++L +G  D    LW    GQ   LL GH   +       
Sbjct: 8   LRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLED 67

Query: 158 TVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHI 217
                 T S D T+  WD   V      Q   GH++ ++ +   A+  L S S+D+T  +
Sbjct: 68  --EAAFTCSADCTIRRWD---VLTGQCLQVYRGHTSIVNRILV-ANNQLFSSSYDRTARV 121

Query: 218 WKPTTSSLLIQLKGHVTWVKSIAFS-PDEL-------------WLASAGYSRMVKVWDCN 263
           W      +  + +GH   V ++A+S P +L              L +       KVW   
Sbjct: 122 WSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVA 181

Query: 264 TGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
           +G C +TL+G             G    +G+ D T R
Sbjct: 182 SGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIR 218



 Score = 65.9 bits (159), Expect = 5e-11
 Identities = 46/158 (29%), Positives = 65/158 (41%), Gaps = 6/158 (3%)

Query: 20  HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
           H G V        G    TGS D  +  W+  SG+ L     H G V          L  
Sbjct: 192 HTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELV--NRLVY 249

Query: 80  SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
           S S D TV+ W     +C+R    H+R+V  + +   +  L +G  D     +D QSG++
Sbjct: 250 SGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGT--LFTGSGDACARAFDAQSGEL 307

Query: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLR 177
            R+  GH   I        V  L T S D  + +WD+R
Sbjct: 308 RRVFRGHTFIINCIQVHGQV--LYTASHDGALRLWDVR 343


>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score =  137 bits (346), Expect = 9e-33
 Identities = 78/206 (37%), Positives = 107/206 (51%), Gaps = 4/206 (1%)

Query: 14  VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSP 73
           +K    H G V  ++FSPD   LL+ SEDG V  W  ++   L    GH  PV   +FSP
Sbjct: 536 LKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSP 595

Query: 74  DGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 133
            G+ F S   D   RLW     + LR+  GH   V    F P+S  +A+G  D+ V LWD
Sbjct: 596 YGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWD 655

Query: 134 VQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSA 193
           V +G  +R+  GH+  I S  FSP    LATG+ D  V +WD   +   +    L+GH+ 
Sbjct: 656 VLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWD---IGHGLMVGELKGHTD 712

Query: 194 NISCLCYSASG-LLASGSWDKTIHIW 218
            +  L +S  G +LASGS D T+ +W
Sbjct: 713 TVCSLRFSRDGEILASGSMDNTVRLW 738



 Score =  125 bits (313), Expect = 6e-29
 Identities = 77/204 (37%), Positives = 100/204 (49%), Gaps = 4/204 (1%)

Query: 59  LGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSR 118
           L GH+GPV    FSPD +   S+S D TVRLW +    CL   KGH   V    FSP   
Sbjct: 539 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGY 598

Query: 119 QLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRM 178
              SGG D+   LW     Q LR+  GH   +  + F P  N +ATGS D TV +WD   
Sbjct: 599 YFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWD--- 655

Query: 179 VTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVK 237
           V      +   GH   I  L +S +G  LA+G+ D  + +W      ++ +LKGH   V 
Sbjct: 656 VLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVC 715

Query: 238 SIAFSPDELWLASAGYSRMVKVWD 261
           S+ FS D   LAS      V++WD
Sbjct: 716 SLRFSRDGEILASGSMDNTVRLWD 739



 Score =  121 bits (303), Expect = 9e-28
 Identities = 63/156 (40%), Positives = 86/156 (55%)

Query: 20  HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
           H   V  + FSP G   ++G  D     W T   Q L    GH   V   RF P+ +  A
Sbjct: 584 HNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVA 643

Query: 80  SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
           + S D TVRLWDV    C+R+  GH+  + +++FSP+ R LA+G  D RV+LWD+  G M
Sbjct: 644 TGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLM 703

Query: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWD 175
           +  L GH D++ S  FS     LA+GS D+TV +WD
Sbjct: 704 VGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739



 Score =  108 bits (271), Expect = 5e-24
 Identities = 77/270 (28%), Positives = 115/270 (42%), Gaps = 15/270 (5%)

Query: 32  DGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWD 91
           D  ++  G  D  V  W     +L           +  + + D  L    S D   R+ D
Sbjct: 481 DSSLIAGGFADSTVRVWSVTPKKL-----------RSVKQASDLSLIDKESDDVLERIMD 529

Query: 92  VARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQ 151
              A  L++L GH   V   SFSPD   L S   D  V LW +Q+   L    GH   + 
Sbjct: 530 EKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVW 589

Query: 152 SSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSA-SGLLASGS 210
            + FSP      +G  D    +W      P    +   GH A+++C  +   S  +A+GS
Sbjct: 590 DTQFSPYGYYFVSGGHDRVARLWATDHYQPL---RIFAGHLADVNCTRFHPNSNYVATGS 646

Query: 211 WDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLET 270
            D+T+ +W     + +    GH   + S+ FSP+  +LA+      V +WD   G  +  
Sbjct: 647 ADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGE 706

Query: 271 LKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
           LKG  D   +  F+ DG+IL SG+ D T R
Sbjct: 707 LKGHTDTVCSLRFSRDGEILASGSMDNTVR 736



 Score = 87.0 bits (214), Expect = 2e-17
 Identities = 46/127 (36%), Positives = 65/127 (51%)

Query: 7   ATLAVRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPV 66
           AT   + ++ F  H  +VN + F P+   + TGS D  V  W+  +G  +    GH GP+
Sbjct: 613 ATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPI 672

Query: 67  KFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWD 126
               FSP+G   A+ + D  V LWD+     +  LKGH  +V ++ FS D   LASG  D
Sbjct: 673 HSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMD 732

Query: 127 KRVMLWD 133
             V LWD
Sbjct: 733 NTVRLWD 739



 Score = 75.5 bits (184), Expect = 6e-14
 Identities = 38/82 (46%), Positives = 49/82 (59%)

Query: 14  VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSP 73
           V+ F  H G ++S  FSP+G+ L TG+ DG V  W+   G ++  L GHT  V   RFS 
Sbjct: 662 VRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSR 721

Query: 74  DGHLFASASCDCTVRLWDVARA 95
           DG + AS S D TVRLWD  +A
Sbjct: 722 DGEILASGSMDNTVRLWDAIKA 743



 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 45/176 (25%), Positives = 71/176 (40%), Gaps = 29/176 (16%)

Query: 154 DFSPTVNCLATGSWDSTVHIW--------------DLRMV--------------TPAVSH 185
           D +   + +A G  DSTV +W              DL ++                A   
Sbjct: 477 DVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASEL 536

Query: 186 QALEGHSANISCLCYSAS-GLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPD 244
           + L GHS  +    +S     L S S D T+ +W   T + L+  KGH   V    FSP 
Sbjct: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPY 596

Query: 245 ELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
             +  S G+ R+ ++W  +  + L    G L   +   F P+   + +G+AD+T R
Sbjct: 597 GYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVR 652


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  134 bits (337), Expect = 1e-31
 Identities = 79/285 (27%), Positives = 139/285 (48%), Gaps = 8/285 (2%)

Query: 20  HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
           H   V+S  FSP+G+ L + S D  +  W    G+    + GH   +    +S D +L  
Sbjct: 44  HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV 103

Query: 80  SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
           SAS D T+++WDV+  KCL+ LKGH   V   +F+P S  + SG +D+ V +WDV++G+ 
Sbjct: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC 163

Query: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLC 199
           L+ L  H D + +  F+   + + + S+D    IWD    +       ++  +  +S + 
Sbjct: 164 LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD--TASGQCLKTLIDDDNPPVSFVK 221

Query: 200 YSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDEL----WLASAGYS 254
           +S +G  + + + D T+ +W  +    L    GH    K   F+   +    W+ S    
Sbjct: 222 FSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKN-EKYCIFANFSVTGGKWIVSGSED 280

Query: 255 RMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTR 299
            +V +W+  T + ++ L+G  DV  + A  P   I+ S A +  +
Sbjct: 281 NLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDK 325



 Score =  133 bits (335), Expect = 2e-31
 Identities = 83/251 (33%), Positives = 130/251 (51%), Gaps = 16/251 (6%)

Query: 55  LLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFS 114
           L + L GHT  V   +FSP+G   AS+S D  +++W     K  + + GH+  +  V++S
Sbjct: 37  LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96

Query: 115 PDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIW 174
            DS  L S   DK + +WDV SG+ L+ L GH + +   +F+P  N + +GS+D +V IW
Sbjct: 97  SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156

Query: 175 DLRMVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQL---- 229
           D   V      + L  HS  +S + ++  G L+ S S+D    IW   +   L  L    
Sbjct: 157 D---VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 213

Query: 230 KGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAF----TP 285
              V++VK   FSP+  ++ +A     +K+WD + GKCL+T  G  +  + C F      
Sbjct: 214 NPPVSFVK---FSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKY-CIFANFSVT 269

Query: 286 DGKILVSGAAD 296
            GK +VSG+ D
Sbjct: 270 GGKWIVSGSED 280



 Score =  127 bits (319), Expect = 1e-29
 Identities = 80/257 (31%), Positives = 124/257 (48%), Gaps = 12/257 (4%)

Query: 15  KFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPD 74
           K    H   ++  A+S D  +L++ S+D  +  W+  SG+ L  L GH+  V  C F+P 
Sbjct: 81  KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ 140

Query: 75  GHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDV 134
            +L  S S D +VR+WDV   KCL+ L  H   V  V F+ D   + S  +D    +WD 
Sbjct: 141 SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200

Query: 135 QSGQMLRLLV-GHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSA 193
            SGQ L+ L+      +    FSP    +   + D+T+ +WD    +     +   GH  
Sbjct: 201 ASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD---YSKGKCLKTYTGHKN 257

Query: 194 NISCLC--YSASG--LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLA 249
              C+   +S +G   + SGS D  ++IW   T  ++ +L+GH   V S A  P E  +A
Sbjct: 258 EKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIA 317

Query: 250 SAGY--SRMVKVW--DC 262
           SA     + +K+W  DC
Sbjct: 318 SAALENDKTIKLWKSDC 334



 Score = 97.1 bits (240), Expect = 2e-20
 Identities = 54/167 (32%), Positives = 92/167 (55%), Gaps = 6/167 (3%)

Query: 14  VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRL-GGHTGPVKFCRFS 72
           +K    H   V++  F+ DG ++++ S DG    W+T SGQ L  L      PV F +FS
Sbjct: 164 LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFS 223

Query: 73  PDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETV--SFS-PDSRQLASGGWDKRV 129
           P+G    +A+ D T++LWD ++ KCL+   GH+     +  +FS    + + SG  D  V
Sbjct: 224 PNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLV 283

Query: 130 MLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSW--DSTVHIW 174
            +W++Q+ ++++ L GH D + S+   PT N +A+ +   D T+ +W
Sbjct: 284 YIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330



 Score = 79.7 bits (195), Expect = 3e-15
 Identities = 42/114 (36%), Positives = 63/114 (55%), Gaps = 1/114 (0%)

Query: 188 LEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDEL 246
           L GH+  +S + +S +G  LAS S DK I IW          + GH   +  +A+S D  
Sbjct: 41  LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100

Query: 247 WLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
            L SA   + +K+WD ++GKCL+TLKG  +    C F P   ++VSG+ D++ R
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  134 bits (337), Expect = 1e-31
 Identities = 79/285 (27%), Positives = 139/285 (48%), Gaps = 8/285 (2%)

Query: 20  HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
           H   V+S  FSP+G+ L + S D  +  W    G+    + GH   +    +S D +L  
Sbjct: 44  HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV 103

Query: 80  SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
           SAS D T+++WDV+  KCL+ LKGH   V   +F+P S  + SG +D+ V +WDV++G+ 
Sbjct: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC 163

Query: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLC 199
           L+ L  H D + +  F+   + + + S+D    IWD    +       ++  +  +S + 
Sbjct: 164 LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD--TASGQCLKTLIDDDNPPVSFVK 221

Query: 200 YSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDEL----WLASAGYS 254
           +S +G  + + + D T+ +W  +    L    GH    K   F+   +    W+ S    
Sbjct: 222 FSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKN-EKYCIFANFSVTGGKWIVSGSED 280

Query: 255 RMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTR 299
            +V +W+  T + ++ L+G  DV  + A  P   I+ S A +  +
Sbjct: 281 NLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDK 325



 Score =  133 bits (335), Expect = 2e-31
 Identities = 83/251 (33%), Positives = 130/251 (51%), Gaps = 16/251 (6%)

Query: 55  LLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFS 114
           L + L GHT  V   +FSP+G   AS+S D  +++W     K  + + GH+  +  V++S
Sbjct: 37  LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96

Query: 115 PDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIW 174
            DS  L S   DK + +WDV SG+ L+ L GH + +   +F+P  N + +GS+D +V IW
Sbjct: 97  SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156

Query: 175 DLRMVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQL---- 229
           D   V      + L  HS  +S + ++  G L+ S S+D    IW   +   L  L    
Sbjct: 157 D---VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 213

Query: 230 KGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAF----TP 285
              V++VK   FSP+  ++ +A     +K+WD + GKCL+T  G  +  + C F      
Sbjct: 214 NPPVSFVK---FSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKY-CIFANFSVT 269

Query: 286 DGKILVSGAAD 296
            GK +VSG+ D
Sbjct: 270 GGKWIVSGSED 280



 Score =  127 bits (319), Expect = 1e-29
 Identities = 80/257 (31%), Positives = 124/257 (48%), Gaps = 12/257 (4%)

Query: 15  KFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPD 74
           K    H   ++  A+S D  +L++ S+D  +  W+  SG+ L  L GH+  V  C F+P 
Sbjct: 81  KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ 140

Query: 75  GHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDV 134
            +L  S S D +VR+WDV   KCL+ L  H   V  V F+ D   + S  +D    +WD 
Sbjct: 141 SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200

Query: 135 QSGQMLRLLV-GHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSA 193
            SGQ L+ L+      +    FSP    +   + D+T+ +WD    +     +   GH  
Sbjct: 201 ASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD---YSKGKCLKTYTGHKN 257

Query: 194 NISCLC--YSASG--LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLA 249
              C+   +S +G   + SGS D  ++IW   T  ++ +L+GH   V S A  P E  +A
Sbjct: 258 EKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIA 317

Query: 250 SAGY--SRMVKVW--DC 262
           SA     + +K+W  DC
Sbjct: 318 SAALENDKTIKLWKSDC 334



 Score = 97.1 bits (240), Expect = 2e-20
 Identities = 54/167 (32%), Positives = 92/167 (55%), Gaps = 6/167 (3%)

Query: 14  VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRL-GGHTGPVKFCRFS 72
           +K    H   V++  F+ DG ++++ S DG    W+T SGQ L  L      PV F +FS
Sbjct: 164 LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFS 223

Query: 73  PDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETV--SFS-PDSRQLASGGWDKRV 129
           P+G    +A+ D T++LWD ++ KCL+   GH+     +  +FS    + + SG  D  V
Sbjct: 224 PNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLV 283

Query: 130 MLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSW--DSTVHIW 174
            +W++Q+ ++++ L GH D + S+   PT N +A+ +   D T+ +W
Sbjct: 284 YIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330



 Score = 79.7 bits (195), Expect = 3e-15
 Identities = 42/114 (36%), Positives = 63/114 (55%), Gaps = 1/114 (0%)

Query: 188 LEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDEL 246
           L GH+  +S + +S +G  LAS S DK I IW          + GH   +  +A+S D  
Sbjct: 41  LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100

Query: 247 WLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
            L SA   + +K+WD ++GKCL+TLKG  +    C F P   ++VSG+ D++ R
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score =  134 bits (336), Expect = 1e-31
 Identities = 85/247 (34%), Positives = 130/247 (52%), Gaps = 16/247 (6%)

Query: 59  LGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSR 118
           L GHT  V   +FSP+G   AS+S D  + +W     K  + L GH   +  V++S DS 
Sbjct: 37  LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSS 96

Query: 119 QLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRM 178
           +L S   DK + LWDV+SG+ L+ L GH + +   +F+P  N + +GS+D TV IW+   
Sbjct: 97  RLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWE--- 153

Query: 179 VTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQL----KGHV 233
           V      + L  HS  +S + ++ SG L+ SGS+D    IW   +   L  L       V
Sbjct: 154 VKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPV 213

Query: 234 TWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAF----TPDGKI 289
           ++VK   FSP+  ++ +A     +K+WD + G+CL+T  G  +  + C F       GK 
Sbjct: 214 SFVK---FSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKY-CIFANFSVTGGKW 269

Query: 290 LVSGAAD 296
           +VSG+ D
Sbjct: 270 IVSGSED 276



 Score =  132 bits (332), Expect = 4e-31
 Identities = 83/289 (28%), Positives = 140/289 (48%), Gaps = 16/289 (5%)

Query: 20  HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
           H   V+S  FSP+G+ L + S D  +  W    G+    L GH   +    +S D     
Sbjct: 40  HTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLV 99

Query: 80  SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
           SAS D T++LWDV   KCL+ LKGH   V   +F+P S  + SG +D+ V +W+V++G+ 
Sbjct: 100 SASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKC 159

Query: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQAL----EGHSANI 195
           L+ L  H D + +  F+ + + + +GS+D    IWD      A S Q L    +  +  +
Sbjct: 160 LKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD------AASGQCLKTLVDDDNPPV 213

Query: 196 SCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDEL----WLAS 250
           S + +S +G  + + + D T+ +W  +    L    GH    K   F+   +    W+ S
Sbjct: 214 SFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKN-EKYCIFANFSVTGGKWIVS 272

Query: 251 AGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTR 299
                +V +W+  T + ++ L+G  DV  + A  P   ++ S A +  +
Sbjct: 273 GSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDK 321



 Score = 95.5 bits (236), Expect = 5e-20
 Identities = 53/167 (31%), Positives = 91/167 (54%), Gaps = 6/167 (3%)

Query: 14  VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRL-GGHTGPVKFCRFS 72
           +K    H   V++  F+  G ++++GS DG    W+  SGQ L  L      PV F +FS
Sbjct: 160 LKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFS 219

Query: 73  PDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETV--SFS-PDSRQLASGGWDKRV 129
           P+G    +A+ D T++LWD +R +CL+   GH+     +  +FS    + + SG  D  V
Sbjct: 220 PNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLV 279

Query: 130 MLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSW--DSTVHIW 174
            +W++Q+ ++++ L GH D + S+   PT N +A+ +   D T+ +W
Sbjct: 280 YIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326



 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 35/136 (25%), Positives = 55/136 (40%), Gaps = 42/136 (30%)

Query: 205 LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMV------- 257
           L  S S +++  + +    +L   L GH   V S+ FSP+  WLAS+   R++       
Sbjct: 13  LALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYD 72

Query: 258 -----------------------------------KVWDCNTGKCLETLKGVLDVAHTCA 282
                                              K+WD  +GKCL+TLKG  +    C 
Sbjct: 73  GKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCN 132

Query: 283 FTPDGKILVSGAADQT 298
           F P   +++SG+ D+T
Sbjct: 133 FNPPSNLIISGSFDET 148


>gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo
           sapiens]
          Length = 421

 Score =  132 bits (332), Expect = 4e-31
 Identities = 91/270 (33%), Positives = 134/270 (49%), Gaps = 35/270 (12%)

Query: 29  FSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLF-ASASCDCTV 87
           F  D  +L TG  +G +  W+  +G+LL  L  HT  V+   F+PDG L   SAS D T+
Sbjct: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195

Query: 88  RLWDVAR-AKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGH 146
           R+WD+      ++VL+GHQ  V + +FSPDS  L S G  K V LW++    M+R L GH
Sbjct: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255

Query: 147 RDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLL 206
              + + DFSP    LAT S+D+ V+IWD               H+ +I         L+
Sbjct: 256 HHDVVACDFSPDGALLATASYDTRVYIWD--------------PHNGDI---------LM 292

Query: 207 ASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGK 266
             G      H++ P T   +     +  WV+S++FS D L +AS    +MV+ W  +   
Sbjct: 293 EFG------HLFPPPTP--IFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDY 344

Query: 267 CLETLKGVLDVAHTCAFTPDGKILVSGAAD 296
            ++     L     CAF+ DG +L +G  D
Sbjct: 345 PVQV--APLSNGLCCAFSTDGSVLAAGTHD 372



 Score = 86.3 bits (212), Expect = 3e-17
 Identities = 64/224 (28%), Positives = 104/224 (46%), Gaps = 14/224 (6%)

Query: 84  DCTVRLWDVARAKCLRVLKGHQRSVE--TVSFSPDSRQLASGGWDKRVMLWDVQSGQMLR 141
           DC   +W +A    +   +    ++E     F  D   LA+G  + R+ +WDV +G++L 
Sbjct: 105 DCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLL 164

Query: 142 LLVGHRDSIQSSDFSPTVNC-LATGSWDSTVHIWDLRMVTPAVSHQALEGHSANI-SCLC 199
            LV H + ++   F+P  +  L + S D T+ +WDL+        + L GH   + SC  
Sbjct: 165 NLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLK--DDGNMMKVLRGHQNWVYSCAF 222

Query: 200 YSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKV 259
              S +L S    K + +W     +++ +L+GH   V +  FSPD   LA+A Y   V +
Sbjct: 223 SPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYI 282

Query: 260 WDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRRQIS 303
           WD + G  L      ++  H   F P   I   GA D+  R +S
Sbjct: 283 WDPHNGDIL------MEFGH--LFPPPTPIFAGGANDRWVRSVS 318



 Score = 76.3 bits (186), Expect = 3e-14
 Identities = 58/186 (31%), Positives = 78/186 (41%), Gaps = 17/186 (9%)

Query: 14  VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSP 73
           +K    H   V S AFSPD  ML +      V+ W      ++ +L GH   V  C FSP
Sbjct: 207 MKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSP 266

Query: 74  DGHLFASASCDCTVRLWDVARAKCLRVLKGH--------------QRSVETVSFSPDSRQ 119
           DG L A+AS D  V +WD      L    GH               R V +VSFS D   
Sbjct: 267 DGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLH 325

Query: 120 LASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMV 179
           +AS   DK V  W +     ++  V    +     FS   + LA G+ D +V+ W     
Sbjct: 326 VASLADDKMVRFWRIDEDYPVQ--VAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQ 383

Query: 180 TPAVSH 185
            P++ H
Sbjct: 384 VPSLQH 389



 Score = 75.1 bits (183), Expect = 8e-14
 Identities = 67/241 (27%), Positives = 109/241 (45%), Gaps = 20/241 (8%)

Query: 71  FSPDGHLFASASCDCTVRLWDVARAKCLRVLKGH-QRSVETVSFSPDSRQLASGGWDKRV 129
           F+PDG  FA +    TV+L  V  ++CL+    H  ++V   S     RQ + GG   + 
Sbjct: 42  FAPDGSYFAWSQGHRTVKL--VPWSQCLQNFLLHGTKNVTNSSSLRLPRQNSDGGQKNKP 99

Query: 130 ---------MLWDVQSGQMLRLLVGHRDSIQ--SSDFSPTVNCLATGSWDSTVHIWDLRM 178
                    ++W +  G  +        +I+     F      LATG  +  + IWD+  
Sbjct: 100 REHIIDCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYT 159

Query: 179 VTPAVSHQALEGHSANISCLCYSASG--LLASGSWDKTIHIWK-PTTSSLLIQLKGHVTW 235
               ++   L  H+  +  L ++  G  +L S S DKT+ +W      +++  L+GH  W
Sbjct: 160 GKLLLN---LVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNW 216

Query: 236 VKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAA 295
           V S AFSPD   L S G S+ V +W+ +    +  L+G       C F+PDG +L + + 
Sbjct: 217 VYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASY 276

Query: 296 D 296
           D
Sbjct: 277 D 277


>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
          Length = 589

 Score =  130 bits (326), Expect = 2e-30
 Identities = 80/206 (38%), Positives = 103/206 (50%), Gaps = 4/206 (1%)

Query: 14  VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSP 73
           +K    H G V S+ F  D   LL+ SED  +  W+  S        GH  PV     SP
Sbjct: 335 MKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISP 394

Query: 74  DGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 133
               FAS S D T RLW   R   LR+  GH   V+ V F P+S  LA+G  DK V LW 
Sbjct: 395 YSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWS 454

Query: 134 VQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSA 193
            Q G  +RL  GHR  + S  FSP    LA+   D  + +WDL   T    ++ L GH+ 
Sbjct: 455 AQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGT---LYKELRGHTD 511

Query: 194 NISCLCYSA-SGLLASGSWDKTIHIW 218
           NI+ L +S  SGL+AS S D ++ +W
Sbjct: 512 NITSLTFSPDSGLIASASMDNSVRVW 537



 Score =  126 bits (317), Expect = 2e-29
 Identities = 82/277 (29%), Positives = 118/277 (42%), Gaps = 36/277 (12%)

Query: 24  VNSSAFSPDGQMLLTGSEDGCVYGWETRSGQL---------------------------- 55
           +N++  SPD ++L  G ++ C+  W  RS +L                            
Sbjct: 271 LNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDN 330

Query: 56  ----LWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETV 111
               +  L GH GPV   RF  D     S S D ++R WD+       + +GH   V  +
Sbjct: 331 AGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDL 390

Query: 112 SFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTV 171
             SP S   ASG  D+   LW       LR+  GH   +    F P  N LATGS D TV
Sbjct: 391 DISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTV 450

Query: 172 HIWDLRMVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLK 230
            +W  +      S +   GH   +  L +S +G  LAS   D+ + +W   + +L  +L+
Sbjct: 451 RLWSAQQGN---SVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELR 507

Query: 231 GHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKC 267
           GH   + S+ FSPD   +ASA     V+VWD     C
Sbjct: 508 GHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYC 544



 Score = 90.1 bits (222), Expect = 2e-18
 Identities = 50/163 (30%), Positives = 79/163 (48%), Gaps = 11/163 (6%)

Query: 14  VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSP 73
           ++ +  H  +V+   F P+   L TGS D  V  W  + G  +    GH GPV    FSP
Sbjct: 419 LRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSP 478

Query: 74  DGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 133
           +G   ASA  D  ++LWD+A     + L+GH  ++ +++FSPDS  +AS   D  V +WD
Sbjct: 479 NGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWD 538

Query: 134 VQ-----------SGQMLRLLVGHRDSIQSSDFSPTVNCLATG 165
           ++           S +++ +  G   ++ S  F      L TG
Sbjct: 539 IRNTYCSAPADGSSSELVGVYTGQMSNVLSVQFMACNLLLVTG 581



 Score = 85.9 bits (211), Expect = 4e-17
 Identities = 69/269 (25%), Positives = 115/269 (42%), Gaps = 50/269 (18%)

Query: 72  SPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVML 131
           SPD  L A+   +  ++LW + R+K L+  + HQ  V  +  + D  +            
Sbjct: 277 SPDSKLLAAGFDNSCIKLWSL-RSKKLKS-EPHQVDVSRIHLACDILEEEDDE------- 327

Query: 132 WDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQA---- 187
            D  +G  +++L GH   + S+ F    + L + S D ++  WDL   T  V +Q     
Sbjct: 328 -DDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYP 386

Query: 188 -----------------------------------LEGHSANISCLCYSA-SGLLASGSW 211
                                                GH A++ C+ +   S  LA+GS 
Sbjct: 387 VWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGST 446

Query: 212 DKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETL 271
           DKT+ +W     + +    GH   V S+AFSP+  +LASAG  + +K+WD  +G   + L
Sbjct: 447 DKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKEL 506

Query: 272 KGVLDVAHTCAFTPDGKILVSGAADQTRR 300
           +G  D   +  F+PD  ++ S + D + R
Sbjct: 507 RGHTDNITSLTFSPDSGLIASASMDNSVR 535



 Score = 45.1 bits (105), Expect = 8e-05
 Identities = 45/182 (24%), Positives = 70/182 (38%), Gaps = 32/182 (17%)

Query: 150 IQSSDFSPTVNCLATGSWDSTVHIWDLR---------MVTPAVSHQA------------- 187
           + +++ SP    LA G  +S + +W LR          V  +  H A             
Sbjct: 271 LNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDN 330

Query: 188 -------LEGHSANISCLCYSA--SGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKS 238
                  L GH   +    + A  SGLL S S D +I  W   + +  +  +GH   V  
Sbjct: 331 AGTEMKILRGHCGPVYSTRFLADSSGLL-SCSEDMSIRYWDLGSFTNTVLYQGHAYPVWD 389

Query: 239 IAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQT 298
           +  SP  L+ AS  + R  ++W  +    L    G L       F P+   L +G+ D+T
Sbjct: 390 LDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKT 449

Query: 299 RR 300
            R
Sbjct: 450 VR 451


>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score =  130 bits (326), Expect = 2e-30
 Identities = 85/286 (29%), Positives = 135/286 (47%), Gaps = 10/286 (3%)

Query: 15  KFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPD 74
           ++F  H   + S   SP+G+ L T S D  +  W  +     +R  GH   V   +FSP 
Sbjct: 12  RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH 71

Query: 75  GHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDV 134
           G+L ASAS D TVRLW   +       K H   V +V FS D + LA+   DK + +W +
Sbjct: 72  GNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSM 131

Query: 135 QSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSAN 194
              + L  L  H   ++ + FSP    + + S D T+ IWD        + Q +   S +
Sbjct: 132 YRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWD------TTNKQCVNNFSDS 185

Query: 195 I---SCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLAS 250
           +   + + ++ SG  +AS   D+T+ +W    + LL   + H   V  I+F P   +L +
Sbjct: 186 VGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLIT 245

Query: 251 AGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAAD 296
           A     +K+ D   G+ + TL+G      T +F+  G++  SG AD
Sbjct: 246 ASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGAD 291



 Score =  122 bits (305), Expect = 5e-28
 Identities = 64/201 (31%), Positives = 99/201 (49%), Gaps = 4/201 (1%)

Query: 99  RVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPT 158
           R  KGH+ ++ ++  SP+ +QLA+  WD  +MLW+ +        VGH+D + S  FSP 
Sbjct: 12  RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH 71

Query: 159 VNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHI 217
            N LA+ S D TV +W   +          + H+A +  + +SA G  LA+ S DK+I +
Sbjct: 72  GNLLASASRDRTVRLW---IPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKV 128

Query: 218 WKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDV 277
           W       L  L  H  WV+   FSPD   + S    + +K+WD    +C+      +  
Sbjct: 129 WSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGF 188

Query: 278 AHTCAFTPDGKILVSGAADQT 298
           A+   F P G  + S  +DQT
Sbjct: 189 ANFVDFNPSGTCIASAGSDQT 209



 Score =  120 bits (302), Expect = 1e-27
 Identities = 79/253 (31%), Positives = 116/253 (45%), Gaps = 5/253 (1%)

Query: 12  RRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRF 71
           R  ++ G H   V S  FSP G +L + S D  V  W             HT PV+   F
Sbjct: 52  RAYRYVG-HKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDF 110

Query: 72  SPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVML 131
           S DG   A+AS D ++++W + R + L  L  H   V    FSPD R + S   DK + +
Sbjct: 111 SADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKI 170

Query: 132 WDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGH 191
           WD  + Q +             DF+P+  C+A+   D TV +WD+R V   + H  +  H
Sbjct: 171 WDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVR-VNKLLQHYQV--H 227

Query: 192 SANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLAS 250
           S  ++C+ +  SG  L + S D T+ I       L+  L+GH   V +++FS      AS
Sbjct: 228 SGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFAS 287

Query: 251 AGYSRMVKVWDCN 263
            G    V +W  N
Sbjct: 288 GGADTQVLLWRTN 300



 Score =  115 bits (287), Expect = 7e-26
 Identities = 73/220 (33%), Positives = 105/220 (47%), Gaps = 12/220 (5%)

Query: 12  RRVKF--FGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFC 69
           +R KF  F  H   V S  FS DGQ L T SED  +  W     + L+ L  HT  V+  
Sbjct: 91  KRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCA 150

Query: 70  RFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRV 129
           +FSPDG L  S S D T+++WD    +C+            V F+P    +AS G D+ V
Sbjct: 151 KFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTV 210

Query: 130 MLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDL---RMVTPAVSHQ 186
            +WDV+  ++L+    H   +    F P+ N L T S D T+ I DL   R++       
Sbjct: 211 KVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLI------Y 264

Query: 187 ALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSL 225
            L+GH+  +  + +S  G L ASG  D  + +W+     L
Sbjct: 265 TLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDEL 304



 Score =  106 bits (264), Expect = 3e-23
 Identities = 74/240 (30%), Positives = 108/240 (45%), Gaps = 6/240 (2%)

Query: 61  GHTGPVKFCRFSPDGHLFASASCDCTVRLWDVA-RAKCLRVLKGHQRSVETVSFSPDSRQ 119
           GH   +     SP+G   A+AS D  + LW+    A+  R + GH+  V +V FSP    
Sbjct: 16  GHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYV-GHKDVVTSVQFSPHGNL 74

Query: 120 LASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMV 179
           LAS   D+ V LW             H   ++S DFS     LAT S D ++ +W +   
Sbjct: 75  LASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQ 134

Query: 180 TPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKS 238
               S   L  H+  + C  +S  G L+ S S DKTI IW  T    +      V +   
Sbjct: 135 RFLYS---LYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANF 191

Query: 239 IAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQT 298
           + F+P    +ASAG  + VKVWD    K L+  +      +  +F P G  L++ ++D T
Sbjct: 192 VDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGT 251



 Score = 90.9 bits (224), Expect = 1e-18
 Identities = 54/168 (32%), Positives = 85/168 (50%), Gaps = 4/168 (2%)

Query: 141 RLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCY 200
           R   GH+ +I S D SP    LAT SWD+ + +W+ +   P        GH   ++ + +
Sbjct: 12  RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFK---PHARAYRYVGHKDVVTSVQF 68

Query: 201 SASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKV 259
           S  G LLAS S D+T+ +W P       + K H   V+S+ FS D  +LA+A   + +KV
Sbjct: 69  SPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKV 128

Query: 260 WDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRRQISRTSK 307
           W     + L +L           F+PDG+++VS + D+T +    T+K
Sbjct: 129 WSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNK 176


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score =  125 bits (315), Expect = 4e-29
 Identities = 84/284 (29%), Positives = 127/284 (44%), Gaps = 4/284 (1%)

Query: 15  KFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPD 74
           + F  H   V    FS + + L +GS D C+  W  +     +R  GH   V    FSP 
Sbjct: 13  RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72

Query: 75  GHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDV 134
           GHL AS S D TVR+W         V + H  +V +V F  D +   +   DK V +W  
Sbjct: 73  GHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWAT 132

Query: 135 QSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSAN 194
              + L  L  H + ++ + FSP    + + S D TV +WD    +    H   E H   
Sbjct: 133 HRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD--KSSRECVHSYCE-HGGF 189

Query: 195 ISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGY 253
           ++ + +  SG  +A+   D T+ +W   T  LL   + H   V  ++F P   +L +A  
Sbjct: 190 VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASS 249

Query: 254 SRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQ 297
              +K+ D   G+ L TL G    A T AF+  G+   SG +D+
Sbjct: 250 DSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDE 293



 Score =  125 bits (313), Expect = 6e-29
 Identities = 88/258 (34%), Positives = 118/258 (45%), Gaps = 15/258 (5%)

Query: 12  RRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGW--ETRSGQLLWRLGGHTGPVKFC 69
           R  +F G H   V    FSP G +L +GS D  V  W    +    ++R   HT  V+  
Sbjct: 53  RAYRFTG-HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFR--AHTATVRSV 109

Query: 70  RFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRV 129
            F  DG  F +AS D TV++W   R K L  L  H   V    FSPD R + S   DK V
Sbjct: 110 HFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTV 169

Query: 130 MLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALE 189
            LWD  S + +     H   +   DF P+  C+A    D+TV +WD+R      +H+ L+
Sbjct: 170 KLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR------THRLLQ 223

Query: 190 G---HSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDE 245
               HSA ++ L +  SG  L + S D T+ I       LL  L GH     ++AFS   
Sbjct: 224 HYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTG 283

Query: 246 LWLASAGYSRMVKVWDCN 263
            + AS G    V VW  N
Sbjct: 284 EYFASGGSDEQVMVWKSN 301



 Score =  108 bits (271), Expect = 5e-24
 Identities = 62/203 (30%), Positives = 100/203 (49%), Gaps = 8/203 (3%)

Query: 99  RVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPT 158
           R  KGH+ +V  V FS +++QLASG  D  +M+W ++         GH+D++   +FSP+
Sbjct: 13  RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72

Query: 159 VNCLATGSWDSTVHIWDLRMVTPAVSHQA--LEGHSANISCLCYSASG-LLASGSWDKTI 215
            + LA+GS D TV IW      P V  ++     H+A +  + + + G    + S DKT+
Sbjct: 73  GHLLASGSRDKTVRIW-----VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTV 127

Query: 216 HIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVL 275
            +W       L  L  H+ WV+   FSPD   + SA   + VK+WD ++ +C+ +     
Sbjct: 128 KVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHG 187

Query: 276 DVAHTCAFTPDGKILVSGAADQT 298
                  F P G  + +   D T
Sbjct: 188 GFVTYVDFHPSGTCIAAAGMDNT 210



 Score = 97.4 bits (241), Expect = 1e-20
 Identities = 55/164 (33%), Positives = 86/164 (52%), Gaps = 4/164 (2%)

Query: 145 GHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG 204
           GHRD++   DFS     LA+GS DS + +W ++   P        GH   ++C+ +S SG
Sbjct: 17  GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMK---PQSRAYRFTGHKDAVTCVNFSPSG 73

Query: 205 -LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCN 263
            LLASGS DKT+ IW P         + H   V+S+ F  D     +A   + VKVW  +
Sbjct: 74  HLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATH 133

Query: 264 TGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRRQISRTSK 307
             K L +L   ++      F+PDG+++VS + D+T +   ++S+
Sbjct: 134 RQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR 177



 Score = 35.8 bits (81), Expect = 0.051
 Identities = 24/77 (31%), Positives = 31/77 (40%)

Query: 224 SLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAF 283
           SL    KGH   V  + FS +   LAS      + VW            G  D      F
Sbjct: 10  SLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNF 69

Query: 284 TPDGKILVSGAADQTRR 300
           +P G +L SG+ D+T R
Sbjct: 70  SPSGHLLASGSRDKTVR 86


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score =  125 bits (315), Expect = 4e-29
 Identities = 84/284 (29%), Positives = 127/284 (44%), Gaps = 4/284 (1%)

Query: 15  KFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPD 74
           + F  H   V    FS + + L +GS D C+  W  +     +R  GH   V    FSP 
Sbjct: 13  RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72

Query: 75  GHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDV 134
           GHL AS S D TVR+W         V + H  +V +V F  D +   +   DK V +W  
Sbjct: 73  GHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWAT 132

Query: 135 QSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSAN 194
              + L  L  H + ++ + FSP    + + S D TV +WD    +    H   E H   
Sbjct: 133 HRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD--KSSRECVHSYCE-HGGF 189

Query: 195 ISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGY 253
           ++ + +  SG  +A+   D T+ +W   T  LL   + H   V  ++F P   +L +A  
Sbjct: 190 VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASS 249

Query: 254 SRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQ 297
              +K+ D   G+ L TL G    A T AF+  G+   SG +D+
Sbjct: 250 DSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDE 293



 Score =  125 bits (313), Expect = 6e-29
 Identities = 88/258 (34%), Positives = 118/258 (45%), Gaps = 15/258 (5%)

Query: 12  RRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGW--ETRSGQLLWRLGGHTGPVKFC 69
           R  +F G H   V    FSP G +L +GS D  V  W    +    ++R   HT  V+  
Sbjct: 53  RAYRFTG-HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFR--AHTATVRSV 109

Query: 70  RFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRV 129
            F  DG  F +AS D TV++W   R K L  L  H   V    FSPD R + S   DK V
Sbjct: 110 HFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTV 169

Query: 130 MLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALE 189
            LWD  S + +     H   +   DF P+  C+A    D+TV +WD+R      +H+ L+
Sbjct: 170 KLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR------THRLLQ 223

Query: 190 G---HSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDE 245
               HSA ++ L +  SG  L + S D T+ I       LL  L GH     ++AFS   
Sbjct: 224 HYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTG 283

Query: 246 LWLASAGYSRMVKVWDCN 263
            + AS G    V VW  N
Sbjct: 284 EYFASGGSDEQVMVWKSN 301



 Score =  108 bits (271), Expect = 5e-24
 Identities = 62/203 (30%), Positives = 100/203 (49%), Gaps = 8/203 (3%)

Query: 99  RVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPT 158
           R  KGH+ +V  V FS +++QLASG  D  +M+W ++         GH+D++   +FSP+
Sbjct: 13  RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72

Query: 159 VNCLATGSWDSTVHIWDLRMVTPAVSHQA--LEGHSANISCLCYSASG-LLASGSWDKTI 215
            + LA+GS D TV IW      P V  ++     H+A +  + + + G    + S DKT+
Sbjct: 73  GHLLASGSRDKTVRIW-----VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTV 127

Query: 216 HIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVL 275
            +W       L  L  H+ WV+   FSPD   + SA   + VK+WD ++ +C+ +     
Sbjct: 128 KVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHG 187

Query: 276 DVAHTCAFTPDGKILVSGAADQT 298
                  F P G  + +   D T
Sbjct: 188 GFVTYVDFHPSGTCIAAAGMDNT 210



 Score = 97.4 bits (241), Expect = 1e-20
 Identities = 55/164 (33%), Positives = 86/164 (52%), Gaps = 4/164 (2%)

Query: 145 GHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG 204
           GHRD++   DFS     LA+GS DS + +W ++   P        GH   ++C+ +S SG
Sbjct: 17  GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMK---PQSRAYRFTGHKDAVTCVNFSPSG 73

Query: 205 -LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCN 263
            LLASGS DKT+ IW P         + H   V+S+ F  D     +A   + VKVW  +
Sbjct: 74  HLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATH 133

Query: 264 TGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRRQISRTSK 307
             K L +L   ++      F+PDG+++VS + D+T +   ++S+
Sbjct: 134 RQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR 177



 Score = 35.8 bits (81), Expect = 0.051
 Identities = 24/77 (31%), Positives = 31/77 (40%)

Query: 224 SLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAF 283
           SL    KGH   V  + FS +   LAS      + VW            G  D      F
Sbjct: 10  SLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNF 69

Query: 284 TPDGKILVSGAADQTRR 300
           +P G +L SG+ D+T R
Sbjct: 70  SPSGHLLASGSRDKTVR 86


>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
          Length = 485

 Score =  125 bits (315), Expect = 4e-29
 Identities = 96/326 (29%), Positives = 145/326 (44%), Gaps = 48/326 (14%)

Query: 20  HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
           H   V S AFSP G+ L +GS D  V  W+  +    +   GH   V    +SPDG   A
Sbjct: 113 HSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLA 172

Query: 80  SASCDCTVRLWDVARAKCL-RVLKGHQR-----SVETVSFSPDSRQLASGGWDKRVMLWD 133
           S   +  + LWD +  K + R L GH +     S E +  +P+ R +AS   D  V +WD
Sbjct: 173 SGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWD 232

Query: 134 VQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIW------------------- 174
             +G+  R+L GH  S+    +      L + S D T+ +W                   
Sbjct: 233 TTAGRCERILTGHTQSVTCLRWGGD-GLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVN 291

Query: 175 ------DLRMVTPA-------VSHQALEGHSANISCLCYSASGL--------LASGSWDK 213
                 D  + T A       V+ Q L+G    +     S   L        L SGS D 
Sbjct: 292 TMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDF 351

Query: 214 TIHIWKPTTSSL-LIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLK 272
           T+ +W P      L ++ GH   +  + FSPD   +ASA + + +K+WD  TGK L +L+
Sbjct: 352 TLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLR 411

Query: 273 GVLDVAHTCAFTPDGKILVSGAADQT 298
           G +   +  A++ D ++LVSG++D T
Sbjct: 412 GHVAAVYQIAWSADSRLLVSGSSDST 437



 Score =  120 bits (301), Expect = 2e-27
 Identities = 72/192 (37%), Positives = 103/192 (53%), Gaps = 9/192 (4%)

Query: 59  LGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSR 118
           L GH+  V    FSP G   AS S D TVR WD++        KGH+  V ++S+SPD R
Sbjct: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGR 169

Query: 119 QLASGGWDKRVMLWDVQSG-QMLRLLVGHRDSIQSSDF-----SPTVNCLATGSWDSTVH 172
           +LASG  + +++LWD  +G Q+ R L GH   I    +     +P    +A+ S D +V 
Sbjct: 170 KLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVR 229

Query: 173 IWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGH 232
           IWD    T     + L GH+ +++CL +   GLL S S D+TI +W+     L   L+GH
Sbjct: 230 IWD---TTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGH 286

Query: 233 VTWVKSIAFSPD 244
             WV ++A S D
Sbjct: 287 GHWVNTMALSTD 298



 Score =  120 bits (301), Expect = 2e-27
 Identities = 96/333 (28%), Positives = 151/333 (45%), Gaps = 58/333 (17%)

Query: 20  HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWR-LGGHTGPVKFCRF-----SP 73
           H   V S ++SPDG+ L +G ++G +  W+  +G+ + R L GH+  +    +     +P
Sbjct: 155 HRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANP 214

Query: 74  DGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 133
           +    AS+S D +VR+WD    +C R+L GH +SV  + +  D   L S   D+ + +W 
Sbjct: 215 ECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGL-LYSASQDRTIKVWR 273

Query: 134 VQSGQMLRLLVGHRD-----------SIQSSDFSP---TVNC------------------ 161
              G + R L GH             ++++  F P   +VN                   
Sbjct: 274 AHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRY 333

Query: 162 ----------LATGSWDSTVHIWDLRMVTPAVSHQALE---GHSANISCLCYSA-SGLLA 207
                     L +GS D T+ +W     +PA   + L    GH A I+ + +S  S ++A
Sbjct: 334 NLVRGQGPERLVSGSDDFTLFLW-----SPAEDKKPLTRMTGHQALINQVLFSPDSRIVA 388

Query: 208 SGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKC 267
           S S+DK+I +W   T   L  L+GHV  V  IA+S D   L S      +KVWD    K 
Sbjct: 389 SASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKL 448

Query: 268 LETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
              L G  D  +   ++PDG+ + SG  D+  R
Sbjct: 449 AMDLPGHADEVYAVDWSPDGQRVASGGKDKCLR 481



 Score =  103 bits (256), Expect = 3e-22
 Identities = 78/275 (28%), Positives = 121/275 (44%), Gaps = 48/275 (17%)

Query: 30  SPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRL 89
           +P+ + + + S+DG V  W+T +G+    L GHT  V   R+  DG L+ SAS D T+++
Sbjct: 213 NPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLY-SASQDRTIKV 271

Query: 90  WDVARAKCLRVLKGHQRSVETVSFSPD--------------------------------- 116
           W        R L+GH   V T++ S D                                 
Sbjct: 272 WRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALS 331

Query: 117 ---------SRQLASGGWDKRVMLWD-VQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGS 166
                      +L SG  D  + LW   +  + L  + GH+  I    FSP    +A+ S
Sbjct: 332 RYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASAS 391

Query: 167 WDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSA-SGLLASGSWDKTIHIWKPTTSSL 225
           +D ++ +WD R      S   L GH A +  + +SA S LL SGS D T+ +W      L
Sbjct: 392 FDKSIKLWDGRTGKYLAS---LRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKL 448

Query: 226 LIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVW 260
            + L GH   V ++ +SPD   +AS G  + +++W
Sbjct: 449 AMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483



 Score = 86.7 bits (213), Expect = 3e-17
 Identities = 53/142 (37%), Positives = 78/142 (54%), Gaps = 5/142 (3%)

Query: 80  SASCDCTVRLWDVAR-AKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQ 138
           S S D T+ LW  A   K L  + GHQ  +  V FSPDSR +AS  +DK + LWD ++G+
Sbjct: 346 SGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGK 405

Query: 139 MLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCL 198
            L  L GH  ++    +S     L +GS DST+ +WD++    A+    L GH+  +  +
Sbjct: 406 YLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMD---LPGHADEVYAV 462

Query: 199 CYSASG-LLASGSWDKTIHIWK 219
            +S  G  +ASG  DK + IW+
Sbjct: 463 DWSPDGQRVASGGKDKCLRIWR 484



 Score = 84.3 bits (207), Expect = 1e-16
 Identities = 64/203 (31%), Positives = 91/203 (44%), Gaps = 15/203 (7%)

Query: 93  ARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQS 152
           A  +C   L+GH  +V +V+FSP  + LASG  D  V  WD+ +        GHR  + S
Sbjct: 102 AVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLS 161

Query: 153 SDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQ---ALEGHSANISCLCYS------AS 203
             +SP    LA+G  +  + +WD     P+   Q    L GHS  I+ L +         
Sbjct: 162 ISWSPDGRKLASGCKNGQILLWD-----PSTGKQVGRTLAGHSKWITGLSWEPLHANPEC 216

Query: 204 GLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCN 263
             +AS S D ++ IW  T       L GH   V  + +  D L L SA   R +KVW  +
Sbjct: 217 RYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGL-LYSASQDRTIKVWRAH 275

Query: 264 TGKCLETLKGVLDVAHTCAFTPD 286
            G    TL+G     +T A + D
Sbjct: 276 DGVLCRTLQGHGHWVNTMALSTD 298



 Score = 82.4 bits (202), Expect = 5e-16
 Identities = 42/113 (37%), Positives = 61/113 (53%)

Query: 20  HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
           H   +N   FSPD +++ + S D  +  W+ R+G+ L  L GH   V    +S D  L  
Sbjct: 371 HQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLV 430

Query: 80  SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLW 132
           S S D T+++WDV   K    L GH   V  V +SPD +++ASGG DK + +W
Sbjct: 431 SGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483



 Score = 44.3 bits (103), Expect = 1e-04
 Identities = 29/85 (34%), Positives = 42/85 (49%), Gaps = 8/85 (9%)

Query: 229 LKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGK 288
           L+GH   V S+AFSP   +LAS      V+ WD +T     T KG      + +++PDG+
Sbjct: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGR 169

Query: 289 ILVSGAAD--------QTRRQISRT 305
            L SG  +         T +Q+ RT
Sbjct: 170 KLASGCKNGQILLWDPSTGKQVGRT 194



 Score = 32.7 bits (73), Expect = 0.43
 Identities = 15/44 (34%), Positives = 26/44 (59%)

Query: 266 KCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRRQISRTSKSP 309
           +C  +L+G  +   + AF+P GK L SG+ D T R    ++++P
Sbjct: 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETP 148


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score =  125 bits (313), Expect = 6e-29
 Identities = 88/258 (34%), Positives = 118/258 (45%), Gaps = 15/258 (5%)

Query: 12  RRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGW--ETRSGQLLWRLGGHTGPVKFC 69
           R  +F G H   V    FSP G +L +GS D  V  W    +    ++R   HT  V+  
Sbjct: 15  RAYRFTG-HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFR--AHTATVRSV 71

Query: 70  RFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRV 129
            F  DG  F +AS D TV++W   R K L  L  H   V    FSPD R + S   DK V
Sbjct: 72  HFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTV 131

Query: 130 MLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALE 189
            LWD  S + +     H   +   DF P+  C+A    D+TV +WD+R      +H+ L+
Sbjct: 132 KLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR------THRLLQ 185

Query: 190 G---HSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDE 245
               HSA ++ L +  SG  L + S D T+ I       LL  L GH     ++AFS   
Sbjct: 186 HYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTG 245

Query: 246 LWLASAGYSRMVKVWDCN 263
            + AS G    V VW  N
Sbjct: 246 EYFASGGSDEQVMVWKSN 263



 Score =  116 bits (290), Expect = 3e-26
 Identities = 76/257 (29%), Positives = 115/257 (44%), Gaps = 4/257 (1%)

Query: 42  DGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVL 101
           D C+  W  +     +R  GH   V    FSP GHL AS S D TVR+W         V 
Sbjct: 2   DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61

Query: 102 KGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNC 161
           + H  +V +V F  D +   +   DK V +W     + L  L  H + ++ + FSP    
Sbjct: 62  RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121

Query: 162 LATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGL-LASGSWDKTIHIWKP 220
           + + S D TV +WD    +    H   E H   ++ + +  SG  +A+   D T+ +W  
Sbjct: 122 IVSASDDKTVKLWDKS--SRECVHSYCE-HGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 178

Query: 221 TTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHT 280
            T  LL   + H   V  ++F P   +L +A     +K+ D   G+ L TL G    A T
Sbjct: 179 RTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATT 238

Query: 281 CAFTPDGKILVSGAADQ 297
            AF+  G+   SG +D+
Sbjct: 239 VAFSRTGEYFASGGSDE 255



 Score = 85.9 bits (211), Expect = 4e-17
 Identities = 59/216 (27%), Positives = 92/216 (42%), Gaps = 4/216 (1%)

Query: 84  DCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLL 143
           D  + +W +          GH+ +V  V+FSP    LASG  DK V +W         + 
Sbjct: 2   DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61

Query: 144 VGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSAS 203
             H  +++S  F        T S D TV +W         S   L  H   + C  +S  
Sbjct: 62  RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFS---LSQHINWVRCAKFSPD 118

Query: 204 G-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDC 262
           G L+ S S DKT+ +W  ++   +     H  +V  + F P    +A+AG    VKVWD 
Sbjct: 119 GRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 178

Query: 263 NTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQT 298
            T + L+  +      +  +F P G  L++ ++D T
Sbjct: 179 RTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDST 214



 Score = 77.0 bits (188), Expect = 2e-14
 Identities = 44/141 (31%), Positives = 72/141 (51%), Gaps = 4/141 (2%)

Query: 168 DSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLL 226
           DS + +W ++   P        GH   ++C+ +S SG LLASGS DKT+ IW P      
Sbjct: 2   DSCLMVWHMK---PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGES 58

Query: 227 IQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPD 286
              + H   V+S+ F  D     +A   + VKVW  +  K L +L   ++      F+PD
Sbjct: 59  TVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPD 118

Query: 287 GKILVSGAADQTRRQISRTSK 307
           G+++VS + D+T +   ++S+
Sbjct: 119 GRLIVSASDDKTVKLWDKSSR 139


>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
          Length = 357

 Score =  123 bits (309), Expect = 2e-28
 Identities = 72/239 (30%), Positives = 122/239 (51%), Gaps = 8/239 (3%)

Query: 20  HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDG-HLF 78
           H G V    ++ DG ML + S D  V  W++ +G+ + RL GHT  V  C  +  G  L 
Sbjct: 108 HSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLV 167

Query: 79  ASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQ 138
            + S D TV+LWD+ +   ++  +   + V  V+F+  S Q+ SGG D  + +WD++  +
Sbjct: 168 CTGSDDGTVKLWDIRKKAAIQTFQNTYQ-VLAVTFNDTSDQIISGGIDNDIKVWDLRQNK 226

Query: 139 MLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTP-----AVSHQALEGHSA 193
           +   + GH DS+     S   + L + + D+TV +WD+R   P      +    +     
Sbjct: 227 LTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEK 286

Query: 194 NISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASA 251
           N+    +S  G  +A+GS D+ +++W  T+  +L +L GH   +  +AF PDE  + SA
Sbjct: 287 NLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISA 345



 Score =  110 bits (274), Expect = 2e-24
 Identities = 72/251 (28%), Positives = 117/251 (46%), Gaps = 17/251 (6%)

Query: 59  LGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDV-ARAKCLRVLKGHQRSVETVSFSPDS 117
           L GH G V  C+F P+G   ASA  D  + LW+V         LKGH  +V  + ++ D 
Sbjct: 62  LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDG 121

Query: 118 RQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQS---SDFSPTVNCLATGSWDSTVHIW 174
             L S   DK V +WD ++G+ ++ L GH   + S   +   P + C  TGS D TV +W
Sbjct: 122 SMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVC--TGSDDGTVKLW 179

Query: 175 DLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVT 234
           D+R      + Q  +     ++      S  + SG  D  I +W    + L   ++GH  
Sbjct: 180 DIR---KKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHAD 236

Query: 235 WVKSIAFSPDELWLASAGYSRMVKVWDCN----TGKCLETLKGVLDVAH----TCAFTPD 286
            V  ++ S +  +L S      V+VWD        +C++  +G +         C+++PD
Sbjct: 237 SVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPD 296

Query: 287 GKILVSGAADQ 297
           G  + +G+AD+
Sbjct: 297 GSKIAAGSADR 307



 Score = 83.2 bits (204), Expect = 3e-16
 Identities = 57/207 (27%), Positives = 95/207 (45%), Gaps = 9/207 (4%)

Query: 98  LRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSG-QMLRLLVGHRDSIQSSDFS 156
           + +L GH+  V    F P+   LAS G+D+ ++LW+V         L GH  ++    ++
Sbjct: 59  IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYN 118

Query: 157 PTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG---LLASGSWDK 213
              + L + S D TV +WD          + L+GH++ ++  CY A     L+ +GS D 
Sbjct: 119 TDGSMLFSASTDKTVAVWDSETGERV---KRLKGHTSFVNS-CYPARRGPQLVCTGSDDG 174

Query: 214 TIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKG 273
           T+ +W        IQ   +   V ++ F+     + S G    +KVWD    K   T++G
Sbjct: 175 TVKLWD-IRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRG 233

Query: 274 VLDVAHTCAFTPDGKILVSGAADQTRR 300
             D     + + +G  L+S A D T R
Sbjct: 234 HADSVTGLSLSSEGSYLLSNAMDNTVR 260



 Score = 79.3 bits (194), Expect = 4e-15
 Identities = 45/167 (26%), Positives = 84/167 (50%), Gaps = 8/167 (4%)

Query: 19  QHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLF 78
           Q+  +V +  F+     +++G  D  +  W+ R  +L + + GH   V     S +G   
Sbjct: 191 QNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYL 250

Query: 79  ASASCDCTVRLWDVA----RAKCLRVLKGHQRSVET----VSFSPDSRQLASGGWDKRVM 130
            S + D TVR+WDV     + +C+++ +G+  + E      S+SPD  ++A+G  D+ V 
Sbjct: 251 LSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVY 310

Query: 131 LWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLR 177
           +WD  S ++L  L GH  SI    F P    + + S D  +++ +++
Sbjct: 311 VWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357



 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 31/77 (40%), Positives = 41/77 (53%), Gaps = 4/77 (5%)

Query: 12  RRVKFF--GQHGGEVN--SSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVK 67
           R VK F    H  E N    ++SPDG  +  GS D  VY W+T S ++L++L GH G + 
Sbjct: 272 RCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSIN 331

Query: 68  FCRFSPDGHLFASASCD 84
              F PD  +  SAS D
Sbjct: 332 EVAFHPDEPIIISASSD 348


>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
           [Homo sapiens]
          Length = 514

 Score =  122 bits (307), Expect = 3e-28
 Identities = 79/241 (32%), Positives = 117/241 (48%), Gaps = 6/241 (2%)

Query: 59  LGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSR 118
           + GH G V+     P    F + S D T+++WD+A  K    L GH  +V  V  S  S 
Sbjct: 200 ISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSP 259

Query: 119 QLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRM 178
            L S G DK+V  WD++  +++R   GH  ++   D  PT++ L T S DST  IWD+R 
Sbjct: 260 YLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVR- 318

Query: 179 VTPAVSHQALEGHSANISCL-CYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVK 237
            T A  H  L GH+  ++ + C +A   + +GS D TI +W        + L  H   V+
Sbjct: 319 -TKASVH-TLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVR 376

Query: 238 SIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQ 297
           ++   P     AS G    +K W    G  ++ L G   + +T     DG +LVSGA + 
Sbjct: 377 AVVLHPRHYTFAS-GSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDG-VLVSGADNG 434

Query: 298 T 298
           T
Sbjct: 435 T 435



 Score = 95.1 bits (235), Expect = 7e-20
 Identities = 77/288 (26%), Positives = 120/288 (41%), Gaps = 14/288 (4%)

Query: 20  HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
           H G V   A  P  Q  +TGS D  +  W+  SG+L   L GH   V+    S       
Sbjct: 203 HLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLF 262

Query: 80  SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
           S   D  V+ WD+   K +R   GH  +V  +   P    L +   D    +WDV++   
Sbjct: 263 SCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKAS 322

Query: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANI-SCL 198
           +  L GH +++ +         + TGS D+T+ +WDL       +   L  H  ++ + +
Sbjct: 323 VHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDL---VAGKTRVTLTNHKKSVRAVV 379

Query: 199 CYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVK 258
            +      ASGS D  I  WK    S +  L GH   + ++  + D + ++ A    M  
Sbjct: 380 LHPRHYTFASGSPD-NIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTM-H 437

Query: 259 VWDCNTGKCLETL-----KGVLDV---AHTCAFTPDGKILVSGAADQT 298
           +WD  TG   + +      G LD       CAF      L++  AD+T
Sbjct: 438 LWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKT 485



 Score = 79.7 bits (195), Expect = 3e-15
 Identities = 60/215 (27%), Positives = 90/215 (41%), Gaps = 14/215 (6%)

Query: 14  VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSP 73
           ++ +  H   V      P   +L+T S D     W+ R+   +  L GHT  V   R   
Sbjct: 281 IRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQA 340

Query: 74  DGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 133
                 + S D T+RLWD+   K    L  H++SV  V   P     ASG  D  +  W 
Sbjct: 341 AEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPD-NIKQWK 399

Query: 134 VQSGQMLRLLVGHRDSIQSSDFSPTVN---CLATGSWDSTVHIWDLR------MVTPAVS 184
              G  ++ L GH   I +     TVN    L +G+ + T+H+WD R       V  AV 
Sbjct: 400 FPDGSFIQNLSGHNAIINTL----TVNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQ 455

Query: 185 HQALEGHSANISCLCYSASGLLASGSWDKTIHIWK 219
             +L+  S   +C    +   L +   DKTI +++
Sbjct: 456 PGSLDSESGIFACAFDQSESRLLTAEADKTIKVYR 490



 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 32/117 (27%), Positives = 52/117 (44%), Gaps = 1/117 (0%)

Query: 185 HQALEGHSANISCLCYSASGL-LASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSP 243
           ++ + GH   + C+          +GS D+TI IW   +  L + L GH++ V+ +  S 
Sbjct: 197 YRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVST 256

Query: 244 DELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
              +L S G  + VK WD    K +    G L   +     P   +LV+ + D T R
Sbjct: 257 RSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTAR 313


>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
           sapiens]
          Length = 472

 Score =  122 bits (306), Expect = 4e-28
 Identities = 73/238 (30%), Positives = 121/238 (50%), Gaps = 10/238 (4%)

Query: 32  DGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASA-SCDCTVRLW 90
           D   ++  S D  V  W+  +G+LLW++   T  V  C+FSPDG    S    D  + + 
Sbjct: 156 DSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVS-CKFSPDGKYVVSGFDVDHGICIM 214

Query: 91  DVARAKCLRVLKGHQ-RSVETVSFSPDSRQLASGGWDKRVMLWDVQS-GQMLRLLVGHRD 148
           D      + V+K H  RS+ +  F PDS+++AS   D+ + +WDV S   +L +   H +
Sbjct: 215 DAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSN 274

Query: 149 SIQSSDFSPTVNCLATGSWDSTVHIWDLR---MVTPAVSHQALEGHSANISCLCYSA--S 203
           +I +  F+ + + L T SWD  + IW++              ++GH  ++S  C+ A  S
Sbjct: 275 AISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSS-CHFARDS 333

Query: 204 GLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWD 261
             L SG +D+T+ IW        + LKGH  WV  +A S ++ W+ SA   R +++W+
Sbjct: 334 SFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWN 391



 Score =  110 bits (274), Expect = 2e-24
 Identities = 87/296 (29%), Positives = 134/296 (45%), Gaps = 13/296 (4%)

Query: 15  KFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHT-GPVKFCRFSP 73
           K    H   V++  F  D   LL+GS D  V  W+   G ++         PV  C  + 
Sbjct: 96  KILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITG 155

Query: 74  DGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASG-GWDKRVMLW 132
           D     +AS D TVR WD+   K L  ++ +   + +  FSPD + + SG   D  + + 
Sbjct: 156 DSSRVIAASYDKTVRAWDLETGKLLWKVR-YDTFIVSCKFSPDGKYVVSGFDVDHGICIM 214

Query: 133 DVQSGQMLRLLVGHRD-SIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGH 191
           D ++   + ++  H   SI S  F P    +A+ S D  + IWD+   + A      + H
Sbjct: 215 DAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDV--TSQATLLTITKAH 272

Query: 192 SANISCLCYSASG-LLASGSWDKTIHIWKPTTSSL------LIQLKGHVTWVKSIAFSPD 244
           S  IS  C++ SG  L + SWDK + IW   T         +  ++GH   V S  F+ D
Sbjct: 273 SNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARD 332

Query: 245 ELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
             +L S G+ R V +WD   G    +LKG  D     A + + K ++S + D+T R
Sbjct: 333 SSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMR 388



 Score = 92.4 bits (228), Expect = 5e-19
 Identities = 49/167 (29%), Positives = 82/167 (49%), Gaps = 7/167 (4%)

Query: 20  HGGEVNSSAFSPDGQMLLTGSEDGCVYGWE-TRSGQLLWRLGGHTGPVKFCRFSPDGHLF 78
           H   + S  F PD Q + + S D C+  W+ T    LL     H+  +  C F+  GH  
Sbjct: 229 HTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFL 288

Query: 79  ASASCDCTVRLWDVARAK------CLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLW 132
            ++S D  +++W+V   +      C+ +++GH+ SV +  F+ DS  L SGG+D+ V +W
Sbjct: 289 CTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIW 348

Query: 133 DVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMV 179
           DV  G     L GH D +     S     + + S D T+ +W++  +
Sbjct: 349 DVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIEEI 395



 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 36/137 (26%), Positives = 63/137 (45%), Gaps = 6/137 (4%)

Query: 20  HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQL------LWRLGGHTGPVKFCRFSP 73
           H   +++  F+  G  L T S D  +  W   +G+       +  + GH G V  C F+ 
Sbjct: 272 HSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFAR 331

Query: 74  DGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 133
           D     S   D TV +WDVA       LKGH   V  V+ S + + + S   D+ + LW+
Sbjct: 332 DSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWN 391

Query: 134 VQSGQMLRLLVGHRDSI 150
           ++    + L++ ++ ++
Sbjct: 392 IEEIDEIPLVIKYKKAV 408


>gi|13376840 WD repeat domain 61 [Homo sapiens]
          Length = 305

 Score =  122 bits (305), Expect = 5e-28
 Identities = 88/269 (32%), Positives = 134/269 (49%), Gaps = 6/269 (2%)

Query: 32  DGQMLLTGSEDGCVYGWETRSGQL--LWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRL 89
           + + ++TGS D  V  W+ R  +L   W L GH   V     S    + AS+S D  +RL
Sbjct: 31  NSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRL 90

Query: 90  WDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDS 149
           WD+   K ++ +        T++FSPDS+ LA+G    +V ++ V+SG+    L      
Sbjct: 91  WDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKF 150

Query: 150 IQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSA-SGLLAS 208
           I S  +SP    LA+G+ D  ++I+D+   T  + H  LEGH+  I  L +S  S LL +
Sbjct: 151 ILSIAYSPDGKYLASGAIDGIINIFDI--ATGKLLH-TLEGHAMPIRSLTFSPDSQLLVT 207

Query: 209 GSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCL 268
            S D  I I+    ++L   L GH +WV ++AF PD+    S+   + VKVWD  T  C+
Sbjct: 208 ASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCV 267

Query: 269 ETLKGVLDVAHTCAFTPDGKILVSGAADQ 297
            T     D      +  +G  +VS   DQ
Sbjct: 268 HTFFDHQDQVWGVKYNGNGSKIVSVGDDQ 296



 Score = 95.9 bits (237), Expect = 4e-20
 Identities = 54/176 (30%), Positives = 86/176 (48%), Gaps = 11/176 (6%)

Query: 11  VRRVKFFGQHGGE-----------VNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRL 59
           V +V  FG   G+           + S A+SPDG+ L +G+ DG +  ++  +G+LL  L
Sbjct: 127 VGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTL 186

Query: 60  GGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQ 119
            GH  P++   FSPD  L  +AS D  ++++DV  A     L GH   V  V+F PD   
Sbjct: 187 EGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTH 246

Query: 120 LASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWD 175
             S   DK V +WDV +   +     H+D +    ++   + + +   D  +HI+D
Sbjct: 247 FVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302



 Score = 90.1 bits (222), Expect = 2e-18
 Identities = 58/192 (30%), Positives = 94/192 (48%), Gaps = 4/192 (2%)

Query: 28  AFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTV 87
           AFSPD Q L TG+  G V  +   SG+  + L      +    +SPDG   AS + D  +
Sbjct: 113 AFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGII 172

Query: 88  RLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHR 147
            ++D+A  K L  L+GH   + +++FSPDS+ L +   D  + ++DVQ   +   L GH 
Sbjct: 173 NIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHA 232

Query: 148 DSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG-LL 206
             + +  F P      + S D +V +WD+   T    H   + H   +  + Y+ +G  +
Sbjct: 233 SWVLNVAFCPDDTHFVSSSSDKSVKVWDVG--TRTCVHTFFD-HQDQVWGVKYNGNGSKI 289

Query: 207 ASGSWDKTIHIW 218
            S   D+ IHI+
Sbjct: 290 VSVGDDQEIHIY 301



 Score = 87.4 bits (215), Expect = 1e-17
 Identities = 66/222 (29%), Positives = 101/222 (45%), Gaps = 6/222 (2%)

Query: 80  SASCDCTVRLWDVA--RAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSG 137
           + S D  V++W     R      L+GHQ  V +V  S      AS   D  + LWD+++G
Sbjct: 37  TGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENG 96

Query: 138 QMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISC 197
           + ++ +        +  FSP    LATG+    V+I+    V       +L+     I  
Sbjct: 97  KQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFG---VESGKKEYSLDTRGKFILS 153

Query: 198 LCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRM 256
           + YS  G  LASG+ D  I+I+   T  LL  L+GH   ++S+ FSPD   L +A     
Sbjct: 154 IAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGY 213

Query: 257 VKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQT 298
           +K++D        TL G        AF PD    VS ++D++
Sbjct: 214 IKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKS 255


>gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo
           sapiens]
          Length = 275

 Score =  120 bits (300), Expect = 2e-27
 Identities = 85/250 (34%), Positives = 123/250 (49%), Gaps = 35/250 (14%)

Query: 49  ETRSGQLLWRLGGHTGPVKFCRFSPDGHLF-ASASCDCTVRLWDVAR-AKCLRVLKGHQR 106
           E   G+LL  L  HT  V+   F+PDG L   SAS D T+R+WD+      ++VL+GHQ 
Sbjct: 10  EKEIGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQN 69

Query: 107 SVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGS 166
            V + +FSPDS  L S G  K V LW++    M+R L GH   + + DFSP    LAT S
Sbjct: 70  WVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATAS 129

Query: 167 WDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLL 226
           +D+ V+IWD               H+ +I         L+  G      H++ P T   +
Sbjct: 130 YDTRVYIWD--------------PHNGDI---------LMEFG------HLFPPPTP--I 158

Query: 227 IQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPD 286
                +  WV+S++FS D L +AS    +MV+ W  +    ++     L     CAF+ D
Sbjct: 159 FAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQV--APLSNGLCCAFSTD 216

Query: 287 GKILVSGAAD 296
           G +L +G  D
Sbjct: 217 GSVLAAGTHD 226



 Score = 76.3 bits (186), Expect = 3e-14
 Identities = 58/186 (31%), Positives = 78/186 (41%), Gaps = 17/186 (9%)

Query: 14  VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSP 73
           +K    H   V S AFSPD  ML +      V+ W      ++ +L GH   V  C FSP
Sbjct: 61  MKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSP 120

Query: 74  DGHLFASASCDCTVRLWDVARAKCLRVLKGH--------------QRSVETVSFSPDSRQ 119
           DG L A+AS D  V +WD      L    GH               R V +VSFS D   
Sbjct: 121 DGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLH 179

Query: 120 LASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMV 179
           +AS   DK V  W +     ++  V    +     FS   + LA G+ D +V+ W     
Sbjct: 180 VASLADDKMVRFWRIDEDYPVQ--VAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQ 237

Query: 180 TPAVSH 185
            P++ H
Sbjct: 238 VPSLQH 243



 Score = 68.6 bits (166), Expect = 7e-12
 Identities = 50/169 (29%), Positives = 79/169 (46%), Gaps = 12/169 (7%)

Query: 137 GQMLRLLVGHRDSIQSSDFSPTVNC-LATGSWDSTVHIWDLRMVTPAVSHQALEGHSANI 195
           G++L  LV H + ++   F+P  +  L + S D T+ +WDL+        + L GH   +
Sbjct: 14  GKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLK--DDGNMMKVLRGHQNWV 71

Query: 196 -SCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYS 254
            SC     S +L S    K + +W     +++ +L+GH   V +  FSPD   LA+A Y 
Sbjct: 72  YSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYD 131

Query: 255 RMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRRQIS 303
             V +WD + G  L      ++  H   F P   I   GA D+  R +S
Sbjct: 132 TRVYIWDPHNGDIL------MEFGH--LFPPPTPIFAGGANDRWVRSVS 172


>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
          Length = 631

 Score =  119 bits (299), Expect = 3e-27
 Identities = 86/296 (29%), Positives = 135/296 (45%), Gaps = 5/296 (1%)

Query: 6   PATLAVRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGP 65
           PA    +    F  H   V+  +  P   +L++  ED            +L    GHT  
Sbjct: 337 PAKFDYKLKNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDW 396

Query: 66  VKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGW 125
           +  C F P G   A++S D TV+LWD+ +  C+   +GH R+V + ++      +AS   
Sbjct: 397 LSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSL 456

Query: 126 DKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSH 185
           DK   +WDV S +    L GH DS+ S +F P  N L T S D T+ IWD R     +  
Sbjct: 457 DKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDAR---TGICE 513

Query: 186 QALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPD 244
           Q+L GH  +I+   +   G ++AS        +W       ++ +    +    + F   
Sbjct: 514 QSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSS 573

Query: 245 ELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
              LA A  + ++ + D  +G+ +  L G  + AHT  F+ DG+IL SG +D T R
Sbjct: 574 GRVLAQASGNGVIHLLDLKSGE-IHKLMGHENEAHTVVFSHDGEILFSGGSDGTVR 628



 Score =  109 bits (272), Expect = 4e-24
 Identities = 73/241 (30%), Positives = 107/241 (44%), Gaps = 3/241 (1%)

Query: 20  HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
           H   ++   F P G  L T S D  V  W+   G  +    GH+  V  C +   G+  A
Sbjct: 393 HTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVA 452

Query: 80  SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
           S+S D T ++WDV   +C   L GH  SV ++ F P S  L +   DK + +WD ++G  
Sbjct: 453 SSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGIC 512

Query: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLC 199
            + L GH  SI  + F P  + +A+        +WD R + P VS     G S       
Sbjct: 513 EQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDI--GPSPGNEVNF 570

Query: 200 YSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKV 259
            S+  +LA  S +  IH+     S  + +L GH     ++ FS D   L S G    V+ 
Sbjct: 571 DSSGRVLAQASGNGVIHL-LDLKSGEIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRT 629

Query: 260 W 260
           W
Sbjct: 630 W 630


>gi|189571685 WD repeat, sterile alpha motif and U-box domain
           containing 1 [Homo sapiens]
          Length = 476

 Score =  119 bits (299), Expect = 3e-27
 Identities = 100/309 (32%), Positives = 138/309 (44%), Gaps = 27/309 (8%)

Query: 11  VRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWR--LGGHTGPVKF 68
           V+ +     HG +VN  AFS    +L T S D  +  +  R    L    L  HT  V  
Sbjct: 2   VKLIHTLADHGDDVNCCAFS--FSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHC 59

Query: 69  CRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRS-VETVSFSPDSRQLASGGWDK 127
           C FSP GH+ AS S D T  LW+    + L V++    S V    FSPDS  LASG  D 
Sbjct: 60  CCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADG 119

Query: 128 RVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQA 187
            V+LW+ QS ++ R       S+ +  FSP  +   TGS    + +WD +M      H  
Sbjct: 120 TVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM---RCLHSE 176

Query: 188 LEGHSANISCLCYSASGL-----------LASGSWDKTIHIWKPTTSSLL-------IQL 229
            + H   I+C  +S+  +           LAS   D  + IW  + + +L         L
Sbjct: 177 -KAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTL 235

Query: 230 KGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKI 289
            GH   V + AFS D   L S    + V V+D NT   L TL        TCAF P+  +
Sbjct: 236 SGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLL 295

Query: 290 LVSGAADQT 298
           L +G+ D+T
Sbjct: 296 LATGSMDKT 304



 Score =  101 bits (251), Expect = 1e-21
 Identities = 80/268 (29%), Positives = 118/268 (44%), Gaps = 21/268 (7%)

Query: 20  HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTG-PVKFCRFSPDGHLF 78
           H   V+   FSP G +L + S DG    W T +GQ+L  +   +G PV+ C+FSPD    
Sbjct: 53  HTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCL 112

Query: 79  ASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQ 138
           AS + D TV LW+    K  R       S+   +FSP+     +G     + +WD +  +
Sbjct: 113 ASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM-R 171

Query: 139 MLRLLVGHRDSIQSSDFSPTVNC----------LATGSWDSTVHIWDLRMVT----PAVS 184
            L     H   I   DFS               LA+   D  V IW +            
Sbjct: 172 CLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKY 231

Query: 185 HQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSP 243
              L GH A +    +S  G +L SGS DK++ ++   T ++L  L  H  +V + AF+P
Sbjct: 232 KSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAP 291

Query: 244 DELWLASAGYSRMVKVWDCNTGKCLETL 271
           + L LA+    + V +W  +    LETL
Sbjct: 292 NTLLLATGSMDKTVNIWQFD----LETL 315


>gi|189571683 WD repeat, sterile alpha motif and U-box domain
           containing 1 [Homo sapiens]
          Length = 476

 Score =  119 bits (299), Expect = 3e-27
 Identities = 100/309 (32%), Positives = 138/309 (44%), Gaps = 27/309 (8%)

Query: 11  VRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWR--LGGHTGPVKF 68
           V+ +     HG +VN  AFS    +L T S D  +  +  R    L    L  HT  V  
Sbjct: 2   VKLIHTLADHGDDVNCCAFS--FSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHC 59

Query: 69  CRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRS-VETVSFSPDSRQLASGGWDK 127
           C FSP GH+ AS S D T  LW+    + L V++    S V    FSPDS  LASG  D 
Sbjct: 60  CCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADG 119

Query: 128 RVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQA 187
            V+LW+ QS ++ R       S+ +  FSP  +   TGS    + +WD +M      H  
Sbjct: 120 TVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM---RCLHSE 176

Query: 188 LEGHSANISCLCYSASGL-----------LASGSWDKTIHIWKPTTSSLL-------IQL 229
            + H   I+C  +S+  +           LAS   D  + IW  + + +L         L
Sbjct: 177 -KAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTL 235

Query: 230 KGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKI 289
            GH   V + AFS D   L S    + V V+D NT   L TL        TCAF P+  +
Sbjct: 236 SGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLL 295

Query: 290 LVSGAADQT 298
           L +G+ D+T
Sbjct: 296 LATGSMDKT 304



 Score =  101 bits (251), Expect = 1e-21
 Identities = 80/268 (29%), Positives = 118/268 (44%), Gaps = 21/268 (7%)

Query: 20  HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTG-PVKFCRFSPDGHLF 78
           H   V+   FSP G +L + S DG    W T +GQ+L  +   +G PV+ C+FSPD    
Sbjct: 53  HTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCL 112

Query: 79  ASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQ 138
           AS + D TV LW+    K  R       S+   +FSP+     +G     + +WD +  +
Sbjct: 113 ASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM-R 171

Query: 139 MLRLLVGHRDSIQSSDFSPTVNC----------LATGSWDSTVHIWDLRMVT----PAVS 184
            L     H   I   DFS               LA+   D  V IW +            
Sbjct: 172 CLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKY 231

Query: 185 HQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSP 243
              L GH A +    +S  G +L SGS DK++ ++   T ++L  L  H  +V + AF+P
Sbjct: 232 KSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAP 291

Query: 244 DELWLASAGYSRMVKVWDCNTGKCLETL 271
           + L LA+    + V +W  +    LETL
Sbjct: 292 NTLLLATGSMDKTVNIWQFD----LETL 315


>gi|189571681 WD repeat, sterile alpha motif and U-box domain
           containing 1 [Homo sapiens]
          Length = 476

 Score =  119 bits (299), Expect = 3e-27
 Identities = 100/309 (32%), Positives = 138/309 (44%), Gaps = 27/309 (8%)

Query: 11  VRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWR--LGGHTGPVKF 68
           V+ +     HG +VN  AFS    +L T S D  +  +  R    L    L  HT  V  
Sbjct: 2   VKLIHTLADHGDDVNCCAFS--FSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHC 59

Query: 69  CRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRS-VETVSFSPDSRQLASGGWDK 127
           C FSP GH+ AS S D T  LW+    + L V++    S V    FSPDS  LASG  D 
Sbjct: 60  CCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADG 119

Query: 128 RVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQA 187
            V+LW+ QS ++ R       S+ +  FSP  +   TGS    + +WD +M      H  
Sbjct: 120 TVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM---RCLHSE 176

Query: 188 LEGHSANISCLCYSASGL-----------LASGSWDKTIHIWKPTTSSLL-------IQL 229
            + H   I+C  +S+  +           LAS   D  + IW  + + +L         L
Sbjct: 177 -KAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTL 235

Query: 230 KGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKI 289
            GH   V + AFS D   L S    + V V+D NT   L TL        TCAF P+  +
Sbjct: 236 SGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLL 295

Query: 290 LVSGAADQT 298
           L +G+ D+T
Sbjct: 296 LATGSMDKT 304



 Score =  101 bits (251), Expect = 1e-21
 Identities = 80/268 (29%), Positives = 118/268 (44%), Gaps = 21/268 (7%)

Query: 20  HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTG-PVKFCRFSPDGHLF 78
           H   V+   FSP G +L + S DG    W T +GQ+L  +   +G PV+ C+FSPD    
Sbjct: 53  HTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCL 112

Query: 79  ASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQ 138
           AS + D TV LW+    K  R       S+   +FSP+     +G     + +WD +  +
Sbjct: 113 ASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM-R 171

Query: 139 MLRLLVGHRDSIQSSDFSPTVNC----------LATGSWDSTVHIWDLRMVT----PAVS 184
            L     H   I   DFS               LA+   D  V IW +            
Sbjct: 172 CLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKY 231

Query: 185 HQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSP 243
              L GH A +    +S  G +L SGS DK++ ++   T ++L  L  H  +V + AF+P
Sbjct: 232 KSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAP 291

Query: 244 DELWLASAGYSRMVKVWDCNTGKCLETL 271
           + L LA+    + V +W  +    LETL
Sbjct: 292 NTLLLATGSMDKTVNIWQFD----LETL 315


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score =  119 bits (297), Expect = 5e-27
 Identities = 88/303 (29%), Positives = 138/303 (45%), Gaps = 16/303 (5%)

Query: 20  HGGEVNSSAFSP-DGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLF 78
           H   V+S       G++L TG +D  V  W       +  L GHT PV+  R +    L 
Sbjct: 19  HASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELI 78

Query: 79  ASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQ 138
            + S   ++R+WD+  AK LR L GH+ ++ ++ F P    +ASG  D  + LWD++   
Sbjct: 79  VAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKG 138

Query: 139 MLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCL 198
            +    GH  +++   FSP    LA+ + D TV +WDL   T         GH+  ++ +
Sbjct: 139 CVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDL---TAGKMMSEFPGHTGPVNVV 195

Query: 199 CYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMV 257
            +  +  LLASGS D+TI  W      ++  ++G    V+S+ F+PD   L S G    +
Sbjct: 196 EFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYS-GCQDSL 254

Query: 258 KVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILV--------SGAADQTRRQISRTSKSP 309
           +V+     +C + +          A   D  I V        S   D TR  ++RT    
Sbjct: 255 RVYGWEPERCFDVVLVNWGKVADLAICNDQLIGVAFSQSNVSSYVVDLTR--VTRTGTVA 312

Query: 310 RDP 312
           RDP
Sbjct: 313 RDP 315



 Score = 46.2 bits (108), Expect = 4e-05
 Identities = 26/85 (30%), Positives = 42/85 (49%), Gaps = 1/85 (1%)

Query: 17  FGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGH 76
           F  H G VN   F P+  +L +GS D  +  W+    Q++  + G  GPV+   F+PDG 
Sbjct: 185 FPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGC 244

Query: 77  LFASASCDCTVRLWDVARAKCLRVL 101
              S  C  ++R++     +C  V+
Sbjct: 245 CLYS-GCQDSLRVYGWEPERCFDVV 268


>gi|8923881 WD SOCS-box protein 2 [Homo sapiens]
          Length = 404

 Score =  118 bits (295), Expect = 8e-27
 Identities = 75/196 (38%), Positives = 107/196 (54%), Gaps = 12/196 (6%)

Query: 35  MLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLF-ASASCDCTVRLWDVA 93
           +L TG  DG +  WE ++G LL  L GH   V+   F+P G L   SAS D T+R+WD+ 
Sbjct: 125 VLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLN 184

Query: 94  R-AKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQS 152
           +  K ++VL GH + V   S SPD   L S   +K V LW ++S  ++R L GH+ S+ S
Sbjct: 185 KHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVS 244

Query: 153 SDFSPTVNCLATGSWDSTVHIWD------LRMVTPAVSHQALEGHSANISCL---CYSAS 203
            DFSP    L T S+D+ V +WD      LR +       A++    +IS L   C+S  
Sbjct: 245 CDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPE 304

Query: 204 GL-LASGSWDKTIHIW 218
           GL LA+ + D+ + IW
Sbjct: 305 GLYLATVADDRLLRIW 320



 Score = 93.2 bits (230), Expect = 3e-19
 Identities = 86/316 (27%), Positives = 136/316 (43%), Gaps = 62/316 (19%)

Query: 51  RSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRL--WDVARAKCLRVLKGHQRS- 107
           R  Q  W+    T  V F   SPDG  FA +   C V+L  W +      +  +   RS 
Sbjct: 17  RPHQFDWKSSCETWSVAF---SPDGSWFAWSQGHCIVKLIPWPLEEQFIPKGFEAKSRSS 73

Query: 108 --------------------VETVSF----SPDSRQ----------------LASGGWDK 127
                               V  ++F    SP SR+                LA+G  D 
Sbjct: 74  KNETKGRGSPKEKTLDCGQIVWGLAFSPWPSPPSRKLWARHHPQVPDVSCLVLATGLNDG 133

Query: 128 RVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVN-CLATGSWDSTVHIWDLRMVTPAVSHQ 186
           ++ +W+VQ+G +L  L GH+D ++   F+P+ +  L + S D T+ IWDL      +  Q
Sbjct: 134 QIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQI--Q 191

Query: 187 ALEGHSANISCLCYSAS-GLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDE 245
            L GH   + C   S    +L S + +K++ +W   + +L+ +L+GH + V S  FSPD 
Sbjct: 192 VLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDS 251

Query: 246 LWLASAGYSRMVKVWDCNTGKCLETLKGV------------LDVAHTCAFTPDGKILVSG 293
             L +A Y   V +WD  TG+ L +L               +    +  F+P+G  L + 
Sbjct: 252 ALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEGLYLATV 311

Query: 294 AADQTRRQISRTSKSP 309
           A D+  R  +   K+P
Sbjct: 312 ADDRLLRIWALELKTP 327



 Score = 70.5 bits (171), Expect = 2e-12
 Identities = 52/188 (27%), Positives = 81/188 (43%), Gaps = 18/188 (9%)

Query: 12  RRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRF 71
           ++++    H   V   + SPD  ML + + +  V+ W  RS  L+ +L GH   V  C F
Sbjct: 188 KQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDF 247

Query: 72  SPDGHLFASASCDCTVRLWDVARAKCLRVLKG------------HQRSVETVSFSPDSRQ 119
           SPD  L  +AS D  V +WD    + LR L              H  S+ +V FSP+   
Sbjct: 248 SPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEGLY 307

Query: 120 LASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQS--SDFSPTVNCLATGSWDSTVHIWDLR 177
           LA+   D+ + +W ++    L+  +            F P    +ATG+ D  V  W   
Sbjct: 308 LATVADDRLLRIWALE----LKTPIAFAPMTNGLCCTFFPHGGVIATGTRDGHVQFWTAP 363

Query: 178 MVTPAVSH 185
            V  ++ H
Sbjct: 364 RVLSSLKH 371


>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
           [Homo sapiens]
          Length = 340

 Score =  115 bits (288), Expect = 5e-26
 Identities = 72/243 (29%), Positives = 115/243 (47%), Gaps = 7/243 (2%)

Query: 24  VNSSAFSPDGQMLLTGSEDGC--VYGWETRSG--QLLWRLGGHTGPVKFCRFSPDGHLFA 79
           V + A++P G  +  G  D    +Y  +TR G  ++   L GHTG +  CRF  D  +  
Sbjct: 100 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVT 159

Query: 80  SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
           S+  D T  LWD+   +      GH   V ++S +PD+R   SG  D    LWDV+ G  
Sbjct: 160 SSG-DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMC 218

Query: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLC 199
            +   GH   I +  F P  N  ATGS D+T  ++DLR     +++   +     I+ + 
Sbjct: 219 RQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSH-DNIICGITSVS 277

Query: 200 YSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVK 258
           +S SG LL +G  D   ++W    +     L GH   V  +  + D + +A+  +   +K
Sbjct: 278 FSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLK 337

Query: 259 VWD 261
           +W+
Sbjct: 338 IWN 340



 Score =  107 bits (268), Expect = 1e-23
 Identities = 64/212 (30%), Positives = 98/212 (46%), Gaps = 9/212 (4%)

Query: 11  VRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCR 70
           VR  +    H G ++   F  D Q++ +  +  C   W+  +GQ      GHTG V    
Sbjct: 133 VRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCAL-WDIETGQQTTTFTGHTGDVMSLS 191

Query: 71  FSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVM 130
            +PD  LF S +CD + +LWDV    C +   GH+  +  + F P+    A+G  D    
Sbjct: 192 LAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCR 251

Query: 131 LWDVQSGQMLRLLVGHRD---SIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQA 187
           L+D+++ Q L +   H +    I S  FS +   L  G  D   ++WD      A     
Sbjct: 252 LFDLRADQEL-MTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRA---GV 307

Query: 188 LEGHSANISCLCYSASGL-LASGSWDKTIHIW 218
           L GH   +SCL  +  G+ +A+GSWD  + IW
Sbjct: 308 LAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339



 Score = 87.8 bits (216), Expect = 1e-17
 Identities = 51/203 (25%), Positives = 88/203 (43%), Gaps = 1/203 (0%)

Query: 99  RVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPT 158
           R L+GH   +  + +  DSR L S   D ++++WD  +   +  +      + +  ++P+
Sbjct: 49  RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108

Query: 159 VNCLATGSWDSTVHIWDLRMVTPAVS-HQALEGHSANISCLCYSASGLLASGSWDKTIHI 217
            N +A G  D+   I++L+     V   + L GH+  +SC  +     + + S D T  +
Sbjct: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCAL 168

Query: 218 WKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDV 277
           W   T        GH   V S++ +PD     S       K+WD   G C +T  G    
Sbjct: 169 WDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESD 228

Query: 278 AHTCAFTPDGKILVSGAADQTRR 300
            +   F P+G    +G+ D T R
Sbjct: 229 INAICFFPNGNAFATGSDDATCR 251



 Score = 83.2 bits (204), Expect = 3e-16
 Identities = 50/162 (30%), Positives = 77/162 (47%), Gaps = 4/162 (2%)

Query: 17  FGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGH 76
           F  H G+V S + +PD ++ ++G+ D     W+ R G       GH   +    F P+G+
Sbjct: 180 FTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGN 239

Query: 77  LFASASCDCTVRLWDVARAKCLRVLKGHQR---SVETVSFSPDSRQLASGGWDKRVMLWD 133
            FA+ S D T RL+D+ RA    +   H      + +VSFS   R L +G  D    +WD
Sbjct: 240 AFATGSDDATCRLFDL-RADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWD 298

Query: 134 VQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWD 175
                   +L GH + +     +     +ATGSWDS + IW+
Sbjct: 299 ALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340



 Score = 68.2 bits (165), Expect = 9e-12
 Identities = 61/287 (21%), Positives = 101/287 (35%), Gaps = 53/287 (18%)

Query: 59  LGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSR 118
           L GH   +    +  D  L  SAS D  + +WD      +  +      V T +++P   
Sbjct: 51  LRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGN 110

Query: 119 QLASGGWDK---------------------------------------------RVMLWD 133
            +A GG D                                                 LWD
Sbjct: 111 YVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWD 170

Query: 134 VQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSA 193
           +++GQ      GH   + S   +P      +G+ D++  +WD+R     +  Q   GH +
Sbjct: 171 IETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVR---EGMCRQTFTGHES 227

Query: 194 NISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLK--GHVTWVKSIAFSPDELWLAS 250
           +I+ +C+  +G   A+GS D T  ++       L+       +  + S++FS     L  
Sbjct: 228 DINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGR-LLL 286

Query: 251 AGYSRM-VKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAAD 296
           AGY      VWD         L G  +       T DG  + +G+ D
Sbjct: 287 AGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWD 333


>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
           sapiens]
          Length = 589

 Score =  113 bits (282), Expect = 2e-25
 Identities = 67/241 (27%), Positives = 121/241 (50%), Gaps = 12/241 (4%)

Query: 33  GQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDV 92
           G  +++GS+D  +  W   +G+ L  L GHTG V   +   +  +  S S D T+++W+ 
Sbjct: 273 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNA 330

Query: 93  ARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQS 152
              +C+  L GH  +V  +      +++ SG  D  + +WD+++GQ L +L+GH  +++ 
Sbjct: 331 ETGECIHTLYGHTSTVRCMHLH--EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRC 388

Query: 153 SDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWD 212
             +      + +G++D  V +WD    T       L+GH+  +  L +    ++ SGS D
Sbjct: 389 VQYDG--RRVVSGAYDFMVKVWDPETETCL---HTLQGHTNRVYSLQFDGIHVV-SGSLD 442

Query: 213 KTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLK 272
            +I +W   T + +  L GH +    +    + L   S      VK+WD  TG+CL+TL+
Sbjct: 443 TSIRVWDVETGNCIHTLTGHQSLTSGMELKDNIL--VSGNADSTVKIWDIKTGQCLQTLQ 500

Query: 273 G 273
           G
Sbjct: 501 G 501



 Score =  107 bits (266), Expect = 2e-23
 Identities = 77/255 (30%), Positives = 127/255 (49%), Gaps = 17/255 (6%)

Query: 20  HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
           H G V SS    +  ++++GS D  +  W   +G+ +  L GHT  V+ C    +  +  
Sbjct: 302 HTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVR-CMHLHEKRV-V 357

Query: 80  SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
           S S D T+R+WD+   +CL VL GH  +V  V +  D R++ SG +D  V +WD ++   
Sbjct: 358 SGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETC 415

Query: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLC 199
           L  L GH + + S  F      + +GS D+++ +WD+   T    H  L GH +  S + 
Sbjct: 416 LHTLQGHTNRVYSLQFDGI--HVVSGSLDTSIRVWDVE--TGNCIH-TLTGHQSLTSGM- 469

Query: 200 YSASGLLASGSWDKTIHIWKPTTSSLLIQLKG---HVTWVKSIAFSPDELWLASAGYSRM 256
                +L SG+ D T+ IW   T   L  L+G   H + V  + F+ +  ++ ++     
Sbjct: 470 ELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGT 527

Query: 257 VKVWDCNTGKCLETL 271
           VK+WD  TG+ +  L
Sbjct: 528 VKLWDLKTGEFIRNL 542



 Score = 99.0 bits (245), Expect = 5e-21
 Identities = 71/211 (33%), Positives = 103/211 (48%), Gaps = 11/211 (5%)

Query: 90  WDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDS 149
           W     K  +VLKGH   V T      +R + SG  D  + +W   +G+ LR LVGH   
Sbjct: 247 WRRGELKSPKVLKGHDDHVITCLQFCGNR-IVSGSDDNTLKVWSAVTGKCLRTLVGHTGG 305

Query: 150 IQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASG 209
           + SS      N + +GS D T+ +W+    T    H  L GH++ + C+ +     + SG
Sbjct: 306 VWSSQMRD--NIIISGSTDRTLKVWNAE--TGECIH-TLYGHTSTVRCM-HLHEKRVVSG 359

Query: 210 SWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLE 269
           S D T+ +W   T   L  L GHV  V+ + +  D   + S  Y  MVKVWD  T  CL 
Sbjct: 360 SRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLH 417

Query: 270 TLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
           TL+G  +  ++  F  DG  +VSG+ D + R
Sbjct: 418 TLQGHTNRVYSLQF--DGIHVVSGSLDTSIR 446


>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
           sapiens]
          Length = 707

 Score =  113 bits (282), Expect = 2e-25
 Identities = 67/241 (27%), Positives = 121/241 (50%), Gaps = 12/241 (4%)

Query: 33  GQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDV 92
           G  +++GS+D  +  W   +G+ L  L GHTG V   +   +  +  S S D T+++W+ 
Sbjct: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNA 448

Query: 93  ARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQS 152
              +C+  L GH  +V  +      +++ SG  D  + +WD+++GQ L +L+GH  +++ 
Sbjct: 449 ETGECIHTLYGHTSTVRCMHLH--EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRC 506

Query: 153 SDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWD 212
             +      + +G++D  V +WD    T       L+GH+  +  L +    ++ SGS D
Sbjct: 507 VQYDG--RRVVSGAYDFMVKVWDPETETCL---HTLQGHTNRVYSLQFDGIHVV-SGSLD 560

Query: 213 KTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLK 272
            +I +W   T + +  L GH +    +    + L   S      VK+WD  TG+CL+TL+
Sbjct: 561 TSIRVWDVETGNCIHTLTGHQSLTSGMELKDNIL--VSGNADSTVKIWDIKTGQCLQTLQ 618

Query: 273 G 273
           G
Sbjct: 619 G 619



 Score =  107 bits (266), Expect = 2e-23
 Identities = 77/255 (30%), Positives = 127/255 (49%), Gaps = 17/255 (6%)

Query: 20  HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
           H G V SS    +  ++++GS D  +  W   +G+ +  L GHT  V+ C    +  +  
Sbjct: 420 HTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVR-CMHLHEKRV-V 475

Query: 80  SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
           S S D T+R+WD+   +CL VL GH  +V  V +  D R++ SG +D  V +WD ++   
Sbjct: 476 SGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETC 533

Query: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLC 199
           L  L GH + + S  F      + +GS D+++ +WD+   T    H  L GH +  S + 
Sbjct: 534 LHTLQGHTNRVYSLQFDGI--HVVSGSLDTSIRVWDVE--TGNCIH-TLTGHQSLTSGM- 587

Query: 200 YSASGLLASGSWDKTIHIWKPTTSSLLIQLKG---HVTWVKSIAFSPDELWLASAGYSRM 256
                +L SG+ D T+ IW   T   L  L+G   H + V  + F+ +  ++ ++     
Sbjct: 588 ELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGT 645

Query: 257 VKVWDCNTGKCLETL 271
           VK+WD  TG+ +  L
Sbjct: 646 VKLWDLKTGEFIRNL 660



 Score = 99.0 bits (245), Expect = 5e-21
 Identities = 71/211 (33%), Positives = 103/211 (48%), Gaps = 11/211 (5%)

Query: 90  WDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDS 149
           W     K  +VLKGH   V T      +R + SG  D  + +W   +G+ LR LVGH   
Sbjct: 365 WRRGELKSPKVLKGHDDHVITCLQFCGNR-IVSGSDDNTLKVWSAVTGKCLRTLVGHTGG 423

Query: 150 IQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASG 209
           + SS      N + +GS D T+ +W+    T    H  L GH++ + C+ +     + SG
Sbjct: 424 VWSSQMRD--NIIISGSTDRTLKVWNAE--TGECIH-TLYGHTSTVRCM-HLHEKRVVSG 477

Query: 210 SWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLE 269
           S D T+ +W   T   L  L GHV  V+ + +  D   + S  Y  MVKVWD  T  CL 
Sbjct: 478 SRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLH 535

Query: 270 TLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
           TL+G  +  ++  F  DG  +VSG+ D + R
Sbjct: 536 TLQGHTNRVYSLQF--DGIHVVSGSLDTSIR 564


>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
           sapiens]
          Length = 627

 Score =  113 bits (282), Expect = 2e-25
 Identities = 67/241 (27%), Positives = 121/241 (50%), Gaps = 12/241 (4%)

Query: 33  GQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDV 92
           G  +++GS+D  +  W   +G+ L  L GHTG V   +   +  +  S S D T+++W+ 
Sbjct: 311 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNA 368

Query: 93  ARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQS 152
              +C+  L GH  +V  +      +++ SG  D  + +WD+++GQ L +L+GH  +++ 
Sbjct: 369 ETGECIHTLYGHTSTVRCMHLH--EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRC 426

Query: 153 SDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWD 212
             +      + +G++D  V +WD    T       L+GH+  +  L +    ++ SGS D
Sbjct: 427 VQYDG--RRVVSGAYDFMVKVWDPETETCL---HTLQGHTNRVYSLQFDGIHVV-SGSLD 480

Query: 213 KTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLK 272
            +I +W   T + +  L GH +    +    + L   S      VK+WD  TG+CL+TL+
Sbjct: 481 TSIRVWDVETGNCIHTLTGHQSLTSGMELKDNIL--VSGNADSTVKIWDIKTGQCLQTLQ 538

Query: 273 G 273
           G
Sbjct: 539 G 539



 Score =  107 bits (266), Expect = 2e-23
 Identities = 77/255 (30%), Positives = 127/255 (49%), Gaps = 17/255 (6%)

Query: 20  HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
           H G V SS    +  ++++GS D  +  W   +G+ +  L GHT  V+ C    +  +  
Sbjct: 340 HTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVR-CMHLHEKRV-V 395

Query: 80  SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
           S S D T+R+WD+   +CL VL GH  +V  V +  D R++ SG +D  V +WD ++   
Sbjct: 396 SGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETC 453

Query: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLC 199
           L  L GH + + S  F      + +GS D+++ +WD+   T    H  L GH +  S + 
Sbjct: 454 LHTLQGHTNRVYSLQFDGI--HVVSGSLDTSIRVWDVE--TGNCIH-TLTGHQSLTSGM- 507

Query: 200 YSASGLLASGSWDKTIHIWKPTTSSLLIQLKG---HVTWVKSIAFSPDELWLASAGYSRM 256
                +L SG+ D T+ IW   T   L  L+G   H + V  + F+ +  ++ ++     
Sbjct: 508 ELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGT 565

Query: 257 VKVWDCNTGKCLETL 271
           VK+WD  TG+ +  L
Sbjct: 566 VKLWDLKTGEFIRNL 580



 Score = 99.0 bits (245), Expect = 5e-21
 Identities = 71/211 (33%), Positives = 103/211 (48%), Gaps = 11/211 (5%)

Query: 90  WDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDS 149
           W     K  +VLKGH   V T      +R + SG  D  + +W   +G+ LR LVGH   
Sbjct: 285 WRRGELKSPKVLKGHDDHVITCLQFCGNR-IVSGSDDNTLKVWSAVTGKCLRTLVGHTGG 343

Query: 150 IQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASG 209
           + SS      N + +GS D T+ +W+    T    H  L GH++ + C+ +     + SG
Sbjct: 344 VWSSQMRD--NIIISGSTDRTLKVWNAE--TGECIH-TLYGHTSTVRCM-HLHEKRVVSG 397

Query: 210 SWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLE 269
           S D T+ +W   T   L  L GHV  V+ + +  D   + S  Y  MVKVWD  T  CL 
Sbjct: 398 SRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLH 455

Query: 270 TLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
           TL+G  +  ++  F  DG  +VSG+ D + R
Sbjct: 456 TLQGHTNRVYSLQF--DGIHVVSGSLDTSIR 484


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.132    0.430 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,859,434
Number of Sequences: 37866
Number of extensions: 551529
Number of successful extensions: 5437
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 279
Number of HSP's successfully gapped in prelim test: 74
Number of HSP's that attempted gapping in prelim test: 1171
Number of HSP's gapped (non-prelim): 1838
length of query: 314
length of database: 18,247,518
effective HSP length: 102
effective length of query: 212
effective length of database: 14,385,186
effective search space: 3049659432
effective search space used: 3049659432
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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