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Search of human proteins with 113865883
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|113865883 WD repeat domain 38 [Homo sapiens]
(314 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|113865883 WD repeat domain 38 [Homo sapiens] 654 0.0
gi|32189425 WD repeat domain 69 [Homo sapiens] 164 1e-40
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 145 6e-35
gi|157266266 WD repeat domain 86 [Homo sapiens] 142 3e-34
gi|21071067 TBP-associated factor 5 [Homo sapiens] 137 9e-33
gi|16554629 WD repeat domain 5 [Homo sapiens] 134 1e-31
gi|16554627 WD repeat domain 5 [Homo sapiens] 134 1e-31
gi|23199987 WD repeat domain 5B [Homo sapiens] 134 1e-31
gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo ... 132 4e-31
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 130 2e-30
gi|26665869 WD repeat domain 51B [Homo sapiens] 130 2e-30
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 125 4e-29
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 125 4e-29
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 125 4e-29
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 125 6e-29
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 123 2e-28
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 122 3e-28
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa... 122 4e-28
gi|13376840 WD repeat domain 61 [Homo sapiens] 122 5e-28
gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo ... 120 2e-27
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 119 3e-27
gi|189571685 WD repeat, sterile alpha motif and U-box domain con... 119 3e-27
gi|189571683 WD repeat, sterile alpha motif and U-box domain con... 119 3e-27
gi|189571681 WD repeat, sterile alpha motif and U-box domain con... 119 3e-27
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 119 5e-27
gi|8923881 WD SOCS-box protein 2 [Homo sapiens] 118 8e-27
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 115 5e-26
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 113 2e-25
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 113 2e-25
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 113 2e-25
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 654 bits (1688), Expect = 0.0
Identities = 314/314 (100%), Positives = 314/314 (100%)
Query: 1 MNSGVPATLAVRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLG 60
MNSGVPATLAVRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLG
Sbjct: 1 MNSGVPATLAVRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLG 60
Query: 61 GHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQL 120
GHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQL
Sbjct: 61 GHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQL 120
Query: 121 ASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVT 180
ASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVT
Sbjct: 121 ASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVT 180
Query: 181 PAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIA 240
PAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIA
Sbjct: 181 PAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIA 240
Query: 241 FSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
FSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR
Sbjct: 241 FSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
Query: 301 QISRTSKSPRDPQT 314
QISRTSKSPRDPQT
Sbjct: 301 QISRTSKSPRDPQT 314
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 164 bits (414), Expect = 1e-40
Identities = 88/283 (31%), Positives = 144/283 (50%), Gaps = 5/283 (1%)
Query: 20 HGGEVNSSAFS-PDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLF 78
H V + AF+ P G + TGS D W +G+ GHT + F+P L
Sbjct: 133 HRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLV 192
Query: 79 ASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQ 138
A+ S D T +LWD+ + + L+GH + ++SF+ ++ +G +D V++WD +G+
Sbjct: 193 ATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGR 252
Query: 139 MLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCL 198
+ +L+GH I S+ F+ + + TGS D T +WD T L GH I
Sbjct: 253 KVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWD---ATNGKCVATLTGHDDEILDS 309
Query: 199 CYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMV 257
C+ +G L+A+ S D T I+ T + +L+GH + I+F+P L + +
Sbjct: 310 CFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTA 369
Query: 258 KVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
++WD TG+CL+ L+G D +CAF G I+++G+ D T R
Sbjct: 370 RIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCR 412
Score = 134 bits (338), Expect = 8e-32
Identities = 79/251 (31%), Positives = 125/251 (49%), Gaps = 5/251 (1%)
Query: 59 LGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFS-PDS 117
L H P+ + G F + S D T +LWD A + L L+GH+ V ++F+ P
Sbjct: 88 LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYG 147
Query: 118 RQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLR 177
++A+G +DK LW V++G+ GH I F+P +ATGS D+T +WD++
Sbjct: 148 DKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQ 207
Query: 178 MVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWV 236
+ L GHSA I L ++ SG + +GS+D T+ +W T + L GH +
Sbjct: 208 NGEEVYT---LRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEI 264
Query: 237 KSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAAD 296
S +F+ D + + + K+WD GKC+ TL G D F GK++ + +AD
Sbjct: 265 SSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASAD 324
Query: 297 QTRRQISRTSK 307
T R S ++
Sbjct: 325 GTARIFSAATR 335
Score = 119 bits (299), Expect = 3e-27
Identities = 73/245 (29%), Positives = 113/245 (46%), Gaps = 4/245 (1%)
Query: 17 FGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGH 76
F H E+ +F+P ++ TGS D W+ ++G+ ++ L GH+ + F+ G
Sbjct: 173 FRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGD 232
Query: 77 LFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQS 136
+ S D TV +WD + + +L GH + + SF+ D + +G DK LWD +
Sbjct: 233 RIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATN 292
Query: 137 GQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANIS 196
G+ + L GH D I S F T +AT S D T I+ LEGH IS
Sbjct: 293 GKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFS---AATRKCIAKLEGHEGEIS 349
Query: 197 CLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSR 255
+ ++ G L +GS DKT IW T L L+GH + S AF+ + +
Sbjct: 350 KISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDN 409
Query: 256 MVKVW 260
++W
Sbjct: 410 TCRIW 414
Score = 116 bits (291), Expect = 2e-26
Identities = 60/163 (36%), Positives = 90/163 (55%)
Query: 12 RRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRF 71
R+V H E++S++F+ D ++LTGS D W+ +G+ + L GH + F
Sbjct: 252 RKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCF 311
Query: 72 SPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVML 131
G L A+AS D T R++ A KC+ L+GH+ + +SF+P L +G DK +
Sbjct: 312 DYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARI 371
Query: 132 WDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIW 174
WD Q+GQ L++L GH D I S F+ N + TGS D+T IW
Sbjct: 372 WDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 105 bits (261), Expect = 7e-23
Identities = 62/201 (30%), Positives = 92/201 (45%), Gaps = 4/201 (1%)
Query: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
H E+ S +F+ G ++TGS D V W+ +G+ + L GH + F+ D L
Sbjct: 218 HSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLIL 277
Query: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
+ S D T +LWD KC+ L GH + F + +A+ D ++ + +
Sbjct: 278 TGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKC 337
Query: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANI-SCL 198
+ L GH I F+P N L TGS D T IWD + Q LEGH+ I SC
Sbjct: 338 IAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQT---GQCLQVLEGHTDEIFSCA 394
Query: 199 CYSASGLLASGSWDKTIHIWK 219
++ +GS D T IW+
Sbjct: 395 FNYKGNIVITGSKDNTCRIWR 415
Score = 101 bits (251), Expect = 1e-21
Identities = 59/202 (29%), Positives = 102/202 (50%), Gaps = 5/202 (2%)
Query: 99 RVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDF-SP 157
+VLK H + V+ + +G +D+ LWD SG+ L L GHR+ + + F +P
Sbjct: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNP 145
Query: 158 TVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYS-ASGLLASGSWDKTIH 216
+ +ATGS+D T +W V + GH+A I CL ++ S L+A+GS D T
Sbjct: 146 YGDKIATGSFDKTCKLWS---VETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAK 202
Query: 217 IWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLD 276
+W + L+GH + S++F+ + + + V VWD +TG+ + L G
Sbjct: 203 LWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCA 262
Query: 277 VAHTCAFTPDGKILVSGAADQT 298
+ +F D ++++G+ D+T
Sbjct: 263 EISSASFNWDCSLILTGSMDKT 284
Score = 70.5 bits (171), Expect = 2e-12
Identities = 39/162 (24%), Positives = 74/162 (45%), Gaps = 5/162 (3%)
Query: 139 MLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCL 198
+ ++L H + + + + +C TGS+D T +WD LEGH + +
Sbjct: 84 LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWD---TASGEELNTLEGHRNVVYAI 140
Query: 199 CYS--ASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRM 256
++ +A+GS+DKT +W T +GH + ++F+P +A+
Sbjct: 141 AFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTT 200
Query: 257 VKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQT 298
K+WD G+ + TL+G + +F G +++G+ D T
Sbjct: 201 AKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHT 242
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 145 bits (365), Expect = 6e-35
Identities = 84/300 (28%), Positives = 138/300 (46%), Gaps = 24/300 (8%)
Query: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
H V F P ++++ SED + W+ +G L GHT V+ F G L A
Sbjct: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLA 166
Query: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
S S D T++LWD +C+R + GH +V +V+ P+ + S DK + +W+VQ+G
Sbjct: 167 SCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYC 226
Query: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLC 199
++ GHR+ ++ + +A+ S D TV +W +V L H + C+
Sbjct: 227 VKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW---VVATKECKAELREHEHVVECIS 283
Query: 200 YS----------ASG-----------LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKS 238
++ A+G L SGS DKTI +W +T L+ L GH WV+
Sbjct: 284 WAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRG 343
Query: 239 IAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQT 298
+ F ++ S + ++VWD +C++TL + F +V+G+ DQT
Sbjct: 344 VLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQT 403
Score = 117 bits (293), Expect = 1e-26
Identities = 77/265 (29%), Positives = 121/265 (45%), Gaps = 24/265 (9%)
Query: 57 WRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPD 116
+ L GH PV F P + SAS D T+++WD R LKGH SV+ +SF
Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHS 161
Query: 117 SRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDL 176
+ LAS D + LWD Q + +R + GH ++ S P + + + S D T+ +W+
Sbjct: 162 GKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWE- 220
Query: 177 RMVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTW 235
V + GH + + + G L+AS S D+T+ +W T +L+ H
Sbjct: 221 --VQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHV 278
Query: 236 VKSIAFSPDELW--------------------LASAGYSRMVKVWDCNTGKCLETLKGVL 275
V+ I+++P+ + L S + +K+WD +TG CL TL G
Sbjct: 279 VECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHD 338
Query: 276 DVAHTCAFTPDGKILVSGAADQTRR 300
+ F GK ++S A D+T R
Sbjct: 339 NWVRGVLFHSGGKFILSCADDKTLR 363
Score = 88.2 bits (217), Expect = 9e-18
Identities = 62/220 (28%), Positives = 90/220 (40%), Gaps = 62/220 (28%)
Query: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
H V+S A P+G +++ S D + WE ++G + GH V+ R + DG L A
Sbjct: 191 HDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIA 250
Query: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQ-------------------- 119
S S D TVR+W VA +C L+ H+ VE +S++P+S
Sbjct: 251 SCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPF 310
Query: 120 LASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQ---------------------------- 151
L SG DK + +WDV +G L LVGH + ++
Sbjct: 311 LLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNK 370
Query: 152 --------------SSDFSPTVNCLATGSWDSTVHIWDLR 177
S DF T + TGS D TV +W+ R
Sbjct: 371 RCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410
>gi|157266266 WD repeat domain 86 [Homo sapiens]
Length = 376
Score = 142 bits (359), Expect = 3e-34
Identities = 93/266 (34%), Positives = 124/266 (46%), Gaps = 24/266 (9%)
Query: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
H G +N + SPDGQ LLTGSEDG W T GQ L GH V FC+ +
Sbjct: 14 HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTC 73
Query: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
SA DCT+R WDV +CL+V +GH V + + + QL S +D+ +W V GQM
Sbjct: 74 SA--DCTIRRWDVLTGQCLQVYRGHTSIVNRILVA--NNQLFSSSYDRTARVWSVDKGQM 129
Query: 140 LRLLVGHRDSIQSSDFS-----PTVNC---------LATGSWDSTVHIWDLRMVTPAVSH 185
R GHR+ + + +S P+ C L TGS D T +W V H
Sbjct: 130 SREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVW---QVASGCCH 186
Query: 186 QALEGHSANISCLCYSASGLLA-SGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPD 244
Q L GH+ + CL G A +GS D TI W + L + H V +
Sbjct: 187 QTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNR 246
Query: 245 ELWLASAGYSRMVKVWDCNTGKCLET 270
++ SA R VK W +TG+C+ T
Sbjct: 247 LVYSGSA--DRTVKCWLADTGECVRT 270
Score = 73.9 bits (180), Expect = 2e-13
Identities = 57/217 (26%), Positives = 87/217 (40%), Gaps = 20/217 (9%)
Query: 98 LRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSP 157
LRV H+ + +S SPD ++L +G D LW GQ LL GH +
Sbjct: 8 LRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLED 67
Query: 158 TVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHI 217
T S D T+ WD V Q GH++ ++ + A+ L S S+D+T +
Sbjct: 68 --EAAFTCSADCTIRRWD---VLTGQCLQVYRGHTSIVNRILV-ANNQLFSSSYDRTARV 121
Query: 218 WKPTTSSLLIQLKGHVTWVKSIAFS-PDEL-------------WLASAGYSRMVKVWDCN 263
W + + +GH V ++A+S P +L L + KVW
Sbjct: 122 WSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVA 181
Query: 264 TGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
+G C +TL+G G +G+ D T R
Sbjct: 182 SGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIR 218
Score = 65.9 bits (159), Expect = 5e-11
Identities = 46/158 (29%), Positives = 65/158 (41%), Gaps = 6/158 (3%)
Query: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
H G V G TGS D + W+ SG+ L H G V L
Sbjct: 192 HTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELV--NRLVY 249
Query: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
S S D TV+ W +C+R H+R+V + + + L +G D +D QSG++
Sbjct: 250 SGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGT--LFTGSGDACARAFDAQSGEL 307
Query: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLR 177
R+ GH I V L T S D + +WD+R
Sbjct: 308 RRVFRGHTFIINCIQVHGQV--LYTASHDGALRLWDVR 343
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 137 bits (346), Expect = 9e-33
Identities = 78/206 (37%), Positives = 107/206 (51%), Gaps = 4/206 (1%)
Query: 14 VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSP 73
+K H G V ++FSPD LL+ SEDG V W ++ L GH PV +FSP
Sbjct: 536 LKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSP 595
Query: 74 DGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 133
G+ F S D RLW + LR+ GH V F P+S +A+G D+ V LWD
Sbjct: 596 YGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWD 655
Query: 134 VQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSA 193
V +G +R+ GH+ I S FSP LATG+ D V +WD + + L+GH+
Sbjct: 656 VLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWD---IGHGLMVGELKGHTD 712
Query: 194 NISCLCYSASG-LLASGSWDKTIHIW 218
+ L +S G +LASGS D T+ +W
Sbjct: 713 TVCSLRFSRDGEILASGSMDNTVRLW 738
Score = 125 bits (313), Expect = 6e-29
Identities = 77/204 (37%), Positives = 100/204 (49%), Gaps = 4/204 (1%)
Query: 59 LGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSR 118
L GH+GPV FSPD + S+S D TVRLW + CL KGH V FSP
Sbjct: 539 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGY 598
Query: 119 QLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRM 178
SGG D+ LW Q LR+ GH + + F P N +ATGS D TV +WD
Sbjct: 599 YFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWD--- 655
Query: 179 VTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVK 237
V + GH I L +S +G LA+G+ D + +W ++ +LKGH V
Sbjct: 656 VLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVC 715
Query: 238 SIAFSPDELWLASAGYSRMVKVWD 261
S+ FS D LAS V++WD
Sbjct: 716 SLRFSRDGEILASGSMDNTVRLWD 739
Score = 121 bits (303), Expect = 9e-28
Identities = 63/156 (40%), Positives = 86/156 (55%)
Query: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
H V + FSP G ++G D W T Q L GH V RF P+ + A
Sbjct: 584 HNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVA 643
Query: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
+ S D TVRLWDV C+R+ GH+ + +++FSP+ R LA+G D RV+LWD+ G M
Sbjct: 644 TGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLM 703
Query: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWD 175
+ L GH D++ S FS LA+GS D+TV +WD
Sbjct: 704 VGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
Score = 108 bits (271), Expect = 5e-24
Identities = 77/270 (28%), Positives = 115/270 (42%), Gaps = 15/270 (5%)
Query: 32 DGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWD 91
D ++ G D V W +L + + + D L S D R+ D
Sbjct: 481 DSSLIAGGFADSTVRVWSVTPKKL-----------RSVKQASDLSLIDKESDDVLERIMD 529
Query: 92 VARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQ 151
A L++L GH V SFSPD L S D V LW +Q+ L GH +
Sbjct: 530 EKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVW 589
Query: 152 SSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSA-SGLLASGS 210
+ FSP +G D +W P + GH A+++C + S +A+GS
Sbjct: 590 DTQFSPYGYYFVSGGHDRVARLWATDHYQPL---RIFAGHLADVNCTRFHPNSNYVATGS 646
Query: 211 WDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLET 270
D+T+ +W + + GH + S+ FSP+ +LA+ V +WD G +
Sbjct: 647 ADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGE 706
Query: 271 LKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
LKG D + F+ DG+IL SG+ D T R
Sbjct: 707 LKGHTDTVCSLRFSRDGEILASGSMDNTVR 736
Score = 87.0 bits (214), Expect = 2e-17
Identities = 46/127 (36%), Positives = 65/127 (51%)
Query: 7 ATLAVRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPV 66
AT + ++ F H +VN + F P+ + TGS D V W+ +G + GH GP+
Sbjct: 613 ATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPI 672
Query: 67 KFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWD 126
FSP+G A+ + D V LWD+ + LKGH +V ++ FS D LASG D
Sbjct: 673 HSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMD 732
Query: 127 KRVMLWD 133
V LWD
Sbjct: 733 NTVRLWD 739
Score = 75.5 bits (184), Expect = 6e-14
Identities = 38/82 (46%), Positives = 49/82 (59%)
Query: 14 VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSP 73
V+ F H G ++S FSP+G+ L TG+ DG V W+ G ++ L GHT V RFS
Sbjct: 662 VRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSR 721
Query: 74 DGHLFASASCDCTVRLWDVARA 95
DG + AS S D TVRLWD +A
Sbjct: 722 DGEILASGSMDNTVRLWDAIKA 743
Score = 54.3 bits (129), Expect = 1e-07
Identities = 45/176 (25%), Positives = 71/176 (40%), Gaps = 29/176 (16%)
Query: 154 DFSPTVNCLATGSWDSTVHIW--------------DLRMV--------------TPAVSH 185
D + + +A G DSTV +W DL ++ A
Sbjct: 477 DVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASEL 536
Query: 186 QALEGHSANISCLCYSAS-GLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPD 244
+ L GHS + +S L S S D T+ +W T + L+ KGH V FSP
Sbjct: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPY 596
Query: 245 ELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
+ S G+ R+ ++W + + L G L + F P+ + +G+AD+T R
Sbjct: 597 GYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVR 652
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 134 bits (337), Expect = 1e-31
Identities = 79/285 (27%), Positives = 139/285 (48%), Gaps = 8/285 (2%)
Query: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
H V+S FSP+G+ L + S D + W G+ + GH + +S D +L
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV 103
Query: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
SAS D T+++WDV+ KCL+ LKGH V +F+P S + SG +D+ V +WDV++G+
Sbjct: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC 163
Query: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLC 199
L+ L H D + + F+ + + + S+D IWD + ++ + +S +
Sbjct: 164 LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD--TASGQCLKTLIDDDNPPVSFVK 221
Query: 200 YSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDEL----WLASAGYS 254
+S +G + + + D T+ +W + L GH K F+ + W+ S
Sbjct: 222 FSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKN-EKYCIFANFSVTGGKWIVSGSED 280
Query: 255 RMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTR 299
+V +W+ T + ++ L+G DV + A P I+ S A + +
Sbjct: 281 NLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDK 325
Score = 133 bits (335), Expect = 2e-31
Identities = 83/251 (33%), Positives = 130/251 (51%), Gaps = 16/251 (6%)
Query: 55 LLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFS 114
L + L GHT V +FSP+G AS+S D +++W K + + GH+ + V++S
Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96
Query: 115 PDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIW 174
DS L S DK + +WDV SG+ L+ L GH + + +F+P N + +GS+D +V IW
Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
Query: 175 DLRMVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQL---- 229
D V + L HS +S + ++ G L+ S S+D IW + L L
Sbjct: 157 D---VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 213
Query: 230 KGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAF----TP 285
V++VK FSP+ ++ +A +K+WD + GKCL+T G + + C F
Sbjct: 214 NPPVSFVK---FSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKY-CIFANFSVT 269
Query: 286 DGKILVSGAAD 296
GK +VSG+ D
Sbjct: 270 GGKWIVSGSED 280
Score = 127 bits (319), Expect = 1e-29
Identities = 80/257 (31%), Positives = 124/257 (48%), Gaps = 12/257 (4%)
Query: 15 KFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPD 74
K H ++ A+S D +L++ S+D + W+ SG+ L L GH+ V C F+P
Sbjct: 81 KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ 140
Query: 75 GHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDV 134
+L S S D +VR+WDV KCL+ L H V V F+ D + S +D +WD
Sbjct: 141 SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200
Query: 135 QSGQMLRLLV-GHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSA 193
SGQ L+ L+ + FSP + + D+T+ +WD + + GH
Sbjct: 201 ASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD---YSKGKCLKTYTGHKN 257
Query: 194 NISCLC--YSASG--LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLA 249
C+ +S +G + SGS D ++IW T ++ +L+GH V S A P E +A
Sbjct: 258 EKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIA 317
Query: 250 SAGY--SRMVKVW--DC 262
SA + +K+W DC
Sbjct: 318 SAALENDKTIKLWKSDC 334
Score = 97.1 bits (240), Expect = 2e-20
Identities = 54/167 (32%), Positives = 92/167 (55%), Gaps = 6/167 (3%)
Query: 14 VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRL-GGHTGPVKFCRFS 72
+K H V++ F+ DG ++++ S DG W+T SGQ L L PV F +FS
Sbjct: 164 LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFS 223
Query: 73 PDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETV--SFS-PDSRQLASGGWDKRV 129
P+G +A+ D T++LWD ++ KCL+ GH+ + +FS + + SG D V
Sbjct: 224 PNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLV 283
Query: 130 MLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSW--DSTVHIW 174
+W++Q+ ++++ L GH D + S+ PT N +A+ + D T+ +W
Sbjct: 284 YIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 79.7 bits (195), Expect = 3e-15
Identities = 42/114 (36%), Positives = 63/114 (55%), Gaps = 1/114 (0%)
Query: 188 LEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDEL 246
L GH+ +S + +S +G LAS S DK I IW + GH + +A+S D
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
Query: 247 WLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
L SA + +K+WD ++GKCL+TLKG + C F P ++VSG+ D++ R
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 134 bits (337), Expect = 1e-31
Identities = 79/285 (27%), Positives = 139/285 (48%), Gaps = 8/285 (2%)
Query: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
H V+S FSP+G+ L + S D + W G+ + GH + +S D +L
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV 103
Query: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
SAS D T+++WDV+ KCL+ LKGH V +F+P S + SG +D+ V +WDV++G+
Sbjct: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC 163
Query: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLC 199
L+ L H D + + F+ + + + S+D IWD + ++ + +S +
Sbjct: 164 LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD--TASGQCLKTLIDDDNPPVSFVK 221
Query: 200 YSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDEL----WLASAGYS 254
+S +G + + + D T+ +W + L GH K F+ + W+ S
Sbjct: 222 FSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKN-EKYCIFANFSVTGGKWIVSGSED 280
Query: 255 RMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTR 299
+V +W+ T + ++ L+G DV + A P I+ S A + +
Sbjct: 281 NLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDK 325
Score = 133 bits (335), Expect = 2e-31
Identities = 83/251 (33%), Positives = 130/251 (51%), Gaps = 16/251 (6%)
Query: 55 LLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFS 114
L + L GHT V +FSP+G AS+S D +++W K + + GH+ + V++S
Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96
Query: 115 PDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIW 174
DS L S DK + +WDV SG+ L+ L GH + + +F+P N + +GS+D +V IW
Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
Query: 175 DLRMVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQL---- 229
D V + L HS +S + ++ G L+ S S+D IW + L L
Sbjct: 157 D---VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 213
Query: 230 KGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAF----TP 285
V++VK FSP+ ++ +A +K+WD + GKCL+T G + + C F
Sbjct: 214 NPPVSFVK---FSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKY-CIFANFSVT 269
Query: 286 DGKILVSGAAD 296
GK +VSG+ D
Sbjct: 270 GGKWIVSGSED 280
Score = 127 bits (319), Expect = 1e-29
Identities = 80/257 (31%), Positives = 124/257 (48%), Gaps = 12/257 (4%)
Query: 15 KFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPD 74
K H ++ A+S D +L++ S+D + W+ SG+ L L GH+ V C F+P
Sbjct: 81 KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ 140
Query: 75 GHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDV 134
+L S S D +VR+WDV KCL+ L H V V F+ D + S +D +WD
Sbjct: 141 SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200
Query: 135 QSGQMLRLLV-GHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSA 193
SGQ L+ L+ + FSP + + D+T+ +WD + + GH
Sbjct: 201 ASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD---YSKGKCLKTYTGHKN 257
Query: 194 NISCLC--YSASG--LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLA 249
C+ +S +G + SGS D ++IW T ++ +L+GH V S A P E +A
Sbjct: 258 EKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIA 317
Query: 250 SAGY--SRMVKVW--DC 262
SA + +K+W DC
Sbjct: 318 SAALENDKTIKLWKSDC 334
Score = 97.1 bits (240), Expect = 2e-20
Identities = 54/167 (32%), Positives = 92/167 (55%), Gaps = 6/167 (3%)
Query: 14 VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRL-GGHTGPVKFCRFS 72
+K H V++ F+ DG ++++ S DG W+T SGQ L L PV F +FS
Sbjct: 164 LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFS 223
Query: 73 PDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETV--SFS-PDSRQLASGGWDKRV 129
P+G +A+ D T++LWD ++ KCL+ GH+ + +FS + + SG D V
Sbjct: 224 PNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLV 283
Query: 130 MLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSW--DSTVHIW 174
+W++Q+ ++++ L GH D + S+ PT N +A+ + D T+ +W
Sbjct: 284 YIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 79.7 bits (195), Expect = 3e-15
Identities = 42/114 (36%), Positives = 63/114 (55%), Gaps = 1/114 (0%)
Query: 188 LEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDEL 246
L GH+ +S + +S +G LAS S DK I IW + GH + +A+S D
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
Query: 247 WLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
L SA + +K+WD ++GKCL+TLKG + C F P ++VSG+ D++ R
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 134 bits (336), Expect = 1e-31
Identities = 85/247 (34%), Positives = 130/247 (52%), Gaps = 16/247 (6%)
Query: 59 LGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSR 118
L GHT V +FSP+G AS+S D + +W K + L GH + V++S DS
Sbjct: 37 LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSS 96
Query: 119 QLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRM 178
+L S DK + LWDV+SG+ L+ L GH + + +F+P N + +GS+D TV IW+
Sbjct: 97 RLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWE--- 153
Query: 179 VTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQL----KGHV 233
V + L HS +S + ++ SG L+ SGS+D IW + L L V
Sbjct: 154 VKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPV 213
Query: 234 TWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAF----TPDGKI 289
++VK FSP+ ++ +A +K+WD + G+CL+T G + + C F GK
Sbjct: 214 SFVK---FSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKY-CIFANFSVTGGKW 269
Query: 290 LVSGAAD 296
+VSG+ D
Sbjct: 270 IVSGSED 276
Score = 132 bits (332), Expect = 4e-31
Identities = 83/289 (28%), Positives = 140/289 (48%), Gaps = 16/289 (5%)
Query: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
H V+S FSP+G+ L + S D + W G+ L GH + +S D
Sbjct: 40 HTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLV 99
Query: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
SAS D T++LWDV KCL+ LKGH V +F+P S + SG +D+ V +W+V++G+
Sbjct: 100 SASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKC 159
Query: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQAL----EGHSANI 195
L+ L H D + + F+ + + + +GS+D IWD A S Q L + + +
Sbjct: 160 LKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD------AASGQCLKTLVDDDNPPV 213
Query: 196 SCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDEL----WLAS 250
S + +S +G + + + D T+ +W + L GH K F+ + W+ S
Sbjct: 214 SFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKN-EKYCIFANFSVTGGKWIVS 272
Query: 251 AGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTR 299
+V +W+ T + ++ L+G DV + A P ++ S A + +
Sbjct: 273 GSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDK 321
Score = 95.5 bits (236), Expect = 5e-20
Identities = 53/167 (31%), Positives = 91/167 (54%), Gaps = 6/167 (3%)
Query: 14 VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRL-GGHTGPVKFCRFS 72
+K H V++ F+ G ++++GS DG W+ SGQ L L PV F +FS
Sbjct: 160 LKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFS 219
Query: 73 PDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETV--SFS-PDSRQLASGGWDKRV 129
P+G +A+ D T++LWD +R +CL+ GH+ + +FS + + SG D V
Sbjct: 220 PNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLV 279
Query: 130 MLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSW--DSTVHIW 174
+W++Q+ ++++ L GH D + S+ PT N +A+ + D T+ +W
Sbjct: 280 YIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
Score = 53.1 bits (126), Expect = 3e-07
Identities = 35/136 (25%), Positives = 55/136 (40%), Gaps = 42/136 (30%)
Query: 205 LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMV------- 257
L S S +++ + + +L L GH V S+ FSP+ WLAS+ R++
Sbjct: 13 LALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYD 72
Query: 258 -----------------------------------KVWDCNTGKCLETLKGVLDVAHTCA 282
K+WD +GKCL+TLKG + C
Sbjct: 73 GKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCN 132
Query: 283 FTPDGKILVSGAADQT 298
F P +++SG+ D+T
Sbjct: 133 FNPPSNLIISGSFDET 148
>gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo
sapiens]
Length = 421
Score = 132 bits (332), Expect = 4e-31
Identities = 91/270 (33%), Positives = 134/270 (49%), Gaps = 35/270 (12%)
Query: 29 FSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLF-ASASCDCTV 87
F D +L TG +G + W+ +G+LL L HT V+ F+PDG L SAS D T+
Sbjct: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
Query: 88 RLWDVAR-AKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGH 146
R+WD+ ++VL+GHQ V + +FSPDS L S G K V LW++ M+R L GH
Sbjct: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255
Query: 147 RDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLL 206
+ + DFSP LAT S+D+ V+IWD H+ +I L+
Sbjct: 256 HHDVVACDFSPDGALLATASYDTRVYIWD--------------PHNGDI---------LM 292
Query: 207 ASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGK 266
G H++ P T + + WV+S++FS D L +AS +MV+ W +
Sbjct: 293 EFG------HLFPPPTP--IFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDY 344
Query: 267 CLETLKGVLDVAHTCAFTPDGKILVSGAAD 296
++ L CAF+ DG +L +G D
Sbjct: 345 PVQV--APLSNGLCCAFSTDGSVLAAGTHD 372
Score = 86.3 bits (212), Expect = 3e-17
Identities = 64/224 (28%), Positives = 104/224 (46%), Gaps = 14/224 (6%)
Query: 84 DCTVRLWDVARAKCLRVLKGHQRSVE--TVSFSPDSRQLASGGWDKRVMLWDVQSGQMLR 141
DC +W +A + + ++E F D LA+G + R+ +WDV +G++L
Sbjct: 105 DCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLL 164
Query: 142 LLVGHRDSIQSSDFSPTVNC-LATGSWDSTVHIWDLRMVTPAVSHQALEGHSANI-SCLC 199
LV H + ++ F+P + L + S D T+ +WDL+ + L GH + SC
Sbjct: 165 NLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLK--DDGNMMKVLRGHQNWVYSCAF 222
Query: 200 YSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKV 259
S +L S K + +W +++ +L+GH V + FSPD LA+A Y V +
Sbjct: 223 SPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYI 282
Query: 260 WDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRRQIS 303
WD + G L ++ H F P I GA D+ R +S
Sbjct: 283 WDPHNGDIL------MEFGH--LFPPPTPIFAGGANDRWVRSVS 318
Score = 76.3 bits (186), Expect = 3e-14
Identities = 58/186 (31%), Positives = 78/186 (41%), Gaps = 17/186 (9%)
Query: 14 VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSP 73
+K H V S AFSPD ML + V+ W ++ +L GH V C FSP
Sbjct: 207 MKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSP 266
Query: 74 DGHLFASASCDCTVRLWDVARAKCLRVLKGH--------------QRSVETVSFSPDSRQ 119
DG L A+AS D V +WD L GH R V +VSFS D
Sbjct: 267 DGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLH 325
Query: 120 LASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMV 179
+AS DK V W + ++ V + FS + LA G+ D +V+ W
Sbjct: 326 VASLADDKMVRFWRIDEDYPVQ--VAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQ 383
Query: 180 TPAVSH 185
P++ H
Sbjct: 384 VPSLQH 389
Score = 75.1 bits (183), Expect = 8e-14
Identities = 67/241 (27%), Positives = 109/241 (45%), Gaps = 20/241 (8%)
Query: 71 FSPDGHLFASASCDCTVRLWDVARAKCLRVLKGH-QRSVETVSFSPDSRQLASGGWDKRV 129
F+PDG FA + TV+L V ++CL+ H ++V S RQ + GG +
Sbjct: 42 FAPDGSYFAWSQGHRTVKL--VPWSQCLQNFLLHGTKNVTNSSSLRLPRQNSDGGQKNKP 99
Query: 130 ---------MLWDVQSGQMLRLLVGHRDSIQ--SSDFSPTVNCLATGSWDSTVHIWDLRM 178
++W + G + +I+ F LATG + + IWD+
Sbjct: 100 REHIIDCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYT 159
Query: 179 VTPAVSHQALEGHSANISCLCYSASG--LLASGSWDKTIHIWK-PTTSSLLIQLKGHVTW 235
++ L H+ + L ++ G +L S S DKT+ +W +++ L+GH W
Sbjct: 160 GKLLLN---LVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNW 216
Query: 236 VKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAA 295
V S AFSPD L S G S+ V +W+ + + L+G C F+PDG +L + +
Sbjct: 217 VYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASY 276
Query: 296 D 296
D
Sbjct: 277 D 277
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 130 bits (326), Expect = 2e-30
Identities = 80/206 (38%), Positives = 103/206 (50%), Gaps = 4/206 (1%)
Query: 14 VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSP 73
+K H G V S+ F D LL+ SED + W+ S GH PV SP
Sbjct: 335 MKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISP 394
Query: 74 DGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 133
FAS S D T RLW R LR+ GH V+ V F P+S LA+G DK V LW
Sbjct: 395 YSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWS 454
Query: 134 VQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSA 193
Q G +RL GHR + S FSP LA+ D + +WDL T ++ L GH+
Sbjct: 455 AQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGT---LYKELRGHTD 511
Query: 194 NISCLCYSA-SGLLASGSWDKTIHIW 218
NI+ L +S SGL+AS S D ++ +W
Sbjct: 512 NITSLTFSPDSGLIASASMDNSVRVW 537
Score = 126 bits (317), Expect = 2e-29
Identities = 82/277 (29%), Positives = 118/277 (42%), Gaps = 36/277 (12%)
Query: 24 VNSSAFSPDGQMLLTGSEDGCVYGWETRSGQL---------------------------- 55
+N++ SPD ++L G ++ C+ W RS +L
Sbjct: 271 LNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDN 330
Query: 56 ----LWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETV 111
+ L GH GPV RF D S S D ++R WD+ + +GH V +
Sbjct: 331 AGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDL 390
Query: 112 SFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTV 171
SP S ASG D+ LW LR+ GH + F P N LATGS D TV
Sbjct: 391 DISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTV 450
Query: 172 HIWDLRMVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLK 230
+W + S + GH + L +S +G LAS D+ + +W + +L +L+
Sbjct: 451 RLWSAQQGN---SVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELR 507
Query: 231 GHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKC 267
GH + S+ FSPD +ASA V+VWD C
Sbjct: 508 GHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYC 544
Score = 90.1 bits (222), Expect = 2e-18
Identities = 50/163 (30%), Positives = 79/163 (48%), Gaps = 11/163 (6%)
Query: 14 VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSP 73
++ + H +V+ F P+ L TGS D V W + G + GH GPV FSP
Sbjct: 419 LRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSP 478
Query: 74 DGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 133
+G ASA D ++LWD+A + L+GH ++ +++FSPDS +AS D V +WD
Sbjct: 479 NGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWD 538
Query: 134 VQ-----------SGQMLRLLVGHRDSIQSSDFSPTVNCLATG 165
++ S +++ + G ++ S F L TG
Sbjct: 539 IRNTYCSAPADGSSSELVGVYTGQMSNVLSVQFMACNLLLVTG 581
Score = 85.9 bits (211), Expect = 4e-17
Identities = 69/269 (25%), Positives = 115/269 (42%), Gaps = 50/269 (18%)
Query: 72 SPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVML 131
SPD L A+ + ++LW + R+K L+ + HQ V + + D +
Sbjct: 277 SPDSKLLAAGFDNSCIKLWSL-RSKKLKS-EPHQVDVSRIHLACDILEEEDDE------- 327
Query: 132 WDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQA---- 187
D +G +++L GH + S+ F + L + S D ++ WDL T V +Q
Sbjct: 328 -DDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYP 386
Query: 188 -----------------------------------LEGHSANISCLCYSA-SGLLASGSW 211
GH A++ C+ + S LA+GS
Sbjct: 387 VWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGST 446
Query: 212 DKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETL 271
DKT+ +W + + GH V S+AFSP+ +LASAG + +K+WD +G + L
Sbjct: 447 DKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKEL 506
Query: 272 KGVLDVAHTCAFTPDGKILVSGAADQTRR 300
+G D + F+PD ++ S + D + R
Sbjct: 507 RGHTDNITSLTFSPDSGLIASASMDNSVR 535
Score = 45.1 bits (105), Expect = 8e-05
Identities = 45/182 (24%), Positives = 70/182 (38%), Gaps = 32/182 (17%)
Query: 150 IQSSDFSPTVNCLATGSWDSTVHIWDLR---------MVTPAVSHQA------------- 187
+ +++ SP LA G +S + +W LR V + H A
Sbjct: 271 LNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDN 330
Query: 188 -------LEGHSANISCLCYSA--SGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKS 238
L GH + + A SGLL S S D +I W + + + +GH V
Sbjct: 331 AGTEMKILRGHCGPVYSTRFLADSSGLL-SCSEDMSIRYWDLGSFTNTVLYQGHAYPVWD 389
Query: 239 IAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQT 298
+ SP L+ AS + R ++W + L G L F P+ L +G+ D+T
Sbjct: 390 LDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKT 449
Query: 299 RR 300
R
Sbjct: 450 VR 451
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 130 bits (326), Expect = 2e-30
Identities = 85/286 (29%), Positives = 135/286 (47%), Gaps = 10/286 (3%)
Query: 15 KFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPD 74
++F H + S SP+G+ L T S D + W + +R GH V +FSP
Sbjct: 12 RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH 71
Query: 75 GHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDV 134
G+L ASAS D TVRLW + K H V +V FS D + LA+ DK + +W +
Sbjct: 72 GNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSM 131
Query: 135 QSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSAN 194
+ L L H ++ + FSP + + S D T+ IWD + Q + S +
Sbjct: 132 YRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWD------TTNKQCVNNFSDS 185
Query: 195 I---SCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLAS 250
+ + + ++ SG +AS D+T+ +W + LL + H V I+F P +L +
Sbjct: 186 VGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLIT 245
Query: 251 AGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAAD 296
A +K+ D G+ + TL+G T +F+ G++ SG AD
Sbjct: 246 ASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGAD 291
Score = 122 bits (305), Expect = 5e-28
Identities = 64/201 (31%), Positives = 99/201 (49%), Gaps = 4/201 (1%)
Query: 99 RVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPT 158
R KGH+ ++ ++ SP+ +QLA+ WD +MLW+ + VGH+D + S FSP
Sbjct: 12 RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH 71
Query: 159 VNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHI 217
N LA+ S D TV +W + + H+A + + +SA G LA+ S DK+I +
Sbjct: 72 GNLLASASRDRTVRLW---IPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKV 128
Query: 218 WKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDV 277
W L L H WV+ FSPD + S + +K+WD +C+ +
Sbjct: 129 WSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGF 188
Query: 278 AHTCAFTPDGKILVSGAADQT 298
A+ F P G + S +DQT
Sbjct: 189 ANFVDFNPSGTCIASAGSDQT 209
Score = 120 bits (302), Expect = 1e-27
Identities = 79/253 (31%), Positives = 116/253 (45%), Gaps = 5/253 (1%)
Query: 12 RRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRF 71
R ++ G H V S FSP G +L + S D V W HT PV+ F
Sbjct: 52 RAYRYVG-HKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDF 110
Query: 72 SPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVML 131
S DG A+AS D ++++W + R + L L H V FSPD R + S DK + +
Sbjct: 111 SADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKI 170
Query: 132 WDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGH 191
WD + Q + DF+P+ C+A+ D TV +WD+R V + H + H
Sbjct: 171 WDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVR-VNKLLQHYQV--H 227
Query: 192 SANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLAS 250
S ++C+ + SG L + S D T+ I L+ L+GH V +++FS AS
Sbjct: 228 SGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFAS 287
Query: 251 AGYSRMVKVWDCN 263
G V +W N
Sbjct: 288 GGADTQVLLWRTN 300
Score = 115 bits (287), Expect = 7e-26
Identities = 73/220 (33%), Positives = 105/220 (47%), Gaps = 12/220 (5%)
Query: 12 RRVKF--FGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFC 69
+R KF F H V S FS DGQ L T SED + W + L+ L HT V+
Sbjct: 91 KRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCA 150
Query: 70 RFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRV 129
+FSPDG L S S D T+++WD +C+ V F+P +AS G D+ V
Sbjct: 151 KFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTV 210
Query: 130 MLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDL---RMVTPAVSHQ 186
+WDV+ ++L+ H + F P+ N L T S D T+ I DL R++
Sbjct: 211 KVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLI------Y 264
Query: 187 ALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSL 225
L+GH+ + + +S G L ASG D + +W+ L
Sbjct: 265 TLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDEL 304
Score = 106 bits (264), Expect = 3e-23
Identities = 74/240 (30%), Positives = 108/240 (45%), Gaps = 6/240 (2%)
Query: 61 GHTGPVKFCRFSPDGHLFASASCDCTVRLWDVA-RAKCLRVLKGHQRSVETVSFSPDSRQ 119
GH + SP+G A+AS D + LW+ A+ R + GH+ V +V FSP
Sbjct: 16 GHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYV-GHKDVVTSVQFSPHGNL 74
Query: 120 LASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMV 179
LAS D+ V LW H ++S DFS LAT S D ++ +W +
Sbjct: 75 LASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQ 134
Query: 180 TPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKS 238
S L H+ + C +S G L+ S S DKTI IW T + V +
Sbjct: 135 RFLYS---LYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANF 191
Query: 239 IAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQT 298
+ F+P +ASAG + VKVWD K L+ + + +F P G L++ ++D T
Sbjct: 192 VDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGT 251
Score = 90.9 bits (224), Expect = 1e-18
Identities = 54/168 (32%), Positives = 85/168 (50%), Gaps = 4/168 (2%)
Query: 141 RLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCY 200
R GH+ +I S D SP LAT SWD+ + +W+ + P GH ++ + +
Sbjct: 12 RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFK---PHARAYRYVGHKDVVTSVQF 68
Query: 201 SASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKV 259
S G LLAS S D+T+ +W P + K H V+S+ FS D +LA+A + +KV
Sbjct: 69 SPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKV 128
Query: 260 WDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRRQISRTSK 307
W + L +L F+PDG+++VS + D+T + T+K
Sbjct: 129 WSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNK 176
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 125 bits (315), Expect = 4e-29
Identities = 84/284 (29%), Positives = 127/284 (44%), Gaps = 4/284 (1%)
Query: 15 KFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPD 74
+ F H V FS + + L +GS D C+ W + +R GH V FSP
Sbjct: 13 RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72
Query: 75 GHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDV 134
GHL AS S D TVR+W V + H +V +V F D + + DK V +W
Sbjct: 73 GHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWAT 132
Query: 135 QSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSAN 194
+ L L H + ++ + FSP + + S D TV +WD + H E H
Sbjct: 133 HRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD--KSSRECVHSYCE-HGGF 189
Query: 195 ISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGY 253
++ + + SG +A+ D T+ +W T LL + H V ++F P +L +A
Sbjct: 190 VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASS 249
Query: 254 SRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQ 297
+K+ D G+ L TL G A T AF+ G+ SG +D+
Sbjct: 250 DSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDE 293
Score = 125 bits (313), Expect = 6e-29
Identities = 88/258 (34%), Positives = 118/258 (45%), Gaps = 15/258 (5%)
Query: 12 RRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGW--ETRSGQLLWRLGGHTGPVKFC 69
R +F G H V FSP G +L +GS D V W + ++R HT V+
Sbjct: 53 RAYRFTG-HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFR--AHTATVRSV 109
Query: 70 RFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRV 129
F DG F +AS D TV++W R K L L H V FSPD R + S DK V
Sbjct: 110 HFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTV 169
Query: 130 MLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALE 189
LWD S + + H + DF P+ C+A D+TV +WD+R +H+ L+
Sbjct: 170 KLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR------THRLLQ 223
Query: 190 G---HSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDE 245
HSA ++ L + SG L + S D T+ I LL L GH ++AFS
Sbjct: 224 HYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTG 283
Query: 246 LWLASAGYSRMVKVWDCN 263
+ AS G V VW N
Sbjct: 284 EYFASGGSDEQVMVWKSN 301
Score = 108 bits (271), Expect = 5e-24
Identities = 62/203 (30%), Positives = 100/203 (49%), Gaps = 8/203 (3%)
Query: 99 RVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPT 158
R KGH+ +V V FS +++QLASG D +M+W ++ GH+D++ +FSP+
Sbjct: 13 RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72
Query: 159 VNCLATGSWDSTVHIWDLRMVTPAVSHQA--LEGHSANISCLCYSASG-LLASGSWDKTI 215
+ LA+GS D TV IW P V ++ H+A + + + + G + S DKT+
Sbjct: 73 GHLLASGSRDKTVRIW-----VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTV 127
Query: 216 HIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVL 275
+W L L H+ WV+ FSPD + SA + VK+WD ++ +C+ +
Sbjct: 128 KVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHG 187
Query: 276 DVAHTCAFTPDGKILVSGAADQT 298
F P G + + D T
Sbjct: 188 GFVTYVDFHPSGTCIAAAGMDNT 210
Score = 97.4 bits (241), Expect = 1e-20
Identities = 55/164 (33%), Positives = 86/164 (52%), Gaps = 4/164 (2%)
Query: 145 GHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG 204
GHRD++ DFS LA+GS DS + +W ++ P GH ++C+ +S SG
Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMK---PQSRAYRFTGHKDAVTCVNFSPSG 73
Query: 205 -LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCN 263
LLASGS DKT+ IW P + H V+S+ F D +A + VKVW +
Sbjct: 74 HLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATH 133
Query: 264 TGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRRQISRTSK 307
K L +L ++ F+PDG+++VS + D+T + ++S+
Sbjct: 134 RQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR 177
Score = 35.8 bits (81), Expect = 0.051
Identities = 24/77 (31%), Positives = 31/77 (40%)
Query: 224 SLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAF 283
SL KGH V + FS + LAS + VW G D F
Sbjct: 10 SLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNF 69
Query: 284 TPDGKILVSGAADQTRR 300
+P G +L SG+ D+T R
Sbjct: 70 SPSGHLLASGSRDKTVR 86
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 125 bits (315), Expect = 4e-29
Identities = 84/284 (29%), Positives = 127/284 (44%), Gaps = 4/284 (1%)
Query: 15 KFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPD 74
+ F H V FS + + L +GS D C+ W + +R GH V FSP
Sbjct: 13 RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72
Query: 75 GHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDV 134
GHL AS S D TVR+W V + H +V +V F D + + DK V +W
Sbjct: 73 GHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWAT 132
Query: 135 QSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSAN 194
+ L L H + ++ + FSP + + S D TV +WD + H E H
Sbjct: 133 HRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD--KSSRECVHSYCE-HGGF 189
Query: 195 ISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGY 253
++ + + SG +A+ D T+ +W T LL + H V ++F P +L +A
Sbjct: 190 VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASS 249
Query: 254 SRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQ 297
+K+ D G+ L TL G A T AF+ G+ SG +D+
Sbjct: 250 DSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDE 293
Score = 125 bits (313), Expect = 6e-29
Identities = 88/258 (34%), Positives = 118/258 (45%), Gaps = 15/258 (5%)
Query: 12 RRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGW--ETRSGQLLWRLGGHTGPVKFC 69
R +F G H V FSP G +L +GS D V W + ++R HT V+
Sbjct: 53 RAYRFTG-HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFR--AHTATVRSV 109
Query: 70 RFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRV 129
F DG F +AS D TV++W R K L L H V FSPD R + S DK V
Sbjct: 110 HFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTV 169
Query: 130 MLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALE 189
LWD S + + H + DF P+ C+A D+TV +WD+R +H+ L+
Sbjct: 170 KLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR------THRLLQ 223
Query: 190 G---HSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDE 245
HSA ++ L + SG L + S D T+ I LL L GH ++AFS
Sbjct: 224 HYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTG 283
Query: 246 LWLASAGYSRMVKVWDCN 263
+ AS G V VW N
Sbjct: 284 EYFASGGSDEQVMVWKSN 301
Score = 108 bits (271), Expect = 5e-24
Identities = 62/203 (30%), Positives = 100/203 (49%), Gaps = 8/203 (3%)
Query: 99 RVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPT 158
R KGH+ +V V FS +++QLASG D +M+W ++ GH+D++ +FSP+
Sbjct: 13 RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72
Query: 159 VNCLATGSWDSTVHIWDLRMVTPAVSHQA--LEGHSANISCLCYSASG-LLASGSWDKTI 215
+ LA+GS D TV IW P V ++ H+A + + + + G + S DKT+
Sbjct: 73 GHLLASGSRDKTVRIW-----VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTV 127
Query: 216 HIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVL 275
+W L L H+ WV+ FSPD + SA + VK+WD ++ +C+ +
Sbjct: 128 KVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHG 187
Query: 276 DVAHTCAFTPDGKILVSGAADQT 298
F P G + + D T
Sbjct: 188 GFVTYVDFHPSGTCIAAAGMDNT 210
Score = 97.4 bits (241), Expect = 1e-20
Identities = 55/164 (33%), Positives = 86/164 (52%), Gaps = 4/164 (2%)
Query: 145 GHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG 204
GHRD++ DFS LA+GS DS + +W ++ P GH ++C+ +S SG
Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMK---PQSRAYRFTGHKDAVTCVNFSPSG 73
Query: 205 -LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCN 263
LLASGS DKT+ IW P + H V+S+ F D +A + VKVW +
Sbjct: 74 HLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATH 133
Query: 264 TGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRRQISRTSK 307
K L +L ++ F+PDG+++VS + D+T + ++S+
Sbjct: 134 RQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR 177
Score = 35.8 bits (81), Expect = 0.051
Identities = 24/77 (31%), Positives = 31/77 (40%)
Query: 224 SLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAF 283
SL KGH V + FS + LAS + VW G D F
Sbjct: 10 SLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNF 69
Query: 284 TPDGKILVSGAADQTRR 300
+P G +L SG+ D+T R
Sbjct: 70 SPSGHLLASGSRDKTVR 86
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 125 bits (315), Expect = 4e-29
Identities = 96/326 (29%), Positives = 145/326 (44%), Gaps = 48/326 (14%)
Query: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
H V S AFSP G+ L +GS D V W+ + + GH V +SPDG A
Sbjct: 113 HSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLA 172
Query: 80 SASCDCTVRLWDVARAKCL-RVLKGHQR-----SVETVSFSPDSRQLASGGWDKRVMLWD 133
S + + LWD + K + R L GH + S E + +P+ R +AS D V +WD
Sbjct: 173 SGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWD 232
Query: 134 VQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIW------------------- 174
+G+ R+L GH S+ + L + S D T+ +W
Sbjct: 233 TTAGRCERILTGHTQSVTCLRWGGD-GLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVN 291
Query: 175 ------DLRMVTPA-------VSHQALEGHSANISCLCYSASGL--------LASGSWDK 213
D + T A V+ Q L+G + S L L SGS D
Sbjct: 292 TMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDF 351
Query: 214 TIHIWKPTTSSL-LIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLK 272
T+ +W P L ++ GH + + FSPD +ASA + + +K+WD TGK L +L+
Sbjct: 352 TLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLR 411
Query: 273 GVLDVAHTCAFTPDGKILVSGAADQT 298
G + + A++ D ++LVSG++D T
Sbjct: 412 GHVAAVYQIAWSADSRLLVSGSSDST 437
Score = 120 bits (301), Expect = 2e-27
Identities = 72/192 (37%), Positives = 103/192 (53%), Gaps = 9/192 (4%)
Query: 59 LGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSR 118
L GH+ V FSP G AS S D TVR WD++ KGH+ V ++S+SPD R
Sbjct: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGR 169
Query: 119 QLASGGWDKRVMLWDVQSG-QMLRLLVGHRDSIQSSDF-----SPTVNCLATGSWDSTVH 172
+LASG + +++LWD +G Q+ R L GH I + +P +A+ S D +V
Sbjct: 170 KLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVR 229
Query: 173 IWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGH 232
IWD T + L GH+ +++CL + GLL S S D+TI +W+ L L+GH
Sbjct: 230 IWD---TTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGH 286
Query: 233 VTWVKSIAFSPD 244
WV ++A S D
Sbjct: 287 GHWVNTMALSTD 298
Score = 120 bits (301), Expect = 2e-27
Identities = 96/333 (28%), Positives = 151/333 (45%), Gaps = 58/333 (17%)
Query: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWR-LGGHTGPVKFCRF-----SP 73
H V S ++SPDG+ L +G ++G + W+ +G+ + R L GH+ + + +P
Sbjct: 155 HRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANP 214
Query: 74 DGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 133
+ AS+S D +VR+WD +C R+L GH +SV + + D L S D+ + +W
Sbjct: 215 ECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGL-LYSASQDRTIKVWR 273
Query: 134 VQSGQMLRLLVGHRD-----------SIQSSDFSP---TVNC------------------ 161
G + R L GH ++++ F P +VN
Sbjct: 274 AHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRY 333
Query: 162 ----------LATGSWDSTVHIWDLRMVTPAVSHQALE---GHSANISCLCYSA-SGLLA 207
L +GS D T+ +W +PA + L GH A I+ + +S S ++A
Sbjct: 334 NLVRGQGPERLVSGSDDFTLFLW-----SPAEDKKPLTRMTGHQALINQVLFSPDSRIVA 388
Query: 208 SGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKC 267
S S+DK+I +W T L L+GHV V IA+S D L S +KVWD K
Sbjct: 389 SASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKL 448
Query: 268 LETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
L G D + ++PDG+ + SG D+ R
Sbjct: 449 AMDLPGHADEVYAVDWSPDGQRVASGGKDKCLR 481
Score = 103 bits (256), Expect = 3e-22
Identities = 78/275 (28%), Positives = 121/275 (44%), Gaps = 48/275 (17%)
Query: 30 SPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRL 89
+P+ + + + S+DG V W+T +G+ L GHT V R+ DG L+ SAS D T+++
Sbjct: 213 NPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLY-SASQDRTIKV 271
Query: 90 WDVARAKCLRVLKGHQRSVETVSFSPD--------------------------------- 116
W R L+GH V T++ S D
Sbjct: 272 WRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALS 331
Query: 117 ---------SRQLASGGWDKRVMLWD-VQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGS 166
+L SG D + LW + + L + GH+ I FSP +A+ S
Sbjct: 332 RYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASAS 391
Query: 167 WDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSA-SGLLASGSWDKTIHIWKPTTSSL 225
+D ++ +WD R S L GH A + + +SA S LL SGS D T+ +W L
Sbjct: 392 FDKSIKLWDGRTGKYLAS---LRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKL 448
Query: 226 LIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVW 260
+ L GH V ++ +SPD +AS G + +++W
Sbjct: 449 AMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 86.7 bits (213), Expect = 3e-17
Identities = 53/142 (37%), Positives = 78/142 (54%), Gaps = 5/142 (3%)
Query: 80 SASCDCTVRLWDVAR-AKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQ 138
S S D T+ LW A K L + GHQ + V FSPDSR +AS +DK + LWD ++G+
Sbjct: 346 SGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGK 405
Query: 139 MLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCL 198
L L GH ++ +S L +GS DST+ +WD++ A+ L GH+ + +
Sbjct: 406 YLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMD---LPGHADEVYAV 462
Query: 199 CYSASG-LLASGSWDKTIHIWK 219
+S G +ASG DK + IW+
Sbjct: 463 DWSPDGQRVASGGKDKCLRIWR 484
Score = 84.3 bits (207), Expect = 1e-16
Identities = 64/203 (31%), Positives = 91/203 (44%), Gaps = 15/203 (7%)
Query: 93 ARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQS 152
A +C L+GH +V +V+FSP + LASG D V WD+ + GHR + S
Sbjct: 102 AVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLS 161
Query: 153 SDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQ---ALEGHSANISCLCYS------AS 203
+SP LA+G + + +WD P+ Q L GHS I+ L +
Sbjct: 162 ISWSPDGRKLASGCKNGQILLWD-----PSTGKQVGRTLAGHSKWITGLSWEPLHANPEC 216
Query: 204 GLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCN 263
+AS S D ++ IW T L GH V + + D L L SA R +KVW +
Sbjct: 217 RYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGL-LYSASQDRTIKVWRAH 275
Query: 264 TGKCLETLKGVLDVAHTCAFTPD 286
G TL+G +T A + D
Sbjct: 276 DGVLCRTLQGHGHWVNTMALSTD 298
Score = 82.4 bits (202), Expect = 5e-16
Identities = 42/113 (37%), Positives = 61/113 (53%)
Query: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
H +N FSPD +++ + S D + W+ R+G+ L L GH V +S D L
Sbjct: 371 HQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLV 430
Query: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLW 132
S S D T+++WDV K L GH V V +SPD +++ASGG DK + +W
Sbjct: 431 SGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 44.3 bits (103), Expect = 1e-04
Identities = 29/85 (34%), Positives = 42/85 (49%), Gaps = 8/85 (9%)
Query: 229 LKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGK 288
L+GH V S+AFSP +LAS V+ WD +T T KG + +++PDG+
Sbjct: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGR 169
Query: 289 ILVSGAAD--------QTRRQISRT 305
L SG + T +Q+ RT
Sbjct: 170 KLASGCKNGQILLWDPSTGKQVGRT 194
Score = 32.7 bits (73), Expect = 0.43
Identities = 15/44 (34%), Positives = 26/44 (59%)
Query: 266 KCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRRQISRTSKSP 309
+C +L+G + + AF+P GK L SG+ D T R ++++P
Sbjct: 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETP 148
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 125 bits (313), Expect = 6e-29
Identities = 88/258 (34%), Positives = 118/258 (45%), Gaps = 15/258 (5%)
Query: 12 RRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGW--ETRSGQLLWRLGGHTGPVKFC 69
R +F G H V FSP G +L +GS D V W + ++R HT V+
Sbjct: 15 RAYRFTG-HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFR--AHTATVRSV 71
Query: 70 RFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRV 129
F DG F +AS D TV++W R K L L H V FSPD R + S DK V
Sbjct: 72 HFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTV 131
Query: 130 MLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALE 189
LWD S + + H + DF P+ C+A D+TV +WD+R +H+ L+
Sbjct: 132 KLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR------THRLLQ 185
Query: 190 G---HSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDE 245
HSA ++ L + SG L + S D T+ I LL L GH ++AFS
Sbjct: 186 HYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTG 245
Query: 246 LWLASAGYSRMVKVWDCN 263
+ AS G V VW N
Sbjct: 246 EYFASGGSDEQVMVWKSN 263
Score = 116 bits (290), Expect = 3e-26
Identities = 76/257 (29%), Positives = 115/257 (44%), Gaps = 4/257 (1%)
Query: 42 DGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVL 101
D C+ W + +R GH V FSP GHL AS S D TVR+W V
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
Query: 102 KGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNC 161
+ H +V +V F D + + DK V +W + L L H + ++ + FSP
Sbjct: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121
Query: 162 LATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGL-LASGSWDKTIHIWKP 220
+ + S D TV +WD + H E H ++ + + SG +A+ D T+ +W
Sbjct: 122 IVSASDDKTVKLWDKS--SRECVHSYCE-HGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 178
Query: 221 TTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHT 280
T LL + H V ++F P +L +A +K+ D G+ L TL G A T
Sbjct: 179 RTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATT 238
Query: 281 CAFTPDGKILVSGAADQ 297
AF+ G+ SG +D+
Sbjct: 239 VAFSRTGEYFASGGSDE 255
Score = 85.9 bits (211), Expect = 4e-17
Identities = 59/216 (27%), Positives = 92/216 (42%), Gaps = 4/216 (1%)
Query: 84 DCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLL 143
D + +W + GH+ +V V+FSP LASG DK V +W +
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
Query: 144 VGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSAS 203
H +++S F T S D TV +W S L H + C +S
Sbjct: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFS---LSQHINWVRCAKFSPD 118
Query: 204 G-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDC 262
G L+ S S DKT+ +W ++ + H +V + F P +A+AG VKVWD
Sbjct: 119 GRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 178
Query: 263 NTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQT 298
T + L+ + + +F P G L++ ++D T
Sbjct: 179 RTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDST 214
Score = 77.0 bits (188), Expect = 2e-14
Identities = 44/141 (31%), Positives = 72/141 (51%), Gaps = 4/141 (2%)
Query: 168 DSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLL 226
DS + +W ++ P GH ++C+ +S SG LLASGS DKT+ IW P
Sbjct: 2 DSCLMVWHMK---PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGES 58
Query: 227 IQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPD 286
+ H V+S+ F D +A + VKVW + K L +L ++ F+PD
Sbjct: 59 TVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPD 118
Query: 287 GKILVSGAADQTRRQISRTSK 307
G+++VS + D+T + ++S+
Sbjct: 119 GRLIVSASDDKTVKLWDKSSR 139
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 123 bits (309), Expect = 2e-28
Identities = 72/239 (30%), Positives = 122/239 (51%), Gaps = 8/239 (3%)
Query: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDG-HLF 78
H G V ++ DG ML + S D V W++ +G+ + RL GHT V C + G L
Sbjct: 108 HSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLV 167
Query: 79 ASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQ 138
+ S D TV+LWD+ + ++ + + V V+F+ S Q+ SGG D + +WD++ +
Sbjct: 168 CTGSDDGTVKLWDIRKKAAIQTFQNTYQ-VLAVTFNDTSDQIISGGIDNDIKVWDLRQNK 226
Query: 139 MLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTP-----AVSHQALEGHSA 193
+ + GH DS+ S + L + + D+TV +WD+R P + +
Sbjct: 227 LTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEK 286
Query: 194 NISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASA 251
N+ +S G +A+GS D+ +++W T+ +L +L GH + +AF PDE + SA
Sbjct: 287 NLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISA 345
Score = 110 bits (274), Expect = 2e-24
Identities = 72/251 (28%), Positives = 117/251 (46%), Gaps = 17/251 (6%)
Query: 59 LGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDV-ARAKCLRVLKGHQRSVETVSFSPDS 117
L GH G V C+F P+G ASA D + LW+V LKGH +V + ++ D
Sbjct: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDG 121
Query: 118 RQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQS---SDFSPTVNCLATGSWDSTVHIW 174
L S DK V +WD ++G+ ++ L GH + S + P + C TGS D TV +W
Sbjct: 122 SMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVC--TGSDDGTVKLW 179
Query: 175 DLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVT 234
D+R + Q + ++ S + SG D I +W + L ++GH
Sbjct: 180 DIR---KKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHAD 236
Query: 235 WVKSIAFSPDELWLASAGYSRMVKVWDCN----TGKCLETLKGVLDVAH----TCAFTPD 286
V ++ S + +L S V+VWD +C++ +G + C+++PD
Sbjct: 237 SVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPD 296
Query: 287 GKILVSGAADQ 297
G + +G+AD+
Sbjct: 297 GSKIAAGSADR 307
Score = 83.2 bits (204), Expect = 3e-16
Identities = 57/207 (27%), Positives = 95/207 (45%), Gaps = 9/207 (4%)
Query: 98 LRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSG-QMLRLLVGHRDSIQSSDFS 156
+ +L GH+ V F P+ LAS G+D+ ++LW+V L GH ++ ++
Sbjct: 59 IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYN 118
Query: 157 PTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG---LLASGSWDK 213
+ L + S D TV +WD + L+GH++ ++ CY A L+ +GS D
Sbjct: 119 TDGSMLFSASTDKTVAVWDSETGERV---KRLKGHTSFVNS-CYPARRGPQLVCTGSDDG 174
Query: 214 TIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKG 273
T+ +W IQ + V ++ F+ + S G +KVWD K T++G
Sbjct: 175 TVKLWD-IRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRG 233
Query: 274 VLDVAHTCAFTPDGKILVSGAADQTRR 300
D + + +G L+S A D T R
Sbjct: 234 HADSVTGLSLSSEGSYLLSNAMDNTVR 260
Score = 79.3 bits (194), Expect = 4e-15
Identities = 45/167 (26%), Positives = 84/167 (50%), Gaps = 8/167 (4%)
Query: 19 QHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLF 78
Q+ +V + F+ +++G D + W+ R +L + + GH V S +G
Sbjct: 191 QNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYL 250
Query: 79 ASASCDCTVRLWDVA----RAKCLRVLKGHQRSVET----VSFSPDSRQLASGGWDKRVM 130
S + D TVR+WDV + +C+++ +G+ + E S+SPD ++A+G D+ V
Sbjct: 251 LSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVY 310
Query: 131 LWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLR 177
+WD S ++L L GH SI F P + + S D +++ +++
Sbjct: 311 VWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357
Score = 53.1 bits (126), Expect = 3e-07
Identities = 31/77 (40%), Positives = 41/77 (53%), Gaps = 4/77 (5%)
Query: 12 RRVKFF--GQHGGEVN--SSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVK 67
R VK F H E N ++SPDG + GS D VY W+T S ++L++L GH G +
Sbjct: 272 RCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSIN 331
Query: 68 FCRFSPDGHLFASASCD 84
F PD + SAS D
Sbjct: 332 EVAFHPDEPIIISASSD 348
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 122 bits (307), Expect = 3e-28
Identities = 79/241 (32%), Positives = 117/241 (48%), Gaps = 6/241 (2%)
Query: 59 LGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSR 118
+ GH G V+ P F + S D T+++WD+A K L GH +V V S S
Sbjct: 200 ISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSP 259
Query: 119 QLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRM 178
L S G DK+V WD++ +++R GH ++ D PT++ L T S DST IWD+R
Sbjct: 260 YLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVR- 318
Query: 179 VTPAVSHQALEGHSANISCL-CYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVK 237
T A H L GH+ ++ + C +A + +GS D TI +W + L H V+
Sbjct: 319 -TKASVH-TLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVR 376
Query: 238 SIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQ 297
++ P AS G +K W G ++ L G + +T DG +LVSGA +
Sbjct: 377 AVVLHPRHYTFAS-GSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDG-VLVSGADNG 434
Query: 298 T 298
T
Sbjct: 435 T 435
Score = 95.1 bits (235), Expect = 7e-20
Identities = 77/288 (26%), Positives = 120/288 (41%), Gaps = 14/288 (4%)
Query: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
H G V A P Q +TGS D + W+ SG+L L GH V+ S
Sbjct: 203 HLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLF 262
Query: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
S D V+ WD+ K +R GH +V + P L + D +WDV++
Sbjct: 263 SCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKAS 322
Query: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANI-SCL 198
+ L GH +++ + + TGS D+T+ +WDL + L H ++ + +
Sbjct: 323 VHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDL---VAGKTRVTLTNHKKSVRAVV 379
Query: 199 CYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVK 258
+ ASGS D I WK S + L GH + ++ + D + ++ A M
Sbjct: 380 LHPRHYTFASGSPD-NIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTM-H 437
Query: 259 VWDCNTGKCLETL-----KGVLDV---AHTCAFTPDGKILVSGAADQT 298
+WD TG + + G LD CAF L++ AD+T
Sbjct: 438 LWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKT 485
Score = 79.7 bits (195), Expect = 3e-15
Identities = 60/215 (27%), Positives = 90/215 (41%), Gaps = 14/215 (6%)
Query: 14 VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSP 73
++ + H V P +L+T S D W+ R+ + L GHT V R
Sbjct: 281 IRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQA 340
Query: 74 DGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 133
+ S D T+RLWD+ K L H++SV V P ASG D + W
Sbjct: 341 AEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPD-NIKQWK 399
Query: 134 VQSGQMLRLLVGHRDSIQSSDFSPTVN---CLATGSWDSTVHIWDLR------MVTPAVS 184
G ++ L GH I + TVN L +G+ + T+H+WD R V AV
Sbjct: 400 FPDGSFIQNLSGHNAIINTL----TVNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQ 455
Query: 185 HQALEGHSANISCLCYSASGLLASGSWDKTIHIWK 219
+L+ S +C + L + DKTI +++
Sbjct: 456 PGSLDSESGIFACAFDQSESRLLTAEADKTIKVYR 490
Score = 58.2 bits (139), Expect = 1e-08
Identities = 32/117 (27%), Positives = 52/117 (44%), Gaps = 1/117 (0%)
Query: 185 HQALEGHSANISCLCYSASGL-LASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSP 243
++ + GH + C+ +GS D+TI IW + L + L GH++ V+ + S
Sbjct: 197 YRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVST 256
Query: 244 DELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
+L S G + VK WD K + G L + P +LV+ + D T R
Sbjct: 257 RSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTAR 313
>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
sapiens]
Length = 472
Score = 122 bits (306), Expect = 4e-28
Identities = 73/238 (30%), Positives = 121/238 (50%), Gaps = 10/238 (4%)
Query: 32 DGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASA-SCDCTVRLW 90
D ++ S D V W+ +G+LLW++ T V C+FSPDG S D + +
Sbjct: 156 DSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVS-CKFSPDGKYVVSGFDVDHGICIM 214
Query: 91 DVARAKCLRVLKGHQ-RSVETVSFSPDSRQLASGGWDKRVMLWDVQS-GQMLRLLVGHRD 148
D + V+K H RS+ + F PDS+++AS D+ + +WDV S +L + H +
Sbjct: 215 DAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSN 274
Query: 149 SIQSSDFSPTVNCLATGSWDSTVHIWDLR---MVTPAVSHQALEGHSANISCLCYSA--S 203
+I + F+ + + L T SWD + IW++ ++GH ++S C+ A S
Sbjct: 275 AISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSS-CHFARDS 333
Query: 204 GLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWD 261
L SG +D+T+ IW + LKGH WV +A S ++ W+ SA R +++W+
Sbjct: 334 SFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWN 391
Score = 110 bits (274), Expect = 2e-24
Identities = 87/296 (29%), Positives = 134/296 (45%), Gaps = 13/296 (4%)
Query: 15 KFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHT-GPVKFCRFSP 73
K H V++ F D LL+GS D V W+ G ++ PV C +
Sbjct: 96 KILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITG 155
Query: 74 DGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASG-GWDKRVMLW 132
D +AS D TVR WD+ K L ++ + + + FSPD + + SG D + +
Sbjct: 156 DSSRVIAASYDKTVRAWDLETGKLLWKVR-YDTFIVSCKFSPDGKYVVSGFDVDHGICIM 214
Query: 133 DVQSGQMLRLLVGHRD-SIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGH 191
D ++ + ++ H SI S F P +A+ S D + IWD+ + A + H
Sbjct: 215 DAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDV--TSQATLLTITKAH 272
Query: 192 SANISCLCYSASG-LLASGSWDKTIHIWKPTTSSL------LIQLKGHVTWVKSIAFSPD 244
S IS C++ SG L + SWDK + IW T + ++GH V S F+ D
Sbjct: 273 SNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARD 332
Query: 245 ELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
+L S G+ R V +WD G +LKG D A + + K ++S + D+T R
Sbjct: 333 SSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMR 388
Score = 92.4 bits (228), Expect = 5e-19
Identities = 49/167 (29%), Positives = 82/167 (49%), Gaps = 7/167 (4%)
Query: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWE-TRSGQLLWRLGGHTGPVKFCRFSPDGHLF 78
H + S F PD Q + + S D C+ W+ T LL H+ + C F+ GH
Sbjct: 229 HTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFL 288
Query: 79 ASASCDCTVRLWDVARAK------CLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLW 132
++S D +++W+V + C+ +++GH+ SV + F+ DS L SGG+D+ V +W
Sbjct: 289 CTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIW 348
Query: 133 DVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMV 179
DV G L GH D + S + + S D T+ +W++ +
Sbjct: 349 DVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIEEI 395
Score = 64.7 bits (156), Expect = 1e-10
Identities = 36/137 (26%), Positives = 63/137 (45%), Gaps = 6/137 (4%)
Query: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQL------LWRLGGHTGPVKFCRFSP 73
H +++ F+ G L T S D + W +G+ + + GH G V C F+
Sbjct: 272 HSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFAR 331
Query: 74 DGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 133
D S D TV +WDVA LKGH V V+ S + + + S D+ + LW+
Sbjct: 332 DSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWN 391
Query: 134 VQSGQMLRLLVGHRDSI 150
++ + L++ ++ ++
Sbjct: 392 IEEIDEIPLVIKYKKAV 408
>gi|13376840 WD repeat domain 61 [Homo sapiens]
Length = 305
Score = 122 bits (305), Expect = 5e-28
Identities = 88/269 (32%), Positives = 134/269 (49%), Gaps = 6/269 (2%)
Query: 32 DGQMLLTGSEDGCVYGWETRSGQL--LWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRL 89
+ + ++TGS D V W+ R +L W L GH V S + AS+S D +RL
Sbjct: 31 NSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRL 90
Query: 90 WDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDS 149
WD+ K ++ + T++FSPDS+ LA+G +V ++ V+SG+ L
Sbjct: 91 WDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKF 150
Query: 150 IQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSA-SGLLAS 208
I S +SP LA+G+ D ++I+D+ T + H LEGH+ I L +S S LL +
Sbjct: 151 ILSIAYSPDGKYLASGAIDGIINIFDI--ATGKLLH-TLEGHAMPIRSLTFSPDSQLLVT 207
Query: 209 GSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCL 268
S D I I+ ++L L GH +WV ++AF PD+ S+ + VKVWD T C+
Sbjct: 208 ASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCV 267
Query: 269 ETLKGVLDVAHTCAFTPDGKILVSGAADQ 297
T D + +G +VS DQ
Sbjct: 268 HTFFDHQDQVWGVKYNGNGSKIVSVGDDQ 296
Score = 95.9 bits (237), Expect = 4e-20
Identities = 54/176 (30%), Positives = 86/176 (48%), Gaps = 11/176 (6%)
Query: 11 VRRVKFFGQHGGE-----------VNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRL 59
V +V FG G+ + S A+SPDG+ L +G+ DG + ++ +G+LL L
Sbjct: 127 VGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTL 186
Query: 60 GGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQ 119
GH P++ FSPD L +AS D ++++DV A L GH V V+F PD
Sbjct: 187 EGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTH 246
Query: 120 LASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWD 175
S DK V +WDV + + H+D + ++ + + + D +HI+D
Sbjct: 247 FVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
Score = 90.1 bits (222), Expect = 2e-18
Identities = 58/192 (30%), Positives = 94/192 (48%), Gaps = 4/192 (2%)
Query: 28 AFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTV 87
AFSPD Q L TG+ G V + SG+ + L + +SPDG AS + D +
Sbjct: 113 AFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGII 172
Query: 88 RLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHR 147
++D+A K L L+GH + +++FSPDS+ L + D + ++DVQ + L GH
Sbjct: 173 NIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHA 232
Query: 148 DSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG-LL 206
+ + F P + S D +V +WD+ T H + H + + Y+ +G +
Sbjct: 233 SWVLNVAFCPDDTHFVSSSSDKSVKVWDVG--TRTCVHTFFD-HQDQVWGVKYNGNGSKI 289
Query: 207 ASGSWDKTIHIW 218
S D+ IHI+
Sbjct: 290 VSVGDDQEIHIY 301
Score = 87.4 bits (215), Expect = 1e-17
Identities = 66/222 (29%), Positives = 101/222 (45%), Gaps = 6/222 (2%)
Query: 80 SASCDCTVRLWDVA--RAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSG 137
+ S D V++W R L+GHQ V +V S AS D + LWD+++G
Sbjct: 37 TGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENG 96
Query: 138 QMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISC 197
+ ++ + + FSP LATG+ V+I+ V +L+ I
Sbjct: 97 KQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFG---VESGKKEYSLDTRGKFILS 153
Query: 198 LCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRM 256
+ YS G LASG+ D I+I+ T LL L+GH ++S+ FSPD L +A
Sbjct: 154 IAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGY 213
Query: 257 VKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQT 298
+K++D TL G AF PD VS ++D++
Sbjct: 214 IKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKS 255
>gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo
sapiens]
Length = 275
Score = 120 bits (300), Expect = 2e-27
Identities = 85/250 (34%), Positives = 123/250 (49%), Gaps = 35/250 (14%)
Query: 49 ETRSGQLLWRLGGHTGPVKFCRFSPDGHLF-ASASCDCTVRLWDVAR-AKCLRVLKGHQR 106
E G+LL L HT V+ F+PDG L SAS D T+R+WD+ ++VL+GHQ
Sbjct: 10 EKEIGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQN 69
Query: 107 SVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGS 166
V + +FSPDS L S G K V LW++ M+R L GH + + DFSP LAT S
Sbjct: 70 WVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATAS 129
Query: 167 WDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLL 226
+D+ V+IWD H+ +I L+ G H++ P T +
Sbjct: 130 YDTRVYIWD--------------PHNGDI---------LMEFG------HLFPPPTP--I 158
Query: 227 IQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPD 286
+ WV+S++FS D L +AS +MV+ W + ++ L CAF+ D
Sbjct: 159 FAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQV--APLSNGLCCAFSTD 216
Query: 287 GKILVSGAAD 296
G +L +G D
Sbjct: 217 GSVLAAGTHD 226
Score = 76.3 bits (186), Expect = 3e-14
Identities = 58/186 (31%), Positives = 78/186 (41%), Gaps = 17/186 (9%)
Query: 14 VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSP 73
+K H V S AFSPD ML + V+ W ++ +L GH V C FSP
Sbjct: 61 MKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSP 120
Query: 74 DGHLFASASCDCTVRLWDVARAKCLRVLKGH--------------QRSVETVSFSPDSRQ 119
DG L A+AS D V +WD L GH R V +VSFS D
Sbjct: 121 DGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLH 179
Query: 120 LASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMV 179
+AS DK V W + ++ V + FS + LA G+ D +V+ W
Sbjct: 180 VASLADDKMVRFWRIDEDYPVQ--VAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQ 237
Query: 180 TPAVSH 185
P++ H
Sbjct: 238 VPSLQH 243
Score = 68.6 bits (166), Expect = 7e-12
Identities = 50/169 (29%), Positives = 79/169 (46%), Gaps = 12/169 (7%)
Query: 137 GQMLRLLVGHRDSIQSSDFSPTVNC-LATGSWDSTVHIWDLRMVTPAVSHQALEGHSANI 195
G++L LV H + ++ F+P + L + S D T+ +WDL+ + L GH +
Sbjct: 14 GKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLK--DDGNMMKVLRGHQNWV 71
Query: 196 -SCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYS 254
SC S +L S K + +W +++ +L+GH V + FSPD LA+A Y
Sbjct: 72 YSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYD 131
Query: 255 RMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRRQIS 303
V +WD + G L ++ H F P I GA D+ R +S
Sbjct: 132 TRVYIWDPHNGDIL------MEFGH--LFPPPTPIFAGGANDRWVRSVS 172
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 119 bits (299), Expect = 3e-27
Identities = 86/296 (29%), Positives = 135/296 (45%), Gaps = 5/296 (1%)
Query: 6 PATLAVRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGP 65
PA + F H V+ + P +L++ ED +L GHT
Sbjct: 337 PAKFDYKLKNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDW 396
Query: 66 VKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGW 125
+ C F P G A++S D TV+LWD+ + C+ +GH R+V + ++ +AS
Sbjct: 397 LSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSL 456
Query: 126 DKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSH 185
DK +WDV S + L GH DS+ S +F P N L T S D T+ IWD R +
Sbjct: 457 DKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDAR---TGICE 513
Query: 186 QALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPD 244
Q+L GH +I+ + G ++AS +W ++ + + + F
Sbjct: 514 QSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSS 573
Query: 245 ELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
LA A + ++ + D +G+ + L G + AHT F+ DG+IL SG +D T R
Sbjct: 574 GRVLAQASGNGVIHLLDLKSGE-IHKLMGHENEAHTVVFSHDGEILFSGGSDGTVR 628
Score = 109 bits (272), Expect = 4e-24
Identities = 73/241 (30%), Positives = 107/241 (44%), Gaps = 3/241 (1%)
Query: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
H ++ F P G L T S D V W+ G + GH+ V C + G+ A
Sbjct: 393 HTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVA 452
Query: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
S+S D T ++WDV +C L GH SV ++ F P S L + DK + +WD ++G
Sbjct: 453 SSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGIC 512
Query: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLC 199
+ L GH SI + F P + +A+ +WD R + P VS G S
Sbjct: 513 EQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDI--GPSPGNEVNF 570
Query: 200 YSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKV 259
S+ +LA S + IH+ S + +L GH ++ FS D L S G V+
Sbjct: 571 DSSGRVLAQASGNGVIHL-LDLKSGEIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRT 629
Query: 260 W 260
W
Sbjct: 630 W 630
>gi|189571685 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
Length = 476
Score = 119 bits (299), Expect = 3e-27
Identities = 100/309 (32%), Positives = 138/309 (44%), Gaps = 27/309 (8%)
Query: 11 VRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWR--LGGHTGPVKF 68
V+ + HG +VN AFS +L T S D + + R L L HT V
Sbjct: 2 VKLIHTLADHGDDVNCCAFS--FSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHC 59
Query: 69 CRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRS-VETVSFSPDSRQLASGGWDK 127
C FSP GH+ AS S D T LW+ + L V++ S V FSPDS LASG D
Sbjct: 60 CCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADG 119
Query: 128 RVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQA 187
V+LW+ QS ++ R S+ + FSP + TGS + +WD +M H
Sbjct: 120 TVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM---RCLHSE 176
Query: 188 LEGHSANISCLCYSASGL-----------LASGSWDKTIHIWKPTTSSLL-------IQL 229
+ H I+C +S+ + LAS D + IW + + +L L
Sbjct: 177 -KAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTL 235
Query: 230 KGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKI 289
GH V + AFS D L S + V V+D NT L TL TCAF P+ +
Sbjct: 236 SGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLL 295
Query: 290 LVSGAADQT 298
L +G+ D+T
Sbjct: 296 LATGSMDKT 304
Score = 101 bits (251), Expect = 1e-21
Identities = 80/268 (29%), Positives = 118/268 (44%), Gaps = 21/268 (7%)
Query: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTG-PVKFCRFSPDGHLF 78
H V+ FSP G +L + S DG W T +GQ+L + +G PV+ C+FSPD
Sbjct: 53 HTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCL 112
Query: 79 ASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQ 138
AS + D TV LW+ K R S+ +FSP+ +G + +WD + +
Sbjct: 113 ASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM-R 171
Query: 139 MLRLLVGHRDSIQSSDFSPTVNC----------LATGSWDSTVHIWDLRMVT----PAVS 184
L H I DFS LA+ D V IW +
Sbjct: 172 CLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKY 231
Query: 185 HQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSP 243
L GH A + +S G +L SGS DK++ ++ T ++L L H +V + AF+P
Sbjct: 232 KSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAP 291
Query: 244 DELWLASAGYSRMVKVWDCNTGKCLETL 271
+ L LA+ + V +W + LETL
Sbjct: 292 NTLLLATGSMDKTVNIWQFD----LETL 315
>gi|189571683 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
Length = 476
Score = 119 bits (299), Expect = 3e-27
Identities = 100/309 (32%), Positives = 138/309 (44%), Gaps = 27/309 (8%)
Query: 11 VRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWR--LGGHTGPVKF 68
V+ + HG +VN AFS +L T S D + + R L L HT V
Sbjct: 2 VKLIHTLADHGDDVNCCAFS--FSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHC 59
Query: 69 CRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRS-VETVSFSPDSRQLASGGWDK 127
C FSP GH+ AS S D T LW+ + L V++ S V FSPDS LASG D
Sbjct: 60 CCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADG 119
Query: 128 RVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQA 187
V+LW+ QS ++ R S+ + FSP + TGS + +WD +M H
Sbjct: 120 TVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM---RCLHSE 176
Query: 188 LEGHSANISCLCYSASGL-----------LASGSWDKTIHIWKPTTSSLL-------IQL 229
+ H I+C +S+ + LAS D + IW + + +L L
Sbjct: 177 -KAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTL 235
Query: 230 KGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKI 289
GH V + AFS D L S + V V+D NT L TL TCAF P+ +
Sbjct: 236 SGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLL 295
Query: 290 LVSGAADQT 298
L +G+ D+T
Sbjct: 296 LATGSMDKT 304
Score = 101 bits (251), Expect = 1e-21
Identities = 80/268 (29%), Positives = 118/268 (44%), Gaps = 21/268 (7%)
Query: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTG-PVKFCRFSPDGHLF 78
H V+ FSP G +L + S DG W T +GQ+L + +G PV+ C+FSPD
Sbjct: 53 HTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCL 112
Query: 79 ASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQ 138
AS + D TV LW+ K R S+ +FSP+ +G + +WD + +
Sbjct: 113 ASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM-R 171
Query: 139 MLRLLVGHRDSIQSSDFSPTVNC----------LATGSWDSTVHIWDLRMVT----PAVS 184
L H I DFS LA+ D V IW +
Sbjct: 172 CLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKY 231
Query: 185 HQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSP 243
L GH A + +S G +L SGS DK++ ++ T ++L L H +V + AF+P
Sbjct: 232 KSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAP 291
Query: 244 DELWLASAGYSRMVKVWDCNTGKCLETL 271
+ L LA+ + V +W + LETL
Sbjct: 292 NTLLLATGSMDKTVNIWQFD----LETL 315
>gi|189571681 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
Length = 476
Score = 119 bits (299), Expect = 3e-27
Identities = 100/309 (32%), Positives = 138/309 (44%), Gaps = 27/309 (8%)
Query: 11 VRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWR--LGGHTGPVKF 68
V+ + HG +VN AFS +L T S D + + R L L HT V
Sbjct: 2 VKLIHTLADHGDDVNCCAFS--FSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHC 59
Query: 69 CRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRS-VETVSFSPDSRQLASGGWDK 127
C FSP GH+ AS S D T LW+ + L V++ S V FSPDS LASG D
Sbjct: 60 CCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADG 119
Query: 128 RVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQA 187
V+LW+ QS ++ R S+ + FSP + TGS + +WD +M H
Sbjct: 120 TVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM---RCLHSE 176
Query: 188 LEGHSANISCLCYSASGL-----------LASGSWDKTIHIWKPTTSSLL-------IQL 229
+ H I+C +S+ + LAS D + IW + + +L L
Sbjct: 177 -KAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTL 235
Query: 230 KGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKI 289
GH V + AFS D L S + V V+D NT L TL TCAF P+ +
Sbjct: 236 SGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLL 295
Query: 290 LVSGAADQT 298
L +G+ D+T
Sbjct: 296 LATGSMDKT 304
Score = 101 bits (251), Expect = 1e-21
Identities = 80/268 (29%), Positives = 118/268 (44%), Gaps = 21/268 (7%)
Query: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTG-PVKFCRFSPDGHLF 78
H V+ FSP G +L + S DG W T +GQ+L + +G PV+ C+FSPD
Sbjct: 53 HTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCL 112
Query: 79 ASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQ 138
AS + D TV LW+ K R S+ +FSP+ +G + +WD + +
Sbjct: 113 ASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM-R 171
Query: 139 MLRLLVGHRDSIQSSDFSPTVNC----------LATGSWDSTVHIWDLRMVT----PAVS 184
L H I DFS LA+ D V IW +
Sbjct: 172 CLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKY 231
Query: 185 HQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSP 243
L GH A + +S G +L SGS DK++ ++ T ++L L H +V + AF+P
Sbjct: 232 KSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAP 291
Query: 244 DELWLASAGYSRMVKVWDCNTGKCLETL 271
+ L LA+ + V +W + LETL
Sbjct: 292 NTLLLATGSMDKTVNIWQFD----LETL 315
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 119 bits (297), Expect = 5e-27
Identities = 88/303 (29%), Positives = 138/303 (45%), Gaps = 16/303 (5%)
Query: 20 HGGEVNSSAFSP-DGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLF 78
H V+S G++L TG +D V W + L GHT PV+ R + L
Sbjct: 19 HASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELI 78
Query: 79 ASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQ 138
+ S ++R+WD+ AK LR L GH+ ++ ++ F P +ASG D + LWD++
Sbjct: 79 VAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKG 138
Query: 139 MLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCL 198
+ GH +++ FSP LA+ + D TV +WDL T GH+ ++ +
Sbjct: 139 CVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDL---TAGKMMSEFPGHTGPVNVV 195
Query: 199 CYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMV 257
+ + LLASGS D+TI W ++ ++G V+S+ F+PD L S G +
Sbjct: 196 EFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYS-GCQDSL 254
Query: 258 KVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILV--------SGAADQTRRQISRTSKSP 309
+V+ +C + + A D I V S D TR ++RT
Sbjct: 255 RVYGWEPERCFDVVLVNWGKVADLAICNDQLIGVAFSQSNVSSYVVDLTR--VTRTGTVA 312
Query: 310 RDP 312
RDP
Sbjct: 313 RDP 315
Score = 46.2 bits (108), Expect = 4e-05
Identities = 26/85 (30%), Positives = 42/85 (49%), Gaps = 1/85 (1%)
Query: 17 FGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGH 76
F H G VN F P+ +L +GS D + W+ Q++ + G GPV+ F+PDG
Sbjct: 185 FPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGC 244
Query: 77 LFASASCDCTVRLWDVARAKCLRVL 101
S C ++R++ +C V+
Sbjct: 245 CLYS-GCQDSLRVYGWEPERCFDVV 268
>gi|8923881 WD SOCS-box protein 2 [Homo sapiens]
Length = 404
Score = 118 bits (295), Expect = 8e-27
Identities = 75/196 (38%), Positives = 107/196 (54%), Gaps = 12/196 (6%)
Query: 35 MLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLF-ASASCDCTVRLWDVA 93
+L TG DG + WE ++G LL L GH V+ F+P G L SAS D T+R+WD+
Sbjct: 125 VLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLN 184
Query: 94 R-AKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQS 152
+ K ++VL GH + V S SPD L S +K V LW ++S ++R L GH+ S+ S
Sbjct: 185 KHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVS 244
Query: 153 SDFSPTVNCLATGSWDSTVHIWD------LRMVTPAVSHQALEGHSANISCL---CYSAS 203
DFSP L T S+D+ V +WD LR + A++ +IS L C+S
Sbjct: 245 CDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPE 304
Query: 204 GL-LASGSWDKTIHIW 218
GL LA+ + D+ + IW
Sbjct: 305 GLYLATVADDRLLRIW 320
Score = 93.2 bits (230), Expect = 3e-19
Identities = 86/316 (27%), Positives = 136/316 (43%), Gaps = 62/316 (19%)
Query: 51 RSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRL--WDVARAKCLRVLKGHQRS- 107
R Q W+ T V F SPDG FA + C V+L W + + + RS
Sbjct: 17 RPHQFDWKSSCETWSVAF---SPDGSWFAWSQGHCIVKLIPWPLEEQFIPKGFEAKSRSS 73
Query: 108 --------------------VETVSF----SPDSRQ----------------LASGGWDK 127
V ++F SP SR+ LA+G D
Sbjct: 74 KNETKGRGSPKEKTLDCGQIVWGLAFSPWPSPPSRKLWARHHPQVPDVSCLVLATGLNDG 133
Query: 128 RVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVN-CLATGSWDSTVHIWDLRMVTPAVSHQ 186
++ +W+VQ+G +L L GH+D ++ F+P+ + L + S D T+ IWDL + Q
Sbjct: 134 QIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQI--Q 191
Query: 187 ALEGHSANISCLCYSAS-GLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDE 245
L GH + C S +L S + +K++ +W + +L+ +L+GH + V S FSPD
Sbjct: 192 VLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDS 251
Query: 246 LWLASAGYSRMVKVWDCNTGKCLETLKGV------------LDVAHTCAFTPDGKILVSG 293
L +A Y V +WD TG+ L +L + + F+P+G L +
Sbjct: 252 ALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEGLYLATV 311
Query: 294 AADQTRRQISRTSKSP 309
A D+ R + K+P
Sbjct: 312 ADDRLLRIWALELKTP 327
Score = 70.5 bits (171), Expect = 2e-12
Identities = 52/188 (27%), Positives = 81/188 (43%), Gaps = 18/188 (9%)
Query: 12 RRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRF 71
++++ H V + SPD ML + + + V+ W RS L+ +L GH V C F
Sbjct: 188 KQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDF 247
Query: 72 SPDGHLFASASCDCTVRLWDVARAKCLRVLKG------------HQRSVETVSFSPDSRQ 119
SPD L +AS D V +WD + LR L H S+ +V FSP+
Sbjct: 248 SPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEGLY 307
Query: 120 LASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQS--SDFSPTVNCLATGSWDSTVHIWDLR 177
LA+ D+ + +W ++ L+ + F P +ATG+ D V W
Sbjct: 308 LATVADDRLLRIWALE----LKTPIAFAPMTNGLCCTFFPHGGVIATGTRDGHVQFWTAP 363
Query: 178 MVTPAVSH 185
V ++ H
Sbjct: 364 RVLSSLKH 371
>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
[Homo sapiens]
Length = 340
Score = 115 bits (288), Expect = 5e-26
Identities = 72/243 (29%), Positives = 115/243 (47%), Gaps = 7/243 (2%)
Query: 24 VNSSAFSPDGQMLLTGSEDGC--VYGWETRSG--QLLWRLGGHTGPVKFCRFSPDGHLFA 79
V + A++P G + G D +Y +TR G ++ L GHTG + CRF D +
Sbjct: 100 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVT 159
Query: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
S+ D T LWD+ + GH V ++S +PD+R SG D LWDV+ G
Sbjct: 160 SSG-DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMC 218
Query: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLC 199
+ GH I + F P N ATGS D+T ++DLR +++ + I+ +
Sbjct: 219 RQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSH-DNIICGITSVS 277
Query: 200 YSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVK 258
+S SG LL +G D ++W + L GH V + + D + +A+ + +K
Sbjct: 278 FSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLK 337
Query: 259 VWD 261
+W+
Sbjct: 338 IWN 340
Score = 107 bits (268), Expect = 1e-23
Identities = 64/212 (30%), Positives = 98/212 (46%), Gaps = 9/212 (4%)
Query: 11 VRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCR 70
VR + H G ++ F D Q++ + + C W+ +GQ GHTG V
Sbjct: 133 VRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCAL-WDIETGQQTTTFTGHTGDVMSLS 191
Query: 71 FSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVM 130
+PD LF S +CD + +LWDV C + GH+ + + F P+ A+G D
Sbjct: 192 LAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCR 251
Query: 131 LWDVQSGQMLRLLVGHRD---SIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQA 187
L+D+++ Q L + H + I S FS + L G D ++WD A
Sbjct: 252 LFDLRADQEL-MTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRA---GV 307
Query: 188 LEGHSANISCLCYSASGL-LASGSWDKTIHIW 218
L GH +SCL + G+ +A+GSWD + IW
Sbjct: 308 LAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339
Score = 87.8 bits (216), Expect = 1e-17
Identities = 51/203 (25%), Positives = 88/203 (43%), Gaps = 1/203 (0%)
Query: 99 RVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPT 158
R L+GH + + + DSR L S D ++++WD + + + + + ++P+
Sbjct: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
Query: 159 VNCLATGSWDSTVHIWDLRMVTPAVS-HQALEGHSANISCLCYSASGLLASGSWDKTIHI 217
N +A G D+ I++L+ V + L GH+ +SC + + + S D T +
Sbjct: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCAL 168
Query: 218 WKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDV 277
W T GH V S++ +PD S K+WD G C +T G
Sbjct: 169 WDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESD 228
Query: 278 AHTCAFTPDGKILVSGAADQTRR 300
+ F P+G +G+ D T R
Sbjct: 229 INAICFFPNGNAFATGSDDATCR 251
Score = 83.2 bits (204), Expect = 3e-16
Identities = 50/162 (30%), Positives = 77/162 (47%), Gaps = 4/162 (2%)
Query: 17 FGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGH 76
F H G+V S + +PD ++ ++G+ D W+ R G GH + F P+G+
Sbjct: 180 FTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGN 239
Query: 77 LFASASCDCTVRLWDVARAKCLRVLKGHQR---SVETVSFSPDSRQLASGGWDKRVMLWD 133
FA+ S D T RL+D+ RA + H + +VSFS R L +G D +WD
Sbjct: 240 AFATGSDDATCRLFDL-RADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWD 298
Query: 134 VQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWD 175
+L GH + + + +ATGSWDS + IW+
Sbjct: 299 ALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Score = 68.2 bits (165), Expect = 9e-12
Identities = 61/287 (21%), Positives = 101/287 (35%), Gaps = 53/287 (18%)
Query: 59 LGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSR 118
L GH + + D L SAS D + +WD + + V T +++P
Sbjct: 51 LRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGN 110
Query: 119 QLASGGWDK---------------------------------------------RVMLWD 133
+A GG D LWD
Sbjct: 111 YVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWD 170
Query: 134 VQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSA 193
+++GQ GH + S +P +G+ D++ +WD+R + Q GH +
Sbjct: 171 IETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVR---EGMCRQTFTGHES 227
Query: 194 NISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLK--GHVTWVKSIAFSPDELWLAS 250
+I+ +C+ +G A+GS D T ++ L+ + + S++FS L
Sbjct: 228 DINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGR-LLL 286
Query: 251 AGYSRM-VKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAAD 296
AGY VWD L G + T DG + +G+ D
Sbjct: 287 AGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWD 333
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 113 bits (282), Expect = 2e-25
Identities = 67/241 (27%), Positives = 121/241 (50%), Gaps = 12/241 (4%)
Query: 33 GQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDV 92
G +++GS+D + W +G+ L L GHTG V + + + S S D T+++W+
Sbjct: 273 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNA 330
Query: 93 ARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQS 152
+C+ L GH +V + +++ SG D + +WD+++GQ L +L+GH +++
Sbjct: 331 ETGECIHTLYGHTSTVRCMHLH--EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRC 388
Query: 153 SDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWD 212
+ + +G++D V +WD T L+GH+ + L + ++ SGS D
Sbjct: 389 VQYDG--RRVVSGAYDFMVKVWDPETETCL---HTLQGHTNRVYSLQFDGIHVV-SGSLD 442
Query: 213 KTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLK 272
+I +W T + + L GH + + + L S VK+WD TG+CL+TL+
Sbjct: 443 TSIRVWDVETGNCIHTLTGHQSLTSGMELKDNIL--VSGNADSTVKIWDIKTGQCLQTLQ 500
Query: 273 G 273
G
Sbjct: 501 G 501
Score = 107 bits (266), Expect = 2e-23
Identities = 77/255 (30%), Positives = 127/255 (49%), Gaps = 17/255 (6%)
Query: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
H G V SS + ++++GS D + W +G+ + L GHT V+ C + +
Sbjct: 302 HTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVR-CMHLHEKRV-V 357
Query: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
S S D T+R+WD+ +CL VL GH +V V + D R++ SG +D V +WD ++
Sbjct: 358 SGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETC 415
Query: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLC 199
L L GH + + S F + +GS D+++ +WD+ T H L GH + S +
Sbjct: 416 LHTLQGHTNRVYSLQFDGI--HVVSGSLDTSIRVWDVE--TGNCIH-TLTGHQSLTSGM- 469
Query: 200 YSASGLLASGSWDKTIHIWKPTTSSLLIQLKG---HVTWVKSIAFSPDELWLASAGYSRM 256
+L SG+ D T+ IW T L L+G H + V + F+ + ++ ++
Sbjct: 470 ELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGT 527
Query: 257 VKVWDCNTGKCLETL 271
VK+WD TG+ + L
Sbjct: 528 VKLWDLKTGEFIRNL 542
Score = 99.0 bits (245), Expect = 5e-21
Identities = 71/211 (33%), Positives = 103/211 (48%), Gaps = 11/211 (5%)
Query: 90 WDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDS 149
W K +VLKGH V T +R + SG D + +W +G+ LR LVGH
Sbjct: 247 WRRGELKSPKVLKGHDDHVITCLQFCGNR-IVSGSDDNTLKVWSAVTGKCLRTLVGHTGG 305
Query: 150 IQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASG 209
+ SS N + +GS D T+ +W+ T H L GH++ + C+ + + SG
Sbjct: 306 VWSSQMRD--NIIISGSTDRTLKVWNAE--TGECIH-TLYGHTSTVRCM-HLHEKRVVSG 359
Query: 210 SWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLE 269
S D T+ +W T L L GHV V+ + + D + S Y MVKVWD T CL
Sbjct: 360 SRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLH 417
Query: 270 TLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
TL+G + ++ F DG +VSG+ D + R
Sbjct: 418 TLQGHTNRVYSLQF--DGIHVVSGSLDTSIR 446
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 113 bits (282), Expect = 2e-25
Identities = 67/241 (27%), Positives = 121/241 (50%), Gaps = 12/241 (4%)
Query: 33 GQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDV 92
G +++GS+D + W +G+ L L GHTG V + + + S S D T+++W+
Sbjct: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNA 448
Query: 93 ARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQS 152
+C+ L GH +V + +++ SG D + +WD+++GQ L +L+GH +++
Sbjct: 449 ETGECIHTLYGHTSTVRCMHLH--EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRC 506
Query: 153 SDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWD 212
+ + +G++D V +WD T L+GH+ + L + ++ SGS D
Sbjct: 507 VQYDG--RRVVSGAYDFMVKVWDPETETCL---HTLQGHTNRVYSLQFDGIHVV-SGSLD 560
Query: 213 KTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLK 272
+I +W T + + L GH + + + L S VK+WD TG+CL+TL+
Sbjct: 561 TSIRVWDVETGNCIHTLTGHQSLTSGMELKDNIL--VSGNADSTVKIWDIKTGQCLQTLQ 618
Query: 273 G 273
G
Sbjct: 619 G 619
Score = 107 bits (266), Expect = 2e-23
Identities = 77/255 (30%), Positives = 127/255 (49%), Gaps = 17/255 (6%)
Query: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
H G V SS + ++++GS D + W +G+ + L GHT V+ C + +
Sbjct: 420 HTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVR-CMHLHEKRV-V 475
Query: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
S S D T+R+WD+ +CL VL GH +V V + D R++ SG +D V +WD ++
Sbjct: 476 SGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETC 533
Query: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLC 199
L L GH + + S F + +GS D+++ +WD+ T H L GH + S +
Sbjct: 534 LHTLQGHTNRVYSLQFDGI--HVVSGSLDTSIRVWDVE--TGNCIH-TLTGHQSLTSGM- 587
Query: 200 YSASGLLASGSWDKTIHIWKPTTSSLLIQLKG---HVTWVKSIAFSPDELWLASAGYSRM 256
+L SG+ D T+ IW T L L+G H + V + F+ + ++ ++
Sbjct: 588 ELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGT 645
Query: 257 VKVWDCNTGKCLETL 271
VK+WD TG+ + L
Sbjct: 646 VKLWDLKTGEFIRNL 660
Score = 99.0 bits (245), Expect = 5e-21
Identities = 71/211 (33%), Positives = 103/211 (48%), Gaps = 11/211 (5%)
Query: 90 WDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDS 149
W K +VLKGH V T +R + SG D + +W +G+ LR LVGH
Sbjct: 365 WRRGELKSPKVLKGHDDHVITCLQFCGNR-IVSGSDDNTLKVWSAVTGKCLRTLVGHTGG 423
Query: 150 IQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASG 209
+ SS N + +GS D T+ +W+ T H L GH++ + C+ + + SG
Sbjct: 424 VWSSQMRD--NIIISGSTDRTLKVWNAE--TGECIH-TLYGHTSTVRCM-HLHEKRVVSG 477
Query: 210 SWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLE 269
S D T+ +W T L L GHV V+ + + D + S Y MVKVWD T CL
Sbjct: 478 SRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLH 535
Query: 270 TLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
TL+G + ++ F DG +VSG+ D + R
Sbjct: 536 TLQGHTNRVYSLQF--DGIHVVSGSLDTSIR 564
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 113 bits (282), Expect = 2e-25
Identities = 67/241 (27%), Positives = 121/241 (50%), Gaps = 12/241 (4%)
Query: 33 GQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDV 92
G +++GS+D + W +G+ L L GHTG V + + + S S D T+++W+
Sbjct: 311 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNA 368
Query: 93 ARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQS 152
+C+ L GH +V + +++ SG D + +WD+++GQ L +L+GH +++
Sbjct: 369 ETGECIHTLYGHTSTVRCMHLH--EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRC 426
Query: 153 SDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWD 212
+ + +G++D V +WD T L+GH+ + L + ++ SGS D
Sbjct: 427 VQYDG--RRVVSGAYDFMVKVWDPETETCL---HTLQGHTNRVYSLQFDGIHVV-SGSLD 480
Query: 213 KTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLK 272
+I +W T + + L GH + + + L S VK+WD TG+CL+TL+
Sbjct: 481 TSIRVWDVETGNCIHTLTGHQSLTSGMELKDNIL--VSGNADSTVKIWDIKTGQCLQTLQ 538
Query: 273 G 273
G
Sbjct: 539 G 539
Score = 107 bits (266), Expect = 2e-23
Identities = 77/255 (30%), Positives = 127/255 (49%), Gaps = 17/255 (6%)
Query: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
H G V SS + ++++GS D + W +G+ + L GHT V+ C + +
Sbjct: 340 HTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVR-CMHLHEKRV-V 395
Query: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
S S D T+R+WD+ +CL VL GH +V V + D R++ SG +D V +WD ++
Sbjct: 396 SGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETC 453
Query: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLC 199
L L GH + + S F + +GS D+++ +WD+ T H L GH + S +
Sbjct: 454 LHTLQGHTNRVYSLQFDGI--HVVSGSLDTSIRVWDVE--TGNCIH-TLTGHQSLTSGM- 507
Query: 200 YSASGLLASGSWDKTIHIWKPTTSSLLIQLKG---HVTWVKSIAFSPDELWLASAGYSRM 256
+L SG+ D T+ IW T L L+G H + V + F+ + ++ ++
Sbjct: 508 ELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGT 565
Query: 257 VKVWDCNTGKCLETL 271
VK+WD TG+ + L
Sbjct: 566 VKLWDLKTGEFIRNL 580
Score = 99.0 bits (245), Expect = 5e-21
Identities = 71/211 (33%), Positives = 103/211 (48%), Gaps = 11/211 (5%)
Query: 90 WDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDS 149
W K +VLKGH V T +R + SG D + +W +G+ LR LVGH
Sbjct: 285 WRRGELKSPKVLKGHDDHVITCLQFCGNR-IVSGSDDNTLKVWSAVTGKCLRTLVGHTGG 343
Query: 150 IQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASG 209
+ SS N + +GS D T+ +W+ T H L GH++ + C+ + + SG
Sbjct: 344 VWSSQMRD--NIIISGSTDRTLKVWNAE--TGECIH-TLYGHTSTVRCM-HLHEKRVVSG 397
Query: 210 SWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLE 269
S D T+ +W T L L GHV V+ + + D + S Y MVKVWD T CL
Sbjct: 398 SRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLH 455
Query: 270 TLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
TL+G + ++ F DG +VSG+ D + R
Sbjct: 456 TLQGHTNRVYSLQF--DGIHVVSGSLDTSIR 484
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.132 0.430
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,859,434
Number of Sequences: 37866
Number of extensions: 551529
Number of successful extensions: 5437
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 279
Number of HSP's successfully gapped in prelim test: 74
Number of HSP's that attempted gapping in prelim test: 1171
Number of HSP's gapped (non-prelim): 1838
length of query: 314
length of database: 18,247,518
effective HSP length: 102
effective length of query: 212
effective length of database: 14,385,186
effective search space: 3049659432
effective search space used: 3049659432
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.