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Search of human proteins with 21237725
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21237725 phosphoinositide-3-kinase, catalytic, gamma
polypeptide [Homo sapiens]
(1102 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21237725 phosphoinositide-3-kinase, catalytic, gamma polypept... 2240 0.0
gi|54792082 phosphoinositide-3-kinase, catalytic, alpha polypept... 539 e-153
gi|5453894 catalytic phosphatidylinositol 3-kinase beta [Homo sa... 503 e-142
gi|156564405 catalytic phosphatidylinositol 3-kinase delta [Homo... 498 e-140
gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptid... 388 e-107
gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide... 372 e-103
gi|194353959 phosphoinositide-3-kinase, class 2 gamma polypeptid... 322 9e-88
gi|34761064 catalytic phosphatidylinositol 3-kinase 3 [Homo sapi... 189 1e-47
gi|4505807 phosphatidylinositol 4-kinase type 3 alpha isoform 1 ... 137 6e-32
gi|155030226 phosphatidylinositol 4-kinase type 3 alpha isoform ... 137 6e-32
gi|4505809 catalytic phosphatidylinositol 4-kinase beta [Homo sa... 124 6e-28
gi|239757646 PREDICTED: similar to phosphatidylinositol 4-kinase... 90 1e-17
gi|13654237 protein kinase, DNA-activated, catalytic polypeptide... 72 4e-12
gi|126032350 protein kinase, DNA-activated, catalytic polypeptid... 67 1e-10
gi|113430845 PREDICTED: similar to protein kinase, DNA-activated... 67 1e-10
gi|157266317 ataxia telangiectasia and Rad3 related protein [Hom... 54 6e-07
gi|169165926 PREDICTED: similar to ataxia telangiectasia and Rad... 54 6e-07
gi|20336199 ataxia telangiectasia mutated isoform 2 [Homo sapiens] 51 5e-06
gi|71902540 ataxia telangiectasia mutated isoform 1 [Homo sapiens] 51 5e-06
gi|169218268 PREDICTED: similar to Serine-protein kinase ATM, pa... 51 5e-06
gi|4826730 FK506 binding protein 12-rapamycin associated protein... 45 5e-04
gi|62243658 PI-3-kinase-related kinase SMG-1 [Homo sapiens] 45 5e-04
gi|33859670 leucine-rich repeats and calponin homology (CH) doma... 34 0.67
gi|62243696 stromal antigen 1 [Homo sapiens] 33 1.5
gi|56550039 myeloid/lymphoid or mixed-lineage leukemia protein [... 33 1.9
gi|239751459 PREDICTED: dynein, axonemal, heavy chain 17 [Homo s... 31 5.7
gi|239745966 PREDICTED: dynein, axonemal, heavy chain 17 [Homo s... 31 5.7
gi|32171205 EF-hand domain family, member A2 [Homo sapiens] 31 5.7
gi|190684679 hypothetical protein LOC126074 [Homo sapiens] 31 5.7
gi|239756957 PREDICTED: dynein, axonemal, heavy chain 17 [Homo s... 31 7.4
>gi|21237725 phosphoinositide-3-kinase, catalytic, gamma polypeptide
[Homo sapiens]
Length = 1102
Score = 2240 bits (5805), Expect = 0.0
Identities = 1102/1102 (100%), Positives = 1102/1102 (100%)
Query: 1 MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLH 60
MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLH
Sbjct: 1 MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLH 60
Query: 61 VAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLD 120
VAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLD
Sbjct: 61 VAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLD 120
Query: 121 CLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGL 180
CLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGL
Sbjct: 121 CLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGL 180
Query: 181 VTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDT 240
VTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDT
Sbjct: 181 VTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDT 240
Query: 241 PGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNG 300
PGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNG
Sbjct: 241 PGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNG 300
Query: 301 EEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRK 360
EEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRK
Sbjct: 301 EEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRK 360
Query: 361 FRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKI 420
FRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKI
Sbjct: 361 FRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKI 420
Query: 421 KDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEY 480
KDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEY
Sbjct: 421 KDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEY 480
Query: 481 VLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEG 540
VLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEG
Sbjct: 481 VLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEG 540
Query: 541 DRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQ 600
DRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQ
Sbjct: 541 DRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQ 600
Query: 601 QEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYL 660
QEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYL
Sbjct: 601 QEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYL 660
Query: 661 LQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAY 720
LQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAY
Sbjct: 661 LQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAY 720
Query: 721 LRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLP 780
LRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLP
Sbjct: 721 LRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLP 780
Query: 781 ESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQ 840
ESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQ
Sbjct: 781 ESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQ 840
Query: 841 DMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTG 900
DMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTG
Sbjct: 841 DMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTG 900
Query: 901 AFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNL 960
AFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNL
Sbjct: 901 AFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNL 960
Query: 961 FHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLAL 1020
FHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLAL
Sbjct: 961 FHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLAL 1020
Query: 1021 RHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGW 1080
RHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGW
Sbjct: 1021 RHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGW 1080
Query: 1081 TVQFNWFLHLVLGIKQGEKHSA 1102
TVQFNWFLHLVLGIKQGEKHSA
Sbjct: 1081 TVQFNWFLHLVLGIKQGEKHSA 1102
>gi|54792082 phosphoinositide-3-kinase, catalytic, alpha polypeptide
[Homo sapiens]
Length = 1068
Score = 539 bits (1388), Expect = e-153
Identities = 354/995 (35%), Positives = 532/995 (53%), Gaps = 86/995 (8%)
Query: 144 SEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPK------LYA 197
+ E + R++ IG V + V D E++ RR ++ V RD +Y
Sbjct: 107 NREEKILNREIGFAIGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYV 166
Query: 198 MHPWVTSKP-LPEYLWKKIANNCIFIVI------HRSTTSQTIKVSPDDTPGAILQSFFT 250
P V S P LP++++ K+ I +VI + T+K++ D P ++
Sbjct: 167 YPPNVESSPELPKHIYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIR 226
Query: 251 KMAKKKSL----MDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVV 306
K + L + + + + ++L+VCG DEY + + P+ ++++R C+ G +++
Sbjct: 227 KKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLM 286
Query: 307 LDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQL-TIHGKDHESVFTVSLWDCDRKFRVKI 365
L E + P+ DC + Y ++ T + T SLW + R+KI
Sbjct: 287 L------MAKESLYSQLPM--DCFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKI 338
Query: 366 R-GIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLP 424
+ V R+ D ++V I HG + LC + + WN WL + I I DLP
Sbjct: 339 LCATYVNVNIRDID-KIYVRTGIYHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLP 397
Query: 425 KGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHM 484
+ A L L I K K + E + G + L Y + L+ G+ L++
Sbjct: 398 RAARLCLSICSVKG----RKGAKEEHCPLAWGNINLFDYTDTLV--------SGKMALNL 445
Query: 485 WQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVR 544
W + ED N +T + NP+KE + + D + + P + V
Sbjct: 446 WPVPHGLEDL--LNPIGVTGS-NPNKETPC-LELEFDWFSSVVKFPDMSVIEEHANWSVS 501
Query: 545 AEM---------------PNQLRK----QLEAIIATDPLNPLTAEDKELLWHFRYESLKH 585
E N+LR+ QL+AI DPL+ +T ++K+ LW R+ +
Sbjct: 502 REAGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPLSEITEQEKDFLWSHRHYCVTI 561
Query: 586 PKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAV 645
P+ PKL SVKW ++ VA+ Y L V D + M+LLDCN+ D VR AV
Sbjct: 562 PEILPKLLLSVKWNSRDEVAQMYCL-----VKDWPPIKPEQAMELLDCNYPDPMVRGFAV 616
Query: 646 QKLES-LEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIA 704
+ LE L DD + YL+QLVQ +K+E Y D+ L RFLLK+ L N+RIGHF FW L+SE+
Sbjct: 617 RCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRIGHFFFWHLKSEM- 675
Query: 705 QSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVI 764
++ QRF ++LE+Y R CG + H +QV+ +E L +T DI L EK D + +V
Sbjct: 676 HNKTVSQRFGLLLESYCRACGMYLKH-LNRQVEAMEKLINLT-DI--LKQEKKDETQKV- 730
Query: 765 SQLKQKLENLQNSQLPES---FRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCAD-P 820
Q+K +E ++ ++ F P +P + G L +E+C++M+S K+PLWL ++ D
Sbjct: 731 -QMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIM 789
Query: 821 TALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIE 880
+ L + IIFK+GDDLRQDML LQI+RIME+IW+ + LDL +LPYGC+S GD +G+IE
Sbjct: 790 SELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIE 849
Query: 881 IVKDATTIAKIQQSTVGNTGA--FKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVA 938
+V+++ TI +IQ G GA F L+ WLK+K+ E + AA++ F SCAGYCVA
Sbjct: 850 VVRNSHTIMQIQCKG-GLKGALQFNSHTLHQWLKDKNKGEI-YDAAIDLFTRSCAGYCVA 907
Query: 939 TFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTS 998
TF+LGIGDRHN NIM+ + G LFHIDFGH L + K G +ERVPFVLT DFL V+
Sbjct: 908 TFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKG 967
Query: 999 GKKTSP--HFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALT 1056
++ + F++FQ++C KAYLA+R H NL I LFSMML +GMP+L S +DI YIR L
Sbjct: 968 AQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLA 1027
Query: 1057 VGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLV 1091
+ K E++A +YF+ Q+ GWT + +W H +
Sbjct: 1028 LDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTI 1062
>gi|5453894 catalytic phosphatidylinositol 3-kinase beta [Homo
sapiens]
Length = 1070
Score = 503 bits (1296), Expect = e-142
Identities = 329/911 (36%), Positives = 503/911 (55%), Gaps = 56/911 (6%)
Query: 207 LPEYLWKKIANNCIFIVIHRSTTSQ--TIKVSPDDTPGAILQSFFTKMAKKKSLMDIPES 264
+PE L K+ + + +H + +VSP+ P + + + K+ ++ +
Sbjct: 184 IPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKVNE---LAIQKRLTIHGKEDE 240
Query: 265 QSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWP 324
S D+VL+V GR EY+ G+ P+ FQ++R+C+ N H +L + ++ ++E
Sbjct: 241 VSPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRALPHFIL--VECCKIKKMYEQEMI 298
Query: 325 LVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFR-VKIRGIDIPVLPRNTDLTV-- 381
++ + L + K + V W+ + F+ V ++G + NT+ TV
Sbjct: 299 AIEAAINRNSSNLPLPLPPKKTRIISHV--WENNNPFQIVLVKGNKL-----NTEETVKV 351
Query: 382 FVEANIQHGQQVLCQRRTSPKPFTE-EVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPA 440
V A + HG ++LC+ S + + + +WN LEF I I DLP+ A L +Y
Sbjct: 352 HVRAGLFHGTELLCKTIVSSEVSGKNDHIWNEPLEFDINICDLPRMARLCFAVYAVLDKV 411
Query: 441 LSSKASAE-SPSS----ESKGKVQL-LYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQ 494
+ K++ +PS GKV + +VN ++ D + LR G+ +LH W S E +
Sbjct: 412 KTKKSTKTINPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRTGDIILHSWS-SFPDELE 470
Query: 495 GSFNADKLTSATNPDKENSMSISILL-DNYCHPIALPKHQPTPDPEGDRVRAEMPN---- 549
N T TNP EN+ ++ + +N P P + + ++ N
Sbjct: 471 EMLNPMG-TVQTNPYTENATALHVKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSR 529
Query: 550 ---QLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLK-HPKAYPKLFSSVKWGQQEIVA 605
+ L+ I+ DPL+ L + +L+W R + + P++ PKL S+KW + E VA
Sbjct: 530 GGKKFLPVLKEILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVA 589
Query: 606 KTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQ 665
QL A ++W + L ++LLD N+ D+ VR AV L + D+++ YLLQLVQ
Sbjct: 590 ---QLQALLQIWPK--LPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQ 644
Query: 666 AVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCG 725
+K+EP+ D AL+RFLL+R L N+RIG FLFW LRSE+ +F VILEAY RG
Sbjct: 645 VLKYEPFLDCALSRFLLERALGNRRIGQFLFWHLRSEV-HIPAVSVQFGVILEAYCRG-S 702
Query: 726 TAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSS---QVISQLKQKLENLQNSQLPES 782
+ ++QV+ + L+ + IK L+A K + + + + LKQ S L
Sbjct: 703 VGHMKVLSKQVEALNKLKTLNSLIK-LNAVKLNRAKGKEAMHTCLKQSAYREALSDLQS- 760
Query: 783 FRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDM 842
P +P + L +EKCK M SK KPLWL + + +++G+IFK+GDDLRQDM
Sbjct: 761 ---PLNPCVILSELYVEKCKYMDSKMKPLWLVY---NNKVFGEDSVGVIFKNGDDLRQDM 814
Query: 843 LILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQ--QSTVGNTG 900
L LQ+LR+M+ +W+ LDL +LPYGC++TGD+ G+IE+V + TIA IQ S V
Sbjct: 815 LTLQMLRLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNVAAAA 874
Query: 901 AFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNL 960
AF + L +WLKE + ++ A+E F SCAGYCVA++VLGIGDRH+DNIM+ +TG L
Sbjct: 875 AFNKDALLNWLKEYNSGDD-LDRAIEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQL 933
Query: 961 FHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLAL 1020
FHIDFGHILGN+KS GI +ERVPF+LT DF+ V+ + F +F+ C AYL L
Sbjct: 934 FHIDFGHILGNFKSKFGIKRERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLIL 993
Query: 1021 RHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGW 1080
R H NL I LF++ML G+P+LTS +DI+Y++D+L +GK+EE+A K F + + + W
Sbjct: 994 RRHGNLFITLFALMLTAGLPELTSVKDIQYLKDSLALGKSEEEALKQFKQKFDEALRESW 1053
Query: 1081 TVQFNWFLHLV 1091
T + NW H V
Sbjct: 1054 TTKVNWMAHTV 1064
>gi|156564405 catalytic phosphatidylinositol 3-kinase delta [Homo
sapiens]
Length = 1044
Score = 498 bits (1283), Expect = e-140
Identities = 310/883 (35%), Positives = 476/883 (53%), Gaps = 61/883 (6%)
Query: 227 STTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETP 286
S S T +VS D P A++ + KK ++ P + +D+ L+V GR EYL G P
Sbjct: 199 SEESFTFQVSTKDVPLALMAC---ALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYP 255
Query: 287 IKNFQWVRHCLKNGEEIHVVL------------DTPPDPALDEVRKEEWPLVDDCTGVTG 334
+ FQ++ CL +G H+ + + P P + + R + P+
Sbjct: 256 LCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPI--------- 306
Query: 335 YHEQLTIHGKDHESVFTVSLWDCDRKFRVK-IRGIDIPVLPRNTDLTVFVEANIQHGQQV 393
+ +VSLW ++ FR++ I+G + R + + V+A + HG ++
Sbjct: 307 ----------PAKKPSSVSLWSLEQPFRIELIQGSKVNADER---MKLVVQAGLFHGNEM 353
Query: 394 LCQRRTSPK-PFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSS 452
LC+ +S + E +W LEF I I DLP+ A L +Y + A S
Sbjct: 354 LCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYA----VIEKAKKARSTKK 409
Query: 453 ESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKEN 512
+SK + + NL+L D++ L+ GE L+MW +++G T +NP+ ++
Sbjct: 410 KSKKADCPIAWANLMLFDYKDQLKTGERCLYMW--PSVPDEKGELLNPTGTVRSNPNTDS 467
Query: 513 SMSISILLDNYC-HPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAED 571
+ ++ I L HP+ P + + + + + QL I+ L +
Sbjct: 468 AAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHE 527
Query: 572 KELLWHFRYESLKH-PKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQL 630
K+L+W R+E +H P+A +L KW + E VA+ LL W + L V ++L
Sbjct: 528 KDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCS---WPE--LPVLSALEL 582
Query: 631 LDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKR 690
LD +F D +V + A++ L L DD++ YLLQLVQ +K+E Y D L +FLL R L N++
Sbjct: 583 LDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRK 642
Query: 691 IGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIK 750
IGHFLFW LRSE+ RF +ILEAY RG T + +Q + + L+ + +K
Sbjct: 643 IGHFLFWHLRSEM-HVPSVALRFGLILEAYCRG-STHHMKVLMKQGEALSKLKALNDFVK 700
Query: 751 SLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKP 810
S + ++ + L + E + + P DP + +E+C M SK KP
Sbjct: 701 LSSQKTPKPQTKELMHLCMRQEAYLEAL--SHLQSPLDPSTLLAEVCVEQCTFMDSKMKP 758
Query: 811 LWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCI 870
LW+ + ++ A S ++GIIFK+GDDLRQDML LQ++++M+ +W+ E LDL + PYGC+
Sbjct: 759 LWIMY--SNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCL 816
Query: 871 STGDKIGMIEIVKDATTIAKIQ--QSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERF 928
TGD+ G+IE+V + TIA IQ +S + T AF + L +WLK K+P E A+E F
Sbjct: 817 PTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNP-GEALDRAIEEF 875
Query: 929 VYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLT 988
SCAGYCVAT+VLGIGDRH+DNIMI E+G LFHIDFGH LGN+K+ GIN+ERVPF+LT
Sbjct: 876 TLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILT 935
Query: 989 PDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDI 1048
DF+ V+ S F++F+ C +AY LR H L + LF++M G+P+L+ +DI
Sbjct: 936 YDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDI 995
Query: 1049 EYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLV 1091
+Y++D+L +GK EE+A K+F + + W + NW H V
Sbjct: 996 QYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNV 1038
>gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptide
[Homo sapiens]
Length = 1686
Score = 388 bits (997), Expect = e-107
Identities = 247/693 (35%), Positives = 386/693 (55%), Gaps = 39/693 (5%)
Query: 402 KPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGK-VQL 460
K F + W+ + F I+I LP ++L+L ++ + +++S SP S + K +
Sbjct: 733 KNFFYLIKWDELIIFPIQISQLPLESVLHLTLF-----GILNQSSGSSPDSNKQRKGPEA 787
Query: 461 LYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILL 520
L V+L L D + L G +L++W S G T K M +L
Sbjct: 788 LGKVSLPLFDFKRFLTCGTKLLYLWTSSHTNSVPG----------TVTKKGYVMERIVLQ 837
Query: 521 DNYCHPIALPKHQPTPDPEGDRVRAE----MPNQLRKQLEAIIATDPLNPLTAEDKELLW 576
++ P A TP + ++ + N ++ +L I+ D L+ EDK LW
Sbjct: 838 VDFPSP-AFDIIYTTPQVDRSIIQQHNLETLENDIKGKLLDILHKDSSLGLSKEDKAFLW 896
Query: 577 HFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFS 636
RY KHP PK+ +S + +AKTY LL + W AL + ++LLD F+
Sbjct: 897 EKRYYCFKHPNCLPKILASAPNWKWVNLAKTYSLLHQ---WP--ALYPLIALELLDSKFA 951
Query: 637 DENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLF 696
D+ VR++AV +E++ DD++ L Q VQA+K+E Y +S+L +FLL R L N +I H L+
Sbjct: 952 DQEVRSLAVTWIEAISDDELTDLLPQFVQALKYEIYLNSSLVQFLLSRALGNIQIAHNLY 1011
Query: 697 WFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEK 756
W L+ + + + R+ +L A L G + + +Q +++++L V ++ S
Sbjct: 1012 WLLKDALHDVQ-FSTRYEHVLGALLSVGGKRLREELLKQTKLVQLLGGVAEKVRQASGS- 1069
Query: 757 YDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFK 816
+ QV+ L++ +E +Q+ R+P P L A L I+ C +S PL +
Sbjct: 1070 ---ARQVV--LQRSMERVQSFFQKNKCRLPLKPSLVAKELNIKSCSFFSSNAVPLKVTMV 1124
Query: 817 CADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKI 876
ADP E I ++FK G+DLRQDML LQ+++IM+ IW E LDL ++ + C+STG
Sbjct: 1125 NADPMG---EEINVMFKVGEDLRQDMLALQMIKIMDKIWLKEGLDLRMVIFKCLSTGRDR 1181
Query: 877 GMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYC 936
GM+E+V + T+ KIQ G TG+FKD+ L WL++ +P+EE+++ A E F+YSCAG C
Sbjct: 1182 GMVELVPASDTLRKIQVE-YGVTGSFKDKPLAEWLRKYNPSEEEYEKASENFIYSCAGCC 1240
Query: 937 VATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMG 996
VAT+VLGI DRHNDNIM+ TG++FHIDFG LG+ + F ++R PFVLT D +V+
Sbjct: 1241 VATYVLGICDRHNDNIMLRSTGHMFHIDFGKFLGHAQMFGSFKRDRAPFVLTSDMAYVI- 1299
Query: 997 TSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALT 1056
G+K + FQ F D+C +AY +R TNL + L S+M+ +G+P+LTS +D++Y+RDAL
Sbjct: 1300 NGGEKPTIRFQLFVDLCCQAYNLIRKQTNLFLNLLSLMIPSGLPELTSIQDLKYVRDALQ 1359
Query: 1057 VGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLH 1089
+ +A +F IE T +FN+F+H
Sbjct: 1360 PQTTDAEATIFFTRLIESSLGSIAT-KFNFFIH 1391
>gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide
[Homo sapiens]
Length = 1634
Score = 372 bits (956), Expect = e-103
Identities = 246/738 (33%), Positives = 381/738 (51%), Gaps = 48/738 (6%)
Query: 370 IPVLPRNTDLTVFVEANIQHGQQVLC-----QRRTSPKPFTEEVLWNVWLEFSIKIKDLP 424
IP++ + ++ ++ HG + LC +R K ++W+ + F +++ LP
Sbjct: 641 IPIIWATSYEDFYLSCSLSHGGKELCSPLQTRRAHFSKYLFHLIVWDQQICFPVQVNRLP 700
Query: 425 KGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHM 484
+ LL +Y P S + A ++ + + L +V L + R +L G +L +
Sbjct: 701 RETLLCATLYALPIPPPGSSSEA----NKQRRVPEALGWVTTPLFNFRQVLTCGRKLLGL 756
Query: 485 WQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVR 544
W + + N SA N + +S+ + I I P GD+
Sbjct: 757 WPATQE-------NPSARWSAPNFHQPDSVILQIDFPTSAFDIKFTS------PPGDKFS 803
Query: 545 -----AEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWG 599
+ + +++L+ I+ + L LT DK+ LW RY + P + +S
Sbjct: 804 PRYEFGSLREEDQRKLKDIMQKESLYWLTDADKKRLWEKRYYCHSEVSSLPLVLASAPSW 863
Query: 600 QQEIVAKTYQLLAR-REVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLH 658
+ + Y LL + + Q AL LL F D+ VR +AVQ + SL D ++L
Sbjct: 864 EWACLPDIYVLLKQWTHMNHQDALG------LLHATFPDQEVRRMAVQWIGSLSDAELLD 917
Query: 659 YLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILE 718
YL QLVQA+K+E Y DS L RFLLKR + + R+ H+ FW L+ + S+ + R+ +L
Sbjct: 918 YLPQLVQALKYECYLDSPLVRFLLKRAVSDLRVTHYFFWLLKDGLKDSQ-FSIRYQYLLA 976
Query: 719 AYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLS-AEKYDVSSQVISQLKQKLENLQNS 777
A L CG + +F +Q ++ L K+ ++ + + + + + ++KQ
Sbjct: 977 ALLCCCGKGLREEFNRQCWLVNALAKLAQQVREAAPSARQGILRTGLEEVKQFFA----- 1031
Query: 778 QLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDD 837
L S R+P P L + C S PL L F+ DP E I +IFK GDD
Sbjct: 1032 -LNGSCRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLG---ENIRVIFKCGDD 1087
Query: 838 LRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVG 897
LRQDML LQ++RIM IW E LD+ ++ + C STG GM+E++ +A T+ KIQ G
Sbjct: 1088 LRQDMLTLQMIRIMSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAETLRKIQVEH-G 1146
Query: 898 NTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITET 957
TG+FKD L WL++ +P E++++ AVE F+YSCAG CVAT+VLGI DRHNDNIM+ T
Sbjct: 1147 VTGSFKDRPLADWLQKHNPGEDEYEKAVENFIYSCAGCCVATYVLGICDRHNDNIMLKTT 1206
Query: 958 GNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAY 1017
G++FHIDFG LG+ + F I ++R PFV T D +V+ G K S F F D+C +AY
Sbjct: 1207 GHMFHIDFGRFLGHAQMFGNIKRDRAPFVFTSDMAYVI-NGGDKPSSRFHDFVDLCCQAY 1265
Query: 1018 LALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRD 1077
+R HT+L + L +ML G+P+L+ ED++Y+ DAL E +A YF IE
Sbjct: 1266 NLIRKHTHLFLNLLGLMLSCGIPELSDLEDLKYVYDALRPQDTEANATTYFTRLIESSLG 1325
Query: 1078 KGWTVQFNWFLHLVLGIK 1095
T + N+F+H + +K
Sbjct: 1326 SVAT-KLNFFIHNLAQMK 1342
Score = 34.3 bits (77), Expect = 0.67
Identities = 38/187 (20%), Positives = 77/187 (41%), Gaps = 19/187 (10%)
Query: 123 RYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVT 182
RY + +PG+ + P R T G+++ +VS D+E+ L
Sbjct: 292 RYGNRKNATPGKNRRISAAPVGS------RPHTVANGHELFEVSEERDEEVAAFCHMLDI 345
Query: 183 PRMAEVASRDPKLYAM--HPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDT 240
R + D + Y + + W P PE+L ++ N + ++ R + T + T
Sbjct: 346 LR----SGSDIQDYFLTGYVWSAVTPSPEHLGDEV-NLKVTVLCDRLQEALTFTCNCSST 400
Query: 241 PGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNG 300
++ +D+ DFVL+ CG +E+L + + + +++++C K
Sbjct: 401 VDLLIYQTLCYTHDDLRNVDVG------DFVLKPCGLEEFLQNKHALGSHEYIQYCRKFD 454
Query: 301 EEIHVVL 307
+I + L
Sbjct: 455 IDIRLQL 461
>gi|194353959 phosphoinositide-3-kinase, class 2 gamma polypeptide
[Homo sapiens]
Length = 1445
Score = 322 bits (826), Expect = 9e-88
Identities = 186/541 (34%), Positives = 315/541 (58%), Gaps = 21/541 (3%)
Query: 536 PDPEGDRVRAEMP-NQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFS 594
PD E +R E P + K + + L+ E K LW +R+ + P +
Sbjct: 637 PDSEENRSNLEEPLKECIKHIARLSQKQTPLLLSEEKKRYLWFYRFYCNNENCSLPLVLG 696
Query: 595 SVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDD 654
S + V++ + +L RR + Q +GL L +F D+ +R +AVQ+L++L +D
Sbjct: 697 SAPGWDERTVSEMHTIL-RRWTFSQPLEALGL----LTSSFPDQEIRKVAVQQLDNLLND 751
Query: 655 DVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFA 714
++L YL QLVQAVKFE +S L + LL R L++ ++ H L+W L++ A++ Y + +
Sbjct: 752 ELLEYLPQLVQAVKFEWNLESPLVQLLLHRSLQSIQVAHRLYWLLKN--AENEAYFKSWY 809
Query: 715 VILEAYLRGC-GTAMLHDFTQQVQVIEMLQKVTLDIKSLSA-EKYDVSSQVISQLKQKLE 772
L A L+ C G A+ +F+++ ++I++L + +KS S ++ +V + I +L++ +
Sbjct: 810 QKLLAALQFCAGKALNDEFSKEQKLIKILGDIGERVKSASDHQRQEVLKKEIGRLEEFFQ 869
Query: 773 NLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIF 832
++ LP +P L + + C S PL + F A+P + I IIF
Sbjct: 870 DVNTCHLP------LNPALCIKGIDHDACSYFTSNALPLKITFINANPMG---KNISIIF 920
Query: 833 KHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQ 892
K GDDLRQDML+LQ++++M++IW E LD+ ++ Y C+STG G++++V DA T+AKI
Sbjct: 921 KAGDDLRQDMLVLQLIQVMDNIWLQEGLDMQMIIYRCLSTGKDQGLVQMVPDAVTLAKIH 980
Query: 893 QSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNI 952
+ + G G K+ + W + + + ++ A+ F YSCAG+CV TF+LG+ DRHNDNI
Sbjct: 981 RHS-GLIGPLKENTIKKWFSQHNHLKADYEKALRNFFYSCAGWCVVTFILGVCDRHNDNI 1039
Query: 953 MITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDI 1012
M+T++G++FHIDFG LG+ ++F GI ++R PF+ T + + + T G K HFQ F ++
Sbjct: 1040 MLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFI-TEGGKNPQHFQDFVEL 1098
Query: 1013 CVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQI 1072
C +AY +R H+ LL+ L MML G+P+L+ +D++Y+ + L + +A +F +I
Sbjct: 1099 CCRAYNIIRKHSQLLLNLLEMMLYAGLPELSGIQDLKYVYNNLRPQDTDLEATSHFTKKI 1158
Query: 1073 E 1073
+
Sbjct: 1159 K 1159
>gi|34761064 catalytic phosphatidylinositol 3-kinase 3 [Homo sapiens]
Length = 887
Score = 189 bits (480), Expect = 1e-47
Identities = 162/594 (27%), Positives = 262/594 (44%), Gaps = 94/594 (15%)
Query: 552 RKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLL 611
R QL I++ P LT E+++L+W FRY KA K V W + + +LL
Sbjct: 293 RDQLNIIVSYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLPQEAKQALELL 352
Query: 612 ARREVWD-------------------------QSALDVGLTMQLLDC-------NFSD-- 637
+ + D + A D L M LL NF D
Sbjct: 353 GKWKPMDVEDSLELLSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDDIK 412
Query: 638 ---------------ENVRAIAVQKLESLEDDDVLHYLLQLVQ----AVKFEPYHDSA-- 676
ENV + E ++ ++ L V A K + D
Sbjct: 413 NGLEPTKKDSQSSVSENVSNSGINSAE-IDSSQIITSPLPSVSSPPPASKTKEVPDGENL 471
Query: 677 ---LARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYL---RGCGTAMLH 730
L FL+ R +N + ++L+W++ E + + QQR E YL R A+L
Sbjct: 472 EQDLCTFLISRACKNSTLANYLYWYVIVE-CEDQDTQQRDPKTHEMYLNVMRRFSQALLK 530
Query: 731 DFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQ---------NSQLPE 781
+ V+V+ L + K+K E LQ N E
Sbjct: 531 G-DKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVE 589
Query: 782 SFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQD 841
+P +P +K + E + S P L FK D +IFKHGDDLRQD
Sbjct: 590 LIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTED-----GGKYPVIFKHGDDLRQD 644
Query: 842 MLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGA 901
LILQI+ +M+ + E+LDL L PY ++T K G ++ ++ + +A++ + G+
Sbjct: 645 QLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQ-SVPVAEV----LDTEGS 699
Query: 902 FKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLF 961
++ + E P + ++ +V SCAGYCV T++LG+GDRH DN+++T+TG LF
Sbjct: 700 IQNFFRKYAPSENGPNGISAEV-MDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLF 758
Query: 962 HIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALR 1021
HIDFG+ILG + + +P + + V G G + S +Q+F+ C A+L LR
Sbjct: 759 HIDFGYILGR-------DPKPLPPPMKLNKEMVEGMGGTQ-SEQYQEFRKQCYTAFLHLR 810
Query: 1022 HHTNLLIILFSMMLMTGMPQLTSKED--IEYIRDALTVGKNEEDAKKYFLDQIE 1073
++NL++ LFS+M+ +P + + D ++ ++D + ++E+A Y I+
Sbjct: 811 RYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLID 864
Score = 35.8 bits (81), Expect = 0.23
Identities = 17/45 (37%), Positives = 25/45 (55%)
Query: 390 GQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIY 434
G+ + RTS K F+ WN WL+ +K DLP+ A + L I+
Sbjct: 67 GKPLALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIW 111
>gi|4505807 phosphatidylinositol 4-kinase type 3 alpha isoform 1 [Homo
sapiens]
Length = 854
Score = 137 bits (345), Expect = 6e-32
Identities = 123/457 (26%), Positives = 218/457 (47%), Gaps = 40/457 (8%)
Query: 645 VQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIA 704
V+ L S D +L Y+ Q+VQA++++ + ++L +++ + H W +++ I
Sbjct: 391 VKVLRSFPPDAILFYIPQIVQALRYDKM--GYVREYILWAASKSQLLAHQFIWNMKTNIY 448
Query: 705 QSRHYQQRFAVI------LEAYLRGCGTAMLHDFTQ-QVQVIEMLQKVTLDIKSLSA--E 755
Q+ I L + G + DF Q + + V+ IK E
Sbjct: 449 LDEEGHQKDPDIGDLLDQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDE 508
Query: 756 KYDVSSQVISQLKQKL-----ENLQNSQLPESFR--VPYDPGLKAGALA---IEKCKVMA 805
+ +S++K + N + L ++ P KA LA +++C V
Sbjct: 509 RKKACLSALSEVKVQPGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSE 568
Query: 806 SKKKPLWL----EFKCADPTALSNETI--GIIFKHGDDLRQDMLILQILRIMESIWETES 859
+K+ L E +C+ A + IFK GDD RQDML LQI+ + ++I++
Sbjct: 569 LEKEGLRCRSDSEDECSTQEADGQKISWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLVG 628
Query: 860 LDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEE 919
LDL + PY ++T G+IE + D T+ ++ + T + G + D + E +
Sbjct: 629 LDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQT--DFGMY-DYFTRQYGDESTLA-- 683
Query: 920 KFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGIN 979
FQ A F+ S A Y + F+L I DRHN NIM+ + G++ HIDFG + ++S G N
Sbjct: 684 -FQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFM---FESSPGGN 739
Query: 980 KERVPFV-LTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTG 1038
P + LT + + +MG GK + F+ F ++CV+ YLA+R + + ++ L ++ML TG
Sbjct: 740 LGWEPDIKLTDEMVMIMG--GKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTG 797
Query: 1039 MPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVC 1075
+P + I+ ++ + E +A + + I+ C
Sbjct: 798 LPCFRG-QTIKLLKHRFSPNMTEREAANFIMKVIQSC 833
>gi|155030226 phosphatidylinositol 4-kinase type 3 alpha isoform 2
[Homo sapiens]
Length = 2044
Score = 137 bits (345), Expect = 6e-32
Identities = 123/457 (26%), Positives = 218/457 (47%), Gaps = 40/457 (8%)
Query: 645 VQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIA 704
V+ L S D +L Y+ Q+VQA++++ + ++L +++ + H W +++ I
Sbjct: 1581 VKVLRSFPPDAILFYIPQIVQALRYDKM--GYVREYILWAASKSQLLAHQFIWNMKTNIY 1638
Query: 705 QSRHYQQRFAVI------LEAYLRGCGTAMLHDFTQ-QVQVIEMLQKVTLDIKSLSA--E 755
Q+ I L + G + DF Q + + V+ IK E
Sbjct: 1639 LDEEGHQKDPDIGDLLDQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDE 1698
Query: 756 KYDVSSQVISQLKQKL-----ENLQNSQLPESFR--VPYDPGLKAGALA---IEKCKVMA 805
+ +S++K + N + L ++ P KA LA +++C V
Sbjct: 1699 RKKACLSALSEVKVQPGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSE 1758
Query: 806 SKKKPLWL----EFKCADPTALSNETI--GIIFKHGDDLRQDMLILQILRIMESIWETES 859
+K+ L E +C+ A + IFK GDD RQDML LQI+ + ++I++
Sbjct: 1759 LEKEGLRCRSDSEDECSTQEADGQKISWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLVG 1818
Query: 860 LDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEE 919
LDL + PY ++T G+IE + D T+ ++ + T + G + D + E +
Sbjct: 1819 LDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQT--DFGMY-DYFTRQYGDESTLA-- 1873
Query: 920 KFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGIN 979
FQ A F+ S A Y + F+L I DRHN NIM+ + G++ HIDFG + ++S G N
Sbjct: 1874 -FQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFM---FESSPGGN 1929
Query: 980 KERVPFV-LTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTG 1038
P + LT + + +MG GK + F+ F ++CV+ YLA+R + + ++ L ++ML TG
Sbjct: 1930 LGWEPDIKLTDEMVMIMG--GKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTG 1987
Query: 1039 MPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVC 1075
+P + I+ ++ + E +A + + I+ C
Sbjct: 1988 LPCFRG-QTIKLLKHRFSPNMTEREAANFIMKVIQSC 2023
>gi|4505809 catalytic phosphatidylinositol 4-kinase beta [Homo
sapiens]
Length = 828
Score = 124 bits (310), Expect = 6e-28
Identities = 81/269 (30%), Positives = 140/269 (52%), Gaps = 14/269 (5%)
Query: 828 IGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATT 887
+ +I K GDDLRQ++L Q+L+ ++SIWE E + L + PY + GMIE V +A +
Sbjct: 571 LSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVS 630
Query: 888 IAKIQQSTVGNTGAFKDEVLNHWLKEK-SPTEEKFQAAVERFVYSCAGYCVATFVLGIGD 946
I ++++ + + +L+++L+E S T E F +A FV SCAGYC+ ++L + D
Sbjct: 631 IHQVKKQS-------QLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKD 683
Query: 947 RHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHF 1006
RHN NI++ G++ HIDFG IL + LG E F LT +F+ VM G F
Sbjct: 684 RHNGNILLDAEGHIIHIDFGFILSSSPRNLGF--ETSAFKLTTEFVDVM---GGLDGDMF 738
Query: 1007 QKFQDICVKAYLALRHHTNLLIILFSMMLM-TGMPQLTSKEDIEYIRDALTVGKNEEDAK 1065
++ + ++ +A R H + ++ + +M + +P I +++ + EE +
Sbjct: 739 NYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQ 798
Query: 1066 KYFLDQIEVCRDKGWTVQFNWFLHLVLGI 1094
++ T ++ F +L GI
Sbjct: 799 LLVEQMVDGSMRSITTKLYDGFQYLTNGI 827
>gi|239757646 PREDICTED: similar to phosphatidylinositol 4-kinase
type 3 alpha [Homo sapiens]
Length = 286
Score = 90.1 bits (222), Expect = 1e-17
Identities = 53/136 (38%), Positives = 79/136 (58%), Gaps = 6/136 (4%)
Query: 831 IFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAK 890
IFK GDD RQDML LQI+ + ++I++ LDL + PY ++T G+IE + D T+ +
Sbjct: 54 IFKLGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQ 113
Query: 891 IQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHND 950
+ + T + G + D + E + FQ A F+ S A Y + F+L I DRHN
Sbjct: 114 LGRQT--DFGMY-DYFTRQYGDESTLA---FQQARYNFIRSMAAYSLLLFLLQIKDRHNG 167
Query: 951 NIMITETGNLFHIDFG 966
NIM+ + G++ HIDFG
Sbjct: 168 NIMLDKKGHIIHIDFG 183
>gi|13654237 protein kinase, DNA-activated, catalytic polypeptide
isoform 1 [Homo sapiens]
Length = 4128
Score = 71.6 bits (174), Expect = 4e-12
Identities = 65/254 (25%), Positives = 105/254 (41%), Gaps = 63/254 (24%)
Query: 799 EKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETE 858
E+ VMAS ++P + + D + K G+DLRQD + Q+ ++M I +
Sbjct: 3724 ERVTVMASLRRPKRIIIRGHD-----EREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQD 3778
Query: 859 SL----DLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNT--------------- 899
S L L Y + ++G+IE +++ T+ + +T+
Sbjct: 3779 SACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTMSQEEKAAYLSDPRAPPCE 3838
Query: 900 ----------------------GAFKDEVLNHWLKEKSP---------------TEEKFQ 922
GA + E + + K +S + E F
Sbjct: 3839 YKDWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFL 3898
Query: 923 AAVERFVYSCAGYCVATFVLGIGDRHNDNIMIT-ETGNLFHIDFGHILGNYKSFLGINKE 981
A F S A C++ ++LGIGDRH +N M+ ETG + IDFGH G+ FL + E
Sbjct: 3899 ALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPV-PE 3957
Query: 982 RVPFVLTPDFLFVM 995
+PF LT F+ +M
Sbjct: 3958 LMPFRLTRQFINLM 3971
>gi|126032350 protein kinase, DNA-activated, catalytic polypeptide
isoform 2 [Homo sapiens]
Length = 4097
Score = 66.6 bits (161), Expect = 1e-10
Identities = 60/223 (26%), Positives = 92/223 (41%), Gaps = 32/223 (14%)
Query: 799 EKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETE 858
E+ VMAS ++P + + D + K G+DLRQD + Q+ ++M I +
Sbjct: 3724 ERVTVMASLRRPKRIIIRGHD-----EREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQD 3778
Query: 859 SL----DLCLLPYGCI---------------------STGDKIGMIEIVKDATTIAKIQQ 893
S L L Y + S +G ++ +
Sbjct: 3779 SACSQRALQLRTYSVVPMTSSDPRAPPCEYKDWLTKMSGKHDVGAYMLMYKGANRTETVT 3838
Query: 894 STVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIM 953
S ++L S + E F A F S A C++ ++LGIGDRH +N M
Sbjct: 3839 SFRKRESKVPADLLKRAFVRMSTSPEAFLALRSHFASSHALICISHWILGIGDRHLNNFM 3898
Query: 954 IT-ETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVM 995
+ ETG + IDFGH G+ FL + E +PF LT F+ +M
Sbjct: 3899 VAMETGGVIGIDFGHAFGSATQFLPV-PELMPFRLTRQFINLM 3940
>gi|113430845 PREDICTED: similar to protein kinase, DNA-activated,
catalytic polypeptide [Homo sapiens]
Length = 4096
Score = 66.6 bits (161), Expect = 1e-10
Identities = 60/223 (26%), Positives = 92/223 (41%), Gaps = 32/223 (14%)
Query: 799 EKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETE 858
E+ VMAS ++P + + D + K G+DLRQD + Q+ ++M I +
Sbjct: 3723 ERVTVMASLRRPKRIIIRGHD-----EREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQD 3777
Query: 859 SL----DLCLLPYGCI---------------------STGDKIGMIEIVKDATTIAKIQQ 893
S L L Y + S +G ++ +
Sbjct: 3778 SACSQRALQLRTYSVVPMTSSDPRAPPCEYKDWLTKMSGKHDVGAYMLMYKGANRTETVT 3837
Query: 894 STVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIM 953
S ++L S + E F A F S A C++ ++LGIGDRH +N M
Sbjct: 3838 SFRKRESKVPADLLKRAFVRMSTSPEAFLALRSHFASSHALICISHWILGIGDRHLNNFM 3897
Query: 954 IT-ETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVM 995
+ ETG + IDFGH G+ FL + E +PF LT F+ +M
Sbjct: 3898 VAMETGGVIGIDFGHAFGSATQFLPV-PELMPFRLTRQFINLM 3939
>gi|157266317 ataxia telangiectasia and Rad3 related protein [Homo
sapiens]
Length = 2644
Score = 54.3 bits (129), Expect = 6e-07
Identities = 52/234 (22%), Positives = 98/234 (41%), Gaps = 43/234 (18%)
Query: 802 KVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQ----ILRIMESIWET 857
+++AS +KP + K +D + ++ K DDLR+D +++ I + + E+
Sbjct: 2301 EILASLQKPKKISLKGSD-----GKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAES 2355
Query: 858 ESLDLCLLPYGCISTGDKIGMIEIVKDAT-----------------TIAKIQQSTVGNTG 900
+L + Y I D+ G+IE V + T +++Q + +
Sbjct: 2356 RRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSA 2415
Query: 901 AFKDE--------------VLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGD 946
A ++ + + W P + ++ + S A + ++LG+GD
Sbjct: 2416 ALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGD 2475
Query: 947 RHNDNIMITE-TGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSG 999
RH +NI+ TG H+DF + ++F E VPF LT + + MG G
Sbjct: 2476 RHGENILFDSLTGECVHVDFNCLFNKGETF--EVPEIVPFRLTHNMVNGMGPMG 2527
>gi|169165926 PREDICTED: similar to ataxia telangiectasia and Rad3
related protein, partial [Homo sapiens]
Length = 386
Score = 54.3 bits (129), Expect = 6e-07
Identities = 52/234 (22%), Positives = 98/234 (41%), Gaps = 43/234 (18%)
Query: 802 KVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQ----ILRIMESIWET 857
+++AS +KP + K +D + ++ K DDLR+D +++ I + + E+
Sbjct: 43 EILASLQKPKKISLKGSD-----GKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAES 97
Query: 858 ESLDLCLLPYGCISTGDKIGMIEIVKDAT-----------------TIAKIQQSTVGNTG 900
+L + Y I D+ G+IE V + T +++Q + +
Sbjct: 98 RRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSA 157
Query: 901 AFKDE--------------VLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGD 946
A ++ + + W P + ++ + S A + ++LG+GD
Sbjct: 158 ALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGD 217
Query: 947 RHNDNIMITE-TGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSG 999
RH +NI+ TG H+DF + ++F E VPF LT + + MG G
Sbjct: 218 RHGENILFDSLTGECVHVDFNCLFNKGETF--EVPEIVPFRLTHNMVNGMGPMG 269
>gi|20336199 ataxia telangiectasia mutated isoform 2 [Homo sapiens]
Length = 1708
Score = 51.2 bits (121), Expect = 5e-06
Identities = 62/249 (24%), Positives = 99/249 (39%), Gaps = 54/249 (21%)
Query: 831 IFKHGDDLRQDMLILQILRIMESIW----ETESLDLCLLPYGCISTGDKIGMIEIVKDAT 886
+ K DDLRQD ++ Q+ ++ ++ ET L + Y + + G++E T
Sbjct: 1367 LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEW---CT 1423
Query: 887 TIAKIQQSTVGNT-GAFKDEVLNHWLK----------EKSPTEEKFQAAVE--------- 926
I + V N GA K N + +K EEK++ ++
Sbjct: 1424 GTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVF 1483
Query: 927 -----------------RFVY--SCAGYCVATFVLGIGDRHNDNIMITE-TGNLFHIDFG 966
R Y S A + ++LG+GDRH NI+I E + L HID G
Sbjct: 1484 RYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLG 1543
Query: 967 HILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNL 1026
K + E VPF LT D + MG +G + F+ C K +R+
Sbjct: 1544 VAFEQGK--ILPTPETVPFRLTRDIVDGMGITGVE-----GVFRRCCEKTMEVMRNSQET 1596
Query: 1027 LIILFSMML 1035
L+ + ++L
Sbjct: 1597 LLTIVEVLL 1605
>gi|71902540 ataxia telangiectasia mutated isoform 1 [Homo sapiens]
Length = 3056
Score = 51.2 bits (121), Expect = 5e-06
Identities = 62/249 (24%), Positives = 99/249 (39%), Gaps = 54/249 (21%)
Query: 831 IFKHGDDLRQDMLILQILRIMESIW----ETESLDLCLLPYGCISTGDKIGMIEIVKDAT 886
+ K DDLRQD ++ Q+ ++ ++ ET L + Y + + G++E T
Sbjct: 2715 LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEW---CT 2771
Query: 887 TIAKIQQSTVGNT-GAFKDEVLNHWLK----------EKSPTEEKFQAAVE--------- 926
I + V N GA K N + +K EEK++ ++
Sbjct: 2772 GTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVF 2831
Query: 927 -----------------RFVY--SCAGYCVATFVLGIGDRHNDNIMITE-TGNLFHIDFG 966
R Y S A + ++LG+GDRH NI+I E + L HID G
Sbjct: 2832 RYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLG 2891
Query: 967 HILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNL 1026
K + E VPF LT D + MG +G + F+ C K +R+
Sbjct: 2892 VAFEQGK--ILPTPETVPFRLTRDIVDGMGITGVE-----GVFRRCCEKTMEVMRNSQET 2944
Query: 1027 LIILFSMML 1035
L+ + ++L
Sbjct: 2945 LLTIVEVLL 2953
>gi|169218268 PREDICTED: similar to Serine-protein kinase ATM, partial
[Homo sapiens]
Length = 2934
Score = 51.2 bits (121), Expect = 5e-06
Identities = 62/249 (24%), Positives = 99/249 (39%), Gaps = 54/249 (21%)
Query: 831 IFKHGDDLRQDMLILQILRIMESIW----ETESLDLCLLPYGCISTGDKIGMIEIVKDAT 886
+ K DDLRQD ++ Q+ ++ ++ ET L + Y + + G++E T
Sbjct: 2593 LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEW---CT 2649
Query: 887 TIAKIQQSTVGNT-GAFKDEVLNHWLK----------EKSPTEEKFQAAVE--------- 926
I + V N GA K N + +K EEK++ ++
Sbjct: 2650 GTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVF 2709
Query: 927 -----------------RFVY--SCAGYCVATFVLGIGDRHNDNIMITE-TGNLFHIDFG 966
R Y S A + ++LG+GDRH NI+I E + L HID G
Sbjct: 2710 RYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLG 2769
Query: 967 HILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNL 1026
K + E VPF LT D + MG +G + F+ C K +R+
Sbjct: 2770 VAFEQGK--ILPTPETVPFRLTRDIVDGMGITGVE-----GVFRRCCEKTMEVMRNSQET 2822
Query: 1027 LIILFSMML 1035
L+ + ++L
Sbjct: 2823 LLTIVEVLL 2831
>gi|4826730 FK506 binding protein 12-rapamycin associated protein 1
[Homo sapiens]
Length = 2549
Score = 44.7 bits (104), Expect = 5e-04
Identities = 58/259 (22%), Positives = 104/259 (40%), Gaps = 58/259 (22%)
Query: 786 PYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLIL 845
P P ++ ++A +V+ SK++P L ++ +E + ++ H +DLRQD ++
Sbjct: 2146 PNQPIIRIQSIA-PSLQVITSKQRPRKLTLMGSN----GHEFVFLLKGH-EDLRQDERVM 2199
Query: 846 QILRIMESIWETESL----DLCLLPYGCISTGDKIGMIEIVKDATTI------------- 888
Q+ ++ ++ + +L + Y I G+I V T+
Sbjct: 2200 QLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKI 2259
Query: 889 ------------------------AKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAA 924
++ + V NT A D WLK SP+ E +
Sbjct: 2260 LLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNT-AGDDLAKLLWLK--SPSSEVWFDR 2316
Query: 925 VERFVYSCAGYCVATFVLGIGDRHNDNIMITE-TGNLFHIDFG---HILGNYKSFLGINK 980
+ S A + ++LG+GDRH N+M+ +G + HIDFG + + F
Sbjct: 2317 RTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKF----P 2372
Query: 981 ERVPFVLTPDFLFVMGTSG 999
E++PF LT M +G
Sbjct: 2373 EKIPFRLTRMLTNAMEVTG 2391
>gi|62243658 PI-3-kinase-related kinase SMG-1 [Homo sapiens]
Length = 3661
Score = 44.7 bits (104), Expect = 5e-04
Identities = 25/84 (29%), Positives = 44/84 (52%), Gaps = 3/84 (3%)
Query: 917 TEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMI-TETGNLFHIDFGHILGNYKSF 975
T +++ + + S A + +++G+GDRH DN++I TG + HID+ KS
Sbjct: 2306 TPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKGKSL 2365
Query: 976 LGINKERVPFVLTPDFLFVMGTSG 999
E+VPF +T + +G +G
Sbjct: 2366 R--VPEKVPFRMTQNIETALGVTG 2387
>gi|33859670 leucine-rich repeats and calponin homology (CH) domain
containing 1 [Homo sapiens]
Length = 728
Score = 34.3 bits (77), Expect = 0.67
Identities = 33/121 (27%), Positives = 52/121 (42%), Gaps = 27/121 (22%)
Query: 448 ESPSSE--SKGKVQLLYYVNLLLI-----DHRFLLRRGEYVLHMWQISGKGEDQ---GSF 497
+SP ++ +KGKV + Y+++ D +L LH GK + GS
Sbjct: 269 QSPPAQICTKGKVHIFKYLSIQACQIKTADSLYLHTMERPHLHQHVEDGKKDSDSGVGSD 328
Query: 498 NADKLTSATNPDKENSMSISILLDNY-----------CHPIALPK------HQPTPDPEG 540
N DK SAT P E+++S+++ + N CH ++ K QP P G
Sbjct: 329 NGDKRLSATEPSDEDTVSLNVPMSNIMEEEQIIKEDSCHRLSPVKGEFHQEFQPEPSLLG 388
Query: 541 D 541
D
Sbjct: 389 D 389
>gi|62243696 stromal antigen 1 [Homo sapiens]
Length = 1258
Score = 33.1 bits (74), Expect = 1.5
Identities = 23/75 (30%), Positives = 38/75 (50%), Gaps = 4/75 (5%)
Query: 602 EIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIA--VQKLESLEDDDVLHY 659
E +KTY +L E Q+ +D+ + QL+D F D ++ +Q+ E +DDD+ +
Sbjct: 634 EACSKTYSILCSEEYTIQNRVDIARS-QLID-EFVDRFNHSVEDLLQEGEEADDDDIYNV 691
Query: 660 LLQLVQAVKFEPYHD 674
L L + F HD
Sbjct: 692 LSTLKRLTSFHNAHD 706
>gi|56550039 myeloid/lymphoid or mixed-lineage leukemia protein
[Homo sapiens]
Length = 3969
Score = 32.7 bits (73), Expect = 1.9
Identities = 15/43 (34%), Positives = 27/43 (62%), Gaps = 2/43 (4%)
Query: 566 PLTAEDKELLWH--FRYESLKHPKAYPKLFSSVKWGQQEIVAK 606
P+ + K +L FR+ SLKH ++ P+ FSS K+ ++ ++ K
Sbjct: 603 PMQGKRKSILREPTFRWTSLKHSRSEPQYFSSAKYAKEGLIRK 645
>gi|239751459 PREDICTED: dynein, axonemal, heavy chain 17 [Homo
sapiens]
Length = 4485
Score = 31.2 bits (69), Expect = 5.7
Identities = 40/177 (22%), Positives = 72/177 (40%), Gaps = 23/177 (12%)
Query: 292 WVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFT 351
W K ++ V+L P ++ VR ++P V +CT + +HE +++ +
Sbjct: 2900 WKFFIEKVRRQLKVILCFSPVGSVLRVRARKFPAVVNCTAIDWFHEW------PEDALVS 2953
Query: 352 VSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQV--LCQRR---TSPKPFTE 406
VS +F + GI V + +V + +V +RR T+PK F E
Sbjct: 2954 VS-----ARFLEETEGIPWEVKASISFFMSYVHTTVNEMSRVYLATERRYNYTTPKTFLE 3008
Query: 407 EV------LWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGK 457
++ L E KI+ L G L+ LQ + L +K + + + K +
Sbjct: 3009 QIKLYQNLLAKKRTELVAKIERLENG-LMKLQSTASQVDDLKAKLAIQEAELKQKNE 3064
>gi|239745966 PREDICTED: dynein, axonemal, heavy chain 17 [Homo
sapiens]
Length = 4485
Score = 31.2 bits (69), Expect = 5.7
Identities = 40/177 (22%), Positives = 72/177 (40%), Gaps = 23/177 (12%)
Query: 292 WVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFT 351
W K ++ V+L P ++ VR ++P V +CT + +HE +++ +
Sbjct: 2900 WKFFIEKVRRQLKVILCFSPVGSVLRVRARKFPAVVNCTAIDWFHEW------PEDALVS 2953
Query: 352 VSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQV--LCQRR---TSPKPFTE 406
VS +F + GI V + +V + +V +RR T+PK F E
Sbjct: 2954 VS-----ARFLEETEGIPWEVKASISFFMSYVHTTVNEMSRVYLATERRYNYTTPKTFLE 3008
Query: 407 EV------LWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGK 457
++ L E KI+ L G L+ LQ + L +K + + + K +
Sbjct: 3009 QIKLYQNLLAKKRTELVAKIERLENG-LMKLQSTASQVDDLKAKLAIQEAELKQKNE 3064
>gi|32171205 EF-hand domain family, member A2 [Homo sapiens]
Length = 530
Score = 31.2 bits (69), Expect = 5.7
Identities = 49/220 (22%), Positives = 89/220 (40%), Gaps = 38/220 (17%)
Query: 819 DPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGM 878
D T+L +T ++ G + ++ R M+++ +TE L++ L Y GM
Sbjct: 332 DITSLVTDTTLLVHFFGKKGKAELNFEDFYRFMDNL-QTEVLEIEFLSYSN-------GM 383
Query: 879 IEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVA 938
I ++ ++ + V NT F + V +EK T ++F++ + F+ + + +A
Sbjct: 384 NTISEEDFAHILLRYTNVENTSVFLENVRYSIPEEKGITFDEFRSFFQ-FLNNLEDFAIA 442
Query: 939 TFVLG-----IGDRHNDNIMITETG------------NLFHIDFGHILGNYKSFLGINKE 981
+ IG + TG +F +D L +YK F+GI K+
Sbjct: 443 LNMYNFASRSIGQDEFKRAVYVATGLKFSPHLVNTVFKIFDVDKDDQL-SYKEFIGIMKD 501
Query: 982 RVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALR 1021
R+ G G KT + F+ C+K L R
Sbjct: 502 RLH----------RGFRGYKTVQKYPTFKS-CLKKELHSR 530
>gi|190684679 hypothetical protein LOC126074 [Homo sapiens]
Length = 229
Score = 31.2 bits (69), Expect = 5.7
Identities = 29/93 (31%), Positives = 38/93 (40%), Gaps = 20/93 (21%)
Query: 18 RRRRRMKPRSAAASLSSMELIPIEFVLPTSQRK----------CKSPETALLHVAGHGNV 67
RR + PR +L M L I F P S R+ P +LL + G +
Sbjct: 42 RRPLQSMPRGTGTTLDPMRLQKIRFQYPPSTRELFRLLCSAHEAPGPAPSLLLLDG---L 98
Query: 68 EQMKAQ-------VWLRALETSVAADFYHRLGP 93
E+ A+ +L AL AA F HRLGP
Sbjct: 99 EEYLAEDPEPQEAAYLIALLLDTAAHFSHRLGP 131
>gi|239756957 PREDICTED: dynein, axonemal, heavy chain 17 [Homo
sapiens]
Length = 4470
Score = 30.8 bits (68), Expect = 7.4
Identities = 41/182 (22%), Positives = 71/182 (39%), Gaps = 34/182 (18%)
Query: 292 WVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFT 351
W K ++ V+L P ++ VR ++P V +CT + +HE
Sbjct: 2923 WKFFIEKVRRQLKVILCFSPVGSVLRVRARKFPAVVNCTAIDWFHE-------------- 2968
Query: 352 VSLWDCDRKFRVKIRGID----IPVLPRNTDLTV-FVEANIQHGQQV--LCQRR---TSP 401
W D V R ++ IPV+ + + +V + +V +RR T+P
Sbjct: 2969 ---WPEDALVSVSARFLEETEGIPVIKASISFFMSYVHTTVNEMSRVYLATERRYNYTTP 3025
Query: 402 KPFTEEV------LWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESK 455
K F E++ L E KI+ L G L+ LQ + L +K + + + K
Sbjct: 3026 KTFLEQIKLYQNLLAKKRTELVAKIERLENG-LMKLQSTASQVDDLKAKLAIQEAELKQK 3084
Query: 456 GK 457
+
Sbjct: 3085 NE 3086
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,356,912
Number of Sequences: 37866
Number of extensions: 1885972
Number of successful extensions: 4688
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 20
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 4582
Number of HSP's gapped (non-prelim): 57
length of query: 1102
length of database: 18,247,518
effective HSP length: 113
effective length of query: 989
effective length of database: 13,968,660
effective search space: 13815004740
effective search space used: 13815004740
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.