Search of human proteins with 211059435

Search of human proteins with 211059435

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|211059435 solute carrier family 22, member 24 [Homo sapiens]
         (551 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|211059435 solute carrier family 22, member 24 [Homo sapiens]      1099   0.0  
gi|148664184 solute carrier family 22, member 10 [Homo sapiens]       666   0.0  
gi|153791484 putative UST1-like organic anion transporter [Homo ...   625   e-179
gi|42542386 solute carrier family 22 (organic anion/cation trans...   620   e-177
gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]          482   e-136
gi|8923870 solute carrier family 22 member 11 [Homo sapiens]          452   e-127
gi|24497476 solute carrier family 22 member 6 isoform b [Homo sa...   413   e-115
gi|20070188 solute carrier family 22 member 6 isoform a [Homo sa...   408   e-114
gi|24497499 solute carrier family 22 member 8 [Homo sapiens]          378   e-105
gi|24497478 solute carrier family 22 member 6 isoform c [Homo sa...   370   e-102
gi|24497480 solute carrier family 22 member 6 isoform d [Homo sa...   365   e-101
gi|238814326 solute carrier family 22, member 20 [Homo sapiens]       362   e-100
gi|24497497 solute carrier family 22 member 7 isoform a [Homo sa...   291   8e-79
gi|90669191 solute carrier family 22 member 7 isoform b [Homo sa...   286   3e-77
gi|166064021 solute carrier family 22 (organic anion transporter...   284   2e-76
gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]          256   3e-68
gi|11415038 solute carrier family 22 member 3 [Homo sapiens]          216   6e-56
gi|4506999 solute carrier family 22 member 1 isoform a [Homo sap...   208   1e-53
gi|4507001 solute carrier family 22 member 2 [Homo sapiens]           205   1e-52
gi|169202895 PREDICTED: similar to solute carrier family 22, mem...   199   7e-51
gi|239750073 PREDICTED: similar to solute carrier family 22, mem...   199   7e-51
gi|239744382 PREDICTED: hypothetical protein XP_002343132 [Homo ...   199   7e-51
gi|4507005 solute carrier family 22 member 5 [Homo sapiens]           194   1e-49
gi|31542327 solute carrier family 22, member 16 [Homo sapiens]        191   1e-48
gi|24497490 solute carrier family 22 member 4 [Homo sapiens]          177   3e-44
gi|23510410 solute carrier family 22 member 1 isoform b [Homo sa...   176   5e-44
gi|157426885 organic cation transporter like 4 [Homo sapiens]         172   7e-43
gi|166197673 solute carrier family 22, member 15 [Homo sapiens]       144   3e-34
gi|63999576 solute carrier family 22, member 17 isoform b [Homo ...   113   4e-25
gi|170650643 solute carrier family 22, member 23 isoform a [Homo...   108   1e-23

>gi|211059435 solute carrier family 22, member 24 [Homo sapiens]
          Length = 551

 Score = 1099 bits (2843), Expect = 0.0
 Identities = 551/551 (100%), Positives = 551/551 (100%)

Query: 1   MGFDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVS 60
           MGFDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVS
Sbjct: 1   MGFDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVS 60

Query: 61  DNDTGTLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDGW 120
           DNDTGTLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDGW
Sbjct: 61  DNDTGTLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDGW 120

Query: 121 VYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCF 180
           VYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCF
Sbjct: 121 VYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCF 180

Query: 181 LQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLCS 240
           LQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLCS
Sbjct: 181 LQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLCS 240

Query: 241 YSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKELR 300
           YSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKELR
Sbjct: 241 YSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKELR 300

Query: 301 RVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRVFGLCFVRFAI 360
           RVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRVFGLCFVRFAI
Sbjct: 301 RVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRVFGLCFVRFAI 360

Query: 361 TVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQILFTFPVGLFI 420
           TVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQILFTFPVGLFI
Sbjct: 361 TVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQILFTFPVGLFI 420

Query: 421 LVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAGINAVSGRTGA 480
           LVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAGINAVSGRTGA
Sbjct: 421 LVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAGINAVSGRTGA 480

Query: 481 ALAPLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDVENEKDSRNIK 540
           ALAPLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDVENEKDSRNIK
Sbjct: 481 ALAPLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDVENEKDSRNIK 540

Query: 541 QEDTCMKVTQF 551
           QEDTCMKVTQF
Sbjct: 541 QEDTCMKVTQF 551


>gi|148664184 solute carrier family 22, member 10 [Homo sapiens]
          Length = 541

 Score =  666 bits (1718), Expect = 0.0
 Identities = 326/542 (60%), Positives = 417/542 (76%), Gaps = 2/542 (0%)

Query: 1   MGFDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVS 60
           M F+ LL QVGG+GRFQ+  + F   + +LL P+I+LENF A  P HRCWV +LDN+T S
Sbjct: 1   MAFEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGS 60

Query: 61  DNDTGTLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDGW 120
            N+TG LS+D LLRISIPLDSNLRP+KC+RF+HPQWQLLHLNGT  +T+E DTEPCVDGW
Sbjct: 61  GNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCVDGW 120

Query: 121 VYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCF 180
           VYD+S F STIVT+WDLVC+ QSLKS+VQ L + G L+GG+I GH+SDR GR+ I + C 
Sbjct: 121 VYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRWCL 180

Query: 181 LQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLCS 240
           LQLAI++TCAAFAPTF VYC+LRFLAGFS+M I+ N  +   EW  P S+++ +++   +
Sbjct: 181 LQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSSGA 240

Query: 241 YSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKELR 300
            S+GQ++LGGLA+  +DW  L +  S P  V FL S  +VESARWLII N+LDEGLK LR
Sbjct: 241 LSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALR 300

Query: 301 RVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRVFGLCFVRFAI 360
           +VA  NG KN EETL  E+VRSTM++ELDA + KT++  LFR P +R R+  L F+RFA 
Sbjct: 301 KVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILVFLRFAN 360

Query: 361 TVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQILFTFPVGLFI 420
           T+PFYG ++NLQH+GSN+ L Q+L GAV    RC++LLTLNHMGRRISQILF F VGL I
Sbjct: 361 TIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLSI 420

Query: 421 LVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAGINAVSGRTGA 480
           L NTF+P+EMQ LRV LA LGIG  +A  +S +VH  EL+PT+LR+  +GI+  + R GA
Sbjct: 421 LANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIGA 480

Query: 481 ALAPLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDVENEKDSRNIK 540
           ALAPLLMTL  +   LPWI YG+FPI+   ++ LLPET++LPLP+TI+DVEN+K  +N+K
Sbjct: 481 ALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVENQK--KNLK 538

Query: 541 QE 542
           ++
Sbjct: 539 EK 540


>gi|153791484 putative UST1-like organic anion transporter [Homo
           sapiens]
          Length = 547

 Score =  625 bits (1611), Expect = e-179
 Identities = 313/533 (58%), Positives = 390/533 (73%)

Query: 1   MGFDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVS 60
           M F  LLDQVGG+GRFQI  + F  + N++++    LENF AF   HRCWV +LDNDT+ 
Sbjct: 1   MAFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIP 60

Query: 61  DNDTGTLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDGW 120
           DND GTLS+D LLRISIP DSNLRP+KC+RF+HPQW+L+HLNGTFPNT+EPDTEPCVDGW
Sbjct: 61  DNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDTEPCVDGW 120

Query: 121 VYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCF 180
           VYD+SSF STIVT+WDLVCESQ L S+ + LFMAG ++GG +YGHLSDR GRK + +  +
Sbjct: 121 VYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKFVLRWSY 180

Query: 181 LQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLCS 240
           LQLAI  TCAAFAPT LVYC LRFLAG +T +I+ NT +L +EW   +  +M + + LC+
Sbjct: 181 LQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMALTLTLCA 240

Query: 241 YSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKELR 300
            S+G + LG LAF I+D  ILQL +S P  V FL S  + ESARWLIINN+ +EGLKELR
Sbjct: 241 ASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNKPEEGLKELR 300

Query: 301 RVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRVFGLCFVRFAI 360
           + AH NG KN E+ LT E+++STMK+EL+A + K S+  L R P +  R+  L FVRFA 
Sbjct: 301 KAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIPNICKRICFLSFVRFAS 360

Query: 361 TVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQILFTFPVGLFI 420
           T+PF+GL L+LQHLG+NV L Q L GAVT  A CV+   LNHM RR+SQ+L  F +   +
Sbjct: 361 TIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRLSQMLLMFLLATCL 420

Query: 421 LVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAGINAVSGRTGA 480
           L   F+PQEMQ LRVVLATLG+G+ S     ++   NEL+P+I+R    GI       G 
Sbjct: 421 LAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSIIRGRATGITGNFANIGG 480

Query: 481 ALAPLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDVENE 533
           ALA L+M L  YS  LPWI YGVF IL+  V+LLLPETR+ PL ++IQDVENE
Sbjct: 481 ALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSIQDVENE 533


>gi|42542386 solute carrier family 22 (organic anion/cation
           transporter), member 9 [Homo sapiens]
          Length = 553

 Score =  620 bits (1598), Expect = e-177
 Identities = 312/553 (56%), Positives = 398/553 (71%), Gaps = 2/553 (0%)

Query: 1   MGFDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVS 60
           M F  LL   G + RFQI    F  I  +  + + +LENFTAF P HRCWV +LDNDTVS
Sbjct: 1   MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVS 60

Query: 61  DNDTGTLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDGW 120
           DNDTG LS+D LLRISIPLDSN+RP+KC+RF+HPQWQLLHLNGTFPNT++ D EPCVDGW
Sbjct: 61  DNDTGALSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNTSDADMEPCVDGW 120

Query: 121 VYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCF 180
           VYDR SF STIVTEWDLVC+SQSL S+ + +FMAG ++GG++ GHLSDR GR+ + + C+
Sbjct: 121 VYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCY 180

Query: 181 LQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLCS 240
           LQ+AI  TCAA APTFL+YC LRFL+G + M+++ NT +L  EW   R ++M I + +C 
Sbjct: 181 LQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCP 240

Query: 241 YSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKELR 300
             +  M L GLAFAI+DWHILQL VS P  V+FL+S  ++ESARWLIINN+ +EGLKELR
Sbjct: 241 SGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKELR 300

Query: 301 RVAHINGKKNTEETLTTELVRSTMKKELDAV-RIKTSIFSLFRAPKLRMRVFGLCFVRFA 359
           + AH +G KN  +TLT E+++STMKKEL+A  + K S+  +   P +  R+  L F RFA
Sbjct: 301 KAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMPNICKRISLLSFTRFA 360

Query: 360 ITVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQILFTFPVGLF 419
             + ++GL L++QHLG+NV L Q L GAV   A CV+   L +M RR SQ+L  F + + 
Sbjct: 361 NFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAIC 420

Query: 420 ILVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAGINAVSGRTG 479
           +L   F+PQEMQ LR VLATLG+G+ + A+  A  H NE++PTI+R+   GINA      
Sbjct: 421 LLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIA 480

Query: 480 AALAPLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDVENE-KDSRN 538
            ALAPL+M L  YSP LPWI YGVFP ++    LLLPETR+ PL +TIQD +NE KD R 
Sbjct: 481 GALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTIQDEKNERKDPRE 540

Query: 539 IKQEDTCMKVTQF 551
            KQED  ++VTQF
Sbjct: 541 PKQEDPRVEVTQF 553


>gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]
          Length = 553

 Score =  482 bits (1240), Expect = e-136
 Identities = 256/555 (46%), Positives = 348/555 (62%), Gaps = 6/555 (1%)

Query: 1   MGFDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVS 60
           M F  LLD VGG+GRFQ+       ++ + L    +LENF+A  PSHRCW PLLDN T  
Sbjct: 1   MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ 60

Query: 61  DNDTGTLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDGW 120
            +  G+LS + LL ISIP   N RP +C+RF  PQWQLL  N T  + +E DTEPCVDGW
Sbjct: 61  ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW 120

Query: 121 VYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCF 180
           VYDRS F STIV +W+LVC+S +LK M QS+++AG L+G    G  SDR GR+++    +
Sbjct: 121 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY 180

Query: 181 LQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLCS 240
           LQ+A+  T AAFAP F VYC+ RFL  F+   ++ NT  L +EWT  R+R + + +    
Sbjct: 181 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG 240

Query: 241 YSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKELR 300
           +S G  L   +A+ ++DW +LQL VS P  + FL SW + ESARWL+   +LD GL+EL 
Sbjct: 241 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW 300

Query: 301 RVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMR--VFGLCFVRF 358
           RVA INGK   ++TLT E++ S M++EL   +   S+ +L R P LR R  +  LC+  F
Sbjct: 301 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF 360

Query: 359 AITVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQILFTFPVGL 418
             T  F+GL L+LQ LGSN+ L Q+  G V   A+  +LL L+H+GRR +        GL
Sbjct: 361 GFT--FFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGL 418

Query: 419 FILVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAGINAVSGRT 478
            IL NT +P EM  LR  LA LG+G V AA    +++ +EL PT+LR T  G+  ++ R 
Sbjct: 419 CILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARG 478

Query: 479 GAALAPLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDVENE--KDS 536
           GA L PL+  L  + P LP + YG  P+L+    LLLPET+ LPLP+TIQDV+N+  K +
Sbjct: 479 GAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKA 538

Query: 537 RNIKQEDTCMKVTQF 551
            +    ++ +K TQF
Sbjct: 539 THGTLGNSVLKSTQF 553


>gi|8923870 solute carrier family 22 member 11 [Homo sapiens]
          Length = 550

 Score =  452 bits (1162), Expect = e-127
 Identities = 245/538 (45%), Positives = 334/538 (62%), Gaps = 7/538 (1%)

Query: 1   MGFDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDT-V 59
           M F  LL+Q GG+G FQ   +  F +  +++   ++LENF+A  P HRCW  +LDN + V
Sbjct: 1   MAFSKLLEQAGGVGLFQTLQVLTFILPCLMIPSQMLLENFSAAIPGHRCWTHMLDNGSAV 60

Query: 60  SDNDTGTLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDG 119
           S N    ++   LL ISIP   N  P +C+RF  PQWQLL  N T  + +E DTEPCVDG
Sbjct: 61  STN----MTPKALLTISIPPGPNQGPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDG 116

Query: 120 WVYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLC 179
           WVYDRS F STIV +WDLVC SQ LK + QS+FM+G L+G  I+G LS R GRK +   C
Sbjct: 117 WVYDRSVFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRKPMLSWC 176

Query: 180 FLQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLC 239
            LQLA++ T   FAPTF++YC LRF+A F    I  ++  L +EWT    R++T+ V+ C
Sbjct: 177 CLQLAVAGTSTIFAPTFVIYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMTVVGC 236

Query: 240 SYSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKEL 299
           ++S GQ  LGGLAFA++DW  LQL  S P   + L SW + ESARWLII  + D+ L+EL
Sbjct: 237 AFSAGQAALGGLAFALRDWRTLQLAASVPFFAISLISWWLPESARWLIIKGKPDQALQEL 296

Query: 300 RRVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRVFGLCFVRFA 359
           R+VA ING K   + LT E++ S++K+E+ + +   S+  LF  P LR R   +  V F+
Sbjct: 297 RKVARINGHKEA-KNLTIEVLMSSVKEEVASAKEPRSVLDLFCVPVLRWRSCAMLVVNFS 355

Query: 360 ITVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQILFTFPVGLF 419
           + + +YGL+ +LQ LG ++ L Q L GAV F  R  + L L+ +GRR  Q       GL 
Sbjct: 356 LLISYYGLVFDLQSLGRDIFLLQALFGAVDFLGRATTALLLSFLGRRTIQAGSQAMAGLA 415

Query: 420 ILVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAGINAVSGRTG 479
           IL N  +PQ++Q LRVV A LG G    +    +++  EL PT +R T  GI    GR G
Sbjct: 416 ILANMLVPQDLQTLRVVFAVLGKGCFGISLTCLTIYKAELFPTPVRMTADGILHTVGRLG 475

Query: 480 AALAPLLMTLMAYSPHLPWISYGVFPILAVPVIL-LLPETRDLPLPNTIQDVENEKDS 536
           A + PL++      P LP + YGV  I +  V+L  LPET+ LPLP+TIQD+E++K +
Sbjct: 476 AMMGPLILMSRQALPLLPPLLYGVISIASSLVVLFFLPETQGLPLPDTIQDLESQKST 533


>gi|24497476 solute carrier family 22 member 6 isoform b [Homo
           sapiens]
          Length = 550

 Score =  413 bits (1061), Expect = e-115
 Identities = 219/543 (40%), Positives = 323/543 (59%), Gaps = 11/543 (2%)

Query: 1   MGFDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVS 60
           M F+ LL QVGG+GRFQ   +    +  +L+  +  L+NFTA  P+H C  P   N    
Sbjct: 1   MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADAN---- 56

Query: 61  DNDTGTLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDGW 120
                 LSK+  L + +P D   +P+ C RF  PQW L  LNGT  N     TEPC DGW
Sbjct: 57  ------LSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGA-TEPCTDGW 109

Query: 121 VYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCF 180
           +YD S+F STIVTEWDLVC  ++L+ + QSL+M G LLG +++G+L+DR+GR+ +  L +
Sbjct: 110 IYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNY 169

Query: 181 LQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLCS 240
           LQ A+S TCAAFAP F +YC  R L+G +   I  N   L++EW    +R+    ++   
Sbjct: 170 LQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYV 229

Query: 241 YSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKELR 300
           YS+GQ LL G+A+A+  W  LQL VS P    F+ SW  +ESARW   + +LD  L+ L+
Sbjct: 230 YSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQ 289

Query: 301 RVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRVFGLCFVRFAI 360
           RVA INGK+     L+ E++R++++KEL   + + S   L R P LR     L  + FA 
Sbjct: 290 RVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFAT 349

Query: 361 TVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQILFTFPVGLFI 420
           +  +YGL+++LQ  G ++ L Q++ GAV   A+ V  L +N +GRR +Q+      G+ I
Sbjct: 350 SFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICI 409

Query: 421 LVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAGINAVSGRTGA 480
           L+N  +PQ+  I+R  LA LG G ++A+ N   ++  EL PT++R T  G+ +   R G+
Sbjct: 410 LLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGS 469

Query: 481 ALAPLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDVENEKDSRNIK 540
            ++PL+       P +P   YG  P+ A  V +LLPET   PLP+T+QD+E+ K  +  +
Sbjct: 470 IVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRKGKQTRQ 529

Query: 541 QED 543
           Q++
Sbjct: 530 QQE 532


>gi|20070188 solute carrier family 22 member 6 isoform a [Homo
           sapiens]
          Length = 563

 Score =  408 bits (1049), Expect = e-114
 Identities = 217/532 (40%), Positives = 317/532 (59%), Gaps = 11/532 (2%)

Query: 1   MGFDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVS 60
           M F+ LL QVGG+GRFQ   +    +  +L+  +  L+NFTA  P+H C  P   N    
Sbjct: 1   MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADAN---- 56

Query: 61  DNDTGTLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDGW 120
                 LSK+  L + +P D   +P+ C RF  PQW L  LNGT  N     TEPC DGW
Sbjct: 57  ------LSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGA-TEPCTDGW 109

Query: 121 VYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCF 180
           +YD S+F STIVTEWDLVC  ++L+ + QSL+M G LLG +++G+L+DR+GR+ +  L +
Sbjct: 110 IYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNY 169

Query: 181 LQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLCS 240
           LQ A+S TCAAFAP F +YC  R L+G +   I  N   L++EW    +R+    ++   
Sbjct: 170 LQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYV 229

Query: 241 YSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKELR 300
           YS+GQ LL G+A+A+  W  LQL VS P    F+ SW  +ESARW   + +LD  L+ L+
Sbjct: 230 YSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQ 289

Query: 301 RVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRVFGLCFVRFAI 360
           RVA INGK+     L+ E++R++++KEL   + + S   L R P LR     L  + FA 
Sbjct: 290 RVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFAT 349

Query: 361 TVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQILFTFPVGLFI 420
           +  +YGL+++LQ  G ++ L Q++ GAV   A+ V  L +N +GRR +Q+      G+ I
Sbjct: 350 SFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICI 409

Query: 421 LVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAGINAVSGRTGA 480
           L+N  +PQ+  I+R  LA LG G ++A+ N   ++  EL PT++R T  G+ +   R G+
Sbjct: 410 LLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGS 469

Query: 481 ALAPLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDVEN 532
            ++PL+       P +P   YG  P+ A  V +LLPET   PLP+T+QD+E+
Sbjct: 470 IVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLES 521


>gi|24497499 solute carrier family 22 member 8 [Homo sapiens]
          Length = 542

 Score =  378 bits (970), Expect = e-105
 Identities = 215/551 (39%), Positives = 312/551 (56%), Gaps = 24/551 (4%)

Query: 1   MGFDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVS 60
           M F  +LD+VG MG FQ   +A   +  + +  + +L+ FTA TP H C  P        
Sbjct: 1   MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPP-------H 53

Query: 61  DNDTGTLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDGW 120
           +  TG           +P+  N +P++C RF+HP       N + PN  +   EPC+DGW
Sbjct: 54  NASTGPWV--------LPMGPNGKPERCLRFVHPP------NASLPNDTQRAMEPCLDGW 99

Query: 121 VYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCF 180
           VY+ +    +IVTEWDLVC S  LK M QS+FMAG L+GGL+ G LSDR GR+ I    +
Sbjct: 100 VYNSTK--DSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSY 157

Query: 181 LQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLCS 240
           L LA S + AAF+PTF +Y + RFL GF    I  +T IL++EW   R R++    L   
Sbjct: 158 LLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYC 217

Query: 241 YSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKELR 300
           Y+ GQ +L GLA+AI  W  LQLTVS P  V FLSSW   ES RWL+++ +  + LK LR
Sbjct: 218 YTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILR 277

Query: 301 RVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRVFGLCFVRFAI 360
           RVA  NGKK   E L+ E ++  ++KE+   + K +   LFR P LR   F L    FA 
Sbjct: 278 RVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFAT 337

Query: 361 TVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQILFTFPVGLFI 420
              +Y L + ++  G N+ + QI+ G V   A+ +++L+L+++GR  +Q       G  I
Sbjct: 338 GFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAI 397

Query: 421 LVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAGINAVSGRTGA 480
           L  TF+P ++Q +R VLA  G G +S++ +   ++ +EL PT++R T  G++ +  R G+
Sbjct: 398 LALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGS 457

Query: 481 ALAPLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDVEN-EKDSRNI 539
            ++PL+       P +P I YG+  +L     L LPET + PLP TI+D+EN    ++  
Sbjct: 458 MVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKP 517

Query: 540 KQEDTCMKVTQ 550
           KQE    K +Q
Sbjct: 518 KQEPEVEKASQ 528


>gi|24497478 solute carrier family 22 member 6 isoform c [Homo
           sapiens]
          Length = 506

 Score =  370 bits (949), Expect = e-102
 Identities = 207/543 (38%), Positives = 304/543 (55%), Gaps = 55/543 (10%)

Query: 1   MGFDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVS 60
           M F+ LL QVGG+GRFQ   +    +  +L+  +  L+NFTA  P+H C  P   N    
Sbjct: 1   MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADAN---- 56

Query: 61  DNDTGTLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDGW 120
                 LSK+  L + +P D   +P+ C RF  PQW L  LNGT  N     TEPC DGW
Sbjct: 57  ------LSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGA-TEPCTDGW 109

Query: 121 VYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCF 180
           +YD S+F STIVTEWDLVC  ++L+ + QSL+M G LLG +++G+L+DR+GR+ +  L +
Sbjct: 110 IYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNY 169

Query: 181 LQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLCS 240
           LQ A+S TCAAFAP F +YC  R L+G +   I  N   L++EW    +R+    ++   
Sbjct: 170 LQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYV 229

Query: 241 YSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKELR 300
           YS+GQ LL G+A+A+  W  LQL VS P    F+ SW  +ESARW   + +LD  L+ L+
Sbjct: 230 YSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQ 289

Query: 301 RVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRVFGLCFVRFAI 360
           RVA INGK+     L+ E++R++++KEL   + + S   L R P LR     L  + FA 
Sbjct: 290 RVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFAT 349

Query: 361 TVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQILFTFPVGLFI 420
           +  +YGL+++LQ  G ++ L Q++ GAV   A+ V  L +N +GRR +Q+      G+ I
Sbjct: 350 SFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICI 409

Query: 421 LVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAGINAVSGRTGA 480
           L+N  +PQ+  I+R  LA LG G ++A+ N   ++  EL PT++R+              
Sbjct: 410 LLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRA-------------- 455

Query: 481 ALAPLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDVENEKDSRNIK 540
                                         V +LLPET   PLP+T+QD+E+ K  +  +
Sbjct: 456 ------------------------------VTVLLPETLGQPLPDTVQDLESRKGKQTRQ 485

Query: 541 QED 543
           Q++
Sbjct: 486 QQE 488


>gi|24497480 solute carrier family 22 member 6 isoform d [Homo
           sapiens]
          Length = 519

 Score =  365 bits (937), Expect = e-101
 Identities = 205/532 (38%), Positives = 298/532 (56%), Gaps = 55/532 (10%)

Query: 1   MGFDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVS 60
           M F+ LL QVGG+GRFQ   +    +  +L+  +  L+NFTA  P+H C  P   N    
Sbjct: 1   MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADAN---- 56

Query: 61  DNDTGTLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDGW 120
                 LSK+  L + +P D   +P+ C RF  PQW L  LNGT  N     TEPC DGW
Sbjct: 57  ------LSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGA-TEPCTDGW 109

Query: 121 VYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCF 180
           +YD S+F STIVTEWDLVC  ++L+ + QSL+M G LLG +++G+L+DR+GR+ +  L +
Sbjct: 110 IYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNY 169

Query: 181 LQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLCS 240
           LQ A+S TCAAFAP F +YC  R L+G +   I  N   L++EW    +R+    ++   
Sbjct: 170 LQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYV 229

Query: 241 YSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKELR 300
           YS+GQ LL G+A+A+  W  LQL VS P    F+ SW  +ESARW   + +LD  L+ L+
Sbjct: 230 YSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQ 289

Query: 301 RVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRVFGLCFVRFAI 360
           RVA INGK+     L+ E++R++++KEL   + + S   L R P LR     L  + FA 
Sbjct: 290 RVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFAT 349

Query: 361 TVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQILFTFPVGLFI 420
           +  +YGL+++LQ  G ++ L Q++ GAV   A+ V  L +N +GRR +Q+      G+ I
Sbjct: 350 SFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICI 409

Query: 421 LVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAGINAVSGRTGA 480
           L+N  +PQ+  I+R  LA LG G ++A+ N   ++  EL PT++R+              
Sbjct: 410 LLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRA-------------- 455

Query: 481 ALAPLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDVEN 532
                                         V +LLPET   PLP+T+QD+E+
Sbjct: 456 ------------------------------VTVLLPETLGQPLPDTVQDLES 477


>gi|238814326 solute carrier family 22, member 20 [Homo sapiens]
          Length = 555

 Score =  362 bits (930), Expect = e-100
 Identities = 206/531 (38%), Positives = 305/531 (57%), Gaps = 9/531 (1%)

Query: 1   MGFDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVS 60
           M F  LLD +G MGRFQ+   A   +   LL  +  L+NFTA  P H C  P  ++   S
Sbjct: 1   MAFTDLLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHCRGPA-NHTEAS 59

Query: 61  DNDTGTLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDGW 120
            ND+G       LR +IPLD    P+ C+RF  PQW LL  N + P      TE C DGW
Sbjct: 60  TNDSGAW-----LRATIPLDQLGAPEPCRRFTKPQWALLSPNSSIPGAA---TEGCKDGW 111

Query: 121 VYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCF 180
           VY+RS F STIV EWDLVCE+++L+ + QS++MAG L+G  ++G L+DR+G K      +
Sbjct: 112 VYNRSVFPSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSY 171

Query: 181 LQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLCS 240
           LQLA S    A+  +F  YC+ RFL G +   I+ N+  L +EW   R R++  ++L  S
Sbjct: 172 LQLAASGAATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGILLGYS 231

Query: 241 YSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKELR 300
           +++GQ++L G+A+ I+ W  LQ  +S P ++ FL SW + ES+RWL+++ +    ++ L+
Sbjct: 232 FTLGQLILAGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNLQ 291

Query: 301 RVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRVFGLCFVRFAI 360
           +VA +NG+K   E LT E++ S ++ E  +V    SI  LFR P +R     L  + F+ 
Sbjct: 292 KVAAMNGRKEEGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLMVIWFSN 351

Query: 361 TVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQILFTFPVGLFI 420
           +V +YGL ++LQ  G ++ L Q L G +   A  V+  T+ ++GRR +   F    GL +
Sbjct: 352 SVAYYGLAMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAGLMV 411

Query: 421 LVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAGINAVSGRTGA 480
           + N F+P+  QIL    A LG G ++++     +   EL PT +R    G  +V  R G 
Sbjct: 412 IANMFVPEGTQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVHARLGG 471

Query: 481 ALAPLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDVE 531
             APL+ TL  YS  LP +S+G   ILA   + +L ETR++PL  TI  +E
Sbjct: 472 LTAPLVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAME 522


>gi|24497497 solute carrier family 22 member 7 isoform a [Homo
           sapiens]
          Length = 546

 Score =  291 bits (746), Expect = 8e-79
 Identities = 188/564 (33%), Positives = 278/564 (49%), Gaps = 33/564 (5%)

Query: 1   MGFDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVS 60
           MGF+ LL+QVGG G FQ+  +A   +  +LL  + +L  F A  P+HRC +P        
Sbjct: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALP-------- 52

Query: 61  DNDTGTLSKDDL-LRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNT----------- 108
                  S  D+ L   +P + +     C RF +PQ          PNT           
Sbjct: 53  -GAPANFSHQDVWLEAHLPREPDGTLSSCLRFAYPQ--------ALPNTTLGEERQSRGE 103

Query: 109 --NEPDTEPCVDGWVYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHL 166
             +EP T PC  GW YD S F STI TEWDLVCE + L     + F AG L+G + +G+L
Sbjct: 104 LEDEPATVPCSQGWEYDHSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYL 163

Query: 167 SDRVGRKIICKLCFLQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTL 226
           SDR GR+ +  + ++   +    +A + +++++ I R L G +          L LEW  
Sbjct: 164 SDRFGRRRLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLD 223

Query: 227 PRSRSMTIMVLLCSYSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWL 286
              R++  ++    ++ G MLL  + + I+DW  L L V+ P     LS W + ESARWL
Sbjct: 224 VEHRTVAGVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWL 283

Query: 287 IINNQLDEGLKELRRVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKL 346
           +    + E  + L   A +NG+   E++ + E V      E   V  + S   LFR P+L
Sbjct: 284 LTQGHVKEAHRYLLHCARLNGRPVCEDSFSQEAVSKVAAGE--RVVRRPSYLDLFRTPRL 341

Query: 347 RMRVFGLCFVRFAITVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRR 406
           R        V F +   +YGL L++  LG NV   Q+L GAV   ++ +  L++ + GRR
Sbjct: 342 RHISLCCVVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRR 401

Query: 407 ISQILFTFPVGLFILVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRS 466
           ++Q        L       +  +M+    VLA +G     AA  +A +  +EL PT+LR 
Sbjct: 402 LTQAGTLLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQ 461

Query: 467 TVAGINAVSGRTGAALAPLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNT 526
           T  G+ A+ GR G +LAPL   L      LP ++YG   +LA    LLLPETR   LP T
Sbjct: 462 TGMGLTALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPET 521

Query: 527 IQDVENEKDSRNIKQEDTCMKVTQ 550
           IQDVE +    ++++E+  MK  Q
Sbjct: 522 IQDVERKSAPTSLQEEEMPMKQVQ 545


>gi|90669191 solute carrier family 22 member 7 isoform b [Homo
           sapiens]
          Length = 548

 Score =  286 bits (733), Expect = 3e-77
 Identities = 188/566 (33%), Positives = 278/566 (49%), Gaps = 35/566 (6%)

Query: 1   MGFDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVS 60
           MGF+ LL+QVGG G FQ+  +A   +  +LL  + +L  F A  P+HRC +P        
Sbjct: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALP-------- 52

Query: 61  DNDTGTLSKDDL-LRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNT----------- 108
                  S  D+ L   +P + +     C RF +PQ          PNT           
Sbjct: 53  -GAPANFSHQDVWLEAHLPREPDGTLSSCLRFAYPQ--------ALPNTTLGEERQSRGE 103

Query: 109 --NEPDTEPCVDGWVYDRSSFLSTIVTE--WDLVCESQSLKSMVQSLFMAGSLLGGLIYG 164
             +EP T PC  GW YD S F STI TE  WDLVCE + L     + F AG L+G + +G
Sbjct: 104 LEDEPATVPCSQGWEYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFG 163

Query: 165 HLSDRVGRKIICKLCFLQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEW 224
           +LSDR GR+ +  + ++   +    +A + +++++ I R L G +          L LEW
Sbjct: 164 YLSDRFGRRRLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEW 223

Query: 225 TLPRSRSMTIMVLLCSYSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESAR 284
                R++  ++    ++ G MLL  + + I+DW  L L V+ P     LS W + ESAR
Sbjct: 224 LDVEHRTVAGVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESAR 283

Query: 285 WLIINNQLDEGLKELRRVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAP 344
           WL+    + E  + L   A +NG+   E++ + E V      E   V  + S   LFR P
Sbjct: 284 WLLTQGHVKEAHRYLLHCARLNGRPVCEDSFSQEAVSKVAAGE--RVVRRPSYLDLFRTP 341

Query: 345 KLRMRVFGLCFVRFAITVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMG 404
           +LR        V F +   +YGL L++  LG NV   Q+L GAV   ++ +  L++ + G
Sbjct: 342 RLRHISLCCVVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAG 401

Query: 405 RRISQILFTFPVGLFILVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTIL 464
           RR++Q        L       +  +M+    VLA +G     AA  +A +  +EL PT+L
Sbjct: 402 RRLTQAGTLLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVL 461

Query: 465 RSTVAGINAVSGRTGAALAPLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLP 524
           R T  G+ A+ GR G +LAPL   L      LP ++YG   +LA    LLLPETR   LP
Sbjct: 462 RQTGMGLTALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLP 521

Query: 525 NTIQDVENEKDSRNIKQEDTCMKVTQ 550
            TIQDVE +    ++++E+  MK  Q
Sbjct: 522 ETIQDVERKSAPTSLQEEEMPMKQVQ 547


>gi|166064021 solute carrier family 22 (organic anion transporter),
           member 13 [Homo sapiens]
          Length = 551

 Score =  284 bits (726), Expect = 2e-76
 Identities = 175/529 (33%), Positives = 276/529 (52%), Gaps = 17/529 (3%)

Query: 3   FDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVSDN 62
           F  +L ++G  GRFQI L+   C+ N L         F      H C V  + N T +  
Sbjct: 4   FVQVLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTFN-- 61

Query: 63  DTGTLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDGWVY 122
               LS  + L +S+PLD+   P+ C  F  P       +      NE  T+PC  GW Y
Sbjct: 62  ----LSAAEQLVLSVPLDTAGHPEPCLMFRPPPANASLQDILSHRFNE--TQPCDMGWEY 115

Query: 123 DRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCFLQ 182
             +  L ++  E++LVC+ + LK   QS+FMAG L+G L++G L DR+GRK       L 
Sbjct: 116 PENR-LPSLKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLL 174

Query: 183 LAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLCSYS 242
             +     AF P+F +Y  LRF    +   +  +   L  EW  P  R+  +++  C++S
Sbjct: 175 FTLIGLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFS 234

Query: 243 VGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKELRRV 302
           +GQM+L GLA+  ++W +LQ+T + P ++LF   W + ESARWL+   ++DE ++ +++ 
Sbjct: 235 LGQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKA 294

Query: 303 AHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRVFGLCFVRFAITV 362
           A +N +K     L+ EL+   + ++        +   LFR P+LR     +  V F  ++
Sbjct: 295 ASVNRRK-----LSPELMNQLVPEKTGP---SGNALDLFRHPQLRKVTLIIFCVWFVDSL 346

Query: 363 PFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQILFTFPVGLFILV 422
            +YGL L +   G +V L Q++ GAV   ARC S+  +   GR+ SQ+      GL  ++
Sbjct: 347 GYYGLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCII 406

Query: 423 NTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAGINAVSGRTGAAL 482
             F+P ++ ++  +LA +G  + +AA   + V+  EL PTILR T  G+  +  R G  L
Sbjct: 407 IIFIPADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGIL 466

Query: 483 APLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDVE 531
            PL++ L  Y   LP + YG  PI+A  +  LLPET    L +T+QD+E
Sbjct: 467 TPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLE 515


>gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]
          Length = 332

 Score =  256 bits (655), Expect = 3e-68
 Identities = 143/334 (42%), Positives = 203/334 (60%), Gaps = 6/334 (1%)

Query: 222 LEWTLPRSRSMTIMVLLCSYSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVE 281
           +EWT  R+R + + +    +S G  L   +A+ ++DW +LQL VS P  + FL SW + E
Sbjct: 1   MEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAE 60

Query: 282 SARWLIINNQLDEGLKELRRVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLF 341
           SARWL+   +LD GL+EL RVA INGK   ++TLT E++ S M++EL   +   S+ +L 
Sbjct: 61  SARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLL 120

Query: 342 RAPKLRMR--VFGLCFVRFAITVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLT 399
           R P LR R  +  LC+  F  T  F+GL L+LQ LGSN+ L Q+  G V   A+  +LL 
Sbjct: 121 RMPGLRFRTCISTLCWFAFGFT--FFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLL 178

Query: 400 LNHMGRRISQILFTFPVGLFILVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNEL 459
           L+H+GRR +        GL IL NT +P EM  LR  LA LG+G V AA    +++ +EL
Sbjct: 179 LSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSEL 238

Query: 460 VPTILRSTVAGINAVSGRTGAALAPLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETR 519
            PT+LR T  G+  ++ R GA L PL+  L  + P LP + YG  P+L+    LLLPET+
Sbjct: 239 FPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQ 298

Query: 520 DLPLPNTIQDVENE--KDSRNIKQEDTCMKVTQF 551
            LPLP+TIQDV+N+  K + +    ++ +K TQF
Sbjct: 299 SLPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF 332


>gi|11415038 solute carrier family 22 member 3 [Homo sapiens]
          Length = 556

 Score =  216 bits (549), Expect = 6e-56
 Identities = 166/554 (29%), Positives = 258/554 (46%), Gaps = 49/554 (8%)

Query: 3   FDVLLDQVGGMGRFQICLIAFFCITNI---LLFPNIVLENFTAFTPSHR-CWVPLLDNDT 58
           FD  L +VG  GRFQ  +    C+T +    LF  +V   F    P H  C  P      
Sbjct: 4   FDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVV---FLGTQPDHYWCRGP----SA 56

Query: 59  VSDNDTGTLSKDDLLRISIPLDSNLRPQ----KCQRFI----------HPQWQLLHLNGT 104
            +  +    S ++    + P      P     +CQR++                      
Sbjct: 57  AALAERCGWSPEEEWNRTAPASRGPEPPERRGRCQRYLLEAANDSASATSALSCADPLAA 116

Query: 105 FPNTNEPDTEPCVDGWVYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYG 164
           FPN + P   PC  GW Y ++   STIV+E+DLVC +  +  + Q++   G L G    G
Sbjct: 117 FPNRSAP-LVPCRGGWRYAQAH--STIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLG 173

Query: 165 HLSDRVGRKIICKLCFLQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEW 224
           + +DR GR +I  L  L + ++    AFAP F V+ I RFL G          +++  E 
Sbjct: 174 YAADRYGRIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEI 233

Query: 225 TLPRSRSMTIMVLLCSYSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESAR 284
              + R +  +V+   +++G ++L G+A+ I +W  +QL ++ P  +  L  W + ES R
Sbjct: 234 VGSKQRRIVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPR 293

Query: 285 WLIINNQLDEGLKELRRVAHINGK----KNTEETLTTELVRSTMKKELDAVRIKTSIFSL 340
           WLI   + D+ L+ LRR+A  NGK      +E T+T E V +             S   L
Sbjct: 294 WLITRKKGDKALQILRRIAKCNGKYLSSNYSEITVTDEEVSNP------------SFLDL 341

Query: 341 FRAPKLRMRVFGLCFVRFAITVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTL 400
            R P++R     L F  F   V + GL++ L  +G N+ +   + G V      + LLT+
Sbjct: 342 VRTPQMRKCTLILMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTI 401

Query: 401 NHMGRRISQILFTFPVGLFILVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELV 460
             +GRR+         G+  LV  FLP+ +  LR  +ATLG   ++ A     + ++EL 
Sbjct: 402 ERLGRRLPFAASNIVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELY 461

Query: 461 PTILRSTVAGINAVSGRT--GAALAP-LLMTLMAYSPHLPWISYGVFPILAVPVILLLPE 517
           PT LR+   G++  SG    G  +AP LL  L A    LP I +G+   +   +++LLPE
Sbjct: 462 PTTLRN--FGVSLCSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPE 519

Query: 518 TRDLPLPNTIQDVE 531
           T+ + LP T+ DVE
Sbjct: 520 TKGIALPETVDDVE 533


>gi|4506999 solute carrier family 22 member 1 isoform a [Homo
           sapiens]
          Length = 554

 Score =  208 bits (529), Expect = 1e-53
 Identities = 160/558 (28%), Positives = 248/558 (44%), Gaps = 29/558 (5%)

Query: 4   DVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVSDND 63
           D +L+QVG  G FQ       C+ +    P  V   F  FTP H C  P         + 
Sbjct: 5   DDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSP----GVAELSQ 60

Query: 64  TGTLSKDDLLRISIPLDSNLRPQ------KCQRFIHPQWQLLHLNGTFP------NTNEP 111
               S  + L  ++P    L P       +C+R+    W    L+   P      N +  
Sbjct: 61  RCGWSPAEELNYTVP---GLGPAGEAFLGQCRRY-EVDWNQSALSCVDPLASLATNRSHL 116

Query: 112 DTEPCVDGWVYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVG 171
              PC DGWVYD     S+IVTE++LVC       + QS   AG L G L  G+ +DR G
Sbjct: 117 PLGPCQDGWVYDTPG--SSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFG 174

Query: 172 RKIICKLCFLQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRS 231
           RK+      L  A+S    AF+P ++   + R L G  +       + L  E+    SR 
Sbjct: 175 RKLCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRR 234

Query: 232 MTIMVLLCSYSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQ 291
              ++   +++VG + L GLA+A+  W  LQL VS P  +  L  W + ES RWL+   +
Sbjct: 235 TVAIMYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKR 294

Query: 292 LDEGLKELRRVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRVF 351
             E +K +  +A  NGK    +     L     +K      +  S   LFR P+LR R F
Sbjct: 295 NTEAIKIMDHIAQKNGKLPPADLKMLSLEEDVTEK------LSPSFADLFRTPRLRKRTF 348

Query: 352 GLCFVRFAITVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQIL 411
            L ++ F  +V + GLIL++     N+ L  +    V      ++L+T++ +GR     +
Sbjct: 349 ILMYLWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAM 408

Query: 412 FTFPVGLFILVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAGI 471
                G   LV  F+  ++  L +++  +G   ++ A     + + EL PT +R+    +
Sbjct: 409 SNLLAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMV 468

Query: 472 NAVSGRTGAALAP-LLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDV 530
            +     G  + P ++  L      LP I + V  +LA  V LLLPET+ + LP T++D 
Sbjct: 469 CSSLCDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDA 528

Query: 531 ENEKDSRNIKQEDTCMKV 548
           EN       K+    +KV
Sbjct: 529 ENLGRKAKPKENTIYLKV 546


>gi|4507001 solute carrier family 22 member 2 [Homo sapiens]
          Length = 555

 Score =  205 bits (521), Expect = 1e-52
 Identities = 154/555 (27%), Positives = 259/555 (46%), Gaps = 23/555 (4%)

Query: 4   DVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVSDND 63
           D +L+  G    FQ  +     + +    P  V   F  FTP HRC  P +   ++    
Sbjct: 6   DDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELSLRCG- 64

Query: 64  TGTLSKDDLLRISIPLDS---NLRPQKCQRFIHPQWQLLHLNGTFP------NTNEPDTE 114
               S  + L  ++P         P++C+R+    W     +   P      N +     
Sbjct: 65  ---WSPAEELNYTVPGPGPAGEASPRQCRRY-EVDWNQSTFDCVDPLASLDTNRSRLPLG 120

Query: 115 PCVDGWVYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKI 174
           PC DGWVY+     S+IVTE++LVC +  +  + QS    G  +G +  G+++DR GRK+
Sbjct: 121 PCRDGWVYETPG--SSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKL 178

Query: 175 ICKLCFLQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTI 234
                 L  A +    A +PT+    I R + G  +       +IL  E+   R R    
Sbjct: 179 CLLTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVG 238

Query: 235 MVLLCSYSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDE 294
           +    +Y+VG ++L G+A+A+  W  LQ TV+ P     L  W + ES RWLI  N+  E
Sbjct: 239 IFYQVAYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNAE 298

Query: 295 GLKELRRVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRVFGLC 354
            ++ ++ +A  NGK     +L   L R  +++E    ++  S   L R P++R     L 
Sbjct: 299 AMRIIKHIAKKNGK-----SLPASLQRLRLEEETGK-KLNPSFLDLVRTPQIRKHTMILM 352

Query: 355 FVRFAITVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQILFTF 414
           +  F  +V + GLI+++   G N+ L       V F A  + +LT++ +GRR        
Sbjct: 353 YNWFTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNM 412

Query: 415 PVGLFILVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAGINAV 474
             G   L + F+P ++Q L+++++ LG   ++ A     + + EL PT +R+    I + 
Sbjct: 413 VAGAACLASVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSS 472

Query: 475 SGRTGAALAPLLM-TLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDVENE 533
               G  + P L+  L      LP + +GV  ++A  ++LLLPET+   LP TI++ EN 
Sbjct: 473 MCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENM 532

Query: 534 KDSRNIKQEDTCMKV 548
           +  R  K++   ++V
Sbjct: 533 QRPRKNKEKMIYLQV 547


>gi|169202895 PREDICTED: similar to solute carrier family 22, member
           24 [Homo sapiens]
          Length = 139

 Score =  199 bits (505), Expect = 7e-51
 Identities = 94/134 (70%), Positives = 111/134 (82%)

Query: 1   MGFDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVS 60
           MGFD+LLDQVGG+GRFQI  + F  I+ I+ +P+++LENF AF P H  WV +LDNDTVS
Sbjct: 1   MGFDMLLDQVGGLGRFQIFHLIFLTISIIIHYPHLLLENFIAFIPGHHYWVHILDNDTVS 60

Query: 61  DNDTGTLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDGW 120
           DNDTGTLS+  LLRISIPLDSNLRP+KC+ FIHPQW LLHLN TF N +EP+TEPCV GW
Sbjct: 61  DNDTGTLSQVALLRISIPLDSNLRPEKCRCFIHPQWHLLHLNVTFSNMSEPNTEPCVGGW 120

Query: 121 VYDRSSFLSTIVTE 134
           VY +SSFL TIVT+
Sbjct: 121 VYHQSSFLFTIVTD 134


>gi|239750073 PREDICTED: similar to solute carrier family 22, member
           24 [Homo sapiens]
          Length = 139

 Score =  199 bits (505), Expect = 7e-51
 Identities = 94/134 (70%), Positives = 111/134 (82%)

Query: 1   MGFDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVS 60
           MGFD+LLDQVGG+GRFQI  + F  I+ I+ +P+++LENF AF P H  WV +LDNDTVS
Sbjct: 1   MGFDMLLDQVGGLGRFQIFHLIFLTISIIIHYPHLLLENFIAFIPGHHYWVHILDNDTVS 60

Query: 61  DNDTGTLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDGW 120
           DNDTGTLS+  LLRISIPLDSNLRP+KC+ FIHPQW LLHLN TF N +EP+TEPCV GW
Sbjct: 61  DNDTGTLSQVALLRISIPLDSNLRPEKCRCFIHPQWHLLHLNVTFSNMSEPNTEPCVGGW 120

Query: 121 VYDRSSFLSTIVTE 134
           VY +SSFL TIVT+
Sbjct: 121 VYHQSSFLFTIVTD 134


>gi|239744382 PREDICTED: hypothetical protein XP_002343132 [Homo
           sapiens]
          Length = 139

 Score =  199 bits (505), Expect = 7e-51
 Identities = 94/134 (70%), Positives = 111/134 (82%)

Query: 1   MGFDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVS 60
           MGFD+LLDQVGG+GRFQI  + F  I+ I+ +P+++LENF AF P H  WV +LDNDTVS
Sbjct: 1   MGFDMLLDQVGGLGRFQIFHLIFLTISIIIHYPHLLLENFIAFIPGHHYWVHILDNDTVS 60

Query: 61  DNDTGTLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDGW 120
           DNDTGTLS+  LLRISIPLDSNLRP+KC+ FIHPQW LLHLN TF N +EP+TEPCV GW
Sbjct: 61  DNDTGTLSQVALLRISIPLDSNLRPEKCRCFIHPQWHLLHLNVTFSNMSEPNTEPCVGGW 120

Query: 121 VYDRSSFLSTIVTE 134
           VY +SSFL TIVT+
Sbjct: 121 VYHQSSFLFTIVTD 134


>gi|4507005 solute carrier family 22 member 5 [Homo sapiens]
          Length = 557

 Score =  194 bits (494), Expect = 1e-49
 Identities = 158/553 (28%), Positives = 250/553 (45%), Gaps = 37/553 (6%)

Query: 3   FDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAF-------TPSHRCWVPLLD 55
           +D +   +G  G FQ   + FF     LL  +I+   FT         TP HRC VP   
Sbjct: 4   YDEVTAFLGEWGPFQ--RLIFF-----LLSASIIPNGFTGLSSVFLIATPEHRCRVP--- 53

Query: 56  NDTVSDNDTGTLSKDDLLRISIPL---DSNLRPQKCQRF---IHPQWQLLHLN-GTFPNT 108
                  D   LS       ++PL   D    P  C+R+       +  L L  G   + 
Sbjct: 54  -------DAANLSSA-WRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDL 105

Query: 109 NEPDTEPCVDGWVYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSD 168
            + + E C+DGW + +  +LSTIVTEW+LVCE      +  SLF  G LLG  I G LSD
Sbjct: 106 GQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSD 165

Query: 169 RVGRKIICKLCFLQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPR 228
           R GRK +  +        +    F+  F ++ +L  L G   ++     F+L  E     
Sbjct: 166 RFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKS 225

Query: 229 SRSMTIMVLLCS-YSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLI 287
            R +   + +C  Y+ G M+L   A+ I+DW +L + ++ P ++     W + ES RWLI
Sbjct: 226 VRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLI 285

Query: 288 INNQLDEGLKELRRVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLR 347
              + +E    +R+ A  NG            ++    K+  +     +I  L R   +R
Sbjct: 286 SQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQS----HNILDLLRTWNIR 341

Query: 348 MRVFGLCFVRFAITVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRI 407
           M       +   I+V ++GL L+  +L  ++ +   L   V   A  ++ L L ++ RR 
Sbjct: 342 MVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRY 401

Query: 408 SQILFTFPVGLFILVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRST 467
           S     F  G  +L    +P ++  L  VL  +G   V+AA +   V+  EL PT++R+ 
Sbjct: 402 SMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNM 461

Query: 468 VAGINAVSGRTGAALAPLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTI 527
             G+++ + R G+ L+P  + L AY   LP+I  G   IL   + L LPE+   PLP+TI
Sbjct: 462 GVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTI 521

Query: 528 QDVENEKDSRNIK 540
             +   K  ++ K
Sbjct: 522 DQMLRVKGMKHRK 534


>gi|31542327 solute carrier family 22, member 16 [Homo sapiens]
          Length = 577

 Score =  191 bits (486), Expect = 1e-48
 Identities = 149/553 (26%), Positives = 249/553 (45%), Gaps = 21/553 (3%)

Query: 3   FDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVSDN 62
           F+ + D VG  GRFQ  L       NI    + +   F   TP H C  P   +  V  N
Sbjct: 6   FEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHN 65

Query: 63  -------DTGTL---SKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPD 112
                  DTG L    + D + + +         +C R        L     +  T    
Sbjct: 66  HSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLG----YEYTGSKK 121

Query: 113 TEPCVDGWVYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGR 172
             PCVDG++YD++++ ST VT+W+LVC+ + L  ++Q LFM G LLG + +G+ SDR+GR
Sbjct: 122 EFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGR 181

Query: 173 KIICKLCFLQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSM 232
           +++       + +    AAFA  +  +   RF         L   F+  +E+   +SR+ 
Sbjct: 182 RVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTW 241

Query: 233 TIMVLLCSYSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQL 292
             + L   ++VG +L+    + ++ W + Q+ +ST  +   L  W + E+  WL+   + 
Sbjct: 242 ASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRY 301

Query: 293 DEGLKELRRVAHINGKKNTE--ETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRV 350
           +E  K +  +A  N   + +  E L+ +L         +    K ++  LF    +  R 
Sbjct: 302 EEAQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEVQ--KHNLSYLFYNWSITKRT 359

Query: 351 FGLCFVRFAITVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQI 410
             +  + F  ++ FY   LN  +LG N  L   L G V   A     + ++ +GRR    
Sbjct: 360 LTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLA 419

Query: 411 LFTFPVGLFILVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAG 470
              F   L   V   +PQ+  IL VV A +G  ++ AA     ++  EL PTI+RS   G
Sbjct: 420 YSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVG 479

Query: 471 INAVSGRTGAALAPLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQD- 529
             ++  R  + LAP  + L +    +P +  G   +L+  + L LPET    L  T ++ 
Sbjct: 480 SGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEEA 539

Query: 530 --VENEKDSRNIK 540
             +E+E +S++ K
Sbjct: 540 AKLESENESKSSK 552


>gi|24497490 solute carrier family 22 member 4 [Homo sapiens]
          Length = 551

 Score =  177 bits (448), Expect = 3e-44
 Identities = 150/560 (26%), Positives = 251/560 (44%), Gaps = 33/560 (5%)

Query: 3   FDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVSDN 62
           +D ++  +G  G FQ  +      + I    N +   F A TP HRC VP          
Sbjct: 4   YDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVP---------- 53

Query: 63  DTGTLSKDDLLRISIPL---DSNLRPQKCQRF---IHPQWQLLHLN-GTFPNTNEPDTEP 115
           D   LS       S+PL   D    P  C R+       +  L L  G   +  + + E 
Sbjct: 54  DAANLSSA-WRNNSVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQES 112

Query: 116 CVDGWVYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKII 175
           C+DGW + +  +LST+VTEW+LVCE      +  SLF  G LLG  + G LSDR GRK  
Sbjct: 113 CLDGWEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRK-- 170

Query: 176 CKLCFLQLAISNTCA---AFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSM 232
             + F  +A+    +    F+ ++ ++ +L  + G   ++     FIL  E      R +
Sbjct: 171 -NVLFATMAVQTGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRII 229

Query: 233 TIMVLLCSY-SVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQ 291
              + +C++ +VG MLL   A+ I+DW +L L ++ P ++     W + ES RWLI   +
Sbjct: 230 FSTLGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRR 289

Query: 292 LDEGLKELRRVAHINGKKNTEETLTTELVRSTMKKELDAVRI-KTSIFSLFRAPKLRMRV 350
             E    +++ A +N        +    V     +EL+ ++  K  I  LFR   + +  
Sbjct: 290 FREAEDIIQKAAKMNN-------IAVPAVIFDSVEELNPLKQQKAFILDLFRTRNIAIMT 342

Query: 351 FGLCFVRFAITVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQI 410
                +    +V ++ L L+  +L  +  L   L   +   A   + L L  + RR    
Sbjct: 343 IMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIA 402

Query: 411 LFTFPVGLFILVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAG 470
              F  G  +L    +P +   L + L  LG   +++A +   V   EL PT++R+   G
Sbjct: 403 AVLFWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVG 462

Query: 471 INAVSGRTGAALAPLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDV 530
           + + + R G+ +AP  + L AY+  LP+I  G   +L   + L  PE+  + LP T++ +
Sbjct: 463 VTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQM 522

Query: 531 ENEKDSRNIKQEDTCMKVTQ 550
           +  K  R+ K+    M+  +
Sbjct: 523 QKVKWFRSGKKTRDSMETEE 542


>gi|23510410 solute carrier family 22 member 1 isoform b [Homo
           sapiens]
          Length = 506

 Score =  176 bits (446), Expect = 5e-44
 Identities = 138/489 (28%), Positives = 213/489 (43%), Gaps = 31/489 (6%)

Query: 4   DVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVSDND 63
           D +L+QVG  G FQ       C+ +    P  V   F  FTP H C  P         + 
Sbjct: 5   DDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSP----GVAELSQ 60

Query: 64  TGTLSKDDLLRISIPLDSNLRPQ------KCQRFIHPQWQLLHLNGTFP------NTNEP 111
               S  + L  ++P    L P       +C+R+    W    L+   P      N +  
Sbjct: 61  RCGWSPAEELNYTVP---GLGPAGEAFLGQCRRY-EVDWNQSALSCVDPLASLATNRSHL 116

Query: 112 DTEPCVDGWVYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVG 171
              PC DGWVYD     S+IVTE++LVC       + QS   AG L G L  G+ +DR G
Sbjct: 117 PLGPCQDGWVYDTPG--SSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFG 174

Query: 172 RKIICKLCFLQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRS 231
           RK+      L  A+S    AF+P ++   + R L G  +       + L  E+    SR 
Sbjct: 175 RKLCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRR 234

Query: 232 MTIMVLLCSYSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQ 291
              ++   +++VG + L GLA+A+  W  LQL VS P  +  L  W + ES RWL+   +
Sbjct: 235 TVAIMYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKR 294

Query: 292 LDEGLKELRRVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRVF 351
             E +K +  +A  NGK    +     L     +K      +  S   LFR P+LR R F
Sbjct: 295 NTEAIKIMDHIAQKNGKLPPADLKMLSLEEDVTEK------LSPSFADLFRTPRLRKRTF 348

Query: 352 GLCFVRFAITVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQIL 411
            L ++ F  +V + GLIL++     N+ L  +    V      ++L+T++ +GR     +
Sbjct: 349 ILMYLWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAM 408

Query: 412 FTFPVGLFILVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRS---TV 468
                G   LV  F+  ++  L +++  +G   ++ A     + + EL PT +       
Sbjct: 409 SNLLAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVSGVGPAC 468

Query: 469 AGINAVSGR 477
            G +A S R
Sbjct: 469 RGSDATSSR 477


>gi|157426885 organic cation transporter like 4 [Homo sapiens]
          Length = 594

 Score =  172 bits (436), Expect = 7e-43
 Identities = 147/562 (26%), Positives = 259/562 (46%), Gaps = 44/562 (7%)

Query: 3   FDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRC---WVPLLDNDTV 59
           F  LLD VG  G FQ  L+A   I +I+    +  ++F        C   W+  +     
Sbjct: 52  FANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYCNTSWILAVGPH-- 109

Query: 60  SDNDTGTLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDG 119
                  LSK + L ++IP   N     C  ++   W L  +     N    DT+ C DG
Sbjct: 110 -------LSKAEQLNLTIPQAPNGSFLTCFMYLPVPWNLDSIIQFGLN----DTDTCQDG 158

Query: 120 WVYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLC 179
           W+Y  +   S ++ E+DLVC  ++ K   Q +FMAG  +G LI+  ++D++GR     L 
Sbjct: 159 WIYPDAKKRS-LINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLS 217

Query: 180 FLQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLC 239
            L L I     AF  +F +Y   RF    S +    ++  L+ EW +   R+  I++  C
Sbjct: 218 LLGLIIFGFGTAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHC 277

Query: 240 SYSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKEL 299
            ++VG +LL G+A+++  W +L L     +I      W + ES RWL++  ++ E  + L
Sbjct: 278 FFAVGAVLLTGIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVL 337

Query: 300 RRVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRVFGLCFVRFA 359
              A +N KK     L  EL     K        + S+    +  +L      +  V F 
Sbjct: 338 CYAASVN-KKTIPSNLLDELQLPRKKV------TRASVLDFCKNRQLCKVTLVMSCVWFT 390

Query: 360 ITVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQILFTFPVGLF 419
           ++  ++ L L ++ LG +V    ++   +   AR   +  L  +GR+ S  +      ++
Sbjct: 391 VSYTYFTLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIW 450

Query: 420 ILVNTFLPQ---------------EMQILRVVLATLGIGSVSAASNSASVHHNELVPTIL 464
            L+  FLP+               E++ + +++  L   S++A      ++  EL+PT+L
Sbjct: 451 CLLLLFLPEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVL 510

Query: 465 RSTVAGINAVSGRTGAALAPLLMTLMAYSPH-LPWISYGVFPILAVPVILLLPETRDLPL 523
           R+T  G+ +++   GA L+   +T+++ +P  LP     V  I+A  +  LLPETRD PL
Sbjct: 511 RATGLGLVSLASVAGAILS---LTIISQTPSLLPIFLCCVLAIVAFSLSSLLPETRDQPL 567

Query: 524 PNTIQDVENEKDS-RNIKQEDT 544
             ++      ++  +++K ++T
Sbjct: 568 SESLNHSSQIRNKVKDMKTKET 589


>gi|166197673 solute carrier family 22, member 15 [Homo sapiens]
          Length = 547

 Score =  144 bits (362), Expect = 3e-34
 Identities = 122/421 (28%), Positives = 190/421 (45%), Gaps = 28/421 (6%)

Query: 125 SSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCFLQLA 184
           SS  ++I +EW L+       S   S F +G  +G + +G LSDR GRK +    F    
Sbjct: 91  SSSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDI 150

Query: 185 ISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLE------WTLPRSRSMTIMVLL 238
           +      F+P++  + + RFL G     +    F+L  E      W L  S    I  L 
Sbjct: 151 LFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGS----IGGLF 206

Query: 239 CSYSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKE 298
            +  + Q  L  L + I+ W  L + V+    V+FL S  + ES RWL    +L E  + 
Sbjct: 207 FAVGIAQYAL--LGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEA 264

Query: 299 LRRVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRVFGLCFVRF 358
           L  +A  N K     +LT    RS         R   S   LFR   L      L F+ F
Sbjct: 265 LYLIAKRNRKLKCTFSLTHPANRSC--------RETGSFLDLFRYRVLLGHTLILMFIWF 316

Query: 359 AITVPFYGLILNLQHLGSNVSLFQILCGAVTFTAR--CVSLLTLNHMGRRISQILFTFPV 416
             ++ +YGL L+   LG ++     L G +   +   C+ L+     GR+ +   F    
Sbjct: 317 VCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLG 376

Query: 417 GLFILVNTFLPQEMQ--ILRVV----LATLGIGSVSAASNSASVHHNELVPTILRSTVAG 470
           GL  L+  FLP++    +  VV    L+ LG  ++SAA N   ++ +EL PT++R+   G
Sbjct: 377 GLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLG 436

Query: 471 INAVSGRTGAALAPLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDV 530
             ++  R G  +AP + +L      LP+I +G   + +  + LLLPET + PL  T  D+
Sbjct: 437 TCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDL 496

Query: 531 E 531
           +
Sbjct: 497 Q 497


>gi|63999576 solute carrier family 22, member 17 isoform b [Homo
           sapiens]
          Length = 520

 Score =  113 bits (283), Expect = 4e-25
 Identities = 119/437 (27%), Positives = 181/437 (41%), Gaps = 26/437 (5%)

Query: 111 PDTEPCVDGWVYDRSSFLST-IVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDR 169
           PD   C+  W Y+    L+T  + +WDLVC+      + Q LF+ G   G L  G+ +DR
Sbjct: 65  PDFNHCLKDWDYNGLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADR 124

Query: 170 VGRKIICKLCFLQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRS 229
            GR+ I  L    +       A A +      LRFL GF    +    +++ LE   P  
Sbjct: 125 FGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQ 184

Query: 230 RSMTIMVLLCSYSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWK--MVESARWLI 287
           R    +        G  L  GLA   +DW  LQ  ++ P I+     W    +ESARWLI
Sbjct: 185 RLRVALAGELVGVGGHFLFLGLALVSKDWRFLQRMITAPCILFLFYGWPGLFLESARWLI 244

Query: 288 INNQLDEGLKELRRVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSL-----FR 342
           +  Q++E    LR +A  N  +   + L  E   +    E       TS FS      +R
Sbjct: 245 VKRQIEEAQSVLRILAERN--RPHGQMLGEEAQEALQDLENTCPLPATSSFSFASLLNYR 302

Query: 343 APKLRMRVFGLC-FVRFAIT---VPFYGLILNLQHLGSNVSLFQI--LCGAVTFTARCVS 396
                + + G   F+  AI     P  G        G + S F +  L  + T    CV 
Sbjct: 303 NIWKNLLILGFTNFIAHAIRHCYQPVGG--------GGSPSDFYLCSLLASGTAALACVF 354

Query: 397 L-LTLNHMGRRISQILFTFPVGLFILVNTFLPQEMQILRV-VLATLGIGSVSAASNSASV 454
           L +T++  GRR   +L     G+  LV   L   +    +   + LG+ S  AA+  +++
Sbjct: 355 LGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDYLNEAAITTFSVLGLFSSQAAAILSTL 414

Query: 455 HHNELVPTILRSTVAGINAVSGRTGAALAPLLMTLMAYSPHLPWISYGVFPILAVPVILL 514
              E++PT +R    G+    G  G    P     M +   L  +      +L +  I+L
Sbjct: 415 LAAEVIPTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIML 474

Query: 515 LPETRDLPLPNTIQDVE 531
           LPET+   LP  ++D E
Sbjct: 475 LPETKRKLLPEVLRDGE 491


>gi|170650643 solute carrier family 22, member 23 isoform a [Homo
           sapiens]
          Length = 686

 Score =  108 bits (271), Expect = 1e-23
 Identities = 105/446 (23%), Positives = 175/446 (39%), Gaps = 46/446 (10%)

Query: 120 WVYD-RSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKL 178
           W Y  R+  +  +V++WDLVC++     + +   + G + G LI G ++D VGR+ +   
Sbjct: 203 WDYGIRAGLVQNVVSKWDLVCDNAWKVHIAKFSLLVGLIFGYLITGCIADWVGRRPVLLF 262

Query: 179 CFLQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLL 238
             + + I     A +    ++  LRF  GF    I+   + L +E   P  R M  MV  
Sbjct: 263 SIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVAS 322

Query: 239 CSYSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKE 298
                GQ L+ GLA   +DW +LQ  +  P +++ L      ES RWL+   Q +     
Sbjct: 323 FVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAK-- 380

Query: 299 LRRVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRVFGLC---- 354
            R + H   K         + V   ++KEL     K  I  +     L   +  LC    
Sbjct: 381 -RLILHFTQKNRMNPEGDIKGVIPELEKELSRRPKKVCIVKVVGTRNLWKNIVVLCVNSL 439

Query: 355 --------FVR----FAITVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNH 402
                   F R      + VP         +  ++++L   L       A CV    +  
Sbjct: 440 TGYGIHHCFARSMMGHEVKVPLLENFYADYYTTASIALVSCL-------AMCV---VVRF 489

Query: 403 MGRRISQILFTF--------PVGLFILVNTFLPQE--------MQILRVVLATLGIGSVS 446
           +GRR   +LF           +GL  L+  +                 +  + +G+ +  
Sbjct: 490 LGRRGGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASH 549

Query: 447 AASNSASVHHNELVPTILRSTVAGINAVSGRTGAALAPLLMTLMAYSPHLPWISYGVFPI 506
           A  + +     E+ PT++R    G+   S   G   AP++         L  I +    +
Sbjct: 550 AVGSLSVFFCAEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHHIIFACCTL 609

Query: 507 LAVPVILLLPETRDLPLPNTIQDVEN 532
           + +  ILLLPE+RD  LP  I + E+
Sbjct: 610 ICIICILLLPESRDQNLPENISNGEH 635


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.327    0.140    0.428 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,971,952
Number of Sequences: 37866
Number of extensions: 802000
Number of successful extensions: 2487
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 44
Number of HSP's successfully gapped in prelim test: 26
Number of HSP's that attempted gapping in prelim test: 2337
Number of HSP's gapped (non-prelim): 88
length of query: 551
length of database: 18,247,518
effective HSP length: 107
effective length of query: 444
effective length of database: 14,195,856
effective search space: 6302960064
effective search space used: 6302960064
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.