Guide to the Human Genome
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Search of human proteins with 210032390

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|210032390 SEC13 protein isoform 2 [Homo sapiens]
         (308 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|210032390 SEC13 protein isoform 2 [Homo sapiens]                   659   0.0  
gi|34335134 SEC13 protein isoform 1 [Homo sapiens]                    659   0.0  
gi|61743971 sec13-like protein isoform 1 [Homo sapiens]               151   8e-37
gi|61743969 sec13-like protein isoform 2 [Homo sapiens]               151   8e-37
gi|4757988 WD repeat domain 39 [Homo sapiens]                         103   1e-22
gi|4557741 platelet-activating factor acetylhydrolase, isoform I...    68   1e-11
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]    64   1e-10
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H...    64   2e-10
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho...    64   2e-10
gi|19913367 transducin beta-like 1Y [Homo sapiens]                     63   4e-10
gi|19913365 transducin beta-like 1Y [Homo sapiens]                     63   4e-10
gi|15150805 transducin beta-like 1Y [Homo sapiens]                     63   4e-10
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H...    60   2e-09
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho...    60   2e-09
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]     59   4e-09
gi|19913369 transducin beta-like 3 [Homo sapiens]                      58   9e-09
gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]             58   1e-08
gi|23199987 WD repeat domain 5B [Homo sapiens]                         55   8e-08
gi|14150171 THO complex 3 [Homo sapiens]                               54   2e-07
gi|237820620 glutamate-rich WD repeat containing 1 [Homo sapiens]      53   4e-07
gi|223029510 echinoderm microtubule associated protein like 4 is...    53   4e-07
gi|19923497 echinoderm microtubule associated protein like 4 iso...    53   4e-07
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s...    53   4e-07
gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]               53   4e-07
gi|89026256 PREDICTED: similar to actin related protein 2/3 comp...    52   5e-07
gi|5031601 actin related protein 2/3 complex subunit 1B [Homo sa...    52   5e-07
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]          52   7e-07
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]          52   7e-07
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]          52   7e-07
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]            52   7e-07

>gi|210032390 SEC13 protein isoform 2 [Homo sapiens]
          Length = 308

 Score =  659 bits (1699), Expect = 0.0
 Identities = 308/308 (100%), Positives = 308/308 (100%)

Query: 1   MIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNIL 60
           MIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNIL
Sbjct: 1   MIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNIL 60

Query: 61  ASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY 120
           ASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY
Sbjct: 61  ASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY 120

Query: 121 TGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLW 180
           TGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLW
Sbjct: 121 TGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLW 180

Query: 181 KEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWS 240
           KEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWS
Sbjct: 181 KEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWS 240

Query: 241 PKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVSASV 300
           PKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVSASV
Sbjct: 241 PKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVSASV 300

Query: 301 TEGQQNEQ 308
           TEGQQNEQ
Sbjct: 301 TEGQQNEQ 308


>gi|34335134 SEC13 protein isoform 1 [Homo sapiens]
          Length = 322

 Score =  659 bits (1699), Expect = 0.0
 Identities = 308/308 (100%), Positives = 308/308 (100%)

Query: 1   MIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNIL 60
           MIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNIL
Sbjct: 15  MIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNIL 74

Query: 61  ASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY 120
           ASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY
Sbjct: 75  ASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY 134

Query: 121 TGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLW 180
           TGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLW
Sbjct: 135 TGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLW 194

Query: 181 KEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWS 240
           KEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWS
Sbjct: 195 KEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWS 254

Query: 241 PKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVSASV 300
           PKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVSASV
Sbjct: 255 PKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVSASV 314

Query: 301 TEGQQNEQ 308
           TEGQQNEQ
Sbjct: 315 TEGQQNEQ 322


>gi|61743971 sec13-like protein isoform 1 [Homo sapiens]
          Length = 421

 Score =  151 bits (381), Expect = 8e-37
 Identities = 103/338 (30%), Positives = 156/338 (46%), Gaps = 47/338 (13%)

Query: 1   MIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQI-LIADLRGHEGPVWQVAWAHPMYGNI 59
           +IHD   D++G R+ATCSSD+SVK++D    G     A  + H G VW+V WAHP +G +
Sbjct: 14  LIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEFGQV 73

Query: 60  LASCSYDRKVIIWREENGT----------WEKSHEHAGHDSSVNSVCWAPHDYGLILACG 109
           LASCS+DR   +W E  G           W K        +SV  V +AP   GL+LA  
Sbjct: 74  LASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATC 133

Query: 110 SSDGAISLL---TYTGEGQWEVKKINNAHTIGCNAVSW--------APAVVPGSLIDHPS 158
           S+DG + +          QW ++    +  + C+ +SW        +P +  GS    P+
Sbjct: 134 SADGIVRIYEAPDVMNLSQWSLQH-EISCKLSCSCISWNPSSSRAHSPMIAVGSDDSSPN 192

Query: 159 GQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIA 218
                 I  +              E   ++ + + L   +D V D+A+AP++G     +A
Sbjct: 193 AMAKVQIFEY-------------NENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILA 239

Query: 219 SCSQDGRVFIW------TCDDASSNTWSPKLLHKF---NDVVWHVSWSITANILAVSGGD 269
             ++D R+F                 +   ++ +F   N  VW VSW+IT  +LA SG D
Sbjct: 240 IATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDD 299

Query: 270 NKVTLWKESVDGQWVCISDVNKGQGS-VSASVTEGQQN 306
             V LWK +    W C + + KG GS V+ S  +G  N
Sbjct: 300 GCVRLWKANYMDNWKC-TGILKGNGSPVNGSSQQGTSN 336



 Score = 31.6 bits (70), Expect = 0.93
 Identities = 14/48 (29%), Positives = 21/48 (43%)

Query: 249 DVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSV 296
           D++  VS+      +A    D  V +W +S  G W C +      GSV
Sbjct: 13  DLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSV 60


>gi|61743969 sec13-like protein isoform 2 [Homo sapiens]
          Length = 360

 Score =  151 bits (381), Expect = 8e-37
 Identities = 103/338 (30%), Positives = 156/338 (46%), Gaps = 47/338 (13%)

Query: 1   MIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQI-LIADLRGHEGPVWQVAWAHPMYGNI 59
           +IHD   D++G R+ATCSSD+SVK++D    G     A  + H G VW+V WAHP +G +
Sbjct: 14  LIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEFGQV 73

Query: 60  LASCSYDRKVIIWREENGT----------WEKSHEHAGHDSSVNSVCWAPHDYGLILACG 109
           LASCS+DR   +W E  G           W K        +SV  V +AP   GL+LA  
Sbjct: 74  LASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATC 133

Query: 110 SSDGAISLL---TYTGEGQWEVKKINNAHTIGCNAVSW--------APAVVPGSLIDHPS 158
           S+DG + +          QW ++    +  + C+ +SW        +P +  GS    P+
Sbjct: 134 SADGIVRIYEAPDVMNLSQWSLQH-EISCKLSCSCISWNPSSSRAHSPMIAVGSDDSSPN 192

Query: 159 GQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIA 218
                 I  +              E   ++ + + L   +D V D+A+AP++G     +A
Sbjct: 193 AMAKVQIFEY-------------NENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILA 239

Query: 219 SCSQDGRVFIW------TCDDASSNTWSPKLLHKF---NDVVWHVSWSITANILAVSGGD 269
             ++D R+F                 +   ++ +F   N  VW VSW+IT  +LA SG D
Sbjct: 240 IATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDD 299

Query: 270 NKVTLWKESVDGQWVCISDVNKGQGS-VSASVTEGQQN 306
             V LWK +    W C + + KG GS V+ S  +G  N
Sbjct: 300 GCVRLWKANYMDNWKC-TGILKGNGSPVNGSSQQGTSN 336



 Score = 31.6 bits (70), Expect = 0.93
 Identities = 14/48 (29%), Positives = 21/48 (43%)

Query: 249 DVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSV 296
           D++  VS+      +A    D  V +W +S  G W C +      GSV
Sbjct: 13  DLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSV 60


>gi|4757988 WD repeat domain 39 [Homo sapiens]
          Length = 339

 Score =  103 bits (258), Expect = 1e-22
 Identities = 83/280 (29%), Positives = 126/280 (45%), Gaps = 39/280 (13%)

Query: 11  GTRLATCSSDRSVKIFDVRNGGQILIADL-RGHEGPVWQVAWAHPMYGNILASCSYDRKV 69
           GT LA+C  DR ++I+       I  + L  GH+  V +VAW+    GN LAS S+D   
Sbjct: 28  GTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSP--CGNYLASASFDATT 85

Query: 70  IIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVK 129
            IW++    +E      GH++ V SV WAP   G +LA  S D ++ +     E ++E  
Sbjct: 86  CIWKKNQDDFECVTTLEGHENEVKSVAWAPS--GNLLATCSRDKSVWVWEVDEEDEYECV 143

Query: 130 KINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWK 189
            + N+HT     V W           HPS +        AS   D+ +KL++EEED  W 
Sbjct: 144 SVLNSHTQDVKHVVW-----------HPSQE------LLASASYDDTVKLYREEED-DWV 185

Query: 190 EEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIW-----------TCDDASSNT 238
               LE H   V  +A+ PS       +ASCS D  V IW            C  +  + 
Sbjct: 186 CCATLEGHESTVWSLAFDPS----GQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSW 241

Query: 239 WSPKLLHKFND-VVWHVSWSITANILAVSGGDNKVTLWKE 277
                L  F+   ++ ++W      LA + GD+ + +++E
Sbjct: 242 KCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQE 281



 Score = 75.1 bits (183), Expect = 7e-14
 Identities = 66/251 (26%), Positives = 113/251 (45%), Gaps = 32/251 (12%)

Query: 34  ILIADLRGH-EGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWE-KSHEHAGHDSS 91
           +L+  +  H +   W +AW +P  G +LASC  DR++ IW  E  +W  KS    GH  +
Sbjct: 6   VLLGRVPAHPDSRCWFLAW-NPA-GTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRT 63

Query: 92  VNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPG 151
           V  V W+P   G  LA  S D A + +    +  +E       H     +V+WAP+   G
Sbjct: 64  VRKVAWSP--CGNYLASASFD-ATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPS---G 117

Query: 152 SLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIG 211
           +L+              A+   D  + +W+ +E+ +++    L +H+  V+ V W PS  
Sbjct: 118 NLL--------------ATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQE 163

Query: 212 LPTSTIASCSQDGRVFIWTCDDASSNTW-SPKLLHKFNDVVWHVSWSITANILAVSGGDN 270
           L    +AS S D  V ++  ++   + W     L      VW +++  +   LA    D 
Sbjct: 164 L----LASASYDDTVKLYREEE---DDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDR 216

Query: 271 KVTLWKESVDG 281
            V +W++ + G
Sbjct: 217 TVRIWRQYLPG 227



 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 69/237 (29%), Positives = 99/237 (41%), Gaps = 40/237 (16%)

Query: 11  GTRLATCSSDRSVKIFDVRNGGQI-LIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKV 69
           G  LATCS D+SV +++V    +   ++ L  H   V  V W HP    +LAS SYD  V
Sbjct: 117 GNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVW-HPSQ-ELLASASYDDTV 174

Query: 70  IIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVK 129
            ++REE   W       GH+S+V S+ + P   G  LA  S D  + +        W   
Sbjct: 175 KLYREEEDDWVCCATLEGHESTVWSLAFDPS--GQRLASCSDDRTVRI--------WRQY 224

Query: 130 KINNAHTIGCNAV--SWAPAVVPGSLIDHPSGQKPNYIKRFA--------SGGC-DNLIK 178
              N   + C+    SW         I   SG     I   A        +  C D+ I+
Sbjct: 225 LPGNEQGVACSGSDPSW-------KCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIR 277

Query: 179 LWKEEEDGQWKEE------QKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIW 229
           +++E+ +   ++          +AHS  V  VAW P        +ASCS DG V  W
Sbjct: 278 VFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPK---EPGLLASCSDDGEVAFW 331



 Score = 52.8 bits (125), Expect = 4e-07
 Identities = 38/124 (30%), Positives = 56/124 (45%), Gaps = 10/124 (8%)

Query: 169 ASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFI 228
           AS G D  I++W  E D    +    E H   VR VAW+P      + +AS S D    I
Sbjct: 32  ASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPC----GNYLASASFDATTCI 87

Query: 229 W--TCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCI 286
           W    DD    T     L    + V  V+W+ + N+LA    D  V +W+   + ++ C+
Sbjct: 88  WKKNQDDFECVT----TLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECV 143

Query: 287 SDVN 290
           S +N
Sbjct: 144 SVLN 147



 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 37/133 (27%), Positives = 57/133 (42%), Gaps = 22/133 (16%)

Query: 8   DYYGTRLATCSSDRSVKIFDVRNGGQI-------------LIADLRG-HEGPVWQVAWAH 53
           D  G RLA+CS DR+V+I+     G                I  L G H   ++ +AW  
Sbjct: 203 DPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQ 262

Query: 54  PMYGNILASCSYDRKVIIWREENGTWEK------SHEHAGHDSSVNSVCWAPHDYGLILA 107
            + G +  +C  D   +   + N   ++      +H H  H   VN V W P + GL+ +
Sbjct: 263 -LTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLAS 321

Query: 108 CGSSDGAISLLTY 120
           C S DG ++   Y
Sbjct: 322 C-SDDGEVAFWKY 333



 Score = 35.8 bits (81), Expect = 0.049
 Identities = 13/41 (31%), Positives = 24/41 (58%), Gaps = 1/41 (2%)

Query: 252 WHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKG 292
           W ++W+    +LA  GGD ++ +W    D  W+C S +++G
Sbjct: 20  WFLAWNPAGTLLASCGGDRRIRIWGTEGD-SWICKSVLSEG 59


>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
           alpha subunit [Homo sapiens]
          Length = 410

 Score = 67.8 bits (164), Expect = 1e-11
 Identities = 71/279 (25%), Positives = 119/279 (42%), Gaps = 27/279 (9%)

Query: 2   IHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILA 61
           + D   D+ G  LA+CS+D ++K++D +  G   I  + GH+  V  VA      G+ + 
Sbjct: 153 VQDISFDHSGKLLASCSADMTIKLWDFQ--GFECIRTMHGHDHNVSSVAIM--PNGDHIV 208

Query: 62  SCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISL-LTY 120
           S S D+ + +W  + G   K+    GH   V  V   P+  G ++A  S+D  + + +  
Sbjct: 209 SASRDKTIKMWEVQTGYCVKT--FTGHREWVRMV--RPNQDGTLIASCSNDQTVRVWVVA 264

Query: 121 TGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKR---FASGGCDNLI 177
           T E + E+++  + H + C  +SWAP     S+ +    +     K      SG  D  I
Sbjct: 265 TKECKAELRE--HEHVVEC--ISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTI 320

Query: 178 KLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSN 237
           K+W +   G       L  H +WVR V +          I SC+ D  + +W       N
Sbjct: 321 KMW-DVSTGMCL--MTLVGHDNWVRGVLFHSG----GKFILSCADDKTLRVWD----YKN 369

Query: 238 TWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 276
               K L+     V  + +  TA  +     D  V +W+
Sbjct: 370 KRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408



 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 60/228 (26%), Positives = 98/228 (42%), Gaps = 37/228 (16%)

Query: 39  LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWA 98
           L GH  PV +V + HP++ +++ S S D  + +W  E G +E++ +  GH  SV  + + 
Sbjct: 104 LSGHRSPVTRVIF-HPVF-SVMVSASEDATIKVWDYETGDFERTLK--GHTDSVQDISF- 158

Query: 99  PHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPS 158
               G +LA  S+D  I L  + G   +E  +  + H    ++V    A++P    DH  
Sbjct: 159 -DHSGKLLASCSADMTIKLWDFQG---FECIRTMHGHDHNVSSV----AIMPNG--DH-- 206

Query: 159 GQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIA 218
                      S   D  IK+W E + G     +    H +WVR V          + IA
Sbjct: 207 ---------IVSASRDKTIKMW-EVQTGYC--VKTFTGHREWVRMV----RPNQDGTLIA 250

Query: 219 SCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVS 266
           SCS D  V +W              L +   VV  +SW+  ++  ++S
Sbjct: 251 SCSNDQTVRVWVVATKECKA----ELREHEHVVECISWAPESSYSSIS 294


>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
          Length = 357

 Score = 64.3 bits (155), Expect = 1e-10
 Identities = 69/269 (25%), Positives = 109/269 (40%), Gaps = 38/269 (14%)

Query: 11  GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVI 70
           G+ LA+   DR + +++V  G     A L+GH G V ++ +     G++L S S D+ V 
Sbjct: 78  GSTLASAGFDRLILLWNVY-GDCDNYATLKGHSGAVMELHYNTD--GSMLFSASTDKTVA 134

Query: 71  IWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKK 130
           +W  E G  E+     GH S VNS C+       ++  GS DG + L        W+++K
Sbjct: 135 VWDSETG--ERVKRLKGHTSFVNS-CYPARRGPQLVCTGSDDGTVKL--------WDIRK 183

Query: 131 INNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKE 190
                T          AV      D           +  SGG DN IK+W   ++   K 
Sbjct: 184 KAAIQTF--QNTYQVLAVTFNDTSD-----------QIISGGIDNDIKVWDLRQN---KL 227

Query: 191 EQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKL----LHK 246
              +  H+D V  +    S+    S + S + D  V +W     +      K+    +H 
Sbjct: 228 TYTMRGHADSVTGL----SLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHN 283

Query: 247 FNDVVWHVSWSITANILAVSGGDNKVTLW 275
           F   +   SWS   + +A    D  V +W
Sbjct: 284 FEKNLLRCSWSPDGSKIAAGSADRFVYVW 312


>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
           sapiens]
          Length = 1205

 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 66/282 (23%), Positives = 105/282 (37%), Gaps = 57/282 (20%)

Query: 11  GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVI 70
           G R+A+C +D+++++F    G ++L  +++ HE  V   A++       +A+CS D+KV 
Sbjct: 627 GQRIASCGADKTLQVFKAETGEKLL--EIKAHEDEVLCCAFSTD--DRFIATCSVDKKVK 682

Query: 71  IWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKK 130
           IW    G  E  H +  H   VN   +    + L+LA GSSD  + L       Q E + 
Sbjct: 683 IWNSMTG--ELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDL---NQKECRN 737

Query: 131 INNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKE 190
               HT   N   ++P                   K  AS   D  +KLW      + K 
Sbjct: 738 TMFGHTNSVNHCRFSPD-----------------DKLLASCSADGTLKLWDATSANERKS 780

Query: 191 ----------EQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWS 240
                     E   E     V+  +W+             +   ++F+W  D  S     
Sbjct: 781 INVKQFFLNLEDPQEDMEVIVKCCSWSAD-----GARIMVAAKNKIFLWNTDSRS----- 830

Query: 241 PKLLHKFNDVVWHVSW------SITANILAVSGGDNKVTLWK 276
                K  D   H+SW      S   +    S  D  + LW+
Sbjct: 831 -----KVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 867


>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
           sapiens]
          Length = 1194

 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 66/282 (23%), Positives = 105/282 (37%), Gaps = 57/282 (20%)

Query: 11  GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVI 70
           G R+A+C +D+++++F    G ++L  +++ HE  V   A++       +A+CS D+KV 
Sbjct: 616 GQRIASCGADKTLQVFKAETGEKLL--EIKAHEDEVLCCAFSTD--DRFIATCSVDKKVK 671

Query: 71  IWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKK 130
           IW    G  E  H +  H   VN   +    + L+LA GSSD  + L       Q E + 
Sbjct: 672 IWNSMTG--ELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDL---NQKECRN 726

Query: 131 INNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKE 190
               HT   N   ++P                   K  AS   D  +KLW      + K 
Sbjct: 727 TMFGHTNSVNHCRFSPD-----------------DKLLASCSADGTLKLWDATSANERKS 769

Query: 191 ----------EQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWS 240
                     E   E     V+  +W+             +   ++F+W  D  S     
Sbjct: 770 INVKQFFLNLEDPQEDMEVIVKCCSWSAD-----GARIMVAAKNKIFLWNTDSRS----- 819

Query: 241 PKLLHKFNDVVWHVSW------SITANILAVSGGDNKVTLWK 276
                K  D   H+SW      S   +    S  D  + LW+
Sbjct: 820 -----KVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 856


>gi|19913367 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 62.8 bits (151), Expect = 4e-10
 Identities = 74/308 (24%), Positives = 114/308 (37%), Gaps = 83/308 (26%)

Query: 11  GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVI 70
           GT LA  S D   +I+   NG   L + L  H+GP++ + W     GN + S   D+  I
Sbjct: 247 GTLLAMGSYDGFARIW-TENGN--LASTLGQHKGPIFALKWNKK--GNYVLSAGVDKTTI 301

Query: 71  IWREENGT----------------WEKSHEHA-----------------------GHDSS 91
           IW    G                 W+ +   A                       GH + 
Sbjct: 302 IWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNE 361

Query: 92  VNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNA-----VSWAP 146
           VN++ W P   G++LA  S D  + +        W +K+    H +  ++     + W+P
Sbjct: 362 VNAIKWDPS--GMLLASCSDDMTLKI--------WSMKQDACVHDLQAHSKEIYTIKWSP 411

Query: 147 AVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAW 206
                     P+   PN     AS   D+ ++LW  E   Q      L  H + V  VA+
Sbjct: 412 T--------GPATSNPNSSIMLASASFDSTVRLWDVE---QGVCTHTLMKHQEPVYSVAF 460

Query: 207 APSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDV--VWHVSWSITANILA 264
           +P        +AS S D  V IW       NT S  L+H +     ++ V W+   + + 
Sbjct: 461 SPD----GKYLASGSFDKYVHIW-------NTQSGSLVHSYQGTGGIFEVCWNARGDKVG 509

Query: 265 VSGGDNKV 272
            S  D  V
Sbjct: 510 ASASDGSV 517



 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 71/265 (26%), Positives = 102/265 (38%), Gaps = 56/265 (21%)

Query: 39  LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR-EENGTWEKSH-------EHAGHD- 89
           LRGHE  V+  AW +P+  ++LAS S D    IW   EN     +           GHD 
Sbjct: 175 LRGHESEVFICAW-NPV-SDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 232

Query: 90  ---SSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAP 146
                V S+ W  +  G +LA GS DG   + T  G         N A T+G +      
Sbjct: 233 PSNKDVTSLDW--NSDGTLLAMGSYDGFARIWTENG---------NLASTLGQH------ 275

Query: 147 AVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAW 206
               G +      +K NY+    S G D    +W +   G+ K  Q+   HS    DV W
Sbjct: 276 ---KGPIFALKWNKKGNYV---LSAGVDKTTIIW-DAHTGEAK--QQFPFHSAPALDVDW 326

Query: 207 APSIGLPTSTIASCSQDGRVFIWT--CDDASSNTWSPKLLHKFNDVVWHVSWSITANILA 264
             ++     T ASCS D  + +    CD         K      + V  + W  +  +LA
Sbjct: 327 QNNM-----TFASCSTDMCIHVCRLGCDH------PVKTFQGHTNEVNAIKWDPSGMLLA 375

Query: 265 VSGGDNKVTLWKESVDGQWVCISDV 289
               D  + +W    D    C+ D+
Sbjct: 376 SCSDDMTLKIWSMKQD---ACVHDL 397



 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 34/105 (32%), Positives = 58/105 (55%), Gaps = 9/105 (8%)

Query: 14  LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR 73
           LA+ S D +V+++DV  G  +    L  H+ PV+ VA++    G  LAS S+D+ V IW 
Sbjct: 425 LASASFDSTVRLWDVEQG--VCTHTLMKHQEPVYSVAFSPD--GKYLASGSFDKYVHIWN 480

Query: 74  EENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLL 118
            ++G+   S++  G    +  VCW  +  G  +   +SDG++ +L
Sbjct: 481 TQSGSLVHSYQGTG---GIFEVCW--NARGDKVGASASDGSVCVL 520



 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 35/118 (29%), Positives = 57/118 (48%), Gaps = 13/118 (11%)

Query: 2   IHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWA-------HP 54
           ++  + D  G  LA+CS D ++KI+ ++      + DL+ H   ++ + W+       +P
Sbjct: 362 VNAIKWDPSGMLLASCSDDMTLKIWSMKQDA--CVHDLQAHSKEIYTIKWSPTGPATSNP 419

Query: 55  MYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSD 112
               +LAS S+D  V +W  E G    +H    H   V SV ++P   G  LA GS D
Sbjct: 420 NSSIMLASASFDSTVRLWDVEQGVC--THTLMKHQEPVYSVAFSPD--GKYLASGSFD 473



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 76/302 (25%), Positives = 115/302 (38%), Gaps = 56/302 (18%)

Query: 14  LATCSSDRSVKIFDVR---NGGQILIADLR------GHEGP----VWQVAWAHPMYGNIL 60
           LA+ S D + +I+++    NGG   +  LR      GH+ P    V  + W     G +L
Sbjct: 194 LASGSGDSTARIWNLNENSNGGSTQLV-LRHCIREGGHDVPSNKDVTSLDWNSD--GTLL 250

Query: 61  ASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY 120
           A  SYD    IW E         +H G    + ++ W       +L+ G     I    +
Sbjct: 251 AMGSYDGFARIWTENGNLASTLGQHKG---PIFALKWNKKG-NYVLSAGVDKTTIIWDAH 306

Query: 121 TGEGQ----------WEVKKINNAHTIGCNAVSWAPAVVPGSLIDHP------SGQKPNY 164
           TGE +           +V   NN     C+          G   DHP         + N 
Sbjct: 307 TGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLG--CDHPVKTFQGHTNEVNA 364

Query: 165 IKRFASG----GC--DNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWA---PSIGLPTS 215
           IK   SG     C  D  +K+W  ++D    +   L+AHS  +  + W+   P+   P S
Sbjct: 365 IKWDPSGMLLASCSDDMTLKIWSMKQDACVHD---LQAHSKEIYTIKWSPTGPATSNPNS 421

Query: 216 TI--ASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVT 273
           +I  AS S D  V +W  +           L K  + V+ V++S     LA    D  V 
Sbjct: 422 SIMLASASFDSTVRLWDVEQGVCT----HTLMKHQEPVYSVAFSPDGKYLASGSFDKYVH 477

Query: 274 LW 275
           +W
Sbjct: 478 IW 479


>gi|19913365 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 62.8 bits (151), Expect = 4e-10
 Identities = 74/308 (24%), Positives = 114/308 (37%), Gaps = 83/308 (26%)

Query: 11  GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVI 70
           GT LA  S D   +I+   NG   L + L  H+GP++ + W     GN + S   D+  I
Sbjct: 247 GTLLAMGSYDGFARIW-TENGN--LASTLGQHKGPIFALKWNKK--GNYVLSAGVDKTTI 301

Query: 71  IWREENGT----------------WEKSHEHA-----------------------GHDSS 91
           IW    G                 W+ +   A                       GH + 
Sbjct: 302 IWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNE 361

Query: 92  VNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNA-----VSWAP 146
           VN++ W P   G++LA  S D  + +        W +K+    H +  ++     + W+P
Sbjct: 362 VNAIKWDPS--GMLLASCSDDMTLKI--------WSMKQDACVHDLQAHSKEIYTIKWSP 411

Query: 147 AVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAW 206
                     P+   PN     AS   D+ ++LW  E   Q      L  H + V  VA+
Sbjct: 412 T--------GPATSNPNSSIMLASASFDSTVRLWDVE---QGVCTHTLMKHQEPVYSVAF 460

Query: 207 APSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDV--VWHVSWSITANILA 264
           +P        +AS S D  V IW       NT S  L+H +     ++ V W+   + + 
Sbjct: 461 SPD----GKYLASGSFDKYVHIW-------NTQSGSLVHSYQGTGGIFEVCWNARGDKVG 509

Query: 265 VSGGDNKV 272
            S  D  V
Sbjct: 510 ASASDGSV 517



 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 71/265 (26%), Positives = 102/265 (38%), Gaps = 56/265 (21%)

Query: 39  LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR-EENGTWEKSH-------EHAGHD- 89
           LRGHE  V+  AW +P+  ++LAS S D    IW   EN     +           GHD 
Sbjct: 175 LRGHESEVFICAW-NPV-SDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 232

Query: 90  ---SSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAP 146
                V S+ W  +  G +LA GS DG   + T  G         N A T+G +      
Sbjct: 233 PSNKDVTSLDW--NSDGTLLAMGSYDGFARIWTENG---------NLASTLGQH------ 275

Query: 147 AVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAW 206
               G +      +K NY+    S G D    +W +   G+ K  Q+   HS    DV W
Sbjct: 276 ---KGPIFALKWNKKGNYV---LSAGVDKTTIIW-DAHTGEAK--QQFPFHSAPALDVDW 326

Query: 207 APSIGLPTSTIASCSQDGRVFIWT--CDDASSNTWSPKLLHKFNDVVWHVSWSITANILA 264
             ++     T ASCS D  + +    CD         K      + V  + W  +  +LA
Sbjct: 327 QNNM-----TFASCSTDMCIHVCRLGCDH------PVKTFQGHTNEVNAIKWDPSGMLLA 375

Query: 265 VSGGDNKVTLWKESVDGQWVCISDV 289
               D  + +W    D    C+ D+
Sbjct: 376 SCSDDMTLKIWSMKQD---ACVHDL 397



 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 34/105 (32%), Positives = 58/105 (55%), Gaps = 9/105 (8%)

Query: 14  LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR 73
           LA+ S D +V+++DV  G  +    L  H+ PV+ VA++    G  LAS S+D+ V IW 
Sbjct: 425 LASASFDSTVRLWDVEQG--VCTHTLMKHQEPVYSVAFSPD--GKYLASGSFDKYVHIWN 480

Query: 74  EENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLL 118
            ++G+   S++  G    +  VCW  +  G  +   +SDG++ +L
Sbjct: 481 TQSGSLVHSYQGTG---GIFEVCW--NARGDKVGASASDGSVCVL 520



 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 35/118 (29%), Positives = 57/118 (48%), Gaps = 13/118 (11%)

Query: 2   IHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWA-------HP 54
           ++  + D  G  LA+CS D ++KI+ ++      + DL+ H   ++ + W+       +P
Sbjct: 362 VNAIKWDPSGMLLASCSDDMTLKIWSMKQDA--CVHDLQAHSKEIYTIKWSPTGPATSNP 419

Query: 55  MYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSD 112
               +LAS S+D  V +W  E G    +H    H   V SV ++P   G  LA GS D
Sbjct: 420 NSSIMLASASFDSTVRLWDVEQGVC--THTLMKHQEPVYSVAFSPD--GKYLASGSFD 473



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 76/302 (25%), Positives = 115/302 (38%), Gaps = 56/302 (18%)

Query: 14  LATCSSDRSVKIFDVR---NGGQILIADLR------GHEGP----VWQVAWAHPMYGNIL 60
           LA+ S D + +I+++    NGG   +  LR      GH+ P    V  + W     G +L
Sbjct: 194 LASGSGDSTARIWNLNENSNGGSTQLV-LRHCIREGGHDVPSNKDVTSLDWNSD--GTLL 250

Query: 61  ASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY 120
           A  SYD    IW E         +H G    + ++ W       +L+ G     I    +
Sbjct: 251 AMGSYDGFARIWTENGNLASTLGQHKG---PIFALKWNKKG-NYVLSAGVDKTTIIWDAH 306

Query: 121 TGEGQ----------WEVKKINNAHTIGCNAVSWAPAVVPGSLIDHP------SGQKPNY 164
           TGE +           +V   NN     C+          G   DHP         + N 
Sbjct: 307 TGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLG--CDHPVKTFQGHTNEVNA 364

Query: 165 IKRFASG----GC--DNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWA---PSIGLPTS 215
           IK   SG     C  D  +K+W  ++D    +   L+AHS  +  + W+   P+   P S
Sbjct: 365 IKWDPSGMLLASCSDDMTLKIWSMKQDACVHD---LQAHSKEIYTIKWSPTGPATSNPNS 421

Query: 216 TI--ASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVT 273
           +I  AS S D  V +W  +           L K  + V+ V++S     LA    D  V 
Sbjct: 422 SIMLASASFDSTVRLWDVEQGVCT----HTLMKHQEPVYSVAFSPDGKYLASGSFDKYVH 477

Query: 274 LW 275
           +W
Sbjct: 478 IW 479


>gi|15150805 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 62.8 bits (151), Expect = 4e-10
 Identities = 74/308 (24%), Positives = 114/308 (37%), Gaps = 83/308 (26%)

Query: 11  GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVI 70
           GT LA  S D   +I+   NG   L + L  H+GP++ + W     GN + S   D+  I
Sbjct: 247 GTLLAMGSYDGFARIW-TENGN--LASTLGQHKGPIFALKWNKK--GNYVLSAGVDKTTI 301

Query: 71  IWREENGT----------------WEKSHEHA-----------------------GHDSS 91
           IW    G                 W+ +   A                       GH + 
Sbjct: 302 IWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNE 361

Query: 92  VNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNA-----VSWAP 146
           VN++ W P   G++LA  S D  + +        W +K+    H +  ++     + W+P
Sbjct: 362 VNAIKWDPS--GMLLASCSDDMTLKI--------WSMKQDACVHDLQAHSKEIYTIKWSP 411

Query: 147 AVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAW 206
                     P+   PN     AS   D+ ++LW  E   Q      L  H + V  VA+
Sbjct: 412 T--------GPATSNPNSSIMLASASFDSTVRLWDVE---QGVCTHTLMKHQEPVYSVAF 460

Query: 207 APSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDV--VWHVSWSITANILA 264
           +P        +AS S D  V IW       NT S  L+H +     ++ V W+   + + 
Sbjct: 461 SPD----GKYLASGSFDKYVHIW-------NTQSGSLVHSYQGTGGIFEVCWNARGDKVG 509

Query: 265 VSGGDNKV 272
            S  D  V
Sbjct: 510 ASASDGSV 517



 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 71/265 (26%), Positives = 102/265 (38%), Gaps = 56/265 (21%)

Query: 39  LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR-EENGTWEKSH-------EHAGHD- 89
           LRGHE  V+  AW +P+  ++LAS S D    IW   EN     +           GHD 
Sbjct: 175 LRGHESEVFICAW-NPV-SDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 232

Query: 90  ---SSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAP 146
                V S+ W  +  G +LA GS DG   + T  G         N A T+G +      
Sbjct: 233 PSNKDVTSLDW--NSDGTLLAMGSYDGFARIWTENG---------NLASTLGQH------ 275

Query: 147 AVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAW 206
               G +      +K NY+    S G D    +W +   G+ K  Q+   HS    DV W
Sbjct: 276 ---KGPIFALKWNKKGNYV---LSAGVDKTTIIW-DAHTGEAK--QQFPFHSAPALDVDW 326

Query: 207 APSIGLPTSTIASCSQDGRVFIWT--CDDASSNTWSPKLLHKFNDVVWHVSWSITANILA 264
             ++     T ASCS D  + +    CD         K      + V  + W  +  +LA
Sbjct: 327 QNNM-----TFASCSTDMCIHVCRLGCDH------PVKTFQGHTNEVNAIKWDPSGMLLA 375

Query: 265 VSGGDNKVTLWKESVDGQWVCISDV 289
               D  + +W    D    C+ D+
Sbjct: 376 SCSDDMTLKIWSMKQD---ACVHDL 397



 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 34/105 (32%), Positives = 58/105 (55%), Gaps = 9/105 (8%)

Query: 14  LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR 73
           LA+ S D +V+++DV  G  +    L  H+ PV+ VA++    G  LAS S+D+ V IW 
Sbjct: 425 LASASFDSTVRLWDVEQG--VCTHTLMKHQEPVYSVAFSPD--GKYLASGSFDKYVHIWN 480

Query: 74  EENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLL 118
            ++G+   S++  G    +  VCW  +  G  +   +SDG++ +L
Sbjct: 481 TQSGSLVHSYQGTG---GIFEVCW--NARGDKVGASASDGSVCVL 520



 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 35/118 (29%), Positives = 57/118 (48%), Gaps = 13/118 (11%)

Query: 2   IHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWA-------HP 54
           ++  + D  G  LA+CS D ++KI+ ++      + DL+ H   ++ + W+       +P
Sbjct: 362 VNAIKWDPSGMLLASCSDDMTLKIWSMKQDA--CVHDLQAHSKEIYTIKWSPTGPATSNP 419

Query: 55  MYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSD 112
               +LAS S+D  V +W  E G    +H    H   V SV ++P   G  LA GS D
Sbjct: 420 NSSIMLASASFDSTVRLWDVEQGVC--THTLMKHQEPVYSVAFSPD--GKYLASGSFD 473



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 76/302 (25%), Positives = 115/302 (38%), Gaps = 56/302 (18%)

Query: 14  LATCSSDRSVKIFDVR---NGGQILIADLR------GHEGP----VWQVAWAHPMYGNIL 60
           LA+ S D + +I+++    NGG   +  LR      GH+ P    V  + W     G +L
Sbjct: 194 LASGSGDSTARIWNLNENSNGGSTQLV-LRHCIREGGHDVPSNKDVTSLDWNSD--GTLL 250

Query: 61  ASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY 120
           A  SYD    IW E         +H G    + ++ W       +L+ G     I    +
Sbjct: 251 AMGSYDGFARIWTENGNLASTLGQHKG---PIFALKWNKKG-NYVLSAGVDKTTIIWDAH 306

Query: 121 TGEGQ----------WEVKKINNAHTIGCNAVSWAPAVVPGSLIDHP------SGQKPNY 164
           TGE +           +V   NN     C+          G   DHP         + N 
Sbjct: 307 TGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLG--CDHPVKTFQGHTNEVNA 364

Query: 165 IKRFASG----GC--DNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWA---PSIGLPTS 215
           IK   SG     C  D  +K+W  ++D    +   L+AHS  +  + W+   P+   P S
Sbjct: 365 IKWDPSGMLLASCSDDMTLKIWSMKQDACVHD---LQAHSKEIYTIKWSPTGPATSNPNS 421

Query: 216 TI--ASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVT 273
           +I  AS S D  V +W  +           L K  + V+ V++S     LA    D  V 
Sbjct: 422 SIMLASASFDSTVRLWDVEQGVCT----HTLMKHQEPVYSVAFSPDGKYLASGSFDKYVH 477

Query: 274 LW 275
           +W
Sbjct: 478 IW 479


>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
           sapiens]
          Length = 1248

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 47/170 (27%), Positives = 74/170 (43%), Gaps = 26/170 (15%)

Query: 11  GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVI 70
           G R+A+C +D+++++F    G ++L  +++ HE  V   A++       +A+CS D+KV 
Sbjct: 627 GQRIASCGADKTLQVFKAETGEKLL--EIKAHEDEVLCCAFSTD--DRFIATCSVDKKVK 682

Query: 71  IWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKK 130
           IW    G  E  H +  H   VN   +    + L+LA GSSD  + L       Q E + 
Sbjct: 683 IWNSMTG--ELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDL---NQKECRN 737

Query: 131 INNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLW 180
               HT   N   ++P                   K  AS   D  +KLW
Sbjct: 738 TMFGHTNSVNHCRFSPD-----------------DKLLASCSADGTLKLW 770



 Score = 33.1 bits (74), Expect = 0.32
 Identities = 31/115 (26%), Positives = 53/115 (46%), Gaps = 19/115 (16%)

Query: 166 KRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGR 225
           +R AS G D  ++++K E   +  E   ++AH D V   A++         IA+CS D +
Sbjct: 628 QRIASCGADKTLQVFKAETGEKLLE---IKAHEDEVLCCAFSTD----DRFIATCSVDKK 680

Query: 226 VFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITAN-----ILAVSGGDNKVTLW 275
           V IW       N+ + +L+H +++    V+     N     +LA    D  + LW
Sbjct: 681 VKIW-------NSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLW 728



 Score = 32.7 bits (73), Expect = 0.42
 Identities = 46/199 (23%), Positives = 80/199 (40%), Gaps = 35/199 (17%)

Query: 39  LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWA 98
           +R H   V+   ++    G  +ASC  D+ + +++ E G  EK  E   H+  V  +C A
Sbjct: 611 VRPHTDAVYHACFSED--GQRIASCGADKTLQVFKAETG--EKLLEIKAHEDEV--LCCA 664

Query: 99  PHDYGLILACGSSDGAISLL-TYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHP 157
                  +A  S D  + +  + TGE    +    + H+   N   +  +          
Sbjct: 665 FSTDDRFIATCSVDKKVKIWNSMTGE----LVHTYDEHSEQVNCCHFTNS---------- 710

Query: 158 SGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKE-EQKLEAHSDWVRDVAWAPSIGLPTST 216
                ++    A+G  D  +KLW    D   KE    +  H++ V    ++P   L    
Sbjct: 711 -----SHHLLLATGSSDCFLKLW----DLNQKECRNTMFGHTNSVNHCRFSPDDKL---- 757

Query: 217 IASCSQDGRVFIWTCDDAS 235
           +ASCS DG + +W    A+
Sbjct: 758 LASCSADGTLKLWDATSAN 776


>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
           sapiens]
          Length = 1237

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 47/170 (27%), Positives = 74/170 (43%), Gaps = 26/170 (15%)

Query: 11  GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVI 70
           G R+A+C +D+++++F    G ++L  +++ HE  V   A++       +A+CS D+KV 
Sbjct: 616 GQRIASCGADKTLQVFKAETGEKLL--EIKAHEDEVLCCAFSTD--DRFIATCSVDKKVK 671

Query: 71  IWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKK 130
           IW    G  E  H +  H   VN   +    + L+LA GSSD  + L       Q E + 
Sbjct: 672 IWNSMTG--ELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDL---NQKECRN 726

Query: 131 INNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLW 180
               HT   N   ++P                   K  AS   D  +KLW
Sbjct: 727 TMFGHTNSVNHCRFSPD-----------------DKLLASCSADGTLKLW 759



 Score = 33.1 bits (74), Expect = 0.32
 Identities = 31/115 (26%), Positives = 53/115 (46%), Gaps = 19/115 (16%)

Query: 166 KRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGR 225
           +R AS G D  ++++K E   +  E   ++AH D V   A++         IA+CS D +
Sbjct: 617 QRIASCGADKTLQVFKAETGEKLLE---IKAHEDEVLCCAFSTD----DRFIATCSVDKK 669

Query: 226 VFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITAN-----ILAVSGGDNKVTLW 275
           V IW       N+ + +L+H +++    V+     N     +LA    D  + LW
Sbjct: 670 VKIW-------NSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLW 717



 Score = 32.7 bits (73), Expect = 0.42
 Identities = 46/199 (23%), Positives = 80/199 (40%), Gaps = 35/199 (17%)

Query: 39  LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWA 98
           +R H   V+   ++    G  +ASC  D+ + +++ E G  EK  E   H+  V  +C A
Sbjct: 600 VRPHTDAVYHACFSED--GQRIASCGADKTLQVFKAETG--EKLLEIKAHEDEV--LCCA 653

Query: 99  PHDYGLILACGSSDGAISLL-TYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHP 157
                  +A  S D  + +  + TGE    +    + H+   N   +  +          
Sbjct: 654 FSTDDRFIATCSVDKKVKIWNSMTGE----LVHTYDEHSEQVNCCHFTNS---------- 699

Query: 158 SGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKE-EQKLEAHSDWVRDVAWAPSIGLPTST 216
                ++    A+G  D  +KLW    D   KE    +  H++ V    ++P   L    
Sbjct: 700 -----SHHLLLATGSSDCFLKLW----DLNQKECRNTMFGHTNSVNHCRFSPDDKL---- 746

Query: 217 IASCSQDGRVFIWTCDDAS 235
           +ASCS DG + +W    A+
Sbjct: 747 LASCSADGTLKLWDATSAN 765


>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
          Length = 589

 Score = 59.3 bits (142), Expect = 4e-09
 Identities = 60/219 (27%), Positives = 100/219 (45%), Gaps = 41/219 (18%)

Query: 14  LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR 73
           L +CS D S++ +D+ +    ++   +GH  PVW +  +   Y    AS S+DR   +W 
Sbjct: 357 LLSCSEDMSIRYWDLGSFTNTVL--YQGHAYPVWDLDISP--YSLYFASGSHDRTARLW- 411

Query: 74  EENGTWEKSHE---HAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKK 130
               ++++++    +AGH + V+ V + P+     LA GS+D  + L        W  ++
Sbjct: 412 ----SFDRTYPLRIYAGHLADVDCVKFHPNSN--YLATGSTDKTVRL--------WSAQQ 457

Query: 131 INNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKE 190
            N+      +     P +   SL   P+G      K  AS G D  +KLW       +KE
Sbjct: 458 GNSVRLFTGHR---GPVL---SLAFSPNG------KYLASAGEDQRLKLWDLASGTLYKE 505

Query: 191 EQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIW 229
              L  H+D +  + ++P  GL    IAS S D  V +W
Sbjct: 506 ---LRGHTDNITSLTFSPDSGL----IASASMDNSVRVW 537



 Score = 52.8 bits (125), Expect = 4e-07
 Identities = 60/237 (25%), Positives = 101/237 (42%), Gaps = 37/237 (15%)

Query: 39  LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWA 98
           LRGH GPV+   +     G  L SCS D  +  W  + G++  +  + GH   V  +  +
Sbjct: 338 LRGHCGPVYSTRFLADSSG--LLSCSEDMSIRYW--DLGSFTNTVLYQGHAYPVWDLDIS 393

Query: 99  PHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPS 158
           P  Y L  A GS D    L ++    +    +I   H    + V +           HP+
Sbjct: 394 P--YSLYFASGSHDRTARLWSFD---RTYPLRIYAGHLADVDCVKF-----------HPN 437

Query: 159 GQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIA 218
               NY+   A+G  D  ++LW  +   Q    +    H   V  +A++P+       +A
Sbjct: 438 S---NYL---ATGSTDKTVRLWSAQ---QGNSVRLFTGHRGPVLSLAFSPN----GKYLA 484

Query: 219 SCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 275
           S  +D R+ +W   D +S T   K L    D +  +++S  + ++A +  DN V +W
Sbjct: 485 SAGEDQRLKLW---DLASGTLY-KELRGHTDNITSLTFSPDSGLIASASMDNSVRVW 537


>gi|19913369 transducin beta-like 3 [Homo sapiens]
          Length = 808

 Score = 58.2 bits (139), Expect = 9e-09
 Identities = 69/286 (24%), Positives = 110/286 (38%), Gaps = 48/286 (16%)

Query: 11  GTRLATCSSDRSVKIFDVRNGGQIL-IADLRGHEGPVWQVAWAHPMYGNILASCSYDRKV 69
           G   A+C+ D+SV+I+ +   GQ++ +A   GH   V  V  +  +  + L + S D  V
Sbjct: 388 GWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSR-LKESFLVTGSQDCTV 446

Query: 70  IIW-----------REENG--TWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAIS 116
            +W             +NG    +       HD  +NSV  AP+D   +LA GS D    
Sbjct: 447 KLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPND--KLLATGSQDRTAK 504

Query: 117 LLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNL 176
           L       Q ++  + + H  G   V ++P                   +  A+   D  
Sbjct: 505 LWALP---QCQLLGVFSGHRRGLWCVQFSP-----------------MDQVLATASADGT 544

Query: 177 IKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASS 236
           IKLW  ++    K     E H   V  VA+        + + S   DG V +WT      
Sbjct: 545 IKLWALQDFSCLK---TFEGHDASVLKVAFVSR----GTQLLSSGSDGLVKLWTI----K 593

Query: 237 NTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQ 282
           N    + L    D VW +  S   +       D++V LWK+  + +
Sbjct: 594 NNECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILWKDVTEAE 639



 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 48/180 (26%), Positives = 77/180 (42%), Gaps = 30/180 (16%)

Query: 14  LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR 73
           LAT S DR+ K++ +      L+    GH   +W V ++ PM   +LA+ S D  + +W 
Sbjct: 494 LATGSQDRTAKLWALPQCQ--LLGVFSGHRRGLWCVQFS-PM-DQVLATASADGTIKLWA 549

Query: 74  EENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINN 133
            ++ +  K+ E  GHD+SV  V +     G  L    SDG + L        W +K    
Sbjct: 550 LQDFSCLKTFE--GHDASVLKVAFVSR--GTQLLSSGSDGLVKL--------WTIKNNEC 597

Query: 134 AHTIGCNAVS-WAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQ 192
             T+  +    W   +    L DH             +G  D+ + LWK+  + +  EEQ
Sbjct: 598 VRTLDAHEDKVWG--LHCSRLDDHA-----------LTGASDSRVILWKDVTEAEQAEEQ 644


>gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]
          Length = 425

 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 58/239 (24%), Positives = 100/239 (41%), Gaps = 52/239 (21%)

Query: 14  LATCSSDRSVKIFDVRNG---GQILIAD--LRGHEGPVWQVAWAHPMYGNILASCSYDRK 68
           L + S D +V ++D+  G   G+I+ A     GH   V  VAW H ++ ++  S + D+K
Sbjct: 192 LLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAW-HLLHESLFGSVADDQK 250

Query: 69  VIIWREENGTWEK-SHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWE 127
           ++IW   + T  K SH    H + VN + + P+    ILA GS+D  ++L        W+
Sbjct: 251 LMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYS-EFILATGSADKTVAL--------WD 301

Query: 128 VKKIN------NAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWK 181
           ++ +        +H      V W+                P+     AS G D  + +W 
Sbjct: 302 LRNLKLKLHTFESHKDEIFQVHWS----------------PHNETILASSGTDRRLNVWD 345

Query: 182 EEEDGQWKEEQKLE-----------AHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIW 229
             + G+ +  +  E            H+  + D +W P+       I S S+D  + IW
Sbjct: 346 LSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPN---EPWVICSVSEDNIMQIW 401



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 61/288 (21%), Positives = 107/288 (37%), Gaps = 58/288 (20%)

Query: 39  LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHA-----GHDSSVN 93
           LRGH+   + ++W   + G++L S S D  V +W    G  E     A     GH + V 
Sbjct: 172 LRGHQKEGYGLSWNSNLSGHLL-SASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVE 230

Query: 94  SVCW-APHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGS 152
            V W   H+   +    + D  + +         +   + +AHT   N +S+ P      
Sbjct: 231 DVAWHLLHE--SLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNP------ 282

Query: 153 LIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGL 212
                      +I   A+G  D  + LW  +      +    E+H D +  V W+P    
Sbjct: 283 --------YSEFI--LATGSADKTVALW--DLRNLKLKLHTFESHKDEIFQVHWSPH--- 327

Query: 213 PTSTIASCSQDGRVFIW---------TCDDASSNTWSPKLLH-----KFNDVVWHVS--W 256
             + +AS   D R+ +W         + +DA         +H     K +D  W+ +  W
Sbjct: 328 NETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPW 387

Query: 257 SITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVSASVTEGQ 304
                ++     DN + +W+       +  +  N  +  V+ S  EGQ
Sbjct: 388 -----VICSVSEDNIMQIWQ-------MAENIYNDEESDVTTSELEGQ 423


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score = 55.1 bits (131), Expect = 8e-08
 Identities = 71/249 (28%), Positives = 101/249 (40%), Gaps = 36/249 (14%)

Query: 30  NGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHD 89
           N    L   L GH   V  V ++    G  LAS S DR +IIW   +G +EK+    GH+
Sbjct: 28  NPNYALKCTLVGHTEAVSSVKFSPN--GEWLASSSADRLIIIWGAYDGKYEKT--LYGHN 83

Query: 90  SSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVV 149
             ++ V W+     L+ A  S D  + L         +  K ++ +   CN   + P   
Sbjct: 84  LEISDVAWSSDSSRLVSA--SDDKTLKLWDVRSGKCLKTLKGHSNYVFCCN---FNP--- 135

Query: 150 PGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPS 209
           P +LI               SG  D  +K+W+ +     K  + L AHSD V  V +  S
Sbjct: 136 PSNLI--------------ISGSFDETVKIWEVKTG---KCLKTLSAHSDPVSAVHFNCS 178

Query: 210 IGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGD 269
                S I S S DG   IW   DA+S      L+   N  V  V +S     +  +  D
Sbjct: 179 ----GSLIVSGSYDGLCRIW---DAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLD 231

Query: 270 NKVTLWKES 278
           N + LW  S
Sbjct: 232 NTLKLWDYS 240



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 67/258 (25%), Positives = 110/258 (42%), Gaps = 47/258 (18%)

Query: 2   IHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILA 61
           I D       +RL + S D+++K++DVR+G    +  L+GH   V+   +  P   N++ 
Sbjct: 86  ISDVAWSSDSSRLVSASDDKTLKLWDVRSGK--CLKTLKGHSNYVFCCNFNPP--SNLII 141

Query: 62  SCSYDRKVIIWREENGTWEKS-HEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY 120
           S S+D  V IW  + G   K+   H+   S+V+  C      G ++  GS DG +  +  
Sbjct: 142 SGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNC-----SGSLIVSGSYDG-LCRIWD 195

Query: 121 TGEGQWEVKKINNAHTIGCNAVSWAP-------AVVPGSL----------IDHPSGQKPN 163
              GQ  +K + +      + V ++P       A +  +L          +   +G K  
Sbjct: 196 AASGQC-LKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNE 254

Query: 164 YIKRFA-----------SGGCDNLIKLWKEEEDGQWKE-EQKLEAHSDWVRDVAWAPSIG 211
               FA           SG  DNL+ +W    + Q KE  QKL+ H+D V   A  P+  
Sbjct: 255 KYCIFANFSVTGGKWIVSGSEDNLVYIW----NLQTKEIVQKLQGHTDVVISAACHPTEN 310

Query: 212 LPTSTIASCSQDGRVFIW 229
           L  S  A+   D  + +W
Sbjct: 311 LIAS--AALENDKTIKLW 326


>gi|14150171 THO complex 3 [Homo sapiens]
          Length = 351

 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 51/204 (25%), Positives = 89/204 (43%), Gaps = 27/204 (13%)

Query: 2   IHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILA 61
           +H       G RLA+ S D++  +F +     +   + RGH   V Q+ W HP   ++  
Sbjct: 58  VHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCW-HPSNPDLFV 116

Query: 62  SCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLL--- 118
           + S D+ + IW         +    G +    ++CW+P   G  +A G+ D  ++ +   
Sbjct: 117 TASGDKTIRIWDVRTTKCIATVNTKGENI---NICWSPD--GQTIAVGNKDDVVTFIDAK 171

Query: 119 TYTGEGQ----WEVKKI--NNAHTI-------GCNAVSWAPAVVPGSLID-HPSG----Q 160
           T+  + +    +EV +I  NN + +       GC  +   P + P   I+ HPS     +
Sbjct: 172 THRSKAEEQFKFEVNEISWNNDNNMFFLTNGNGCINILSYPELKPVQSINAHPSNCICIK 231

Query: 161 KPNYIKRFASGGCDNLIKLWKEEE 184
                K FA+G  D L+ LW  +E
Sbjct: 232 FDPMGKYFATGSADALVSLWDVDE 255



 Score = 42.4 bits (98), Expect = 5e-04
 Identities = 33/109 (30%), Positives = 49/109 (44%), Gaps = 15/109 (13%)

Query: 42  HEGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHD 101
           H   V  VAW+    G  LAS S+D+   ++  E     K + + GH  SV+ +CW P +
Sbjct: 54  HSAKVHSVAWSCD--GRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWHPSN 111

Query: 102 YGLILACGSSDGAISLLTYTGEGQWEV---KKINNAHTIGCNA-VSWAP 146
             L +   S D  I +        W+V   K I   +T G N  + W+P
Sbjct: 112 PDLFVT-ASGDKTIRI--------WDVRTTKCIATVNTKGENINICWSP 151


>gi|237820620 glutamate-rich WD repeat containing 1 [Homo sapiens]
          Length = 446

 Score = 52.8 bits (125), Expect = 4e-07
 Identities = 32/115 (27%), Positives = 46/115 (40%), Gaps = 4/115 (3%)

Query: 162 PNYIKRFASGGCDNLIKLWKEEEDGQWKEEQK-LEAHSDWVRDVAWAPSIGLPTSTIASC 220
           P    R  +G C   I LW   + G W  +Q+    H+  V D+ W+P+     +  ASC
Sbjct: 224 PRVTGRLLTGDCQKNIHLWTPTDGGSWHVDQRPFVGHTRSVEDLQWSPT---ENTVFASC 280

Query: 221 SQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 275
           S D  + IW    A S           +  V  +SWS     L   G D  + +W
Sbjct: 281 SADASIRIWDIRAAPSKACMLTTATAHDGDVNVISWSRREPFLLSGGDDGALKIW 335



 Score = 42.0 bits (97), Expect = 7e-04
 Identities = 42/205 (20%), Positives = 76/205 (37%), Gaps = 41/205 (20%)

Query: 36  IADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWRE-ENGTWEKSHE-HAGHDSSVN 93
           I    GH G  + + W+  + G +L      + + +W   + G+W        GH  SV 
Sbjct: 207 IFSFAGHMGEGFALDWSPRVTGRLLTG-DCQKNIHLWTPTDGGSWHVDQRPFVGHTRSVE 265

Query: 94  SVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINN---------AHTIGCNAVSW 144
            + W+P +  +  +C S+D +I +        W+++   +         AH    N +SW
Sbjct: 266 DLQWSPTENTVFASC-SADASIRI--------WDIRAAPSKACMLTTATAHDGDVNVISW 316

Query: 145 APAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDV 204
                        S ++P  +    SGG D  +K+W   +          + H   V  V
Sbjct: 317 -------------SRREPFLL----SGGDDGALKIWDLRQFKSGSPVATFKQHVAPVTSV 359

Query: 205 AWAPSIGLPTSTIASCSQDGRVFIW 229
            W P     +   A+   D ++  W
Sbjct: 360 EWHPQ---DSGVFAASGADHQITQW 381



 Score = 41.6 bits (96), Expect = 9e-04
 Identities = 42/174 (24%), Positives = 70/174 (40%), Gaps = 27/174 (15%)

Query: 13  RLATCSSDRSVKIFDVRNGGQILIADLR---GHEGPVWQVAWAHPMYGNILASCSYDRKV 69
           RL T    +++ ++   +GG   + D R   GH   V  + W+ P    + ASCS D  +
Sbjct: 229 RLLTGDCQKNIHLWTPTDGGSWHV-DQRPFVGHTRSVEDLQWS-PTENTVFASCSADASI 286

Query: 70  IIW--REENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWE 127
            IW  R              HD  VN + W+  +    L  G  DGA+ +        W+
Sbjct: 287 RIWDIRAAPSKACMLTTATAHDGDVNVISWSRRE--PFLLSGGDDGALKI--------WD 336

Query: 128 VKKINNAHTIGCNAVSWAPAVVPGSLID-HPSGQKPNYIKRFASGGCDNLIKLW 180
           +++  +    G    ++   V P + ++ HP          FA+ G D+ I  W
Sbjct: 337 LRQFKS----GSPVATFKQHVAPVTSVEWHPQDSGV-----FAASGADHQITQW 381



 Score = 38.1 bits (87), Expect = 0.010
 Identities = 29/104 (27%), Positives = 51/104 (49%), Gaps = 9/104 (8%)

Query: 12  TRLATCSSDRSVKIFDVRNGGQ--ILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKV 69
           T  A+CS+D S++I+D+R       ++     H+G V  ++W+       L S   D  +
Sbjct: 275 TVFASCSADASIRIWDIRAAPSKACMLTTATAHDGDVNVISWSR--REPFLLSGGDDGAL 332

Query: 70  IIW---REENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGS 110
            IW   + ++G+   + +   H + V SV W P D G+  A G+
Sbjct: 333 KIWDLRQFKSGSPVATFKQ--HVAPVTSVEWHPQDSGVFAASGA 374


>gi|223029510 echinoderm microtubule associated protein like 4
           isoform b [Homo sapiens]
          Length = 923

 Score = 52.8 bits (125), Expect = 4e-07
 Identities = 56/247 (22%), Positives = 98/247 (39%), Gaps = 47/247 (19%)

Query: 38  DLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR--EENGTWEKSHEHAGHDSSVNSV 95
           +++GH   +W +A  HP + ++L +C+ DR+V +W   E    W +  +  GH       
Sbjct: 529 EVQGHTDELWGLA-THP-FKDLLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGH------- 579

Query: 96  CWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLID 155
           C   H  G ++A G+  G   +L        E + + + HT G   +S     + G+ + 
Sbjct: 580 CADFHPSGTVVAIGTHSGRWFVL------DAETRDLVSIHTDGNEQLSVMRYSIDGTFL- 632

Query: 156 HPSGQKPNYIKRFASGGCDNLIKLWKEEEDG-QWKEEQKLEAHSDWVRDVAWAPSIGLPT 214
                        A G  DN I L+   E+G ++    +   HS ++  + W+P      
Sbjct: 633 -------------AVGSHDNFIYLYVVSENGRKYSRYGRCTGHSSYITHLDWSPD----N 675

Query: 215 STIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTL 274
             I S S D  +  W   +        KL+   +D    + W+    +L    G     +
Sbjct: 676 KYIMSNSGDYEILYWDIPNGC------KLIRNRSDCK-DIDWTTYTCVL----GFQVFGV 724

Query: 275 WKESVDG 281
           W E  DG
Sbjct: 725 WPEGSDG 731


>gi|19923497 echinoderm microtubule associated protein like 4
           isoform a [Homo sapiens]
          Length = 981

 Score = 52.8 bits (125), Expect = 4e-07
 Identities = 56/247 (22%), Positives = 98/247 (39%), Gaps = 47/247 (19%)

Query: 38  DLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR--EENGTWEKSHEHAGHDSSVNSV 95
           +++GH   +W +A  HP + ++L +C+ DR+V +W   E    W +  +  GH       
Sbjct: 587 EVQGHTDELWGLA-THP-FKDLLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGH------- 637

Query: 96  CWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLID 155
           C   H  G ++A G+  G   +L        E + + + HT G   +S     + G+ + 
Sbjct: 638 CADFHPSGTVVAIGTHSGRWFVL------DAETRDLVSIHTDGNEQLSVMRYSIDGTFL- 690

Query: 156 HPSGQKPNYIKRFASGGCDNLIKLWKEEEDG-QWKEEQKLEAHSDWVRDVAWAPSIGLPT 214
                        A G  DN I L+   E+G ++    +   HS ++  + W+P      
Sbjct: 691 -------------AVGSHDNFIYLYVVSENGRKYSRYGRCTGHSSYITHLDWSPD----N 733

Query: 215 STIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTL 274
             I S S D  +  W   +        KL+   +D    + W+    +L    G     +
Sbjct: 734 KYIMSNSGDYEILYWDIPNGC------KLIRNRSDCK-DIDWTTYTCVL----GFQVFGV 782

Query: 275 WKESVDG 281
           W E  DG
Sbjct: 783 WPEGSDG 789


>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
           sapiens]
          Length = 514

 Score = 52.8 bits (125), Expect = 4e-07
 Identities = 73/263 (27%), Positives = 102/263 (38%), Gaps = 52/263 (19%)

Query: 39  LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR-EENGTWEKSH-------EHAGHD- 89
           LRGHE  V+  AW +P+  ++LAS S D    IW   EN T   +           G D 
Sbjct: 165 LRGHESEVFICAW-NPV-SDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDV 222

Query: 90  ---SSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAP 146
                V S+ W  +  G +LA GS DG   + T  G         N A T+G +      
Sbjct: 223 PSNKDVTSLDW--NSEGTLLATGSYDGFARIWTKDG---------NLASTLGQH------ 265

Query: 147 AVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAW 206
               G +      +K N+I    S G D    +W +   G+ K  Q+   HS    DV W
Sbjct: 266 ---KGPIFALKWNKKGNFI---LSAGVDKTTIIW-DAHTGEAK--QQFPFHSAPALDVDW 316

Query: 207 APSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVS 266
             +     +T ASCS D  + I  C          K      + V  + W  T N+LA  
Sbjct: 317 QSN-----NTFASCSTD--MCIHVCKLGQDR--PIKTFQGHTNEVNAIKWDPTGNLLASC 367

Query: 267 GGDNKVTLWKESVDGQWVCISDV 289
             D  + +W    D    C+ D+
Sbjct: 368 SDDMTLKIWSMKQDN---CVHDL 387



 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 36/105 (34%), Positives = 56/105 (53%), Gaps = 9/105 (8%)

Query: 14  LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR 73
           LA+ S D +V+++DV  G  I I  L  H+ PV+ VA++    G  LAS S+D+ V IW 
Sbjct: 415 LASASFDSTVRLWDVDRG--ICIHTLTKHQEPVYSVAFSPD--GRYLASGSFDKCVHIWN 470

Query: 74  EENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLL 118
            + G    S+   G    +  VCW  +  G  +   +SDG++ +L
Sbjct: 471 TQTGALVHSYRGTG---GIFEVCW--NAAGDKVGASASDGSVCVL 510



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 45/178 (25%), Positives = 73/178 (41%), Gaps = 37/178 (20%)

Query: 15  ATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIW-- 72
           A+CS+D  + +  +  G    I   +GH   V  + W     GN+LASCS D  + IW  
Sbjct: 323 ASCSTDMCIHVCKL--GQDRPIKTFQGHTNEVNAIKWDPT--GNLLASCSDDMTLKIWSM 378

Query: 73  REENGTWEKSHEHAGHDSSVNSVCWAPHDYG-------LILACGSSDGAISLLTYTGEGQ 125
           +++N      H+   H+  + ++ W+P   G       L+LA  S D  + L        
Sbjct: 379 KQDNCV----HDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRL-------- 426

Query: 126 WEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEE 183
           W+V +    HT+        P     S+   P G      +  ASG  D  + +W  +
Sbjct: 427 WDVDRGICIHTL---TKHQEPVY---SVAFSPDG------RYLASGSFDKCVHIWNTQ 472



 Score = 43.1 bits (100), Expect = 3e-04
 Identities = 69/291 (23%), Positives = 113/291 (38%), Gaps = 56/291 (19%)

Query: 15  ATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWRE 74
           +T  S + V    +R GGQ    D+  ++  V  + W     G +LA+ SYD    IW +
Sbjct: 202 STSGSTQLVLRHCIREGGQ----DVPSNKD-VTSLDWNSE--GTLLATGSYDGFARIWTK 254

Query: 75  ENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNA 134
           +        +H G    + ++ W       IL+ G     I    +TGE + +       
Sbjct: 255 DGNLASTLGQHKG---PIFALKWNKKG-NFILSAGVDKTTIIWDAHTGEAKQQFP----F 306

Query: 135 HTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKL 194
           H+     V W               Q  N     ++  C ++ KL      GQ +  +  
Sbjct: 307 HSAPALDVDW---------------QSNNTFASCSTDMCIHVCKL------GQDRPIKTF 345

Query: 195 EAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHV 254
           + H++ V  + W P+  L    +ASCS D  + IW+    +        L   N  ++ +
Sbjct: 346 QGHTNEVNAIKWDPTGNL----LASCSDDMTLKIWSMKQDN----CVHDLQAHNKEIYTI 397

Query: 255 SWSIT--------ANILAVSGG-DNKVTLWKESVDGQWVCISDVNKGQGSV 296
            WS T        AN++  S   D+ V LW   VD + +CI  + K Q  V
Sbjct: 398 KWSPTGPGTNNPNANLMLASASFDSTVRLW--DVD-RGICIHTLTKHQEPV 445


>gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]
          Length = 1336

 Score = 52.8 bits (125), Expect = 4e-07
 Identities = 52/200 (26%), Positives = 83/200 (41%), Gaps = 28/200 (14%)

Query: 2   IHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILA 61
           + + +++  G  L T S D   K+FD+RN  + L    RGH+     VAW HP++  + A
Sbjct: 291 VMEVKLNLNGNWLLTASRDHLCKLFDIRNLKEELQV-FRGHKKEATAVAW-HPVHEGLFA 348

Query: 62  SCSYDRKVIIW----REENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISL 117
           S   D  ++ W     +E G  E +HE       + S+ W  H  G IL  GS+D     
Sbjct: 349 SGGSDGSLLFWHVGVEKEVGGMEMAHE-----GMIWSLAW--HPLGHILCSGSNDHTSKF 401

Query: 118 LTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLID--HPSGQKPNYIKRFASGGCDN 175
            T    G     K+ + + +          ++PG   D       +PN +      G   
Sbjct: 402 WTRNRPGD----KMRDRYNLN---------LLPGMSEDGVEYDDLEPNSLAVIPGMGIPE 448

Query: 176 LIKLWKEEEDGQWKEEQKLE 195
            +KL  E+E     E  ++E
Sbjct: 449 QLKLAMEQEQMGKDESNEIE 468



 Score = 39.7 bits (91), Expect = 0.003
 Identities = 58/227 (25%), Positives = 77/227 (33%), Gaps = 65/227 (28%)

Query: 2   IHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILA 61
           I +A       + ATCS D +V+I+D     +  I  LRGH   V  V W HP  G +++
Sbjct: 205 IREASFSPTDNKFATCSDDGTVRIWDFLRCHEERI--LRGHGADVKCVDW-HPTKGLVVS 261

Query: 62  SCSYDRKVI-IWREE----------------------NGTW------------------- 79
                ++ I  W  +                      NG W                   
Sbjct: 262 GSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFDIRNLK 321

Query: 80  EKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGC 139
           E+     GH     +V W P   GL  A G SDG  SLL +    + EV  +  AH    
Sbjct: 322 EELQVFRGHKKEATAVAWHPVHEGL-FASGGSDG--SLLFWHVGVEKEVGGMEMAH---- 374

Query: 140 NAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDG 186
             + W       SL  HP G          SG  D+  K W     G
Sbjct: 375 EGMIW-------SLAWHPLGH------ILCSGSNDHTSKFWTRNRPG 408



 Score = 34.7 bits (78), Expect = 0.11
 Identities = 51/228 (22%), Positives = 85/228 (37%), Gaps = 38/228 (16%)

Query: 58  NILASCSYDRKVIIWREENGTWEKSHEHA---GHDSSVNSVCWAPHDYGLILACGSSDGA 114
           N  A+CS D  V IW      + + HE     GH + V  V W P   GL+++ GS D  
Sbjct: 215 NKFATCSDDGTVRIW-----DFLRCHEERILRGHGADVKCVDWHPTK-GLVVS-GSKDSQ 267

Query: 115 ISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCD 174
             +        W+ K   +  T+  +           ++++       N++    +   D
Sbjct: 268 QPIKF------WDPKTGQSLATLHAHK---------NTVMEVKLNLNGNWL---LTASRD 309

Query: 175 NLIKLWKEEEDGQWKEE-QKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDD 233
           +L KL+   +    KEE Q    H      VAW P   +     AS   DG +  W    
Sbjct: 310 HLCKLF---DIRNLKEELQVFRGHKKEATAVAWHP---VHEGLFASGGSDGSLLFWHVG- 362

Query: 234 ASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDG 281
                   ++ H+   ++W ++W    +IL     D+    W  +  G
Sbjct: 363 VEKEVGGMEMAHE--GMIWSLAWHPLGHILCSGSNDHTSKFWTRNRPG 408


>gi|89026256 PREDICTED: similar to actin related protein 2/3 complex
           subunit 1B [Homo sapiens]
          Length = 370

 Score = 52.4 bits (124), Expect = 5e-07
 Identities = 31/119 (26%), Positives = 53/119 (44%), Gaps = 4/119 (3%)

Query: 12  TRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVII 71
           T++A C ++  V I++        + +L+ H G V  + WA     N + +C  DR   +
Sbjct: 19  TQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPE--SNRIVTCGTDRNAYV 76

Query: 72  WREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKK 130
           W  +  TW+ +      + +   V WAP++     A GS    IS+  +  E  W V K
Sbjct: 77  WTLKGRTWKPTLVILRINRAARCVRWAPNENK--FAVGSGSRVISICYFEQENDWWVCK 133



 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 28/106 (26%), Positives = 48/106 (45%), Gaps = 9/106 (8%)

Query: 182 EEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSP 241
           E+   +W +  +L+ H+  V  + WAP     ++ I +C  D   ++WT       TW P
Sbjct: 34  EKSGAKWTKVHELKEHNGQVTGIDWAPE----SNRIVTCGTDRNAYVWT---LKGRTWKP 86

Query: 242 KL-LHKFNDVVWHVSWSITANILAVSGGDNKVTL-WKESVDGQWVC 285
            L + + N     V W+   N  AV  G   +++ + E  +  WVC
Sbjct: 87  TLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQENDWWVC 132



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 32/131 (24%), Positives = 51/131 (38%), Gaps = 24/131 (18%)

Query: 60  LASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAI--SL 117
           +A C  + +V I+ +    W K HE   H+  V  + WAP +   I+ CG+   A   +L
Sbjct: 21  IAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAP-ESNRIVTCGTDRNAYVWTL 79

Query: 118 LTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLI 177
              T +    + +IN A       V WAP                    +FA G    +I
Sbjct: 80  KGRTWKPTLVILRINRA----ARCVRWAPNE-----------------NKFAVGSGSRVI 118

Query: 178 KLWKEEEDGQW 188
            +   E++  W
Sbjct: 119 SICYFEQENDW 129


>gi|5031601 actin related protein 2/3 complex subunit 1B [Homo
           sapiens]
          Length = 372

 Score = 52.4 bits (124), Expect = 5e-07
 Identities = 31/119 (26%), Positives = 53/119 (44%), Gaps = 4/119 (3%)

Query: 12  TRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVII 71
           T++A C ++  V I++        + +L+ H G V  + WA     N + +C  DR   +
Sbjct: 21  TQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPE--SNRIVTCGTDRNAYV 78

Query: 72  WREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKK 130
           W  +  TW+ +      + +   V WAP++     A GS    IS+  +  E  W V K
Sbjct: 79  WTLKGRTWKPTLVILRINRAARCVRWAPNENK--FAVGSGSRVISICYFEQENDWWVCK 135



 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 28/106 (26%), Positives = 48/106 (45%), Gaps = 9/106 (8%)

Query: 182 EEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSP 241
           E+   +W +  +L+ H+  V  + WAP     ++ I +C  D   ++WT       TW P
Sbjct: 36  EKSGAKWTKVHELKEHNGQVTGIDWAPE----SNRIVTCGTDRNAYVWT---LKGRTWKP 88

Query: 242 KL-LHKFNDVVWHVSWSITANILAVSGGDNKVTL-WKESVDGQWVC 285
            L + + N     V W+   N  AV  G   +++ + E  +  WVC
Sbjct: 89  TLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQENDWWVC 134



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 32/131 (24%), Positives = 51/131 (38%), Gaps = 24/131 (18%)

Query: 60  LASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAI--SL 117
           +A C  + +V I+ +    W K HE   H+  V  + WAP +   I+ CG+   A   +L
Sbjct: 23  IAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAP-ESNRIVTCGTDRNAYVWTL 81

Query: 118 LTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLI 177
              T +    + +IN A       V WAP                    +FA G    +I
Sbjct: 82  KGRTWKPTLVILRINRA----ARCVRWAPNE-----------------NKFAVGSGSRVI 120

Query: 178 KLWKEEEDGQW 188
            +   E++  W
Sbjct: 121 SICYFEQENDW 131


>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score = 52.0 bits (123), Expect = 7e-07
 Identities = 74/265 (27%), Positives = 103/265 (38%), Gaps = 56/265 (21%)

Query: 39  LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR-EENGTWEKSH-------EHAGHD- 89
           LRGHE  V+  AW +P+  ++LAS S D    IW   EN     +           GHD 
Sbjct: 177 LRGHESEVFICAW-NPV-SDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 234

Query: 90  ---SSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAP 146
                V S+ W  +  G +LA GS DG   + T  G         N A T+G +      
Sbjct: 235 PSNKDVTSLDW--NTNGTLLATGSYDGFARIWTEDG---------NLASTLGQH------ 277

Query: 147 AVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAW 206
               G +      +K NYI    S G D    +W +   G+ K  Q+   HS    DV W
Sbjct: 278 ---KGPIFALKWNRKGNYI---LSAGVDKTTIIW-DAHTGEAK--QQFPFHSAPALDVDW 328

Query: 207 APSIGLPTSTIASCSQDGRVFIWT--CDDASSNTWSPKLLHKFNDVVWHVSWSITANILA 264
             +     +T ASCS D  + +    CD         K      + V  + W  +  +LA
Sbjct: 329 QNN-----TTFASCSTDMCIHVCRLGCDR------PVKTFQGHTNEVNAIKWDPSGMLLA 377

Query: 265 VSGGDNKVTLWKESVDGQWVCISDV 289
               D  + +W      Q VCI D+
Sbjct: 378 SCSDDMTLKIWSMK---QEVCIHDL 399



 Score = 49.3 bits (116), Expect = 4e-06
 Identities = 33/105 (31%), Positives = 56/105 (53%), Gaps = 9/105 (8%)

Query: 14  LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR 73
           LA+ S D +V+++D+  G  +    L  H+ PV+ VA++    G  LAS S+D+ V IW 
Sbjct: 427 LASASFDSTVRLWDIERG--VCTHTLTKHQEPVYSVAFSPD--GKYLASGSFDKCVHIWN 482

Query: 74  EENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLL 118
            ++G    S+   G    +  VCW  +  G  +   +SDG++ +L
Sbjct: 483 TQSGNLVHSYRGTG---GIFEVCW--NARGDKVGASASDGSVCVL 522



 Score = 38.9 bits (89), Expect = 0.006
 Identities = 73/318 (22%), Positives = 116/318 (36%), Gaps = 88/318 (27%)

Query: 14  LATCSSDRSVKIFDVR---NGGQILIADLR------GHEGP----VWQVAWAHPMYGNIL 60
           LA+ S D + +I+++    NGG   +  LR      GH+ P    V  + W     G +L
Sbjct: 196 LASGSGDSTARIWNLNENSNGGSTQLV-LRHCIREGGHDVPSNKDVTSLDWN--TNGTLL 252

Query: 61  ASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY 120
           A+ SYD    IW E+        +H G    + ++ W       IL+ G     I    +
Sbjct: 253 ATGSYDGFARIWTEDGNLASTLGQHKG---PIFALKW-NRKGNYILSAGVDKTTIIWDAH 308

Query: 121 TGEGQ--------------WEVK-----------------------KINNAHTIGCNAVS 143
           TGE +              W+                         K    HT   NA+ 
Sbjct: 309 TGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIK 368

Query: 144 WAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRD 203
           W P+   G L+              AS   D  +K+W  +++    +   L+AH+  +  
Sbjct: 369 WDPS---GMLL--------------ASCSDDMTLKIWSMKQEVCIHD---LQAHNKEIYT 408

Query: 204 VAWAPSIGLPTST------IASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWS 257
           + W+P+ G  TS       +AS S D  V +W  +           L K  + V+ V++S
Sbjct: 409 IKWSPT-GPATSNPNSNIMLASASFDSTVRLWDIERGVCT----HTLTKHQEPVYSVAFS 463

Query: 258 ITANILAVSGGDNKVTLW 275
                LA    D  V +W
Sbjct: 464 PDGKYLASGSFDKCVHIW 481


>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score = 52.0 bits (123), Expect = 7e-07
 Identities = 74/265 (27%), Positives = 103/265 (38%), Gaps = 56/265 (21%)

Query: 39  LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR-EENGTWEKSH-------EHAGHD- 89
           LRGHE  V+  AW +P+  ++LAS S D    IW   EN     +           GHD 
Sbjct: 177 LRGHESEVFICAW-NPV-SDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 234

Query: 90  ---SSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAP 146
                V S+ W  +  G +LA GS DG   + T  G         N A T+G +      
Sbjct: 235 PSNKDVTSLDW--NTNGTLLATGSYDGFARIWTEDG---------NLASTLGQH------ 277

Query: 147 AVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAW 206
               G +      +K NYI    S G D    +W +   G+ K  Q+   HS    DV W
Sbjct: 278 ---KGPIFALKWNRKGNYI---LSAGVDKTTIIW-DAHTGEAK--QQFPFHSAPALDVDW 328

Query: 207 APSIGLPTSTIASCSQDGRVFIWT--CDDASSNTWSPKLLHKFNDVVWHVSWSITANILA 264
             +     +T ASCS D  + +    CD         K      + V  + W  +  +LA
Sbjct: 329 QNN-----TTFASCSTDMCIHVCRLGCDR------PVKTFQGHTNEVNAIKWDPSGMLLA 377

Query: 265 VSGGDNKVTLWKESVDGQWVCISDV 289
               D  + +W      Q VCI D+
Sbjct: 378 SCSDDMTLKIWSMK---QEVCIHDL 399



 Score = 49.3 bits (116), Expect = 4e-06
 Identities = 33/105 (31%), Positives = 56/105 (53%), Gaps = 9/105 (8%)

Query: 14  LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR 73
           LA+ S D +V+++D+  G  +    L  H+ PV+ VA++    G  LAS S+D+ V IW 
Sbjct: 427 LASASFDSTVRLWDIERG--VCTHTLTKHQEPVYSVAFSPD--GKYLASGSFDKCVHIWN 482

Query: 74  EENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLL 118
            ++G    S+   G    +  VCW  +  G  +   +SDG++ +L
Sbjct: 483 TQSGNLVHSYRGTG---GIFEVCW--NARGDKVGASASDGSVCVL 522



 Score = 38.9 bits (89), Expect = 0.006
 Identities = 73/318 (22%), Positives = 116/318 (36%), Gaps = 88/318 (27%)

Query: 14  LATCSSDRSVKIFDVR---NGGQILIADLR------GHEGP----VWQVAWAHPMYGNIL 60
           LA+ S D + +I+++    NGG   +  LR      GH+ P    V  + W     G +L
Sbjct: 196 LASGSGDSTARIWNLNENSNGGSTQLV-LRHCIREGGHDVPSNKDVTSLDWN--TNGTLL 252

Query: 61  ASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY 120
           A+ SYD    IW E+        +H G    + ++ W       IL+ G     I    +
Sbjct: 253 ATGSYDGFARIWTEDGNLASTLGQHKG---PIFALKW-NRKGNYILSAGVDKTTIIWDAH 308

Query: 121 TGEGQ--------------WEVK-----------------------KINNAHTIGCNAVS 143
           TGE +              W+                         K    HT   NA+ 
Sbjct: 309 TGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIK 368

Query: 144 WAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRD 203
           W P+   G L+              AS   D  +K+W  +++    +   L+AH+  +  
Sbjct: 369 WDPS---GMLL--------------ASCSDDMTLKIWSMKQEVCIHD---LQAHNKEIYT 408

Query: 204 VAWAPSIGLPTST------IASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWS 257
           + W+P+ G  TS       +AS S D  V +W  +           L K  + V+ V++S
Sbjct: 409 IKWSPT-GPATSNPNSNIMLASASFDSTVRLWDIERGVCT----HTLTKHQEPVYSVAFS 463

Query: 258 ITANILAVSGGDNKVTLW 275
                LA    D  V +W
Sbjct: 464 PDGKYLASGSFDKCVHIW 481


>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score = 52.0 bits (123), Expect = 7e-07
 Identities = 74/265 (27%), Positives = 103/265 (38%), Gaps = 56/265 (21%)

Query: 39  LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR-EENGTWEKSH-------EHAGHD- 89
           LRGHE  V+  AW +P+  ++LAS S D    IW   EN     +           GHD 
Sbjct: 228 LRGHESEVFICAW-NPV-SDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 285

Query: 90  ---SSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAP 146
                V S+ W  +  G +LA GS DG   + T  G         N A T+G +      
Sbjct: 286 PSNKDVTSLDW--NTNGTLLATGSYDGFARIWTEDG---------NLASTLGQH------ 328

Query: 147 AVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAW 206
               G +      +K NYI    S G D    +W +   G+ K  Q+   HS    DV W
Sbjct: 329 ---KGPIFALKWNRKGNYI---LSAGVDKTTIIW-DAHTGEAK--QQFPFHSAPALDVDW 379

Query: 207 APSIGLPTSTIASCSQDGRVFIWT--CDDASSNTWSPKLLHKFNDVVWHVSWSITANILA 264
             +     +T ASCS D  + +    CD         K      + V  + W  +  +LA
Sbjct: 380 QNN-----TTFASCSTDMCIHVCRLGCDR------PVKTFQGHTNEVNAIKWDPSGMLLA 428

Query: 265 VSGGDNKVTLWKESVDGQWVCISDV 289
               D  + +W      Q VCI D+
Sbjct: 429 SCSDDMTLKIWSMK---QEVCIHDL 450



 Score = 49.3 bits (116), Expect = 4e-06
 Identities = 33/105 (31%), Positives = 56/105 (53%), Gaps = 9/105 (8%)

Query: 14  LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR 73
           LA+ S D +V+++D+  G  +    L  H+ PV+ VA++    G  LAS S+D+ V IW 
Sbjct: 478 LASASFDSTVRLWDIERG--VCTHTLTKHQEPVYSVAFSPD--GKYLASGSFDKCVHIWN 533

Query: 74  EENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLL 118
            ++G    S+   G    +  VCW  +  G  +   +SDG++ +L
Sbjct: 534 TQSGNLVHSYRGTG---GIFEVCW--NARGDKVGASASDGSVCVL 573



 Score = 38.9 bits (89), Expect = 0.006
 Identities = 73/318 (22%), Positives = 116/318 (36%), Gaps = 88/318 (27%)

Query: 14  LATCSSDRSVKIFDVR---NGGQILIADLR------GHEGP----VWQVAWAHPMYGNIL 60
           LA+ S D + +I+++    NGG   +  LR      GH+ P    V  + W     G +L
Sbjct: 247 LASGSGDSTARIWNLNENSNGGSTQLV-LRHCIREGGHDVPSNKDVTSLDWN--TNGTLL 303

Query: 61  ASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY 120
           A+ SYD    IW E+        +H G    + ++ W       IL+ G     I    +
Sbjct: 304 ATGSYDGFARIWTEDGNLASTLGQHKG---PIFALKW-NRKGNYILSAGVDKTTIIWDAH 359

Query: 121 TGEGQ--------------WEVK-----------------------KINNAHTIGCNAVS 143
           TGE +              W+                         K    HT   NA+ 
Sbjct: 360 TGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIK 419

Query: 144 WAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRD 203
           W P+   G L+              AS   D  +K+W  +++    +   L+AH+  +  
Sbjct: 420 WDPS---GMLL--------------ASCSDDMTLKIWSMKQEVCIHD---LQAHNKEIYT 459

Query: 204 VAWAPSIGLPTST------IASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWS 257
           + W+P+ G  TS       +AS S D  V +W  +           L K  + V+ V++S
Sbjct: 460 IKWSPT-GPATSNPNSNIMLASASFDSTVRLWDIERGVCT----HTLTKHQEPVYSVAFS 514

Query: 258 ITANILAVSGGDNKVTLW 275
                LA    D  V +W
Sbjct: 515 PDGKYLASGSFDKCVHIW 532


>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score = 52.0 bits (123), Expect = 7e-07
 Identities = 74/265 (27%), Positives = 103/265 (38%), Gaps = 56/265 (21%)

Query: 39  LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR-EENGTWEKSH-------EHAGHD- 89
           LRGHE  V+  AW +P+  ++LAS S D    IW   EN     +           GHD 
Sbjct: 228 LRGHESEVFICAW-NPV-SDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 285

Query: 90  ---SSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAP 146
                V S+ W  +  G +LA GS DG   + T  G         N A T+G +      
Sbjct: 286 PSNKDVTSLDW--NTNGTLLATGSYDGFARIWTEDG---------NLASTLGQH------ 328

Query: 147 AVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAW 206
               G +      +K NYI    S G D    +W +   G+ K  Q+   HS    DV W
Sbjct: 329 ---KGPIFALKWNRKGNYI---LSAGVDKTTIIW-DAHTGEAK--QQFPFHSAPALDVDW 379

Query: 207 APSIGLPTSTIASCSQDGRVFIWT--CDDASSNTWSPKLLHKFNDVVWHVSWSITANILA 264
             +     +T ASCS D  + +    CD         K      + V  + W  +  +LA
Sbjct: 380 QNN-----TTFASCSTDMCIHVCRLGCDR------PVKTFQGHTNEVNAIKWDPSGMLLA 428

Query: 265 VSGGDNKVTLWKESVDGQWVCISDV 289
               D  + +W      Q VCI D+
Sbjct: 429 SCSDDMTLKIWSMK---QEVCIHDL 450



 Score = 49.3 bits (116), Expect = 4e-06
 Identities = 33/105 (31%), Positives = 56/105 (53%), Gaps = 9/105 (8%)

Query: 14  LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR 73
           LA+ S D +V+++D+  G  +    L  H+ PV+ VA++    G  LAS S+D+ V IW 
Sbjct: 478 LASASFDSTVRLWDIERG--VCTHTLTKHQEPVYSVAFSPD--GKYLASGSFDKCVHIWN 533

Query: 74  EENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLL 118
            ++G    S+   G    +  VCW  +  G  +   +SDG++ +L
Sbjct: 534 TQSGNLVHSYRGTG---GIFEVCW--NARGDKVGASASDGSVCVL 573



 Score = 38.9 bits (89), Expect = 0.006
 Identities = 73/318 (22%), Positives = 116/318 (36%), Gaps = 88/318 (27%)

Query: 14  LATCSSDRSVKIFDVR---NGGQILIADLR------GHEGP----VWQVAWAHPMYGNIL 60
           LA+ S D + +I+++    NGG   +  LR      GH+ P    V  + W     G +L
Sbjct: 247 LASGSGDSTARIWNLNENSNGGSTQLV-LRHCIREGGHDVPSNKDVTSLDWN--TNGTLL 303

Query: 61  ASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY 120
           A+ SYD    IW E+        +H G    + ++ W       IL+ G     I    +
Sbjct: 304 ATGSYDGFARIWTEDGNLASTLGQHKG---PIFALKW-NRKGNYILSAGVDKTTIIWDAH 359

Query: 121 TGEGQ--------------WEVK-----------------------KINNAHTIGCNAVS 143
           TGE +              W+                         K    HT   NA+ 
Sbjct: 360 TGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIK 419

Query: 144 WAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRD 203
           W P+   G L+              AS   D  +K+W  +++    +   L+AH+  +  
Sbjct: 420 WDPS---GMLL--------------ASCSDDMTLKIWSMKQEVCIHD---LQAHNKEIYT 459

Query: 204 VAWAPSIGLPTST------IASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWS 257
           + W+P+ G  TS       +AS S D  V +W  +           L K  + V+ V++S
Sbjct: 460 IKWSPT-GPATSNPNSNIMLASASFDSTVRLWDIERGVCT----HTLTKHQEPVYSVAFS 514

Query: 258 ITANILAVSGGDNKVTLW 275
                LA    D  V +W
Sbjct: 515 PDGKYLASGSFDKCVHIW 532


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.131    0.435 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,785,675
Number of Sequences: 37866
Number of extensions: 643257
Number of successful extensions: 2569
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 26
Number of HSP's successfully gapped in prelim test: 186
Number of HSP's that attempted gapping in prelim test: 1813
Number of HSP's gapped (non-prelim): 625
length of query: 308
length of database: 18,247,518
effective HSP length: 102
effective length of query: 206
effective length of database: 14,385,186
effective search space: 2963348316
effective search space used: 2963348316
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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