BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|210032390 SEC13 protein isoform 2 [Homo sapiens] (308 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|210032390 SEC13 protein isoform 2 [Homo sapiens] 659 0.0 gi|34335134 SEC13 protein isoform 1 [Homo sapiens] 659 0.0 gi|61743971 sec13-like protein isoform 1 [Homo sapiens] 151 8e-37 gi|61743969 sec13-like protein isoform 2 [Homo sapiens] 151 8e-37 gi|4757988 WD repeat domain 39 [Homo sapiens] 103 1e-22 gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 68 1e-11 gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 64 1e-10 gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 64 2e-10 gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 64 2e-10 gi|19913367 transducin beta-like 1Y [Homo sapiens] 63 4e-10 gi|19913365 transducin beta-like 1Y [Homo sapiens] 63 4e-10 gi|15150805 transducin beta-like 1Y [Homo sapiens] 63 4e-10 gi|32483359 apoptotic peptidase activating factor 1 isoform c [H... 60 2e-09 gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho... 60 2e-09 gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 59 4e-09 gi|19913369 transducin beta-like 3 [Homo sapiens] 58 9e-09 gi|4506439 retinoblastoma binding protein 7 [Homo sapiens] 58 1e-08 gi|23199987 WD repeat domain 5B [Homo sapiens] 55 8e-08 gi|14150171 THO complex 3 [Homo sapiens] 54 2e-07 gi|237820620 glutamate-rich WD repeat containing 1 [Homo sapiens] 53 4e-07 gi|223029510 echinoderm microtubule associated protein like 4 is... 53 4e-07 gi|19923497 echinoderm microtubule associated protein like 4 iso... 53 4e-07 gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 53 4e-07 gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens] 53 4e-07 gi|89026256 PREDICTED: similar to actin related protein 2/3 comp... 52 5e-07 gi|5031601 actin related protein 2/3 complex subunit 1B [Homo sa... 52 5e-07 gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 52 7e-07 gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 52 7e-07 gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 52 7e-07 gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] 52 7e-07 >gi|210032390 SEC13 protein isoform 2 [Homo sapiens] Length = 308 Score = 659 bits (1699), Expect = 0.0 Identities = 308/308 (100%), Positives = 308/308 (100%) Query: 1 MIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNIL 60 MIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNIL Sbjct: 1 MIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNIL 60 Query: 61 ASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY 120 ASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY Sbjct: 61 ASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY 120 Query: 121 TGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLW 180 TGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLW Sbjct: 121 TGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLW 180 Query: 181 KEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWS 240 KEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWS Sbjct: 181 KEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWS 240 Query: 241 PKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVSASV 300 PKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVSASV Sbjct: 241 PKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVSASV 300 Query: 301 TEGQQNEQ 308 TEGQQNEQ Sbjct: 301 TEGQQNEQ 308 >gi|34335134 SEC13 protein isoform 1 [Homo sapiens] Length = 322 Score = 659 bits (1699), Expect = 0.0 Identities = 308/308 (100%), Positives = 308/308 (100%) Query: 1 MIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNIL 60 MIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNIL Sbjct: 15 MIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNIL 74 Query: 61 ASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY 120 ASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY Sbjct: 75 ASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY 134 Query: 121 TGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLW 180 TGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLW Sbjct: 135 TGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLW 194 Query: 181 KEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWS 240 KEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWS Sbjct: 195 KEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWS 254 Query: 241 PKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVSASV 300 PKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVSASV Sbjct: 255 PKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVSASV 314 Query: 301 TEGQQNEQ 308 TEGQQNEQ Sbjct: 315 TEGQQNEQ 322 >gi|61743971 sec13-like protein isoform 1 [Homo sapiens] Length = 421 Score = 151 bits (381), Expect = 8e-37 Identities = 103/338 (30%), Positives = 156/338 (46%), Gaps = 47/338 (13%) Query: 1 MIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQI-LIADLRGHEGPVWQVAWAHPMYGNI 59 +IHD D++G R+ATCSSD+SVK++D G A + H G VW+V WAHP +G + Sbjct: 14 LIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEFGQV 73 Query: 60 LASCSYDRKVIIWREENGT----------WEKSHEHAGHDSSVNSVCWAPHDYGLILACG 109 LASCS+DR +W E G W K +SV V +AP GL+LA Sbjct: 74 LASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATC 133 Query: 110 SSDGAISLL---TYTGEGQWEVKKINNAHTIGCNAVSW--------APAVVPGSLIDHPS 158 S+DG + + QW ++ + + C+ +SW +P + GS P+ Sbjct: 134 SADGIVRIYEAPDVMNLSQWSLQH-EISCKLSCSCISWNPSSSRAHSPMIAVGSDDSSPN 192 Query: 159 GQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIA 218 I + E ++ + + L +D V D+A+AP++G +A Sbjct: 193 AMAKVQIFEY-------------NENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILA 239 Query: 219 SCSQDGRVFIW------TCDDASSNTWSPKLLHKF---NDVVWHVSWSITANILAVSGGD 269 ++D R+F + ++ +F N VW VSW+IT +LA SG D Sbjct: 240 IATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDD 299 Query: 270 NKVTLWKESVDGQWVCISDVNKGQGS-VSASVTEGQQN 306 V LWK + W C + + KG GS V+ S +G N Sbjct: 300 GCVRLWKANYMDNWKC-TGILKGNGSPVNGSSQQGTSN 336 Score = 31.6 bits (70), Expect = 0.93 Identities = 14/48 (29%), Positives = 21/48 (43%) Query: 249 DVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSV 296 D++ VS+ +A D V +W +S G W C + GSV Sbjct: 13 DLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSV 60 >gi|61743969 sec13-like protein isoform 2 [Homo sapiens] Length = 360 Score = 151 bits (381), Expect = 8e-37 Identities = 103/338 (30%), Positives = 156/338 (46%), Gaps = 47/338 (13%) Query: 1 MIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQI-LIADLRGHEGPVWQVAWAHPMYGNI 59 +IHD D++G R+ATCSSD+SVK++D G A + H G VW+V WAHP +G + Sbjct: 14 LIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEFGQV 73 Query: 60 LASCSYDRKVIIWREENGT----------WEKSHEHAGHDSSVNSVCWAPHDYGLILACG 109 LASCS+DR +W E G W K +SV V +AP GL+LA Sbjct: 74 LASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATC 133 Query: 110 SSDGAISLL---TYTGEGQWEVKKINNAHTIGCNAVSW--------APAVVPGSLIDHPS 158 S+DG + + QW ++ + + C+ +SW +P + GS P+ Sbjct: 134 SADGIVRIYEAPDVMNLSQWSLQH-EISCKLSCSCISWNPSSSRAHSPMIAVGSDDSSPN 192 Query: 159 GQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIA 218 I + E ++ + + L +D V D+A+AP++G +A Sbjct: 193 AMAKVQIFEY-------------NENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILA 239 Query: 219 SCSQDGRVFIW------TCDDASSNTWSPKLLHKF---NDVVWHVSWSITANILAVSGGD 269 ++D R+F + ++ +F N VW VSW+IT +LA SG D Sbjct: 240 IATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDD 299 Query: 270 NKVTLWKESVDGQWVCISDVNKGQGS-VSASVTEGQQN 306 V LWK + W C + + KG GS V+ S +G N Sbjct: 300 GCVRLWKANYMDNWKC-TGILKGNGSPVNGSSQQGTSN 336 Score = 31.6 bits (70), Expect = 0.93 Identities = 14/48 (29%), Positives = 21/48 (43%) Query: 249 DVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSV 296 D++ VS+ +A D V +W +S G W C + GSV Sbjct: 13 DLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSV 60 >gi|4757988 WD repeat domain 39 [Homo sapiens] Length = 339 Score = 103 bits (258), Expect = 1e-22 Identities = 83/280 (29%), Positives = 126/280 (45%), Gaps = 39/280 (13%) Query: 11 GTRLATCSSDRSVKIFDVRNGGQILIADL-RGHEGPVWQVAWAHPMYGNILASCSYDRKV 69 GT LA+C DR ++I+ I + L GH+ V +VAW+ GN LAS S+D Sbjct: 28 GTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSP--CGNYLASASFDATT 85 Query: 70 IIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVK 129 IW++ +E GH++ V SV WAP G +LA S D ++ + E ++E Sbjct: 86 CIWKKNQDDFECVTTLEGHENEVKSVAWAPS--GNLLATCSRDKSVWVWEVDEEDEYECV 143 Query: 130 KINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWK 189 + N+HT V W HPS + AS D+ +KL++EEED W Sbjct: 144 SVLNSHTQDVKHVVW-----------HPSQE------LLASASYDDTVKLYREEED-DWV 185 Query: 190 EEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIW-----------TCDDASSNT 238 LE H V +A+ PS +ASCS D V IW C + + Sbjct: 186 CCATLEGHESTVWSLAFDPS----GQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSW 241 Query: 239 WSPKLLHKFND-VVWHVSWSITANILAVSGGDNKVTLWKE 277 L F+ ++ ++W LA + GD+ + +++E Sbjct: 242 KCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQE 281 Score = 75.1 bits (183), Expect = 7e-14 Identities = 66/251 (26%), Positives = 113/251 (45%), Gaps = 32/251 (12%) Query: 34 ILIADLRGH-EGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWE-KSHEHAGHDSS 91 +L+ + H + W +AW +P G +LASC DR++ IW E +W KS GH + Sbjct: 6 VLLGRVPAHPDSRCWFLAW-NPA-GTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRT 63 Query: 92 VNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPG 151 V V W+P G LA S D A + + + +E H +V+WAP+ G Sbjct: 64 VRKVAWSP--CGNYLASASFD-ATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPS---G 117 Query: 152 SLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIG 211 +L+ A+ D + +W+ +E+ +++ L +H+ V+ V W PS Sbjct: 118 NLL--------------ATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQE 163 Query: 212 LPTSTIASCSQDGRVFIWTCDDASSNTW-SPKLLHKFNDVVWHVSWSITANILAVSGGDN 270 L +AS S D V ++ ++ + W L VW +++ + LA D Sbjct: 164 L----LASASYDDTVKLYREEE---DDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDR 216 Query: 271 KVTLWKESVDG 281 V +W++ + G Sbjct: 217 TVRIWRQYLPG 227 Score = 64.7 bits (156), Expect = 1e-10 Identities = 69/237 (29%), Positives = 99/237 (41%), Gaps = 40/237 (16%) Query: 11 GTRLATCSSDRSVKIFDVRNGGQI-LIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKV 69 G LATCS D+SV +++V + ++ L H V V W HP +LAS SYD V Sbjct: 117 GNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVW-HPSQ-ELLASASYDDTV 174 Query: 70 IIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVK 129 ++REE W GH+S+V S+ + P G LA S D + + W Sbjct: 175 KLYREEEDDWVCCATLEGHESTVWSLAFDPS--GQRLASCSDDRTVRI--------WRQY 224 Query: 130 KINNAHTIGCNAV--SWAPAVVPGSLIDHPSGQKPNYIKRFA--------SGGC-DNLIK 178 N + C+ SW I SG I A + C D+ I+ Sbjct: 225 LPGNEQGVACSGSDPSW-------KCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIR 277 Query: 179 LWKEEEDGQWKEE------QKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIW 229 +++E+ + ++ +AHS V VAW P +ASCS DG V W Sbjct: 278 VFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPK---EPGLLASCSDDGEVAFW 331 Score = 52.8 bits (125), Expect = 4e-07 Identities = 38/124 (30%), Positives = 56/124 (45%), Gaps = 10/124 (8%) Query: 169 ASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFI 228 AS G D I++W E D + E H VR VAW+P + +AS S D I Sbjct: 32 ASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPC----GNYLASASFDATTCI 87 Query: 229 W--TCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCI 286 W DD T L + V V+W+ + N+LA D V +W+ + ++ C+ Sbjct: 88 WKKNQDDFECVT----TLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECV 143 Query: 287 SDVN 290 S +N Sbjct: 144 SVLN 147 Score = 50.4 bits (119), Expect = 2e-06 Identities = 37/133 (27%), Positives = 57/133 (42%), Gaps = 22/133 (16%) Query: 8 DYYGTRLATCSSDRSVKIFDVRNGGQI-------------LIADLRG-HEGPVWQVAWAH 53 D G RLA+CS DR+V+I+ G I L G H ++ +AW Sbjct: 203 DPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQ 262 Query: 54 PMYGNILASCSYDRKVIIWREENGTWEK------SHEHAGHDSSVNSVCWAPHDYGLILA 107 + G + +C D + + N ++ +H H H VN V W P + GL+ + Sbjct: 263 -LTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLAS 321 Query: 108 CGSSDGAISLLTY 120 C S DG ++ Y Sbjct: 322 C-SDDGEVAFWKY 333 Score = 35.8 bits (81), Expect = 0.049 Identities = 13/41 (31%), Positives = 24/41 (58%), Gaps = 1/41 (2%) Query: 252 WHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKG 292 W ++W+ +LA GGD ++ +W D W+C S +++G Sbjct: 20 WFLAWNPAGTLLASCGGDRRIRIWGTEGD-SWICKSVLSEG 59 >gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit [Homo sapiens] Length = 410 Score = 67.8 bits (164), Expect = 1e-11 Identities = 71/279 (25%), Positives = 119/279 (42%), Gaps = 27/279 (9%) Query: 2 IHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILA 61 + D D+ G LA+CS+D ++K++D + G I + GH+ V VA G+ + Sbjct: 153 VQDISFDHSGKLLASCSADMTIKLWDFQ--GFECIRTMHGHDHNVSSVAIM--PNGDHIV 208 Query: 62 SCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISL-LTY 120 S S D+ + +W + G K+ GH V V P+ G ++A S+D + + + Sbjct: 209 SASRDKTIKMWEVQTGYCVKT--FTGHREWVRMV--RPNQDGTLIASCSNDQTVRVWVVA 264 Query: 121 TGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKR---FASGGCDNLI 177 T E + E+++ + H + C +SWAP S+ + + K SG D I Sbjct: 265 TKECKAELRE--HEHVVEC--ISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTI 320 Query: 178 KLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSN 237 K+W + G L H +WVR V + I SC+ D + +W N Sbjct: 321 KMW-DVSTGMCL--MTLVGHDNWVRGVLFHSG----GKFILSCADDKTLRVWD----YKN 369 Query: 238 TWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 276 K L+ V + + TA + D V +W+ Sbjct: 370 KRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408 Score = 54.3 bits (129), Expect = 1e-07 Identities = 60/228 (26%), Positives = 98/228 (42%), Gaps = 37/228 (16%) Query: 39 LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWA 98 L GH PV +V + HP++ +++ S S D + +W E G +E++ + GH SV + + Sbjct: 104 LSGHRSPVTRVIF-HPVF-SVMVSASEDATIKVWDYETGDFERTLK--GHTDSVQDISF- 158 Query: 99 PHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPS 158 G +LA S+D I L + G +E + + H ++V A++P DH Sbjct: 159 -DHSGKLLASCSADMTIKLWDFQG---FECIRTMHGHDHNVSSV----AIMPNG--DH-- 206 Query: 159 GQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIA 218 S D IK+W E + G + H +WVR V + IA Sbjct: 207 ---------IVSASRDKTIKMW-EVQTGYC--VKTFTGHREWVRMV----RPNQDGTLIA 250 Query: 219 SCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVS 266 SCS D V +W L + VV +SW+ ++ ++S Sbjct: 251 SCSNDQTVRVWVVATKECKA----ELREHEHVVECISWAPESSYSSIS 294 >gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] Length = 357 Score = 64.3 bits (155), Expect = 1e-10 Identities = 69/269 (25%), Positives = 109/269 (40%), Gaps = 38/269 (14%) Query: 11 GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVI 70 G+ LA+ DR + +++V G A L+GH G V ++ + G++L S S D+ V Sbjct: 78 GSTLASAGFDRLILLWNVY-GDCDNYATLKGHSGAVMELHYNTD--GSMLFSASTDKTVA 134 Query: 71 IWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKK 130 +W E G E+ GH S VNS C+ ++ GS DG + L W+++K Sbjct: 135 VWDSETG--ERVKRLKGHTSFVNS-CYPARRGPQLVCTGSDDGTVKL--------WDIRK 183 Query: 131 INNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKE 190 T AV D + SGG DN IK+W ++ K Sbjct: 184 KAAIQTF--QNTYQVLAVTFNDTSD-----------QIISGGIDNDIKVWDLRQN---KL 227 Query: 191 EQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKL----LHK 246 + H+D V + S+ S + S + D V +W + K+ +H Sbjct: 228 TYTMRGHADSVTGL----SLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHN 283 Query: 247 FNDVVWHVSWSITANILAVSGGDNKVTLW 275 F + SWS + +A D V +W Sbjct: 284 FEKNLLRCSWSPDGSKIAAGSADRFVYVW 312 >gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo sapiens] Length = 1205 Score = 63.9 bits (154), Expect = 2e-10 Identities = 66/282 (23%), Positives = 105/282 (37%), Gaps = 57/282 (20%) Query: 11 GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVI 70 G R+A+C +D+++++F G ++L +++ HE V A++ +A+CS D+KV Sbjct: 627 GQRIASCGADKTLQVFKAETGEKLL--EIKAHEDEVLCCAFSTD--DRFIATCSVDKKVK 682 Query: 71 IWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKK 130 IW G E H + H VN + + L+LA GSSD + L Q E + Sbjct: 683 IWNSMTG--ELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDL---NQKECRN 737 Query: 131 INNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKE 190 HT N ++P K AS D +KLW + K Sbjct: 738 TMFGHTNSVNHCRFSPD-----------------DKLLASCSADGTLKLWDATSANERKS 780 Query: 191 ----------EQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWS 240 E E V+ +W+ + ++F+W D S Sbjct: 781 INVKQFFLNLEDPQEDMEVIVKCCSWSAD-----GARIMVAAKNKIFLWNTDSRS----- 830 Query: 241 PKLLHKFNDVVWHVSW------SITANILAVSGGDNKVTLWK 276 K D H+SW S + S D + LW+ Sbjct: 831 -----KVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 867 >gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo sapiens] Length = 1194 Score = 63.9 bits (154), Expect = 2e-10 Identities = 66/282 (23%), Positives = 105/282 (37%), Gaps = 57/282 (20%) Query: 11 GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVI 70 G R+A+C +D+++++F G ++L +++ HE V A++ +A+CS D+KV Sbjct: 616 GQRIASCGADKTLQVFKAETGEKLL--EIKAHEDEVLCCAFSTD--DRFIATCSVDKKVK 671 Query: 71 IWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKK 130 IW G E H + H VN + + L+LA GSSD + L Q E + Sbjct: 672 IWNSMTG--ELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDL---NQKECRN 726 Query: 131 INNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKE 190 HT N ++P K AS D +KLW + K Sbjct: 727 TMFGHTNSVNHCRFSPD-----------------DKLLASCSADGTLKLWDATSANERKS 769 Query: 191 ----------EQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWS 240 E E V+ +W+ + ++F+W D S Sbjct: 770 INVKQFFLNLEDPQEDMEVIVKCCSWSAD-----GARIMVAAKNKIFLWNTDSRS----- 819 Query: 241 PKLLHKFNDVVWHVSW------SITANILAVSGGDNKVTLWK 276 K D H+SW S + S D + LW+ Sbjct: 820 -----KVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 856 >gi|19913367 transducin beta-like 1Y [Homo sapiens] Length = 522 Score = 62.8 bits (151), Expect = 4e-10 Identities = 74/308 (24%), Positives = 114/308 (37%), Gaps = 83/308 (26%) Query: 11 GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVI 70 GT LA S D +I+ NG L + L H+GP++ + W GN + S D+ I Sbjct: 247 GTLLAMGSYDGFARIW-TENGN--LASTLGQHKGPIFALKWNKK--GNYVLSAGVDKTTI 301 Query: 71 IWREENGT----------------WEKSHEHA-----------------------GHDSS 91 IW G W+ + A GH + Sbjct: 302 IWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNE 361 Query: 92 VNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNA-----VSWAP 146 VN++ W P G++LA S D + + W +K+ H + ++ + W+P Sbjct: 362 VNAIKWDPS--GMLLASCSDDMTLKI--------WSMKQDACVHDLQAHSKEIYTIKWSP 411 Query: 147 AVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAW 206 P+ PN AS D+ ++LW E Q L H + V VA+ Sbjct: 412 T--------GPATSNPNSSIMLASASFDSTVRLWDVE---QGVCTHTLMKHQEPVYSVAF 460 Query: 207 APSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDV--VWHVSWSITANILA 264 +P +AS S D V IW NT S L+H + ++ V W+ + + Sbjct: 461 SPD----GKYLASGSFDKYVHIW-------NTQSGSLVHSYQGTGGIFEVCWNARGDKVG 509 Query: 265 VSGGDNKV 272 S D V Sbjct: 510 ASASDGSV 517 Score = 51.2 bits (121), Expect = 1e-06 Identities = 71/265 (26%), Positives = 102/265 (38%), Gaps = 56/265 (21%) Query: 39 LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR-EENGTWEKSH-------EHAGHD- 89 LRGHE V+ AW +P+ ++LAS S D IW EN + GHD Sbjct: 175 LRGHESEVFICAW-NPV-SDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 232 Query: 90 ---SSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAP 146 V S+ W + G +LA GS DG + T G N A T+G + Sbjct: 233 PSNKDVTSLDW--NSDGTLLAMGSYDGFARIWTENG---------NLASTLGQH------ 275 Query: 147 AVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAW 206 G + +K NY+ S G D +W + G+ K Q+ HS DV W Sbjct: 276 ---KGPIFALKWNKKGNYV---LSAGVDKTTIIW-DAHTGEAK--QQFPFHSAPALDVDW 326 Query: 207 APSIGLPTSTIASCSQDGRVFIWT--CDDASSNTWSPKLLHKFNDVVWHVSWSITANILA 264 ++ T ASCS D + + CD K + V + W + +LA Sbjct: 327 QNNM-----TFASCSTDMCIHVCRLGCDH------PVKTFQGHTNEVNAIKWDPSGMLLA 375 Query: 265 VSGGDNKVTLWKESVDGQWVCISDV 289 D + +W D C+ D+ Sbjct: 376 SCSDDMTLKIWSMKQD---ACVHDL 397 Score = 51.2 bits (121), Expect = 1e-06 Identities = 34/105 (32%), Positives = 58/105 (55%), Gaps = 9/105 (8%) Query: 14 LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR 73 LA+ S D +V+++DV G + L H+ PV+ VA++ G LAS S+D+ V IW Sbjct: 425 LASASFDSTVRLWDVEQG--VCTHTLMKHQEPVYSVAFSPD--GKYLASGSFDKYVHIWN 480 Query: 74 EENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLL 118 ++G+ S++ G + VCW + G + +SDG++ +L Sbjct: 481 TQSGSLVHSYQGTG---GIFEVCW--NARGDKVGASASDGSVCVL 520 Score = 50.1 bits (118), Expect = 3e-06 Identities = 35/118 (29%), Positives = 57/118 (48%), Gaps = 13/118 (11%) Query: 2 IHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWA-------HP 54 ++ + D G LA+CS D ++KI+ ++ + DL+ H ++ + W+ +P Sbjct: 362 VNAIKWDPSGMLLASCSDDMTLKIWSMKQDA--CVHDLQAHSKEIYTIKWSPTGPATSNP 419 Query: 55 MYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSD 112 +LAS S+D V +W E G +H H V SV ++P G LA GS D Sbjct: 420 NSSIMLASASFDSTVRLWDVEQGVC--THTLMKHQEPVYSVAFSPD--GKYLASGSFD 473 Score = 43.9 bits (102), Expect = 2e-04 Identities = 76/302 (25%), Positives = 115/302 (38%), Gaps = 56/302 (18%) Query: 14 LATCSSDRSVKIFDVR---NGGQILIADLR------GHEGP----VWQVAWAHPMYGNIL 60 LA+ S D + +I+++ NGG + LR GH+ P V + W G +L Sbjct: 194 LASGSGDSTARIWNLNENSNGGSTQLV-LRHCIREGGHDVPSNKDVTSLDWNSD--GTLL 250 Query: 61 ASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY 120 A SYD IW E +H G + ++ W +L+ G I + Sbjct: 251 AMGSYDGFARIWTENGNLASTLGQHKG---PIFALKWNKKG-NYVLSAGVDKTTIIWDAH 306 Query: 121 TGEGQ----------WEVKKINNAHTIGCNAVSWAPAVVPGSLIDHP------SGQKPNY 164 TGE + +V NN C+ G DHP + N Sbjct: 307 TGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLG--CDHPVKTFQGHTNEVNA 364 Query: 165 IKRFASG----GC--DNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWA---PSIGLPTS 215 IK SG C D +K+W ++D + L+AHS + + W+ P+ P S Sbjct: 365 IKWDPSGMLLASCSDDMTLKIWSMKQDACVHD---LQAHSKEIYTIKWSPTGPATSNPNS 421 Query: 216 TI--ASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVT 273 +I AS S D V +W + L K + V+ V++S LA D V Sbjct: 422 SIMLASASFDSTVRLWDVEQGVCT----HTLMKHQEPVYSVAFSPDGKYLASGSFDKYVH 477 Query: 274 LW 275 +W Sbjct: 478 IW 479 >gi|19913365 transducin beta-like 1Y [Homo sapiens] Length = 522 Score = 62.8 bits (151), Expect = 4e-10 Identities = 74/308 (24%), Positives = 114/308 (37%), Gaps = 83/308 (26%) Query: 11 GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVI 70 GT LA S D +I+ NG L + L H+GP++ + W GN + S D+ I Sbjct: 247 GTLLAMGSYDGFARIW-TENGN--LASTLGQHKGPIFALKWNKK--GNYVLSAGVDKTTI 301 Query: 71 IWREENGT----------------WEKSHEHA-----------------------GHDSS 91 IW G W+ + A GH + Sbjct: 302 IWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNE 361 Query: 92 VNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNA-----VSWAP 146 VN++ W P G++LA S D + + W +K+ H + ++ + W+P Sbjct: 362 VNAIKWDPS--GMLLASCSDDMTLKI--------WSMKQDACVHDLQAHSKEIYTIKWSP 411 Query: 147 AVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAW 206 P+ PN AS D+ ++LW E Q L H + V VA+ Sbjct: 412 T--------GPATSNPNSSIMLASASFDSTVRLWDVE---QGVCTHTLMKHQEPVYSVAF 460 Query: 207 APSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDV--VWHVSWSITANILA 264 +P +AS S D V IW NT S L+H + ++ V W+ + + Sbjct: 461 SPD----GKYLASGSFDKYVHIW-------NTQSGSLVHSYQGTGGIFEVCWNARGDKVG 509 Query: 265 VSGGDNKV 272 S D V Sbjct: 510 ASASDGSV 517 Score = 51.2 bits (121), Expect = 1e-06 Identities = 71/265 (26%), Positives = 102/265 (38%), Gaps = 56/265 (21%) Query: 39 LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR-EENGTWEKSH-------EHAGHD- 89 LRGHE V+ AW +P+ ++LAS S D IW EN + GHD Sbjct: 175 LRGHESEVFICAW-NPV-SDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 232 Query: 90 ---SSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAP 146 V S+ W + G +LA GS DG + T G N A T+G + Sbjct: 233 PSNKDVTSLDW--NSDGTLLAMGSYDGFARIWTENG---------NLASTLGQH------ 275 Query: 147 AVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAW 206 G + +K NY+ S G D +W + G+ K Q+ HS DV W Sbjct: 276 ---KGPIFALKWNKKGNYV---LSAGVDKTTIIW-DAHTGEAK--QQFPFHSAPALDVDW 326 Query: 207 APSIGLPTSTIASCSQDGRVFIWT--CDDASSNTWSPKLLHKFNDVVWHVSWSITANILA 264 ++ T ASCS D + + CD K + V + W + +LA Sbjct: 327 QNNM-----TFASCSTDMCIHVCRLGCDH------PVKTFQGHTNEVNAIKWDPSGMLLA 375 Query: 265 VSGGDNKVTLWKESVDGQWVCISDV 289 D + +W D C+ D+ Sbjct: 376 SCSDDMTLKIWSMKQD---ACVHDL 397 Score = 51.2 bits (121), Expect = 1e-06 Identities = 34/105 (32%), Positives = 58/105 (55%), Gaps = 9/105 (8%) Query: 14 LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR 73 LA+ S D +V+++DV G + L H+ PV+ VA++ G LAS S+D+ V IW Sbjct: 425 LASASFDSTVRLWDVEQG--VCTHTLMKHQEPVYSVAFSPD--GKYLASGSFDKYVHIWN 480 Query: 74 EENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLL 118 ++G+ S++ G + VCW + G + +SDG++ +L Sbjct: 481 TQSGSLVHSYQGTG---GIFEVCW--NARGDKVGASASDGSVCVL 520 Score = 50.1 bits (118), Expect = 3e-06 Identities = 35/118 (29%), Positives = 57/118 (48%), Gaps = 13/118 (11%) Query: 2 IHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWA-------HP 54 ++ + D G LA+CS D ++KI+ ++ + DL+ H ++ + W+ +P Sbjct: 362 VNAIKWDPSGMLLASCSDDMTLKIWSMKQDA--CVHDLQAHSKEIYTIKWSPTGPATSNP 419 Query: 55 MYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSD 112 +LAS S+D V +W E G +H H V SV ++P G LA GS D Sbjct: 420 NSSIMLASASFDSTVRLWDVEQGVC--THTLMKHQEPVYSVAFSPD--GKYLASGSFD 473 Score = 43.9 bits (102), Expect = 2e-04 Identities = 76/302 (25%), Positives = 115/302 (38%), Gaps = 56/302 (18%) Query: 14 LATCSSDRSVKIFDVR---NGGQILIADLR------GHEGP----VWQVAWAHPMYGNIL 60 LA+ S D + +I+++ NGG + LR GH+ P V + W G +L Sbjct: 194 LASGSGDSTARIWNLNENSNGGSTQLV-LRHCIREGGHDVPSNKDVTSLDWNSD--GTLL 250 Query: 61 ASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY 120 A SYD IW E +H G + ++ W +L+ G I + Sbjct: 251 AMGSYDGFARIWTENGNLASTLGQHKG---PIFALKWNKKG-NYVLSAGVDKTTIIWDAH 306 Query: 121 TGEGQ----------WEVKKINNAHTIGCNAVSWAPAVVPGSLIDHP------SGQKPNY 164 TGE + +V NN C+ G DHP + N Sbjct: 307 TGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLG--CDHPVKTFQGHTNEVNA 364 Query: 165 IKRFASG----GC--DNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWA---PSIGLPTS 215 IK SG C D +K+W ++D + L+AHS + + W+ P+ P S Sbjct: 365 IKWDPSGMLLASCSDDMTLKIWSMKQDACVHD---LQAHSKEIYTIKWSPTGPATSNPNS 421 Query: 216 TI--ASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVT 273 +I AS S D V +W + L K + V+ V++S LA D V Sbjct: 422 SIMLASASFDSTVRLWDVEQGVCT----HTLMKHQEPVYSVAFSPDGKYLASGSFDKYVH 477 Query: 274 LW 275 +W Sbjct: 478 IW 479 >gi|15150805 transducin beta-like 1Y [Homo sapiens] Length = 522 Score = 62.8 bits (151), Expect = 4e-10 Identities = 74/308 (24%), Positives = 114/308 (37%), Gaps = 83/308 (26%) Query: 11 GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVI 70 GT LA S D +I+ NG L + L H+GP++ + W GN + S D+ I Sbjct: 247 GTLLAMGSYDGFARIW-TENGN--LASTLGQHKGPIFALKWNKK--GNYVLSAGVDKTTI 301 Query: 71 IWREENGT----------------WEKSHEHA-----------------------GHDSS 91 IW G W+ + A GH + Sbjct: 302 IWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNE 361 Query: 92 VNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNA-----VSWAP 146 VN++ W P G++LA S D + + W +K+ H + ++ + W+P Sbjct: 362 VNAIKWDPS--GMLLASCSDDMTLKI--------WSMKQDACVHDLQAHSKEIYTIKWSP 411 Query: 147 AVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAW 206 P+ PN AS D+ ++LW E Q L H + V VA+ Sbjct: 412 T--------GPATSNPNSSIMLASASFDSTVRLWDVE---QGVCTHTLMKHQEPVYSVAF 460 Query: 207 APSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDV--VWHVSWSITANILA 264 +P +AS S D V IW NT S L+H + ++ V W+ + + Sbjct: 461 SPD----GKYLASGSFDKYVHIW-------NTQSGSLVHSYQGTGGIFEVCWNARGDKVG 509 Query: 265 VSGGDNKV 272 S D V Sbjct: 510 ASASDGSV 517 Score = 51.2 bits (121), Expect = 1e-06 Identities = 71/265 (26%), Positives = 102/265 (38%), Gaps = 56/265 (21%) Query: 39 LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR-EENGTWEKSH-------EHAGHD- 89 LRGHE V+ AW +P+ ++LAS S D IW EN + GHD Sbjct: 175 LRGHESEVFICAW-NPV-SDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 232 Query: 90 ---SSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAP 146 V S+ W + G +LA GS DG + T G N A T+G + Sbjct: 233 PSNKDVTSLDW--NSDGTLLAMGSYDGFARIWTENG---------NLASTLGQH------ 275 Query: 147 AVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAW 206 G + +K NY+ S G D +W + G+ K Q+ HS DV W Sbjct: 276 ---KGPIFALKWNKKGNYV---LSAGVDKTTIIW-DAHTGEAK--QQFPFHSAPALDVDW 326 Query: 207 APSIGLPTSTIASCSQDGRVFIWT--CDDASSNTWSPKLLHKFNDVVWHVSWSITANILA 264 ++ T ASCS D + + CD K + V + W + +LA Sbjct: 327 QNNM-----TFASCSTDMCIHVCRLGCDH------PVKTFQGHTNEVNAIKWDPSGMLLA 375 Query: 265 VSGGDNKVTLWKESVDGQWVCISDV 289 D + +W D C+ D+ Sbjct: 376 SCSDDMTLKIWSMKQD---ACVHDL 397 Score = 51.2 bits (121), Expect = 1e-06 Identities = 34/105 (32%), Positives = 58/105 (55%), Gaps = 9/105 (8%) Query: 14 LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR 73 LA+ S D +V+++DV G + L H+ PV+ VA++ G LAS S+D+ V IW Sbjct: 425 LASASFDSTVRLWDVEQG--VCTHTLMKHQEPVYSVAFSPD--GKYLASGSFDKYVHIWN 480 Query: 74 EENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLL 118 ++G+ S++ G + VCW + G + +SDG++ +L Sbjct: 481 TQSGSLVHSYQGTG---GIFEVCW--NARGDKVGASASDGSVCVL 520 Score = 50.1 bits (118), Expect = 3e-06 Identities = 35/118 (29%), Positives = 57/118 (48%), Gaps = 13/118 (11%) Query: 2 IHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWA-------HP 54 ++ + D G LA+CS D ++KI+ ++ + DL+ H ++ + W+ +P Sbjct: 362 VNAIKWDPSGMLLASCSDDMTLKIWSMKQDA--CVHDLQAHSKEIYTIKWSPTGPATSNP 419 Query: 55 MYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSD 112 +LAS S+D V +W E G +H H V SV ++P G LA GS D Sbjct: 420 NSSIMLASASFDSTVRLWDVEQGVC--THTLMKHQEPVYSVAFSPD--GKYLASGSFD 473 Score = 43.9 bits (102), Expect = 2e-04 Identities = 76/302 (25%), Positives = 115/302 (38%), Gaps = 56/302 (18%) Query: 14 LATCSSDRSVKIFDVR---NGGQILIADLR------GHEGP----VWQVAWAHPMYGNIL 60 LA+ S D + +I+++ NGG + LR GH+ P V + W G +L Sbjct: 194 LASGSGDSTARIWNLNENSNGGSTQLV-LRHCIREGGHDVPSNKDVTSLDWNSD--GTLL 250 Query: 61 ASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY 120 A SYD IW E +H G + ++ W +L+ G I + Sbjct: 251 AMGSYDGFARIWTENGNLASTLGQHKG---PIFALKWNKKG-NYVLSAGVDKTTIIWDAH 306 Query: 121 TGEGQ----------WEVKKINNAHTIGCNAVSWAPAVVPGSLIDHP------SGQKPNY 164 TGE + +V NN C+ G DHP + N Sbjct: 307 TGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLG--CDHPVKTFQGHTNEVNA 364 Query: 165 IKRFASG----GC--DNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWA---PSIGLPTS 215 IK SG C D +K+W ++D + L+AHS + + W+ P+ P S Sbjct: 365 IKWDPSGMLLASCSDDMTLKIWSMKQDACVHD---LQAHSKEIYTIKWSPTGPATSNPNS 421 Query: 216 TI--ASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVT 273 +I AS S D V +W + L K + V+ V++S LA D V Sbjct: 422 SIMLASASFDSTVRLWDVEQGVCT----HTLMKHQEPVYSVAFSPDGKYLASGSFDKYVH 477 Query: 274 LW 275 +W Sbjct: 478 IW 479 >gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo sapiens] Length = 1248 Score = 60.1 bits (144), Expect = 2e-09 Identities = 47/170 (27%), Positives = 74/170 (43%), Gaps = 26/170 (15%) Query: 11 GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVI 70 G R+A+C +D+++++F G ++L +++ HE V A++ +A+CS D+KV Sbjct: 627 GQRIASCGADKTLQVFKAETGEKLL--EIKAHEDEVLCCAFSTD--DRFIATCSVDKKVK 682 Query: 71 IWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKK 130 IW G E H + H VN + + L+LA GSSD + L Q E + Sbjct: 683 IWNSMTG--ELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDL---NQKECRN 737 Query: 131 INNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLW 180 HT N ++P K AS D +KLW Sbjct: 738 TMFGHTNSVNHCRFSPD-----------------DKLLASCSADGTLKLW 770 Score = 33.1 bits (74), Expect = 0.32 Identities = 31/115 (26%), Positives = 53/115 (46%), Gaps = 19/115 (16%) Query: 166 KRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGR 225 +R AS G D ++++K E + E ++AH D V A++ IA+CS D + Sbjct: 628 QRIASCGADKTLQVFKAETGEKLLE---IKAHEDEVLCCAFSTD----DRFIATCSVDKK 680 Query: 226 VFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITAN-----ILAVSGGDNKVTLW 275 V IW N+ + +L+H +++ V+ N +LA D + LW Sbjct: 681 VKIW-------NSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLW 728 Score = 32.7 bits (73), Expect = 0.42 Identities = 46/199 (23%), Positives = 80/199 (40%), Gaps = 35/199 (17%) Query: 39 LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWA 98 +R H V+ ++ G +ASC D+ + +++ E G EK E H+ V +C A Sbjct: 611 VRPHTDAVYHACFSED--GQRIASCGADKTLQVFKAETG--EKLLEIKAHEDEV--LCCA 664 Query: 99 PHDYGLILACGSSDGAISLL-TYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHP 157 +A S D + + + TGE + + H+ N + + Sbjct: 665 FSTDDRFIATCSVDKKVKIWNSMTGE----LVHTYDEHSEQVNCCHFTNS---------- 710 Query: 158 SGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKE-EQKLEAHSDWVRDVAWAPSIGLPTST 216 ++ A+G D +KLW D KE + H++ V ++P L Sbjct: 711 -----SHHLLLATGSSDCFLKLW----DLNQKECRNTMFGHTNSVNHCRFSPDDKL---- 757 Query: 217 IASCSQDGRVFIWTCDDAS 235 +ASCS DG + +W A+ Sbjct: 758 LASCSADGTLKLWDATSAN 776 >gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo sapiens] Length = 1237 Score = 60.1 bits (144), Expect = 2e-09 Identities = 47/170 (27%), Positives = 74/170 (43%), Gaps = 26/170 (15%) Query: 11 GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVI 70 G R+A+C +D+++++F G ++L +++ HE V A++ +A+CS D+KV Sbjct: 616 GQRIASCGADKTLQVFKAETGEKLL--EIKAHEDEVLCCAFSTD--DRFIATCSVDKKVK 671 Query: 71 IWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKK 130 IW G E H + H VN + + L+LA GSSD + L Q E + Sbjct: 672 IWNSMTG--ELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDL---NQKECRN 726 Query: 131 INNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLW 180 HT N ++P K AS D +KLW Sbjct: 727 TMFGHTNSVNHCRFSPD-----------------DKLLASCSADGTLKLW 759 Score = 33.1 bits (74), Expect = 0.32 Identities = 31/115 (26%), Positives = 53/115 (46%), Gaps = 19/115 (16%) Query: 166 KRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGR 225 +R AS G D ++++K E + E ++AH D V A++ IA+CS D + Sbjct: 617 QRIASCGADKTLQVFKAETGEKLLE---IKAHEDEVLCCAFSTD----DRFIATCSVDKK 669 Query: 226 VFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITAN-----ILAVSGGDNKVTLW 275 V IW N+ + +L+H +++ V+ N +LA D + LW Sbjct: 670 VKIW-------NSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLW 717 Score = 32.7 bits (73), Expect = 0.42 Identities = 46/199 (23%), Positives = 80/199 (40%), Gaps = 35/199 (17%) Query: 39 LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWA 98 +R H V+ ++ G +ASC D+ + +++ E G EK E H+ V +C A Sbjct: 600 VRPHTDAVYHACFSED--GQRIASCGADKTLQVFKAETG--EKLLEIKAHEDEV--LCCA 653 Query: 99 PHDYGLILACGSSDGAISLL-TYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHP 157 +A S D + + + TGE + + H+ N + + Sbjct: 654 FSTDDRFIATCSVDKKVKIWNSMTGE----LVHTYDEHSEQVNCCHFTNS---------- 699 Query: 158 SGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKE-EQKLEAHSDWVRDVAWAPSIGLPTST 216 ++ A+G D +KLW D KE + H++ V ++P L Sbjct: 700 -----SHHLLLATGSSDCFLKLW----DLNQKECRNTMFGHTNSVNHCRFSPDDKL---- 746 Query: 217 IASCSQDGRVFIWTCDDAS 235 +ASCS DG + +W A+ Sbjct: 747 LASCSADGTLKLWDATSAN 765 >gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] Length = 589 Score = 59.3 bits (142), Expect = 4e-09 Identities = 60/219 (27%), Positives = 100/219 (45%), Gaps = 41/219 (18%) Query: 14 LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR 73 L +CS D S++ +D+ + ++ +GH PVW + + Y AS S+DR +W Sbjct: 357 LLSCSEDMSIRYWDLGSFTNTVL--YQGHAYPVWDLDISP--YSLYFASGSHDRTARLW- 411 Query: 74 EENGTWEKSHE---HAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKK 130 ++++++ +AGH + V+ V + P+ LA GS+D + L W ++ Sbjct: 412 ----SFDRTYPLRIYAGHLADVDCVKFHPNSN--YLATGSTDKTVRL--------WSAQQ 457 Query: 131 INNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKE 190 N+ + P + SL P+G K AS G D +KLW +KE Sbjct: 458 GNSVRLFTGHR---GPVL---SLAFSPNG------KYLASAGEDQRLKLWDLASGTLYKE 505 Query: 191 EQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIW 229 L H+D + + ++P GL IAS S D V +W Sbjct: 506 ---LRGHTDNITSLTFSPDSGL----IASASMDNSVRVW 537 Score = 52.8 bits (125), Expect = 4e-07 Identities = 60/237 (25%), Positives = 101/237 (42%), Gaps = 37/237 (15%) Query: 39 LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWA 98 LRGH GPV+ + G L SCS D + W + G++ + + GH V + + Sbjct: 338 LRGHCGPVYSTRFLADSSG--LLSCSEDMSIRYW--DLGSFTNTVLYQGHAYPVWDLDIS 393 Query: 99 PHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPS 158 P Y L A GS D L ++ + +I H + V + HP+ Sbjct: 394 P--YSLYFASGSHDRTARLWSFD---RTYPLRIYAGHLADVDCVKF-----------HPN 437 Query: 159 GQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIA 218 NY+ A+G D ++LW + Q + H V +A++P+ +A Sbjct: 438 S---NYL---ATGSTDKTVRLWSAQ---QGNSVRLFTGHRGPVLSLAFSPN----GKYLA 484 Query: 219 SCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 275 S +D R+ +W D +S T K L D + +++S + ++A + DN V +W Sbjct: 485 SAGEDQRLKLW---DLASGTLY-KELRGHTDNITSLTFSPDSGLIASASMDNSVRVW 537 >gi|19913369 transducin beta-like 3 [Homo sapiens] Length = 808 Score = 58.2 bits (139), Expect = 9e-09 Identities = 69/286 (24%), Positives = 110/286 (38%), Gaps = 48/286 (16%) Query: 11 GTRLATCSSDRSVKIFDVRNGGQIL-IADLRGHEGPVWQVAWAHPMYGNILASCSYDRKV 69 G A+C+ D+SV+I+ + GQ++ +A GH V V + + + L + S D V Sbjct: 388 GWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSR-LKESFLVTGSQDCTV 446 Query: 70 IIW-----------REENG--TWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAIS 116 +W +NG + HD +NSV AP+D +LA GS D Sbjct: 447 KLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPND--KLLATGSQDRTAK 504 Query: 117 LLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNL 176 L Q ++ + + H G V ++P + A+ D Sbjct: 505 LWALP---QCQLLGVFSGHRRGLWCVQFSP-----------------MDQVLATASADGT 544 Query: 177 IKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASS 236 IKLW ++ K E H V VA+ + + S DG V +WT Sbjct: 545 IKLWALQDFSCLK---TFEGHDASVLKVAFVSR----GTQLLSSGSDGLVKLWTI----K 593 Query: 237 NTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQ 282 N + L D VW + S + D++V LWK+ + + Sbjct: 594 NNECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILWKDVTEAE 639 Score = 43.5 bits (101), Expect = 2e-04 Identities = 48/180 (26%), Positives = 77/180 (42%), Gaps = 30/180 (16%) Query: 14 LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR 73 LAT S DR+ K++ + L+ GH +W V ++ PM +LA+ S D + +W Sbjct: 494 LATGSQDRTAKLWALPQCQ--LLGVFSGHRRGLWCVQFS-PM-DQVLATASADGTIKLWA 549 Query: 74 EENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINN 133 ++ + K+ E GHD+SV V + G L SDG + L W +K Sbjct: 550 LQDFSCLKTFE--GHDASVLKVAFVSR--GTQLLSSGSDGLVKL--------WTIKNNEC 597 Query: 134 AHTIGCNAVS-WAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQ 192 T+ + W + L DH +G D+ + LWK+ + + EEQ Sbjct: 598 VRTLDAHEDKVWG--LHCSRLDDHA-----------LTGASDSRVILWKDVTEAEQAEEQ 644 >gi|4506439 retinoblastoma binding protein 7 [Homo sapiens] Length = 425 Score = 57.8 bits (138), Expect = 1e-08 Identities = 58/239 (24%), Positives = 100/239 (41%), Gaps = 52/239 (21%) Query: 14 LATCSSDRSVKIFDVRNG---GQILIAD--LRGHEGPVWQVAWAHPMYGNILASCSYDRK 68 L + S D +V ++D+ G G+I+ A GH V VAW H ++ ++ S + D+K Sbjct: 192 LLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAW-HLLHESLFGSVADDQK 250 Query: 69 VIIWREENGTWEK-SHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWE 127 ++IW + T K SH H + VN + + P+ ILA GS+D ++L W+ Sbjct: 251 LMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYS-EFILATGSADKTVAL--------WD 301 Query: 128 VKKIN------NAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWK 181 ++ + +H V W+ P+ AS G D + +W Sbjct: 302 LRNLKLKLHTFESHKDEIFQVHWS----------------PHNETILASSGTDRRLNVWD 345 Query: 182 EEEDGQWKEEQKLE-----------AHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIW 229 + G+ + + E H+ + D +W P+ I S S+D + IW Sbjct: 346 LSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPN---EPWVICSVSEDNIMQIW 401 Score = 40.4 bits (93), Expect = 0.002 Identities = 61/288 (21%), Positives = 107/288 (37%), Gaps = 58/288 (20%) Query: 39 LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHA-----GHDSSVN 93 LRGH+ + ++W + G++L S S D V +W G E A GH + V Sbjct: 172 LRGHQKEGYGLSWNSNLSGHLL-SASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVE 230 Query: 94 SVCW-APHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGS 152 V W H+ + + D + + + + +AHT N +S+ P Sbjct: 231 DVAWHLLHE--SLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNP------ 282 Query: 153 LIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGL 212 +I A+G D + LW + + E+H D + V W+P Sbjct: 283 --------YSEFI--LATGSADKTVALW--DLRNLKLKLHTFESHKDEIFQVHWSPH--- 327 Query: 213 PTSTIASCSQDGRVFIW---------TCDDASSNTWSPKLLH-----KFNDVVWHVS--W 256 + +AS D R+ +W + +DA +H K +D W+ + W Sbjct: 328 NETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPW 387 Query: 257 SITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVSASVTEGQ 304 ++ DN + +W+ + + N + V+ S EGQ Sbjct: 388 -----VICSVSEDNIMQIWQ-------MAENIYNDEESDVTTSELEGQ 423 >gi|23199987 WD repeat domain 5B [Homo sapiens] Length = 330 Score = 55.1 bits (131), Expect = 8e-08 Identities = 71/249 (28%), Positives = 101/249 (40%), Gaps = 36/249 (14%) Query: 30 NGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHD 89 N L L GH V V ++ G LAS S DR +IIW +G +EK+ GH+ Sbjct: 28 NPNYALKCTLVGHTEAVSSVKFSPN--GEWLASSSADRLIIIWGAYDGKYEKT--LYGHN 83 Query: 90 SSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVV 149 ++ V W+ L+ A S D + L + K ++ + CN + P Sbjct: 84 LEISDVAWSSDSSRLVSA--SDDKTLKLWDVRSGKCLKTLKGHSNYVFCCN---FNP--- 135 Query: 150 PGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPS 209 P +LI SG D +K+W+ + K + L AHSD V V + S Sbjct: 136 PSNLI--------------ISGSFDETVKIWEVKTG---KCLKTLSAHSDPVSAVHFNCS 178 Query: 210 IGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGD 269 S I S S DG IW DA+S L+ N V V +S + + D Sbjct: 179 ----GSLIVSGSYDGLCRIW---DAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLD 231 Query: 270 NKVTLWKES 278 N + LW S Sbjct: 232 NTLKLWDYS 240 Score = 47.0 bits (110), Expect = 2e-05 Identities = 67/258 (25%), Positives = 110/258 (42%), Gaps = 47/258 (18%) Query: 2 IHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILA 61 I D +RL + S D+++K++DVR+G + L+GH V+ + P N++ Sbjct: 86 ISDVAWSSDSSRLVSASDDKTLKLWDVRSGK--CLKTLKGHSNYVFCCNFNPP--SNLII 141 Query: 62 SCSYDRKVIIWREENGTWEKS-HEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY 120 S S+D V IW + G K+ H+ S+V+ C G ++ GS DG + + Sbjct: 142 SGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNC-----SGSLIVSGSYDG-LCRIWD 195 Query: 121 TGEGQWEVKKINNAHTIGCNAVSWAP-------AVVPGSL----------IDHPSGQKPN 163 GQ +K + + + V ++P A + +L + +G K Sbjct: 196 AASGQC-LKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNE 254 Query: 164 YIKRFA-----------SGGCDNLIKLWKEEEDGQWKE-EQKLEAHSDWVRDVAWAPSIG 211 FA SG DNL+ +W + Q KE QKL+ H+D V A P+ Sbjct: 255 KYCIFANFSVTGGKWIVSGSEDNLVYIW----NLQTKEIVQKLQGHTDVVISAACHPTEN 310 Query: 212 LPTSTIASCSQDGRVFIW 229 L S A+ D + +W Sbjct: 311 LIAS--AALENDKTIKLW 326 >gi|14150171 THO complex 3 [Homo sapiens] Length = 351 Score = 53.9 bits (128), Expect = 2e-07 Identities = 51/204 (25%), Positives = 89/204 (43%), Gaps = 27/204 (13%) Query: 2 IHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILA 61 +H G RLA+ S D++ +F + + + RGH V Q+ W HP ++ Sbjct: 58 VHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCW-HPSNPDLFV 116 Query: 62 SCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLL--- 118 + S D+ + IW + G + ++CW+P G +A G+ D ++ + Sbjct: 117 TASGDKTIRIWDVRTTKCIATVNTKGENI---NICWSPD--GQTIAVGNKDDVVTFIDAK 171 Query: 119 TYTGEGQ----WEVKKI--NNAHTI-------GCNAVSWAPAVVPGSLID-HPSG----Q 160 T+ + + +EV +I NN + + GC + P + P I+ HPS + Sbjct: 172 THRSKAEEQFKFEVNEISWNNDNNMFFLTNGNGCINILSYPELKPVQSINAHPSNCICIK 231 Query: 161 KPNYIKRFASGGCDNLIKLWKEEE 184 K FA+G D L+ LW +E Sbjct: 232 FDPMGKYFATGSADALVSLWDVDE 255 Score = 42.4 bits (98), Expect = 5e-04 Identities = 33/109 (30%), Positives = 49/109 (44%), Gaps = 15/109 (13%) Query: 42 HEGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHD 101 H V VAW+ G LAS S+D+ ++ E K + + GH SV+ +CW P + Sbjct: 54 HSAKVHSVAWSCD--GRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWHPSN 111 Query: 102 YGLILACGSSDGAISLLTYTGEGQWEV---KKINNAHTIGCNA-VSWAP 146 L + S D I + W+V K I +T G N + W+P Sbjct: 112 PDLFVT-ASGDKTIRI--------WDVRTTKCIATVNTKGENINICWSP 151 >gi|237820620 glutamate-rich WD repeat containing 1 [Homo sapiens] Length = 446 Score = 52.8 bits (125), Expect = 4e-07 Identities = 32/115 (27%), Positives = 46/115 (40%), Gaps = 4/115 (3%) Query: 162 PNYIKRFASGGCDNLIKLWKEEEDGQWKEEQK-LEAHSDWVRDVAWAPSIGLPTSTIASC 220 P R +G C I LW + G W +Q+ H+ V D+ W+P+ + ASC Sbjct: 224 PRVTGRLLTGDCQKNIHLWTPTDGGSWHVDQRPFVGHTRSVEDLQWSPT---ENTVFASC 280 Query: 221 SQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 275 S D + IW A S + V +SWS L G D + +W Sbjct: 281 SADASIRIWDIRAAPSKACMLTTATAHDGDVNVISWSRREPFLLSGGDDGALKIW 335 Score = 42.0 bits (97), Expect = 7e-04 Identities = 42/205 (20%), Positives = 76/205 (37%), Gaps = 41/205 (20%) Query: 36 IADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWRE-ENGTWEKSHE-HAGHDSSVN 93 I GH G + + W+ + G +L + + +W + G+W GH SV Sbjct: 207 IFSFAGHMGEGFALDWSPRVTGRLLTG-DCQKNIHLWTPTDGGSWHVDQRPFVGHTRSVE 265 Query: 94 SVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINN---------AHTIGCNAVSW 144 + W+P + + +C S+D +I + W+++ + AH N +SW Sbjct: 266 DLQWSPTENTVFASC-SADASIRI--------WDIRAAPSKACMLTTATAHDGDVNVISW 316 Query: 145 APAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDV 204 S ++P + SGG D +K+W + + H V V Sbjct: 317 -------------SRREPFLL----SGGDDGALKIWDLRQFKSGSPVATFKQHVAPVTSV 359 Query: 205 AWAPSIGLPTSTIASCSQDGRVFIW 229 W P + A+ D ++ W Sbjct: 360 EWHPQ---DSGVFAASGADHQITQW 381 Score = 41.6 bits (96), Expect = 9e-04 Identities = 42/174 (24%), Positives = 70/174 (40%), Gaps = 27/174 (15%) Query: 13 RLATCSSDRSVKIFDVRNGGQILIADLR---GHEGPVWQVAWAHPMYGNILASCSYDRKV 69 RL T +++ ++ +GG + D R GH V + W+ P + ASCS D + Sbjct: 229 RLLTGDCQKNIHLWTPTDGGSWHV-DQRPFVGHTRSVEDLQWS-PTENTVFASCSADASI 286 Query: 70 IIW--REENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWE 127 IW R HD VN + W+ + L G DGA+ + W+ Sbjct: 287 RIWDIRAAPSKACMLTTATAHDGDVNVISWSRRE--PFLLSGGDDGALKI--------WD 336 Query: 128 VKKINNAHTIGCNAVSWAPAVVPGSLID-HPSGQKPNYIKRFASGGCDNLIKLW 180 +++ + G ++ V P + ++ HP FA+ G D+ I W Sbjct: 337 LRQFKS----GSPVATFKQHVAPVTSVEWHPQDSGV-----FAASGADHQITQW 381 Score = 38.1 bits (87), Expect = 0.010 Identities = 29/104 (27%), Positives = 51/104 (49%), Gaps = 9/104 (8%) Query: 12 TRLATCSSDRSVKIFDVRNGGQ--ILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKV 69 T A+CS+D S++I+D+R ++ H+G V ++W+ L S D + Sbjct: 275 TVFASCSADASIRIWDIRAAPSKACMLTTATAHDGDVNVISWSR--REPFLLSGGDDGAL 332 Query: 70 IIW---REENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGS 110 IW + ++G+ + + H + V SV W P D G+ A G+ Sbjct: 333 KIWDLRQFKSGSPVATFKQ--HVAPVTSVEWHPQDSGVFAASGA 374 >gi|223029510 echinoderm microtubule associated protein like 4 isoform b [Homo sapiens] Length = 923 Score = 52.8 bits (125), Expect = 4e-07 Identities = 56/247 (22%), Positives = 98/247 (39%), Gaps = 47/247 (19%) Query: 38 DLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR--EENGTWEKSHEHAGHDSSVNSV 95 +++GH +W +A HP + ++L +C+ DR+V +W E W + + GH Sbjct: 529 EVQGHTDELWGLA-THP-FKDLLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGH------- 579 Query: 96 CWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLID 155 C H G ++A G+ G +L E + + + HT G +S + G+ + Sbjct: 580 CADFHPSGTVVAIGTHSGRWFVL------DAETRDLVSIHTDGNEQLSVMRYSIDGTFL- 632 Query: 156 HPSGQKPNYIKRFASGGCDNLIKLWKEEEDG-QWKEEQKLEAHSDWVRDVAWAPSIGLPT 214 A G DN I L+ E+G ++ + HS ++ + W+P Sbjct: 633 -------------AVGSHDNFIYLYVVSENGRKYSRYGRCTGHSSYITHLDWSPD----N 675 Query: 215 STIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTL 274 I S S D + W + KL+ +D + W+ +L G + Sbjct: 676 KYIMSNSGDYEILYWDIPNGC------KLIRNRSDCK-DIDWTTYTCVL----GFQVFGV 724 Query: 275 WKESVDG 281 W E DG Sbjct: 725 WPEGSDG 731 >gi|19923497 echinoderm microtubule associated protein like 4 isoform a [Homo sapiens] Length = 981 Score = 52.8 bits (125), Expect = 4e-07 Identities = 56/247 (22%), Positives = 98/247 (39%), Gaps = 47/247 (19%) Query: 38 DLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR--EENGTWEKSHEHAGHDSSVNSV 95 +++GH +W +A HP + ++L +C+ DR+V +W E W + + GH Sbjct: 587 EVQGHTDELWGLA-THP-FKDLLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGH------- 637 Query: 96 CWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLID 155 C H G ++A G+ G +L E + + + HT G +S + G+ + Sbjct: 638 CADFHPSGTVVAIGTHSGRWFVL------DAETRDLVSIHTDGNEQLSVMRYSIDGTFL- 690 Query: 156 HPSGQKPNYIKRFASGGCDNLIKLWKEEEDG-QWKEEQKLEAHSDWVRDVAWAPSIGLPT 214 A G DN I L+ E+G ++ + HS ++ + W+P Sbjct: 691 -------------AVGSHDNFIYLYVVSENGRKYSRYGRCTGHSSYITHLDWSPD----N 733 Query: 215 STIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTL 274 I S S D + W + KL+ +D + W+ +L G + Sbjct: 734 KYIMSNSGDYEILYWDIPNGC------KLIRNRSDCK-DIDWTTYTCVL----GFQVFGV 782 Query: 275 WKESVDG 281 W E DG Sbjct: 783 WPEGSDG 789 >gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo sapiens] Length = 514 Score = 52.8 bits (125), Expect = 4e-07 Identities = 73/263 (27%), Positives = 102/263 (38%), Gaps = 52/263 (19%) Query: 39 LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR-EENGTWEKSH-------EHAGHD- 89 LRGHE V+ AW +P+ ++LAS S D IW EN T + G D Sbjct: 165 LRGHESEVFICAW-NPV-SDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDV 222 Query: 90 ---SSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAP 146 V S+ W + G +LA GS DG + T G N A T+G + Sbjct: 223 PSNKDVTSLDW--NSEGTLLATGSYDGFARIWTKDG---------NLASTLGQH------ 265 Query: 147 AVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAW 206 G + +K N+I S G D +W + G+ K Q+ HS DV W Sbjct: 266 ---KGPIFALKWNKKGNFI---LSAGVDKTTIIW-DAHTGEAK--QQFPFHSAPALDVDW 316 Query: 207 APSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVS 266 + +T ASCS D + I C K + V + W T N+LA Sbjct: 317 QSN-----NTFASCSTD--MCIHVCKLGQDR--PIKTFQGHTNEVNAIKWDPTGNLLASC 367 Query: 267 GGDNKVTLWKESVDGQWVCISDV 289 D + +W D C+ D+ Sbjct: 368 SDDMTLKIWSMKQDN---CVHDL 387 Score = 50.8 bits (120), Expect = 1e-06 Identities = 36/105 (34%), Positives = 56/105 (53%), Gaps = 9/105 (8%) Query: 14 LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR 73 LA+ S D +V+++DV G I I L H+ PV+ VA++ G LAS S+D+ V IW Sbjct: 415 LASASFDSTVRLWDVDRG--ICIHTLTKHQEPVYSVAFSPD--GRYLASGSFDKCVHIWN 470 Query: 74 EENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLL 118 + G S+ G + VCW + G + +SDG++ +L Sbjct: 471 TQTGALVHSYRGTG---GIFEVCW--NAAGDKVGASASDGSVCVL 510 Score = 43.9 bits (102), Expect = 2e-04 Identities = 45/178 (25%), Positives = 73/178 (41%), Gaps = 37/178 (20%) Query: 15 ATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIW-- 72 A+CS+D + + + G I +GH V + W GN+LASCS D + IW Sbjct: 323 ASCSTDMCIHVCKL--GQDRPIKTFQGHTNEVNAIKWDPT--GNLLASCSDDMTLKIWSM 378 Query: 73 REENGTWEKSHEHAGHDSSVNSVCWAPHDYG-------LILACGSSDGAISLLTYTGEGQ 125 +++N H+ H+ + ++ W+P G L+LA S D + L Sbjct: 379 KQDNCV----HDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRL-------- 426 Query: 126 WEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEE 183 W+V + HT+ P S+ P G + ASG D + +W + Sbjct: 427 WDVDRGICIHTL---TKHQEPVY---SVAFSPDG------RYLASGSFDKCVHIWNTQ 472 Score = 43.1 bits (100), Expect = 3e-04 Identities = 69/291 (23%), Positives = 113/291 (38%), Gaps = 56/291 (19%) Query: 15 ATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWRE 74 +T S + V +R GGQ D+ ++ V + W G +LA+ SYD IW + Sbjct: 202 STSGSTQLVLRHCIREGGQ----DVPSNKD-VTSLDWNSE--GTLLATGSYDGFARIWTK 254 Query: 75 ENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNA 134 + +H G + ++ W IL+ G I +TGE + + Sbjct: 255 DGNLASTLGQHKG---PIFALKWNKKG-NFILSAGVDKTTIIWDAHTGEAKQQFP----F 306 Query: 135 HTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKL 194 H+ V W Q N ++ C ++ KL GQ + + Sbjct: 307 HSAPALDVDW---------------QSNNTFASCSTDMCIHVCKL------GQDRPIKTF 345 Query: 195 EAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHV 254 + H++ V + W P+ L +ASCS D + IW+ + L N ++ + Sbjct: 346 QGHTNEVNAIKWDPTGNL----LASCSDDMTLKIWSMKQDN----CVHDLQAHNKEIYTI 397 Query: 255 SWSIT--------ANILAVSGG-DNKVTLWKESVDGQWVCISDVNKGQGSV 296 WS T AN++ S D+ V LW VD + +CI + K Q V Sbjct: 398 KWSPTGPGTNNPNANLMLASASFDSTVRLW--DVD-RGICIHTLTKHQEPV 445 >gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens] Length = 1336 Score = 52.8 bits (125), Expect = 4e-07 Identities = 52/200 (26%), Positives = 83/200 (41%), Gaps = 28/200 (14%) Query: 2 IHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILA 61 + + +++ G L T S D K+FD+RN + L RGH+ VAW HP++ + A Sbjct: 291 VMEVKLNLNGNWLLTASRDHLCKLFDIRNLKEELQV-FRGHKKEATAVAW-HPVHEGLFA 348 Query: 62 SCSYDRKVIIW----REENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISL 117 S D ++ W +E G E +HE + S+ W H G IL GS+D Sbjct: 349 SGGSDGSLLFWHVGVEKEVGGMEMAHE-----GMIWSLAW--HPLGHILCSGSNDHTSKF 401 Query: 118 LTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLID--HPSGQKPNYIKRFASGGCDN 175 T G K+ + + + ++PG D +PN + G Sbjct: 402 WTRNRPGD----KMRDRYNLN---------LLPGMSEDGVEYDDLEPNSLAVIPGMGIPE 448 Query: 176 LIKLWKEEEDGQWKEEQKLE 195 +KL E+E E ++E Sbjct: 449 QLKLAMEQEQMGKDESNEIE 468 Score = 39.7 bits (91), Expect = 0.003 Identities = 58/227 (25%), Positives = 77/227 (33%), Gaps = 65/227 (28%) Query: 2 IHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILA 61 I +A + ATCS D +V+I+D + I LRGH V V W HP G +++ Sbjct: 205 IREASFSPTDNKFATCSDDGTVRIWDFLRCHEERI--LRGHGADVKCVDW-HPTKGLVVS 261 Query: 62 SCSYDRKVI-IWREE----------------------NGTW------------------- 79 ++ I W + NG W Sbjct: 262 GSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFDIRNLK 321 Query: 80 EKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGC 139 E+ GH +V W P GL A G SDG SLL + + EV + AH Sbjct: 322 EELQVFRGHKKEATAVAWHPVHEGL-FASGGSDG--SLLFWHVGVEKEVGGMEMAH---- 374 Query: 140 NAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDG 186 + W SL HP G SG D+ K W G Sbjct: 375 EGMIW-------SLAWHPLGH------ILCSGSNDHTSKFWTRNRPG 408 Score = 34.7 bits (78), Expect = 0.11 Identities = 51/228 (22%), Positives = 85/228 (37%), Gaps = 38/228 (16%) Query: 58 NILASCSYDRKVIIWREENGTWEKSHEHA---GHDSSVNSVCWAPHDYGLILACGSSDGA 114 N A+CS D V IW + + HE GH + V V W P GL+++ GS D Sbjct: 215 NKFATCSDDGTVRIW-----DFLRCHEERILRGHGADVKCVDWHPTK-GLVVS-GSKDSQ 267 Query: 115 ISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCD 174 + W+ K + T+ + ++++ N++ + D Sbjct: 268 QPIKF------WDPKTGQSLATLHAHK---------NTVMEVKLNLNGNWL---LTASRD 309 Query: 175 NLIKLWKEEEDGQWKEE-QKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDD 233 +L KL+ + KEE Q H VAW P + AS DG + W Sbjct: 310 HLCKLF---DIRNLKEELQVFRGHKKEATAVAWHP---VHEGLFASGGSDGSLLFWHVG- 362 Query: 234 ASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDG 281 ++ H+ ++W ++W +IL D+ W + G Sbjct: 363 VEKEVGGMEMAHE--GMIWSLAWHPLGHILCSGSNDHTSKFWTRNRPG 408 >gi|89026256 PREDICTED: similar to actin related protein 2/3 complex subunit 1B [Homo sapiens] Length = 370 Score = 52.4 bits (124), Expect = 5e-07 Identities = 31/119 (26%), Positives = 53/119 (44%), Gaps = 4/119 (3%) Query: 12 TRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVII 71 T++A C ++ V I++ + +L+ H G V + WA N + +C DR + Sbjct: 19 TQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPE--SNRIVTCGTDRNAYV 76 Query: 72 WREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKK 130 W + TW+ + + + V WAP++ A GS IS+ + E W V K Sbjct: 77 WTLKGRTWKPTLVILRINRAARCVRWAPNENK--FAVGSGSRVISICYFEQENDWWVCK 133 Score = 50.1 bits (118), Expect = 3e-06 Identities = 28/106 (26%), Positives = 48/106 (45%), Gaps = 9/106 (8%) Query: 182 EEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSP 241 E+ +W + +L+ H+ V + WAP ++ I +C D ++WT TW P Sbjct: 34 EKSGAKWTKVHELKEHNGQVTGIDWAPE----SNRIVTCGTDRNAYVWT---LKGRTWKP 86 Query: 242 KL-LHKFNDVVWHVSWSITANILAVSGGDNKVTL-WKESVDGQWVC 285 L + + N V W+ N AV G +++ + E + WVC Sbjct: 87 TLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQENDWWVC 132 Score = 40.4 bits (93), Expect = 0.002 Identities = 32/131 (24%), Positives = 51/131 (38%), Gaps = 24/131 (18%) Query: 60 LASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAI--SL 117 +A C + +V I+ + W K HE H+ V + WAP + I+ CG+ A +L Sbjct: 21 IAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAP-ESNRIVTCGTDRNAYVWTL 79 Query: 118 LTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLI 177 T + + +IN A V WAP +FA G +I Sbjct: 80 KGRTWKPTLVILRINRA----ARCVRWAPNE-----------------NKFAVGSGSRVI 118 Query: 178 KLWKEEEDGQW 188 + E++ W Sbjct: 119 SICYFEQENDW 129 >gi|5031601 actin related protein 2/3 complex subunit 1B [Homo sapiens] Length = 372 Score = 52.4 bits (124), Expect = 5e-07 Identities = 31/119 (26%), Positives = 53/119 (44%), Gaps = 4/119 (3%) Query: 12 TRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVII 71 T++A C ++ V I++ + +L+ H G V + WA N + +C DR + Sbjct: 21 TQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPE--SNRIVTCGTDRNAYV 78 Query: 72 WREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKK 130 W + TW+ + + + V WAP++ A GS IS+ + E W V K Sbjct: 79 WTLKGRTWKPTLVILRINRAARCVRWAPNENK--FAVGSGSRVISICYFEQENDWWVCK 135 Score = 50.1 bits (118), Expect = 3e-06 Identities = 28/106 (26%), Positives = 48/106 (45%), Gaps = 9/106 (8%) Query: 182 EEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSP 241 E+ +W + +L+ H+ V + WAP ++ I +C D ++WT TW P Sbjct: 36 EKSGAKWTKVHELKEHNGQVTGIDWAPE----SNRIVTCGTDRNAYVWT---LKGRTWKP 88 Query: 242 KL-LHKFNDVVWHVSWSITANILAVSGGDNKVTL-WKESVDGQWVC 285 L + + N V W+ N AV G +++ + E + WVC Sbjct: 89 TLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQENDWWVC 134 Score = 40.4 bits (93), Expect = 0.002 Identities = 32/131 (24%), Positives = 51/131 (38%), Gaps = 24/131 (18%) Query: 60 LASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAI--SL 117 +A C + +V I+ + W K HE H+ V + WAP + I+ CG+ A +L Sbjct: 23 IAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAP-ESNRIVTCGTDRNAYVWTL 81 Query: 118 LTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLI 177 T + + +IN A V WAP +FA G +I Sbjct: 82 KGRTWKPTLVILRINRA----ARCVRWAPNE-----------------NKFAVGSGSRVI 120 Query: 178 KLWKEEEDGQW 188 + E++ W Sbjct: 121 SICYFEQENDW 131 >gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] Length = 526 Score = 52.0 bits (123), Expect = 7e-07 Identities = 74/265 (27%), Positives = 103/265 (38%), Gaps = 56/265 (21%) Query: 39 LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR-EENGTWEKSH-------EHAGHD- 89 LRGHE V+ AW +P+ ++LAS S D IW EN + GHD Sbjct: 177 LRGHESEVFICAW-NPV-SDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 234 Query: 90 ---SSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAP 146 V S+ W + G +LA GS DG + T G N A T+G + Sbjct: 235 PSNKDVTSLDW--NTNGTLLATGSYDGFARIWTEDG---------NLASTLGQH------ 277 Query: 147 AVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAW 206 G + +K NYI S G D +W + G+ K Q+ HS DV W Sbjct: 278 ---KGPIFALKWNRKGNYI---LSAGVDKTTIIW-DAHTGEAK--QQFPFHSAPALDVDW 328 Query: 207 APSIGLPTSTIASCSQDGRVFIWT--CDDASSNTWSPKLLHKFNDVVWHVSWSITANILA 264 + +T ASCS D + + CD K + V + W + +LA Sbjct: 329 QNN-----TTFASCSTDMCIHVCRLGCDR------PVKTFQGHTNEVNAIKWDPSGMLLA 377 Query: 265 VSGGDNKVTLWKESVDGQWVCISDV 289 D + +W Q VCI D+ Sbjct: 378 SCSDDMTLKIWSMK---QEVCIHDL 399 Score = 49.3 bits (116), Expect = 4e-06 Identities = 33/105 (31%), Positives = 56/105 (53%), Gaps = 9/105 (8%) Query: 14 LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR 73 LA+ S D +V+++D+ G + L H+ PV+ VA++ G LAS S+D+ V IW Sbjct: 427 LASASFDSTVRLWDIERG--VCTHTLTKHQEPVYSVAFSPD--GKYLASGSFDKCVHIWN 482 Query: 74 EENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLL 118 ++G S+ G + VCW + G + +SDG++ +L Sbjct: 483 TQSGNLVHSYRGTG---GIFEVCW--NARGDKVGASASDGSVCVL 522 Score = 38.9 bits (89), Expect = 0.006 Identities = 73/318 (22%), Positives = 116/318 (36%), Gaps = 88/318 (27%) Query: 14 LATCSSDRSVKIFDVR---NGGQILIADLR------GHEGP----VWQVAWAHPMYGNIL 60 LA+ S D + +I+++ NGG + LR GH+ P V + W G +L Sbjct: 196 LASGSGDSTARIWNLNENSNGGSTQLV-LRHCIREGGHDVPSNKDVTSLDWN--TNGTLL 252 Query: 61 ASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY 120 A+ SYD IW E+ +H G + ++ W IL+ G I + Sbjct: 253 ATGSYDGFARIWTEDGNLASTLGQHKG---PIFALKW-NRKGNYILSAGVDKTTIIWDAH 308 Query: 121 TGEGQ--------------WEVK-----------------------KINNAHTIGCNAVS 143 TGE + W+ K HT NA+ Sbjct: 309 TGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIK 368 Query: 144 WAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRD 203 W P+ G L+ AS D +K+W +++ + L+AH+ + Sbjct: 369 WDPS---GMLL--------------ASCSDDMTLKIWSMKQEVCIHD---LQAHNKEIYT 408 Query: 204 VAWAPSIGLPTST------IASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWS 257 + W+P+ G TS +AS S D V +W + L K + V+ V++S Sbjct: 409 IKWSPT-GPATSNPNSNIMLASASFDSTVRLWDIERGVCT----HTLTKHQEPVYSVAFS 463 Query: 258 ITANILAVSGGDNKVTLW 275 LA D V +W Sbjct: 464 PDGKYLASGSFDKCVHIW 481 >gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] Length = 526 Score = 52.0 bits (123), Expect = 7e-07 Identities = 74/265 (27%), Positives = 103/265 (38%), Gaps = 56/265 (21%) Query: 39 LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR-EENGTWEKSH-------EHAGHD- 89 LRGHE V+ AW +P+ ++LAS S D IW EN + GHD Sbjct: 177 LRGHESEVFICAW-NPV-SDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 234 Query: 90 ---SSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAP 146 V S+ W + G +LA GS DG + T G N A T+G + Sbjct: 235 PSNKDVTSLDW--NTNGTLLATGSYDGFARIWTEDG---------NLASTLGQH------ 277 Query: 147 AVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAW 206 G + +K NYI S G D +W + G+ K Q+ HS DV W Sbjct: 278 ---KGPIFALKWNRKGNYI---LSAGVDKTTIIW-DAHTGEAK--QQFPFHSAPALDVDW 328 Query: 207 APSIGLPTSTIASCSQDGRVFIWT--CDDASSNTWSPKLLHKFNDVVWHVSWSITANILA 264 + +T ASCS D + + CD K + V + W + +LA Sbjct: 329 QNN-----TTFASCSTDMCIHVCRLGCDR------PVKTFQGHTNEVNAIKWDPSGMLLA 377 Query: 265 VSGGDNKVTLWKESVDGQWVCISDV 289 D + +W Q VCI D+ Sbjct: 378 SCSDDMTLKIWSMK---QEVCIHDL 399 Score = 49.3 bits (116), Expect = 4e-06 Identities = 33/105 (31%), Positives = 56/105 (53%), Gaps = 9/105 (8%) Query: 14 LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR 73 LA+ S D +V+++D+ G + L H+ PV+ VA++ G LAS S+D+ V IW Sbjct: 427 LASASFDSTVRLWDIERG--VCTHTLTKHQEPVYSVAFSPD--GKYLASGSFDKCVHIWN 482 Query: 74 EENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLL 118 ++G S+ G + VCW + G + +SDG++ +L Sbjct: 483 TQSGNLVHSYRGTG---GIFEVCW--NARGDKVGASASDGSVCVL 522 Score = 38.9 bits (89), Expect = 0.006 Identities = 73/318 (22%), Positives = 116/318 (36%), Gaps = 88/318 (27%) Query: 14 LATCSSDRSVKIFDVR---NGGQILIADLR------GHEGP----VWQVAWAHPMYGNIL 60 LA+ S D + +I+++ NGG + LR GH+ P V + W G +L Sbjct: 196 LASGSGDSTARIWNLNENSNGGSTQLV-LRHCIREGGHDVPSNKDVTSLDWN--TNGTLL 252 Query: 61 ASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY 120 A+ SYD IW E+ +H G + ++ W IL+ G I + Sbjct: 253 ATGSYDGFARIWTEDGNLASTLGQHKG---PIFALKW-NRKGNYILSAGVDKTTIIWDAH 308 Query: 121 TGEGQ--------------WEVK-----------------------KINNAHTIGCNAVS 143 TGE + W+ K HT NA+ Sbjct: 309 TGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIK 368 Query: 144 WAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRD 203 W P+ G L+ AS D +K+W +++ + L+AH+ + Sbjct: 369 WDPS---GMLL--------------ASCSDDMTLKIWSMKQEVCIHD---LQAHNKEIYT 408 Query: 204 VAWAPSIGLPTST------IASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWS 257 + W+P+ G TS +AS S D V +W + L K + V+ V++S Sbjct: 409 IKWSPT-GPATSNPNSNIMLASASFDSTVRLWDIERGVCT----HTLTKHQEPVYSVAFS 463 Query: 258 ITANILAVSGGDNKVTLW 275 LA D V +W Sbjct: 464 PDGKYLASGSFDKCVHIW 481 >gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] Length = 577 Score = 52.0 bits (123), Expect = 7e-07 Identities = 74/265 (27%), Positives = 103/265 (38%), Gaps = 56/265 (21%) Query: 39 LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR-EENGTWEKSH-------EHAGHD- 89 LRGHE V+ AW +P+ ++LAS S D IW EN + GHD Sbjct: 228 LRGHESEVFICAW-NPV-SDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 285 Query: 90 ---SSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAP 146 V S+ W + G +LA GS DG + T G N A T+G + Sbjct: 286 PSNKDVTSLDW--NTNGTLLATGSYDGFARIWTEDG---------NLASTLGQH------ 328 Query: 147 AVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAW 206 G + +K NYI S G D +W + G+ K Q+ HS DV W Sbjct: 329 ---KGPIFALKWNRKGNYI---LSAGVDKTTIIW-DAHTGEAK--QQFPFHSAPALDVDW 379 Query: 207 APSIGLPTSTIASCSQDGRVFIWT--CDDASSNTWSPKLLHKFNDVVWHVSWSITANILA 264 + +T ASCS D + + CD K + V + W + +LA Sbjct: 380 QNN-----TTFASCSTDMCIHVCRLGCDR------PVKTFQGHTNEVNAIKWDPSGMLLA 428 Query: 265 VSGGDNKVTLWKESVDGQWVCISDV 289 D + +W Q VCI D+ Sbjct: 429 SCSDDMTLKIWSMK---QEVCIHDL 450 Score = 49.3 bits (116), Expect = 4e-06 Identities = 33/105 (31%), Positives = 56/105 (53%), Gaps = 9/105 (8%) Query: 14 LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR 73 LA+ S D +V+++D+ G + L H+ PV+ VA++ G LAS S+D+ V IW Sbjct: 478 LASASFDSTVRLWDIERG--VCTHTLTKHQEPVYSVAFSPD--GKYLASGSFDKCVHIWN 533 Query: 74 EENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLL 118 ++G S+ G + VCW + G + +SDG++ +L Sbjct: 534 TQSGNLVHSYRGTG---GIFEVCW--NARGDKVGASASDGSVCVL 573 Score = 38.9 bits (89), Expect = 0.006 Identities = 73/318 (22%), Positives = 116/318 (36%), Gaps = 88/318 (27%) Query: 14 LATCSSDRSVKIFDVR---NGGQILIADLR------GHEGP----VWQVAWAHPMYGNIL 60 LA+ S D + +I+++ NGG + LR GH+ P V + W G +L Sbjct: 247 LASGSGDSTARIWNLNENSNGGSTQLV-LRHCIREGGHDVPSNKDVTSLDWN--TNGTLL 303 Query: 61 ASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY 120 A+ SYD IW E+ +H G + ++ W IL+ G I + Sbjct: 304 ATGSYDGFARIWTEDGNLASTLGQHKG---PIFALKW-NRKGNYILSAGVDKTTIIWDAH 359 Query: 121 TGEGQ--------------WEVK-----------------------KINNAHTIGCNAVS 143 TGE + W+ K HT NA+ Sbjct: 360 TGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIK 419 Query: 144 WAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRD 203 W P+ G L+ AS D +K+W +++ + L+AH+ + Sbjct: 420 WDPS---GMLL--------------ASCSDDMTLKIWSMKQEVCIHD---LQAHNKEIYT 459 Query: 204 VAWAPSIGLPTST------IASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWS 257 + W+P+ G TS +AS S D V +W + L K + V+ V++S Sbjct: 460 IKWSPT-GPATSNPNSNIMLASASFDSTVRLWDIERGVCT----HTLTKHQEPVYSVAFS 514 Query: 258 ITANILAVSGGDNKVTLW 275 LA D V +W Sbjct: 515 PDGKYLASGSFDKCVHIW 532 >gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] Length = 577 Score = 52.0 bits (123), Expect = 7e-07 Identities = 74/265 (27%), Positives = 103/265 (38%), Gaps = 56/265 (21%) Query: 39 LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR-EENGTWEKSH-------EHAGHD- 89 LRGHE V+ AW +P+ ++LAS S D IW EN + GHD Sbjct: 228 LRGHESEVFICAW-NPV-SDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 285 Query: 90 ---SSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAP 146 V S+ W + G +LA GS DG + T G N A T+G + Sbjct: 286 PSNKDVTSLDW--NTNGTLLATGSYDGFARIWTEDG---------NLASTLGQH------ 328 Query: 147 AVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAW 206 G + +K NYI S G D +W + G+ K Q+ HS DV W Sbjct: 329 ---KGPIFALKWNRKGNYI---LSAGVDKTTIIW-DAHTGEAK--QQFPFHSAPALDVDW 379 Query: 207 APSIGLPTSTIASCSQDGRVFIWT--CDDASSNTWSPKLLHKFNDVVWHVSWSITANILA 264 + +T ASCS D + + CD K + V + W + +LA Sbjct: 380 QNN-----TTFASCSTDMCIHVCRLGCDR------PVKTFQGHTNEVNAIKWDPSGMLLA 428 Query: 265 VSGGDNKVTLWKESVDGQWVCISDV 289 D + +W Q VCI D+ Sbjct: 429 SCSDDMTLKIWSMK---QEVCIHDL 450 Score = 49.3 bits (116), Expect = 4e-06 Identities = 33/105 (31%), Positives = 56/105 (53%), Gaps = 9/105 (8%) Query: 14 LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR 73 LA+ S D +V+++D+ G + L H+ PV+ VA++ G LAS S+D+ V IW Sbjct: 478 LASASFDSTVRLWDIERG--VCTHTLTKHQEPVYSVAFSPD--GKYLASGSFDKCVHIWN 533 Query: 74 EENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLL 118 ++G S+ G + VCW + G + +SDG++ +L Sbjct: 534 TQSGNLVHSYRGTG---GIFEVCW--NARGDKVGASASDGSVCVL 573 Score = 38.9 bits (89), Expect = 0.006 Identities = 73/318 (22%), Positives = 116/318 (36%), Gaps = 88/318 (27%) Query: 14 LATCSSDRSVKIFDVR---NGGQILIADLR------GHEGP----VWQVAWAHPMYGNIL 60 LA+ S D + +I+++ NGG + LR GH+ P V + W G +L Sbjct: 247 LASGSGDSTARIWNLNENSNGGSTQLV-LRHCIREGGHDVPSNKDVTSLDWN--TNGTLL 303 Query: 61 ASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY 120 A+ SYD IW E+ +H G + ++ W IL+ G I + Sbjct: 304 ATGSYDGFARIWTEDGNLASTLGQHKG---PIFALKW-NRKGNYILSAGVDKTTIIWDAH 359 Query: 121 TGEGQ--------------WEVK-----------------------KINNAHTIGCNAVS 143 TGE + W+ K HT NA+ Sbjct: 360 TGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIK 419 Query: 144 WAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRD 203 W P+ G L+ AS D +K+W +++ + L+AH+ + Sbjct: 420 WDPS---GMLL--------------ASCSDDMTLKIWSMKQEVCIHD---LQAHNKEIYT 459 Query: 204 VAWAPSIGLPTST------IASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWS 257 + W+P+ G TS +AS S D V +W + L K + V+ V++S Sbjct: 460 IKWSPT-GPATSNPNSNIMLASASFDSTVRLWDIERGVCT----HTLTKHQEPVYSVAFS 514 Query: 258 ITANILAVSGGDNKVTLW 275 LA D V +W Sbjct: 515 PDGKYLASGSFDKCVHIW 532 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.316 0.131 0.435 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 13,785,675 Number of Sequences: 37866 Number of extensions: 643257 Number of successful extensions: 2569 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 26 Number of HSP's successfully gapped in prelim test: 186 Number of HSP's that attempted gapping in prelim test: 1813 Number of HSP's gapped (non-prelim): 625 length of query: 308 length of database: 18,247,518 effective HSP length: 102 effective length of query: 206 effective length of database: 14,385,186 effective search space: 2963348316 effective search space used: 2963348316 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.