Search of human proteins with 210032110

Search of human proteins with 210032110

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform
A [Homo sapiens]
         (300 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A...   597   e-171
gi|210032112 hydroxysteroid (17-beta) dehydrogenase 13 isoform B...   506   e-144
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]        390   e-108
gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]          232   3e-61
gi|223646115 short chain dehydrogenase/reductase family 16C, mem...   216   2e-56
gi|25282469 retinol dehydrogenase 10 [Homo sapiens]                   212   3e-55
gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo ...   177   1e-44
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s...    94   1e-19
gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]        92   6e-19
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo...    91   1e-18
gi|40254992 carbonic reductase 4 [Homo sapiens]                        82   8e-16
gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]          81   1e-15
gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]      80   2e-15
gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]       80   2e-15
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ...    80   3e-15
gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]     75   9e-14
gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo...    73   3e-13
gi|186928839 retinol dehydrogenase 12 [Homo sapiens]                   72   6e-13
gi|38424085 short-chain dehydrogenase/reductase 10 isoform b [Ho...    72   6e-13
gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Hom...    71   1e-12
gi|38348362 short-chain dehydrogenase/reductase 10 isoform e [Ho...    71   1e-12
gi|126723191 dehydrogenase/reductase (SDR family) member 4 like ...    71   1e-12
gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]         70   3e-12
gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]    69   5e-12
gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens]     67   1e-11
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ...    67   2e-11
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo...    67   2e-11
gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]    65   7e-11
gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]           65   1e-10
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa...    63   3e-10

>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
           [Homo sapiens]
          Length = 300

 Score =  597 bits (1538), Expect = e-171
 Identities = 300/300 (100%), Positives = 300/300 (100%)

Query: 1   MNIILEILLLLITIIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQ 60
           MNIILEILLLLITIIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQ
Sbjct: 1   MNIILEILLLLITIIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQ 60

Query: 61  SILVLWDINKRGVEETAAECRKLGVTAHAYVVDCSNREEIYRSLNQVKKEVGDVTIVVNN 120
           SILVLWDINKRGVEETAAECRKLGVTAHAYVVDCSNREEIYRSLNQVKKEVGDVTIVVNN
Sbjct: 61  SILVLWDINKRGVEETAAECRKLGVTAHAYVVDCSNREEIYRSLNQVKKEVGDVTIVVNN 120

Query: 121 AGTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGIP 180
           AGTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGIP
Sbjct: 121 AGTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGIP 180

Query: 181 YLIPYCSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGFTKNPSTRLWPVLETD 240
           YLIPYCSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGFTKNPSTRLWPVLETD
Sbjct: 181 YLIPYCSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGFTKNPSTRLWPVLETD 240

Query: 241 EVVRSLIDGILTNKKMIFVPSYINIFLRLQKFLPERASAILNRMQNIQFEAVVGHKIKMK 300
           EVVRSLIDGILTNKKMIFVPSYINIFLRLQKFLPERASAILNRMQNIQFEAVVGHKIKMK
Sbjct: 241 EVVRSLIDGILTNKKMIFVPSYINIFLRLQKFLPERASAILNRMQNIQFEAVVGHKIKMK 300


>gi|210032112 hydroxysteroid (17-beta) dehydrogenase 13 isoform B
           [Homo sapiens]
          Length = 264

 Score =  506 bits (1304), Expect = e-144
 Identities = 264/300 (88%), Positives = 264/300 (88%), Gaps = 36/300 (12%)

Query: 1   MNIILEILLLLITIIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQ 60
           MNIILEILLLLITIIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQ
Sbjct: 1   MNIILEILLLLITIIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQ 60

Query: 61  SILVLWDINKRGVEETAAECRKLGVTAHAYVVDCSNREEIYRSLNQVKKEVGDVTIVVNN 120
           SILVLWDINK                                    VKKEVGDVTIVVNN
Sbjct: 61  SILVLWDINK------------------------------------VKKEVGDVTIVVNN 84

Query: 121 AGTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGIP 180
           AGTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGIP
Sbjct: 85  AGTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGIP 144

Query: 181 YLIPYCSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGFTKNPSTRLWPVLETD 240
           YLIPYCSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGFTKNPSTRLWPVLETD
Sbjct: 145 YLIPYCSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGFTKNPSTRLWPVLETD 204

Query: 241 EVVRSLIDGILTNKKMIFVPSYINIFLRLQKFLPERASAILNRMQNIQFEAVVGHKIKMK 300
           EVVRSLIDGILTNKKMIFVPSYINIFLRLQKFLPERASAILNRMQNIQFEAVVGHKIKMK
Sbjct: 205 EVVRSLIDGILTNKKMIFVPSYINIFLRLQKFLPERASAILNRMQNIQFEAVVGHKIKMK 264


>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
          Length = 300

 Score =  390 bits (1001), Expect = e-108
 Identities = 190/298 (63%), Positives = 232/298 (77%)

Query: 1   MNIILEILLLLITIIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQ 60
           M  +L+ILLLL  +I   LES VK FIP+RRKSV GEIVLITGAGHGIGR T YEFAK +
Sbjct: 1   MKFLLDILLLLPLLIVCSLESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLK 60

Query: 61  SILVLWDINKRGVEETAAECRKLGVTAHAYVVDCSNREEIYRSLNQVKKEVGDVTIVVNN 120
           S LVLWDINK G+EETAA+C+ LG   H +VVDCSNRE+IY S  +VK E+GDV+I+VNN
Sbjct: 61  SKLVLWDINKHGLEETAAKCKGLGAKVHTFVVDCSNREDIYSSAKKVKAEIGDVSILVNN 120

Query: 121 AGTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGIP 180
           AG VY +DL +T+D +I KTFEVN+L HFW TKA LP+M + NHGHIVTVAS  GH  +P
Sbjct: 121 AGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVP 180

Query: 181 YLIPYCSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGFTKNPSTRLWPVLETD 240
           +L+ YCSSKFAAVGFH+ LT EL AL  TG+KT+CLCP FVNTGF KNPST L P LE +
Sbjct: 181 FLLAYCSSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNTGFIKNPSTSLGPTLEPE 240

Query: 241 EVVRSLIDGILTNKKMIFVPSYINIFLRLQKFLPERASAILNRMQNIQFEAVVGHKIK 298
           EVV  L+ GILT +KMIF+PS I     L++ LPER  A+L +  +++F+AV+G+K+K
Sbjct: 241 EVVNRLMHGILTEQKMIFIPSSIAFLTTLERILPERFLAVLKQKISVKFDAVIGYKMK 298


>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
          Length = 309

 Score =  232 bits (592), Expect = 3e-61
 Identities = 119/280 (42%), Positives = 172/280 (61%), Gaps = 4/280 (1%)

Query: 6   EILLLLITIIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQSILVL 65
           ++ + L   ++S LE+++   +P+ RK+VAGEIVLITGAG G+GR    +FA+  S+LVL
Sbjct: 10  KLFIFLGKSLFSLLEAMIFALLPKPRKNVAGEIVLITGAGSGLGRLLALQFARLGSVLVL 69

Query: 66  WDINKRGVEETAAECRKLGVT-AHAYVVDCSNREEIYRSLNQVKKEVGDVTIVVNNAGTV 124
           WDINK G EET    R+ G T  HAY  DCS +E +YR  +QVKKEVGDV+I++NNAG V
Sbjct: 70  WDINKEGNEETCKMAREAGATRVHAYTCDCSQKEGVYRVADQVKKEVGDVSILINNAGIV 129

Query: 125 YPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGIPYLIP 184
                L   DE + K+F+VN   H W  KA LP+M+  +HGH+V ++S  G  G+  L  
Sbjct: 130 TGKKFLDCPDELMEKSFDVNFKAHLWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLAD 189

Query: 185 YCSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGFTKNPST---RLWPVLETDE 241
           YC+SKFAA GF   +  E     + GIKT+ +CP F+ TG  +  +T    L P+LE   
Sbjct: 190 YCASKFAAFGFAESVFVETFVQKQKGIKTTIVCPFFIKTGMFEGCTTGCPSLLPILEPKY 249

Query: 242 VVRSLIDGILTNKKMIFVPSYINIFLRLQKFLPERASAIL 281
            V  +++ IL  K  +++P  +   + L+ FLP +   ++
Sbjct: 250 AVEKIVEAILQEKMYLYMPKLLYFMMFLKSFLPLKTGLLI 289


>gi|223646115 short chain dehydrogenase/reductase family 16C, member
           6 [Homo sapiens]
          Length = 323

 Score =  216 bits (550), Expect = 2e-56
 Identities = 120/284 (42%), Positives = 176/284 (61%), Gaps = 11/284 (3%)

Query: 1   MNIILEILLLLITIIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQ 60
           M++I +  +LL    Y +LESLV   IP+++K+VAGEIVL TGAG G+GRQ    FA+  
Sbjct: 1   MDVIADTSVLLGKFPYYFLESLVYKIIPKKKKNVAGEIVLTTGAGSGLGRQLAIYFARFG 60

Query: 61  SILVLWDINKRGVEETAAECR-KLGVTAHAYVVDCSNREEIYRSLNQVKKEVGDVTIVVN 119
           +ILVLWD+N+ G  ET    + K G     Y  DCSNR+E+YR  +QV+KE GDVTI+VN
Sbjct: 61  AILVLWDVNQEGNMETCRLAKEKGGKKVFPYTCDCSNRQEVYRVADQVRKEFGDVTILVN 120

Query: 120 NAGTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGI 179
           NA  V     L   D  + K+F VN + HFW  KA LP++++ NHGH+V ++S+ G  GI
Sbjct: 121 NADLVTGKPFLDIPDHMVEKSFLVNAITHFWTCKAFLPAVIKANHGHLVCISSIAGVVGI 180

Query: 180 P------YLIPYCS-SKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGFTKNPSTR 232
                  ++ PY S SKFAA GF   L  EL  + KT +K++ +CP F+NTG  +  +++
Sbjct: 181 NGLSDEYFVSPYYSASKFAAFGFAESLFFELTMIKKTEVKSTIVCPHFINTGMFEGCTSK 240

Query: 233 ---LWPVLETDEVVRSLIDGILTNKKMIFVPSYINIFLRLQKFL 273
              L P+LE + V + +++ IL  +  + +P +  I L L++ +
Sbjct: 241 YPFLLPILEQEYVAKKILNAILEEQVYLMIPKFAYIGLILKQII 284


>gi|25282469 retinol dehydrogenase 10 [Homo sapiens]
          Length = 341

 Score =  212 bits (540), Expect = 3e-55
 Identities = 119/313 (38%), Positives = 172/313 (54%), Gaps = 30/313 (9%)

Query: 1   MNIILEILLLLITIIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQ 60
           MNI++E  ++   ++++++ +  ++ +  + KSVAG++ LITGAG G+GR    EFA+R+
Sbjct: 1   MNIVVEFFVVTFKVLWAFVLAAARWLVRPKEKSVAGQVCLITGAGSGLGRLFALEFARRR 60

Query: 61  SILVLWDINKRGVEETAAECRKL-------------------------GVTAHAYVVDCS 95
           ++LVLWDIN +  EETA   R +                          +    Y  D  
Sbjct: 61  ALLVLWDINTQSNEETAGMVRHIYRDLEAADAAALQAGNGEEEILPHCNLQVFTYTCDVG 120

Query: 96  NREEIYRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFWITKAL 155
            RE +Y +  +V+KEVG+V+++VNNAG V    LL   DE I +T  VN   HFW TKA 
Sbjct: 121 KRENVYLTAERVRKEVGEVSVLVNNAGVVSGHHLLECPDELIERTMMVNCHAHFWTTKAF 180

Query: 156 LPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALGKTGIKTSC 215
           LP+M+E NHGHIVTVAS  G      +  YC+SKF  VGFH  L+ EL+A  K GIKT+ 
Sbjct: 181 LPTMLEINHGHIVTVASSLGLFSTAGVEDYCASKFGVVGFHESLSHELKAAEKDGIKTTL 240

Query: 216 LCPVFVNTGFTKNPSTR-----LWPVLETDEVVRSLIDGILTNKKMIFVPSYINIFLRLQ 270
           +CP  V+TG  +    R       P L+ D  V+  +  ILT++ MI  P  + I   ++
Sbjct: 241 VCPYLVDTGMFRGCRIRKEIEPFLPPLKPDYCVKQAMKAILTDQPMICTPRLMYIVTFMK 300

Query: 271 KFLPERASAILNR 283
             LP  A   + R
Sbjct: 301 SILPFEAVVCMYR 313


>gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo
           sapiens]
          Length = 302

 Score =  177 bits (449), Expect = 1e-44
 Identities = 95/275 (34%), Positives = 159/275 (57%), Gaps = 6/275 (2%)

Query: 7   ILLLLITIIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQSI-LVL 65
           +++  + +IY  +++ V   +P + + ++ E VLITG G GIGRQ   EFA+R +  +VL
Sbjct: 9   LVMFPLQMIYLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAERGARKIVL 68

Query: 66  WDINKRGVEETAAECRKLGVTAHAYVVDCSNREEIYRSLNQVKKEVGDVTIVVNNAGTVY 125
           W   ++ ++ET  E R++G   H ++ D  NREE+Y++   V+++VGD+TI+VNNA  V+
Sbjct: 69  WGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVGDITILVNNAAVVH 128

Query: 126 PADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGIPYLIPY 185
              L+ + D+ + K+  +N LG FW TKA LP M+E  +GHIV + SV     IP  I Y
Sbjct: 129 GKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDY 188

Query: 186 CSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGFTKNPSTR---LWPVLETDEV 242
           C+SK +A  F   LT  L  L   G+  + + P   +T   +    R   L+P L+ + V
Sbjct: 189 CTSKASAFAFMESLT--LGLLDCPGVSATTVLPFHTSTEMFQGMRVRFPNLFPPLKPETV 246

Query: 243 VRSLIDGILTNKKMIFVPSYINIFLRLQKFLPERA 277
            R  ++ +  N+ ++ +P  ++  + L+  LP+ A
Sbjct: 247 ARRTVEAVQLNQALLLLPWTMHALVILKSILPQAA 281


>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
           sapiens]
          Length = 339

 Score = 94.0 bits (232), Expect = 1e-19
 Identities = 64/195 (32%), Positives = 93/195 (47%), Gaps = 6/195 (3%)

Query: 38  IVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVTAHAYVV----D 93
           +V +TGA  GIG +  Y+ +K    LVL       +E     C + G      ++    D
Sbjct: 52  VVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLD 111

Query: 94  CSNREEIYRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFWITK 153
            ++      +   V +E G + I+VNN G    +  + T  +   K  E+N LG   +TK
Sbjct: 112 LTDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGTVSLTK 171

Query: 154 ALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALGKTGIKT 213
            +LP M+ER  G IVTV S+ G   +P  I YC+SK A  GF  GL +EL      GI  
Sbjct: 172 CVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATY--PGIIV 229

Query: 214 SCLCPVFVNTGFTKN 228
           S +CP  V +   +N
Sbjct: 230 SNICPGPVQSNIVEN 244


>gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]
          Length = 260

 Score = 92.0 bits (227), Expect = 6e-19
 Identities = 63/194 (32%), Positives = 91/194 (46%), Gaps = 7/194 (3%)

Query: 38  IVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGV--TAHAYVVDCS 95
           + L+TGA  GIG        ++   +V        +EE AAEC+  G   T   Y  D S
Sbjct: 13  LALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLIPYRCDLS 72

Query: 96  NREEIYRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFWITKAL 155
           N E+I    + ++ +   V I +NNAG   P  LLS         F VN+L     T+  
Sbjct: 73  NEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLALSICTREA 132

Query: 156 LPSMMERN--HGHIVTVASVCGHEGIPYLIP--YCSSKFAAVGFHRGLTSELQALGKTGI 211
             SM ERN   GHI+ + S+ GH  +P  +   Y ++K+A      GL  EL+   +T I
Sbjct: 133 YQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELRE-AQTHI 191

Query: 212 KTSCLCPVFVNTGF 225
           + +C+ P  V T F
Sbjct: 192 RATCISPGVVETQF 205


>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
           sapiens]
          Length = 325

 Score = 90.9 bits (224), Expect = 1e-18
 Identities = 64/201 (31%), Positives = 104/201 (51%), Gaps = 11/201 (5%)

Query: 38  IVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEE-----TAAECRKLGVTAHAYVV 92
           +V+ITGA  G+G++    F    + LVL   N   +EE     TA+   K+  T   Y+V
Sbjct: 54  VVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQ-THKPYLV 112

Query: 93  --DCSNREEIYRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFW 150
             D ++   I  +  ++ +  G V I+VNNAG  Y   ++ T  +   +  E N  G   
Sbjct: 113 TFDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYFGPVA 172

Query: 151 ITKALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALGKTG 210
           +TKALLPSM++R  GHIV ++S+ G   IP+   Y +SK A   F   L +E++   +  
Sbjct: 173 LTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEME---QYE 229

Query: 211 IKTSCLCPVFVNTGFTKNPST 231
           I+ + + P +++T  + N  T
Sbjct: 230 IEVTVISPGYIHTNLSVNAIT 250


>gi|40254992 carbonic reductase 4 [Homo sapiens]
          Length = 237

 Score = 81.6 bits (200), Expect = 8e-16
 Identities = 54/192 (28%), Positives = 91/192 (47%), Gaps = 6/192 (3%)

Query: 37  EIVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVTAHAYVVDCSN 96
           ++  + G   GIGR      A++   L +   N  G +  A +   LG    A+  D + 
Sbjct: 3   KVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGD---LGGDHLAFSCDVAK 59

Query: 97  REEIYRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFWITKALL 156
             ++  +  +++K +G V  +VN AG      L+ TK E++      N+LG     KA +
Sbjct: 60  EHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAM 119

Query: 157 PSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALGKTGIKTSCL 216
            +M+++  G IV V S+ G +G      Y +SK   VGF R L  E   + +  I+ + +
Sbjct: 120 RTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKE---VARKKIRVNVV 176

Query: 217 CPVFVNTGFTKN 228
            P FV+T  TK+
Sbjct: 177 APGFVHTDMTKD 188


>gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]
          Length = 311

 Score = 81.3 bits (199), Expect = 1e-15
 Identities = 55/176 (31%), Positives = 85/176 (48%), Gaps = 9/176 (5%)

Query: 33  SVAGEIVLITGAGHGIGRQTTYEFA-----KRQSILVLWDINKRGVEETAAECRKLGVTA 87
           + A   VLI+G   GIG +   + A     + Q +  + D+ K+   E AA    LG T 
Sbjct: 2   AAAPRTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAG-EALGQTL 60

Query: 88  HAYVVDCSNREEIYRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILG 147
               +D  + E + + L+ ++   G+V ++VNNAG      L       +   F+ N  G
Sbjct: 61  TVAQLDVCSDESVAQCLSCIQ---GEVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFG 117

Query: 148 HFWITKALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSEL 203
              + KA+LP M  R  GHIV ++SV G +G+ +   Y +SKFA  GF   L  +L
Sbjct: 118 AVRLVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQL 173


>gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
          Length = 292

 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 56/198 (28%), Positives = 101/198 (51%), Gaps = 12/198 (6%)

Query: 9   LLLITIIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQSILVLWDI 68
           +L + + Y Y  +  +F    R + + G+ V++TGA  GIGR+  Y  AK  + +V+   
Sbjct: 11  ILGLFMAYYYYSANEEF----RPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTAR 66

Query: 69  NKRGVEETAAECRKLGVTAHAYVV----DCSNREEIYRSLNQVKKEVGDVTIVVNNAGTV 124
           +K  +++  + C +LG  +  Y+     D +  E+    + Q  K +G + +++ N  T 
Sbjct: 67  SKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQF---VAQAGKLMGGLDMLILNHITN 123

Query: 125 YPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGIPYLIP 184
              +L       + K+ EVN L +  +T A LP M+++++G IV V+S+ G    P +  
Sbjct: 124 TSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALP-MLKQSNGSIVVVSSLAGKVAYPMVAA 182

Query: 185 YCSSKFAAVGFHRGLTSE 202
           Y +SKFA  GF   +  E
Sbjct: 183 YSASKFALDGFFSSIRKE 200


>gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
          Length = 292

 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 56/198 (28%), Positives = 101/198 (51%), Gaps = 12/198 (6%)

Query: 9   LLLITIIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQSILVLWDI 68
           +L + + Y Y  +  +F    R + + G+ V++TGA  GIGR+  Y  AK  + +V+   
Sbjct: 11  ILGLFMAYYYYSANEEF----RPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTAR 66

Query: 69  NKRGVEETAAECRKLGVTAHAYVV----DCSNREEIYRSLNQVKKEVGDVTIVVNNAGTV 124
           +K  +++  + C +LG  +  Y+     D +  E+    + Q  K +G + +++ N  T 
Sbjct: 67  SKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQF---VAQAGKLMGGLDMLILNHITN 123

Query: 125 YPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGIPYLIP 184
              +L       + K+ EVN L +  +T A LP M+++++G IV V+S+ G    P +  
Sbjct: 124 TSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALP-MLKQSNGSIVVVSSLAGKVAYPMVAA 182

Query: 185 YCSSKFAAVGFHRGLTSE 202
           Y +SKFA  GF   +  E
Sbjct: 183 YSASKFALDGFFSSIRKE 200


>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
           sapiens]
          Length = 278

 Score = 79.7 bits (195), Expect = 3e-15
 Identities = 57/219 (26%), Positives = 101/219 (46%), Gaps = 8/219 (3%)

Query: 30  RRKSVAGEIVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVTAHA 89
           RR  +A ++ L+T +  GIG       A+  + +V+    ++ V++  A  +  G++   
Sbjct: 26  RRDPLANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTG 85

Query: 90  YVVDCSNREEIYRSLNQVKKEVGDVTIVVNNAGT-VYPADLLSTKDEEITKTFEVNILGH 148
            V      E+  R +    K  G + I+V+NA    +   ++   +E   KT ++N+   
Sbjct: 86  TVCHVGKAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVKAP 145

Query: 149 FWITKALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALGK 208
             +TKA++P M +R  G +V V+S+      P   PY  SK A +G  + L  E   L  
Sbjct: 146 ALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIE---LAP 202

Query: 209 TGIKTSCLCPVFVNTGFTKNPSTRLWPVLETDEVVRSLI 247
             I+ +CL P  + T F    S  LW   E +E ++  +
Sbjct: 203 RNIRVNCLAPGLIKTSF----SRMLWMDKEKEESMKETL 237


>gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]
          Length = 245

 Score = 74.7 bits (182), Expect = 9e-14
 Identities = 45/189 (23%), Positives = 103/189 (54%), Gaps = 13/189 (6%)

Query: 36  GEIVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVTAHAYVVDCS 95
           G+++++T A  GIG+     FA+  + ++  DIN+  ++E     +  G+     V+D +
Sbjct: 6   GKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELE---KYPGIQTR--VLDVT 60

Query: 96  NREEIYRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFWITKAL 155
            +++I +  N+V++    + ++ N AG V+   +L  ++++   +  +N+   + + KA 
Sbjct: 61  KKKQIDQFANEVER----LDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRSMYLMIKAF 116

Query: 156 LPSMMERNHGHIVTVASVCGH-EGIPYLIPYCSSKFAAVGFHRGLTSELQALGKTGIKTS 214
           LP M+ +  G+I+ ++SV    +G+     Y ++K A +G  + + ++     + GI+ +
Sbjct: 117 LPKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFI---QQGIRCN 173

Query: 215 CLCPVFVNT 223
           C+CP  V+T
Sbjct: 174 CVCPGTVDT 182


>gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo
           sapiens]
          Length = 330

 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 64/223 (28%), Positives = 97/223 (43%), Gaps = 12/223 (5%)

Query: 12  ITIIYSYLESLVKFFIPQRRKSVA-----GEIVLITGAGHGIGRQTTYEFAKRQSILVLW 66
           IT+I  +   +   FIP+           G   +++GA  GIG+    E A R   ++L 
Sbjct: 38  ITVICDFYSLIRLHFIPRLGSRADLIKQYGRWAVVSGATDGIGKAYAEELASRGLNIILI 97

Query: 67  DINKRGVEETAAECRKL-GVTAHAYVVDCSNREEIYRSLNQVKKEVGDVTIVVNNAGTVY 125
             N+  ++  A +      V     V D S+  EIY  + +  K+  DV I+VNN G  Y
Sbjct: 98  SRNEEKLQVVAKDIADTYKVETDIIVADFSSGREIYLPIREALKDK-DVGILVNNVGVFY 156

Query: 126 PADLLSTK--DEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGIPYLI 183
           P     T+  ++++     VNI     +   +LP M+ER  G IVT++S    +  P L 
Sbjct: 157 PYPQYFTQLSEDKLWDIINVNIAAASLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLA 216

Query: 184 PYCSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGFT 226
            + +SK     F R L  E       GI    L P +V T  T
Sbjct: 217 AFSASKAYLDHFSRALQYE---YASKGIFVQSLIPFYVATSMT 256


>gi|186928839 retinol dehydrogenase 12 [Homo sapiens]
          Length = 316

 Score = 72.0 bits (175), Expect = 6e-13
 Identities = 73/247 (29%), Positives = 108/247 (43%), Gaps = 22/247 (8%)

Query: 1   MNIILEILLLLITIIYSYLESLVKFF---IPQRRKSVAGEIVLITGAGHGIGRQTTYEFA 57
           M + L +L    + +Y    S+ KFF   + +    + G++V+ITGA  GIG++T  E A
Sbjct: 1   MLVTLGLLTSFFSFLYMVAPSIRKFFAGGVCRTNVQLPGKVVVITGANTGIGKETARELA 60

Query: 58  KRQSILVLWDINKRGVEETAAECRKLGVTAHAYV--VDCSNREEIYRSLNQVKKEVGDVT 115
            R + + +   +    E  A+E R     +   V  +D S+ + I         E   + 
Sbjct: 61  SRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLDLSDTKSIRAFAEGFLAEEKQLH 120

Query: 116 IVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCG 175
           I++NNAG V       T D   T    VN LGHF +T  LL  +       +V V+SV  
Sbjct: 121 ILINNAG-VMMCPYSKTADGFETH-LGVNHLGHFLLTYLLLERLKVSAPARVVNVSSVAH 178

Query: 176 HEG-IPYL-----------IPYCSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNT 223
           H G IP+              YC SK A V F R L   LQ    TG+ T  + P  V +
Sbjct: 179 HIGKIPFHDLQSEKRYSRGFAYCHSKLANVLFTRELAKRLQG---TGVTTYAVHPGVVRS 235

Query: 224 GFTKNPS 230
              ++ S
Sbjct: 236 ELVRHSS 242


>gi|38424085 short-chain dehydrogenase/reductase 10 isoform b [Homo
           sapiens]
          Length = 286

 Score = 72.0 bits (175), Expect = 6e-13
 Identities = 65/259 (25%), Positives = 112/259 (43%), Gaps = 7/259 (2%)

Query: 33  SVAGEIVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVTAHAYVV 92
           S+ G  VL+TGA  G+G +  Y +A+  S LVL    +  +++    CRKLG     Y+ 
Sbjct: 26  SLQGARVLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAPKVFYIA 85

Query: 93  DCSNREEIYRSLNQ--VKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFW 150
                 E   S+ Q  + K  G   +V+N+ G   PA   +   +      +VN + +  
Sbjct: 86  ADMASPEAPESVVQFALDKLGGLDYLVLNHIGGA-PAGTRARSPQATRWLMQVNFVSYVQ 144

Query: 151 ITKALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALGKTG 210
           +T   LPS+ + + G +V V+S+ G     +  PY ++KFA  GF   L  EL       
Sbjct: 145 LTSRALPSLTD-SKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNV 203

Query: 211 IKTSCLCPV--FVNTGFTKNPSTRLWPVLETDEVVRSLIDGILTNKKMIFVPSYINIFLR 268
             T C+  +    +        TR+       +   ++I G  T    +F P    +   
Sbjct: 204 AITMCVLGLRDRASAAEAVRGVTRV-KAAPGPKAALAVIRGGATRAAGVFYPWRFRLLCL 262

Query: 269 LQKFLPERASAILNRMQNI 287
           L+++LP   +  + +  N+
Sbjct: 263 LRRWLPRPRAWFIRQELNV 281


>gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Homo
           sapiens]
          Length = 311

 Score = 71.2 bits (173), Expect = 1e-12
 Identities = 62/227 (27%), Positives = 107/227 (47%), Gaps = 13/227 (5%)

Query: 3   IILEILLLLITIIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQSI 62
           ++L +LLL I+ +    + + + +    + +V  ++V+IT A  G+G++    F    + 
Sbjct: 7   LMLPLLLLGISGLLFIYQEVSRLW---SKSAVQNKVVVITDAISGLGKECARVFHTGGAR 63

Query: 63  LVLWDINKRGVEE------TAAECRKLGVTAHAYVVDCSNREEIYRSLNQVKKEVGDVTI 116
           LVL   N   +E       + A+  K   T    ++D S+   +     +V    G V I
Sbjct: 64  LVLCGKNWERLENLYDALISVADPSKT-FTPKLVLLDLSDISCVPDVAKEVLDCYGCVDI 122

Query: 117 VVNNAGTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGH 176
           ++NNA             E   K  + N  G   +TKALLP+M+ R  G IV V ++ G 
Sbjct: 123 LINNASVKVKGPAHKISLELDKKIMDANYFGPITLTKALLPNMISRRTGQIVLVNNIQGK 182

Query: 177 EGIPYLIPYCSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNT 223
            GIP+   Y +SK AA+GF   L +E++   +  +  S + P F+ +
Sbjct: 183 FGIPFRTTYAASKHAALGFFDCLRAEVE---EYDVVISTVSPTFIRS 226


>gi|38348362 short-chain dehydrogenase/reductase 10 isoform e [Homo
           sapiens]
          Length = 315

 Score = 71.2 bits (173), Expect = 1e-12
 Identities = 54/186 (29%), Positives = 86/186 (46%), Gaps = 4/186 (2%)

Query: 33  SVAGEIVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVTAHAYVV 92
           S+ G  VL+TGA  G+G +  Y +A+  S LVL    +  +++    CRKLG     Y+ 
Sbjct: 26  SLQGARVLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAPKVFYIA 85

Query: 93  DCSNREEIYRSLNQ--VKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFW 150
                 E   S+ Q  + K  G   +V+N+ G   PA   +   +      +VN + +  
Sbjct: 86  ADMASPEAPESVVQFALDKLGGLDYLVLNHIGGA-PAGTRARSPQATRWLMQVNFVSYVQ 144

Query: 151 ITKALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALGKTG 210
           +T   LPS+ + + G +V V+S+ G     +  PY ++KFA  GF   L  EL       
Sbjct: 145 LTSRALPSLTD-SKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNV 203

Query: 211 IKTSCL 216
             T C+
Sbjct: 204 AITMCV 209


>gi|126723191 dehydrogenase/reductase (SDR family) member 4 like 2
           [Homo sapiens]
          Length = 232

 Score = 70.9 bits (172), Expect = 1e-12
 Identities = 49/188 (26%), Positives = 88/188 (46%), Gaps = 4/188 (2%)

Query: 30  RRKSVAGEIVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVTAHA 89
           RR  +  ++ L+T +  GIG       A+ ++ +V+    ++ V++  A  +  G++   
Sbjct: 26  RRDPLTNKVALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQAVATLQGEGLSVTG 85

Query: 90  YVVDCSNREEIYRSLNQVKKEVGDVTIVVNNAGT-VYPADLLSTKDEEITKTFEVNILGH 148
            V      E+  R +    K  G + I+V+NA    +   L+   +E   KT ++N+   
Sbjct: 86  TVCHVGKAEDRERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTEEVWDKTLDINVKAP 145

Query: 149 FWITKALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALGK 208
             +TKA++P M +R  G +V V+S+      P   PY  SK A +G +  L  E   L  
Sbjct: 146 ALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLNNTLAIE---LAP 202

Query: 209 TGIKTSCL 216
             I+ +CL
Sbjct: 203 RNIRVNCL 210


>gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]
          Length = 331

 Score = 69.7 bits (169), Expect = 3e-12
 Identities = 57/194 (29%), Positives = 89/194 (45%), Gaps = 17/194 (8%)

Query: 31  RKSVAGEIVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVTAH-- 88
           + ++ G+ V++TGA  GIG+QT  E A+R   ++L   +    E  A + R   +  H  
Sbjct: 33  KATIPGKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHVN 92

Query: 89  AYVVDCSNREEIYRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGH 148
           A  +D ++ + I     ++ +E   V I++NNAG +       T ++     F VN LGH
Sbjct: 93  ARHLDLASLKSIREFAAKIIEEEERVDILINNAGVMRCPHW--TTEDGFEMQFGVNHLGH 150

Query: 149 FWITKALLPSMMERNHGHIVTVAS---VCGHEGIPYL----------IPYCSSKFAAVGF 195
           F +T  LL  +       I+ ++S   V GH     L            YC SK A V F
Sbjct: 151 FLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVLF 210

Query: 196 HRGLTSELQALGKT 209
            + L+  LQ  G T
Sbjct: 211 TKELSRRLQGSGVT 224


>gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]
          Length = 312

 Score = 68.9 bits (167), Expect = 5e-12
 Identities = 59/199 (29%), Positives = 99/199 (49%), Gaps = 14/199 (7%)

Query: 36  GEIVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECR-KLGVTAHAYVVDC 94
           GE  ++TG+  GIG+    E AK    +VL   +K  +++ ++E + K  V      VD 
Sbjct: 50  GEWAVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDF 109

Query: 95  SNREEIYRSLNQVKKEVG--DVTIVVNNAGTVY--PADLLSTKDEE--ITKTFEVNILGH 148
           ++ E+IY   +++K  +   ++ I+VNN G  Y  P   L   D +  I K   +NIL  
Sbjct: 110 AS-EDIY---DKIKTGLAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSV 165

Query: 149 FWITKALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALGK 208
             +T+ +LP M+ER+ G I+ ++S  G   +P L  Y ++K     F + L  E ++   
Sbjct: 166 CKMTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRS--- 222

Query: 209 TGIKTSCLCPVFVNTGFTK 227
            G+    + P FV T   K
Sbjct: 223 KGVFVQSVLPYFVATKLAK 241


>gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens]
          Length = 736

 Score = 67.4 bits (163), Expect = 1e-11
 Identities = 58/220 (26%), Positives = 100/220 (45%), Gaps = 24/220 (10%)

Query: 36  GEIVLITGAGHGIGRQTTYEFAKRQSILVLWDINK--RGV-------EETAAECRKLGVT 86
           G +VL+TGAG G+GR     FA+R +++V+ D+    +GV       ++   E R+ G  
Sbjct: 9   GRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIRRRGGK 68

Query: 87  AHAYVVDCSNREEIYRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNIL 146
           A   V +  + EE  + +       G + +VVNNAG +         DE+      V++ 
Sbjct: 69  A---VANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIHRVHLR 125

Query: 147 GHFWITKALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQAL 206
           G F +T+A    M ++ +G I+  +S  G  G      Y ++K   +G    L  E    
Sbjct: 126 GSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAIE---- 181

Query: 207 GKTGIKTSCLCPVFVNTGFTKNPSTRLWPVLETDEVVRSL 246
              G K++  C    NT    N  +R+   +  +++V +L
Sbjct: 182 ---GRKSNIHC----NT-IAPNAGSRMTQTVMPEDLVEAL 213


>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
           [Homo sapiens]
          Length = 266

 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 53/200 (26%), Positives = 95/200 (47%), Gaps = 14/200 (7%)

Query: 34  VAGEIVLITGAGHGIGRQTTYEFAKRQSILVLWDIN-KRGVEETAAECRKLGVTAHAYV- 91
           V G++ L+TGA  GIGR        + + + L D N + GV+  AA   +       ++ 
Sbjct: 3   VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQ 62

Query: 92  VDCSNREEIYRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFWI 151
            D ++++++  +  +V    G + I+VNNAG           ++   KT ++N++     
Sbjct: 63  CDVADQQQLRDTFRKVVDHFGRLDILVNNAGV--------NNEKNWEKTLQINLVSVISG 114

Query: 152 TKALLPSMMERNHGH---IVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALGK 208
           T   L  M ++N G    I+ ++S+ G   +     YC+SK   VGF R        L  
Sbjct: 115 TYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAAN-LMN 173

Query: 209 TGIKTSCLCPVFVNTGFTKN 228
           +G++ + +CP FVNT   ++
Sbjct: 174 SGVRLNAICPGFVNTAILES 193


>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
           sapiens]
          Length = 270

 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 45/185 (24%), Positives = 88/185 (47%), Gaps = 9/185 (4%)

Query: 35  AGEIVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVTAHAYVVDC 94
           AG++V++TG G GIG      F    + +V+ D ++ G      E       A   + D 
Sbjct: 8   AGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQEL----PGAVFILCDV 63

Query: 95  SNREEIYRSLNQVKKEVGDVTIVVNNAGTVYPADL-LSTKDEEITKTFEVNILGHFWITK 153
           +  +++   +++  +  G +  VVNNAG   P      T  +   +  E+N+LG + +TK
Sbjct: 64  TQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTK 123

Query: 154 ALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALGKTGIKT 213
             LP  + ++ G+++ ++S+ G  G    +PY ++K A     + L  +       G++ 
Sbjct: 124 LALP-YLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPY---GVRV 179

Query: 214 SCLCP 218
           +C+ P
Sbjct: 180 NCISP 184


>gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]
          Length = 317

 Score = 65.1 bits (157), Expect = 7e-11
 Identities = 54/191 (28%), Positives = 87/191 (45%), Gaps = 11/191 (5%)

Query: 39  VLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVTAHAYVVDCSNRE 98
           V ITG   G G     +   R   ++   + ++G E+   +      T     +D +  E
Sbjct: 32  VFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETV---TLDVTKME 88

Query: 99  EIYRSLNQVKKEVGDVTI--VVNNAGTVYPADLLS-TKDEEITKTFEVNILGHFWITKAL 155
            I  +   VK+ VGD  +  +VNNAG + P  L      E+     +VN++G   +T ++
Sbjct: 89  SIAAATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSMNMLKVNLIGVIQVTLSM 148

Query: 156 LPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALGKTGIKTSC 215
           LP ++ R  G IV V+S+ G     ++  YC SK+    F   L  E+Q     G+K S 
Sbjct: 149 LP-LVRRARGRIVNVSSILGRVAF-FVGGYCVSKYGVEAFSDILRREIQHF---GVKISI 203

Query: 216 LCPVFVNTGFT 226
           + P +  TG T
Sbjct: 204 VEPGYFRTGMT 214


>gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]
          Length = 261

 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 59/235 (25%), Positives = 99/235 (42%), Gaps = 23/235 (9%)

Query: 29  QRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVTAH 88
           Q +  +   + L+TGAG GIGR  +   A   + +   D+++   +ET    R LG    
Sbjct: 4   QLQNRLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETV---RLLGGPGS 60

Query: 89  ----------AYVVDCSNREEIYRSLNQVKKEVG-DVTIVVNNAGTVYPADLLSTKDEEI 137
                     A+  D S        L QV+       ++VV+ AG      LL   +++ 
Sbjct: 61  KEGPPRGNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDW 120

Query: 138 TKTFEVNILGHFWITKALLPSMMERN-HGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFH 196
            K   VN+ G F +T+A   +++     G I+ ++S+ G  G      Y +SK   +G  
Sbjct: 121 DKVIAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLT 180

Query: 197 RGLTSELQALGKTGIKTSCLCPVFVNTGFTKNPSTRLWPVLETDEVVRSLIDGIL 251
           +    E   LG+ GI+ + + P     GF   P T+  P    D++   +  G L
Sbjct: 181 QTAARE---LGRHGIRCNSVLP-----GFIATPMTQKVPQKVVDKITEMIPMGHL 227


>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
           sapiens]
          Length = 332

 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 59/246 (23%), Positives = 102/246 (41%), Gaps = 10/246 (4%)

Query: 7   ILLLLITIIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQSILVLW 66
           +L     + +  L  +V   I  +  ++ G  V++TG   GIG+    E  K+ + + L 
Sbjct: 3   LLAAAFLVAFVLLLYMVSPLISPKPLALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLV 62

Query: 67  DINKRGVEETAAECRKLGVTAHAYV----VDCS-NREEIYRSLNQVKKEVGDVTIVVNNA 121
             N+  + +   E     +     V    VD S +  ++   + Q ++++G V ++VN A
Sbjct: 63  ARNEDKLLQAKKEIEMHSINDKQVVLCISVDVSQDYNQVENVIKQAQEKLGPVDMLVNCA 122

Query: 122 GTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGIPY 181
           G          +     +   +N LG  + ++A++ +M ER  G IV V+S  G  G+  
Sbjct: 123 GMAVSGKFEDLEVSTFERLMSINYLGSVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFG 182

Query: 182 LIPYCSSKFAAVGFHRGLTSELQALG---KTGIKTSCLCPVFVNTGFTKNPSTRLWPVLE 238
              Y +SKFA  G    L  E++                P F     TK   TRL  + E
Sbjct: 183 FTAYSASKFAIRGLAEALQMEVKPYNVYITVAYPPDTDTPGFAEENRTKPLETRL--ISE 240

Query: 239 TDEVVR 244
           T  V +
Sbjct: 241 TTSVCK 246


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.138    0.406 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,748,668
Number of Sequences: 37866
Number of extensions: 380689
Number of successful extensions: 1039
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 58
Number of HSP's successfully gapped in prelim test: 24
Number of HSP's that attempted gapping in prelim test: 925
Number of HSP's gapped (non-prelim): 84
length of query: 300
length of database: 18,247,518
effective HSP length: 102
effective length of query: 198
effective length of database: 14,385,186
effective search space: 2848266828
effective search space used: 2848266828
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.