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Search of human proteins with 209977097
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|209977097 tripartite motif-containing 66 [Homo sapiens]
(1216 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|209977097 tripartite motif-containing 66 [Homo sapiens] 2502 0.0
gi|47419911 transcriptional intermediary factor 1 alpha isoform ... 246 1e-64
gi|47419909 transcriptional intermediary factor 1 alpha isoform ... 246 1e-64
gi|74027251 tripartite motif-containing 33 protein isoform beta ... 244 3e-64
gi|74027249 tripartite motif-containing 33 protein isoform alpha... 234 5e-61
gi|5032179 tripartite motif-containing 28 protein [Homo sapiens] 166 1e-40
gi|91176325 bromodomain adjacent to zinc finger domain, 2A [Homo... 97 1e-19
gi|134133279 SP140 nuclear body protein-like [Homo sapiens] 90 1e-17
gi|217330601 SP140 nuclear body protein isoform 1 [Homo sapiens] 89 3e-17
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 86 3e-16
gi|190343006 SP110 nuclear body protein isoform c [Homo sapiens] 82 3e-15
gi|122939208 nuclear antigen Sp100 isoform 1 [Homo sapiens] 79 2e-14
gi|84993742 tripartite motif-containing 71 [Homo sapiens] 79 3e-14
gi|224548923 tripartite motif-containing 45 isoform 2 [Homo sapi... 78 6e-14
gi|224548921 tripartite motif-containing 45 isoform 1 [Homo sapi... 78 6e-14
gi|4557291 autoimmune regulator isoform 1 [Homo sapiens] 75 3e-13
gi|4557293 autoimmune regulator isoform 2 [Homo sapiens] 75 5e-13
gi|150170670 piccolo isoform 2 [Homo sapiens] 74 6e-13
gi|150378539 piccolo isoform 1 [Homo sapiens] 74 6e-13
gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens] 73 1e-12
gi|94681063 bromodomain adjacent to zinc finger domain, 2B [Homo... 72 2e-12
gi|51477700 mediator complex subunit 15 isoform a [Homo sapiens] 72 4e-12
gi|190343010 SP110 nuclear body protein isoform a [Homo sapiens] 71 5e-12
gi|164419758 bromodomain containing 2 [Homo sapiens] 70 9e-12
gi|4826806 bromodomain containing 2 [Homo sapiens] 70 9e-12
gi|34335264 zinc finger, MYND-type containing 8 isoform c [Homo ... 70 9e-12
gi|34335262 zinc finger, MYND-type containing 8 isoform a [Homo ... 70 9e-12
gi|34335266 zinc finger, MYND-type containing 8 isoform b [Homo ... 70 9e-12
gi|194248081 tripartite motif-containing 2 isoform 2 [Homo sapiens] 68 6e-11
gi|194248079 tripartite motif-containing 2 isoform 1 [Homo sapiens] 68 6e-11
>gi|209977097 tripartite motif-containing 66 [Homo sapiens]
Length = 1216
Score = 2502 bits (6484), Expect = 0.0
Identities = 1216/1216 (100%), Positives = 1216/1216 (100%)
Query: 1 MARNCSECKEKRAAHILCTYCNRWLCSSCTEEHRHSPVPGGPFFPRAQKGSPGVNGGPGD 60
MARNCSECKEKRAAHILCTYCNRWLCSSCTEEHRHSPVPGGPFFPRAQKGSPGVNGGPGD
Sbjct: 1 MARNCSECKEKRAAHILCTYCNRWLCSSCTEEHRHSPVPGGPFFPRAQKGSPGVNGGPGD 60
Query: 61 FTLYCPLHTQEVLKLFCETCDMLTCHSCLVVEHKEHRCRHVEEVLQNQRMLLEGVTTQVA 120
FTLYCPLHTQEVLKLFCETCDMLTCHSCLVVEHKEHRCRHVEEVLQNQRMLLEGVTTQVA
Sbjct: 61 FTLYCPLHTQEVLKLFCETCDMLTCHSCLVVEHKEHRCRHVEEVLQNQRMLLEGVTTQVA 120
Query: 121 HKKSSLQTSAKQIEDRIFEVKHQHRKVENQIKMAKMVLMNELNKQANGLIEELEGITNER 180
HKKSSLQTSAKQIEDRIFEVKHQHRKVENQIKMAKMVLMNELNKQANGLIEELEGITNER
Sbjct: 121 HKKSSLQTSAKQIEDRIFEVKHQHRKVENQIKMAKMVLMNELNKQANGLIEELEGITNER 180
Query: 181 KRKLEQQLQSIMVLNRQFEHVQNFINWAVCSKTSVPFLFSKELIVFQMQRLLETSCNTDP 240
KRKLEQQLQSIMVLNRQFEHVQNFINWAVCSKTSVPFLFSKELIVFQMQRLLETSCNTDP
Sbjct: 181 KRKLEQQLQSIMVLNRQFEHVQNFINWAVCSKTSVPFLFSKELIVFQMQRLLETSCNTDP 240
Query: 241 GSPWSIRFTWEPNFWTKQLASLGCITTEGGQMSRADAPAYGGLQGSSPFYQSHQSPVAQQ 300
GSPWSIRFTWEPNFWTKQLASLGCITTEGGQMSRADAPAYGGLQGSSPFYQSHQSPVAQQ
Sbjct: 241 GSPWSIRFTWEPNFWTKQLASLGCITTEGGQMSRADAPAYGGLQGSSPFYQSHQSPVAQQ 300
Query: 301 EALSHPSHKFQSPAVCSSSVCCSHCSPVSPSLKGQVPPPSIHPAHSFRQPPEMVPQQLGS 360
EALSHPSHKFQSPAVCSSSVCCSHCSPVSPSLKGQVPPPSIHPAHSFRQPPEMVPQQLGS
Sbjct: 301 EALSHPSHKFQSPAVCSSSVCCSHCSPVSPSLKGQVPPPSIHPAHSFRQPPEMVPQQLGS 360
Query: 361 LQCSALLPREKELACSPHPPKLLQPWLETQPPVEQESTSQRLGQQLTSQPVCIVPPQDVQ 420
LQCSALLPREKELACSPHPPKLLQPWLETQPPVEQESTSQRLGQQLTSQPVCIVPPQDVQ
Sbjct: 361 LQCSALLPREKELACSPHPPKLLQPWLETQPPVEQESTSQRLGQQLTSQPVCIVPPQDVQ 420
Query: 421 QGAHAQPTLQTPSIQVQFGHHQKLKLSHFQQQPQQQLPPPPPPLPHPPPPLPPPPQQPHP 480
QGAHAQPTLQTPSIQVQFGHHQKLKLSHFQQQPQQQLPPPPPPLPHPPPPLPPPPQQPHP
Sbjct: 421 QGAHAQPTLQTPSIQVQFGHHQKLKLSHFQQQPQQQLPPPPPPLPHPPPPLPPPPQQPHP 480
Query: 481 PLPPSQHLASSQHESPPGPACSQNMDIMHHKFELEEMQKDLELLLQAQQPSLQLSQTKSP 540
PLPPSQHLASSQHESPPGPACSQNMDIMHHKFELEEMQKDLELLLQAQQPSLQLSQTKSP
Sbjct: 481 PLPPSQHLASSQHESPPGPACSQNMDIMHHKFELEEMQKDLELLLQAQQPSLQLSQTKSP 540
Query: 541 QHLQQTIVGQINYIVRQPAPVQSQSQEETLQATDEPPASQGSKPALPLDKNTAAALPQAS 600
QHLQQTIVGQINYIVRQPAPVQSQSQEETLQATDEPPASQGSKPALPLDKNTAAALPQAS
Sbjct: 541 QHLQQTIVGQINYIVRQPAPVQSQSQEETLQATDEPPASQGSKPALPLDKNTAAALPQAS 600
Query: 601 GEETPLSVPPVDSTIQHSSPNVVRKHSTSLSIMGFSNTLEMELSSTRLERPLEPQIQSVS 660
GEETPLSVPPVDSTIQHSSPNVVRKHSTSLSIMGFSNTLEMELSSTRLERPLEPQIQSVS
Sbjct: 601 GEETPLSVPPVDSTIQHSSPNVVRKHSTSLSIMGFSNTLEMELSSTRLERPLEPQIQSVS 660
Query: 661 NLTAGAPQAVPSLLSAPPKMVSSLTSVQNQAMPSLTTSHLQTVPSLVHSTFQSMPNLISD 720
NLTAGAPQAVPSLLSAPPKMVSSLTSVQNQAMPSLTTSHLQTVPSLVHSTFQSMPNLISD
Sbjct: 661 NLTAGAPQAVPSLLSAPPKMVSSLTSVQNQAMPSLTTSHLQTVPSLVHSTFQSMPNLISD 720
Query: 721 SPQAMASLASDHPQAGPSLMSGHTQAVPSLATCPLQSIPPVSDMQPETGSSSSSGRTSGS 780
SPQAMASLASDHPQAGPSLMSGHTQAVPSLATCPLQSIPPVSDMQPETGSSSSSGRTSGS
Sbjct: 721 SPQAMASLASDHPQAGPSLMSGHTQAVPSLATCPLQSIPPVSDMQPETGSSSSSGRTSGS 780
Query: 781 LCPRDGADPSLENALCKVKLEEPINLSVKKPPLAPVVSTSTALQQYQNPKECENFEQGAL 840
LCPRDGADPSLENALCKVKLEEPINLSVKKPPLAPVVSTSTALQQYQNPKECENFEQGAL
Sbjct: 781 LCPRDGADPSLENALCKVKLEEPINLSVKKPPLAPVVSTSTALQQYQNPKECENFEQGAL 840
Query: 841 ELDAKENQSIRAFNSEHKIPYVRLERLKICAASSGEMPVFKLKPQKNDQDGSFLLIIECG 900
ELDAKENQSIRAFNSEHKIPYVRLERLKICAASSGEMPVFKLKPQKNDQDGSFLLIIECG
Sbjct: 841 ELDAKENQSIRAFNSEHKIPYVRLERLKICAASSGEMPVFKLKPQKNDQDGSFLLIIECG 900
Query: 901 TESSSMSIKVSQDRLSEATQAPGLEGRKVTVTSLAGQRPPEVEGTSPEEHRLIPRTPGAK 960
TESSSMSIKVSQDRLSEATQAPGLEGRKVTVTSLAGQRPPEVEGTSPEEHRLIPRTPGAK
Sbjct: 901 TESSSMSIKVSQDRLSEATQAPGLEGRKVTVTSLAGQRPPEVEGTSPEEHRLIPRTPGAK 960
Query: 961 KGPPAPIENEDFCAVCLNGGELLCCDRCPKVFHLSCHVPALLSFPGGEWVCTLCRSLTQP 1020
KGPPAPIENEDFCAVCLNGGELLCCDRCPKVFHLSCHVPALLSFPGGEWVCTLCRSLTQP
Sbjct: 961 KGPPAPIENEDFCAVCLNGGELLCCDRCPKVFHLSCHVPALLSFPGGEWVCTLCRSLTQP 1020
Query: 1021 EMEYDCENACYNQPGMRASPGLSMYDQKKCEKLVLSLCCNNLSLPFHEPVSPLARHYYQI 1080
EMEYDCENACYNQPGMRASPGLSMYDQKKCEKLVLSLCCNNLSLPFHEPVSPLARHYYQI
Sbjct: 1021 EMEYDCENACYNQPGMRASPGLSMYDQKKCEKLVLSLCCNNLSLPFHEPVSPLARHYYQI 1080
Query: 1081 IKRPMDLSIIRRKLQKKDPAHYTTPEEVVSDVRLMFWNCAKFNYPDSEVAEAGRCLEVFF 1140
IKRPMDLSIIRRKLQKKDPAHYTTPEEVVSDVRLMFWNCAKFNYPDSEVAEAGRCLEVFF
Sbjct: 1081 IKRPMDLSIIRRKLQKKDPAHYTTPEEVVSDVRLMFWNCAKFNYPDSEVAEAGRCLEVFF 1140
Query: 1141 EGWLKEIYPEKRFAQPRQEDSDSEEVSSESGCSTPQGFPWPPYMQEGIQPKRRRRHMENE 1200
EGWLKEIYPEKRFAQPRQEDSDSEEVSSESGCSTPQGFPWPPYMQEGIQPKRRRRHMENE
Sbjct: 1141 EGWLKEIYPEKRFAQPRQEDSDSEEVSSESGCSTPQGFPWPPYMQEGIQPKRRRRHMENE 1200
Query: 1201 RAKRMSFRLANSISQV 1216
RAKRMSFRLANSISQV
Sbjct: 1201 RAKRMSFRLANSISQV 1216
>gi|47419911 transcriptional intermediary factor 1 alpha isoform a
[Homo sapiens]
Length = 1050
Score = 246 bits (627), Expect = 1e-64
Identities = 155/415 (37%), Positives = 223/415 (53%), Gaps = 48/415 (11%)
Query: 805 NLSVKKPPLAPVVSTSTALQQYQNPKECENFEQGALELDAKENQSIRAFNSEHKIPYVRL 864
N SV P LA V+ ++ ++P +G+ +K + +S HK+P V L
Sbjct: 662 NSSVPSPGLAGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGA----DSTHKVPVVML 717
Query: 865 ERLKICAASSG-----EMPVFKLK--------PQKNDQDGSFL--LIIECGTESSSMSIK 909
E ++I +SG + PV +K PQ + S L L++ S+S
Sbjct: 718 EPIRIKQENSGPPENYDFPVVIVKQESDEESRPQNANYPRSILTSLLLNSSQSSTSEETV 777
Query: 910 VSQDRLSEATQAPGLEGRKVTVTSLAGQRPPEVEGTSPEEHRLIPRTPGAKKGPPAPIEN 969
+ D PGL S G+ E P + + K+ P N
Sbjct: 778 LRSDAPDSTGDQPGLHQDN----SSNGKS----EWLDPSQKSPLHVGETRKEDDP----N 825
Query: 970 EDFCAVCLNGGELLCCDRCPKVFHLSCHVPALLSFPGGEWVCTLCRSLTQPEMEYDCENA 1029
ED+CAVC NGGELLCC++CPKVFHLSCHVP L +FP GEW+CT CR L++PE+EYDC+
Sbjct: 826 EDWCAVCQNGGELLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDLSKPEVEYDCDAP 885
Query: 1030 CYNQPGMRAS--PGLSMYDQKKCEKLVLSLCCNNLSLPFHEPVSPLARHYYQIIKRPMDL 1087
+N + L+ D++KCE+L+L L C+ +SL F +PV YY+IIK PMDL
Sbjct: 886 SHNSEKKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQDPVPLTVPDYYKIIKNPMDL 945
Query: 1088 SIIRRKLQKKDPAHYTTPEEVVSDVRLMFWNCAKFNYPDSEVAEAGRCLEVFFEGWLKEI 1147
S I+++LQ +D + Y+ PE+ V+D RL+F NCA+FN PDSEVA AG LE +FE LK +
Sbjct: 946 STIKKRLQ-EDYSMYSKPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLENYFEELLKNL 1004
Query: 1148 YPEKRFAQPR-QEDSDSEEVSSESGCSTPQGFPWPPYMQEGIQPKRRRRHMENER 1201
YPEKRF +P + +S+ + S +S + +QP+++R ER
Sbjct: 1005 YPEKRFPKPEFRNESEDNKFSDDSD-------------DDFVQPRKKRLKSIEER 1046
Score = 213 bits (543), Expect = 7e-55
Identities = 121/389 (31%), Positives = 197/389 (50%), Gaps = 18/389 (4%)
Query: 5 CSECKEKRAAHILCTYCNRWLCSSCTEEHRHSPVPGGPFFPRAQKGSPGVNGGPGDFTLY 64
C+ C++ A+ C C WLC +C H+ + ++ SP G ++
Sbjct: 163 CTSCEDNAEANGFCVECVEWLCKTCIRAHQRVKFTKDHTVRQKEEVSPEAVGVTSQRPVF 222
Query: 65 CPLHTQEVLKLFCETCDMLTCHSCLVVEHKEHRCRHVEEVLQNQRMLLEGVTTQVAHKKS 124
CP H +E LKL+CETCD LTC C ++EHKEHR + +EE QNQ+++++ + T++ K
Sbjct: 223 CPFHKKEQLKLYCETCDKLTCRDCQLLEHKEHRYQFIEEAFQNQKVIIDTLITKLMEKTK 282
Query: 125 SLQTSAKQIEDRIFEVKHQHRKVENQIKMAKMVLMNELNKQANGLIEELEGITNERKRKL 184
++ + QI++RI EV ++VE IK+A LM E+NK+ L+ +LE + + + KL
Sbjct: 283 YIKFTGNQIQNRIIEVNQNQKQVEQDIKVAIFTLMVEINKKGKALLHQLESLAKDHRMKL 342
Query: 185 EQQLQSIMVLNRQFEHVQNFINWAVCSKTSVPFLFSKELIVFQMQRLLETSCNTDPGSPW 244
QQ Q + L++Q EHV +F WAV S +S L+SK LI ++++ LL C+ P +
Sbjct: 343 MQQQQEVAGLSKQLEHVMHFSKWAVSSGSSTALLYSKRLITYRLRHLLRARCDASPVTNN 402
Query: 245 SIRFTWEPNFWTKQLASLGCITTEG----GQMSRADAPAYGGLQGSSPFYQSHQSPVAQQ 300
+I+F +P+FW + + +LG + E QM + + Q S + S Q
Sbjct: 403 TIQFHCDPSFWAQNIINLGSLVIEDKESQPQMPKQNPVVEQNSQPPSGLSSNQLSKFPTQ 462
Query: 301 EALSH-PSHKFQSPAVCSSSVCCSHCSPV---SPSLKGQVPPPSIHPAHSFRQPPEMVPQ 356
+L+ Q + +PV +P ++G + PSI S +QPP P+
Sbjct: 463 ISLAQLRLQHMQQQVMAQRQQVQRRPAPVGLPNPRMQGPIQQPSI----SHQQPP---PR 515
Query: 357 QLGSLQCSALLPREKELACSPHPPKLLQP 385
+ S P+ PHP +L P
Sbjct: 516 LINFQNHS---PKPNGPVLPPHPQQLRYP 541
Score = 33.1 bits (74), Expect = 1.7
Identities = 23/60 (38%), Positives = 31/60 (51%), Gaps = 8/60 (13%)
Query: 443 KLKLSHFQQQ---PQQQLPPPPPPLPHPPPPLPPPPQQP---HPPLPPSQHLASSQHESP 496
+L+L H QQQ +QQ+ P P+ P P + P QQP H PP L + Q+ SP
Sbjct: 467 QLRLQHMQQQVMAQRQQVQRRPAPVGLPNPRMQGPIQQPSISHQQPPP--RLINFQNHSP 524
>gi|47419909 transcriptional intermediary factor 1 alpha isoform b
[Homo sapiens]
Length = 1016
Score = 246 bits (627), Expect = 1e-64
Identities = 155/415 (37%), Positives = 223/415 (53%), Gaps = 48/415 (11%)
Query: 805 NLSVKKPPLAPVVSTSTALQQYQNPKECENFEQGALELDAKENQSIRAFNSEHKIPYVRL 864
N SV P LA V+ ++ ++P +G+ +K + +S HK+P V L
Sbjct: 628 NSSVPSPGLAGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGA----DSTHKVPVVML 683
Query: 865 ERLKICAASSG-----EMPVFKLK--------PQKNDQDGSFL--LIIECGTESSSMSIK 909
E ++I +SG + PV +K PQ + S L L++ S+S
Sbjct: 684 EPIRIKQENSGPPENYDFPVVIVKQESDEESRPQNANYPRSILTSLLLNSSQSSTSEETV 743
Query: 910 VSQDRLSEATQAPGLEGRKVTVTSLAGQRPPEVEGTSPEEHRLIPRTPGAKKGPPAPIEN 969
+ D PGL S G+ E P + + K+ P N
Sbjct: 744 LRSDAPDSTGDQPGLHQDN----SSNGKS----EWLDPSQKSPLHVGETRKEDDP----N 791
Query: 970 EDFCAVCLNGGELLCCDRCPKVFHLSCHVPALLSFPGGEWVCTLCRSLTQPEMEYDCENA 1029
ED+CAVC NGGELLCC++CPKVFHLSCHVP L +FP GEW+CT CR L++PE+EYDC+
Sbjct: 792 EDWCAVCQNGGELLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDLSKPEVEYDCDAP 851
Query: 1030 CYNQPGMRAS--PGLSMYDQKKCEKLVLSLCCNNLSLPFHEPVSPLARHYYQIIKRPMDL 1087
+N + L+ D++KCE+L+L L C+ +SL F +PV YY+IIK PMDL
Sbjct: 852 SHNSEKKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQDPVPLTVPDYYKIIKNPMDL 911
Query: 1088 SIIRRKLQKKDPAHYTTPEEVVSDVRLMFWNCAKFNYPDSEVAEAGRCLEVFFEGWLKEI 1147
S I+++LQ +D + Y+ PE+ V+D RL+F NCA+FN PDSEVA AG LE +FE LK +
Sbjct: 912 STIKKRLQ-EDYSMYSKPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLENYFEELLKNL 970
Query: 1148 YPEKRFAQPR-QEDSDSEEVSSESGCSTPQGFPWPPYMQEGIQPKRRRRHMENER 1201
YPEKRF +P + +S+ + S +S + +QP+++R ER
Sbjct: 971 YPEKRFPKPEFRNESEDNKFSDDSD-------------DDFVQPRKKRLKSIEER 1012
Score = 211 bits (537), Expect = 3e-54
Identities = 161/619 (26%), Positives = 272/619 (43%), Gaps = 48/619 (7%)
Query: 5 CSECKEKRAAHILCTYCNRWLCSSCTEEHRHSPVPGGPFFPRAQKGSPGVNGGPGDFTLY 64
C+ C++ A+ C C WLC +C H+ + ++ SP G ++
Sbjct: 163 CTSCEDNAEANGFCVECVEWLCKTCIRAHQRVKFTKDHTVRQKEEVSPEAVGVTSQRPVF 222
Query: 65 CPLHTQEVLKLFCETCDMLTCHSCLVVEHKEHRCRHVEEVLQNQRMLLEGVTTQVAHKKS 124
CP H +E LKL+CETCD LTC C ++EHKEHR + +EE QNQ+++++ + T++ K
Sbjct: 223 CPFHKKEQLKLYCETCDKLTCRDCQLLEHKEHRYQFIEEAFQNQKVIIDTLITKLMEKTK 282
Query: 125 SLQTSAKQIEDRIFEVKHQHRKVENQIKMAKMVLMNELNKQANGLIEELEGITNERKRKL 184
++ + QI++RI EV ++VE IK+A LM E+NK+ L+ +LE + + + KL
Sbjct: 283 YIKFTGNQIQNRIIEVNQNQKQVEQDIKVAIFTLMVEINKKGKALLHQLESLAKDHRMKL 342
Query: 185 EQQLQSIMVLNRQFEHVQNFINWAVCSKTSVPFLFSKELIVFQMQRLLETSCNTDPGSPW 244
QQ Q + L++Q EHV +F WAV S +S L+SK LI ++++ LL C+ P +
Sbjct: 343 MQQQQEVAGLSKQLEHVMHFSKWAVSSGSSTALLYSKRLITYRLRHLLRARCDASPVTNN 402
Query: 245 SIRFTWEPNFWTKQLASLGCITTEG----GQMSRADAPAYGGLQGSSPFYQSHQSPVAQQ 300
+I+F +P+FW + + +LG + E QM + + Q S + S Q
Sbjct: 403 TIQFHCDPSFWAQNIINLGSLVIEDKESQPQMPKQNPVVEQNSQPPSGLSSNQLSKFPTQ 462
Query: 301 EALS-----HPSHKFQSPAVCSSSVCCSHCSPVSPSLKGQVPPPSIHPAHSFRQPPEMVP 355
+L+ H + P + + +H SP G V PP HP P + +P
Sbjct: 463 ISLAQLRLQHMQQQQPPPRLINFQ---NH----SPKPNGPVLPP--HPQQLRYPPNQNIP 513
Query: 356 QQL---GSLQCSALLP---REKELACSPHPPKLLQPWLETQPPVEQESTSQRLGQQLTSQ 409
+Q LQ + L ++ +++ P T S + G+ S
Sbjct: 514 RQAIKPNPLQMAFLAQQAIKQWQISSGQGTPSTTNSTSSTPSSPTITSAAGYDGKAFGSP 573
Query: 410 PVCIVPPQDVQQGAHAQPTLQTPS-IQVQFGHHQKLKLSHFQQQPQQQLPPPPPPLPHPP 468
+ + P + P + S I + + + H Q +P P P
Sbjct: 574 MIDLSSPVGGSYNLPSLPDIDCSSTIMLDNIVRKDTNIDHGQPRPPSNRTVQSPNSSVPS 633
Query: 469 PPLPPPPQQP--HPPL-PPSQHLASSQHES-----PPGPACSQNMD-IMHHKFELEEMQK 519
P L P HPP+ PS S+ S P G + + +M +++
Sbjct: 634 PGLAGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPIRIKQENS 693
Query: 520 ------DLELLLQAQQPSLQLSQTKSPQHLQQTIVGQINYIVRQPAPVQSQSQEETLQAT 573
D +++ Q+ + PQ+ + ++ QS + EET+ +
Sbjct: 694 GPPENYDFPVVIVKQES----DEESRPQNANYPRSILTSLLLNSS---QSSTSEETVLRS 746
Query: 574 DEPPASQGSKPALPLDKNT 592
D P S G +P L D ++
Sbjct: 747 DAPD-STGDQPGLHQDNSS 764
>gi|74027251 tripartite motif-containing 33 protein isoform beta [Homo
sapiens]
Length = 1110
Score = 244 bits (624), Expect = 3e-64
Identities = 115/228 (50%), Positives = 161/228 (70%), Gaps = 16/228 (7%)
Query: 969 NEDFCAVCLNGGELLCCDRCPKVFHLSCHVPALLSFPGGEWVCTLCRSLTQPEMEYDCEN 1028
NED+CAVC NGG+LLCC++CPKVFHL+CHVP LLSFP G+W+CT CR + +PE+EYDC+N
Sbjct: 886 NEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDN 945
Query: 1029 ACYNQPGMRASPGLSMYDQKKCEKLVLSLCCNNLSLPFHEPVSPLARHYYQIIKRPMDLS 1088
+++ G A GLS DQ+KCE+L+L L C+ LS+ F EPV +YY+IIK+PMDLS
Sbjct: 946 LQHSKKGKTAQ-GLSPVDQRKCERLLLYLYCHELSIEFQEPVPASIPNYYKIIKKPMDLS 1004
Query: 1089 IIRRKLQKKDPAHYTTPEEVVSDVRLMFWNCAKFNYPDSEVAEAGRCLEVFFEGWLKEIY 1148
+++KLQKK HY P++ V+DVRL+F NC +FN DSEVA+AG+ + ++FE L EIY
Sbjct: 1005 TVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNEADSEVAQAGKAVALYFEDKLTEIY 1064
Query: 1149 PEKRFA--QPRQEDSDSEEVSSESGCSTPQGFPWPPYMQEGIQPKRRR 1194
++ FA +++ D EV+ +S ++ IQP+R+R
Sbjct: 1065 SDRTFAPLPEFEQEEDDGEVTEDSD-------------EDFIQPRRKR 1099
Score = 228 bits (582), Expect = 2e-59
Identities = 129/393 (32%), Positives = 199/393 (50%), Gaps = 39/393 (9%)
Query: 5 CSECKEKRAAHILCTYCNRWLCSSCTEEHRHSPVPGGPFFPRAQKGSPGVNGGPGDFTLY 64
C+ C++ +A C C WLC +C E H+ + + S V G G ++
Sbjct: 217 CTSCEDNASAVGFCVECGEWLCKTCIEAHQRVKFTKDHLIRKKEDVSESV-GASGQRPVF 275
Query: 65 CPLHTQEVLKLFCETCDMLTCHSCLVVEHKEHRCRHVEEVLQNQRMLLEGVTTQVAHKKS 124
CP+H QE LKLFCETCD LTC C ++EHKEHR + +EE QNQ+ +E + ++ KK+
Sbjct: 276 CPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKN 335
Query: 125 SLQTSAKQIEDRIFEVKHQHRKVENQIKMAKMVLMNELNKQANGLIEELEGITNERKRKL 184
+ +A Q+++RI EV +++VE +IK+A L+NE+NK+ L+++LE +T ER+ KL
Sbjct: 336 YVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKL 395
Query: 185 EQQLQSIMVLNRQFEHVQNFINWAVCSKTSVPFLFSKELIVFQMQRLLETSCNTDPGSPW 244
QQ I L+RQ +HV NF NWA+ S +S L+SK LI FQ++ +L+ C+ P +
Sbjct: 396 LQQQNDITGLSRQVKHVMNFTNWAIASGSSTALLYSKRLITFQLRHILKARCDPVPAANG 455
Query: 245 SIRFTWEPNFWTKQLASLGCITTEGGQMSRADAPAY--GGLQGSSPFYQSHQSPV----- 297
+IRF +P FW K + +LG + E AP Y + G P +H S
Sbjct: 456 AIRFHCDPTFWAKNVVNLGNLVIES-----KPAPGYTPNVVVGQVPPGTNHISKTPGQIN 510
Query: 298 --------AQQEALSHPSHKFQ--------SPAVCSSSVCCSHCSPVSPSLKGQVPPPSI 341
QQ+ + + Q +P +++ H +P + Q PP I
Sbjct: 511 LAQLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLI 570
Query: 342 HPAHSFRQPPEMVPQQLGSLQCSALLPREKELA 374
+ Q G++ C A + LA
Sbjct: 571 ----------SVQTMQRGNMNCGAFQAHQMRLA 593
Score = 40.8 bits (94), Expect = 0.008
Identities = 75/340 (22%), Positives = 131/340 (38%), Gaps = 53/340 (15%)
Query: 511 KFELEEMQKDLELLLQAQQPSLQLSQTKSPQHLQQTIVGQINYIVRQPAPVQSQSQEETL 570
+ L+ MQ+ + Q +++ Q +P T Q RQ AP Q Q L
Sbjct: 513 QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHP---RQAAPQMLQQQPPRL 569
Query: 571 QATDEPP-------ASQGSKPALPLDKNTAAALPQASGEETPLSVPPVDSTIQHSSPNVV 623
+ A Q + L + +P+ SG + + P + QHS+P
Sbjct: 570 ISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGIPRHSGPQYSMMQPHLQR--QHSNPG-- 625
Query: 624 RKHSTSLSIMGFSNTLEMELSSTRLERPLEPQIQSVSNLTAGAPQAVPSLLSAPPKMVSS 683
H+ ++ NT P P +++N G PS+ + +++ S
Sbjct: 626 --HAGPFPVVSVHNTTI---------NPTSPTTATMANANRGPTS--PSVTAI--ELIPS 670
Query: 684 LTSVQN-QAMPSLTTSHLQTVPSLVHSTFQSMPNLISDSPQAMASLASDHPQAGPSLMSG 742
+T+ +N ++P + L+ S S + IS S ++ +P GPS +S
Sbjct: 671 VTNPENLPSLPDIPPIQLEDAGS--SSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALSP 728
Query: 743 HTQAVPSLATCPLQSIPPVSDMQPETGSSSSSGRTSGSLCPRDGAD-------PSLENAL 795
+ + + T P++ PP + GS SSGRT+ +D P E+ +
Sbjct: 729 GSSGLSNSHT-PVR--PPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTEDEI 785
Query: 796 CK----VKLEEPIN-------LSVKKPPLAPVVSTSTALQ 824
C VK E+ + LS + L P +ST+ L+
Sbjct: 786 CSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLE 825
>gi|74027249 tripartite motif-containing 33 protein isoform alpha
[Homo sapiens]
Length = 1127
Score = 234 bits (596), Expect = 5e-61
Identities = 114/245 (46%), Positives = 162/245 (66%), Gaps = 33/245 (13%)
Query: 969 NEDFCAVCLNGGELLCCDRCPKVFHLSCHVPALLSFPGGEWVCTLCRSLTQPEMEYDCEN 1028
NED+CAVC NGG+LLCC++CPKVFHL+CHVP LLSFP G+W+CT CR + +PE+EYDC+N
Sbjct: 886 NEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDN 945
Query: 1029 ACYNQPGMRASPGLSMYDQKKCEKLVLSLCCNNLSLPFHEPVSPLARHYYQIIKRPMDLS 1088
+++ G + + GLS DQ+KCE+L+L L C+ LS+ F EPV +YY+IIK+PMDLS
Sbjct: 946 LQHSKKG-KTAQGLSPVDQRKCERLLLYLYCHELSIEFQEPVPASIPNYYKIIKKPMDLS 1004
Query: 1089 IIRRKLQKKDPAHYTTPEEVVSDVRLMFWNCAKFN-----------------YPDSEVAE 1131
+++KLQKK HY P++ V+DVRL+F NC +FN DSEVA+
Sbjct: 1005 TVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINLKADSEVAQ 1064
Query: 1132 AGRCLEVFFEGWLKEIYPEKRFA--QPRQEDSDSEEVSSESGCSTPQGFPWPPYMQEGIQ 1189
AG+ + ++FE L EIY ++ FA +++ D EV+ +S ++ IQ
Sbjct: 1065 AGKAVALYFEDKLTEIYSDRTFAPLPEFEQEEDDGEVTEDSD-------------EDFIQ 1111
Query: 1190 PKRRR 1194
P+R+R
Sbjct: 1112 PRRKR 1116
Score = 228 bits (582), Expect = 2e-59
Identities = 129/393 (32%), Positives = 199/393 (50%), Gaps = 39/393 (9%)
Query: 5 CSECKEKRAAHILCTYCNRWLCSSCTEEHRHSPVPGGPFFPRAQKGSPGVNGGPGDFTLY 64
C+ C++ +A C C WLC +C E H+ + + S V G G ++
Sbjct: 217 CTSCEDNASAVGFCVECGEWLCKTCIEAHQRVKFTKDHLIRKKEDVSESV-GASGQRPVF 275
Query: 65 CPLHTQEVLKLFCETCDMLTCHSCLVVEHKEHRCRHVEEVLQNQRMLLEGVTTQVAHKKS 124
CP+H QE LKLFCETCD LTC C ++EHKEHR + +EE QNQ+ +E + ++ KK+
Sbjct: 276 CPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKN 335
Query: 125 SLQTSAKQIEDRIFEVKHQHRKVENQIKMAKMVLMNELNKQANGLIEELEGITNERKRKL 184
+ +A Q+++RI EV +++VE +IK+A L+NE+NK+ L+++LE +T ER+ KL
Sbjct: 336 YVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKL 395
Query: 185 EQQLQSIMVLNRQFEHVQNFINWAVCSKTSVPFLFSKELIVFQMQRLLETSCNTDPGSPW 244
QQ I L+RQ +HV NF NWA+ S +S L+SK LI FQ++ +L+ C+ P +
Sbjct: 396 LQQQNDITGLSRQVKHVMNFTNWAIASGSSTALLYSKRLITFQLRHILKARCDPVPAANG 455
Query: 245 SIRFTWEPNFWTKQLASLGCITTEGGQMSRADAPAY--GGLQGSSPFYQSHQSPV----- 297
+IRF +P FW K + +LG + E AP Y + G P +H S
Sbjct: 456 AIRFHCDPTFWAKNVVNLGNLVIES-----KPAPGYTPNVVVGQVPPGTNHISKTPGQIN 510
Query: 298 --------AQQEALSHPSHKFQ--------SPAVCSSSVCCSHCSPVSPSLKGQVPPPSI 341
QQ+ + + Q +P +++ H +P + Q PP I
Sbjct: 511 LAQLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLI 570
Query: 342 HPAHSFRQPPEMVPQQLGSLQCSALLPREKELA 374
+ Q G++ C A + LA
Sbjct: 571 ----------SVQTMQRGNMNCGAFQAHQMRLA 593
Score = 40.8 bits (94), Expect = 0.008
Identities = 75/340 (22%), Positives = 131/340 (38%), Gaps = 53/340 (15%)
Query: 511 KFELEEMQKDLELLLQAQQPSLQLSQTKSPQHLQQTIVGQINYIVRQPAPVQSQSQEETL 570
+ L+ MQ+ + Q +++ Q +P T Q RQ AP Q Q L
Sbjct: 513 QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHP---RQAAPQMLQQQPPRL 569
Query: 571 QATDEPP-------ASQGSKPALPLDKNTAAALPQASGEETPLSVPPVDSTIQHSSPNVV 623
+ A Q + L + +P+ SG + + P + QHS+P
Sbjct: 570 ISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGIPRHSGPQYSMMQPHLQR--QHSNPG-- 625
Query: 624 RKHSTSLSIMGFSNTLEMELSSTRLERPLEPQIQSVSNLTAGAPQAVPSLLSAPPKMVSS 683
H+ ++ NT P P +++N G PS+ + +++ S
Sbjct: 626 --HAGPFPVVSVHNTTI---------NPTSPTTATMANANRGPTS--PSVTAI--ELIPS 670
Query: 684 LTSVQN-QAMPSLTTSHLQTVPSLVHSTFQSMPNLISDSPQAMASLASDHPQAGPSLMSG 742
+T+ +N ++P + L+ S S + IS S ++ +P GPS +S
Sbjct: 671 VTNPENLPSLPDIPPIQLEDAGS--SSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALSP 728
Query: 743 HTQAVPSLATCPLQSIPPVSDMQPETGSSSSSGRTSGSLCPRDGAD-------PSLENAL 795
+ + + T P++ PP + GS SSGRT+ +D P E+ +
Sbjct: 729 GSSGLSNSHT-PVR--PPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTEDEI 785
Query: 796 CK----VKLEEPIN-------LSVKKPPLAPVVSTSTALQ 824
C VK E+ + LS + L P +ST+ L+
Sbjct: 786 CSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLE 825
>gi|5032179 tripartite motif-containing 28 protein [Homo sapiens]
Length = 835
Score = 166 bits (420), Expect = 1e-40
Identities = 92/283 (32%), Positives = 149/283 (52%), Gaps = 22/283 (7%)
Query: 5 CSECKEKRAAHILCTYCNRWLCSSCTEEHR-------HSPVPGGPFFPRAQKGSPGVNGG 57
C+ C++ A C C+ LC +C E H+ H+ GP R
Sbjct: 153 CTSCEDNAPATSYCVECSEPLCETCVEAHQRVKYTKDHTVRSTGPAKSR----------- 201
Query: 58 PGDFTLYCPLHTQEVLKLFCETCDMLTCHSCLVVEHKEHRCRHVEEVLQNQRMLLEGVTT 117
G+ T+YC +H E L LFCE+CD LTC C + HK+H+ + +E+ ++NQR LL +
Sbjct: 202 DGERTVYCNVHKHEPLVLFCESCDTLTCRDCQLNAHKDHQYQFLEDAVRNQRKLLASLVK 261
Query: 118 QVAHKKSSLQTSAKQIEDRIFEVKHQHRKVENQIKMAKMVLMNELNKQANGLIEELEGIT 177
++ K ++LQ S K++ I +V ++V+ +KMA + +M ELNK+ L+ + + +T
Sbjct: 262 RLGDKHATLQKSTKEVRSSIRQVSDVQKRVQVDVKMAILQIMKELNKRGRVLVNDAQKVT 321
Query: 178 NERKRKLEQQLQSIMVLNRQFEHVQNFINWAVCSKTSVPFLFSKELIVFQMQRLLETSCN 237
++ +LE+Q ++ + + EH+ F +WA+ S + L SK+LI FQ+ R L+
Sbjct: 322 EGQQERLERQHWTMTKIQKHQEHILRFASWALESDNNTALLLSKKLIYFQLHRALKMI-- 379
Query: 238 TDPGSP-WSIRFTWEPNFWTKQLASLGCITTE-GGQMSRADAP 278
DP P ++F W+ N WTK + G I E G S AP
Sbjct: 380 VDPVEPHGEMKFQWDLNAWTKSAEAFGKIVAERPGTNSTGPAP 422
Score = 118 bits (295), Expect = 4e-26
Identities = 97/332 (29%), Positives = 155/332 (46%), Gaps = 44/332 (13%)
Query: 858 KIPYVRLERLKICAASSGEMPVFKLKPQKNDQDGSFLLIIECGTESSS------------ 905
K+P V LERL + + + PVFK+ P +D + L++IE G +++
Sbjct: 484 KVPRVSLERLDLDLTADSQPPVFKVFPGSTTEDYN-LIVIERGAAAAATGQPGTAPAGTP 542
Query: 906 -------MSIKVSQDRLSEATQAP--GLEGRKVTVTSLAGQRPPEVEG---------TSP 947
M+I V ++ A AP EG + +A P EG TS
Sbjct: 543 GAPPLAGMAI-VKEEETEAAIGAPPTATEGPETKPVLMALAEGPGAEGPRLASPSGSTSS 601
Query: 948 EEHRLIPRTPGAKKGPPAPIENE-DFCAVCLNGGELLCCDRCPKVFHLSCHVPALLSFPG 1006
+ P A G P +++ C VC G+L+ C++C FHL CH+PAL PG
Sbjct: 602 GLEVVAPEGTSAPGGGPGTLDDSATICRVCQKPGDLVMCNQCEFCFHLDCHLPALQDVPG 661
Query: 1007 GEWVCTLCRSLTQPEM-EYDCENACYNQPGMRASPGLSMYDQKKCEKLVLSLCCNNLSLP 1065
EW C+LC L P++ E D + LS +Q+KCE+++L+L C+ P
Sbjct: 662 EEWSCSLCHVL--PDLKEEDGSLSLDGADSTGVVAKLSPANQRKCERVLLALFCHEPCRP 719
Query: 1066 FHEPVSPLARHYYQIIKRP---MDLSIIRRKLQKKDPAHYTTPEEVVSDVRLMFWNCAKF 1122
H+ LA + +P +DL++IR +LQ+K Y++P+E DV MF K
Sbjct: 720 LHQ----LATDSTFSLDQPGGTLDLTLIRARLQEKLSPPYSSPQEFAQDVGRMFKQFNKL 775
Query: 1123 NYPDSEVAEAGRCLEVFFEGWLKEIYPEKRFA 1154
++V ++ L+ FFE + E + + +F+
Sbjct: 776 TEDKADV-QSIIGLQRFFETRMNEAFGDTKFS 806
>gi|91176325 bromodomain adjacent to zinc finger domain, 2A [Homo
sapiens]
Length = 1905
Score = 96.7 bits (239), Expect = 1e-19
Identities = 70/231 (30%), Positives = 101/231 (43%), Gaps = 50/231 (21%)
Query: 969 NEDFCAVCLNGGE---LLCCDRCPKVFHLSCHVPALLSFPGGEWVCTLC----------- 1014
N+ C VC G LL CD C + H+ CH P + + P G+W CT+C
Sbjct: 1675 NKVTCLVCRKGDNDEFLLLCDGCDRGCHIYCHRPKMEAVPEGDWFCTVCLAQQVEGEFTQ 1734
Query: 1015 --------------------------RSLTQPEMEYDCENACYNQPGMRASPG--LSMYD 1046
R + E Y++ G+ S LSM +
Sbjct: 1735 KPGFPKRGQKRKSGYSLNFSEGDGRRRRVLLRGRESPAAGPRYSEEGLSPSKRRRLSMRN 1794
Query: 1047 QKK----CEKLVLSLCCNNLSLPFHEPVSP-LARHYYQIIKRPMDLSIIRRKLQKKDPAH 1101
CE +++ + ++ + PF EPV+P L Y +IIK PMD S +R +L +
Sbjct: 1795 HHSDLTFCEIILMEMESHDAAWPFLEPVNPRLVSGYRRIIKNPMDFSTMRERLLR---GG 1851
Query: 1102 YTTPEEVVSDVRLMFWNCAKFNYPDSEVAEAGRCLEVFFEGWLKEIYPEKR 1152
YT+ EE +D L+F NC FN DSEV +AG + FFE +E Y K+
Sbjct: 1852 YTSSEEFAADALLVFDNCQTFNEDDSEVGKAGHIMRRFFESRWEEFYQGKQ 1902
Score = 31.6 bits (70), Expect = 4.8
Identities = 58/230 (25%), Positives = 82/230 (35%), Gaps = 43/230 (18%)
Query: 299 QQEALSHPSHKFQSPAVCSSSV--CCSHCSPVSPSLKGQVP----PPSIHPAHSFRQPPE 352
+ ++L +H +PA+ S + S+ + SP+ P P S+ P H + P
Sbjct: 1152 ETDSLKVAAHASLNPALFSMKMELAGSNTTASSPARARGRPRKTKPGSMQPRH-LKSPV- 1209
Query: 353 MVPQQLGSLQCSALLPREKELACSPHPPKLLQPWLETQPP-VEQESTSQRLGQQLTSQPV 411
+ S Q A L E +L P LQ L++ +EQE + LGQ
Sbjct: 1210 ---RGQDSEQPQAQLQPEAQLHAPAQPQPQLQLQLQSHKGFLEQEGSPLSLGQS------ 1260
Query: 412 CIVPPQDVQQGAHAQPTLQTPS------IQVQFGHHQKLKLSHFQQQPQQQLPPP----- 460
D+ Q A QT S V KL QP ++ P
Sbjct: 1261 ----QHDLSQSAFLSWLSQTQSHSSLLSSSVLTPDSSPGKLDPAPSQPPEEPEPDEAESS 1316
Query: 461 PPP----------LPHPPPPLPPPPQQPHPPLPPSQHLASSQHESPPGPA 500
P P +P P PPP P P Q LASS+ + P A
Sbjct: 1317 PDPQALWFNISAQMPCNAAPTPPPAVSEDQPTPSPQQLASSKPMNRPSAA 1366
>gi|134133279 SP140 nuclear body protein-like [Homo sapiens]
Length = 580
Score = 90.1 bits (222), Expect = 1e-17
Identities = 61/183 (33%), Positives = 87/183 (47%), Gaps = 12/183 (6%)
Query: 967 IENEDFCAVCLNGGELLCCDRCPKVFHLSCHVPALLSFPGGEWVCTLCRSLTQPEMEYDC 1026
+ N D C VC +GGEL CCD C +VFH CH+P + S W C CR P + C
Sbjct: 400 MRNLDECEVCRDGGELFCCDTCSRVFHEDCHIPPVES-EKTPWNCIFCRMKESPGSQQCC 458
Query: 1027 ENACYNQPGMRASPGLSMYDQKKCEKLVLSL-CCNNLSLPFHEPVSPLARHYYQIIKRPM 1085
+ + + M +Q KCE L+L + CC+ S P R Q +K PM
Sbjct: 459 QESEVLERQMCPE------EQLKCEFLLLKVYCCSESSFFAKIPYYYYIREACQGLKEPM 512
Query: 1086 DLSIIRRKLQKKDPAHYTTPEEVVSDVRLMFWNCAKFNYPDSEVAEAGRCLEVFFEGWLK 1145
L I+++L + Y E V D+RL+F N + +Y + + G LE FE K
Sbjct: 513 WLDKIKKRLNEHG---YPQVEGFVQDMRLIFQN-HRASYKYKDFGQMGLRLEAEFEKDFK 568
Query: 1146 EIY 1148
E++
Sbjct: 569 EVF 571
>gi|217330601 SP140 nuclear body protein isoform 1 [Homo sapiens]
Length = 867
Score = 88.6 bits (218), Expect = 3e-17
Identities = 60/183 (32%), Positives = 86/183 (46%), Gaps = 12/183 (6%)
Query: 967 IENEDFCAVCLNGGELLCCDRCPKVFHLSCHVPALLSFPGGEWVCTLCRSLTQPEMEYDC 1026
+ N D C VC +GGEL CCD C +VFH CH+P + W C CR P + C
Sbjct: 687 MRNLDECEVCRDGGELFCCDTCSRVFHEDCHIPP-VEAERTPWNCIFCRMKESPGSQQCC 745
Query: 1027 ENACYNQPGMRASPGLSMYDQKKCEKLVLSL-CCNNLSLPFHEPVSPLARHYYQIIKRPM 1085
+ + + M +Q KCE L+L + CC+ S P R Q +K PM
Sbjct: 746 QESEVLERQMCPE------EQLKCEFLLLKVYCCSESSFFAKIPYYYYIREACQGLKEPM 799
Query: 1086 DLSIIRRKLQKKDPAHYTTPEEVVSDVRLMFWNCAKFNYPDSEVAEAGRCLEVFFEGWLK 1145
L I+++L + Y E V D+RL+F N + +Y + + G LE FE K
Sbjct: 800 WLDKIKKRLNEHG---YPQVEGFVQDMRLIFQN-HRASYKYKDFGQMGFRLEAEFEKNFK 855
Query: 1146 EIY 1148
E++
Sbjct: 856 EVF 858
>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
sapiens]
Length = 1124
Score = 85.5 bits (210), Expect = 3e-16
Identities = 137/562 (24%), Positives = 197/562 (35%), Gaps = 114/562 (20%)
Query: 266 TTEGGQMSRADAPAYGGLQGSSPFYQSHQSPVAQQEALSHPSHKFQSPAVCSSSVCCSHC 325
TTE +R A GGLQ + S + A S PS + A +H
Sbjct: 217 TTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAP-------AHP 269
Query: 326 SPVSPSLKGQVPPPSIHPAHSFRQPPEMVPQQLGSLQCSALL---PREKELACSPHPPKL 382
S P + PP + P P LG L S L P + P P
Sbjct: 270 SQPKPKGLQALRPPQVTPPRKDAAPA------LGPLSSSPLATPSPSGTKARPVPPPDNA 323
Query: 383 LQPWLETQPPVEQESTSQRLGQQLTSQPVCIVPPQDVQQGAHAQPTLQT-PSIQVQFGHH 441
P T PP +T P+ + PP A P+LQT PS
Sbjct: 324 ATPLPATLPPSPPLAT-----------PLPLAPPSP-----SAPPSLQTLPS-------- 359
Query: 442 QKLKLSHFQQQPQQQLPPPPPPLPHPPPPLPPPPQQPHPPLPPSQHLASSQHESPPGPAC 501
P P PP PP PP Q PP+ L S ++PP P
Sbjct: 360 -----------PPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLA 408
Query: 502 SQNMDIMHHKFELEEMQKDLELLLQAQQPSLQLSQ---TKSPQHLQQTIVGQINYIVRQP 558
+ L+ P+LQ + T SP+ Q ++
Sbjct: 409 LSS----------------LQATTSLGSPTLQATHSFLTMSPRQTQASLTS-------PS 445
Query: 559 APVQSQSQEETLQATDEPPASQGSKPALPLDKNTAAALPQASGEETPLSVPPVDSTIQHS 618
P + LQA PAS + +L P S +PL++ P+ +
Sbjct: 446 RPASTPPDSPPLQAPLSLPASPPLQTSLS---------PAVSPLSSPLTIHPLQAL---- 492
Query: 619 SPNVVRKHSTSLSIMGFSNTLEMELSSTRLERPLEPQIQSVSNLTAGAPQAVPSLLSAPP 678
+SL+ S++ + LSS + P +++ S+L + Q P+ L+ PP
Sbjct: 493 ---------SSLA----SHSPQAPLSSL-----IMPPLETQSSLAPPSLQTPPASLTTPP 534
Query: 679 --KMVSSLTSVQNQAMPSLTTSHLQTVPSLVHSTFQSMPN-LISDSPQAMASLASDHPQA 735
+ S A LTT HL+T P Q+ P+ L + P+ +S+A+ PQA
Sbjct: 535 LENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQA 594
Query: 736 GPSLMSGHTQAVPSLATCPLQSIPPVS--DMQPETGSSSSSGRTSGSLCPRDGADPSLEN 793
P+L S Q +PS PL + PP + + + S S L P P N
Sbjct: 595 PPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPN 654
Query: 794 ALCKVKLEEPINLSVKKPPLAP 815
AL L+ P + P AP
Sbjct: 655 ALAVHLLQAPFSPPPSPPVQAP 676
Score = 73.2 bits (178), Expect = 1e-12
Identities = 137/573 (23%), Positives = 190/573 (33%), Gaps = 97/573 (16%)
Query: 327 PVSPSLKGQVP-PPSIHPAHSFRQPPEMVPQQLGSLQCSALLPREKELACSPHPPKLLQP 385
PV P P P ++ P+ P + P + LP S PP + P
Sbjct: 316 PVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTP 375
Query: 386 WLETQPPVEQESTSQRLGQQLTSQPVCIVPPQDVQQGAHAQPTLQTPSIQVQFGHHQKLK 445
++ PP Q ++ LTS + P A +L +P++Q H L
Sbjct: 376 PMQA-PPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQAT---HSFLT 431
Query: 446 LSHFQQQPQQQLPPPPPPLPHPPPPLPPPPQQP-HPPLP-----------------PSQH 487
+S Q Q P P P PPL P P PPL P Q
Sbjct: 432 MSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQA 491
Query: 488 LASSQHESPPGPACSQNMDIMHHKFELEEMQKD----------LELLLQAQQPSLQLSQT 537
L+S SP P S M + + L LE L P LQ +
Sbjct: 492 LSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASA 551
Query: 538 K-SPQHLQQTIVGQINYIVRQPAPVQSQSQEETLQATDEPPAS---------QG--SKPA 585
+ HL+ + P+P+ + E PP + QG S P
Sbjct: 552 PLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPPL 611
Query: 586 LPL-----DKNTAAALPQASGEETPLSVPPVD--STIQHSSPNVVRKHSTSLSIMGFSNT 638
PL ALP +P + PP+ +T +PN + H L FS
Sbjct: 612 SPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPNALAVH---LLQAPFSPP 668
Query: 639 LEMELSSTRLERPLEPQIQSVSNLTAGAPQAVPSLLSAPPKMV----------SSLTSVQ 688
S ++ P P + +A P P L+APP V S +
Sbjct: 669 -----PSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPP 723
Query: 689 NQAMPSLTTSHLQTVPS---------------LVHSTFQSMPNLISDSPQA---MASLAS 730
QA P L LQ PS V + P + SP A M+ LA
Sbjct: 724 PQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAK 783
Query: 731 DHPQAGPSLMSGHTQAVPSLATCPLQSIPPVSDMQPETGSSSSSGRTSGSLCPRDGADPS 790
PQA P+L + QA+PS PP S S S+S S P A P
Sbjct: 784 PPPQAPPALATPPLQALPS---------PPASFPGQAPFSPSASLPMSPLATPPPQAPPV 834
Query: 791 LENALCKVKLEEPINLSVKKPPLAPVVSTSTAL 823
L L +V P + +++ P P T++
Sbjct: 835 LAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSV 867
Score = 50.8 bits (120), Expect = 8e-06
Identities = 62/222 (27%), Positives = 79/222 (35%), Gaps = 24/222 (10%)
Query: 287 SPFYQSHQSPVAQQEALSHPSHKFQSPAVCSSSVCCSHCSP--VSPSLKGQVPPPSIHPA 344
+PF PV Q S P+ SP V S+ S P +P L+ PP+ P
Sbjct: 663 APFSPPPSPPV--QAPFSPPA----SPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPM 716
Query: 345 HSFRQPPEMVPQQLGS--LQCSALLPREKELACSPHPPKLLQPWLETQPPVEQESTSQRL 402
PP P L + LQ P ++ S PP + P L PP++ +
Sbjct: 717 SPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAA-PPLQVPPSPPA- 774
Query: 403 GQQLTSQPVCIVPPQDVQQGAHAQPTLQTPSIQVQFGHHQKLKLSHFQQQPQQQLPPPP- 461
L P+ PPQ A P L TP +Q P LP P
Sbjct: 775 --SLPMSPLAKPPPQ-------APPALATPPLQALPSPPASFP-GQAPFSPSASLPMSPL 824
Query: 462 -PPLPHPPPPLPPPPQQPHPPLPPSQHLASSQHESPPGPACS 502
P P PP L P Q P P S L + + PGP S
Sbjct: 825 ATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTS 866
Score = 50.4 bits (119), Expect = 1e-05
Identities = 79/305 (25%), Positives = 101/305 (33%), Gaps = 47/305 (15%)
Query: 321 CCSHCSPVSPSLKGQVPPPSIHPAHSFRQPPEMVPQQLGSLQCSAL-LPREKELACSPH- 378
C + C +P PPP S PP P L S L P LA P
Sbjct: 563 CPAPCPLQAPPSPLTTPPPET--PSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQ 620
Query: 379 -PPKLLQPWLETQPPVEQESTSQRLGQQLTSQPVCIVPPQDVQQGAHAQPTLQTPSIQVQ 437
PP L P L+ P L P + + Q + P +P +Q
Sbjct: 621 APPXLALPPLQAPPSPPASPPLSPLATPSPQAPNALAV--HLLQAPFSPPP--SPPVQAP 676
Query: 438 FGHHQKLKLSHFQQQPQQ----------QLPPPPPPLPHPPPPLPPPPQQPHPPLPPSQH 487
F +S P Q Q+PP PP P P PPPQ P P
Sbjct: 677 FSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPP------- 729
Query: 488 LASSQHESPPGPACSQNMDIMHHKFELEEMQKDLELLLQAQQPSLQLSQTKSPQHLQQTI 547
LA+ + PP P S M + LL A P LQ+ + P L
Sbjct: 730 LAAPPLQVPPSPPASPPMS------PSATPPPRVPPLLAA--PPLQVPPS-PPASL---- 776
Query: 548 VGQINYIVRQPAPVQSQSQEETLQATDEPPAS-QGSKPALPLDKNTAAALPQASGEETPL 606
++ + + P LQA PPAS G P P +A+LP + P
Sbjct: 777 --PMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSP-----SASLPMSPLATPPP 829
Query: 607 SVPPV 611
PPV
Sbjct: 830 QAPPV 834
Score = 33.5 bits (75), Expect = 1.3
Identities = 53/214 (24%), Positives = 64/214 (29%), Gaps = 32/214 (14%)
Query: 292 SHQSPVAQQEALSHPSHKFQSPAVCSSSVCCSHCSP--VSPSLKGQVPPPSIHPAHSFRQ 349
S P L P SP + S+ P +P L+ PP+ P
Sbjct: 693 SQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSAT 752
Query: 350 PPEMVPQQLGS--LQCSALLPREKELACSPHPPKLLQPWLETQPPVEQESTSQRLGQQ-- 405
PP VP L + LQ P ++ PP P L T P S Q
Sbjct: 753 PPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAP 812
Query: 406 ------LTSQPVCIVPPQ----------DVQQGAHAQPTLQTPSIQVQFGHHQKLKLSHF 449
L P+ PPQ V A PTLQ P G +
Sbjct: 813 FSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVS---- 868
Query: 450 QQQPQQQLP----PPPPPLPHPPPPLPPPPQQPH 479
P+ L PPPPP P L P H
Sbjct: 869 --GPRLTLALAPGPPPPPSRSPSSTLSGPDLAGH 900
>gi|190343006 SP110 nuclear body protein isoform c [Homo sapiens]
Length = 713
Score = 82.0 bits (201), Expect = 3e-15
Identities = 63/207 (30%), Positives = 90/207 (43%), Gaps = 13/207 (6%)
Query: 941 EVEGTSPEEHRLIPRTPGAKKGPPAPIENEDFCAVCLNGGELLCCDRCPKVFHLSCHVPA 1000
E +G + + + R G G +N D C VC GG+LLCC CP+VFH CH+P
Sbjct: 505 EGKGRNAKNWKRNIRCEGMTLGELLKRKNSDECEVCCQGGQLLCCGTCPRVFHEDCHIPP 564
Query: 1001 LLSFPGGEWVCTLCRSLTQPEMEYDCENACYNQPGMRASPGLSMYDQKKCEKLVLSLCCN 1060
+ W CT CR + + C + + DQ KCE L+L C+
Sbjct: 565 -VEAKRMLWSCTFCR-MKRSSGSQQCHHV-----SKTLERQMQPQDQLKCEFLLLKAYCH 617
Query: 1061 NLSLPFHEPVSPLARHYYQIIKRPMDLSIIRRKLQKKDPAHYTTPEEVVSDVRLMFWNCA 1120
S F + R Y + + M L +++ +L T V D+RLMF N
Sbjct: 618 PQS-SFFTGIPFNIRDYGEPFQEAMWLDLVKERL----ITEMYTVAWFVRDMRLMFRNHK 672
Query: 1121 KFNYPDSEVAEAGRCLEVFFEGWLKEI 1147
F Y S+ + G LE FE LK++
Sbjct: 673 TF-YKASDFGQVGLDLEAEFEKDLKDV 698
Score = 32.3 bits (72), Expect = 2.8
Identities = 35/143 (24%), Positives = 55/143 (38%), Gaps = 18/143 (12%)
Query: 457 LPPPPPPLPHPPPPLPPPPQQPHPPLPPSQHLASSQHESPP----------GPACSQNMD 506
LPPP PP P P P + + L+ S S P G + S D
Sbjct: 139 LPPPQPPQPSCSPCAPRVSEPGTSSQQSDEILSESPSPSDPVLPLPALIQEGRSTSVTND 198
Query: 507 IMHHKFELEEMQKDLELLL----QAQQPSL--QLSQTKSPQHLQQTIVGQINYIVRQPAP 560
+ K EE +++ LL Q +L Q+ + PQ + + +G + I R +P
Sbjct: 199 KLTSKMNAEEDSEEMPSLLTSTVQVASDNLIPQIRDKEDPQEMPHSPLGSMPEI-RDNSP 257
Query: 561 VQSQSQEETLQATDEPPASQGSK 583
+ EE + + P +G K
Sbjct: 258 -EPNDPEEPQEVSSTPSDKKGKK 279
>gi|122939208 nuclear antigen Sp100 isoform 1 [Homo sapiens]
Length = 885
Score = 79.3 bits (194), Expect = 2e-14
Identities = 66/216 (30%), Positives = 98/216 (45%), Gaps = 30/216 (13%)
Query: 949 EHRLIPRTPGAKKG-----------PPAPIENEDFCAVCLNGGELLCCDRCPKVFHLSCH 997
E++ +P P +K P P EN + C VC G L CCD CP+ FH CH
Sbjct: 671 ENKFLPEPPSTRKKRILESHNNTLVDPCP-ENSNICEVCNKWGRLFCCDTCPRSFHEHCH 729
Query: 998 VPALLSFPGGEWVCTLCRSLTQPEMEYDCENACYNQPGMRASPGLSMY----DQKKCEKL 1053
+P+ + W C CR T E C +Q G + S L +Q KCE L
Sbjct: 730 IPS-VEANKNPWSCIFCRIKTIQER---CPE---SQSGHQESEVLMRQMLPEEQLKCEFL 782
Query: 1054 VLSLCCNNLSLPF-HEPVSPLARHYYQIIKRPMDLSIIRRKLQKKDPAHYTTPEEVVSDV 1112
+L + C++ S F EP R Q ++PM L+ ++ L ++ YT E V D+
Sbjct: 783 LLKVYCDSKSCFFASEPY--YNREGSQGPQKPMWLNKVKTSLNEQ---MYTRVEGFVQDM 837
Query: 1113 RLMFWNCAKFNYPDSEVAEAGRCLEVFFEGWLKEIY 1148
RL+F N +F Y + + G ++ FE + I+
Sbjct: 838 RLIFHNHKEF-YREDKFTRLGIQVQDIFEKNFRNIF 872
>gi|84993742 tripartite motif-containing 71 [Homo sapiens]
Length = 868
Score = 79.0 bits (193), Expect = 3e-14
Identities = 57/264 (21%), Positives = 110/264 (41%), Gaps = 19/264 (7%)
Query: 5 CSECKEKRAAHILCTYCNRWLCSSCTEEHRHSP------VPGGPFFPRAQKGSPGVNGGP 58
CS C E AA C C LC +C H+ + GP P A + + GP
Sbjct: 199 CSSCDEGNAASSRCLDCQEHLCDNCVRAHQRVRLTKDHYIERGPPGPGAAAAAQQLGLGP 258
Query: 59 G----DFTL---------YCPLHTQEVLKLFCETCDMLTCHSCLVVEHKEHRCRHVEEVL 105
F++ +C H EVL L+C+TC + C C + H H +++E L
Sbjct: 259 PFPGPPFSILSVFPERLGFCQHHDDEVLHLYCDTCSVPICRECTMGRHGGHSFIYLQEAL 318
Query: 106 QNQRMLLEGVTTQVAHKKSSLQTSAKQIEDRIFEVKHQHRKVENQIKMAKMVLMNELNKQ 165
Q+ R L + + ++Q S +Q + +V+ + + V++++K L ++
Sbjct: 319 QDSRALTIQLLADAQQGRQAIQLSIEQAQTVAEQVEMKAKVVQSEVKAVTARHKKALEER 378
Query: 166 ANGLIEELEGITNERKRKLEQQLQSIMVLNRQFEHVQNFINWAVCSKTSVPFLFSKELIV 225
L+ ++E I + + L Q++ + + E + + + ++ L +++ ++
Sbjct: 379 ECELLWKVEKIRQVKAKSLYLQVEKLRQNLNKLESTISAVQQVLEEGRALDILLARDRML 438
Query: 226 FQMQRLLETSCNTDPGSPWSIRFT 249
Q+Q L P + FT
Sbjct: 439 AQVQELKTVRSLLQPQEDDRVMFT 462
>gi|224548923 tripartite motif-containing 45 isoform 2 [Homo
sapiens]
Length = 562
Score = 77.8 bits (190), Expect = 6e-14
Identities = 61/255 (23%), Positives = 105/255 (41%), Gaps = 26/255 (10%)
Query: 5 CSECKEKRAAHILCTYCNRWLCSSCTEEHR-------HSPVPGGPFFPRAQKGSPGVNGG 57
C C + R C C LC C + HR H+ V ++ G P
Sbjct: 135 CDLCND-REVEKRCQTCKANLCHFCCQAHRRQKKTTYHTMVDLKDLKGYSRIGKP----- 188
Query: 58 PGDFTLYCPLHTQEVLKLFCETCDMLTCHSCLVVEHKEHRCRHVEEVLQNQR----MLLE 113
+ CP+H E L+LFCE CD C C+V EH+EH C V+ LL+
Sbjct: 189 -----ILCPVHPAEELRLFCEFCDRPVCQDCVVGEHREHPCDFTSNVIHKHGDSVWELLK 243
Query: 114 GVTTQVAHKKSSLQTSAKQIEDRIFEVKHQHRKVENQIKMAKMVLMNELNKQANGLIEEL 173
G V +L+ + QI ++ + V ++ + + + + L+++L
Sbjct: 244 GTQPHV----EALEEALAQIHIINSALQKRVEAVAADVRTFSEGYIKAIEEHRDKLLKQL 299
Query: 174 EGITNERKRKLEQQLQSIMVLNRQFEHVQNFINWAVCSKTSVPFLFSKELIVFQMQRLLE 233
E I +++ L+ Q + L F + S + + L +K ++V ++++L +
Sbjct: 300 EDIRAQKENSLQLQKAQLEQLLADMRTGVEFTEHLLTSGSDLEILITKRVVVERLRKLNK 359
Query: 234 TSCNTDPGSPWSIRF 248
+T PG IRF
Sbjct: 360 VQYSTRPGVNDKIRF 374
>gi|224548921 tripartite motif-containing 45 isoform 1 [Homo
sapiens]
Length = 580
Score = 77.8 bits (190), Expect = 6e-14
Identities = 61/255 (23%), Positives = 105/255 (41%), Gaps = 26/255 (10%)
Query: 5 CSECKEKRAAHILCTYCNRWLCSSCTEEHR-------HSPVPGGPFFPRAQKGSPGVNGG 57
C C + R C C LC C + HR H+ V ++ G P
Sbjct: 135 CDLCND-REVEKRCQTCKANLCHFCCQAHRRQKKTTYHTMVDLKDLKGYSRIGKP----- 188
Query: 58 PGDFTLYCPLHTQEVLKLFCETCDMLTCHSCLVVEHKEHRCRHVEEVLQNQR----MLLE 113
+ CP+H E L+LFCE CD C C+V EH+EH C V+ LL+
Sbjct: 189 -----ILCPVHPAEELRLFCEFCDRPVCQDCVVGEHREHPCDFTSNVIHKHGDSVWELLK 243
Query: 114 GVTTQVAHKKSSLQTSAKQIEDRIFEVKHQHRKVENQIKMAKMVLMNELNKQANGLIEEL 173
G V +L+ + QI ++ + V ++ + + + + L+++L
Sbjct: 244 GTQPHV----EALEEALAQIHIINSALQKRVEAVAADVRTFSEGYIKAIEEHRDKLLKQL 299
Query: 174 EGITNERKRKLEQQLQSIMVLNRQFEHVQNFINWAVCSKTSVPFLFSKELIVFQMQRLLE 233
E I +++ L+ Q + L F + S + + L +K ++V ++++L +
Sbjct: 300 EDIRAQKENSLQLQKAQLEQLLADMRTGVEFTEHLLTSGSDLEILITKRVVVERLRKLNK 359
Query: 234 TSCNTDPGSPWSIRF 248
+T PG IRF
Sbjct: 360 VQYSTRPGVNDKIRF 374
>gi|4557291 autoimmune regulator isoform 1 [Homo sapiens]
Length = 545
Score = 75.5 bits (184), Expect = 3e-13
Identities = 36/92 (39%), Positives = 47/92 (51%), Gaps = 2/92 (2%)
Query: 953 IPRTPGAKKGPPAPIENEDFCAVCLNGGELLCCDRCPKVFHLSCHVPALLSFPGGEWVCT 1012
+P P +NED CAVC +GGEL+CCD CP+ FHL+C P L P G W C+
Sbjct: 279 VPAPLALPSDPQLHQKNEDECAVCRDGGELICCDGCPRAFHLACLSPPLREIPSGTWRCS 338
Query: 1013 LCRSLTQPEMEYDCENACYNQPGMRA--SPGL 1042
C T E++ E +P + PGL
Sbjct: 339 SCLQATVQEVQPRAEEPRPQEPPVETPLPPGL 370
Score = 41.6 bits (96), Expect = 0.005
Identities = 19/48 (39%), Positives = 22/48 (45%)
Query: 973 CAVCLNGGELLCCDRCPKVFHLSCHVPALLSFPGGEWVCTLCRSLTQP 1020
C VC +G ++L C C FH CH PA S PG C C P
Sbjct: 434 CGVCGDGTDVLRCTHCAAAFHWRCHFPAGTSRPGTGLRCRSCSGDVTP 481
>gi|4557293 autoimmune regulator isoform 2 [Homo sapiens]
Length = 348
Score = 74.7 bits (182), Expect = 5e-13
Identities = 34/77 (44%), Positives = 44/77 (57%), Gaps = 2/77 (2%)
Query: 968 ENEDFCAVCLNGGELLCCDRCPKVFHLSCHVPALLSFPGGEWVCTLCRSLTQPEMEYDCE 1027
+NED CAVC +GGEL+CCD CP+ FHL+C P L P G W C+ C T E++ E
Sbjct: 97 KNEDECAVCRDGGELICCDGCPRAFHLACLSPPLREIPSGTWRCSSCLQATVQEVQPRAE 156
Query: 1028 NACYNQPGMRA--SPGL 1042
+P + PGL
Sbjct: 157 EPRPQEPPVETPLPPGL 173
Score = 41.6 bits (96), Expect = 0.005
Identities = 19/48 (39%), Positives = 22/48 (45%)
Query: 973 CAVCLNGGELLCCDRCPKVFHLSCHVPALLSFPGGEWVCTLCRSLTQP 1020
C VC +G ++L C C FH CH PA S PG C C P
Sbjct: 237 CGVCGDGTDVLRCTHCAAAFHWRCHFPAGTSRPGTGLRCRSCSGDVTP 284
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 74.3 bits (181), Expect = 6e-13
Identities = 142/619 (22%), Positives = 222/619 (35%), Gaps = 127/619 (20%)
Query: 265 ITTEGGQMSRADAPAYGG-LQGSSPFYQSHQSPVAQQEALSHPSHKFQSPAVCSSSVCCS 323
I+++ + ++ P G +QG + Q+ + + Q S P K Q+ V SV S
Sbjct: 239 ISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTK-QADIVRGESVKPS 297
Query: 324 HCSPVSPSLKGQVP--PPSIHPAHSFRQPPEMVPQQLGSLQCSALLPREKELACSPHPPK 381
SP P ++ P PP+ P H QP P S L + + PP
Sbjct: 298 LPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPG 357
Query: 382 LLQPWLE----TQPPVEQ----ESTSQRLGQQLTSQPVCI--VPPQD-------VQQGAH 424
+P + +PP +Q + +S++ G + +QP + P Q QQ
Sbjct: 358 TTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGT 417
Query: 425 AQPTLQTPSIQV-----------------------QFGHHQKLKLSHFQQQPQQQLPPPP 461
+P Q P +Q Q G + +P QLP P
Sbjct: 418 PKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPA 477
Query: 462 PPLPHPPPPLPPPPQQPHPPLPPSQHLASSQ-HESPPGPACSQNMDIMHHKFELEEMQKD 520
P P P P PPPQQP PPSQ S++ PGPA
Sbjct: 478 KPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPA-------------------- 517
Query: 521 LELLLQAQQPSLQLSQTKSPQHLQQTIVGQINYIVRQPAPVQSQSQEETLQATDEPPASQ 580
+PS Q + P Q G +QP+P + +Q+ T +P +
Sbjct: 518 --------KPSPQQPGSTKPPSQQP---GSAKPSAQQPSPAKPSAQQST-----KPVSQT 561
Query: 581 GS-KPALPLDKNTAAALPQASGEETPLSVPPVDSTI-------QHSSPNVVRKHSTSL-S 631
GS KP P + +A P + G P ++ P+ +T + ++ N + T++ S
Sbjct: 562 GSGKPLQPPTVSPSAKQPPSQG--LPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCS 619
Query: 632 IMGF------SNTLEMELSSTRLERPLEPQIQSVSNLTAGAPQAVPSLLSAPPKMVSSL- 684
+ GF + E + +++R L + V + +PQ P L +AP S++
Sbjct: 620 LCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPS----SPQ--PKLKTAPVTTTSAVS 673
Query: 685 --------TSVQNQAMPSLTTSHL----QTVPSLVHSTFQSMPNLISDSPQAMASLASDH 732
TS + A P S + P + T P+ + P SL+
Sbjct: 674 KSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPA 733
Query: 733 PQAGPSLMSGHTQAVPSLATCPLQSIPPVSDMQPETGSSSSSGRTSGSLCPRDGADPSLE 792
P PS+ S +A P P Q ++P T SSS T+ P E
Sbjct: 734 PPKEPSVPSEQDKA-PVADDKPKQP----KMVKPTTDLVSSSSATTKPDIPSSKVQSQAE 788
Query: 793 NALCKVKLEEPINLSVKKP 811
K P+ KP
Sbjct: 789 E-----KTTPPLKTDSAKP 802
Score = 55.1 bits (131), Expect = 4e-07
Identities = 158/696 (22%), Positives = 228/696 (32%), Gaps = 131/696 (18%)
Query: 333 KGQVPPPSIHPAHSFRQPPEMVPQQLGSLQCSALLPREKELACSPHPPKLLQPWLETQPP 392
K Q P I +QPP+ +P+Q G + + S P K+ T P
Sbjct: 198 KEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIKSQPPGTGKP 257
Query: 393 VEQESTSQRLG------QQLTSQPVCIVPPQDVQQGAHAQPTLQTPS----IQVQFGHHQ 442
++ + + + Q+ S+P D+ +G +P+L +PS Q G
Sbjct: 258 IQGPTQTPQTDHAKLPLQRDASRPQ--TKQADIVRGESVKPSLPSPSKPPIQQPTPGKPP 315
Query: 443 KLKLSHFQQQPQQQLPPPPP-----PLPHPP----PPLPP-----PPQQP-HPPLPPSQH 487
+ H + QP PP P PL P PP+ P PP QP P PP+Q
Sbjct: 316 AQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQ 375
Query: 488 LASSQHES----------PPGPACSQNMDIMHHKFELEEMQKDLELLLQAQQPSLQLSQT 537
S + S PPG + K +++ L AQQP LQ S
Sbjct: 376 TGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPL---AQQPGLQ-SPA 431
Query: 538 KSPQHLQQTIVGQINYIVRQPAPVQSQSQE------ETLQATDEPPASQGSKPALPLDKN 591
K+P G V+QP P + +Q+ Q P SQ PA P +
Sbjct: 432 KAP--------GPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQ 483
Query: 592 TAAAL--PQASGEETPLSVPPVDSTIQHSSPNVVRKHSTSL-SIMGFSNTLEMELSSTRL 648
A PQ G P S P + P + S S S +
Sbjct: 484 PGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQ 543
Query: 649 ERPLEPQIQS----VSNLTAGAPQAVPSLLSAPPKMVSSLTSVQNQAMPSLTTSHLQTVP 704
P +P Q VS +G P PP + S +Q +P T
Sbjct: 544 PSPAKPSAQQSTKPVSQTGSGKP-------LQPPTVSPSAKQPPSQGLPKTICPLCNTTE 596
Query: 705 SLVHSTFQSMPNLISDSPQAMASLASDHPQ-------------------AGPSLMSGHTQ 745
L+H ++ N ++ + SL +P G L +
Sbjct: 597 LLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSS 656
Query: 746 AVPSLATCPLQSIPPVSDMQPETGSSSSSGRTSGSLCPRDGADPSLENALCKVKLEEPIN 805
P L T P+ + VS P+ +S P+ A P + + K EP
Sbjct: 657 PQPKLKTAPVTTTSAVSKSSPQPQQTS----------PKKDAAPKQDLS----KAPEP-- 700
Query: 806 LSVKKPPLAPVVSTSTALQQYQNPKECENFEQGALELDAKENQSIRAFNSEHKIPYVRLE 865
KKPP P+V T L + K + E +L A K P V E
Sbjct: 701 ---KKPP--PLVKQPT-LHGSPSAKAKQPPEADSLSKPAPP-----------KEPSVPSE 743
Query: 866 RLKICAASSGEMPVFKLKPQKNDQDGSFLLIIECGTESSSMSIKVSQDRLSEATQAPGLE 925
+ K A K K K + + L+ T + Q + E T P
Sbjct: 744 QDKAPVADD------KPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPP--- 794
Query: 926 GRKVTVTSLAGQRPPEVEGTSPEEHRLIPRTPGAKK 961
K + PP E SP + + IPR K
Sbjct: 795 -LKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSK 829
Score = 55.1 bits (131), Expect = 4e-07
Identities = 91/380 (23%), Positives = 135/380 (35%), Gaps = 42/380 (11%)
Query: 378 HPPKLLQPWLETQPPVEQESTSQRLGQQLTSQPVCIVPPQDVQQGAHAQPTLQTPSIQVQ 437
HPP + P EQ ST+ + Q P + G+ + +L P+
Sbjct: 2342 HPPSSVI----ALPMKEQLSTTYFTSGETFGQEK---PASQLPSGSPSVSSL--PAKPRP 2392
Query: 438 FGHHQKLKLSHFQQQPQQQLPPPPPPLPHPPPPLPPPPQQPHPPLPPSQHLASSQHESPP 497
F L +S P PPPPPP P PPPP PPP P P + P + L + +
Sbjct: 2393 FFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKLTVASPVTTA 2452
Query: 498 GPACSQNMDIMHHKFELEEMQKDLELLLQAQQPSLQLSQTKSPQHLQQTIVGQINYIVRQ 557
P + + L + + P + + P L T + +
Sbjct: 2453 TPLFDA-VTTLETTAVLRSNGLPVTRICTTAPPPVPPKPSSIPSGLVFTHRPEPSKPPIA 2511
Query: 558 PAPVQSQSQEETLQATDEPPASQGSKPALPLDKNTAAALPQASGEETPLSVPPVDSTIQH 617
P PV Q T + TD P G L L + L ++ + P P+
Sbjct: 2512 PKPVIPQLPTTTQKPTDIHPKPTG----LSLTSSMTLNLVTSADYKLPSPTSPLSPHSNK 2567
Query: 618 SSPNVVRKHSTSLSIMGFSNTLEMELSSTRLERPLEPQIQSVSNLTAGAPQAVPS--LLS 675
SSP + S SL+ E + T P P S S P PS L+S
Sbjct: 2568 SSP----RFSKSLT--------ETYVVITLPSEPGTPTDSSASQAITSWPLGSPSKDLVS 2615
Query: 676 APP--KMVSSLTSVQNQAMPSLT---TSHLQT---VPSLVHSTFQSMPNLISD------S 721
P +V +T+V+ T + LQT P S+FQ+ P ++ S
Sbjct: 2616 VEPVFSVVPPVTAVEIPISSEQTFYISGALQTFSATPVTAPSSFQAAPTSVTQFLTTEVS 2675
Query: 722 PQAMASLASDHPQAGPSLMS 741
+++ S P G S +S
Sbjct: 2676 KTEVSATRSTAPSVGLSSIS 2695
Score = 37.4 bits (85), Expect = 0.088
Identities = 101/566 (17%), Positives = 188/566 (33%), Gaps = 92/566 (16%)
Query: 326 SPVSPSLKGQVPPPSIHPAHSFRQPPEMVPQQLGSLQCSALLPREKELACSPHPPKLLQP 385
+P+ + PP S P S Q P + + + + EK + P + +
Sbjct: 962 APMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRT 1021
Query: 386 WLETQPPVEQESTSQRLGQQLTSQPVCIVPPQDVQQGAHAQPTLQTPSIQVQFGH----- 440
E +PP ++S S LT++P V P +++ + T ++ G
Sbjct: 1022 ETEKKPPPIKDSKS------LTAEPQKAVLPTKLEKSPKPESTCPLCKTELNIGSKDPPN 1075
Query: 441 --------HQKLKLSHFQQQPQ-------------------------QQLPPPPPPLPHP 467
+Q L F P +++PP P
Sbjct: 1076 FNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIRKMPPAPSGPKAS 1135
Query: 468 PPPLPPPPQQPHPPLPPSQHLASSQHESPPGPACSQNMDIMHHKFELEEMQKDLELLLQA 527
P P+P +PP L Q Q + K LE++++ L ++
Sbjct: 1136 PMPVPTESSSQKTAVPPQVKLVKKQ---------EQEVKTEAEKVILEKVKETLS--MEK 1184
Query: 528 QQPSLQLSQTKSPQHLQQTIVGQINYIVRQPAPVQSQ--SQEETLQATDEPPASQGSKPA 585
P + Q + L++ + ++P P + + +EE +++ ++ P + KP
Sbjct: 1185 IPPMVTTDQKQEESKLEKDKASALQ--EKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPT 1242
Query: 586 LPLDKNTAAALPQASGEETPLSVPPVDSTIQHSSPNVVRKHSTSLSIMGFSNTLEMELSS 645
P DK LP+A + S+P + + LE ++
Sbjct: 1243 -PEDKK---LLPEA----------------KTSAPEEQKHDLLKSQVQIAEEKLEGRVAP 1282
Query: 646 TRLERPLEPQIQSVSNLTAGAPQAVPSLLSAPPKMVSSLTSVQNQAMPSLTTSHLQTVPS 705
++ +PQ + + L +G PQ++P K +++ Q P T Q P
Sbjct: 1283 KTVQEGKQPQTK-MEGLPSGTPQSLPKEDDKTTK------TIKEQPQPPCTAKPDQVEPG 1335
Query: 706 LVHSTFQSMPNLISDSPQAMASLASDHPQAGPSLMSGHTQAVPSLATCPLQSIPPVSDMQ 765
+ + + S S Q + +S +PSL P + ++
Sbjct: 1336 KEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSL--IPTDEKDILKGLK 1393
Query: 766 PETGSSSSSGRTSGSLCPRDGADPSLENALCKVKLEEPINLSVKKPPLAPVVSTSTALQQ 825
++ S SS + L + S+ A +E +K VS Q
Sbjct: 1394 KDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADE----KSEKKTQPHEVSPEQPKDQ 1449
Query: 826 YQNPKECENFEQGALELDAKENQSIR 851
+ E E E + KE+Q R
Sbjct: 1450 EKTQSLSETLEITISEEEIKESQEER 1475
Score = 35.4 bits (80), Expect = 0.33
Identities = 47/243 (19%), Positives = 91/243 (37%), Gaps = 32/243 (13%)
Query: 458 PPPPPPLP----------HPPPPLPPP--PQQPHPPLPPSQHLASSQHESPPGPACSQNM 505
PPP PP P H P P PP P+ P LP + + H P G + + +M
Sbjct: 2483 PPPVPPKPSSIPSGLVFTHRPEPSKPPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLTSSM 2542
Query: 506 DIMHHKFELEEMQKDLELLLQAQQPSLQLSQTKSPQHLQQTIVGQINYIVRQPAPVQSQS 565
+ + + L + L KS +++ + ++ P+ + +
Sbjct: 2543 TL--------NLVTSADYKLPSPTSPLSPHSNKSSPRFSKSLT-ETYVVITLPSEPGTPT 2593
Query: 566 QEETLQATDEPPASQGSKPALPLDKNTAAALPQASGEETPLSVPP---VDSTIQH----- 617
QA P SK + ++ + +P + E P+S + +Q
Sbjct: 2594 DSSASQAITSWPLGSPSKDLVSVEP-VFSVVPPVTAVEIPISSEQTFYISGALQTFSATP 2652
Query: 618 -SSPNVVRKHSTSLSIMGFSNTLEMELSSTRLERPLEPQIQSVSNLTAGAPQAVPSLLSA 676
++P+ + TS++ + + E+S+TR P + S+S P A+ ++
Sbjct: 2653 VTAPSSFQAAPTSVTQFLTTEVSKTEVSATRSTAP-SVGLSSISITIPPEPLALDNIHLE 2711
Query: 677 PPK 679
P+
Sbjct: 2712 KPQ 2714
Score = 33.1 bits (74), Expect = 1.7
Identities = 80/378 (21%), Positives = 130/378 (34%), Gaps = 74/378 (19%)
Query: 286 SSPFYQSHQSPVAQQEALSHPSHKFQSPAVCSSSVCCSHCSPVSPSLKGQVPPPSIH--- 342
SSP + +PV A+S S + P S + +S + + + PPP +
Sbjct: 655 SSPQPKLKTAPVTTTSAVSKSSPQ---PQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPT 711
Query: 343 ----PAHSFRQPPEMVPQQLGSLQCSALLPREKELAC----SPHPPKLLQPWLE------ 388
P+ +QPPE + +P E++ A P PK+++P +
Sbjct: 712 LHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSS 771
Query: 389 -------------------TQPPVEQESTSQRLGQQLTSQPVCIV-------PPQDVQQG 422
T PP++ +S T + V P D +
Sbjct: 772 ATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKII 831
Query: 423 AHAQPTLQTPSIQVQFGHHQKL---KLSHFQQQPQQQLPPPPPPLPHPPPPLP------P 473
+H P+ ++ Q Q QK K + + P+ P P P PP P P P
Sbjct: 832 SHPGPSSESKG-QKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVP 890
Query: 474 PPQQPHPPLPPSQHLA---SSQHESPPGPACSQNMDIMHHKFEL--EEMQKDLELLLQAQ 528
PQQ P S+ + S ++P + + F + L+ A
Sbjct: 891 TPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAG 950
Query: 529 QPSLQLSQTKSPQHLQQTIVGQINYIVRQPAPVQSQSQEETLQATDE-PPASQGSKPALP 587
QP SQ+ ++Q PAP Q + + ++T + PPA S P
Sbjct: 951 QPGPH-SQSGPGAPMKQA-----------PAPSQPPTSQGPPKSTGQAPPAPAKSIPVKK 998
Query: 588 LDKNTAAALPQASGEETP 605
K AA + E+ P
Sbjct: 999 ETKAPAAEKLEPKAEQAP 1016
Score = 33.1 bits (74), Expect = 1.7
Identities = 30/108 (27%), Positives = 45/108 (41%), Gaps = 7/108 (6%)
Query: 355 PQQLGSLQCSALLPREKELACSPHPPKLLQPWLETQPPVEQESTSQRLGQQLTSQPVCIV 414
P G SA +P EK L P K+L P + PP ++ ++ Q+ S P +
Sbjct: 3629 PLSPGKALESAFVPYEKPLPDDISPQKVLHPDMAKVPPASPKTA--KMMQRSMSDPKPLS 3686
Query: 415 PPQDVQQGAHAQPTLQTPSIQVQFGHHQKLKLSHFQQQPQQQLPPPPP 462
P D A Q T + Q + S Q++ ++ LP PPP
Sbjct: 3687 PTADESSRAPFQYTEGYTT-----KGSQTMTSSGAQKKVKRTLPNPPP 3729
Score = 32.3 bits (72), Expect = 2.8
Identities = 28/107 (26%), Positives = 42/107 (39%), Gaps = 10/107 (9%)
Query: 387 LETQPPVEQEST------SQRLGQQLTSQPVCIVPPQDVQQGAHAQPTL--QTPSIQVQF 438
+E+Q +E+ T SQ + Q ++ + P Q ++ P L Q P+ Q
Sbjct: 3847 IESQHGIERPRTAPQTEFSQFIPPQTQTESQLVPPTSPYTQYQYSSPALPTQAPTSYTQQ 3906
Query: 439 GHHQKLKLSHFQQQPQQQLP--PPPPPLPHPPPPLPPPPQQPHPPLP 483
H ++ L H Q P Q P + P P P QP LP
Sbjct: 3907 SHFEQQTLYHQQVSPYQTQPTFQAVATMSFTPQVQPTPTPQPSYQLP 3953
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 74.3 bits (181), Expect = 6e-13
Identities = 142/619 (22%), Positives = 222/619 (35%), Gaps = 127/619 (20%)
Query: 265 ITTEGGQMSRADAPAYGG-LQGSSPFYQSHQSPVAQQEALSHPSHKFQSPAVCSSSVCCS 323
I+++ + ++ P G +QG + Q+ + + Q S P K Q+ V SV S
Sbjct: 239 ISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTK-QADIVRGESVKPS 297
Query: 324 HCSPVSPSLKGQVP--PPSIHPAHSFRQPPEMVPQQLGSLQCSALLPREKELACSPHPPK 381
SP P ++ P PP+ P H QP P S L + + PP
Sbjct: 298 LPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPG 357
Query: 382 LLQPWLE----TQPPVEQ----ESTSQRLGQQLTSQPVCI--VPPQD-------VQQGAH 424
+P + +PP +Q + +S++ G + +QP + P Q QQ
Sbjct: 358 TTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGT 417
Query: 425 AQPTLQTPSIQV-----------------------QFGHHQKLKLSHFQQQPQQQLPPPP 461
+P Q P +Q Q G + +P QLP P
Sbjct: 418 PKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPA 477
Query: 462 PPLPHPPPPLPPPPQQPHPPLPPSQHLASSQ-HESPPGPACSQNMDIMHHKFELEEMQKD 520
P P P P PPPQQP PPSQ S++ PGPA
Sbjct: 478 KPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPA-------------------- 517
Query: 521 LELLLQAQQPSLQLSQTKSPQHLQQTIVGQINYIVRQPAPVQSQSQEETLQATDEPPASQ 580
+PS Q + P Q G +QP+P + +Q+ T +P +
Sbjct: 518 --------KPSPQQPGSTKPPSQQP---GSAKPSAQQPSPAKPSAQQST-----KPVSQT 561
Query: 581 GS-KPALPLDKNTAAALPQASGEETPLSVPPVDSTI-------QHSSPNVVRKHSTSL-S 631
GS KP P + +A P + G P ++ P+ +T + ++ N + T++ S
Sbjct: 562 GSGKPLQPPTVSPSAKQPPSQG--LPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCS 619
Query: 632 IMGF------SNTLEMELSSTRLERPLEPQIQSVSNLTAGAPQAVPSLLSAPPKMVSSL- 684
+ GF + E + +++R L + V + +PQ P L +AP S++
Sbjct: 620 LCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPS----SPQ--PKLKTAPVTTTSAVS 673
Query: 685 --------TSVQNQAMPSLTTSHL----QTVPSLVHSTFQSMPNLISDSPQAMASLASDH 732
TS + A P S + P + T P+ + P SL+
Sbjct: 674 KSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPA 733
Query: 733 PQAGPSLMSGHTQAVPSLATCPLQSIPPVSDMQPETGSSSSSGRTSGSLCPRDGADPSLE 792
P PS+ S +A P P Q ++P T SSS T+ P E
Sbjct: 734 PPKEPSVPSEQDKA-PVADDKPKQP----KMVKPTTDLVSSSSATTKPDIPSSKVQSQAE 788
Query: 793 NALCKVKLEEPINLSVKKP 811
K P+ KP
Sbjct: 789 E-----KTTPPLKTDSAKP 802
Score = 55.1 bits (131), Expect = 4e-07
Identities = 158/696 (22%), Positives = 228/696 (32%), Gaps = 131/696 (18%)
Query: 333 KGQVPPPSIHPAHSFRQPPEMVPQQLGSLQCSALLPREKELACSPHPPKLLQPWLETQPP 392
K Q P I +QPP+ +P+Q G + + S P K+ T P
Sbjct: 198 KEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIKSQPPGTGKP 257
Query: 393 VEQESTSQRLG------QQLTSQPVCIVPPQDVQQGAHAQPTLQTPS----IQVQFGHHQ 442
++ + + + Q+ S+P D+ +G +P+L +PS Q G
Sbjct: 258 IQGPTQTPQTDHAKLPLQRDASRPQ--TKQADIVRGESVKPSLPSPSKPPIQQPTPGKPP 315
Query: 443 KLKLSHFQQQPQQQLPPPPP-----PLPHPP----PPLPP-----PPQQP-HPPLPPSQH 487
+ H + QP PP P PL P PP+ P PP QP P PP+Q
Sbjct: 316 AQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQ 375
Query: 488 LASSQHES----------PPGPACSQNMDIMHHKFELEEMQKDLELLLQAQQPSLQLSQT 537
S + S PPG + K +++ L AQQP LQ S
Sbjct: 376 TGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPL---AQQPGLQ-SPA 431
Query: 538 KSPQHLQQTIVGQINYIVRQPAPVQSQSQE------ETLQATDEPPASQGSKPALPLDKN 591
K+P G V+QP P + +Q+ Q P SQ PA P +
Sbjct: 432 KAP--------GPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQ 483
Query: 592 TAAAL--PQASGEETPLSVPPVDSTIQHSSPNVVRKHSTSL-SIMGFSNTLEMELSSTRL 648
A PQ G P S P + P + S S S +
Sbjct: 484 PGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQ 543
Query: 649 ERPLEPQIQS----VSNLTAGAPQAVPSLLSAPPKMVSSLTSVQNQAMPSLTTSHLQTVP 704
P +P Q VS +G P PP + S +Q +P T
Sbjct: 544 PSPAKPSAQQSTKPVSQTGSGKP-------LQPPTVSPSAKQPPSQGLPKTICPLCNTTE 596
Query: 705 SLVHSTFQSMPNLISDSPQAMASLASDHPQ-------------------AGPSLMSGHTQ 745
L+H ++ N ++ + SL +P G L +
Sbjct: 597 LLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSS 656
Query: 746 AVPSLATCPLQSIPPVSDMQPETGSSSSSGRTSGSLCPRDGADPSLENALCKVKLEEPIN 805
P L T P+ + VS P+ +S P+ A P + + K EP
Sbjct: 657 PQPKLKTAPVTTTSAVSKSSPQPQQTS----------PKKDAAPKQDLS----KAPEP-- 700
Query: 806 LSVKKPPLAPVVSTSTALQQYQNPKECENFEQGALELDAKENQSIRAFNSEHKIPYVRLE 865
KKPP P+V T L + K + E +L A K P V E
Sbjct: 701 ---KKPP--PLVKQPT-LHGSPSAKAKQPPEADSLSKPAPP-----------KEPSVPSE 743
Query: 866 RLKICAASSGEMPVFKLKPQKNDQDGSFLLIIECGTESSSMSIKVSQDRLSEATQAPGLE 925
+ K A K K K + + L+ T + Q + E T P
Sbjct: 744 QDKAPVADD------KPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPP--- 794
Query: 926 GRKVTVTSLAGQRPPEVEGTSPEEHRLIPRTPGAKK 961
K + PP E SP + + IPR K
Sbjct: 795 -LKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSK 829
Score = 55.1 bits (131), Expect = 4e-07
Identities = 91/380 (23%), Positives = 135/380 (35%), Gaps = 42/380 (11%)
Query: 378 HPPKLLQPWLETQPPVEQESTSQRLGQQLTSQPVCIVPPQDVQQGAHAQPTLQTPSIQVQ 437
HPP + P EQ ST+ + Q P + G+ + +L P+
Sbjct: 2342 HPPSSVI----ALPMKEQLSTTYFTSGETFGQEK---PASQLPSGSPSVSSL--PAKPRP 2392
Query: 438 FGHHQKLKLSHFQQQPQQQLPPPPPPLPHPPPPLPPPPQQPHPPLPPSQHLASSQHESPP 497
F L +S P PPPPPP P PPPP PPP P P + P + L + +
Sbjct: 2393 FFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKLTVASPVTTA 2452
Query: 498 GPACSQNMDIMHHKFELEEMQKDLELLLQAQQPSLQLSQTKSPQHLQQTIVGQINYIVRQ 557
P + + L + + P + + P L T + +
Sbjct: 2453 TPLFDA-VTTLETTAVLRSNGLPVTRICTTAPPPVPPKPSSIPSGLVFTHRPEPSKPPIA 2511
Query: 558 PAPVQSQSQEETLQATDEPPASQGSKPALPLDKNTAAALPQASGEETPLSVPPVDSTIQH 617
P PV Q T + TD P G L L + L ++ + P P+
Sbjct: 2512 PKPVIPQLPTTTQKPTDIHPKPTG----LSLTSSMTLNLVTSADYKLPSPTSPLSPHSNK 2567
Query: 618 SSPNVVRKHSTSLSIMGFSNTLEMELSSTRLERPLEPQIQSVSNLTAGAPQAVPS--LLS 675
SSP + S SL+ E + T P P S S P PS L+S
Sbjct: 2568 SSP----RFSKSLT--------ETYVVITLPSEPGTPTDSSASQAITSWPLGSPSKDLVS 2615
Query: 676 APP--KMVSSLTSVQNQAMPSLT---TSHLQT---VPSLVHSTFQSMPNLISD------S 721
P +V +T+V+ T + LQT P S+FQ+ P ++ S
Sbjct: 2616 VEPVFSVVPPVTAVEIPISSEQTFYISGALQTFSATPVTAPSSFQAAPTSVTQFLTTEVS 2675
Query: 722 PQAMASLASDHPQAGPSLMS 741
+++ S P G S +S
Sbjct: 2676 KTEVSATRSTAPSVGLSSIS 2695
Score = 37.4 bits (85), Expect = 0.088
Identities = 101/566 (17%), Positives = 188/566 (33%), Gaps = 92/566 (16%)
Query: 326 SPVSPSLKGQVPPPSIHPAHSFRQPPEMVPQQLGSLQCSALLPREKELACSPHPPKLLQP 385
+P+ + PP S P S Q P + + + + EK + P + +
Sbjct: 962 APMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRT 1021
Query: 386 WLETQPPVEQESTSQRLGQQLTSQPVCIVPPQDVQQGAHAQPTLQTPSIQVQFGH----- 440
E +PP ++S S LT++P V P +++ + T ++ G
Sbjct: 1022 ETEKKPPPIKDSKS------LTAEPQKAVLPTKLEKSPKPESTCPLCKTELNIGSKDPPN 1075
Query: 441 --------HQKLKLSHFQQQPQ-------------------------QQLPPPPPPLPHP 467
+Q L F P +++PP P
Sbjct: 1076 FNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIRKMPPAPSGPKAS 1135
Query: 468 PPPLPPPPQQPHPPLPPSQHLASSQHESPPGPACSQNMDIMHHKFELEEMQKDLELLLQA 527
P P+P +PP L Q Q + K LE++++ L ++
Sbjct: 1136 PMPVPTESSSQKTAVPPQVKLVKKQ---------EQEVKTEAEKVILEKVKETLS--MEK 1184
Query: 528 QQPSLQLSQTKSPQHLQQTIVGQINYIVRQPAPVQSQ--SQEETLQATDEPPASQGSKPA 585
P + Q + L++ + ++P P + + +EE +++ ++ P + KP
Sbjct: 1185 IPPMVTTDQKQEESKLEKDKASALQ--EKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPT 1242
Query: 586 LPLDKNTAAALPQASGEETPLSVPPVDSTIQHSSPNVVRKHSTSLSIMGFSNTLEMELSS 645
P DK LP+A + S+P + + LE ++
Sbjct: 1243 -PEDKK---LLPEA----------------KTSAPEEQKHDLLKSQVQIAEEKLEGRVAP 1282
Query: 646 TRLERPLEPQIQSVSNLTAGAPQAVPSLLSAPPKMVSSLTSVQNQAMPSLTTSHLQTVPS 705
++ +PQ + + L +G PQ++P K +++ Q P T Q P
Sbjct: 1283 KTVQEGKQPQTK-MEGLPSGTPQSLPKEDDKTTK------TIKEQPQPPCTAKPDQVEPG 1335
Query: 706 LVHSTFQSMPNLISDSPQAMASLASDHPQAGPSLMSGHTQAVPSLATCPLQSIPPVSDMQ 765
+ + + S S Q + +S +PSL P + ++
Sbjct: 1336 KEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSL--IPTDEKDILKGLK 1393
Query: 766 PETGSSSSSGRTSGSLCPRDGADPSLENALCKVKLEEPINLSVKKPPLAPVVSTSTALQQ 825
++ S SS + L + S+ A +E +K VS Q
Sbjct: 1394 KDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADE----KSEKKTQPHEVSPEQPKDQ 1449
Query: 826 YQNPKECENFEQGALELDAKENQSIR 851
+ E E E + KE+Q R
Sbjct: 1450 EKTQSLSETLEITISEEEIKESQEER 1475
Score = 35.4 bits (80), Expect = 0.33
Identities = 47/243 (19%), Positives = 91/243 (37%), Gaps = 32/243 (13%)
Query: 458 PPPPPPLP----------HPPPPLPPP--PQQPHPPLPPSQHLASSQHESPPGPACSQNM 505
PPP PP P H P P PP P+ P LP + + H P G + + +M
Sbjct: 2483 PPPVPPKPSSIPSGLVFTHRPEPSKPPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLTSSM 2542
Query: 506 DIMHHKFELEEMQKDLELLLQAQQPSLQLSQTKSPQHLQQTIVGQINYIVRQPAPVQSQS 565
+ + + L + L KS +++ + ++ P+ + +
Sbjct: 2543 TL--------NLVTSADYKLPSPTSPLSPHSNKSSPRFSKSLT-ETYVVITLPSEPGTPT 2593
Query: 566 QEETLQATDEPPASQGSKPALPLDKNTAAALPQASGEETPLSVPP---VDSTIQH----- 617
QA P SK + ++ + +P + E P+S + +Q
Sbjct: 2594 DSSASQAITSWPLGSPSKDLVSVEP-VFSVVPPVTAVEIPISSEQTFYISGALQTFSATP 2652
Query: 618 -SSPNVVRKHSTSLSIMGFSNTLEMELSSTRLERPLEPQIQSVSNLTAGAPQAVPSLLSA 676
++P+ + TS++ + + E+S+TR P + S+S P A+ ++
Sbjct: 2653 VTAPSSFQAAPTSVTQFLTTEVSKTEVSATRSTAP-SVGLSSISITIPPEPLALDNIHLE 2711
Query: 677 PPK 679
P+
Sbjct: 2712 KPQ 2714
Score = 33.1 bits (74), Expect = 1.7
Identities = 80/378 (21%), Positives = 130/378 (34%), Gaps = 74/378 (19%)
Query: 286 SSPFYQSHQSPVAQQEALSHPSHKFQSPAVCSSSVCCSHCSPVSPSLKGQVPPPSIH--- 342
SSP + +PV A+S S + P S + +S + + + PPP +
Sbjct: 655 SSPQPKLKTAPVTTTSAVSKSSPQ---PQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPT 711
Query: 343 ----PAHSFRQPPEMVPQQLGSLQCSALLPREKELAC----SPHPPKLLQPWLE------ 388
P+ +QPPE + +P E++ A P PK+++P +
Sbjct: 712 LHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSS 771
Query: 389 -------------------TQPPVEQESTSQRLGQQLTSQPVCIV-------PPQDVQQG 422
T PP++ +S T + V P D +
Sbjct: 772 ATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKII 831
Query: 423 AHAQPTLQTPSIQVQFGHHQKL---KLSHFQQQPQQQLPPPPPPLPHPPPPLP------P 473
+H P+ ++ Q Q QK K + + P+ P P P PP P P P
Sbjct: 832 SHPGPSSESKG-QKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVP 890
Query: 474 PPQQPHPPLPPSQHLA---SSQHESPPGPACSQNMDIMHHKFEL--EEMQKDLELLLQAQ 528
PQQ P S+ + S ++P + + F + L+ A
Sbjct: 891 TPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAG 950
Query: 529 QPSLQLSQTKSPQHLQQTIVGQINYIVRQPAPVQSQSQEETLQATDE-PPASQGSKPALP 587
QP SQ+ ++Q PAP Q + + ++T + PPA S P
Sbjct: 951 QPGPH-SQSGPGAPMKQA-----------PAPSQPPTSQGPPKSTGQAPPAPAKSIPVKK 998
Query: 588 LDKNTAAALPQASGEETP 605
K AA + E+ P
Sbjct: 999 ETKAPAAEKLEPKAEQAP 1016
Score = 33.1 bits (74), Expect = 1.7
Identities = 30/108 (27%), Positives = 45/108 (41%), Gaps = 7/108 (6%)
Query: 355 PQQLGSLQCSALLPREKELACSPHPPKLLQPWLETQPPVEQESTSQRLGQQLTSQPVCIV 414
P G SA +P EK L P K+L P + PP ++ ++ Q+ S P +
Sbjct: 3629 PLSPGKALESAFVPYEKPLPDDISPQKVLHPDMAKVPPASPKTA--KMMQRSMSDPKPLS 3686
Query: 415 PPQDVQQGAHAQPTLQTPSIQVQFGHHQKLKLSHFQQQPQQQLPPPPP 462
P D A Q T + Q + S Q++ ++ LP PPP
Sbjct: 3687 PTADESSRAPFQYTEGYTT-----KGSQTMTSSGAQKKVKRTLPNPPP 3729
Score = 32.3 bits (72), Expect = 2.8
Identities = 28/107 (26%), Positives = 42/107 (39%), Gaps = 10/107 (9%)
Query: 387 LETQPPVEQEST------SQRLGQQLTSQPVCIVPPQDVQQGAHAQPTL--QTPSIQVQF 438
+E+Q +E+ T SQ + Q ++ + P Q ++ P L Q P+ Q
Sbjct: 3847 IESQHGIERPRTAPQTEFSQFIPPQTQTESQLVPPTSPYTQYQYSSPALPTQAPTSYTQQ 3906
Query: 439 GHHQKLKLSHFQQQPQQQLP--PPPPPLPHPPPPLPPPPQQPHPPLP 483
H ++ L H Q P Q P + P P P QP LP
Sbjct: 3907 SHFEQQTLYHQQVSPYQTQPTFQAVATMSFTPQVQPTPTPQPSYQLP 3953
>gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens]
Length = 748
Score = 73.2 bits (178), Expect = 1e-12
Identities = 86/295 (29%), Positives = 122/295 (41%), Gaps = 23/295 (7%)
Query: 331 SLKGQVPPPSIHPA-HSFRQPPEMVPQQLGSLQCSALLPREKELACSPHPPKLLQPWLET 389
SL GQ PP + A HS PQ LQ AL ++++ LQ +
Sbjct: 124 SLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQ 183
Query: 390 QPPVE---QESTSQRLGQQLTSQPVCIVPPQDVQQGA---HAQPTLQTPSIQVQFGHHQK 443
Q + Q+S Q+ Q + Q + Q QQ H Q Q Q Q +
Sbjct: 184 QQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQ 243
Query: 444 LKLSHFQQQPQQQLPPPPPPLPHPPPPLPPPPQQPHPP----LPPS-QHLASSQHESPPG 498
L+L QQQ QQQ L PP PP QQP PP LP Q + +QH PP
Sbjct: 244 LQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPP- 302
Query: 499 PACSQNMDIMHHKFELEEMQKDLELLLQAQQPSLQLSQTKSPQHLQQTIVGQINYIVRQP 558
P Q + +L + L+ QAQ Q+ T+ P + + +V+QP
Sbjct: 303 PQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPM-----VVQQP 357
Query: 559 APVQSQSQEETLQATDEPPASQGSKPALPLDKNTAAALPQAS-GE--ETPLSVPP 610
PVQ Q Q++ A A+Q P + + +++ L S G+ +TP S+PP
Sbjct: 358 -PVQPQVQQQQ-TAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPP 410
Score = 51.2 bits (121), Expect = 6e-06
Identities = 58/194 (29%), Positives = 73/194 (37%), Gaps = 27/194 (13%)
Query: 335 QVPPPSIHPAHSFRQPP--EMVPQQLGSL---QCSALLPREKELACSPHPPKLLQPWLET 389
Q PP P QPP + +PQQL + Q P+ ++ + + P L P +T
Sbjct: 265 QAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQT 324
Query: 390 QPPVEQESTSQRLGQQLTSQP---------VCIVPP--QDVQQGAHAQPTLQT-----PS 433
QP V Q GQ L +QP V PP VQQ A T Q P
Sbjct: 325 QPLVSQAQALP--GQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPG 382
Query: 434 IQVQFGHHQKLKLSHFQQQPQ--QQLPPPPPPLPHPPPPLPPPPQ--QPHPPLPPSQHLA 489
+QV L QQ Q Q +PPPP P P P P P P PS L
Sbjct: 383 VQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLP 442
Query: 490 SSQHESPPGPACSQ 503
S + P ++
Sbjct: 443 SPSPQPSQSPVTAR 456
Score = 45.1 bits (105), Expect = 4e-04
Identities = 84/403 (20%), Positives = 141/403 (34%), Gaps = 69/403 (17%)
Query: 426 QPTLQTPSIQVQFGHHQKLKLSHFQQQPQQQLPPPPPPLPHPPPPLPPPPQQPHPPLPPS 485
Q LQ Q QF Q+ L QQQ QQQ QQ +
Sbjct: 157 QVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQAQQSAMQ---------QQFQAVVQQQ 207
Query: 486 QHLASSQHESPPGPACSQNMDIMHHKFE--LEEMQKDLELLLQAQQPSLQLSQTKSPQHL 543
Q L Q + Q++ +HH+ + +++ Q+ L+ + Q Q Q Q + Q
Sbjct: 208 QQLQQQQQQQ-------QHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQQQQQQQ 260
Query: 544 QQTIVGQINYIVRQPAPVQSQSQEETLQATDEPPASQGSKPALPLDKNTAAALPQASGEE 603
QQ + Q P+Q ++ +PP SQ L +T P ++
Sbjct: 261 QQALQAQ--------PPIQQPPMQQP-----QPPPSQALPQQLQQMHHTQHHQPPPQPQQ 307
Query: 604 TPLSVPPVDSTIQHSSPNVVRKHSTSLSIMGFSNTLEMELSSTRLERPLEPQIQSVSNLT 663
P++ + P+ + S + ++ + L ++ T +P ++ V
Sbjct: 308 PPVA---------QNQPSQLPPQSQTQPLVSQAQALPGQMLYT------QPPLKFVR--- 349
Query: 664 AGAPQAVPSLLSAPPKMVSSLTSVQNQAMPSLTTSHLQTVPSLVHSTFQSMPNLISDSPQ 723
AP V P++ T+VQ + +Q S + P +PQ
Sbjct: 350 --APMVVQQP-PVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQ 406
Query: 724 AMASLASDHPQAGPSLMSGHTQAVPSLATCPLQSIPPVSDMQPETGSSSSSGRTSGSLCP 783
+M PQ G ++ A P +P S P+ S + RT P
Sbjct: 407 SMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPS---PQPSQSPVTART-----P 458
Query: 784 RDGADPSLENALCKVKLEEPINLSVKKPPLAPVVSTSTALQQY 826
++ + PS L P+N S ++P S+ QQY
Sbjct: 459 QNFSVPS------PGPLNTPVNPS---SVMSPAGSSQAEEQQY 492
>gi|94681063 bromodomain adjacent to zinc finger domain, 2B [Homo
sapiens]
Length = 2168
Score = 72.4 bits (176), Expect = 2e-12
Identities = 61/229 (26%), Positives = 86/229 (37%), Gaps = 62/229 (27%)
Query: 972 FCAVCLNGGE---LLCCDRCPKVFHLSCHVPALLSFPGGEWVCTLC-------------- 1014
+C +C G LL CD C K H CH P + + P G+W C C
Sbjct: 1933 YCQICRKGDNEELLLLCDGCDKGCHTYCHRPKITTIPDGDWFCPACIAKASGQTLKIKKL 1992
Query: 1015 -------------RSLTQPEMEYDCENACYNQPGMRASPGL------------------- 1042
+ +T D ++A + R + L
Sbjct: 1993 HVKGKKTNESKKGKKVTLTGDTEDEDSASTSSSLKRGNKDLKKRKMEENTSINLSKQESF 2052
Query: 1043 -SMYDQKKCEKLVLSLCCNNLS-LPFHEPVSP--------LARHYYQIIKRPMDLSIIRR 1092
S+ K+ + L+LC L+ + HE P L Y ++IK+PMD S IR
Sbjct: 2053 TSVKKPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKVIKKPMDFSTIRE 2112
Query: 1093 KLQKKDPAHYTTPEEVVSDVRLMFWNCAKFNYPDSEVAEAGRCLEVFFE 1141
KL Y E DVRL+F NC FN DS++ AG + +FE
Sbjct: 2113 KLSS---GQYPNLETFALDVRLVFDNCETFNEDDSDIGRAGHNMRKYFE 2158
>gi|51477700 mediator complex subunit 15 isoform a [Homo sapiens]
Length = 788
Score = 71.6 bits (174), Expect = 4e-12
Identities = 109/411 (26%), Positives = 155/411 (37%), Gaps = 46/411 (11%)
Query: 331 SLKGQVPPPSIHPA-HSFRQPPEMVPQQLGSLQCSALLPREKELACSPHPPKLLQPWLET 389
SL GQ PP + A HS PQ LQ AL ++++ LQ +
Sbjct: 124 SLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQ 183
Query: 390 QPPVE---QESTSQRLGQQLTSQPVCIVPPQDVQQGA---HAQPTLQTPSIQVQFGHHQK 443
Q + Q+S Q+ Q + Q + Q QQ H Q Q Q Q +
Sbjct: 184 QQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQ 243
Query: 444 LKLSHFQQQPQQQLPPPPPPLPHPPPPLPPPPQQPHPP----LPPS-QHLASSQHESPPG 498
L+L QQQ QQQ L PP PP QQP PP LP Q + +QH PP
Sbjct: 244 LQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPP- 302
Query: 499 PACSQNMDIMHHKFELEEMQKDLELLLQAQQPSLQLSQTKSPQHLQQTIVGQINYIVRQP 558
P Q + +L + L+ QAQ Q+ T+ P + + +V+QP
Sbjct: 303 PQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPM-----VVQQP 357
Query: 559 APVQSQSQEET---------------LQATDEPPASQGSKPALPLDKNTA-AALPQASGE 602
PVQ Q Q++ +Q E A G TA +A+P +S
Sbjct: 358 -PVQPQVQQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHIRARFPPTTAVSAIPSSS-- 414
Query: 603 ETPLSVPPVDSTIQHSSPNVVRKHSTSLSIMGFSNTLEMELSSTRLERPLEPQIQSVSNL 662
PL P+ Q S P + S+ M +P +P Q SN+
Sbjct: 415 -IPLGRQPMAQVSQSSLPML----SSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNV 469
Query: 663 TAGAPQAVPSLLSAPPKMVS----SLTSVQNQAMPSLTTSHLQTVPSLVHS 709
++G + S L +P S + + QN ++PS + PS V S
Sbjct: 470 SSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMS 520
>gi|190343010 SP110 nuclear body protein isoform a [Homo sapiens]
Length = 689
Score = 71.2 bits (173), Expect = 5e-12
Identities = 60/210 (28%), Positives = 85/210 (40%), Gaps = 43/210 (20%)
Query: 941 EVEGTSPEEHRLIPRTPGAKKGPPAPIENEDFCAVCLNGGELLCCDRCPKVFHLSCHVPA 1000
E +G + + + R G G +N D C VC GG+LLCC CP+VFH CH+P
Sbjct: 505 EGKGRNAKNWKRNIRCEGMTLGELLKRKNSDECEVCCQGGQLLCCGTCPRVFHEDCHIPP 564
Query: 1001 LLSFPGGEWVCTLCRSLTQPEMEYDCENACYNQPGMRASPGLSMYDQKKCEKLVLSLCCN 1060
+ W CT CR M+ S G S C+
Sbjct: 565 -VEAKRMLWSCTFCR--------------------MKRSSG--------------SQQCH 589
Query: 1061 NLSLPFHEPVSP---LARHYYQIIKRPMDLSIIRRKLQKKDPAHYTTPEEVVSDVRLMFW 1117
++S + P L R Y + + M L +++ +L T V D+RLMF
Sbjct: 590 HVSKTLERQMQPQDQLIRDYGEPFQEAMWLDLVKERL----ITEMYTVAWFVRDMRLMFR 645
Query: 1118 NCAKFNYPDSEVAEAGRCLEVFFEGWLKEI 1147
N F Y S+ + G LE FE LK++
Sbjct: 646 NHKTF-YKASDFGQVGLDLEAEFEKDLKDV 674
Score = 32.3 bits (72), Expect = 2.8
Identities = 35/143 (24%), Positives = 55/143 (38%), Gaps = 18/143 (12%)
Query: 457 LPPPPPPLPHPPPPLPPPPQQPHPPLPPSQHLASSQHESPP----------GPACSQNMD 506
LPPP PP P P P + + L+ S S P G + S D
Sbjct: 139 LPPPQPPQPSCSPCAPRVSEPGTSSQQSDEILSESPSPSDPVLPLPALIQEGRSTSVTND 198
Query: 507 IMHHKFELEEMQKDLELLL----QAQQPSL--QLSQTKSPQHLQQTIVGQINYIVRQPAP 560
+ K EE +++ LL Q +L Q+ + PQ + + +G + I R +P
Sbjct: 199 KLTSKMNAEEDSEEMPSLLTSTVQVASDNLIPQIRDKEDPQEMPHSPLGSMPEI-RDNSP 257
Query: 561 VQSQSQEETLQATDEPPASQGSK 583
+ EE + + P +G K
Sbjct: 258 -EPNDPEEPQEVSSTPSDKKGKK 279
>gi|164419758 bromodomain containing 2 [Homo sapiens]
Length = 801
Score = 70.5 bits (171), Expect = 9e-12
Identities = 48/122 (39%), Positives = 64/122 (52%), Gaps = 19/122 (15%)
Query: 1065 PFHEPV--SPLARH-YYQIIKRPMDLSIIRRKLQKKDPAHYTTPEEVVSDVRLMFWNCAK 1121
PF++PV S L H Y+ IIK PMDLS ++RK++ +D Y +E +DVRLMF NC K
Sbjct: 371 PFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRD---YRDAQEFAADVRLMFSNCYK 427
Query: 1122 FNYPDSEVAEAGRCLEVFFEGWLKEIYPEKRFAQP-------------RQEDSDSEEVSS 1168
+N PD +V R L+ FE ++ E P +S SEE SS
Sbjct: 428 YNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSESSSEESSS 487
Query: 1169 ES 1170
ES
Sbjct: 488 ES 489
Score = 50.4 bits (119), Expect = 1e-05
Identities = 31/105 (29%), Positives = 52/105 (49%), Gaps = 7/105 (6%)
Query: 1040 PGLSMYDQKKCEKLVL-SLCCNNLSLPFHEPVSPLAR---HYYQIIKRPMDLSIIRRKLQ 1095
PG + K+V+ +L + + PF +PV + Y++IIK+PMD+ I+R+L+
Sbjct: 72 PGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLE 131
Query: 1096 KKDPAHYTTPEEVVSDVRLMFWNCAKFNYPDSEVAEAGRCLEVFF 1140
+Y E + D MF NC +N P ++ + LE F
Sbjct: 132 NN---YYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIF 173
>gi|4826806 bromodomain containing 2 [Homo sapiens]
Length = 801
Score = 70.5 bits (171), Expect = 9e-12
Identities = 48/122 (39%), Positives = 64/122 (52%), Gaps = 19/122 (15%)
Query: 1065 PFHEPV--SPLARH-YYQIIKRPMDLSIIRRKLQKKDPAHYTTPEEVVSDVRLMFWNCAK 1121
PF++PV S L H Y+ IIK PMDLS ++RK++ +D Y +E +DVRLMF NC K
Sbjct: 371 PFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRD---YRDAQEFAADVRLMFSNCYK 427
Query: 1122 FNYPDSEVAEAGRCLEVFFEGWLKEIYPEKRFAQP-------------RQEDSDSEEVSS 1168
+N PD +V R L+ FE ++ E P +S SEE SS
Sbjct: 428 YNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSESSSEESSS 487
Query: 1169 ES 1170
ES
Sbjct: 488 ES 489
Score = 50.4 bits (119), Expect = 1e-05
Identities = 31/105 (29%), Positives = 52/105 (49%), Gaps = 7/105 (6%)
Query: 1040 PGLSMYDQKKCEKLVL-SLCCNNLSLPFHEPVSPLAR---HYYQIIKRPMDLSIIRRKLQ 1095
PG + K+V+ +L + + PF +PV + Y++IIK+PMD+ I+R+L+
Sbjct: 72 PGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLE 131
Query: 1096 KKDPAHYTTPEEVVSDVRLMFWNCAKFNYPDSEVAEAGRCLEVFF 1140
+Y E + D MF NC +N P ++ + LE F
Sbjct: 132 NN---YYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIF 173
>gi|34335264 zinc finger, MYND-type containing 8 isoform c [Homo
sapiens]
Length = 1135
Score = 70.5 bits (171), Expect = 9e-12
Identities = 68/259 (26%), Positives = 107/259 (41%), Gaps = 44/259 (16%)
Query: 939 PPEVEGTSPEEHRLIPRTPGAKKGPPAPIE---------NEDFCAVCLNGGELLCCDRCP 989
P G SP++ +P KK P + N+ +C VC G++LCC+ CP
Sbjct: 46 PHSSNGHSPQD---TSTSPIKKKKKPGLLNSNNKEQDGRNDFYCWVCHREGQVLCCELCP 102
Query: 990 KVFHLSCHVPALLSFPGGEWVCTLCRSLTQPEMEYDCENACYNQPGMRASPGLSMYDQKK 1049
+V+H C L S P G+W C C +T E C S ++M ++
Sbjct: 103 RVYHAKC--LRLTSEPEGDWFCPECEKITVAE--------CIE----TQSKAMTMLTIEQ 148
Query: 1050 CEKLVLSLCCNNLSLP----FHEPVSPLARH--YYQIIKRPMDLSIIRRKLQKKDPAHYT 1103
L L + P F +PV PL +H Y + I PMDL + + +KK Y
Sbjct: 149 LSYL-LKFAIQKMKQPGTDAFQKPV-PLEQHPDYAEYIFHPMDLCTLEKNAKKK---MYG 203
Query: 1104 TPEEVVSDVRLMFWNCAKFNYPDSEVAEAGRCLEVFFEGWLKEI--YPEKRFAQPRQEDS 1161
E ++D + + NC +N + ++ + + + E + EI PE A ++ D+
Sbjct: 204 CTEAFLADAKWILHNCIIYNGGNHKLTQIAKVVIKICEHEMNEIEVCPECYLAACQKRDN 263
Query: 1162 DSEEVSSESGCSTPQGFPW 1180
E CS P W
Sbjct: 264 WFCE-----PCSNPHPLVW 277
>gi|34335262 zinc finger, MYND-type containing 8 isoform a [Homo
sapiens]
Length = 1188
Score = 70.5 bits (171), Expect = 9e-12
Identities = 61/225 (27%), Positives = 96/225 (42%), Gaps = 32/225 (14%)
Query: 964 PAPIENEDFCAVCLNGGELLCCDRCPKVFHLSCHVPALLSFPGGEWVCTLCRSLTQPEME 1023
P N+ +C VC G++LCC+ CP+V+H C L S P G+W C C +T E
Sbjct: 102 PQDGRNDFYCWVCHREGQVLCCELCPRVYHAKC--LRLTSEPEGDWFCPECEKITVAE-- 157
Query: 1024 YDCENACYNQPGMRASPGLSMYDQKKCEKLVLSLCCNNLSLP----FHEPVSPLARH--Y 1077
C S ++M ++ L L + P F +PV PL +H Y
Sbjct: 158 ------CIE----TQSKAMTMLTIEQLSYL-LKFAIQKMKQPGTDAFQKPV-PLEQHPDY 205
Query: 1078 YQIIKRPMDLSIIRRKLQKKDPAHYTTPEEVVSDVRLMFWNCAKFNYPDSEVAEAGRCLE 1137
+ I PMDL + + +KK Y E ++D + + NC +N + ++ + + +
Sbjct: 206 AEYIFHPMDLCTLEKNAKKK---MYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKVVI 262
Query: 1138 VFFEGWLKEI--YPEKRFAQPRQEDSDSEEVSSESGCSTPQGFPW 1180
E + EI PE A ++ D+ E CS P W
Sbjct: 263 KICEHEMNEIEVCPECYLAACQKRDNWFCE-----PCSNPHPLVW 302
>gi|34335266 zinc finger, MYND-type containing 8 isoform b [Homo
sapiens]
Length = 1160
Score = 70.5 bits (171), Expect = 9e-12
Identities = 61/225 (27%), Positives = 96/225 (42%), Gaps = 32/225 (14%)
Query: 964 PAPIENEDFCAVCLNGGELLCCDRCPKVFHLSCHVPALLSFPGGEWVCTLCRSLTQPEME 1023
P N+ +C VC G++LCC+ CP+V+H C L S P G+W C C +T E
Sbjct: 102 PQDGRNDFYCWVCHREGQVLCCELCPRVYHAKC--LRLTSEPEGDWFCPECEKITVAE-- 157
Query: 1024 YDCENACYNQPGMRASPGLSMYDQKKCEKLVLSLCCNNLSLP----FHEPVSPLARH--Y 1077
C S ++M ++ L L + P F +PV PL +H Y
Sbjct: 158 ------CIE----TQSKAMTMLTIEQLSYL-LKFAIQKMKQPGTDAFQKPV-PLEQHPDY 205
Query: 1078 YQIIKRPMDLSIIRRKLQKKDPAHYTTPEEVVSDVRLMFWNCAKFNYPDSEVAEAGRCLE 1137
+ I PMDL + + +KK Y E ++D + + NC +N + ++ + + +
Sbjct: 206 AEYIFHPMDLCTLEKNAKKK---MYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKVVI 262
Query: 1138 VFFEGWLKEI--YPEKRFAQPRQEDSDSEEVSSESGCSTPQGFPW 1180
E + EI PE A ++ D+ E CS P W
Sbjct: 263 KICEHEMNEIEVCPECYLAACQKRDNWFCE-----PCSNPHPLVW 302
>gi|194248081 tripartite motif-containing 2 isoform 2 [Homo sapiens]
Length = 744
Score = 67.8 bits (164), Expect = 6e-11
Identities = 48/219 (21%), Positives = 91/219 (41%)
Query: 63 LYCPLHTQEVLKLFCETCDMLTCHSCLVVEHKEHRCRHVEEVLQNQRMLLEGVTTQVAHK 122
L CP H V++ +C++C+ C C EH EH +++V++ + L+ V +
Sbjct: 116 LSCPNHDGNVMEFYCQSCETAMCRECTEGEHAEHPTVPLKDVVEQHKASLQVQLDAVNKR 175
Query: 123 KSSLQTSAKQIEDRIFEVKHQHRKVENQIKMAKMVLMNELNKQANGLIEELEGITNERKR 182
+ ++ + I + I ++ +Q + + I L LN + + L+ ELE + +
Sbjct: 176 LPEIDSALQFISEIIHQLTNQKASIVDDIHSTFDELQKTLNVRKSVLLMELEVNYGLKHK 235
Query: 183 KLEQQLQSIMVLNRQFEHVQNFINWAVCSKTSVPFLFSKELIVFQMQRLLETSCNTDPGS 242
L+ QL +++ + NF A+ T L K+ + ++ L + P
Sbjct: 236 VLQSQLDTLLQGQESIKSCSNFTAQALNHGTETEVLLVKKQMSEKLNELADQDFPLHPRE 295
Query: 243 PWSIRFTWEPNFWTKQLASLGCITTEGGQMSRADAPAYG 281
+ F E K + +LG I T S A G
Sbjct: 296 NDQLDFIVETEGLKKSIHNLGTILTTNAVASETVATGEG 334
>gi|194248079 tripartite motif-containing 2 isoform 1 [Homo sapiens]
Length = 771
Score = 67.8 bits (164), Expect = 6e-11
Identities = 48/219 (21%), Positives = 91/219 (41%)
Query: 63 LYCPLHTQEVLKLFCETCDMLTCHSCLVVEHKEHRCRHVEEVLQNQRMLLEGVTTQVAHK 122
L CP H V++ +C++C+ C C EH EH +++V++ + L+ V +
Sbjct: 143 LSCPNHDGNVMEFYCQSCETAMCRECTEGEHAEHPTVPLKDVVEQHKASLQVQLDAVNKR 202
Query: 123 KSSLQTSAKQIEDRIFEVKHQHRKVENQIKMAKMVLMNELNKQANGLIEELEGITNERKR 182
+ ++ + I + I ++ +Q + + I L LN + + L+ ELE + +
Sbjct: 203 LPEIDSALQFISEIIHQLTNQKASIVDDIHSTFDELQKTLNVRKSVLLMELEVNYGLKHK 262
Query: 183 KLEQQLQSIMVLNRQFEHVQNFINWAVCSKTSVPFLFSKELIVFQMQRLLETSCNTDPGS 242
L+ QL +++ + NF A+ T L K+ + ++ L + P
Sbjct: 263 VLQSQLDTLLQGQESIKSCSNFTAQALNHGTETEVLLVKKQMSEKLNELADQDFPLHPRE 322
Query: 243 PWSIRFTWEPNFWTKQLASLGCITTEGGQMSRADAPAYG 281
+ F E K + +LG I T S A G
Sbjct: 323 NDQLDFIVETEGLKKSIHNLGTILTTNAVASETVATGEG 361
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.130 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,803,640
Number of Sequences: 37866
Number of extensions: 3583218
Number of successful extensions: 64924
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 818
Number of HSP's successfully gapped in prelim test: 1160
Number of HSP's that attempted gapping in prelim test: 28170
Number of HSP's gapped (non-prelim): 16708
length of query: 1216
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1102
effective length of database: 13,930,794
effective search space: 15351734988
effective search space used: 15351734988
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.