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Search of human proteins with 209915617
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|209915617 G kinase anchoring protein 1 isoform b [Homo
sapiens]
(315 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|209915617 G kinase anchoring protein 1 isoform b [Homo sapiens] 615 e-176
gi|20127642 G kinase anchoring protein 1 isoform a [Homo sapiens] 591 e-169
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 60 2e-09
gi|31542634 filamin A interacting protein 1 [Homo sapiens] 56 5e-08
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 53 4e-07
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 53 4e-07
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 53 4e-07
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 53 4e-07
gi|8922940 gamma-taxilin [Homo sapiens] 52 7e-07
gi|156104908 myosin heavy chain 6 [Homo sapiens] 52 7e-07
gi|71061468 centromere protein E [Homo sapiens] 50 2e-06
gi|115648142 centrosomal protein 164kDa [Homo sapiens] 50 3e-06
gi|55770834 centromere protein F [Homo sapiens] 50 3e-06
gi|148746195 trichohyalin [Homo sapiens] 50 3e-06
gi|239757009 PREDICTED: ankyrin repeat domain 20 family, member ... 49 8e-06
gi|239751523 PREDICTED: ankyrin repeat domain 20 family, member ... 49 8e-06
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 49 8e-06
gi|96975038 coiled-coil domain containing 100 [Homo sapiens] 49 8e-06
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 47 2e-05
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 47 2e-05
gi|154354990 ankyrin repeat domain 26 [Homo sapiens] 47 2e-05
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 47 3e-05
gi|109134347 NY-REN-58 antigen [Homo sapiens] 47 3e-05
gi|109134355 NY-REN-58 antigen [Homo sapiens] 47 3e-05
gi|50658065 SMC4 structural maintenance of chromosomes 4-like 1 ... 47 3e-05
gi|50658063 SMC4 structural maintenance of chromosomes 4-like 1 ... 47 3e-05
gi|150010552 FK506 binding protein 15, 133kDa [Homo sapiens] 47 3e-05
gi|19924131 RAD50 homolog isoform 2 [Homo sapiens] 46 4e-05
gi|19924129 RAD50 homolog isoform 1 [Homo sapiens] 46 4e-05
gi|112420968 coiled-coil domain containing 158 [Homo sapiens] 46 4e-05
>gi|209915617 G kinase anchoring protein 1 isoform b [Homo sapiens]
Length = 315
Score = 615 bits (1586), Expect = e-176
Identities = 315/315 (100%), Positives = 315/315 (100%)
Query: 1 MASAVLSSVPTTASRFALLQVDSGSGSDSEPGKGKGRNTGKSQTLGSKSTTNEKKREKRR 60
MASAVLSSVPTTASRFALLQVDSGSGSDSEPGKGKGRNTGKSQTLGSKSTTNEKKREKRR
Sbjct: 1 MASAVLSSVPTTASRFALLQVDSGSGSDSEPGKGKGRNTGKSQTLGSKSTTNEKKREKRR 60
Query: 61 KKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDLPLSNPVQKDSREENWQEWRQRDEQ 120
KKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDLPLSNPVQKDSREENWQEWRQRDEQ
Sbjct: 61 KKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDLPLSNPVQKDSREENWQEWRQRDEQ 120
Query: 121 LTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKRKNHQGKDRPLTVS 180
LTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKRKNHQGKDRPLTVS
Sbjct: 121 LTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKRKNHQGKDRPLTVS 180
Query: 181 LKDFHSEDHISKKTEEVVLKDGRIERLKLELERKDAEIQKLKNVITQWEAKYKEVKARNA 240
LKDFHSEDHISKKTEEVVLKDGRIERLKLELERKDAEIQKLKNVITQWEAKYKEVKARNA
Sbjct: 181 LKDFHSEDHISKKTEEVVLKDGRIERLKLELERKDAEIQKLKNVITQWEAKYKEVKARNA 240
Query: 241 QLLKMLQEGEMKDKAEILLQVDESQSIKNELTIQVTSLHAALEQERSKVKVLQAELAKYQ 300
QLLKMLQEGEMKDKAEILLQVDESQSIKNELTIQVTSLHAALEQERSKVKVLQAELAKYQ
Sbjct: 241 QLLKMLQEGEMKDKAEILLQVDESQSIKNELTIQVTSLHAALEQERSKVKVLQAELAKYQ 300
Query: 301 GGRKGKRNSESDQCR 315
GGRKGKRNSESDQCR
Sbjct: 301 GGRKGKRNSESDQCR 315
>gi|20127642 G kinase anchoring protein 1 isoform a [Homo sapiens]
Length = 366
Score = 591 bits (1524), Expect = e-169
Identities = 315/366 (86%), Positives = 315/366 (86%), Gaps = 51/366 (13%)
Query: 1 MASAVLSSVPTTASRFALLQVDSGSGSDSEPGKGKGRNTGKSQTLGSKSTTNEKKREKRR 60
MASAVLSSVPTTASRFALLQVDSGSGSDSEPGKGKGRNTGKSQTLGSKSTTNEKKREKRR
Sbjct: 1 MASAVLSSVPTTASRFALLQVDSGSGSDSEPGKGKGRNTGKSQTLGSKSTTNEKKREKRR 60
Query: 61 KKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDLPLSNPVQKDSREENWQEWRQRDEQ 120
KKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDLPLSNPVQKDSREENWQEWRQRDEQ
Sbjct: 61 KKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDLPLSNPVQKDSREENWQEWRQRDEQ 120
Query: 121 LTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKRKNHQGKDRPLTVS 180
LTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKRKNHQGKDRPLTVS
Sbjct: 121 LTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKRKNHQGKDRPLTVS 180
Query: 181 LKDFHSEDHISKKTE--------------------------------------------- 195
LKDFHSEDHISKKTE
Sbjct: 181 LKDFHSEDHISKKTEELSSSQTLSHDGGFFNRLEDDVHKILIREKRREQLTEYNGTDNCT 240
Query: 196 ------EVVLKDGRIERLKLELERKDAEIQKLKNVITQWEAKYKEVKARNAQLLKMLQEG 249
EVVLKDGRIERLKLELERKDAEIQKLKNVITQWEAKYKEVKARNAQLLKMLQEG
Sbjct: 241 AHEHNQEVVLKDGRIERLKLELERKDAEIQKLKNVITQWEAKYKEVKARNAQLLKMLQEG 300
Query: 250 EMKDKAEILLQVDESQSIKNELTIQVTSLHAALEQERSKVKVLQAELAKYQGGRKGKRNS 309
EMKDKAEILLQVDESQSIKNELTIQVTSLHAALEQERSKVKVLQAELAKYQGGRKGKRNS
Sbjct: 301 EMKDKAEILLQVDESQSIKNELTIQVTSLHAALEQERSKVKVLQAELAKYQGGRKGKRNS 360
Query: 310 ESDQCR 315
ESDQCR
Sbjct: 361 ESDQCR 366
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 60.5 bits (145), Expect = 2e-09
Identities = 52/283 (18%), Positives = 130/283 (45%), Gaps = 22/283 (7%)
Query: 41 KSQTLGSKSTTNEKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDLPLSN 100
K++T+ TN+ RE++ + ++ Q ++R L +P + ++A + + +
Sbjct: 1265 KTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGM---L 1321
Query: 101 PVQKDSREENWQEWRQRDEQLTSEMFEADLEK-ALLLSKLEYEEHKKEYEDAENTSTQSK 159
+K EE+ + W+ R++ L S+ + D E+ LLS+ E + + E +++
Sbjct: 1322 QAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAE 1381
Query: 160 VMNKKDKRKNHQGKDRPLTVSLKDFHSEDHISKKTEEVVLKDGRIERLKLELERKDAEIQ 219
+ N+Q + L L +E +E + KD ++ ++++ K I
Sbjct: 1382 IARSNASLTNNQNLIQSLKEDLNKVRTE-------KETIQKD--LDAKIIDIQEKVKTIT 1432
Query: 220 KLKNVITQWEAKYKEVKARNAQLLK---------MLQEGEMKDKAEILLQVDESQSIKNE 270
++K + +++ +Y+E+KA+ ++++ Q +++ E+ ++++++
Sbjct: 1433 QVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKS 1492
Query: 271 LTIQVTSLHAALEQERSKVKVLQAELAKYQGGRKGKRNSESDQ 313
L QV +L L ++ ++ + LQ + + Q R D+
Sbjct: 1493 LESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDR 1535
Score = 41.2 bits (95), Expect = 0.001
Identities = 59/286 (20%), Positives = 120/286 (41%), Gaps = 33/286 (11%)
Query: 48 KSTTNEKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDLPLSNPVQKDSR 107
K + ++ E ++ Q+ NE R ++ + + A + + +D
Sbjct: 47 KVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRN 106
Query: 108 EENWQEWRQRDEQLTSEMFEADLEKALLLSKLEY--EEHKKEYEDA-ENTSTQSKVMNKK 164
++ + E+L +E + L +LEY E+ K+ E E+ +T+ ++ K
Sbjct: 107 IAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKL 166
Query: 165 DKRK----NHQGKDRPLTVSLKDFHSED-----HISKKTEEVVL----KDGRIERLKLEL 211
D+ + + + +++ L + HS++ + KT+E++ K I LK L
Sbjct: 167 DELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNL 226
Query: 212 ERKDAEIQKLKNVITQWEAKYKEVKARNAQLLKMLQEGE-----MKDK------AEILLQ 260
E K E+ +L+ + + + ++ LL L+E + M++K A I L
Sbjct: 227 ENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLS 286
Query: 261 ------VDESQSIKNELTIQVTSLHAALEQERSKVKVLQAELAKYQ 300
D+S++ NELT V LH L++ K +Q L + +
Sbjct: 287 NLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVE 332
Score = 40.0 bits (92), Expect = 0.003
Identities = 36/181 (19%), Positives = 86/181 (47%), Gaps = 9/181 (4%)
Query: 124 EMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKD-KRKNHQGKDRPLTVSLK 182
E +A +K + S +H++++ + + +N+ + K K+ + + L +L
Sbjct: 1446 EELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLS 1505
Query: 183 DFHSEDHISKKTEEVVLKDGRIERLKLELERKDAEIQKLKNVITQWEAK-YKEVKARNAQ 241
+ E E+ V + RL+ +L+ + + ++L+ IT+ E K K + A ++
Sbjct: 1506 E--KETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSK 1563
Query: 242 L--LKMLQEGEMKDKAEILLQVDESQSIKNELTIQVTSLHAALEQERSKVKVLQAELAKY 299
+ L +++ K+ E+ + K+EL +++T+L + Q ++ L+ EL ++
Sbjct: 1564 IAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKS---QYEGRISRLERELREH 1620
Query: 300 Q 300
Q
Sbjct: 1621 Q 1621
Score = 29.6 bits (65), Expect = 3.6
Identities = 54/205 (26%), Positives = 90/205 (43%), Gaps = 47/205 (22%)
Query: 123 SEMFEADLEKA--LLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKRKNHQGKDR---PL 177
+E++ A +E LLL KLE + K Y D ++K K +R+ ++ + L
Sbjct: 396 TELYNAYVETQDQLLLEKLENKRINK-YLDEIVKEVEAKAPILKRQREEYERAQKAVASL 454
Query: 178 TVSLKDFHSE--------DHISKKTE---------EVVLKD--GRIERLKLELER----- 213
+V L+ E D +K++ E+ +KD +I L +ELE
Sbjct: 455 SVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNH 514
Query: 214 -------KDAEIQKLKNVITQWEAKYK---EVKARNAQLLKMLQE-GEMKDKAEILLQVD 262
A+I VI+Q Y+ E++ +N +LL L+E GE +++ E
Sbjct: 515 VIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREE-----Q 569
Query: 263 ESQSIK-NELTIQVTSLHAALEQER 286
E+ S K EL +++ S LEQ R
Sbjct: 570 ETTSSKITELQLKLESALTELEQLR 594
Score = 29.6 bits (65), Expect = 3.6
Identities = 45/200 (22%), Positives = 89/200 (44%), Gaps = 24/200 (12%)
Query: 114 WRQRDEQLTSEMFEA-----DLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKRK 168
W +R+ L E+ + DLEK ++L +++ +K D S + V +
Sbjct: 1131 WEERERMLKDEVSKCVCRCEDLEKQ---NRLLHDQIEK-LSDKVVASVKEGVQGPLNVSL 1186
Query: 169 NHQGKDRPLTVSLKDF-HSEDHISKKTEEVVLKDGRIERLKLEL-ERKDAEIQKLKN--- 223
+ +GK + + + F E I++ EV + R ++EL ER+ E+Q N
Sbjct: 1187 SEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAER 1246
Query: 224 ----VITQWEAKYKEVKARNAQLLKMLQEGEM----KDKAEILLQVDESQSIKNELTIQV 275
V + A+++E+ + + +++ +M K++ E LQ + Q+ +L + +
Sbjct: 1247 EKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQ--QMQAKVRKLELDI 1304
Query: 276 TSLHAALEQERSKVKVLQAE 295
L A + K +LQAE
Sbjct: 1305 LPLQEANAELSEKSGMLQAE 1324
Score = 28.9 bits (63), Expect = 6.2
Identities = 49/262 (18%), Positives = 112/262 (42%), Gaps = 20/262 (7%)
Query: 40 GKSQTLGSKSTTNEKKREKRRKKKEQQQSEANELRNLAFK-KIPQKSSHAVCNAQHDLPL 98
G + + S N+K +K+++ + +LR K + + + + + L L
Sbjct: 734 GYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKL 793
Query: 99 SNPVQKDSREENWQEWRQRDEQLTS-EMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQ 157
S RE E R ++ LT+ + + LE++ +K ++ E E + +
Sbjct: 794 SEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEH-EISHLK 852
Query: 158 SKVMNKKDKRKN-HQGKDRPLTVSLKDFHSEDHISKKTEEVVLKDGRIERLKLELERKDA 216
K+ N+ ++R + D L + + +E ++ T+E+ L+
Sbjct: 853 KKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKEL-------------LKNAQK 899
Query: 217 EIQKLKNVITQWEAKYKEVKARNAQLLKMLQEGEMKDKAEILLQVDESQSIKNELTIQVT 276
EI LK ++ E +V ++++Q Q +D +++ Q+ +++ N+L ++
Sbjct: 900 EIATLKQHLSNMEV---QVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLK 956
Query: 277 SLHAALEQERSKVKVLQAELAK 298
+ + +EQ ++ V L+ L K
Sbjct: 957 TSTSNVEQYQAMVTSLEESLNK 978
>gi|31542634 filamin A interacting protein 1 [Homo sapiens]
Length = 1213
Score = 55.8 bits (133), Expect = 5e-08
Identities = 70/284 (24%), Positives = 131/284 (46%), Gaps = 28/284 (9%)
Query: 53 EKKREKRRKKKEQQQS--------EANELRNLAFKKIPQKSSHAVCNAQHDLPLSN-PVQ 103
E++RE+ +K EQ+++ A L L + + KS + + + + +Q
Sbjct: 205 EQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQ 264
Query: 104 KDSREENWQEWRQRDEQLTSEMFEADLEKALLLSKLEYE-EHKKEYEDAENTSTQSKVMN 162
++ Q+ R+ +E+L + ++ ++ LL KLE + EHK E+ +K+ N
Sbjct: 265 SQKVQDLTQKLREEEEKLKAITSKSKEDRQKLL-KLEVDFEHKASRFSQEHEEMNAKLAN 323
Query: 163 KKDKRKNHQGKDRPLTVSLKDFHSEDHISKKTEEVV--LKDGRIERLKLELERKDAEIQK 220
++ + + K LT +++ + +K EE + L+D +I + + AE++
Sbjct: 324 QESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRD-KIAKGECGNSSLMAEVEN 382
Query: 221 LKNVITQWEAKYKEVKARNAQ---LLKMLQEGEMKDKAEILLQVDESQSIKNELT----- 272
L+ + + E K +E+ +Q L K LQE E K E+ L+V++ Q +EL
Sbjct: 383 LRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSK-ELRLEVEKLQKRMSELEKLEEA 441
Query: 273 -----IQVTSLHAALEQERSKVKVLQAELAKYQGGRKGKRNSES 311
+ T LH LE+E++ K L EL + K SES
Sbjct: 442 FSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSES 485
Score = 32.0 bits (71), Expect = 0.73
Identities = 60/283 (21%), Positives = 119/283 (42%), Gaps = 37/283 (13%)
Query: 38 NTGKSQTLGSKSTTNEKKREKRRKKKEQQQSEANELRNLAFKK-IPQKSSHAVCNAQHDL 96
N K + L +K NE + K R K+ + E L+ K + + S V
Sbjct: 455 NLEKEKNL-TKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERK 513
Query: 97 PLSNPVQKDSREENWQEWRQRDEQ-LTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTS 155
+ ++++ R+ + + EQ ++ E +E++ L KL+ E +K Y N +
Sbjct: 514 NMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVY----NLT 569
Query: 156 TQSKVMNKKDKRKNHQGKDRPLTVSL--KDFHSEDHI--------SKKTEEVVL-KDGRI 204
+ + K K + + + +V L K + + S+K E+ +D +I
Sbjct: 570 RERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKI 629
Query: 205 ERLKLELERK----------DAEIQKLKNVITQWEAKYKEVKARNAQLLKMLQEGEMKDK 254
+ L LE+ER + ++ K ++ Q E K++ + + L + L+
Sbjct: 630 KELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLE------- 682
Query: 255 AEILLQVDESQSI-KNELTIQVTSLHAALEQERSKVKVLQAEL 296
EI Q+ ++++I K E+ Q L E +K + L+AE+
Sbjct: 683 -EIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEV 724
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 52.8 bits (125), Expect = 4e-07
Identities = 51/246 (20%), Positives = 114/246 (46%), Gaps = 13/246 (5%)
Query: 53 EKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDLPLSNPVQKDSREENWQ 112
+ K ++ +K KE+QQ NEL+ L + H+ + +L L +Q ++ E +
Sbjct: 855 QAKEDELQKTKERQQKAENELKEL-------EQKHSQLTEEKNL-LQEQLQAET--ELYA 904
Query: 113 EWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKRKNHQG 172
E + +L ++ E + + ++LE EE + + AE ++++ +++ + +
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 173 KDRPLTVSLKDFHSEDHISKKTEEVVLKDGRIERLKLELERKDAEIQKLKNVITQWEAKY 232
+ L L+ +E I K +E+++ D + +L E + + I L + + E K
Sbjct: 965 ARQKL--QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1022
Query: 233 KEVKARNAQLLKMLQEGEMKDKAEILLQVDESQSIKNELTIQVTSLHAALEQERSKVKVL 292
K + + M+ E E++ K E + E + +K +L + H + ++++ L
Sbjct: 1023 KNLTKLKNKHESMISELEVRLKKEEKSR-QELEKLKRKLEGDASDFHEQIADLQAQIAEL 1081
Query: 293 QAELAK 298
+ +LAK
Sbjct: 1082 KMQLAK 1087
Score = 40.4 bits (93), Expect = 0.002
Identities = 28/102 (27%), Positives = 57/102 (55%), Gaps = 6/102 (5%)
Query: 203 RIERLKLELERKDAEIQKLKNVITQWEAKYKEVKARNAQLL--KMLQEGEMKDKAEILLQ 260
++ R + E++ K+ E+QK K + E + KE++ +++QL K L + +++ + E+ +
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 261 VDESQ----SIKNELTIQVTSLHAALEQERSKVKVLQAELAK 298
+E + + K EL + + A LE+E + + LQAE K
Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK 947
Score = 37.7 bits (86), Expect = 0.013
Identities = 64/301 (21%), Positives = 122/301 (40%), Gaps = 50/301 (16%)
Query: 53 EKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDLPLSNPVQKDSREENWQ 112
+KK E K E Q A + R A K++ +K + + Q +L + + SR+E +
Sbjct: 1619 KKKLEGDLKDLELQADSAIKGREEAIKQL-RKLQAQMKDFQRELEDA----RASRDEIFA 1673
Query: 113 EWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKRKNHQG 172
++ +++ S EADL + L L E ++ D E ++ + R Q
Sbjct: 1674 TAKENEKKAKS--LEADLMQ--LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD 1729
Query: 173 KDRPLTVSLKDFHSE------------DHISKKTEEVVLKDGRI----------ERLKLE 210
+ R L + E D + K T++ + E + +
Sbjct: 1730 EKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQ 1789
Query: 211 LERKDAEIQ------------KLKNVITQWEAKYKEVKARNAQLLKMLQEG----EMKDK 254
LER++ E++ K K+ I EAK +++ + Q + Q + KDK
Sbjct: 1790 LERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1849
Query: 255 A--EILLQVDESQSIKNELTIQVTSLHAALEQERSKVKVLQAELAKYQGGRKGKRNSESD 312
EILLQV++ + + + Q +A ++Q + +++ + E + R+ K E D
Sbjct: 1850 KLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR-KLQRELD 1908
Query: 313 Q 313
+
Sbjct: 1909 E 1909
Score = 35.8 bits (81), Expect = 0.051
Identities = 52/262 (19%), Positives = 113/262 (43%), Gaps = 25/262 (9%)
Query: 49 STTNEKKREKRRKKKE-QQQSEANELRNLAFKKIPQKSSHAVCNAQHDLPLSNPVQKDSR 107
ST + K+R +KE + ++ E + A+ K+ +K+ + + DL + Q+
Sbjct: 1385 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL-EKTKNRLQQELDDLVVDLDNQRQL- 1442
Query: 108 EENWQEWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKR 167
N ++ +++ +QL +E + A + E E +KE + + + K++
Sbjct: 1443 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1502
Query: 168 KNHQGKDRPLTVSLKDF-HSEDHISKKTEEVVLK----DGRIERLKLELERKDAEIQKLK 222
+ ++ L ++D S+D + K E+ + ++E +K +LE + E+Q +
Sbjct: 1503 ER---TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATE 1559
Query: 223 NVITQWEAKYKEVKARNAQLLKMLQEGEMKDKAEILLQVDESQSIKNELTIQVTSLHAAL 282
+ + E N Q LK E +++ + E +++ + +L Q+ L
Sbjct: 1560 DAKLRLEV--------NMQALKGQFERDLQARDE------QNEEKRRQLQRQLHEYETEL 1605
Query: 283 EQERSKVKVLQAELAKYQGGRK 304
E ER + + A K +G K
Sbjct: 1606 EDERKQRALAAAAKKKLEGDLK 1627
Score = 32.7 bits (73), Expect = 0.43
Identities = 39/198 (19%), Positives = 87/198 (43%), Gaps = 9/198 (4%)
Query: 120 QLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKRKNHQGKDRPLTV 179
Q FE DL+ ++ E E K+ + ++++ +++ +R + L
Sbjct: 1570 QALKGQFERDLQ-----ARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1624
Query: 180 SLKDFHSE-DHISKKTEEVVLKDGRIERLKLELERKDAEIQKLKNVITQWEAKYKEVKAR 238
LKD + D K EE + + +++ + +R+ + + ++ I AK E KA+
Sbjct: 1625 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFA-TAKENEKKAK 1683
Query: 239 NAQLLKMLQEGEMKDKAEILLQVD-ESQSIKNELTIQVTSLHAALEQERSKVKVLQAELA 297
+ + M + ++ Q D E + + EL ++ + AL+ E+ +++ A+L
Sbjct: 1684 SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN-ALQDEKRRLEARIAQLE 1742
Query: 298 KYQGGRKGKRNSESDQCR 315
+ +G + SD+ R
Sbjct: 1743 EELEEEQGNMEAMSDRVR 1760
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 52.8 bits (125), Expect = 4e-07
Identities = 51/246 (20%), Positives = 114/246 (46%), Gaps = 13/246 (5%)
Query: 53 EKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDLPLSNPVQKDSREENWQ 112
+ K ++ +K KE+QQ NEL+ L + H+ + +L L +Q ++ E +
Sbjct: 862 QAKEDELQKTKERQQKAENELKEL-------EQKHSQLTEEKNL-LQEQLQAET--ELYA 911
Query: 113 EWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKRKNHQG 172
E + +L ++ E + + ++LE EE + + AE ++++ +++ + +
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971
Query: 173 KDRPLTVSLKDFHSEDHISKKTEEVVLKDGRIERLKLELERKDAEIQKLKNVITQWEAKY 232
+ L L+ +E I K +E+++ D + +L E + + I L + + E K
Sbjct: 972 ARQKL--QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1029
Query: 233 KEVKARNAQLLKMLQEGEMKDKAEILLQVDESQSIKNELTIQVTSLHAALEQERSKVKVL 292
K + + M+ E E++ K E + E + +K +L + H + ++++ L
Sbjct: 1030 KNLTKLKNKHESMISELEVRLKKEEKSR-QELEKLKRKLEGDASDFHEQIADLQAQIAEL 1088
Query: 293 QAELAK 298
+ +LAK
Sbjct: 1089 KMQLAK 1094
Score = 40.4 bits (93), Expect = 0.002
Identities = 28/102 (27%), Positives = 57/102 (55%), Gaps = 6/102 (5%)
Query: 203 RIERLKLELERKDAEIQKLKNVITQWEAKYKEVKARNAQLL--KMLQEGEMKDKAEILLQ 260
++ R + E++ K+ E+QK K + E + KE++ +++QL K L + +++ + E+ +
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 261 VDESQ----SIKNELTIQVTSLHAALEQERSKVKVLQAELAK 298
+E + + K EL + + A LE+E + + LQAE K
Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK 954
Score = 37.7 bits (86), Expect = 0.013
Identities = 64/301 (21%), Positives = 122/301 (40%), Gaps = 50/301 (16%)
Query: 53 EKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDLPLSNPVQKDSREENWQ 112
+KK E K E Q A + R A K++ +K + + Q +L + + SR+E +
Sbjct: 1626 KKKLEGDLKDLELQADSAIKGREEAIKQL-RKLQAQMKDFQRELEDA----RASRDEIFA 1680
Query: 113 EWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKRKNHQG 172
++ +++ S EADL + L L E ++ D E ++ + R Q
Sbjct: 1681 TAKENEKKAKS--LEADLMQ--LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD 1736
Query: 173 KDRPLTVSLKDFHSE------------DHISKKTEEVVLKDGRI----------ERLKLE 210
+ R L + E D + K T++ + E + +
Sbjct: 1737 EKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQ 1796
Query: 211 LERKDAEIQ------------KLKNVITQWEAKYKEVKARNAQLLKMLQEG----EMKDK 254
LER++ E++ K K+ I EAK +++ + Q + Q + KDK
Sbjct: 1797 LERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1856
Query: 255 A--EILLQVDESQSIKNELTIQVTSLHAALEQERSKVKVLQAELAKYQGGRKGKRNSESD 312
EILLQV++ + + + Q +A ++Q + +++ + E + R+ K E D
Sbjct: 1857 KLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR-KLQRELD 1915
Query: 313 Q 313
+
Sbjct: 1916 E 1916
Score = 35.8 bits (81), Expect = 0.051
Identities = 52/262 (19%), Positives = 113/262 (43%), Gaps = 25/262 (9%)
Query: 49 STTNEKKREKRRKKKE-QQQSEANELRNLAFKKIPQKSSHAVCNAQHDLPLSNPVQKDSR 107
ST + K+R +KE + ++ E + A+ K+ +K+ + + DL + Q+
Sbjct: 1392 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL-EKTKNRLQQELDDLVVDLDNQRQL- 1449
Query: 108 EENWQEWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKR 167
N ++ +++ +QL +E + A + E E +KE + + + K++
Sbjct: 1450 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1509
Query: 168 KNHQGKDRPLTVSLKDF-HSEDHISKKTEEVVLK----DGRIERLKLELERKDAEIQKLK 222
+ ++ L ++D S+D + K E+ + ++E +K +LE + E+Q +
Sbjct: 1510 ER---TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATE 1566
Query: 223 NVITQWEAKYKEVKARNAQLLKMLQEGEMKDKAEILLQVDESQSIKNELTIQVTSLHAAL 282
+ + E N Q LK E +++ + E +++ + +L Q+ L
Sbjct: 1567 DAKLRLEV--------NMQALKGQFERDLQARDE------QNEEKRRQLQRQLHEYETEL 1612
Query: 283 EQERSKVKVLQAELAKYQGGRK 304
E ER + + A K +G K
Sbjct: 1613 EDERKQRALAAAAKKKLEGDLK 1634
Score = 32.7 bits (73), Expect = 0.43
Identities = 39/198 (19%), Positives = 87/198 (43%), Gaps = 9/198 (4%)
Query: 120 QLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKRKNHQGKDRPLTV 179
Q FE DL+ ++ E E K+ + ++++ +++ +R + L
Sbjct: 1577 QALKGQFERDLQ-----ARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1631
Query: 180 SLKDFHSE-DHISKKTEEVVLKDGRIERLKLELERKDAEIQKLKNVITQWEAKYKEVKAR 238
LKD + D K EE + + +++ + +R+ + + ++ I AK E KA+
Sbjct: 1632 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFA-TAKENEKKAK 1690
Query: 239 NAQLLKMLQEGEMKDKAEILLQVD-ESQSIKNELTIQVTSLHAALEQERSKVKVLQAELA 297
+ + M + ++ Q D E + + EL ++ + AL+ E+ +++ A+L
Sbjct: 1691 SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN-ALQDEKRRLEARIAQLE 1749
Query: 298 KYQGGRKGKRNSESDQCR 315
+ +G + SD+ R
Sbjct: 1750 EELEEEQGNMEAMSDRVR 1767
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 52.8 bits (125), Expect = 4e-07
Identities = 51/246 (20%), Positives = 114/246 (46%), Gaps = 13/246 (5%)
Query: 53 EKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDLPLSNPVQKDSREENWQ 112
+ K ++ +K KE+QQ NEL+ L + H+ + +L L +Q ++ E +
Sbjct: 862 QAKEDELQKTKERQQKAENELKEL-------EQKHSQLTEEKNL-LQEQLQAET--ELYA 911
Query: 113 EWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKRKNHQG 172
E + +L ++ E + + ++LE EE + + AE ++++ +++ + +
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971
Query: 173 KDRPLTVSLKDFHSEDHISKKTEEVVLKDGRIERLKLELERKDAEIQKLKNVITQWEAKY 232
+ L L+ +E I K +E+++ D + +L E + + I L + + E K
Sbjct: 972 ARQKL--QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1029
Query: 233 KEVKARNAQLLKMLQEGEMKDKAEILLQVDESQSIKNELTIQVTSLHAALEQERSKVKVL 292
K + + M+ E E++ K E + E + +K +L + H + ++++ L
Sbjct: 1030 KNLTKLKNKHESMISELEVRLKKEEKSR-QELEKLKRKLEGDASDFHEQIADLQAQIAEL 1088
Query: 293 QAELAK 298
+ +LAK
Sbjct: 1089 KMQLAK 1094
Score = 40.4 bits (93), Expect = 0.002
Identities = 28/102 (27%), Positives = 57/102 (55%), Gaps = 6/102 (5%)
Query: 203 RIERLKLELERKDAEIQKLKNVITQWEAKYKEVKARNAQLL--KMLQEGEMKDKAEILLQ 260
++ R + E++ K+ E+QK K + E + KE++ +++QL K L + +++ + E+ +
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 261 VDESQ----SIKNELTIQVTSLHAALEQERSKVKVLQAELAK 298
+E + + K EL + + A LE+E + + LQAE K
Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK 954
Score = 37.7 bits (86), Expect = 0.013
Identities = 64/301 (21%), Positives = 122/301 (40%), Gaps = 50/301 (16%)
Query: 53 EKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDLPLSNPVQKDSREENWQ 112
+KK E K E Q A + R A K++ +K + + Q +L + + SR+E +
Sbjct: 1626 KKKLEGDLKDLELQADSAIKGREEAIKQL-RKLQAQMKDFQRELEDA----RASRDEIFA 1680
Query: 113 EWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKRKNHQG 172
++ +++ S EADL + L L E ++ D E ++ + R Q
Sbjct: 1681 TAKENEKKAKS--LEADLMQ--LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD 1736
Query: 173 KDRPLTVSLKDFHSE------------DHISKKTEEVVLKDGRI----------ERLKLE 210
+ R L + E D + K T++ + E + +
Sbjct: 1737 EKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQ 1796
Query: 211 LERKDAEIQ------------KLKNVITQWEAKYKEVKARNAQLLKMLQEG----EMKDK 254
LER++ E++ K K+ I EAK +++ + Q + Q + KDK
Sbjct: 1797 LERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1856
Query: 255 A--EILLQVDESQSIKNELTIQVTSLHAALEQERSKVKVLQAELAKYQGGRKGKRNSESD 312
EILLQV++ + + + Q +A ++Q + +++ + E + R+ K E D
Sbjct: 1857 KLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR-KLQRELD 1915
Query: 313 Q 313
+
Sbjct: 1916 E 1916
Score = 35.8 bits (81), Expect = 0.051
Identities = 52/262 (19%), Positives = 113/262 (43%), Gaps = 25/262 (9%)
Query: 49 STTNEKKREKRRKKKE-QQQSEANELRNLAFKKIPQKSSHAVCNAQHDLPLSNPVQKDSR 107
ST + K+R +KE + ++ E + A+ K+ +K+ + + DL + Q+
Sbjct: 1392 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL-EKTKNRLQQELDDLVVDLDNQRQL- 1449
Query: 108 EENWQEWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKR 167
N ++ +++ +QL +E + A + E E +KE + + + K++
Sbjct: 1450 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1509
Query: 168 KNHQGKDRPLTVSLKDF-HSEDHISKKTEEVVLK----DGRIERLKLELERKDAEIQKLK 222
+ ++ L ++D S+D + K E+ + ++E +K +LE + E+Q +
Sbjct: 1510 ER---TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATE 1566
Query: 223 NVITQWEAKYKEVKARNAQLLKMLQEGEMKDKAEILLQVDESQSIKNELTIQVTSLHAAL 282
+ + E N Q LK E +++ + E +++ + +L Q+ L
Sbjct: 1567 DAKLRLEV--------NMQALKGQFERDLQARDE------QNEEKRRQLQRQLHEYETEL 1612
Query: 283 EQERSKVKVLQAELAKYQGGRK 304
E ER + + A K +G K
Sbjct: 1613 EDERKQRALAAAAKKKLEGDLK 1634
Score = 32.7 bits (73), Expect = 0.43
Identities = 39/198 (19%), Positives = 87/198 (43%), Gaps = 9/198 (4%)
Query: 120 QLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKRKNHQGKDRPLTV 179
Q FE DL+ ++ E E K+ + ++++ +++ +R + L
Sbjct: 1577 QALKGQFERDLQ-----ARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1631
Query: 180 SLKDFHSE-DHISKKTEEVVLKDGRIERLKLELERKDAEIQKLKNVITQWEAKYKEVKAR 238
LKD + D K EE + + +++ + +R+ + + ++ I AK E KA+
Sbjct: 1632 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFA-TAKENEKKAK 1690
Query: 239 NAQLLKMLQEGEMKDKAEILLQVD-ESQSIKNELTIQVTSLHAALEQERSKVKVLQAELA 297
+ + M + ++ Q D E + + EL ++ + AL+ E+ +++ A+L
Sbjct: 1691 SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN-ALQDEKRRLEARIAQLE 1749
Query: 298 KYQGGRKGKRNSESDQCR 315
+ +G + SD+ R
Sbjct: 1750 EELEEEQGNMEAMSDRVR 1767
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 52.8 bits (125), Expect = 4e-07
Identities = 51/246 (20%), Positives = 114/246 (46%), Gaps = 13/246 (5%)
Query: 53 EKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDLPLSNPVQKDSREENWQ 112
+ K ++ +K KE+QQ NEL+ L + H+ + +L L +Q ++ E +
Sbjct: 855 QAKEDELQKTKERQQKAENELKEL-------EQKHSQLTEEKNL-LQEQLQAET--ELYA 904
Query: 113 EWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKRKNHQG 172
E + +L ++ E + + ++LE EE + + AE ++++ +++ + +
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 173 KDRPLTVSLKDFHSEDHISKKTEEVVLKDGRIERLKLELERKDAEIQKLKNVITQWEAKY 232
+ L L+ +E I K +E+++ D + +L E + + I L + + E K
Sbjct: 965 ARQKL--QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1022
Query: 233 KEVKARNAQLLKMLQEGEMKDKAEILLQVDESQSIKNELTIQVTSLHAALEQERSKVKVL 292
K + + M+ E E++ K E + E + +K +L + H + ++++ L
Sbjct: 1023 KNLTKLKNKHESMISELEVRLKKEEKSR-QELEKLKRKLEGDASDFHEQIADLQAQIAEL 1081
Query: 293 QAELAK 298
+ +LAK
Sbjct: 1082 KMQLAK 1087
Score = 40.4 bits (93), Expect = 0.002
Identities = 28/102 (27%), Positives = 57/102 (55%), Gaps = 6/102 (5%)
Query: 203 RIERLKLELERKDAEIQKLKNVITQWEAKYKEVKARNAQLL--KMLQEGEMKDKAEILLQ 260
++ R + E++ K+ E+QK K + E + KE++ +++QL K L + +++ + E+ +
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 261 VDESQ----SIKNELTIQVTSLHAALEQERSKVKVLQAELAK 298
+E + + K EL + + A LE+E + + LQAE K
Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK 947
Score = 37.7 bits (86), Expect = 0.013
Identities = 64/301 (21%), Positives = 122/301 (40%), Gaps = 50/301 (16%)
Query: 53 EKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDLPLSNPVQKDSREENWQ 112
+KK E K E Q A + R A K++ +K + + Q +L + + SR+E +
Sbjct: 1619 KKKLEGDLKDLELQADSAIKGREEAIKQL-RKLQAQMKDFQRELEDA----RASRDEIFA 1673
Query: 113 EWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKRKNHQG 172
++ +++ S EADL + L L E ++ D E ++ + R Q
Sbjct: 1674 TAKENEKKAKS--LEADLMQ--LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD 1729
Query: 173 KDRPLTVSLKDFHSE------------DHISKKTEEVVLKDGRI----------ERLKLE 210
+ R L + E D + K T++ + E + +
Sbjct: 1730 EKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQ 1789
Query: 211 LERKDAEIQ------------KLKNVITQWEAKYKEVKARNAQLLKMLQEG----EMKDK 254
LER++ E++ K K+ I EAK +++ + Q + Q + KDK
Sbjct: 1790 LERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1849
Query: 255 A--EILLQVDESQSIKNELTIQVTSLHAALEQERSKVKVLQAELAKYQGGRKGKRNSESD 312
EILLQV++ + + + Q +A ++Q + +++ + E + R+ K E D
Sbjct: 1850 KLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR-KLQRELD 1908
Query: 313 Q 313
+
Sbjct: 1909 E 1909
Score = 35.8 bits (81), Expect = 0.051
Identities = 52/262 (19%), Positives = 113/262 (43%), Gaps = 25/262 (9%)
Query: 49 STTNEKKREKRRKKKE-QQQSEANELRNLAFKKIPQKSSHAVCNAQHDLPLSNPVQKDSR 107
ST + K+R +KE + ++ E + A+ K+ +K+ + + DL + Q+
Sbjct: 1385 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL-EKTKNRLQQELDDLVVDLDNQRQL- 1442
Query: 108 EENWQEWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKR 167
N ++ +++ +QL +E + A + E E +KE + + + K++
Sbjct: 1443 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1502
Query: 168 KNHQGKDRPLTVSLKDF-HSEDHISKKTEEVVLK----DGRIERLKLELERKDAEIQKLK 222
+ ++ L ++D S+D + K E+ + ++E +K +LE + E+Q +
Sbjct: 1503 ER---TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATE 1559
Query: 223 NVITQWEAKYKEVKARNAQLLKMLQEGEMKDKAEILLQVDESQSIKNELTIQVTSLHAAL 282
+ + E N Q LK E +++ + E +++ + +L Q+ L
Sbjct: 1560 DAKLRLEV--------NMQALKGQFERDLQARDE------QNEEKRRQLQRQLHEYETEL 1605
Query: 283 EQERSKVKVLQAELAKYQGGRK 304
E ER + + A K +G K
Sbjct: 1606 EDERKQRALAAAAKKKLEGDLK 1627
Score = 32.7 bits (73), Expect = 0.43
Identities = 39/198 (19%), Positives = 87/198 (43%), Gaps = 9/198 (4%)
Query: 120 QLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKRKNHQGKDRPLTV 179
Q FE DL+ ++ E E K+ + ++++ +++ +R + L
Sbjct: 1570 QALKGQFERDLQ-----ARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1624
Query: 180 SLKDFHSE-DHISKKTEEVVLKDGRIERLKLELERKDAEIQKLKNVITQWEAKYKEVKAR 238
LKD + D K EE + + +++ + +R+ + + ++ I AK E KA+
Sbjct: 1625 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFA-TAKENEKKAK 1683
Query: 239 NAQLLKMLQEGEMKDKAEILLQVD-ESQSIKNELTIQVTSLHAALEQERSKVKVLQAELA 297
+ + M + ++ Q D E + + EL ++ + AL+ E+ +++ A+L
Sbjct: 1684 SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN-ALQDEKRRLEARIAQLE 1742
Query: 298 KYQGGRKGKRNSESDQCR 315
+ +G + SD+ R
Sbjct: 1743 EELEEEQGNMEAMSDRVR 1760
>gi|8922940 gamma-taxilin [Homo sapiens]
Length = 528
Score = 52.0 bits (123), Expect = 7e-07
Identities = 63/260 (24%), Positives = 126/260 (48%), Gaps = 33/260 (12%)
Query: 51 TNEKKREKRRKKKEQQQSEANELRNLAFKKIP-QKSSHAVCNA---QHDLPLSNPVQK-- 104
T +++ ++ +++E+++ EA + +I Q H + NA Q ++ L ++K
Sbjct: 221 TLKEENMQQAREEEERRKEATAHFQITLDEIQAQLEQHDIHNAKLRQENIELGEKLKKLI 280
Query: 105 ---DSREENWQEWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVM 161
REE+ + +R E L ++ +A L++ L K E+H++E E +T+S+
Sbjct: 281 EQYALREEHIDKVFKRKE-LQQQLVDAKLQQTTQLIKEADEKHQREREFLLKEATESRHK 339
Query: 162 NKKDKRKNHQGKDRPLTVSLKDFHSEDHISKKTEEVVLKDGRIERLKLELERKDAEIQKL 221
++ K++ Q K + L++ + F K+ E+ + E+E+ +I+KL
Sbjct: 340 YEQMKQQEVQLKQQ-LSLYMDKFEEFQTTMAKSNEL------FTTFRQEMEKMTKKIKKL 392
Query: 222 KNVITQWEAKYKEVKARNAQLLKMLQEGEMKDKAEILLQVDESQSIKNELTIQVTSLHAA 281
+ W K++ N LL+M +E ++DK LQ IK E ++ L A
Sbjct: 393 EKETIIWRTKWEN---NNKALLQMAEEKTVRDKEYKALQ------IKLE---RLEKLCRA 440
Query: 282 LEQERS----KVKVLQAELA 297
L+ ER+ KV+VL+ +++
Sbjct: 441 LQTERNELNEKVEVLKEQVS 460
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 52.0 bits (123), Expect = 7e-07
Identities = 59/285 (20%), Positives = 130/285 (45%), Gaps = 29/285 (10%)
Query: 41 KSQTLGSKSTTNEKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDLPL-- 98
K +T + T ++ +K+ ++ Q EA E N + +K+ H + N DL +
Sbjct: 1376 KYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSL-EKTKHRLQNEIEDLMVDV 1434
Query: 99 --SNPVQK--DSREENWQ----EWRQRDEQLTSEMFEADLEKALLLSKL-----EYEEHK 145
SN D ++ N+ EW+Q+ E+ SE+ + E L ++L YEE
Sbjct: 1435 ERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESL 1494
Query: 146 KEYED--AENTSTQSKVMNKKDK-----RKNHQGKDRPLTVSLKDFHSEDHISKKTEEVV 198
+ E EN + Q ++ + ++ + H+ + + ++ + + + +
Sbjct: 1495 EHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLE 1554
Query: 199 LKDGRIERLKLELERKDAEIQKLKNVITQWEAKYKEVKARNAQLLKMLQ---EGEMKDKA 255
++G+I R +LE + AEI++ + + + + ++ K + +++ LQ + E + +
Sbjct: 1555 HEEGKILRAQLEFNQIKAEIERK---LAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRN 1611
Query: 256 EILLQVDESQSIKNELTIQVTSLHAALEQERSKVKVLQAELAKYQ 300
E+L + + NE+ IQ++ + + + +VK LQ+ L Q
Sbjct: 1612 EVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQ 1656
Score = 37.0 bits (84), Expect = 0.023
Identities = 48/221 (21%), Positives = 94/221 (42%), Gaps = 48/221 (21%)
Query: 54 KKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDLPLSNPVQKDSREENWQE 113
++ E+ RK EQ+ E +E L + + ++ N + + + EE QE
Sbjct: 1695 EQTERSRKLAEQELIETSERVQLLHSQ-----NTSLINQKKKMESDLTQLQSEVEEAVQE 1749
Query: 114 WRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKRKNHQGK 173
R +E+ +KA+ + + EE KKE + + + K M +
Sbjct: 1750 CRNAEEKA---------KKAITDAAMMAEELKKEQDTSAHLERMKKNMEQ---------- 1790
Query: 174 DRPLTVSLKDFHSEDHISKKTEEVVLKDGRIERLKLELERKDAEIQKLKNVITQWEAKYK 233
++KD H + E++ LK G+ ++QKL+ + + E + +
Sbjct: 1791 ------TIKDLQ---HRLDEAEQIALKGGK------------KQLQKLEARVRELEGELE 1829
Query: 234 EVKARNAQLLKMLQEGEMKDKAEILLQVDESQSIKNELTIQ 274
+ RNA+ +K +++ E + K E+ Q +E + KN L +Q
Sbjct: 1830 AEQKRNAESVKGMRKSERRIK-ELTYQTEEDK--KNLLRLQ 1867
Score = 28.5 bits (62), Expect = 8.1
Identities = 27/109 (24%), Positives = 53/109 (48%), Gaps = 9/109 (8%)
Query: 198 VLKDGRIERLKLELERKDAEIQKLKNVITQWEAKYKEVKARNAQLLKMLQEGEMKDKAE- 256
+LK E+ E+ E ++K + + EA+ KE++ + LL+ + +++ +AE
Sbjct: 841 LLKSAETEK---EMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQ 897
Query: 257 -ILLQVDE--SQSIKNELTIQ--VTSLHAALEQERSKVKVLQAELAKYQ 300
L +E Q IKN++ ++ V ++ LE E L A+ K +
Sbjct: 898 DNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLE 946
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 50.4 bits (119), Expect = 2e-06
Identities = 58/277 (20%), Positives = 126/277 (45%), Gaps = 19/277 (6%)
Query: 35 KGRNTGKSQTLGSKSTTNEKKREKRRKKKEQQQ--SEANELRNLAFKKIPQKSSHA-VCN 91
+G+ T + L + NE RE+ E + SE LR K+I KS +
Sbjct: 719 EGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLR----KEIQDKSEELHIIT 774
Query: 92 AQHDLPLSNPVQKDSREENWQE--WRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYE 149
++ D S V K+SR + E + +D+ T++ ++ K + + +++Y+
Sbjct: 775 SEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYK 834
Query: 150 DA--ENTSTQSKVMNKKDKRKNHQGKDRPLTVSLKDFHSEDHISKKTEEVVLKDGRIERL 207
EN +++N + + L L + + +KT EV + +E+L
Sbjct: 835 MVLEENERMNQEIVNLSKEAQKFDSSLGALKTELS--YKTQELQEKTREVQERLNEMEQL 892
Query: 208 KLELERKDAEIQKL---KNVITQ-WEAKYKEVKARNAQL--LKMLQEGEMKDKAEILLQV 261
K +LE +D+ +Q + K +IT+ + +EVK + LK LQE ++ ++ +
Sbjct: 893 KEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDI 952
Query: 262 DESQSIKNELTIQVTSLHAALEQERSKVKVLQAELAK 298
++ ++ + Q+ + +L+Q + + L++++++
Sbjct: 953 HDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISE 989
Score = 45.4 bits (106), Expect = 6e-05
Identities = 46/186 (24%), Positives = 87/186 (46%), Gaps = 27/186 (14%)
Query: 102 VQKDSREENWQEWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVM 161
+++D +E+ QE + RD ++ E L+ A +LSK EHK E D K +
Sbjct: 1903 LERDQLKESLQETKARDLEIQQE-----LKTARMLSK----EHK-ETVDKLREKISEKTI 1952
Query: 162 NKKDKRKNHQGKDRPLTVSLKDFHSEDHISKKTEEVVLKDGRIERLKLELERKDAEIQKL 221
D +K+ S+D + KK +E+ K+ ++ R+K ++ +I ++
Sbjct: 1953 QISDIQKDLD-------------KSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEM 1999
Query: 222 KNVITQWEAK---YKEVKARNAQLLKMLQEGEMKDKAEILLQVDESQSIKNELTIQVTSL 278
+ + Q+EA+ + V+ N QL K L E +++ + + DE + IK L ++
Sbjct: 2000 EQLKKQFEAQNLSMQSVRMDNFQLTKKLHE-SLEEIRIVAKERDELRRIKESLKMERDQF 2058
Query: 279 HAALEQ 284
A L +
Sbjct: 2059 IATLRE 2064
Score = 42.4 bits (98), Expect = 5e-04
Identities = 54/248 (21%), Positives = 104/248 (41%), Gaps = 30/248 (12%)
Query: 43 QTLGSKSTTNEKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDL------ 96
Q+ STT + +R + E+ Q E+++L ++ K+ +HD
Sbjct: 1314 QSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIR 1373
Query: 97 -PLSNPVQKDSREENWQEWRQRDEQLTSEMFEADLEK----ALLLSKLEYEEHKKEYEDA 151
L+ + S++E +++D + T + E + K ALL ++E K +++
Sbjct: 1374 ETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQES 1433
Query: 152 ENTSTQSKVMNKKDKRKNH---QGKDRPLTVSLKDF---HSEDHISKKTEEVVLKDGR-- 203
+ +S K D ++ Q + L ++K+ H E K LK+
Sbjct: 1434 HD-EMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEET 1492
Query: 204 IERLKLELERKDAEIQKLKNVITQWEAKYKEVKARNAQLLKMLQEGEMKDKAEILLQVDE 263
I L++ L K+ EI ++ K+++A N +L +QE K++ + Q+ E
Sbjct: 1493 INELRVNLSEKETEISTIQ----------KQLEAINDKLQNKIQEIYEKEEQFNIKQISE 1542
Query: 264 SQSIKNEL 271
Q NEL
Sbjct: 1543 VQEKVNEL 1550
Score = 38.5 bits (88), Expect = 0.008
Identities = 57/263 (21%), Positives = 108/263 (41%), Gaps = 48/263 (18%)
Query: 48 KSTTNEKKREKRRKKKEQQQS--EANELRNLAFKKIPQKSSHAVCNAQHDLPLSNPVQKD 105
+S KK+ + +KE Q + E +L +L K+P+ +CN + + +++ +QK+
Sbjct: 673 QSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKD---LLCNLELEGKITD-LQKE 728
Query: 106 SREENWQEWRQRDEQLTSEMFEADLEKALLLSKL-----EYEEHKKEYEDAENTSTQSKV 160
+E E EA E+ +LLS+L E E +KE +D + +
Sbjct: 729 LNKE-------------VEENEALREEVILLSELKSLPSEVERLRKEIQD--KSEELHII 773
Query: 161 MNKKDKRKNHQGKDRPLTVSLKDFHSEDHISKKTEEVVLKDGRIERLKLELERKDAEIQK 220
++KDK + + H E + EE+ + + + D E Q
Sbjct: 774 TSEKDK------------LFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQN 821
Query: 221 LKNVITQWEAKYKEV----KARNAQLLKMLQEGEMKD------KAEILLQVDESQSIKNE 270
K + +E KYK V + N +++ + +E + D K E+ + E Q E
Sbjct: 822 FKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTRE 881
Query: 271 LTIQVTSLHAALEQERSKVKVLQ 293
+ ++ + EQ ++ LQ
Sbjct: 882 VQERLNEMEQLKEQLENRDSTLQ 904
Score = 35.0 bits (79), Expect = 0.087
Identities = 53/289 (18%), Positives = 121/289 (41%), Gaps = 65/289 (22%)
Query: 42 SQTLGSKSTTNEKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDL---PL 98
S+T + EK +EK ++ +E+QQ N ++ QK + + N +++L L
Sbjct: 1116 SRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEM---QKKINEIENLKNELKNKEL 1172
Query: 99 SNPVQKDSREENWQEWRQRDEQLTS------------EMFEAD----------------- 129
+ + R E Q+ + E++ S + FE +
Sbjct: 1173 TLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQ 1232
Query: 130 LEKALLLSKLEYEEHKKEYEDAENTSTQ--SKVMNKKDKRKNHQ---------GKDRPLT 178
++ L ++ + +EH++ ++ + ++ ++++N +D K+H +++ L
Sbjct: 1233 TKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELL 1292
Query: 179 VSLKDF----HSEDHISKKTEEVVLKD----GRIERLKLELERKDAEIQK---------- 220
++K+ + + + TE+ KD RIE +L L K E Q+
Sbjct: 1293 PNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERD 1352
Query: 221 -LKNVITQWEAKYKEVKARNAQLLKMLQEGEMKDKAEILLQVDESQSIK 268
LK + E K+ ++K + L +QE + K + + ++ ++++ K
Sbjct: 1353 NLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTK 1401
Score = 34.3 bits (77), Expect = 0.15
Identities = 56/284 (19%), Positives = 121/284 (42%), Gaps = 54/284 (19%)
Query: 28 DSEPGKGKGRNTGKSQTLGSKSTTNEKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSH 87
DS G K + K+Q L K+ +++ + + KEQ ++ + L+ +
Sbjct: 858 DSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTV----------- 906
Query: 88 AVCNAQHDLPLSNPVQKDSREENWQEWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKE 147
+K E Q+ + + LT E + DL++ ++E ++ K +
Sbjct: 907 -------------EREKTLITEKLQQTLEEVKTLTQE--KDDLKQLQESLQIERDQLKSD 951
Query: 148 YEDAENTS--TQSKVMNKKDKRKNHQGKDRPLTVSL-----KDFHSEDHISKKTEEVVLK 200
D N + TQ ++ N + K HQ L + ++ H E++ + +E K
Sbjct: 952 IHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQK 1011
Query: 201 DGRIERLKLELERKDAEIQKLKNVITQWEAKYKEVKARNAQLLKMLQEGEMKDKAEILLQ 260
I++ K +LE K+ + + K E+ + ++ ++QE K++ + +L+
Sbjct: 1012 MVGIDK-KQDLEAKNTQTLTA-------DVKDNEIIEQQRKIFSLIQE---KNELQQMLE 1060
Query: 261 --VDESQSIKNEL--TIQVTSLHAALEQERSKVKVLQAELAKYQ 300
+ E + +K +L I++T + + ++++L EL K Q
Sbjct: 1061 SVIAEKEQLKTDLKENIEMTI------ENQEELRLLGDELKKQQ 1098
Score = 33.1 bits (74), Expect = 0.33
Identities = 57/307 (18%), Positives = 122/307 (39%), Gaps = 52/307 (16%)
Query: 19 LQVDSGSGSDSEPGKGKGRNTGKSQTLGSKSTTNEKKREKRRKKKEQQQS------EANE 72
L ++ +G + + K K Q L +K+T K + EQQ+ E NE
Sbjct: 995 LHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNE 1054
Query: 73 LRNLAFKKIPQKSSHAVCNAQHDLPLSNPVQKDSREENWQEWRQRDEQLTSEMFEADLEK 132
L+ + I +K K +EN + + E+L + +L+K
Sbjct: 1055 LQQMLESVIAEKEQ----------------LKTDLKENIEMTIENQEEL--RLLGDELKK 1096
Query: 133 ALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKRKNHQGKDRPLTVSLKDFHSEDHISK 192
+ E K+ + T + + +K K K+ Q + +
Sbjct: 1097 QQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQ------------------LQE 1138
Query: 193 KTEEVVLKDGRIERLKLELERKDAEIQKLKNVITQWEAKYKEVKARNAQLLKMLQEG--E 250
K ++++ ++ E+++K EI+ LKN + E + ++ +L + L E E
Sbjct: 1139 KQQQLL----NVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEE 1194
Query: 251 MKD---KAEILLQVDES-QSIKNELTIQVTSLHAALEQERSKVKVLQAELAKYQGGRKGK 306
+K + ++L ++ +S ++ ++ L + + A Q + ++K+ L ++Q
Sbjct: 1195 VKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDEL 1254
Query: 307 RNSESDQ 313
R S S++
Sbjct: 1255 RRSVSEK 1261
Score = 32.3 bits (72), Expect = 0.56
Identities = 67/283 (23%), Positives = 114/283 (40%), Gaps = 57/283 (20%)
Query: 47 SKSTTNEKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDLPLSNPVQKDS 106
++ST E++ K+ EQ E FK + AQ NP +D+
Sbjct: 2312 NESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQ-----VNPTTQDN 2366
Query: 107 REENWQEWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDK 166
+ + R QLT+E +LE +L +K E HK +SK++ K +
Sbjct: 2367 KNPHVTS---RATQLTTEKIR-ELENSLHEAK-ESAMHK-----------ESKII--KMQ 2408
Query: 167 RKNHQGKDRPLTVSLKDFHSEDHISKKTEEV-VLKDG----------RIERLKLELERKD 215
++ D + K S + K E + VL+D IE LK++L + D
Sbjct: 2409 KELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKID 2468
Query: 216 AEIQKLKNVITQWEAKYKEVKAR---NAQLLKMLQEG-----EMKDKAEILLQVDESQS- 266
E K+KN ++E + KA +++++L+E + +D + I D S
Sbjct: 2469 LE--KMKNA-KEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSN 2525
Query: 267 -----------IKNELTIQVTSLHAALEQERSKVKVLQAELAK 298
++N + + S H LE+E SK+K +L K
Sbjct: 2526 KPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIK 2568
Score = 30.4 bits (67), Expect = 2.1
Identities = 51/187 (27%), Positives = 84/187 (44%), Gaps = 31/187 (16%)
Query: 48 KSTTNEKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDLPLSNPVQKDSR 107
KS +K+ + +KKE Q E N++ KKI N L Q +++
Sbjct: 1963 KSKDELQKKIQELQKKELQLLRVKEDVNMSHKKI---------NEMEQL----KKQFEAQ 2009
Query: 108 EENWQEWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQ----SKVMNK 163
+ Q R + QLT ++ E+ LE+ +++K E +E ++ E + Q + M
Sbjct: 2010 NLSMQSVRMDNFQLTKKLHES-LEEIRIVAK-ERDELRRIKESLKMERDQFIATLREMIA 2067
Query: 164 KDKRKNHQGKDRPLTVSLKDFHSEDHISKKTEEV--VLK-----DGRIE---RLKLELER 213
+D R+NHQ K +S H + + +K + +LK D E RL L+LE
Sbjct: 2068 RD-RQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLE- 2125
Query: 214 KDAEIQK 220
K+ E QK
Sbjct: 2126 KEIEFQK 2132
>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
Length = 1460
Score = 50.1 bits (118), Expect = 3e-06
Identities = 66/268 (24%), Positives = 126/268 (47%), Gaps = 33/268 (12%)
Query: 49 STTNEKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDLPLSNPVQKDSRE 108
S+ +K +E ++K++ Q Q ++ + ++ QKS H V +H+L + + ++ R+
Sbjct: 790 SSLQKKIQEAQQKEEAQLQKCLGQVEH----RVHQKSYH-VAGYEHEL---SSLLREKRQ 841
Query: 109 ENWQEWRQRDEQLTSE----------MFEADLEK--ALLLSKL--EYEEHKKEYEDAENT 154
E E +R +++ E +EA+ K A LL L E E ++ +E T
Sbjct: 842 EVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELET 901
Query: 155 STQSKVMNKKDKRKNHQGKDRPLTVSLKDFHSEDHISKKTEEVVLKDGRIERLKLELERK 214
Q + +D R+ H+ ++R L+D + + + ++V R+ L+++ E
Sbjct: 902 VRQEQHKRLEDLRRRHREQER----KLQDLELD--LETRAKDV---KARLALLEVQEETA 952
Query: 215 DAEIQKLKNVITQWEAKYKEVKARNAQLLKMLQEGE--MKDKAEILLQVDESQSIKNELT 272
E Q+L +V Q K +E A + QL + +E ++ ++ +DE Q+ K +L
Sbjct: 953 RREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLE 1012
Query: 273 IQVTSLHAALEQERSKVKVLQAELAKYQ 300
QV L A +Q + L+AE K Q
Sbjct: 1013 SQVDLLQAQSQQLQKHFSSLEAEAQKKQ 1040
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 50.1 bits (118), Expect = 3e-06
Identities = 50/234 (21%), Positives = 104/234 (44%), Gaps = 14/234 (5%)
Query: 63 KEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDLPLSNPVQKDSREENWQEWRQRDEQLT 122
K + S+ LR+L +KI Q+ + Q+D ++ ++ EQL
Sbjct: 527 KAKNTSQETMLRDLQ-EKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLN 585
Query: 123 SEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKRKNHQGKDRPLTVSLK 182
++ + + E LLS LE + KKEYE+ + T ++++ Q + + K
Sbjct: 586 DKLSKTEKESKALLSALELK--KKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSK 643
Query: 183 DFHSEDHISKKTEEVVLKDGRIERLKLELERKDAEIQKLKNVITQWEAKYKEVKARNAQL 242
H E + + + + R+ L+++ E EI+ L NV+ ++K EV+ +
Sbjct: 644 INHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVL---DSKSVEVETQKLAY 700
Query: 243 LKMLQEGEMKDKAEILLQVDESQSIKNELTIQVTSLHAALEQERSKVKVLQAEL 296
+++ Q+ E D+ + I+N + ++ + L +E K+++L E+
Sbjct: 701 MELQQKAEFSDQ-------KHQKEIEN-MCLKTSQLTGQVEDLEHKLQLLSNEI 746
Score = 44.7 bits (104), Expect = 1e-04
Identities = 53/263 (20%), Positives = 118/263 (44%), Gaps = 16/263 (6%)
Query: 41 KSQTLGSKSTTNEKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDLPLSN 100
K++ L + S+ + + + +E+ QS + + L+ K ++ A N + +L +
Sbjct: 2012 KTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKE 2071
Query: 101 PVQKDSR-EENWQEWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKK----EYEDAENTS 155
+R E+ E + L + + E E AL LS + E H+ E +
Sbjct: 2072 SESLQARLSESDYEKLNVSKALEAALVEKG-EFALRLSSTQEEVHQLRRGIEKLRVRIEA 2130
Query: 156 TQSKVMNKKDKRKNHQGKDRPLTVSLKDFHSEDHISKKTEEVVLKDGRIERLKLELERKD 215
+ K ++ +K K + ++ L +++ E +S++ +E+V+ D E K E+E
Sbjct: 2131 DEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDA--ENSKAEVETLK 2188
Query: 216 AEIQKLKNVITQWEAKYKEVKARNAQLLKMLQE--GEMKDKAEILLQVDESQSIKNELTI 273
+I+++ + +E +++ L K +QE G++ + ++L K + I
Sbjct: 2189 TQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEI 2248
Query: 274 QVTSLHAALEQERSKVKVLQAEL 296
Q+ E+ ++ V++LQ +L
Sbjct: 2249 QIK------EESKTAVEMLQNQL 2265
Score = 41.6 bits (96), Expect = 0.001
Identities = 57/251 (22%), Positives = 107/251 (42%), Gaps = 29/251 (11%)
Query: 37 RNTGKSQTLGSKSTTNEKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDL 96
R T + +K T E+K +K + Q+ A R +KI +K Q +L
Sbjct: 345 RTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEF----QEEL 400
Query: 97 PLSNPVQKDSREENWQEWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTST 156
Q+ S + QE Q +LT E+ +A +L ++L+ K+ +
Sbjct: 401 SR----QQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEF 456
Query: 157 QSKVMNKKDKRKNHQGKDRPLTVSLKDFHSEDHISKKTEEVVLKDGRIERLKLELERKDA 216
+ K+ + + Q K+ L S+++ E+++ K E + E+ +A
Sbjct: 457 KQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAR---------EVCHLEA 507
Query: 217 EIQKLKNVITQWEAKYKEVKARNAQLLKMLQEGEMKDKAEILLQVDESQSIKNELTIQVT 276
E++ +K + Q + +E+KA+N QE ++D E + Q + N LT++
Sbjct: 508 ELKNIKQCLNQSQNFAEEMKAKNTS-----QETMLRDLQEKINQQE------NSLTLEKL 556
Query: 277 SLHAA-LEQER 286
L A LE++R
Sbjct: 557 KLAVADLEKQR 567
Score = 41.2 bits (95), Expect = 0.001
Identities = 62/288 (21%), Positives = 117/288 (40%), Gaps = 31/288 (10%)
Query: 53 EKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCN----AQHDLPLSN-PVQKDSR 107
E +EK K+ E+++ E++ L KK Q A N A+H S Q++
Sbjct: 165 EDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKT 224
Query: 108 EENWQEWRQRD---EQLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTST-----QSK 159
+ QR ++ F + E S L+ + +N+S+ Q K
Sbjct: 225 PSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLK 284
Query: 160 VMNKKDKRKNH------QGKDRPLTVSLKDFHS-EDHISKKTEEVVLKDGRIERLKLELE 212
N++ + K + QG ++ + + F + + K E++ K+ + + + EL
Sbjct: 285 AQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELV 344
Query: 213 RKDAEIQKLKNVITQWEAKYKEV------KARNAQLLKMLQEGEMKDKA-----EILLQV 261
R A+ + T E K K++ + +NA+ + E ++K+K E+ Q
Sbjct: 345 RTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQ 404
Query: 262 DESQSIKNELTIQVTSLHAALEQERSKVKVLQAELAKYQGGRKGKRNS 309
Q++ E L L+Q ++ VLQAEL K ++ N+
Sbjct: 405 RSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENN 452
Score = 38.9 bits (89), Expect = 0.006
Identities = 60/297 (20%), Positives = 116/297 (39%), Gaps = 30/297 (10%)
Query: 39 TGKSQTLGSKSTTNEKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDLPL 98
TG+ + L K + + + + +E LR+L + K + V N H L
Sbjct: 729 TGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDL----LKSKDASLVTNEDHQRSL 784
Query: 99 SNPVQKDSREENWQEWRQRDEQLTSEMFEADLE-------KALLLSKLEYEEHKKEYEDA 151
Q+ + ++ + SE E LE A+L ++++ E E +
Sbjct: 785 LAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQ 844
Query: 152 ENTSTQSKVMNKKDKRKNHQGKDRPLTVSLKDFH------SEDHISKKTEEVVLKDGRIE 205
N+ Q + ++ +G+ + + H + ISK E+ +
Sbjct: 845 MNSDLQKQC----EELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVA 900
Query: 206 RLKLELERKDAEIQKLKNVITQWEAKYKEVKARNAQL------LKMLQEGEMKDKAEILL 259
LE K+ E+Q L + + +A+ +E+K N L L++L E +K E+
Sbjct: 901 ETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSS 960
Query: 260 QVDESQSIKNELTIQ---VTSLHAALEQERSKVKVLQAELAKYQGGRKGKRNSESDQ 313
+ ++ ELT + + ++A+L QE+ + A Y R+ + SDQ
Sbjct: 961 IISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQ 1017
Score = 35.4 bits (80), Expect = 0.066
Identities = 50/260 (19%), Positives = 112/260 (43%), Gaps = 22/260 (8%)
Query: 40 GKSQTLGSKSTTNEKKREKRRKKK---EQQQSEANELRNLAFKKIPQKSSHAVCNAQHDL 96
G+ T+ K+T ++ EK ++K E QSE +A ++ +K+
Sbjct: 1965 GELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQT------ 2018
Query: 97 PLSNPVQKDSREENWQEWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTST 156
LS+ V + +++ +++ + L + L K L +++ +KE E+ S
Sbjct: 2019 -LSSDVSELLKDKT--HLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESL 2075
Query: 157 QSKVMNKKDKRKNHQGKDRPLTVSLKDFHSEDHISKKTEEVVLKDGRIERLKLELERKDA 216
Q+++ ++ N V +F +S EEV IE+L++ +E +
Sbjct: 2076 QARLSESDYEKLNVSKALEAALVEKGEFALR--LSSTQEEVHQLRRGIEKLRVRIEADEK 2133
Query: 217 EIQKLKNVITQWEAKYKEVKARNAQLLKMLQEGEMKDKAEILLQVDESQSIKNELTIQVT 276
+ + + + E + +K + L + LQ E +++ ++L + S++ +V
Sbjct: 2134 KQLHIAEKLKERERENDSLKDKVENLERELQMSE-ENQELVILDAENSKA-------EVE 2185
Query: 277 SLHAALEQERSKVKVLQAEL 296
+L +E+ +KV + +L
Sbjct: 2186 TLKTQIEEMARSLKVFELDL 2205
Score = 35.4 bits (80), Expect = 0.066
Identities = 52/217 (23%), Positives = 97/217 (44%), Gaps = 37/217 (17%)
Query: 106 SREENWQEWRQRDEQLTSEM--FEADLEKALLLSKLEYEEHKKEYEDA-ENTSTQSKVMN 162
S +EN Q++++ SE+ + E L + E + K++ A E TQ K +N
Sbjct: 2392 SEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELN 2451
Query: 163 KK-----DKRKNHQGKDRPLTVSLKDFHSEDHI------SKKTEEVVLKDG------RIE 205
++ + ++ + K++ L+ ++ E K +VL+ +E
Sbjct: 2452 ERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVE 2511
Query: 206 RLKLELERKDAEIQKLKNVI----------TQWEAKYKEVKARNAQLLKMLQEGEMKDKA 255
K +LE+KD EI +LKN I +Q E +++ K +N +L + E E K
Sbjct: 2512 DGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQK--- 2568
Query: 256 EILLQVDESQSIKNELTIQV-TSLHAALEQERSKVKV 291
+QV +S++ + T++V S + LE E K+
Sbjct: 2569 ---IQVLQSKNASLQDTLEVLQSSYKNLENELELTKM 2602
Score = 34.3 bits (77), Expect = 0.15
Identities = 56/286 (19%), Positives = 117/286 (40%), Gaps = 37/286 (12%)
Query: 35 KGRNTGKSQTLGSKSTTNE--KKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNA 92
+G + K+ + +S+ N ++ E ++K E++ E + L+N + S +
Sbjct: 2487 QGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEG 2546
Query: 93 QHDLPLSNPVQKDSREENWQEWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYEDAE 152
+H L W++++ +L + E + + +L SK + E +
Sbjct: 2547 EHQL-----------------WKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSS 2589
Query: 153 NTSTQSKVMNKKDKRKNHQGKDRPLTVSLKDFHSEDH-ISKKTEEVVLKDGRIERLKLEL 211
+ ++++ K + + K +T + E H +++KT E+ E L E
Sbjct: 2590 YKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQ------EELSGEK 2643
Query: 212 ERKDAEIQKLKNVITQWEAKYKEVKARNAQLLKMLQEGEMKDKAEILLQVDESQSIKNEL 271
R E+Q L I + + KE+ N++L K L + KD QV++ ++ E+
Sbjct: 2644 NRLAGELQLLLEEIKSSKDQLKELTLENSELKKSL-DCMHKD------QVEKEGKVREEI 2696
Query: 272 TIQVTSLHAALEQERSKV----KVLQAELAKYQGGRKGKRNSESDQ 313
LH A ++ ++ + K + E+ Y+ K S Q
Sbjct: 2697 AEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQ 2742
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 49.7 bits (117), Expect = 3e-06
Identities = 63/284 (22%), Positives = 123/284 (43%), Gaps = 29/284 (10%)
Query: 53 EKKREKRRKKKEQQQSEANELRNLAFKKIPQKS----------SHAVCNAQHDLPLSNPV 102
E+++ +RR++ +Q Q E + L+ ++ Q+ +H L +
Sbjct: 836 EEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPAL 895
Query: 103 QKDSREENWQEWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMN 162
Q+ R+E Q ++ +E+L E E + + +Y E ++ ++ E + +
Sbjct: 896 QEQLRKEQ-QLLQEEEEELQREEREKRRRQE---QERQYREEEQLQQEEEQLLREEREKR 951
Query: 163 KKDKRKNHQGKDRPLTVSLKDFHSEDHISKKTEEVVLKDGRIERLKLELERKDAEIQKLK 222
++ +R+ KD+ L + E+ ++ +E K E L+ E E+ E ++ K
Sbjct: 952 RRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLRE-EREK 1010
Query: 223 NVITQWEAKYK---EVKARNAQLL------KMLQEGEMKDKAEILLQVDESQSIKNELTI 273
+WE +Y+ E++ QLL + LQE E + + E LQ +E Q + E
Sbjct: 1011 RRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEE--- 1067
Query: 274 QVTSLHAALEQERSKVKVLQAELAKY--QGGRKGKRNSESDQCR 315
+ T LE++ K + LQ E + + K +R QCR
Sbjct: 1068 RETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCR 1111
Score = 39.3 bits (90), Expect = 0.005
Identities = 40/210 (19%), Positives = 88/210 (41%), Gaps = 52/210 (24%)
Query: 53 EKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDLPLSNPVQKDSREENWQ 112
E+ ++RR+++E+Q E EL Q+ + + + +++ REE +
Sbjct: 1096 EEPEKRRRQERERQCREEEEL---------QQEEEQLLREEREKRRRQELERQYREE--E 1144
Query: 113 EWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKRKNHQG 172
E +Q +EQL E E K +E +++Y + E + + + ++++ K Q
Sbjct: 1145 EVQQEEEQLLREEPE----------KRRRQELERQYREEEELQQEEEQLLREEQEKRRQE 1194
Query: 173 KDRPLTVSLKDFHSEDHISKKTEEVVLKDGRIERLKLELERKDAEIQKLKNVITQWEAKY 232
++R + EE + + R +R + E +R D + QWE +
Sbjct: 1195 RER---------------QYREEEELQRQKRKQRYRDEDQRSDLK--------WQWEPEK 1231
Query: 233 KEV--------KARNAQLLKMLQEGEMKDK 254
+ K R + + L++ +++D+
Sbjct: 1232 ENAVRDNKVYCKGRENEQFRQLEDSQLRDR 1261
Score = 39.3 bits (90), Expect = 0.005
Identities = 51/264 (19%), Positives = 113/264 (42%), Gaps = 19/264 (7%)
Query: 54 KKREKRRKKKEQQQSEANEL-RNLAFKKIPQKSSHAVCNAQHDLPLSNPVQKD----SRE 108
+++EKRR+++E+Q E EL R ++ + + Q + N V+ +
Sbjct: 1186 EEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGR 1245
Query: 109 ENWQEWRQRDEQLTSEMFEADLEKAL-LLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKR 167
EN Q + D QL + DL+ L + + E+ ++ ++ + + + + +++++
Sbjct: 1246 ENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQL-EREEQ 1304
Query: 168 KNHQGKDRPLTVSLKDFHSEDHISKKTEEVVLKDGRIERLKLELERKDAEIQKLKNVITQ 227
K + +DR + E ++ +E K E+L E E + Q+ +
Sbjct: 1305 KEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFRE 1364
Query: 228 WEAKYKEVKARNAQLLKMLQEGEMKDKAEILLQVDESQSIKNELTIQVTSLHAALEQERS 287
E +++E Q K L+E + + Q E + +K E ++ L Q+R
Sbjct: 1365 EELRHQE------QGRKFLEE-----EQRLRRQERERKFLKEEQQLRCQEREQQLRQDRD 1413
Query: 288 -KVKVLQAELAKYQGGRKGKRNSE 310
K + + +L++ + RK + +
Sbjct: 1414 RKFREEEQQLSRQERDRKFREEEQ 1437
Score = 38.9 bits (89), Expect = 0.006
Identities = 44/262 (16%), Positives = 113/262 (43%), Gaps = 24/262 (9%)
Query: 28 DSEPGKGKG-------RNTGKSQTLGSKSTTNEKKREKRRKK---KEQQQSEANELRNLA 77
+ EPG+ + R + + K E++ +RR + +++Q+ + E R
Sbjct: 130 EEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAE 189
Query: 78 FKKIPQKSSHAVCNAQHDLPLSN----PVQKDSREENWQEWRQRDEQLTSEMFEADLEKA 133
+++ H + L +++ REE Q+ R+R +++ E E + K
Sbjct: 190 EEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKR 249
Query: 134 LLL-----SKLEYEEHKKEYEDAENTSTQSKVMNKKDKRKNHQGKDRPLTVSLKDFHSED 188
+ KL+ EE +++ E E K+ ++ +R+ + + + + +
Sbjct: 250 ETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRK 309
Query: 189 HISKKTEEVVLKDGRIERLKLELERKDAEIQKLKNVITQWEAKYKEVKARNAQLLKMLQE 248
++ E+ + + ER + + ER++ ++++ + + + + ++ + R Q L+ QE
Sbjct: 310 QEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQE 369
Query: 249 GEMKDKAEILLQVDESQSIKNE 270
E +++ Q+ Q ++ E
Sbjct: 370 EERREQ-----QLRREQQLRRE 386
Score = 37.4 bits (85), Expect = 0.017
Identities = 42/241 (17%), Positives = 100/241 (41%), Gaps = 16/241 (6%)
Query: 45 LGSKSTTNEKKREKRRKKKEQQ---QSEANELRNLAFKKIPQKSSHAVCNAQHDLPLSNP 101
L + ++RE++ K+EQQ Q +LR +K ++ + + D
Sbjct: 1377 LEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQ-LSRQERDRKFREE 1435
Query: 102 VQKDSREENWQEWRQRDEQLTSEMFEADLEKALLLSKLE------YEEHKKEYEDAENTS 155
Q+ R+E +++ + ++QL E E+ LL + E E +K E+ +
Sbjct: 1436 EQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLR 1495
Query: 156 TQSKVMNKKDKRKNHQGKDRPLTVSLKDFHSEDHISK--KTEEVVLKDGRIERLKLELER 213
Q + +++ Q +R + H + K + E+ + + R ++ + + +R
Sbjct: 1496 RQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDR 1555
Query: 214 KDAEIQKLKNVITQWEAKYKE----VKARNAQLLKMLQEGEMKDKAEILLQVDESQSIKN 269
K E ++L+ + + +E + ++ + QE + + + L + + Q ++
Sbjct: 1556 KFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQ 1615
Query: 270 E 270
E
Sbjct: 1616 E 1616
Score = 35.0 bits (79), Expect = 0.087
Identities = 44/241 (18%), Positives = 102/241 (42%), Gaps = 35/241 (14%)
Query: 53 EKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDLPLSNPVQKDSREENWQ 112
E++R++ K +EQ++ +LR ++ ++ + + + L ++++ EE
Sbjct: 627 EERRQQLLKSEEQEERRQQQLR----REQQERREQRLKREEEEERLEQRLKREHEEE--- 679
Query: 113 EWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKRKNHQG 172
+R+++L E E + + + S++ + + E +E + QSKV ++ K+ +G
Sbjct: 680 ---RREQELAEE--EQEQARERIKSRIPKWQWQLE---SEADARQSKVYSRPRKQ---EG 728
Query: 173 KDRPLTVSLKDFHSEDHISKKTEEVVLKDGRIERLKLELERKDAEIQKLKNVITQWEAKY 232
+ R K E + + EE R+ E ++ ++ QW+A+
Sbjct: 729 QRRRQEQEEKRRRRESELQWQEEE-------------RAHRQQQEEEQRRDFTWQWQAEE 775
Query: 233 KEVKARNAQLLKMLQEGEMKDKAEILLQVDESQSIKNELTIQVTSLHAALEQERSKVKVL 292
K + R ++ ++++ E L+ +E Q + + Q R + K L
Sbjct: 776 KSERGRQ----RLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKEL 831
Query: 293 Q 293
Q
Sbjct: 832 Q 832
Score = 32.3 bits (72), Expect = 0.56
Identities = 45/220 (20%), Positives = 94/220 (42%), Gaps = 27/220 (12%)
Query: 53 EKKREKRRKKKEQQQSEANELRNLA-FKKI-------PQKSSHAVCNAQHDLPLSNPVQ- 103
E +R+ R +++ +Q++E +LR ++KI P++ + + D Q
Sbjct: 1720 ELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQL 1779
Query: 104 KDSREENWQEWRQRD------EQLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQ 157
+ REE ++ D EQL E E L K +EE + + E+ E Q
Sbjct: 1780 RQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQ 1839
Query: 158 SKVMN-KKDKRKNHQGKDRPLTVSLKDFHSEDHISKKTEEVVLKDGRIERLKLELERKDA 216
+ + +++ Q K R L + E+ ++ E L++ I R + E E++
Sbjct: 1840 ERDRQYRAEEQFATQEKSRREEQEL--WQEEEQKRRQERERKLREEHIRRQQKE-EQRHR 1896
Query: 217 EIQKLKN--------VITQWEAKYKEVKARNAQLLKMLQE 248
++ ++K+ ++ ++ V R++ L + +QE
Sbjct: 1897 QVGEIKSQEGKGHGRLLEPGTHQFASVPVRSSPLYEYIQE 1936
>gi|239757009 PREDICTED: ankyrin repeat domain 20 family, member A5
[Homo sapiens]
Length = 823
Score = 48.5 bits (114), Expect = 8e-06
Identities = 63/266 (23%), Positives = 110/266 (41%), Gaps = 36/266 (13%)
Query: 49 STTNEKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHD-LPLSNPVQKDSR 107
++ E++R +R +KK+ Q E N ++ + H+ +A D L + K
Sbjct: 367 ASEEEQQRRERSEKKQPQVIEGNNTYKSEKIQLSENICHSTFSAAADRLTQQRKIGKTYP 426
Query: 108 EENWQEWRQRDEQLTSEMFEADLEKALLLSKLEYEE-------HKKEYEDAENTST-QSK 159
++ ++ ++ ++ T + + +L K EE +KKE E + T QS
Sbjct: 427 QQFPKKLKEEHDRCTLKQENEEKTNVNMLHKKNREELERKEKQYKKEVEAKQLEPTVQSL 486
Query: 160 VMNKKDKRKNHQGKDRPLTVSLKDFHSEDHISKKTEEVVLKDGRIERLKLELERKDAEIQ 219
M K R +DFH+ + + +E + LK ++ EI
Sbjct: 487 EMKPKTARNTPN----------QDFHNHEEVKDLMDENCI-------LKTDIAILRQEIC 529
Query: 220 KLKNVITQWEAKY----KEVKARNAQLLKMLQ-EGEMKDKAEILLQVDESQSIKNELTIQ 274
+KN + E KY K K NA L K ++ EM K Q + N+L +
Sbjct: 530 TMKNDNLEKENKYLKDIKIAKETNAALEKCIKLNEEMITKTAFWYQQE-----LNDLKAE 584
Query: 275 VTSLHAALEQERSKVKVLQAELAKYQ 300
T L++ L +E+ K L+AE+ YQ
Sbjct: 585 NTRLNSELLKEKESKKKLEAEIESYQ 610
Score = 28.5 bits (62), Expect = 8.1
Identities = 33/151 (21%), Positives = 63/151 (41%), Gaps = 30/151 (19%)
Query: 124 EMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKRKNHQGKDRPLTVSL-- 181
E+ + E L S+L E+ K+ +AE S QS++ K + +R L ++L
Sbjct: 577 ELNDLKAENTRLNSELLKEKESKKKLEAEIESYQSRLAAAISKHSENVKTERNLKLALER 636
Query: 182 -KDFHSEDHISKKTEEV-------------------VLKDGRIERLKLELERKDAEIQKL 221
+D + +S E+ LKD + + + L +K ++ +
Sbjct: 637 TQDISEQVKMSSDISEIEDKNXFLTEQLSKMQIKFNTLKD-KFRKTRDTLRKKSLALETV 695
Query: 222 KNVITQWEAKYKEVKARNAQLLKMLQEGEMK 252
+N ++Q + + KE+K +M Q E K
Sbjct: 696 QNDLSQTQQQIKEMK-------EMYQSAEAK 719
>gi|239751523 PREDICTED: ankyrin repeat domain 20 family, member A5
[Homo sapiens]
Length = 823
Score = 48.5 bits (114), Expect = 8e-06
Identities = 63/266 (23%), Positives = 110/266 (41%), Gaps = 36/266 (13%)
Query: 49 STTNEKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHD-LPLSNPVQKDSR 107
++ E++R +R +KK+ Q E N ++ + H+ +A D L + K
Sbjct: 367 ASEEEQQRRERSEKKQPQVIEGNNTYKSEKIQLSENICHSTFSAAADRLTQQRKIGKTYP 426
Query: 108 EENWQEWRQRDEQLTSEMFEADLEKALLLSKLEYEE-------HKKEYEDAENTST-QSK 159
++ ++ ++ ++ T + + +L K EE +KKE E + T QS
Sbjct: 427 QQFPKKLKEEHDRCTLKQENEEKTNVNMLHKKNREELERKEKQYKKEVEAKQLEPTVQSL 486
Query: 160 VMNKKDKRKNHQGKDRPLTVSLKDFHSEDHISKKTEEVVLKDGRIERLKLELERKDAEIQ 219
M K R +DFH+ + + +E + LK ++ EI
Sbjct: 487 EMKPKTARNTPN----------QDFHNHEEVKDLMDENCI-------LKTDIAILRQEIC 529
Query: 220 KLKNVITQWEAKY----KEVKARNAQLLKMLQ-EGEMKDKAEILLQVDESQSIKNELTIQ 274
+KN + E KY K K NA L K ++ EM K Q + N+L +
Sbjct: 530 TMKNDNLEKENKYLKDIKIAKETNAALEKCIKLNEEMITKTAFWYQQE-----LNDLKAE 584
Query: 275 VTSLHAALEQERSKVKVLQAELAKYQ 300
T L++ L +E+ K L+AE+ YQ
Sbjct: 585 NTRLNSELLKEKESKKKLEAEIESYQ 610
Score = 28.5 bits (62), Expect = 8.1
Identities = 33/151 (21%), Positives = 63/151 (41%), Gaps = 30/151 (19%)
Query: 124 EMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKRKNHQGKDRPLTVSL-- 181
E+ + E L S+L E+ K+ +AE S QS++ K + +R L ++L
Sbjct: 577 ELNDLKAENTRLNSELLKEKESKKKLEAEIESYQSRLAAAISKHSENVKTERNLKLALER 636
Query: 182 -KDFHSEDHISKKTEEV-------------------VLKDGRIERLKLELERKDAEIQKL 221
+D + +S E+ LKD + + + L +K ++ +
Sbjct: 637 TQDISEQVKMSSDISEIEDKNXFLTEQLSKMQIKFNTLKD-KFRKTRDTLRKKSLALETV 695
Query: 222 KNVITQWEAKYKEVKARNAQLLKMLQEGEMK 252
+N ++Q + + KE+K +M Q E K
Sbjct: 696 QNDLSQTQQQIKEMK-------EMYQSAEAK 719
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 48.5 bits (114), Expect = 8e-06
Identities = 45/195 (23%), Positives = 87/195 (44%), Gaps = 32/195 (16%)
Query: 120 QLTSEMFEADLEKALLLSKLE-YEEHKKEYEDAENTSTQSKVMNKKDKRKNHQGKDRPLT 178
QL SE+ + E A+ + +L+ + E T T++ + ++D K
Sbjct: 271 QLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTK---------- 320
Query: 179 VSLKDFHSEDHISKKTEEVVL----------------KDGRIERLKLELERKDAEIQKLK 222
L++ H+E+ +SKK + L + + R+ +EL K QKLK
Sbjct: 321 --LEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLK 378
Query: 223 NVITQWEAKYKEVKARNAQLLKMLQEGEMKDKAEILLQVDESQSIKNELTIQVTSLHAAL 282
+++ E KY+ +KA QL + +E E + ++ ++++ S E Q+ H L
Sbjct: 379 EELSEVETKYQHLKAEFKQLQQQREEKE-QHGLQLQSEINQLHSKLLETERQLGEAHGRL 437
Query: 283 EQER--SKVKVLQAE 295
+++R S K++ E
Sbjct: 438 KEQRQLSSEKLMDKE 452
Score = 47.0 bits (110), Expect = 2e-05
Identities = 47/201 (23%), Positives = 92/201 (45%), Gaps = 15/201 (7%)
Query: 112 QEWRQRDEQLTSEMFEADLEKALLLSKLEYEEHK--KEYEDAENTSTQSKVMNKKDK--- 166
+E R + +E+ + +EK L+++L + K K + +N+ ++ + N+K K
Sbjct: 828 EELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAI 887
Query: 167 ---RKNHQGKDRPLTVSLKDFHSEDHISKKTEEVVLKDGRIERLKLELERKDAEIQKLKN 223
K + L V +++ E KK+ E + +LKLEL ++ + +N
Sbjct: 888 LDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASH--QLKLELNSMQEQLIQAQN 945
Query: 224 VITQWEAKYKEVKARNAQLLKMLQEGEMKD----KAEILLQVDESQSIKNELTIQVTSLH 279
+ Q E + ++++ N LK E + K + E+ + V + ++N+L Q+T
Sbjct: 946 TLKQNEKEEQQLQG-NINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAA 1004
Query: 280 AALEQERSKVKVLQAELAKYQ 300
L E+ K+ VLQ K Q
Sbjct: 1005 QELAAEKEKISVLQNNYEKSQ 1025
Score = 40.4 bits (93), Expect = 0.002
Identities = 61/287 (21%), Positives = 122/287 (42%), Gaps = 60/287 (20%)
Query: 41 KSQTLGSKSTTNEKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDLPLSN 100
K Q L ++ +++RE++ + Q QSE N+L + + + L ++
Sbjct: 387 KYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHS------------KLLETERQLGEAH 434
Query: 101 PVQKDSREENWQEWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKV 160
K+ R+ + ++ +++Q+ ADL+ L LS+L EE KE + +T Q ++
Sbjct: 435 GRLKEQRQLSSEKLMDKEQQV------ADLQ--LKLSRL--EEQLKE-KVTNSTELQHQL 483
Query: 161 MNKKDKRKNHQGKDRPLTVSLKDFHSEDHISKKTEEVVLKDGRIERLK------------ 208
K + + Q + T L++ +++ + + ++ KD +I+ L+
Sbjct: 484 DKTKQQHQEQQALQQSTTAKLRE--AQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISL 541
Query: 209 LELERKD--AEIQ-----------------KLKNVITQWEAKYKEVKARNAQLLKMLQEG 249
LE ER+D A+IQ L+ +TQ K K + Q + L +
Sbjct: 542 LEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQ 601
Query: 250 EMKDKAEILLQVDESQSIKNELTIQVTSLHAALEQERSKVKVLQAEL 296
+ KA + D S++ V L++ L + + KV L ++
Sbjct: 602 VQEQKAHLRAAQDRVLSLET----SVNELNSQLNESKEKVSQLDIQI 644
Score = 40.4 bits (93), Expect = 0.002
Identities = 58/265 (21%), Positives = 107/265 (40%), Gaps = 30/265 (11%)
Query: 34 GKGRNTGKSQTLGSKSTTNEKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQ 93
G+G +Q T E+ + K K Q +S NL ++ ++ +H A
Sbjct: 556 GEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENL-HDQVQEQKAHL--RAA 612
Query: 94 HDLPLSNPVQKDSREENWQEWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYEDAEN 153
D LS + E +++ QL ++ + LLLS + ++
Sbjct: 613 QDRVLSLETSVNELNSQLNESKEKVSQLDIQI---KAKTELLLSAEAAKTAQRADLQNHL 669
Query: 154 TSTQSKVMNKKDKRKNHQGKDRPLTVSLKDFHSEDHISKKTEEVVLKDGRIERLKLELER 213
+ Q+ + +K+ + + +T L+D ++H S+ E LK+ + + L LE +
Sbjct: 670 DTAQNALQDKQQELNKITTQLDQVTAKLQD--KQEHCSQL--ESHLKEYKEKYLSLEQKT 725
Query: 214 KDAEIQKLKNVITQWEAKYKEVKARNAQLLKMLQEGEMKDKAEILLQVDESQSIKNELTI 273
++ E Q I + EA EVKA Q L+ LQ + + + +L +
Sbjct: 726 EELEGQ-----IKKLEADSLEVKASKEQALQDLQ---------------QQRQLNTDLEL 765
Query: 274 QVTSLHAALEQERSKVKVLQAELAK 298
+ T L LE E+ V + +L K
Sbjct: 766 RATELSKQLEMEKEIVSSTRLDLQK 790
>gi|96975038 coiled-coil domain containing 100 [Homo sapiens]
Length = 986
Score = 48.5 bits (114), Expect = 8e-06
Identities = 37/169 (21%), Positives = 82/169 (48%), Gaps = 13/169 (7%)
Query: 139 LEYEEHKKEYEDA-ENTSTQSKVMNKKDKRKNHQGKDRPLTVSLKDFHSEDHISKKTEEV 197
LE E K+ ED EN Q ++ + + + + +DR E + KK E
Sbjct: 655 LELEMWKEMQEDIFENQLKQKELAHMQALAEEWKKRDR---------ERESLVKKKVAEY 705
Query: 198 VLKDGRIERLKLELERKDAEIQKLKNVITQWEAKYKEVKARNAQLLKMLQEGEMKDKAEI 257
+ +G++++ ++LE+++ Q+L +V ++ + + KE+++ + L+ LQ+ + K +
Sbjct: 706 TILEGKLQKTLIDLEKRE---QQLASVESELQREKKELQSERQRNLQELQDSIRRAKEDC 762
Query: 258 LLQVDESQSIKNELTIQVTSLHAALEQERSKVKVLQAELAKYQGGRKGK 306
+ QV+ + +L L L +K K+L+ E +++ + K
Sbjct: 763 IHQVELERLKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNNK 811
Score = 37.7 bits (86), Expect = 0.013
Identities = 46/206 (22%), Positives = 95/206 (46%), Gaps = 23/206 (11%)
Query: 112 QEWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKRKNHQ 171
+EW++RD + S + + E +L KL+ E + + S +S++ +K + ++ +
Sbjct: 685 EEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKREQQLASVESELQREKKELQSER 744
Query: 172 GKDRPLTVSLKDFHSEDHISKKTEEVVLKDGRIERLKLELERKDAEIQKLKNVITQWEAK 231
+ +L++ +D I + E+ + ++E +L++++ + + +L+ + E K
Sbjct: 745 QR------NLQEL--QDSIRRAKEDCI---HQVELERLKIKQLEEDKHRLQQQLNDAENK 793
Query: 232 YKEVKARNAQLLKMLQEGEMKDKAEILLQVDESQSIKNELTIQVTSLHAALEQ-ERSKVK 290
YK ++ Q + + +K EI L QS N LT++ L LE +SK+
Sbjct: 794 YKILEKEFQQF-----KDQQNNKPEIRL-----QSEINLLTLEKVELERKLESATKSKLH 843
Query: 291 VLQA-ELAKYQGGRKGKRNSESDQCR 315
Q A + R +R ES R
Sbjct: 844 YKQQWGRALKELARLKQREQESQMAR 869
Score = 37.4 bits (85), Expect = 0.017
Identities = 58/270 (21%), Positives = 109/270 (40%), Gaps = 27/270 (10%)
Query: 35 KGRNTGKSQTLGSKSTTNEKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQH 94
K + Q L + +++RE KKK + + + +K + + +
Sbjct: 673 KQKELAHMQALAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDL-EKREQQLASVES 731
Query: 95 DLPLSNPVQKDSREENWQEWRQRDEQLTSE-MFEADLEKALLLSKLEYEEHK--KEYEDA 151
+L + R+ N QE + + + + + +LE+ L + +LE ++H+ ++ DA
Sbjct: 732 ELQREKKELQSERQRNLQELQDSIRRAKEDCIHQVELER-LKIKQLEEDKHRLQQQLNDA 790
Query: 152 ENTSTQSKVMNKKDKRKNHQGKDRPLTVSLKDFHSEDHISKKTEEVVLKDGRIERLKLEL 211
EN + K++ K+ ++ Q ++P + + I+ T E K+EL
Sbjct: 791 EN---KYKILEKEFQQFKDQQNNKP------EIRLQSEINLLTLE-----------KVEL 830
Query: 212 ERKDAEIQKLK-NVITQWEAKYKEVKARNAQLLKMLQEGEMKDKAEILLQVDESQSIKNE 270
ERK K K + QW KE+ AR Q + Q +K + E L Q+ E
Sbjct: 831 ERKLESATKSKLHYKQQWGRALKEL-ARLKQREQESQMARLKKQQEELEQMRLRYLAAEE 889
Query: 271 LTIQVTSLHAALEQERSKVKVLQAELAKYQ 300
T L+ ++ Q E +YQ
Sbjct: 890 KDTVKTERQELLDIRNELNRLRQQEQKQYQ 919
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 47.4 bits (111), Expect = 2e-05
Identities = 57/258 (22%), Positives = 113/258 (43%), Gaps = 26/258 (10%)
Query: 20 QVDSGSGSDSEPGKGKGRNTGKSQTLGSKSTTN--EKKREKRRKKKEQQQSEANELRNLA 77
QV+S S SDSE K + + + L K T + E EK+ K KE ++ + R ++
Sbjct: 1281 QVNSESDSDSEESK---KPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVS 1337
Query: 78 FKKIPQKS------SHAVCNAQHDL-PLSNPVQKDSREENWQEWRQRDEQLTSEMFEADL 130
+ S V ++ + P + +K EEN + ++Q+ ++ ++ E
Sbjct: 1338 SEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSS 1397
Query: 131 EKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKRKNHQGKDRPLTVSLKDFHSEDHI 190
+ S E EE +KE E+ E + + ++ D K+ GK R ++ +D +
Sbjct: 1398 SENK--SNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKS-PGKGRK---KIRKILKDDKL 1451
Query: 191 SKKTEEVVLKDGRIERLKLELERKDAEIQKLKNVITQWEAKYKEVKARNAQLLKMLQEGE 250
+T+ + ++ E + + ++ E +KL+ VI + ++ + L E
Sbjct: 1452 RTETQNALKEE---EERRKRIAEREREREKLREVI-----EIEDASPTKCPITTKLVLDE 1503
Query: 251 MKDKAEILLQVDESQSIK 268
++ E L+QV + IK
Sbjct: 1504 DEETKEPLVQVHRNMVIK 1521
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 47.4 bits (111), Expect = 2e-05
Identities = 57/258 (22%), Positives = 113/258 (43%), Gaps = 26/258 (10%)
Query: 20 QVDSGSGSDSEPGKGKGRNTGKSQTLGSKSTTN--EKKREKRRKKKEQQQSEANELRNLA 77
QV+S S SDSE K + + + L K T + E EK+ K KE ++ + R ++
Sbjct: 1319 QVNSESDSDSEESK---KPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVS 1375
Query: 78 FKKIPQKS------SHAVCNAQHDL-PLSNPVQKDSREENWQEWRQRDEQLTSEMFEADL 130
+ S V ++ + P + +K EEN + ++Q+ ++ ++ E
Sbjct: 1376 SEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSS 1435
Query: 131 EKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKRKNHQGKDRPLTVSLKDFHSEDHI 190
+ S E EE +KE E+ E + + ++ D K+ GK R ++ +D +
Sbjct: 1436 SENK--SNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKS-PGKGRK---KIRKILKDDKL 1489
Query: 191 SKKTEEVVLKDGRIERLKLELERKDAEIQKLKNVITQWEAKYKEVKARNAQLLKMLQEGE 250
+T+ + ++ E + + ++ E +KL+ VI + ++ + L E
Sbjct: 1490 RTETQNALKEE---EERRKRIAEREREREKLREVI-----EIEDASPTKCPITTKLVLDE 1541
Query: 251 MKDKAEILLQVDESQSIK 268
++ E L+QV + IK
Sbjct: 1542 DEETKEPLVQVHRNMVIK 1559
>gi|154354990 ankyrin repeat domain 26 [Homo sapiens]
Length = 1710
Score = 47.4 bits (111), Expect = 2e-05
Identities = 60/269 (22%), Positives = 121/269 (44%), Gaps = 28/269 (10%)
Query: 50 TTNEKKREKRRKKKEQQQSEANELRN-LAFKKIPQKSSHAVCNAQHDLPLSNPVQKDSR- 107
T KK E + +++ SE E+++ L +K+ + +C+ + L ++++
Sbjct: 750 TVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERE--LCSLRFSLNQEEEKRRNADT 807
Query: 108 --EENWQEWRQRDEQLTSEM-FEADLEKALLLSKLEYEEHKKEYEDA--ENTSTQSKVMN 162
E+ ++ R+++EQ E+ + LE +L ++E K E Q ++
Sbjct: 808 LYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR 867
Query: 163 KKDKRK-------NHQGKDRPLTVSLKDFHSEDHISKKTEEVVLKDGRIERLKLELERKD 215
+++ R NH K + + ++ K +SE+ S + E+ + + L+ E+
Sbjct: 868 EQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDL--SHKNSMLQEEIAMLR 925
Query: 216 AEIQKLKNVITQWEAK----YKEVKARNAQLLKMLQEGEMKDKAEILLQ-VDESQSIKNE 270
EI +KN + E K K VK +N L K +++ E E L Q + + +
Sbjct: 926 LEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNE-----ETLTQTISQYNGRLSV 980
Query: 271 LTIQVTSLHAALEQERSKVKVLQAELAKY 299
LT + L++ LE E+ + L+AE+ Y
Sbjct: 981 LTAENAMLNSKLENEKQSKERLEAEVESY 1009
Score = 37.0 bits (84), Expect = 0.023
Identities = 57/258 (22%), Positives = 107/258 (41%), Gaps = 18/258 (6%)
Query: 52 NEKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDLPLSNPVQKDSREENW 111
+EK+ ++ ++ SE N L+ ++ +K+ V Q L++ ++K S E
Sbjct: 1182 SEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEAS 1241
Query: 112 QEWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKRKNHQ 171
E R ++ E DL+K L + + +E + + +A + K+ + K K +
Sbjct: 1242 LEVTSR-YRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCA--EKMQDHKQKLEKDN 1298
Query: 172 GKDRPLTVSLKDFHSEDHISKKTEEVVLKDGRIERLKLELERKDA-----EIQKLKNVIT 226
K + +TV K + + K L + E+LK +E K + + + KNV
Sbjct: 1299 AKLK-VTVK-KQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVEL 1356
Query: 227 QWE-AKYKEVKARNAQLLKMLQEGEMKDKAEILLQVDESQSIKNELTIQVTSLHAALEQE 285
+ E +K + + L + GE ++ E N+L ++ L A LE
Sbjct: 1357 EREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETA 1416
Query: 286 RSKV-------KVLQAEL 296
SK ++LQ EL
Sbjct: 1417 GSKCLHLDTKNQILQEEL 1434
Score = 36.6 bits (83), Expect = 0.030
Identities = 54/269 (20%), Positives = 105/269 (39%), Gaps = 19/269 (7%)
Query: 35 KGRNTGKSQTLGSKSTTNEKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQH 94
K + +Q + ++ + EK K E + L I ++
Sbjct: 885 KQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFE 944
Query: 95 DLPLSNPVQKDSREENWQEWRQRDEQLTSEMFEAD-------LEKALLLSKLEYEEHKKE 147
DL + K+ E+ + +Q +E LT + + + E A+L SKLE E+ KE
Sbjct: 945 DLK----IVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKE 1000
Query: 148 YEDAENTSTQSKVMNKKDKRKNHQGKDRPLTVSLKDFHSEDHISKKTEEVVLKDGRIERL 207
+AE S S++ R + R L ++ + + D S+ +++ + + L
Sbjct: 1001 RLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQ--RARDECSRLQDKM---NFDVSNL 1055
Query: 208 KLELERKDAEIQKLKNVITQWEAKYKEVKARNAQLLKML-QEGEMKDKAEILLQVDESQS 266
K E ++ K ++ + E ++ R+A K L E KD ++ Q+ E +
Sbjct: 1056 KDNNEILSQQLFKTESKLNSLEIEFHH--TRDALREKTLGLERVQKDLSQTQCQMKEMEQ 1113
Query: 267 IKNELTIQVTSLHAALEQERSKVKVLQAE 295
++V E ++ LQ+E
Sbjct: 1114 KYQNEQVKVNKYIGKQESVEERLSQLQSE 1142
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 46.6 bits (109), Expect = 3e-05
Identities = 59/260 (22%), Positives = 112/260 (43%), Gaps = 33/260 (12%)
Query: 41 KSQTLGSKSTTNEKKREKRRKKKEQQQSE---ANELRNLAFKKIPQKSSHAVCNAQHDLP 97
K+Q K EK RE +K +E Q + A +L K ++ + + Q+
Sbjct: 857 KTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAESEQLARGLLEEQY-FE 915
Query: 98 LSNPVQKDSREENWQEWRQRDEQLT-----SEMFEADLEKALLLSKLEYEEHKKEYEDAE 152
L+ +K + N QE +D ++ + M D+E L E E K+ E+
Sbjct: 916 LTQESKK-AASRNRQEITDKDHTVSRLEEANSMLTKDIE-ILRRENEELTEKMKKAEEEY 973
Query: 153 NTSTQSKVMNKKDKRKNHQGKDRPLTVSLKDFHSEDHISKKTEEVVLKDGRIERLKL--- 209
+ ++ N K + + +R L ++K E + KD +I+R K
Sbjct: 974 KLEKEEEISNLKAAFEKNINTERTLKTQA--------VNKLAEIMNRKDFKIDRKKANTQ 1025
Query: 210 ELERKDAEIQKLKNVITQWEAKYKEVKARNAQLLKMLQEGEMKDKAEILLQVDESQSIKN 269
+L +K+ E +KL+ + Q K+ ++ ++ + L +Q Q+ E + +N
Sbjct: 1026 DLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQA-----------QLVEECAHRN 1074
Query: 270 ELTIQVTSLHAALEQERSKV 289
EL +Q+ S + +EQ R+K+
Sbjct: 1075 ELQMQLASKESDIEQLRAKL 1094
Score = 38.1 bits (87), Expect = 0.010
Identities = 44/222 (19%), Positives = 98/222 (44%), Gaps = 22/222 (9%)
Query: 98 LSNPVQ-KDSREENWQEWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTST 156
L N +Q KD E+ + + +++ E+ E ++ L S + E +K
Sbjct: 439 LHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEY 498
Query: 157 QSKVMNKKDKRKNHQGKDRPLTVSLKDFHSEDHISKKTEEVVLKDGRIERLKLELERKDA 216
Q K + +KR+N + + L L+D + K ++ L + ++ +L+ +LE +
Sbjct: 499 QRKAEQENEKRRNVENEVSTLKDQLED------LKKVSQNSQLANEKLSQLQKQLEEAND 552
Query: 217 EIQ--------------KLKNVITQWEAKYKEVKARNAQLLKMLQEGEMKDKAEILLQVD 262
++ ++ I+Q E+ +E++ RN ++L+ + KD ++ ++
Sbjct: 553 LLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERN-RILENSKSQTDKDYYQLQAILE 611
Query: 263 ESQSIKNELTIQVTSLHAALEQERSKVKVLQAELAKYQGGRK 304
+ + + + L A + + +VK L+ L K +G RK
Sbjct: 612 AERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERK 653
Score = 34.3 bits (77), Expect = 0.15
Identities = 50/239 (20%), Positives = 98/239 (41%), Gaps = 22/239 (9%)
Query: 53 EKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDLPLSNPVQKDSREENWQ 112
E++ EKRR + + + ++L +L KK+ Q S A + LS +QK E N
Sbjct: 503 EQENEKRRNVENEVSTLKDQLEDL--KKVSQNSQLA------NEKLSQ-LQKQLEEANDL 553
Query: 113 EWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKRKNHQG 172
+ D + ++ K++ + E +E ++ SK KD +
Sbjct: 554 LRTESDTAVRLRKSHTEMSKSIS----QLESLNRELQERNRILENSKSQTDKD----YYQ 605
Query: 173 KDRPLTVSLKDF-HSEDHISKKTEEVVLKDGRIERLKLELERKDAEIQKLKNVITQWEAK 231
L +D H + I + ++ LK LE+ + E ++ ++++ E +
Sbjct: 606 LQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEKE 665
Query: 232 YKEVKARNAQLLKMLQ---EGEMKD-KAEILLQVDESQSIKNELTIQVTSLHAALEQER 286
++ LK LQ E E+ + K D+ QSI+ ++ + + L++ER
Sbjct: 666 KNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKEER 724
>gi|109134347 NY-REN-58 antigen [Homo sapiens]
Length = 701
Score = 46.6 bits (109), Expect = 3e-05
Identities = 47/221 (21%), Positives = 111/221 (50%), Gaps = 41/221 (18%)
Query: 127 EADLEKALLLSKLEYEEHKKEYED--AENTSTQSKVMNKKDKRKN----HQGKDRPLTVS 180
+++ +K L+ +L E HK Y+ AE+T Q++ + +++ K+ Q + L +
Sbjct: 28 QSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLL 87
Query: 181 LKDFHSEDHISKKTEEV------VLKDGRIERLKLELERK------------DAEIQKLK 222
L++ E + +KT+++ +L ++E L+ +++++ D E++K +
Sbjct: 88 LEELRGE--LVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYR 145
Query: 223 NVITQWEAKYKEVKA----RNAQLLKMLQEGEMKDKAEILLQVDESQSIKNE-LTIQVTS 277
V + ++ +K+ + + ++L EG++K ++EI ++ + ++N+ L + +T
Sbjct: 146 AVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVDLTK 205
Query: 278 LHAALEQER-------SKVKVLQAELAKYQGGRKGKRNSES 311
+EQ K+K L+AE+A+ + K NSE+
Sbjct: 206 DSKRVEQLAREKVYLCQKLKGLEAEVAEL---KAEKENSEA 243
Score = 41.6 bits (96), Expect = 0.001
Identities = 56/284 (19%), Positives = 119/284 (41%), Gaps = 35/284 (12%)
Query: 46 GSKSTTNEKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDLPLSNPVQKD 105
G ++ E K EK + + + ++ ++R LA + +S A + + ++ +
Sbjct: 226 GLEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSAN-------LRAE 278
Query: 106 SREENWQEWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYE-------DAENTSTQS 158
E+ Q +++ L +++ +A+ E L SK++ +H + E A S
Sbjct: 279 RLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELE 338
Query: 159 KVMNKKDKRKNHQGKDRPLTVSLKDFHSEDHISKKTEEV----VLKDGRIERL------K 208
+ NK + D + + + H + K E + K+ ++L K
Sbjct: 339 RERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEK 398
Query: 209 LELERKDAEIQKLKNVITQWEAKYKEVKARNAQLLKMLQEGEMKDKAEILLQVDESQSIK 268
LELE + A+++K+K W K+ + +M +E K E QS++
Sbjct: 399 LELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRK----------ELQSVR 448
Query: 269 NELTIQVTSLHAALEQERSKVKVLQAELAKYQGGRKGKRNSESD 312
+L Q+ ++ A E+E+++ L+ +++ Q SE+D
Sbjct: 449 LKLQQQIVTIENA-EKEKNENSDLKQQISSLQIQVTSLAQSEND 491
>gi|109134355 NY-REN-58 antigen [Homo sapiens]
Length = 701
Score = 46.6 bits (109), Expect = 3e-05
Identities = 47/221 (21%), Positives = 111/221 (50%), Gaps = 41/221 (18%)
Query: 127 EADLEKALLLSKLEYEEHKKEYED--AENTSTQSKVMNKKDKRKN----HQGKDRPLTVS 180
+++ +K L+ +L E HK Y+ AE+T Q++ + +++ K+ Q + L +
Sbjct: 28 QSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLL 87
Query: 181 LKDFHSEDHISKKTEEV------VLKDGRIERLKLELERK------------DAEIQKLK 222
L++ E + +KT+++ +L ++E L+ +++++ D E++K +
Sbjct: 88 LEELRGE--LVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYR 145
Query: 223 NVITQWEAKYKEVKA----RNAQLLKMLQEGEMKDKAEILLQVDESQSIKNE-LTIQVTS 277
V + ++ +K+ + + ++L EG++K ++EI ++ + ++N+ L + +T
Sbjct: 146 AVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVDLTK 205
Query: 278 LHAALEQER-------SKVKVLQAELAKYQGGRKGKRNSES 311
+EQ K+K L+AE+A+ + K NSE+
Sbjct: 206 DSKRVEQLAREKVYLCQKLKGLEAEVAEL---KAEKENSEA 243
Score = 41.6 bits (96), Expect = 0.001
Identities = 56/284 (19%), Positives = 119/284 (41%), Gaps = 35/284 (12%)
Query: 46 GSKSTTNEKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDLPLSNPVQKD 105
G ++ E K EK + + + ++ ++R LA + +S A + + ++ +
Sbjct: 226 GLEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSAN-------LRAE 278
Query: 106 SREENWQEWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYE-------DAENTSTQS 158
E+ Q +++ L +++ +A+ E L SK++ +H + E A S
Sbjct: 279 RLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELE 338
Query: 159 KVMNKKDKRKNHQGKDRPLTVSLKDFHSEDHISKKTEEV----VLKDGRIERL------K 208
+ NK + D + + + H + K E + K+ ++L K
Sbjct: 339 RERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDEK 398
Query: 209 LELERKDAEIQKLKNVITQWEAKYKEVKARNAQLLKMLQEGEMKDKAEILLQVDESQSIK 268
LELE + A+++K+K W K+ + +M +E K E QS++
Sbjct: 399 LELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRK----------ELQSVR 448
Query: 269 NELTIQVTSLHAALEQERSKVKVLQAELAKYQGGRKGKRNSESD 312
+L Q+ ++ A E+E+++ L+ +++ Q SE+D
Sbjct: 449 LKLQQQIVTIENA-EKEKNENSDLKQQISSLQIQVTSLAQSEND 491
>gi|50658065 SMC4 structural maintenance of chromosomes 4-like 1
[Homo sapiens]
Length = 1288
Score = 46.6 bits (109), Expect = 3e-05
Identities = 59/267 (22%), Positives = 119/267 (44%), Gaps = 16/267 (5%)
Query: 38 NTGKSQTLGSKSTTNEKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDLP 97
N K++ K T EKK K K E+ + + +L +L ++ +K HA A+
Sbjct: 360 NEMKAKNKDVKDT--EKKLNKITKFIEENKEKFTQL-DLEDVQVREKLKHATSKAKK--- 413
Query: 98 LSNPVQKDSREENWQEWRQRDEQLTSEMFEADLEKALLLSKLEYEEHK-KEYEDAENTST 156
L +QKD +E +E++ + + + E L + E EE K KE D+ T
Sbjct: 414 LEKQLQKD--KEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQET 471
Query: 157 QSKVMNKKDKRKNHQGKDRPLTVSLKDFHSEDHISKKTEEVVLKDGRIERLKLELERKDA 216
Q K+ + K G + S+ + S+ +++ ++ L R +L +
Sbjct: 472 QGLQKEKESREKELMGFSK----SVNEARSKMDVAQSELDIYLS--RHNTAVSQLTKAKE 525
Query: 217 EIQKLKNVITQWEAKYKEVKARNAQLLKMLQEGEMKDKAEILLQVDESQSIKNELTIQVT 276
+ + + +A ++++ + Q + L+E E K+ ++ + +S+ ++L +V
Sbjct: 526 ALIAASETLKERKAAIRDIEGKLPQTEQELKEKE-KELQKLTQEETNFKSLVHDLFQKVE 584
Query: 277 SLHAALEQERSKVKVLQAELAKYQGGR 303
++L RS+ KVL A + + + GR
Sbjct: 585 EAKSSLAMNRSRGKVLDAIIQEKKSGR 611
Score = 41.6 bits (96), Expect = 0.001
Identities = 36/170 (21%), Positives = 81/170 (47%), Gaps = 13/170 (7%)
Query: 143 EHKKEYEDAENTSTQSKVMNKKDKRKNHQGKDRPLTVSLKDFHSEDHISKKT----EEVV 198
+ +K +ED + + +S +++ + K KN KD ++ E++ K T E+V
Sbjct: 340 QKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQ 399
Query: 199 LKD------GRIERLKLELERKDAEIQKLKNVITQWEAKYKEVKARNAQLLKMLQEGEMK 252
+++ + ++L+ +L++ ++++ K++ + E RN L K ++ E K
Sbjct: 400 VREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKK 459
Query: 253 DKAEILLQVDESQSIKNELTI---QVTSLHAALEQERSKVKVLQAELAKY 299
K + E+Q ++ E ++ ++ + RSK+ V Q+EL Y
Sbjct: 460 LKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIY 509
Score = 28.9 bits (63), Expect = 6.2
Identities = 32/156 (20%), Positives = 62/156 (39%), Gaps = 28/156 (17%)
Query: 146 KEYEDAENTSTQSKVMNKKDKRKNHQGKDRPLTVSLKDFHSEDHISKKTEEVVLKDGRIE 205
K+ ++ + T+++V K R + +D L + +E + T E+
Sbjct: 911 KQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELK------- 963
Query: 206 RLKLELERKDAEIQKLKNVITQWEAKYKEVKARNAQLLKMLQEGE---MKDKAEILLQVD 262
LE K AE+ K N + + ++ Q LK++QE E KD I L+++
Sbjct: 964 ----SLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLE 1019
Query: 263 ESQSIKNELTIQVTSLHAALEQERSKVKVLQAELAK 298
+ + + + SK+K E++K
Sbjct: 1020 Q--------------IDGHIAEHNSKIKYWHKEISK 1041
>gi|50658063 SMC4 structural maintenance of chromosomes 4-like 1
[Homo sapiens]
Length = 1288
Score = 46.6 bits (109), Expect = 3e-05
Identities = 59/267 (22%), Positives = 119/267 (44%), Gaps = 16/267 (5%)
Query: 38 NTGKSQTLGSKSTTNEKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDLP 97
N K++ K T EKK K K E+ + + +L +L ++ +K HA A+
Sbjct: 360 NEMKAKNKDVKDT--EKKLNKITKFIEENKEKFTQL-DLEDVQVREKLKHATSKAKK--- 413
Query: 98 LSNPVQKDSREENWQEWRQRDEQLTSEMFEADLEKALLLSKLEYEEHK-KEYEDAENTST 156
L +QKD +E +E++ + + + E L + E EE K KE D+ T
Sbjct: 414 LEKQLQKD--KEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQET 471
Query: 157 QSKVMNKKDKRKNHQGKDRPLTVSLKDFHSEDHISKKTEEVVLKDGRIERLKLELERKDA 216
Q K+ + K G + S+ + S+ +++ ++ L R +L +
Sbjct: 472 QGLQKEKESREKELMGFSK----SVNEARSKMDVAQSELDIYLS--RHNTAVSQLTKAKE 525
Query: 217 EIQKLKNVITQWEAKYKEVKARNAQLLKMLQEGEMKDKAEILLQVDESQSIKNELTIQVT 276
+ + + +A ++++ + Q + L+E E K+ ++ + +S+ ++L +V
Sbjct: 526 ALIAASETLKERKAAIRDIEGKLPQTEQELKEKE-KELQKLTQEETNFKSLVHDLFQKVE 584
Query: 277 SLHAALEQERSKVKVLQAELAKYQGGR 303
++L RS+ KVL A + + + GR
Sbjct: 585 EAKSSLAMNRSRGKVLDAIIQEKKSGR 611
Score = 41.6 bits (96), Expect = 0.001
Identities = 36/170 (21%), Positives = 81/170 (47%), Gaps = 13/170 (7%)
Query: 143 EHKKEYEDAENTSTQSKVMNKKDKRKNHQGKDRPLTVSLKDFHSEDHISKKT----EEVV 198
+ +K +ED + + +S +++ + K KN KD ++ E++ K T E+V
Sbjct: 340 QKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQ 399
Query: 199 LKD------GRIERLKLELERKDAEIQKLKNVITQWEAKYKEVKARNAQLLKMLQEGEMK 252
+++ + ++L+ +L++ ++++ K++ + E RN L K ++ E K
Sbjct: 400 VREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKK 459
Query: 253 DKAEILLQVDESQSIKNELTI---QVTSLHAALEQERSKVKVLQAELAKY 299
K + E+Q ++ E ++ ++ + RSK+ V Q+EL Y
Sbjct: 460 LKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIY 509
Score = 28.9 bits (63), Expect = 6.2
Identities = 32/156 (20%), Positives = 62/156 (39%), Gaps = 28/156 (17%)
Query: 146 KEYEDAENTSTQSKVMNKKDKRKNHQGKDRPLTVSLKDFHSEDHISKKTEEVVLKDGRIE 205
K+ ++ + T+++V K R + +D L + +E + T E+
Sbjct: 911 KQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELK------- 963
Query: 206 RLKLELERKDAEIQKLKNVITQWEAKYKEVKARNAQLLKMLQEGE---MKDKAEILLQVD 262
LE K AE+ K N + + ++ Q LK++QE E KD I L+++
Sbjct: 964 ----SLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLE 1019
Query: 263 ESQSIKNELTIQVTSLHAALEQERSKVKVLQAELAK 298
+ + + + SK+K E++K
Sbjct: 1020 Q--------------IDGHIAEHNSKIKYWHKEISK 1041
>gi|150010552 FK506 binding protein 15, 133kDa [Homo sapiens]
Length = 1219
Score = 46.6 bits (109), Expect = 3e-05
Identities = 51/241 (21%), Positives = 110/241 (45%), Gaps = 27/241 (11%)
Query: 80 KIPQKSSHAVCNAQHDLPLSNPVQKDSREENWQEWRQRDEQLTSEMFEADLEKALLLSKL 139
K+ + H+ N+ +S ++ N Q Q +E+L E+ E +++
Sbjct: 536 KVEELQKHSAGNSMLIPSMSVTMETSMIMSNIQRIIQENERLKQEILEKS-------NRI 588
Query: 140 EYEEHKKEYEDAENTSTQSKVMNKKDKRKNHQGKDRPLTVSLKDFHSEDHISKKTEEVVL 199
E E++ K E E + N +++N+ + + H+E +K TEE+
Sbjct: 589 E-EQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELAA 647
Query: 200 KDGRIERLKLEL---ERKDAEIQ-KLKNVITQWE---AKYKEVKARNAQLLKMLQEGEMK 252
++ L+L++ ++K+ E+Q +L + + + + +V+A+ ++L + ++ + K
Sbjct: 648 ATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSK 707
Query: 253 DKAEILLQVDESQSIKNELTIQVTSLHAALEQERSKVKVLQAELAKYQGGRKGKRNSESD 312
K+E + + +L ++VTS LE+E + ++V + L K RK K E
Sbjct: 708 FKSE--------KQNRKQLELKVTS----LEEELTDLRVEKESLEKNLSERKKKSAQERS 755
Query: 313 Q 313
Q
Sbjct: 756 Q 756
>gi|19924131 RAD50 homolog isoform 2 [Homo sapiens]
Length = 1173
Score = 46.2 bits (108), Expect = 4e-05
Identities = 60/263 (22%), Positives = 117/263 (44%), Gaps = 45/263 (17%)
Query: 41 KSQTLGSKSTTNEKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDLPLSN 100
K T+ SK N K + ++++ + +S NEL++ L +S
Sbjct: 699 KLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKS------------------EKLQIST 740
Query: 101 PVQKDSR-EENWQEWRQRDEQLTSEMFEADLEKALLLSKLE-YEEHKKEYEDAENTS--- 155
+Q+ + EE E + L E+ +A + + L + LE +++ K+E + +NTS
Sbjct: 741 NLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKI 800
Query: 156 TQSKVMNKKDKRKNHQGKDRPLTVSLKDFHSEDHISKKTE--EVVLKDGRIERLK----- 208
Q K+ + K+K KN G + + ++D + K+TE +V+ + E+ K
Sbjct: 801 AQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINE 860
Query: 209 -LELERKDAEIQKLKNVITQWEAKYKEVKARNAQLLKMLQEGEMKDKAEILLQVDESQSI 267
+ L R+D + QK++ +W ++ RN +L ++ +E + K +QV
Sbjct: 861 DMRLMRQDIDTQKIQE---RWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQV------ 911
Query: 268 KNELTIQVTSLHAALEQERSKVK 290
+Q+ S H LE+ +K
Sbjct: 912 -----LQMKSEHQKLEENIDNIK 929
Score = 40.0 bits (92), Expect = 0.003
Identities = 64/289 (22%), Positives = 130/289 (44%), Gaps = 50/289 (17%)
Query: 48 KSTTNEKKREKRRKKK--EQQQSEANELRNLAFKKIPQ--KSSHAVCNAQHDL-PLSNPV 102
+ T +K +E + + K +Q + +A E+R+ K Q S V + +++L PL N +
Sbjct: 57 RQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRL 116
Query: 103 QKDSREENWQEWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMN 162
++ E N + + D ++ KAL K + E+ E E+ Q
Sbjct: 117 KEI--EHNLSKIMKLDNEI----------KALDSRKKQMEKDNSELEEKMEKVFQGTDEQ 164
Query: 163 KKDKRKNHQGKDRPLTVSLKDFHSEDH--------ISKKTEEVVLKDGRIERLKLELERK 214
D NHQ R L D H E ++++ E++++ G RL+L+ +R
Sbjct: 165 LNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQG---RLQLQADRH 221
Query: 215 DAEIQK----LKNVITQWE------AKYKEVKARN-AQLLKMLQEGEMKDKAEILLQVDE 263
I+ ++++ TQ E + E + +N +L++ QEGE K +++ E
Sbjct: 222 QEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAE 281
Query: 264 SQSIK----NELTIQVTSLHAALE-------QERSKVKVLQAELAKYQG 301
+++K +E+ + T L +E ++++++K ++ EL + +G
Sbjct: 282 KETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEG 330
Score = 39.3 bits (90), Expect = 0.005
Identities = 73/318 (22%), Positives = 122/318 (38%), Gaps = 65/318 (20%)
Query: 48 KSTTNEKKREKRRKKK-----------EQQQSEANELRNLAFKKIPQKSSHAVCNAQHDL 96
K T +K+ ++ R KK E + NEL+N+ ++ + S + L
Sbjct: 282 KETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGS-----SDRIL 336
Query: 97 PLSNPVQKDSREENWQEWRQRDEQLTSEMFEADLEKALL---LSKLEYEEHKKEYEDAEN 153
L + K RE + E E L E+ EKA L L KL+ E + +
Sbjct: 337 ELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTR 396
Query: 154 TSTQSKVMNKKDK----RKNHQGKDRPLTVSLKDFHS----EDHISKKTEEVVLKDGRIE 205
T + +K DK RK LT L F + ED + K++E+ R+
Sbjct: 397 TQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLA 456
Query: 206 RLKLELERKDA-------EIQKLKNVITQWEAKYKEV---KARNAQLLKMLQEGEMKDKA 255
+L EL + E+++ + ++ +E K +V + + L ++ +E E K
Sbjct: 457 KLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQ 516
Query: 256 EILLQ-------------VDESQS----------IKNELTIQVTSLHAALEQERSKVKVL 292
+L DE+QS + EL ++ L + L K+K
Sbjct: 517 RAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKST 576
Query: 293 QAELAKYQGGRKGKRNSE 310
++EL K K KR E
Sbjct: 577 ESELKK-----KEKRRDE 589
Score = 35.8 bits (81), Expect = 0.051
Identities = 64/279 (22%), Positives = 116/279 (41%), Gaps = 46/279 (16%)
Query: 45 LGSKSTTNEKKREKRRK-KKEQQQSEANE--LRNLAFKKIPQKSSHA-----VCNAQH-- 94
L SKS + R++ K KE SE N+ + N +K Q SS+ VC +Q
Sbjct: 441 LHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFE 500
Query: 95 -DLP-LSNPVQKDSREENWQE-----WRQRDEQLTSE----------MFEADLEKALLLS 137
DL L ++K S++ + Q QLT E +F+ + E ++S
Sbjct: 501 SDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVIS 560
Query: 138 KLEYEEHKKEYEDAENTSTQSKVMNKKDKRKNHQGKDRPLTVSLKDFHSEDHISKKTEEV 197
L+ K + ST+S+ + KK+KR++ P+ S+ D
Sbjct: 561 DLQ---SKLRLAPDKLKSTESE-LKKKEKRRDEMLGLVPMRQSIID-------------- 602
Query: 198 VLKDGRIERLKLELERKDAEIQKLKNVITQWEAKYKEVKARNAQLLKMLQEGEMKDKAEI 257
LK+ I L+ +L+ + +IQ+LKN I + E + L + + ++ ++
Sbjct: 603 -LKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQM 661
Query: 258 LLQVDESQSIKNELTIQVTSLHAALEQERSKVKVLQAEL 296
L+ E + + +Q L ++Q + + Q +L
Sbjct: 662 ELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKL 700
Score = 33.9 bits (76), Expect = 0.19
Identities = 44/250 (17%), Positives = 108/250 (43%), Gaps = 23/250 (9%)
Query: 50 TTNEKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDLP-LSNPVQKDSRE 108
T E+ + + + + + +A +L+ + + Q+ + QH L +S+ ++ + +
Sbjct: 654 TIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKL 713
Query: 109 ENWQEWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKRK 168
Q+ +++ + L S E EK + + L+ + +E +T QS KD ++
Sbjct: 714 I--QDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKE 771
Query: 169 NHQGKDRPLTVSLKDFHSEDH--ISKKTEEVVLKDGRIERLKLELERKDAEIQKLKNVIT 226
PL +L+ F E I+KK + ++ +K +++ ++ ++N I
Sbjct: 772 QVS----PLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQ 827
Query: 227 QWEAKYKEVKARNAQLLKMLQEGEMKDKAEILLQVDESQSIKNELTIQVTSLHAALEQER 286
+ YK+ K E E+ +++ Q+ E + K ++ + + ++ ++
Sbjct: 828 DGKDDYKKQK-----------ETELN---KVIAQLSECEKHKEKINEDMRLMRQDIDTQK 873
Query: 287 SKVKVLQAEL 296
+ + LQ L
Sbjct: 874 IQERWLQDNL 883
>gi|19924129 RAD50 homolog isoform 1 [Homo sapiens]
Length = 1312
Score = 46.2 bits (108), Expect = 4e-05
Identities = 60/263 (22%), Positives = 117/263 (44%), Gaps = 45/263 (17%)
Query: 41 KSQTLGSKSTTNEKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDLPLSN 100
K T+ SK N K + ++++ + +S NEL++ L +S
Sbjct: 838 KLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKS------------------EKLQIST 879
Query: 101 PVQKDSR-EENWQEWRQRDEQLTSEMFEADLEKALLLSKLE-YEEHKKEYEDAENTS--- 155
+Q+ + EE E + L E+ +A + + L + LE +++ K+E + +NTS
Sbjct: 880 NLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKI 939
Query: 156 TQSKVMNKKDKRKNHQGKDRPLTVSLKDFHSEDHISKKTE--EVVLKDGRIERLK----- 208
Q K+ + K+K KN G + + ++D + K+TE +V+ + E+ K
Sbjct: 940 AQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINE 999
Query: 209 -LELERKDAEIQKLKNVITQWEAKYKEVKARNAQLLKMLQEGEMKDKAEILLQVDESQSI 267
+ L R+D + QK++ +W ++ RN +L ++ +E + K +QV
Sbjct: 1000 DMRLMRQDIDTQKIQE---RWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQV------ 1050
Query: 268 KNELTIQVTSLHAALEQERSKVK 290
+Q+ S H LE+ +K
Sbjct: 1051 -----LQMKSEHQKLEENIDNIK 1068
Score = 40.0 bits (92), Expect = 0.003
Identities = 64/289 (22%), Positives = 130/289 (44%), Gaps = 50/289 (17%)
Query: 48 KSTTNEKKREKRRKKK--EQQQSEANELRNLAFKKIPQ--KSSHAVCNAQHDL-PLSNPV 102
+ T +K +E + + K +Q + +A E+R+ K Q S V + +++L PL N +
Sbjct: 196 RQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRL 255
Query: 103 QKDSREENWQEWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMN 162
++ E N + + D ++ KAL K + E+ E E+ Q
Sbjct: 256 KEI--EHNLSKIMKLDNEI----------KALDSRKKQMEKDNSELEEKMEKVFQGTDEQ 303
Query: 163 KKDKRKNHQGKDRPLTVSLKDFHSEDH--------ISKKTEEVVLKDGRIERLKLELERK 214
D NHQ R L D H E ++++ E++++ G RL+L+ +R
Sbjct: 304 LNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQG---RLQLQADRH 360
Query: 215 DAEIQK----LKNVITQWE------AKYKEVKARN-AQLLKMLQEGEMKDKAEILLQVDE 263
I+ ++++ TQ E + E + +N +L++ QEGE K +++ E
Sbjct: 361 QEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAE 420
Query: 264 SQSIK----NELTIQVTSLHAALE-------QERSKVKVLQAELAKYQG 301
+++K +E+ + T L +E ++++++K ++ EL + +G
Sbjct: 421 KETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEG 469
Score = 39.3 bits (90), Expect = 0.005
Identities = 73/318 (22%), Positives = 122/318 (38%), Gaps = 65/318 (20%)
Query: 48 KSTTNEKKREKRRKKK-----------EQQQSEANELRNLAFKKIPQKSSHAVCNAQHDL 96
K T +K+ ++ R KK E + NEL+N+ ++ + S + L
Sbjct: 421 KETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGS-----SDRIL 475
Query: 97 PLSNPVQKDSREENWQEWRQRDEQLTSEMFEADLEKALL---LSKLEYEEHKKEYEDAEN 153
L + K RE + E E L E+ EKA L L KL+ E + +
Sbjct: 476 ELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTR 535
Query: 154 TSTQSKVMNKKDK----RKNHQGKDRPLTVSLKDFHS----EDHISKKTEEVVLKDGRIE 205
T + +K DK RK LT L F + ED + K++E+ R+
Sbjct: 536 TQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLA 595
Query: 206 RLKLELERKDA-------EIQKLKNVITQWEAKYKEV---KARNAQLLKMLQEGEMKDKA 255
+L EL + E+++ + ++ +E K +V + + L ++ +E E K
Sbjct: 596 KLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQ 655
Query: 256 EILLQ-------------VDESQS----------IKNELTIQVTSLHAALEQERSKVKVL 292
+L DE+QS + EL ++ L + L K+K
Sbjct: 656 RAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKST 715
Query: 293 QAELAKYQGGRKGKRNSE 310
++EL K K KR E
Sbjct: 716 ESELKK-----KEKRRDE 728
Score = 35.8 bits (81), Expect = 0.051
Identities = 64/279 (22%), Positives = 116/279 (41%), Gaps = 46/279 (16%)
Query: 45 LGSKSTTNEKKREKRRK-KKEQQQSEANE--LRNLAFKKIPQKSSHA-----VCNAQH-- 94
L SKS + R++ K KE SE N+ + N +K Q SS+ VC +Q
Sbjct: 580 LHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFE 639
Query: 95 -DLP-LSNPVQKDSREENWQE-----WRQRDEQLTSE----------MFEADLEKALLLS 137
DL L ++K S++ + Q QLT E +F+ + E ++S
Sbjct: 640 SDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVIS 699
Query: 138 KLEYEEHKKEYEDAENTSTQSKVMNKKDKRKNHQGKDRPLTVSLKDFHSEDHISKKTEEV 197
L+ K + ST+S+ + KK+KR++ P+ S+ D
Sbjct: 700 DLQ---SKLRLAPDKLKSTESE-LKKKEKRRDEMLGLVPMRQSIID-------------- 741
Query: 198 VLKDGRIERLKLELERKDAEIQKLKNVITQWEAKYKEVKARNAQLLKMLQEGEMKDKAEI 257
LK+ I L+ +L+ + +IQ+LKN I + E + L + + ++ ++
Sbjct: 742 -LKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQM 800
Query: 258 LLQVDESQSIKNELTIQVTSLHAALEQERSKVKVLQAEL 296
L+ E + + +Q L ++Q + + Q +L
Sbjct: 801 ELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKL 839
Score = 33.9 bits (76), Expect = 0.19
Identities = 44/250 (17%), Positives = 108/250 (43%), Gaps = 23/250 (9%)
Query: 50 TTNEKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDLP-LSNPVQKDSRE 108
T E+ + + + + + +A +L+ + + Q+ + QH L +S+ ++ + +
Sbjct: 793 TIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKL 852
Query: 109 ENWQEWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKRK 168
Q+ +++ + L S E EK + + L+ + +E +T QS KD ++
Sbjct: 853 I--QDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKE 910
Query: 169 NHQGKDRPLTVSLKDFHSEDH--ISKKTEEVVLKDGRIERLKLELERKDAEIQKLKNVIT 226
PL +L+ F E I+KK + ++ +K +++ ++ ++N I
Sbjct: 911 QVS----PLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQ 966
Query: 227 QWEAKYKEVKARNAQLLKMLQEGEMKDKAEILLQVDESQSIKNELTIQVTSLHAALEQER 286
+ YK+ K E E+ +++ Q+ E + K ++ + + ++ ++
Sbjct: 967 DGKDDYKKQK-----------ETELN---KVIAQLSECEKHKEKINEDMRLMRQDIDTQK 1012
Query: 287 SKVKVLQAEL 296
+ + LQ L
Sbjct: 1013 IQERWLQDNL 1022
>gi|112420968 coiled-coil domain containing 158 [Homo sapiens]
Length = 1113
Score = 46.2 bits (108), Expect = 4e-05
Identities = 60/295 (20%), Positives = 131/295 (44%), Gaps = 27/295 (9%)
Query: 28 DSEPGKGKGRNTGKSQTLGSKSTTNEKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSH 87
D+E KGR L + + ++ K E ++ + + + + + +K+S
Sbjct: 230 DTEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASS 289
Query: 88 AVCNAQHDLPLSNPVQKDSREENWQEWRQ-RDEQLTSEMFEADLEKALLLSKLEYEEHKK 146
A A +Q+ +R +N RQ D + T ++L +A + + + EE +K
Sbjct: 290 ARSQANSIQSQMEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKTEELEK 349
Query: 147 EYEDAENTSTQSKVMNKKDKRKNHQGK-DRPLTVSLKDFHS-EDHISKKTEEVVLKDGR- 203
+ A + T+++ ++D+ G D L L D H E +S + E+ R
Sbjct: 350 QLVLANSELTEART--ERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRD 407
Query: 204 ------IERLKLELERKDAEIQKLKNVIT--------QWEAKYKEVKARNAQLLKMLQ-E 248
I+ L+ EL+ ++ E+Q+L+ ++ Q E + ++ +N L K+
Sbjct: 408 TGNSITIDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQMAAIQGKNESLEKVSSLT 467
Query: 249 GEMKDKAEILLQVDESQSIKNELTIQ-----VTSLHAALEQERSKVKVLQAELAK 298
+++ E+L +V E + K ++T++ ++ L +L+++ ++ AE+ K
Sbjct: 468 AQLESTKEMLRKVVEELTAK-KMTLESSERTISDLTTSLQEKERAIEATNAEITK 521
Score = 34.3 bits (77), Expect = 0.15
Identities = 58/263 (22%), Positives = 107/263 (40%), Gaps = 36/263 (13%)
Query: 39 TGKSQTLGSKSTTNEKKREKRRKKK---EQQQSEANELRNLAFKKIPQKSSHAVCNAQHD 95
T K TL S T ++K+ E +E +LR+ K+ Q+ H H
Sbjct: 485 TAKKMTLESSERTISDLTTSLQEKERAIEATNAEITKLRSRVDLKL-QELQHLKNEGDHL 543
Query: 96 LPLSNP-----VQKDSREENWQEWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYED 150
+ +Q +++ + RQ+ E +T + + + ++E + +KE D
Sbjct: 544 RNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGAM--QVEKAQLEKEIND 601
Query: 151 AENTSTQSKVMNKKDKRKNHQGKDRPLTVSLKDFHSEDHISKKTEEVVLKDGRIERLKLE 210
+ K++ KDK+ K R L + D + E+V L + ERL+
Sbjct: 602 RRMELKELKIL--KDKK---DAKIRELEARVSDL--------ELEKVKLVNAGSERLRAV 648
Query: 211 LERKDAEIQKLKNVITQWEAKYKEVKARNAQLLKMLQEGEMKDKAEILLQVDESQSIKNE 270
+ K Q L EVK ++L + +E E+ K + +E + N+
Sbjct: 649 KDIKQERDQLLN-----------EVKTSRSELNNLSEEYEVL-KRNFRNKSEEMEMTTNK 696
Query: 271 LTIQVTSLHAALEQERSKVKVLQ 293
L +Q+ S + LEQ R+ +K ++
Sbjct: 697 LKMQLKSAQSELEQTRNTLKSME 719
Score = 31.2 bits (69), Expect = 1.3
Identities = 40/179 (22%), Positives = 85/179 (47%), Gaps = 24/179 (13%)
Query: 115 RQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEY----EDAENTSTQSKVMNKKDKRKNH 170
+Q +QL +E+ + E L EYE K+ + E+ E T+ + K+ K + +
Sbjct: 652 KQERDQLLNEVKTSRSELNNLSE--EYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELE 709
Query: 171 QGKDRPLTVSLKDFHSEDHISKKTEEVVLKDGRIERLKLELERKDAEIQKLKNVITQWEA 230
Q ++ ++ D H+ +++ K G+I+ L+ ++IQ L+ +T
Sbjct: 710 QTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQ-------SKIQFLEEAMTNANK 762
Query: 231 K---YKEVKARNAQLLKML--QEGEMKDKAEILLQVDESQSIKNELTIQVTSLHAALEQ 284
+ KE K++ +Q L + ++ +M + E+L +S + L +VT++ AL++
Sbjct: 763 EKHFLKEEKSKLSQELSTVATEKNKMAGELEVL------RSQERRLKEKVTNMEVALDK 815
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.305 0.122 0.321
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,050,341
Number of Sequences: 37866
Number of extensions: 499027
Number of successful extensions: 6008
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 146
Number of HSP's successfully gapped in prelim test: 782
Number of HSP's that attempted gapping in prelim test: 4090
Number of HSP's gapped (non-prelim): 2187
length of query: 315
length of database: 18,247,518
effective HSP length: 102
effective length of query: 213
effective length of database: 14,385,186
effective search space: 3064044618
effective search space used: 3064044618
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.