Search of human proteins with 209862903

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|209862903 leucine-rich repeats and immunoglobulin-like
domains 3 isoform 1 [Homo sapiens]
         (1059 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|209862903 leucine-rich repeats and immunoglobulin-like domain...  2143   0.0  
gi|40255157 leucine-rich repeats and immunoglobulin-like domains...  2108   0.0  
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ...  1113   0.0  
gi|54607118 leucine-rich repeats and immunoglobulin-like domains...   951   0.0  
gi|109150416 peroxidasin [Homo sapiens]                               222   1e-57
gi|126517478 peroxidasin homolog-like [Homo sapiens]                  212   2e-54
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s...   159   1e-38
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa...   159   1e-38
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo...   155   2e-37
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo...   153   7e-37
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom...   149   2e-35
gi|198041768 synleurin [Homo sapiens]                                 147   7e-35
gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]            145   2e-34
gi|225579152 insulin-like growth factor binding protein, acid la...   141   4e-33
gi|4826772 insulin-like growth factor binding protein, acid labi...   141   4e-33
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]   135   3e-31
gi|122937309 leucine rich repeat containing 4B [Homo sapiens]         133   8e-31
gi|76880480 hypothetical protein LOC9865 [Homo sapiens]               131   3e-30
gi|51317373 netrin-G1 ligand [Homo sapiens]                           126   9e-29
gi|62912470 leucine-rich repeat-containing G protein-coupled rec...   125   2e-28
gi|62912472 leucine-rich repeat-containing G protein-coupled rec...   125   3e-28
gi|19743806 roundabout 1 isoform b [Homo sapiens]                     124   4e-28
gi|4506569 roundabout 1 isoform a [Homo sapiens]                      124   4e-28
gi|4758460 glycoprotein V (platelet) [Homo sapiens]                   124   6e-28
gi|118572606 hemicentin 1 [Homo sapiens]                              123   8e-28
gi|15029530 leucine rich repeat containing 4 [Homo sapiens]           121   3e-27
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]                   120   5e-27
gi|157694513 leucine-rich repeat-containing G protein-coupled re...   120   5e-27
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]                   120   7e-27
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]                   120   7e-27

>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
            isoform 1 [Homo sapiens]
          Length = 1059

 Score = 2143 bits (5552), Expect = 0.0
 Identities = 1059/1059 (100%), Positives = 1059/1059 (100%)

Query: 1    MVDVLLLFSLCLLFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS 60
            MVDVLLLFSLCLLFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS
Sbjct: 1    MVDVLLLFSLCLLFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS 60

Query: 61   ANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVT 120
            ANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVT
Sbjct: 61   ANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVT 120

Query: 121  SMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGA 180
            SMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGA
Sbjct: 121  SMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGA 180

Query: 181  LKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAIN 240
            LKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAIN
Sbjct: 181  LKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAIN 240

Query: 241  RISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSS 300
            RISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSS
Sbjct: 241  RISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSS 300

Query: 301  LKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDN 360
            LKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDN
Sbjct: 301  LKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDN 360

Query: 361  AIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKG 420
            AIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKG
Sbjct: 361  AIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKG 420

Query: 421  RSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNEL 480
            RSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNEL
Sbjct: 421  RSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNEL 480

Query: 481  LHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVN 540
            LHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVN
Sbjct: 481  LHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVN 540

Query: 541  MLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDV 600
            MLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDV
Sbjct: 541  MLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDV 600

Query: 601  FFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIA 660
            FFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIA
Sbjct: 601  FFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIA 660

Query: 661  GGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNV 720
            GGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNV
Sbjct: 661  GGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNV 720

Query: 721  RLSVIPTPTCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDC 780
            RLSVIPTPTCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDC
Sbjct: 721  RLSVIPTPTCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDC 780

Query: 781  SITNTDETNLPADIPSYLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSGT 840
            SITNTDETNLPADIPSYLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSGT
Sbjct: 781  SITNTDETNLPADIPSYLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSGT 840

Query: 841  CHIDNSSEADVEAATDLFLCPFLGSTGPMYLKGNVYGSDPFETYHTGCSPDPRTVLMDHY 900
            CHIDNSSEADVEAATDLFLCPFLGSTGPMYLKGNVYGSDPFETYHTGCSPDPRTVLMDHY
Sbjct: 841  CHIDNSSEADVEAATDLFLCPFLGSTGPMYLKGNVYGSDPFETYHTGCSPDPRTVLMDHY 900

Query: 901  EPSYIKKKECYPCSHPSEESCERSFSNISWPSHVRKLLNTSYSHNEGPGMKNLCLNKSSL 960
            EPSYIKKKECYPCSHPSEESCERSFSNISWPSHVRKLLNTSYSHNEGPGMKNLCLNKSSL
Sbjct: 901  EPSYIKKKECYPCSHPSEESCERSFSNISWPSHVRKLLNTSYSHNEGPGMKNLCLNKSSL 960

Query: 961  DFSANPEPASVASSNSFMGTFGKALRRPHLDAYSSFGQPSDCQPRAFYLKAHSSPDLDSG 1020
            DFSANPEPASVASSNSFMGTFGKALRRPHLDAYSSFGQPSDCQPRAFYLKAHSSPDLDSG
Sbjct: 961  DFSANPEPASVASSNSFMGTFGKALRRPHLDAYSSFGQPSDCQPRAFYLKAHSSPDLDSG 1020

Query: 1021 SEEDGKERTDFQEENHICTFKQTLENYRTPNFQSYDLDT 1059
            SEEDGKERTDFQEENHICTFKQTLENYRTPNFQSYDLDT
Sbjct: 1021 SEEDGKERTDFQEENHICTFKQTLENYRTPNFQSYDLDT 1059


>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
            isoform 2 [Homo sapiens]
          Length = 1119

 Score = 2108 bits (5462), Expect = 0.0
 Identities = 1041/1044 (99%), Positives = 1043/1044 (99%)

Query: 16   ISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVE 75
            ++R DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVE
Sbjct: 76   VARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVE 135

Query: 76   ILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLL 135
            ILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLL
Sbjct: 136  ILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLL 195

Query: 136  VLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLM 195
            VLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLM
Sbjct: 196  VLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLM 255

Query: 196  DGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSE 255
            DGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSE
Sbjct: 256  DGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSE 315

Query: 256  LDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTI 315
            LDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTI
Sbjct: 316  LDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTI 375

Query: 316  EDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKK 375
            EDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKK
Sbjct: 376  EDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKK 435

Query: 376  LQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDD 435
            LQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDD
Sbjct: 436  LQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDD 495

Query: 436  FPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQ 495
            FPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQ
Sbjct: 496  FPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQ 555

Query: 496  GGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIR 555
            GGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIR
Sbjct: 556  GGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIR 615

Query: 556  AGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYS 615
            AGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYS
Sbjct: 616  AGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYS 675

Query: 616  CTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDS 675
            CTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDS
Sbjct: 676  CTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDS 735

Query: 676  PLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQM 735
            PLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQM
Sbjct: 736  PLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQM 795

Query: 736  TAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNLPADIP 795
            TAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNLPADIP
Sbjct: 796  TAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNLPADIP 855

Query: 796  SYLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSGTCHIDNSSEADVEAAT 855
            SYLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSGTCHIDNSSEADVEAAT
Sbjct: 856  SYLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSGTCHIDNSSEADVEAAT 915

Query: 856  DLFLCPFLGSTGPMYLKGNVYGSDPFETYHTGCSPDPRTVLMDHYEPSYIKKKECYPCSH 915
            DLFLCPFLGSTGPMYLKGNVYGSDPFETYHTGCSPDPRTVLMDHYEPSYIKKKECYPCSH
Sbjct: 916  DLFLCPFLGSTGPMYLKGNVYGSDPFETYHTGCSPDPRTVLMDHYEPSYIKKKECYPCSH 975

Query: 916  PSEESCERSFSNISWPSHVRKLLNTSYSHNEGPGMKNLCLNKSSLDFSANPEPASVASSN 975
            PSEESCERSFSNISWPSHVRKLLNTSYSHNEGPGMKNLCLNKSSLDFSANPEPASVASSN
Sbjct: 976  PSEESCERSFSNISWPSHVRKLLNTSYSHNEGPGMKNLCLNKSSLDFSANPEPASVASSN 1035

Query: 976  SFMGTFGKALRRPHLDAYSSFGQPSDCQPRAFYLKAHSSPDLDSGSEEDGKERTDFQEEN 1035
            SFMGTFGKALRRPHLDAYSSFGQPSDCQPRAFYLKAHSSPDLDSGSEEDGKERTDFQEEN
Sbjct: 1036 SFMGTFGKALRRPHLDAYSSFGQPSDCQPRAFYLKAHSSPDLDSGSEEDGKERTDFQEEN 1095

Query: 1036 HICTFKQTLENYRTPNFQSYDLDT 1059
            HICTFKQTLENYRTPNFQSYDLDT
Sbjct: 1096 HICTFKQTLENYRTPNFQSYDLDT 1119


>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
           [Homo sapiens]
          Length = 1065

 Score = 1113 bits (2880), Expect = 0.0
 Identities = 568/902 (62%), Positives = 705/902 (78%), Gaps = 13/902 (1%)

Query: 20  DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPE 79
           D SHNRLS    S  S  Q+L+EVK+N NEL  IP  G  ++NITLLSL  N I EI  +
Sbjct: 81  DFSHNRLSNWNISLES--QTLQEVKMNYNELTEIPYFGEPTSNITLLSLVHNIIPEINAQ 138

Query: 80  HLKEFQSLETLDLSSNNISELQTA-FPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLK 138
            L+ + +LE+LDLSSN ISE++T+ FP +QLKYL L++NR+T++E G FDNL+++LLV+K
Sbjct: 139 ALQFYPALESLDLSSNIISEIKTSSFPRMQLKYLNLSNNRITTLEAGCFDNLSSSLLVVK 198

Query: 139 LNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGA 198
           LNRNR+S IPPK+FKLP LQ LEL RN+IK V+GLTFQGL +L+SLKMQRNG++KL DGA
Sbjct: 199 LNRNRMSMIPPKIFKLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGA 258

Query: 199 FWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDL 258
           F+GL+NME L+L+HNNLT + KGWLYGL MLQ+L++SQNAI RISPDAWEFCQ+LSELDL
Sbjct: 259 FFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDL 318

Query: 259 TFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDM 318
           ++N L+RLD+S+F+GLSLL  L++G+NRV++IAD  FR LS+L+TLDL+NNEISW IED 
Sbjct: 319 SYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDA 378

Query: 319 NGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQ 378
           + AF+GL  L +LILQGN+I+SITKKAF GL++LEHLDL++NAIMS+Q NAFSQ   L++
Sbjct: 379 SEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQTH-LKE 437

Query: 379 LHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPK 438
           L LNTSSLLCDC LKWL QW+ +NNFQ  VN SCAHP+ L G+SI  V    FVCDDF K
Sbjct: 438 LILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVSCAHPEWLAGQSILNVDLKDFVCDDFLK 497

Query: 439 PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 498
           PQI   PET  A++G N++  C+A SSSDSPM+  W+KD+E+L+D + EN+     Q GE
Sbjct: 498 PQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGE 557

Query: 499 VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGA 558
            +EYT+IL L  V F  EGKYQC+++NHFGS+YS KAKLTVN +PSF KTPMDLTIR GA
Sbjct: 558 ALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTGA 617

Query: 559 MARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTA 618
           MARLECAA GHPAPQI+WQKDGGTDFPAARERRMHVMPEDDVFFI +VKIED+G+YSC A
Sbjct: 618 MARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMA 677

Query: 619 QNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLV 678
           QN+AG +SANA+LTVLETPSF+RPL D+TVT+GETAVLQCIAGGSP P+LNWTKDD PL+
Sbjct: 678 QNTAGGLSANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLL 737

Query: 679 VTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQMTAP 738
           VTERHFFAA NQLLIIVD+ + DAGKYTC MSNTLGTERG++ L+VI +P CDS Q ++ 
Sbjct: 738 VTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNVISSPNCDSSQ-SSI 796

Query: 739 SLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNLPADIPSYL 798
             +DDGW TVG+VII VVCCVVGTSL+WV++IYH RR+NED SITNT+E NLPADIPSYL
Sbjct: 797 GHEDDGWTTVGIVIIVVVCCVVGTSLIWVIVIYHMRRKNEDYSITNTEELNLPADIPSYL 856

Query: 799 SSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSGTCHI--DNSSEADVEAATD 856
           SSQGTL++ Q+GY +SE+GSH Q +  +           +GT  I  D    A++ + T 
Sbjct: 857 SSQGTLSEPQEGYSNSEAGSHQQLMPPANGYIHKGTDGGTGTRVICSDCYDNANIYSRTR 916

Query: 857 LFLCPFLGSTGPMYLK---GNVYGSDPFETYHTGCSPDPRTVLMDHYEPSYIKKKECYPC 913
            + CP+        L     ++    P ETY     P   T  ++   PS  ++   +P 
Sbjct: 917 EY-CPYTYIAEEDVLDQTLSSLMVQMPKETYLV--HPPQDTTALESLIPSANREPSAFPT 973

Query: 914 SH 915
           +H
Sbjct: 974 NH 975



 Score = 67.4 bits (163), Expect = 7e-11
 Identities = 56/239 (23%), Positives = 108/239 (45%), Gaps = 30/239 (12%)

Query: 15  HISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIV 74
           H+   +L  NR+  ++  +   L SLR +K+  N +  + +      N            
Sbjct: 216 HLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLN------------ 263

Query: 75  EILPEHLKEFQSLETLDLSSNNISELQTA--FPALQLKYLYLNSNRVTSMEPGYFDNLAN 132
                      ++E L+L  NN++ +     +    L+ LY++ N +  + P  ++    
Sbjct: 264 -----------NMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWE-FCQ 311

Query: 133 TLLVLKLNRNRISAIPPKMF-KLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGV 191
            L  L L+ N+++ +    F  L  L+ L L  N++ ++    F+ L  L++L ++ N +
Sbjct: 312 RLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEI 371

Query: 192 TKLMDG---AFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAW 247
           +  ++    AF GL+++  L L  N +  ITK    GL  L+ L L+ NAI  I  +A+
Sbjct: 372 SWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAF 430


>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
            [Homo sapiens]
          Length = 1093

 Score =  951 bits (2459), Expect = 0.0
 Identities = 515/984 (52%), Positives = 666/984 (67%), Gaps = 38/984 (3%)

Query: 20   DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPE 79
            +LS+N+LS I  +    L +L+EV LNNNEL  +P+LG  S+++  L L  N+I  +   
Sbjct: 74   NLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLQHNKIRSVEGS 133

Query: 80   HLKEFQSLETLDLSSNNISELQ-TAFP-ALQLKYLYLNSNRVTSMEPGYFDNLANTLLVL 137
             LK + SLE LDLS NNI+E++ T FP    +K L L  NR+ ++E G FD L+ +LL L
Sbjct: 134  QLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTL 193

Query: 138  KLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDG 197
            +L++NRI+ +P + FKLP+L  L+LNRN+I+ ++GLTFQGL +L+ LK+QRN ++KL DG
Sbjct: 194  RLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDG 253

Query: 198  AFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELD 257
            AFWGLS M +L L++N+L E+  G LYGL  L +LHLS N+I RI    W FCQKL EL 
Sbjct: 254  AFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELV 313

Query: 258  LTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIED 317
            L+FN+L+RLD+ S   LS L+ L + +N +S+IA+ AF+GL SL+ LDL +NEIS TIED
Sbjct: 314  LSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIED 373

Query: 318  MNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQ 377
             +GAFSGLD L +L L GN+I+S+ K+AF+GL+ LEHL+L  NAI S+Q +AF +MK L+
Sbjct: 374  TSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLK 433

Query: 378  QLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFP 437
            +LH+++ S LCDCQLKWLP W+     Q+FV A+CAHP+ LKG+SIF+V P+ FVCDDF 
Sbjct: 434  ELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSIFSVPPESFVCDDFL 493

Query: 438  KPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGG 497
            KPQI  QPET  A+ G ++ F CSAASSS SPMTFAWKKDNE+L +A+MEN+ H+ AQ G
Sbjct: 494  KPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDG 553

Query: 498  EVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAG 557
            EVMEYTTIL LR+V F  EG+YQCVI+NHFGS+YS KA+LTVN+LPSFTKTP D+TIR  
Sbjct: 554  EVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTT 613

Query: 558  AMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCT 617
             MARLECAA GHP PQIAWQKDGGTDFPAARERRMHVMP+DDVFFI DVKI+D GVYSCT
Sbjct: 614  TMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCT 673

Query: 618  AQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPL 677
            AQNSAGSISANATLTVLETPS + PL DR V+ GET  LQC A G+PPP++ W K D PL
Sbjct: 674  AQNSAGSISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFKGDRPL 733

Query: 678  VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQMTA 737
             +TERH     NQLL++ +    DAG+YTCEMSNTLGTER + +LSV+P   C       
Sbjct: 734  SLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSVLPAAGCRK----- 788

Query: 738  PSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNLPADIPSY 797
                 DG  TVG+  IAVV  +V TSLVWV IIY TR+++E+ S+TNTDET +P D+PSY
Sbjct: 789  -----DG-TTVGIFTIAVVSSIVLTSLVWVCIIYQTRKKSEEYSVTNTDETVVPPDVPSY 842

Query: 798  LSSQGTLADRQDGYVSSESGSH-HQFVTSSGAGFFLPQHDSSGTCHIDNSSEADVEAATD 856
            LSSQGTL+DRQ+  V +E G   +  + S+G       H      H     +  + A + 
Sbjct: 843  LSSQGTLSDRQETVVRTEGGPQANGHIESNGVCPRDASHFPEPDTHSVACRQPKLCAGSA 902

Query: 857  LFLCPFL------GSTGPMYLK--GNVYGSD---PFETYHTGCSPDPRTVLMDHYEPSYI 905
                P+       G+ GP  ++  G V  SD     + Y  G +  P+ V  D  +PS  
Sbjct: 903  YHKEPWKAMEKAEGTPGPHKMEHGGRVVCSDCNTEVDCYSRGQAFHPQPVSRDSAQPSAP 962

Query: 906  KKKE----------CYPCSHPSEESCERSFSNISWPSHVRKLL---NTSYSHNEGPGMKN 952
               E           + CS  +  SC     ++   +H R L        +  +G G  +
Sbjct: 963  NGPEPGGSDQEHSPHHQCSRTAAGSCPECQGSLYPSNHDRMLTAVKKKPMASLDGKGDSS 1022

Query: 953  LCLNKSSLDFSANPEPASVASSNS 976
              L +     S   +PAS  +S S
Sbjct: 1023 WTLARLYHPDSTELQPASSLTSGS 1046



 Score =  124 bits (311), Expect = 5e-28
 Identities = 156/648 (24%), Positives = 261/648 (40%), Gaps = 108/648 (16%)

Query: 16  ISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPV--SANITLLSLAGNRI 73
           +++ DL+ NR+  I+  +   L SL  +KL  N +  + + G     + + +L L  N +
Sbjct: 213 LTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTD-GAFWGLSKMHVLHLEYNSL 271

Query: 74  VEILPEHLKEFQSLETLDLSSNNISELQTAFPAL--QLKYLYLNSNRVTSMEPGYFDNLA 131
           VE+    L    +L  L LS+N+I+ +     +   +L  L L+ N +T ++      L 
Sbjct: 272 VEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAEL- 330

Query: 132 NTLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNG 190
           ++L VL+L+ N IS I    FK L  L+ L+L+ N+I                     +G
Sbjct: 331 SSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEI---------------------SG 369

Query: 191 VTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFC 250
             +   GAF GL ++  L L  N +  + K    GL  L+ L+L  NAI  +  DA    
Sbjct: 370 TIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDA---- 425

Query: 251 QKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNE 310
                               F+ +  L  LHI ++  S++ DC  + L            
Sbjct: 426 --------------------FVKMKNLKELHISSD--SFLCDCQLKWLP----------- 452

Query: 311 ISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALE-HLDLSDNAIMSLQGNA 369
             W I  M  AF          L+G  I S+  ++F   D L+  +       M++ G  
Sbjct: 453 -PWLIGRMLQAFVTATCAHPESLKGQSIFSVPPESFVCDDFLKPQIITQPETTMAMVG-- 509

Query: 370 FSQMKKLQQLHLNTSSLLCDCQLKWLP--QWVAENNFQSFVNASCAHPQLLKGRSIF--- 424
               K ++      SS        W    + +   + ++FV+      ++++  +I    
Sbjct: 510 ----KDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGEVMEYTTILHLR 565

Query: 425 -----------AVSPDGFVCDDFPKPQITV-------QPETQSAIKGSNLSFICSAASSS 466
                       V  + F      K ++TV       +      I+ + ++ +  AA+  
Sbjct: 566 QVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTTTMARLECAATGH 625

Query: 467 DSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNH 526
            +P   AW+KD      A  E   H       VM    +  + +V+    G Y C   N 
Sbjct: 626 PNPQ-IAWQKDGGTDFPAARERRMH-------VMPDDDVFFITDVKIDDAGVYSCTAQNS 677

Query: 527 FGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPA 586
            G S S  A LTV   PS      D  +  G    L+C A G+P P+I W K    D P 
Sbjct: 678 AG-SISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFKG---DRPL 733

Query: 587 ARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVL 634
           +   R H+ P++ +  + +V  ED G Y+C   N+ G+  A++ L+VL
Sbjct: 734 SLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSVL 781



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 37/115 (32%), Positives = 62/115 (53%), Gaps = 6/115 (5%)

Query: 9   SLCLLFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELE-TIPNLGPVSA---NIT 64
           SL  L  +S   LSHN +S I   +   L+SLR + L++NE+  TI +     +   +++
Sbjct: 326 SLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLS 385

Query: 65  LLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQ-TAFPALQ-LKYLYLNSN 117
            L+L GN+I  +        + LE L+L  N I  +Q  AF  ++ LK L+++S+
Sbjct: 386 KLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELHISSD 440


>gi|109150416 peroxidasin [Homo sapiens]
          Length = 1479

 Score =  222 bits (566), Expect = 1e-57
 Identities = 153/505 (30%), Positives = 247/505 (48%), Gaps = 37/505 (7%)

Query: 232 LHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIA 291
           +HL   A+  ++P         S LDL FN +  +   +F  L  LNTL + NN++  I 
Sbjct: 50  MHLLLEAVPAVAPQT-------SILDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIP 102

Query: 292 DCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDA 351
             AF  L +LK L L  NEI  +I+    AF GL  L +L L  N+I ++   +F  L  
Sbjct: 103 SGAFEDLENLKYLYLYKNEIQ-SIDRQ--AFKGLASLEQLYLHFNQIETLDPDSFQHLPK 159

Query: 352 LEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQ----WVAENNFQSF 407
           LE L L +N I  L    F+ ++ +++L L++++L CDC++ WL      +    N Q+ 
Sbjct: 160 LERLFLHNNRITHLVPGTFNHLESMKRLRLDSNTLHCDCEILWLADLLKTYAESGNAQAA 219

Query: 408 VNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSD 467
             A C +P+ ++GRS+  ++P+   C+   +P+IT +P+      G+ + F C A   + 
Sbjct: 220 --AICEYPRRIQGRSVATITPEELNCE---RPRITSEPQDADVTSGNTVYFTCRA-EGNP 273

Query: 468 SPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHF 527
            P     + +NEL    + ++  +L   G         L ++  +   +G YQC+  N  
Sbjct: 274 KPEIIWLRNNNEL--SMKTDSRLNLLDDG--------TLMIQNTQETDQGIYQCMAKNVA 323

Query: 528 GSSYSVKAKLTV---NMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDF 584
           G   + +  L        P+F   P +  +  G    LEC+A GHP P+I+W +   T  
Sbjct: 324 GEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPL 383

Query: 585 PAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLL 644
           P   + R+++ P   ++ I +V   D G Y+C+A N+  S+ A A + V   P F     
Sbjct: 384 PV--DPRVNITPSGGLY-IQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQ 440

Query: 645 DRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGK 704
           DR V +G+T   QC A G+PPP + WTK  S L V  RH   +   L  I    + D G+
Sbjct: 441 DRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLR-ISGVALHDQGQ 499

Query: 705 YTCEMSNTLGTERGNVRLSVIPTPT 729
           Y C+  N +G+++    L+V P  T
Sbjct: 500 YECQAVNIIGSQKVVAHLTVQPRVT 524



 Score =  157 bits (398), Expect = 4e-38
 Identities = 158/592 (26%), Positives = 245/592 (41%), Gaps = 65/592 (10%)

Query: 184 LKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRIS 243
           L ++ N + ++  GAF  L N+  L L++N +  I  G    L  L+ L+L +N I  I 
Sbjct: 67  LDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSID 126

Query: 244 PDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKT 303
             A++    L +L L FN +  LD  SF  L  L  L + NNR++++    F  L S+K 
Sbjct: 127 RQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLESMKR 186

Query: 304 LDLKNN------EISWTI-------EDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLD 350
           L L +N      EI W         E  N   + + +  R I QG  + +IT +      
Sbjct: 187 LRLDSNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPRRI-QGRSVATITPEELNCER 245

Query: 351 ALEHLDLSDNAIMS---------LQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLP----- 396
                +  D  + S          +GN   ++  L+  + N  S+  D +L  L      
Sbjct: 246 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLR--NNNELSMKTDSRLNLLDDGTLM 303

Query: 397 ----QWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIK 452
               Q   +  +Q          +  +    +  SP         +P   +QP+    + 
Sbjct: 304 IQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSP--------ARPTFVIQPQNTEVLV 355

Query: 453 GSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVE 512
           G +++  CSA  +   P   +W + +       ++   ++   GG        L ++ V 
Sbjct: 356 GESVTLECSA--TGHPPPRISWTRGDRT--PLPVDPRVNITPSGG--------LYIQNVV 403

Query: 513 FASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAP 572
               G+Y C  +N+  S ++  A + V  LP FT TP D  +  G     +C A G+P P
Sbjct: 404 QGDSGEYACSATNNIDSVHAT-AFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPP 462

Query: 573 QIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLT 632
            IAW K GG+     R    H++       I  V + D G Y C A N  GS    A LT
Sbjct: 463 VIAWTK-GGSQLSVDRR---HLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLT 518

Query: 633 VLE--TPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTER-HFFAAGN 689
           V    TP F     D TV  G    L C + G P P + W KD   + VTE   F  +  
Sbjct: 519 VQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDG--VQVTESGKFHISPE 576

Query: 690 QLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSV-IPTPTCDSPQMTAPSL 740
             L I D   +DAG+Y C   NT+G+   ++ LSV +P  + +     A S+
Sbjct: 577 GFLTINDVGPADAGRYECVARNTIGSASVSMVLSVNVPDVSRNGDPFVATSI 628



 Score = 71.2 bits (173), Expect = 5e-12
 Identities = 49/144 (34%), Positives = 76/144 (52%), Gaps = 4/144 (2%)

Query: 100 LQTAFPAL--QLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQ 156
           L  A PA+  Q   L L  NR+  ++PG F  L N L  L LN N+I  IP   F+ L  
Sbjct: 53  LLEAVPAVAPQTSILDLRFNRIREIQPGAFRRLRN-LNTLLLNNNQIKRIPSGAFEDLEN 111

Query: 157 LQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLT 216
           L++L L +N+I+++D   F+GL +L+ L +  N +  L   +F  L  +E L L +N +T
Sbjct: 112 LKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRIT 171

Query: 217 EITKGWLYGLLMLQELHLSQNAIN 240
            +  G    L  ++ L L  N ++
Sbjct: 172 HLVPGTFNHLESMKRLRLDSNTLH 195



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 44/129 (34%), Positives = 71/129 (55%), Gaps = 6/129 (4%)

Query: 20  DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS--ANITLLSLAGNRIVEIL 77
           DL  NR+  I+  +   L++L  + LNNN+++ IP+ G      N+  L L  N I  I 
Sbjct: 68  DLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPS-GAFEDLENLKYLYLYKNEIQSID 126

Query: 78  PEHLKEFQSLETLDLSSNNISELQ-TAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLL 135
            +  K   SLE L L  N I  L   +F  L +L+ L+L++NR+T + PG F++L  ++ 
Sbjct: 127 RQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHL-ESMK 185

Query: 136 VLKLNRNRI 144
            L+L+ N +
Sbjct: 186 RLRLDSNTL 194


>gi|126517478 peroxidasin homolog-like [Homo sapiens]
          Length = 1463

 Score =  212 bits (539), Expect = 2e-54
 Identities = 144/481 (29%), Positives = 234/481 (48%), Gaps = 28/481 (5%)

Query: 251 QKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNE 310
           Q+ + LDL FN +  +  S+F  L  LNTL + NN +  I+  AF GL +L  L L  NE
Sbjct: 50  QQTTVLDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNE 109

Query: 311 ISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAF 370
           I    +     F GL  L  L +  N++  +  + F  L  LE L L +N +  +   +F
Sbjct: 110 IHALDKQ---TFKGLISLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSF 166

Query: 371 SQMKKLQQLHLNTSSLLCDCQLKWLPQWVA--ENNFQSFVNASCAHPQLLKGRSIFAVSP 428
           S +  L++L L++++L+CDC L WL + +     +  +   A+C +P+ L GR++ +V+ 
Sbjct: 167 SNLDSLKRLRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAATCEYPRRLHGRAVASVTV 226

Query: 429 DGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMEN 488
           + F C     P+IT +P+      G+ + F C A  +    +   W  +N   H  ++E+
Sbjct: 227 EEFNCQ---SPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEI--IWIHNN---HSLDLED 278

Query: 489 YAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNML---PSF 545
              L      V +  T++ +R    + +G YQC+  N  G + +  A L  + L   PSF
Sbjct: 279 DTRL-----NVFDDGTLM-IRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSF 332

Query: 546 TKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVD 605
              P D  +  G    LEC A GHP P I W +D G +   +R    HV     + ++ +
Sbjct: 333 VIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSR----HVATSSGL-YLQN 387

Query: 606 VKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPP 665
           +   D G ++C A NS G++ A A + V   P F     D+ V +       C A G+PP
Sbjct: 388 ITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPP 447

Query: 666 PKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVI 725
           P + WTK    L V  +H   +   L I   +   D G+Y C+  ++LG ++ +V+L+V 
Sbjct: 448 PVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAAQ-HDQGQYECQAVSSLGVKKVSVQLTVK 506

Query: 726 P 726
           P
Sbjct: 507 P 507



 Score =  128 bits (321), Expect = 3e-29
 Identities = 145/600 (24%), Positives = 231/600 (38%), Gaps = 92/600 (15%)

Query: 160 LELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEIT 219
           L+L  N+I+ + G  F+ L  L +L +  N + K+   AF GL N+  L L  N +  + 
Sbjct: 55  LDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALD 114

Query: 220 KGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNT 279
           K    GL+ L+ L++  N +  + P+             TF  L RL+            
Sbjct: 115 KQTFKGLISLEHLYIHFNQLEMLQPE-------------TFGDLLRLE-----------R 150

Query: 280 LHIGNNRVSYIADCAFRGLSSLKTLDLKNN------EISWTIEDMNG--------AFSGL 325
           L + NN++S I   +F  L SLK L L +N      ++ W  E + G        A +  
Sbjct: 151 LFLHNNKLSKIPAGSFSNLDSLKRLRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAATC 210

Query: 326 DKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAF--------SQMKKLQ 377
           +  RRL   G  + S+T + F         +  D  + S  GN          +   ++ 
Sbjct: 211 EYPRRL--HGRAVASVTVEEFNCQSPRITFEPQDVEVPS--GNTVYFTCRAEGNPKPEII 266

Query: 378 QLHLNTS-SLLCDCQLKWLPQWVA---------ENNFQSFVNASCAHPQLLKGRSIFAVS 427
            +H N S  L  D +L                 +  +Q     S    +       ++  
Sbjct: 267 WIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSL 326

Query: 428 PDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEME 487
           P         KP   +QP+    + G++ +  C A       +T  W +DN L    E++
Sbjct: 327 P--------AKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLIT--WTRDNGL----ELD 372

Query: 488 NYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTK 547
              H+    G        L L+ +     G++ C  +N  G+  +  A + V   P FT 
Sbjct: 373 GSRHVATSSG--------LYLQNITQRDHGRFTCHANNSHGTVQAA-ANIIVQAPPQFTV 423

Query: 548 TPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVK 607
           TP D  +         C A G+P P I W K GG   P   +   H +       I    
Sbjct: 424 TPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGG-QLPVEGQ---HTVLSSGTLRIDRAA 479

Query: 608 IEDIGVYSCTAQNSAG--SISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPP 665
             D G Y C A +S G   +S   T+       F +   D +V  G+   + C A G P 
Sbjct: 480 QHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQ 539

Query: 666 PKLNWTKDDSPLVVTERHFFAAGNQ-LLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSV 724
           P + W K+   + +TE   F   ++  L I D+   D G+Y C   N+ G    N+ L+V
Sbjct: 540 PIITWNKEG--VQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTV 597



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 97/414 (23%), Positives = 162/414 (39%), Gaps = 65/414 (15%)

Query: 331 LILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDC 390
           L L+ NRIR I   AF  L  L  L L++N I  +  NAF  ++ L  L+L  + +    
Sbjct: 55  LDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALD 114

Query: 391 QLKWLPQWVAENNFQSFVNASCAHPQ----LLKGRSIFAVSPDGFVCDDFPKPQITVQPE 446
           +  +      E+ +  F       P+    LL+   +F                      
Sbjct: 115 KQTFKGLISLEHLYIHFNQLEMLQPETFGDLLRLERLF---------------------- 152

Query: 447 TQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEM-------ENYA-HLRAQGGE 498
               +  + LS I + + S+   +       N L+ D ++       + +A H   Q   
Sbjct: 153 ----LHNNKLSKIPAGSFSNLDSLKRLRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAA 208

Query: 499 VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGA 558
             EY   L  R V   +  ++ C                     P  T  P D+ + +G 
Sbjct: 209 TCEYPRRLHGRAVASVTVEEFNC-------------------QSPRITFEPQDVEVPSGN 249

Query: 559 MARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTA 618
                C A G+P P+I W  +  +      + R++V  +D    I + +  D GVY C A
Sbjct: 250 TVYFTCRAEGNPKPEIIWIHNNHS-LDLEDDTRLNVF-DDGTLMIRNTRESDQGVYQCMA 307

Query: 619 QNSAGSISANATL----TVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDD 674
           +NSAG     + +    ++   PSF+    D  V  G +  L+C+A G P P + WT+D+
Sbjct: 308 RNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDN 367

Query: 675 SPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728
              +   RH   A +  L + +    D G++TC  +N+ GT +    + V   P
Sbjct: 368 GLELDGSRH--VATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPP 419



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 44/142 (30%), Positives = 79/142 (55%), Gaps = 4/142 (2%)

Query: 53  IPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISEL-QTAFPALQ-LK 110
           + ++  V    T+L L  NRI EI     K+ ++L TL L++N+I ++ + AF  L+ L 
Sbjct: 42  LDHIPQVPQQTTVLDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLL 101

Query: 111 YLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMF-KLPQLQHLELNRNKIKN 169
           YLYL  N + +++   F  L  +L  L ++ N++  + P+ F  L +L+ L L+ NK+  
Sbjct: 102 YLYLYKNEIHALDKQTFKGLI-SLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSK 160

Query: 170 VDGLTFQGLGALKSLKMQRNGV 191
           +   +F  L +LK L++  N +
Sbjct: 161 IPAGSFSNLDSLKRLRLDSNAL 182



 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 41/128 (32%), Positives = 66/128 (51%), Gaps = 4/128 (3%)

Query: 20  DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIP-NLGPVSANITLLSLAGNRIVEILP 78
           DL  NR+  I  S+   L++L  + LNNN +  I  N      N+  L L  N I  +  
Sbjct: 56  DLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDK 115

Query: 79  EHLKEFQSLETLDLSSNNISELQ--TAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLV 136
           +  K   SLE L +  N +  LQ  T    L+L+ L+L++N+++ +  G F NL ++L  
Sbjct: 116 QTFKGLISLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSFSNL-DSLKR 174

Query: 137 LKLNRNRI 144
           L+L+ N +
Sbjct: 175 LRLDSNAL 182


>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
           sapiens]
          Length = 587

 Score =  159 bits (402), Expect = 1e-38
 Identities = 128/437 (29%), Positives = 218/437 (49%), Gaps = 23/437 (5%)

Query: 23  HNRLSFIKASSMSHLQSLREVKLNNNELETIP-----NLGPVSANITLLSLAGNRIVEIL 77
           +  ++ +  S   ++ +L  +++  NEL  I      NLG    ++  LSLA N++ ++L
Sbjct: 68  NTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLG----SLRYLSLANNKL-QVL 122

Query: 78  PEHLKE-FQSLETLDLSSNNISELQTAF--PALQLKYLYLNSNRVTSMEPGYFDNLANTL 134
           P  L +   SLE+L LSSN + ++Q A       LK L L+ N +  +  G FD+L   L
Sbjct: 123 PIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVG-L 181

Query: 135 LVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTK 193
             L L +N ++ I P++F+ L  LQ L L  N++ ++   TF GL  L+ L +Q+N +  
Sbjct: 182 TKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGL 241

Query: 194 LMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKL 253
           L  G F    N++ L L +N+++++       L  L  L L  N++  +S   +     L
Sbjct: 242 LSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNL 301

Query: 254 SELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISW 313
            EL L  NH+S L D+ F  L  L  L +  N++S+I+  AF GL+ L+ L L  N    
Sbjct: 302 RELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTN---- 357

Query: 314 TIEDMNG-AFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQ 372
            ++D++G  F  L  L+ + LQ NR+R +    F  ++ L  + L +N + +L    F  
Sbjct: 358 ALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDH 417

Query: 373 MKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNA--SCAHPQLLKGRSIFAVSPDG 430
           + KL +L L  +   CD  +  L  W+  N  +   +    C  P  ++G+S+  ++ + 
Sbjct: 418 LGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNV 477

Query: 431 FVCDDFPKPQITVQPET 447
            V      P++   PET
Sbjct: 478 AV-PSVHVPEVPSYPET 493



 Score =  143 bits (361), Expect = 7e-34
 Identities = 110/348 (31%), Positives = 172/348 (49%), Gaps = 9/348 (2%)

Query: 42  EVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQ 101
           +V+     +  +P   P+  N   L +    I E+         +L  L +  N +S + 
Sbjct: 42  QVECTGARIVAVPT--PLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRIT 99

Query: 102 T-AFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMF-KLPQLQ 158
             AF  L  L+YL L +N++  +  G F  L ++L  L L+ N++  I P  F +   L+
Sbjct: 100 PGAFRNLGSLRYLSLANNKLQVLPIGLFQGL-DSLESLLLSSNQLLQIQPAHFSQCSNLK 158

Query: 159 HLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEI 218
            L+L+ N ++ +    F  L  L  L + +N +T +    F  L N+++L+L  N LT+I
Sbjct: 159 ELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDI 218

Query: 219 TKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLN 278
             G   GL+ LQEL L QN I  +SP  +     L  L L+ NH+S+L  S F+ L  LN
Sbjct: 219 PMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLN 278

Query: 279 TLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRI 338
            L +  N +  ++   F  + +L+ L L +N IS ++ D    FS L +L+ LIL  N+I
Sbjct: 279 RLTLFGNSLKELSLGIFGPMPNLRELWLYDNHIS-SLPD--NVFSNLRQLQVLILSRNQI 335

Query: 339 RSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 386
             I+  AF GL  L  L L  NA+  L GN F  +  LQ + L  + L
Sbjct: 336 SFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRL 383



 Score =  140 bits (352), Expect = 8e-33
 Identities = 112/381 (29%), Positives = 183/381 (48%), Gaps = 9/381 (2%)

Query: 9   SLCLLFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSL 68
           S C     S+ + +  R+  +      +  SL+ +  +  EL   P L  +SA I L  +
Sbjct: 33  SECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLN-ISALIAL-RI 90

Query: 69  AGNRIVEILPEHLKEFQSLETLDLSSNNISELQTA-FPALQ-LKYLYLNSNRVTSMEPGY 126
             N +  I P   +   SL  L L++N +  L    F  L  L+ L L+SN++  ++P +
Sbjct: 91  EKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAH 150

Query: 127 FDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLK 185
           F   +N L  L+L+ N +  IP   F  L  L  L L +N + ++    FQ LG L+ L+
Sbjct: 151 FSQCSN-LKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLR 209

Query: 186 MQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPD 245
           +  N +T +  G F GL N++ L L  N +  ++ G  +    LQ L+LS N I+++ P 
Sbjct: 210 LYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPS 269

Query: 246 AWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLD 305
            +    +L+ L L  N L  L    F  +  L  L + +N +S + D  F  L  L+ L 
Sbjct: 270 IFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLI 329

Query: 306 LKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSL 365
           L  N+IS+      GAF+GL +LR L L  N ++ +    F  L  L+++ L +N +  L
Sbjct: 330 LSRNQISFISP---GAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQL 386

Query: 366 QGNAFSQMKKLQQLHLNTSSL 386
            GN F+ +  L  + L  + L
Sbjct: 387 PGNIFANVNGLMAIQLQNNQL 407



 Score =  119 bits (297), Expect = 2e-26
 Identities = 108/345 (31%), Positives = 164/345 (47%), Gaps = 34/345 (9%)

Query: 21  LSHNRLSFIKASSMSHLQSLREVKLNNNELETIP-NLGPVSANITLLSLAGNRIVEILPE 79
           +  N LS I   +  +L SLR + L NN+L+ +P  L     ++  L L+ N++++I P 
Sbjct: 90  IEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPA 149

Query: 80  HLKEFQSLETLDLSSNNISELQT-AFPALQ-LKYLYLNSNRVTSMEPGYFDNLANTLLVL 137
           H  +  +L+ L L  N++  +   AF  L  L  L L  N +T + P  F +L N L VL
Sbjct: 150 HFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGN-LQVL 208

Query: 138 KLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMD 196
           +L  NR++ IP   F  L  LQ L L +N+I  +    F     L+ L +  N +++L  
Sbjct: 209 RLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPP 268

Query: 197 GAFWGLSNMEILQLDHNNLTEITKG-----------WLY-------------GLLMLQEL 232
             F  L  +  L L  N+L E++ G           WLY              L  LQ L
Sbjct: 269 SIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVL 328

Query: 233 HLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIAD 292
            LS+N I+ ISP A+    +L EL L  N L  LD + F  L+ L  + + NNR+  +  
Sbjct: 329 ILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPG 388

Query: 293 CAFRGLSSLKTLDLKNNEISWTIEDMN-GAFSGLDKLRRLILQGN 336
             F  ++ L  + L+NN+    +E++  G F  L KL  L L  N
Sbjct: 389 NIFANVNGLMAIQLQNNQ----LENLPLGIFDHLGKLCELRLYDN 429


>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
           sapiens]
          Length = 581

 Score =  159 bits (402), Expect = 1e-38
 Identities = 128/437 (29%), Positives = 218/437 (49%), Gaps = 23/437 (5%)

Query: 23  HNRLSFIKASSMSHLQSLREVKLNNNELETIP-----NLGPVSANITLLSLAGNRIVEIL 77
           +  ++ +  S   ++ +L  +++  NEL  I      NLG    ++  LSLA N++ ++L
Sbjct: 62  NTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLG----SLRYLSLANNKL-QVL 116

Query: 78  PEHLKE-FQSLETLDLSSNNISELQTAF--PALQLKYLYLNSNRVTSMEPGYFDNLANTL 134
           P  L +   SLE+L LSSN + ++Q A       LK L L+ N +  +  G FD+L   L
Sbjct: 117 PIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVG-L 175

Query: 135 LVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTK 193
             L L +N ++ I P++F+ L  LQ L L  N++ ++   TF GL  L+ L +Q+N +  
Sbjct: 176 TKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGL 235

Query: 194 LMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKL 253
           L  G F    N++ L L +N+++++       L  L  L L  N++  +S   +     L
Sbjct: 236 LSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNL 295

Query: 254 SELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISW 313
            EL L  NH+S L D+ F  L  L  L +  N++S+I+  AF GL+ L+ L L  N    
Sbjct: 296 RELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTN---- 351

Query: 314 TIEDMNG-AFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQ 372
            ++D++G  F  L  L+ + LQ NR+R +    F  ++ L  + L +N + +L    F  
Sbjct: 352 ALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDH 411

Query: 373 MKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNA--SCAHPQLLKGRSIFAVSPDG 430
           + KL +L L  +   CD  +  L  W+  N  +   +    C  P  ++G+S+  ++ + 
Sbjct: 412 LGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNV 471

Query: 431 FVCDDFPKPQITVQPET 447
            V      P++   PET
Sbjct: 472 AV-PSVHVPEVPSYPET 487



 Score =  143 bits (361), Expect = 7e-34
 Identities = 110/348 (31%), Positives = 172/348 (49%), Gaps = 9/348 (2%)

Query: 42  EVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQ 101
           +V+     +  +P   P+  N   L +    I E+         +L  L +  N +S + 
Sbjct: 36  QVECTGARIVAVPT--PLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRIT 93

Query: 102 T-AFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMF-KLPQLQ 158
             AF  L  L+YL L +N++  +  G F  L ++L  L L+ N++  I P  F +   L+
Sbjct: 94  PGAFRNLGSLRYLSLANNKLQVLPIGLFQGL-DSLESLLLSSNQLLQIQPAHFSQCSNLK 152

Query: 159 HLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEI 218
            L+L+ N ++ +    F  L  L  L + +N +T +    F  L N+++L+L  N LT+I
Sbjct: 153 ELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDI 212

Query: 219 TKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLN 278
             G   GL+ LQEL L QN I  +SP  +     L  L L+ NH+S+L  S F+ L  LN
Sbjct: 213 PMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLN 272

Query: 279 TLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRI 338
            L +  N +  ++   F  + +L+ L L +N IS ++ D    FS L +L+ LIL  N+I
Sbjct: 273 RLTLFGNSLKELSLGIFGPMPNLRELWLYDNHIS-SLPD--NVFSNLRQLQVLILSRNQI 329

Query: 339 RSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 386
             I+  AF GL  L  L L  NA+  L GN F  +  LQ + L  + L
Sbjct: 330 SFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRL 377



 Score =  140 bits (352), Expect = 8e-33
 Identities = 112/381 (29%), Positives = 183/381 (48%), Gaps = 9/381 (2%)

Query: 9   SLCLLFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSL 68
           S C     S+ + +  R+  +      +  SL+ +  +  EL   P L  +SA I L  +
Sbjct: 27  SECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLN-ISALIAL-RI 84

Query: 69  AGNRIVEILPEHLKEFQSLETLDLSSNNISELQTA-FPALQ-LKYLYLNSNRVTSMEPGY 126
             N +  I P   +   SL  L L++N +  L    F  L  L+ L L+SN++  ++P +
Sbjct: 85  EKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAH 144

Query: 127 FDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLK 185
           F   +N L  L+L+ N +  IP   F  L  L  L L +N + ++    FQ LG L+ L+
Sbjct: 145 FSQCSN-LKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLR 203

Query: 186 MQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPD 245
           +  N +T +  G F GL N++ L L  N +  ++ G  +    LQ L+LS N I+++ P 
Sbjct: 204 LYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPS 263

Query: 246 AWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLD 305
            +    +L+ L L  N L  L    F  +  L  L + +N +S + D  F  L  L+ L 
Sbjct: 264 IFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLI 323

Query: 306 LKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSL 365
           L  N+IS+      GAF+GL +LR L L  N ++ +    F  L  L+++ L +N +  L
Sbjct: 324 LSRNQISFISP---GAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQL 380

Query: 366 QGNAFSQMKKLQQLHLNTSSL 386
            GN F+ +  L  + L  + L
Sbjct: 381 PGNIFANVNGLMAIQLQNNQL 401



 Score =  119 bits (297), Expect = 2e-26
 Identities = 108/345 (31%), Positives = 164/345 (47%), Gaps = 34/345 (9%)

Query: 21  LSHNRLSFIKASSMSHLQSLREVKLNNNELETIP-NLGPVSANITLLSLAGNRIVEILPE 79
           +  N LS I   +  +L SLR + L NN+L+ +P  L     ++  L L+ N++++I P 
Sbjct: 84  IEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPA 143

Query: 80  HLKEFQSLETLDLSSNNISELQT-AFPALQ-LKYLYLNSNRVTSMEPGYFDNLANTLLVL 137
           H  +  +L+ L L  N++  +   AF  L  L  L L  N +T + P  F +L N L VL
Sbjct: 144 HFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGN-LQVL 202

Query: 138 KLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMD 196
           +L  NR++ IP   F  L  LQ L L +N+I  +    F     L+ L +  N +++L  
Sbjct: 203 RLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPP 262

Query: 197 GAFWGLSNMEILQLDHNNLTEITKG-----------WLY-------------GLLMLQEL 232
             F  L  +  L L  N+L E++ G           WLY              L  LQ L
Sbjct: 263 SIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVL 322

Query: 233 HLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIAD 292
            LS+N I+ ISP A+    +L EL L  N L  LD + F  L+ L  + + NNR+  +  
Sbjct: 323 ILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPG 382

Query: 293 CAFRGLSSLKTLDLKNNEISWTIEDMN-GAFSGLDKLRRLILQGN 336
             F  ++ L  + L+NN+    +E++  G F  L KL  L L  N
Sbjct: 383 NIFANVNGLMAIQLQNNQ----LENLPLGIFDHLGKLCELRLYDN 423


>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
           sapiens]
          Length = 593

 Score =  155 bits (391), Expect = 2e-37
 Identities = 158/499 (31%), Positives = 240/499 (48%), Gaps = 37/499 (7%)

Query: 68  LAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQ--LKYLYLNSNRVTSMEPG 125
           L G+R +E +P  L      E LDLS N +  LQ    +    L+ L L+ N+++++EPG
Sbjct: 45  LCGHRQLEAVPGGLP--LDTELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPG 102

Query: 126 YFDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSL 184
            F  L  +LL L+L  NR+  + P +F  L  L  L+L  N+I       F  LG+L+ L
Sbjct: 103 AFHGL-QSLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKL 161

Query: 185 KMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISP 244
           ++  N +  +  GAF GL+ +  L L+  NL+ +    L  L  L  L L +  I R+  
Sbjct: 162 EVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPA 221

Query: 245 DAWEFCQKLSELDL-TFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKT 303
            A     +L EL++  +  L  LD  S +GL+L ++L I    +S +   A   LS L+ 
Sbjct: 222 GALRGLGQLKELEIHLWPSLEALDPGSLVGLNL-SSLAITRCNLSSVPFQALYHLSFLRV 280

Query: 304 LDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIM 363
           LDL  N IS          S L +L+ L L G  + SI   AF GL A   LD++DNA+ 
Sbjct: 281 LDLSQNPISAIPARR---LSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQ 337

Query: 364 SLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSI 423
           +L+  AF    KL  L L+ + L CDC+L WL +     +F      +CA P  ++G+S+
Sbjct: 338 TLEETAFPSPDKLVTLRLSGNPLTCDCRLLWLLRLRRHLDF-GMSPPACAGPHHVQGKSL 396

Query: 424 FAVS----PDGFVCDDFPKPQITVQ--PETQSAIKGSNLSFICSAASSSDSPMTFAWKKD 477
              S    P  F C    KP +  +  P    A +G +  F CS     D   T +W + 
Sbjct: 397 KEFSDILPPGHFTC----KPALIRKSGPRWVIAEEGGHAVFSCS--GDGDPAPTVSWMRP 450

Query: 478 NELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKL 537
               H A +     +R     V+E  T L +R V+    G Y CV+SN  G+  S++  L
Sbjct: 451 ----HGAWLGRAGRVR-----VLEDGT-LEIRSVQLRDRGAYVCVVSNVAGND-SLRTWL 499

Query: 538 TVNML--PSFTKTPMDLTI 554
            V  +  P+ T +  ++T+
Sbjct: 500 EVIQVEPPNGTLSDPNITV 518



 Score = 97.4 bits (241), Expect = 6e-20
 Identities = 93/298 (31%), Positives = 141/298 (47%), Gaps = 7/298 (2%)

Query: 20  DLSHNRLSFIKASSMSHLQSLREVKLNNNELETI-PNLGPVSANITLLSLAGNRIVEILP 78
           DLS NRL  ++   +S L  L+E+ L+ N+L T+ P       ++  L L GNR+  + P
Sbjct: 66  DLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGP 125

Query: 79  EHLKEFQSLETLDLSSNNI-SELQTAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLV 136
                  +L  LDL  N I   L  AF  L  L+ L +  N +  + PG F  LA  L  
Sbjct: 126 GVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAK-LST 184

Query: 137 LKLNRNRISAIPP-KMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLM 195
           L L R  +S +P   + +LP L  L L    I  +     +GLG LK L++      + +
Sbjct: 185 LTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEAL 244

Query: 196 D-GAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLS 254
           D G+  GL N+  L +   NL+ +    LY L  L+ L LSQN I+ I         +L 
Sbjct: 245 DPGSLVGL-NLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQ 303

Query: 255 ELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEIS 312
           EL L+   L+ +   +F GL+  + L + +N +  + + AF     L TL L  N ++
Sbjct: 304 ELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLT 361



 Score = 94.4 bits (233), Expect = 5e-19
 Identities = 125/478 (26%), Positives = 185/478 (38%), Gaps = 57/478 (11%)

Query: 206 EILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSR 265
           E+L L  N L  + +G L  L +LQEL LS N ++ + P A+   Q L  L L  N L  
Sbjct: 63  ELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRI 122

Query: 266 LDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGL 325
           +    F GLS L  L +  N++    D AF  L SL+ L++ +N + +      GAF+GL
Sbjct: 123 MGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAP---GAFAGL 179

Query: 326 DKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLH----- 380
            KL  L L+   + ++   A   L AL  L L +  I  L   A   + +L++L      
Sbjct: 180 AKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWP 239

Query: 381 ------------LNTSSL-LCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVS 427
                       LN SSL +  C L  +P       FQ+  + S      L    I A+ 
Sbjct: 240 SLEALDPGSLVGLNLSSLAITRCNLSSVP-------FQALYHLSFLRVLDLSQNPISAIP 292

Query: 428 PDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEM- 486
                      P + +Q   +  + G+ L+ I + A    +        DN L    E  
Sbjct: 293 ARRL------SPLVRLQ---ELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETA 343

Query: 487 ----ENYAHLRAQGGEVM---EYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTV 539
               +    LR  G  +        +LRLR           C   +H     S+K    +
Sbjct: 344 FPSPDKLVTLRLSGNPLTCDCRLLWLLRLRRHLDFGMSPPACAGPHHVQGK-SLKEFSDI 402

Query: 540 NMLPSFT--------KTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERR 591
                FT          P  +    G  A   C+  G PAP ++W +  G      R  R
Sbjct: 403 LPPGHFTCKPALIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVSWMRPHGAWL--GRAGR 460

Query: 592 MHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVT 649
           + V+ ED    I  V++ D G Y C   N AG+ S    L V++       L D  +T
Sbjct: 461 VRVL-EDGTLEIRSVQLRDRGAYVCVVSNVAGNDSLRTWLEVIQVEPPNGTLSDPNIT 517



 Score = 39.7 bits (91), Expect = 0.015
 Identities = 25/95 (26%), Positives = 36/95 (37%), Gaps = 4/95 (4%)

Query: 650 KGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEM 709
           +G  AV  C   G P P ++W +     +          +  L I    + D G Y C +
Sbjct: 427 EGGHAVFSCSGDGDPAPTVSWMRPHGAWLGRAGRVRVLEDGTLEIRSVQLRDRGAYVCVV 486

Query: 710 SNTLGTERGNVRLSVI----PTPTCDSPQMTAPSL 740
           SN  G +     L VI    P  T   P +T P +
Sbjct: 487 SNVAGNDSLRTWLEVIQVEPPNGTLSDPNITVPGI 521



 Score = 34.3 bits (77), Expect = 0.64
 Identities = 30/110 (27%), Positives = 53/110 (48%), Gaps = 5/110 (4%)

Query: 15  HISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIP--NLGPVSANITLLSLAGNR 72
           ++S   ++   LS +   ++ HL  LR + L+ N +  IP   L P+   +  L L+G  
Sbjct: 253 NLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPL-VRLQELRLSGAC 311

Query: 73  IVEILPEHLKEFQSLETLDLSSNNISEL-QTAFPAL-QLKYLYLNSNRVT 120
           +  I         +   LD++ N +  L +TAFP+  +L  L L+ N +T
Sbjct: 312 LTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLT 361


>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
           sapiens]
          Length = 606

 Score =  153 bits (387), Expect = 7e-37
 Identities = 154/525 (29%), Positives = 232/525 (44%), Gaps = 56/525 (10%)

Query: 41  REVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISEL 100
           + V  +   L  IP   P+   I  L L+ NR+  + PE    +  LE +DLS N I+  
Sbjct: 39  KSVSCHRRRLIAIPEGIPIETKI--LDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIA-- 94

Query: 101 QTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQH 159
                               ++EPG F+NL N L  L+L  NR+  +P  +F  L  L  
Sbjct: 95  --------------------NVEPGAFNNLFN-LRSLRLKGNRLKLVPLGVFTGLSNLTK 133

Query: 160 LELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEIT 219
           L+++ NKI  +    FQ L  LKSL++  N +  +   AF GL ++E L L+  NLT + 
Sbjct: 134 LDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVP 193

Query: 220 KGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTF-NHLSRLDDSSFLGLSLLN 278
              L  L  L  LHL    IN +   A++    L  L++ +   L  +  +S  GL+L  
Sbjct: 194 TEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNL-T 252

Query: 279 TLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRI 338
           +L + N  +S +   AF+ L  L  L+L  N IS TIE   G FS L +L+ L + G ++
Sbjct: 253 SLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPIS-TIEA--GMFSDLIRLQELHIVGAQL 309

Query: 339 RSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQW 398
           R+I   +F GL  L  L++S N + +L+ N FS  + L+ L +N + L CDC+L W+ Q 
Sbjct: 310 RTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLACDCRLLWILQR 369

Query: 399 VAENNFQSFVNASCAHPQLLKGRSIFAVSPDG----FVCDDFPKPQITVQPETQSAI-KG 453
                F       CA P  ++ RS            F C    KP+I  +      + +G
Sbjct: 370 QPTLQFGG-QQPMCAGPDTIRERSFKDFHSTALSFYFTC---KKPKIREKKLQHLLVDEG 425

Query: 454 SNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEF 513
             +   CSA    D     +W          +    A +   G         L +R  + 
Sbjct: 426 QTVQLECSA--DGDPQPVISWVTPRRRFITTKSNGRATVLGDG--------TLEIRFAQD 475

Query: 514 ASEGKYQCVISNHFGSSYSVKAKLTVNMLPS-----FTKTPMDLT 553
              G Y C+ SN  G+  +  A LTV    S       +TPM +T
Sbjct: 476 QDSGMYVCIASNAAGND-TFTASLTVKGFASDRFLYANRTPMYMT 519



 Score = 77.4 bits (189), Expect = 7e-14
 Identities = 77/305 (25%), Positives = 135/305 (44%), Gaps = 21/305 (6%)

Query: 20  DLSHNRLSFIKASSMSHLQSLREVKLNNNELETI-PNLGPVSANITLLSLAGNRIVEILP 78
           DLS NRL  +          L E+ L++N +  + P       N+  L L GNR+  +  
Sbjct: 63  DLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPL 122

Query: 79  EHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPG-----YFDNLANT 133
                  +L  LD+S N I         + L Y++ + + + S+E G     Y  + A +
Sbjct: 123 GVFTGLSNLTKLDISENKI--------VILLDYMFQDLHNLKSLEVGDNDLVYISHRAFS 174

Query: 134 LLV----LKLNRNRISAIPPK-MFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQR 188
            L+    L L +  ++A+P + +  L  L  L L    I N+    F+ L  LK L++  
Sbjct: 175 GLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDY 234

Query: 189 NGVTKLMD-GAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAW 247
             +  +M   + +GL N+  L + + NL+ +       L+ L  L+LS N I+ I    +
Sbjct: 235 WPLLDMMPANSLYGL-NLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMF 293

Query: 248 EFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLK 307
               +L EL +    L  ++  SF GL  L  L++  N +  + +  F    +L+ L + 
Sbjct: 294 SDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSIN 353

Query: 308 NNEIS 312
           NN ++
Sbjct: 354 NNPLA 358



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 57/235 (24%), Positives = 107/235 (45%), Gaps = 13/235 (5%)

Query: 13  LFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITL--LSLAG 70
           L ++++ D+S N++  +       L +L+ +++ +N+L  I +    S  ++L  L+L  
Sbjct: 128 LSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRA-FSGLLSLEQLTLEK 186

Query: 71  NRIVEILPEHLKEFQSLETLDLSSNNISELQT-AFPAL-QLKYLYLNSNRVTSMEPG--- 125
             +  +  E L   +SL +L L   NI+ +   AF  L  LK+L ++   +  M P    
Sbjct: 187 CNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSL 246

Query: 126 YFDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSL 184
           Y  NL +    L +    +S +P   FK L  L HL L+ N I  ++   F  L  L+ L
Sbjct: 247 YGLNLTS----LSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQEL 302

Query: 185 KMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAI 239
            +    +  +   +F GL  + +L +  N L  + +        L+ L ++ N +
Sbjct: 303 HIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPL 357



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 27/82 (32%), Positives = 39/82 (47%), Gaps = 1/82 (1%)

Query: 552 LTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDI 611
           L +  G   +LEC+A G P P I+W              R  V+  D    I   + +D 
Sbjct: 420 LLVDEGQTVQLECSADGDPQPVISWVTPRRRFITTKSNGRATVLG-DGTLEIRFAQDQDS 478

Query: 612 GVYSCTAQNSAGSISANATLTV 633
           G+Y C A N+AG+ +  A+LTV
Sbjct: 479 GMYVCIASNAAGNDTFTASLTV 500



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 24/79 (30%), Positives = 37/79 (46%), Gaps = 2/79 (2%)

Query: 648 VTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAA--GNQLLIIVDSDVSDAGKY 705
           V +G+T  L+C A G P P ++W       + T+ +  A   G+  L I  +   D+G Y
Sbjct: 422 VDEGQTVQLECSADGDPQPVISWVTPRRRFITTKSNGRATVLGDGTLEIRFAQDQDSGMY 481

Query: 706 TCEMSNTLGTERGNVRLSV 724
            C  SN  G +     L+V
Sbjct: 482 VCIASNAAGNDTFTASLTV 500


>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
           sapiens]
          Length = 592

 Score =  149 bits (375), Expect = 2e-35
 Identities = 148/514 (28%), Positives = 234/514 (45%), Gaps = 47/514 (9%)

Query: 41  REVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISEL 100
           R V      L  +P+   + A   LL L+ NRI  + P  L    +LE LDLS N I+ +
Sbjct: 36  RAVACTRRRLTAVPD--GIPAETRLLELSRNRIRCLNPGDLAALPALEELDLSENAIAHV 93

Query: 101 QTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMF-KLPQLQH 159
                                 EPG F NL   L VL+L  N++  IPP +F +L  L  
Sbjct: 94  ----------------------EPGAFANLPR-LRVLRLRGNQLKLIPPGVFTRLDNLTL 130

Query: 160 LELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEIT 219
           L+L+ NK+  +   TFQ L +L+ L++  N +  +   AF GL  +E L L+  NLT ++
Sbjct: 131 LDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALS 190

Query: 220 KGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDL-TFNHLSRLDDSSFLGLSLLN 278
              L  L  L  L L   AI  +    +     L  L++  +  L  +   S  GL+L  
Sbjct: 191 GESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGLNL-T 249

Query: 279 TLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRI 338
           +L + +  ++ +   A R  + L  L+L +N IS       G+F  L +LR L L G  +
Sbjct: 250 SLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTV---PRGSFRDLVRLRELHLAGALL 306

Query: 339 RSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQW 398
             +  +AF GL  +  L+LS+N + +L+ + F  +  L+ L ++ + L CDC+L W+ Q 
Sbjct: 307 AVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRLLWIVQR 366

Query: 399 VAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDF--PKPQITVQP-ETQSAIKGSN 455
               NF   + A CA P  ++G ++  + PD  + + F   KP+I  +  +  +A  G +
Sbjct: 367 RKTLNFDGRLPA-CATPAEVRGDALRNL-PDSVLFEYFVCRKPKIRERRLQRVTATAGED 424

Query: 456 LSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFAS 515
           + F+C A    +   T AW         A     A +   G         L +++     
Sbjct: 425 VRFLCRA--EGEPAPTVAWVTPQHRPVTATSAGRARVLPGG--------TLEIQDARPQD 474

Query: 516 EGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTP 549
            G Y CV SN  G + +  A LTV   P+  +TP
Sbjct: 475 SGTYTCVASN-AGGNDTYFATLTVRPEPAANRTP 507



 Score = 98.6 bits (244), Expect = 3e-20
 Identities = 79/279 (28%), Positives = 150/279 (53%), Gaps = 9/279 (3%)

Query: 20  DLSHNRLSFIKASSMSHLQSLREVKLNNNELETI-PNLGPVSANITLLSLAGNRIVEILP 78
           DLS N ++ ++  + ++L  LR ++L  N+L+ I P +     N+TLL L+ N++V +L 
Sbjct: 84  DLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVILLD 143

Query: 79  EHLKEFQSLETLDLSSNNISEL-QTAFPA-LQLKYLYLNSNRVTSMEPGYFDNLANTLLV 136
              ++  SL  L++  N++  + + AF   L L+ L L    +T++      +L  +L  
Sbjct: 144 YTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHL-RSLGA 202

Query: 137 LKLNRNRISAIPPKMF-KLPQLQHLEL-NRNKIKNVDGLTFQGLGALKSLKMQRNGVTKL 194
           L+L    I+++  + F +LP L HLE+ N   ++ V   + +GL  L SL +    +T +
Sbjct: 203 LRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGLN-LTSLSVTHTNITAV 261

Query: 195 MDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLS 254
              A    +++  L L HN ++ + +G    L+ L+ELHL+   +  + P A+   +++ 
Sbjct: 262 PAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIR 321

Query: 255 ELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADC 293
            L+L+ N LS L++S+F  ++ L TL +  N ++   DC
Sbjct: 322 LLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLA--CDC 358



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 31/87 (35%), Positives = 41/87 (47%), Gaps = 1/87 (1%)

Query: 552 LTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDI 611
           +T  AG   R  C A G PAP +AW         A    R  V+P      I D + +D 
Sbjct: 417 VTATAGEDVRFLCRAEGEPAPTVAWVTPQHRPVTATSAGRARVLP-GGTLEIQDARPQDS 475

Query: 612 GVYSCTAQNSAGSISANATLTVLETPS 638
           G Y+C A N+ G+ +  ATLTV   P+
Sbjct: 476 GTYTCVASNAGGNDTYFATLTVRPEPA 502



 Score = 40.0 bits (92), Expect = 0.012
 Identities = 30/88 (34%), Positives = 37/88 (42%), Gaps = 4/88 (4%)

Query: 647 TVTKGETAVLQCIAGGSPPPKLNW-TKDDSPLVVTE--RHFFAAGNQLLIIVDSDVSDAG 703
           T T GE     C A G P P + W T    P+  T   R     G  L I  D+   D+G
Sbjct: 418 TATAGEDVRFLCRAEGEPAPTVAWVTPQHRPVTATSAGRARVLPGGTLEI-QDARPQDSG 476

Query: 704 KYTCEMSNTLGTERGNVRLSVIPTPTCD 731
            YTC  SN  G +     L+V P P  +
Sbjct: 477 TYTCVASNAGGNDTYFATLTVRPEPAAN 504



 Score = 32.3 bits (72), Expect = 2.4
 Identities = 24/85 (28%), Positives = 39/85 (45%), Gaps = 1/85 (1%)

Query: 15  HISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETI-PNLGPVSANITLLSLAGNRI 73
           H++  +LSHN +S +   S   L  LRE+ L    L  + P        I LL+L+ N +
Sbjct: 271 HLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLL 330

Query: 74  VEILPEHLKEFQSLETLDLSSNNIS 98
             +         +LETL +  N ++
Sbjct: 331 STLEESTFHSVNTLETLRVDGNPLA 355


>gi|198041768 synleurin [Homo sapiens]
          Length = 622

 Score =  147 bits (370), Expect = 7e-35
 Identities = 124/397 (31%), Positives = 190/397 (47%), Gaps = 38/397 (9%)

Query: 32  SSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLD 91
           SS+  L + R++   N  L +IP   P S     L L GN I  I    L    SL  L 
Sbjct: 33  SSVCQLCTGRQINCRNLGLSSIPKNFPEST--VFLYLTGNNISYINESELTGLHSLVALY 90

Query: 92  LSSNNISEL-QTAFPALQ-LKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPP 149
           L ++NI  +   AF  L+ L +L+LN+N +  ++PG F  L N L  L L  N++S +P 
Sbjct: 91  LDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLN-LRNLYLQYNQVSFVPR 149

Query: 150 KMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEIL 208
            +F  L  +Q+L L RN++  +   TF G+ AL+ L +  N + ++ +  F  L N+  L
Sbjct: 150 GVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACL 209

Query: 209 QLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDD 268
            L  NNLT++       L  L+ L LS N I  I P A                      
Sbjct: 210 YLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFA---------------------- 247

Query: 269 SSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNG-AFSGLDK 327
             F GL+ L  L + N+R+  +    F G+++LK L L +N+    +E++N   FS L  
Sbjct: 248 --FKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHND----LENLNSDTFSLLKN 301

Query: 328 LRRLILQGNRIRSITKKAFTGLDA-LEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 386
           L  L L  NRI SI    F  + A L+ L+LS N + +L       +  L  L  N++  
Sbjct: 302 LIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNPW 361

Query: 387 LCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSI 423
            C+C+L  L  W+A +     +N  C +P  ++GR++
Sbjct: 362 ECNCKLLGLRDWLASSAIT--LNIYCQNPPSMRGRAL 396



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 61/199 (30%), Positives = 101/199 (50%), Gaps = 6/199 (3%)

Query: 20  DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLG-PVSANITLLSLAGNRIVEILP 78
           +L  NRL+ + + +   + +LR + L+NN +  I   G     N+  L L  N + ++  
Sbjct: 162 NLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPS 221

Query: 79  EHLKEFQSLETLDLSSNNISELQT-AFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLV 136
              +  +SL  L LS N I  +Q  AF  L  L+YL L ++R+ ++    F  + N L  
Sbjct: 222 NAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGI-NNLKH 280

Query: 137 LKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGA-LKSLKMQRNGVTKL 194
           L L+ N +  +    F  L  L +L+L+RN+I ++D  TF+ +GA LK L +  N +T L
Sbjct: 281 LILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTAL 340

Query: 195 MDGAFWGLSNMEILQLDHN 213
                  LS++  LQ + N
Sbjct: 341 HPRVLKPLSSLIHLQANSN 359


>gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
          Length = 620

 Score =  145 bits (366), Expect = 2e-34
 Identities = 141/466 (30%), Positives = 225/466 (48%), Gaps = 43/466 (9%)

Query: 90  LDLSSNNISELQ----TAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRIS 145
           LDL  N I  L      +FP   L+ L LN N V+++EPG F+NL N L  L L  NR+ 
Sbjct: 76  LDLGKNRIKTLNQDEFASFP--HLEELELNENIVSAVEPGAFNNLFN-LRTLGLRSNRLK 132

Query: 146 AIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSN 204
            IP  +F  L  L  L+++ NKI  +    FQ L  LKSL++  N +  +   AF GL++
Sbjct: 133 LIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNS 192

Query: 205 MEILQLDHNNLTEITK---GWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLT-F 260
           +E L L+  NLT I       L+GL++L+  HL+ NAI   S   ++   +L  L+++ +
Sbjct: 193 LEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYS---FKRLYRLKVLEISHW 249

Query: 261 NHLSRLDDSSFLGLSL--LNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDM 318
            +L  +  +   GL+L  L+  H     V Y+A    R L  L+ L+L  N IS TIE  
Sbjct: 250 PYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLA---VRHLVYLRFLNLSYNPIS-TIE-- 303

Query: 319 NGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQ 378
                 L +L+ + L G ++  +   AF GL+ L  L++S N + +L+ + F  +  L+ 
Sbjct: 304 GSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLET 363

Query: 379 LHLNTSSLLCDCQLKWL--PQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDF 436
           L L+++ L CDC+L W+   +W    N Q     +CA P+ ++G+  F   PD  + + F
Sbjct: 364 LILDSNPLACDCRLLWVFRRRWRLNFNRQ---QPTCATPEFVQGKE-FKDFPDVLLPNYF 419

Query: 437 PKPQITVQPETQSAI---KGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLR 493
              +  ++      +   +G  + F+C A    D P    W    + L  A+      + 
Sbjct: 420 TCRRARIRDRKAQQVFVDEGHTVQFVCRA--DGDPPPAILWLSPRKHLVSAKSNGRLTVF 477

Query: 494 AQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTV 539
             G         L +R  +    G Y C+ +N  G + S+ A L V
Sbjct: 478 PDG--------TLEVRYAQVQDNGTYLCIAAN-AGGNDSMPAHLHV 514



 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 77/302 (25%), Positives = 149/302 (49%), Gaps = 29/302 (9%)

Query: 15  HISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS--ANITLLSLAGNR 72
           H+   +L+ N +S ++  + ++L +LR + L +N L+ IP LG  +  +N+T L ++ N+
Sbjct: 96  HLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIP-LGVFTGLSNLTKLDISENK 154

Query: 73  IVEILPEHLKEFQSLETLDLSSNNISEL-QTAFPAL-QLKYLYLNSNRVTSMEPGYFDNL 130
           IV +L    ++  +L++L++  N++  +   AF  L  L+ L L    +TS+      +L
Sbjct: 155 IVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHL 214

Query: 131 ANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNG 190
            + L+VL+L    I+AI    FK        L R K+  +    +               
Sbjct: 215 -HGLIVLRLRHLNINAIRDYSFK-------RLYRLKVLEISHWPY--------------- 251

Query: 191 VTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFC 250
           +  +     +GL N+  L + H NLT +    +  L+ L+ L+LS N I+ I        
Sbjct: 252 LDTMTPNCLYGL-NLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHEL 310

Query: 251 QKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNE 310
            +L E+ L    L+ ++  +F GL+ L  L++  N+++ + +  F  + +L+TL L +N 
Sbjct: 311 LRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNP 370

Query: 311 IS 312
           ++
Sbjct: 371 LA 372



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 105/470 (22%), Positives = 176/470 (37%), Gaps = 73/470 (15%)

Query: 207 ILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRL 266
           +L L  N +  + +        L+EL L++N ++ + P A+     L  L L  N L  +
Sbjct: 75  LLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLI 134

Query: 267 DDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLD 326
               F GLS L  L I  N++  + D  F+ L +LK+L++ +N++ +     + AFSGL+
Sbjct: 135 PLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYI---SHRAFSGLN 191

Query: 327 KLRRLILQGNRIRSITKKAFT---GLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLH--- 380
            L +L L+   + SI  +A +   GL  L    L+ NAI         ++K L+  H   
Sbjct: 192 SLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPY 251

Query: 381 -----------LNTSSL-LCDCQLKWLPQWVAEN-----------NFQSFVNASCAHPQL 417
                      LN +SL +  C L  +P     +           N  S +  S  H  L
Sbjct: 252 LDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELL 311

Query: 418 ------LKGRSIFAVSPDGF-------VCDDFPKPQITVQPETQSAIKGSNLSFICSAAS 464
                 L G  +  V P  F       V +       T++     ++       + S   
Sbjct: 312 RLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPL 371

Query: 465 SSDSPMTFAWKKDNELLHDAEMENYAHLR-AQGGEVMEYTTILRLREVEFASEGKYQCVI 523
           + D  + + +++   L  + +    A     QG E  ++  +L                +
Sbjct: 372 ACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVL----------------L 415

Query: 524 SNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTD 583
            N+F          T        +    + +  G   +  C A G P P I W       
Sbjct: 416 PNYF----------TCRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHL 465

Query: 584 FPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTV 633
             A    R+ V P D    +   +++D G Y C A N+ G+ S  A L V
Sbjct: 466 VSAKSNGRLTVFP-DGTLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHV 514



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 58/230 (25%), Positives = 101/230 (43%), Gaps = 27/230 (11%)

Query: 13  LFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSAN-ITLLSLAGN 71
           L ++++ D+S N++  +       L +L+ +++ +N+L  I +      N +  L+L   
Sbjct: 142 LSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKC 201

Query: 72  RIVEILPEHLKEFQSLETLDLSSNNISELQT-AFPAL-QLKYLYLNS-NRVTSMEPGYFD 128
            +  I  E L     L  L L   NI+ ++  +F  L +LK L ++    + +M P    
Sbjct: 202 NLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLY 261

Query: 129 NLANT----------------------LLVLKLNRNRISAIPPKMF-KLPQLQHLELNRN 165
            L  T                      L  L L+ N IS I   M  +L +LQ ++L   
Sbjct: 262 GLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGG 321

Query: 166 KIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNL 215
           ++  V+   F+GL  L+ L +  N +T L +  F  + N+E L LD N L
Sbjct: 322 QLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPL 371



 Score = 36.2 bits (82), Expect = 0.17
 Identities = 18/58 (31%), Positives = 34/58 (58%)

Query: 329 RRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 386
           R L L  NRI+++ +  F     LE L+L++N + +++  AF+ +  L+ L L ++ L
Sbjct: 74  RLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRL 131



 Score = 32.3 bits (72), Expect = 2.4
 Identities = 24/81 (29%), Positives = 32/81 (39%), Gaps = 6/81 (7%)

Query: 648 VTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERH----FFAAGNQLLIIVDSDVSDAG 703
           V +G T    C A G PPP + W      LV  + +     F  G   L +  + V D G
Sbjct: 436 VDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDGT--LEVRYAQVQDNG 493

Query: 704 KYTCEMSNTLGTERGNVRLSV 724
            Y C  +N  G +     L V
Sbjct: 494 TYLCIAANAGGNDSMPAHLHV 514


>gi|225579152 insulin-like growth factor binding protein, acid
           labile subunit isoform 1 precursor [Homo sapiens]
          Length = 643

 Score =  141 bits (355), Expect = 4e-33
 Identities = 126/442 (28%), Positives = 201/442 (45%), Gaps = 54/442 (12%)

Query: 21  LSHNRLSFIKASSMSHLQSLREVKLNNNELETIP-------------NLG-------PVS 60
           L  N+L  +   + +H  +L  + L+NN L  +              NLG       P +
Sbjct: 167 LERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDA 226

Query: 61  A-----NITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQ-TAFPAL-QLKYLY 113
           A     ++  L LAGNR+  + P        L  LDLS N +  ++   F  L +L+ LY
Sbjct: 227 AFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLY 286

Query: 114 LNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDG 172
           L+ N + ++ PG F  L   L  L L+ NR++ +    F  L  L+ L L+ N I ++  
Sbjct: 287 LDRNLIAAVAPGAFLGL-KALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRP 345

Query: 173 LTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQEL 232
            TF+ L  L+ L++  N + +L + +F GL  +E+L LDHN L E+  G   GL  +  +
Sbjct: 346 RTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVM 405

Query: 233 HLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIAD 292
           +LS N +  +    +    KL  L L  + L R+   +F GLS L  L + +N +  I +
Sbjct: 406 NLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEE 465

Query: 293 CAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDAL 352
            +  GL+ L  LDL +N+++     +   F GL KL  L+L  NR+  +   A   L   
Sbjct: 466 QSLWGLAELLELDLTSNQLTHLPHRL---FQGLGKLEYLLLSRNRLAELPADALGPLQRA 522

Query: 353 EHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLL--------------------CDCQL 392
             LD+S N + +L  +  + + +L+ L L  +SL                     C C L
Sbjct: 523 FWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPL 582

Query: 393 KWLPQWVAEN--NFQSFVNASC 412
           K L  +  +N      FV A C
Sbjct: 583 KALRDFALQNPSAVPRFVQAIC 604



 Score =  134 bits (337), Expect = 5e-31
 Identities = 97/295 (32%), Positives = 155/295 (52%), Gaps = 6/295 (2%)

Query: 93  SSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPK-M 151
           SS N++ L    P    + L+L+ N ++S+ P  F NL++ L  L L   ++ ++ P+ +
Sbjct: 99  SSRNLTRLPDGVPG-GTQALWLDGNNLSSVPPAAFQNLSS-LGFLNLQGGQLGSLEPQAL 156

Query: 152 FKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLD 211
             L  L HL L RN+++++   TF    AL SL +  N +++L DG F GL ++  L L 
Sbjct: 157 LGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLG 216

Query: 212 HNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSF 271
            N+L  +      GL  L+EL L+ N +  + P  +    +L ELDL+ N L  +  + F
Sbjct: 217 WNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVF 276

Query: 272 LGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRL 331
           + L  L  L++  N ++ +A  AF GL +L+ LDL +N ++  +ED    F GL  LR L
Sbjct: 277 VQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLED---TFPGLLGLRVL 333

Query: 332 ILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 386
            L  N I S+  + F  L  LE L L  N I  L   +F  + +L+ L L+ + L
Sbjct: 334 RLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQL 388



 Score = 97.1 bits (240), Expect = 8e-20
 Identities = 79/269 (29%), Positives = 127/269 (47%), Gaps = 27/269 (10%)

Query: 20  DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPE 79
           DLSHNR++ +   +   L  LR                       +L L+ N I  + P 
Sbjct: 310 DLSHNRVAGLLEDTFPGLLGLR-----------------------VLRLSHNAIASLRPR 346

Query: 80  HLKEFQSLETLDLSSNNISEL-QTAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVL 137
             K+   LE L L  N I +L + +F  L QL+ L L+ N++  ++ G F  L N + V+
Sbjct: 347 TFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTN-VAVM 405

Query: 138 KLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMD 196
            L+ N +  +P ++F+ L +L  L L  + +  +   TF GL  L+ L ++ NG+  + +
Sbjct: 406 NLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEE 465

Query: 197 GAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSEL 256
            + WGL+ +  L L  N LT +      GL  L+ L LS+N +  +  DA    Q+   L
Sbjct: 466 QSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWL 525

Query: 257 DLTFNHLSRLDDSSFLGLSLLNTLHIGNN 285
           D++ N L  L +S    L  L  L + NN
Sbjct: 526 DVSHNRLEALPNSLLAPLGRLRYLSLRNN 554



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 55/237 (23%), Positives = 100/237 (42%), Gaps = 31/237 (13%)

Query: 13  LFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPN---LGPVSANITLLSLA 69
           L  +    L HNR+  +   S   L  L  + L++N+L+ +     LG    N+ +++L+
Sbjct: 351 LHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLG--LTNVAVMNLS 408

Query: 70  GNRIVEILPEHLKEFQSLETLDLSSNNISELQT-AFPALQ-LKYLYLNSNRVTSMEPGYF 127
           GN +  +  +  +    L +L L  + +  ++   F  L  L+ L+L  N +  +E    
Sbjct: 409 GNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIE---- 464

Query: 128 DNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQ 187
                                  ++ L +L  L+L  N++ ++    FQGLG L+ L + 
Sbjct: 465 --------------------EQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLS 504

Query: 188 RNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISP 244
           RN + +L   A   L     L + HN L  +    L  L  L+ L L  N++   +P
Sbjct: 505 RNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTP 561



 Score = 32.0 bits (71), Expect = 3.2
 Identities = 20/52 (38%), Positives = 26/52 (50%), Gaps = 3/52 (5%)

Query: 20  DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGN 71
           D+SHNRL  +  S ++ L  LR + L NN L T     P    +  L L GN
Sbjct: 526 DVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFT---PQPPGLERLWLEGN 574


>gi|4826772 insulin-like growth factor binding protein, acid labile
           subunit isoform 2 precursor [Homo sapiens]
          Length = 605

 Score =  141 bits (355), Expect = 4e-33
 Identities = 126/442 (28%), Positives = 201/442 (45%), Gaps = 54/442 (12%)

Query: 21  LSHNRLSFIKASSMSHLQSLREVKLNNNELETIP-------------NLG-------PVS 60
           L  N+L  +   + +H  +L  + L+NN L  +              NLG       P +
Sbjct: 129 LERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDA 188

Query: 61  A-----NITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQ-TAFPAL-QLKYLY 113
           A     ++  L LAGNR+  + P        L  LDLS N +  ++   F  L +L+ LY
Sbjct: 189 AFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLY 248

Query: 114 LNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDG 172
           L+ N + ++ PG F  L   L  L L+ NR++ +    F  L  L+ L L+ N I ++  
Sbjct: 249 LDRNLIAAVAPGAFLGL-KALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRP 307

Query: 173 LTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQEL 232
            TF+ L  L+ L++  N + +L + +F GL  +E+L LDHN L E+  G   GL  +  +
Sbjct: 308 RTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVM 367

Query: 233 HLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIAD 292
           +LS N +  +    +    KL  L L  + L R+   +F GLS L  L + +N +  I +
Sbjct: 368 NLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEE 427

Query: 293 CAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDAL 352
            +  GL+ L  LDL +N+++     +   F GL KL  L+L  NR+  +   A   L   
Sbjct: 428 QSLWGLAELLELDLTSNQLTHLPHRL---FQGLGKLEYLLLSRNRLAELPADALGPLQRA 484

Query: 353 EHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLL--------------------CDCQL 392
             LD+S N + +L  +  + + +L+ L L  +SL                     C C L
Sbjct: 485 FWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPL 544

Query: 393 KWLPQWVAEN--NFQSFVNASC 412
           K L  +  +N      FV A C
Sbjct: 545 KALRDFALQNPSAVPRFVQAIC 566



 Score =  134 bits (337), Expect = 5e-31
 Identities = 97/295 (32%), Positives = 155/295 (52%), Gaps = 6/295 (2%)

Query: 93  SSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPK-M 151
           SS N++ L    P    + L+L+ N ++S+ P  F NL++ L  L L   ++ ++ P+ +
Sbjct: 61  SSRNLTRLPDGVPG-GTQALWLDGNNLSSVPPAAFQNLSS-LGFLNLQGGQLGSLEPQAL 118

Query: 152 FKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLD 211
             L  L HL L RN+++++   TF    AL SL +  N +++L DG F GL ++  L L 
Sbjct: 119 LGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLG 178

Query: 212 HNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSF 271
            N+L  +      GL  L+EL L+ N +  + P  +    +L ELDL+ N L  +  + F
Sbjct: 179 WNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVF 238

Query: 272 LGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRL 331
           + L  L  L++  N ++ +A  AF GL +L+ LDL +N ++  +ED    F GL  LR L
Sbjct: 239 VQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLED---TFPGLLGLRVL 295

Query: 332 ILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 386
            L  N I S+  + F  L  LE L L  N I  L   +F  + +L+ L L+ + L
Sbjct: 296 RLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQL 350



 Score = 97.1 bits (240), Expect = 8e-20
 Identities = 79/269 (29%), Positives = 127/269 (47%), Gaps = 27/269 (10%)

Query: 20  DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPE 79
           DLSHNR++ +   +   L  LR                       +L L+ N I  + P 
Sbjct: 272 DLSHNRVAGLLEDTFPGLLGLR-----------------------VLRLSHNAIASLRPR 308

Query: 80  HLKEFQSLETLDLSSNNISEL-QTAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVL 137
             K+   LE L L  N I +L + +F  L QL+ L L+ N++  ++ G F  L N + V+
Sbjct: 309 TFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTN-VAVM 367

Query: 138 KLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMD 196
            L+ N +  +P ++F+ L +L  L L  + +  +   TF GL  L+ L ++ NG+  + +
Sbjct: 368 NLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEE 427

Query: 197 GAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSEL 256
            + WGL+ +  L L  N LT +      GL  L+ L LS+N +  +  DA    Q+   L
Sbjct: 428 QSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWL 487

Query: 257 DLTFNHLSRLDDSSFLGLSLLNTLHIGNN 285
           D++ N L  L +S    L  L  L + NN
Sbjct: 488 DVSHNRLEALPNSLLAPLGRLRYLSLRNN 516



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 55/237 (23%), Positives = 100/237 (42%), Gaps = 31/237 (13%)

Query: 13  LFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPN---LGPVSANITLLSLA 69
           L  +    L HNR+  +   S   L  L  + L++N+L+ +     LG    N+ +++L+
Sbjct: 313 LHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLG--LTNVAVMNLS 370

Query: 70  GNRIVEILPEHLKEFQSLETLDLSSNNISELQT-AFPALQ-LKYLYLNSNRVTSMEPGYF 127
           GN +  +  +  +    L +L L  + +  ++   F  L  L+ L+L  N +  +E    
Sbjct: 371 GNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIE---- 426

Query: 128 DNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQ 187
                                  ++ L +L  L+L  N++ ++    FQGLG L+ L + 
Sbjct: 427 --------------------EQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLS 466

Query: 188 RNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISP 244
           RN + +L   A   L     L + HN L  +    L  L  L+ L L  N++   +P
Sbjct: 467 RNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTP 523



 Score = 32.0 bits (71), Expect = 3.2
 Identities = 20/52 (38%), Positives = 26/52 (50%), Gaps = 3/52 (5%)

Query: 20  DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGN 71
           D+SHNRL  +  S ++ L  LR + L NN L T     P    +  L L GN
Sbjct: 488 DVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFT---PQPPGLERLWLEGN 536


>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
          Length = 545

 Score =  135 bits (339), Expect = 3e-31
 Identities = 108/376 (28%), Positives = 180/376 (47%), Gaps = 8/376 (2%)

Query: 62  NITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQT-AFPAL-QLKYLYLNSNRV 119
           N+T +     ++ +  P+       LE L+++ ++   L T  F  L  L  L LN N +
Sbjct: 74  NLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNML 133

Query: 120 TSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGL 178
            ++  G F +LA  L  L L  N++ A+P ++F+ L  L+ L L +N +  +    F  L
Sbjct: 134 EALPEGLFQHLA-ALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPL 192

Query: 179 GALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNA 238
            +L++LK+  N ++ L  G F  L +++ L LD NN++E+       L  L+ L L +NA
Sbjct: 193 TSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNA 252

Query: 239 INRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGL 298
           I  +    +     L+ L L +N L  L    F     L  L + +N++  +A+  F  L
Sbjct: 253 ITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHL 312

Query: 299 SSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLS 358
           S+L++L L  N I+       G F  L++L +L L  N + ++    F  L  LE L LS
Sbjct: 313 SNLRSLMLSYNAITHLPA---GIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLS 369

Query: 359 DNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSF-VNASCAHPQL 417
            N + +L    F     L  L L+ +   CDC L +L  W+ +   +   +   CA P  
Sbjct: 370 KNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQTYCAGPAY 429

Query: 418 LKGRSIFAVSPDGFVC 433
           LKG+ + A++    VC
Sbjct: 430 LKGQVVPALNEKQLVC 445



 Score =  103 bits (257), Expect = 9e-22
 Identities = 95/297 (31%), Positives = 149/297 (50%), Gaps = 9/297 (3%)

Query: 20  DLSHNRLSFIKASS--MSHLQSLREVKLNNNELETIPN-LGPVSANITLLSLAGNRIVEI 76
           DL     SF+  S+   S+L SL ++ LN N LE +P  L    A +  L L GN++ + 
Sbjct: 101 DLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQL-QA 159

Query: 77  LPEHL-KEFQSLETLDLSSNNISEL--QTAFPALQLKYLYLNSNRVTSMEPGYFDNLANT 133
           LP  L +    L+TL+L+ N +++L  +   P   L+ L L++N ++ +  G F  L + 
Sbjct: 160 LPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGS- 218

Query: 134 LLVLKLNRNRISAIPPKMF-KLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVT 192
           L  L L+ N IS +PP++F +L  L+ L L RN I ++    F  LG L  L +Q N + 
Sbjct: 219 LQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLR 278

Query: 193 KLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQK 252
            L  G F     +  L L HN L  + +G    L  L+ L LS NAI  +    +   ++
Sbjct: 279 VLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEE 338

Query: 253 LSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNN 309
           L +L L  N+L+ L  + F  LS L  L +  N+++ + +  F    +L  L L  N
Sbjct: 339 LVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGN 395



 Score = 97.8 bits (242), Expect = 5e-20
 Identities = 82/277 (29%), Positives = 130/277 (46%), Gaps = 6/277 (2%)

Query: 13  LFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIP-NLGPVSANITLLSLAGN 71
           L  + +  L+ N L  +      HL +L  + L  N+L+ +P  L     ++  L+LA N
Sbjct: 120 LTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQN 179

Query: 72  RIVEILPEHLKEFQSLETLDLSSNNISEL-QTAFPAL-QLKYLYLNSNRVTSMEPGYFDN 129
            + ++  E      SL+TL LS+N +S L Q  F  L  L+ L+L+SN ++ + P  F  
Sbjct: 180 LLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQ 239

Query: 130 LANTLLVLKLNRNRISAIPPKMF-KLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQR 188
           L   L  L L RN I+ +P  +F  L  L  L L  N ++ +    F     L  L +  
Sbjct: 240 LF-CLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTH 298

Query: 189 NGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWE 248
           N +  + +G F  LSN+  L L +N +T +  G    L  L +L+L  N +  + P  ++
Sbjct: 299 NQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQ 358

Query: 249 FCQKLSELDLTFNHLSRLDDSSF-LGLSLLNTLHIGN 284
              KL  L L+ N L+ L +  F    +L N    GN
Sbjct: 359 NLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGN 395



 Score = 71.6 bits (174), Expect = 4e-12
 Identities = 54/205 (26%), Positives = 96/205 (46%), Gaps = 3/205 (1%)

Query: 182 KSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINR 241
           K++       T L   AF    N+  +   +  L +       GL  L++L ++ ++   
Sbjct: 52  KNIIFVETSFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLN 111

Query: 242 ISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSL 301
           +S + +     L +L L FN L  L +  F  L+ L +LH+  N++  +    F+ L+ L
Sbjct: 112 LSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHL 171

Query: 302 KTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNA 361
           KTL+L  N ++   E++   F  L  L+ L L  N +  + +  F  L +L+ L L  N 
Sbjct: 172 KTLNLAQNLLAQLPEEL---FHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNN 228

Query: 362 IMSLQGNAFSQMKKLQQLHLNTSSL 386
           I  L    FSQ+  L++L L  +++
Sbjct: 229 ISELPPQVFSQLFCLERLWLQRNAI 253


>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
          Length = 713

 Score =  133 bits (335), Expect = 8e-31
 Identities = 107/378 (28%), Positives = 171/378 (45%), Gaps = 35/378 (9%)

Query: 184 LKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRIS 243
           L +Q NG+  +    F  L ++EILQL  N + +I  G   GL  L  L L  N +  + 
Sbjct: 91  LNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVP 150

Query: 244 PDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGN-NRVSYIADCAFRGLSSLK 302
             A+E+  KL EL L  N +  +   +F  +  L  L +G   R+ YI++ AF GL +L+
Sbjct: 151 TQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLR 210

Query: 303 TL--------DLKNNEISWTIEDMN-----------GAFSGLDKLRRLILQGNRIRSITK 343
            L        D+ N      +E++            G+F GL  LR+L L   ++ +I +
Sbjct: 211 YLNLGMCNLKDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIER 270

Query: 344 KAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAEN- 402
            AF  L +LE L+LS N +MSL  + F+ + +L+++HLN +   C+C + WL  W+ E  
Sbjct: 271 NAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLKETV 330

Query: 403 NFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSA 462
              +   A C  P  LKGR I  +    F C     P I   P   +  +G      C  
Sbjct: 331 PSNTTCCARCHAPAGLKGRYIGELDQSHFTC---YAPVIVEPPTDLNVTEGMAAELKCRT 387

Query: 463 ASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCV 522
            +S  S         N L  +  +  +   R +   + + T  L    V     G+Y C+
Sbjct: 388 GTSMTSV--------NWLTPNGTLMTHGSYRVRISVLHDGT--LNFTNVTVQDTGQYTCM 437

Query: 523 ISNHFGSSYSVKAKLTVN 540
           ++N  G++ +  A L V+
Sbjct: 438 VTNSAGNT-TASATLNVS 454



 Score = 67.4 bits (163), Expect = 7e-11
 Identities = 61/223 (27%), Positives = 105/223 (47%), Gaps = 8/223 (3%)

Query: 20  DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSA--NITLLSLAGNRIVEIL 77
           +L  N +  I+  +  HL+ L  ++L+ N +  I  +G  +   ++  L L  NR+  + 
Sbjct: 92  NLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKI-EVGAFNGLPSLNTLELFDNRLTTVP 150

Query: 78  PEHLKEFQSLETLDLSSNNISELQT-AFPAL-QLKYLYLNS-NRVTSMEPGYFDNLANTL 134
            +  +    L  L L +N I  + + AF  +  L+ L L    R+  +    F+ L N L
Sbjct: 151 TQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVN-L 209

Query: 135 LVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKL 194
             L L    +  IP  +  L +L+ LEL+ N++  +   +FQGL +L+ L +    V  +
Sbjct: 210 RYLNLGMCNLKDIP-NLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATI 268

Query: 195 MDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQN 237
              AF  L ++E L L HNNL  +       L  L+ +HL+ N
Sbjct: 269 ERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHN 311



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 28/91 (30%), Positives = 40/91 (43%), Gaps = 1/91 (1%)

Query: 543 PSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFF 602
           P   + P DL +  G  A L+C   G     + W    GT       R    +  D    
Sbjct: 364 PVIVEPPTDLNVTEGMAAELKCRT-GTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGTLN 422

Query: 603 IVDVKIEDIGVYSCTAQNSAGSISANATLTV 633
             +V ++D G Y+C   NSAG+ +A+ATL V
Sbjct: 423 FTNVTVQDTGQYTCMVTNSAGNTTASATLNV 453



 Score = 37.4 bits (85), Expect = 0.075
 Identities = 25/91 (27%), Positives = 40/91 (43%), Gaps = 4/91 (4%)

Query: 637 PSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERH---FFAAGNQLLI 693
           P  + P  D  VT+G  A L+C  G S    +NW   +  L+    +        +  L 
Sbjct: 364 PVIVEPPTDLNVTEGMAAELKCRTGTSMT-SVNWLTPNGTLMTHGSYRVRISVLHDGTLN 422

Query: 694 IVDSDVSDAGKYTCEMSNTLGTERGNVRLSV 724
             +  V D G+YTC ++N+ G    +  L+V
Sbjct: 423 FTNVTVQDTGQYTCMVTNSAGNTTASATLNV 453



 Score = 33.5 bits (75), Expect = 1.1
 Identities = 30/111 (27%), Positives = 47/111 (42%), Gaps = 25/111 (22%)

Query: 9   SLCLLFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSL 68
           +L  L  +   +LS NRL  I+  S   L SLR++ L + ++ TI               
Sbjct: 224 NLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIER------------- 270

Query: 69  AGNRIVEILPEHLKEFQSLETLDLSSNNISEL--QTAFPALQLKYLYLNSN 117
                         + +SLE L+LS NN+  L      P  +L+ ++LN N
Sbjct: 271 ----------NAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHN 311


>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
          Length = 811

 Score =  131 bits (330), Expect = 3e-30
 Identities = 115/396 (29%), Positives = 185/396 (46%), Gaps = 20/396 (5%)

Query: 68  LAGNRIVEILPE--HLKEFQSLETLDLSSNNISELQTAFPAL---QLKYLYLNSNRVTSM 122
           L  NR + ++P+   L     + T  L  N I+ + TAF      QL+ L L  N++ S+
Sbjct: 40  LCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNI-TAFDFHRLGQLRRLDLQYNQIRSL 98

Query: 123 EPGYFDNLANTLLVLKLNRNRISAIPP-KMFKLPQLQHLELNRNKIKNVDGLTFQGLGAL 181
            P  F+ L+  L  L L  N + A+ P  +  L +L+ L  N N+I  +   +F+GL +L
Sbjct: 99  HPKTFEKLSR-LEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESL 157

Query: 182 KSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINR 241
             L++  N +  L D  F  L N+  L L+ N +  + K     L  L+ L+LS N +  
Sbjct: 158 VKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQP 217

Query: 242 ISPDAWEFC--QKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLS 299
               A  F   + LS L L+ N+L  L    F  L  L  L +  N+++++A  AF GL 
Sbjct: 218 SLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLE 277

Query: 300 SLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSD 359
           +L+ L L+ N +S   +        L  L  L L GN + ++    F  L  L  L L +
Sbjct: 278 ALRELRLEGNRLS---QLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRN 334

Query: 360 NAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQS---FVNASCAHPQ 416
           NA+ +L G+ F+    L +L L+ +   CDC+L+ L +W+ + + Q     V   C HP 
Sbjct: 335 NALSALSGDIFAASPALYRLDLDGNGWTCDCRLRGLKRWMGDWHSQGRLLTVFVQCRHPP 394

Query: 417 LLKGRSIFAVS----PDGFVCDDFPKPQITVQPETQ 448
            L+G+ +  +      +G   D  P   +T     Q
Sbjct: 395 ALRGKYLDYLDDQQLQNGSCADPSPSASLTADRRRQ 430



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 89/313 (28%), Positives = 132/313 (42%), Gaps = 29/313 (9%)

Query: 8   FSLCLLFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIP--NLGPVSANITL 65
           F    L  + R DL +N++  +   +   L  L E+ L NN L+ +    L P+   + +
Sbjct: 77  FDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLR-KLRI 135

Query: 66  LSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAF--PALQLKYLYLNSNRVTSME 123
           L   GN I  +     +  +SL  L L  N +  L  A   P   L YL+L SNR+  + 
Sbjct: 136 LYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLG 195

Query: 124 PGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKS 183
              F  L   L  L L+ N +          P L+H              TF  L +L S
Sbjct: 196 KNAFAQLGK-LRFLNLSANELQ---------PSLRH------------AATFAPLRSLSS 233

Query: 184 LKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRIS 243
           L +  N +  L    F  L  + +L L  N LT +     +GL  L+EL L  N ++++ 
Sbjct: 234 LILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLP 293

Query: 244 PDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKT 303
               E    L  LDL+ N LS L  ++F  L  L  L + NN +S ++   F    +L  
Sbjct: 294 TALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYR 353

Query: 304 LDLKNNEISWTIE 316
           LDL  N   WT +
Sbjct: 354 LDLDGN--GWTCD 364


>gi|51317373 netrin-G1 ligand [Homo sapiens]
          Length = 640

 Score =  126 bits (317), Expect = 9e-29
 Identities = 121/428 (28%), Positives = 191/428 (44%), Gaps = 33/428 (7%)

Query: 160 LELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEIT 219
           L L+ N+I+ +   +F+ L  L+ L++ RN +  +  GAF GL+N+  L+L  N LT I 
Sbjct: 81  LNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIP 140

Query: 220 KGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDL-TFNHLSRLDDSSFLGLSLLN 278
            G    L  L+EL L  N I  I   A+     L  LDL     LS + + +F GLS L 
Sbjct: 141 NGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLR 200

Query: 279 TLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRI 338
            L++    +  I +     L  L  LDL  N +S       G+F GL  L++L +  ++I
Sbjct: 201 YLNLAMCNLREIPN--LTPLIKLDELDLSGNHLS---AIRPGSFQGLMHLQKLWMIQSQI 255

Query: 339 RSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQW 398
           + I + AF  L +L  ++L+ N +  L  + F+ +  L+++HL+ +   C+C + WL  W
Sbjct: 256 QVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLSWW 315

Query: 399 VAE-NNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLS 457
           + +     +   A C  P  LKGR I  +  + F C     P I   P   +  +G    
Sbjct: 316 IKDMAPSNTACCARCNTPPNLKGRYIGELDQNYFTC---YAPVIVEPPADLNVTEGMAAE 372

Query: 458 FICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEG 517
             C A++S  S +++       + H A     A L             L    V     G
Sbjct: 373 LKCRASTSLTS-VSWITPNGTVMTHGAYKVRIAVLS---------DGTLNFTNVTVQDTG 422

Query: 518 KYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDL--TIRAGAM------ARLECAAVGH 569
            Y C++SN  G++    A  T+N+  + T TP     T+    M      AR     VG 
Sbjct: 423 MYTCMVSNSVGNT---TASATLNVTAA-TTTPFSYFSTVTVETMEPSQDEARTTDNNVG- 477

Query: 570 PAPQIAWQ 577
           P P + W+
Sbjct: 478 PTPVVDWE 485



 Score = 87.8 bits (216), Expect = 5e-17
 Identities = 78/271 (28%), Positives = 130/271 (47%), Gaps = 36/271 (13%)

Query: 59  VSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNR 118
           +S N  LL+L  N+I  I     K  + LE L LS N+I                     
Sbjct: 74  ISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHI--------------------- 112

Query: 119 VTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMF-KLPQLQHLELNRNKIKNVDGLTFQG 177
             ++E G F+ LAN L  L+L  NR++ IP   F  L +L+ L L  N I+++    F  
Sbjct: 113 -RTIEIGAFNGLAN-LNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNR 170

Query: 178 LGALKSLKM-QRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQ 236
           + +L+ L + +   ++ + +GAF GLSN+  L L   NL EI    L  L+ L EL LS 
Sbjct: 171 IPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPN--LTPLIKLDELDLSG 228

Query: 237 NAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFR 296
           N ++ I P +++    L +L +  + +  ++ ++F  L  L  +++ +N ++ +    F 
Sbjct: 229 NHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFT 288

Query: 297 GLSSLKTLDLKNNE---------ISWTIEDM 318
            L  L+ + L +N          +SW I+DM
Sbjct: 289 PLHHLERIHLHHNPWNCNCDILWLSWWIKDM 319



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 67/226 (29%), Positives = 110/226 (48%), Gaps = 8/226 (3%)

Query: 20  DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS--ANITLLSLAGNRIVEIL 77
           +L  N++  IK +S  HL+ L  ++L+ N + TI  +G  +  AN+  L L  NR+  I 
Sbjct: 82  NLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTI-EIGAFNGLANLNTLELFDNRLTTIP 140

Query: 78  PEHLKEFQSLETLDLSSNNISELQT-AFPAL-QLKYLYLNS-NRVTSMEPGYFDNLANTL 134
                    L+ L L +N I  + + AF  +  L+ L L    R++ +  G F+ L+N L
Sbjct: 141 NGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSN-L 199

Query: 135 LVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKL 194
             L L    +  IP  +  L +L  L+L+ N +  +   +FQGL  L+ L M ++ +  +
Sbjct: 200 RYLNLAMCNLREIP-NLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVI 258

Query: 195 MDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAIN 240
              AF  L ++  + L HNNLT +       L  L+ +HL  N  N
Sbjct: 259 ERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWN 304



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 51/205 (24%), Positives = 92/205 (44%), Gaps = 30/205 (14%)

Query: 13  LFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIP----NLGPVSANITLLSL 68
           L +++  +L  NRL+ I   +  +L  L+E+ L NN +E+IP    N  P    + L  L
Sbjct: 123 LANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGEL 182

Query: 69  AGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFD 128
              R+  I     +   +L  L+L+  N+ E+    P ++L  L L+ N ++++ PG F 
Sbjct: 183 --KRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQ 240

Query: 129 NLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQR 188
            L +                        LQ L + +++I+ ++   F  L +L  + +  
Sbjct: 241 GLMH------------------------LQKLWMIQSQIQVIERNAFDNLQSLVEINLAH 276

Query: 189 NGVTKLMDGAFWGLSNMEILQLDHN 213
           N +T L    F  L ++E + L HN
Sbjct: 277 NNLTLLPHDLFTPLHHLERIHLHHN 301



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 33/132 (25%), Positives = 54/132 (40%), Gaps = 5/132 (3%)

Query: 543 PSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFF 602
           P   + P DL +  G  A L+C A       ++W    GT       +    +  D    
Sbjct: 354 PVIVEPPADLNVTEGMAAELKCRA-STSLTSVSWITPNGTVMTHGAYKVRIAVLSDGTLN 412

Query: 603 IVDVKIEDIGVYSCTAQNSAGSISANATLTV---LETP-SFLRPLLDRTVTKGETAVLQC 658
             +V ++D G+Y+C   NS G+ +A+ATL V     TP S+   +   T+   +      
Sbjct: 413 FTNVTVQDTGMYTCMVSNSVGNTTASATLNVTAATTTPFSYFSTVTVETMEPSQDEARTT 472

Query: 659 IAGGSPPPKLNW 670
                P P ++W
Sbjct: 473 DNNVGPTPVVDW 484



 Score = 35.8 bits (81), Expect = 0.22
 Identities = 25/96 (26%), Positives = 41/96 (42%), Gaps = 4/96 (4%)

Query: 637 PSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERH---FFAAGNQLLI 693
           P  + P  D  VT+G  A L+C A  S    ++W   +  ++    +        +  L 
Sbjct: 354 PVIVEPPADLNVTEGMAAELKCRASTSLT-SVSWITPNGTVMTHGAYKVRIAVLSDGTLN 412

Query: 694 IVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729
             +  V D G YTC +SN++G    +  L+V    T
Sbjct: 413 FTNVTVQDTGMYTCMVSNSVGNTTASATLNVTAATT 448


>gi|62912470 leucine-rich repeat-containing G protein-coupled
           receptor 6 isoform 1 [Homo sapiens]
          Length = 967

 Score =  125 bits (315), Expect = 2e-28
 Identities = 84/263 (31%), Positives = 134/263 (50%), Gaps = 8/263 (3%)

Query: 121 SMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLG 179
           S  PG  D L      L L+ N ++ + P +F  L  L+ L L+ N + ++ G  F GL 
Sbjct: 58  SAVPGDLDPLT---AYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLY 114

Query: 180 ALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAI 239
           +LK L +Q N +  +   A W L +++ L+LD N ++ + +    GL  L+ L L  NA+
Sbjct: 115 SLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNAL 174

Query: 240 NRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLS 299
             I   A      L  + L  N +S + D +F  L+ L  LH+ NNR+ ++   +F GL 
Sbjct: 175 TEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLH 234

Query: 300 SLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSD 359
           +L+TLDL  N+    +++   A   L +L+ L    N I++I +KAF G   L+ +   D
Sbjct: 235 NLETLDLNYNK----LQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYD 290

Query: 360 NAIMSLQGNAFSQMKKLQQLHLN 382
           N I  +  +AF  + KL  L LN
Sbjct: 291 NPIQFVGRSAFQYLPKLHTLSLN 313



 Score =  123 bits (308), Expect = 1e-27
 Identities = 113/374 (30%), Positives = 184/374 (49%), Gaps = 18/374 (4%)

Query: 20  DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSA-NITLLSLAGNRIVEILP 78
           DLS N L+ ++     HL+ L E++L+ N L  IP        ++ +L L  N++  I  
Sbjct: 72  DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 131

Query: 79  EHLKEFQSLETLDLSSNNISEL-QTAFPALQ-LKYLYLNSNRVTSMEPGYFDNLANTLLV 136
           E L E  SL++L L +N IS + + +F  L  L++L+L+ N +T +     +NL   L  
Sbjct: 132 EALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLP-ALQA 190

Query: 137 LKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLM 195
           + L  NRIS IP   F+ L  L  L L+ N+I+++   +F+GL  L++L +  N + +  
Sbjct: 191 MTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF- 249

Query: 196 DGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSE 255
             A   L  ++ L   +NN+  I +    G  +LQ +H   N I  +   A+++  KL  
Sbjct: 250 PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHT 309

Query: 256 LDLTFNHLSRLDDSSF---LGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEIS 312
           L L       +D   F    G + L  L +    +  +     + L  L+ L+L +N+I 
Sbjct: 310 LSLN----GAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQI- 364

Query: 313 WTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQ 372
              E++  +     KL  + LQ NRI  I    F+ L +L+ LDLS NAI S+   AFS 
Sbjct: 365 ---EELP-SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFST 420

Query: 373 MKKLQQLHLNTSSL 386
           +  L +L L  + L
Sbjct: 421 LHSLVKLDLTDNQL 434



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 79/293 (26%), Positives = 137/293 (46%), Gaps = 12/293 (4%)

Query: 21  LSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS-ANITLLSLAGNRIVEILPE 79
           L  N L+ I   ++++L +L+ + L  N +  IP+    +  ++ +L L  NRI  +   
Sbjct: 169 LDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTH 228

Query: 80  HLKEFQSLETLDLSSNNISELQTAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLL-VL 137
             +   +LETLDL+ N + E   A   L +L+ L  ++N + ++    F  + N LL  +
Sbjct: 229 SFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAF--MGNPLLQTI 286

Query: 138 KLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMD 196
               N I  +    F+ LP+L  L LN   +   +    +G  +L+ L + R G+  L  
Sbjct: 287 HFYDNPIQFVGRSAFQYLPKLHTLSLN-GAMDIQEFPDLKGTTSLEILTLTRAGIRLLPS 345

Query: 197 GAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSEL 256
           G    L  + +L+L HN + E+    L+    L+E+ L  N I  I  D +     L  L
Sbjct: 346 GMCQQLPRLRVLELSHNQIEELPS--LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQAL 403

Query: 257 DLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNN 309
           DL++N +  +   +F  L  L  L + +N+++ +      GL  L  L LK N
Sbjct: 404 DLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTL---PLAGLGGLMHLKLKGN 453



 Score = 57.4 bits (137), Expect = 7e-08
 Identities = 66/245 (26%), Positives = 109/245 (44%), Gaps = 32/245 (13%)

Query: 21  LSHNRLSFIKASSMSHLQSLREVKLNNNELETIP----------NLGPVSANITLL---S 67
           L +NR+  +   S   L +L  + LN N+L+  P           LG  + NI  +   +
Sbjct: 217 LHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKA 276

Query: 68  LAGNRIVEILPEH--------LKEFQSLETLD-LSSNNISELQTAFPALQ----LKYLYL 114
             GN +++ +  +           FQ L  L  LS N   ++Q  FP L+    L+ L L
Sbjct: 277 FMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQE-FPDLKGTTSLEILTL 335

Query: 115 NSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLT 174
               +  +  G    L   L VL+L+ N+I  +P  + +  +L+ + L  N+I  +   T
Sbjct: 336 TRAGIRLLPSGMCQQLPR-LRVLELSHNQIEELP-SLHRCQKLEEIGLQHNRIWEIGADT 393

Query: 175 FQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQ---E 231
           F  L +L++L +  N +  +   AF  L ++  L L  N LT +    L GL+ L+    
Sbjct: 394 FSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGN 453

Query: 232 LHLSQ 236
           L LSQ
Sbjct: 454 LALSQ 458


>gi|62912472 leucine-rich repeat-containing G protein-coupled
           receptor 6 isoform 2 [Homo sapiens]
          Length = 915

 Score =  125 bits (313), Expect = 3e-28
 Identities = 115/378 (30%), Positives = 186/378 (49%), Gaps = 18/378 (4%)

Query: 16  ISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSA-NITLLSLAGNRIV 74
           IS  DLS N L+ ++     HL+ L E++L+ N L  IP        ++ +L L  N++ 
Sbjct: 16  ISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLG 75

Query: 75  EILPEHLKEFQSLETLDLSSNNISEL-QTAFPALQ-LKYLYLNSNRVTSMEPGYFDNLAN 132
            I  E L E  SL++L L +N IS + + +F  L  L++L+L+ N +T +     +NL  
Sbjct: 76  GIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLP- 134

Query: 133 TLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGV 191
            L  + L  NRIS IP   F+ L  L  L L+ N+I+++   +F+GL  L++L +  N +
Sbjct: 135 ALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKL 194

Query: 192 TKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQ 251
            +    A   L  ++ L   +NN+  I +    G  +LQ +H   N I  +   A+++  
Sbjct: 195 QEF-PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLP 253

Query: 252 KLSELDLTFNHLSRLDDSSF---LGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKN 308
           KL  L L       +D   F    G + L  L +    +  +     + L  L+ L+L +
Sbjct: 254 KLHTLSLN----GAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSH 309

Query: 309 NEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGN 368
           N+I    E++  +     KL  + LQ NRI  I    F+ L +L+ LDLS NAI S+   
Sbjct: 310 NQI----EELP-SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPE 364

Query: 369 AFSQMKKLQQLHLNTSSL 386
           AFS +  L +L L  + L
Sbjct: 365 AFSTLHSLVKLDLTDNQL 382



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 79/293 (26%), Positives = 137/293 (46%), Gaps = 12/293 (4%)

Query: 21  LSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS-ANITLLSLAGNRIVEILPE 79
           L  N L+ I   ++++L +L+ + L  N +  IP+    +  ++ +L L  NRI  +   
Sbjct: 117 LDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTH 176

Query: 80  HLKEFQSLETLDLSSNNISELQTAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLL-VL 137
             +   +LETLDL+ N + E   A   L +L+ L  ++N + ++    F  + N LL  +
Sbjct: 177 SFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAF--MGNPLLQTI 234

Query: 138 KLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMD 196
               N I  +    F+ LP+L  L LN   +   +    +G  +L+ L + R G+  L  
Sbjct: 235 HFYDNPIQFVGRSAFQYLPKLHTLSLN-GAMDIQEFPDLKGTTSLEILTLTRAGIRLLPS 293

Query: 197 GAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSEL 256
           G    L  + +L+L HN + E+    L+    L+E+ L  N I  I  D +     L  L
Sbjct: 294 GMCQQLPRLRVLELSHNQIEELPS--LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQAL 351

Query: 257 DLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNN 309
           DL++N +  +   +F  L  L  L + +N+++ +      GL  L  L LK N
Sbjct: 352 DLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTL---PLAGLGGLMHLKLKGN 401



 Score = 73.6 bits (179), Expect = 9e-13
 Identities = 52/160 (32%), Positives = 78/160 (48%), Gaps = 3/160 (1%)

Query: 227 LMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNR 286
           +++    LS N +  + P  +   + L EL L+ NHLS +   +F GL  L  L + NN+
Sbjct: 14  IIISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQ 73

Query: 287 VSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAF 346
           +  I   A   L SL++L L  N IS   E    +F GL  LR L L  N +  I  +A 
Sbjct: 74  LGGIPAEALWELPSLQSLRLDANLISLVPE---RSFEGLSSLRHLWLDDNALTEIPVRAL 130

Query: 347 TGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 386
             L AL+ + L+ N I  +   AF  +  L  LHL+ + +
Sbjct: 131 NNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRI 170



 Score = 57.4 bits (137), Expect = 7e-08
 Identities = 66/245 (26%), Positives = 109/245 (44%), Gaps = 32/245 (13%)

Query: 21  LSHNRLSFIKASSMSHLQSLREVKLNNNELETIP----------NLGPVSANITLL---S 67
           L +NR+  +   S   L +L  + LN N+L+  P           LG  + NI  +   +
Sbjct: 165 LHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKA 224

Query: 68  LAGNRIVEILPEH--------LKEFQSLETLD-LSSNNISELQTAFPALQ----LKYLYL 114
             GN +++ +  +           FQ L  L  LS N   ++Q  FP L+    L+ L L
Sbjct: 225 FMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQE-FPDLKGTTSLEILTL 283

Query: 115 NSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLT 174
               +  +  G    L   L VL+L+ N+I  +P  + +  +L+ + L  N+I  +   T
Sbjct: 284 TRAGIRLLPSGMCQQLPR-LRVLELSHNQIEELP-SLHRCQKLEEIGLQHNRIWEIGADT 341

Query: 175 FQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQ---E 231
           F  L +L++L +  N +  +   AF  L ++  L L  N LT +    L GL+ L+    
Sbjct: 342 FSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGN 401

Query: 232 LHLSQ 236
           L LSQ
Sbjct: 402 LALSQ 406


>gi|19743806 roundabout 1 isoform b [Homo sapiens]
          Length = 1612

 Score =  124 bits (312), Expect = 4e-28
 Identities = 81/252 (32%), Positives = 118/252 (46%), Gaps = 23/252 (9%)

Query: 471 TFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSS 530
           T +WKKD   L D +      +  +GG++M       +     +  GKY CV +N  G  
Sbjct: 162 TISWKKDGSPLDDKD----ERITIRGGKLM-------ITYTRKSDAGKYVCVGTNMVGER 210

Query: 531 YSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARER 590
            S  A+LTV   PSF K P +L +     A  +C A G P P + W+KD G + P +R  
Sbjct: 211 ESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDG-ELPKSR-- 267

Query: 591 RMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTK 650
             + + +D    I  V   D+G Y+C A+N  G   A+ATLTV E P F+    D+ V  
Sbjct: 268 --YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVAL 325

Query: 651 GETAVLQCIAGGSPPPKLNWTKDDSPLVV-------TERHFFAAGNQLLIIVDSDVSDAG 703
           G T   QC A G+P P + W ++ S  ++       +   F  +    L I +   SD G
Sbjct: 326 GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVG 385

Query: 704 KYTCEMSNTLGT 715
            Y C+  N  G+
Sbjct: 386 YYICQTLNVAGS 397



 Score =  111 bits (278), Expect = 3e-24
 Identities = 86/298 (28%), Positives = 124/298 (41%), Gaps = 13/298 (4%)

Query: 434 DDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLR 493
           +DFP P+I   P      KG   +  C A        T  W K  E +   + +  +H  
Sbjct: 25  EDFP-PRIVEHPSDLIVSKGEPATLNCKAEGRPTP--TIEWYKGGERVETDKDDPRSHRM 81

Query: 494 AQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNML-PSFTKTPMDL 552
                 + +  I+  R+     EG Y CV  N+ G + S  A L V +L   F + P D+
Sbjct: 82  LLPSGSLFFLRIVHGRKSR-PDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDV 140

Query: 553 TIRAGAMARLECAAV-GHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDI 611
            +  G  A +EC    GHP P I+W+KDG        ++   +        I   +  D 
Sbjct: 141 MVAVGEPAVMECQPPRGHPEPTISWKKDGS----PLDDKDERITIRGGKLMITYTRKSDA 196

Query: 612 GVYSCTAQNSAGSISAN-ATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNW 670
           G Y C   N  G   +  A LTVLE PSF++   +  VT  ++A  +C A G P P + W
Sbjct: 197 GKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRW 256

Query: 671 TKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728
            KDD  L   +  +    +  L I      D G YTC   N +G    +  L+V   P
Sbjct: 257 RKDDGEL--PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPP 312



 Score =  109 bits (272), Expect = 2e-23
 Identities = 90/321 (28%), Positives = 131/321 (40%), Gaps = 35/321 (10%)

Query: 438 KPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGG 497
           +P    +P   +     +  F C A    D   T  W+KD     D E+    +      
Sbjct: 222 RPSFVKRPSNLAVTVDDSAEFKCEARG--DPVPTVRWRKD-----DGELPKSRY------ 268

Query: 498 EVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAG 557
           E+ +  T L++R+V     G Y CV  N  G +    A LTV   P F   P D  +  G
Sbjct: 269 EIRDDHT-LKIRKVTAGDMGSYTCVAENMVGKA-EASATLTVQEPPHFVVKPRDQVVALG 326

Query: 558 AMARLECAAVGHPAPQIAWQKDGGTDF-----PAARERRMHVMPEDDVFFIVDVKIEDIG 612
                +C A G+P P I W+++G  +      P     R  V    D+  I +V+  D+G
Sbjct: 327 RTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT-ITNVQRSDVG 385

Query: 613 VYSCTAQNSAGSISANATLTVLET------PSFLRPLLDRTVTKGETAVLQCIAGGSPPP 666
            Y C   N AGSI   A L V +       P   +  +++TV    T VL C+A GSP P
Sbjct: 386 YYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVP 445

Query: 667 KLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSV-- 724
            + W KD   +   +       N +L I  + + D G+YTC  S   G    +  + V  
Sbjct: 446 TILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQE 505

Query: 725 ------IPTPTCDSPQMTAPS 739
                  P PT  +   +APS
Sbjct: 506 FGVPVQPPRPTDPNLIPSAPS 526



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 75/212 (35%), Positives = 102/212 (48%), Gaps = 14/212 (6%)

Query: 543 PSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDG---GTDFPAARERRMHVMPEDD 599
           P   + P DL +  G  A L C A G P P I W K G    TD    R  RM ++P   
Sbjct: 29  PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM-LLPSGS 87

Query: 600 VFFIVDV----KIEDIGVYSCTAQNSAG-SISANATLTV-LETPSFLRPLLDRTVTKGET 653
           +FF+  V       D GVY C A+N  G ++S NA+L V +    F +   D  V  GE 
Sbjct: 88  LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 147

Query: 654 AVLQC-IAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNT 712
           AV++C    G P P ++W KD SPL   +      G +L+I   +  SDAGKY C  +N 
Sbjct: 148 AVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITY-TRKSDAGKYVCVGTNM 206

Query: 713 LGTERGNV-RLSVIPTPT-CDSPQMTAPSLDD 742
           +G     V  L+V+  P+    P   A ++DD
Sbjct: 207 VGERESEVAELTVLERPSFVKRPSNLAVTVDD 238


>gi|4506569 roundabout 1 isoform a [Homo sapiens]
          Length = 1651

 Score =  124 bits (312), Expect = 4e-28
 Identities = 81/252 (32%), Positives = 118/252 (46%), Gaps = 23/252 (9%)

Query: 471 TFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSS 530
           T +WKKD   L D +      +  +GG++M       +     +  GKY CV +N  G  
Sbjct: 201 TISWKKDGSPLDDKD----ERITIRGGKLM-------ITYTRKSDAGKYVCVGTNMVGER 249

Query: 531 YSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARER 590
            S  A+LTV   PSF K P +L +     A  +C A G P P + W+KD G + P +R  
Sbjct: 250 ESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDG-ELPKSR-- 306

Query: 591 RMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTK 650
             + + +D    I  V   D+G Y+C A+N  G   A+ATLTV E P F+    D+ V  
Sbjct: 307 --YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVAL 364

Query: 651 GETAVLQCIAGGSPPPKLNWTKDDSPLVV-------TERHFFAAGNQLLIIVDSDVSDAG 703
           G T   QC A G+P P + W ++ S  ++       +   F  +    L I +   SD G
Sbjct: 365 GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVG 424

Query: 704 KYTCEMSNTLGT 715
            Y C+  N  G+
Sbjct: 425 YYICQTLNVAGS 436



 Score =  111 bits (278), Expect = 3e-24
 Identities = 86/298 (28%), Positives = 124/298 (41%), Gaps = 13/298 (4%)

Query: 434 DDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLR 493
           +DFP P+I   P      KG   +  C A        T  W K  E +   + +  +H  
Sbjct: 64  EDFP-PRIVEHPSDLIVSKGEPATLNCKAEGRPTP--TIEWYKGGERVETDKDDPRSHRM 120

Query: 494 AQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNML-PSFTKTPMDL 552
                 + +  I+  R+     EG Y CV  N+ G + S  A L V +L   F + P D+
Sbjct: 121 LLPSGSLFFLRIVHGRKSR-PDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDV 179

Query: 553 TIRAGAMARLECAAV-GHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDI 611
            +  G  A +EC    GHP P I+W+KDG        ++   +        I   +  D 
Sbjct: 180 MVAVGEPAVMECQPPRGHPEPTISWKKDGS----PLDDKDERITIRGGKLMITYTRKSDA 235

Query: 612 GVYSCTAQNSAGSISAN-ATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNW 670
           G Y C   N  G   +  A LTVLE PSF++   +  VT  ++A  +C A G P P + W
Sbjct: 236 GKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRW 295

Query: 671 TKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728
            KDD  L   +  +    +  L I      D G YTC   N +G    +  L+V   P
Sbjct: 296 RKDDGEL--PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPP 351



 Score =  109 bits (272), Expect = 2e-23
 Identities = 90/321 (28%), Positives = 131/321 (40%), Gaps = 35/321 (10%)

Query: 438 KPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGG 497
           +P    +P   +     +  F C A    D   T  W+KD     D E+    +      
Sbjct: 261 RPSFVKRPSNLAVTVDDSAEFKCEARG--DPVPTVRWRKD-----DGELPKSRY------ 307

Query: 498 EVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAG 557
           E+ +  T L++R+V     G Y CV  N  G +    A LTV   P F   P D  +  G
Sbjct: 308 EIRDDHT-LKIRKVTAGDMGSYTCVAENMVGKA-EASATLTVQEPPHFVVKPRDQVVALG 365

Query: 558 AMARLECAAVGHPAPQIAWQKDGGTDF-----PAARERRMHVMPEDDVFFIVDVKIEDIG 612
                +C A G+P P I W+++G  +      P     R  V    D+  I +V+  D+G
Sbjct: 366 RTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT-ITNVQRSDVG 424

Query: 613 VYSCTAQNSAGSISANATLTVLET------PSFLRPLLDRTVTKGETAVLQCIAGGSPPP 666
            Y C   N AGSI   A L V +       P   +  +++TV    T VL C+A GSP P
Sbjct: 425 YYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVP 484

Query: 667 KLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSV-- 724
            + W KD   +   +       N +L I  + + D G+YTC  S   G    +  + V  
Sbjct: 485 TILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQE 544

Query: 725 ------IPTPTCDSPQMTAPS 739
                  P PT  +   +APS
Sbjct: 545 FGVPVQPPRPTDPNLIPSAPS 565



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 75/212 (35%), Positives = 102/212 (48%), Gaps = 14/212 (6%)

Query: 543 PSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDG---GTDFPAARERRMHVMPEDD 599
           P   + P DL +  G  A L C A G P P I W K G    TD    R  RM ++P   
Sbjct: 68  PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM-LLPSGS 126

Query: 600 VFFIVDV----KIEDIGVYSCTAQNSAG-SISANATLTV-LETPSFLRPLLDRTVTKGET 653
           +FF+  V       D GVY C A+N  G ++S NA+L V +    F +   D  V  GE 
Sbjct: 127 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 186

Query: 654 AVLQC-IAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNT 712
           AV++C    G P P ++W KD SPL   +      G +L+I   +  SDAGKY C  +N 
Sbjct: 187 AVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITY-TRKSDAGKYVCVGTNM 245

Query: 713 LGTERGNV-RLSVIPTPT-CDSPQMTAPSLDD 742
           +G     V  L+V+  P+    P   A ++DD
Sbjct: 246 VGERESEVAELTVLERPSFVKRPSNLAVTVDD 277


>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
          Length = 560

 Score =  124 bits (310), Expect = 6e-28
 Identities = 105/379 (27%), Positives = 183/379 (48%), Gaps = 9/379 (2%)

Query: 29  IKASSMSHLQSLREVKLNNNELETI-PNLGPVSANITLLSLAGNRIVEILPEHLKEFQSL 87
           +++ S S +  L+ + ++++ +  + P        +  L L+ N+I  +    L +   L
Sbjct: 65  LQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLL 124

Query: 88  ETLDLSSNNISEL-QTAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRIS 145
           E L L  N +  + Q  F  L  L+ L LN N++  +    F NL N L +L L+ N ++
Sbjct: 125 EQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLEN-LKLLDLSGNNLT 183

Query: 146 AIPPKMFKLP-QLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSN 204
            +P  +     +L+ L L+ N++ ++D      LGAL  L+  RN +  +  GAF  L N
Sbjct: 184 HLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPN 243

Query: 205 MEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLS 264
           +  L L  N+L  +          L  L L +N +  +    +     L EL L    L 
Sbjct: 244 LSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLR 303

Query: 265 RLDDSSFLGLSLLNTLHIG-NNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFS 323
            L  ++F  LS L  L +  + R+S +   AF+GL  L+ L L +N ++  + D  G   
Sbjct: 304 TLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLT-ALPD--GLLR 360

Query: 324 GLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNT 383
           GL KLR++ L+ NR+R++ +  F  L +LE + L  N + +L G+ F  + +L ++ L  
Sbjct: 361 GLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGH 420

Query: 384 SSLLCDCQLKWLPQWVAEN 402
           +S  CDC L     W+ ++
Sbjct: 421 NSWRCDCGLGPFLGWLRQH 439



 Score =  102 bits (253), Expect = 2e-21
 Identities = 86/302 (28%), Positives = 136/302 (45%), Gaps = 32/302 (10%)

Query: 21  LSHNRLSFIKASSMSHLQSLREVKLNNNELETIP-NLGPVSANITLLSLAGNRIVEILPE 79
           L HN L  I  +    L +L+E+ LN N+L+ +P +L     N+ LL L+GN +  +   
Sbjct: 129 LDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKG 188

Query: 80  HLKEFQSLETLDLSSNNISELQTAF--PALQLKYLYLNSNRVTSMEPGYFDNLANTLLVL 137
            L     LE L L SN +  L +        L  L  + N + S+ PG FD L N L  L
Sbjct: 189 LLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPN-LSSL 247

Query: 138 KLNRNRISAIPPKMF-------------------------KLPQLQHLELNRNKIKNVDG 172
            L+RN ++ +P  +F                         ++  LQ L LNR +++ +  
Sbjct: 248 TLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPA 307

Query: 173 LTFQGLGALKSLKMQRN-GVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQE 231
             F+ L  L+ L +  +  ++ L  GAF GL  +++L L  N LT +  G L GL  L++
Sbjct: 308 AAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQ 367

Query: 232 LHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIA 291
           + L +N +  +    +     L  + L  N L  L    F  L  L  + +G+N  S+  
Sbjct: 368 VSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHN--SWRC 425

Query: 292 DC 293
           DC
Sbjct: 426 DC 427


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score =  123 bits (309), Expect = 8e-28
 Identities = 87/292 (29%), Positives = 130/292 (44%), Gaps = 17/292 (5%)

Query: 437 PKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQG 496
           P P I V P   +   G      C   S+ D  +T  W++++    D  +   A +R   
Sbjct: 519 PPPVIQV-PNNVTVTPGERAVLTCLIISAVDYNLT--WQRNDR---DVRLAEPARIRTLA 572

Query: 497 GEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRA 556
              +E      L+ V+F   G+Y C++S+  GSS +    LTV   P  T  P + +   
Sbjct: 573 NLSLE------LKSVKFNDAGEYHCMVSSEGGSS-AASVFLTVQEPPKVTVMPKNQSFTG 625

Query: 557 GAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSC 616
           G+   + C+A G+P P+IAW  +      + R R    M  D   FI +   +D G+Y C
Sbjct: 626 GSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYR----MTSDGTLFIKNAAPKDAGIYGC 681

Query: 617 TAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSP 676
            A NSAG+   N+TL  +E P  +    +  V  G+  V++C   G PPP++ W K D  
Sbjct: 682 LASNSAGTDKQNSTLRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKGDLE 741

Query: 677 LVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728
           L  +          LL I ++   DAG YTC   N  G   G + L V   P
Sbjct: 742 LRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPP 793



 Score =  120 bits (301), Expect = 7e-27
 Identities = 82/288 (28%), Positives = 128/288 (44%), Gaps = 19/288 (6%)

Query: 446  ETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTI 505
            E +  I  + +S  C   +++  P T  W KD   L  ++      L   GG V      
Sbjct: 2785 EAKDVIINNPISLYCE--TNAAPPPTLTWYKDGHPLTSSDKV----LILPGGRV------ 2832

Query: 506  LRLREVEFASEGKYQCVISNHFGSS---YSVKAKLTVNMLPSFTKTPMDLTIRAGAMARL 562
            L++   +    G+Y CV  N  G     Y V+  +   +  + +  P ++T+     A +
Sbjct: 2833 LQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALI 2892

Query: 563  ECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSA 622
            EC + G PAP+ +WQKDG    P   +     +    +  I++ +I DIG Y C A+N+A
Sbjct: 2893 ECLSSGSPAPRNSWQKDGQ---PLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTA 2949

Query: 623  GSISANATLTVLETPSFLRPLLDR-TVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTE 681
            GS      L V   PS + P  +  TV       L C   G PPP L+W K++ P+ +  
Sbjct: 2950 GSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNT 3009

Query: 682  RHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729
                  G + L I+ + VSD G+YTC   N  G  +    L+V   P+
Sbjct: 3010 NTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPS 3057



 Score =  120 bits (300), Expect = 9e-27
 Identities = 80/283 (28%), Positives = 132/283 (46%), Gaps = 21/283 (7%)

Query: 452  KGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREV 511
            +G ++S  C        P T  W KD   L          ++A+G E+++   IL+L+ +
Sbjct: 2306 RGKSISLECEVQGIP--PPTVTWMKDGHPL----------IKAKGVEILDEGHILQLKNI 2353

Query: 512  EFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFT---KTPMDLTIRAGAMARLECAAVG 568
              +  G+Y CV  N  G +   K  L+V+  PS     ++P ++++       L C A G
Sbjct: 2354 HVSDTGRYVCVAVNVAGMT-DKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASG 2412

Query: 569  HPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISAN 628
             P P I W KDG   +P +    + ++    +  ++   +ED G Y+C  +N+AG     
Sbjct: 2413 IPLPSITWFKDG---WPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKI 2469

Query: 629  ATLTVLETPSFL--RPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFA 686
              L+VL  P  +    L D  V + ++  L C   G+P P++ W KD  PL   E H   
Sbjct: 2470 FGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHII 2529

Query: 687  AGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729
            +G + L I +  V   G+YTC  S+  G +  +  L+V  +PT
Sbjct: 2530 SGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPT 2572



 Score =  113 bits (282), Expect = 1e-24
 Identities = 87/331 (26%), Positives = 145/331 (43%), Gaps = 24/331 (7%)

Query: 445  PETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTT 504
            PE +  ++  +     +  ++   P T AW K+++      +EN   L  +   ++   +
Sbjct: 3156 PEREVIVETISNPVTLTCDATGIPPPTIAWLKNHK-----RIENSDSLEVR---ILSGGS 3207

Query: 505  ILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFT--KTPMDLTIRAGAMARL 562
             L++   + +  G Y C+ SN  G +      L++ + PS    + P D+++  G    L
Sbjct: 3208 KLQIARSQHSDSGNYTCIASNMEGKAQKYYF-LSIQVPPSVAGAEIPSDVSVLLGENVEL 3266

Query: 563  ECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSA 622
             C A G P P I W KDG     +    R+ V        I      D G Y+C A N A
Sbjct: 3267 VCNANGIPTPLIQWLKDG-KPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPA 3325

Query: 623  GSISANATLTVLETPSFL--RPLLDRTVTKGETAV-LQCIAGGSPPPKLNWTKDDSPLVV 679
            G       L V  TP+    +   ++ +T  +T++ ++C A G+PPP++NW K+  PL +
Sbjct: 3326 GEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLPLPL 3385

Query: 680  TERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQMTAPS 739
            +      A  Q++ IV + VSD   YTC  SN  G +  +  L V   P  D+   T   
Sbjct: 3386 SSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEI 3445

Query: 740  LDDDGWATVGVVIIAVVCCVVGT---SLVWV 767
                G +T      ++ C   GT   S+ W+
Sbjct: 3446 TVLKGSST------SMACITDGTPAPSMAWL 3470



 Score =  112 bits (281), Expect = 1e-24
 Identities = 78/280 (27%), Positives = 130/280 (46%), Gaps = 30/280 (10%)

Query: 471  TFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSS 530
            + +W KD + L   + +++ ++ A G         L+++E + +  G+Y CV SN  G  
Sbjct: 2705 SLSWYKDGQPL---KSDDHVNIAANGHT-------LQIKEAQISDTGRYTCVASNIAGED 2754

Query: 531  YSVKAKLTVNMLPSFTKT----PMDLTIRAGAMA--------RLECAAVGHPAPQIAWQK 578
              +   + + + PSF K      M  T R G            L C     P P + W K
Sbjct: 2755 -ELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYK 2813

Query: 579  DGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPS 638
            DG    P     ++ ++P   V  I   K+ED G Y+C A N AG  S    + VL  P 
Sbjct: 2814 DG---HPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPI 2870

Query: 639  FLRPLLDR----TVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLII 694
                  D     TV   ++A+++C++ GSP P+ +W KD  PL+  + H F +  ++L I
Sbjct: 2871 IKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQI 2930

Query: 695  VDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQ 734
            +++ ++D G+Y C   NT G+ +    L+V   P+   P+
Sbjct: 2931 LNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPK 2970



 Score =  111 bits (277), Expect = 4e-24
 Identities = 77/278 (27%), Positives = 125/278 (44%), Gaps = 16/278 (5%)

Query: 460  CSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKY 519
            C AA +    +T  W KDN LL  +    + + R Q         I+ +   + +  G Y
Sbjct: 1942 CKAAGNPVPVIT--WYKDNRLLSGSTSMTFLN-RGQ---------IIDIESAQISDAGIY 1989

Query: 520  QCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKD 579
            +CV  N  G++  +   L V++ PS + +   + +      RLEC A G PAP + W KD
Sbjct: 1990 KCVAINSAGAT-ELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKD 2048

Query: 580  GGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSF 639
            G     ++    + V+    +  +   +I D G Y+C A N+AG    +  L V   P+ 
Sbjct: 2049 GSP--VSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNI 2106

Query: 640  LRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDV 699
            +    + +V   +   L C +   PPP L W KD  PL+       +    +L I D+ V
Sbjct: 2107 MGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQV 2166

Query: 700  SDAGKYTCEMSNTLGTERGNVRLSV-IPTPTCDSPQMT 736
             D G+YTCE +N  G    N  +++ +P     S ++T
Sbjct: 2167 QDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELT 2204



 Score =  109 bits (273), Expect = 1e-23
 Identities = 78/289 (26%), Positives = 125/289 (43%), Gaps = 19/289 (6%)

Query: 445  PETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTT 504
            P   S + G N+  +C+A +   +P+   W KD + +   E E    + A G  +  Y  
Sbjct: 3253 PSDVSVLLGENVELVCNA-NGIPTPL-IQWLKDGKPIASGETERI-RVSANGSTLNIYGA 3309

Query: 505  ILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMD---LTIRAGAMAR 561
            +        +  GKY CV +N  G    +   L V + P+      +   L         
Sbjct: 3310 LT-------SDTGKYTCVATNPAGEEDRI-FNLNVYVTPTIRGNKDEAEKLMTLVDTSIN 3361

Query: 562  LECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNS 621
            +EC A G P PQI W K+G    P      + ++    V  IV  ++ D+ VY+C A N 
Sbjct: 3362 IECRATGTPPPQINWLKNG---LPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNR 3418

Query: 622  AGSISANATLTVLETPSFLRPL--LDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVV 679
            AG  + +  L V   P+    +   + TV KG +  + CI  G+P P + W +D  PL +
Sbjct: 3419 AGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGL 3478

Query: 680  TERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728
                  +    +L ++ ++  D+GKYTC  SN  G    +  L V+  P
Sbjct: 3479 DAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPP 3527



 Score =  103 bits (258), Expect = 7e-22
 Identities = 85/291 (29%), Positives = 122/291 (41%), Gaps = 17/291 (5%)

Query: 439  PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 498
            P I  QP     I  + +   C A  +    +T  W+K+   ++ +   N+A L + G  
Sbjct: 3988 PVIQPQPSELHVILNNPILLPCEATGTPSPFIT--WQKEGINVNTSG-RNHAVLPSGG-- 4042

Query: 499  VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGA 558
                   L++        G Y CV  N  G++   K KL V + P  +    +  I    
Sbjct: 4043 -------LQISRAVREDAGTYMCVAQNPAGTALG-KIKLNVQVPPVISPHLKEYVIAVDK 4094

Query: 559  MARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTA 618
               L C A G P P I W KDG     + R+R +          I  V+  D G Y+C A
Sbjct: 4095 PITLSCEADGLPPPDITWHKDGRAIVESIRQRVL----SSGSLQIAFVQPGDAGHYTCMA 4150

Query: 619  QNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLV 678
             N AGS S +  LTV   P         TV +   A+L C+A G P P +NW KD+  L 
Sbjct: 4151 ANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLA 4210

Query: 679  VTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729
                 + A     LI+ +  + D+G YTC  +N  G +   V L+V   PT
Sbjct: 4211 NLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPT 4261



 Score =  103 bits (256), Expect = 1e-21
 Identities = 73/281 (25%), Positives = 117/281 (41%), Gaps = 12/281 (4%)

Query: 448  QSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILR 507
            QS +   N S +    +         W+KD  +L      N+A        ++E    L 
Sbjct: 3720 QSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAG----NHARY-----SILE-NGFLH 3769

Query: 508  LREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAV 567
            ++       G+Y C+ +N  G+    +  L V++ PS    P ++T+       L C A 
Sbjct: 3770 IQSAHVTDTGRYLCMATNAAGTDRR-RIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEAT 3828

Query: 568  GHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISA 627
            G P P I W+K+G       + +  + +       I+   ++D   Y CT  N AG    
Sbjct: 3829 GIPKPSINWRKNGHL-LNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKR 3887

Query: 628  NATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAA 687
               LTV   PS      D  VTK   AV+ C A G P P ++WTK+   L+     +   
Sbjct: 3888 TVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRIL 3947

Query: 688  GNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728
             +  + I+ + ++ AG+YTC   N  G+   +V L V   P
Sbjct: 3948 SSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPP 3988



 Score =  102 bits (254), Expect = 2e-21
 Identities = 78/287 (27%), Positives = 118/287 (41%), Gaps = 20/287 (6%)

Query: 446  ETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTI 505
            E  S I  + L   C A+      MT  W KD   L   +          GGEV      
Sbjct: 3536 EEISVIVNNPLELTCIASGIPAPKMT--WMKDGRPLPQTDQVQ----TLGGGEV------ 3583

Query: 506  LRLREVEFASEGKYQCVISNHFGSS---YSVKAKLTVNMLPSFTKTPMDLTIRAGAMARL 562
            LR+   +    G+Y C+ S+  G     Y V+  +  N+  + T  P D+T+       L
Sbjct: 3584 LRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNI--AGTDEPRDITVLRNRQVTL 3641

Query: 563  ECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSA 622
            EC +   P P I W ++G          R+ ++       I +  + D   Y+C A N A
Sbjct: 3642 ECKSDAVPPPVITWLRNGER---LQATPRVRILSGGRYLQINNADLGDTANYTCVASNIA 3698

Query: 623  GSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTER 682
            G  +    LTV   P+         +   ++ VL+CIA G P P++ W KD + L     
Sbjct: 3699 GKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHA 3758

Query: 683  HFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729
             +    N  L I  + V+D G+Y C  +N  GT+R  + L V   P+
Sbjct: 3759 RYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPS 3805



 Score =  102 bits (254), Expect = 2e-21
 Identities = 78/256 (30%), Positives = 107/256 (41%), Gaps = 18/256 (7%)

Query: 474  WKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSV 533
            WKKDN LL +            G    E    L L  V     G Y CV +N  G     
Sbjct: 4202 WKKDNVLLANL----------LGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHT 4251

Query: 534  KAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMH 593
               LTV++LP+FT+ P D+++  G   RL C A G P P++ W  +     PA       
Sbjct: 4252 -VSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNI-IPA----HFD 4305

Query: 594  VMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTK-GE 652
             +       I  V  ED G Y CTA+NS G + A   + V E P F        +   G 
Sbjct: 4306 SVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGG 4365

Query: 653  TAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNT 712
             A+L C   G P P + W +    + ++ R     GN  L I  +   DAG YTC  +N 
Sbjct: 4366 NAILNCEVKGDPTPTIQWNRKGVDIEISHR-IRQLGNGSLAIYGTVNEDAGDYTCVATNE 4424

Query: 713  LGTERGNVRLSVIPTP 728
             G    ++ L++   P
Sbjct: 4425 AGVVERSMSLTLQSPP 4440



 Score =  102 bits (253), Expect = 2e-21
 Identities = 77/285 (27%), Positives = 119/285 (41%), Gaps = 19/285 (6%)

Query: 455  NLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFA 514
            N S +    SS       +W+KD + L    +E+  H     G       IL++   +  
Sbjct: 2887 NKSALIECLSSGSPAPRNSWQKDGQPL----LEDDHHKFLSNGR------ILQILNTQIT 2936

Query: 515  SEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMD-LTIRAGAMARLECAAVGHPAPQ 573
              G+Y CV  N  GS+      L V++ PS      + LT+       L C   G P P 
Sbjct: 2937 DIGRYVCVAENTAGSAKKY-FNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPD 2995

Query: 574  IAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTV 633
            ++W K+   + P        ++P      I+  K+ D G Y+C A N AG      +LTV
Sbjct: 2996 LSWLKN---EQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTV 3052

Query: 634  LETPSFL----RPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGN 689
               PS        L    V +G +  L+C +   PPP + W K+   +  +      A  
Sbjct: 3053 YVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADG 3112

Query: 690  QLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQ 734
            Q+L I  ++VSD G+Y C   N  G +  N  L+V   P+ + P+
Sbjct: 3113 QMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPE 3157



 Score =  101 bits (252), Expect = 3e-21
 Identities = 69/210 (32%), Positives = 101/210 (48%), Gaps = 8/210 (3%)

Query: 506  LRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECA 565
            L++  V+    G Y C+ +N  GSS S   KLTV++ P    T    T+   + A L C 
Sbjct: 4133 LQIAFVQPGDAGHYTCMAANVAGSS-STSTKLTVHVPPRIRSTEGHYTVNENSQAILPCV 4191

Query: 566  AVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSI 625
            A G P P I W+KD   +   A     +         + +V +ED G Y+C A N+AG  
Sbjct: 4192 ADGIPTPAINWKKD---NVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGED 4248

Query: 626  SANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFF 685
            +   +LTV   P+F     D ++ KGE   L C A G P PKL WT +++   +   HF 
Sbjct: 4249 THTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNN---IIPAHFD 4305

Query: 686  AA-GNQLLIIVDSDVSDAGKYTCEMSNTLG 714
            +  G+  L+I      D+G Y C   N++G
Sbjct: 4306 SVNGHSELVIERVSKEDSGTYVCTAENSVG 4335



 Score = 98.2 bits (243), Expect = 4e-20
 Identities = 63/245 (25%), Positives = 107/245 (43%), Gaps = 9/245 (3%)

Query: 498  EVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFT--KTPMDLTIR 555
            E+++   +L L+      +G+YQC +SN  G   +   KLT+ + PS        D+++ 
Sbjct: 1502 ELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQ-AKDIKLTIYIPPSIKGGNVTTDISVL 1560

Query: 556  AGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYS 615
              ++ +LEC   G P P I W KDG    P     +   + +     I   ++ D   Y+
Sbjct: 1561 INSLIKLECETRGLPMPAITWYKDGQ---PIMSSSQALYIDKGQYLHIPRAQVSDSATYT 1617

Query: 616  CTAQNSAGSISANATLTVLETPSF---LRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTK 672
            C   N AG+   +  + V   P     L   L++ V    +  L+C A G+P P L W K
Sbjct: 1618 CHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLK 1677

Query: 673  DDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDS 732
            D  P+   +     AG + L I+ +   D G+Y C  ++  G +     + V+  P  + 
Sbjct: 1678 DGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEG 1737

Query: 733  PQMTA 737
               T+
Sbjct: 1738 GDETS 1742



 Score = 97.4 bits (241), Expect = 6e-20
 Identities = 77/297 (25%), Positives = 122/297 (41%), Gaps = 21/297 (7%)

Query: 439  PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 498
            P I  + +  S +    +  +C   S +  P T  W KD   L          L+  G  
Sbjct: 2104 PNIMGEEQNVSVLISQAVELLCQ--SDAIPPPTLTWLKDGHPL----------LKKPGLS 2151

Query: 499  VMEYTTILRLREVEFASEGKYQCVISNHFGSS---YSVKAKLTVNMLPSFTKTPMDLTIR 555
            + E  ++L++ + +    G+Y C  +N  G +   Y+V   +  N+  S   T   LT+ 
Sbjct: 2152 ISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELT--QLTVI 2209

Query: 556  AGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYS 615
             G +  L C + G P P + W+K G      +  R + ++       I   +  D  +YS
Sbjct: 2210 EGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGR-VRILSGGRQLQISIAEKSDAALYS 2268

Query: 616  CTAQNSAGSISANATLTVLETPSFLRPLLDRT---VTKGETAVLQCIAGGSPPPKLNWTK 672
            C A N AG+      L V   P+        T   VT+G++  L+C   G PPP + W K
Sbjct: 2269 CVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMK 2328

Query: 673  DDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729
            D  PL+  +         +L + +  VSD G+Y C   N  G       LSV   P+
Sbjct: 2329 DGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPS 2385



 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 76/303 (25%), Positives = 124/303 (40%), Gaps = 23/303 (7%)

Query: 445  PETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTT 504
            PE  S ++ +++S  C A+      +T  W KD        + N   + + G        
Sbjct: 2393 PENISVVEKNSVSLTCEASGIPLPSIT--WFKDG---WPVSLSNSVRILSGG-------R 2440

Query: 505  ILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFT--KTPMDLTIRAGAMARL 562
            +LRL +      G+Y CV+ N  G    +   L+V + P      T  D+ ++      L
Sbjct: 2441 MLRLMQTTMEDAGQYTCVVRNAAGEERKIFG-LSVLVPPHIVGENTLEDVKVKEKQSVTL 2499

Query: 563  ECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSA 622
             C   G+P P+I W KDG    P   +   H++       I +V++   G Y+C A + A
Sbjct: 2500 TCEVTGNPVPEITWHKDGQ---PLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPA 2556

Query: 623  GSISANATLTVLETPSFLRPLLDR-----TVTKGETAVLQCIAGGSPPPKLNWTKDDSPL 677
            G  S + +L V  +P+      D      TV       L C A   PP  + W KD +PL
Sbjct: 2557 GHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPL 2616

Query: 678  VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQMTA 737
                      G + L I+++   +AG+Y+C  +N  G    +  + V   P  +   +  
Sbjct: 2617 ESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWG 2676

Query: 738  PSL 740
            P L
Sbjct: 2677 PGL 2679



 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 78/297 (26%), Positives = 119/297 (40%), Gaps = 15/297 (5%)

Query: 439  PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 498
            P I   P   + I     +  C A       +   W+K+  LL+  + +N   L + G  
Sbjct: 3804 PSIAPGPTNMTVIVNVQTTLACEATGIPKPSIN--WRKNGHLLNVDQNQNSYRLLSSGSL 3861

Query: 499  VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGA 558
            V+   ++             Y+C ++N  G        LTV + PS    P D  +   A
Sbjct: 3862 VIISPSV--------DDTATYECTVTNGAGDDKRT-VDLTVQVPPSIADEPTDFLVTKHA 3912

Query: 559  MARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTA 618
             A + C A G P P I W K+G    P     R+          I+  ++   G Y+C A
Sbjct: 3913 PAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRIL---SSGAIEILATQLNHAGRYTCVA 3969

Query: 619  QNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLV 678
            +N+AGS   + TL V E P       +  V      +L C A G+P P + W K+   + 
Sbjct: 3970 RNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVN 4029

Query: 679  VTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQM 735
             + R+     +  L I  +   DAG Y C   N  GT  G ++L+V   P   SP +
Sbjct: 4030 TSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNV-QVPPVISPHL 4085



 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 78/318 (24%), Positives = 138/318 (43%), Gaps = 25/318 (7%)

Query: 422  SIFAVSPDGFVCDDFPKPQIT---VQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDN 478
            ++   +   F  D +  P I      P  +  +   +L+  C AA +    +T  W KD 
Sbjct: 1622 NVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILT--WLKDG 1679

Query: 479  ELLHDAEMENYAHLRAQ-GGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKL 537
                   ++   ++R + GG+ +E   I+  +E++    G+Y CV ++  G    +K ++
Sbjct: 1680 -----VPVKANDNIRIEAGGKKLE---IMSAQEID---RGQYICVATSVAGEK-EIKYEV 1727

Query: 538  TVNMLPSFT--KTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVM 595
             V + P+           +    +  L+C   G P P I W KDG             ++
Sbjct: 1728 DVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQL---IDERDGFKIL 1784

Query: 596  PEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRP-LLDRTVTKGETA 654
                   I   ++ + G+Y C A N+AG       +TV   P+     L +R V K +  
Sbjct: 1785 LNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPV 1844

Query: 655  VLQCIAGGSPPPKLNWTKDDSPLVVTERHF-FAAGNQLLIIVDSDVSDAGKYTCEMSNTL 713
             LQCIA G P P + W KDD P+   + +    +  ++L I  + + DAG+YTC  +N  
Sbjct: 1845 ALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAA 1904

Query: 714  GTERGNVRLSVIPTPTCD 731
            G  + +++L V   P+ +
Sbjct: 1905 GETQQHIQLHVHEPPSLE 1922



 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 72/266 (27%), Positives = 121/266 (45%), Gaps = 20/266 (7%)

Query: 469  PMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFG 528
            P T  W KD +L+ + +          G +++     L + + + ++ G Y+C+ +N  G
Sbjct: 1763 PPTIMWLKDGQLIDERD----------GFKILLNGRKLVIAQAQVSNTGLYRCMAANTAG 1812

Query: 529  SSYSVKAKLTVNMLPSFTKTPMD--LTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPA 586
              +  + ++TV++ P+   + +   + ++   +A L+C A G P P I W KD   D P 
Sbjct: 1813 D-HKKEFEVTVHVPPTIKSSGLSERVVVKYKPVA-LQCIANGIPNPSITWLKD---DQPV 1867

Query: 587  -ARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSF--LRPL 643
               +  + +     V  I    +ED G Y+C A N+AG    +  L V E PS      +
Sbjct: 1868 NTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKM 1927

Query: 644  LDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAG 703
            L+ TV       L+C A G+P P + W KD+  L  +    F    Q++ I  + +SDAG
Sbjct: 1928 LNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAG 1987

Query: 704  KYTCEMSNTLGTERGNVRLSVIPTPT 729
             Y C   N+ G       L V   P+
Sbjct: 1988 IYKCVAINSAGATELFYSLQVHVAPS 2013



 Score = 94.0 bits (232), Expect = 7e-19
 Identities = 79/307 (25%), Positives = 122/307 (39%), Gaps = 36/307 (11%)

Query: 439  PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLH------DAEMENYAHL 492
            P I    +  S I+G  ++  C A  S +   +  W K  EL+        A  +   ++
Sbjct: 981  PTIQHGQQILSTIEGIPVTLPCKA--SGNPKPSVIWSKKGELISTSSAKFSAGADGSLYV 1038

Query: 493  RAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSF------- 545
             + GGE                  G+Y C  +N  G +   K +LTV + P         
Sbjct: 1039 VSPGGE----------------ESGEYVCTATNTAGYAKR-KVQLTVYVRPRVFGDQRGL 1081

Query: 546  -TKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIV 604
                P+++++ AG    L C     P P I W K+     P +     H         I 
Sbjct: 1082 SQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPR---HTFLPSGSMKIT 1138

Query: 605  DVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSP 664
            + +  D G+Y C A N AG+++    L V   P   R      V  G+   + C A G+P
Sbjct: 1139 ETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTP 1198

Query: 665  PPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSV 724
             P + W+K  S ++V   H  +  +  L I  +  SDAG YTC  +N  GT+   + L V
Sbjct: 1199 LPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHV 1258

Query: 725  IPTPTCD 731
               PT +
Sbjct: 1259 QEPPTVE 1265



 Score = 93.6 bits (231), Expect = 9e-19
 Identities = 72/269 (26%), Positives = 113/269 (42%), Gaps = 27/269 (10%)

Query: 474  WKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSV 533
            W KD + L + E    AH    GG  ++ T       V+    G+Y C+ S+  G   S 
Sbjct: 2513 WHKDGQPLQEDE----AHHIISGGRFLQITN------VQVPHTGRYTCLASSPAGHK-SR 2561

Query: 534  KAKLTVNMLPSFTKT-----PMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAAR 588
               L V + P+         P D+T+   +   L C A  +P   I W KDG    P   
Sbjct: 2562 SFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGT---PLES 2618

Query: 589  ERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLL---- 644
             R + ++P      I++ + ++ G YSC A N AG +  +  + V   P   +  L    
Sbjct: 2619 NRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPG 2678

Query: 645  ----DRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVS 700
                +  +    T  L+C A   P   L+W KD  PL   +    AA    L I ++ +S
Sbjct: 2679 LSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQIS 2738

Query: 701  DAGKYTCEMSNTLGTERGNVRLSVIPTPT 729
            D G+YTC  SN  G +  +  +++   P+
Sbjct: 2739 DTGRYTCVASNIAGEDELDFDVNIQVPPS 2767



 Score = 93.2 bits (230), Expect = 1e-18
 Identities = 67/218 (30%), Positives = 93/218 (42%), Gaps = 5/218 (2%)

Query: 517  GKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAW 576
            G+Y CV  N  GS++     L V+  P     P +L +       L C A G P+P I W
Sbjct: 3963 GRYTCVARNAAGSAHR-HVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITW 4021

Query: 577  QKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLET 636
            QK+G     + R     V+P   +     V+ ED G Y C AQN AG+      L V   
Sbjct: 4022 QKEGINVNTSGRNHA--VLPSGGLQISRAVR-EDAGTYMCVAQNPAGTALGKIKLNVQVP 4078

Query: 637  PSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVD 696
            P     L +  +   +   L C A G PPP + W KD   +V + R    +   L I   
Sbjct: 4079 PVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAF- 4137

Query: 697  SDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQ 734
                DAG YTC  +N  G+   + +L+V   P   S +
Sbjct: 4138 VQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTE 4175



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 63/228 (27%), Positives = 98/228 (42%), Gaps = 7/228 (3%)

Query: 505  ILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSF--TKTPMDLTIRAGAMARL 562
            IL+L        G+Y C   N  G+S      + V + P+   T  P ++++       L
Sbjct: 1415 ILKLFRATPEDAGRYSCKAINIAGTSQKY-FNIDVLVPPTIIGTNFPNEVSVVLNRDVAL 1473

Query: 563  ECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSA 622
            EC   G P P I W KDG   F    +  + ++    V  + + +  D G Y CT  N+A
Sbjct: 1474 ECQVKGTPFPDIHWFKDGKPLFLG--DPNVELLDRGQVLHLKNARRNDKGRYQCTVSNAA 1531

Query: 623  GSISANATLTVLETPSFL--RPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVT 680
            G  + +  LT+   PS        D +V       L+C   G P P + W KD  P++ +
Sbjct: 1532 GKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSS 1591

Query: 681  ERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728
             +  +    Q L I  + VSD+  YTC ++N  GT   +  + V   P
Sbjct: 1592 SQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPP 1639



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 65/244 (26%), Positives = 104/244 (42%), Gaps = 12/244 (4%)

Query: 505 ILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLEC 564
           +L+++E +    G Y CV  N  G +   K  L V   P F + P D+++  G+   L C
Sbjct: 756 LLKIQETQDLDAGDYTCVAINEAGRATG-KITLDVGSPPVFIQEPADVSMEIGSNVTLPC 814

Query: 565 AAVGHPAPQIAWQK-DGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAG 623
              G+P P I W++ D    F                 FI+++   D G Y C A+N  G
Sbjct: 815 YVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFG 874

Query: 624 SISANATLTVLETPSFLRPLLD-----RTVTKGETAVLQC-IAGGSPPPKLNWTKDDSPL 677
            I +  T+TV      + PL+        V +G+   L C +  G+P P+  W K+ S +
Sbjct: 875 KIQSETTVTVT---GLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKN-SAM 930

Query: 678 VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQMTA 737
           ++   +     +  L I    + D G+YTC  SN  GT      + V   PT    Q   
Sbjct: 931 LLQNPYITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQIL 990

Query: 738 PSLD 741
            +++
Sbjct: 991 STIE 994



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 71/290 (24%), Positives = 119/290 (41%), Gaps = 21/290 (7%)

Query: 439 PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 498
           P++TV P+ QS   GS +S +CSA       +  AW  ++  +    + ++ +     G 
Sbjct: 612 PKVTVMPKNQSFTGGSEVSIMCSATGYPKPKI--AWTVNDMFI----VGSHRYRMTSDGT 665

Query: 499 VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGA 558
           +        ++       G Y C+ SN  G+     + L     P       +L +  G 
Sbjct: 666 LF-------IKNAAPKDAGIYGCLASNSAGTDKQ-NSTLRYIEAPKLMVVQSELLVALGD 717

Query: 559 MARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTA 618
           +  +EC   G P PQ+ W K    D        + + P   +  I + +  D G Y+C A
Sbjct: 718 ITVMECKTSGIPPPQVKWFKG---DLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVA 774

Query: 619 QNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLV 678
            N AG  +   TL V   P F++   D ++  G    L C   G P P + W + D+  +
Sbjct: 775 INEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPI 834

Query: 679 VTERHFFAAGNQL----LIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSV 724
            +     ++ +QL    L I++   SD G Y CE  N  G  +    ++V
Sbjct: 835 FSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTV 884



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 74/306 (24%), Positives = 125/306 (40%), Gaps = 23/306 (7%)

Query: 430  GFVCDDFPKPQITVQ-PETQSAIKGSNLSFICSAASSSDSPMTFAWKK-DNELLHDA--E 485
            G +  D   P + +Q P   S   GSN++  C      +   T  W++ DN  +      
Sbjct: 783  GKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEP--TIKWRRLDNMPIFSRPFS 840

Query: 486  MENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNML--P 543
            + + + LR         T  L +  +  + +G Y C   N FG   S +  +TV  L  P
Sbjct: 841  VSSISQLR---------TGALFILNLWASDKGTYICEAENQFGKIQS-ETTVTVTGLVAP 890

Query: 544  SFTKTPMDLTIRAGAMARLECAAV-GHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFF 602
                +P    +  G    L C  + G+P P+  W K+         +     +  D    
Sbjct: 891  LIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAM----LLQNPYITVRSDGSLH 946

Query: 603  IVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGG 662
            I  V+++D G Y+C A N AG+ +   ++ V   P+        +  +G    L C A G
Sbjct: 947  IERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASG 1006

Query: 663  SPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRL 722
            +P P + W+K    +  +   F A  +  L +V     ++G+Y C  +NT G  +  V+L
Sbjct: 1007 NPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQL 1066

Query: 723  SVIPTP 728
            +V   P
Sbjct: 1067 TVYVRP 1072



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 72/300 (24%), Positives = 113/300 (37%), Gaps = 33/300 (11%)

Query: 450  AIKGSNL---------SFICSAASSSDSPM-TFAWKKDNELLHDAEMENYAHLRAQGGEV 499
            +IKG N+         S I     +   PM    W KD + +  +    Y          
Sbjct: 1547 SIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQALY---------- 1596

Query: 500  MEYTTILRLREVEFASEGKYQCVISNHFGS---SYSVKAKLTVNMLPSFTKTPMDLTIRA 556
            ++    L +   + +    Y C ++N  G+   S+ V   +   M+     TP++  +  
Sbjct: 1597 IDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPP-MIEGNLATPLNKQVVI 1655

Query: 557  GAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSC 616
                 LEC A G+P+P + W KDG    P      + +        I+  +  D G Y C
Sbjct: 1656 AHSLTLECKAAGNPSPILTWLKDG---VPVKANDNIRIEAGGKKLEIMSAQEIDRGQYIC 1712

Query: 617  TAQNSAGSISANATLTVLETPSFLRPLLDRT----VTKGETAVLQCIAGGSPPPKLNWTK 672
             A + AG       + VL  P+      D T    V       L C   GSPPP + W K
Sbjct: 1713 VATSVAGEKEIKYEVDVLVPPAIEGG--DETSYFIVMVNNLLELDCHVTGSPPPTIMWLK 1770

Query: 673  DDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDS 732
            D   +   +        + L+I  + VS+ G Y C  +NT G  +    ++V   PT  S
Sbjct: 1771 DGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKS 1830



 Score = 74.7 bits (182), Expect = 4e-13
 Identities = 68/278 (24%), Positives = 103/278 (37%), Gaps = 21/278 (7%)

Query: 439  PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 498
            P  T  P   S  KG  L   C A       +T  W  +N ++        AH  +  G 
Sbjct: 4260 PTFTELPGDVSLNKGEQLRLSCKATGIPLPKLT--WTFNNNIIP-------AHFDSVNGH 4310

Query: 499  VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKT-PMDLTIRAG 557
                 + L +  V     G Y C   N  G   ++   + V   P F    P +     G
Sbjct: 4311 -----SELVIERVSKEDSGTYVCTAENSVGFVKAI-GFVYVKEPPVFKGDYPSNWIEPLG 4364

Query: 558  AMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCT 617
              A L C   G P P I W + G     + R R++     +    I     ED G Y+C 
Sbjct: 4365 GNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLG----NGSLAIYGTVNEDAGDYTCV 4420

Query: 618  AQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPL 677
            A N AG +  + +LT+   P      ++  +  G   +L C A G P P + W++    +
Sbjct: 4421 ATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSI 4480

Query: 678  VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGT 715
               +R      N  L I D+   D  ++ C   N +G+
Sbjct: 4481 SWDDR-VNVLSNNSLYIADAQKEDTSEFECVARNLMGS 4517



 Score = 67.0 bits (162), Expect = 9e-11
 Identities = 70/298 (23%), Positives = 117/298 (39%), Gaps = 22/298 (7%)

Query: 439  PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 498
            P+I   P+      G  +   C+A  +    +T++ K  + +L D E     H+    G 
Sbjct: 1171 PKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWS-KGGSTMLVDGEH----HVSNPDGT 1225

Query: 499  VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFT--KTPMDLTIR- 555
                   L + +   +  G Y CV +N  G+    +  L V   P+    + P + T + 
Sbjct: 1226 -------LSIDQATPSDAGIYTCVATNIAGTD-ETEITLHVQEPPTVEDLEPPYNTTFQE 1277

Query: 556  --AGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGV 613
              A       C A G P P I W  +G       RE  + ++ +  +  I  V   D G 
Sbjct: 1278 RVANQRIEFPCPAKGTPKPTIKWLHNGRE--LTGREPGISILEDGTLLVIASVTPYDNGE 1335

Query: 614  YSCTAQNSAGSISANATLTVLETPSFL--RPLLDRTVTKGETAVLQCIAGGSPPPKLNWT 671
            Y C A N AG+      L V   P       + + +V   +   L C   G+P P + W 
Sbjct: 1336 YICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWY 1395

Query: 672  KDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729
            KD+  +  +         ++L +  +   DAG+Y+C+  N  GT +    + V+  PT
Sbjct: 1396 KDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPT 1453



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 55/216 (25%), Positives = 92/216 (42%), Gaps = 17/216 (7%)

Query: 603 IVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGG 662
           I  V + D G Y C A +SAG+  A     V E P  ++   + TVT GE AVL C+   
Sbjct: 486 IAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPPVIQVPNNVTVTPGERAVLTCLIIS 545

Query: 663 SPPPKLNWTKDDSPLVVTE-RHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVR 721
           +    L W ++D  + + E        N  L +     +DAG+Y C +S+  G+   +V 
Sbjct: 546 AVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGSSAASVF 605

Query: 722 LSVIPTPTCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVG---TSLVWVV-----IIYHT 773
           L+V      + P++T    +    +  G   ++++C   G     + W V     +  H 
Sbjct: 606 LTV-----QEPPKVTVMPKNQ---SFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHR 657

Query: 774 RRRNEDCSITNTDETNLPADIPSYLSSQGTLADRQD 809
            R   D ++   +     A I   L+S     D+Q+
Sbjct: 658 YRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQN 693



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 35/117 (29%), Positives = 54/117 (46%), Gaps = 5/117 (4%)

Query: 517  GKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAW 576
            G Y CV +N  G        LT+   P  T  P++  I AG    L C A G P P I W
Sbjct: 4415 GDYTCVATNEAGV-VERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITW 4473

Query: 577  QKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTV 633
             + G +    + + R++V+  + ++ I D + ED   + C A+N  GS+     + V
Sbjct: 4474 SRQGHS---ISWDDRVNVLSNNSLY-IADAQKEDTSEFECVARNLMGSVLVRVPVIV 4526


>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
          Length = 653

 Score =  121 bits (304), Expect = 3e-27
 Identities = 104/375 (27%), Positives = 171/375 (45%), Gaps = 21/375 (5%)

Query: 158 QHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTE 217
           ++L L  N I+ +   TF+ L  L+ L++ RN + ++  GAF GL+++  L+L  N LT 
Sbjct: 78  RYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTV 137

Query: 218 ITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDL-TFNHLSRLDDSSFLGLSL 276
           I  G    L  L+EL L  N I  I   A+     L  LDL     L  + + +F GL  
Sbjct: 138 IPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFN 197

Query: 277 LNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGN 336
           L  L++G   +  + +     L  L+ L++  N      E   G+F GL  L++L +  +
Sbjct: 198 LKYLNLGMCNIKDMPNLT--PLVGLEELEMSGNHFP---EIRPGSFHGLSSLKKLWVMNS 252

Query: 337 RIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLP 396
           ++  I + AF GL +L  L+L+ N + SL  + F+ ++ L +LHL+ +   CDC + WL 
Sbjct: 253 QVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWLA 312

Query: 397 QWVAEN-NFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSN 455
            W+ E     S     C  P  ++GR +  V    F C     P I   P   +  +G  
Sbjct: 313 WWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQASFQCS---APFIMDAPRDLNISEGRM 369

Query: 456 LSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFAS 515
               C     S    +  W     LL +  + ++A    +   + + T  L    V  + 
Sbjct: 370 AELKCRTPPMS----SVKW-----LLPNGTVLSHASRHPRISVLNDGT--LNFSHVLLSD 418

Query: 516 EGKYQCVISNHFGSS 530
            G Y C+++N  G+S
Sbjct: 419 TGVYTCMVTNVAGNS 433



 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 62/222 (27%), Positives = 93/222 (41%), Gaps = 48/222 (21%)

Query: 20  DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPE 79
           +L  N L+ I + +  +L  LRE+ L NN +E+IP            S A NR+  ++  
Sbjct: 129 ELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIP------------SYAFNRVPSLMRL 176

Query: 80  HLKEFQSLETLDLSSNNISELQTAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVLK 138
            L E + LE +          + AF  L  LKYL L    +  M                
Sbjct: 177 DLGELKKLEYIS---------EGAFEGLFNLKYLNLGMCNIKDM---------------- 211

Query: 139 LNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGA 198
                     P +  L  L+ LE++ N    +   +F GL +LK L +  + V+ +   A
Sbjct: 212 ----------PNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNA 261

Query: 199 FWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAIN 240
           F GL+++  L L HNNL+ +       L  L ELHL  N  N
Sbjct: 262 FDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWN 303



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 71/272 (26%), Positives = 107/272 (39%), Gaps = 47/272 (17%)

Query: 543 PSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFP-AARERRMHVMPEDDVF 601
           P     P DL I  G MA L+C     P   + W    GT    A+R  R+ V+ +  + 
Sbjct: 353 PFIMDAPRDLNISEGRMAELKCRTP--PMSSVKWLLPNGTVLSHASRHPRISVLNDGTLN 410

Query: 602 FIVDVKIEDIGVYSCTAQNSAGSISANATLTV----LETPSFLRPLLDRTVTKGETAVLQ 657
           F   V + D GVY+C   N AG+ +A+A L V    L T ++       TVT   T +  
Sbjct: 411 FS-HVLLSDTGVYTCMVTNVAGNSNASAYLNVSTAELNTSNY---SFFTTVTVETTEI-- 464

Query: 658 CIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTER 717
                SP    + T+   P+  T   +  A                 YT   +  + T R
Sbjct: 465 -----SPE---DTTRKYKPVPTTSTGYQPA-----------------YTTSTTVLIQTTR 499

Query: 718 GNVRLSVIPTPTCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRN 777
              +++V  T T D  Q    SLD+    T   +II     V   +   +++ Y  R+R+
Sbjct: 500 VPKQVAVPATDTTDKMQ---TSLDEVMKTT--KIIIGCFVAVTLLAAAMLIVFYKLRKRH 554

Query: 778 EDCSITNTDET----NLPADIPSYLSSQGTLA 805
           +  S      T     +  DIP+  S+  T A
Sbjct: 555 QQRSTVTAARTVEIIQVDEDIPAATSAAATAA 586


>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3874

 Score =  120 bits (302), Expect = 5e-27
 Identities = 86/291 (29%), Positives = 129/291 (44%), Gaps = 15/291 (5%)

Query: 439 PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 498
           P I   P  ++ ++ ++++  C A  S   P   +W K ++ +              G  
Sbjct: 695 PNIEPGPVNKAVLENASVTLECLA--SGVPPPDVSWFKGHQPVSSW----------MGVT 742

Query: 499 VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTP-MDLTIRAG 557
           V     +LR+ + + +  G Y+CV SN  GS+  ++  L VN+ P  T  P +   +   
Sbjct: 743 VSVDGRVLRIEQAQLSDAGSYRCVASNVAGST-ELRYGLRVNVPPRITLPPSLPGPVLVN 801

Query: 558 AMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCT 617
              RL C A G P+P + W KDG    PA     + V P   V  +   +  D G YSC 
Sbjct: 802 TPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPG-LQVFPGGRVLTLASARASDSGRYSCV 860

Query: 618 AQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPL 677
           A ++ G    +  L V   PS L   L+ +V   E+  L+C +   PPP L+W KD  PL
Sbjct: 861 AVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPL 920

Query: 678 VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728
                   +A   LL +  +DV DAG YTCE  N  G    +  L+V   P
Sbjct: 921 EPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVAP 971



 Score =  114 bits (285), Expect = 5e-25
 Identities = 77/269 (28%), Positives = 120/269 (44%), Gaps = 18/269 (6%)

Query: 473  AWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYS 532
            +W+KD + L   E     H+ A G        +L L + + A EG Y C  SN  G+S S
Sbjct: 1004 SWRKDGQPL-PGEGAGLQHVSAVG-------RLLYLGQAQLAQEGTYTCECSNVVGNS-S 1054

Query: 533  VKAKLTVNMLPSFT---KTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARE 589
               +L V++ P      + P  +++    +A LEC A G P P + W++DG    P   E
Sbjct: 1055 QDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQ---PVGAE 1111

Query: 590  RRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSF---LRPLLDR 646
              + +  +     +   +    G YSC A+N AG       L+VL  P     L PL + 
Sbjct: 1112 LGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNI 1171

Query: 647  TVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYT 706
            T        L C A G PPP + W + + P+   E  +  AG  +L +  +   D+G Y+
Sbjct: 1172 TAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYS 1231

Query: 707  CEMSNTLGTERGNVRLSVIPTPTCDSPQM 735
            C  SN  G  R N  + V+  P+ ++  +
Sbjct: 1232 CLASNEAGEARRNFSVEVLVPPSIENEDL 1260



 Score =  106 bits (265), Expect = 1e-22
 Identities = 83/292 (28%), Positives = 133/292 (45%), Gaps = 22/292 (7%)

Query: 444  QPETQ-SAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEY 502
            +P TQ S ++    +  C+A      P T  W++D + +  AE+         G ++   
Sbjct: 1072 EPPTQVSVVQDGVATLECNATGKP--PPTVTWERDGQPV-GAEL---------GLQLQNQ 1119

Query: 503  TTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAM--- 559
               L +   + A  G+Y CV  N  G +   K +L+V + P        LT    A+   
Sbjct: 1120 GQSLHVERAQAAHTGRYSCVAENLAGRAER-KFELSVLVPPELIGDLDPLTNITAALHSP 1178

Query: 560  ARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQ 619
              L C A+G P P I W +    + P +     +++    +  +   + +D G+YSC A 
Sbjct: 1179 LTLLCEAMGIPPPAIRWFRG---EEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLAS 1235

Query: 620  NSAGSISANATLTVLETPSFLRPLLDRT--VTKGETAVLQCIAGGSPPPKLNWTKDDSPL 677
            N AG    N ++ VL  PS     L+    V  G+TA L C   G P PKL W KD  PL
Sbjct: 1236 NEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPL 1295

Query: 678  VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729
               + H  +    LL ++ +++S AG Y+C  +N +G +  + +LSV+  PT
Sbjct: 1296 ARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPT 1347



 Score =  106 bits (265), Expect = 1e-22
 Identities = 71/242 (29%), Positives = 111/242 (45%), Gaps = 9/242 (3%)

Query: 498  EVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMD-LTIRA 556
            +V+E   +L++   E A    Y CV  N  GS+  +   L V + P      ++ +T   
Sbjct: 1702 QVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFT-LRVQVPPRIAGLDLEQVTAIL 1760

Query: 557  GAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSC 616
             +   L C    HP P++ W KD       +    + ++P      +   ++ D G+Y+C
Sbjct: 1761 NSSVSLPCDVHAHPNPEVTWYKDSQA---LSLGEEVFLLPGTHTLQLGRARLSDSGMYTC 1817

Query: 617  TAQNSAGSISANATLTVLETPSFLR----PLLDRTVTKGETAVLQCIAGGSPPPKLNWTK 672
             A N+AG       L+VL  P+F +    P     V  G+ AVL C     P P + W K
Sbjct: 1818 EALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYK 1877

Query: 673  DDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDS 732
            D  PLV+ +R     G Q L I ++ VSD G Y+C++SN  G       L+V   PT ++
Sbjct: 1878 DGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFEN 1937

Query: 733  PQ 734
            P+
Sbjct: 1938 PK 1939



 Score =  106 bits (264), Expect = 1e-22
 Identities = 69/234 (29%), Positives = 107/234 (45%), Gaps = 15/234 (6%)

Query: 505  ILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNML--PSFTKTPMDLTIRA--GAMA 560
            +L++ + +    G Y C+ SN  G +   +   +V +L  PS     ++  I+   G  A
Sbjct: 1216 MLKMTQTQEQDSGLYSCLASNEAGEA---RRNFSVEVLVPPSIENEDLEEVIKVLDGQTA 1272

Query: 561  RLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQN 620
             L C   GHP P++ W KDG    P AR    H+ P+  +  ++   +   G YSC A N
Sbjct: 1273 HLMCNVTGHPQPKLTWFKDGR---PLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAAN 1329

Query: 621  SAGSISANATLTVLETPSFLRPLLDR-----TVTKGETAVLQCIAGGSPPPKLNWTKDDS 675
            + G  + +  L+VL  P+ L    D      TVT      L C A   P P + W KD +
Sbjct: 1330 AVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGA 1389

Query: 676  PLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729
            P   +       G   L I+++   DAG+YTC ++N LG    N  + V+  P+
Sbjct: 1390 PFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPS 1443



 Score =  105 bits (261), Expect = 3e-22
 Identities = 122/478 (25%), Positives = 184/478 (38%), Gaps = 75/478 (15%)

Query: 386  LLCDCQLKWLPQ--WVAENNFQSFVNASCAHPQLLKGR-----SIFAVSPDGFVCDDF-- 436
            LLCD Q    P   W  +    + +  +    ++L+ R     +  A SP G +   F  
Sbjct: 2324 LLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRV 2383

Query: 437  --PKPQITVQPETQSAIKG---SNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAH 491
                P   V P     + G     L   CS  +     +T  W +D  +L +      AH
Sbjct: 2384 RVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKIT--WHRDGIVLQED-----AH 2436

Query: 492  LRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMD 551
                  +  E    L+L+ +  A  G Y C   N  GS+ SV  ++ ++ +P+    P  
Sbjct: 2437 T-----QFPERGRFLQLQALSTADSGDYSCTARNAAGST-SVAFRVEIHTVPTIRSGPPA 2490

Query: 552  LTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDI 611
            + +     A L C A G PAP ++W+KD     P  R  R  ++PE  +  I  V  +D 
Sbjct: 2491 VNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDP--RSPRFEILPEGSLR-IQPVLAQDA 2547

Query: 612  GVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWT 671
            G Y C A NSAGS      L VLE P+      + T+T    A+L C A GSP P + W 
Sbjct: 2548 GHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWW 2607

Query: 672  KDDSPL--VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729
            KD   L   + +  +    +  L++      D+ ++ C +SN +G      +++V   PT
Sbjct: 2608 KDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPT 2667

Query: 730  CDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETN 789
                       DD    TV ++   V+ C                             T 
Sbjct: 2668 I---------ADDQTDFTVTMMAPVVLTC---------------------------HSTG 2691

Query: 790  LPADIPSYLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSGTCHIDNSS 847
            +PA   S+  +   L  R  GY  S SG+          G  LP H    TC   NS+
Sbjct: 2692 IPAPTVSWSKAGAQLGARGSGYRVSPSGALE-------IGQALPIHAGRYTCSARNSA 2742



 Score =  104 bits (260), Expect = 4e-22
 Identities = 67/209 (32%), Positives = 97/209 (46%), Gaps = 6/209 (2%)

Query: 506  LRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECA 565
            LR+        G Y C+  N  GS+   K +L V + P       DL+   G+ A L C 
Sbjct: 2811 LRIAHASPEDAGNYLCIAKNSAGSAMG-KTRLVVQVPPVIENGLPDLSTTEGSHAFLPCK 2869

Query: 566  AVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSI 625
            A G P P I W KDG     +  E +  + P  ++  + +++ +D G Y+CTA+N+ G  
Sbjct: 2870 ARGSPEPNITWDKDGQP--VSGAEGKFTIQPSGELL-VKNLEGQDAGTYTCTAENAVGRA 2926

Query: 626  SANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFF 685
                 LT+L  P F     DR++  G+   L+C A GSP P++ WT +D P  VTE    
Sbjct: 2927 RRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRP--VTEGVSE 2984

Query: 686  AAGNQLLIIVDSDVSDAGKYTCEMSNTLG 714
              G   L        D+G Y C   N +G
Sbjct: 2985 QDGGSTLQRAAVSREDSGTYVCWAENRVG 3013



 Score =  104 bits (259), Expect = 5e-22
 Identities = 71/212 (33%), Positives = 92/212 (43%), Gaps = 5/212 (2%)

Query: 517  GKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAW 576
            G+Y C   N  G ++     LTV   P     P  +   A     L C A G P P I W
Sbjct: 2732 GRYTCSARNSAGVAHK-HVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITW 2790

Query: 577  QKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLET 636
            QK+G      A      V+P   +  I     ED G Y C A+NSAGS      L V   
Sbjct: 2791 QKEG---LNVATGVSTQVLPGGQLR-IAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVP 2846

Query: 637  PSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVD 696
            P     L D + T+G  A L C A GSP P + W KD  P+   E  F    +  L++ +
Sbjct: 2847 PVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKN 2906

Query: 697  SDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728
             +  DAG YTC   N +G  R  V L+++  P
Sbjct: 2907 LEGQDAGTYTCTAENAVGRARRRVHLTILVLP 2938



 Score = 93.2 bits (230), Expect = 1e-18
 Identities = 83/294 (28%), Positives = 125/294 (42%), Gaps = 25/294 (8%)

Query: 446  ETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTI 505
            ET S + GS L   C   S   +P T  W KD   +  + +       ++GG        
Sbjct: 1941 ETVSQVAGSPLVLTCDV-SGVPAP-TVTWLKDRMPVESSAVHGVV---SRGGR------- 1988

Query: 506  LRLREVEFASEGKYQCVISNHFGSSYS--VKAKLTVNMLPSFTKTPMDLTIRAGAMARLE 563
            L+L  ++ A  G Y CV  N    +    V A L    + S +    +  +  G   RL+
Sbjct: 1989 LQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRS-SGVAREHHVLEGQEVRLD 2047

Query: 564  CAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIV--DVKIEDIGVYSCTAQNS 621
            C A G P P +AW KDG    P  ++   H+    D   +V   ++  D G Y+C A N 
Sbjct: 2048 CEADGQPPPDVAWLKDGS---PLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNP 2104

Query: 622  AGSISANATLTVLETPSFLRPLLDRTVT----KGETAVLQCIAGGSPPPKLNWTKDDSPL 677
            AG  +   T+ VL  P+ ++   D + T     GE   + C   GSPP  ++W KD  PL
Sbjct: 2105 AGEDARLHTVNVLVPPT-IKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPL 2163

Query: 678  VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCD 731
             +++R         L I    ++DAG +TC  ++  G    N  L V   P  +
Sbjct: 2164 PLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVLE 2217



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 69/227 (30%), Positives = 101/227 (44%), Gaps = 7/227 (3%)

Query: 506 LRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECA 565
           L++ +V+   EG Y C  +N  G S    A L V + P+    P++  +   A   LEC 
Sbjct: 659 LQIEKVDLRDEGIYTCAATNLAGESKREVA-LKVLVPPNIEPGPVNKAVLENASVTLECL 717

Query: 566 AVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSI 625
           A G P P ++W K      P +    + V  +  V  I   ++ D G Y C A N AGS 
Sbjct: 718 ASGVPPPDVSWFKGHQ---PVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGST 774

Query: 626 SANATLTVLETPSF-LRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPL--VVTER 682
                L V   P   L P L   V       L C A G+P P L W KD +P+    T  
Sbjct: 775 ELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPG 834

Query: 683 HFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729
                G ++L +  +  SD+G+Y+C   + +G +R +V L V   P+
Sbjct: 835 LQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPS 881



 Score = 90.9 bits (224), Expect = 6e-18
 Identities = 78/272 (28%), Positives = 120/272 (44%), Gaps = 18/272 (6%)

Query: 463  ASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCV 522
            AS S  P+   WK   +L  D  ++       QG   +  +  L L         +++CV
Sbjct: 2596 ASGSPKPLVVWWKDGQKL--DFRLQ-------QGAYRLLPSNALLLTAPGPQDSAQFECV 2646

Query: 523  ISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGT 582
            +SN  G ++ +  ++TV++ P+      D T+   A   L C + G PAP ++W K G  
Sbjct: 2647 VSNEVGEAHRLY-QVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQ 2705

Query: 583  DFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRP 642
                AR     V P   +     + I   G Y+C+A+NSAG    +  LTV  +P  ++P
Sbjct: 2706 --LGARGSGYRVSPSGALEIGQALPIH-AGRYTCSARNSAGVAHKHVFLTVQASP-VVKP 2761

Query: 643  L--LDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVS 700
            L  + R V + E  +L C A G P P + W K+   +          G QL I   +   
Sbjct: 2762 LPSVVRAVAE-EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRI-AHASPE 2819

Query: 701  DAGKYTCEMSNTLGTERGNVRLSVIPTPTCDS 732
            DAG Y C   N+ G+  G  RL V   P  ++
Sbjct: 2820 DAGNYLCIAKNSAGSAMGKTRLVVQVPPVIEN 2851



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 76/294 (25%), Positives = 112/294 (38%), Gaps = 18/294 (6%)

Query: 439  PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 498
            P I  +    S +   +++  C   S +  P   +W KD   L   E     HL A    
Sbjct: 880  PSILGEELNVSVVANESVALECQ--SHAMPPPVLSWWKDGRPL---EPRPGVHLSAD--- 931

Query: 499  VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFT-KTPMDLTIRAG 557
                  +L++   +    G Y C   N  G S      L V + P F  +    LT+R G
Sbjct: 932  ----KALLQVDRADVWDAGHYTCEALNQAGRSEK-HYNLNVWVAPVFPLRESHTLTVREG 986

Query: 558  AMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCT 617
                L C   G P P+I+W+KD G   P       HV     + ++   ++   G Y+C 
Sbjct: 987  HPTSLSCECRGVPFPKISWRKD-GQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCE 1045

Query: 618  AQNSAGSISANATLTVLETPSFLRPLLDRT---VTKGETAVLQCIAGGSPPPKLNWTKDD 674
              N  G+ S +  L V   P    P    T   V +   A L+C A G PPP + W +D 
Sbjct: 1046 CSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDG 1105

Query: 675  SPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728
             P+            Q L +  +  +  G+Y+C   N  G       LSV+  P
Sbjct: 1106 QPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPP 1159



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 74/300 (24%), Positives = 120/300 (40%), Gaps = 43/300 (14%)

Query: 456  LSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFAS 515
            +S IC A +     +T  W KD      A  E   +++   G     T  L++   +   
Sbjct: 1368 ISLICEALAFPSPNIT--WMKDG-----APFEASRNIQLLPG-----THGLQILNAQKED 1415

Query: 516  EGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTP-------MDLTIRAGAMARLECAAVG 568
             G+Y CV++N  G +      + V + PS +K          ++  +  +   LEC +  
Sbjct: 1416 AGQYTCVVTNELGEAVK-NYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWA 1474

Query: 569  HPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISAN 628
             P P I W KDG    P     R+ V+ E  +  I   ++ D G Y C A N AG    +
Sbjct: 1475 VPPPTIRWYKDGQ---PVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQD 1531

Query: 629  ATLTVLETPSFLR--------PLLDRT------------VTKGETAVLQCIAGGSPPPKL 668
              + +   P F +         +L R             + +   A L C     PPP L
Sbjct: 1532 FNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDL 1591

Query: 669  NWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728
             W ++D PL   +      G ++L I      +AG+Y+C+ SN +G +  +  L V+  P
Sbjct: 1592 TWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPP 1651



 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 62/223 (27%), Positives = 95/223 (42%), Gaps = 2/223 (0%)

Query: 506  LRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECA 565
            LR++ V     G Y C+ SN  GS    +  L V   P+   +P +LT+ A   A L C 
Sbjct: 2537 LRIQPVLAQDAGHYLCLASNSAGSDRQGR-DLRVLEPPAIAPSPSNLTLTAHTPALLPCE 2595

Query: 566  AVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSI 625
            A G P P + W KDG       ++    ++P + +        +D   + C   N  G  
Sbjct: 2596 ASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGP-QDSAQFECVVSNEVGEA 2654

Query: 626  SANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFF 685
                 +TV   P+      D TVT     VL C + G P P ++W+K  + L      + 
Sbjct: 2655 HRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYR 2714

Query: 686  AAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728
             + +  L I  +    AG+YTC   N+ G    +V L+V  +P
Sbjct: 2715 VSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASP 2757



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 82/311 (26%), Positives = 121/311 (38%), Gaps = 26/311 (8%)

Query: 425 AVSPDGFVCDDFP-----KPQITVQPET-QSAIKGSNLSFICSAASSSDSPMTFAWKKDN 478
           A SP G    DF       P I    ET + A+   +L  +   A    +P    W KD 
Sbjct: 291 AFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTP-NITWFKDG 349

Query: 479 ELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLT 538
            LL  +    Y     +GG        L+L   + +  G Y C  SN  G++     +L 
Sbjct: 350 ALLPTSTKVVYT----RGGRQ------LQLGRAQSSDAGVYTCKASNAVGAAEKA-TRLD 398

Query: 539 VNMLPSFTKT---PMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVM 595
           V + P+       P  +   AG    LEC A GHP+P ++W  +G    P A      + 
Sbjct: 399 VYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEG---LPVAESNESRLE 455

Query: 596 PEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFL--RPLLDRTVTKGET 653
            +  V  +        G+YSC A + AG      ++ V   P  L    L   T   G+ 
Sbjct: 456 TDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQP 515

Query: 654 AVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTL 713
             L C A GSP P + W ++  P         A+    L I   ++  +G + C+ +N  
Sbjct: 516 LELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEA 575

Query: 714 GTERGNVRLSV 724
           GT    V +SV
Sbjct: 576 GTAGAEVEVSV 586



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 83/320 (25%), Positives = 124/320 (38%), Gaps = 40/320 (12%)

Query: 425  AVSPDGFVCDDFPKPQITVQPETQSA--------IKGSNLSFICSAASSSDSPMTFAWKK 476
            A SP G    +F   Q+ V P  +          ++GS +   C A      P+  +W K
Sbjct: 2195 AASPAGVADRNFTL-QVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVP-LPLV-SWMK 2251

Query: 477  DNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAK 536
            D E L    +E       QG         L+L  V     G Y CV  +  G +     +
Sbjct: 2252 DGEPLLSQSLE-------QGPS-------LQLEAVGAGDSGTYSCVAVSEAGEARR-HFQ 2296

Query: 537  LTVNMLPSFTKT--PMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHV 594
            LTV   P    +  P +L++  GA   L C A G P P I W KDG          R   
Sbjct: 2297 LTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATR 2356

Query: 595  MPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVT--KGE 652
            +          +++ D G+Y+C A++ AG+I  +  + V   P+ + P   R V      
Sbjct: 2357 V----------LRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPG 2406

Query: 653  TAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNT 712
              VL+C     P PK+ W +D   L       F    + L +     +D+G Y+C   N 
Sbjct: 2407 QLVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNA 2466

Query: 713  LGTERGNVRLSVIPTPTCDS 732
             G+     R+ +   PT  S
Sbjct: 2467 AGSTSVAFRVEIHTVPTIRS 2486



 Score = 80.9 bits (198), Expect = 6e-15
 Identities = 56/183 (30%), Positives = 79/183 (43%), Gaps = 14/183 (7%)

Query: 556 AGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYS 615
           AGA   L+C   G P PQ+ W KD     P      + V  +  V  I    + D G Y 
Sbjct: 231 AGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPH--LQVQEDGQVLRITGSHVGDEGRYQ 288

Query: 616 CTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQ-------CIAGGSPPPKL 668
           C A + AG  + +  L V   P+        +   GE AV++       C A G P P +
Sbjct: 289 CVAFSPAGQQARDFQLRVHAPPTIWG-----SNETGEVAVMEDHLVQLLCEARGVPTPNI 343

Query: 669 NWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728
            W KD + L  + +  +  G + L +  +  SDAG YTC+ SN +G      RL V   P
Sbjct: 344 TWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPP 403

Query: 729 TCD 731
           T +
Sbjct: 404 TIE 406



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 76/299 (25%), Positives = 108/299 (36%), Gaps = 21/299 (7%)

Query: 439  PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 498
            P  T  P  +S   G  L   C AA  S +P    W  ++  + +   E        GG 
Sbjct: 2938 PVFTTLPGDRSLRLGDRLWLRC-AARGSPTPR-IGWTVNDRPVTEGVSEQ------DGGS 2989

Query: 499  VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIR-AG 557
             ++   + R         G Y C   N  G + +V   + V   P          +   G
Sbjct: 2990 TLQRAAVSR------EDSGTYVCWAENRVGRTQAVSF-VHVKEAPVLQGEAFSYLVEPVG 3042

Query: 558  AMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCT 617
               +L+C   G P P I W KDG    P       H + ++    I   + +D G Y C 
Sbjct: 3043 GSIQLDCVVRGDPVPDIHWIKDG---LPLRGSHLRHQL-QNGSLTIHRTERDDAGRYQCL 3098

Query: 618  AQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPL 677
            A+N  G       L +   P F     D TV  G+   L+C A G P P + W +   PL
Sbjct: 3099 AENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPL 3158

Query: 678  VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQMT 736
              + R      +  L + + +  DAG Y C   N LG+      L V   P      MT
Sbjct: 3159 RAS-RRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEPQGSWGSMT 3216



 Score = 74.7 bits (182), Expect = 4e-13
 Identities = 67/264 (25%), Positives = 107/264 (40%), Gaps = 27/264 (10%)

Query: 496 GGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYS-VKAKLTVNMLPSFTKTPMDL-- 552
           G +V    T L +  VE    G + C  +N  G++ + V+  +     P   + P+    
Sbjct: 544 GVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYH 603

Query: 553 -------TIRAGAMARLECAAVGHPAPQIA--WQKDGG-----TDFPAARERRMHVMPED 598
                  +  A     +      HP P +   W   G      T  P A     + +P  
Sbjct: 604 WGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVA-----YSLPPP 658

Query: 599 DVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQC 658
               I  V + D G+Y+C A N AG       L VL  P+     +++ V +  +  L+C
Sbjct: 659 --LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLEC 716

Query: 659 IAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTE-- 716
           +A G PPP ++W K   P+        +   ++L I  + +SDAG Y C  SN  G+   
Sbjct: 717 LASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTEL 776

Query: 717 RGNVRLSVIPTPTCDSPQMTAPSL 740
           R  +R++V P  T   P +  P L
Sbjct: 777 RYGLRVNVPPRITL-PPSLPGPVL 799



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 58/228 (25%), Positives = 93/228 (40%), Gaps = 21/228 (9%)

Query: 498 EVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSF--TKTPMDLTIR 555
           +V E   +LR+       EG+YQCV  +  G   +   +L V+  P+   +    ++ + 
Sbjct: 266 QVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQ-ARDFQLRVHAPPTIWGSNETGEVAVM 324

Query: 556 AGAMARLECAAVGHPAPQIAWQKDGG-----TDFPAARERRMHVMPEDDVFFIVDVKIED 610
              + +L C A G P P I W KDG      T     R  R   +           +  D
Sbjct: 325 EDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGR--------AQSSD 376

Query: 611 IGVYSCTAQNSAGSISANATLTVLETPSFL----RPLLDRTVTKGETAVLQCIAGGSPPP 666
            GVY+C A N+ G+      L V   P+      RP + + V  G    L+C+A G P P
Sbjct: 377 AGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVA-GRPVALECVARGHPSP 435

Query: 667 KLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLG 714
            L+W  +  P+  +          +L +     + +G Y+C  S+  G
Sbjct: 436 TLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAG 483



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 73/296 (24%), Positives = 114/296 (38%), Gaps = 41/296 (13%)

Query: 469  PMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFG 528
            P T  W KD + +  +             +V+    +L+++  + +  G+Y CV +N  G
Sbjct: 1477 PPTIRWYKDGQPVTPSSRL----------QVLGEGRLLQIQPTQVSDSGRYLCVATNVAG 1526

Query: 529  SSYSVKAKLTVNMLPSFTKT----------PMDLTIRAGAM----------ARLECAAVG 568
                    + + + P F K             +   R G            A L C    
Sbjct: 1527 ED-DQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNA 1585

Query: 569  HPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISAN 628
             P P + W ++   D P +    + V+    V  I  V+ E+ G YSC A N  G    +
Sbjct: 1586 IPPPDLTWYRE---DQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLH 1642

Query: 629  ATLTVLETPSFL---RPLLDR-TVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHF 684
              L VL  P  L     L++  TV    T  LQC A G+P P ++W ++  P   + R  
Sbjct: 1643 YELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQ 1702

Query: 685  FAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT---CDSPQMTA 737
                 Q+L +  ++V+DA  Y C   N  G+      L V   P     D  Q+TA
Sbjct: 1703 VLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTA 1758



 Score = 71.2 bits (173), Expect = 5e-12
 Identities = 72/268 (26%), Positives = 99/268 (36%), Gaps = 31/268 (11%)

Query: 492 LRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMD 551
           L  Q G  +     L L  V  A  G Y+C  +N  GS+ S +AKL V + PS  +    
Sbjct: 45  LHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGST-SRRAKLVVYVPPSIREDGRK 103

Query: 552 LTIR--AGAMARLECAAVGHPAPQIAWQKDG------------GTDFPAARERRMHVMPE 597
             +   AG    LEC A G P P+I W KD             G D    +     ++ E
Sbjct: 104 ANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDE 163

Query: 598 DDVFFIVDVKIEDIGVYSC----TAQNSAGSISANATLTVLETPSFLRPLLDRTV----- 648
                   ++    G        +AQ  A   +  A      TP    P    +V     
Sbjct: 164 GQSLHFPRIQPGRSGRRGAQAGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGA 223

Query: 649 ------TKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHF-FAAGNQLLIIVDSDVSD 701
                   G    LQC   G P P++ WTKD  P++    H       Q+L I  S V D
Sbjct: 224 AQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGD 283

Query: 702 AGKYTCEMSNTLGTERGNVRLSVIPTPT 729
            G+Y C   +  G +  + +L V   PT
Sbjct: 284 EGRYQCVAFSPAGQQARDFQLRVHAPPT 311



 Score = 60.5 bits (145), Expect = 8e-09
 Identities = 38/112 (33%), Positives = 52/112 (46%), Gaps = 4/112 (3%)

Query: 564 CAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAG 623
           C   G P PQ+ W+K G +  P   +  + V+ E  +F +  V   D G Y C A N  G
Sbjct: 24  CGTHGTPKPQVTWRK-GPSSEPLHGQPGVAVLEEGSLF-LASVSPADSGDYECQATNEVG 81

Query: 624 SISANATLTVLETPSFLRPLLDRTVT--KGETAVLQCIAGGSPPPKLNWTKD 673
           S S  A L V   PS         V+   G++  L+C A G P P++ W KD
Sbjct: 82  STSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKD 133



 Score = 31.2 bits (69), Expect = 5.4
 Identities = 18/73 (24%), Positives = 33/73 (45%), Gaps = 1/73 (1%)

Query: 658 CIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQ-LLIIVDSDVSDAGKYTCEMSNTLGTE 716
           C   G+P P++ W K  S   +  +   A   +  L +     +D+G Y C+ +N +G+ 
Sbjct: 24  CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGST 83

Query: 717 RGNVRLSVIPTPT 729
               +L V   P+
Sbjct: 84  SRRAKLVVYVPPS 96


>gi|157694513 leucine-rich repeat-containing G protein-coupled
           receptor 4 [Homo sapiens]
          Length = 951

 Score =  120 bits (302), Expect = 5e-27
 Identities = 103/391 (26%), Positives = 178/391 (45%), Gaps = 49/391 (12%)

Query: 41  REVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISEL 100
           R V  +   L  +P    +SA    L ++ N I ++  +  K F  LE L L+ N++S +
Sbjct: 39  RRVDCSGKGLTAVPE--GLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFI 96

Query: 101 QT-AFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQL 157
              A   L +LK L L +N++ ++       L+  L  L+L+ N I+++P   F+ L QL
Sbjct: 97  HPKALSGLKELKVLTLQNNQLKTVPSEAIRGLS-ALQSLRLDANHITSVPEDSFEGLVQL 155

Query: 158 QHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTE 217
           +HL L+ N +  V       L  L++L +  N ++ + D AF  LS++ +L L +N +  
Sbjct: 156 RHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRS 215

Query: 218 ITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLL 277
           +++    GL  L+ L L+ N +    P A +    L EL    N +S + D +F G  LL
Sbjct: 216 LSQHCFDGLDNLETLDLNYNNLGEF-PQAIKALPSLKELGFHSNSISVIPDGAFDGNPLL 274

Query: 278 NTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNG----------------- 320
            T+H+ +N +S++ + AF  LS L +L ++   +     ++ G                 
Sbjct: 275 RTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSI 334

Query: 321 -------------------------AFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHL 355
                                    +F+G   L  + LQ N+I  I +  F GL +L  L
Sbjct: 335 PNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRIL 394

Query: 356 DLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 386
           DLS N I  +   AF+ +  +  L ++ + L
Sbjct: 395 DLSRNLIHEIHSRAFATLGPITNLDVSFNEL 425



 Score =  112 bits (281), Expect = 1e-24
 Identities = 75/252 (29%), Positives = 120/252 (47%), Gaps = 5/252 (1%)

Query: 137 LKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLM 195
           L ++ N I+ +P   FK  P L+ L+L  N +  +      GL  LK L +Q N +  + 
Sbjct: 62  LDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVP 121

Query: 196 DGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSE 255
             A  GLS ++ L+LD N++T + +    GL+ L+ L L  N++  +          L  
Sbjct: 122 SEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQA 181

Query: 256 LDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTI 315
           L L  N +S + D +F  LS L  LH+ NN++  ++   F GL +L+TLDL  N +    
Sbjct: 182 LTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLG--- 238

Query: 316 EDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKK 375
            +   A   L  L+ L    N I  I   AF G   L  + L DN +  +  +AF  +  
Sbjct: 239 -EFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSD 297

Query: 376 LQQLHLNTSSLL 387
           L  L +  +S++
Sbjct: 298 LHSLVIRGASMV 309



 Score =  104 bits (260), Expect = 4e-22
 Identities = 117/436 (26%), Positives = 187/436 (42%), Gaps = 83/436 (19%)

Query: 21  LSHNRLSFIKASSMSHLQSLREVKLNNNELETIPN--LGPVSANITL------------- 65
           L+ N LSFI   ++S L+ L+ + L NN+L+T+P+  +  +SA  +L             
Sbjct: 88  LAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPED 147

Query: 66  ----------LSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQT-AFPALQ-LKYLY 113
                     L L  N + E+    L    +L+ L L+ N IS +   AF  L  L  L+
Sbjct: 148 SFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLH 207

Query: 114 LNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGL 173
           L++N++ S+    FD L N L  L LN N +   P  +  LP L+ L  + N I  +   
Sbjct: 208 LHNNKIRSLSQHCFDGLDN-LETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIPDG 266

Query: 174 TFQGLGALKSLKMQRNGVTKLMDGAFWGLSNM-----------------------EILQL 210
            F G   L+++ +  N ++ + + AF  LS++                       E L L
Sbjct: 267 AFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTL 326

Query: 211 DHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSS 270
               ++ I         ML+ L LS N I  +   ++  C  L E+ L  N + ++ + +
Sbjct: 327 TGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLP--SFNGCHALEEISLQRNQIYQIKEGT 384

Query: 271 FLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEI-SWTIEDMNGAFSGLDKLR 329
           F GL  L  L +  N +  I   AF  L  +  LD+  NE+ S+  E +NG       L 
Sbjct: 385 FQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNG-------LN 437

Query: 330 RLILQGN-------------RIRSITKK------AFTGLDALEHLDLSDNAIMSLQGNAF 370
           +L L GN              +RS++        AF G D+  +L+  DN   SLQ ++ 
Sbjct: 438 QLKLVGNFKLKEALAAKDFVNLRSLSVPYAYQCCAFWGCDSYANLNTEDN---SLQDHSV 494

Query: 371 SQMKKLQQLHLNTSSL 386
           +Q K        TS+L
Sbjct: 495 AQEKGTADAANVTSTL 510



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 76/272 (27%), Positives = 121/272 (44%), Gaps = 17/272 (6%)

Query: 158 QHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTE 217
           Q L+++ N I  +    F+    L+ L++  N ++ +   A  GL  +++L L +N L  
Sbjct: 60  QALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKT 119

Query: 218 ITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLL 277
           +    + GL  LQ L L  N I  +  D++E   +L  L L  N L+ +       L  L
Sbjct: 120 VPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTL 179

Query: 278 NTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNR 337
             L +  N++S I D AF  LSSL  L L NN+I    +     F GLD L  L L  N 
Sbjct: 180 QALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQH---CFDGLDNLETLDLNYNN 236

Query: 338 IRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQ 397
           +     +A   L +L+ L    N+I  +   AF     L+ +HL  + L           
Sbjct: 237 LGEF-PQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPL----------S 285

Query: 398 WVAENNFQSFVNASCAHPQLLKGRSIFAVSPD 429
           +V  +   +F N S  H  +++G S+    P+
Sbjct: 286 FVGNS---AFHNLSDLHSLVIRGASMVQQFPN 314


>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 5065

 Score =  120 bits (301), Expect = 7e-27
 Identities = 86/291 (29%), Positives = 129/291 (44%), Gaps = 15/291 (5%)

Query: 439  PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 498
            P I   P  ++ ++ ++++  C A  S   P   +W K ++ +              G  
Sbjct: 1886 PNIEPGPVNKAVLENASVTLECLA--SGVPPPDVSWFKGHQPVSSW----------MGVT 1933

Query: 499  VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTP-MDLTIRAG 557
            V     +LR+ + + +  G Y+CV SN  GS+  ++  L VN+ P  T  P +   +   
Sbjct: 1934 VSVDGRVLRIEQAQLSDAGSYRCVASNVAGST-ELRYGLRVNVPPRITLPPSLPGPVLVN 1992

Query: 558  AMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCT 617
               RL C A G P+P + W KDG    PA     + V P   V  +   +  D G YSC 
Sbjct: 1993 TPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPG-LQVFPGGRVLTLASARASDSGRYSCV 2051

Query: 618  AQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPL 677
            A ++ G    +  L V   PS L   L+ +V   E+  L+C +   PPP L+W KD  PL
Sbjct: 2052 AVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPL 2111

Query: 678  VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728
                    +A   LL +  +DV DAG YTCE  N  G    +  L+V   P
Sbjct: 2112 EPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAP 2162



 Score =  114 bits (285), Expect = 5e-25
 Identities = 77/269 (28%), Positives = 120/269 (44%), Gaps = 18/269 (6%)

Query: 473  AWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYS 532
            +W+KD + L   E     H+ A G        +L L + + A EG Y C  SN  G+S S
Sbjct: 2195 SWRKDGQPL-PGEGAGLQHVSAVG-------RLLYLGQAQLAQEGTYTCECSNVVGNS-S 2245

Query: 533  VKAKLTVNMLPSFT---KTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARE 589
               +L V++ P      + P  +++    +A LEC A G P P + W++DG    P   E
Sbjct: 2246 QDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQ---PVGAE 2302

Query: 590  RRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSF---LRPLLDR 646
              + +  +     +   +    G YSC A+N AG       L+VL  P     L PL + 
Sbjct: 2303 LGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNI 2362

Query: 647  TVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYT 706
            T        L C A G PPP + W + + P+   E  +  AG  +L +  +   D+G Y+
Sbjct: 2363 TAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYS 2422

Query: 707  CEMSNTLGTERGNVRLSVIPTPTCDSPQM 735
            C  SN  G  R N  + V+  P+ ++  +
Sbjct: 2423 CLASNEAGEARRNFSVEVLVPPSIENEDL 2451



 Score =  106 bits (265), Expect = 1e-22
 Identities = 83/292 (28%), Positives = 133/292 (45%), Gaps = 22/292 (7%)

Query: 444  QPETQ-SAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEY 502
            +P TQ S ++    +  C+A      P T  W++D + +  AE+         G ++   
Sbjct: 2263 EPPTQVSVVQDGVATLECNATGKP--PPTVTWERDGQPV-GAEL---------GLQLQNQ 2310

Query: 503  TTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAM--- 559
               L +   + A  G+Y CV  N  G +   K +L+V + P        LT    A+   
Sbjct: 2311 GQSLHVERAQAAHTGRYSCVAENLAGRAER-KFELSVLVPPELIGDLDPLTNITAALHSP 2369

Query: 560  ARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQ 619
              L C A+G P P I W +    + P +     +++    +  +   + +D G+YSC A 
Sbjct: 2370 LTLLCEAMGIPPPAIRWFRG---EEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLAS 2426

Query: 620  NSAGSISANATLTVLETPSFLRPLLDRT--VTKGETAVLQCIAGGSPPPKLNWTKDDSPL 677
            N AG    N ++ VL  PS     L+    V  G+TA L C   G P PKL W KD  PL
Sbjct: 2427 NEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPL 2486

Query: 678  VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729
               + H  +    LL ++ +++S AG Y+C  +N +G +  + +LSV+  PT
Sbjct: 2487 ARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPT 2538



 Score =  106 bits (265), Expect = 1e-22
 Identities = 71/242 (29%), Positives = 111/242 (45%), Gaps = 9/242 (3%)

Query: 498  EVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMD-LTIRA 556
            +V+E   +L++   E A    Y CV  N  GS+  +   L V + P      ++ +T   
Sbjct: 2893 QVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFT-LRVQVPPRIAGLDLEQVTAIL 2951

Query: 557  GAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSC 616
             +   L C    HP P++ W KD       +    + ++P      +   ++ D G+Y+C
Sbjct: 2952 NSSVSLPCDVHAHPNPEVTWYKDSQA---LSLGEEVFLLPGTHTLQLGRARLSDSGMYTC 3008

Query: 617  TAQNSAGSISANATLTVLETPSFLR----PLLDRTVTKGETAVLQCIAGGSPPPKLNWTK 672
             A N+AG       L+VL  P+F +    P     V  G+ AVL C     P P + W K
Sbjct: 3009 EALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYK 3068

Query: 673  DDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDS 732
            D  PLV+ +R     G Q L I ++ VSD G Y+C++SN  G       L+V   PT ++
Sbjct: 3069 DGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFEN 3128

Query: 733  PQ 734
            P+
Sbjct: 3129 PK 3130



 Score =  106 bits (264), Expect = 1e-22
 Identities = 69/234 (29%), Positives = 107/234 (45%), Gaps = 15/234 (6%)

Query: 505  ILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNML--PSFTKTPMDLTIRA--GAMA 560
            +L++ + +    G Y C+ SN  G +   +   +V +L  PS     ++  I+   G  A
Sbjct: 2407 MLKMTQTQEQDSGLYSCLASNEAGEA---RRNFSVEVLVPPSIENEDLEEVIKVLDGQTA 2463

Query: 561  RLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQN 620
             L C   GHP P++ W KDG    P AR    H+ P+  +  ++   +   G YSC A N
Sbjct: 2464 HLMCNVTGHPQPKLTWFKDGR---PLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAAN 2520

Query: 621  SAGSISANATLTVLETPSFLRPLLDR-----TVTKGETAVLQCIAGGSPPPKLNWTKDDS 675
            + G  + +  L+VL  P+ L    D      TVT      L C A   P P + W KD +
Sbjct: 2521 AVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGA 2580

Query: 676  PLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729
            P   +       G   L I+++   DAG+YTC ++N LG    N  + V+  P+
Sbjct: 2581 PFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPS 2634



 Score =  105 bits (261), Expect = 3e-22
 Identities = 122/478 (25%), Positives = 184/478 (38%), Gaps = 75/478 (15%)

Query: 386  LLCDCQLKWLPQ--WVAENNFQSFVNASCAHPQLLKGR-----SIFAVSPDGFVCDDF-- 436
            LLCD Q    P   W  +    + +  +    ++L+ R     +  A SP G +   F  
Sbjct: 3515 LLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRV 3574

Query: 437  --PKPQITVQPETQSAIKG---SNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAH 491
                P   V P     + G     L   CS  +     +T  W +D  +L +      AH
Sbjct: 3575 RVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKIT--WHRDGIVLQED-----AH 3627

Query: 492  LRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMD 551
                  +  E    L+L+ +  A  G Y C   N  GS+ SV  ++ ++ +P+    P  
Sbjct: 3628 T-----QFPERGRFLQLQALSTADSGDYSCTARNAAGST-SVAFRVEIHTVPTIRSGPPA 3681

Query: 552  LTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDI 611
            + +     A L C A G PAP ++W+KD     P  R  R  ++PE  +  I  V  +D 
Sbjct: 3682 VNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDP--RSPRFEILPEGSLR-IQPVLAQDA 3738

Query: 612  GVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWT 671
            G Y C A NSAGS      L VLE P+      + T+T    A+L C A GSP P + W 
Sbjct: 3739 GHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWW 3798

Query: 672  KDDSPL--VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729
            KD   L   + +  +    +  L++      D+ ++ C +SN +G      +++V   PT
Sbjct: 3799 KDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPT 3858

Query: 730  CDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETN 789
                       DD    TV ++   V+ C                             T 
Sbjct: 3859 I---------ADDQTDFTVTMMAPVVLTC---------------------------HSTG 3882

Query: 790  LPADIPSYLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSGTCHIDNSS 847
            +PA   S+  +   L  R  GY  S SG+          G  LP H    TC   NS+
Sbjct: 3883 IPAPTVSWSKAGAQLGARGSGYRVSPSGALE-------IGQALPIHAGRYTCSARNSA 3933



 Score =  104 bits (260), Expect = 4e-22
 Identities = 67/209 (32%), Positives = 97/209 (46%), Gaps = 6/209 (2%)

Query: 506  LRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECA 565
            LR+        G Y C+  N  GS+   K +L V + P       DL+   G+ A L C 
Sbjct: 4002 LRIAHASPEDAGNYLCIAKNSAGSAMG-KTRLVVQVPPVIENGLPDLSTTEGSHAFLPCK 4060

Query: 566  AVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSI 625
            A G P P I W KDG     +  E +  + P  ++  + +++ +D G Y+CTA+N+ G  
Sbjct: 4061 ARGSPEPNITWDKDGQP--VSGAEGKFTIQPSGELL-VKNLEGQDAGTYTCTAENAVGRA 4117

Query: 626  SANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFF 685
                 LT+L  P F     DR++  G+   L+C A GSP P++ WT +D P  VTE    
Sbjct: 4118 RRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRP--VTEGVSE 4175

Query: 686  AAGNQLLIIVDSDVSDAGKYTCEMSNTLG 714
              G   L        D+G Y C   N +G
Sbjct: 4176 QDGGSTLQRAAVSREDSGTYVCWAENRVG 4204



 Score =  104 bits (259), Expect = 5e-22
 Identities = 87/296 (29%), Positives = 121/296 (40%), Gaps = 29/296 (9%)

Query: 451  IKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLRE 510
            + G N S  C A  +    +T+     +E LH            Q G  +     L L  
Sbjct: 1219 VAGENASLPCPARGTPKPQVTWRKGPSSEPLH-----------GQPGVAVLEEGSLFLAS 1267

Query: 511  VEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIR--AGAMARLECAAVG 568
            V  A  G Y+C  +N  GS+ S +AKL V + PS  +      +   AG    LEC A G
Sbjct: 1268 VSPADSGDYECQATNEVGST-SRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANG 1326

Query: 569  HPAPQIAWQKDG------------GTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSC 616
             P P+I W KD             G D    +     ++ E        ++  D G+YSC
Sbjct: 1327 FPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSC 1386

Query: 617  TAQNSAGSISANATLTVLETPSFLRPLLDRTV--TKGETAVLQCIAGGSPPPKLNWTKDD 674
             A+N AG+   +  L VL  PS L     + V    G    LQC   G P P++ WTKD 
Sbjct: 1387 RAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDR 1446

Query: 675  SPLVVTERHF-FAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729
             P++    H       Q+L I  S V D G+Y C   +  G +  + +L V   PT
Sbjct: 1447 QPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPT 1502



 Score =  104 bits (259), Expect = 5e-22
 Identities = 71/212 (33%), Positives = 92/212 (43%), Gaps = 5/212 (2%)

Query: 517  GKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAW 576
            G+Y C   N  G ++     LTV   P     P  +   A     L C A G P P I W
Sbjct: 3923 GRYTCSARNSAGVAHK-HVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITW 3981

Query: 577  QKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLET 636
            QK+G      A      V+P   +  I     ED G Y C A+NSAGS      L V   
Sbjct: 3982 QKEG---LNVATGVSTQVLPGGQLR-IAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVP 4037

Query: 637  PSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVD 696
            P     L D + T+G  A L C A GSP P + W KD  P+   E  F    +  L++ +
Sbjct: 4038 PVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKN 4097

Query: 697  SDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728
             +  DAG YTC   N +G  R  V L+++  P
Sbjct: 4098 LEGQDAGTYTCTAENAVGRARRRVHLTILVLP 4129



 Score =  102 bits (253), Expect = 2e-21
 Identities = 75/231 (32%), Positives = 102/231 (44%), Gaps = 12/231 (5%)

Query: 506 LRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECA 565
           LR+   +    G Y C   N  G + S + +L V   P  T+ P D+T+  G  A L C 
Sbjct: 750 LRIPAAQERDAGTYTCRAVNELGDA-SAEIQLAVGHAPQLTELPRDVTVELGRSALLACR 808

Query: 566 AVGHPAPQIAWQK-DG---GTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNS 621
           A G P P + W++ DG   G    A R  R    P+  V F   V  ED   Y C A+N 
Sbjct: 809 ATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSR-QPDSGVLFFESVAPEDQAPYVCEARNV 867

Query: 622 AGSISANATLTVL--ETPSFLRPLLDRTVTKGETAVLQCIA-GGSPPPKLNWTKDDSPLV 678
            G + A A L V     P          V +G+   L CI   G P P+ +W KD  PL 
Sbjct: 868 FGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLP 927

Query: 679 VTERHFFAAGNQLLIIVDSDVSD-AGKYTCEMSNTLGTERGNVRLSVIPTP 728
              RH   A   L +  D  + + AG+Y+C  +NT G++  +V L V   P
Sbjct: 928 PGSRHSIRADGSLHL--DRALQEHAGRYSCVATNTAGSQHRDVELVVQVPP 976



 Score = 97.4 bits (241), Expect = 6e-20
 Identities = 73/229 (31%), Positives = 105/229 (45%), Gaps = 17/229 (7%)

Query: 506  LRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECA 565
            LRL +V+    G Y+C  SN  GS+ S +  L V + P     P  L +  G    L C 
Sbjct: 1084 LRLAQVQVGDSGHYECTASNPAGSA-SHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCV 1142

Query: 566  AVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSI 625
            A G+P PQ++W KDG        + R    P+  V F   ++  D G Y C A NSAG  
Sbjct: 1143 AEGNPEPQLSWSKDG-----VVLQGR---GPQGSVHFAA-IRTSDAGRYRCEASNSAGVD 1193

Query: 626  SANATLTVLETPSF----LRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTE 681
            +    L VLE P +       LL+R    GE A L C A G+P P++ W K  S   +  
Sbjct: 1194 AWEVELRVLEPPHWGADETSGLLERVA--GENASLPCPARGTPKPQVTWRKGPSSEPLHG 1251

Query: 682  RHFFAAGNQ-LLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729
            +   A   +  L +     +D+G Y C+ +N +G+     +L V   P+
Sbjct: 1252 QPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPS 1300



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 78/293 (26%), Positives = 118/293 (40%), Gaps = 29/293 (9%)

Query: 437 PKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQG 496
           P P +TV P   + +         S     ++P    W +D           +  L A  
Sbjct: 522 PAPNVTVSPGETAVL---------SCRVLGEAPYNLTWVRD-----------WRVLPAST 561

Query: 497 GEVMEYTTI-LRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIR 555
           G V +   + L +  +     G+YQCV SN  G + +    L V   P  +         
Sbjct: 562 GRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRA-SVWLLVREAPQVSIHTSSQHFS 620

Query: 556 AGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYS 615
            G   ++ C+A G+P P I+W ++         + R+HV  +  +  I  V  ED G YS
Sbjct: 621 QGVEVKVSCSASGYPTPHISWSRESQA---LQEDSRIHVDAQGTLI-IQGVAPEDAGNYS 676

Query: 616 CTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDS 675
           C A N  G+     TL   + PS         V  GE AVL C A G PPP++ W +   
Sbjct: 677 CQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGL 736

Query: 676 PLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728
            +++       + +  L I  +   DAG YTC   N LG     ++L+V   P
Sbjct: 737 EMILAPE---GSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAP 786



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 78/290 (26%), Positives = 119/290 (41%), Gaps = 16/290 (5%)

Query: 439  PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 498
            PQ+T  P   +   G +    C A      P T  W++ +       +      R++  +
Sbjct: 786  PQLTELPRDVTVELGRSALLACRATGRP--PPTVTWRRGDGQPLGLRLGAGRGSRSRQPD 843

Query: 499  VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTV--NMLPSFTKTPMDLTIRA 556
                + +L    V    +  Y C   N FG     +A+L V  +  P    +   + +  
Sbjct: 844  ----SGVLFFESVAPEDQAPYVCEARNVFGK-VQAEARLIVTGHAPPQIASSAPTVRVLE 898

Query: 557  GAMARLECAAV-GHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYS 615
            G    L C  + G P P+  W KDG    P +R    H +  D    +     E  G YS
Sbjct: 899  GQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSR----HSIRADGSLHLDRALQEHAGRYS 954

Query: 616  CTAQNSAGSISANATLTVLETPSFLRPLLDRTVT-KGETAVLQCIAGGSPPPKLNWTKDD 674
            C A N+AGS   +  L V++ P  + P     +T +G  A L C+A G P P + WTK+ 
Sbjct: 955  CVATNTAGSQHRDVEL-VVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKET 1013

Query: 675  SPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSV 724
            + L     H+  +    L+I      DAG Y C  +NT+G     +RLSV
Sbjct: 1014 NALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSV 1063



 Score = 93.2 bits (230), Expect = 1e-18
 Identities = 83/294 (28%), Positives = 125/294 (42%), Gaps = 25/294 (8%)

Query: 446  ETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTI 505
            ET S + GS L   C   S   +P T  W KD   +  + +       ++GG        
Sbjct: 3132 ETVSQVAGSPLVLTCDV-SGVPAP-TVTWLKDRMPVESSAVHGVV---SRGGR------- 3179

Query: 506  LRLREVEFASEGKYQCVISNHFGSSYS--VKAKLTVNMLPSFTKTPMDLTIRAGAMARLE 563
            L+L  ++ A  G Y CV  N    +    V A L    + S +    +  +  G   RL+
Sbjct: 3180 LQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRS-SGVAREHHVLEGQEVRLD 3238

Query: 564  CAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIV--DVKIEDIGVYSCTAQNS 621
            C A G P P +AW KDG    P  ++   H+    D   +V   ++  D G Y+C A N 
Sbjct: 3239 CEADGQPPPDVAWLKDGS---PLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNP 3295

Query: 622  AGSISANATLTVLETPSFLRPLLDRTVT----KGETAVLQCIAGGSPPPKLNWTKDDSPL 677
            AG  +   T+ VL  P+ ++   D + T     GE   + C   GSPP  ++W KD  PL
Sbjct: 3296 AGEDARLHTVNVLVPPT-IKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPL 3354

Query: 678  VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCD 731
             +++R         L I    ++DAG +TC  ++  G    N  L V   P  +
Sbjct: 3355 PLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVLE 3408



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 69/227 (30%), Positives = 101/227 (44%), Gaps = 7/227 (3%)

Query: 506  LRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECA 565
            L++ +V+   EG Y C  +N  G S    A L V + P+    P++  +   A   LEC 
Sbjct: 1850 LQIEKVDLRDEGIYTCAATNLAGESKREVA-LKVLVPPNIEPGPVNKAVLENASVTLECL 1908

Query: 566  AVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSI 625
            A G P P ++W K      P +    + V  +  V  I   ++ D G Y C A N AGS 
Sbjct: 1909 ASGVPPPDVSWFKGHQ---PVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGST 1965

Query: 626  SANATLTVLETPSF-LRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPL--VVTER 682
                 L V   P   L P L   V       L C A G+P P L W KD +P+    T  
Sbjct: 1966 ELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPG 2025

Query: 683  HFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729
                 G ++L +  +  SD+G+Y+C   + +G +R +V L V   P+
Sbjct: 2026 LQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPS 2072



 Score = 90.9 bits (224), Expect = 6e-18
 Identities = 78/272 (28%), Positives = 120/272 (44%), Gaps = 18/272 (6%)

Query: 463  ASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCV 522
            AS S  P+   WK   +L  D  ++       QG   +  +  L L         +++CV
Sbjct: 3787 ASGSPKPLVVWWKDGQKL--DFRLQ-------QGAYRLLPSNALLLTAPGPQDSAQFECV 3837

Query: 523  ISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGT 582
            +SN  G ++ +  ++TV++ P+      D T+   A   L C + G PAP ++W K G  
Sbjct: 3838 VSNEVGEAHRLY-QVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQ 3896

Query: 583  DFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRP 642
                AR     V P   +     + I   G Y+C+A+NSAG    +  LTV  +P  ++P
Sbjct: 3897 --LGARGSGYRVSPSGALEIGQALPIH-AGRYTCSARNSAGVAHKHVFLTVQASP-VVKP 3952

Query: 643  L--LDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVS 700
            L  + R V + E  +L C A G P P + W K+   +          G QL I   +   
Sbjct: 3953 LPSVVRAVAE-EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRI-AHASPE 4010

Query: 701  DAGKYTCEMSNTLGTERGNVRLSVIPTPTCDS 732
            DAG Y C   N+ G+  G  RL V   P  ++
Sbjct: 4011 DAGNYLCIAKNSAGSAMGKTRLVVQVPPVIEN 4042



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 76/294 (25%), Positives = 112/294 (38%), Gaps = 18/294 (6%)

Query: 439  PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 498
            P I  +    S +   +++  C   S +  P   +W KD   L   E     HL A    
Sbjct: 2071 PSILGEELNVSVVANESVALECQ--SHAMPPPVLSWWKDGRPL---EPRPGVHLSAD--- 2122

Query: 499  VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFT-KTPMDLTIRAG 557
                  +L++   +    G Y C   N  G S      L V + P F  +    LT+R G
Sbjct: 2123 ----KALLQVDRADVWDAGHYTCEALNQAGHSEK-HYNLNVWVAPVFPLRESHTLTVREG 2177

Query: 558  AMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCT 617
                L C   G P P+I+W+KD G   P       HV     + ++   ++   G Y+C 
Sbjct: 2178 HPTSLSCECRGVPFPKISWRKD-GQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCE 2236

Query: 618  AQNSAGSISANATLTVLETPSFLRPLLDRT---VTKGETAVLQCIAGGSPPPKLNWTKDD 674
              N  G+ S +  L V   P    P    T   V +   A L+C A G PPP + W +D 
Sbjct: 2237 CSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDG 2296

Query: 675  SPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728
             P+            Q L +  +  +  G+Y+C   N  G       LSV+  P
Sbjct: 2297 QPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPP 2350



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 74/300 (24%), Positives = 120/300 (40%), Gaps = 43/300 (14%)

Query: 456  LSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFAS 515
            +S IC A +     +T  W KD      A  E   +++   G     T  L++   +   
Sbjct: 2559 ISLICEALAFPSPNIT--WMKDG-----APFEASRNIQLLPG-----THGLQILNAQKED 2606

Query: 516  EGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTP-------MDLTIRAGAMARLECAAVG 568
             G+Y CV++N  G +      + V + PS +K          ++  +  +   LEC +  
Sbjct: 2607 AGQYTCVVTNELGEAVK-NYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWA 2665

Query: 569  HPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISAN 628
             P P I W KDG    P     R+ V+ E  +  I   ++ D G Y C A N AG    +
Sbjct: 2666 VPPPTIRWYKDGQ---PVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQD 2722

Query: 629  ATLTVLETPSFLR--------PLLDRT------------VTKGETAVLQCIAGGSPPPKL 668
              + +   P F +         +L R             + +   A L C     PPP L
Sbjct: 2723 FNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDL 2782

Query: 669  NWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728
             W ++D PL   +      G ++L I      +AG+Y+C+ SN +G +  +  L V+  P
Sbjct: 2783 TWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPP 2842



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 79/296 (26%), Positives = 116/296 (39%), Gaps = 34/296 (11%)

Query: 439 PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 498
           PQ+++   +Q   +G  +   CSA S   +P   +W ++++ L +   ++  H+ AQG  
Sbjct: 608 PQVSIHTSSQHFSQGVEVKVSCSA-SGYPTPH-ISWSRESQALQE---DSRIHVDAQG-- 660

Query: 499 VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGA 558
                  L ++ V     G Y C  +N  G+       L     PS +     + +  G 
Sbjct: 661 ------TLIIQGVAPEDAGNYSCQATNEVGTDQET-VTLYYTDPPSVSAVNAVVLVAVGE 713

Query: 559 MARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTA 618
            A L C A G P P++ W + GG +   A E             I   +  D G Y+C A
Sbjct: 714 EAVLVCEASGVPPPRVIWYR-GGLEMILAPEGS-----SSGKLRIPAAQERDAGTYTCRA 767

Query: 619 QNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTK-DDSPL 677
            N  G  SA   L V   P       D TV  G +A+L C A G PPP + W + D  PL
Sbjct: 768 VNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPL 827

Query: 678 VVTERHFFAAG---------NQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSV 724
            +       AG         + +L        D   Y CE  N  G  +   RL V
Sbjct: 828 GLR----LGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV 879



 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 62/223 (27%), Positives = 95/223 (42%), Gaps = 2/223 (0%)

Query: 506  LRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECA 565
            LR++ V     G Y C+ SN  GS    +  L V   P+   +P +LT+ A   A L C 
Sbjct: 3728 LRIQPVLAQDAGHYLCLASNSAGSDRQGR-DLRVLEPPAIAPSPSNLTLTAHTPALLPCE 3786

Query: 566  AVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSI 625
            A G P P + W KDG       ++    ++P + +        +D   + C   N  G  
Sbjct: 3787 ASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGP-QDSAQFECVVSNEVGEA 3845

Query: 626  SANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFF 685
                 +TV   P+      D TVT     VL C + G P P ++W+K  + L      + 
Sbjct: 3846 HRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYR 3905

Query: 686  AAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728
             + +  L I  +    AG+YTC   N+ G    +V L+V  +P
Sbjct: 3906 VSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASP 3948



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 67/245 (27%), Positives = 99/245 (40%), Gaps = 17/245 (6%)

Query: 496  GGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSF--TKTPMDLT 553
            G  +++    L    ++    G Y C   N  G++      L V   PS        ++ 
Sbjct: 1361 GHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQR-DFHLLVLTPPSVLGAGAAQEVL 1419

Query: 554  IRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGV 613
              AGA   L+C   G P PQ+ W KD     P      + V  +  V  I    + D G 
Sbjct: 1420 GLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPH--LQVQEDGQVLRITGSHVGDEGR 1477

Query: 614  YSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQ-------CIAGGSPPP 666
            Y C A + AG  + +  L V   P+        +   GE AV++       C A G P P
Sbjct: 1478 YQCVAFSPAGQQARDFQLRVHAPPTIWG-----SNETGEVAVMEDHLVQLLCEARGVPTP 1532

Query: 667  KLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIP 726
             + W KD + L  + +  +  G + L +  +  SDAG YTC+ SN +G      RL V  
Sbjct: 1533 NITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYV 1592

Query: 727  TPTCD 731
             PT +
Sbjct: 1593 PPTIE 1597



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 82/311 (26%), Positives = 121/311 (38%), Gaps = 26/311 (8%)

Query: 425  AVSPDGFVCDDFP-----KPQITVQPET-QSAIKGSNLSFICSAASSSDSPMTFAWKKDN 478
            A SP G    DF       P I    ET + A+   +L  +   A    +P    W KD 
Sbjct: 1482 AFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTP-NITWFKDG 1540

Query: 479  ELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLT 538
             LL  +    Y     +GG        L+L   + +  G Y C  SN  G++     +L 
Sbjct: 1541 ALLPTSTKVVYT----RGGRQ------LQLGRAQSSDAGVYTCKASNAVGAAEKA-TRLD 1589

Query: 539  VNMLPSFTKT---PMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVM 595
            V + P+       P  +   AG    LEC A GHP+P ++W  +G    P A      + 
Sbjct: 1590 VYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEG---LPVAESNESRLE 1646

Query: 596  PEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFL--RPLLDRTVTKGET 653
             +  V  +        G+YSC A + AG      ++ V   P  L    L   T   G+ 
Sbjct: 1647 TDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQP 1706

Query: 654  AVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTL 713
              L C A GSP P + W ++  P         A+    L I   ++  +G + C+ +N  
Sbjct: 1707 LELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEA 1766

Query: 714  GTERGNVRLSV 724
            GT    V +SV
Sbjct: 1767 GTAGAEVEVSV 1777



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 83/320 (25%), Positives = 124/320 (38%), Gaps = 40/320 (12%)

Query: 425  AVSPDGFVCDDFPKPQITVQPETQSA--------IKGSNLSFICSAASSSDSPMTFAWKK 476
            A SP G    +F   Q+ V P  +          ++GS +   C A      P+  +W K
Sbjct: 3386 AASPAGVADRNFTL-QVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVP-LPLV-SWMK 3442

Query: 477  DNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAK 536
            D E L    +E       QG         L+L  V     G Y CV  +  G +     +
Sbjct: 3443 DGEPLLSQSLE-------QGPS-------LQLEAVGAGDSGTYSCVAVSEAGEARR-HFQ 3487

Query: 537  LTVNMLPSFTKT--PMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHV 594
            LTV   P    +  P +L++  GA   L C A G P P I W KDG          R   
Sbjct: 3488 LTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATR 3547

Query: 595  MPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVT--KGE 652
            +          +++ D G+Y+C A++ AG+I  +  + V   P+ + P   R V      
Sbjct: 3548 V----------LRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPG 3597

Query: 653  TAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNT 712
              VL+C     P PK+ W +D   L       F    + L +     +D+G Y+C   N 
Sbjct: 3598 QLVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNA 3657

Query: 713  LGTERGNVRLSVIPTPTCDS 732
             G+     R+ +   PT  S
Sbjct: 3658 AGSTSVAFRVEIHTVPTIRS 3677



 Score = 80.9 bits (198), Expect = 6e-15
 Identities = 68/248 (27%), Positives = 105/248 (42%), Gaps = 13/248 (5%)

Query: 483 DAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNML 542
           +A +    H +  G    E   ILR  + E   EG Y+C   +  G+  + KA++ V   
Sbjct: 464 EARLGEERHFQESGNSSWE---ILRASKAE---EGTYECTAVSRAGTGRA-KAQIVVTDP 516

Query: 543 PSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFF 602
           P       ++T+  G  A L C  +G     + W +D     PA+  R   +   D    
Sbjct: 517 PPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRV-LPASTGRVAQLA--DLSLE 573

Query: 603 IVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGG 662
           I  +   D G Y C A N+ G   A+  L V E P        +  ++G    + C A G
Sbjct: 574 ISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASG 633

Query: 663 SPPPKLNWTKDDSPLVVTER-HFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVR 721
            P P ++W+++   L    R H  A G   LII      DAG Y+C+ +N +GT++  V 
Sbjct: 634 YPTPHISWSRESQALQEDSRIHVDAQGT--LIIQGVAPEDAGNYSCQATNEVGTDQETVT 691

Query: 722 LSVIPTPT 729
           L     P+
Sbjct: 692 LYYTDPPS 699



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 76/299 (25%), Positives = 108/299 (36%), Gaps = 21/299 (7%)

Query: 439  PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 498
            P  T  P  +S   G  L   C AA  S +P    W  ++  + +   E        GG 
Sbjct: 4129 PVFTTLPGDRSLRLGDRLWLRC-AARGSPTPR-IGWTVNDRPVTEGVSEQ------DGGS 4180

Query: 499  VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIR-AG 557
             ++   + R         G Y C   N  G + +V   + V   P          +   G
Sbjct: 4181 TLQRAAVSR------EDSGTYVCWAENRVGRTQAVSF-VHVKEAPVLQGEAFSYLVEPVG 4233

Query: 558  AMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCT 617
               +L+C   G P P I W KDG    P       H + ++    I   + +D G Y C 
Sbjct: 4234 GSIQLDCVVRGDPVPDIHWIKDG---LPLRGSHLRHQL-QNGSLTIHRTERDDAGRYQCL 4289

Query: 618  AQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPL 677
            A+N  G       L +   P F     D TV  G+   L+C A G P P + W +   PL
Sbjct: 4290 AENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPL 4349

Query: 678  VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQMT 736
              + R      +  L + + +  DAG Y C   N LG+      L V   P      MT
Sbjct: 4350 RAS-RRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEPQGSWGSMT 4407



 Score = 74.7 bits (182), Expect = 4e-13
 Identities = 67/264 (25%), Positives = 107/264 (40%), Gaps = 27/264 (10%)

Query: 496  GGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYS-VKAKLTVNMLPSFTKTPMDL-- 552
            G +V    T L +  VE    G + C  +N  G++ + V+  +     P   + P+    
Sbjct: 1735 GVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYH 1794

Query: 553  -------TIRAGAMARLECAAVGHPAPQIA--WQKDGG-----TDFPAARERRMHVMPED 598
                   +  A     +      HP P +   W   G      T  P A     + +P  
Sbjct: 1795 WGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVA-----YSLPPP 1849

Query: 599  DVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQC 658
                I  V + D G+Y+C A N AG       L VL  P+     +++ V +  +  L+C
Sbjct: 1850 --LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLEC 1907

Query: 659  IAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTE-- 716
            +A G PPP ++W K   P+        +   ++L I  + +SDAG Y C  SN  G+   
Sbjct: 1908 LASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTEL 1967

Query: 717  RGNVRLSVIPTPTCDSPQMTAPSL 740
            R  +R++V P  T   P +  P L
Sbjct: 1968 RYGLRVNVPPRITL-PPSLPGPVL 1990



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 58/228 (25%), Positives = 93/228 (40%), Gaps = 21/228 (9%)

Query: 498  EVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSF--TKTPMDLTIR 555
            +V E   +LR+       EG+YQCV  +  G   +   +L V+  P+   +    ++ + 
Sbjct: 1457 QVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQ-ARDFQLRVHAPPTIWGSNETGEVAVM 1515

Query: 556  AGAMARLECAAVGHPAPQIAWQKDGG-----TDFPAARERRMHVMPEDDVFFIVDVKIED 610
               + +L C A G P P I W KDG      T     R  R   +           +  D
Sbjct: 1516 EDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGR--------AQSSD 1567

Query: 611  IGVYSCTAQNSAGSISANATLTVLETPSFL----RPLLDRTVTKGETAVLQCIAGGSPPP 666
             GVY+C A N+ G+      L V   P+      RP + + V  G    L+C+A G P P
Sbjct: 1568 AGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVA-GRPVALECVARGHPSP 1626

Query: 667  KLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLG 714
             L+W  +  P+  +          +L +     + +G Y+C  S+  G
Sbjct: 1627 TLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAG 1674



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 73/296 (24%), Positives = 114/296 (38%), Gaps = 41/296 (13%)

Query: 469  PMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFG 528
            P T  W KD + +  +             +V+    +L+++  + +  G+Y CV +N  G
Sbjct: 2668 PPTIRWYKDGQPVTPSSRL----------QVLGEGRLLQIQPTQVSDSGRYLCVATNVAG 2717

Query: 529  SSYSVKAKLTVNMLPSFTKT----------PMDLTIRAGAM----------ARLECAAVG 568
                    + + + P F K             +   R G            A L C    
Sbjct: 2718 ED-DQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNA 2776

Query: 569  HPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISAN 628
             P P + W ++   D P +    + V+    V  I  V+ E+ G YSC A N  G    +
Sbjct: 2777 IPPPDLTWYRE---DQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLH 2833

Query: 629  ATLTVLETPSFL---RPLLDR-TVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHF 684
              L VL  P  L     L++  TV    T  LQC A G+P P ++W ++  P   + R  
Sbjct: 2834 YELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQ 2893

Query: 685  FAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT---CDSPQMTA 737
                 Q+L +  ++V+DA  Y C   N  G+      L V   P     D  Q+TA
Sbjct: 2894 VLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTA 2949


>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3783

 Score =  120 bits (301), Expect = 7e-27
 Identities = 86/291 (29%), Positives = 129/291 (44%), Gaps = 15/291 (5%)

Query: 439 PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 498
           P I   P  ++ ++ ++++  C A  S   P   +W K ++ +              G  
Sbjct: 604 PNIEPGPVNKAVLENASVTLECLA--SGVPPPDVSWFKGHQPVSSW----------MGVT 651

Query: 499 VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTP-MDLTIRAG 557
           V     +LR+ + + +  G Y+CV SN  GS+  ++  L VN+ P  T  P +   +   
Sbjct: 652 VSVDGRVLRIEQAQLSDAGSYRCVASNVAGST-ELRYGLRVNVPPRITLPPSLPGPVLVN 710

Query: 558 AMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCT 617
              RL C A G P+P + W KDG    PA     + V P   V  +   +  D G YSC 
Sbjct: 711 TPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPG-LQVFPGGRVLTLASARASDSGRYSCV 769

Query: 618 AQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPL 677
           A ++ G    +  L V   PS L   L+ +V   E+  L+C +   PPP L+W KD  PL
Sbjct: 770 AVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPL 829

Query: 678 VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728
                   +A   LL +  +DV DAG YTCE  N  G    +  L+V   P
Sbjct: 830 EPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAP 880



 Score =  114 bits (285), Expect = 5e-25
 Identities = 77/269 (28%), Positives = 120/269 (44%), Gaps = 18/269 (6%)

Query: 473  AWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYS 532
            +W+KD + L   E     H+ A G        +L L + + A EG Y C  SN  G+S S
Sbjct: 913  SWRKDGQPL-PGEGAGLQHVSAVG-------RLLYLGQAQLAQEGTYTCECSNVVGNS-S 963

Query: 533  VKAKLTVNMLPSFT---KTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARE 589
               +L V++ P      + P  +++    +A LEC A G P P + W++DG    P   E
Sbjct: 964  QDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQ---PVGAE 1020

Query: 590  RRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSF---LRPLLDR 646
              + +  +     +   +    G YSC A+N AG       L+VL  P     L PL + 
Sbjct: 1021 LGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNI 1080

Query: 647  TVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYT 706
            T        L C A G PPP + W + + P+   E  +  AG  +L +  +   D+G Y+
Sbjct: 1081 TAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYS 1140

Query: 707  CEMSNTLGTERGNVRLSVIPTPTCDSPQM 735
            C  SN  G  R N  + V+  P+ ++  +
Sbjct: 1141 CLASNEAGEARRNFSVEVLVPPSIENEDL 1169



 Score =  107 bits (268), Expect = 5e-23
 Identities = 75/255 (29%), Positives = 113/255 (44%), Gaps = 24/255 (9%)

Query: 505  ILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNML--PSFTKTPMDLTIRA--GAMA 560
            +L++ + +    G Y C+ SN  G +   +   +V +L  PS     ++  I+   G  A
Sbjct: 1125 MLKMTQTQEQDSGLYSCLASNEAGEA---RRNFSVEVLVPPSIENEDLEEVIKVLDGQTA 1181

Query: 561  RLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQN 620
             L C   GHP P++ W KDG    P AR    H+ P+  +  ++   +   G YSC A N
Sbjct: 1182 HLMCNVTGHPQPKLTWFKDGR---PLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAAN 1238

Query: 621  SAGSISANATLTVLETPSFLRPLLDR-----TVTKGETAVLQCIAGGSPPPKLNWTKDDS 675
            + G  + +  L+VL  P+ L    D      TVT      L C A   P P + W KD +
Sbjct: 1239 AVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGA 1298

Query: 676  PLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQM 735
            P   +       G   L I+++   DAG+YTC ++N LG    N  + V+  P+      
Sbjct: 1299 PFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISK--- 1355

Query: 736  TAPSLDDDGWATVGV 750
                  DD  A VGV
Sbjct: 1356 ------DDPLAEVGV 1364



 Score =  106 bits (265), Expect = 1e-22
 Identities = 83/292 (28%), Positives = 133/292 (45%), Gaps = 22/292 (7%)

Query: 444  QPETQ-SAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEY 502
            +P TQ S ++    +  C+A      P T  W++D + +  AE+         G ++   
Sbjct: 981  EPPTQVSVVQDGVATLECNATGKP--PPTVTWERDGQPV-GAEL---------GLQLQNQ 1028

Query: 503  TTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAM--- 559
               L +   + A  G+Y CV  N  G +   K +L+V + P        LT    A+   
Sbjct: 1029 GQSLHVERAQAAHTGRYSCVAENLAGRAER-KFELSVLVPPELIGDLDPLTNITAALHSP 1087

Query: 560  ARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQ 619
              L C A+G P P I W +    + P +     +++    +  +   + +D G+YSC A 
Sbjct: 1088 LTLLCEAMGIPPPAIRWFRG---EEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLAS 1144

Query: 620  NSAGSISANATLTVLETPSFLRPLLDRT--VTKGETAVLQCIAGGSPPPKLNWTKDDSPL 677
            N AG    N ++ VL  PS     L+    V  G+TA L C   G P PKL W KD  PL
Sbjct: 1145 NEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPL 1204

Query: 678  VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729
               + H  +    LL ++ +++S AG Y+C  +N +G +  + +LSV+  PT
Sbjct: 1205 ARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPT 1256



 Score =  106 bits (265), Expect = 1e-22
 Identities = 71/242 (29%), Positives = 111/242 (45%), Gaps = 9/242 (3%)

Query: 498  EVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMD-LTIRA 556
            +V+E   +L++   E A    Y CV  N  GS+  +   L V + P      ++ +T   
Sbjct: 1611 QVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFT-LRVQVPPRIAGLDLEQVTAIL 1669

Query: 557  GAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSC 616
             +   L C    HP P++ W KD       +    + ++P      +   ++ D G+Y+C
Sbjct: 1670 NSSVSLPCDVHAHPNPEVTWYKDSQA---LSLGEEVFLLPGTHTLQLGRARLSDSGMYTC 1726

Query: 617  TAQNSAGSISANATLTVLETPSFLR----PLLDRTVTKGETAVLQCIAGGSPPPKLNWTK 672
             A N+AG       L+VL  P+F +    P     V  G+ AVL C     P P + W K
Sbjct: 1727 EALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYK 1786

Query: 673  DDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDS 732
            D  PLV+ +R     G Q L I ++ VSD G Y+C++SN  G       L+V   PT ++
Sbjct: 1787 DGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFEN 1846

Query: 733  PQ 734
            P+
Sbjct: 1847 PK 1848



 Score =  105 bits (261), Expect = 3e-22
 Identities = 122/478 (25%), Positives = 184/478 (38%), Gaps = 75/478 (15%)

Query: 386  LLCDCQLKWLPQ--WVAENNFQSFVNASCAHPQLLKGR-----SIFAVSPDGFVCDDF-- 436
            LLCD Q    P   W  +    + +  +    ++L+ R     +  A SP G +   F  
Sbjct: 2233 LLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRV 2292

Query: 437  --PKPQITVQPETQSAIKG---SNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAH 491
                P   V P     + G     L   CS  +     +T  W +D  +L +      AH
Sbjct: 2293 RVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKIT--WHRDGIVLQED-----AH 2345

Query: 492  LRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMD 551
                  +  E    L+L+ +  A  G Y C   N  GS+ SV  ++ ++ +P+    P  
Sbjct: 2346 T-----QFPERGRFLQLQALSTADSGDYSCTARNAAGST-SVAFRVEIHTVPTIRSGPPA 2399

Query: 552  LTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDI 611
            + +     A L C A G PAP ++W+KD     P  R  R  ++PE  +  I  V  +D 
Sbjct: 2400 VNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDP--RSPRFEILPEGSLR-IQPVLAQDA 2456

Query: 612  GVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWT 671
            G Y C A NSAGS      L VLE P+      + T+T    A+L C A GSP P + W 
Sbjct: 2457 GHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWW 2516

Query: 672  KDDSPL--VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729
            KD   L   + +  +    +  L++      D+ ++ C +SN +G      +++V   PT
Sbjct: 2517 KDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPT 2576

Query: 730  CDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETN 789
                       DD    TV ++   V+ C                             T 
Sbjct: 2577 I---------ADDQTDFTVTMMAPVVLTC---------------------------HSTG 2600

Query: 790  LPADIPSYLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSGTCHIDNSS 847
            +PA   S+  +   L  R  GY  S SG+          G  LP H    TC   NS+
Sbjct: 2601 IPAPTVSWSKAGAQLGARGSGYRVSPSGALE-------IGQALPIHAGRYTCSARNSA 2651



 Score =  104 bits (260), Expect = 4e-22
 Identities = 67/209 (32%), Positives = 97/209 (46%), Gaps = 6/209 (2%)

Query: 506  LRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECA 565
            LR+        G Y C+  N  GS+   K +L V + P       DL+   G+ A L C 
Sbjct: 2720 LRIAHASPEDAGNYLCIAKNSAGSAMG-KTRLVVQVPPVIENGLPDLSTTEGSHAFLPCK 2778

Query: 566  AVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSI 625
            A G P P I W KDG     +  E +  + P  ++  + +++ +D G Y+CTA+N+ G  
Sbjct: 2779 ARGSPEPNITWDKDGQP--VSGAEGKFTIQPSGELL-VKNLEGQDAGTYTCTAENAVGRA 2835

Query: 626  SANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFF 685
                 LT+L  P F     DR++  G+   L+C A GSP P++ WT +D P  VTE    
Sbjct: 2836 RRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRP--VTEGVSE 2893

Query: 686  AAGNQLLIIVDSDVSDAGKYTCEMSNTLG 714
              G   L        D+G Y C   N +G
Sbjct: 2894 QDGGSTLQRAAVSREDSGTYVCWAENRVG 2922



 Score =  104 bits (259), Expect = 5e-22
 Identities = 71/212 (33%), Positives = 92/212 (43%), Gaps = 5/212 (2%)

Query: 517  GKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAW 576
            G+Y C   N  G ++     LTV   P     P  +   A     L C A G P P I W
Sbjct: 2641 GRYTCSARNSAGVAHK-HVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITW 2699

Query: 577  QKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLET 636
            QK+G      A      V+P   +  I     ED G Y C A+NSAGS      L V   
Sbjct: 2700 QKEG---LNVATGVSTQVLPGGQLR-IAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVP 2755

Query: 637  PSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVD 696
            P     L D + T+G  A L C A GSP P + W KD  P+   E  F    +  L++ +
Sbjct: 2756 PVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKN 2815

Query: 697  SDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728
             +  DAG YTC   N +G  R  V L+++  P
Sbjct: 2816 LEGQDAGTYTCTAENAVGRARRRVHLTILVLP 2847



 Score = 93.2 bits (230), Expect = 1e-18
 Identities = 83/294 (28%), Positives = 125/294 (42%), Gaps = 25/294 (8%)

Query: 446  ETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTI 505
            ET S + GS L   C   S   +P T  W KD   +  + +       ++GG        
Sbjct: 1850 ETVSQVAGSPLVLTCDV-SGVPAP-TVTWLKDRMPVESSAVHGVV---SRGGR------- 1897

Query: 506  LRLREVEFASEGKYQCVISNHFGSSYS--VKAKLTVNMLPSFTKTPMDLTIRAGAMARLE 563
            L+L  ++ A  G Y CV  N    +    V A L    + S +    +  +  G   RL+
Sbjct: 1898 LQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRS-SGVAREHHVLEGQEVRLD 1956

Query: 564  CAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIV--DVKIEDIGVYSCTAQNS 621
            C A G P P +AW KDG    P  ++   H+    D   +V   ++  D G Y+C A N 
Sbjct: 1957 CEADGQPPPDVAWLKDGS---PLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNP 2013

Query: 622  AGSISANATLTVLETPSFLRPLLDRTVT----KGETAVLQCIAGGSPPPKLNWTKDDSPL 677
            AG  +   T+ VL  P+ ++   D + T     GE   + C   GSPP  ++W KD  PL
Sbjct: 2014 AGEDARLHTVNVLVPPT-IKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPL 2072

Query: 678  VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCD 731
             +++R         L I    ++DAG +TC  ++  G    N  L V   P  +
Sbjct: 2073 PLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVLE 2126



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 69/227 (30%), Positives = 101/227 (44%), Gaps = 7/227 (3%)

Query: 506 LRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECA 565
           L++ +V+   EG Y C  +N  G S    A L V + P+    P++  +   A   LEC 
Sbjct: 568 LQIEKVDLRDEGIYTCAATNLAGESKREVA-LKVLVPPNIEPGPVNKAVLENASVTLECL 626

Query: 566 AVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSI 625
           A G P P ++W K      P +    + V  +  V  I   ++ D G Y C A N AGS 
Sbjct: 627 ASGVPPPDVSWFKGHQ---PVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGST 683

Query: 626 SANATLTVLETPSF-LRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPL--VVTER 682
                L V   P   L P L   V       L C A G+P P L W KD +P+    T  
Sbjct: 684 ELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPG 743

Query: 683 HFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPT 729
                G ++L +  +  SD+G+Y+C   + +G +R +V L V   P+
Sbjct: 744 LQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPS 790



 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 77/294 (26%), Positives = 113/294 (38%), Gaps = 18/294 (6%)

Query: 439  PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 498
            P I  +    S +   +++  C   S +  P   +W KD   L   E     HL A    
Sbjct: 789  PSILGEELNVSVVANESVALECQ--SHAMPPPVLSWWKDGRPL---EPRPGVHLSAD--- 840

Query: 499  VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFT-KTPMDLTIRAG 557
                  +L++   +    G Y C   N  G S      L V + P F  +    LT+R G
Sbjct: 841  ----KALLQVDRADVWDAGHYTCEALNQAGHSEK-HYNLNVWVAPVFPLRESHTLTVREG 895

Query: 558  AMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCT 617
               RL C   G P P+I+W+KD G   P       HV     + ++   ++   G Y+C 
Sbjct: 896  HPTRLSCECRGVPFPKISWRKD-GQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCE 954

Query: 618  AQNSAGSISANATLTVLETPSFLRPLLDRT---VTKGETAVLQCIAGGSPPPKLNWTKDD 674
              N  G+ S +  L V   P    P    T   V +   A L+C A G PPP + W +D 
Sbjct: 955  CSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDG 1014

Query: 675  SPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728
             P+            Q L +  +  +  G+Y+C   N  G       LSV+  P
Sbjct: 1015 QPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPP 1068



 Score = 90.9 bits (224), Expect = 6e-18
 Identities = 78/272 (28%), Positives = 120/272 (44%), Gaps = 18/272 (6%)

Query: 463  ASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCV 522
            AS S  P+   WK   +L  D  ++       QG   +  +  L L         +++CV
Sbjct: 2505 ASGSPKPLVVWWKDGQKL--DFRLQ-------QGAYRLLPSNALLLTAPGPQDSAQFECV 2555

Query: 523  ISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGT 582
            +SN  G ++ +  ++TV++ P+      D T+   A   L C + G PAP ++W K G  
Sbjct: 2556 VSNEVGEAHRLY-QVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQ 2614

Query: 583  DFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRP 642
                AR     V P   +     + I   G Y+C+A+NSAG    +  LTV  +P  ++P
Sbjct: 2615 --LGARGSGYRVSPSGALEIGQALPIH-AGRYTCSARNSAGVAHKHVFLTVQASP-VVKP 2670

Query: 643  L--LDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVS 700
            L  + R V + E  +L C A G P P + W K+   +          G QL I   +   
Sbjct: 2671 LPSVVRAVAE-EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRI-AHASPE 2728

Query: 701  DAGKYTCEMSNTLGTERGNVRLSVIPTPTCDS 732
            DAG Y C   N+ G+  G  RL V   P  ++
Sbjct: 2729 DAGNYLCIAKNSAGSAMGKTRLVVQVPPVIEN 2760



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 74/300 (24%), Positives = 120/300 (40%), Gaps = 43/300 (14%)

Query: 456  LSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFAS 515
            +S IC A +     +T  W KD      A  E   +++   G     T  L++   +   
Sbjct: 1277 ISLICEALAFPSPNIT--WMKDG-----APFEASRNIQLLPG-----THGLQILNAQKED 1324

Query: 516  EGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTP-------MDLTIRAGAMARLECAAVG 568
             G+Y CV++N  G +      + V + PS +K          ++  +  +   LEC +  
Sbjct: 1325 AGQYTCVVTNELGEAVK-NYHVEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESWA 1383

Query: 569  HPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISAN 628
             P P I W KDG    P     R+ V+ E  +  I   ++ D G Y C A N AG    +
Sbjct: 1384 VPPPTIRWYKDGQ---PVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQD 1440

Query: 629  ATLTVLETPSFLR--------PLLDRT------------VTKGETAVLQCIAGGSPPPKL 668
              + +   P F +         +L R             + +   A L C     PPP L
Sbjct: 1441 FNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDL 1500

Query: 669  NWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728
             W ++D PL   +      G ++L I      +AG+Y+C+ SN +G +  +  L V+  P
Sbjct: 1501 TWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPP 1560



 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 62/223 (27%), Positives = 95/223 (42%), Gaps = 2/223 (0%)

Query: 506  LRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECA 565
            LR++ V     G Y C+ SN  GS    +  L V   P+   +P +LT+ A   A L C 
Sbjct: 2446 LRIQPVLAQDAGHYLCLASNSAGSDRQGR-DLRVLEPPAIAPSPSNLTLTAHTPALLPCE 2504

Query: 566  AVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSI 625
            A G P P + W KDG       ++    ++P + +        +D   + C   N  G  
Sbjct: 2505 ASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGP-QDSAQFECVVSNEVGEA 2563

Query: 626  SANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFF 685
                 +TV   P+      D TVT     VL C + G P P ++W+K  + L      + 
Sbjct: 2564 HRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYR 2623

Query: 686  AAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP 728
             + +  L I  +    AG+YTC   N+ G    +V L+V  +P
Sbjct: 2624 VSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASP 2666



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 67/245 (27%), Positives = 99/245 (40%), Gaps = 17/245 (6%)

Query: 496 GGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSF--TKTPMDLT 553
           G  +++    L    ++    G Y C   N  G++      L V   PS        ++ 
Sbjct: 79  GHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQR-DFHLLVLTPPSVLGAGAAQEVL 137

Query: 554 IRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGV 613
             AGA   L+C   G P PQ+ W KD     P      + V  +  V  I    + D G 
Sbjct: 138 GLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPH--LQVQEDGQVLRITGSHVGDEGR 195

Query: 614 YSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQ-------CIAGGSPPP 666
           Y C A + AG  + +  L V   P+        +   GE AV++       C A G P P
Sbjct: 196 YQCVAFSPAGQQARDFQLRVHAPPTIWG-----SNETGEVAVMEDHLVQLLCEARGVPTP 250

Query: 667 KLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIP 726
            + W KD + L  + +  +  G + L +  +  SDAG YTC+ SN +G      RL V  
Sbjct: 251 NITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYV 310

Query: 727 TPTCD 731
            PT +
Sbjct: 311 PPTIE 315



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 82/311 (26%), Positives = 121/311 (38%), Gaps = 26/311 (8%)

Query: 425 AVSPDGFVCDDFP-----KPQITVQPET-QSAIKGSNLSFICSAASSSDSPMTFAWKKDN 478
           A SP G    DF       P I    ET + A+   +L  +   A    +P    W KD 
Sbjct: 200 AFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTP-NITWFKDG 258

Query: 479 ELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLT 538
            LL  +    Y     +GG        L+L   + +  G Y C  SN  G++     +L 
Sbjct: 259 ALLPTSTKVVYT----RGGRQ------LQLGRAQSSDAGVYTCKASNAVGAAEKA-TRLD 307

Query: 539 VNMLPSFTKT---PMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVM 595
           V + P+       P  +   AG    LEC A GHP+P ++W  +G    P A      + 
Sbjct: 308 VYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEG---LPVAESNESRLE 364

Query: 596 PEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFL--RPLLDRTVTKGET 653
            +  V  +        G+YSC A + AG      ++ V   P  L    L   T   G+ 
Sbjct: 365 TDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQP 424

Query: 654 AVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTL 713
             L C A GSP P + W ++  P         A+    L I   ++  +G + C+ +N  
Sbjct: 425 LELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEA 484

Query: 714 GTERGNVRLSV 724
           GT    V +SV
Sbjct: 485 GTAGAEVEVSV 495



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 83/320 (25%), Positives = 124/320 (38%), Gaps = 40/320 (12%)

Query: 425  AVSPDGFVCDDFPKPQITVQPETQSA--------IKGSNLSFICSAASSSDSPMTFAWKK 476
            A SP G    +F   Q+ V P  +          ++GS +   C A      P+  +W K
Sbjct: 2104 AASPAGVADRNFTL-QVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVP-LPLV-SWMK 2160

Query: 477  DNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAK 536
            D E L    +E       QG         L+L  V     G Y CV  +  G +     +
Sbjct: 2161 DGEPLLSQSLE-------QGPS-------LQLEAVGAGDSGTYSCVAVSEAGEARR-HFQ 2205

Query: 537  LTVNMLPSFTKT--PMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHV 594
            LTV   P    +  P +L++  GA   L C A G P P I W KDG          R   
Sbjct: 2206 LTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATR 2265

Query: 595  MPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVT--KGE 652
            +          +++ D G+Y+C A++ AG+I  +  + V   P+ + P   R V      
Sbjct: 2266 V----------LRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPG 2315

Query: 653  TAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNT 712
              VL+C     P PK+ W +D   L       F    + L +     +D+G Y+C   N 
Sbjct: 2316 QLVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNA 2375

Query: 713  LGTERGNVRLSVIPTPTCDS 732
             G+     R+ +   PT  S
Sbjct: 2376 AGSTSVAFRVEIHTVPTIRS 2395



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 59/189 (31%), Positives = 80/189 (42%), Gaps = 15/189 (7%)

Query: 556 AGAMARLECAAVGHPAPQIAWQKDG------------GTDFPAARERRMHVMPEDDVFFI 603
           AG    LEC A G P P+I W KD             G D    +     ++ E      
Sbjct: 32  AGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHF 91

Query: 604 VDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTV--TKGETAVLQCIAG 661
             ++  D G+YSC A+N AG+   +  L VL  PS L     + V    G    LQC   
Sbjct: 92  PRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTS 151

Query: 662 GSPPPKLNWTKDDSPLVVTERHF-FAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNV 720
           G P P++ WTKD  P++    H       Q+L I  S V D G+Y C   +  G +  + 
Sbjct: 152 GVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDF 211

Query: 721 RLSVIPTPT 729
           +L V   PT
Sbjct: 212 QLRVHAPPT 220



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 76/299 (25%), Positives = 108/299 (36%), Gaps = 21/299 (7%)

Query: 439  PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 498
            P  T  P  +S   G  L   C AA  S +P    W  ++  + +   E        GG 
Sbjct: 2847 PVFTTLPGDRSLRLGDRLWLRC-AARGSPTPR-IGWTVNDRPVTEGVSEQ------DGGS 2898

Query: 499  VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIR-AG 557
             ++   + R         G Y C   N  G + +V   + V   P          +   G
Sbjct: 2899 TLQRAAVSR------EDSGTYVCWAENRVGRTQAVSF-VHVKEAPVLQGEAFSYLVEPVG 2951

Query: 558  AMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCT 617
               +L+C   G P P I W KDG    P       H + ++    I   + +D G Y C 
Sbjct: 2952 GSIQLDCVVRGDPVPDIHWIKDG---LPLRGSHLRHQL-QNGSLTIRRTERDDAGRYQCL 3007

Query: 618  AQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPL 677
            A+N  G       L +   P F     D TV  G+   L+C A G P P + W +   PL
Sbjct: 3008 AENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPL 3067

Query: 678  VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQMT 736
              + R      +  L + + +  DAG Y C   N LG+      L V   P      MT
Sbjct: 3068 RAS-RRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEPQGSWGSMT 3125



 Score = 74.7 bits (182), Expect = 4e-13
 Identities = 67/264 (25%), Positives = 107/264 (40%), Gaps = 27/264 (10%)

Query: 496 GGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYS-VKAKLTVNMLPSFTKTPMDL-- 552
           G +V    T L +  VE    G + C  +N  G++ + V+  +     P   + P+    
Sbjct: 453 GVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYH 512

Query: 553 -------TIRAGAMARLECAAVGHPAPQIA--WQKDGG-----TDFPAARERRMHVMPED 598
                  +  A     +      HP P +   W   G      T  P A     + +P  
Sbjct: 513 WGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVA-----YSLPPP 567

Query: 599 DVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQC 658
               I  V + D G+Y+C A N AG       L VL  P+     +++ V +  +  L+C
Sbjct: 568 --LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLEC 625

Query: 659 IAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTE-- 716
           +A G PPP ++W K   P+        +   ++L I  + +SDAG Y C  SN  G+   
Sbjct: 626 LASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTEL 685

Query: 717 RGNVRLSVIPTPTCDSPQMTAPSL 740
           R  +R++V P  T   P +  P L
Sbjct: 686 RYGLRVNVPPRITL-PPSLPGPVL 708



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 58/228 (25%), Positives = 93/228 (40%), Gaps = 21/228 (9%)

Query: 498 EVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSF--TKTPMDLTIR 555
           +V E   +LR+       EG+YQCV  +  G   +   +L V+  P+   +    ++ + 
Sbjct: 175 QVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQ-ARDFQLRVHAPPTIWGSNETGEVAVM 233

Query: 556 AGAMARLECAAVGHPAPQIAWQKDGG-----TDFPAARERRMHVMPEDDVFFIVDVKIED 610
              + +L C A G P P I W KDG      T     R  R   +           +  D
Sbjct: 234 EDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGR--------AQSSD 285

Query: 611 IGVYSCTAQNSAGSISANATLTVLETPSFL----RPLLDRTVTKGETAVLQCIAGGSPPP 666
            GVY+C A N+ G+      L V   P+      RP + + V  G    L+C+A G P P
Sbjct: 286 AGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVA-GRPVALECVARGHPSP 344

Query: 667 KLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLG 714
            L+W  +  P+  +          +L +     + +G Y+C  S+  G
Sbjct: 345 TLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAG 392



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 81/333 (24%), Positives = 131/333 (39%), Gaps = 45/333 (13%)

Query: 432  VCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAH 491
            +  D P  ++ V+ E ++ +  S L+  C   S +  P T  W KD + +  +       
Sbjct: 1353 ISKDDPLAEVGVK-EVKTKVN-STLTLECE--SWAVPPPTIRWYKDGQPVTPSSRL---- 1404

Query: 492  LRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKT--- 548
                  +V+    +L+++  + +  G+Y CV +N  G        + + + P F K    
Sbjct: 1405 ------QVLGEGRLLQIQPTQVSDSGRYLCVATNVAGED-DQDFNVLIQVPPMFQKVGDF 1457

Query: 549  -------PMDLTIRAGAM----------ARLECAAVGHPAPQIAWQKDGGTDFPAARERR 591
                     +   R G            A L C     P P + W ++   D P +    
Sbjct: 1458 SAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYRE---DQPLSAGDE 1514

Query: 592  MHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFL---RPLLDR-T 647
            + V+    V  I  V+ E+ G YSC A N  G    +  L VL  P  L     L++  T
Sbjct: 1515 VSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVT 1574

Query: 648  VTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTC 707
            V    T  LQC A G+P P ++W ++  P   + R       Q+L +  ++V+DA  Y C
Sbjct: 1575 VNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMC 1634

Query: 708  EMSNTLGTERGNVRLSVIPTPT---CDSPQMTA 737
               N  G+      L V   P     D  Q+TA
Sbjct: 1635 VAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTA 1667


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.133    0.396 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,463,178
Number of Sequences: 37866
Number of extensions: 1928290
Number of successful extensions: 13996
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 421
Number of HSP's successfully gapped in prelim test: 264
Number of HSP's that attempted gapping in prelim test: 4894
Number of HSP's gapped (non-prelim): 3986
length of query: 1059
length of database: 18,247,518
effective HSP length: 113
effective length of query: 946
effective length of database: 13,968,660
effective search space: 13214352360
effective search space used: 13214352360
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.