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Search of human proteins with 207029439
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|207029439 retinoblastoma binding protein 4 isoform c [Homo
sapiens]
(390 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|207029439 retinoblastoma binding protein 4 isoform c [Homo sa... 818 0.0
gi|207029415 retinoblastoma binding protein 4 isoform b [Homo sa... 818 0.0
gi|5032027 retinoblastoma binding protein 4 isoform a [Homo sapi... 818 0.0
gi|4506439 retinoblastoma binding protein 7 [Homo sapiens] 743 0.0
gi|237820620 glutamate-rich WD repeat containing 1 [Homo sapiens] 124 1e-28
gi|169165527 PREDICTED: similar to hCG1643855 [Homo sapiens] 120 2e-27
gi|239742072 PREDICTED: hypothetical protein LOC391556 [Homo sap... 120 2e-27
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 92 1e-18
gi|4505731 peroxisomal biogenesis factor 7 [Homo sapiens] 88 1e-17
gi|21071067 TBP-associated factor 5 [Homo sapiens] 85 1e-16
gi|217330644 WD repeat domain 12 protein [Homo sapiens] 82 8e-16
gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens] 80 3e-15
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 77 3e-14
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 77 3e-14
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 77 3e-14
gi|62234438 Notchless gene homolog isoform b [Homo sapiens] 77 3e-14
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 77 3e-14
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 76 5e-14
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 76 5e-14
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 76 5e-14
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] 76 5e-14
gi|109627650 coronin 6 [Homo sapiens] 75 1e-13
gi|21359963 ring finger and WD repeat domain 2 isoform a [Homo s... 75 1e-13
gi|50233824 ring finger and WD repeat domain 2 isoform d24 [Homo... 75 1e-13
gi|32189425 WD repeat domain 69 [Homo sapiens] 74 2e-13
gi|58331266 WD repeat domain 59 [Homo sapiens] 72 9e-13
gi|4757988 WD repeat domain 39 [Homo sapiens] 72 1e-12
gi|113865883 WD repeat domain 38 [Homo sapiens] 71 1e-12
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 71 1e-12
gi|4507703 tumor suppressing subtransferable candidate 1 [Homo s... 71 1e-12
>gi|207029439 retinoblastoma binding protein 4 isoform c [Homo
sapiens]
Length = 390
Score = 818 bits (2113), Expect = 0.0
Identities = 390/390 (100%), Positives = 390/390 (100%)
Query: 1 MTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDA 60
MTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDA
Sbjct: 1 MTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDA 60
Query: 61 SHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYT 120
SHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYT
Sbjct: 61 SHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYT 120
Query: 121 KHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGK 180
KHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGK
Sbjct: 121 KHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGK 180
Query: 181 VVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAE 240
VVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAE
Sbjct: 181 VVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAE 240
Query: 241 VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILAS 300
VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILAS
Sbjct: 241 VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILAS 300
Query: 301 SGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSE 360
SGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSE
Sbjct: 301 SGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSE 360
Query: 361 DNIMQVWQMAENIYNDEDPEGSVDPEGQGS 390
DNIMQVWQMAENIYNDEDPEGSVDPEGQGS
Sbjct: 361 DNIMQVWQMAENIYNDEDPEGSVDPEGQGS 390
>gi|207029415 retinoblastoma binding protein 4 isoform b [Homo
sapiens]
Length = 424
Score = 818 bits (2113), Expect = 0.0
Identities = 390/390 (100%), Positives = 390/390 (100%)
Query: 1 MTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDA 60
MTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDA
Sbjct: 35 MTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDA 94
Query: 61 SHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYT 120
SHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYT
Sbjct: 95 SHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYT 154
Query: 121 KHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGK 180
KHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGK
Sbjct: 155 KHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGK 214
Query: 181 VVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAE 240
VVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAE
Sbjct: 215 VVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAE 274
Query: 241 VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILAS 300
VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILAS
Sbjct: 275 VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILAS 334
Query: 301 SGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSE 360
SGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSE
Sbjct: 335 SGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSE 394
Query: 361 DNIMQVWQMAENIYNDEDPEGSVDPEGQGS 390
DNIMQVWQMAENIYNDEDPEGSVDPEGQGS
Sbjct: 395 DNIMQVWQMAENIYNDEDPEGSVDPEGQGS 424
>gi|5032027 retinoblastoma binding protein 4 isoform a [Homo
sapiens]
Length = 425
Score = 818 bits (2113), Expect = 0.0
Identities = 390/390 (100%), Positives = 390/390 (100%)
Query: 1 MTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDA 60
MTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDA
Sbjct: 36 MTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDA 95
Query: 61 SHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYT 120
SHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYT
Sbjct: 96 SHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYT 155
Query: 121 KHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGK 180
KHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGK
Sbjct: 156 KHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGK 215
Query: 181 VVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAE 240
VVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAE
Sbjct: 216 VVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAE 275
Query: 241 VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILAS 300
VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILAS
Sbjct: 276 VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILAS 335
Query: 301 SGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSE 360
SGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSE
Sbjct: 336 SGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSE 395
Query: 361 DNIMQVWQMAENIYNDEDPEGSVDPEGQGS 390
DNIMQVWQMAENIYNDEDPEGSVDPEGQGS
Sbjct: 396 DNIMQVWQMAENIYNDEDPEGSVDPEGQGS 425
>gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]
Length = 425
Score = 743 bits (1917), Expect = 0.0
Identities = 350/391 (89%), Positives = 372/391 (95%), Gaps = 1/391 (0%)
Query: 1 MTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDA 60
MTHAL+WPSLT QWLP+VT+PEGKD+++H LVLGTHTSDEQNHLV+A V +PNDDAQFDA
Sbjct: 35 MTHALQWPSLTVQWLPEVTKPEGKDYALHWLVLGTHTSDEQNHLVVARVHIPNDDAQFDA 94
Query: 61 SHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYT 120
SH DS+KGEFGGFGSV+GKIE EIKINHEGEVNRARYMPQNP IIATKTPSSDVLVFDYT
Sbjct: 95 SHCDSDKGEFGGFGSVTGKIECEIKINHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYT 154
Query: 121 KHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGK 180
KHP+KPDPSGECNPDLRLRGHQKEGYGLSWN NLSGHLLSASDDHT+CLWDI+A PKEGK
Sbjct: 155 KHPAKPDPSGECNPDLRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGK 214
Query: 181 VVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAE 240
+VDAK IFTGH+AVVEDV+WHLLHESLFGSVADDQKLMIWDTRSN TSKPSH VDAHTAE
Sbjct: 215 IVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAE 274
Query: 241 VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILAS 300
VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH+FESHKDEIFQV WSPHNETILAS
Sbjct: 275 VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILAS 334
Query: 301 SGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSE 360
SGTDRRLNVWDLSKIGEEQS EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSE
Sbjct: 335 SGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSE 394
Query: 361 DNIMQVWQMAENIYNDEDPEGSV-DPEGQGS 390
DNIMQ+WQMAENIYNDE+ + + + EGQGS
Sbjct: 395 DNIMQIWQMAENIYNDEESDVTTSELEGQGS 425
>gi|237820620 glutamate-rich WD repeat containing 1 [Homo sapiens]
Length = 446
Score = 124 bits (312), Expect = 1e-28
Identities = 73/243 (30%), Positives = 122/243 (50%), Gaps = 17/243 (6%)
Query: 127 DPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKV--VDA 184
D + P GH EG+ L W+P ++G LL+ I LW P +G VD
Sbjct: 199 DEQAQMKPIFSFAGHMGEGFALDWSPRVTGRLLTGDCQKNIHLW----TPTDGGSWHVDQ 254
Query: 185 KTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTR-SNNTSKPSHSVDAHTAEVNC 243
+ F GHT VED+ W ++F S + D + IWD R + + + + AH +VN
Sbjct: 255 RP-FVGHTRSVEDLQWSPTENTVFASCSADASIRIWDIRAAPSKACMLTTATAHDGDVNV 313
Query: 244 LSFNPYSEFILATGSADKTVALWDLRNLK--LKLHSFESHKDEIFQVQWSPHNETILASS 301
+S++ F+L +G D + +WDLR K + +F+ H + V+W P + + A+S
Sbjct: 314 ISWSRREPFLL-SGGDDGALKIWDLRQFKSGSPVATFKQHVAPVTSVEWHPQDSGVFAAS 372
Query: 302 GTDRRLNVWDLS-----KIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVIC 356
G D ++ WDL+ + G+ ++ D P +LLF+H G T ++ + W+P P ++
Sbjct: 373 GADHQITQWDLAVERDPEAGDVEADPGLADLPQQLLFVHQGET-ELKELHWHPQCPGLLV 431
Query: 357 SVS 359
S +
Sbjct: 432 STA 434
Score = 43.9 bits (102), Expect = 2e-04
Identities = 26/98 (26%), Positives = 42/98 (42%), Gaps = 16/98 (16%)
Query: 275 LHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGE---EQSPEDAEDGPPEL 331
+ SF H E F + WSP L + + +++W + G +Q P
Sbjct: 207 IFSFAGHMGEGFALDWSPRVTGRLLTGDCQKNIHLWTPTDGGSWHVDQRP---------- 256
Query: 332 LFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 369
F+ GHT + D W+P E V S S D +++W +
Sbjct: 257 -FV--GHTRSVEDLQWSPTENTVFASCSADASIRIWDI 291
Score = 42.7 bits (99), Expect = 6e-04
Identities = 32/136 (23%), Positives = 52/136 (38%), Gaps = 11/136 (8%)
Query: 86 INHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEG 145
+ H V ++ P + A+ + + + ++D PSK H +
Sbjct: 258 VGHTRSVEDLQWSPTENTVFASCSADASIRIWDIRAAPSKACMLTTAT------AHDGDV 311
Query: 146 YGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHE 205
+SW+ LLS DD + +WD+ K G V F H A V V WH
Sbjct: 312 NVISWS-RREPFLLSGGDDGALKIWDLRQF-KSGSPV---ATFKQHVAPVTSVEWHPQDS 366
Query: 206 SLFGSVADDQKLMIWD 221
+F + D ++ WD
Sbjct: 367 GVFAASGADHQITQWD 382
>gi|169165527 PREDICTED: similar to hCG1643855 [Homo sapiens]
Length = 103
Score = 120 bits (301), Expect = 2e-27
Identities = 59/72 (81%), Positives = 62/72 (86%), Gaps = 4/72 (5%)
Query: 1 MTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDA 60
MT ALEWPSLTAQWLPDVTRPEGKDFS HRLV GTHTS EQNHL VQLP+DDAQ DA
Sbjct: 36 MTQALEWPSLTAQWLPDVTRPEGKDFSSHRLVPGTHTSVEQNHL----VQLPSDDAQLDA 91
Query: 61 SHYDSEKGEFGG 72
SHY+S+KGE GG
Sbjct: 92 SHYNSKKGECGG 103
>gi|239742072 PREDICTED: hypothetical protein LOC391556 [Homo
sapiens]
Length = 103
Score = 120 bits (301), Expect = 2e-27
Identities = 59/72 (81%), Positives = 62/72 (86%), Gaps = 4/72 (5%)
Query: 1 MTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDA 60
MT ALEWPSLTAQWLPDVTRPEGKDFS HRLV GTHTS EQNHL VQLP+DDAQ DA
Sbjct: 36 MTQALEWPSLTAQWLPDVTRPEGKDFSSHRLVPGTHTSVEQNHL----VQLPSDDAQLDA 91
Query: 61 SHYDSEKGEFGG 72
SHY+S+KGE GG
Sbjct: 92 SHYNSKKGECGG 103
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 91.7 bits (226), Expect = 1e-18
Identities = 77/247 (31%), Positives = 118/247 (47%), Gaps = 35/247 (14%)
Query: 138 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 197
LRGH Y + + SG LLS S+D +I WD+ + ++ GH V D
Sbjct: 338 LRGHCGPVYSTRFLADSSG-LLSCSEDMSIRYWDLGSFTNT-------VLYQGHAYPVWD 389
Query: 198 --VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILA 255
+S + L+ F S + D+ +W S + + P H A+V+C+ F+P S + LA
Sbjct: 390 LDISPYSLY---FASGSHDRTARLW---SFDRTYPLRIYAGHLADVDCVKFHPNSNY-LA 442
Query: 256 TGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKI 315
TGS DKTV LW + + F H+ + + +SP N LAS+G D+RL +WDL+
Sbjct: 443 TGSTDKTVRLWSAQQGN-SVRLFTGHRGPVLSLAFSP-NGKYLASAGEDQRLKLWDLAS- 499
Query: 316 GEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYN 375
L GHT I+ +++P + +I S S DN ++VW + N Y
Sbjct: 500 -------------GTLYKELRGHTDNITSLTFSP-DSGLIASASMDNSVRVWDI-RNTYC 544
Query: 376 DEDPEGS 382
+GS
Sbjct: 545 SAPADGS 551
>gi|4505731 peroxisomal biogenesis factor 7 [Homo sapiens]
Length = 323
Score = 88.2 bits (217), Expect = 1e-17
Identities = 63/231 (27%), Positives = 101/231 (43%), Gaps = 24/231 (10%)
Query: 141 HQKEGYGLSWNPNLSGHLL-SASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 199
H +E Y + W+ L+ S S D T+ LWD P GK + F GH +++
Sbjct: 110 HAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWD----PTVGKSL---CTFRGHESIIYSTI 162
Query: 200 WHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSA 259
W F S + DQ L IWD ++ + AH AE+ + Y+E +L TG+
Sbjct: 163 WSPHIPGCFASASGDQTLRIWDVKAAGVRIV---IPAHQAEILSCDWCKYNENLLVTGAV 219
Query: 260 DKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQ 319
D ++ WDLRN++ + H I +V++SP + ++LAS D + W+ SK
Sbjct: 220 DCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSK----- 274
Query: 320 SPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMA 370
P LL HT ++ P + S D ++++ A
Sbjct: 275 --------PDSLLETVEHHTEFTCGLDFSLQSPTQVADCSWDETIKIYDPA 317
Score = 79.0 bits (193), Expect = 7e-15
Identities = 47/173 (27%), Positives = 78/173 (45%), Gaps = 9/173 (5%)
Query: 139 RGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDV 198
RGH+ Y W+P++ G SAS D T+ +WD+ K + + H A +
Sbjct: 152 RGHESIIYSTIWSPHIPGCFASASGDQTLRIWDV-------KAAGVRIVIPAHQAEILSC 204
Query: 199 SWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGS 258
W +E+L + A D L WD R N +P + HT + + F+P+ +LA+ S
Sbjct: 205 DWCKYNENLLVTGAVDCSLRGWDLR--NVRQPVFELLGHTYAIRRVKFSPFHASVLASCS 262
Query: 259 ADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 311
D TV W+ L + E H + + +S + T +A D + ++D
Sbjct: 263 YDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPTQVADCSWDETIKIYD 315
Score = 72.8 bits (177), Expect = 5e-13
Identities = 54/227 (23%), Positives = 97/227 (42%), Gaps = 24/227 (10%)
Query: 146 YGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLH- 204
+ ++W+ N L++ S D ++ LWD + K ++ H V V W
Sbjct: 71 FDVTWSENNEHVLITCSGDGSLQLWDTA------KAAGPLQVYKEHAQEVYSVDWSQTRG 124
Query: 205 ESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVA 264
E L S + DQ + +WD K + H + + ++P+ A+ S D+T+
Sbjct: 125 EQLVVSGSWDQTVKLWDP---TVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLR 181
Query: 265 LWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDA 324
+WD++ +++ +H+ EI W +NE +L + D L WDL + +
Sbjct: 182 IWDVKAAGVRI-VIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVF---- 236
Query: 325 EDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 371
ELL GHT I ++P V+ S S D ++ W ++
Sbjct: 237 -----ELL----GHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSK 274
Score = 65.5 bits (158), Expect = 8e-11
Identities = 52/187 (27%), Positives = 85/187 (45%), Gaps = 17/187 (9%)
Query: 138 LRGHQKEGYGLSWNPNLSGHLLSASDDH-------TICLWDISAVPKEGKVVDAKTIFTG 190
LR + GY ++P L G L A+ H T+ + D P E + ++ F
Sbjct: 12 LRTPGRHGYAAEFSPYLPGRLACATAQHYGIAGCGTLLILD----PDEAGLRLFRS-FDW 66
Query: 191 HTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFN-PY 249
+ + DV+W +E + + + D L +WDT + P H EV + ++
Sbjct: 67 NDGLF-DVTWSENNEHVLITCSGDGSLQLWDTA--KAAGPLQVYKEHAQEVYSVDWSQTR 123
Query: 250 SEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNV 309
E ++ +GS D+TV LWD + L +F H+ I+ WSPH AS+ D+ L +
Sbjct: 124 GEQLVVSGSWDQTVKLWD-PTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRI 182
Query: 310 WDLSKIG 316
WD+ G
Sbjct: 183 WDVKAAG 189
Score = 42.7 bits (99), Expect = 6e-04
Identities = 39/162 (24%), Positives = 61/162 (37%), Gaps = 38/162 (23%)
Query: 246 FNPYSEFILATGSADK-------TVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETIL 298
F+PY LA +A T+ + D L+L D +F V WS +NE +L
Sbjct: 24 FSPYLPGRLACATAQHYGIAGCGTLLILDPDEAGLRLFRSFDWNDGLFDVTWSENNEHVL 83
Query: 299 ASSGTDRRLNVWDLSK------IGEEQSPE----DAEDGPPELLFIHG------------ 336
+ D L +WD +K + +E + E D E L + G
Sbjct: 84 ITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDPT 143
Query: 337 ---------GHTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 369
GH + I W+P+ P S S D +++W +
Sbjct: 144 VGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDV 185
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 84.7 bits (208), Expect = 1e-16
Identities = 69/233 (29%), Positives = 110/233 (47%), Gaps = 36/233 (15%)
Query: 138 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 197
L GH YG S++P+ + +LLS+S+D T+ LW + + + GH V D
Sbjct: 539 LYGHSGPVYGASFSPDRN-YLLSSSEDGTVRLWSL-------QTFTCLVGYKGHNYPVWD 590
Query: 198 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 257
+ + F S D+ +W T + +P H A+VNC F+P S ++ ATG
Sbjct: 591 TQFSP-YGYYFVSGGHDRVARLWAT---DHYQPLRIFAGHLADVNCTRFHPNSNYV-ATG 645
Query: 258 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLS---K 314
SAD+TV LWD+ N + F HK I + +SP N LA+ TD R+ +WD+
Sbjct: 646 SADRTVRLWDVLNGNC-VRIFTGHKGPIHSLTFSP-NGRFLATGATDGRVLLWDIGHGLM 703
Query: 315 IGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 367
+GE + GHT + ++ + ++ S S DN +++W
Sbjct: 704 VGELK-----------------GHTDTVCSLRFS-RDGEILASGSMDNTVRLW 738
Score = 47.0 bits (110), Expect = 3e-05
Identities = 39/128 (30%), Positives = 60/128 (46%), Gaps = 13/128 (10%)
Query: 140 GHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 199
GH + ++PN S ++ + S D T+ LWD+ G V IFTGH + ++
Sbjct: 625 GHLADVNCTRFHPN-SNYVATGSADRTVRLWDVL----NGNCV---RIFTGHKGPIHSLT 676
Query: 200 WHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSA 259
+ + + A D ++++WD + HT V L F+ E ILA+GS
Sbjct: 677 FSP-NGRFLATGATDGRVLLWDI---GHGLMVGELKGHTDTVCSLRFSRDGE-ILASGSM 731
Query: 260 DKTVALWD 267
D TV LWD
Sbjct: 732 DNTVRLWD 739
>gi|217330644 WD repeat domain 12 protein [Homo sapiens]
Length = 423
Score = 82.0 bits (201), Expect = 8e-16
Identities = 54/174 (31%), Positives = 90/174 (51%), Gaps = 13/174 (7%)
Query: 134 PDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTA 193
P + L GH + + W+ + + SAS DHTI +WD+ + K+ TG+
Sbjct: 249 PIVTLSGHMEAVSSVLWSD--AEEICSASWDHTIRVWDVESG-------SLKSTLTGNK- 298
Query: 194 VVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFI 253
V +S+ L + L S + D+ + +WD R+ + S S S+ +HT V + ++P E
Sbjct: 299 VFNCISYSPLCKRL-ASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQ 357
Query: 254 LATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 307
L +GS D V LWD R+ K L+ +H+D++ V W+ + +L S G D +L
Sbjct: 358 LISGSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSVDWT--DTGLLLSGGADNKL 409
Score = 58.9 bits (141), Expect = 7e-09
Identities = 46/170 (27%), Positives = 71/170 (41%), Gaps = 16/170 (9%)
Query: 189 TGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNP 248
+GH V V W E S + D + +WD S + S NC+S++P
Sbjct: 254 SGHMEAVSSVLWSDAEEIC--SASWDHTIRVWDVESGSLK----STLTGNKVFNCISYSP 307
Query: 249 YSEFILATGSADKTVALWDLRNLKLKLHSFE--SHKDEIFQVQWSPHNETILASSGTDRR 306
+ LA+GS D+ + LWD R L S SH + V+WSP +E L S D
Sbjct: 308 LCKR-LASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNI 366
Query: 307 LNVWD-------LSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNP 349
+ +WD L + + + D L + GG K+ + ++P
Sbjct: 367 VKLWDTRSCKAPLYDLAAHEDKVLSVDWTDTGLLLSGGADNKLYSYRYSP 416
Score = 55.5 bits (132), Expect = 8e-08
Identities = 67/254 (26%), Positives = 107/254 (42%), Gaps = 47/254 (18%)
Query: 140 GHQKEGYGLSW--NPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 197
GH ++W +LS LLSAS D TI LW+ + E V A GH V+
Sbjct: 138 GHTDVVKDVAWVKKDSLSCLLLSASMDQTILLWEWNV---ERNKVKALHCCRGHAGSVDS 194
Query: 198 VSWHLLHESLFGSVADDQKLMIWDT----------RSNN-------------TSKPSHSV 234
++ + F S + D+ L IW T S N T P ++
Sbjct: 195 IAVDG-SGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNRPRKKQKTEQLGLTRTPIVTL 253
Query: 235 DAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQ-VQWSPH 293
H V+ + ++ E + + S D T+ +WD+ + LK + +K +F + +SP
Sbjct: 254 SGHMEAVSSVLWSDAEE--ICSASWDHTIRVWDVESGSLK-STLTGNK--VFNCISYSPL 308
Query: 294 NETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPW 353
+ LAS TDR + +WD +DG L + HT ++ W+P
Sbjct: 309 CKR-LASGSTDRHIRLWD----------PRTKDGSLVSLSLTS-HTGWVTSVKWSPTHEQ 356
Query: 354 VICSVSEDNIMQVW 367
+ S S DNI+++W
Sbjct: 357 QLISGSLDNIVKLW 370
Score = 45.1 bits (105), Expect = 1e-04
Identities = 62/290 (21%), Positives = 101/290 (34%), Gaps = 86/290 (29%)
Query: 98 MPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGH 157
MP + + S +V+ +Y + + P P +C + W ++ G
Sbjct: 64 MPLDKHMEMENISSEEVVEIEYVEKYTAPQPE-QCM------------FHDDWISSIKGA 110
Query: 158 ---LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADD 214
+L+ S D T +W + EGK + GHT VV+DV+W
Sbjct: 111 EEWILTGSYDKTSRIWSL-----EGKSI---MTIVGHTDVVKDVAW-------------- 148
Query: 215 QKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL---RNL 271
K S ++CL L + S D+T+ LW+ RN
Sbjct: 149 ------------VKKDS---------LSCL---------LLSASMDQTILLWEWNVERNK 178
Query: 272 KLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPEL 331
LH H + + T S D+ L +W EE E++ + P +
Sbjct: 179 VKALHCCRGHAGSVDSIAVDGSG-TKFCSGSWDKMLKIWSTVPTDEEDEMEESTNRPRKK 237
Query: 332 ------------LFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 369
+ GH +S W+ E ICS S D+ ++VW +
Sbjct: 238 QKTEQLGLTRTPIVTLSGHMEAVSSVLWSDAEE--ICSASWDHTIRVWDV 285
Score = 36.2 bits (82), Expect = 0.052
Identities = 32/137 (23%), Positives = 54/137 (39%), Gaps = 16/137 (11%)
Query: 251 EFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHN--ETILASSGTDRRLN 308
E+IL TGS DKT +W L + + H D + V W + +L S+ D+ +
Sbjct: 112 EWIL-TGSYDKTSRIWSLEGKSIM--TIVGHTDVVKDVAWVKKDSLSCLLLSASMDQTIL 168
Query: 309 VWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQ 368
+W+ + E + L GH + + + CS S D ++++W
Sbjct: 169 LWEW----------NVERNKVKALHCCRGHAGSVDSIAVD-GSGTKFCSGSWDKMLKIWS 217
Query: 369 MAENIYNDEDPEGSVDP 385
DE E + P
Sbjct: 218 TVPTDEEDEMEESTNRP 234
>gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]
Length = 1336
Score = 80.1 bits (196), Expect = 3e-15
Identities = 64/209 (30%), Positives = 92/209 (44%), Gaps = 26/209 (12%)
Query: 160 SASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLF-GSVADDQKLM 218
+ SDD T+ +WD +E I GH A V+ V WH + GS Q +
Sbjct: 219 TCSDDGTVRIWDFLRCHEE-------RILRGHGADVKCVDWHPTKGLVVSGSKDSQQPIK 271
Query: 219 IWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSF 278
WD ++ + H AH V + N ++L T S D L+D+RNLK +L F
Sbjct: 272 FWDPKTGQSLATLH---AHKNTVMEVKLNLNGNWLL-TASRDHLCKLFDIRNLKEELQVF 327
Query: 279 ESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGH 338
HK E V W P +E + AS G+D L W +G E+ E G E+ H
Sbjct: 328 RGHKKEATAVAWHPVHEGLFASGGSDGSLLFW---HVGVEK-----EVGGMEM-----AH 374
Query: 339 TAKISDFSWNPNEPWVICSVSEDNIMQVW 367
I +W+P ++CS S D+ + W
Sbjct: 375 EGMIWSLAWHP-LGHILCSGSNDHTSKFW 402
Score = 47.8 bits (112), Expect = 2e-05
Identities = 44/234 (18%), Positives = 101/234 (43%), Gaps = 31/234 (13%)
Query: 138 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 197
L+ H ++W+ N +L+A + W + ++ +F H + +
Sbjct: 157 LQAHDSPVRAMTWSHN-DMWMLTADHGGYVKYWQSN--------MNNVKMFQAHKEAIRE 207
Query: 198 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 257
S+ ++ F + +DD + IWD + + + H A+V C+ ++P ++ ++ +G
Sbjct: 208 ASFSPT-DNKFATCSDDGTVRIWDFLRCHEER---ILRGHGADVKCVDWHP-TKGLVVSG 262
Query: 258 SAD--KTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKI 315
S D + + WD + + L + +HK+ + +V+ + + +L +S D ++D+ +
Sbjct: 263 SKDSQQPIKFWDPKTGQ-SLATLHAHKNTVMEVKLNLNGNWLLTAS-RDHLCKLFDIRNL 320
Query: 316 GEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 369
EE L + GH + + +W+P + S D + W +
Sbjct: 321 KEE-------------LQVFRGHKKEATAVAWHPVHEGLFASGGSDGSLLFWHV 361
Score = 36.6 bits (83), Expect = 0.040
Identities = 21/82 (25%), Positives = 36/82 (43%), Gaps = 7/82 (8%)
Query: 139 RGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDV 198
RGH+KE ++W+P G S D ++ W + + G + A H ++ +
Sbjct: 328 RGHKKEATAVAWHPVHEGLFASGGSDGSLLFWHVGVEKEVGGMEMA------HEGMIWSL 381
Query: 199 SWHLLHESLFGSVADDQKLMIW 220
+WH L L S ++D W
Sbjct: 382 AWHPLGHILC-SGSNDHTSKFW 402
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 77.0 bits (188), Expect = 3e-14
Identities = 68/236 (28%), Positives = 116/236 (49%), Gaps = 32/236 (13%)
Query: 137 RLRGHQKEGYGLSWNPNLSGHLL-SASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVV 195
R GH+ ++++P SGHLL S S D T+ +W VP V T+F HTA V
Sbjct: 18 RFTGHKDAVTCVNFSP--SGHLLASGSRDKTVRIW----VPN---VKGESTVFRAHTATV 68
Query: 196 EDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILA 255
V + +S F + +DD+ + +W T + K S+ H V C F+P I++
Sbjct: 69 RSVHFCSDGQS-FVTASDDKTVKVWAT---HRQKFLFSLSQHINWVRCAKFSPDGRLIVS 124
Query: 256 TGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKI 315
S DKTV LWD ++ + +HS+ H + V + P + T +A++G D + VWD+
Sbjct: 125 A-SDDKTVKLWD-KSSRECVHSYCEHGGFVTYVDFHP-SGTCIAAAGMDNTVKVWDVR-- 179
Query: 316 GEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 371
LL + H+A ++ S++P+ ++I + S D+ +++ + E
Sbjct: 180 ------------THRLLQHYQLHSAAVNGLSFHPSGNYLI-TASSDSTLKILDLME 222
Score = 57.4 bits (137), Expect = 2e-08
Identities = 45/153 (29%), Positives = 73/153 (47%), Gaps = 14/153 (9%)
Query: 158 LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKL 217
++SASDD T+ LWD S+ + + H V V +H + + D +
Sbjct: 122 IVSASDDKTVKLWDKSS-------RECVHSYCEHGGFVTYVDFH-PSGTCIAAAGMDNTV 173
Query: 218 MIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHS 277
+WD R T + H+A VN LSF+P +++ T S+D T+ + DL +L L++
Sbjct: 174 KVWDVR---THRLLQHYQLHSAAVNGLSFHPSGNYLI-TASSDSTLKILDLMEGRL-LYT 228
Query: 278 FESHKDEIFQVQWSPHNETILASSGTDRRLNVW 310
H+ V +S E AS G+D ++ VW
Sbjct: 229 LHGHQGPATTVAFSRTGE-YFASGGSDEQVMVW 260
Score = 46.6 bits (109), Expect = 4e-05
Identities = 37/154 (24%), Positives = 71/154 (46%), Gaps = 21/154 (13%)
Query: 214 DQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKL 273
D LM+W + + + + H V C++F+P S +LA+GS DKTV +W + N+K
Sbjct: 2 DSCLMVWHMKPQSRA---YRFTGHKDAVTCVNFSP-SGHLLASGSRDKTVRIW-VPNVKG 56
Query: 274 KLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLF 333
+ F +H + V + ++ + +S D+ + VW + + LF
Sbjct: 57 ESTVFRAHTATVRSVHFCSDGQSFVTAS-DDKTVKVWATHR--------------QKFLF 101
Query: 334 IHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 367
H + ++P + +I S S+D +++W
Sbjct: 102 SLSQHINWVRCAKFSP-DGRLIVSASDDKTVKLW 134
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 77.0 bits (188), Expect = 3e-14
Identities = 68/236 (28%), Positives = 116/236 (49%), Gaps = 32/236 (13%)
Query: 137 RLRGHQKEGYGLSWNPNLSGHLL-SASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVV 195
R GH+ ++++P SGHLL S S D T+ +W VP V T+F HTA V
Sbjct: 56 RFTGHKDAVTCVNFSP--SGHLLASGSRDKTVRIW----VPN---VKGESTVFRAHTATV 106
Query: 196 EDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILA 255
V + +S F + +DD+ + +W T + K S+ H V C F+P I++
Sbjct: 107 RSVHFCSDGQS-FVTASDDKTVKVWAT---HRQKFLFSLSQHINWVRCAKFSPDGRLIVS 162
Query: 256 TGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKI 315
S DKTV LWD ++ + +HS+ H + V + P + T +A++G D + VWD+
Sbjct: 163 A-SDDKTVKLWD-KSSRECVHSYCEHGGFVTYVDFHP-SGTCIAAAGMDNTVKVWDVR-- 217
Query: 316 GEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 371
LL + H+A ++ S++P+ ++I + S D+ +++ + E
Sbjct: 218 ------------THRLLQHYQLHSAAVNGLSFHPSGNYLI-TASSDSTLKILDLME 260
Score = 57.4 bits (137), Expect = 2e-08
Identities = 45/153 (29%), Positives = 73/153 (47%), Gaps = 14/153 (9%)
Query: 158 LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKL 217
++SASDD T+ LWD S+ + + H V V +H + + D +
Sbjct: 160 IVSASDDKTVKLWDKSS-------RECVHSYCEHGGFVTYVDFH-PSGTCIAAAGMDNTV 211
Query: 218 MIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHS 277
+WD R T + H+A VN LSF+P +++ T S+D T+ + DL +L L++
Sbjct: 212 KVWDVR---THRLLQHYQLHSAAVNGLSFHPSGNYLI-TASSDSTLKILDLMEGRL-LYT 266
Query: 278 FESHKDEIFQVQWSPHNETILASSGTDRRLNVW 310
H+ V +S E AS G+D ++ VW
Sbjct: 267 LHGHQGPATTVAFSRTGE-YFASGGSDEQVMVW 298
Score = 50.1 bits (118), Expect = 3e-06
Identities = 44/180 (24%), Positives = 82/180 (45%), Gaps = 22/180 (12%)
Query: 188 FTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFN 247
F GH V V + + + L S + D LM+W + + + + H V C++F+
Sbjct: 15 FKGHRDAVTCVDFSINTKQL-ASGSMDSCLMVWHMKPQSRA---YRFTGHKDAVTCVNFS 70
Query: 248 PYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 307
P S +LA+GS DKTV +W + N+K + F +H + V + ++ + +S D+ +
Sbjct: 71 P-SGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTAS-DDKTV 127
Query: 308 NVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 367
VW + + LF H + ++P + +I S S+D +++W
Sbjct: 128 KVWATHR--------------QKFLFSLSQHINWVRCAKFSP-DGRLIVSASDDKTVKLW 172
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 77.0 bits (188), Expect = 3e-14
Identities = 68/236 (28%), Positives = 116/236 (49%), Gaps = 32/236 (13%)
Query: 137 RLRGHQKEGYGLSWNPNLSGHLL-SASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVV 195
R GH+ ++++P SGHLL S S D T+ +W VP V T+F HTA V
Sbjct: 56 RFTGHKDAVTCVNFSP--SGHLLASGSRDKTVRIW----VPN---VKGESTVFRAHTATV 106
Query: 196 EDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILA 255
V + +S F + +DD+ + +W T + K S+ H V C F+P I++
Sbjct: 107 RSVHFCSDGQS-FVTASDDKTVKVWAT---HRQKFLFSLSQHINWVRCAKFSPDGRLIVS 162
Query: 256 TGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKI 315
S DKTV LWD ++ + +HS+ H + V + P + T +A++G D + VWD+
Sbjct: 163 A-SDDKTVKLWD-KSSRECVHSYCEHGGFVTYVDFHP-SGTCIAAAGMDNTVKVWDVR-- 217
Query: 316 GEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 371
LL + H+A ++ S++P+ ++I + S D+ +++ + E
Sbjct: 218 ------------THRLLQHYQLHSAAVNGLSFHPSGNYLI-TASSDSTLKILDLME 260
Score = 57.4 bits (137), Expect = 2e-08
Identities = 45/153 (29%), Positives = 73/153 (47%), Gaps = 14/153 (9%)
Query: 158 LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKL 217
++SASDD T+ LWD S+ + + H V V +H + + D +
Sbjct: 160 IVSASDDKTVKLWDKSS-------RECVHSYCEHGGFVTYVDFH-PSGTCIAAAGMDNTV 211
Query: 218 MIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHS 277
+WD R T + H+A VN LSF+P +++ T S+D T+ + DL +L L++
Sbjct: 212 KVWDVR---THRLLQHYQLHSAAVNGLSFHPSGNYLI-TASSDSTLKILDLMEGRL-LYT 266
Query: 278 FESHKDEIFQVQWSPHNETILASSGTDRRLNVW 310
H+ V +S E AS G+D ++ VW
Sbjct: 267 LHGHQGPATTVAFSRTGE-YFASGGSDEQVMVW 298
Score = 50.1 bits (118), Expect = 3e-06
Identities = 44/180 (24%), Positives = 82/180 (45%), Gaps = 22/180 (12%)
Query: 188 FTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFN 247
F GH V V + + + L S + D LM+W + + + + H V C++F+
Sbjct: 15 FKGHRDAVTCVDFSINTKQL-ASGSMDSCLMVWHMKPQSRA---YRFTGHKDAVTCVNFS 70
Query: 248 PYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 307
P S +LA+GS DKTV +W + N+K + F +H + V + ++ + +S D+ +
Sbjct: 71 P-SGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTAS-DDKTV 127
Query: 308 NVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 367
VW + + LF H + ++P + +I S S+D +++W
Sbjct: 128 KVWATHR--------------QKFLFSLSQHINWVRCAKFSP-DGRLIVSASDDKTVKLW 172
>gi|62234438 Notchless gene homolog isoform b [Homo sapiens]
Length = 193
Score = 76.6 bits (187), Expect = 3e-14
Identities = 51/153 (33%), Positives = 80/153 (52%), Gaps = 13/153 (8%)
Query: 158 LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKL 217
L+S SDD T+ LW P E K T TGH A++ V + + S + D+ +
Sbjct: 52 LVSGSDDFTLFLWS----PAEDK--KPLTRMTGHQALINQVLFSP-DSRIVASASFDKSI 104
Query: 218 MIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHS 277
+WD R T K S+ H A V ++++ S +L +GS+D T+ +WD++ KL +
Sbjct: 105 KLWDGR---TGKYLASLRGHVAAVYQIAWSADSR-LLVSGSSDSTLKVWDVKAQKLAM-D 159
Query: 278 FESHKDEIFQVQWSPHNETILASSGTDRRLNVW 310
H DE++ V WSP + + AS G D+ L +W
Sbjct: 160 LPGHADEVYAVDWSPDGQRV-ASGGKDKCLRIW 191
Score = 42.7 bits (99), Expect = 6e-04
Identities = 39/142 (27%), Positives = 66/142 (46%), Gaps = 23/142 (16%)
Query: 254 LATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLS 313
L +GS D T+ LW K L H+ I QV +SP + I+AS+ D+ + +WD
Sbjct: 52 LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSP-DSRIVASASFDKSIKLWD-G 109
Query: 314 KIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW-----Q 368
+ G + L GH A + +W+ + ++ S S D+ ++VW +
Sbjct: 110 RTG-------------KYLASLRGHVAAVYQIAWSADSR-LLVSGSSDSTLKVWDVKAQK 155
Query: 369 MAENIYNDEDPEGSVD--PEGQ 388
+A ++ D +VD P+GQ
Sbjct: 156 LAMDLPGHADEVYAVDWSPDGQ 177
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 76.6 bits (187), Expect = 3e-14
Identities = 51/153 (33%), Positives = 80/153 (52%), Gaps = 13/153 (8%)
Query: 158 LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKL 217
L+S SDD T+ LW P E K T TGH A++ V + + S + D+ +
Sbjct: 344 LVSGSDDFTLFLWS----PAEDK--KPLTRMTGHQALINQVLFSP-DSRIVASASFDKSI 396
Query: 218 MIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHS 277
+WD R T K S+ H A V ++++ S +L +GS+D T+ +WD++ KL +
Sbjct: 397 KLWDGR---TGKYLASLRGHVAAVYQIAWSADSR-LLVSGSSDSTLKVWDVKAQKLAM-D 451
Query: 278 FESHKDEIFQVQWSPHNETILASSGTDRRLNVW 310
H DE++ V WSP + + AS G D+ L +W
Sbjct: 452 LPGHADEVYAVDWSPDGQRV-ASGGKDKCLRIW 483
Score = 57.4 bits (137), Expect = 2e-08
Identities = 74/314 (23%), Positives = 123/314 (39%), Gaps = 80/314 (25%)
Query: 127 DPSGECNPDLRLRGHQKEGYGLSWNPNLSG----HLLSASDDHTICLWDISAVPKEGKVV 182
DPS L GH K GLSW P + ++ S+S D ++ +WD +A G+
Sbjct: 184 DPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTA----GR-- 237
Query: 183 DAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVN 242
+ I TGHT V + W + L S + D+ + +W + ++ H VN
Sbjct: 238 -CERILTGHTQSVTCLRWG--GDGLLYSASQDRTIKVWRAHDGVLCR---TLQGHGHWVN 291
Query: 243 CL-----------SFNPYSEFI------------------------------LATGSADK 261
+ +F P + L +GS D
Sbjct: 292 TMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDF 351
Query: 262 TVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSP 321
T+ LW K L H+ I QV +SP + I+AS+ D+ + +WD + G
Sbjct: 352 TLFLWSPAEDKKPLTRMTGHQALINQVLFSP-DSRIVASASFDKSIKLWD-GRTG----- 404
Query: 322 EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW-----QMAENIYND 376
+ L GH A + +W+ + ++ S S D+ ++VW ++A ++
Sbjct: 405 --------KYLASLRGHVAAVYQIAWSADSR-LLVSGSSDSTLKVWDVKAQKLAMDLPGH 455
Query: 377 EDPEGSVD--PEGQ 388
D +VD P+GQ
Sbjct: 456 ADEVYAVDWSPDGQ 469
Score = 50.4 bits (119), Expect = 3e-06
Identities = 39/149 (26%), Positives = 71/149 (47%), Gaps = 20/149 (13%)
Query: 223 RSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHK 282
R ++ + S++ H+ V ++F+P ++ LA+GS D TV WDL + + + + H+
Sbjct: 99 RVRAVTRCTSSLEGHSEAVISVAFSPTGKY-LASGSGDTTVRFWDL-STETPHFTCKGHR 156
Query: 283 DEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKI 342
+ + WSP LAS + ++ +WD S G++ A GH+ I
Sbjct: 157 HWVLSISWSPDGRK-LASGCKNGQILLWDPS-TGKQVGRTLA------------GHSKWI 202
Query: 343 SDFSWNP----NEPWVICSVSEDNIMQVW 367
+ SW P E + S S+D +++W
Sbjct: 203 TGLSWEPLHANPECRYVASSSKDGSVRIW 231
Score = 31.6 bits (70), Expect = 1.3
Identities = 22/87 (25%), Positives = 38/87 (43%), Gaps = 15/87 (17%)
Query: 264 ALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPED 323
A++ +R + S E H + + V +SP + + + SG D + WDLS ++P
Sbjct: 96 AIFRVRAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSG-DTTVRFWDLS----TETPH- 149
Query: 324 AEDGPPELLFIHGGHTAKISDFSWNPN 350
F GH + SW+P+
Sbjct: 150 ---------FTCKGHRHWVLSISWSPD 167
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 76.3 bits (186), Expect = 5e-14
Identities = 49/182 (26%), Positives = 88/182 (48%), Gaps = 23/182 (12%)
Query: 141 HQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSW 200
H+ + L WN ++LSA D T +WD +AK F H+A DV W
Sbjct: 277 HKGPIFALKWNRK-GNYILSAGVDKTTIIWD-------AHTGEAKQQFPFHSAPALDVDW 328
Query: 201 HLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSAD 260
+ + F S + D + + +P + HT EVN + ++P S +LA+ S D
Sbjct: 329 Q--NNTTFASCSTDMCIHVCRL---GCDRPVKTFQGHTNEVNAIKWDP-SGMLLASCSDD 382
Query: 261 KTVALWDLRNLKLKLHSFESHKDEIFQVQWSP--------HNETILASSGTDRRLNVWDL 312
T+ +W ++ ++ +H ++H EI+ ++WSP ++ +LAS+ D + +WD+
Sbjct: 383 MTLKIWSMKQ-EVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDI 441
Query: 313 SK 314
+
Sbjct: 442 ER 443
Score = 68.6 bits (166), Expect = 9e-12
Identities = 62/243 (25%), Positives = 107/243 (44%), Gaps = 32/243 (13%)
Query: 138 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEG--KVVDAKTIFTGHTAV- 194
LRGH+ E + +WNP +S L S S D T +W+++ G ++V I G V
Sbjct: 177 LRGHESEVFICAWNP-VSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 235
Query: 195 ----VEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYS 250
V + W+ + +L + + D IW N S ++ H + L +N
Sbjct: 236 SNKDVTSLDWN-TNGTLLATGSYDGFARIWTEDGNLAS----TLGQHKGPIFALKWNRKG 290
Query: 251 EFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVW 310
+IL+ G DKT +WD + K F H V W N T AS TD ++V
Sbjct: 291 NYILSAG-VDKTTIIWDAHTGEAK-QQFPFHSAPALDVDW--QNNTTFASCSTDMCIHV- 345
Query: 311 DLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMA 370
++G ++ + + GHT +++ W+P+ ++ S S+D +++W M
Sbjct: 346 --CRLGCDRPVKTFQ-----------GHTNEVNAIKWDPS-GMLLASCSDDMTLKIWSMK 391
Query: 371 ENI 373
+ +
Sbjct: 392 QEV 394
Score = 61.6 bits (148), Expect = 1e-09
Identities = 39/132 (29%), Positives = 62/132 (46%), Gaps = 14/132 (10%)
Query: 188 FTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSF- 246
F GHT V + W L S +DD L IW + H + AH E+ + +
Sbjct: 357 FQGHTNEVNAIKWDP-SGMLLASCSDDMTLKIWSMKQEVCI---HDLQAHNKEIYTIKWS 412
Query: 247 -------NPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILA 299
NP S +LA+ S D TV LWD+ + H+ H++ ++ V +SP + LA
Sbjct: 413 PTGPATSNPNSNIMLASASFDSTVRLWDIER-GVCTHTLTKHQEPVYSVAFSPDGK-YLA 470
Query: 300 SSGTDRRLNVWD 311
S D+ +++W+
Sbjct: 471 SGSFDKCVHIWN 482
Score = 56.2 bits (134), Expect = 5e-08
Identities = 50/183 (27%), Positives = 86/183 (46%), Gaps = 11/183 (6%)
Query: 134 PDLRLRGHQKEGYGLSWNPNLSGHLL-SASDDHTICLWDISA-VPKEGKVVDAKTIFTGH 191
P +GH E + W+P SG LL S SDD T+ +W + V K I+T
Sbjct: 353 PVKTFQGHTNEVNAIKWDP--SGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIK 410
Query: 192 TAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSE 251
+ + + + S + D + +WD + H++ H V ++F+P +
Sbjct: 411 WSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCT---HTLTKHQEPVYSVAFSPDGK 467
Query: 252 FILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 311
+ LA+GS DK V +W+ ++ L +HS+ IF+V W+ + + +S +D + V D
Sbjct: 468 Y-LASGSFDKCVHIWNTQSGNL-VHSYRG-TGGIFEVCWNARGDKV-GASASDGSVCVLD 523
Query: 312 LSK 314
L K
Sbjct: 524 LRK 526
Score = 37.7 bits (86), Expect = 0.018
Identities = 51/171 (29%), Positives = 75/171 (43%), Gaps = 39/171 (22%)
Query: 125 KPDPSG----ECNPDLRLR--------------GHQKEGYGLSW--------NPNLSGHL 158
K DPSG C+ D+ L+ H KE Y + W NPN + L
Sbjct: 368 KWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIML 427
Query: 159 LSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLM 218
SAS D T+ LWDI + V T+ T H V V++ + L S + D+ +
Sbjct: 428 ASASFDSTVRLWDIE------RGVCTHTL-TKHQEPVYSVAFSPDGKYL-ASGSFDKCVH 479
Query: 219 IWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 269
IW+T+S N HS T + + +N + + A+ S D +V + DLR
Sbjct: 480 IWNTQSGNL---VHSYRG-TGGIFEVCWNARGDKVGASAS-DGSVCVLDLR 525
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 76.3 bits (186), Expect = 5e-14
Identities = 49/182 (26%), Positives = 88/182 (48%), Gaps = 23/182 (12%)
Query: 141 HQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSW 200
H+ + L WN ++LSA D T +WD +AK F H+A DV W
Sbjct: 277 HKGPIFALKWNRK-GNYILSAGVDKTTIIWD-------AHTGEAKQQFPFHSAPALDVDW 328
Query: 201 HLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSAD 260
+ + F S + D + + +P + HT EVN + ++P S +LA+ S D
Sbjct: 329 Q--NNTTFASCSTDMCIHVCRL---GCDRPVKTFQGHTNEVNAIKWDP-SGMLLASCSDD 382
Query: 261 KTVALWDLRNLKLKLHSFESHKDEIFQVQWSP--------HNETILASSGTDRRLNVWDL 312
T+ +W ++ ++ +H ++H EI+ ++WSP ++ +LAS+ D + +WD+
Sbjct: 383 MTLKIWSMKQ-EVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDI 441
Query: 313 SK 314
+
Sbjct: 442 ER 443
Score = 68.6 bits (166), Expect = 9e-12
Identities = 62/243 (25%), Positives = 107/243 (44%), Gaps = 32/243 (13%)
Query: 138 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEG--KVVDAKTIFTGHTAV- 194
LRGH+ E + +WNP +S L S S D T +W+++ G ++V I G V
Sbjct: 177 LRGHESEVFICAWNP-VSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 235
Query: 195 ----VEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYS 250
V + W+ + +L + + D IW N S ++ H + L +N
Sbjct: 236 SNKDVTSLDWN-TNGTLLATGSYDGFARIWTEDGNLAS----TLGQHKGPIFALKWNRKG 290
Query: 251 EFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVW 310
+IL+ G DKT +WD + K F H V W N T AS TD ++V
Sbjct: 291 NYILSAG-VDKTTIIWDAHTGEAK-QQFPFHSAPALDVDW--QNNTTFASCSTDMCIHV- 345
Query: 311 DLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMA 370
++G ++ + + GHT +++ W+P+ ++ S S+D +++W M
Sbjct: 346 --CRLGCDRPVKTFQ-----------GHTNEVNAIKWDPS-GMLLASCSDDMTLKIWSMK 391
Query: 371 ENI 373
+ +
Sbjct: 392 QEV 394
Score = 61.6 bits (148), Expect = 1e-09
Identities = 39/132 (29%), Positives = 62/132 (46%), Gaps = 14/132 (10%)
Query: 188 FTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSF- 246
F GHT V + W L S +DD L IW + H + AH E+ + +
Sbjct: 357 FQGHTNEVNAIKWDP-SGMLLASCSDDMTLKIWSMKQEVCI---HDLQAHNKEIYTIKWS 412
Query: 247 -------NPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILA 299
NP S +LA+ S D TV LWD+ + H+ H++ ++ V +SP + LA
Sbjct: 413 PTGPATSNPNSNIMLASASFDSTVRLWDIER-GVCTHTLTKHQEPVYSVAFSPDGK-YLA 470
Query: 300 SSGTDRRLNVWD 311
S D+ +++W+
Sbjct: 471 SGSFDKCVHIWN 482
Score = 56.2 bits (134), Expect = 5e-08
Identities = 50/183 (27%), Positives = 86/183 (46%), Gaps = 11/183 (6%)
Query: 134 PDLRLRGHQKEGYGLSWNPNLSGHLL-SASDDHTICLWDISA-VPKEGKVVDAKTIFTGH 191
P +GH E + W+P SG LL S SDD T+ +W + V K I+T
Sbjct: 353 PVKTFQGHTNEVNAIKWDP--SGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIK 410
Query: 192 TAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSE 251
+ + + + S + D + +WD + H++ H V ++F+P +
Sbjct: 411 WSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCT---HTLTKHQEPVYSVAFSPDGK 467
Query: 252 FILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 311
+ LA+GS DK V +W+ ++ L +HS+ IF+V W+ + + +S +D + V D
Sbjct: 468 Y-LASGSFDKCVHIWNTQSGNL-VHSYRG-TGGIFEVCWNARGDKV-GASASDGSVCVLD 523
Query: 312 LSK 314
L K
Sbjct: 524 LRK 526
Score = 37.7 bits (86), Expect = 0.018
Identities = 51/171 (29%), Positives = 75/171 (43%), Gaps = 39/171 (22%)
Query: 125 KPDPSG----ECNPDLRLR--------------GHQKEGYGLSW--------NPNLSGHL 158
K DPSG C+ D+ L+ H KE Y + W NPN + L
Sbjct: 368 KWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIML 427
Query: 159 LSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLM 218
SAS D T+ LWDI + V T+ T H V V++ + L S + D+ +
Sbjct: 428 ASASFDSTVRLWDIE------RGVCTHTL-TKHQEPVYSVAFSPDGKYL-ASGSFDKCVH 479
Query: 219 IWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 269
IW+T+S N HS T + + +N + + A+ S D +V + DLR
Sbjct: 480 IWNTQSGNL---VHSYRG-TGGIFEVCWNARGDKVGASAS-DGSVCVLDLR 525
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 76.3 bits (186), Expect = 5e-14
Identities = 49/182 (26%), Positives = 88/182 (48%), Gaps = 23/182 (12%)
Query: 141 HQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSW 200
H+ + L WN ++LSA D T +WD +AK F H+A DV W
Sbjct: 328 HKGPIFALKWNRK-GNYILSAGVDKTTIIWD-------AHTGEAKQQFPFHSAPALDVDW 379
Query: 201 HLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSAD 260
+ + F S + D + + +P + HT EVN + ++P S +LA+ S D
Sbjct: 380 Q--NNTTFASCSTDMCIHVCRL---GCDRPVKTFQGHTNEVNAIKWDP-SGMLLASCSDD 433
Query: 261 KTVALWDLRNLKLKLHSFESHKDEIFQVQWSP--------HNETILASSGTDRRLNVWDL 312
T+ +W ++ ++ +H ++H EI+ ++WSP ++ +LAS+ D + +WD+
Sbjct: 434 MTLKIWSMKQ-EVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDI 492
Query: 313 SK 314
+
Sbjct: 493 ER 494
Score = 68.6 bits (166), Expect = 9e-12
Identities = 62/243 (25%), Positives = 107/243 (44%), Gaps = 32/243 (13%)
Query: 138 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEG--KVVDAKTIFTGHTAV- 194
LRGH+ E + +WNP +S L S S D T +W+++ G ++V I G V
Sbjct: 228 LRGHESEVFICAWNP-VSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 286
Query: 195 ----VEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYS 250
V + W+ + +L + + D IW N S ++ H + L +N
Sbjct: 287 SNKDVTSLDWN-TNGTLLATGSYDGFARIWTEDGNLAS----TLGQHKGPIFALKWNRKG 341
Query: 251 EFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVW 310
+IL+ G DKT +WD + K F H V W N T AS TD ++V
Sbjct: 342 NYILSAG-VDKTTIIWDAHTGEAK-QQFPFHSAPALDVDW--QNNTTFASCSTDMCIHV- 396
Query: 311 DLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMA 370
++G ++ + + GHT +++ W+P+ ++ S S+D +++W M
Sbjct: 397 --CRLGCDRPVKTFQ-----------GHTNEVNAIKWDPS-GMLLASCSDDMTLKIWSMK 442
Query: 371 ENI 373
+ +
Sbjct: 443 QEV 445
Score = 61.6 bits (148), Expect = 1e-09
Identities = 39/132 (29%), Positives = 62/132 (46%), Gaps = 14/132 (10%)
Query: 188 FTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSF- 246
F GHT V + W L S +DD L IW + H + AH E+ + +
Sbjct: 408 FQGHTNEVNAIKWDP-SGMLLASCSDDMTLKIWSMKQEVCI---HDLQAHNKEIYTIKWS 463
Query: 247 -------NPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILA 299
NP S +LA+ S D TV LWD+ + H+ H++ ++ V +SP + LA
Sbjct: 464 PTGPATSNPNSNIMLASASFDSTVRLWDIER-GVCTHTLTKHQEPVYSVAFSPDGK-YLA 521
Query: 300 SSGTDRRLNVWD 311
S D+ +++W+
Sbjct: 522 SGSFDKCVHIWN 533
Score = 56.2 bits (134), Expect = 5e-08
Identities = 50/183 (27%), Positives = 86/183 (46%), Gaps = 11/183 (6%)
Query: 134 PDLRLRGHQKEGYGLSWNPNLSGHLL-SASDDHTICLWDISA-VPKEGKVVDAKTIFTGH 191
P +GH E + W+P SG LL S SDD T+ +W + V K I+T
Sbjct: 404 PVKTFQGHTNEVNAIKWDP--SGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIK 461
Query: 192 TAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSE 251
+ + + + S + D + +WD + H++ H V ++F+P +
Sbjct: 462 WSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCT---HTLTKHQEPVYSVAFSPDGK 518
Query: 252 FILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 311
+ LA+GS DK V +W+ ++ L +HS+ IF+V W+ + + +S +D + V D
Sbjct: 519 Y-LASGSFDKCVHIWNTQSGNL-VHSYRG-TGGIFEVCWNARGDKV-GASASDGSVCVLD 574
Query: 312 LSK 314
L K
Sbjct: 575 LRK 577
Score = 37.7 bits (86), Expect = 0.018
Identities = 51/171 (29%), Positives = 75/171 (43%), Gaps = 39/171 (22%)
Query: 125 KPDPSG----ECNPDLRLR--------------GHQKEGYGLSW--------NPNLSGHL 158
K DPSG C+ D+ L+ H KE Y + W NPN + L
Sbjct: 419 KWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIML 478
Query: 159 LSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLM 218
SAS D T+ LWDI + V T+ T H V V++ + L S + D+ +
Sbjct: 479 ASASFDSTVRLWDIE------RGVCTHTL-TKHQEPVYSVAFSPDGKYL-ASGSFDKCVH 530
Query: 219 IWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 269
IW+T+S N HS T + + +N + + A+ S D +V + DLR
Sbjct: 531 IWNTQSGNL---VHSYRG-TGGIFEVCWNARGDKVGASAS-DGSVCVLDLR 576
>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 76.3 bits (186), Expect = 5e-14
Identities = 49/182 (26%), Positives = 88/182 (48%), Gaps = 23/182 (12%)
Query: 141 HQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSW 200
H+ + L WN ++LSA D T +WD +AK F H+A DV W
Sbjct: 328 HKGPIFALKWNRK-GNYILSAGVDKTTIIWD-------AHTGEAKQQFPFHSAPALDVDW 379
Query: 201 HLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSAD 260
+ + F S + D + + +P + HT EVN + ++P S +LA+ S D
Sbjct: 380 Q--NNTTFASCSTDMCIHVCRL---GCDRPVKTFQGHTNEVNAIKWDP-SGMLLASCSDD 433
Query: 261 KTVALWDLRNLKLKLHSFESHKDEIFQVQWSP--------HNETILASSGTDRRLNVWDL 312
T+ +W ++ ++ +H ++H EI+ ++WSP ++ +LAS+ D + +WD+
Sbjct: 434 MTLKIWSMKQ-EVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDI 492
Query: 313 SK 314
+
Sbjct: 493 ER 494
Score = 68.6 bits (166), Expect = 9e-12
Identities = 62/243 (25%), Positives = 107/243 (44%), Gaps = 32/243 (13%)
Query: 138 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEG--KVVDAKTIFTGHTAV- 194
LRGH+ E + +WNP +S L S S D T +W+++ G ++V I G V
Sbjct: 228 LRGHESEVFICAWNP-VSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 286
Query: 195 ----VEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYS 250
V + W+ + +L + + D IW N S ++ H + L +N
Sbjct: 287 SNKDVTSLDWN-TNGTLLATGSYDGFARIWTEDGNLAS----TLGQHKGPIFALKWNRKG 341
Query: 251 EFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVW 310
+IL+ G DKT +WD + K F H V W N T AS TD ++V
Sbjct: 342 NYILSAG-VDKTTIIWDAHTGEAK-QQFPFHSAPALDVDW--QNNTTFASCSTDMCIHV- 396
Query: 311 DLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMA 370
++G ++ + + GHT +++ W+P+ ++ S S+D +++W M
Sbjct: 397 --CRLGCDRPVKTFQ-----------GHTNEVNAIKWDPS-GMLLASCSDDMTLKIWSMK 442
Query: 371 ENI 373
+ +
Sbjct: 443 QEV 445
Score = 61.6 bits (148), Expect = 1e-09
Identities = 39/132 (29%), Positives = 62/132 (46%), Gaps = 14/132 (10%)
Query: 188 FTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSF- 246
F GHT V + W L S +DD L IW + H + AH E+ + +
Sbjct: 408 FQGHTNEVNAIKWDP-SGMLLASCSDDMTLKIWSMKQEVCI---HDLQAHNKEIYTIKWS 463
Query: 247 -------NPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILA 299
NP S +LA+ S D TV LWD+ + H+ H++ ++ V +SP + LA
Sbjct: 464 PTGPATSNPNSNIMLASASFDSTVRLWDIER-GVCTHTLTKHQEPVYSVAFSPDGK-YLA 521
Query: 300 SSGTDRRLNVWD 311
S D+ +++W+
Sbjct: 522 SGSFDKCVHIWN 533
Score = 56.2 bits (134), Expect = 5e-08
Identities = 50/183 (27%), Positives = 86/183 (46%), Gaps = 11/183 (6%)
Query: 134 PDLRLRGHQKEGYGLSWNPNLSGHLL-SASDDHTICLWDISA-VPKEGKVVDAKTIFTGH 191
P +GH E + W+P SG LL S SDD T+ +W + V K I+T
Sbjct: 404 PVKTFQGHTNEVNAIKWDP--SGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIK 461
Query: 192 TAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSE 251
+ + + + S + D + +WD + H++ H V ++F+P +
Sbjct: 462 WSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCT---HTLTKHQEPVYSVAFSPDGK 518
Query: 252 FILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 311
+ LA+GS DK V +W+ ++ L +HS+ IF+V W+ + + +S +D + V D
Sbjct: 519 Y-LASGSFDKCVHIWNTQSGNL-VHSYRG-TGGIFEVCWNARGDKV-GASASDGSVCVLD 574
Query: 312 LSK 314
L K
Sbjct: 575 LRK 577
Score = 37.7 bits (86), Expect = 0.018
Identities = 51/171 (29%), Positives = 75/171 (43%), Gaps = 39/171 (22%)
Query: 125 KPDPSG----ECNPDLRLR--------------GHQKEGYGLSW--------NPNLSGHL 158
K DPSG C+ D+ L+ H KE Y + W NPN + L
Sbjct: 419 KWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIML 478
Query: 159 LSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLM 218
SAS D T+ LWDI + V T+ T H V V++ + L S + D+ +
Sbjct: 479 ASASFDSTVRLWDIE------RGVCTHTL-TKHQEPVYSVAFSPDGKYL-ASGSFDKCVH 530
Query: 219 IWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 269
IW+T+S N HS T + + +N + + A+ S D +V + DLR
Sbjct: 531 IWNTQSGNL---VHSYRG-TGGIFEVCWNARGDKVGASAS-DGSVCVLDLR 576
>gi|109627650 coronin 6 [Homo sapiens]
Length = 472
Score = 75.1 bits (183), Expect = 1e-13
Identities = 51/188 (27%), Positives = 90/188 (47%), Gaps = 15/188 (7%)
Query: 177 KEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWD----TRSNNTSKPSH 232
K G+V + TGHTA V D+ W ++++ S +DD +M+W T N ++P
Sbjct: 66 KTGRVDKNYPLVTGHTAPVLDIDWCPHNDNVIASASDDTTIMVWQIPDYTPMRNITEPII 125
Query: 233 SVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSP 292
+++ H+ V LS++P + +L + D + +W++ ++ L + H D I V W+
Sbjct: 126 TLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTGEVLLSLDDMHPDVIHSVCWN- 184
Query: 293 HNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDG--PPELLFIHGGH--TAKISDFS-- 346
N ++LA++ D+ L + D K A +G P +F GH T + S
Sbjct: 185 SNGSLLATTCKDKTLRIIDPRKGQVVAERFAAHEGMRPMRAVFTRQGHIFTTGFTRMSQR 244
Query: 347 ----WNPN 350
W+PN
Sbjct: 245 ELGLWDPN 252
Score = 55.8 bits (133), Expect = 6e-08
Identities = 47/198 (23%), Positives = 81/198 (40%), Gaps = 10/198 (5%)
Query: 140 GHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 199
GH + W P+ + SASDD TI +W I + + GH+ V +S
Sbjct: 79 GHTAPVLDIDWCPHNDNVIASASDDTTIMVWQIPDYTPMRNITEPIITLEGHSKRVGILS 138
Query: 200 WHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSA 259
WH ++ S D ++IW+ + D H ++ + +N +LAT
Sbjct: 139 WHPTARNVLLSAGGDNVIIIWNVGTGEVLLSLD--DMHPDVIHSVCWNSNGS-LLATTCK 195
Query: 260 DKTVALWDLRNLKLKLHSFESHKD-----EIFQVQWSPHNETILASSGTDRRLNVWDLSK 314
DKT+ + D R ++ F +H+ +F Q H T + + R L +WD +
Sbjct: 196 DKTLRIIDPRKGQVVAERFAAHEGMRPMRAVFTRQ--GHIFTTGFTRMSQRELGLWDPNN 253
Query: 315 IGEEQSPEDAEDGPPELL 332
E + ++ + LL
Sbjct: 254 FEEPVALQEMDTSNGVLL 271
Score = 49.7 bits (117), Expect = 5e-06
Identities = 48/191 (25%), Positives = 79/191 (41%), Gaps = 21/191 (10%)
Query: 88 HEGEVNRARYMPQNPCIIATKTPSSDVLVF---DYTKHPSKPDPSGECNPDLRLRGHQKE 144
H V + P N +IA+ + + ++V+ DYT + +P + L GH K
Sbjct: 80 HTAPVLDIDWCPHNDNVIASASDDTTIMVWQIPDYTPMRNITEPI------ITLEGHSKR 133
Query: 145 GYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLH 204
LSW+P LLSA D+ I +W++ G+V+ ++ H V+ V W+ +
Sbjct: 134 VGILSWHPTARNVLLSAGGDNVIIIWNVGT----GEVL--LSLDDMHPDVIHSVCWN-SN 186
Query: 205 ESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG---SADK 261
SL + D+ L I D R + AH + I TG + +
Sbjct: 187 GSLLATTCKDKTLRIIDPRKGQV--VAERFAAHEGMRPMRAVFTRQGHIFTTGFTRMSQR 244
Query: 262 TVALWDLRNLK 272
+ LWD N +
Sbjct: 245 ELGLWDPNNFE 255
Score = 48.5 bits (114), Expect = 1e-05
Identities = 21/89 (23%), Positives = 41/89 (46%), Gaps = 7/89 (7%)
Query: 281 HKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTA 340
H + + W PHN+ ++AS+ D + VW + ++ E + GH+
Sbjct: 80 HTAPVLDIDWCPHNDNVIASASDDTTIMVWQIPDYTPMRNIT-------EPIITLEGHSK 132
Query: 341 KISDFSWNPNEPWVICSVSEDNIMQVWQM 369
++ SW+P V+ S DN++ +W +
Sbjct: 133 RVGILSWHPTARNVLLSAGGDNVIIIWNV 161
Score = 37.7 bits (86), Expect = 0.018
Identities = 15/35 (42%), Positives = 21/35 (60%)
Query: 337 GHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 371
GHTA + D W P+ VI S S+D + VWQ+ +
Sbjct: 79 GHTAPVLDIDWCPHNDNVIASASDDTTIMVWQIPD 113
>gi|21359963 ring finger and WD repeat domain 2 isoform a [Homo
sapiens]
Length = 731
Score = 74.7 bits (182), Expect = 1e-13
Identities = 49/167 (29%), Positives = 81/167 (48%), Gaps = 13/167 (7%)
Query: 148 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL 207
+SW+ L S+ + T+ LWD G ++ H V ++L+ L
Sbjct: 476 ISWSSYHKNLLASSDYEGTVILWD-------GFTGQRSKVYQEHEKRCWSVDFNLMDPKL 528
Query: 208 FGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 267
S +DD K+ +W T +N+ S++A A V C+ F+P S + LA G AD V +D
Sbjct: 529 LASGSDDAKVKLWSTNLDNSVA---SIEAK-ANVCCVKFSPSSRYHLAFGCADHCVHYYD 584
Query: 268 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSK 314
LRN K + F+ H+ + ++ E + AS TD +L +W++ K
Sbjct: 585 LRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSAS--TDSQLKLWNVGK 629
Score = 38.5 bits (88), Expect = 0.010
Identities = 18/73 (24%), Positives = 42/73 (57%), Gaps = 3/73 (4%)
Query: 239 AEVNCLSFNPYSEFILATGSADKTVALWD-LRNLKLKLHSFESHKDEIFQVQWSPHNETI 297
++++C+S++ Y + +LA+ + TV LWD + K+ ++ H+ + V ++ + +
Sbjct: 471 SKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKV--YQEHEKRCWSVDFNLMDPKL 528
Query: 298 LASSGTDRRLNVW 310
LAS D ++ +W
Sbjct: 529 LASGSDDAKVKLW 541
>gi|50233824 ring finger and WD repeat domain 2 isoform d24 [Homo
sapiens]
Length = 707
Score = 74.7 bits (182), Expect = 1e-13
Identities = 49/167 (29%), Positives = 81/167 (48%), Gaps = 13/167 (7%)
Query: 148 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL 207
+SW+ L S+ + T+ LWD G ++ H V ++L+ L
Sbjct: 452 ISWSSYHKNLLASSDYEGTVILWD-------GFTGQRSKVYQEHEKRCWSVDFNLMDPKL 504
Query: 208 FGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 267
S +DD K+ +W T +N+ S++A A V C+ F+P S + LA G AD V +D
Sbjct: 505 LASGSDDAKVKLWSTNLDNSVA---SIEAK-ANVCCVKFSPSSRYHLAFGCADHCVHYYD 560
Query: 268 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSK 314
LRN K + F+ H+ + ++ E + AS TD +L +W++ K
Sbjct: 561 LRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSAS--TDSQLKLWNVGK 605
Score = 38.5 bits (88), Expect = 0.010
Identities = 18/73 (24%), Positives = 42/73 (57%), Gaps = 3/73 (4%)
Query: 239 AEVNCLSFNPYSEFILATGSADKTVALWD-LRNLKLKLHSFESHKDEIFQVQWSPHNETI 297
++++C+S++ Y + +LA+ + TV LWD + K+ ++ H+ + V ++ + +
Sbjct: 447 SKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKV--YQEHEKRCWSVDFNLMDPKL 504
Query: 298 LASSGTDRRLNVW 310
LAS D ++ +W
Sbjct: 505 LASGSDDAKVKLW 517
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 74.3 bits (181), Expect = 2e-13
Identities = 65/219 (29%), Positives = 106/219 (48%), Gaps = 35/219 (15%)
Query: 153 NLSGH-LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSV 211
N SG ++ S D T LWD ++ G+ ++ GH VV ++++ + +
Sbjct: 101 NKSGSCFITGSYDRTCKLWDTAS----GEELNT---LEGHRNVVYAIAFNNPYGDKIATG 153
Query: 212 ADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL 271
+ D+ +W S T K H+ HTAE+ CLSFNP S ++ATGS D T LWD++N
Sbjct: 154 SFDKTCKLW---SVETGKCYHTFRGHTAEIVCLSFNPQST-LVATGSMDTTAKLWDIQNG 209
Query: 272 KLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPEL 331
+ ++++ H EI + ++ + I+ S D + VW DA+ G
Sbjct: 210 E-EVYTLRGHSAEIISLSFNTSGDRIITGS-FDHTVVVW------------DADTGRKVN 255
Query: 332 LFIHGGHTAKISDFSWNPNEPW---VICSVSEDNIMQVW 367
+ I GH A+IS S+N W +I + S D ++W
Sbjct: 256 ILI--GHCAEISSASFN----WDCSLILTGSMDKTCKLW 288
Score = 62.4 bits (150), Expect = 7e-10
Identities = 64/233 (27%), Positives = 102/233 (43%), Gaps = 38/233 (16%)
Query: 139 RGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFT--GHTAVVE 196
RGH E LS+NP S + + S D T LWDI + + ++T GH+A +
Sbjct: 174 RGHTAEIVCLSFNPQ-STLVATGSMDTTAKLWDIQ---------NGEEVYTLRGHSAEII 223
Query: 197 DVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILAT 256
+S++ + + + D +++WD +T + + + H AE++ SFN IL T
Sbjct: 224 SLSFNTSGDRIITG-SFDHTVVVWDA---DTGRKVNILIGHCAEISSASFNWDCSLIL-T 278
Query: 257 GSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASS--GTDRRLNVWDLSK 314
GS DKT LWD N K + + H DEI + + I +S GT R +
Sbjct: 279 GSMDKTCKLWDATNGKC-VATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKC 337
Query: 315 IGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 367
I + + GH +IS S+NP ++ S D ++W
Sbjct: 338 IAKLE-----------------GHEGEISKISFNPQGNHLLTG-SSDKTARIW 372
Score = 60.5 bits (145), Expect = 3e-09
Identities = 53/212 (25%), Positives = 86/212 (40%), Gaps = 51/212 (24%)
Query: 138 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 197
LRGH E LS+N + +++ S DHT+ +WD G+ V+ I GH A +
Sbjct: 215 LRGHSAEIISLSFNTS-GDRIITGSFDHTVVVWDADT----GRKVN---ILIGHCAEISS 266
Query: 198 VSWHLLHESLFGSVADDQKLMIWDTRSNN------------------------------- 226
S++ SL + + D+ +WD +
Sbjct: 267 ASFNW-DCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADG 325
Query: 227 --------TSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSF 278
T K ++ H E++ +SFNP +L TGS+DKT +WD + + L
Sbjct: 326 TARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLL-TGSSDKTARIWDAQTGQC-LQVL 383
Query: 279 ESHKDEIFQVQWSPHNETILASSGTDRRLNVW 310
E H DEIF ++ + I+ + D +W
Sbjct: 384 EGHTDEIFSCAFN-YKGNIVITGSKDNTCRIW 414
Score = 57.4 bits (137), Expect = 2e-08
Identities = 48/174 (27%), Positives = 82/174 (47%), Gaps = 14/174 (8%)
Query: 138 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 197
L GH+ Y +++N + + S D T LW + + GK F GHTA +
Sbjct: 130 LEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSV----ETGKCYHT---FRGHTAEIVC 182
Query: 198 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 257
+S++ +L + + D +WD ++ + +++ H+AE+ LSFN + I+ TG
Sbjct: 183 LSFN-PQSTLVATGSMDTTAKLWDIQN---GEEVYTLRGHSAEIISLSFNTSGDRII-TG 237
Query: 258 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 311
S D TV +WD + K++ H EI ++ IL S D+ +WD
Sbjct: 238 SFDHTVVVWD-ADTGRKVNILIGHCAEISSASFNWDCSLILTGS-MDKTCKLWD 289
Score = 32.0 bits (71), Expect = 0.98
Identities = 15/35 (42%), Positives = 21/35 (60%), Gaps = 1/35 (2%)
Query: 137 RLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWD 171
+L GH+ E +S+NP HLL+ S D T +WD
Sbjct: 340 KLEGHEGEISKISFNPQ-GNHLLTGSSDKTARIWD 373
>gi|58331266 WD repeat domain 59 [Homo sapiens]
Length = 974
Score = 72.0 bits (175), Expect = 9e-13
Identities = 54/187 (28%), Positives = 86/187 (45%), Gaps = 17/187 (9%)
Query: 133 NPDLRLRGHQKEGY-------GLSWNPNLS-GHLLSASDDHTICLWDISAVPKEGKVVDA 184
N D GH+K + WNP+ S H +AS + + L+ K+G +
Sbjct: 43 NLDAPFEGHRKISRQSKWDIGAVQWNPHDSFAHYFAASSNQRVDLYKW----KDGSG-EV 97
Query: 185 KTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCL 244
T GHT V+ D+ W + L + + D + IWD + +T KP+ ++ A A + +
Sbjct: 98 GTTLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIK--DTRKPTVALSA-VAGASQV 154
Query: 245 SFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTD 304
+N + LAT S D V +WD R + +H +I + W P +E ILA+S D
Sbjct: 155 KWNKKNANCLAT-SHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQD 213
Query: 305 RRLNVWD 311
+ WD
Sbjct: 214 NSVKFWD 220
Score = 60.1 bits (144), Expect = 3e-09
Identities = 62/260 (23%), Positives = 95/260 (36%), Gaps = 69/260 (26%)
Query: 127 DPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKT 186
D SGE L+ GH + L W L+++S D I +WDI K T
Sbjct: 92 DGSGEVGTTLQ--GHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKDTRKP-------T 142
Query: 187 IFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVD---AHTAEVNC 243
+ A V W+ + + + + D + IWD R KPS +V+ AH ++++
Sbjct: 143 VALSAVAGASQVKWNKKNANCLAT-SHDGDVRIWDKR-----KPSTAVEYLAAHLSKIHG 196
Query: 244 LSFNPYSEFILATGSADKTVALWDLR---------------------------------- 269
L ++P SE ILAT S D +V WD R
Sbjct: 197 LDWHPDSEHILATSSQDNSVKFWDYRQPRKYLNILPCQVPVWKARYTPFSNGLVTVMVPQ 256
Query: 270 -------------NLKLKLHSFESHKDEIFQVQWSPHNETI----LASSGTDRRLNVWDL 312
+L +H+F H D + + QW E L + D+ L +W +
Sbjct: 257 LRRENSLLLWNVFDLNTPVHTFVGHDDVVLEFQWRKQKEGSKDYQLVTWSRDQTLRMWRV 316
Query: 313 SKIGEEQSPEDAEDGPPELL 332
+ D DG E +
Sbjct: 317 DSQMQRLCANDILDGVDEFI 336
Score = 37.0 bits (84), Expect = 0.031
Identities = 29/104 (27%), Positives = 42/104 (40%), Gaps = 24/104 (23%)
Query: 278 FESHKD-------EIFQVQWSPHNET---ILASSGTDRRLNVWDLSKIGEEQSPEDAEDG 327
FE H+ +I VQW+PH+ ASS L W +DG
Sbjct: 48 FEGHRKISRQSKWDIGAVQWNPHDSFAHYFAASSNQRVDLYKW--------------KDG 93
Query: 328 PPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 371
E+ GHT ISD W EP ++ + S D + +W + +
Sbjct: 94 SGEVGTTLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKD 137
>gi|4757988 WD repeat domain 39 [Homo sapiens]
Length = 339
Score = 71.6 bits (174), Expect = 1e-12
Identities = 62/283 (21%), Positives = 114/283 (40%), Gaps = 63/283 (22%)
Query: 140 GHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 199
GHQ+ ++W+P +L SAS D T C+W K + T GH V+ V+
Sbjct: 59 GHQRTVRKVAWSP-CGNYLASASFDATTCIWK-----KNQDDFECVTTLEGHENEVKSVA 112
Query: 200 WHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSA 259
W +L + + D+ + +W+ + + +++HT +V + ++P S+ +LA+ S
Sbjct: 113 W-APSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHP-SQELLASASY 170
Query: 260 DKTVALW-DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEE 318
D TV L+ + + + + E H+ ++ + + P + LAS DR + +W G E
Sbjct: 171 DDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQR-LASCSDDRTVRIWRQYLPGNE 229
Query: 319 QS------------------------------------------------PEDAEDGPPE 330
Q ED P +
Sbjct: 230 QGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQ 289
Query: 331 LLF-----IHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQ 368
F +H H+ ++ +WNP EP ++ S S+D + W+
Sbjct: 290 PTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWK 332
Score = 57.4 bits (137), Expect = 2e-08
Identities = 40/143 (27%), Positives = 70/143 (48%), Gaps = 15/143 (10%)
Query: 138 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLW------DISAVPKEGKVVDAKTIFT-- 189
L GH+ + L+++P+ L S SDD T+ +W + V G K I T
Sbjct: 190 LEGHESTVWSLAFDPS-GQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLS 248
Query: 190 -GHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSV-----DAHTAEVNC 243
H+ + D++W L +L + DD + + +++ +P+ S+ AH+ +VNC
Sbjct: 249 GFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNC 308
Query: 244 LSFNPYSEFILATGSADKTVALW 266
+++NP +LA+ S D VA W
Sbjct: 309 VAWNPKEPGLLASCSDDGEVAFW 331
Score = 57.0 bits (136), Expect = 3e-08
Identities = 40/186 (21%), Positives = 77/186 (41%), Gaps = 34/186 (18%)
Query: 206 SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 265
+L S D+++ IW T ++ S + H V ++++P + LA+ S D T +
Sbjct: 29 TLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNY-LASASFDATTCI 87
Query: 266 WDLRNLKLK-LHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDA 324
W + + + E H++E+ V W+P +LA+ D+ + VW++
Sbjct: 88 WKKNQDDFECVTTLEGHENEVKSVAWAPSGN-LLATCSRDKSVWVWEVD----------- 135
Query: 325 EDGPPELLFIHGGHTAKISDFSWNPNEP--------------------WVICSVSEDNIM 364
E+ E + + HT + W+P++ WV C+ E +
Sbjct: 136 EEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHES 195
Query: 365 QVWQMA 370
VW +A
Sbjct: 196 TVWSLA 201
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 71.2 bits (173), Expect = 1e-12
Identities = 75/283 (26%), Positives = 120/283 (42%), Gaps = 45/283 (15%)
Query: 88 HEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYG 147
H GEVN + + P ++ T S D V+ + SG+ RL GH
Sbjct: 20 HGGEVNSSAFSPDGQMLL---TGSEDGCVYGWETR------SGQLL--WRLGGHTGPVKF 68
Query: 148 LSWNPNLSGHLL-SASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHES 206
++P+ GHL SAS D T+ LWD++ + GH VE VS+
Sbjct: 69 CRFSPD--GHLFASASCDCTVRLWDVARAK-------CLRVLKGHQRSVETVSFSPDSRQ 119
Query: 207 LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 266
L S D+++M+WD +S + + H + F+P LATGS D TV +W
Sbjct: 120 L-ASGGWDKRVMLWDVQSGQMLR---LLVGHRDSIQSSDFSPTVN-CLATGSWDSTVHIW 174
Query: 267 DLRNL--KLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDA 324
DLR + + + E H I + +S +LAS D+ +++W
Sbjct: 175 DLRMVTPAVSHQALEGHSANISCLCYSASG--LLASGSWDKTIHIW-------------- 218
Query: 325 EDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 367
+ LL GH + +++P+E W + S +++VW
Sbjct: 219 KPTTSSLLIQLKGHVTWVKSIAFSPDELW-LASAGYSRMVKVW 260
Score = 67.0 bits (162), Expect = 3e-11
Identities = 65/248 (26%), Positives = 118/248 (47%), Gaps = 27/248 (10%)
Query: 65 SEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPS 124
SE G G+ + SG++ + H G V R+ P + A+ + V ++D +
Sbjct: 40 SEDGCVYGWETRSGQLLWRLG-GHTGPVKFCRFSPDGH-LFASASCDCTVRLWDVAR--- 94
Query: 125 KPDPSGECNPDLR-LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVD 183
+C LR L+GHQ+ +S++P+ S L S D + LWD+ + G+++
Sbjct: 95 -----AKC---LRVLKGHQRSVETVSFSPD-SRQLASGGWDKRVMLWDVQS----GQML- 140
Query: 184 AKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNC 243
+ GH ++ + L + + D + IWD R + +++ H+A ++C
Sbjct: 141 --RLLVGHRDSIQSSDFSPTVNCL-ATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISC 197
Query: 244 LSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGT 303
L ++ + +LA+GS DKT+ +W L L + H + + +SP +E LAS+G
Sbjct: 198 LCYS--ASGLLASGSWDKTIHIWKPTTSSL-LIQLKGHVTWVKSIAFSP-DELWLASAGY 253
Query: 304 DRRLNVWD 311
R + VWD
Sbjct: 254 SRMVKVWD 261
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 71.2 bits (173), Expect = 1e-12
Identities = 65/247 (26%), Positives = 108/247 (43%), Gaps = 32/247 (12%)
Query: 133 NPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEG--KVVDAKTIFTG 190
N + LRGH+ E + +WNP +S L S S D T +W++S G ++V I G
Sbjct: 160 NKAVVLRGHESEVFICAWNP-VSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREG 218
Query: 191 HTAV-----VEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLS 245
V V + W+ +L + + D IW N S ++ H + L
Sbjct: 219 GQDVPSNKDVTSLDWN-SEGTLLATGSYDGFARIWTKDGNLAS----TLGQHKGPIFALK 273
Query: 246 FNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDR 305
+N FIL+ G DKT +WD + K F H V W +N AS TD
Sbjct: 274 WNKKGNFILSAG-VDKTTIIWDAHTGEAK-QQFPFHSAPALDVDWQSNN--TFASCSTDM 329
Query: 306 RLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQ 365
++V K+G+++ + + GHT +++ W+P ++ S S+D ++
Sbjct: 330 CIHV---CKLGQDRPIKTFQ-----------GHTNEVNAIKWDPTGN-LLASCSDDMTLK 374
Query: 366 VWQMAEN 372
+W M ++
Sbjct: 375 IWSMKQD 381
Score = 66.2 bits (160), Expect = 5e-11
Identities = 55/214 (25%), Positives = 87/214 (40%), Gaps = 51/214 (23%)
Query: 141 HQKEGYGLSWNPNLSGHLLSASDDHTICLWDISA-------------------------- 174
H+ + L WN +LSA D T +WD
Sbjct: 265 HKGPIFALKWNKK-GNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFA 323
Query: 175 ---------VPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSN 225
V K G+ KT F GHT V + W +L S +DD L IW + +
Sbjct: 324 SCSTDMCIHVCKLGQDRPIKT-FQGHTNEVNAIKWDPTG-NLLASCSDDMTLKIWSMKQD 381
Query: 226 NTSKPSHSVDAHTAEVNCLSF--------NPYSEFILATGSADKTVALWDLRNLKLKLHS 277
N H + AH E+ + + NP + +LA+ S D TV LWD+ + + +H+
Sbjct: 382 NCV---HDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDV-DRGICIHT 437
Query: 278 FESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 311
H++ ++ V +SP LAS D+ +++W+
Sbjct: 438 LTKHQEPVYSVAFSPDGR-YLASGSFDKCVHIWN 470
Score = 37.0 bits (84), Expect = 0.031
Identities = 46/185 (24%), Positives = 70/185 (37%), Gaps = 65/185 (35%)
Query: 138 LRGHQKEGYGLSW--------NPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFT 189
L+ H KE Y + W NPN + L SAS D T+ LWD+
Sbjct: 387 LQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVD---------------- 430
Query: 190 GHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPY 249
+ H L +P +SV +F+P
Sbjct: 431 ------RGICIHTL---------------------TKHQEPVYSV----------AFSPD 453
Query: 250 SEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNV 309
+ LA+GS DK V +W+ + L +HS+ IF+V W+ + + +S +D + V
Sbjct: 454 GRY-LASGSFDKCVHIWNTQTGAL-VHSYRG-TGGIFEVCWNAAGDKV-GASASDGSVCV 509
Query: 310 WDLSK 314
DL K
Sbjct: 510 LDLRK 514
>gi|4507703 tumor suppressing subtransferable candidate 1 [Homo
sapiens]
Length = 387
Score = 71.2 bits (173), Expect = 1e-12
Identities = 71/328 (21%), Positives = 127/328 (38%), Gaps = 45/328 (13%)
Query: 73 FGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIAT---KTPSSDVLV----------FDY 119
F + I + ++ GE+ P + ++ T +T S VL +
Sbjct: 48 FDDENNIINKNVLLHQAGEIWHISASPADRGVLTTCYNRTSDSKVLTCAAVWRMPKELES 107
Query: 120 TKHPSKPDPSGECNPDLRLRGH-QKEGYG----LSWNPNLSGHLLSASDDHTICLWDISA 174
H S PD S L L H +G + W P G + + D+ I LWD+
Sbjct: 108 GSHES-PDDSSSTAQTLELLCHLDNTAHGNMACVVWEPMGDGKKIISLADNHILLWDLQE 166
Query: 175 VPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSV 234
+ + + ++ W H + A+D L WDTRS S+
Sbjct: 167 SSSQAVLASSASLEGKGQLKFTSGRWSPHHNCTQVATANDTTLRGWDTRS--MSQIYCIE 224
Query: 235 DAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHN 294
+AH V L FNP ++ LA+ D V WD RN+ + + E H ++ V+++ +
Sbjct: 225 NAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRNVTEPVKTLEEHSHWVWNVRYNHSH 284
Query: 295 ETILASSGTDRRLNVWDLSKI---------------------GEEQSPEDAEDGPPELLF 333
+ ++ + +D R+ + ++ I EE+S E +D ++
Sbjct: 285 DQLVLTGSSDSRVILSNMVSISSEPFGHLVDDDDISDQEDHRSEEKSKEPLQD---NVIA 341
Query: 334 IHGGHTAKISDFSWNPNEPWVICSVSED 361
+ H + W+ +PW+ S+S D
Sbjct: 342 TYEEHEDSVYAVDWSSADPWLFASLSYD 369
Score = 53.1 bits (126), Expect = 4e-07
Identities = 40/189 (21%), Positives = 84/189 (44%), Gaps = 39/189 (20%)
Query: 150 WNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFG 209
W+P+ + ++ ++D T+ WD ++ + + +A H +V D+ ++ +
Sbjct: 192 WSPHHNCTQVATANDTTLRGWDTRSMSQIYCIENA------HGQLVRDLDFNPNKQYYLA 245
Query: 210 SVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 269
S DD K+ WDTR N ++P +++ H+ V + +N + ++ TGS+D V L ++
Sbjct: 246 SCGDDCKVKFWDTR--NVTEPVKTLEEHSHWVWNVRYNHSHDQLVLTGSSDSRVILSNMV 303
Query: 270 NLKLK-------------------------------LHSFESHKDEIFQVQWSPHNETIL 298
++ + + ++E H+D ++ V WS + +
Sbjct: 304 SISSEPFGHLVDDDDISDQEDHRSEEKSKEPLQDNVIATYEEHEDSVYAVDWSSADPWLF 363
Query: 299 ASSGTDRRL 307
AS D RL
Sbjct: 364 ASLSYDGRL 372
Score = 42.0 bits (97), Expect = 0.001
Identities = 42/208 (20%), Positives = 74/208 (35%), Gaps = 27/208 (12%)
Query: 169 LWDISAVPKEGKVVDAKTIFTGHTAVVEDVS-WHLLHESLFGS--VADDQKLMIWDTRSN 225
+W ISA P + V+ T + V+ + W + E GS DD + +
Sbjct: 67 IWHISASPADRGVLTTCYNRTSDSKVLTCAAVWRMPKELESGSHESPDDSS-----STAQ 121
Query: 226 NTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDE- 284
H + + C+ + P + AD + LWDL+ + S E
Sbjct: 122 TLELLCHLDNTAHGNMACVVWEPMGDGKKIISLADNHILLWDLQESSSQAVLASSASLEG 181
Query: 285 -----IFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHT 339
+WSPH+ ++ D L WD + + + I H
Sbjct: 182 KGQLKFTSGRWSPHHNCTQVATANDTTLRGWDTRSMSQ-------------IYCIENAHG 228
Query: 340 AKISDFSWNPNEPWVICSVSEDNIMQVW 367
+ D +NPN+ + + S +D ++ W
Sbjct: 229 QLVRDLDFNPNKQYYLASCGDDCKVKFW 256
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.132 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,235,067
Number of Sequences: 37866
Number of extensions: 810292
Number of successful extensions: 3085
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 113
Number of HSP's successfully gapped in prelim test: 187
Number of HSP's that attempted gapping in prelim test: 1608
Number of HSP's gapped (non-prelim): 927
length of query: 390
length of database: 18,247,518
effective HSP length: 104
effective length of query: 286
effective length of database: 14,309,454
effective search space: 4092503844
effective search space used: 4092503844
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.