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Search of human proteins with 205360958
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|205360958 cysteine-rich with EGF-like domains 2 isoform b
[Homo sapiens]
(353 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|205360958 cysteine-rich with EGF-like domains 2 isoform b [Ho... 776 0.0
gi|205360956 cysteine-rich with EGF-like domains 2 isoform a [Ho... 753 0.0
gi|116734855 cysteine-rich with EGF-like domains 1 isoform 3 [Ho... 375 e-104
gi|72534728 cysteine-rich with EGF-like domains 1 isoform 1 [Hom... 375 e-104
gi|22095397 cysteine-rich with EGF-like domains 1 isoform 2 [Hom... 375 e-104
gi|61743980 stabilin 2 precursor [Homo sapiens] 97 3e-20
gi|110347437 latent transforming growth factor beta binding prot... 89 8e-18
gi|110347412 latent transforming growth factor beta binding prot... 89 8e-18
gi|110347431 latent transforming growth factor beta binding prot... 89 8e-18
gi|24430141 fibrillin 1 precursor [Homo sapiens] 88 1e-17
gi|56237021 fibrillin 3 precursor [Homo sapiens] 86 5e-17
gi|66346695 fibrillin 2 precursor [Homo sapiens] 84 1e-16
gi|61743978 stabilin 1 precursor [Homo sapiens] 84 1e-16
gi|126091152 cubilin [Homo sapiens] 83 3e-16
gi|51873055 fibulin 2 isoform b precursor [Homo sapiens] 82 7e-16
gi|20336246 proprotein convertase subtilisin/kexin type 5 prepro... 81 1e-15
gi|34734064 fibulin 1 isoform B precursor [Homo sapiens] 81 2e-15
gi|34734068 fibulin 1 isoform A precursor [Homo sapiens] 81 2e-15
gi|34734066 fibulin 1 isoform D [Homo sapiens] 81 2e-15
gi|34734062 fibulin 1 isoform C precursor [Homo sapiens] 81 2e-15
gi|4557733 latent transforming growth factor beta binding protei... 80 2e-15
gi|115298674 nidogen 1 precursor [Homo sapiens] 80 2e-15
gi|40807489 egf-like module containing, mucin-like, hormone rece... 79 5e-15
gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens] 79 6e-15
gi|190343004 EGF-containing fibulin-like extracellular matrix pr... 79 8e-15
gi|144953895 nidogen 2 precursor [Homo sapiens] 79 8e-15
gi|75709198 nephronectin [Homo sapiens] 79 8e-15
gi|19743803 fibulin 5 precursor [Homo sapiens] 77 2e-14
gi|51873053 fibulin 2 isoform a precursor [Homo sapiens] 77 3e-14
gi|239755070 PREDICTED: similar to proprotein convertase subtili... 76 5e-14
>gi|205360958 cysteine-rich with EGF-like domains 2 isoform b [Homo
sapiens]
Length = 353
Score = 776 bits (2005), Expect = 0.0
Identities = 353/353 (100%), Positives = 353/353 (100%)
Query: 1 MRLPRRAALGLLPLLLLLPPAPEAAKKPTPCHRCRGLVDKFNQGMVDTAKKNFGGGNTAW 60
MRLPRRAALGLLPLLLLLPPAPEAAKKPTPCHRCRGLVDKFNQGMVDTAKKNFGGGNTAW
Sbjct: 1 MRLPRRAALGLLPLLLLLPPAPEAAKKPTPCHRCRGLVDKFNQGMVDTAKKNFGGGNTAW 60
Query: 61 EEKTLSKYESSEIRLLEILEGLCESSDFECNQMLEAQEEHLEAWWLQLKSEYPDLFEWFC 120
EEKTLSKYESSEIRLLEILEGLCESSDFECNQMLEAQEEHLEAWWLQLKSEYPDLFEWFC
Sbjct: 61 EEKTLSKYESSEIRLLEILEGLCESSDFECNQMLEAQEEHLEAWWLQLKSEYPDLFEWFC 120
Query: 121 VKTLKVCCSPGTYGPDCLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDC 180
VKTLKVCCSPGTYGPDCLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDC
Sbjct: 121 VKTLKVCCSPGTYGPDCLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDC 180
Query: 181 MDGYFSSLRNETHSICTACDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDECAAEPPP 240
MDGYFSSLRNETHSICTACDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDECAAEPPP
Sbjct: 181 MDGYFSSLRNETHSICTACDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDECAAEPPP 240
Query: 241 CSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGYAREHGQCADVDECSLAEKT 300
CSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGYAREHGQCADVDECSLAEKT
Sbjct: 241 CSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGYAREHGQCADVDECSLAEKT 300
Query: 301 CVRKNENCYNTPGSYVCVCPDGFEETEDACVPPAEAEATEGESPTQLPSREDL 353
CVRKNENCYNTPGSYVCVCPDGFEETEDACVPPAEAEATEGESPTQLPSREDL
Sbjct: 301 CVRKNENCYNTPGSYVCVCPDGFEETEDACVPPAEAEATEGESPTQLPSREDL 353
>gi|205360956 cysteine-rich with EGF-like domains 2 isoform a [Homo
sapiens]
Length = 402
Score = 753 bits (1945), Expect = 0.0
Identities = 353/402 (87%), Positives = 353/402 (87%), Gaps = 49/402 (12%)
Query: 1 MRLPRRAALGLLPLLLLLPPAPEAAKKPTPCHRCRGLVDKFNQGMVDTAKKNFGGGNTAW 60
MRLPRRAALGLLPLLLLLPPAPEAAKKPTPCHRCRGLVDKFNQGMVDTAKKNFGGGNTAW
Sbjct: 1 MRLPRRAALGLLPLLLLLPPAPEAAKKPTPCHRCRGLVDKFNQGMVDTAKKNFGGGNTAW 60
Query: 61 EEKTLSKYESSEIRLLEILEGLCESSDFECNQMLEAQEEHLEAWWLQLKSEYPDLFEWFC 120
EEKTLSKYESSEIRLLEILEGLCESSDFECNQMLEAQEEHLEAWWLQLKSEYPDLFEWFC
Sbjct: 61 EEKTLSKYESSEIRLLEILEGLCESSDFECNQMLEAQEEHLEAWWLQLKSEYPDLFEWFC 120
Query: 121 VKTLKVCCSPGTYGPDCLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDC 180
VKTLKVCCSPGTYGPDCLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDC
Sbjct: 121 VKTLKVCCSPGTYGPDCLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDC 180
Query: 181 MDGYFSSLRNETHSICT------------------------------------------- 197
MDGYFSSLRNETHSICT
Sbjct: 181 MDGYFSSLRNETHSICTVRTGLSDSYPPCCLSLGCWRGVGHAWIRGRNTHTQPGYSSRVW 240
Query: 198 ------ACDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDECAAEPPPCSAAQFCKNAN 251
ACDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDECAAEPPPCSAAQFCKNAN
Sbjct: 241 IAAFSPACDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDECAAEPPPCSAAQFCKNAN 300
Query: 252 GSYTCEECDSSCVGCTGEGPGNCKECISGYAREHGQCADVDECSLAEKTCVRKNENCYNT 311
GSYTCEECDSSCVGCTGEGPGNCKECISGYAREHGQCADVDECSLAEKTCVRKNENCYNT
Sbjct: 301 GSYTCEECDSSCVGCTGEGPGNCKECISGYAREHGQCADVDECSLAEKTCVRKNENCYNT 360
Query: 312 PGSYVCVCPDGFEETEDACVPPAEAEATEGESPTQLPSREDL 353
PGSYVCVCPDGFEETEDACVPPAEAEATEGESPTQLPSREDL
Sbjct: 361 PGSYVCVCPDGFEETEDACVPPAEAEATEGESPTQLPSREDL 402
>gi|116734855 cysteine-rich with EGF-like domains 1 isoform 3 [Homo
sapiens]
Length = 420
Score = 375 bits (963), Expect = e-104
Identities = 157/313 (50%), Positives = 202/313 (64%), Gaps = 2/313 (0%)
Query: 19 PPAPEAAKKPTPCHRCRGLVDKFNQGMVDTAKKNFGGGNTAWEEKTLSKYESSEIRLLEI 78
PP +P PCH CRGLVD FN+G+ T + NFGGGNTAWEE+ LSKY+ SE RL+E+
Sbjct: 34 PPQSSPPPQPHPCHTCRGLVDSFNKGLERTIRDNFGGGNTAWEEENLSKYKDSETRLVEV 93
Query: 79 LEGLCESSDFECNQMLEAQEEHLEAWWLQLKSEYPDLFEWFCVKTLKVCCSPGTYGPDCL 138
LEG+C SDFEC+++LE EE +E+WW + E PDLF+W C +LK+CC GT+GP CL
Sbjct: 94 LEGVCSKSDFECHRLLELSEELVESWWFHKQQEAPDLFQWLCSDSLKLCCPAGTFGPSCL 153
Query: 139 ACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDCMDGYFSSLRNETHSICTA 198
C GG++RPC G G C G+G+R G G C C GY G C C GYF + RN +H +C+A
Sbjct: 154 PCPGGTERPCGGYGQCEGEGTRGGSGHCDCQAGYGGEACGQCGLGYFEAERNASHLVCSA 213
Query: 199 CDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDECAAEPPPCSAAQFCKNANGSYTCEE 258
C C CSG +C +C+ GW L CVD+DEC E C A QFC N GSY C +
Sbjct: 214 CFGPCARCSGPEESNCLQCKKGWALHHLKCVDIDECGTEGANCGADQFCVNTEGSYECRD 273
Query: 259 CDSSCVGCTGEGPGNCKECISGYAREHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCV 318
C +C+GC G GPG CK+C GY + +C DVDEC + C +N+ C NT G Y C+
Sbjct: 274 CAKACLGCMGAGPGRCKKCSPGYQQVGSKCLDVDECE--TEVCPGENKQCENTEGGYRCI 331
Query: 319 CPDGFEETEDACV 331
C +G+++ E CV
Sbjct: 332 CAEGYKQMEGICV 344
>gi|72534728 cysteine-rich with EGF-like domains 1 isoform 1 [Homo
sapiens]
Length = 422
Score = 375 bits (963), Expect = e-104
Identities = 157/313 (50%), Positives = 202/313 (64%), Gaps = 2/313 (0%)
Query: 19 PPAPEAAKKPTPCHRCRGLVDKFNQGMVDTAKKNFGGGNTAWEEKTLSKYESSEIRLLEI 78
PP +P PCH CRGLVD FN+G+ T + NFGGGNTAWEE+ LSKY+ SE RL+E+
Sbjct: 34 PPQSSPPPQPHPCHTCRGLVDSFNKGLERTIRDNFGGGNTAWEEENLSKYKDSETRLVEV 93
Query: 79 LEGLCESSDFECNQMLEAQEEHLEAWWLQLKSEYPDLFEWFCVKTLKVCCSPGTYGPDCL 138
LEG+C SDFEC+++LE EE +E+WW + E PDLF+W C +LK+CC GT+GP CL
Sbjct: 94 LEGVCSKSDFECHRLLELSEELVESWWFHKQQEAPDLFQWLCSDSLKLCCPAGTFGPSCL 153
Query: 139 ACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDCMDGYFSSLRNETHSICTA 198
C GG++RPC G G C G+G+R G G C C GY G C C GYF + RN +H +C+A
Sbjct: 154 PCPGGTERPCGGYGQCEGEGTRGGSGHCDCQAGYGGEACGQCGLGYFEAERNASHLVCSA 213
Query: 199 CDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDECAAEPPPCSAAQFCKNANGSYTCEE 258
C C CSG +C +C+ GW L CVD+DEC E C A QFC N GSY C +
Sbjct: 214 CFGPCARCSGPEESNCLQCKKGWALHHLKCVDIDECGTEGANCGADQFCVNTEGSYECRD 273
Query: 259 CDSSCVGCTGEGPGNCKECISGYAREHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCV 318
C +C+GC G GPG CK+C GY + +C DVDEC + C +N+ C NT G Y C+
Sbjct: 274 CAKACLGCMGAGPGRCKKCSPGYQQVGSKCLDVDECE--TEVCPGENKQCENTEGGYRCI 331
Query: 319 CPDGFEETEDACV 331
C +G+++ E CV
Sbjct: 332 CAEGYKQMEGICV 344
>gi|22095397 cysteine-rich with EGF-like domains 1 isoform 2 [Homo
sapiens]
Length = 420
Score = 375 bits (963), Expect = e-104
Identities = 157/313 (50%), Positives = 202/313 (64%), Gaps = 2/313 (0%)
Query: 19 PPAPEAAKKPTPCHRCRGLVDKFNQGMVDTAKKNFGGGNTAWEEKTLSKYESSEIRLLEI 78
PP +P PCH CRGLVD FN+G+ T + NFGGGNTAWEE+ LSKY+ SE RL+E+
Sbjct: 34 PPQSSPPPQPHPCHTCRGLVDSFNKGLERTIRDNFGGGNTAWEEENLSKYKDSETRLVEV 93
Query: 79 LEGLCESSDFECNQMLEAQEEHLEAWWLQLKSEYPDLFEWFCVKTLKVCCSPGTYGPDCL 138
LEG+C SDFEC+++LE EE +E+WW + E PDLF+W C +LK+CC GT+GP CL
Sbjct: 94 LEGVCSKSDFECHRLLELSEELVESWWFHKQQEAPDLFQWLCSDSLKLCCPAGTFGPSCL 153
Query: 139 ACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDCMDGYFSSLRNETHSICTA 198
C GG++RPC G G C G+G+R G G C C GY G C C GYF + RN +H +C+A
Sbjct: 154 PCPGGTERPCGGYGQCEGEGTRGGSGHCDCQAGYGGEACGQCGLGYFEAERNASHLVCSA 213
Query: 199 CDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDECAAEPPPCSAAQFCKNANGSYTCEE 258
C C CSG +C +C+ GW L CVD+DEC E C A QFC N GSY C +
Sbjct: 214 CFGPCARCSGPEESNCLQCKKGWALHHLKCVDIDECGTEGANCGADQFCVNTEGSYECRD 273
Query: 259 CDSSCVGCTGEGPGNCKECISGYAREHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCV 318
C +C+GC G GPG CK+C GY + +C DVDEC + C +N+ C NT G Y C+
Sbjct: 274 CAKACLGCMGAGPGRCKKCSPGYQQVGSKCLDVDECE--TEVCPGENKQCENTEGGYRCI 331
Query: 319 CPDGFEETEDACV 331
C +G+++ E CV
Sbjct: 332 CAEGYKQMEGICV 344
>gi|61743980 stabilin 2 precursor [Homo sapiens]
Length = 2551
Score = 96.7 bits (239), Expect = 3e-20
Identities = 70/244 (28%), Positives = 94/244 (38%), Gaps = 38/244 (15%)
Query: 119 FCVKTLKV--CCSPGTYGPDCLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPL 176
+C T+K+ CC G YGPDC C GG PCSGNG C+ S G+G+C C G+QG
Sbjct: 718 YCNATVKIPKCCK-GFYGPDCNQCPGGFSNPCSGNGQCA--DSLGGNGTCICEEGFQGSQ 774
Query: 177 CTDCMDGYFSSLRNETHSICT--ACDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDEC 234
C C D R +C C+ + C + G + D+ C
Sbjct: 775 CQFCSDPNKYGPRCNKKCLCVHGTCNNRIDSDGACLTGTCRDGSAGRLCDK----QTSAC 830
Query: 235 AAEPPPCSAAQFCKNANGSYTCEECDSSCVG----------CTGEGPGNCK---ECI--- 278
C C+ +NG+ +C C + G CTG PG C ECI
Sbjct: 831 GPYVQFCHIHATCEYSNGTASC-ICKAGYEGDGTLCSEMDPCTGLTPGGCSRNAECIKTG 889
Query: 279 ---------SGYAREHGQCADVDECSLAEKTCVRKNENC-YNTPGSYVCVCPDGFEETED 328
G+ C++++ C L N +C Y PG C C GF
Sbjct: 890 TGTHTCVCQQGWTGNGRDCSEINNCLLPSAGGCHDNASCLYVGPGQNECECKKGFRGNGI 949
Query: 329 ACVP 332
C P
Sbjct: 950 DCEP 953
Score = 90.9 bits (224), Expect = 2e-18
Identities = 59/224 (26%), Positives = 89/224 (39%), Gaps = 37/224 (16%)
Query: 128 CSPGTYGPDCLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDCMDGYF-- 185
C PG +GPDC+ C GG+ PC+G G C+ +G+G+C C G+ G C C D
Sbjct: 100 CCPGRWGPDCIECPGGAGSPCNGRGSCA--EGMEGNGTCSCQEGFGGTACETCADDNLFG 157
Query: 186 ---SSLRNETHSICTACDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDECAAEPPPCS 242
SS+ N H +C + + TC +C G +C P C+
Sbjct: 158 PSCSSVCNCVHGVCNSGLDGDGTC------ECYSAYTG-----------PKCDKPIPECA 200
Query: 243 AAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGYAREHGQCADVDECSLAEKTCV 302
A +N+ S + E+ E CK C+ Y + C ++ C K C
Sbjct: 201 ALLCPENSRCSPSTED----------ENKLECK-CLPNYRGDGKYCDPINPC--LRKICH 247
Query: 303 RKNENCYNTPGSYVCVCPDGFEETEDACVPPAEAEATEGESPTQ 346
Y P + C C +G+ C+P + G PT+
Sbjct: 248 PHAHCTYLGPNRHSCTCQEGYRGDGQVCLPVDPCQINFGNCPTK 291
Score = 88.2 bits (217), Expect = 1e-17
Identities = 63/220 (28%), Positives = 91/220 (41%), Gaps = 42/220 (19%)
Query: 120 CVKTL--KVCCSPGTYGPDCLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLC 177
CV+T+ + CC+ G +GP C C G +Q C GNG C DG G G C C G+ G C
Sbjct: 1327 CVRTVITRECCA-GFFGPQCQPCPGNAQNVCFGNGICL-DGV-NGTGVCECGEGFSGTAC 1383
Query: 178 TDCMDGYFSSLRNETHSICTACDESCKTCSGLTNR------DCGECEVGWVLDEGACVDV 231
C +G + CD++C G N+ C +C+VGW
Sbjct: 1384 ETCTEGKYG----------IHCDQACSCVHGRCNQGPLGDGSC-DCDVGW---------- 1422
Query: 232 DECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGYAREHGQCADV 291
C A N NG TC ++C+ +G +CK C +G+ C +
Sbjct: 1423 -----RGVHCDNATTEDNCNG--TC-HTSANCL-TNSDGTASCK-CAAGFQGNGTICTAI 1472
Query: 292 DECSLAEKTCVRKNENCYNTPGSYVCVCPDGFEETEDACV 331
+ C ++ C K + TPG VC C G+ C+
Sbjct: 1473 NACEISNGGCSAKADCKRTTPGRRVCTCKAGYTGDGIVCL 1512
Score = 82.4 bits (202), Expect = 6e-16
Identities = 60/227 (26%), Positives = 81/227 (35%), Gaps = 32/227 (14%)
Query: 128 CSPGTYGPDCLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDCMDGYFSS 187
C G +G DC AC GG PC+ G C S G+ C+C+ G+ G C C G F
Sbjct: 1950 CCKGYFGRDCQACPGGPDAPCNNRGVCLDQYSATGE--CKCNTGFNGTACEMCWPGRFG- 2006
Query: 188 LRNETHSICTACDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDEC--AAEPPPCSAAQ 245
+ C + + G+T CE GW G D A PPCSA
Sbjct: 2007 ----PDCLPCGCSDHGQCDDGITGSGQCLCETGWT---GPSCDTQAVLPAVCTPPCSAHA 2059
Query: 246 FCKNAN----------GSYTCEECD---------SSCVGCTGEGPGNCKECISGYAREHG 286
CK N TC D + C+ +G C GY +
Sbjct: 2060 TCKENNTCECNLDYEGDGITCTVVDFCKQDNGGCAKVARCSQKGTKVSCSCQKGYKGDGH 2119
Query: 287 QCADVDECSLAEKTCVRKNENCYNT-PGSYVCVCPDGFEETEDACVP 332
C ++D C+ ++ C T PG + C C + C P
Sbjct: 2120 SCTEIDPCADGLNGGCHEHATCKMTGPGKHKCECKSHYVGDGLNCEP 2166
Score = 39.7 bits (91), Expect = 0.004
Identities = 45/197 (22%), Positives = 63/197 (31%), Gaps = 57/197 (28%)
Query: 183 GYFSSLRNETHSICTACDESCKTCSGLTNRDCGECEVGW---VLDEGACVDV----DECA 235
G F SL++ C A + K C G DC +C G+ G C D C
Sbjct: 706 GRFGSLKSGCARYCNATVKIPKCCKGFYGPDCNQCPGGFSNPCSGNGQCADSLGGNGTCI 765
Query: 236 AEPP-PCSAAQFCKNANG---------------------------SYTCEE------CDS 261
E S QFC + N + TC + CD
Sbjct: 766 CEEGFQGSQCQFCSDPNKYGPRCNKKCLCVHGTCNNRIDSDGACLTGTCRDGSAGRLCDK 825
Query: 262 SCVGC--------------TGEGPGNCKECISGYAREHGQCADVDECS-LAEKTCVRKNE 306
C G +C C +GY + C+++D C+ L C R E
Sbjct: 826 QTSACGPYVQFCHIHATCEYSNGTASC-ICKAGYEGDGTLCSEMDPCTGLTPGGCSRNAE 884
Query: 307 NCYNTPGSYVCVCPDGF 323
G++ CVC G+
Sbjct: 885 CIKTGTGTHTCVCQQGW 901
Score = 35.4 bits (80), Expect = 0.078
Identities = 52/220 (23%), Positives = 72/220 (32%), Gaps = 42/220 (19%)
Query: 143 GSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDCMDGYFSSLRNETHSICTACDES 202
G R CS C G+ RC YF R ++ C
Sbjct: 1282 GRCRTCSSELTCPFGTKSLGNEKRRC-----------IYTSYFMGRR----TLFIGCQPK 1326
Query: 203 C-------KTCSGLTNRDCGECE---VGWVLDEGACVD------VDECAAEPPPCSAAQF 246
C + C+G C C G C+D V EC E +A +
Sbjct: 1327 CVRTVITRECCAGFFGPQCQPCPGNAQNVCFGNGICLDGVNGTGVCECG-EGFSGTACET 1385
Query: 247 CKNANGSYTCEECDSSCVGCTGEGP---GNCKECISGYAREHGQCADV-DECSLAEKTCV 302
C C++ S G +GP G+C +C G+ H A D C+ TC
Sbjct: 1386 CTEGKYGIHCDQACSCVHGRCNQGPLGDGSC-DCDVGWRGVHCDNATTEDNCN---GTC- 1440
Query: 303 RKNENCY-NTPGSYVCVCPDGFEETEDACVPPAEAEATEG 341
+ NC N+ G+ C C GF+ C E + G
Sbjct: 1441 HTSANCLTNSDGTASCKCAAGFQGNGTICTAINACEISNG 1480
Score = 33.9 bits (76), Expect = 0.23
Identities = 40/165 (24%), Positives = 51/165 (30%), Gaps = 53/165 (32%)
Query: 199 CDESC-------KTCSGLTNRDCGECEVG---WVLDEGACVDVDECAAEPPPCSAAQFCK 248
C E C + C G RDC C G + G C+D E C C
Sbjct: 1937 CRERCSLVIQIPRCCKGYFGRDCQACPGGPDAPCNNRGVCLDQYSATGE---CK----CN 1989
Query: 249 NANGSYTCEECDSSCVGCTGEGPGNCKECISGYAREHGQCADVDECSLAEKTCVRKNENC 308
CE C G +C+ +HGQC D
Sbjct: 1990 TGFNGTACEMCWPGRFG---------PDCLPCGCSDHGQCDD------------------ 2022
Query: 309 YNTPGSYVCVCPDGFE----ETE----DACVPPAEAEATEGESPT 345
GS C+C G+ +T+ C PP A AT E+ T
Sbjct: 2023 -GITGSGQCLCETGWTGPSCDTQAVLPAVCTPPCSAHATCKENNT 2066
>gi|110347437 latent transforming growth factor beta binding protein 4
isoform c [Homo sapiens]
Length = 1557
Score = 88.6 bits (218), Expect = 8e-18
Identities = 74/251 (29%), Positives = 102/251 (40%), Gaps = 41/251 (16%)
Query: 130 PGTYGPDCLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQ-GPLCTDCMDGYFSSL 188
PG G CL S+ +G C+ + G C C G++ GP C+D
Sbjct: 844 PGPRGASCLDVDECSEEDLCQSGICT---NTDGSFECICPPGHRAGPDLASCLD--VDEC 898
Query: 189 RNETHSICTACDESCKTCSGLTNRDCGECEVGWVLD-EGACVDVDECAAEPPPCSAAQFC 247
R ++C + + C+ G + R +C+ G+ EG C DVDEC P AQ C
Sbjct: 899 RERGPALCGS--QRCENSPG-SYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRC 955
Query: 248 KNANGSYTC-EECDSSCVGCTGEGPGNCKECIS-----------------------GY-- 281
+N GSY C CD G G + EC + GY
Sbjct: 956 ENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEG 1015
Query: 282 AREHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFEETE---DACVPPAEAEA 338
AR+ C DV+EC + C C N GS++CVCP+ EE + CVPP +
Sbjct: 1016 ARDGRHCVDVNECETLQGVC--GAALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAG 1073
Query: 339 TEGESPTQLPS 349
T S Q P+
Sbjct: 1074 TFPGSQPQAPA 1084
Score = 81.3 bits (199), Expect = 1e-15
Identities = 71/231 (30%), Positives = 89/231 (38%), Gaps = 53/231 (22%)
Query: 130 PGTYGPDCLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQ----GPLCTDCMDGYF 185
PG D C S PC+ G C + +G C C MG+Q G C D +
Sbjct: 679 PGAPCQDVDEC-ARSPPPCT-YGRCE---NTEGSFQCVCPMGFQPNTAGSECEDVDEC-- 731
Query: 186 SSLRNETHSICTACDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDECAAEPPPCSAAQ 245
E H C + C G + C C G L G C DVDEC++ PPC
Sbjct: 732 -----ENHLACPG--QECVNSPG--SFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHG 782
Query: 246 FCKNANGSYTCEECDSSCVGCTGEGPGNC---KECISG-YAREHGQ-------------- 287
C N GS+ C C +G PG C EC+ G + HG+
Sbjct: 783 HCTNTEGSFRC-SCAPGYRAPSGR-PGPCADVNECLEGDFCFPHGECLNTDGSFACTCAP 840
Query: 288 ----------CADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFEETED 328
C DVDECS E C ++ C NT GS+ C+CP G D
Sbjct: 841 GYRPGPRGASCLDVDECS-EEDLC--QSGICTNTDGSFECICPPGHRAGPD 888
Score = 78.6 bits (192), Expect = 8e-15
Identities = 72/220 (32%), Positives = 90/220 (40%), Gaps = 48/220 (21%)
Query: 130 PGTYGPDCLACQGGSQRPCSGNGHCSGDG---SRQGDGSCRCHMGYQ-GPLCTDCMDGYF 185
P GP+ + G S C N G G SR +C C G++ P T C+D
Sbjct: 465 PAWTGPE-IPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDV-- 521
Query: 186 SSLRNETHSICTACDES-CKTCSGLTNRDCGECEVGWVLDEGA--CVDVDECAAEPPPCS 242
+E + C C+ G CG G+ A C+DVDEC PPPC
Sbjct: 522 ----DECRRVPPPCAPGRCENSPGSFRCVCGP---GFRAGPRAAECLDVDECHRVPPPCD 574
Query: 243 AAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGY-AREHG-QCADVDECSLAEKT 300
+ C+N GS+ C C +GY A HG C DVDEC+ +
Sbjct: 575 LGR-CENTPGSFLCV-------------------CPAGYQAAPHGASCQDVDECTQSPGL 614
Query: 301 CVRKNENCYNTPGSYVCVCPDGF-----EETEDACV--PP 333
C R C N PGS+ CVCP GF EE D C PP
Sbjct: 615 CGRGA--CKNLPGSFRCVCPAGFRGSACEEDVDECAQEPP 652
Score = 72.4 bits (176), Expect = 6e-13
Identities = 65/209 (31%), Positives = 79/209 (37%), Gaps = 40/209 (19%)
Query: 123 TLKVCCSPG-TYGPDCLACQGGSQ-----RPCSGNGHCSGDGSRQGDGSCRCHMGYQG-P 175
+ + C PG GP C + PC G C + G C C GYQ P
Sbjct: 542 SFRCVCGPGFRAGPRAAECLDVDECHRVPPPCD-LGRCE---NTPGSFLCVCPAGYQAAP 597
Query: 176 LCTDCMDGYFSSLRNETHSICTACDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDECA 235
C D + T S +CK G C G +E DVDECA
Sbjct: 598 HGASCQD-----VDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEE----DVDECA 648
Query: 236 AEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGYAREHGQCADVDECS 295
EPPPC + C N GS+ C + G GPG C DVDEC+
Sbjct: 649 QEPPPCGPGR-CDNTAGSFHC----ACPAGFRSRGPG-------------APCQDVDECA 690
Query: 296 LAEKTCVRKNENCYNTPGSYVCVCPDGFE 324
+ C C NT GS+ CVCP GF+
Sbjct: 691 RSPPPCT--YGRCENTEGSFQCVCPMGFQ 717
Score = 67.0 bits (162), Expect = 2e-11
Identities = 45/134 (33%), Positives = 60/134 (44%), Gaps = 28/134 (20%)
Query: 217 CEVGWVLDEGA--CVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNC 274
C+ G+ L C+DVDEC PPPC+ + C+N+ GS+ C C GPG
Sbjct: 505 CDSGFRLSPQGTRCIDVDECRRVPPPCAPGR-CENSPGSFRCV--------C---GPG-- 550
Query: 275 KECISGYAREHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFEETEDACVPPA 334
+C DVDEC C C NTPGS++CVCP G++ P
Sbjct: 551 ----FRAGPRAAECLDVDECHRVPPPC--DLGRCENTPGSFLCVCPAGYQ------AAPH 598
Query: 335 EAEATEGESPTQLP 348
A + + TQ P
Sbjct: 599 GASCQDVDECTQSP 612
Score = 57.8 bits (138), Expect = 1e-08
Identities = 34/105 (32%), Positives = 51/105 (48%), Gaps = 10/105 (9%)
Query: 233 ECAAEPPPCSAAQFCKN----ANGSYTCEECDSSCVGCTGEGPGNCKECISGYAREHGQC 288
ECA+ P + C A G + C+ C S +G + C +G+ R +G C
Sbjct: 230 ECASPLPGLRTQEVCCRGAGLAWGVHDCQLC-SERLGNSERVSAPDGPCPTGFERVNGSC 288
Query: 289 ADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGF--EETEDACV 331
DVDEC+ + ++ C NT G Y CVCPDGF + + +C+
Sbjct: 289 EDVDECATGGRC---QHGECANTRGGYTCVCPDGFLLDSSRSSCI 330
Score = 42.7 bits (99), Expect = 5e-04
Identities = 30/87 (34%), Positives = 36/87 (41%), Gaps = 13/87 (14%)
Query: 257 EECD--SSCVG--CTGEGPGNCKECISGYAREHGQ--CADVDECSLAEKT---CVRKNEN 307
EEC C C G C GY + + C D++EC AE CV N
Sbjct: 1468 EECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCV--NAR 1525
Query: 308 CYNTPGSYVCVCPDGFEETEDA--CVP 332
C NT GS+ C+C GF T C P
Sbjct: 1526 CLNTDGSFRCICRPGFAPTHQPHHCAP 1552
Score = 40.4 bits (93), Expect = 0.002
Identities = 21/56 (37%), Positives = 26/56 (46%), Gaps = 4/56 (7%)
Query: 266 CTGEGPGNCKECISGYA--REHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCVC 319
C PG C +GY + +C D DEC+ E C + C NT GSY C C
Sbjct: 1203 CVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPAC--EGGRCVNTVGSYHCTC 1256
Score = 38.9 bits (89), Expect = 0.007
Identities = 28/89 (31%), Positives = 35/89 (39%), Gaps = 13/89 (14%)
Query: 196 CTACDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDECAAEPPPCSAAQFCKNANGSYT 255
C C E ++ D G C G+ G+C DVDECA C + C N G YT
Sbjct: 257 CQLCSERLGNSERVSAPD-GPCPTGFERVNGSCEDVDECAT-GGRCQHGE-CANTRGGYT 313
Query: 256 C--------EECDSSCVG--CTGEGPGNC 274
C + SSC+ E G C
Sbjct: 314 CVCPDGFLLDSSRSSCISQHVISEAKGPC 342
Score = 35.4 bits (80), Expect = 0.078
Identities = 36/135 (26%), Positives = 46/135 (34%), Gaps = 25/135 (18%)
Query: 127 CCSPGT-YGPDCLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDCMDGYF 185
CC+ G +G C Q C G + + C GY P
Sbjct: 1140 CCTVGEGWGSGCRIQQ------------CPGTETAEYQSLCPHGRGYLAPSGD------- 1180
Query: 186 SSLRNETHSICTACDESCKT--CSGLTNRDCGECEVGWVLDEGA--CVDVDECAAEPPPC 241
SLR + D+ CK+ C C G+ C+D DECA E P C
Sbjct: 1181 LSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPAC 1240
Query: 242 SAAQFCKNANGSYTC 256
+ C N GSY C
Sbjct: 1241 EGGR-CVNTVGSYHC 1254
Score = 33.9 bits (76), Expect = 0.23
Identities = 25/69 (36%), Positives = 31/69 (44%), Gaps = 14/69 (20%)
Query: 201 ESCKTCSGLTNRDCGE--------CEVGWVLD--EGACVDVDEC---AAEPPPCSAAQFC 247
E C G TN C C G+ LD ACVD++EC A P C A+ C
Sbjct: 1468 EECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR-C 1526
Query: 248 KNANGSYTC 256
N +GS+ C
Sbjct: 1527 LNTDGSFRC 1535
Score = 31.2 bits (69), Expect = 1.5
Identities = 18/48 (37%), Positives = 24/48 (50%), Gaps = 6/48 (12%)
Query: 280 GYAREHGQCA---DVDECSL-AEKTCVRKNENCYNTPGSYVCVCPDGF 323
GY G + DVDEC L ++ C K+ C NT Y C C +G+
Sbjct: 1173 GYLAPSGDLSLRRDVDECQLFRDQVC--KSGVCVNTAPGYSCYCSNGY 1218
>gi|110347412 latent transforming growth factor beta binding protein 4
isoform b [Homo sapiens]
Length = 1587
Score = 88.6 bits (218), Expect = 8e-18
Identities = 74/251 (29%), Positives = 102/251 (40%), Gaps = 41/251 (16%)
Query: 130 PGTYGPDCLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQ-GPLCTDCMDGYFSSL 188
PG G CL S+ +G C+ + G C C G++ GP C+D
Sbjct: 874 PGPRGASCLDVDECSEEDLCQSGICT---NTDGSFECICPPGHRAGPDLASCLD--VDEC 928
Query: 189 RNETHSICTACDESCKTCSGLTNRDCGECEVGWVLD-EGACVDVDECAAEPPPCSAAQFC 247
R ++C + + C+ G + R +C+ G+ EG C DVDEC P AQ C
Sbjct: 929 RERGPALCGS--QRCENSPG-SYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRC 985
Query: 248 KNANGSYTC-EECDSSCVGCTGEGPGNCKECIS-----------------------GY-- 281
+N GSY C CD G G + EC + GY
Sbjct: 986 ENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEG 1045
Query: 282 AREHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFEETE---DACVPPAEAEA 338
AR+ C DV+EC + C C N GS++CVCP+ EE + CVPP +
Sbjct: 1046 ARDGRHCVDVNECETLQGVC--GAALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAG 1103
Query: 339 TEGESPTQLPS 349
T S Q P+
Sbjct: 1104 TFPGSQPQAPA 1114
Score = 81.3 bits (199), Expect = 1e-15
Identities = 71/231 (30%), Positives = 89/231 (38%), Gaps = 53/231 (22%)
Query: 130 PGTYGPDCLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQ----GPLCTDCMDGYF 185
PG D C S PC+ G C + +G C C MG+Q G C D +
Sbjct: 709 PGAPCQDVDEC-ARSPPPCT-YGRCE---NTEGSFQCVCPMGFQPNTAGSECEDVDEC-- 761
Query: 186 SSLRNETHSICTACDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDECAAEPPPCSAAQ 245
E H C + C G + C C G L G C DVDEC++ PPC
Sbjct: 762 -----ENHLACPG--QECVNSPG--SFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHG 812
Query: 246 FCKNANGSYTCEECDSSCVGCTGEGPGNC---KECISG-YAREHGQ-------------- 287
C N GS+ C C +G PG C EC+ G + HG+
Sbjct: 813 HCTNTEGSFRC-SCAPGYRAPSGR-PGPCADVNECLEGDFCFPHGECLNTDGSFACTCAP 870
Query: 288 ----------CADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFEETED 328
C DVDECS E C ++ C NT GS+ C+CP G D
Sbjct: 871 GYRPGPRGASCLDVDECS-EEDLC--QSGICTNTDGSFECICPPGHRAGPD 918
Score = 78.6 bits (192), Expect = 8e-15
Identities = 72/220 (32%), Positives = 90/220 (40%), Gaps = 48/220 (21%)
Query: 130 PGTYGPDCLACQGGSQRPCSGNGHCSGDG---SRQGDGSCRCHMGYQ-GPLCTDCMDGYF 185
P GP+ + G S C N G G SR +C C G++ P T C+D
Sbjct: 495 PAWTGPE-IPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDV-- 551
Query: 186 SSLRNETHSICTACDES-CKTCSGLTNRDCGECEVGWVLDEGA--CVDVDECAAEPPPCS 242
+E + C C+ G CG G+ A C+DVDEC PPPC
Sbjct: 552 ----DECRRVPPPCAPGRCENSPGSFRCVCGP---GFRAGPRAAECLDVDECHRVPPPCD 604
Query: 243 AAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGY-AREHG-QCADVDECSLAEKT 300
+ C+N GS+ C C +GY A HG C DVDEC+ +
Sbjct: 605 LGR-CENTPGSFLCV-------------------CPAGYQAAPHGASCQDVDECTQSPGL 644
Query: 301 CVRKNENCYNTPGSYVCVCPDGF-----EETEDACV--PP 333
C R C N PGS+ CVCP GF EE D C PP
Sbjct: 645 CGRGA--CKNLPGSFRCVCPAGFRGSACEEDVDECAQEPP 682
Score = 72.4 bits (176), Expect = 6e-13
Identities = 65/209 (31%), Positives = 79/209 (37%), Gaps = 40/209 (19%)
Query: 123 TLKVCCSPG-TYGPDCLACQGGSQ-----RPCSGNGHCSGDGSRQGDGSCRCHMGYQG-P 175
+ + C PG GP C + PC G C + G C C GYQ P
Sbjct: 572 SFRCVCGPGFRAGPRAAECLDVDECHRVPPPCD-LGRCE---NTPGSFLCVCPAGYQAAP 627
Query: 176 LCTDCMDGYFSSLRNETHSICTACDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDECA 235
C D + T S +CK G C G +E DVDECA
Sbjct: 628 HGASCQD-----VDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEE----DVDECA 678
Query: 236 AEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGYAREHGQCADVDECS 295
EPPPC + C N GS+ C + G GPG C DVDEC+
Sbjct: 679 QEPPPCGPGR-CDNTAGSFHC----ACPAGFRSRGPG-------------APCQDVDECA 720
Query: 296 LAEKTCVRKNENCYNTPGSYVCVCPDGFE 324
+ C C NT GS+ CVCP GF+
Sbjct: 721 RSPPPCT--YGRCENTEGSFQCVCPMGFQ 747
Score = 67.0 bits (162), Expect = 2e-11
Identities = 45/134 (33%), Positives = 60/134 (44%), Gaps = 28/134 (20%)
Query: 217 CEVGWVLDEGA--CVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNC 274
C+ G+ L C+DVDEC PPPC+ + C+N+ GS+ C C GPG
Sbjct: 535 CDSGFRLSPQGTRCIDVDECRRVPPPCAPGR-CENSPGSFRCV--------C---GPG-- 580
Query: 275 KECISGYAREHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFEETEDACVPPA 334
+C DVDEC C C NTPGS++CVCP G++ P
Sbjct: 581 ----FRAGPRAAECLDVDECHRVPPPC--DLGRCENTPGSFLCVCPAGYQ------AAPH 628
Query: 335 EAEATEGESPTQLP 348
A + + TQ P
Sbjct: 629 GASCQDVDECTQSP 642
Score = 57.8 bits (138), Expect = 1e-08
Identities = 34/105 (32%), Positives = 51/105 (48%), Gaps = 10/105 (9%)
Query: 233 ECAAEPPPCSAAQFCKN----ANGSYTCEECDSSCVGCTGEGPGNCKECISGYAREHGQC 288
ECA+ P + C A G + C+ C S +G + C +G+ R +G C
Sbjct: 260 ECASPLPGLRTQEVCCRGAGLAWGVHDCQLC-SERLGNSERVSAPDGPCPTGFERVNGSC 318
Query: 289 ADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGF--EETEDACV 331
DVDEC+ + ++ C NT G Y CVCPDGF + + +C+
Sbjct: 319 EDVDECATGGRC---QHGECANTRGGYTCVCPDGFLLDSSRSSCI 360
Score = 42.7 bits (99), Expect = 5e-04
Identities = 30/87 (34%), Positives = 36/87 (41%), Gaps = 13/87 (14%)
Query: 257 EECD--SSCVG--CTGEGPGNCKECISGYAREHGQ--CADVDECSLAEKT---CVRKNEN 307
EEC C C G C GY + + C D++EC AE CV N
Sbjct: 1498 EECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCV--NAR 1555
Query: 308 CYNTPGSYVCVCPDGFEETEDA--CVP 332
C NT GS+ C+C GF T C P
Sbjct: 1556 CLNTDGSFRCICRPGFAPTHQPHHCAP 1582
Score = 40.4 bits (93), Expect = 0.002
Identities = 21/56 (37%), Positives = 26/56 (46%), Gaps = 4/56 (7%)
Query: 266 CTGEGPGNCKECISGYA--REHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCVC 319
C PG C +GY + +C D DEC+ E C + C NT GSY C C
Sbjct: 1233 CVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPAC--EGGRCVNTVGSYHCTC 1286
Score = 38.9 bits (89), Expect = 0.007
Identities = 28/89 (31%), Positives = 35/89 (39%), Gaps = 13/89 (14%)
Query: 196 CTACDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDECAAEPPPCSAAQFCKNANGSYT 255
C C E ++ D G C G+ G+C DVDECA C + C N G YT
Sbjct: 287 CQLCSERLGNSERVSAPD-GPCPTGFERVNGSCEDVDECAT-GGRCQHGE-CANTRGGYT 343
Query: 256 C--------EECDSSCVG--CTGEGPGNC 274
C + SSC+ E G C
Sbjct: 344 CVCPDGFLLDSSRSSCISQHVISEAKGPC 372
Score = 35.4 bits (80), Expect = 0.078
Identities = 36/135 (26%), Positives = 46/135 (34%), Gaps = 25/135 (18%)
Query: 127 CCSPGT-YGPDCLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDCMDGYF 185
CC+ G +G C Q C G + + C GY P
Sbjct: 1170 CCTVGEGWGSGCRIQQ------------CPGTETAEYQSLCPHGRGYLAPSGD------- 1210
Query: 186 SSLRNETHSICTACDESCKT--CSGLTNRDCGECEVGWVLDEGA--CVDVDECAAEPPPC 241
SLR + D+ CK+ C C G+ C+D DECA E P C
Sbjct: 1211 LSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPAC 1270
Query: 242 SAAQFCKNANGSYTC 256
+ C N GSY C
Sbjct: 1271 EGGR-CVNTVGSYHC 1284
Score = 33.9 bits (76), Expect = 0.23
Identities = 25/69 (36%), Positives = 31/69 (44%), Gaps = 14/69 (20%)
Query: 201 ESCKTCSGLTNRDCGE--------CEVGWVLD--EGACVDVDEC---AAEPPPCSAAQFC 247
E C G TN C C G+ LD ACVD++EC A P C A+ C
Sbjct: 1498 EECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR-C 1556
Query: 248 KNANGSYTC 256
N +GS+ C
Sbjct: 1557 LNTDGSFRC 1565
Score = 31.2 bits (69), Expect = 1.5
Identities = 18/48 (37%), Positives = 24/48 (50%), Gaps = 6/48 (12%)
Query: 280 GYAREHGQCA---DVDECSL-AEKTCVRKNENCYNTPGSYVCVCPDGF 323
GY G + DVDEC L ++ C K+ C NT Y C C +G+
Sbjct: 1203 GYLAPSGDLSLRRDVDECQLFRDQVC--KSGVCVNTAPGYSCYCSNGY 1248
>gi|110347431 latent transforming growth factor beta binding protein 4
isoform a [Homo sapiens]
Length = 1624
Score = 88.6 bits (218), Expect = 8e-18
Identities = 74/251 (29%), Positives = 102/251 (40%), Gaps = 41/251 (16%)
Query: 130 PGTYGPDCLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQ-GPLCTDCMDGYFSSL 188
PG G CL S+ +G C+ + G C C G++ GP C+D
Sbjct: 911 PGPRGASCLDVDECSEEDLCQSGICT---NTDGSFECICPPGHRAGPDLASCLD--VDEC 965
Query: 189 RNETHSICTACDESCKTCSGLTNRDCGECEVGWVLD-EGACVDVDECAAEPPPCSAAQFC 247
R ++C + + C+ G + R +C+ G+ EG C DVDEC P AQ C
Sbjct: 966 RERGPALCGS--QRCENSPG-SYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRC 1022
Query: 248 KNANGSYTC-EECDSSCVGCTGEGPGNCKECIS-----------------------GY-- 281
+N GSY C CD G G + EC + GY
Sbjct: 1023 ENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEG 1082
Query: 282 AREHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFEETE---DACVPPAEAEA 338
AR+ C DV+EC + C C N GS++CVCP+ EE + CVPP +
Sbjct: 1083 ARDGRHCVDVNECETLQGVC--GAALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAG 1140
Query: 339 TEGESPTQLPS 349
T S Q P+
Sbjct: 1141 TFPGSQPQAPA 1151
Score = 81.3 bits (199), Expect = 1e-15
Identities = 71/231 (30%), Positives = 89/231 (38%), Gaps = 53/231 (22%)
Query: 130 PGTYGPDCLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQ----GPLCTDCMDGYF 185
PG D C S PC+ G C + +G C C MG+Q G C D +
Sbjct: 746 PGAPCQDVDEC-ARSPPPCT-YGRCE---NTEGSFQCVCPMGFQPNTAGSECEDVDEC-- 798
Query: 186 SSLRNETHSICTACDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDECAAEPPPCSAAQ 245
E H C + C G + C C G L G C DVDEC++ PPC
Sbjct: 799 -----ENHLACPG--QECVNSPG--SFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHG 849
Query: 246 FCKNANGSYTCEECDSSCVGCTGEGPGNC---KECISG-YAREHGQ-------------- 287
C N GS+ C C +G PG C EC+ G + HG+
Sbjct: 850 HCTNTEGSFRC-SCAPGYRAPSGR-PGPCADVNECLEGDFCFPHGECLNTDGSFACTCAP 907
Query: 288 ----------CADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFEETED 328
C DVDECS E C ++ C NT GS+ C+CP G D
Sbjct: 908 GYRPGPRGASCLDVDECS-EEDLC--QSGICTNTDGSFECICPPGHRAGPD 955
Score = 78.6 bits (192), Expect = 8e-15
Identities = 72/220 (32%), Positives = 90/220 (40%), Gaps = 48/220 (21%)
Query: 130 PGTYGPDCLACQGGSQRPCSGNGHCSGDG---SRQGDGSCRCHMGYQ-GPLCTDCMDGYF 185
P GP+ + G S C N G G SR +C C G++ P T C+D
Sbjct: 532 PAWTGPE-IPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDV-- 588
Query: 186 SSLRNETHSICTACDES-CKTCSGLTNRDCGECEVGWVLDEGA--CVDVDECAAEPPPCS 242
+E + C C+ G CG G+ A C+DVDEC PPPC
Sbjct: 589 ----DECRRVPPPCAPGRCENSPGSFRCVCGP---GFRAGPRAAECLDVDECHRVPPPCD 641
Query: 243 AAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGY-AREHG-QCADVDECSLAEKT 300
+ C+N GS+ C C +GY A HG C DVDEC+ +
Sbjct: 642 LGR-CENTPGSFLCV-------------------CPAGYQAAPHGASCQDVDECTQSPGL 681
Query: 301 CVRKNENCYNTPGSYVCVCPDGF-----EETEDACV--PP 333
C R C N PGS+ CVCP GF EE D C PP
Sbjct: 682 CGRGA--CKNLPGSFRCVCPAGFRGSACEEDVDECAQEPP 719
Score = 72.4 bits (176), Expect = 6e-13
Identities = 65/209 (31%), Positives = 79/209 (37%), Gaps = 40/209 (19%)
Query: 123 TLKVCCSPG-TYGPDCLACQGGSQ-----RPCSGNGHCSGDGSRQGDGSCRCHMGYQG-P 175
+ + C PG GP C + PC G C + G C C GYQ P
Sbjct: 609 SFRCVCGPGFRAGPRAAECLDVDECHRVPPPCD-LGRCE---NTPGSFLCVCPAGYQAAP 664
Query: 176 LCTDCMDGYFSSLRNETHSICTACDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDECA 235
C D + T S +CK G C G +E DVDECA
Sbjct: 665 HGASCQD-----VDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEE----DVDECA 715
Query: 236 AEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGYAREHGQCADVDECS 295
EPPPC + C N GS+ C + G GPG C DVDEC+
Sbjct: 716 QEPPPCGPGR-CDNTAGSFHC----ACPAGFRSRGPG-------------APCQDVDECA 757
Query: 296 LAEKTCVRKNENCYNTPGSYVCVCPDGFE 324
+ C C NT GS+ CVCP GF+
Sbjct: 758 RSPPPCT--YGRCENTEGSFQCVCPMGFQ 784
Score = 67.0 bits (162), Expect = 2e-11
Identities = 45/134 (33%), Positives = 60/134 (44%), Gaps = 28/134 (20%)
Query: 217 CEVGWVLDEGA--CVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNC 274
C+ G+ L C+DVDEC PPPC+ + C+N+ GS+ C C GPG
Sbjct: 572 CDSGFRLSPQGTRCIDVDECRRVPPPCAPGR-CENSPGSFRCV--------C---GPG-- 617
Query: 275 KECISGYAREHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFEETEDACVPPA 334
+C DVDEC C C NTPGS++CVCP G++ P
Sbjct: 618 ----FRAGPRAAECLDVDECHRVPPPC--DLGRCENTPGSFLCVCPAGYQ------AAPH 665
Query: 335 EAEATEGESPTQLP 348
A + + TQ P
Sbjct: 666 GASCQDVDECTQSP 679
Score = 57.8 bits (138), Expect = 1e-08
Identities = 34/105 (32%), Positives = 51/105 (48%), Gaps = 10/105 (9%)
Query: 233 ECAAEPPPCSAAQFCKN----ANGSYTCEECDSSCVGCTGEGPGNCKECISGYAREHGQC 288
ECA+ P + C A G + C+ C S +G + C +G+ R +G C
Sbjct: 297 ECASPLPGLRTQEVCCRGAGLAWGVHDCQLC-SERLGNSERVSAPDGPCPTGFERVNGSC 355
Query: 289 ADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGF--EETEDACV 331
DVDEC+ + ++ C NT G Y CVCPDGF + + +C+
Sbjct: 356 EDVDECATGGRC---QHGECANTRGGYTCVCPDGFLLDSSRSSCI 397
Score = 42.7 bits (99), Expect = 5e-04
Identities = 30/87 (34%), Positives = 36/87 (41%), Gaps = 13/87 (14%)
Query: 257 EECD--SSCVG--CTGEGPGNCKECISGYAREHGQ--CADVDECSLAEKT---CVRKNEN 307
EEC C C G C GY + + C D++EC AE CV N
Sbjct: 1535 EECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCV--NAR 1592
Query: 308 CYNTPGSYVCVCPDGFEETEDA--CVP 332
C NT GS+ C+C GF T C P
Sbjct: 1593 CLNTDGSFRCICRPGFAPTHQPHHCAP 1619
Score = 40.4 bits (93), Expect = 0.002
Identities = 21/56 (37%), Positives = 26/56 (46%), Gaps = 4/56 (7%)
Query: 266 CTGEGPGNCKECISGYA--REHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCVC 319
C PG C +GY + +C D DEC+ E C + C NT GSY C C
Sbjct: 1270 CVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPAC--EGGRCVNTVGSYHCTC 1323
Score = 38.9 bits (89), Expect = 0.007
Identities = 28/89 (31%), Positives = 35/89 (39%), Gaps = 13/89 (14%)
Query: 196 CTACDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDECAAEPPPCSAAQFCKNANGSYT 255
C C E ++ D G C G+ G+C DVDECA C + C N G YT
Sbjct: 324 CQLCSERLGNSERVSAPD-GPCPTGFERVNGSCEDVDECAT-GGRCQHGE-CANTRGGYT 380
Query: 256 C--------EECDSSCVG--CTGEGPGNC 274
C + SSC+ E G C
Sbjct: 381 CVCPDGFLLDSSRSSCISQHVISEAKGPC 409
Score = 35.4 bits (80), Expect = 0.078
Identities = 36/135 (26%), Positives = 46/135 (34%), Gaps = 25/135 (18%)
Query: 127 CCSPGT-YGPDCLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDCMDGYF 185
CC+ G +G C Q C G + + C GY P
Sbjct: 1207 CCTVGEGWGSGCRIQQ------------CPGTETAEYQSLCPHGRGYLAPSGD------- 1247
Query: 186 SSLRNETHSICTACDESCKT--CSGLTNRDCGECEVGWVLDEGA--CVDVDECAAEPPPC 241
SLR + D+ CK+ C C G+ C+D DECA E P C
Sbjct: 1248 LSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPAC 1307
Query: 242 SAAQFCKNANGSYTC 256
+ C N GSY C
Sbjct: 1308 EGGR-CVNTVGSYHC 1321
Score = 33.9 bits (76), Expect = 0.23
Identities = 25/69 (36%), Positives = 31/69 (44%), Gaps = 14/69 (20%)
Query: 201 ESCKTCSGLTNRDCGE--------CEVGWVLD--EGACVDVDEC---AAEPPPCSAAQFC 247
E C G TN C C G+ LD ACVD++EC A P C A+ C
Sbjct: 1535 EECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR-C 1593
Query: 248 KNANGSYTC 256
N +GS+ C
Sbjct: 1594 LNTDGSFRC 1602
Score = 31.2 bits (69), Expect = 1.5
Identities = 18/48 (37%), Positives = 24/48 (50%), Gaps = 6/48 (12%)
Query: 280 GYAREHGQCA---DVDECSL-AEKTCVRKNENCYNTPGSYVCVCPDGF 323
GY G + DVDEC L ++ C K+ C NT Y C C +G+
Sbjct: 1240 GYLAPSGDLSLRRDVDECQLFRDQVC--KSGVCVNTAPGYSCYCSNGY 1285
>gi|24430141 fibrillin 1 precursor [Homo sapiens]
Length = 2871
Score = 87.8 bits (216), Expect = 1e-17
Identities = 64/193 (33%), Positives = 77/193 (39%), Gaps = 42/193 (21%)
Query: 161 QGDGSCRCHMGYQGPL----CTDCMDGYFSSLRNETHSICTACDESCKTCSGLTNRDCGE 216
+G C C MGY G CTD + + H++CT S K CS
Sbjct: 1300 KGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFK-CS--------- 1349
Query: 217 CEVGWVLDEGACVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKE 276
C GW+ D C D+DEC+ CS CKN GSY C CKE
Sbjct: 1350 CSPGWIGDGIKCTDLDECSNGTHMCSQHADCKNTMGSYRC----------------LCKE 1393
Query: 277 CISGYAREHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFEETEDACVPPAEA 336
GY + C D+DECS C N C N PG Y C C GF VP A+
Sbjct: 1394 ---GYTGDGFTCTDLDECSENLNLC--GNGQCLNAPGGYRCECDMGF-------VPSADG 1441
Query: 337 EATEGESPTQLPS 349
+A E LP+
Sbjct: 1442 KACEDIDECSLPN 1454
Score = 81.6 bits (200), Expect = 9e-16
Identities = 72/228 (31%), Positives = 89/228 (39%), Gaps = 64/228 (28%)
Query: 123 TLKVCCSPGTYGP-----DCLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLC 177
+ K CSPG G D C G+ CS + C + G C C GY G
Sbjct: 1345 SFKCSCSPGWIGDGIKCTDLDECSNGTHM-CSQHADCK---NTMGSYRCLCKEGYTG--- 1397
Query: 178 TDCMDGYFSSLRNETHSICTACDESCKTCSGLTNRDC--------GECEVGWV--LDEGA 227
DG+ CT DE + + N C EC++G+V D A
Sbjct: 1398 ----DGF----------TCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKA 1443
Query: 228 CVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGYA--REH 285
C D+DEC+ P C N G + CE C GY R
Sbjct: 1444 CEDIDECSL--PNICVFGTCHNLPGLFRCE-------------------CEIGYELDRSG 1482
Query: 286 GQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFE--ETEDACV 331
G C DV+EC L TC+ + NC NTPGSY+C CP FE T CV
Sbjct: 1483 GNCTDVNEC-LDPTTCI--SGNCVNTPGSYICDCPPDFELNPTRVGCV 1527
Score = 77.0 bits (188), Expect = 2e-14
Identities = 54/181 (29%), Positives = 79/181 (43%), Gaps = 34/181 (18%)
Query: 145 QRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDCMDGYFSSLRNETHSICTACDESCK 204
+R GNG C + G +CRC+ G+ DC+D + ++C + C
Sbjct: 1896 ERDACGNGTCR---NTIGSFNCRCNHGFILSHNNDCID--VDECASGNGNLCR--NGQCI 1948
Query: 205 TCSGLTNRDCGECEVGWVL--DEGACVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSS 262
G C E G+ + D CVD++EC EP C A C+N +GSY C
Sbjct: 1949 NTVGSFQCQCNE---GYEVAPDGRTCVDINECLLEPRKC-APGTCQNLDGSYRC------ 1998
Query: 263 CVGCTGEGPGNCKECISGYAREHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDG 322
C GY+ ++ +C D+DEC + C C NT GS+ C+CP+G
Sbjct: 1999 -------------ICPPGYSLQNEKCEDIDECVEEPEICAL--GTCSNTEGSFKCLCPEG 2043
Query: 323 F 323
F
Sbjct: 2044 F 2044
Score = 73.9 bits (180), Expect = 2e-13
Identities = 60/223 (26%), Positives = 86/223 (38%), Gaps = 45/223 (20%)
Query: 129 SPGTYGPDCLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGY----QGPLCTDCMDGY 184
+P G C+ +Q P N C + +G C C GY G C D
Sbjct: 2434 TPDITGTSCVDLNECNQAPKPCNFICK---NTEGSYQCSCPKGYILQEDGRSCKD----- 2485
Query: 185 FSSLRNETHSICTACDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDECAAEPPPCSAA 244
+ H+ C T G T + C G+ +C+D +EC ++ C +
Sbjct: 2486 LDECATKQHNCQFLC---VNTIGGFTCK----CPPGFTQHHTSCIDNNECTSDINLCGSK 2538
Query: 245 QFCKNANGSYTCE--------ECDSSCV-------------GCTGEGPGNCKECISGYAR 283
C+N GS+TCE + SSC GC G C GY +
Sbjct: 2539 GICQNTPGSFTCECQRGFSLDQTGSSCEDVDECEGNHRCQHGCQNIIGGYRCSCPQGYLQ 2598
Query: 284 EH--GQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFE 324
+ QC D +EC A + +C+NT GSY C+CP GF+
Sbjct: 2599 HYQWNQCVDENECLSAH---ICGGASCHNTLGSYKCMCPAGFQ 2638
Score = 70.9 bits (172), Expect = 2e-12
Identities = 44/116 (37%), Positives = 54/116 (46%), Gaps = 27/116 (23%)
Query: 216 ECEVGWVLD-EGACVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNC 274
EC G+ LD G C+DVDEC E PC+ + C N GSYTC+
Sbjct: 475 ECNKGFQLDLRGECIDVDEC--EKNPCAGGE-CINNQGSYTCQ----------------- 514
Query: 275 KECISGYARE--HGQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFEETED 328
C +GY +C D+DEC + C N C NT GS+ CVC GF T D
Sbjct: 515 --CRAGYQSTLTRTECRDIDECLQNGRIC--NNGRCINTDGSFHCVCNAGFHVTRD 566
Score = 70.1 bits (170), Expect = 3e-12
Identities = 69/256 (26%), Positives = 91/256 (35%), Gaps = 62/256 (24%)
Query: 127 CCSPGTYGPDCLACQGG------SQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCT-D 179
C + G+ D CQ G Q C C G C C G+ GP C D
Sbjct: 123 CMNGGSCSDDHCLCQKGYIGTHCGQPVCESG--CLNGGRCVAPNRCACTYGFTGPQCERD 180
Query: 180 CMDG-YFSSLRNE-----------THSICTAC-----DESCKTCSGLTNRDCGECEVGWV 222
G F+ + N+ T ++C A C+ C + C G++
Sbjct: 181 YRTGPCFTVISNQMCQGQLSGIVCTKTLCCATVGRAWGHPCEMCPAQPH----PCRRGFI 236
Query: 223 --LDEGACVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISG 280
+ GAC DVDEC A P C C N GS+ C+ C +G
Sbjct: 237 PNIRTGACQDVDECQAIPGLCQGGN-CINTVGSFECK-------------------CPAG 276
Query: 281 YAREH--GQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFEETEDA--CVPP--- 333
+ +C D+DECS C + C NT SY C CP GF + D C+
Sbjct: 277 HKLNEVSQKCEDIDECSTIPGIC--EGGECTNTVSSYFCKCPPGFYTSPDGTRCIDVRPG 334
Query: 334 -AEAEATEGESPTQLP 348
T G QLP
Sbjct: 335 YCYTALTNGRCSNQLP 350
Score = 70.1 bits (170), Expect = 3e-12
Identities = 69/213 (32%), Positives = 87/213 (40%), Gaps = 48/213 (22%)
Query: 134 GPDCL---ACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQ-GPLCTDCMDGYFSSLR 189
G +C+ C G+ PC GNG C + G C C G++ GP+ T C D
Sbjct: 2161 GNECVDTDECSVGN--PC-GNGTCK---NVIGGFECTCEEGFEPGPMMT-CED------I 2207
Query: 190 NETHSICTACDESCKTCSGLTNRDCGECEVGWVL--DEGACVDVDECAAEPPPCSAAQF- 246
NE C C G + +C +C VG+VL D C D DEC C+ Q
Sbjct: 2208 NECAQNPLLCAFRCVNTYG--SYEC-KCPVGYVLREDRRMCKDEDECEEGKHDCTEKQME 2264
Query: 247 CKNANGSYTCEECDSSCVGCTGEGPGNCKECISGYARE-HGQ-CADVDECSLAEKTCVRK 304
CKN G+Y C C GY R G+ C D +EC C +
Sbjct: 2265 CKNLIGTYMCI-------------------CGPGYQRRPDGEGCVDENECQTKPGIC--E 2303
Query: 305 NENCYNTPGSYVCVCPDGF--EETEDACVPPAE 335
N C NT GSY C C DGF +D C+ E
Sbjct: 2304 NGRCLNTRGSYTCECNDGFTASPNQDECLDNRE 2336
Score = 68.9 bits (167), Expect = 6e-12
Identities = 76/289 (26%), Positives = 98/289 (33%), Gaps = 72/289 (24%)
Query: 120 CVKTLKVC----CSPGTYGPDCLACQG----GSQRPCSG-----------NGHCSGDGSR 160
CV+ ++C CS CL +G S R C G CS SR
Sbjct: 2017 CVEEPEICALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSR 2076
Query: 161 Q-GDGSCRCHMGYQG-----PLCTDCMDGYFSSLRNETHSICTACDES------CKTCSG 208
C C + +G LC D F + I D+S CK
Sbjct: 2077 NHSKQECCCALKGEGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDDSAVDMDECKEPDV 2136
Query: 209 LTNRDC--------GECEVGWVLDEGACVDVDECAAEPPPCSAAQFCKNANGSY--TCEE 258
+ C EC G++L CVD DEC+ P + CKN G + TCEE
Sbjct: 2137 CKHGQCINTDGSYRCECPFGYILAGNECVDTDECSVGNPCGNGT--CKNVIGGFECTCEE 2194
Query: 259 ----------------------CDSSCVGCTGEGPGNCKECISGYA--REHGQCADVDEC 294
C CV G CK C GY + C D DEC
Sbjct: 2195 GFEPGPMMTCEDINECAQNPLLCAFRCVNTYGSY--ECK-CPVGYVLREDRRMCKDEDEC 2251
Query: 295 SLAEKTCVRKNENCYNTPGSYVCVCPDGFEETED--ACVPPAEAEATEG 341
+ C K C N G+Y+C+C G++ D CV E + G
Sbjct: 2252 EEGKHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCVDENECQTKPG 2300
Score = 68.9 bits (167), Expect = 6e-12
Identities = 56/201 (27%), Positives = 77/201 (38%), Gaps = 34/201 (16%)
Query: 140 CQ-GGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTD--CMDGYFSSLRNETHSIC 196
CQ G S R C DG R C +QG + C G C
Sbjct: 2348 CQIGSSNRNPVTKSECCCDGGRGWGPHCEI-CPFQGTVAFKKLCPHGRGFMTNGADIDEC 2406
Query: 197 TACDESCKTCSGLTNRDCGEC--EVGWVLD--EGACVDVDECAAEPPPCSAAQFCKNANG 252
+ C+ + +R C + G+ D +CVD++EC P PC+ CKN G
Sbjct: 2407 KVIHDVCRNGECVNDRGSYHCICKTGYTPDITGTSCVDLNECNQAPKPCNF--ICKNTEG 2464
Query: 253 SYTCEECDSSCVGCTGEGPGNCKECISGYA-REHGQ-CADVDECSLAEKTCVRKNENCYN 310
SY C C GY +E G+ C D+DEC+ + C C N
Sbjct: 2465 SYQCS-------------------CPKGYILQEDGRSCKDLDECATKQHNC---QFLCVN 2502
Query: 311 TPGSYVCVCPDGFEETEDACV 331
T G + C CP GF + +C+
Sbjct: 2503 TIGGFTCKCPPGFTQHHTSCI 2523
Score = 67.8 bits (164), Expect = 1e-11
Identities = 62/230 (26%), Positives = 87/230 (37%), Gaps = 55/230 (23%)
Query: 123 TLKVCCSPG-TYGPDCLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCH------MGYQGP 175
+ K C PG D C+ ++ C G C DGS RC +G G
Sbjct: 593 SFKCICKPGFQLASDGRYCKDINE--CETPGICMNGRCVNTDGSYRCECFPGLAVGLDGR 650
Query: 176 LCTD------CMDGY---------FSSLRNETHSICTACD----ESCKTCSGLTNRDCGE 216
+C D C GY F ++ ++ C + + E C+ C + +
Sbjct: 651 VCVDTHMRSTCYGGYKRGQCIKPLFGAV-TKSECCCASTEYAFGEPCQPCPAQNSAEYQA 709
Query: 217 -CEVGWVLDEGACVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCK 275
C G + D++ECA +P C C+N G+Y C
Sbjct: 710 LCSSGPGMTSAGS-DINECALDPDICPNG-ICENLRGTYKCI------------------ 749
Query: 276 ECISGYAREHG--QCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGF 323
C SGY + C D++EC L C N C NTPGS+VC CP GF
Sbjct: 750 -CNSGYEVDSTGKNCVDINECVLNSLLC--DNGQCRNTPGSFVCTCPKGF 796
Score = 66.6 bits (161), Expect = 3e-11
Identities = 57/205 (27%), Positives = 83/205 (40%), Gaps = 42/205 (20%)
Query: 128 CSPG-TYGPDCLACQGGSQRPCSGNGHCSGDG---SRQGDGSCRCHMGYQG-PLCTDCMD 182
C PG P+ AC ++ C + H +G + G C C+ GY P C+D
Sbjct: 1140 CPPGHQLSPNISACIDINE--CELSAHLCPNGRCVNLIGKYQCACNPGYHSTPDRLFCVD 1197
Query: 183 GYFSSLRNETHSICTACDESCKTCSGLTNRDCGECEVGWVL--DEGACVDVDECAAEPPP 240
S+ N C+ C G + +C C+ G+ L D+ +C D+DEC P
Sbjct: 1198 IDECSIMNG------GCETFCTNSEG--SYECS-CQPGFALMPDQRSCTDIDECEDNPNI 1248
Query: 241 CSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGY--AREHGQCADVDECSLAE 298
C Q C N G Y C C G+ + + C DV+EC L
Sbjct: 1249 CDGGQ-CTNIPGEYRCL-------------------CYDGFMASEDMKTCVDVNECDLNP 1288
Query: 299 KTCVRKNENCYNTPGSYVCVCPDGF 323
C+ + C NT GS++C C G+
Sbjct: 1289 NICL--SGTCENTKGSFICHCDMGY 1311
Score = 65.5 bits (158), Expect = 7e-11
Identities = 62/224 (27%), Positives = 80/224 (35%), Gaps = 56/224 (25%)
Query: 150 GNGHCSGDGSRQGDGSCRCHMGYQG--PLCTDCMDGYFSSLRNETHSICTACDESCKTC- 206
G G C + GD C+C GY+ + +CMD C C
Sbjct: 1082 GRGQCV---NTPGDFECKCDEGYESGFMMMKNCMD-------------IDECQRDPLLCR 1125
Query: 207 SGLTNRDCG----ECEVGWVLDE--GACVDVDECAAEPPPCSAAQFCKNANGSYTC---- 256
G+ + G EC G L AC+D++EC C + C N G Y C
Sbjct: 1126 GGVCHNTEGSYRCECPPGHQLSPNISACIDINECELSAHLCPNGR-CVNLIGKYQCACNP 1184
Query: 257 --------------EECDSSCVGC-----TGEGPGNCKECISGYA--REHGQCADVDECS 295
+EC GC EG C C G+A + C D+DEC
Sbjct: 1185 GYHSTPDRLFCVDIDECSIMNGGCETFCTNSEGSYEC-SCQPGFALMPDQRSCTDIDECE 1243
Query: 296 LAEKTCVRKNENCYNTPGSYVCVCPDGFEETED--ACVPPAEAE 337
C C N PG Y C+C DGF +ED CV E +
Sbjct: 1244 DNPNIC--DGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECD 1285
Score = 63.5 bits (153), Expect = 3e-10
Identities = 48/160 (30%), Positives = 60/160 (37%), Gaps = 35/160 (21%)
Query: 217 CEVGWVLD--EGACVDVDECAAEPPPCSAAQFCKNANGSYTC------------------ 256
C+ G+ LD E C D+DEC P C Q C N G + C
Sbjct: 1055 CDSGFALDSEERNCTDIDECRISPDLCGRGQ-CVNTPGDFECKCDEGYESGFMMMKNCMD 1113
Query: 257 -EECDSSCVGCTG------EGPGNCKECISGY--AREHGQCADVDECSLAEKTCVRKNEN 307
+EC + C G EG C EC G+ + C D++EC L+ C N
Sbjct: 1114 IDECQRDPLLCRGGVCHNTEGSYRC-ECPPGHQLSPNISACIDINECELSAHLC--PNGR 1170
Query: 308 CYNTPGSYVCVCPDGFEETEDA--CVPPAEAEATEGESPT 345
C N G Y C C G+ T D CV E G T
Sbjct: 1171 CVNLIGKYQCACNPGYHSTPDRLFCVDIDECSIMNGGCET 1210
Score = 62.8 bits (151), Expect = 5e-10
Identities = 63/224 (28%), Positives = 81/224 (36%), Gaps = 71/224 (31%)
Query: 151 NGHCSGDGSRQGDGSCRCHMGYQ----GPLCTDCMDGYFSSLRNETHSICTACDESCKTC 206
NG C + +G C C+ GY+ G C D + +SL CD C
Sbjct: 736 NGICE---NLRGTYKCICNSGYEVDSTGKNCVDINECVLNSL---------LCDNG--QC 781
Query: 207 SGLTNRDCGECEVGWVL--DEGACVDVDECAAEPPPCSAAQFCKNANGSYTCE------- 257
C G++ D C D+DEC E PC CKN+ GS+ CE
Sbjct: 782 RNTPGSFVCTCPKGFIYKPDLKTCEDIDEC--ESSPCING-VCKNSPGSFICECSSESTL 838
Query: 258 ----------------------ECD---------SSCVGCTGEGPGN----CKE---CIS 279
C+ S C G G+ C+ C
Sbjct: 839 DPTKTICIETIKGTCWQTVIDGRCEININGATLKSQCCSSLGAAWGSPCTLCQVDPICGK 898
Query: 280 GYAREHG-QCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDG 322
GY+R G QC D+DEC + C KN C NT GS+ C CP G
Sbjct: 899 GYSRIKGTQCEDIDECEVFPGVC--KNGLCVNTRGSFKCQCPSG 940
Score = 61.6 bits (148), Expect = 1e-09
Identities = 52/188 (27%), Positives = 74/188 (39%), Gaps = 40/188 (21%)
Query: 162 GDGSCRCHMGYQGPLCTDCMDGYFSSLRNETHSICTACDESCKTCSGLTNRDCGECEVGW 221
G +C+C G+ T C+D NE S C S C EC+ G+
Sbjct: 2505 GGFTCKCPPGFTQHH-TSCIDN------NECTSDINLCG-SKGICQNTPGSFTCECQRGF 2556
Query: 222 VLDE--GACVDVDECAAEPPPCSAAQFCKNANGSYTCE------------EC--DSSCVG 265
LD+ +C DVDEC C+N G Y C +C ++ C+
Sbjct: 2557 SLDQTGSSCEDVDECEGNH---RCQHGCQNIIGGYRCSCPQGYLQHYQWNQCVDENECLS 2613
Query: 266 CTGEGPGNCKE--------CISGYAREH--GQCADVDECSLAEKTCVRKNENCYNTPGSY 315
G +C C +G+ E G C D++EC A+ C + C NT G Y
Sbjct: 2614 AHICGGASCHNTLGSYKCMCPAGFQYEQFSGGCQDINECGSAQAPC---SYGCSNTEGGY 2670
Query: 316 VCVCPDGF 323
+C CP G+
Sbjct: 2671 LCGCPPGY 2678
Score = 60.5 bits (145), Expect = 2e-09
Identities = 68/268 (25%), Positives = 89/268 (33%), Gaps = 85/268 (31%)
Query: 132 TYGPDCL---ACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQ----GPLCTDCMDGY 184
++ DC+ C G+ C NG C + G C+C+ GY+ G C D +
Sbjct: 1923 SHNNDCIDVDECASGNGNLCR-NGQCI---NTVGSFQCQCNEGYEVAPDGRTCVDINE-- 1976
Query: 185 FSSLRNETHSICTACDESCK--TCSGLTNRDCGECEVGWVLDEGACVDVDECAAEPPPCS 242
C C TC L C G+ L C D+DEC EP C
Sbjct: 1977 -----------CLLEPRKCAPGTCQNLDGSYRCICPPGYSLQNEKCEDIDECVEEPEIC- 2024
Query: 243 AAQFCKNANGSYTC-----------------------------EECDS----------SC 263
A C N GS+ C +C S C
Sbjct: 2025 ALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECC 2084
Query: 264 VGCTGEGPGN-CKEC----------ISGYAR-----EHGQCADVDECSLAEKTCVRKNEN 307
GEG G+ C+ C I Y D+DEC ++ V K+
Sbjct: 2085 CALKGEGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDDSAVDMDEC---KEPDVCKHGQ 2141
Query: 308 CYNTPGSYVCVCPDGFEETEDACVPPAE 335
C NT GSY C CP G+ + CV E
Sbjct: 2142 CINTDGSYRCECPFGYILAGNECVDTDE 2169
Score = 58.9 bits (141), Expect = 7e-09
Identities = 69/262 (26%), Positives = 97/262 (37%), Gaps = 70/262 (26%)
Query: 128 CSPGTY-GPDCLACQGGSQRPCSGNGHCSGDGS---RQGDGSCRCHMGYQ----GPLCTD 179
C G Y D C ++ C G C G G+ G+ +C C Y G C D
Sbjct: 1633 CPTGYYLNEDTRVCDDVNE--CETPGIC-GPGTCYNTVGNYTCICPPDYMQVNGGNNCMD 1689
Query: 180 -----CMDGYFSS--------LRNETHSICT-------ACDESCKTCSGLTNRD----CG 215
C Y++ L N T +C A ++ C+ C + + CG
Sbjct: 1690 MRRSLCYRNYYADNQTCDGELLFNMTKKMCCCSYNIGRAWNKPCEQCPIPSTDEFATLCG 1749
Query: 216 ECEVGWVLD--EGACVDVDECAAEPPPCSAAQFCKNANGSYTCE---------------- 257
G+V+D G VD+DEC P C C N GS+ CE
Sbjct: 1750 SQRPGFVIDIYTGLPVDIDECREIPGVCENG-VCINMVGSFRCECPVGFFYNDKLLVCED 1808
Query: 258 --EC--------DSSCVGCTGEGPGNCKECISGYA-REHGQCADVDECSLAEKTCVRKNE 306
EC ++ C+ G +CK GY GQC D +EC C +
Sbjct: 1809 IDECQNGPVCQRNAECINTAGSYRCDCKP---GYRFTSTGQCNDRNECQEIPNIC--SHG 1863
Query: 307 NCYNTPGSYVCVCPDGFEETED 328
C +T GS+ C+C GF+ +D
Sbjct: 1864 QCIDTVGSFYCLCHTGFKTNDD 1885
Score = 58.2 bits (139), Expect = 1e-08
Identities = 62/232 (26%), Positives = 81/232 (34%), Gaps = 48/232 (20%)
Query: 127 CCSPGTYGPDCLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDCMDGYFS 186
CC P GG+Q H GDG C C G P C +
Sbjct: 67 CC------PGWKTLPGGNQCIVPICRHSCGDGFCSRPNMCTCPSGQIAPSCGSRSIQH-C 119
Query: 187 SLRNETHSICTACDESCKTCSGLTNRDCGE--CEVGWVLDEGACVDVDECAAE----PPP 240
++R C+ D+ C G CG+ CE G L+ G CV + CA P
Sbjct: 120 NIRCMNGGSCS--DDHCLCQKGYIGTHCGQPVCESG-CLNGGRCVAPNRCACTYGFTGPQ 176
Query: 241 CS------------AAQFCKNANGSYTCEECDSSCVGCTGEGPGN-CKECISGYAREH-- 285
C + Q C+ C + + C G G+ C+ C A+ H
Sbjct: 177 CERDYRTGPCFTVISNQMCQGQLSGIVCTK--TLCCATVGRAWGHPCEMCP---AQPHPC 231
Query: 286 ----------GQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFEETE 327
G C DVDEC C + NC NT GS+ C CP G + E
Sbjct: 232 RRGFIPNIRTGACQDVDECQAIPGLC--QGGNCINTVGSFECKCPAGHKLNE 281
Score = 56.6 bits (135), Expect = 3e-08
Identities = 48/185 (25%), Positives = 73/185 (39%), Gaps = 46/185 (24%)
Query: 151 NGHCSGDGSRQGDGSCRCHMGYQGPLCTDCMDGYFSSLRNETHSICTACDES-CKTCSGL 209
NG C G C C+ G+Q L +C+D C+++ C +
Sbjct: 462 NGRCI---PTPGSCRCECNKGFQLDLRGECID-------------VDECEKNPCAGGECI 505
Query: 210 TNRD--CGECEVGW--VLDEGACVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVG 265
N+ +C G+ L C D+DEC C+ + C N +GS+ C
Sbjct: 506 NNQGSYTCQCRAGYQSTLTRTECRDIDECLQNGRICNNGR-CINTDGSFHC--------- 555
Query: 266 CTGEGPGNCKECISGY--AREHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGF 323
C +G+ R+ C D+DECS+ C+ N C N GS+ C+C GF
Sbjct: 556 ----------VCNAGFHVTRDGKNCEDMDECSI-RNMCL--NGMCINEDGSFKCICKPGF 602
Query: 324 EETED 328
+ D
Sbjct: 603 QLASD 607
Score = 55.8 bits (133), Expect = 6e-08
Identities = 31/97 (31%), Positives = 44/97 (45%), Gaps = 24/97 (24%)
Query: 230 DVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGYA--REHGQ 287
D++EC P C+ + C+N GS+ C C SG+A E
Sbjct: 1028 DINECKMIPSLCTHGK-CRNTIGSFKCR-------------------CDSGFALDSEERN 1067
Query: 288 CADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFE 324
C D+DEC ++ C R C NTPG + C C +G+E
Sbjct: 1068 CTDIDECRISPDLCGRGQ--CVNTPGDFECKCDEGYE 1102
Score = 54.3 bits (129), Expect = 2e-07
Identities = 66/279 (23%), Positives = 91/279 (32%), Gaps = 100/279 (35%)
Query: 136 DCLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPL----CTD----------CM 181
+C+ + PC+G G C + QG +C+C GYQ L C D C
Sbjct: 487 ECIDVDECEKNPCAG-GECINN---QGSYTCQCRAGYQSTLTRTECRDIDECLQNGRICN 542
Query: 182 DGYFSSLRNETHSICTA----------CD--ESCKTCSGLTNRDCGE--------CEVGW 221
+G + H +C A C+ + C + N C C+ G+
Sbjct: 543 NGRCINTDGSFHCVCNAGFHVTRDGKNCEDMDECSIRNMCLNGMCINEDGSFKCICKPGF 602
Query: 222 VL--DEGACVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGE---GPGNCKE 276
L D C D++EC E P C N +GSY CE VG G
Sbjct: 603 QLASDGRYCKDINEC--ETPGICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRST 660
Query: 277 CISGYAREHGQC------------------------------------------------ 288
C GY R GQC
Sbjct: 661 CYGGYKR--GQCIKPLFGAVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMT 718
Query: 289 ---ADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFE 324
+D++EC+L C N C N G+Y C+C G+E
Sbjct: 719 SAGSDINECALDPDIC--PNGICENLRGTYKCICNSGYE 755
Score = 46.6 bits (109), Expect = 3e-05
Identities = 43/160 (26%), Positives = 58/160 (36%), Gaps = 33/160 (20%)
Query: 190 NETHSICTACDESCKTCSGLTNRDCGECEVGWVLDEG--ACVDVDECAAEPPPCSAAQFC 247
+E I C+ C + EC VG+ ++ C D+DEC P C C
Sbjct: 1768 DECREIPGVCENG--VCINMVGSFRCECPVGFFYNDKLLVCEDIDECQ-NGPVCQRNAEC 1824
Query: 248 KNANGSYTCEECDSSCVGCTGE--------------GPGNCKE--------CISGYAREH 285
N GSY C+ TG+ G C + C +G+
Sbjct: 1825 INTAGSYRCDCKPGYRFTSTGQCNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTND 1884
Query: 286 GQ--CADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGF 323
Q C D++EC C N C NT GS+ C C GF
Sbjct: 1885 DQTMCLDINECE--RDAC--GNGTCRNTIGSFNCRCNHGF 1920
Score = 45.1 bits (105), Expect = 1e-04
Identities = 29/96 (30%), Positives = 38/96 (39%), Gaps = 25/96 (26%)
Query: 230 DVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGYAREHGQ-- 287
D+DEC P C + C N GS+ C C +GY
Sbjct: 1606 DIDECQELPGLCQGGK-CINTFGSFQCR-------------------CPTGYYLNEDTRV 1645
Query: 288 CADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGF 323
C DV+EC E + CYNT G+Y C+CP +
Sbjct: 1646 CDDVNEC---ETPGICGPGTCYNTVGNYTCICPPDY 1678
Score = 31.2 bits (69), Expect = 1.5
Identities = 17/47 (36%), Positives = 21/47 (44%), Gaps = 3/47 (6%)
Query: 292 DECSLAEKTCVRKNENCYNTPGSYVCVCPDGFE-ETEDACVPPAEAE 337
D C L C +N C TPGS C C GF+ + C+ E E
Sbjct: 451 DYCQLVRYLC--QNGRCIPTPGSCRCECNKGFQLDLRGECIDVDECE 495
>gi|56237021 fibrillin 3 precursor [Homo sapiens]
Length = 2809
Score = 85.9 bits (211), Expect = 5e-17
Identities = 68/241 (28%), Positives = 93/241 (38%), Gaps = 55/241 (22%)
Query: 120 CVKTL---KVCCSPGTYGPD-----CLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMG 171
C+ +L + C G Y PD CL SQ P C + +G C C G
Sbjct: 2379 CINSLGSFRCHCQAG-YTPDATATTCLDMDECSQVPKPCTFLCK---NTKGSFLCSCPRG 2434
Query: 172 Y----QGPLCTDCMDGYFSSLRNETHSICTACDESCK-TCSGLTNRDCGECEVGWVLDEG 226
Y G C D + CT+ +C+ C C G+
Sbjct: 2435 YLLEEDGRTCKDLDE-------------CTSRQHNCQFLCVNTVGAFTCRCPPGFTQHHQ 2481
Query: 227 ACVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGYAREHG 286
AC D DEC+A+P PC A C N GS+ CE + +G G + EC + +HG
Sbjct: 2482 ACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHRCQHG 2541
Query: 287 -----------------------QCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGF 323
QC D +EC+L+ TC + +C NT G + CVCP GF
Sbjct: 2542 CQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTC--GSASCRNTLGGFRCVCPSGF 2599
Query: 324 E 324
+
Sbjct: 2600 D 2600
Score = 77.0 bits (188), Expect = 2e-14
Identities = 66/227 (29%), Positives = 82/227 (36%), Gaps = 46/227 (20%)
Query: 120 CVKTLKVC----CSPGTYGPDCLACQGGSQRP----------CSGNGHCSGDG---SRQG 162
C + +VC C+ G CL G P C N H G + +G
Sbjct: 1200 CEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKG 1259
Query: 163 DGSCRCHMGYQGPL-CTDCMDGYFSSLRNETHSICTACDESCKTCSGLTNRDCGECEVGW 221
C C +GY T C D + CD S +C + C GW
Sbjct: 1260 SFVCHCQLGYMVRKGATGCSDVDECEVGGHN------CD-SHASCLNIPGSFSCRCLPGW 1312
Query: 222 VLDEGACVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGY 281
V D C D+DEC ++ CS C N GSY C C G+
Sbjct: 1313 VGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRC-------------------TCRQGF 1353
Query: 282 AREHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFEETED 328
A + C D DEC AE + N C N PG Y C C GF+ TED
Sbjct: 1354 AGDGFFCEDRDEC--AENVDLCDNGQCLNAPGGYRCECEMGFDPTED 1398
Score = 77.0 bits (188), Expect = 2e-14
Identities = 67/226 (29%), Positives = 87/226 (38%), Gaps = 46/226 (20%)
Query: 127 CCSPGTYGPDCLACQ-----GGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDCM 181
C + Y LAC+ G + PC N C + G C+C GY+ C+
Sbjct: 1748 CPAGFNYNSILLACEDVDECGSRESPCQQNADCI---NIPGSYRCKCTRGYKLSPGGACV 1804
Query: 182 DGYFSSLRNETHSICTACDESCKTCSGLTNRDCGECEVGWVL--DEGACVDVDECAAEPP 239
RNE I C C C G+ D+ C+D+DEC +P
Sbjct: 1805 G------RNECREIPNVCSHG--DCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQP- 1855
Query: 240 PCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGYAREH-GQCADVDECS-LA 297
C CKN GSY C C G+ H G C D DEC+ L
Sbjct: 1856 -CGNGT-CKNIIGSYNCL-------------------CFPGFVVTHNGDCVDFDECTTLV 1894
Query: 298 EKTCVRKNENCYNTPGSYVCVCPDGFEETEDA--CVPPAEAEATEG 341
+ C + +C NT GS+ C+C DGFE T D CV E + G
Sbjct: 1895 GQVC--RFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAG 1938
Score = 74.3 bits (181), Expect = 2e-13
Identities = 70/255 (27%), Positives = 98/255 (38%), Gaps = 63/255 (24%)
Query: 117 EWFCVKTLKVC---CSPG-------TYGPDCLACQGGSQRPCSGNGHCSGDGSRQGDGSC 166
++ CV T+ C PG + D + Q G PC +GHC + G C
Sbjct: 2458 QFLCVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPG---PCGAHGHCH---NTPGSFRC 2511
Query: 167 RCHMGYQGPLCTDCMDGYFSSLRNETHSICTACDESCKTCSGLTNRDCG---ECEVGWVL 223
CH G+ T G+ NE CD + G N+ G C G+
Sbjct: 2512 ECHQGF-----TLVSSGHGCEDVNE-------CDGPHRCQHGCQNQLGGYRCSCPQGFTQ 2559
Query: 224 DE--GACVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGY 281
CVD +ECA PP C +A C+N G + C C SG+
Sbjct: 2560 HSQWAQCVDENECALSPPTCGSAS-CRNTLGGFRCV-------------------CPSGF 2599
Query: 282 AREH--GQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDG-FEETEDACVPPAEAEA 338
+ G C +VDEC+ C + +C NTPG ++C CP G F + CV +
Sbjct: 2600 DFDQALGGCQEVDECAGRRGPC---SYSCANTPGGFLCGCPQGYFRAGQGHCV----SGL 2652
Query: 339 TEGESPTQLPSREDL 353
P P +E+L
Sbjct: 2653 GFSPGPQDTPDKEEL 2667
Score = 73.9 bits (180), Expect = 2e-13
Identities = 64/206 (31%), Positives = 80/206 (38%), Gaps = 46/206 (22%)
Query: 128 CSPGTYGPDCLACQG-----GSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDCMD 182
C PG G D C + CS G C + G C C G+ G D
Sbjct: 1308 CLPGWVG-DGFECHDLDECVSQEHRCSPRGDCL---NVPGSYRCTCRQGFAG-------D 1356
Query: 183 GYFSSLRNETHSICTACDESCKTCSGLTNRDCGECEVGW--VLDEGACVDVDECAAEPPP 240
G+F R+E CD C ECE+G+ D AC DVDECA +
Sbjct: 1357 GFFCEDRDECAENVDLCDNG--QCLNAPGGYRCECEMGFDPTEDHRACQDVDECA-QGNL 1413
Query: 241 CSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGYA--REHGQCADVDECSLAE 298
C+ C+N G + C C GY R G C D++EC+
Sbjct: 1414 CAFGS-CENLPGMFRCI-------------------CNGGYELDRGGGNCTDINECA-DP 1452
Query: 299 KTCVRKNENCYNTPGSYVCVCPDGFE 324
C+ N C NTPGSY+C CP FE
Sbjct: 1453 VNCI--NGVCINTPGSYLCSCPQDFE 1476
Score = 70.5 bits (171), Expect = 2e-12
Identities = 42/129 (32%), Positives = 55/129 (42%), Gaps = 28/129 (21%)
Query: 217 CEVGWVLDEGA--CVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNC 274
C+ G+ D A C+D+DEC+ P PC+ CKN GS+ C
Sbjct: 2390 CQAGYTPDATATTCLDMDECSQVPKPCTF--LCKNTKGSFLCS----------------- 2430
Query: 275 KECISGYAREHG--QCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFEETEDACVP 332
C GY E C D+DEC+ + C C NT G++ C CP GF + AC
Sbjct: 2431 --CPRGYLLEEDGRTCKDLDECTSRQHNC---QFLCVNTVGAFTCRCPPGFTQHHQACFD 2485
Query: 333 PAEAEATEG 341
E A G
Sbjct: 2486 NDECSAQPG 2494
Score = 68.2 bits (165), Expect = 1e-11
Identities = 72/253 (28%), Positives = 93/253 (36%), Gaps = 61/253 (24%)
Query: 132 TYGPDCLACQGG-----SQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDCMDGY-- 184
T G AC GG +R C+ C G G+C + G +C GY
Sbjct: 1005 TVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTC---VNTPGSFECECFPGYES 1061
Query: 185 -FSSLRNETHSICTACDESCKT---CSG--LTNRDCG---ECEVGWVLDEG--ACVDVDE 233
F ++N C DE + C G TN D +C G L AC D+DE
Sbjct: 1062 GFMLMKN-----CMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDE 1116
Query: 234 CAAEPPPCSAAQFCKNANGSYTCE-------------------------ECDSSCVGCTG 268
C+ C Q C N G++ C CD C+
Sbjct: 1117 CSLSDGLCPHGQ-CVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINT-- 1173
Query: 269 EGPGNCKECISGYAR--EHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFEET 326
EG C C GY+ + CADVDEC + C +C N PG + C+C DGF T
Sbjct: 1174 EGSYRCS-CGQGYSLMPDGRACADVDECEENPRVC--DQGHCTNMPGGHRCLCYDGFMAT 1230
Query: 327 ED--ACVPPAEAE 337
D CV E +
Sbjct: 1231 PDMRTCVDVDECD 1243
Score = 66.6 bits (161), Expect = 3e-11
Identities = 44/136 (32%), Positives = 59/136 (43%), Gaps = 27/136 (19%)
Query: 230 DVDECAAEPPPCSAAQFCKNANGSYTCE-----ECDSSCVGCTGE---------GPGNCK 275
DV+ECA P C+ C N +GS+ CE D + + C G G C
Sbjct: 2084 DVNECAENPGVCTNG-VCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCT 2142
Query: 276 ECISGY------AREHG---QCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFEET 326
I G+ E G C D+DECSL C + C+NT GSY+C CP G+
Sbjct: 2143 NVIGGFECACADGFEPGLMMTCEDIDECSLNPLLCAFR---CHNTEGSYLCTCPAGYTLR 2199
Query: 327 EDACVPPAEAEATEGE 342
ED + E +G+
Sbjct: 2200 EDGAMCRDVDECADGQ 2215
Score = 65.1 bits (157), Expect = 9e-11
Identities = 69/236 (29%), Positives = 90/236 (38%), Gaps = 72/236 (30%)
Query: 125 KVCCS--PGT-YGPDCLAC-QGGS---QRPCS-GNGHCSG-DGSRQGDGSCRCHMGYQGP 175
+ CCS PG +G C C Q GS Q C G+G G D SR+ C + G
Sbjct: 2038 RCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPG---- 2093
Query: 176 LCTD--CM--DGYFSSLRNETHSICTACDESCKTCSGLTNRDCGECEVGWVLDEGACV-- 229
+CT+ C+ DG F C +G+ D EC VG +G C
Sbjct: 2094 VCTNGVCVNTDGSFR---------CECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNV 2144
Query: 230 ---------------------DVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTG 268
D+DEC+ P C+ C N GSY C
Sbjct: 2145 IGGFECACADGFEPGLMMTCEDIDECSLNPLLCAFR--CHNTEGSYLCT----------- 2191
Query: 269 EGPGNCKECISGYA-REHG-QCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDG 322
C +GY RE G C DVDEC+ ++ C + C N G++ CVCP G
Sbjct: 2192 --------CPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPG 2239
Score = 64.7 bits (156), Expect = 1e-10
Identities = 62/207 (29%), Positives = 82/207 (39%), Gaps = 59/207 (28%)
Query: 151 NGHCSGDGSRQGDGSCRC----HMGYQGPLCTD------CMDGY--------FSSLRNET 192
NGHC+ + +G C+C +G G +C D C F ++
Sbjct: 584 NGHCT---NTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKS 640
Query: 193 HSICTACD----ESCKTCSGLTNRDCGE----CEVGW-VLDEGACVDVDECAAEPPPCSA 243
C D E C+ C +D E C G + +G D++ECA +P C A
Sbjct: 641 ECCCANPDHGFGEPCQLCPA---KDSAEFQALCSSGLGITTDGR--DINECALDPEVC-A 694
Query: 244 AQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGY-AREHGQ-CADVDECSLAEKTC 301
C+N GSY C C GY A G+ C DVDEC+L C
Sbjct: 695 NGVCENLRGSYRCV-------------------CNLGYEAGASGKDCTDVDECALNSLLC 735
Query: 302 VRKNENCYNTPGSYVCVCPDGFEETED 328
N C N+PGSY C CP GF +D
Sbjct: 736 --DNGWCQNSPGSYSCSCPPGFHFWQD 760
Score = 63.2 bits (152), Expect = 3e-10
Identities = 61/223 (27%), Positives = 78/223 (34%), Gaps = 69/223 (30%)
Query: 151 NGHCSGDGSRQGDGSCRCHMGYQ----GPLCTDCMDGYFSSLRNETHSICTACDES-CKT 205
NG C + +G C C++GY+ G CTD + +SL CD C+
Sbjct: 695 NGVCE---NLRGSYRCVCNLGYEAGASGKDCTDVDECALNSL---------LCDNGWCQN 742
Query: 206 CSGLTNRDCGECEVGWVLDEGACVDVDECAAEPPPCSAAQFCKNANGSYTCE-----ECD 260
G + C W D C DVDEC + P + C+N GSYTC+ D
Sbjct: 743 SPGSYSCSCPPGFHFWQ-DTEICKDVDECLSSP---CVSGVCRNLAGSYTCKCGPGSRLD 798
Query: 261 SSCVGCTGEGPGNC----------------------------------------KECISG 280
S C G C C G
Sbjct: 799 PSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCERCEIDPACARG 858
Query: 281 YAREHG-QCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDG 322
+AR G C DV+EC C N C NT GS+ C CP+G
Sbjct: 859 FARMTGVTCDDVNECESFPGVC--PNGRCVNTAGSFRCECPEG 899
Score = 60.8 bits (146), Expect = 2e-09
Identities = 46/144 (31%), Positives = 58/144 (40%), Gaps = 29/144 (20%)
Query: 190 NETHSICTACDESCKT--CSGLTNRDCGECEVGWVLD-EGACVDVDECAAEPPPCSAAQF 246
N+T IC C C + EC VG+ D G C+DVDEC + P C
Sbjct: 406 NQTIDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSP--CHHGD- 462
Query: 247 CKNANGSYTCEECDSSCVGCTGEGPGNCKECISGYAREHGQ--CADVDECSLAEKTCVRK 304
C N G+Y C C G+ + C DVDEC ++ C
Sbjct: 463 CVNIPGTYHCR-------------------CYPGFQATPTRQACVDVDECIVSGGLC--H 501
Query: 305 NENCYNTPGSYVCVCPDGFEETED 328
C NT GS+ CVC GFE + D
Sbjct: 502 LGRCVNTEGSFQCVCNAGFELSPD 525
Score = 60.1 bits (144), Expect = 3e-09
Identities = 53/179 (29%), Positives = 65/179 (36%), Gaps = 33/179 (18%)
Query: 152 GHCSGDGSRQ---GDGSCRCHMGYQGPLCTDCMDGYFSSLRNETHSICTACDESCKTCSG 208
GH G G+ G C C G++ L C D SL + E C+
Sbjct: 2133 GHPCGQGTCTNVIGGFECACADGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCT- 2191
Query: 209 LTNRDCGECEVGWVL--DEGACVDVDECAAEPPPCSAAQF-CKNANGSYTCEECDSSCVG 265
C G+ L D C DVDECA C A CKN G++ C C
Sbjct: 2192 --------CPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACV-CPPGMRP 2242
Query: 266 CTGEGPGNCKECISGYAREHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFE 324
G G G C D +EC CV N C NT GS+ C C +GF+
Sbjct: 2243 LPGSGEG---------------CTDDNECHAQPDLCV--NGRCVNTAGSFRCDCDEGFQ 2284
Score = 54.3 bits (129), Expect = 2e-07
Identities = 67/262 (25%), Positives = 84/262 (32%), Gaps = 55/262 (20%)
Query: 117 EWFCVKTLKVCCSPGTYGPDCLACQG-GSQRPCSGNGHCSG------------------- 156
E FC + C+ GT P C +G G C G C G
Sbjct: 92 EGFCSQPNLCTCADGTLAPSCGVSRGSGCSVSCMNGGTCRGASCLCQKGYTGTVCGQPIC 151
Query: 157 ------DGSRQGDGSCRCHMGYQGPLCT-DCMDG-YFSSLRNE------THSICTA--CD 200
G G C C G+ GP C D G F + E T +CT C
Sbjct: 152 DRGCHNGGRCIGPNRCACVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKALCC 211
Query: 201 ESCKTCSGLTNRDCGE----CEVGWV--LDEGACVDVDECAAEPPPCSAAQFCKNANGSY 254
+ GL C C G++ + GAC DVDEC A P C C N GS+
Sbjct: 212 ATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVPGLCQGGS-CVNMVGSF 270
Query: 255 TC-----EECDSSCVGCTGEGPGNCKECISGYAREHGQCADVDECSLAEKTCVRKNENCY 309
C S C G C + G G+CA + C C+
Sbjct: 271 HCRCPVGHRLSDSSAACEDYRAGACFSVLFG-----GRCAGDLAGHYTRRQCCCDRGRCW 325
Query: 310 NTPGSYVCVCPD-GFEETEDAC 330
G +CP G E + C
Sbjct: 326 -AAGPVPELCPPRGSNEFQQLC 346
Score = 53.5 bits (127), Expect = 3e-07
Identities = 59/207 (28%), Positives = 74/207 (35%), Gaps = 43/207 (20%)
Query: 151 NGHCSGDGSRQGDGSCRCHMGYQGPLCTDCMDGYFSSLRNETHSICTACDESCKTCSGLT 210
NG C S C C++GY + +C+D + T S C D C +
Sbjct: 421 NGRCLPTPSSY---RCECNVGYTQDVRGECID-----VDECTSSPCHHGD-----CVNIP 467
Query: 211 NRDCGECEVGW--VLDEGACVDVDECAAEPPPCSAAQFCKNANGSYTC------------ 256
C G+ ACVDVDEC C + C N GS+ C
Sbjct: 468 GTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGR-CVNTEGSFQCVCNAGFELSPDG 526
Query: 257 ------EECDSS--CVG--CTGEGPGNCKECISGYAREHG--QCADVDECSLAEKTCVRK 304
EC +S CV C E C G+ G C D+DEC CV
Sbjct: 527 KNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQ-TPGICV-- 583
Query: 305 NENCYNTPGSYVCVCPDGFEETEDACV 331
N +C NT GS+ C C G D V
Sbjct: 584 NGHCTNTEGSFRCQCLGGLAVGTDGRV 610
Score = 52.8 bits (125), Expect = 5e-07
Identities = 34/93 (36%), Positives = 39/93 (41%), Gaps = 24/93 (25%)
Query: 230 DVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGY-AREHGQ- 287
D+DEC P C C N GS+ CE C GY EH +
Sbjct: 1563 DIDECQELPGLCQGGD-CVNTFGSFQCE-------------------CPPGYHLSEHTRI 1602
Query: 288 CADVDECSLAEKTCVRKNENCYNTPGSYVCVCP 320
C D+DECS C CYNT G+Y CVCP
Sbjct: 1603 CEDIDECSTHSGIC--GPGTCYNTLGNYTCVCP 1633
Score = 50.8 bits (120), Expect = 2e-06
Identities = 63/267 (23%), Positives = 86/267 (32%), Gaps = 79/267 (29%)
Query: 130 PGTYGPDCLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDCMDGYFSSLR 189
PG+Y C G C C+ + +G C + G +C G+ +
Sbjct: 1342 PGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQC---LNAPGGYRCECEMGFDPT-- 1396
Query: 190 NETHSICTACDESCK-------TCSGLTNRDCGECEVGWVLDEGA--CVDVDECAAEPPP 240
E H C DE + +C L C G+ LD G C D++ECA +P
Sbjct: 1397 -EDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINECA-DPVN 1454
Query: 241 CSAAQFCKNANGSYTCE-----ECDSSCVGCT---------------------------- 267
C C N GSY C E + S VGC
Sbjct: 1455 CING-VCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVG 1513
Query: 268 ----------GEGPGN-CKECISGYAREHGQCA----------------DVDECSLAEKT 300
G GN C+ C E+ D+DEC
Sbjct: 1514 VTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGL 1573
Query: 301 CVRKNENCYNTPGSYVCVCPDGFEETE 327
C + +C NT GS+ C CP G+ +E
Sbjct: 1574 C--QGGDCVNTFGSFQCECPPGYHLSE 1598
Score = 50.4 bits (119), Expect = 2e-06
Identities = 66/262 (25%), Positives = 84/262 (32%), Gaps = 84/262 (32%)
Query: 128 CSPG---TYGPDCL---ACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQ----GPLC 177
C PG T+ DC+ C + C GHC G C C G++ G C
Sbjct: 1872 CFPGFVVTHNGDCVDFDECTTLVGQVCRF-GHCLNTA---GSFHCLCQDGFELTADGKNC 1927
Query: 178 TDCMDGYFSSLRNETHSICTACDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDECAAE 237
D NE S+ C TC L C G+ + C+D+DEC+ E
Sbjct: 1928 VDT---------NECLSLAGTCLPG--TCQNLEGSFRCICPPGFQVQSDHCIDIDECSEE 1976
Query: 238 PPPCSAAQFCKNANGSYTC----------------------------------------- 256
P C C N+ GS+ C
Sbjct: 1977 PNLCLFGT-CTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTT 2035
Query: 257 -----------EECDSSCVGCTGEGPGNCKE-CISGYAREHG---QCADVDECSLAEKTC 301
E C C EG +E C G+ G DV+EC AE
Sbjct: 2036 KTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNEC--AENPG 2093
Query: 302 VRKNENCYNTPGSYVCVCPDGF 323
V N C NT GS+ C CP G+
Sbjct: 2094 VCTNGVCVNTDGSFRCECPFGY 2115
Score = 47.8 bits (112), Expect = 2e-05
Identities = 63/267 (23%), Positives = 90/267 (33%), Gaps = 96/267 (35%)
Query: 128 CSPGTYG-PDCLACQGGSQRPCSGN----GHCSGDGSRQGDGSCRCHMGYQ-GPLCTDCM 181
C PG P AC + SG G C + +G C C+ G++ P +C+
Sbjct: 474 CYPGFQATPTRQACVDVDECIVSGGLCHLGRCV---NTEGSFQCVCNAGFELSPDGKNCV 530
Query: 182 DGYFSSLRNETHSICTACDESCKTCSGLTNRDCGE----CEVGWVLDEGA--CVDVDECA 235
D NE C S +G+ + G C+ G++L G C+D+DEC
Sbjct: 531 D------HNE-------CATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDEC- 576
Query: 236 AEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGYAR-------EHGQC 288
+ P C N GS+ C+ VG G + C+ + R E G C
Sbjct: 577 -QTPGICVNGHCTNTEGSFRCQCLGGLAVGTDG------RVCVDTHVRSTCYGAIEKGSC 629
Query: 289 A---------------------------------------------------DVDECSLA 297
A D++EC+L
Sbjct: 630 ARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGRDINECALD 689
Query: 298 EKTCVRKNENCYNTPGSYVCVCPDGFE 324
+ C N C N GSY CVC G+E
Sbjct: 690 PEVCA--NGVCENLRGSYRCVCNLGYE 714
Score = 38.5 bits (88), Expect = 0.009
Identities = 56/226 (24%), Positives = 78/226 (34%), Gaps = 32/226 (14%)
Query: 119 FCVKTLKVCCSPGTYGPDC-LACQGGSQRP--CSGNGHCSGDGSRQGDGSCRCHMGYQGP 175
FC+ + K C C + QG S R C+ G G + + C G+
Sbjct: 803 FCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCERCEIDPACARGFARM 862
Query: 176 LCTDCMDGYFSSLRNETHSICTACDES-CKTCSGLTNRDCGECEVGWVLDEGA--CVDV- 231
C D NE S C C +G +C E G +LD CVDV
Sbjct: 863 TGVTCDDV------NECESFPGVCPNGRCVNTAGSFRCECPE---GLMLDASGRLCVDVR 913
Query: 232 ----------DECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGY 281
DEC P C + G+ EC++ + E C +
Sbjct: 914 LEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFA 973
Query: 282 AREHGQ----CADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGF 323
+R+ DV+EC + C + C NT GS+ C C GF
Sbjct: 974 SRDFLSGRPFYKDVNECKVFPGLCT--HGTCRNTVGSFHCACAGGF 1017
>gi|66346695 fibrillin 2 precursor [Homo sapiens]
Length = 2912
Score = 84.3 bits (207), Expect = 1e-16
Identities = 72/244 (29%), Positives = 96/244 (39%), Gaps = 51/244 (20%)
Query: 116 FEWFCVKTLKVCCSPGTYGPDCLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGY--- 172
F FC KV + G C+ SQ P N C + +G C C GY
Sbjct: 2472 FRCFC----KVGYTTDISGTSCIDLDECSQSPKPCNYICK---NTEGSYQCSCPRGYVLQ 2524
Query: 173 -QGPLCTDCMDGYFSSLRNETHSICTACDESCKTCSGLTNRDCGECEVGWVLDEGACVDV 231
G C D + + H+ C T G T + C G+ AC+D
Sbjct: 2525 EDGKTCKD-----LDECQTKQHNCQFLC---VNTLGGFTCK----CPPGFTQHHTACIDN 2572
Query: 232 DECAAEPPPCSAAQFCKNANGSYTCE------------------ECDSS--CV-GCTGEG 270
+EC ++P C A C+N GS++CE ECD + C GC
Sbjct: 2573 NECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQNIL 2632
Query: 271 PGNCKECISGYAREH--GQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDG--FEET 326
G C GY + + QC D +ECS C + +CYNT GSY C CP G F++
Sbjct: 2633 GGYRCGCPQGYIQHYQWNQCVDENECS-NPNAC--GSASCYNTLGSYKCACPSGFSFDQF 2689
Query: 327 EDAC 330
AC
Sbjct: 2690 SSAC 2693
Score = 81.3 bits (199), Expect = 1e-15
Identities = 68/226 (30%), Positives = 88/226 (38%), Gaps = 48/226 (21%)
Query: 127 CCSPGTYGPDCLACQGG-----SQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCT-DC 180
C + GT D CQ G +P NG C G G C C G+ GP C D
Sbjct: 153 CMNGGTCADDHCQCQKGYIGTYCGQPVCENG-CQNGGRCIGPNRCACVYGFTGPQCERDY 211
Query: 181 MDG-YFSSLRNE------THSICTACDESCKTCSGLTNRDCGECEV-------GWV--LD 224
G F+ + N+ T +CT C T C C G++ +
Sbjct: 212 RTGPCFTQVNNQMCQGQLTGIVCTKT-LCCATIGRAWGHPCEMCPAQPQPCRRGFIPNIR 270
Query: 225 EGACVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGYARE 284
GAC DVDEC A P C C N GS+ C C +G+ +
Sbjct: 271 TGACQDVDECQAIPGICQGGN-CINTVGSFECR-------------------CPAGHKQS 310
Query: 285 HG--QCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFEETED 328
+C D+DECS+ C + C NT GSY CVCP G+ + D
Sbjct: 311 ETTQKCEDIDECSIIPGIC--ETGECSNTVGSYFCVCPRGYVTSTD 354
Score = 77.4 bits (189), Expect = 2e-14
Identities = 72/239 (30%), Positives = 94/239 (39%), Gaps = 50/239 (20%)
Query: 120 CVKTLKVCCSPGTYGPDCLACQGGSQRPCSGNGHC------------SGDGSRQGDGSCR 167
C+ L + PG+ G G P SGNG+ G+G G G
Sbjct: 417 CMDGLPMGGIPGSAGSRPGGTGGNGFAP-SGNGNGYGPGGTGFIPIPGGNGFSPGVGGAG 475
Query: 168 CHMGYQGPLCTDCMDGYFSSLRNETHSICTACDESCKT--CSGLTNRDCGECEVGWVLD- 224
G QGP+ T ++ N+T IC C C + EC +G+ D
Sbjct: 476 VGAGGQGPIITGL------TILNQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDA 529
Query: 225 EGACVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGYARE 284
G C+DVDEC + P C+ C N GSY C+ C +G+ R
Sbjct: 530 NGDCIDVDECTSNP--CTNGD-CVNTPGSYYCK-------------------CHAGFQRT 567
Query: 285 HGQ--CADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFEETEDA--CVPPAEAEAT 339
+ C D+DEC C KN C NT GS+ C+C GFE T D CV E T
Sbjct: 568 PTKQACIDIDECIQNGVLC--KNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTT 624
Score = 76.6 bits (187), Expect = 3e-14
Identities = 53/182 (29%), Positives = 72/182 (39%), Gaps = 38/182 (20%)
Query: 152 GHCSGDGSRQGDGSCRCHMGYQGPL----CTDCMDGYFSSLRNETHSICTACDESCKTCS 207
G C + +G C C +GY CTD + + + H+ C S K CS
Sbjct: 1339 GECE---NTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFK-CS 1394
Query: 208 GLTNRDCGECEVGWVLDEGACVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCT 267
C GW+ + C+D+DEC+ CS C N GSY C
Sbjct: 1395 ---------CREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRC----------- 1434
Query: 268 GEGPGNCKECISGYAREHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFEETE 327
C G+ + C+DVDEC AE + +N C N PG+Y C C GF
Sbjct: 1435 --------ACSEGFTGDGFTCSDVDEC--AENINLCENGQCLNVPGAYRCECEMGFTPAS 1484
Query: 328 DA 329
D+
Sbjct: 1485 DS 1486
Score = 73.2 bits (178), Expect = 3e-13
Identities = 47/144 (32%), Positives = 62/144 (43%), Gaps = 37/144 (25%)
Query: 201 ESCKTCSGL-TNRDCGE--------CEVGWVLDEG--ACVDVDECAAEPPPCSAAQFCKN 249
+ CK L TN C C+VG+ D +C+D+DEC+ P PC+ CKN
Sbjct: 2451 DECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCN--YICKN 2508
Query: 250 ANGSYTCEECDSSCVGCTGEGPGNCKECISGYA-REHGQ-CADVDECSLAEKTCVRKNEN 307
GSY C C GY +E G+ C D+DEC + C
Sbjct: 2509 TEGSYQCS-------------------CPRGYVLQEDGKTCKDLDECQTKQHNC---QFL 2546
Query: 308 CYNTPGSYVCVCPDGFEETEDACV 331
C NT G + C CP GF + AC+
Sbjct: 2547 CVNTLGGFTCKCPPGFTQHHTACI 2570
Score = 72.4 bits (176), Expect = 6e-13
Identities = 61/212 (28%), Positives = 78/212 (36%), Gaps = 48/212 (22%)
Query: 151 NGHCSGDGSRQGDGSCRCHMGYQGPL----CTDCMDGYFSSLRNETHSICTACDESCKTC 206
NG C + G C C+ GYQ CTD +E + CD C
Sbjct: 1213 NGKCV---NMIGTYQCSCNPGYQATPDRQGCTDI---------DECMIMNGGCDTQCTNS 1260
Query: 207 SGLTNRDCGECEVGWVL--DEGACVDVDECAAEPPPCSAAQFCKNANGSYTC-------- 256
G C E G+ L D +C D+DEC P C Q C N G Y C
Sbjct: 1261 EGSYECSCSE---GYALMPDGRSCADIDECENNPDICDGGQ-CTNIPGEYRCLCYDGFMA 1316
Query: 257 ----------EECDSSCVGCTGEGPGNCK-----ECISGYAREHGQ--CADVDECSLAEK 299
ECD + C N K C GY+ + G C DVDEC +
Sbjct: 1317 SMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAH 1376
Query: 300 TCVRKNENCYNTPGSYVCVCPDGFEETEDACV 331
C + +C N PGS+ C C +G+ C+
Sbjct: 1377 NC-DMHASCLNIPGSFKCSCREGWIGNGIKCI 1407
Score = 70.9 bits (172), Expect = 2e-12
Identities = 69/245 (28%), Positives = 93/245 (37%), Gaps = 53/245 (21%)
Query: 123 TLKVCCSPG-TYGPDCLACQGGSQRPCSG---NGHC-SGDGSRQGDGSCRCHMGYQGPLC 177
+ K C PG P+ C + G NGHC + +GS + D +G G +C
Sbjct: 638 SFKCICKPGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVC 697
Query: 178 TD------CMDGY--------FSSLRNETHSICTACD----ESCKTCSGLTNRDC-GECE 218
D C G F ++ C D E C+ C + + G C
Sbjct: 698 VDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCS 757
Query: 219 VG-WVLDEGACVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKEC 277
G + +G D++ECA +P C A C+N GSY C C
Sbjct: 758 SGVGITVDGR--DINECALDPDIC-ANGICENLRGSYRCN-------------------C 795
Query: 278 ISGYAREHG--QCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDG--FEETEDACVPP 333
SGY + C D+DEC + C N C NTPGSY C CP G F + C
Sbjct: 796 NSGYEPDASGRNCIDIDECLVNRLLC--DNGLCRNTPGSYSCTCPPGYVFRTETETCEDI 853
Query: 334 AEAEA 338
E E+
Sbjct: 854 NECES 858
Score = 70.5 bits (171), Expect = 2e-12
Identities = 50/166 (30%), Positives = 69/166 (41%), Gaps = 35/166 (21%)
Query: 217 CEVGWVLD--EGACVDVDECAAEPPPCSAAQFCKNANGSYTCE----------------- 257
C G+ LD E C D+DEC P C + C N GS+ CE
Sbjct: 1100 CNSGFALDMEERNCTDIDECRISPDLCGSG-ICVNTPGSFECECFEGYESGFMMMKNCMD 1158
Query: 258 --ECDSSCVGCTG------EGPGNCKECISGY--AREHGQCADVDECSLAEKTCVRKNEN 307
EC+ + + C G EG C +C G+ + C D++ECSL++ C +N
Sbjct: 1159 IDECERNPLLCRGGTCVNTEGSFQC-DCPLGHELSPSREDCVDINECSLSDNLC--RNGK 1215
Query: 308 CYNTPGSYVCVCPDGFEETED--ACVPPAEAEATEGESPTQLPSRE 351
C N G+Y C C G++ T D C E G TQ + E
Sbjct: 1216 CVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSE 1261
Score = 69.7 bits (169), Expect = 4e-12
Identities = 52/189 (27%), Positives = 78/189 (41%), Gaps = 35/189 (18%)
Query: 137 CLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDCMDGYFSSLRNETHSIC 196
C+ + PC GNG C + G +C C+ G++ DC+D +E S
Sbjct: 1932 CMDVDECERHPC-GNGTCK---NTVGSYNCLCYPGFELTHNNDCLD------IDECSSFF 1981
Query: 197 TACDESCKTCSGLTNRDCGECEVGWVL--DEGACVDVDECAAEPPPCSAAQFCKNANGSY 254
+ + + + + C C G+ L D C+D +EC A P CS C+N GS+
Sbjct: 1982 GQVCRNGRCFNEIGSFKC-LCNEGYELTPDGKNCIDTNECVALPGSCSPGT-CQNLEGSF 2039
Query: 255 TCEECDSSCVGCTGEGPGNCKECISGYAREHGQCADVDECSLAEKTCVRKNENCYNTPGS 314
C C GY + C D++EC C+ + C NTPG
Sbjct: 2040 RCI-------------------CPPGYEVKSENCIDINECDEDPNICLFGS--CTNTPGG 2078
Query: 315 YVCVCPDGF 323
+ C+CP GF
Sbjct: 2079 FQCLCPPGF 2087
Score = 67.4 bits (163), Expect = 2e-11
Identities = 57/199 (28%), Positives = 75/199 (37%), Gaps = 46/199 (23%)
Query: 148 CSGNGHCSGDGSRQGDGSCRCHMGYQ-GPLCTDCMDGYFSSLRNETHSICTACDESCKT- 205
C G + +GS Q C C +G++ P DC+D NE C+ D C+
Sbjct: 1169 CRGGTCVNTEGSFQ----CDCPLGHELSPSREDCVD------INE----CSLSDNLCRNG 1214
Query: 206 -CSGLTNRDCGECEVGWVL--DEGACVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSS 262
C + C G+ D C D+DEC C C N+ GSY C
Sbjct: 1215 KCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQ--CTNSEGSYECS----- 1267
Query: 263 CVGCTGEGPGNCKECISGYAR--EHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCP 320
C GYA + CAD+DEC C C N PG Y C+C
Sbjct: 1268 --------------CSEGYALMPDGRSCADIDECENNPDIC--DGGQCTNIPGEYRCLCY 1311
Query: 321 DGFEETED--ACVPPAEAE 337
DGF + D C+ E +
Sbjct: 1312 DGFMASMDMKTCIDVNECD 1330
Score = 66.6 bits (161), Expect = 3e-11
Identities = 59/202 (29%), Positives = 75/202 (37%), Gaps = 46/202 (22%)
Query: 152 GHCSGDGSRQGDGS--CRCHMGYQ----GPLCTDCMDGYFSSLRNETHSICTACDE-SCK 204
G CS DGS C C MGY G C D + SI C +C
Sbjct: 2180 GICSNGQCINTDGSFRCECPMGYNLDYTGVRCVD----------TDECSIGNPCGNGTCT 2229
Query: 205 TCSGLTNRDCGE-CEVGWVLDEGACVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSSC 263
G +C E E G +++ C D++ECA P C+ C N GSY C
Sbjct: 2230 NVIGSFECNCNEGFEPGPMMN---CEDINECAQNPLLCAFR--CMNTFGSYECT------ 2278
Query: 264 VGCTGEGPGNCKECISGYAREHGQ--CADVDECSLAEKTCVRKNENCYNTPGSYVCVCPD 321
C GYA Q C D+DEC+ C + C N G+++C+CP
Sbjct: 2279 -------------CPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPP 2325
Query: 322 GFEETED--ACVPPAEAEATEG 341
G D CV E G
Sbjct: 2326 GMARRPDGEGCVDENECRTKPG 2347
Score = 62.4 bits (150), Expect = 6e-10
Identities = 65/227 (28%), Positives = 81/227 (35%), Gaps = 48/227 (21%)
Query: 140 CQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDCMDGYFSSLRNETHSICTAC 199
C G C N C G C C G++ C+D RNE I C
Sbjct: 1854 CSNGDNL-CQRNADCINS---PGSYRCECAAGFKLSPNGACVD------RNECLEIPNVC 1903
Query: 200 DESCKTCSGLTNRDCGECEVGWVL--DEGACVDVDECAAEPPPCSAAQFCKNANGSYTC- 256
C L C G+ D+ C+DVDEC E PC CKN GSY C
Sbjct: 1904 SHGL--CVDLQGSYQCICHNGFKASQDQTMCMDVDEC--ERHPCGNGT-CKNTVGSYNCL 1958
Query: 257 ----------------EECDSSCVG-------CTGE-GPGNCKECISGY--AREHGQCAD 290
+EC SS G C E G C C GY + C D
Sbjct: 1959 CYPGFELTHNNDCLDIDEC-SSFFGQVCRNGRCFNEIGSFKCL-CNEGYELTPDGKNCID 2016
Query: 291 VDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFEETEDACVPPAEAE 337
+EC +C C N GS+ C+CP G+E + C+ E +
Sbjct: 2017 TNECVALPGSC--SPGTCQNLEGSFRCICPPGYEVKSENCIDINECD 2061
Score = 62.0 bits (149), Expect = 8e-10
Identities = 55/185 (29%), Positives = 75/185 (40%), Gaps = 39/185 (21%)
Query: 147 PCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDCMDGYFSSLRNETHSICTACDESCKTC 206
PC GNG C+ + G C C+ G++ +C D NE C C
Sbjct: 2222 PC-GNGTCT---NVIGSFECNCNEGFEPGPMMNCED------INECAQNPLLCAFRCMNT 2271
Query: 207 SGLTNRDCGECEVGWVL--DEGACVDVDECAAEPPPC-SAAQFCKNANGSYTCEECDSSC 263
G + +C C +G+ L D+ C D+DECA C S CKN G++ C
Sbjct: 2272 FG--SYEC-TCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCI------ 2322
Query: 264 VGCTGEGPGNCKECISGYARE-HGQ-CADVDECSLAEKTCVRKNENCYNTPGSYVCVCPD 321
C G AR G+ C D +EC C +N C N GSY C C +
Sbjct: 2323 -------------CPPGMARRPDGEGCVDENECRTKPGIC--ENGRCVNIIGSYRCECNE 2367
Query: 322 GFEET 326
GF+ +
Sbjct: 2368 GFQSS 2372
Score = 55.8 bits (133), Expect = 6e-08
Identities = 32/97 (32%), Positives = 46/97 (47%), Gaps = 24/97 (24%)
Query: 230 DVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGYA--REHGQ 287
D++EC A P C+ + C+N GS+ C C SG+A E
Sbjct: 1073 DINECKAFPGMCTYGK-CRNTIGSFKCR-------------------CNSGFALDMEERN 1112
Query: 288 CADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFE 324
C D+DEC ++ C + C NTPGS+ C C +G+E
Sbjct: 1113 CTDIDECRISPDLC--GSGICVNTPGSFECECFEGYE 1147
Score = 54.3 bits (129), Expect = 2e-07
Identities = 44/140 (31%), Positives = 59/140 (42%), Gaps = 32/140 (22%)
Query: 216 ECEVGWVLDEG--ACVDVDECAAEPPPCSAAQFCKNANGSYTCE-------ECDSSCVG- 265
EC G+ ++ C D+DEC+ C C N+ GSY CE + +CV
Sbjct: 1834 ECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNGACVDR 1893
Query: 266 --CTGEGPGNCKE-------------CISGY--AREHGQCADVDECSLAEKTCVRKNENC 308
C E P C C +G+ +++ C DVDEC C N C
Sbjct: 1894 NECL-EIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECE--RHPC--GNGTC 1948
Query: 309 YNTPGSYVCVCPDGFEETED 328
NT GSY C+C GFE T +
Sbjct: 1949 KNTVGSYNCLCYPGFELTHN 1968
Score = 52.8 bits (125), Expect = 5e-07
Identities = 65/261 (24%), Positives = 87/261 (33%), Gaps = 82/261 (31%)
Query: 128 CSPG---TYGPDCL---ACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQ-GPLCTDC 180
C PG T+ DCL C + C NG C + G C C+ GY+ P +C
Sbjct: 1959 CYPGFELTHNNDCLDIDECSSFFGQVCR-NGRCFNE---IGSFKCLCNEGYELTPDGKNC 2014
Query: 181 MDGYFSSLRNETHSICTACDESCK--TCSGLTNRDCGECEVGWVLDEGACVDVDECAAEP 238
+D NE C A SC TC L C G+ + C+D++EC +P
Sbjct: 2015 ID------TNE----CVALPGSCSPGTCQNLEGSFRCICPPGYEVKSENCIDINECDEDP 2064
Query: 239 PPCSAAQFCKNANGSYTC----------------------------------------EE 258
C C N G + C +
Sbjct: 2065 NICLFGS-CTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTK 2123
Query: 259 CDSSCVGCTGEGPGN-CKEC----------ISGYARE-----HGQCADVDECSLAEKTCV 302
C GEG G+ C+ C + Y H DV+EC + C
Sbjct: 2124 AKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGIC- 2182
Query: 303 RKNENCYNTPGSYVCVCPDGF 323
N C NT GS+ C CP G+
Sbjct: 2183 -SNGQCINTDGSFRCECPMGY 2202
Score = 52.4 bits (124), Expect = 6e-07
Identities = 64/269 (23%), Positives = 93/269 (34%), Gaps = 79/269 (29%)
Query: 129 SPGTYGPDCLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDCMDGYFSSL 188
+PG+Y C G CS C+ + + +G C + G +C G+ +
Sbjct: 1428 TPGSYRCACSEGFTGDGFTCSDVDECAENINLCENGQC---LNVPGAYRCECEMGFTPAS 1484
Query: 189 RNETHSICTACDESC-------KTCSGLTNRDCGECEVGWVLDE--GACVDVDECAAEPP 239
+ + C DE TC+ L C+ G+ LD G C D+DECA +P
Sbjct: 1485 DSRS---CQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECA-DPI 1540
Query: 240 PCSAAQFCKNANGSYTCE-----ECDSSCVGCT--------------GEGPGNCKECIS- 279
C C N G Y C + + + VGC G+G +C I
Sbjct: 1541 NCVNG-LCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGV 1599
Query: 280 GYAREHGQCA----------------------------------------DVDECSLAEK 299
G +R C+ D+DEC
Sbjct: 1600 GVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPG 1659
Query: 300 TCVRKNENCYNTPGSYVCVCPDGFEETED 328
C + NC NT GS+ C CP G+ +ED
Sbjct: 1660 LC--QGGNCINTFGSFQCECPQGYYLSED 1686
Score = 52.0 bits (123), Expect = 8e-07
Identities = 58/204 (28%), Positives = 75/204 (36%), Gaps = 22/204 (10%)
Query: 128 CSPGTYGPDCLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDCMDGYFSS 187
C+ G Y PD S R C C + +G CR G CT C GY
Sbjct: 795 CNSG-YEPDA------SGRNCIDIDECLVNRLLCDNGLCRNTPGSYS--CT-CPPGYVFR 844
Query: 188 LRNETHSICTACDESCKTCSGLTNRDCG----ECEVGWVLDEGACVDVDECAAEPPPCSA 243
ET C ES +G + G EC G L + +D
Sbjct: 845 TETETCEDINEC-ESNPCVNGACRNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQ 903
Query: 244 AQFCK-NANGSYTCEECDSSCVGCTGEGPGNCK---ECISGYAREHG-QCADVDECSLAE 298
C+ N NG+ EC ++ G C+ C G AR G C DV+EC +
Sbjct: 904 DSRCEVNINGATLKSECCATLGAAWGSPCERCELDTACPRGLARIKGVTCEDVNECEVFP 963
Query: 299 KTCVRKNENCYNTPGSYVCVCPDG 322
C N C N+ GS+ C CP+G
Sbjct: 964 GVC--PNGRCVNSKGSFHCECPEG 985
Score = 48.9 bits (115), Expect = 7e-06
Identities = 30/93 (32%), Positives = 37/93 (39%), Gaps = 24/93 (25%)
Query: 230 DVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGY--AREHGQ 287
D+DEC P C C N GS+ CE C GY + +
Sbjct: 1650 DIDECQELPGLCQGGN-CINTFGSFQCE-------------------CPQGYYLSEDTRI 1689
Query: 288 CADVDECSLAEKTCVRKNENCYNTPGSYVCVCP 320
C D+DEC C CYNT G+Y C+CP
Sbjct: 1690 CEDIDECFAHPGVC--GPGTCYNTLGNYTCICP 1720
Score = 47.0 bits (110), Expect = 3e-05
Identities = 50/190 (26%), Positives = 63/190 (33%), Gaps = 62/190 (32%)
Query: 216 ECEVGWVLDEGA--CVDVDECAAEPPPCSAAQFCKNANGSYTC----------------- 256
EC G+ L E C D+DEC A P C C N G+YTC
Sbjct: 1676 ECPQGYYLSEDTRICEDIDECFAHPGVCGPGT-CYNTLGNYTCICPPEYMQVNGGHNCMD 1734
Query: 257 ---EECDSSCVG--CTGEGPGN-------------------CKEC--------------I 278
C S G C E P N C+ C I
Sbjct: 1735 MRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNI 1794
Query: 279 SGYARE--HGQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFEETEDACVPPAEA 336
G+ + G+ D+DEC C N C N GS+ C CP GF + V
Sbjct: 1795 PGFTFDIHTGKAVDIDECKEIPGICA--NGVCINQIGSFRCECPTGFSYNDLLLVCEDID 1852
Query: 337 EATEGESPTQ 346
E + G++ Q
Sbjct: 1853 ECSNGDNLCQ 1862
>gi|61743978 stabilin 1 precursor [Homo sapiens]
Length = 2570
Score = 84.3 bits (207), Expect = 1e-16
Identities = 62/226 (27%), Positives = 93/226 (41%), Gaps = 33/226 (14%)
Query: 119 FCVKTL--KVCCSPGTYGPDCLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPL 176
+C +T+ + CC G +GPDC C GG PC G G+CS DG QG+G+C C Y+G
Sbjct: 710 YCNQTIMEQGCCK-GFFGPDCTQCPGGFSNPCYGKGNCS-DGI-QGNGACLCFPDYKGIA 766
Query: 177 CTDCMDGYFSSLRNETHSICTACDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDECAA 236
C C + + C E C GL + G G V +G C
Sbjct: 767 CHIC---------SNPNKHGEQCQEDCGCVHGLCDNRPGS---GGVCQQGTCA------- 807
Query: 237 EPPPCSAAQFCKNANG----SYTCEECDSSCVGCTGEGPGNCKECISGYAREHGQCADVD 292
P + +FC + G + + C + EG C+ C+ G+ + C +
Sbjct: 808 ---PGFSGRFCNESMGDCGPTGLAQHCHLHARCVSQEGVARCR-CLDGFEGDGFSCTPSN 863
Query: 293 ECSLAEKTCVRKNENCY-NTPGSYVCVCPDGFEETEDACVPPAEAE 337
CS ++ +N C + G++ C C G+ CV E E
Sbjct: 864 PCSHPDRGGCSENAECVPGSLGTHHCTCHKGWSGDGRVCVAIDECE 909
Score = 79.3 bits (194), Expect = 5e-15
Identities = 61/249 (24%), Positives = 94/249 (37%), Gaps = 38/249 (15%)
Query: 88 FECNQMLEAQEEHLEAWWLQLKSEYPDLFEWFCVKTLKVC-CSPGTYGPDCLACQGGSQR 146
F C Q + Q+ ++ + + + C K ++V C PG +G C C GG
Sbjct: 1279 FRCTQGFQLQDTPRKSCVYRSGFSFSRGCSYTCAKKIQVPDCCPGFFGTLCEPCPGGLGG 1338
Query: 147 PCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDCMDGYFSSLRNETHSICTACDESCKTC 206
CSG+G C G G C CH G+ G C C G + C
Sbjct: 1339 VCSGHGQC--QDRFLGSGECHCHEGFHGTACEVCELGRYG-----------------PNC 1379
Query: 207 SGLTNRDCGECEVGWVLDEGACVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSSC--- 263
+G+ + G C+ G + +G+CV C+ + T +C C
Sbjct: 1380 TGVCDCAHGLCQEG-LQGDGSCV-----------CNVGWQGLRCDQKITSPQCPRKCDPN 1427
Query: 264 VGCTGEGPG-NCKECISGYAREHGQCADVDECSLAEKTCVRKNENCYN-TPGSYVCVCPD 321
C + G + C +GY+ C++VD C+ C + NC PG C C D
Sbjct: 1428 ANCVQDSAGASTCACAAGYSGNGIFCSEVDPCAHGHGGC-SPHANCTKVAPGQRTCTCQD 1486
Query: 322 GFEETEDAC 330
G+ + C
Sbjct: 1487 GYMGDGELC 1495
Score = 77.4 bits (189), Expect = 2e-14
Identities = 71/258 (27%), Positives = 94/258 (36%), Gaps = 51/258 (19%)
Query: 120 CVKTL-KVCCSPGTYGPDCLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCT 178
CV T K C PG YG +C AC GG PCS G C DG G G C C G+ G C
Sbjct: 1950 CVTTTWKPSCCPGHYGSECQACPGGPSSPCSDRGVCM-DG-MSGSGQCLCRSGFAGTACE 2007
Query: 179 DCMDGYFSSLRNETHSICTACDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDECAAEP 238
C G F H C + GL C+ GW V ++
Sbjct: 2008 LCAPGAFG-----PHCQACRCTVHGRCDEGLGGSGSCFCDEGWT-GPRCEVQLELQPVCT 2061
Query: 239 PPCSAAQFCKNANGSYTCEECDSSCVG----CT-----GEGPGNCKE------------- 276
PPC+ C+ N EC G CT +G G C E
Sbjct: 2062 PPCAPEAVCRAGNSC----ECSLGYEGDGRVCTVADLCQDGHGGCSEHANCSQVGTMVTC 2117
Query: 277 -CISGYAREHGQCADVDECSLAEKTCVRKNENCYNTP-GSYVCVCPDGF--------EET 326
C+ Y + C + C+ + ++ NC +T + C C G+ EE+
Sbjct: 2118 TCLPDYEGDGWSCRARNPCTDGHRGGCSEHANCLSTGLNTRRCECHAGYVGDGLQCLEES 2177
Query: 327 E---DACV---PPAEAEA 338
E D C+ PP ++A
Sbjct: 2178 EPPVDRCLGQPPPCHSDA 2195
Score = 75.5 bits (184), Expect = 7e-14
Identities = 60/216 (27%), Positives = 85/216 (39%), Gaps = 26/216 (12%)
Query: 125 KVCCSPGTYGPDCLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDCMDGY 184
K CC PG +G C C GG++ PC+G+G C R +G+C C ++G C +C D
Sbjct: 98 KACC-PGYWGSRCHECPGGAETPCNGHGTCLDGMDR--NGTCVCQENFRGSACQECQDPN 154
Query: 185 -----FSSLRNETHSICT---ACDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDECAA 236
S+ + H +C D SC +G T C + E+ V E C +C+A
Sbjct: 155 RFGPDCQSVCSCVHGVCNHGPRGDGSCLCFAGYTGPHCDQ-ELP-VCQELRCPQNTQCSA 212
Query: 237 EPPPC-------SAAQFCKNANGSY--TCEECDSSCVGCTGEGPGNCKECISGYAREHGQ 287
E P C C+ N + C V G+ +C E Y +
Sbjct: 213 EAPSCRCLPGYTQQGSECRAPNPCWPSPCSLLAQCSVSPKGQAQCHCPE---NYHGDGMV 269
Query: 288 CADVDECSLAEKTCVRKNENC-YNTPGSYVCVCPDG 322
C D C+ C + C Y PG C C G
Sbjct: 270 CLPKDPCTDNLGGCPSNSTLCVYQKPGQAFCTCRPG 305
Score = 60.5 bits (145), Expect = 2e-09
Identities = 54/202 (26%), Positives = 74/202 (36%), Gaps = 33/202 (16%)
Query: 128 CSPGTYGPDCLACQG-----GSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDCMD 182
C+PG G C G G + C + C S++G CRC G++G D
Sbjct: 806 CAPGFSGRFCNESMGDCGPTGLAQHCHLHARCV---SQEGVARCRCLDGFEG-------D 855
Query: 183 GYFSSLRNE-THSICTACDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDECAAEPPPC 241
G+ + N +H C E+ + G C GW D CV +DEC +
Sbjct: 856 GFSCTPSNPCSHPDRGGCSENAECVPGSLGTHHCTCHKGWSGDGRVCVAIDECELDM--- 912
Query: 242 SAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGYAREHGQCADVDECSLAEKTC 301
G +T D+ C G G C C G+A + QC+ +D C C
Sbjct: 913 --------RGGCHT----DALC-SYVGPGQSRCT-CKLGFAGDGYQCSPIDPCRAGNGGC 958
Query: 302 VRKNENCYNTPGSYVCVCPDGF 323
G VC CP GF
Sbjct: 959 HGLATCRAVGGGQRVCTCPPGF 980
Score = 52.4 bits (124), Expect = 6e-07
Identities = 50/190 (26%), Positives = 66/190 (34%), Gaps = 71/190 (37%)
Query: 128 CSPGTYGPDCLACQ----GGSQRPCSGNGHCSGDGSRQGD-------------------- 163
C+PG +GP C AC+ G G+G C D G
Sbjct: 2009 CAPGAFGPHCQACRCTVHGRCDEGLGGSGSCFCDEGWTGPRCEVQLELQPVCTPPCAPEA 2068
Query: 164 -----GSCRCHMGYQGP--LCTD---CMDGYFSSLRNETHS------ICTACDE------ 201
SC C +GY+G +CT C DG+ + S CT +
Sbjct: 2069 VCRAGNSCECSLGYEGDGRVCTVADLCQDGHGGCSEHANCSQVGTMVTCTCLPDYEGDGW 2128
Query: 202 SCKT-----------CS--------GLTNRDCGECEVGWVLDEGACVD-----VDECAAE 237
SC+ CS GL R C EC G+V D C++ VD C +
Sbjct: 2129 SCRARNPCTDGHRGGCSEHANCLSTGLNTRRC-ECHAGYVGDGLQCLEESEPPVDRCLGQ 2187
Query: 238 PPPCSAAQFC 247
PPPC + C
Sbjct: 2188 PPPCHSDAMC 2197
Score = 32.7 bits (73), Expect = 0.50
Identities = 38/153 (24%), Positives = 53/153 (34%), Gaps = 28/153 (18%)
Query: 128 CSPGTYGPDCLACQGGSQR---------PCS-GNGHCSGDGS----RQGDGSCRCHMGYQ 173
C + G AC G PC+ G+G CS + G +C C GY
Sbjct: 1430 CVQDSAGASTCACAAGYSGNGIFCSEVDPCAHGHGGCSPHANCTKVAPGQRTCTCQDGYM 1489
Query: 174 GP--LCTDCMDGYFSSLRNETHSICTACDESCKTCSGLTNRDCGECEVGWVLDE-GACVD 230
G LC + H+ C +CS C G+ D C
Sbjct: 1490 GDGELCQEINSCLIHHGGCHIHAECIPTGPQQVSCS---------CREGYSGDGIRTCEL 1540
Query: 231 VDECAAEPPPCSAAQFCKN-ANGSYTCEECDSS 262
+D C+ CS CK+ +G TC CD++
Sbjct: 1541 LDPCSKNNGGCSPYATCKSTGDGQRTC-TCDTA 1572
>gi|126091152 cubilin [Homo sapiens]
Length = 3623
Score = 83.2 bits (204), Expect = 3e-16
Identities = 73/255 (28%), Positives = 98/255 (38%), Gaps = 62/255 (24%)
Query: 118 WFCVKTLKVCCSPGTYGPDCLA----CQ--GGSQRPCSGNGHCSGDGSRQGDGSCRCHMG 171
+FC+ C P GP C A C+ G+ C G C + G SC C
Sbjct: 154 FFCI------CPPQWKGPLCSADVNECEIYSGTPLSCQNGGTCV---NTMGSYSCHCPPE 204
Query: 172 YQGPLCT----DCMDGYFSSLRNETHSICTACDESCKTCSGLTNRDCGECEVGWVLDEG- 226
GP C DC G S+ H IC ++ + +G C C+ GW+
Sbjct: 205 TYGPQCASKYDDCEGG---SVARCVHGIC---EDLMREQAGEPKYSC-VCDAGWMFSPNS 257
Query: 227 -AC-VDVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGYARE 284
AC +D DEC+ +P PCS C N GS+ C C + G +GY
Sbjct: 258 PACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQG-------------NGYI-- 302
Query: 285 HGQCADVDECSLAEKTC-VRKNENCYNTPGSYVC-VCPDGFE-------------ETEDA 329
C D++EC + C V C NTPGS C CP G++ +
Sbjct: 303 ---CEDINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGG 359
Query: 330 CVPPAEAEATEGESP 344
C P A +T G P
Sbjct: 360 CHPDASCSSTLGSLP 374
>gi|51873055 fibulin 2 isoform b precursor [Homo sapiens]
Length = 1184
Score = 82.0 bits (201), Expect = 7e-16
Identities = 62/206 (30%), Positives = 85/206 (41%), Gaps = 41/206 (19%)
Query: 148 CSGNGHCSGDGSRQGDGS-CRCHMGY----QGPLCTD---CMDGYFSSLRNETHSICTAC 199
C NG C S G + C C GY G C D C+ + R E H + T
Sbjct: 683 CKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDINECVTDLHTCSRGE-HCVNTLG 741
Query: 200 DESCKTCSGLTNRDCGECEVGWVLDEGACVDVDECAAEPPPCSAAQFCKNANGSYTCEEC 259
C LT CE G+ L +G C DVDECA C C+N GS+ C+
Sbjct: 742 SFHCY--KALT------CEPGYALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQA- 792
Query: 260 DSSCVGCTGEGPGNCKECISGYARE-HGQCADVDECSLAEKTCVRKNENCYNTPGSYVC- 317
+ C+ G+ ++ G C D++EC+ + C R +C NT GSY C
Sbjct: 793 --------------RQRCMDGFLQDPEGNCVDINECTSLSEPC-RPGFSCINTVGSYTCQ 837
Query: 318 ----VCPDGFEETEDA--CVPPAEAE 337
+C G+ ++D CV E E
Sbjct: 838 RNPLICARGYHASDDGTKCVDVNECE 863
Score = 62.8 bits (151), Expect = 5e-10
Identities = 55/186 (29%), Positives = 74/186 (39%), Gaps = 42/186 (22%)
Query: 180 CMDGYFSSLRNETHSI--CTACDESCKTCSGLTN--------RDCGECEVGW-VLDEGA- 227
CMDG+ I CT+ E C+ N R+ C G+ D+G
Sbjct: 796 CMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTK 855
Query: 228 CVDVDECAAEPPPCSAAQFCKNANGSYTCE-----ECDSSCVGCTG-----EGPGN-CK- 275
CVDV+EC C Q C N GSY C+ + D+ GC PG C+
Sbjct: 856 CVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQH 915
Query: 276 -----------ECISGY--AREHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDG 322
C SG+ A + +C DV+EC R ++ C N GSY C C G
Sbjct: 916 TCENTLGSYRCSCASGFLLAADGKRCEDVNECE-----AQRCSQECANIYGSYQCYCRQG 970
Query: 323 FEETED 328
++ ED
Sbjct: 971 YQLAED 976
Score = 60.1 bits (144), Expect = 3e-09
Identities = 55/186 (29%), Positives = 71/186 (38%), Gaps = 48/186 (25%)
Query: 148 CSGNGHCSGDG----SRQGDGSCRCHMGYQ----GPLCTDCMDGYFSSLRNETHSICTAC 199
C H G+G + G C C G+Q G C D + + S R C
Sbjct: 862 CETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGR--------LC 913
Query: 200 DESCKTCSGLTNRDCGECEVGWVL--DEGACVDVDECAAEPPPCSAAQFCKNANGSYTCE 257
+C+ G C G++L D C DV+EC A+ CS Q C N GSY C
Sbjct: 914 QHTCENTLGSYRCSCAS---GFLLAADGKRCEDVNECEAQR--CS--QECANIYGSYQCY 966
Query: 258 ECDSSCVGCTGEGPGNCKECISGY--AREHGQCADVDECSLAEKTCVRKNENCYNTPGSY 315
C GY A + C D+DEC A+ + C N PGSY
Sbjct: 967 -------------------CRQGYQLAEDGHTCTDIDEC--AQGAGILCTFRCLNVPGSY 1005
Query: 316 VCVCPD 321
C CP+
Sbjct: 1006 QCACPE 1011
Score = 57.4 bits (137), Expect = 2e-08
Identities = 59/206 (28%), Positives = 74/206 (35%), Gaps = 36/206 (17%)
Query: 130 PGTYGPDCLACQGGSQRPCSGNG-----HCSGDGSRQGDGSCRCHMGYQGPLCTDCMDGY 184
PG+Y DC A G QR G G C R +C +G C
Sbjct: 879 PGSYRCDCKA---GFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLA 935
Query: 185 FSSLRNETHSICTA--CDESCKTCSGLTNRDCGECEVGWVLDEGA--CVDVDECAAEPPP 240
R E + C A C + C G + C C G+ L E C D+DECA
Sbjct: 936 ADGKRCEDVNECEAQRCSQECANIYG--SYQC-YCRQGYQLAEDGHTCTDIDECAQGAGI 992
Query: 241 CSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGYAREHGQCADVDECSLAEKT 300
+ C N GSY C C T G C DVDEC+L
Sbjct: 993 LCTFR-CLNVPGSYQCA-CPEQGYTMTANGRS---------------CKDVDECALGTHN 1035
Query: 301 CVRKNENCYNTPGSYVCV---CPDGF 323
C + E C+N GS+ C+ CP +
Sbjct: 1036 C-SEAETCHNIQGSFRCLRFECPPNY 1060
Score = 46.6 bits (109), Expect = 3e-05
Identities = 45/170 (26%), Positives = 53/170 (31%), Gaps = 38/170 (22%)
Query: 114 DLFEWFCVKTLKVCCSPG---------TYGPDCLACQGG-----SQRPCSGNGHCSGDGS 159
D F C+ + SPG T G +C G + C C
Sbjct: 893 DAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQRC 952
Query: 160 RQ------GDGSCRCHMGYQ----GPLCTD---CMDGYFSSLRNETHSICTACDESCKTC 206
Q G C C GYQ G CTD C G C C
Sbjct: 953 SQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQG-----------AGILCTFRCLNV 1001
Query: 207 SGLTNRDCGECEVGWVLDEGACVDVDECAAEPPPCSAAQFCKNANGSYTC 256
G C E + +C DVDECA CS A+ C N GS+ C
Sbjct: 1002 PGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRC 1051
Score = 32.3 bits (72), Expect = 0.66
Identities = 19/57 (33%), Positives = 24/57 (42%), Gaps = 2/57 (3%)
Query: 290 DVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFEETEDACVPPAEAEATEGESPTQ 346
D DEC L + C NT GSY C C GF +D E + E+P +
Sbjct: 604 DQDECLLLPGELCQ--HLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQE 658
Score = 30.4 bits (67), Expect = 2.5
Identities = 41/154 (26%), Positives = 60/154 (38%), Gaps = 28/154 (18%)
Query: 217 CEVG--WVLDEGACVDVDECAAEPPPCSAAQFCKNANGSYTCEE-CDSSCVG------CT 267
C G W +D C+++ E E C AQ ++ SY E+ C + +G C
Sbjct: 446 CAAGQQWAIDNDECLEIPESGTEDNVCRTAQ--RHCCVSYLQEKSCMAGVLGAKEGETCG 503
Query: 268 GEGPGNCKECISGYAREHGQCADVDECSLAEKTCVRKNENCYNTPG-SYVC-----VCPD 321
E +C IS Y QC D C L + + ++C + P Y C C +
Sbjct: 504 AEDNDSCG--ISLYK----QCCDC--CGLGLRVRA-EGQSCESNPNLGYPCNHVMLSCCE 554
Query: 322 GFEE--TEDACVPPAEAEATEGESPTQLPSREDL 353
G E + PP A A S ++ RE L
Sbjct: 555 GEEPLIVPEVRRPPEPAAAPRRVSEAEMAGREAL 588
>gi|20336246 proprotein convertase subtilisin/kexin type 5
preproprotein [Homo sapiens]
Length = 913
Score = 81.3 bits (199), Expect = 1e-15
Identities = 65/220 (29%), Positives = 92/220 (41%), Gaps = 45/220 (20%)
Query: 131 GTYGPDCLACQGG---SQRPCSGNGHCSGDGSRQGDGS--CR-----CHMGYQGPLCTDC 180
G++G C++C+ G ++ S HC DGS Q CR C + CT+C
Sbjct: 698 GSHGDQCMSCKYGYFLNEETNSCVTHCP-DGSYQDTKKNLCRKCSENCKTCTEFHNCTEC 756
Query: 181 MDGYFSSLRNETHSI------------CTACDESCKTCSGLTNRDCGECEVGWVLDEGAC 228
DG SL+ S+ C C C TC+G C C G+ +++G C
Sbjct: 757 RDGL--SLQGSRCSVSCEDGRYFNGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRC 814
Query: 229 VDVDECAAEPPPCSAAQFCKNA--NGSYTCEECDSSCVGCTGEGPGNCKECISGYAREHG 286
V CS + + ++ NG +C++CD SC+ C G G NC C SGY + G
Sbjct: 815 VQ---------SCSISYYFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLG 865
Query: 287 Q------CADVDECSLAEK---TCVRKNENCYNTPGSYVC 317
C D E S AE V+KN C +C
Sbjct: 866 MCQMGAICKDATEESWAEGGFCMLVKKNNLCQRKVLQQLC 905
Score = 58.2 bits (139), Expect = 1e-08
Identities = 53/221 (23%), Positives = 77/221 (34%), Gaps = 70/221 (31%)
Query: 170 MGYQGP---LCTDCMDGYFSSLRNETHSI---------------CTACDESCKTCSGLTN 211
+G GP C DC+ Y+ L+N T C C +C++C G
Sbjct: 643 VGCDGPGPDHCNDCLH-YYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHG 701
Query: 212 RDCGECEVGWVLDE--GACVD--------------VDECAAEPPPCSAAQFCKNA----- 250
C C+ G+ L+E +CV +C+ C+ C
Sbjct: 702 DQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLS 761
Query: 251 -----------NGSY----TCEECDSSCVGCTGEGPGNCKECISGYAREHGQCADVDECS 295
+G Y C+ C C C G G C C GY E G+C V CS
Sbjct: 762 LQGSRCSVSCEDGRYFNGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRC--VQSCS 819
Query: 296 LA----------EKTCVRKNENCY--NTPGSYVCV-CPDGF 323
++ K+C + + +C N PG C CP G+
Sbjct: 820 ISYYFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGY 860
Score = 37.4 bits (85), Expect = 0.020
Identities = 24/90 (26%), Positives = 35/90 (38%), Gaps = 21/90 (23%)
Query: 259 CDSSC--VGCTGEGPGNCKECISGYAREHGQC-------------ADVDECSLAEKTCVR 303
CD C VGC G GP +C +C+ Y + AD C + C
Sbjct: 636 CDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHYHADKKRC----RKCAP 691
Query: 304 KNENCYNTPGSYVCVCPDGF--EETEDACV 331
E+C+ + G C G+ E ++CV
Sbjct: 692 NCESCFGSHGDQCMSCKYGYFLNEETNSCV 721
>gi|34734064 fibulin 1 isoform B precursor [Homo sapiens]
Length = 601
Score = 80.9 bits (198), Expect = 2e-15
Identities = 72/244 (29%), Positives = 93/244 (38%), Gaps = 65/244 (26%)
Query: 148 CSGNGHCSGDGSRQGDGS-CRCHMGYQ----GPLCTD---CMDGYFS------------S 187
C G G C GD C C +GYQ G C D C+ G S S
Sbjct: 180 CRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGS 239
Query: 188 LRNETHSICTAC-----DESCKTC----SGLTN----------------RDCGECEVGWV 222
R + S C D SCK SG+ N R +C+ G++
Sbjct: 240 FRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFI 299
Query: 223 LDE-GACVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGY 281
D G C+D++EC + PC C N GSYTC++ N C GY
Sbjct: 300 QDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQK--------------NVPNCGRGY 345
Query: 282 --AREHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDG--FEETEDACVPPAEAE 337
E +C DVDEC+ + C K C N+PGS+ C C G F+ CV E +
Sbjct: 346 HLNEEGTRCVDVDECAPPAEPC-GKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQ 404
Query: 338 ATEG 341
G
Sbjct: 405 RYPG 408
Score = 56.6 bits (135), Expect = 3e-08
Identities = 51/190 (26%), Positives = 74/190 (38%), Gaps = 44/190 (23%)
Query: 167 RCHMGYQGPLCTDCMDGYFSSLRNETHSICTACD--ESCKTCSG--LTNRDCGECEVGWV 222
+C G+ +C+D NE SI C +C G ++ C G+
Sbjct: 293 QCKSGFIQDALGNCID------INECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYH 346
Query: 223 LDEGA--CVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSS---------------CVG 265
L+E CVDVDECA PC C N+ GS+ CE C + C
Sbjct: 347 LNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCE-CKTGYYFDGISRMCVDVNECQR 405
Query: 266 CTGEGPGN-CKECISGY----------AREHGQCADVDECSLAEKTCVRKNENCYNTPGS 314
G G+ C+ + Y + + C D++ECS C ++ C N GS
Sbjct: 406 YPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS--SSPC---SQECANVYGS 460
Query: 315 YVCVCPDGFE 324
Y C C G++
Sbjct: 461 YQCYCRRGYQ 470
Score = 56.6 bits (135), Expect = 3e-08
Identities = 59/227 (25%), Positives = 78/227 (34%), Gaps = 76/227 (33%)
Query: 147 PCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDCMDGYFSSLRNETHSICTACDESCKTC 206
PC C G C C GY YF + +C +E C
Sbjct: 366 PCGKGHRCVNS---PGSFRCECKTGY-----------YFDGISR----MCVDVNE----C 403
Query: 207 SGLTNRDCGE------------CEVGWVL--DEGACVDVDECAAEPPPCSAAQFCKNANG 252
R CG C VG+ L D +C D++EC++ P CS Q C N G
Sbjct: 404 QRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP--CS--QECANVYG 459
Query: 253 SY----------------TCEE------------CDSSCVGCTGEGPGNCKECISGY--A 282
SY TCE+ C C+ G +C SGY A
Sbjct: 460 SYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPS--SGYRLA 517
Query: 283 REHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCV---CPDGFEET 326
C D+DEC C NE C+N G + C+ CP+ + +
Sbjct: 518 PNGRNCQDIDECVTGIHNC-SINETCFNIQGGFRCLAFECPENYRRS 563
Score = 36.2 bits (82), Expect = 0.046
Identities = 31/122 (25%), Positives = 37/122 (30%), Gaps = 18/122 (14%)
Query: 146 RPCSGNGHCSGDGSRQ------GDGSCRCHMGYQ-----GPLCTDCMDGYFSSLRNETHS 194
R C CS Q G C C GYQ G C D + +L H
Sbjct: 437 RSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDE---CALPTGGH- 492
Query: 195 ICTACDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDECAAEPPPCSAAQFCKNANGSY 254
C C G C + C D+DEC CS + C N G +
Sbjct: 493 ---ICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGF 549
Query: 255 TC 256
C
Sbjct: 550 RC 551
>gi|34734068 fibulin 1 isoform A precursor [Homo sapiens]
Length = 566
Score = 80.9 bits (198), Expect = 2e-15
Identities = 72/244 (29%), Positives = 93/244 (38%), Gaps = 65/244 (26%)
Query: 148 CSGNGHCSGDGSRQGDGS-CRCHMGYQ----GPLCTD---CMDGYFS------------S 187
C G G C GD C C +GYQ G C D C+ G S S
Sbjct: 180 CRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGS 239
Query: 188 LRNETHSICTAC-----DESCKTC----SGLTN----------------RDCGECEVGWV 222
R + S C D SCK SG+ N R +C+ G++
Sbjct: 240 FRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFI 299
Query: 223 LDE-GACVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGY 281
D G C+D++EC + PC C N GSYTC++ N C GY
Sbjct: 300 QDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQK--------------NVPNCGRGY 345
Query: 282 --AREHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDG--FEETEDACVPPAEAE 337
E +C DVDEC+ + C K C N+PGS+ C C G F+ CV E +
Sbjct: 346 HLNEEGTRCVDVDECAPPAEPC-GKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQ 404
Query: 338 ATEG 341
G
Sbjct: 405 RYPG 408
Score = 56.6 bits (135), Expect = 3e-08
Identities = 51/190 (26%), Positives = 74/190 (38%), Gaps = 44/190 (23%)
Query: 167 RCHMGYQGPLCTDCMDGYFSSLRNETHSICTACD--ESCKTCSG--LTNRDCGECEVGWV 222
+C G+ +C+D NE SI C +C G ++ C G+
Sbjct: 293 QCKSGFIQDALGNCID------INECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYH 346
Query: 223 LDEGA--CVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSS---------------CVG 265
L+E CVDVDECA PC C N+ GS+ CE C + C
Sbjct: 347 LNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCE-CKTGYYFDGISRMCVDVNECQR 405
Query: 266 CTGEGPGN-CKECISGY----------AREHGQCADVDECSLAEKTCVRKNENCYNTPGS 314
G G+ C+ + Y + + C D++ECS C ++ C N GS
Sbjct: 406 YPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS--SSPC---SQECANVYGS 460
Query: 315 YVCVCPDGFE 324
Y C C G++
Sbjct: 461 YQCYCRRGYQ 470
Score = 56.6 bits (135), Expect = 3e-08
Identities = 59/227 (25%), Positives = 78/227 (34%), Gaps = 76/227 (33%)
Query: 147 PCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDCMDGYFSSLRNETHSICTACDESCKTC 206
PC C G C C GY YF + +C +E C
Sbjct: 366 PCGKGHRCVNS---PGSFRCECKTGY-----------YFDGISR----MCVDVNE----C 403
Query: 207 SGLTNRDCGE------------CEVGWVL--DEGACVDVDECAAEPPPCSAAQFCKNANG 252
R CG C VG+ L D +C D++EC++ P CS Q C N G
Sbjct: 404 QRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP--CS--QECANVYG 459
Query: 253 SY----------------TCEE------------CDSSCVGCTGEGPGNCKECISGY--A 282
SY TCE+ C C+ G +C SGY A
Sbjct: 460 SYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPS--SGYRLA 517
Query: 283 REHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCV---CPDGFEET 326
C D+DEC C NE C+N G + C+ CP+ + +
Sbjct: 518 PNGRNCQDIDECVTGIHNC-SINETCFNIQGGFRCLAFECPENYRRS 563
Score = 36.2 bits (82), Expect = 0.046
Identities = 31/122 (25%), Positives = 37/122 (30%), Gaps = 18/122 (14%)
Query: 146 RPCSGNGHCSGDGSRQ------GDGSCRCHMGYQ-----GPLCTDCMDGYFSSLRNETHS 194
R C CS Q G C C GYQ G C D + +L H
Sbjct: 437 RSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDE---CALPTGGH- 492
Query: 195 ICTACDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDECAAEPPPCSAAQFCKNANGSY 254
C C G C + C D+DEC CS + C N G +
Sbjct: 493 ---ICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGF 549
Query: 255 TC 256
C
Sbjct: 550 RC 551
>gi|34734066 fibulin 1 isoform D [Homo sapiens]
Length = 703
Score = 80.9 bits (198), Expect = 2e-15
Identities = 72/244 (29%), Positives = 93/244 (38%), Gaps = 65/244 (26%)
Query: 148 CSGNGHCSGDGSRQGDGS-CRCHMGYQ----GPLCTD---CMDGYFS------------S 187
C G G C GD C C +GYQ G C D C+ G S S
Sbjct: 180 CRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGS 239
Query: 188 LRNETHSICTAC-----DESCKTC----SGLTN----------------RDCGECEVGWV 222
R + S C D SCK SG+ N R +C+ G++
Sbjct: 240 FRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFI 299
Query: 223 LDE-GACVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGY 281
D G C+D++EC + PC C N GSYTC++ N C GY
Sbjct: 300 QDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQK--------------NVPNCGRGY 345
Query: 282 --AREHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDG--FEETEDACVPPAEAE 337
E +C DVDEC+ + C K C N+PGS+ C C G F+ CV E +
Sbjct: 346 HLNEEGTRCVDVDECAPPAEPC-GKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQ 404
Query: 338 ATEG 341
G
Sbjct: 405 RYPG 408
Score = 56.6 bits (135), Expect = 3e-08
Identities = 51/190 (26%), Positives = 74/190 (38%), Gaps = 44/190 (23%)
Query: 167 RCHMGYQGPLCTDCMDGYFSSLRNETHSICTACD--ESCKTCSG--LTNRDCGECEVGWV 222
+C G+ +C+D NE SI C +C G ++ C G+
Sbjct: 293 QCKSGFIQDALGNCID------INECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYH 346
Query: 223 LDEGA--CVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSS---------------CVG 265
L+E CVDVDECA PC C N+ GS+ CE C + C
Sbjct: 347 LNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCE-CKTGYYFDGISRMCVDVNECQR 405
Query: 266 CTGEGPGN-CKECISGY----------AREHGQCADVDECSLAEKTCVRKNENCYNTPGS 314
G G+ C+ + Y + + C D++ECS C ++ C N GS
Sbjct: 406 YPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS--SSPC---SQECANVYGS 460
Query: 315 YVCVCPDGFE 324
Y C C G++
Sbjct: 461 YQCYCRRGYQ 470
Score = 56.6 bits (135), Expect = 3e-08
Identities = 59/227 (25%), Positives = 78/227 (34%), Gaps = 76/227 (33%)
Query: 147 PCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDCMDGYFSSLRNETHSICTACDESCKTC 206
PC C G C C GY YF + +C +E C
Sbjct: 366 PCGKGHRCVNS---PGSFRCECKTGY-----------YFDGISR----MCVDVNE----C 403
Query: 207 SGLTNRDCGE------------CEVGWVL--DEGACVDVDECAAEPPPCSAAQFCKNANG 252
R CG C VG+ L D +C D++EC++ P CS Q C N G
Sbjct: 404 QRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP--CS--QECANVYG 459
Query: 253 SY----------------TCEE------------CDSSCVGCTGEGPGNCKECISGY--A 282
SY TCE+ C C+ G +C SGY A
Sbjct: 460 SYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPS--SGYRLA 517
Query: 283 REHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCV---CPDGFEET 326
C D+DEC C NE C+N G + C+ CP+ + +
Sbjct: 518 PNGRNCQDIDECVTGIHNC-SINETCFNIQGGFRCLAFECPENYRRS 563
Score = 36.2 bits (82), Expect = 0.046
Identities = 31/122 (25%), Positives = 37/122 (30%), Gaps = 18/122 (14%)
Query: 146 RPCSGNGHCSGDGSRQ------GDGSCRCHMGYQ-----GPLCTDCMDGYFSSLRNETHS 194
R C CS Q G C C GYQ G C D + +L H
Sbjct: 437 RSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDE---CALPTGGH- 492
Query: 195 ICTACDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDECAAEPPPCSAAQFCKNANGSY 254
C C G C + C D+DEC CS + C N G +
Sbjct: 493 ---ICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGF 549
Query: 255 TC 256
C
Sbjct: 550 RC 551
>gi|34734062 fibulin 1 isoform C precursor [Homo sapiens]
Length = 683
Score = 80.9 bits (198), Expect = 2e-15
Identities = 72/244 (29%), Positives = 93/244 (38%), Gaps = 65/244 (26%)
Query: 148 CSGNGHCSGDGSRQGDGS-CRCHMGYQ----GPLCTD---CMDGYFS------------S 187
C G G C GD C C +GYQ G C D C+ G S S
Sbjct: 180 CRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGS 239
Query: 188 LRNETHSICTAC-----DESCKTC----SGLTN----------------RDCGECEVGWV 222
R + S C D SCK SG+ N R +C+ G++
Sbjct: 240 FRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFI 299
Query: 223 LDE-GACVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGY 281
D G C+D++EC + PC C N GSYTC++ N C GY
Sbjct: 300 QDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQK--------------NVPNCGRGY 345
Query: 282 --AREHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDG--FEETEDACVPPAEAE 337
E +C DVDEC+ + C K C N+PGS+ C C G F+ CV E +
Sbjct: 346 HLNEEGTRCVDVDECAPPAEPC-GKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQ 404
Query: 338 ATEG 341
G
Sbjct: 405 RYPG 408
Score = 56.6 bits (135), Expect = 3e-08
Identities = 51/190 (26%), Positives = 74/190 (38%), Gaps = 44/190 (23%)
Query: 167 RCHMGYQGPLCTDCMDGYFSSLRNETHSICTACD--ESCKTCSG--LTNRDCGECEVGWV 222
+C G+ +C+D NE SI C +C G ++ C G+
Sbjct: 293 QCKSGFIQDALGNCID------INECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYH 346
Query: 223 LDEGA--CVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSS---------------CVG 265
L+E CVDVDECA PC C N+ GS+ CE C + C
Sbjct: 347 LNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCE-CKTGYYFDGISRMCVDVNECQR 405
Query: 266 CTGEGPGN-CKECISGY----------AREHGQCADVDECSLAEKTCVRKNENCYNTPGS 314
G G+ C+ + Y + + C D++ECS C ++ C N GS
Sbjct: 406 YPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS--SSPC---SQECANVYGS 460
Query: 315 YVCVCPDGFE 324
Y C C G++
Sbjct: 461 YQCYCRRGYQ 470
Score = 56.6 bits (135), Expect = 3e-08
Identities = 59/227 (25%), Positives = 78/227 (34%), Gaps = 76/227 (33%)
Query: 147 PCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDCMDGYFSSLRNETHSICTACDESCKTC 206
PC C G C C GY YF + +C +E C
Sbjct: 366 PCGKGHRCVNS---PGSFRCECKTGY-----------YFDGISR----MCVDVNE----C 403
Query: 207 SGLTNRDCGE------------CEVGWVL--DEGACVDVDECAAEPPPCSAAQFCKNANG 252
R CG C VG+ L D +C D++EC++ P CS Q C N G
Sbjct: 404 QRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP--CS--QECANVYG 459
Query: 253 SY----------------TCEE------------CDSSCVGCTGEGPGNCKECISGY--A 282
SY TCE+ C C+ G +C SGY A
Sbjct: 460 SYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPS--SGYRLA 517
Query: 283 REHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCV---CPDGFEET 326
C D+DEC C NE C+N G + C+ CP+ + +
Sbjct: 518 PNGRNCQDIDECVTGIHNC-SINETCFNIQGGFRCLAFECPENYRRS 563
Score = 36.2 bits (82), Expect = 0.046
Identities = 31/122 (25%), Positives = 37/122 (30%), Gaps = 18/122 (14%)
Query: 146 RPCSGNGHCSGDGSRQ------GDGSCRCHMGYQ-----GPLCTDCMDGYFSSLRNETHS 194
R C CS Q G C C GYQ G C D + +L H
Sbjct: 437 RSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDE---CALPTGGH- 492
Query: 195 ICTACDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDECAAEPPPCSAAQFCKNANGSY 254
C C G C + C D+DEC CS + C N G +
Sbjct: 493 ---ICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGF 549
Query: 255 TC 256
C
Sbjct: 550 RC 551
>gi|4557733 latent transforming growth factor beta binding protein 2
[Homo sapiens]
Length = 1821
Score = 80.5 bits (197), Expect = 2e-15
Identities = 68/215 (31%), Positives = 89/215 (41%), Gaps = 54/215 (25%)
Query: 129 SPGTYGPDCLACQGGSQ---------RPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTD 179
SPG+Y CLAC+ G + C G C+ +GS RC
Sbjct: 988 SPGSY--TCLACEEGYRGQSGSCVDVNECLTPGVCAHGKCTNLEGSFRC----------S 1035
Query: 180 CMDGYFSSLRNETHSICTACDE-----SCKTCSGLTNRD---CGECEVG-WVLDEG-ACV 229
C GY + + C DE SC T L C CE G WV ++G AC
Sbjct: 1036 CEQGYEVTSDEKG---CQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACE 1092
Query: 230 DVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGYAREHGQCA 289
D+DECA P + C N GS++C++CD G P + C
Sbjct: 1093 DLDECAF--PGVCPSGVCTNTAGSFSCKDCDG------GYRPSPLGD----------SCE 1134
Query: 290 DVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFE 324
DVDEC + +C+ C NT GSY C+CP GF+
Sbjct: 1135 DVDECEDPQSSCL--GGECKNTVGSYQCLCPQGFQ 1167
Score = 76.3 bits (186), Expect = 4e-14
Identities = 67/211 (31%), Positives = 89/211 (42%), Gaps = 47/211 (22%)
Query: 128 CSPG-TYGPDCLACQGGSQ---RPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDCMDG 183
CSPG P C ++ PC G G C +R G SC C+ GY L T
Sbjct: 872 CSPGYQLHPSQAYCTDDNECLRDPCKGKGRCI---NRVGSYSCFCYPGYT--LAT----- 921
Query: 184 YFSSLRNETHSICTACDESCKTCSG--LTNRDCG---ECEVGWVL-DEGACVDVDECAAE 237
S E I C++ CSG TN + EC+ G+++ +G C D++EC
Sbjct: 922 --SGATQECQDI-NECEQP-GVCSGGQCTNTEGSYHCECDQGYIMVRKGHCQDINECR-H 976
Query: 238 PPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGYAREHGQCADVDECSLA 297
P C + C N+ GSYTC C+ GY + G C DV+EC L
Sbjct: 977 PGTCPDGR-CVNSPGSYTCLACEE------------------GYRGQSGSCVDVNEC-LT 1016
Query: 298 EKTCVRKNENCYNTPGSYVCVCPDGFEETED 328
C + C N GS+ C C G+E T D
Sbjct: 1017 PGVCA--HGKCTNLEGSFRCSCEQGYEVTSD 1045
Score = 69.7 bits (169), Expect = 4e-12
Identities = 65/222 (29%), Positives = 85/222 (38%), Gaps = 42/222 (18%)
Query: 131 GTYGPDCLACQG---GSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDCMDGYFSS 187
G+Y CL QG + C C G+ G C + G C G+ S+
Sbjct: 1156 GSY--QCLCPQGFQLANGTVCEDVNECMGEEHCAPHGEC---LNSHGSFFCLCAPGFVSA 1210
Query: 188 LRNETHSICTACDESCKTCSGLTNRDCGE--------CEVGWVL--DEGACVDVDECAAE 237
E + C DE C T C CE G+ + G CVD+DEC
Sbjct: 1211 ---EGGTSCQDVDE-CATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDY 1266
Query: 238 PPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGYAREHGQCADVDECSLA 297
P C+N+ GSY C +GC PG + +G C D+DEC A
Sbjct: 1267 GDPVCGTWKCENSPGSYRC------VLGCQ---PG-------FHMAPNGDCIDIDEC--A 1308
Query: 298 EKTCVRKNENCYNTPGSYVCVCPDGFEETEDA--CVPPAEAE 337
T + C NT GS+ C+C GFE + CV E E
Sbjct: 1309 NDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECE 1350
Score = 69.3 bits (168), Expect = 5e-12
Identities = 64/228 (28%), Positives = 94/228 (41%), Gaps = 39/228 (17%)
Query: 128 CSPGTYGPDC-LACQG----GSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQ-GPLCTDCM 181
C+PG + +CQ + PC G GHC + +G +C C G+Q P +C+
Sbjct: 1203 CAPGFVSAEGGTSCQDVDECATTDPCVG-GHCV---NTEGSFNCLCETGFQPSPESGECV 1258
Query: 182 DGYFSSLRNETHSICTACDESCKTCSGLTNRDCGECEVGW-VLDEGACVDVDECAAEPPP 240
D + +C C+ G G C+ G+ + G C+D+DECA +
Sbjct: 1259 D--IDECEDYGDPVCGTW--KCENSPGSYRCVLG-CQPGFHMAPNGDCIDIDECANDTM- 1312
Query: 241 CSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGYAREHGQCADVDECSLAEKT 300
C + FC N +GS+ C CD + SG+ C DV+EC L
Sbjct: 1313 CGSHGFCDNTDGSFRCL-CDQGF-----------EISPSGW-----DCVDVNECELMLAV 1355
Query: 301 CVRKNENCYNTPGSYVCVCPDGFEE---TEDACVPPAEAEATEGESPT 345
C C N GS++C+C EE E C P + E+PT
Sbjct: 1356 CGAAL--CENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPT 1401
Score = 46.6 bits (109), Expect = 3e-05
Identities = 36/125 (28%), Positives = 47/125 (37%), Gaps = 30/125 (24%)
Query: 205 TCSGLTNRDCGECEVGWVL--DEGACVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSS 262
TC L + C G+ L + C D +EC +P C C N GSY+C
Sbjct: 860 TCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDP--CKGKGRCINRVGSYSCF----- 912
Query: 263 CVGCTGEGPGNCKECISGYAREHG----QCADVDECSLAEKTCVRKNENCYNTPGSYVCV 318
C GY +C D++EC E+ V C NT GSY C
Sbjct: 913 --------------CYPGYTLATSGATQECQDINEC---EQPGVCSGGQCTNTEGSYHCE 955
Query: 319 CPDGF 323
C G+
Sbjct: 956 CDQGY 960
Score = 43.5 bits (101), Expect = 3e-04
Identities = 59/241 (24%), Positives = 77/241 (31%), Gaps = 58/241 (24%)
Query: 137 CLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCT--DCMDGY-----FSSL- 188
CL C + + GHC G+ G G P T DC G SS+
Sbjct: 1370 CL-CASDLEEYDAQEGHCRPRGAG-GQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVL 1427
Query: 189 -RNETHSICTACD-----ESCKTCSGLTNRDCGEC----------EVGWVLDEGACVDVD 232
RN T + C ++C C + + E E W + D D
Sbjct: 1428 GRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDAD 1487
Query: 233 ECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGYAREHGQCADVD 292
EC P C N Y C C+ PG Y H +C D D
Sbjct: 1488 ECVIFGPGLCPNGRCLNTVPGYVCL-CN----------PG------FHYDASHKKCEDHD 1530
Query: 293 ECSLAEKTCVRKNENCYNTPGSYVCVCPDGFEETEDACVPPAEAEATEGESPTQLPSRED 352
EC + C +N C NT GS+ C C PP + ++ S ED
Sbjct: 1531 ECQ--DLAC--ENGECVNTEGSFHCFCS-----------PPLTLDLSQQRCMNSTSSTED 1575
Query: 353 L 353
L
Sbjct: 1576 L 1576
Score = 38.9 bits (89), Expect = 0.007
Identities = 24/69 (34%), Positives = 32/69 (46%), Gaps = 6/69 (8%)
Query: 276 ECISGYAREH-GQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDG--FEETEDACVP 332
EC GY R + C D++EC L C K+ C NT GSY+C C G + + CV
Sbjct: 607 ECPQGYKRLNLTHCQDINEC-LTLGLC--KDAECVNTRGSYLCTCRPGLMLDPSRSRCVS 663
Query: 333 PAEAEATEG 341
+G
Sbjct: 664 DKAISMLQG 672
Score = 36.2 bits (82), Expect = 0.046
Identities = 29/94 (30%), Positives = 38/94 (40%), Gaps = 9/94 (9%)
Query: 185 FSSLRNETHSICTACDESCKTCSGLTNRDCGECEVGWVLDEG--ACVDVDEC--AAEPPP 240
F L+ E I C+ C + +C G+ LD ACVDV+EC P
Sbjct: 1729 FEGLQAEECGILNGCENG--RCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAV 1786
Query: 241 CSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNC 274
+C+N GSY C C V GP +C
Sbjct: 1787 LCVHGYCENTEGSYRC-HCSPGYV--AEAGPPHC 1817
Score = 34.7 bits (78), Expect = 0.13
Identities = 20/61 (32%), Positives = 27/61 (44%), Gaps = 3/61 (4%)
Query: 266 CTGEGPGNCKECISGYARE--HGQCADVDECS-LAEKTCVRKNENCYNTPGSYVCVCPDG 322
C G +C G+ + H C DV+EC L + + C NT GSY C C G
Sbjct: 1748 CVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRCHCSPG 1807
Query: 323 F 323
+
Sbjct: 1808 Y 1808
>gi|115298674 nidogen 1 precursor [Homo sapiens]
Length = 1247
Score = 80.5 bits (197), Expect = 2e-15
Identities = 51/190 (26%), Positives = 78/190 (41%), Gaps = 36/190 (18%)
Query: 182 DGYFSSLRNETHSICTACDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDECAAEPPPC 241
+G +L+N + CD + G + EC +G+ D C D+DEC+ +P C
Sbjct: 662 EGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVC 721
Query: 242 SAAQFCKNANGSYTCE-------ECDSSCVGCTGEGPGNCKE------------------ 276
+ C N G++ CE + +CV + P N E
Sbjct: 722 GSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTG 781
Query: 277 -------CISGYAREHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFEETEDA 329
C+ G++ + C DVDEC + + + CYNTPGS+ C C G++
Sbjct: 782 GSSYTCSCLPGFSGDGQACQDVDEC---QPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFR 838
Query: 330 CVPPAEAEAT 339
CV P E E T
Sbjct: 839 CV-PGEVEKT 847
>gi|40807489 egf-like module containing, mucin-like, hormone
receptor-like sequence 1 [Homo sapiens]
Length = 886
Score = 79.3 bits (194), Expect = 5e-15
Identities = 62/200 (31%), Positives = 81/200 (40%), Gaps = 29/200 (14%)
Query: 130 PGTYGPDCLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDCMDGYFSSLR 189
PG D C Q PC N C R C C G+ P D + G +
Sbjct: 74 PGVRCKDIDECSQSPQ-PCGPNSSCKNLSGRY---KCSCLDGFSSPTGNDWVPGKPGNFS 129
Query: 190 NETHSIC---TACDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDECAAEPPPCSAAQF 246
+ C + C E + + + C C+VG++ C DVDECA +P C
Sbjct: 130 CTDINECLTSSVCPEHSDCVNSMGSYSCS-CQVGFISRNSTCEDVDECA-DPRACPEHAT 187
Query: 247 CKNANGSYTCEECDSSCVGCTGEGPGNCKECISGYAREHG---QCADVDECSLAEKTCVR 303
C N G+Y+C C+ PG E SG+ G C D+DEC+ + C
Sbjct: 188 CNNTVGNYSCF-CN----------PGF--ESSSGHLSFQGLKASCEDIDECT---EMCPI 231
Query: 304 KNENCYNTPGSYVCVCPDGF 323
N C NTPGSY C C GF
Sbjct: 232 -NSTCTNTPGSYFCTCHPGF 250
Score = 65.1 bits (157), Expect = 9e-11
Identities = 46/164 (28%), Positives = 61/164 (37%), Gaps = 45/164 (27%)
Query: 205 TCSGLTNRDCGECEVGWVLDEGA---------CVDVDECAAEPPPCSAAQFCKNANGSYT 255
TC+ + C+ G++ G C D+DEC+ P PC CKN +G Y
Sbjct: 46 TCTNTVDSYYCACKQGFLSSNGQNHFKDPGVRCKDIDECSQSPQPCGPNSSCKNLSGRYK 105
Query: 256 CEECDSSCVGCTGEG-----PGN--------------CKE--------------CISGYA 282
C C TG PGN C E C G+
Sbjct: 106 C-SCLDGFSSPTGNDWVPGKPGNFSCTDINECLTSSVCPEHSDCVNSMGSYSCSCQVGFI 164
Query: 283 REHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFEET 326
+ C DVDEC A+ ++ C NT G+Y C C GFE +
Sbjct: 165 SRNSTCEDVDEC--ADPRACPEHATCNNTVGNYSCFCNPGFESS 206
Score = 45.4 bits (106), Expect = 8e-05
Identities = 34/125 (27%), Positives = 48/125 (38%), Gaps = 24/125 (19%)
Query: 146 RPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDCMDGY--FSSLRNETHSICTACDESC 203
R C + C+ + G+ SC C+ G++ G+ F L+ I C E C
Sbjct: 180 RACPEHATCN---NTVGNYSCFCNPGFESS------SGHLSFQGLKASCEDI-DECTEMC 229
Query: 204 ---KTCSGLTNRDCGECEVGWVLDEGA---------CVDVDECAAEPPPCSAAQFCKNAN 251
TC+ C G+ G C D+DEC +P C C NA
Sbjct: 230 PINSTCTNTPGSYFCTCHPGFAPSNGQLNFTDQGVECRDIDECRQDPSTCGPNSICTNAL 289
Query: 252 GSYTC 256
GSY+C
Sbjct: 290 GSYSC 294
>gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens]
Length = 988
Score = 79.0 bits (193), Expect = 6e-15
Identities = 59/197 (29%), Positives = 76/197 (38%), Gaps = 50/197 (25%)
Query: 162 GDGSCR--CHMGYQGPLCTDCMDGYFSSLRNETHSICTACDESCKTCSGLTNRDCGE--- 216
G+G C+ C GP C C Y HS C E+C +G +R C +
Sbjct: 209 GNGGCQHSCEDTDTGPTC-GCHQKY------ALHSDGRTCIETCAVNNGGCDRTCKDTAT 261
Query: 217 -----CEVGWVL--DEGACVDVDECAAEPPPCSAAQFCKNANGSYTC------------- 256
C VG+ L D C D++EC C FC+N GS+ C
Sbjct: 262 GVRCSCPVGFTLQPDGKTCKDINECLVNNGGCD--HFCRNTVGSFECGCRKGYKLLTDER 319
Query: 257 -----------EECDSSCVGCTGEGPGNCKECISGYAREHGQCADVDECSLAEKTCVRKN 305
CD C+ G C Y H C DVDECS++ +C +
Sbjct: 320 TCQDIDECSFERTCDHICINSPGSFQCLCHRGYILYGTTH--CGDVDECSMSNGSC---D 374
Query: 306 ENCYNTPGSYVCVCPDG 322
+ C NT GSY CVCP G
Sbjct: 375 QGCVNTKGSYECVCPPG 391
Score = 57.0 bits (136), Expect = 2e-08
Identities = 38/117 (32%), Positives = 45/117 (38%), Gaps = 26/117 (22%)
Query: 229 VDVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGYAREHGQC 288
VDVDEC+ C C+N SY C C GY E QC
Sbjct: 32 VDVDECSEGTDDCHIDAICQNTPKSYKC-------------------LCKPGYKGEGKQC 72
Query: 289 ADVDEC--SLAEKTCVRKNENCYNTPGSYVCVCPDGFEETEDA--CVPPAEAEATEG 341
D+DEC CV + C N PG+Y C C DGF D C+ E + G
Sbjct: 73 EDIDECENDYYNGGCVHE---CINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNG 126
Score = 48.1 bits (113), Expect = 1e-05
Identities = 32/119 (26%), Positives = 43/119 (36%), Gaps = 26/119 (21%)
Query: 217 CEVGWVLDEGACVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKE 276
C+ G+ + C D+DEC + C N G+Y C
Sbjct: 61 CKPGYKGEGKQCEDIDECENDYYNGGCVHECINIPGNYRC-------------------T 101
Query: 277 CISGYAREHG--QCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGF--EETEDACV 331
C G+ H C DVDEC C + C N GSY C C GF + + C+
Sbjct: 102 CFDGFMLAHDGHNCLDVDECQDNNGGC---QQICVNAMGSYECQCHSGFFLSDNQHTCI 157
Score = 41.2 bits (95), Expect = 0.001
Identities = 49/218 (22%), Positives = 76/218 (34%), Gaps = 45/218 (20%)
Query: 136 DCLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGY--------------QGPLCTDCM 181
+C GG Q+ C + G C+CH G+ +G C +
Sbjct: 120 ECQDNNGGCQQICV---------NAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMN-K 169
Query: 182 DGYFSSLRNETHSICTACDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDECAAEPPPC 241
D + + ET ACD C+ L +C + G C E P C
Sbjct: 170 DHGCAHICRETPKGGVACD--CRPGFDLAQNQ-KDCTLTCNYGNGGCQHSCEDTDTGPTC 226
Query: 242 SAAQ-FCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGYA----------REHGQCAD 290
Q + +++G E C + GC CK+ +G + C D
Sbjct: 227 GCHQKYALHSDGRTCIETCAVNNGGCDR----TCKDTATGVRCSCPVGFTLQPDGKTCKD 282
Query: 291 VDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFEETED 328
++EC + C + C NT GS+ C C G++ D
Sbjct: 283 INECLVNNGGC---DHFCRNTVGSFECGCRKGYKLLTD 317
>gi|190343004 EGF-containing fibulin-like extracellular matrix
protein 2 [Homo sapiens]
Length = 443
Score = 78.6 bits (192), Expect = 8e-15
Identities = 46/127 (36%), Positives = 59/127 (46%), Gaps = 12/127 (9%)
Query: 216 ECEVG--WVLDEGACVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVG-CTGEGPG 272
EC G W D C DV+EC P C C N G Y C ++ + GEGP
Sbjct: 38 ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPP 97
Query: 273 -------NCKECISGYARE-HGQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFE 324
+ C GY + C DVDEC+ A C R +++C+N PGSY C CPDG+
Sbjct: 98 PPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDC-RPSQDCHNLPGSYQCTCPDGYR 156
Query: 325 ETEDACV 331
+ CV
Sbjct: 157 KIGPECV 163
Score = 61.2 bits (147), Expect = 1e-09
Identities = 58/209 (27%), Positives = 81/209 (38%), Gaps = 55/209 (26%)
Query: 128 CSPGTYGPD----CLACQGGSQ--RPCSGNGHCSGDGSRQGDGSCRCHMGYQ--GPLCTD 179
C PG Y PD C+ +Q C + C + G C C GY+ GP C D
Sbjct: 109 CPPG-YEPDDQDSCVDVDECAQALHDCRPSQDCH---NLPGSYQCTCPDGYRKIGPECVD 164
Query: 180 CMDGYFSSLRNETHSICTACDESCKTCSGLTNRDCGECEVGWVL--DEGACVDVDECAAE 237
+ + C C G C +CE G+ L + +CVDV+EC
Sbjct: 165 IDECRYRY-----------CQHRCVNLPGSFR--C-QCEPGFQLGPNNRSCVDVNECDMG 210
Query: 238 PPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGYA--REHGQCADVDECS 295
P Q C N+ G++ C C GY R+ C+D+DECS
Sbjct: 211 AP---CEQRCFNSYGTFLCR-------------------CHQGYELHRDGFSCSDIDECS 248
Query: 296 LAEKTCVRKNENCYNTPGSYVCVCPDGFE 324
+ C + C N PG + C CP G++
Sbjct: 249 YSSYLCQYR---CVNEPGRFSCHCPQGYQ 274
Score = 58.5 bits (140), Expect = 9e-09
Identities = 35/126 (27%), Positives = 49/126 (38%), Gaps = 26/126 (20%)
Query: 224 DEGACVDVDECAAEPPPCSAAQFCKNANGSYTC---------------------EECDSS 262
D+ +CVDVDECA C +Q C N GSY C C
Sbjct: 117 DQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHR 176
Query: 263 CVGCTGEGPGNCKECISGYAREHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDG 322
CV G C+ + C DV+EC + + C+N+ G+++C C G
Sbjct: 177 CVNLPGSFRCQCEPGFQ-LGPNNRSCVDVNECDMGAPC----EQRCFNSYGTFLCRCHQG 231
Query: 323 FEETED 328
+E D
Sbjct: 232 YELHRD 237
Score = 48.5 bits (114), Expect = 9e-06
Identities = 41/136 (30%), Positives = 55/136 (40%), Gaps = 21/136 (15%)
Query: 128 CSPG-TYGPDCLACQGGSQRPCSGNGHCSGDG-SRQGDGSCRCHMGYQ----GPLCTDCM 181
C PG GP+ +C ++ C C + G CRCH GY+ G C+D
Sbjct: 188 CEPGFQLGPNNRSCVDVNE--CDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDID 245
Query: 182 DGYFSSLRNETHSICTACDESCKTCSGLTNRDCGECEVGW-VLDEGACVDVDECAAEPPP 240
+ +SS C C G R C G+ +L C D+DEC +
Sbjct: 246 ECSYSSY---------LCQYRCVNEPG---RFSCHCPQGYQLLATRLCQDIDECESGAHQ 293
Query: 241 CSAAQFCKNANGSYTC 256
CS AQ C N +G Y C
Sbjct: 294 CSEAQTCVNFHGGYRC 309
>gi|144953895 nidogen 2 precursor [Homo sapiens]
Length = 1375
Score = 78.6 bits (192), Expect = 8e-15
Identities = 58/190 (30%), Positives = 76/190 (40%), Gaps = 17/190 (8%)
Query: 157 DGSRQGDGSCRCHMGYQGPLCTDCMDGYFSSLRN-ETHSICTACDESC---KTCSGLTNR 212
DGS D + RCH G +C GY RN + C C C L
Sbjct: 765 DGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCGPNSVCINLPGS 824
Query: 213 DCGECEVGWVLDEGACVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPG 272
EC G+ + D C PP + + +GS+TC + G
Sbjct: 825 YRCECRSGYEFAD----DRHTCILITPPANPCE-----DGSHTCAPAGQARCVHHGGSTF 875
Query: 273 NCKECISGYAREHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFEETEDACVP 332
+C C+ GYA + QC DVDECS E C CYNTPGS+ C C G+ C+P
Sbjct: 876 SC-ACLPGYAGDGHQCTDVDECS--ENRC-HPAATCYNTPGSFSCRCQPGYYGDGFQCIP 931
Query: 333 PAEAEATEGE 342
+ + T E
Sbjct: 932 DSTSSLTPCE 941
Score = 54.7 bits (130), Expect = 1e-07
Identities = 62/251 (24%), Positives = 86/251 (34%), Gaps = 41/251 (16%)
Query: 128 CSPGT---YGPDCLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDCMDGY 184
C PGT Y +C + G R C C+ R G S ++ G +C GY
Sbjct: 776 CHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCGPNSVCINL--PGSYRCECRSGY 833
Query: 185 FSSLRNETHSICTA----CDESCKTCSGLTNRDCGE---------CEVGWVLDEGACVDV 231
+ T + T C++ TC+ C C G+ D C DV
Sbjct: 834 EFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGYAGDGHQCTDV 893
Query: 232 DECAAEPPPCSAAQFCKNANGSYTCEECDSSCVG----CTGEGPGNCKECISGYAREHGQ 287
DEC+ C A C N GS++C C G C + + C Q
Sbjct: 894 DECSENR--CHPAATCYNTPGSFSCR-CQPGYYGDGFQCIPDSTSSLTPCEQQQRHAQAQ 950
Query: 288 CA------DVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFE----ETEDACVPPAEAE 337
A + +C + C+ + G CV PDG E +T PP
Sbjct: 951 YAYPGARFHIPQCDEQGNFLPLQ---CHGSTGFCWCVDPDGHEVPGTQTPPGSTPPHCGP 1007
Query: 338 ATEGESPTQLP 348
+ E PTQ P
Sbjct: 1008 SPE---PTQRP 1015
>gi|75709198 nephronectin [Homo sapiens]
Length = 565
Score = 78.6 bits (192), Expect = 8e-15
Identities = 62/226 (27%), Positives = 74/226 (32%), Gaps = 61/226 (26%)
Query: 140 CQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTD-------------------- 179
CQ Q C +G C G C+CH GY G C
Sbjct: 56 CQPVCQPRCK-HGECIGPNK------CKCHPGYAGKTCNQDLNECGLKPRPCKHRCMNTY 108
Query: 180 ------CMDGYFSSLRNETHSICTA----CDESCKTCSGLTNRDCGECEVGWVLDEGACV 229
C++GY S T C C G C + D CV
Sbjct: 109 GSYKCYCLNGYMLMPDGSCSSALTCSMANCQYGCDVVKGQIRCQCPSPGLQLAPDGRTCV 168
Query: 230 DVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISG----YAREH 285
DVDECA C + C N GSY C +C G Y
Sbjct: 169 DVDECATGRASCPRFRQCVNTFGSYIC-------------------KCHKGFDLMYIGGK 209
Query: 286 GQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFEETEDACV 331
QC D+DECSL + C CYN GSY C C +G++ CV
Sbjct: 210 YQCHDIDECSLGQYQC-SSFARCYNIRGSYKCKCKEGYQGDGLTCV 254
>gi|19743803 fibulin 5 precursor [Homo sapiens]
Length = 448
Score = 77.4 bits (189), Expect = 2e-14
Identities = 43/113 (38%), Positives = 49/113 (43%), Gaps = 25/113 (22%)
Query: 217 CEVGWVLDEG-ACVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCK 275
C G+ +DE CVDVDECA + C+ Q C N G YTC
Sbjct: 113 CRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTC------------------- 153
Query: 276 ECISGYAREHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFEETED 328
C GY GQC D+DEC C + C N PGSY C C GF ED
Sbjct: 154 SCTDGYWLLEGQCLDIDECRYG--YC---QQLCANVPGSYSCTCNPGFTLNED 201
Score = 70.9 bits (172), Expect = 2e-12
Identities = 56/184 (30%), Positives = 71/184 (38%), Gaps = 37/184 (20%)
Query: 168 CHMGYQGPLCTDCMDGYFSSLRNETHSICTACDESCKTCSGLTNRDCGECEVGWVLDEGA 227
C GYQ C+D ++H C T G T C C G+ L EG
Sbjct: 113 CRFGYQMDESNQCVD--VDECATDSHQ-CNPTQICINTEGGYT---CS-CTDGYWLLEGQ 165
Query: 228 CVDVDECAAEPPPCSAAQFCKNANGSYTC------------------EEC--DSSCVG-C 266
C+D+DEC Q C N GSY+C EC ++ CV C
Sbjct: 166 CLDIDECRYG----YCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTC 221
Query: 267 TGEGPGNCKECISGYAREHG--QCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFE 324
C GY E C+D+DECS +E C C N PG+Y C CP G+
Sbjct: 222 VNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLC---QHECVNQPGTYFCSCPPGYI 278
Query: 325 ETED 328
+D
Sbjct: 279 LLDD 282
Score = 64.7 bits (156), Expect = 1e-10
Identities = 43/143 (30%), Positives = 53/143 (37%), Gaps = 28/143 (19%)
Query: 216 ECEVGWVLDE--GACVDVDECAAEPPPCSAAQFCKNANGSYTC----------EECDSSC 263
+C G+ LD G C+D+DEC P C C N NG Y C +
Sbjct: 26 QCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRGPYSNPYS 85
Query: 264 VGCTGEGPGNCKE--------------CISGYAR-EHGQCADVDECSLAEKTCVRKNENC 308
+G P C GY E QC DVDEC+ C + C
Sbjct: 86 TPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDSHQC-NPTQIC 144
Query: 309 YNTPGSYVCVCPDGFEETEDACV 331
NT G Y C C DG+ E C+
Sbjct: 145 INTEGGYTCSCTDGYWLLEGQCL 167
Score = 61.6 bits (148), Expect = 1e-09
Identities = 67/239 (28%), Positives = 94/239 (39%), Gaps = 53/239 (22%)
Query: 138 LACQGGSQ----RPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDCMDGYFSSLRNETH 193
L C+ G Q C C+ D S Q + + C + +G C DGY+
Sbjct: 111 LICRFGYQMDESNQCVDVDECATD-SHQCNPTQIC-INTEGGYTCSCTDGYWL-----LE 163
Query: 194 SICTACDES----CKT-CSGLTNRDCGECEVGWVLDEG--ACVDVDECAAEPPPCSAAQF 246
C DE C+ C+ + C G+ L+E +C DV+ECA E P Q
Sbjct: 164 GQCLDIDECRYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENP---CVQT 220
Query: 247 CKNANGSYTC------------------EECDSSCVGCTGE---GPGN--CKECISGYAR 283
C N GS+ C +EC S C E PG C C GY
Sbjct: 221 CVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCS-CPPGYIL 279
Query: 284 --EHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFEE-----TEDACVPPAE 335
++ C D++EC TC + CYN G + C+ P EE +++ C+ PAE
Sbjct: 280 LDDNRSCQDINECEHRNHTC-NLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAE 337
Score = 47.0 bits (110), Expect = 3e-05
Identities = 45/168 (26%), Positives = 66/168 (39%), Gaps = 35/168 (20%)
Query: 128 CSPG-TYGPDCLACQGGSQRPCSGNGHCSGDG-SRQGDGSCRCHMGYQ----GPLCTDCM 181
C+PG T D +CQ ++ C+ C + G CRC GY+ G C+D
Sbjct: 192 CNPGFTLNEDGRSCQDVNE--CATENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMD 249
Query: 182 DGYFSSLRNETHSICTACDESCKTCSGLTNRDCGECEVGWVL--DEGACVDVDECAAEPP 239
+ FS C C G C C G++L D +C D++EC
Sbjct: 250 ECSFSEF---------LCQHECVNQPG--TYFCS-CPPGYILLDDNRSCQDINECEHRNH 297
Query: 240 PCSAAQFCKNANGSYTCEE-----------CDSSCVGCTGEGPGNCKE 276
C+ Q C N G + C + D+ C+ C E PG C++
Sbjct: 298 TCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCM-CPAENPG-CRD 343
Score = 42.4 bits (98), Expect = 6e-04
Identities = 20/51 (39%), Positives = 30/51 (58%), Gaps = 4/51 (7%)
Query: 271 PGNCK-ECISGYA--REHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCV 318
PGN + +C +G+ R+ GQC D+DEC + C R + C N G Y+C+
Sbjct: 20 PGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEAC-RGDMMCVNQNGGYLCI 69
>gi|51873053 fibulin 2 isoform a precursor [Homo sapiens]
Length = 1231
Score = 76.6 bits (187), Expect = 3e-14
Identities = 52/176 (29%), Positives = 75/176 (42%), Gaps = 35/176 (19%)
Query: 180 CMDGYFSSLRNETHSICTACDESCKTCSG-------LTNRDCGE---CEVGWVLDEGACV 229
C DGY + + I C TCS L + C + CE G+ L +G C
Sbjct: 752 CADGYILNAHRKCVDI-NECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECE 810
Query: 230 DVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGYARE-HGQC 288
DVDECA C C+N GS+ C+ + C+ G+ ++ G C
Sbjct: 811 DVDECAMGTHTCQPGFLCQNTKGSFYCQA---------------RQRCMDGFLQDPEGNC 855
Query: 289 ADVDECSLAEKTCVRKNENCYNTPGSYVC-----VCPDGFEETEDA--CVPPAEAE 337
D++EC+ + C R +C NT GSY C +C G+ ++D CV E E
Sbjct: 856 VDINECTSLSEPC-RPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECE 910
Score = 67.8 bits (164), Expect = 1e-11
Identities = 55/172 (31%), Positives = 73/172 (42%), Gaps = 43/172 (25%)
Query: 199 CDESCKTCSGLTNRDCGECEVGWVL--DEGACVDVDECAAEPPPCSAAQFCKNANGSYTC 256
C + C T G + C C G+ + D +C D DEC CS QFC N GS+ C
Sbjct: 689 CKQVCSTVGG--SAICS-CFPGYAIMADGVSCEDQDECLMGAHDCSRRQFCVNTLGSFYC 745
Query: 257 ----------------------EECDSSCVGCT-GE------GPGNCKE---CISGYARE 284
EC + C+ GE G +C + C GYA +
Sbjct: 746 VNHTVLCADGYILNAHRKCVDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALK 805
Query: 285 HGQCADVDECSLAEKTCVRKNENCYNTPGSYVCV----CPDGF-EETEDACV 331
G+C DVDEC++ TC + C NT GS+ C C DGF ++ E CV
Sbjct: 806 DGECEDVDECAMGTHTC-QPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCV 856
Score = 62.8 bits (151), Expect = 5e-10
Identities = 55/186 (29%), Positives = 74/186 (39%), Gaps = 42/186 (22%)
Query: 180 CMDGYFSSLRNETHSI--CTACDESCKTCSGLTN--------RDCGECEVGW-VLDEGA- 227
CMDG+ I CT+ E C+ N R+ C G+ D+G
Sbjct: 843 CMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTK 902
Query: 228 CVDVDECAAEPPPCSAAQFCKNANGSYTCE-----ECDSSCVGCTG-----EGPGN-CK- 275
CVDV+EC C Q C N GSY C+ + D+ GC PG C+
Sbjct: 903 CVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQH 962
Query: 276 -----------ECISGY--AREHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDG 322
C SG+ A + +C DV+EC R ++ C N GSY C C G
Sbjct: 963 TCENTLGSYRCSCASGFLLAADGKRCEDVNECE-----AQRCSQECANIYGSYQCYCRQG 1017
Query: 323 FEETED 328
++ ED
Sbjct: 1018 YQLAED 1023
Score = 60.1 bits (144), Expect = 3e-09
Identities = 55/186 (29%), Positives = 71/186 (38%), Gaps = 48/186 (25%)
Query: 148 CSGNGHCSGDG----SRQGDGSCRCHMGYQ----GPLCTDCMDGYFSSLRNETHSICTAC 199
C H G+G + G C C G+Q G C D + + S R C
Sbjct: 909 CETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGR--------LC 960
Query: 200 DESCKTCSGLTNRDCGECEVGWVL--DEGACVDVDECAAEPPPCSAAQFCKNANGSYTCE 257
+C+ G C G++L D C DV+EC A+ CS Q C N GSY C
Sbjct: 961 QHTCENTLGSYRCSCAS---GFLLAADGKRCEDVNECEAQR--CS--QECANIYGSYQCY 1013
Query: 258 ECDSSCVGCTGEGPGNCKECISGY--AREHGQCADVDECSLAEKTCVRKNENCYNTPGSY 315
C GY A + C D+DEC A+ + C N PGSY
Sbjct: 1014 -------------------CRQGYQLAEDGHTCTDIDEC--AQGAGILCTFRCLNVPGSY 1052
Query: 316 VCVCPD 321
C CP+
Sbjct: 1053 QCACPE 1058
Score = 57.4 bits (137), Expect = 2e-08
Identities = 59/206 (28%), Positives = 74/206 (35%), Gaps = 36/206 (17%)
Query: 130 PGTYGPDCLACQGGSQRPCSGNG-----HCSGDGSRQGDGSCRCHMGYQGPLCTDCMDGY 184
PG+Y DC A G QR G G C R +C +G C
Sbjct: 926 PGSYRCDCKA---GFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLA 982
Query: 185 FSSLRNETHSICTA--CDESCKTCSGLTNRDCGECEVGWVLDEGA--CVDVDECAAEPPP 240
R E + C A C + C G + C C G+ L E C D+DECA
Sbjct: 983 ADGKRCEDVNECEAQRCSQECANIYG--SYQC-YCRQGYQLAEDGHTCTDIDECAQGAGI 1039
Query: 241 CSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGYAREHGQCADVDECSLAEKT 300
+ C N GSY C C T G C DVDEC+L
Sbjct: 1040 LCTFR-CLNVPGSYQCA-CPEQGYTMTANGRS---------------CKDVDECALGTHN 1082
Query: 301 CVRKNENCYNTPGSYVCV---CPDGF 323
C + E C+N GS+ C+ CP +
Sbjct: 1083 C-SEAETCHNIQGSFRCLRFECPPNY 1107
Score = 46.6 bits (109), Expect = 3e-05
Identities = 45/170 (26%), Positives = 53/170 (31%), Gaps = 38/170 (22%)
Query: 114 DLFEWFCVKTLKVCCSPG---------TYGPDCLACQGG-----SQRPCSGNGHCSGDGS 159
D F C+ + SPG T G +C G + C C
Sbjct: 940 DAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQRC 999
Query: 160 RQ------GDGSCRCHMGYQ----GPLCTD---CMDGYFSSLRNETHSICTACDESCKTC 206
Q G C C GYQ G CTD C G C C
Sbjct: 1000 SQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQG-----------AGILCTFRCLNV 1048
Query: 207 SGLTNRDCGECEVGWVLDEGACVDVDECAAEPPPCSAAQFCKNANGSYTC 256
G C E + +C DVDECA CS A+ C N GS+ C
Sbjct: 1049 PGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRC 1098
Score = 32.3 bits (72), Expect = 0.66
Identities = 19/57 (33%), Positives = 24/57 (42%), Gaps = 2/57 (3%)
Query: 290 DVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFEETEDACVPPAEAEATEGESPTQ 346
D DEC L + C NT GSY C C GF +D E + E+P +
Sbjct: 604 DQDECLLLPGELCQ--HLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQE 658
Score = 30.4 bits (67), Expect = 2.5
Identities = 41/154 (26%), Positives = 60/154 (38%), Gaps = 28/154 (18%)
Query: 217 CEVG--WVLDEGACVDVDECAAEPPPCSAAQFCKNANGSYTCEE-CDSSCVG------CT 267
C G W +D C+++ E E C AQ ++ SY E+ C + +G C
Sbjct: 446 CAAGQQWAIDNDECLEIPESGTEDNVCRTAQ--RHCCVSYLQEKSCMAGVLGAKEGETCG 503
Query: 268 GEGPGNCKECISGYAREHGQCADVDECSLAEKTCVRKNENCYNTPG-SYVC-----VCPD 321
E +C IS Y QC D C L + + ++C + P Y C C +
Sbjct: 504 AEDNDSCG--ISLYK----QCCDC--CGLGLRVRA-EGQSCESNPNLGYPCNHVMLSCCE 554
Query: 322 GFEE--TEDACVPPAEAEATEGESPTQLPSREDL 353
G E + PP A A S ++ RE L
Sbjct: 555 GEEPLIVPEVRRPPEPAAAPRRVSEAEMAGREAL 588
>gi|239755070 PREDICTED: similar to proprotein convertase
subtilisin/kexin type 5 [Homo sapiens]
Length = 853
Score = 75.9 bits (185), Expect = 5e-14
Identities = 62/233 (26%), Positives = 81/233 (34%), Gaps = 51/233 (21%)
Query: 120 CVKTLKVCCSPGTYGPDCLACQGG----SQRPCSGNGHCSGDGSRQGDG-SCR-CH---- 169
C K+ C S GT C CQ G + C N CS D C+ CH
Sbjct: 414 CHKSCLTCSSSGT----CTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCKPCHVKCF 469
Query: 170 --MGYQGPLCT---------------DCMDGYFSSLRNETHSICTACDESCKTCSGLTNR 212
MG C DC +GY++ +E + C C SC+TC G +R
Sbjct: 470 HCMGPAEDQCQTCPMNSLLLNTTCVKDCPEGYYA---DEDSNRCAHCHSSCRTCEGRHSR 526
Query: 213 DCGECEVGWVLDEGACVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPG 272
C C GW C+ C + N+ G CE C+ SC GC G P
Sbjct: 527 QCHSCRPGWFQLGKECL---------LQCREGYYADNSTG--RCERCNRSCKGCQGPRPT 575
Query: 273 NCKEC------ISGYAREHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCVC 319
+C C + H C D + +TC R + C G C
Sbjct: 576 DCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHPTCDQCKGKGALNC 628
Score = 60.8 bits (146), Expect = 2e-09
Identities = 67/286 (23%), Positives = 94/286 (32%), Gaps = 96/286 (33%)
Query: 116 FEWFCVKTLKVCCSPGTYGP--DCLACQGGSQRPCSGNG-HCSGDGSRQGDGSC--RCHM 170
F+ C KT C TY +C AC C NG + +G GSC +C
Sbjct: 56 FDHHCYKT----CPEKTYSEAVECKACDSNCSS-CDQNGCYWCEEGFFLLGGSCVRKCGP 110
Query: 171 GYQGPLCTDCMDGYFSSLRNETHSICTACDESCKTCSGLTNRDCGECEVGWVLDEGACVD 230
G+ G ++ C +C +C+TC+G + +C C+ G L G CV
Sbjct: 111 GFYG---------------DQEMGECESCHRACETCTGPGHDECSSCQEGLQLLRGMCVH 155
Query: 231 VDECAAEP----------PPCSAAQFCKNANGSYT------------------------- 255
+ E PC ++ CK NGS T
Sbjct: 156 ATKTQEEGKFWNDILRKLQPCHSS--CKTCNGSATLCTSCPKGAYLLAQACVSSCPQGTW 213
Query: 256 -------CEECDSSCVGCTGEG----------------PGNC-KECISGYAREHGQCADV 291
CE C +C C+G G C +C G E G C
Sbjct: 214 PSVRSGSCENCTEACAICSGADLCKKCQMQPGHPLFLHEGRCYSKCPEGSYAEDGIC--- 270
Query: 292 DECSLAEKTCVRKNENCYNTPGSYVC-------VCPDGFEETEDAC 330
+ CS +TC NC++ G +V CP+ E C
Sbjct: 271 ERCSSPCRTCEGNATNCHSCEGGHVLHHGVCQENCPERHVAVEGVC 316
Score = 47.0 bits (110), Expect = 3e-05
Identities = 42/191 (21%), Positives = 64/191 (33%), Gaps = 48/191 (25%)
Query: 172 YQGPLCTDCMDGYFSSLRNETHSICTACDESCKTCSGLTNRDCGECEVGWVLDEGACVD- 230
++G + C +G ++ IC C C+TC G +C CE G VL G C +
Sbjct: 251 HEGRCYSKCPEGSYAE-----DGICERCSSPCRTCEGNAT-NCHSCEGGHVLHHGVCQEN 304
Query: 231 -----------VDECAAEPPPCSAAQFCKNAN--------------------GSYTCEEC 259
C C + CK S+ C C
Sbjct: 305 CPERHVAVEGVCKHCPEMCQDCIHEKTCKECMPEFFLHDDMCHQSCPRGFYADSHHCVPC 364
Query: 260 DSSCVGCTGEGPGNCKECI-SGYAREHGQCADVDECSLA------EKTCVRKNENCYNTP 312
C+ C+G +C+ C+ S + G C ++EC K C +++C
Sbjct: 365 HKDCLECSGPKADDCELCLESSWVLYDGLC--LEECPAGTYYEKQTKECRDCHKSCLTCS 422
Query: 313 GSYVC-VCPDG 322
S C C G
Sbjct: 423 SSGTCTTCQKG 433
Score = 46.2 bits (108), Expect = 4e-05
Identities = 56/223 (25%), Positives = 74/223 (33%), Gaps = 55/223 (24%)
Query: 83 CESSDFECNQMLEAQEEHLEAWWLQLKSE---------YPDLFEWFCVKTLKVCCSPGTY 133
C SS C Q W QL E Y D C + + C G
Sbjct: 513 CHSSCRTCEGRHSRQCHSCRPGWFQLGKECLLQCREGYYADNSTGRCERCNRSC--KGCQ 570
Query: 134 GP---DCLAC---------QGGSQRPCSGNGH-----------------CSGDGSRQGDG 164
GP DCL+C +G R C + + C G G+
Sbjct: 571 GPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHPTCDQCKGKGALNCL- 629
Query: 165 SCRCHMGYQGPLCT-DCMDGYFSSLRNETHSICTACDESCKTCSGLTNRDCGECEVGWVL 223
SC G +CT DC+ G + E + C C ESC C G ++C C VL
Sbjct: 630 SCVWSYHLMGGICTSDCLVGEYRVGEGEKFN-CEKCHESCMECKGPGAKNCTLCPANLVL 688
Query: 224 --DEGACVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCV 264
DE C+ C P SA + C C++ C+
Sbjct: 689 HMDESHCL---HCCNTSDPPSAQECC-------DCQDTTDECI 721
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.455
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,366,753
Number of Sequences: 37866
Number of extensions: 1026317
Number of successful extensions: 9651
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 174
Number of HSP's successfully gapped in prelim test: 320
Number of HSP's that attempted gapping in prelim test: 5920
Number of HSP's gapped (non-prelim): 2167
length of query: 353
length of database: 18,247,518
effective HSP length: 103
effective length of query: 250
effective length of database: 14,347,320
effective search space: 3586830000
effective search space used: 3586830000
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.