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Search of human proteins with 20336248
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|20336248 proprotein convertase subtilisin/kexin type 7
preproprotein [Homo sapiens]
(785 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|20336248 proprotein convertase subtilisin/kexin type 7 prepro... 1635 0.0
gi|20336182 paired basic amino acid cleaving system 4 isoform g ... 462 e-130
gi|4505577 paired basic amino acid cleaving system 4 isoform a p... 462 e-130
gi|20336184 paired basic amino acid cleaving system 4 isoform h ... 461 e-129
gi|20336180 paired basic amino acid cleaving system 4 isoform b ... 461 e-129
gi|20336246 proprotein convertase subtilisin/kexin type 5 prepro... 457 e-128
gi|20336188 paired basic amino acid cleaving system 4 isoform e ... 446 e-125
gi|27894285 paired basic amino acid cleaving system 4 isoform f ... 446 e-125
gi|20336190 paired basic amino acid cleaving system 4 isoform d ... 446 e-125
gi|4505579 furin preproprotein [Homo sapiens] 427 e-119
gi|20336242 proprotein convertase subtilisin/kexin type 1 prepro... 425 e-119
gi|76443679 proprotein convertase subtilisin/kexin type 4 [Homo ... 422 e-118
gi|20336244 proprotein convertase subtilisin/kexin type 2 [Homo ... 377 e-104
gi|20336186 paired basic amino acid cleaving system 4 isoform c ... 355 7e-98
gi|31317307 proprotein convertase subtilisin/kexin type 9 prepro... 36 0.12
gi|65288071 tensin 3 [Homo sapiens] 35 0.35
gi|4506775 membrane-bound transcription factor site-1 protease p... 34 0.46
gi|20070331 oxysterol binding protein-like 9 isoform e [Homo sap... 32 1.7
gi|22547176 oxysterol binding protein-like 9 isoform f [Homo sap... 32 1.7
gi|22547173 oxysterol binding protein-like 9 isoform d [Homo sap... 32 1.7
gi|22547171 oxysterol binding protein-like 9 isoform c [Homo sap... 32 1.7
gi|22547169 oxysterol binding protein-like 9 isoform b [Homo sap... 32 1.7
gi|22547167 oxysterol binding protein-like 9 isoform a [Homo sap... 32 1.7
gi|22547165 oxysterol binding protein-like 9 isoform a [Homo sap... 32 1.7
gi|33286442 BCL6 co-repressor-like 1 [Homo sapiens] 31 3.9
gi|21735548 centrosomal protein 2 [Homo sapiens] 31 5.1
gi|214830451 sequestosome 1 isoform 2 [Homo sapiens] 31 5.1
gi|214830438 sequestosome 1 isoform 2 [Homo sapiens] 31 5.1
gi|4505571 sequestosome 1 isoform 1 [Homo sapiens] 31 5.1
gi|94536852 transmembrane cochlear-expressed protein 2 [Homo sap... 31 5.1
>gi|20336248 proprotein convertase subtilisin/kexin type 7
preproprotein [Homo sapiens]
Length = 785
Score = 1635 bits (4233), Expect = 0.0
Identities = 785/785 (100%), Positives = 785/785 (100%)
Query: 1 MPKGRQKVPHLDAPLGLPTCLWLELAGLFLLVPWVMGLAGTGGPDGQGTGGPSWAVHLES 60
MPKGRQKVPHLDAPLGLPTCLWLELAGLFLLVPWVMGLAGTGGPDGQGTGGPSWAVHLES
Sbjct: 1 MPKGRQKVPHLDAPLGLPTCLWLELAGLFLLVPWVMGLAGTGGPDGQGTGGPSWAVHLES 60
Query: 61 LEGDGEEETLEQQADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQVEAV 120
LEGDGEEETLEQQADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQVEAV
Sbjct: 61 LEGDGEEETLEQQADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQVEAV 120
Query: 121 LAGHEAVRWHSEQRLLRRAKRSVHFNDPKYPQQWHLNNRRSPGRDINVTGVWERNVTGRG 180
LAGHEAVRWHSEQRLLRRAKRSVHFNDPKYPQQWHLNNRRSPGRDINVTGVWERNVTGRG
Sbjct: 121 LAGHEAVRWHSEQRLLRRAKRSVHFNDPKYPQQWHLNNRRSPGRDINVTGVWERNVTGRG 180
Query: 181 VTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVP 240
VTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVP
Sbjct: 181 VTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVP 240
Query: 241 NNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGP 300
NNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGP
Sbjct: 241 NNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGP 300
Query: 301 HQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRM 360
HQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRM
Sbjct: 301 HQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRM 360
Query: 361 PFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALML 420
PFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALML
Sbjct: 361 PFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALML 420
Query: 421 QVRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWT 480
QVRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWT
Sbjct: 421 QVRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWT 480
Query: 481 SVPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRG 540
SVPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRG
Sbjct: 481 SVPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRG 540
Query: 541 SLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDESF 600
SLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDESF
Sbjct: 541 SLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDESF 600
Query: 601 QVGILRQWQLTLYGSVWSAVDIRDRQRLLESAMSGKYLHDDFALPCPPGLKIPEEDGYTI 660
QVGILRQWQLTLYGSVWSAVDIRDRQRLLESAMSGKYLHDDFALPCPPGLKIPEEDGYTI
Sbjct: 601 QVGILRQWQLTLYGSVWSAVDIRDRQRLLESAMSGKYLHDDFALPCPPGLKIPEEDGYTI 660
Query: 661 TPNTLKTLVLVGCFTVFWTVYYMLEVYLSQRNVASNQVCRSGPCHWPHRSRKAKEEGTEL 720
TPNTLKTLVLVGCFTVFWTVYYMLEVYLSQRNVASNQVCRSGPCHWPHRSRKAKEEGTEL
Sbjct: 661 TPNTLKTLVLVGCFTVFWTVYYMLEVYLSQRNVASNQVCRSGPCHWPHRSRKAKEEGTEL 720
Query: 721 ESVPLCSSKDPDEVETESRGPPTTSDLLAPDLLEQGDWSLSQNKSALDCPHQHLDVPHGK 780
ESVPLCSSKDPDEVETESRGPPTTSDLLAPDLLEQGDWSLSQNKSALDCPHQHLDVPHGK
Sbjct: 721 ESVPLCSSKDPDEVETESRGPPTTSDLLAPDLLEQGDWSLSQNKSALDCPHQHLDVPHGK 780
Query: 781 EEQIC 785
EEQIC
Sbjct: 781 EEQIC 785
>gi|20336182 paired basic amino acid cleaving system 4 isoform g
preproprotein [Homo sapiens]
Length = 975
Score = 462 bits (1188), Expect = e-130
Identities = 263/622 (42%), Positives = 354/622 (56%), Gaps = 31/622 (4%)
Query: 73 QADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQ-VEAVLAGHEAVRWHS 131
+AD +A A G +N G+IG L+ +Y F H + + + L V+W
Sbjct: 84 EADRVAAAHGYLNLGQIGNLEDYYHFY----HSKTFKRSTLSSRGPHTFLRMDPQVKWLQ 139
Query: 132 EQRLLRRAKRSV-------HFNDPKYPQQWHLNNRRSPGR---DINVTGVWERNVTGRGV 181
+Q + RR KR V +FNDP + W+L+ R ++NV W+R TG+ V
Sbjct: 140 QQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNV 199
Query: 182 TVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPN 241
V ++DDG+E D+APNY SYD+N ND DP P D N N HGTRCAGE+AA N
Sbjct: 200 VVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASAN 259
Query: 242 NSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPH 301
NS+C VG+AY ++I GIR+LDG +TD +EA + DIYS SWGPDDDGKTVDGP
Sbjct: 260 NSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPG 319
Query: 302 QLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMP 361
+L K A ++G+ GRQG GSIFV ASGNGG+ D C+ DGY NSIYT+++ + E G P
Sbjct: 320 RLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKP 379
Query: 362 FYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQ 421
+Y EECAS LA T+S G R IVTTD + CT+GHTGTS +AP+ AG+IAL L+
Sbjct: 380 WYLEECASTLATTYSSGAFYERKIVTTDLRQR----CTDGHTGTSVSAPMVAGIIALALE 435
Query: 422 VRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTS 481
LTWRDVQH++V T+ + ++W N AG SH +GFGL++A LV AK WT+
Sbjct: 436 ANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTA 495
Query: 482 VPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGS 541
VP V+ K ++IP + + + LEHV V SI+HPRRG
Sbjct: 496 VPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGD 555
Query: 542 LELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDE--- 598
L++ L PSG S + A R +D GF +W F TV CWGE+A G + L I+D+ +
Sbjct: 556 LQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRN 615
Query: 599 SFQVGILRQWQLTLYGSVWSAVDI----RDRQRLLESAMSGKYLHDDFALPCPPGLKIPE 654
+ G L++W L LYG+ + R R+LE +S L A P +++PE
Sbjct: 616 PEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLE--LSAPELEPPKAALSPSQVEVPE 673
Query: 655 -EDGYTI--TPNTLKTLVLVGC 673
E+ YT TP + L C
Sbjct: 674 DEEDYTAQSTPGSANILQTSVC 695
>gi|4505577 paired basic amino acid cleaving system 4 isoform a
preproprotein [Homo sapiens]
Length = 969
Score = 462 bits (1188), Expect = e-130
Identities = 263/622 (42%), Positives = 354/622 (56%), Gaps = 31/622 (4%)
Query: 73 QADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQ-VEAVLAGHEAVRWHS 131
+AD +A A G +N G+IG L+ +Y F H + + + L V+W
Sbjct: 84 EADRVAAAHGYLNLGQIGNLEDYYHFY----HSKTFKRSTLSSRGPHTFLRMDPQVKWLQ 139
Query: 132 EQRLLRRAKRSV-------HFNDPKYPQQWHLNNRRSPGR---DINVTGVWERNVTGRGV 181
+Q + RR KR V +FNDP + W+L+ R ++NV W+R TG+ V
Sbjct: 140 QQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNV 199
Query: 182 TVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPN 241
V ++DDG+E D+APNY SYD+N ND DP P D N N HGTRCAGE+AA N
Sbjct: 200 VVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASAN 259
Query: 242 NSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPH 301
NS+C VG+AY ++I GIR+LDG +TD +EA + DIYS SWGPDDDGKTVDGP
Sbjct: 260 NSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPG 319
Query: 302 QLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMP 361
+L K A ++G+ GRQG GSIFV ASGNGG+ D C+ DGY NSIYT+++ + E G P
Sbjct: 320 RLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKP 379
Query: 362 FYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQ 421
+Y EECAS LA T+S G R IVTTD + CT+GHTGTS +AP+ AG+IAL L+
Sbjct: 380 WYLEECASTLATTYSSGAFYERKIVTTDLRQR----CTDGHTGTSVSAPMVAGIIALALE 435
Query: 422 VRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTS 481
LTWRDVQH++V T+ + ++W N AG SH +GFGL++A LV AK WT+
Sbjct: 436 ANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTA 495
Query: 482 VPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGS 541
VP V+ K ++IP + + + LEHV V SI+HPRRG
Sbjct: 496 VPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGD 555
Query: 542 LELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDE--- 598
L++ L PSG S + A R +D GF +W F TV CWGE+A G + L I+D+ +
Sbjct: 556 LQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRN 615
Query: 599 SFQVGILRQWQLTLYGSVWSAVDI----RDRQRLLESAMSGKYLHDDFALPCPPGLKIPE 654
+ G L++W L LYG+ + R R+LE +S L A P +++PE
Sbjct: 616 PEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLE--LSAPELEPPKAALSPSQVEVPE 673
Query: 655 -EDGYTI--TPNTLKTLVLVGC 673
E+ YT TP + L C
Sbjct: 674 DEEDYTAQSTPGSANILQTSVC 695
>gi|20336184 paired basic amino acid cleaving system 4 isoform h
preproprotein [Homo sapiens]
Length = 962
Score = 461 bits (1186), Expect = e-129
Identities = 259/606 (42%), Positives = 349/606 (57%), Gaps = 29/606 (4%)
Query: 73 QADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQ-VEAVLAGHEAVRWHS 131
+AD +A A G +N G+IG L+ +Y F H + + + L V+W
Sbjct: 84 EADRVAAAHGYLNLGQIGNLEDYYHFY----HSKTFKRSTLSSRGPHTFLRMDPQVKWLQ 139
Query: 132 EQRLLRRAKRSV-------HFNDPKYPQQWHLNNRRSPGR---DINVTGVWERNVTGRGV 181
+Q + RR KR V +FNDP + W+L+ R ++NV W+R TG+ V
Sbjct: 140 QQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNV 199
Query: 182 TVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPN 241
V ++DDG+E D+APNY SYD+N ND DP P D N N HGTRCAGE+AA N
Sbjct: 200 VVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASAN 259
Query: 242 NSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPH 301
NS+C VG+AY ++I GIR+LDG +TD +EA + DIYS SWGPDDDGKTVDGP
Sbjct: 260 NSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPG 319
Query: 302 QLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMP 361
+L K A ++G+ GRQG GSIFV ASGNGG+ D C+ DGY NSIYT+++ + E G P
Sbjct: 320 RLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKP 379
Query: 362 FYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQ 421
+Y EECAS LA T+S G R IVTTD + CT+GHTGTS +AP+ AG+IAL L+
Sbjct: 380 WYLEECASTLATTYSSGAFYERKIVTTDLRQR----CTDGHTGTSVSAPMVAGIIALALE 435
Query: 422 VRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTS 481
LTWRDVQH++V T+ + ++W N AG SH +GFGL++A LV AK WT+
Sbjct: 436 ANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTA 495
Query: 482 VPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGS 541
VP V+ K ++IP + + + LEHV V SI+HPRRG
Sbjct: 496 VPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGD 555
Query: 542 LELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDE--- 598
L++ L PSG S + A R +D GF +W F TV CWGE+A G + L I+D+ +
Sbjct: 556 LQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRN 615
Query: 599 SFQVGILRQWQLTLYGSVWSAVDI----RDRQRLLESAMSGKYLHDDFALPCPPGLKIPE 654
+ G L++W L LYG+ + R R+LE +S L A P +++PE
Sbjct: 616 PEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLE--LSAPELEPPKAALSPSQVEVPE 673
Query: 655 -EDGYT 659
E+ YT
Sbjct: 674 DEEDYT 679
>gi|20336180 paired basic amino acid cleaving system 4 isoform b
preproprotein [Homo sapiens]
Length = 956
Score = 461 bits (1186), Expect = e-129
Identities = 259/606 (42%), Positives = 349/606 (57%), Gaps = 29/606 (4%)
Query: 73 QADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQ-VEAVLAGHEAVRWHS 131
+AD +A A G +N G+IG L+ +Y F H + + + L V+W
Sbjct: 84 EADRVAAAHGYLNLGQIGNLEDYYHFY----HSKTFKRSTLSSRGPHTFLRMDPQVKWLQ 139
Query: 132 EQRLLRRAKRSV-------HFNDPKYPQQWHLNNRRSPGR---DINVTGVWERNVTGRGV 181
+Q + RR KR V +FNDP + W+L+ R ++NV W+R TG+ V
Sbjct: 140 QQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNV 199
Query: 182 TVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPN 241
V ++DDG+E D+APNY SYD+N ND DP P D N N HGTRCAGE+AA N
Sbjct: 200 VVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASAN 259
Query: 242 NSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPH 301
NS+C VG+AY ++I GIR+LDG +TD +EA + DIYS SWGPDDDGKTVDGP
Sbjct: 260 NSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPG 319
Query: 302 QLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMP 361
+L K A ++G+ GRQG GSIFV ASGNGG+ D C+ DGY NSIYT+++ + E G P
Sbjct: 320 RLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKP 379
Query: 362 FYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQ 421
+Y EECAS LA T+S G R IVTTD + CT+GHTGTS +AP+ AG+IAL L+
Sbjct: 380 WYLEECASTLATTYSSGAFYERKIVTTDLRQR----CTDGHTGTSVSAPMVAGIIALALE 435
Query: 422 VRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTS 481
LTWRDVQH++V T+ + ++W N AG SH +GFGL++A LV AK WT+
Sbjct: 436 ANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTA 495
Query: 482 VPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGS 541
VP V+ K ++IP + + + LEHV V SI+HPRRG
Sbjct: 496 VPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGD 555
Query: 542 LELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDE--- 598
L++ L PSG S + A R +D GF +W F TV CWGE+A G + L I+D+ +
Sbjct: 556 LQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRN 615
Query: 599 SFQVGILRQWQLTLYGSVWSAVDI----RDRQRLLESAMSGKYLHDDFALPCPPGLKIPE 654
+ G L++W L LYG+ + R R+LE +S L A P +++PE
Sbjct: 616 PEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLE--LSAPELEPPKAALSPSQVEVPE 673
Query: 655 -EDGYT 659
E+ YT
Sbjct: 674 DEEDYT 679
>gi|20336246 proprotein convertase subtilisin/kexin type 5
preproprotein [Homo sapiens]
Length = 913
Score = 457 bits (1177), Expect = e-128
Identities = 248/598 (41%), Positives = 349/598 (58%), Gaps = 30/598 (5%)
Query: 73 QADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQ-VEAVLAGHEAVRWHS 131
+A+ +A G +N G+IG L+ +Y F H ++ I + + ++ V W
Sbjct: 49 EANRIASKYGFINIGQIGALKDYYHFY----HSRTIKRSVISSRGTHSFISMEPKVEWIQ 104
Query: 132 EQRLLRRAKR--------SVHFNDPKYPQQWHLN---NRRSPGRDINVTGVWERNVTGRG 180
+Q + +R KR S +FNDPK+P W+++ N D+N+ G W+R TG+
Sbjct: 105 QQVVKKRTKRDYDFSRAQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKN 164
Query: 181 VTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVP 240
+ V ++DDG+E T D+ NY S D+N ND DPMP D N N HGTRCAGE+AA
Sbjct: 165 IVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAA 224
Query: 241 NNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGP 300
NNS C VG+A+ ++I G+R+LDG +TD +EA + + + Q IYS SWGPDDDGKTVDGP
Sbjct: 225 NNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGP 284
Query: 301 HQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRM 360
L + A ++GV GR+G GS+FV ASGNGG+ D+C+ DGY NSIYT++I + E G+
Sbjct: 285 APLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKK 344
Query: 361 PFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALML 420
P+Y EEC+S LA T+S G+ + I+TTD + CT+ HTGTSA+AP+AAG+IAL L
Sbjct: 345 PWYLEECSSTLATTYSSGESYDKKIITTDLRQR----CTDNHTGTSASAPMAAGIIALAL 400
Query: 421 QVRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWT 480
+ P LTWRDVQH+IV T+ +W TN AGF SH +GFGL++A +V A+ WT
Sbjct: 401 EANPFLTWRDVQHVIVRTSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWT 460
Query: 481 SVPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRG 540
+VP V ++ K I + + D + LEHV V ++ITHPRRG
Sbjct: 461 TVPRQHVCVESTDRQIKTIRPNSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRG 520
Query: 541 SLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDE-- 598
L + L PSG S + A R D GF +W F T+ CWGERA G + L + D +
Sbjct: 521 DLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLR 580
Query: 599 SFQV-GILRQWQLTLYGSVWSAVDIRDR----QRLLESAM---SGKYLHDDFALPCPP 648
+F+ G L++W L LYG+ + +R S + + Y +D+A PC P
Sbjct: 581 NFKTPGKLKEWSLVLYGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDP 638
>gi|20336188 paired basic amino acid cleaving system 4 isoform e
preproprotein [Homo sapiens]
Length = 623
Score = 446 bits (1148), Expect = e-125
Identities = 239/534 (44%), Positives = 317/534 (59%), Gaps = 19/534 (3%)
Query: 73 QADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQ-VEAVLAGHEAVRWHS 131
+AD +A A G +N G+IG L+ +Y F H + + + L V+W
Sbjct: 84 EADRVAAAHGYLNLGQIGNLEDYYHFY----HSKTFKRSTLSSRGPHTFLRMDPQVKWLQ 139
Query: 132 EQRLLRRAKRSV-------HFNDPKYPQQWHLNNRRSPGR---DINVTGVWERNVTGRGV 181
+Q + RR KR V +FNDP + W+L+ R ++NV W+R TG+ V
Sbjct: 140 QQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNV 199
Query: 182 TVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPN 241
V ++DDG+E D+APNY SYD+N ND DP P D N N HGTRCAGE+AA N
Sbjct: 200 VVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASAN 259
Query: 242 NSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPH 301
NS+C VG+AY ++I GIR+LDG +TD +EA + DIYS SWGPDDDGKTVDGP
Sbjct: 260 NSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPG 319
Query: 302 QLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMP 361
+L K A ++G+ GRQG GSIFV ASGNGG+ D C+ DGY NSIYT+++ + E G P
Sbjct: 320 RLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKP 379
Query: 362 FYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQ 421
+Y EECAS LA T+S G R IVTTD + CT+GHTGTS +AP+ AG+IAL L+
Sbjct: 380 WYLEECASTLATTYSSGAFYERKIVTTDLRQR----CTDGHTGTSVSAPMVAGIIALALE 435
Query: 422 VRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTS 481
LTWRDVQH++V T+ + ++W N AG SH +GFGL++A LV AK WT+
Sbjct: 436 ANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTA 495
Query: 482 VPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGS 541
VP V+ K ++IP + + + LEHV V SI+HPRRG
Sbjct: 496 VPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGD 555
Query: 542 LELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDV 595
L++ L PSG S + A R +D GF +W F TV CWGE+A G + L I+D+
Sbjct: 556 LQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDL 609
>gi|27894285 paired basic amino acid cleaving system 4 isoform f
preproprotein [Homo sapiens]
Length = 664
Score = 446 bits (1148), Expect = e-125
Identities = 239/534 (44%), Positives = 317/534 (59%), Gaps = 19/534 (3%)
Query: 73 QADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQ-VEAVLAGHEAVRWHS 131
+AD +A A G +N G+IG L+ +Y F H + + + L V+W
Sbjct: 84 EADRVAAAHGYLNLGQIGNLEDYYHFY----HSKTFKRSTLSSRGPHTFLRMDPQVKWLQ 139
Query: 132 EQRLLRRAKRSV-------HFNDPKYPQQWHLNNRRSPGR---DINVTGVWERNVTGRGV 181
+Q + RR KR V +FNDP + W+L+ R ++NV W+R TG+ V
Sbjct: 140 QQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNV 199
Query: 182 TVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPN 241
V ++DDG+E D+APNY SYD+N ND DP P D N N HGTRCAGE+AA N
Sbjct: 200 VVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASAN 259
Query: 242 NSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPH 301
NS+C VG+AY ++I GIR+LDG +TD +EA + DIYS SWGPDDDGKTVDGP
Sbjct: 260 NSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPG 319
Query: 302 QLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMP 361
+L K A ++G+ GRQG GSIFV ASGNGG+ D C+ DGY NSIYT+++ + E G P
Sbjct: 320 RLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKP 379
Query: 362 FYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQ 421
+Y EECAS LA T+S G R IVTTD + CT+GHTGTS +AP+ AG+IAL L+
Sbjct: 380 WYLEECASTLATTYSSGAFYERKIVTTDLRQR----CTDGHTGTSVSAPMVAGIIALALE 435
Query: 422 VRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTS 481
LTWRDVQH++V T+ + ++W N AG SH +GFGL++A LV AK WT+
Sbjct: 436 ANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTA 495
Query: 482 VPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGS 541
VP V+ K ++IP + + + LEHV V SI+HPRRG
Sbjct: 496 VPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGD 555
Query: 542 LELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDV 595
L++ L PSG S + A R +D GF +W F TV CWGE+A G + L I+D+
Sbjct: 556 LQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDL 609
>gi|20336190 paired basic amino acid cleaving system 4 isoform d
preproprotein [Homo sapiens]
Length = 652
Score = 446 bits (1148), Expect = e-125
Identities = 239/534 (44%), Positives = 317/534 (59%), Gaps = 19/534 (3%)
Query: 73 QADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQ-VEAVLAGHEAVRWHS 131
+AD +A A G +N G+IG L+ +Y F H + + + L V+W
Sbjct: 84 EADRVAAAHGYLNLGQIGNLEDYYHFY----HSKTFKRSTLSSRGPHTFLRMDPQVKWLQ 139
Query: 132 EQRLLRRAKRSV-------HFNDPKYPQQWHLNNRRSPGR---DINVTGVWERNVTGRGV 181
+Q + RR KR V +FNDP + W+L+ R ++NV W+R TG+ V
Sbjct: 140 QQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNV 199
Query: 182 TVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPN 241
V ++DDG+E D+APNY SYD+N ND DP P D N N HGTRCAGE+AA N
Sbjct: 200 VVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASAN 259
Query: 242 NSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPH 301
NS+C VG+AY ++I GIR+LDG +TD +EA + DIYS SWGPDDDGKTVDGP
Sbjct: 260 NSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPG 319
Query: 302 QLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMP 361
+L K A ++G+ GRQG GSIFV ASGNGG+ D C+ DGY NSIYT+++ + E G P
Sbjct: 320 RLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKP 379
Query: 362 FYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQ 421
+Y EECAS LA T+S G R IVTTD + CT+GHTGTS +AP+ AG+IAL L+
Sbjct: 380 WYLEECASTLATTYSSGAFYERKIVTTDLRQR----CTDGHTGTSVSAPMVAGIIALALE 435
Query: 422 VRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTS 481
LTWRDVQH++V T+ + ++W N AG SH +GFGL++A LV AK WT+
Sbjct: 436 ANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTA 495
Query: 482 VPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGS 541
VP V+ K ++IP + + + LEHV V SI+HPRRG
Sbjct: 496 VPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGD 555
Query: 542 LELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDV 595
L++ L PSG S + A R +D GF +W F TV CWGE+A G + L I+D+
Sbjct: 556 LQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDL 609
>gi|4505579 furin preproprotein [Homo sapiens]
Length = 794
Score = 427 bits (1097), Expect = e-119
Identities = 254/652 (38%), Positives = 355/652 (54%), Gaps = 41/652 (6%)
Query: 34 WVMGLAGT-----GGPDGQGTGGPSWAVHLESLEGDGEEETLEQQADALAQAAGLVNAGR 88
WV+ GT GQ +WAV + A+++A+ G +N G+
Sbjct: 9 WVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPA---------VANSVARKHGFLNLGQ 59
Query: 89 IGELQGHYLFVQPAGHRPALEVEAIRQQVEAVLAGHEAVRWHSEQRLLRRAKRSVHFN-- 146
I +Y F + +L R + L V+W +Q RR KR V+
Sbjct: 60 I--FGDYYHFWHRGVTKRSLSPHRPRH---SRLQREPQVQWLEQQVAKRRTKRDVYQEPT 114
Query: 147 DPKYPQQWHLNNRRSPGRDINVTGVWERNVTGRGVTVVVVDDGVEHTIQDIAPNYSPEGS 206
DPK+PQQW+L+ RD+NV W + TG G+ V ++DDG+E D+A NY P S
Sbjct: 115 DPKFPQQWYLSGVTQ--RDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGAS 172
Query: 207 YDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLDGPLT 266
+D+N DPDP P N N HGTRCAGE+AAV NN C VGVAY +RI G+R+LDG +T
Sbjct: 173 FDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVT 232
Query: 267 DSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRQGFGSIFVVA 326
D++EA + + IYS SWGP+DDGKTVDGP +L + A GV GR G GSIFV A
Sbjct: 233 DAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWA 292
Query: 327 SGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIV 386
SGNGG+ +D+CN DGY NSIYT++I + + G +P+Y+E C+S LA T+S G++ + IV
Sbjct: 293 SGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIV 352
Query: 387 TTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRR 446
TTD + CTE HTGTSA+APLAAG+IAL L+ LTWRD+QH++V T+
Sbjct: 353 TTDLRQK----CTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNA 408
Query: 447 AEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAIPQSPRSL 506
+W TN G SH +G+GLL+A +V A+ WT+V + +L E K I + L
Sbjct: 409 NDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDI---GKRL 465
Query: 507 EVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDP 566
EV V+ E + + LEH +++++ RRG L + L P G S + A R D
Sbjct: 466 EVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSA 525
Query: 567 NGFNDWTFSTVRCWGERARGTYRLVIRDVGDESFQVGILRQWQLTLYGSVWSAVDIRDRQ 626
+GFNDW F T W E G + L I + E+ G L ++ L LYG+ + +
Sbjct: 526 DGFNDWAFMTTHSWDEDPSGEWVLEIENT-SEANNYGTLTKFTLVLYGTAPEGLPVPPES 584
Query: 627 ---RLLESAMSGKYLHDDFAL-------PCPPGLKIPEEDGYTITPNTLKTL 668
+ L S+ + + F+L CPPG D + T N ++T+
Sbjct: 585 SGCKTLTSSQACVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETI 636
>gi|20336242 proprotein convertase subtilisin/kexin type 1
preproprotein [Homo sapiens]
Length = 753
Score = 425 bits (1092), Expect = e-119
Identities = 241/562 (42%), Positives = 333/562 (59%), Gaps = 29/562 (5%)
Query: 72 QQADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQVEAVLAGHEAVRWHS 131
+ A A+A+ G G+IG L+ HYLF + H A + L+ + V W
Sbjct: 44 EAASAIAEELGYDLLGQIGSLENHYLF-KHKNHPRRSRRSAFH--ITKRLSDDDRVIWAE 100
Query: 132 EQRLLRRAKRSVH-------FNDPKYPQQWHLNNRRS----PGRDINVTGVWERNVTGRG 180
+Q R+KRS FNDP + QQW+L + R P D++V VW++ +TG+G
Sbjct: 101 QQYEKERSKRSALRDSALNLFNDPMWNQQWYLQDTRMTAALPKLDLHVIPVWQKGITGKG 160
Query: 181 VTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVP 240
V + V+DDG+E DI NY PE SYD N ND DP P D N N HGTRCAGEIA
Sbjct: 161 VVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHDPFPRYDPTNENKHGTRCAGEIAMQA 220
Query: 241 NNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGP 300
NN C VGVAY S++ GIR+LDG +TD++EA + + DIYS SWGP+DDGKTV+GP
Sbjct: 221 NNHKCGVGVAYNSKVGGIRMLDGIVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTVEGP 280
Query: 301 HQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRM 360
+L + A ++GV GRQG GSIFV ASGNGG+ DNC+ DGY +SIYT++I + ++G
Sbjct: 281 GRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLS 340
Query: 361 PFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALML 420
P+YAE+C+S LA ++S GD + I + D CTE HTGTSA+APLAAG+ AL L
Sbjct: 341 PWYAEKCSSTLATSYSSGDYTDQRITSADLH----NDCTETHTGTSASAPLAAGIFALAL 396
Query: 421 QVRPCLTWRDVQHIIVFTATRYED--RRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAA-- 476
+ P LTWRD+QH++V+T + Y+ W N AG + + GFGLLNA LV+ A
Sbjct: 397 EANPNLTWRDMQHLVVWT-SEYDPLANNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADP 455
Query: 477 KIWTSVPYLASYVSPVLKENKAIPQSPRSL-EVLWNVSRMDLE--MSGLKTLEHVAVTVS 533
+ W SVP V+K+N P++ ++ EV+ + E + +K+LEHV +
Sbjct: 456 RTWRSVP---EKKECVVKDNDFEPRALKANGEVIIEIPTRACEGQENAIKSLEHVQFEAT 512
Query: 534 ITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIR 593
I + RRG L + L +G +++ A R D+ PNGF +W F +V WGE GT+ L I
Sbjct: 513 IEYSRRGDLHVTLTSAAGTSTVLLAERERDTSPNGFKNWDFMSVHTWGENPIGTWTLRIT 572
Query: 594 DVGDESFQVGILRQWQLTLYGS 615
D+ G + W+L L+G+
Sbjct: 573 DMSGRIQNEGRIVNWKLILHGT 594
>gi|76443679 proprotein convertase subtilisin/kexin type 4 [Homo
sapiens]
Length = 755
Score = 422 bits (1085), Expect = e-118
Identities = 253/648 (39%), Positives = 357/648 (55%), Gaps = 44/648 (6%)
Query: 18 PTCLWLELA-GLFLLVPWVMGLAGTGGPDGQGTGGPSWAVHLESLEGDGEEETLEQQADA 76
P LWL L L L+ P +G A P SWAV + +G+ E E L
Sbjct: 5 PIALWLRLVLALALVRPRAVGWAPVRAPIYVS----SWAVQVS--QGNREVERL------ 52
Query: 77 LAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQVEAV-LAGHEAVRWHSEQRL 135
A+ G VN G I G Y ++ HR ++ + L + V+W +Q L
Sbjct: 53 -ARKFGFVNLGPIFP-DGQYFHLR---HRGVVQQSLTPHWGHRLHLKKNPKVQWFQQQTL 107
Query: 136 LRRAKRSVHF-NDPKYPQQWHLNNRRSPGRDINVTGVWERNVTGRGVTVVVVDDGVEHTI 194
RR KRSV DP + +QW++N+ P D+++ W + ++G+G+ V V+DDG+E
Sbjct: 108 QRRVKRSVVVPTDPWFSKQWYMNSEAQP--DLSILQAWSQGLSGQGIVVSVLDDGIEKDH 165
Query: 195 QDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSR 254
D+ NY P SYD N DPDP P N HGTRCAGE+AA+ NN FC VGVA+ +R
Sbjct: 166 PDLWANYDPLASYDFNDYDPDPQPRYTPSKENRHGTRCAGEVAAMANNGFCGVGVAFNAR 225
Query: 255 IAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIA 314
I G+R+LDG +TD +EA + + Q IYS SWGP+DDG+TVDGP L + A + GV
Sbjct: 226 IGGVRMLDGTITDVIEAQSLSLQPQHIHIYSASWGPEDDGRTVDGPGILTREAFRRGVTK 285
Query: 315 GRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVT 374
GR G G++F+ ASGNGG H DNCN DGY NSI+T+++G+ ++GR+P+Y+E CAS L T
Sbjct: 286 GRGGLGTLFIWASGNGGLHYDNCNCDGYTNSIHTLSVGSTTQQGRVPWYSEACASTLTTT 345
Query: 375 FSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHI 434
+S G IVTTD GCT+ HTGTSA+APLAAGMIAL L+ P LTWRD+QH+
Sbjct: 346 YSSGVATDPQIVTTDLH----HGCTDQHTGTSASAPLAAGMIALALEANPFLTWRDMQHL 401
Query: 435 IVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLK 494
+V + + +W TN G SH +G+GLL+A LV+ A+ W +P V
Sbjct: 402 VVRASKPAHLQAEDWRTNGVGRQVSHHYGYGLLDAGLLVDTARTW--LPTQPQRKCAVRV 459
Query: 495 ENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMS 554
+++ P P + + NVS + +++LEHV +++++ RRG LE+ L P G S
Sbjct: 460 QSRPTPILP-LIYIRENVSACAGLHNSIRSLEHVQAQLTLSYSRRGDLEISLTSPMGTRS 518
Query: 555 LIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDESFQVGILRQWQLTLYG 614
+ A R +D G+N+W F + W E +G + L + + G F G L ++ L LYG
Sbjct: 519 TLVAIRPLDVSTEGYNNWVFMSTHFWDENPQGVWTLGLENKG-YYFNTGTLYRYTLLLYG 577
Query: 615 S-------------VWSAVDIRDRQRLLESAMSGKYLHDDFALP-CPP 648
+ SA RD + L ++ Y+ L CPP
Sbjct: 578 TAEDMTARPTGPQVTSSACVQRDTEGLCQACDGPAYILGQLCLAYCPP 625
>gi|20336244 proprotein convertase subtilisin/kexin type 2 [Homo
sapiens]
Length = 638
Score = 377 bits (967), Expect = e-104
Identities = 206/481 (42%), Positives = 290/481 (60%), Gaps = 13/481 (2%)
Query: 143 VHFNDPKYPQQWHLNNRR----SPGRDINVTGVWERNVTGRGVTVVVVDDGVEHTIQDIA 198
++ NDP + +QW+L N +PG D+NV WE TG+GVT+ ++DDG+++ D+A
Sbjct: 119 INMNDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLA 178
Query: 199 PNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGI 258
NY+ E SYD +SNDP P P + N HGTRCAGE++A NN+ C VGVAY S++AGI
Sbjct: 179 SNYNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGI 238
Query: 259 RVLDGP-LTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRQ 317
R+LD P +TD +EA + + Q+ DIYS SWGP D+GKTVDGP +L A+ GV GR
Sbjct: 239 RMLDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRG 298
Query: 318 GFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSG 377
G GSI+V ASG+GG + D+CN DGYA+S++T++I + +GR Y E C+S LA TFS
Sbjct: 299 GKGSIYVWASGDGGSY-DDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSN 357
Query: 378 GDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVF 437
G K DL CT H+GTSAAAP AAG+ AL L+ LTWRD+QH+ V
Sbjct: 358 GRKRNPEAGVATTDLY--GNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVL 415
Query: 438 TATRYE--DRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKE 495
T+ R + D +W N G +H G+G+L+A +V AK W +VP V +++
Sbjct: 416 TSKRNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQD 475
Query: 496 NKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSL 555
+ IP S L + + + + ++ LEHV +++ RRG L + + P G S+
Sbjct: 476 PEKIP-STGKLVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSI 534
Query: 556 IGAPRSMDSDPN-GFNDWTFSTVRCWGERARGTYRLVIRDVGDESFQVGILRQWQLTLYG 614
+ + R D D GF+ W F T WGE ARGT+ L + VG Q G+L++W L L+G
Sbjct: 535 LLSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAP-QKGVLKEWTLMLHG 593
Query: 615 S 615
+
Sbjct: 594 T 594
>gi|20336186 paired basic amino acid cleaving system 4 isoform c
preproprotein [Homo sapiens]
Length = 487
Score = 355 bits (912), Expect = 7e-98
Identities = 184/394 (46%), Positives = 242/394 (61%), Gaps = 19/394 (4%)
Query: 73 QADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQ-VEAVLAGHEAVRWHS 131
+AD +A A G +N G+IG L+ +Y F H + + + L V+W
Sbjct: 84 EADRVAAAHGYLNLGQIGNLEDYYHFY----HSKTFKRSTLSSRGPHTFLRMDPQVKWLQ 139
Query: 132 EQRLLRRAKRSV-------HFNDPKYPQQWHLNNRRSPGR---DINVTGVWERNVTGRGV 181
+Q + RR KR V +FNDP + W+L+ R ++NV W+R TG+ V
Sbjct: 140 QQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNV 199
Query: 182 TVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPN 241
V ++DDG+E D+APNY SYD+N ND DP P D N N HGTRCAGE+AA N
Sbjct: 200 VVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASAN 259
Query: 242 NSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPH 301
NS+C VG+AY ++I GIR+LDG +TD +EA + DIYS SWGPDDDGKTVDGP
Sbjct: 260 NSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPG 319
Query: 302 QLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMP 361
+L K A ++G+ GRQG GSIFV ASGNGG+ D C+ DGY NSIYT+++ + E G P
Sbjct: 320 RLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKP 379
Query: 362 FYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQ 421
+Y EECAS LA T+S G R IVTTD + CT+GHTGTS +AP+ AG+IAL L+
Sbjct: 380 WYLEECASTLATTYSSGAFYERKIVTTDLRQR----CTDGHTGTSVSAPMVAGIIALALE 435
Query: 422 VRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAG 455
LTWRDVQH++V T+ + ++W N AG
Sbjct: 436 ANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAG 469
>gi|31317307 proprotein convertase subtilisin/kexin type 9
preproprotein [Homo sapiens]
Length = 692
Score = 36.2 bits (82), Expect = 0.12
Identities = 58/232 (25%), Positives = 94/232 (40%), Gaps = 39/232 (16%)
Query: 219 HPDVENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLD----GPLTDSMEAVAF 274
H + HGT AG ++ GVA G+ + +RVL+ G ++ ++ + F
Sbjct: 217 HRQASKCDSHGTHLAGVVSGRD------AGVAKGASMRSLRVLNCQGKGTVSGTLIGLEF 270
Query: 275 NKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHN 334
+ Q+ GP V P G + + + G + V A+GN +
Sbjct: 271 IRKSQLVQPV----GP----LVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNF--RD 320
Query: 335 DNCNYDGYANSIYTVTIGAVDEE------GRMPFYAEECASMLAVTFSGGDKMLRSIVTT 388
D C Y A++ +T+GA + + G + C + A G D I+
Sbjct: 321 DACLYSP-ASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFA---PGED-----IIGA 371
Query: 389 DWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDV-QHIIVFTA 439
D C +GTS AA AG+ A+ML P LT ++ Q +I F+A
Sbjct: 372 SSDCST---CFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSA 420
>gi|65288071 tensin 3 [Homo sapiens]
Length = 1445
Score = 34.7 bits (78), Expect = 0.35
Identities = 17/54 (31%), Positives = 27/54 (50%), Gaps = 5/54 (9%)
Query: 265 LTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRQG 318
LTD+ + F +HY +N + C+ P D DGP ++ G +A +QG
Sbjct: 1360 LTDNQRKLFFRRHYPVNSVIFCALDPQDRKWIKDGP-----SSKVFGFVARKQG 1408
>gi|4506775 membrane-bound transcription factor site-1 protease
preproprotein [Homo sapiens]
Length = 1052
Score = 34.3 bits (77), Expect = 0.46
Identities = 91/397 (22%), Positives = 146/397 (36%), Gaps = 83/397 (20%)
Query: 128 RWHSEQRLLRRAKRSVHFNDPKYPQQWHLNNRRSPGR-----------DINVTGVWERNV 176
+W S R LRRA S+ WH R S R + +W+
Sbjct: 155 KWQSS-RPLRRASLSLGSGF------WHATGRHSSRRLLRAIPRQVAQTLQADVLWQMGY 207
Query: 177 TGRGVTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEI 236
TG V V V D G + + P++ +N+ +++G HGT AG I
Sbjct: 208 TGANVRVAVFDTG----LSEKHPHFKNVKERTNWTNERT------LDDGLGHGTFVAGVI 257
Query: 237 AAVPNNSFCAVGVAYGSRIAGIRVLDGPLTD--SMEAVAFNKHYQIN---DIYSCSWGPD 291
A++ G A + + RV S AFN Y I D+ + S G
Sbjct: 258 ASMRE----CQGFAPDAELHIFRVFTNNQVSYTSWFLDAFN--YAILKKIDVLNLSIGGP 311
Query: 292 D--DGKTVDGPHQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTV 349
D D VD +L + I V A GN G N A+ + +
Sbjct: 312 DFMDHPFVDKVWELTANNV-------------IMVSAIGNDGPLYGTLNNP--ADQMDVI 356
Query: 350 TIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGH---TGTS 406
+G +D E + ++ M GG ++ + T +G+G G +GTS
Sbjct: 357 GVGGIDFEDNIARFSSR--GMTTWELPGGYGRMKPDIVTYGAGVRGSGVKGGCRALSGTS 414
Query: 407 AAAPLAAGMIALM---LQVRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHG 463
A+P+ AG + L+ +Q R + ++ ++ +A R + F H
Sbjct: 415 VASPVVAGAVTLLVSTVQKRELVNPASMKQALIASARR--------LPGVNMFEQGHGK- 465
Query: 464 FGLLNAWRLVNAAKIWTSV----------PYLASYVS 490
LL A++++N+ K S+ PY+ Y S
Sbjct: 466 LDLLRAYQILNSYKPQASLSPSYIDLTECPYMWPYCS 502
>gi|20070331 oxysterol binding protein-like 9 isoform e [Homo
sapiens]
Length = 736
Score = 32.3 bits (72), Expect = 1.7
Identities = 35/136 (25%), Positives = 53/136 (38%), Gaps = 20/136 (14%)
Query: 264 PLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAAL------QHGVIAGRQ 317
P + A FNK Q N + W G H +G+ + +H ++
Sbjct: 503 PPISAFYAECFNKKIQFN---AHIWTKSKFLGMSIGVHNIGQGCVSCLDYDEHYILTFPN 559
Query: 318 GFG-SIFVVASGN-GGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTF 375
G+G SI V GG+ N NC+ GY+ +I T PFY + + A F
Sbjct: 560 GYGRSILTVPWVELGGECNINCSKTGYSANIIFHT---------KPFYGGKKHRITAEIF 610
Query: 376 SGGDKMLRSIVTTDWD 391
S DK + +W+
Sbjct: 611 SPNDKKSFCSIEGEWN 626
>gi|22547176 oxysterol binding protein-like 9 isoform f [Homo
sapiens]
Length = 746
Score = 32.3 bits (72), Expect = 1.7
Identities = 35/136 (25%), Positives = 53/136 (38%), Gaps = 20/136 (14%)
Query: 264 PLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAAL------QHGVIAGRQ 317
P + A FNK Q N + W G H +G+ + +H ++
Sbjct: 513 PPISAFYAECFNKKIQFN---AHIWTKSKFLGMSIGVHNIGQGCVSCLDYDEHYILTFPN 569
Query: 318 GFG-SIFVVASGN-GGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTF 375
G+G SI V GG+ N NC+ GY+ +I T PFY + + A F
Sbjct: 570 GYGRSILTVPWVELGGECNINCSKTGYSANIIFHT---------KPFYGGKKHRITAEIF 620
Query: 376 SGGDKMLRSIVTTDWD 391
S DK + +W+
Sbjct: 621 SPNDKKSFCSIEGEWN 636
>gi|22547173 oxysterol binding protein-like 9 isoform d [Homo
sapiens]
Length = 723
Score = 32.3 bits (72), Expect = 1.7
Identities = 35/136 (25%), Positives = 53/136 (38%), Gaps = 20/136 (14%)
Query: 264 PLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAAL------QHGVIAGRQ 317
P + A FNK Q N + W G H +G+ + +H ++
Sbjct: 490 PPISAFYAECFNKKIQFN---AHIWTKSKFLGMSIGVHNIGQGCVSCLDYDEHYILTFPN 546
Query: 318 GFG-SIFVVASGN-GGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTF 375
G+G SI V GG+ N NC+ GY+ +I T PFY + + A F
Sbjct: 547 GYGRSILTVPWVELGGECNINCSKTGYSANIIFHT---------KPFYGGKKHRITAEIF 597
Query: 376 SGGDKMLRSIVTTDWD 391
S DK + +W+
Sbjct: 598 SPNDKKSFCSIEGEWN 613
>gi|22547171 oxysterol binding protein-like 9 isoform c [Homo
sapiens]
Length = 626
Score = 32.3 bits (72), Expect = 1.7
Identities = 35/136 (25%), Positives = 53/136 (38%), Gaps = 20/136 (14%)
Query: 264 PLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAAL------QHGVIAGRQ 317
P + A FNK Q N + W G H +G+ + +H ++
Sbjct: 393 PPISAFYAECFNKKIQFN---AHIWTKSKFLGMSIGVHNIGQGCVSCLDYDEHYILTFPN 449
Query: 318 GFG-SIFVVASGN-GGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTF 375
G+G SI V GG+ N NC+ GY+ +I T PFY + + A F
Sbjct: 450 GYGRSILTVPWVELGGECNINCSKTGYSANIIFHT---------KPFYGGKKHRITAEIF 500
Query: 376 SGGDKMLRSIVTTDWD 391
S DK + +W+
Sbjct: 501 SPNDKKSFCSIEGEWN 516
>gi|22547169 oxysterol binding protein-like 9 isoform b [Homo
sapiens]
Length = 571
Score = 32.3 bits (72), Expect = 1.7
Identities = 35/136 (25%), Positives = 53/136 (38%), Gaps = 20/136 (14%)
Query: 264 PLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAAL------QHGVIAGRQ 317
P + A FNK Q N + W G H +G+ + +H ++
Sbjct: 338 PPISAFYAECFNKKIQFN---AHIWTKSKFLGMSIGVHNIGQGCVSCLDYDEHYILTFPN 394
Query: 318 GFG-SIFVVASGN-GGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTF 375
G+G SI V GG+ N NC+ GY+ +I T PFY + + A F
Sbjct: 395 GYGRSILTVPWVELGGECNINCSKTGYSANIIFHT---------KPFYGGKKHRITAEIF 445
Query: 376 SGGDKMLRSIVTTDWD 391
S DK + +W+
Sbjct: 446 SPNDKKSFCSIEGEWN 461
>gi|22547167 oxysterol binding protein-like 9 isoform a [Homo
sapiens]
Length = 558
Score = 32.3 bits (72), Expect = 1.7
Identities = 35/136 (25%), Positives = 53/136 (38%), Gaps = 20/136 (14%)
Query: 264 PLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAAL------QHGVIAGRQ 317
P + A FNK Q N + W G H +G+ + +H ++
Sbjct: 325 PPISAFYAECFNKKIQFN---AHIWTKSKFLGMSIGVHNIGQGCVSCLDYDEHYILTFPN 381
Query: 318 GFG-SIFVVASGN-GGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTF 375
G+G SI V GG+ N NC+ GY+ +I T PFY + + A F
Sbjct: 382 GYGRSILTVPWVELGGECNINCSKTGYSANIIFHT---------KPFYGGKKHRITAEIF 432
Query: 376 SGGDKMLRSIVTTDWD 391
S DK + +W+
Sbjct: 433 SPNDKKSFCSIEGEWN 448
>gi|22547165 oxysterol binding protein-like 9 isoform a [Homo
sapiens]
Length = 558
Score = 32.3 bits (72), Expect = 1.7
Identities = 35/136 (25%), Positives = 53/136 (38%), Gaps = 20/136 (14%)
Query: 264 PLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAAL------QHGVIAGRQ 317
P + A FNK Q N + W G H +G+ + +H ++
Sbjct: 325 PPISAFYAECFNKKIQFN---AHIWTKSKFLGMSIGVHNIGQGCVSCLDYDEHYILTFPN 381
Query: 318 GFG-SIFVVASGN-GGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTF 375
G+G SI V GG+ N NC+ GY+ +I T PFY + + A F
Sbjct: 382 GYGRSILTVPWVELGGECNINCSKTGYSANIIFHT---------KPFYGGKKHRITAEIF 432
Query: 376 SGGDKMLRSIVTTDWD 391
S DK + +W+
Sbjct: 433 SPNDKKSFCSIEGEWN 448
>gi|33286442 BCL6 co-repressor-like 1 [Homo sapiens]
Length = 1711
Score = 31.2 bits (69), Expect = 3.9
Identities = 23/77 (29%), Positives = 31/77 (40%), Gaps = 8/77 (10%)
Query: 701 SGPCHWPHRSRKAKEEGTELESVPLCSSKDPDEVETESRGPPTTSDLLAPDLLEQGDWSL 760
S P H P + E+ TE SV K P ++E E PP S++ D S
Sbjct: 575 SAPPH-PAKMPSGTEQQTEGTSVTFSPLKSPPQLEREMASPPECSEMPL-------DLSS 626
Query: 761 SQNKSALDCPHQHLDVP 777
N+ L P+Q P
Sbjct: 627 KSNRQKLPLPNQRKTPP 643
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 30.8 bits (68), Expect = 5.1
Identities = 27/85 (31%), Positives = 40/85 (47%), Gaps = 4/85 (4%)
Query: 55 AVHLESLEGDGEEETLEQQADALAQA---AGLVNAGRIGELQGHYLFVQPAGHRPALEVE 111
A+ E + G+EE ++++ADAL A A + R GELQ H + A+E
Sbjct: 1821 ALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGR 1880
Query: 112 AIRQQVEAVLAGHEAVRWHSEQRLL 136
+ Q +E VL A E+ LL
Sbjct: 1881 RV-QALEEVLGDLRAESREQEKALL 1904
>gi|214830451 sequestosome 1 isoform 2 [Homo sapiens]
Length = 356
Score = 30.8 bits (68), Expect = 5.1
Identities = 20/71 (28%), Positives = 32/71 (45%), Gaps = 2/71 (2%)
Query: 699 CRSGPCHWPHRSRKAKEEGT-ELESVPLCSSKDPDEVETESRGPPTTSD-LLAPDLLEQG 756
C G W H S K + T EL+S+ + S+ P ++ GP + L P L +
Sbjct: 247 CSGGDDDWTHLSSKEVDPSTGELQSLQMPESEGPSSLDPSQEGPTGLKEAALYPHLPPEA 306
Query: 757 DWSLSQNKSAL 767
D L ++ S +
Sbjct: 307 DPRLIESLSQM 317
>gi|214830438 sequestosome 1 isoform 2 [Homo sapiens]
Length = 356
Score = 30.8 bits (68), Expect = 5.1
Identities = 20/71 (28%), Positives = 32/71 (45%), Gaps = 2/71 (2%)
Query: 699 CRSGPCHWPHRSRKAKEEGT-ELESVPLCSSKDPDEVETESRGPPTTSD-LLAPDLLEQG 756
C G W H S K + T EL+S+ + S+ P ++ GP + L P L +
Sbjct: 247 CSGGDDDWTHLSSKEVDPSTGELQSLQMPESEGPSSLDPSQEGPTGLKEAALYPHLPPEA 306
Query: 757 DWSLSQNKSAL 767
D L ++ S +
Sbjct: 307 DPRLIESLSQM 317
>gi|4505571 sequestosome 1 isoform 1 [Homo sapiens]
Length = 440
Score = 30.8 bits (68), Expect = 5.1
Identities = 20/71 (28%), Positives = 32/71 (45%), Gaps = 2/71 (2%)
Query: 699 CRSGPCHWPHRSRKAKEEGT-ELESVPLCSSKDPDEVETESRGPPTTSD-LLAPDLLEQG 756
C G W H S K + T EL+S+ + S+ P ++ GP + L P L +
Sbjct: 331 CSGGDDDWTHLSSKEVDPSTGELQSLQMPESEGPSSLDPSQEGPTGLKEAALYPHLPPEA 390
Query: 757 DWSLSQNKSAL 767
D L ++ S +
Sbjct: 391 DPRLIESLSQM 401
>gi|94536852 transmembrane cochlear-expressed protein 2 [Homo
sapiens]
Length = 906
Score = 30.8 bits (68), Expect = 5.1
Identities = 28/96 (29%), Positives = 41/96 (42%), Gaps = 9/96 (9%)
Query: 668 LVLVGCFTVFWTVYYMLEVY--LSQRNVASN---QVCRSGPCHWPHRSRKAKEEGTELES 722
L++ +F +YY+ V LS+ N QV R H+S K K + E
Sbjct: 760 LIIPAILLMFLAIYYLNSVSKSLSRANAQLRKKIQVLRE--VEKSHKSVKGKATARDSED 817
Query: 723 VPLCSSKDPDEVE--TESRGPPTTSDLLAPDLLEQG 756
P SSK+ +++ E PP+ S A D QG
Sbjct: 818 TPKSSSKNATQLQLTKEETTPPSASQSQAMDKKAQG 853
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.427
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,170,887
Number of Sequences: 37866
Number of extensions: 1682414
Number of successful extensions: 4256
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 16
Number of HSP's successfully gapped in prelim test: 19
Number of HSP's that attempted gapping in prelim test: 4174
Number of HSP's gapped (non-prelim): 39
length of query: 785
length of database: 18,247,518
effective HSP length: 110
effective length of query: 675
effective length of database: 14,082,258
effective search space: 9505524150
effective search space used: 9505524150
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.