Guide to the Human Genome
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Search of human proteins with 20336248

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|20336248 proprotein convertase subtilisin/kexin type 7
preproprotein [Homo sapiens]
         (785 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|20336248 proprotein convertase subtilisin/kexin type 7 prepro...  1635   0.0  
gi|20336182 paired basic amino acid cleaving system 4 isoform g ...   462   e-130
gi|4505577 paired basic amino acid cleaving system 4 isoform a p...   462   e-130
gi|20336184 paired basic amino acid cleaving system 4 isoform h ...   461   e-129
gi|20336180 paired basic amino acid cleaving system 4 isoform b ...   461   e-129
gi|20336246 proprotein convertase subtilisin/kexin type 5 prepro...   457   e-128
gi|20336188 paired basic amino acid cleaving system 4 isoform e ...   446   e-125
gi|27894285 paired basic amino acid cleaving system 4 isoform f ...   446   e-125
gi|20336190 paired basic amino acid cleaving system 4 isoform d ...   446   e-125
gi|4505579 furin preproprotein [Homo sapiens]                         427   e-119
gi|20336242 proprotein convertase subtilisin/kexin type 1 prepro...   425   e-119
gi|76443679 proprotein convertase subtilisin/kexin type 4 [Homo ...   422   e-118
gi|20336244 proprotein convertase subtilisin/kexin type 2 [Homo ...   377   e-104
gi|20336186 paired basic amino acid cleaving system 4 isoform c ...   355   7e-98
gi|31317307 proprotein convertase subtilisin/kexin type 9 prepro...    36   0.12 
gi|65288071 tensin 3 [Homo sapiens]                                    35   0.35 
gi|4506775 membrane-bound transcription factor site-1 protease p...    34   0.46 
gi|20070331 oxysterol binding protein-like 9 isoform e [Homo sap...    32   1.7  
gi|22547176 oxysterol binding protein-like 9 isoform f [Homo sap...    32   1.7  
gi|22547173 oxysterol binding protein-like 9 isoform d [Homo sap...    32   1.7  
gi|22547171 oxysterol binding protein-like 9 isoform c [Homo sap...    32   1.7  
gi|22547169 oxysterol binding protein-like 9 isoform b [Homo sap...    32   1.7  
gi|22547167 oxysterol binding protein-like 9 isoform a [Homo sap...    32   1.7  
gi|22547165 oxysterol binding protein-like 9 isoform a [Homo sap...    32   1.7  
gi|33286442 BCL6 co-repressor-like 1 [Homo sapiens]                    31   3.9  
gi|21735548 centrosomal protein 2 [Homo sapiens]                       31   5.1  
gi|214830451 sequestosome 1 isoform 2 [Homo sapiens]                   31   5.1  
gi|214830438 sequestosome 1 isoform 2 [Homo sapiens]                   31   5.1  
gi|4505571 sequestosome 1 isoform 1 [Homo sapiens]                     31   5.1  
gi|94536852 transmembrane cochlear-expressed protein 2 [Homo sap...    31   5.1  

>gi|20336248 proprotein convertase subtilisin/kexin type 7
           preproprotein [Homo sapiens]
          Length = 785

 Score = 1635 bits (4233), Expect = 0.0
 Identities = 785/785 (100%), Positives = 785/785 (100%)

Query: 1   MPKGRQKVPHLDAPLGLPTCLWLELAGLFLLVPWVMGLAGTGGPDGQGTGGPSWAVHLES 60
           MPKGRQKVPHLDAPLGLPTCLWLELAGLFLLVPWVMGLAGTGGPDGQGTGGPSWAVHLES
Sbjct: 1   MPKGRQKVPHLDAPLGLPTCLWLELAGLFLLVPWVMGLAGTGGPDGQGTGGPSWAVHLES 60

Query: 61  LEGDGEEETLEQQADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQVEAV 120
           LEGDGEEETLEQQADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQVEAV
Sbjct: 61  LEGDGEEETLEQQADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQVEAV 120

Query: 121 LAGHEAVRWHSEQRLLRRAKRSVHFNDPKYPQQWHLNNRRSPGRDINVTGVWERNVTGRG 180
           LAGHEAVRWHSEQRLLRRAKRSVHFNDPKYPQQWHLNNRRSPGRDINVTGVWERNVTGRG
Sbjct: 121 LAGHEAVRWHSEQRLLRRAKRSVHFNDPKYPQQWHLNNRRSPGRDINVTGVWERNVTGRG 180

Query: 181 VTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVP 240
           VTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVP
Sbjct: 181 VTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVP 240

Query: 241 NNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGP 300
           NNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGP
Sbjct: 241 NNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGP 300

Query: 301 HQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRM 360
           HQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRM
Sbjct: 301 HQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRM 360

Query: 361 PFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALML 420
           PFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALML
Sbjct: 361 PFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALML 420

Query: 421 QVRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWT 480
           QVRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWT
Sbjct: 421 QVRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWT 480

Query: 481 SVPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRG 540
           SVPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRG
Sbjct: 481 SVPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRG 540

Query: 541 SLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDESF 600
           SLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDESF
Sbjct: 541 SLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDESF 600

Query: 601 QVGILRQWQLTLYGSVWSAVDIRDRQRLLESAMSGKYLHDDFALPCPPGLKIPEEDGYTI 660
           QVGILRQWQLTLYGSVWSAVDIRDRQRLLESAMSGKYLHDDFALPCPPGLKIPEEDGYTI
Sbjct: 601 QVGILRQWQLTLYGSVWSAVDIRDRQRLLESAMSGKYLHDDFALPCPPGLKIPEEDGYTI 660

Query: 661 TPNTLKTLVLVGCFTVFWTVYYMLEVYLSQRNVASNQVCRSGPCHWPHRSRKAKEEGTEL 720
           TPNTLKTLVLVGCFTVFWTVYYMLEVYLSQRNVASNQVCRSGPCHWPHRSRKAKEEGTEL
Sbjct: 661 TPNTLKTLVLVGCFTVFWTVYYMLEVYLSQRNVASNQVCRSGPCHWPHRSRKAKEEGTEL 720

Query: 721 ESVPLCSSKDPDEVETESRGPPTTSDLLAPDLLEQGDWSLSQNKSALDCPHQHLDVPHGK 780
           ESVPLCSSKDPDEVETESRGPPTTSDLLAPDLLEQGDWSLSQNKSALDCPHQHLDVPHGK
Sbjct: 721 ESVPLCSSKDPDEVETESRGPPTTSDLLAPDLLEQGDWSLSQNKSALDCPHQHLDVPHGK 780

Query: 781 EEQIC 785
           EEQIC
Sbjct: 781 EEQIC 785


>gi|20336182 paired basic amino acid cleaving system 4 isoform g
           preproprotein [Homo sapiens]
          Length = 975

 Score =  462 bits (1188), Expect = e-130
 Identities = 263/622 (42%), Positives = 354/622 (56%), Gaps = 31/622 (4%)

Query: 73  QADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQ-VEAVLAGHEAVRWHS 131
           +AD +A A G +N G+IG L+ +Y F     H    +   +  +     L     V+W  
Sbjct: 84  EADRVAAAHGYLNLGQIGNLEDYYHFY----HSKTFKRSTLSSRGPHTFLRMDPQVKWLQ 139

Query: 132 EQRLLRRAKRSV-------HFNDPKYPQQWHLNNRRSPGR---DINVTGVWERNVTGRGV 181
           +Q + RR KR V       +FNDP +   W+L+      R   ++NV   W+R  TG+ V
Sbjct: 140 QQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNV 199

Query: 182 TVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPN 241
            V ++DDG+E    D+APNY    SYD+N ND DP P  D  N N HGTRCAGE+AA  N
Sbjct: 200 VVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASAN 259

Query: 242 NSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPH 301
           NS+C VG+AY ++I GIR+LDG +TD +EA +        DIYS SWGPDDDGKTVDGP 
Sbjct: 260 NSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPG 319

Query: 302 QLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMP 361
           +L K A ++G+  GRQG GSIFV ASGNGG+  D C+ DGY NSIYT+++ +  E G  P
Sbjct: 320 RLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKP 379

Query: 362 FYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQ 421
           +Y EECAS LA T+S G    R IVTTD   +    CT+GHTGTS +AP+ AG+IAL L+
Sbjct: 380 WYLEECASTLATTYSSGAFYERKIVTTDLRQR----CTDGHTGTSVSAPMVAGIIALALE 435

Query: 422 VRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTS 481
               LTWRDVQH++V T+     + ++W  N AG   SH +GFGL++A  LV  AK WT+
Sbjct: 436 ANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTA 495

Query: 482 VPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGS 541
           VP     V+   K  ++IP            +  +     +  LEHV V  SI+HPRRG 
Sbjct: 496 VPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGD 555

Query: 542 LELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDE--- 598
           L++ L  PSG  S + A R +D    GF +W F TV CWGE+A G + L I+D+  +   
Sbjct: 556 LQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRN 615

Query: 599 SFQVGILRQWQLTLYGSVWSAVDI----RDRQRLLESAMSGKYLHDDFALPCPPGLKIPE 654
             + G L++W L LYG+           + R R+LE  +S   L    A   P  +++PE
Sbjct: 616 PEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLE--LSAPELEPPKAALSPSQVEVPE 673

Query: 655 -EDGYTI--TPNTLKTLVLVGC 673
            E+ YT   TP +   L    C
Sbjct: 674 DEEDYTAQSTPGSANILQTSVC 695


>gi|4505577 paired basic amino acid cleaving system 4 isoform a
           preproprotein [Homo sapiens]
          Length = 969

 Score =  462 bits (1188), Expect = e-130
 Identities = 263/622 (42%), Positives = 354/622 (56%), Gaps = 31/622 (4%)

Query: 73  QADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQ-VEAVLAGHEAVRWHS 131
           +AD +A A G +N G+IG L+ +Y F     H    +   +  +     L     V+W  
Sbjct: 84  EADRVAAAHGYLNLGQIGNLEDYYHFY----HSKTFKRSTLSSRGPHTFLRMDPQVKWLQ 139

Query: 132 EQRLLRRAKRSV-------HFNDPKYPQQWHLNNRRSPGR---DINVTGVWERNVTGRGV 181
           +Q + RR KR V       +FNDP +   W+L+      R   ++NV   W+R  TG+ V
Sbjct: 140 QQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNV 199

Query: 182 TVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPN 241
            V ++DDG+E    D+APNY    SYD+N ND DP P  D  N N HGTRCAGE+AA  N
Sbjct: 200 VVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASAN 259

Query: 242 NSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPH 301
           NS+C VG+AY ++I GIR+LDG +TD +EA +        DIYS SWGPDDDGKTVDGP 
Sbjct: 260 NSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPG 319

Query: 302 QLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMP 361
           +L K A ++G+  GRQG GSIFV ASGNGG+  D C+ DGY NSIYT+++ +  E G  P
Sbjct: 320 RLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKP 379

Query: 362 FYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQ 421
           +Y EECAS LA T+S G    R IVTTD   +    CT+GHTGTS +AP+ AG+IAL L+
Sbjct: 380 WYLEECASTLATTYSSGAFYERKIVTTDLRQR----CTDGHTGTSVSAPMVAGIIALALE 435

Query: 422 VRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTS 481
               LTWRDVQH++V T+     + ++W  N AG   SH +GFGL++A  LV  AK WT+
Sbjct: 436 ANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTA 495

Query: 482 VPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGS 541
           VP     V+   K  ++IP            +  +     +  LEHV V  SI+HPRRG 
Sbjct: 496 VPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGD 555

Query: 542 LELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDE--- 598
           L++ L  PSG  S + A R +D    GF +W F TV CWGE+A G + L I+D+  +   
Sbjct: 556 LQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRN 615

Query: 599 SFQVGILRQWQLTLYGSVWSAVDI----RDRQRLLESAMSGKYLHDDFALPCPPGLKIPE 654
             + G L++W L LYG+           + R R+LE  +S   L    A   P  +++PE
Sbjct: 616 PEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLE--LSAPELEPPKAALSPSQVEVPE 673

Query: 655 -EDGYTI--TPNTLKTLVLVGC 673
            E+ YT   TP +   L    C
Sbjct: 674 DEEDYTAQSTPGSANILQTSVC 695


>gi|20336184 paired basic amino acid cleaving system 4 isoform h
           preproprotein [Homo sapiens]
          Length = 962

 Score =  461 bits (1186), Expect = e-129
 Identities = 259/606 (42%), Positives = 349/606 (57%), Gaps = 29/606 (4%)

Query: 73  QADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQ-VEAVLAGHEAVRWHS 131
           +AD +A A G +N G+IG L+ +Y F     H    +   +  +     L     V+W  
Sbjct: 84  EADRVAAAHGYLNLGQIGNLEDYYHFY----HSKTFKRSTLSSRGPHTFLRMDPQVKWLQ 139

Query: 132 EQRLLRRAKRSV-------HFNDPKYPQQWHLNNRRSPGR---DINVTGVWERNVTGRGV 181
           +Q + RR KR V       +FNDP +   W+L+      R   ++NV   W+R  TG+ V
Sbjct: 140 QQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNV 199

Query: 182 TVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPN 241
            V ++DDG+E    D+APNY    SYD+N ND DP P  D  N N HGTRCAGE+AA  N
Sbjct: 200 VVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASAN 259

Query: 242 NSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPH 301
           NS+C VG+AY ++I GIR+LDG +TD +EA +        DIYS SWGPDDDGKTVDGP 
Sbjct: 260 NSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPG 319

Query: 302 QLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMP 361
           +L K A ++G+  GRQG GSIFV ASGNGG+  D C+ DGY NSIYT+++ +  E G  P
Sbjct: 320 RLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKP 379

Query: 362 FYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQ 421
           +Y EECAS LA T+S G    R IVTTD   +    CT+GHTGTS +AP+ AG+IAL L+
Sbjct: 380 WYLEECASTLATTYSSGAFYERKIVTTDLRQR----CTDGHTGTSVSAPMVAGIIALALE 435

Query: 422 VRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTS 481
               LTWRDVQH++V T+     + ++W  N AG   SH +GFGL++A  LV  AK WT+
Sbjct: 436 ANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTA 495

Query: 482 VPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGS 541
           VP     V+   K  ++IP            +  +     +  LEHV V  SI+HPRRG 
Sbjct: 496 VPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGD 555

Query: 542 LELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDE--- 598
           L++ L  PSG  S + A R +D    GF +W F TV CWGE+A G + L I+D+  +   
Sbjct: 556 LQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRN 615

Query: 599 SFQVGILRQWQLTLYGSVWSAVDI----RDRQRLLESAMSGKYLHDDFALPCPPGLKIPE 654
             + G L++W L LYG+           + R R+LE  +S   L    A   P  +++PE
Sbjct: 616 PEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLE--LSAPELEPPKAALSPSQVEVPE 673

Query: 655 -EDGYT 659
            E+ YT
Sbjct: 674 DEEDYT 679


>gi|20336180 paired basic amino acid cleaving system 4 isoform b
           preproprotein [Homo sapiens]
          Length = 956

 Score =  461 bits (1186), Expect = e-129
 Identities = 259/606 (42%), Positives = 349/606 (57%), Gaps = 29/606 (4%)

Query: 73  QADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQ-VEAVLAGHEAVRWHS 131
           +AD +A A G +N G+IG L+ +Y F     H    +   +  +     L     V+W  
Sbjct: 84  EADRVAAAHGYLNLGQIGNLEDYYHFY----HSKTFKRSTLSSRGPHTFLRMDPQVKWLQ 139

Query: 132 EQRLLRRAKRSV-------HFNDPKYPQQWHLNNRRSPGR---DINVTGVWERNVTGRGV 181
           +Q + RR KR V       +FNDP +   W+L+      R   ++NV   W+R  TG+ V
Sbjct: 140 QQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNV 199

Query: 182 TVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPN 241
            V ++DDG+E    D+APNY    SYD+N ND DP P  D  N N HGTRCAGE+AA  N
Sbjct: 200 VVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASAN 259

Query: 242 NSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPH 301
           NS+C VG+AY ++I GIR+LDG +TD +EA +        DIYS SWGPDDDGKTVDGP 
Sbjct: 260 NSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPG 319

Query: 302 QLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMP 361
           +L K A ++G+  GRQG GSIFV ASGNGG+  D C+ DGY NSIYT+++ +  E G  P
Sbjct: 320 RLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKP 379

Query: 362 FYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQ 421
           +Y EECAS LA T+S G    R IVTTD   +    CT+GHTGTS +AP+ AG+IAL L+
Sbjct: 380 WYLEECASTLATTYSSGAFYERKIVTTDLRQR----CTDGHTGTSVSAPMVAGIIALALE 435

Query: 422 VRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTS 481
               LTWRDVQH++V T+     + ++W  N AG   SH +GFGL++A  LV  AK WT+
Sbjct: 436 ANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTA 495

Query: 482 VPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGS 541
           VP     V+   K  ++IP            +  +     +  LEHV V  SI+HPRRG 
Sbjct: 496 VPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGD 555

Query: 542 LELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDE--- 598
           L++ L  PSG  S + A R +D    GF +W F TV CWGE+A G + L I+D+  +   
Sbjct: 556 LQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRN 615

Query: 599 SFQVGILRQWQLTLYGSVWSAVDI----RDRQRLLESAMSGKYLHDDFALPCPPGLKIPE 654
             + G L++W L LYG+           + R R+LE  +S   L    A   P  +++PE
Sbjct: 616 PEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLE--LSAPELEPPKAALSPSQVEVPE 673

Query: 655 -EDGYT 659
            E+ YT
Sbjct: 674 DEEDYT 679


>gi|20336246 proprotein convertase subtilisin/kexin type 5
           preproprotein [Homo sapiens]
          Length = 913

 Score =  457 bits (1177), Expect = e-128
 Identities = 248/598 (41%), Positives = 349/598 (58%), Gaps = 30/598 (5%)

Query: 73  QADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQ-VEAVLAGHEAVRWHS 131
           +A+ +A   G +N G+IG L+ +Y F     H   ++   I  +   + ++    V W  
Sbjct: 49  EANRIASKYGFINIGQIGALKDYYHFY----HSRTIKRSVISSRGTHSFISMEPKVEWIQ 104

Query: 132 EQRLLRRAKR--------SVHFNDPKYPQQWHLN---NRRSPGRDINVTGVWERNVTGRG 180
           +Q + +R KR        S +FNDPK+P  W+++   N      D+N+ G W+R  TG+ 
Sbjct: 105 QQVVKKRTKRDYDFSRAQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKN 164

Query: 181 VTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVP 240
           + V ++DDG+E T  D+  NY    S D+N ND DPMP  D  N N HGTRCAGE+AA  
Sbjct: 165 IVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAA 224

Query: 241 NNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGP 300
           NNS C VG+A+ ++I G+R+LDG +TD +EA + + + Q   IYS SWGPDDDGKTVDGP
Sbjct: 225 NNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGP 284

Query: 301 HQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRM 360
             L + A ++GV  GR+G GS+FV ASGNGG+  D+C+ DGY NSIYT++I +  E G+ 
Sbjct: 285 APLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKK 344

Query: 361 PFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALML 420
           P+Y EEC+S LA T+S G+   + I+TTD   +    CT+ HTGTSA+AP+AAG+IAL L
Sbjct: 345 PWYLEECSSTLATTYSSGESYDKKIITTDLRQR----CTDNHTGTSASAPMAAGIIALAL 400

Query: 421 QVRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWT 480
           +  P LTWRDVQH+IV T+        +W TN AGF  SH +GFGL++A  +V  A+ WT
Sbjct: 401 EANPFLTWRDVQHVIVRTSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWT 460

Query: 481 SVPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRG 540
           +VP     V    ++ K I  +     +       D     +  LEHV V ++ITHPRRG
Sbjct: 461 TVPRQHVCVESTDRQIKTIRPNSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRG 520

Query: 541 SLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDE-- 598
            L + L  PSG  S + A R  D    GF +W F T+ CWGERA G + L + D   +  
Sbjct: 521 DLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLR 580

Query: 599 SFQV-GILRQWQLTLYGSVWSAVDIRDR----QRLLESAM---SGKYLHDDFALPCPP 648
           +F+  G L++W L LYG+        +     +R   S +   +  Y  +D+A PC P
Sbjct: 581 NFKTPGKLKEWSLVLYGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDP 638


>gi|20336188 paired basic amino acid cleaving system 4 isoform e
           preproprotein [Homo sapiens]
          Length = 623

 Score =  446 bits (1148), Expect = e-125
 Identities = 239/534 (44%), Positives = 317/534 (59%), Gaps = 19/534 (3%)

Query: 73  QADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQ-VEAVLAGHEAVRWHS 131
           +AD +A A G +N G+IG L+ +Y F     H    +   +  +     L     V+W  
Sbjct: 84  EADRVAAAHGYLNLGQIGNLEDYYHFY----HSKTFKRSTLSSRGPHTFLRMDPQVKWLQ 139

Query: 132 EQRLLRRAKRSV-------HFNDPKYPQQWHLNNRRSPGR---DINVTGVWERNVTGRGV 181
           +Q + RR KR V       +FNDP +   W+L+      R   ++NV   W+R  TG+ V
Sbjct: 140 QQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNV 199

Query: 182 TVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPN 241
            V ++DDG+E    D+APNY    SYD+N ND DP P  D  N N HGTRCAGE+AA  N
Sbjct: 200 VVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASAN 259

Query: 242 NSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPH 301
           NS+C VG+AY ++I GIR+LDG +TD +EA +        DIYS SWGPDDDGKTVDGP 
Sbjct: 260 NSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPG 319

Query: 302 QLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMP 361
           +L K A ++G+  GRQG GSIFV ASGNGG+  D C+ DGY NSIYT+++ +  E G  P
Sbjct: 320 RLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKP 379

Query: 362 FYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQ 421
           +Y EECAS LA T+S G    R IVTTD   +    CT+GHTGTS +AP+ AG+IAL L+
Sbjct: 380 WYLEECASTLATTYSSGAFYERKIVTTDLRQR----CTDGHTGTSVSAPMVAGIIALALE 435

Query: 422 VRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTS 481
               LTWRDVQH++V T+     + ++W  N AG   SH +GFGL++A  LV  AK WT+
Sbjct: 436 ANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTA 495

Query: 482 VPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGS 541
           VP     V+   K  ++IP            +  +     +  LEHV V  SI+HPRRG 
Sbjct: 496 VPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGD 555

Query: 542 LELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDV 595
           L++ L  PSG  S + A R +D    GF +W F TV CWGE+A G + L I+D+
Sbjct: 556 LQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDL 609


>gi|27894285 paired basic amino acid cleaving system 4 isoform f
           preproprotein [Homo sapiens]
          Length = 664

 Score =  446 bits (1148), Expect = e-125
 Identities = 239/534 (44%), Positives = 317/534 (59%), Gaps = 19/534 (3%)

Query: 73  QADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQ-VEAVLAGHEAVRWHS 131
           +AD +A A G +N G+IG L+ +Y F     H    +   +  +     L     V+W  
Sbjct: 84  EADRVAAAHGYLNLGQIGNLEDYYHFY----HSKTFKRSTLSSRGPHTFLRMDPQVKWLQ 139

Query: 132 EQRLLRRAKRSV-------HFNDPKYPQQWHLNNRRSPGR---DINVTGVWERNVTGRGV 181
           +Q + RR KR V       +FNDP +   W+L+      R   ++NV   W+R  TG+ V
Sbjct: 140 QQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNV 199

Query: 182 TVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPN 241
            V ++DDG+E    D+APNY    SYD+N ND DP P  D  N N HGTRCAGE+AA  N
Sbjct: 200 VVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASAN 259

Query: 242 NSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPH 301
           NS+C VG+AY ++I GIR+LDG +TD +EA +        DIYS SWGPDDDGKTVDGP 
Sbjct: 260 NSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPG 319

Query: 302 QLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMP 361
           +L K A ++G+  GRQG GSIFV ASGNGG+  D C+ DGY NSIYT+++ +  E G  P
Sbjct: 320 RLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKP 379

Query: 362 FYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQ 421
           +Y EECAS LA T+S G    R IVTTD   +    CT+GHTGTS +AP+ AG+IAL L+
Sbjct: 380 WYLEECASTLATTYSSGAFYERKIVTTDLRQR----CTDGHTGTSVSAPMVAGIIALALE 435

Query: 422 VRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTS 481
               LTWRDVQH++V T+     + ++W  N AG   SH +GFGL++A  LV  AK WT+
Sbjct: 436 ANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTA 495

Query: 482 VPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGS 541
           VP     V+   K  ++IP            +  +     +  LEHV V  SI+HPRRG 
Sbjct: 496 VPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGD 555

Query: 542 LELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDV 595
           L++ L  PSG  S + A R +D    GF +W F TV CWGE+A G + L I+D+
Sbjct: 556 LQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDL 609


>gi|20336190 paired basic amino acid cleaving system 4 isoform d
           preproprotein [Homo sapiens]
          Length = 652

 Score =  446 bits (1148), Expect = e-125
 Identities = 239/534 (44%), Positives = 317/534 (59%), Gaps = 19/534 (3%)

Query: 73  QADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQ-VEAVLAGHEAVRWHS 131
           +AD +A A G +N G+IG L+ +Y F     H    +   +  +     L     V+W  
Sbjct: 84  EADRVAAAHGYLNLGQIGNLEDYYHFY----HSKTFKRSTLSSRGPHTFLRMDPQVKWLQ 139

Query: 132 EQRLLRRAKRSV-------HFNDPKYPQQWHLNNRRSPGR---DINVTGVWERNVTGRGV 181
           +Q + RR KR V       +FNDP +   W+L+      R   ++NV   W+R  TG+ V
Sbjct: 140 QQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNV 199

Query: 182 TVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPN 241
            V ++DDG+E    D+APNY    SYD+N ND DP P  D  N N HGTRCAGE+AA  N
Sbjct: 200 VVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASAN 259

Query: 242 NSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPH 301
           NS+C VG+AY ++I GIR+LDG +TD +EA +        DIYS SWGPDDDGKTVDGP 
Sbjct: 260 NSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPG 319

Query: 302 QLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMP 361
           +L K A ++G+  GRQG GSIFV ASGNGG+  D C+ DGY NSIYT+++ +  E G  P
Sbjct: 320 RLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKP 379

Query: 362 FYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQ 421
           +Y EECAS LA T+S G    R IVTTD   +    CT+GHTGTS +AP+ AG+IAL L+
Sbjct: 380 WYLEECASTLATTYSSGAFYERKIVTTDLRQR----CTDGHTGTSVSAPMVAGIIALALE 435

Query: 422 VRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTS 481
               LTWRDVQH++V T+     + ++W  N AG   SH +GFGL++A  LV  AK WT+
Sbjct: 436 ANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTA 495

Query: 482 VPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGS 541
           VP     V+   K  ++IP            +  +     +  LEHV V  SI+HPRRG 
Sbjct: 496 VPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGD 555

Query: 542 LELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDV 595
           L++ L  PSG  S + A R +D    GF +W F TV CWGE+A G + L I+D+
Sbjct: 556 LQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDL 609


>gi|4505579 furin preproprotein [Homo sapiens]
          Length = 794

 Score =  427 bits (1097), Expect = e-119
 Identities = 254/652 (38%), Positives = 355/652 (54%), Gaps = 41/652 (6%)

Query: 34  WVMGLAGT-----GGPDGQGTGGPSWAVHLESLEGDGEEETLEQQADALAQAAGLVNAGR 88
           WV+   GT         GQ     +WAV +               A+++A+  G +N G+
Sbjct: 9   WVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPA---------VANSVARKHGFLNLGQ 59

Query: 89  IGELQGHYLFVQPAGHRPALEVEAIRQQVEAVLAGHEAVRWHSEQRLLRRAKRSVHFN-- 146
           I     +Y F      + +L     R    + L     V+W  +Q   RR KR V+    
Sbjct: 60  I--FGDYYHFWHRGVTKRSLSPHRPRH---SRLQREPQVQWLEQQVAKRRTKRDVYQEPT 114

Query: 147 DPKYPQQWHLNNRRSPGRDINVTGVWERNVTGRGVTVVVVDDGVEHTIQDIAPNYSPEGS 206
           DPK+PQQW+L+      RD+NV   W +  TG G+ V ++DDG+E    D+A NY P  S
Sbjct: 115 DPKFPQQWYLSGVTQ--RDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGAS 172

Query: 207 YDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLDGPLT 266
           +D+N  DPDP P     N N HGTRCAGE+AAV NN  C VGVAY +RI G+R+LDG +T
Sbjct: 173 FDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVT 232

Query: 267 DSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRQGFGSIFVVA 326
           D++EA +   +     IYS SWGP+DDGKTVDGP +L + A   GV  GR G GSIFV A
Sbjct: 233 DAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWA 292

Query: 327 SGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIV 386
           SGNGG+ +D+CN DGY NSIYT++I +  + G +P+Y+E C+S LA T+S G++  + IV
Sbjct: 293 SGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIV 352

Query: 387 TTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRR 446
           TTD   +    CTE HTGTSA+APLAAG+IAL L+    LTWRD+QH++V T+       
Sbjct: 353 TTDLRQK----CTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNA 408

Query: 447 AEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAIPQSPRSL 506
            +W TN  G   SH +G+GLL+A  +V  A+ WT+V      +  +L E K I    + L
Sbjct: 409 NDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDI---GKRL 465

Query: 507 EVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDP 566
           EV   V+    E + +  LEH    +++++ RRG L + L  P G  S + A R  D   
Sbjct: 466 EVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSA 525

Query: 567 NGFNDWTFSTVRCWGERARGTYRLVIRDVGDESFQVGILRQWQLTLYGSVWSAVDIRDRQ 626
           +GFNDW F T   W E   G + L I +   E+   G L ++ L LYG+    + +    
Sbjct: 526 DGFNDWAFMTTHSWDEDPSGEWVLEIENT-SEANNYGTLTKFTLVLYGTAPEGLPVPPES 584

Query: 627 ---RLLESAMSGKYLHDDFAL-------PCPPGLKIPEEDGYTITPNTLKTL 668
              + L S+ +     + F+L        CPPG      D +  T N ++T+
Sbjct: 585 SGCKTLTSSQACVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETI 636


>gi|20336242 proprotein convertase subtilisin/kexin type 1
           preproprotein [Homo sapiens]
          Length = 753

 Score =  425 bits (1092), Expect = e-119
 Identities = 241/562 (42%), Positives = 333/562 (59%), Gaps = 29/562 (5%)

Query: 72  QQADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQVEAVLAGHEAVRWHS 131
           + A A+A+  G    G+IG L+ HYLF +   H       A    +   L+  + V W  
Sbjct: 44  EAASAIAEELGYDLLGQIGSLENHYLF-KHKNHPRRSRRSAFH--ITKRLSDDDRVIWAE 100

Query: 132 EQRLLRRAKRSVH-------FNDPKYPQQWHLNNRRS----PGRDINVTGVWERNVTGRG 180
           +Q    R+KRS         FNDP + QQW+L + R     P  D++V  VW++ +TG+G
Sbjct: 101 QQYEKERSKRSALRDSALNLFNDPMWNQQWYLQDTRMTAALPKLDLHVIPVWQKGITGKG 160

Query: 181 VTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVP 240
           V + V+DDG+E    DI  NY PE SYD N ND DP P  D  N N HGTRCAGEIA   
Sbjct: 161 VVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHDPFPRYDPTNENKHGTRCAGEIAMQA 220

Query: 241 NNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGP 300
           NN  C VGVAY S++ GIR+LDG +TD++EA +   +    DIYS SWGP+DDGKTV+GP
Sbjct: 221 NNHKCGVGVAYNSKVGGIRMLDGIVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTVEGP 280

Query: 301 HQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRM 360
            +L + A ++GV  GRQG GSIFV ASGNGG+  DNC+ DGY +SIYT++I +  ++G  
Sbjct: 281 GRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLS 340

Query: 361 PFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALML 420
           P+YAE+C+S LA ++S GD   + I + D        CTE HTGTSA+APLAAG+ AL L
Sbjct: 341 PWYAEKCSSTLATSYSSGDYTDQRITSADLH----NDCTETHTGTSASAPLAAGIFALAL 396

Query: 421 QVRPCLTWRDVQHIIVFTATRYED--RRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAA-- 476
           +  P LTWRD+QH++V+T + Y+       W  N AG   + + GFGLLNA  LV+ A  
Sbjct: 397 EANPNLTWRDMQHLVVWT-SEYDPLANNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADP 455

Query: 477 KIWTSVPYLASYVSPVLKENKAIPQSPRSL-EVLWNVSRMDLE--MSGLKTLEHVAVTVS 533
           + W SVP        V+K+N   P++ ++  EV+  +     E   + +K+LEHV    +
Sbjct: 456 RTWRSVP---EKKECVVKDNDFEPRALKANGEVIIEIPTRACEGQENAIKSLEHVQFEAT 512

Query: 534 ITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIR 593
           I + RRG L + L   +G  +++ A R  D+ PNGF +W F +V  WGE   GT+ L I 
Sbjct: 513 IEYSRRGDLHVTLTSAAGTSTVLLAERERDTSPNGFKNWDFMSVHTWGENPIGTWTLRIT 572

Query: 594 DVGDESFQVGILRQWQLTLYGS 615
           D+       G +  W+L L+G+
Sbjct: 573 DMSGRIQNEGRIVNWKLILHGT 594


>gi|76443679 proprotein convertase subtilisin/kexin type 4 [Homo
           sapiens]
          Length = 755

 Score =  422 bits (1085), Expect = e-118
 Identities = 253/648 (39%), Positives = 357/648 (55%), Gaps = 44/648 (6%)

Query: 18  PTCLWLELA-GLFLLVPWVMGLAGTGGPDGQGTGGPSWAVHLESLEGDGEEETLEQQADA 76
           P  LWL L   L L+ P  +G A    P        SWAV +   +G+ E E L      
Sbjct: 5   PIALWLRLVLALALVRPRAVGWAPVRAPIYVS----SWAVQVS--QGNREVERL------ 52

Query: 77  LAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQVEAV-LAGHEAVRWHSEQRL 135
            A+  G VN G I    G Y  ++   HR  ++          + L  +  V+W  +Q L
Sbjct: 53  -ARKFGFVNLGPIFP-DGQYFHLR---HRGVVQQSLTPHWGHRLHLKKNPKVQWFQQQTL 107

Query: 136 LRRAKRSVHF-NDPKYPQQWHLNNRRSPGRDINVTGVWERNVTGRGVTVVVVDDGVEHTI 194
            RR KRSV    DP + +QW++N+   P  D+++   W + ++G+G+ V V+DDG+E   
Sbjct: 108 QRRVKRSVVVPTDPWFSKQWYMNSEAQP--DLSILQAWSQGLSGQGIVVSVLDDGIEKDH 165

Query: 195 QDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSR 254
            D+  NY P  SYD N  DPDP P       N HGTRCAGE+AA+ NN FC VGVA+ +R
Sbjct: 166 PDLWANYDPLASYDFNDYDPDPQPRYTPSKENRHGTRCAGEVAAMANNGFCGVGVAFNAR 225

Query: 255 IAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIA 314
           I G+R+LDG +TD +EA + +   Q   IYS SWGP+DDG+TVDGP  L + A + GV  
Sbjct: 226 IGGVRMLDGTITDVIEAQSLSLQPQHIHIYSASWGPEDDGRTVDGPGILTREAFRRGVTK 285

Query: 315 GRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVT 374
           GR G G++F+ ASGNGG H DNCN DGY NSI+T+++G+  ++GR+P+Y+E CAS L  T
Sbjct: 286 GRGGLGTLFIWASGNGGLHYDNCNCDGYTNSIHTLSVGSTTQQGRVPWYSEACASTLTTT 345

Query: 375 FSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHI 434
           +S G      IVTTD       GCT+ HTGTSA+APLAAGMIAL L+  P LTWRD+QH+
Sbjct: 346 YSSGVATDPQIVTTDLH----HGCTDQHTGTSASAPLAAGMIALALEANPFLTWRDMQHL 401

Query: 435 IVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLK 494
           +V  +     +  +W TN  G   SH +G+GLL+A  LV+ A+ W  +P        V  
Sbjct: 402 VVRASKPAHLQAEDWRTNGVGRQVSHHYGYGLLDAGLLVDTARTW--LPTQPQRKCAVRV 459

Query: 495 ENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMS 554
           +++  P  P  + +  NVS      + +++LEHV   +++++ RRG LE+ L  P G  S
Sbjct: 460 QSRPTPILP-LIYIRENVSACAGLHNSIRSLEHVQAQLTLSYSRRGDLEISLTSPMGTRS 518

Query: 555 LIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDESFQVGILRQWQLTLYG 614
            + A R +D    G+N+W F +   W E  +G + L + + G   F  G L ++ L LYG
Sbjct: 519 TLVAIRPLDVSTEGYNNWVFMSTHFWDENPQGVWTLGLENKG-YYFNTGTLYRYTLLLYG 577

Query: 615 S-------------VWSAVDIRDRQRLLESAMSGKYLHDDFALP-CPP 648
           +               SA   RD + L ++     Y+     L  CPP
Sbjct: 578 TAEDMTARPTGPQVTSSACVQRDTEGLCQACDGPAYILGQLCLAYCPP 625


>gi|20336244 proprotein convertase subtilisin/kexin type 2 [Homo
           sapiens]
          Length = 638

 Score =  377 bits (967), Expect = e-104
 Identities = 206/481 (42%), Positives = 290/481 (60%), Gaps = 13/481 (2%)

Query: 143 VHFNDPKYPQQWHLNNRR----SPGRDINVTGVWERNVTGRGVTVVVVDDGVEHTIQDIA 198
           ++ NDP + +QW+L N      +PG D+NV   WE   TG+GVT+ ++DDG+++   D+A
Sbjct: 119 INMNDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLA 178

Query: 199 PNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGI 258
            NY+ E SYD +SNDP P P    +  N HGTRCAGE++A  NN+ C VGVAY S++AGI
Sbjct: 179 SNYNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGI 238

Query: 259 RVLDGP-LTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRQ 317
           R+LD P +TD +EA + +   Q+ DIYS SWGP D+GKTVDGP +L   A+  GV  GR 
Sbjct: 239 RMLDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRG 298

Query: 318 GFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSG 377
           G GSI+V ASG+GG + D+CN DGYA+S++T++I +   +GR   Y E C+S LA TFS 
Sbjct: 299 GKGSIYVWASGDGGSY-DDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSN 357

Query: 378 GDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVF 437
           G K          DL     CT  H+GTSAAAP AAG+ AL L+    LTWRD+QH+ V 
Sbjct: 358 GRKRNPEAGVATTDLY--GNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVL 415

Query: 438 TATRYE--DRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKE 495
           T+ R +  D   +W  N  G   +H  G+G+L+A  +V  AK W +VP     V   +++
Sbjct: 416 TSKRNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQD 475

Query: 496 NKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSL 555
            + IP S   L +       + + + ++ LEHV   +++   RRG L + +  P G  S+
Sbjct: 476 PEKIP-STGKLVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSI 534

Query: 556 IGAPRSMDSDPN-GFNDWTFSTVRCWGERARGTYRLVIRDVGDESFQVGILRQWQLTLYG 614
           + + R  D D   GF+ W F T   WGE ARGT+ L +  VG    Q G+L++W L L+G
Sbjct: 535 LLSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAP-QKGVLKEWTLMLHG 593

Query: 615 S 615
           +
Sbjct: 594 T 594


>gi|20336186 paired basic amino acid cleaving system 4 isoform c
           preproprotein [Homo sapiens]
          Length = 487

 Score =  355 bits (912), Expect = 7e-98
 Identities = 184/394 (46%), Positives = 242/394 (61%), Gaps = 19/394 (4%)

Query: 73  QADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQ-VEAVLAGHEAVRWHS 131
           +AD +A A G +N G+IG L+ +Y F     H    +   +  +     L     V+W  
Sbjct: 84  EADRVAAAHGYLNLGQIGNLEDYYHFY----HSKTFKRSTLSSRGPHTFLRMDPQVKWLQ 139

Query: 132 EQRLLRRAKRSV-------HFNDPKYPQQWHLNNRRSPGR---DINVTGVWERNVTGRGV 181
           +Q + RR KR V       +FNDP +   W+L+      R   ++NV   W+R  TG+ V
Sbjct: 140 QQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNV 199

Query: 182 TVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPN 241
            V ++DDG+E    D+APNY    SYD+N ND DP P  D  N N HGTRCAGE+AA  N
Sbjct: 200 VVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASAN 259

Query: 242 NSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPH 301
           NS+C VG+AY ++I GIR+LDG +TD +EA +        DIYS SWGPDDDGKTVDGP 
Sbjct: 260 NSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPG 319

Query: 302 QLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMP 361
           +L K A ++G+  GRQG GSIFV ASGNGG+  D C+ DGY NSIYT+++ +  E G  P
Sbjct: 320 RLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKP 379

Query: 362 FYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQ 421
           +Y EECAS LA T+S G    R IVTTD   +    CT+GHTGTS +AP+ AG+IAL L+
Sbjct: 380 WYLEECASTLATTYSSGAFYERKIVTTDLRQR----CTDGHTGTSVSAPMVAGIIALALE 435

Query: 422 VRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAG 455
               LTWRDVQH++V T+     + ++W  N AG
Sbjct: 436 ANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAG 469


>gi|31317307 proprotein convertase subtilisin/kexin type 9
           preproprotein [Homo sapiens]
          Length = 692

 Score = 36.2 bits (82), Expect = 0.12
 Identities = 58/232 (25%), Positives = 94/232 (40%), Gaps = 39/232 (16%)

Query: 219 HPDVENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLD----GPLTDSMEAVAF 274
           H      + HGT  AG ++          GVA G+ +  +RVL+    G ++ ++  + F
Sbjct: 217 HRQASKCDSHGTHLAGVVSGRD------AGVAKGASMRSLRVLNCQGKGTVSGTLIGLEF 270

Query: 275 NKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHN 334
            +  Q+        GP      V  P   G + + +         G + V A+GN    +
Sbjct: 271 IRKSQLVQPV----GP----LVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNF--RD 320

Query: 335 DNCNYDGYANSIYTVTIGAVDEE------GRMPFYAEECASMLAVTFSGGDKMLRSIVTT 388
           D C Y   A++   +T+GA + +      G +      C  + A    G D     I+  
Sbjct: 321 DACLYSP-ASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFA---PGED-----IIGA 371

Query: 389 DWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDV-QHIIVFTA 439
             D      C    +GTS AA   AG+ A+ML   P LT  ++ Q +I F+A
Sbjct: 372 SSDCST---CFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSA 420


>gi|65288071 tensin 3 [Homo sapiens]
          Length = 1445

 Score = 34.7 bits (78), Expect = 0.35
 Identities = 17/54 (31%), Positives = 27/54 (50%), Gaps = 5/54 (9%)

Query: 265  LTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRQG 318
            LTD+   + F +HY +N +  C+  P D     DGP     ++   G +A +QG
Sbjct: 1360 LTDNQRKLFFRRHYPVNSVIFCALDPQDRKWIKDGP-----SSKVFGFVARKQG 1408


>gi|4506775 membrane-bound transcription factor site-1 protease
           preproprotein [Homo sapiens]
          Length = 1052

 Score = 34.3 bits (77), Expect = 0.46
 Identities = 91/397 (22%), Positives = 146/397 (36%), Gaps = 83/397 (20%)

Query: 128 RWHSEQRLLRRAKRSVHFNDPKYPQQWHLNNRRSPGR-----------DINVTGVWERNV 176
           +W S  R LRRA  S+          WH   R S  R            +    +W+   
Sbjct: 155 KWQSS-RPLRRASLSLGSGF------WHATGRHSSRRLLRAIPRQVAQTLQADVLWQMGY 207

Query: 177 TGRGVTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEI 236
           TG  V V V D G    + +  P++         +N+        +++G  HGT  AG I
Sbjct: 208 TGANVRVAVFDTG----LSEKHPHFKNVKERTNWTNERT------LDDGLGHGTFVAGVI 257

Query: 237 AAVPNNSFCAVGVAYGSRIAGIRVLDGPLTD--SMEAVAFNKHYQIN---DIYSCSWGPD 291
           A++        G A  + +   RV         S    AFN  Y I    D+ + S G  
Sbjct: 258 ASMRE----CQGFAPDAELHIFRVFTNNQVSYTSWFLDAFN--YAILKKIDVLNLSIGGP 311

Query: 292 D--DGKTVDGPHQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTV 349
           D  D   VD   +L    +             I V A GN G      N    A+ +  +
Sbjct: 312 DFMDHPFVDKVWELTANNV-------------IMVSAIGNDGPLYGTLNNP--ADQMDVI 356

Query: 350 TIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGH---TGTS 406
            +G +D E  +  ++     M      GG   ++  + T     +G+G   G    +GTS
Sbjct: 357 GVGGIDFEDNIARFSSR--GMTTWELPGGYGRMKPDIVTYGAGVRGSGVKGGCRALSGTS 414

Query: 407 AAAPLAAGMIALM---LQVRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHG 463
            A+P+ AG + L+   +Q R  +    ++  ++ +A R        +     F   H   
Sbjct: 415 VASPVVAGAVTLLVSTVQKRELVNPASMKQALIASARR--------LPGVNMFEQGHGK- 465

Query: 464 FGLLNAWRLVNAAKIWTSV----------PYLASYVS 490
             LL A++++N+ K   S+          PY+  Y S
Sbjct: 466 LDLLRAYQILNSYKPQASLSPSYIDLTECPYMWPYCS 502


>gi|20070331 oxysterol binding protein-like 9 isoform e [Homo
           sapiens]
          Length = 736

 Score = 32.3 bits (72), Expect = 1.7
 Identities = 35/136 (25%), Positives = 53/136 (38%), Gaps = 20/136 (14%)

Query: 264 PLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAAL------QHGVIAGRQ 317
           P   +  A  FNK  Q N   +  W          G H +G+  +      +H ++    
Sbjct: 503 PPISAFYAECFNKKIQFN---AHIWTKSKFLGMSIGVHNIGQGCVSCLDYDEHYILTFPN 559

Query: 318 GFG-SIFVVASGN-GGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTF 375
           G+G SI  V     GG+ N NC+  GY+ +I   T          PFY  +   + A  F
Sbjct: 560 GYGRSILTVPWVELGGECNINCSKTGYSANIIFHT---------KPFYGGKKHRITAEIF 610

Query: 376 SGGDKMLRSIVTTDWD 391
           S  DK     +  +W+
Sbjct: 611 SPNDKKSFCSIEGEWN 626


>gi|22547176 oxysterol binding protein-like 9 isoform f [Homo
           sapiens]
          Length = 746

 Score = 32.3 bits (72), Expect = 1.7
 Identities = 35/136 (25%), Positives = 53/136 (38%), Gaps = 20/136 (14%)

Query: 264 PLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAAL------QHGVIAGRQ 317
           P   +  A  FNK  Q N   +  W          G H +G+  +      +H ++    
Sbjct: 513 PPISAFYAECFNKKIQFN---AHIWTKSKFLGMSIGVHNIGQGCVSCLDYDEHYILTFPN 569

Query: 318 GFG-SIFVVASGN-GGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTF 375
           G+G SI  V     GG+ N NC+  GY+ +I   T          PFY  +   + A  F
Sbjct: 570 GYGRSILTVPWVELGGECNINCSKTGYSANIIFHT---------KPFYGGKKHRITAEIF 620

Query: 376 SGGDKMLRSIVTTDWD 391
           S  DK     +  +W+
Sbjct: 621 SPNDKKSFCSIEGEWN 636


>gi|22547173 oxysterol binding protein-like 9 isoform d [Homo
           sapiens]
          Length = 723

 Score = 32.3 bits (72), Expect = 1.7
 Identities = 35/136 (25%), Positives = 53/136 (38%), Gaps = 20/136 (14%)

Query: 264 PLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAAL------QHGVIAGRQ 317
           P   +  A  FNK  Q N   +  W          G H +G+  +      +H ++    
Sbjct: 490 PPISAFYAECFNKKIQFN---AHIWTKSKFLGMSIGVHNIGQGCVSCLDYDEHYILTFPN 546

Query: 318 GFG-SIFVVASGN-GGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTF 375
           G+G SI  V     GG+ N NC+  GY+ +I   T          PFY  +   + A  F
Sbjct: 547 GYGRSILTVPWVELGGECNINCSKTGYSANIIFHT---------KPFYGGKKHRITAEIF 597

Query: 376 SGGDKMLRSIVTTDWD 391
           S  DK     +  +W+
Sbjct: 598 SPNDKKSFCSIEGEWN 613


>gi|22547171 oxysterol binding protein-like 9 isoform c [Homo
           sapiens]
          Length = 626

 Score = 32.3 bits (72), Expect = 1.7
 Identities = 35/136 (25%), Positives = 53/136 (38%), Gaps = 20/136 (14%)

Query: 264 PLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAAL------QHGVIAGRQ 317
           P   +  A  FNK  Q N   +  W          G H +G+  +      +H ++    
Sbjct: 393 PPISAFYAECFNKKIQFN---AHIWTKSKFLGMSIGVHNIGQGCVSCLDYDEHYILTFPN 449

Query: 318 GFG-SIFVVASGN-GGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTF 375
           G+G SI  V     GG+ N NC+  GY+ +I   T          PFY  +   + A  F
Sbjct: 450 GYGRSILTVPWVELGGECNINCSKTGYSANIIFHT---------KPFYGGKKHRITAEIF 500

Query: 376 SGGDKMLRSIVTTDWD 391
           S  DK     +  +W+
Sbjct: 501 SPNDKKSFCSIEGEWN 516


>gi|22547169 oxysterol binding protein-like 9 isoform b [Homo
           sapiens]
          Length = 571

 Score = 32.3 bits (72), Expect = 1.7
 Identities = 35/136 (25%), Positives = 53/136 (38%), Gaps = 20/136 (14%)

Query: 264 PLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAAL------QHGVIAGRQ 317
           P   +  A  FNK  Q N   +  W          G H +G+  +      +H ++    
Sbjct: 338 PPISAFYAECFNKKIQFN---AHIWTKSKFLGMSIGVHNIGQGCVSCLDYDEHYILTFPN 394

Query: 318 GFG-SIFVVASGN-GGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTF 375
           G+G SI  V     GG+ N NC+  GY+ +I   T          PFY  +   + A  F
Sbjct: 395 GYGRSILTVPWVELGGECNINCSKTGYSANIIFHT---------KPFYGGKKHRITAEIF 445

Query: 376 SGGDKMLRSIVTTDWD 391
           S  DK     +  +W+
Sbjct: 446 SPNDKKSFCSIEGEWN 461


>gi|22547167 oxysterol binding protein-like 9 isoform a [Homo
           sapiens]
          Length = 558

 Score = 32.3 bits (72), Expect = 1.7
 Identities = 35/136 (25%), Positives = 53/136 (38%), Gaps = 20/136 (14%)

Query: 264 PLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAAL------QHGVIAGRQ 317
           P   +  A  FNK  Q N   +  W          G H +G+  +      +H ++    
Sbjct: 325 PPISAFYAECFNKKIQFN---AHIWTKSKFLGMSIGVHNIGQGCVSCLDYDEHYILTFPN 381

Query: 318 GFG-SIFVVASGN-GGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTF 375
           G+G SI  V     GG+ N NC+  GY+ +I   T          PFY  +   + A  F
Sbjct: 382 GYGRSILTVPWVELGGECNINCSKTGYSANIIFHT---------KPFYGGKKHRITAEIF 432

Query: 376 SGGDKMLRSIVTTDWD 391
           S  DK     +  +W+
Sbjct: 433 SPNDKKSFCSIEGEWN 448


>gi|22547165 oxysterol binding protein-like 9 isoform a [Homo
           sapiens]
          Length = 558

 Score = 32.3 bits (72), Expect = 1.7
 Identities = 35/136 (25%), Positives = 53/136 (38%), Gaps = 20/136 (14%)

Query: 264 PLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAAL------QHGVIAGRQ 317
           P   +  A  FNK  Q N   +  W          G H +G+  +      +H ++    
Sbjct: 325 PPISAFYAECFNKKIQFN---AHIWTKSKFLGMSIGVHNIGQGCVSCLDYDEHYILTFPN 381

Query: 318 GFG-SIFVVASGN-GGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTF 375
           G+G SI  V     GG+ N NC+  GY+ +I   T          PFY  +   + A  F
Sbjct: 382 GYGRSILTVPWVELGGECNINCSKTGYSANIIFHT---------KPFYGGKKHRITAEIF 432

Query: 376 SGGDKMLRSIVTTDWD 391
           S  DK     +  +W+
Sbjct: 433 SPNDKKSFCSIEGEWN 448


>gi|33286442 BCL6 co-repressor-like 1 [Homo sapiens]
          Length = 1711

 Score = 31.2 bits (69), Expect = 3.9
 Identities = 23/77 (29%), Positives = 31/77 (40%), Gaps = 8/77 (10%)

Query: 701 SGPCHWPHRSRKAKEEGTELESVPLCSSKDPDEVETESRGPPTTSDLLAPDLLEQGDWSL 760
           S P H P +     E+ TE  SV     K P ++E E   PP  S++         D S 
Sbjct: 575 SAPPH-PAKMPSGTEQQTEGTSVTFSPLKSPPQLEREMASPPECSEMPL-------DLSS 626

Query: 761 SQNKSALDCPHQHLDVP 777
             N+  L  P+Q    P
Sbjct: 627 KSNRQKLPLPNQRKTPP 643


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score = 30.8 bits (68), Expect = 5.1
 Identities = 27/85 (31%), Positives = 40/85 (47%), Gaps = 4/85 (4%)

Query: 55   AVHLESLEGDGEEETLEQQADALAQA---AGLVNAGRIGELQGHYLFVQPAGHRPALEVE 111
            A+  E  +  G+EE ++++ADAL  A   A +    R GELQ H    +      A+E  
Sbjct: 1821 ALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGR 1880

Query: 112  AIRQQVEAVLAGHEAVRWHSEQRLL 136
             + Q +E VL    A     E+ LL
Sbjct: 1881 RV-QALEEVLGDLRAESREQEKALL 1904


>gi|214830451 sequestosome 1 isoform 2 [Homo sapiens]
          Length = 356

 Score = 30.8 bits (68), Expect = 5.1
 Identities = 20/71 (28%), Positives = 32/71 (45%), Gaps = 2/71 (2%)

Query: 699 CRSGPCHWPHRSRKAKEEGT-ELESVPLCSSKDPDEVETESRGPPTTSD-LLAPDLLEQG 756
           C  G   W H S K  +  T EL+S+ +  S+ P  ++    GP    +  L P L  + 
Sbjct: 247 CSGGDDDWTHLSSKEVDPSTGELQSLQMPESEGPSSLDPSQEGPTGLKEAALYPHLPPEA 306

Query: 757 DWSLSQNKSAL 767
           D  L ++ S +
Sbjct: 307 DPRLIESLSQM 317


>gi|214830438 sequestosome 1 isoform 2 [Homo sapiens]
          Length = 356

 Score = 30.8 bits (68), Expect = 5.1
 Identities = 20/71 (28%), Positives = 32/71 (45%), Gaps = 2/71 (2%)

Query: 699 CRSGPCHWPHRSRKAKEEGT-ELESVPLCSSKDPDEVETESRGPPTTSD-LLAPDLLEQG 756
           C  G   W H S K  +  T EL+S+ +  S+ P  ++    GP    +  L P L  + 
Sbjct: 247 CSGGDDDWTHLSSKEVDPSTGELQSLQMPESEGPSSLDPSQEGPTGLKEAALYPHLPPEA 306

Query: 757 DWSLSQNKSAL 767
           D  L ++ S +
Sbjct: 307 DPRLIESLSQM 317


>gi|4505571 sequestosome 1 isoform 1 [Homo sapiens]
          Length = 440

 Score = 30.8 bits (68), Expect = 5.1
 Identities = 20/71 (28%), Positives = 32/71 (45%), Gaps = 2/71 (2%)

Query: 699 CRSGPCHWPHRSRKAKEEGT-ELESVPLCSSKDPDEVETESRGPPTTSD-LLAPDLLEQG 756
           C  G   W H S K  +  T EL+S+ +  S+ P  ++    GP    +  L P L  + 
Sbjct: 331 CSGGDDDWTHLSSKEVDPSTGELQSLQMPESEGPSSLDPSQEGPTGLKEAALYPHLPPEA 390

Query: 757 DWSLSQNKSAL 767
           D  L ++ S +
Sbjct: 391 DPRLIESLSQM 401


>gi|94536852 transmembrane cochlear-expressed protein 2 [Homo
           sapiens]
          Length = 906

 Score = 30.8 bits (68), Expect = 5.1
 Identities = 28/96 (29%), Positives = 41/96 (42%), Gaps = 9/96 (9%)

Query: 668 LVLVGCFTVFWTVYYMLEVY--LSQRNVASN---QVCRSGPCHWPHRSRKAKEEGTELES 722
           L++     +F  +YY+  V   LS+ N       QV R       H+S K K    + E 
Sbjct: 760 LIIPAILLMFLAIYYLNSVSKSLSRANAQLRKKIQVLRE--VEKSHKSVKGKATARDSED 817

Query: 723 VPLCSSKDPDEVE--TESRGPPTTSDLLAPDLLEQG 756
            P  SSK+  +++   E   PP+ S   A D   QG
Sbjct: 818 TPKSSSKNATQLQLTKEETTPPSASQSQAMDKKAQG 853


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.135    0.427 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,170,887
Number of Sequences: 37866
Number of extensions: 1682414
Number of successful extensions: 4256
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 16
Number of HSP's successfully gapped in prelim test: 19
Number of HSP's that attempted gapping in prelim test: 4174
Number of HSP's gapped (non-prelim): 39
length of query: 785
length of database: 18,247,518
effective HSP length: 110
effective length of query: 675
effective length of database: 14,082,258
effective search space: 9505524150
effective search space used: 9505524150
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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