Guide to the Human Genome
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Name: PCSK9 Sequence: fasta or formatted (692aa) NCBI GI: 31317307
Description:

proprotein convertase subtilisin/kexin type 9 preproprotein

Referenced in:

Peptide-processing Enzymes

Composition:

amino acid map
 Amino acid        Percentage    Count  Longest homopolymer
 A alanine            10.7         74           3
 C cysteine            3.8         26           2
 D aspartate           4.0         28           2
 E glutamate           6.6         46           2
 F phenylalanine       2.3         16           1
 G glycine             8.8         61           2
 H histidine           3.9         27           1
 I isoleucine          2.6         18           2
 K lysine              2.2         15           1
 L leucine            10.4         72           9
 M methionine          1.3          9           2
 N asparagine          1.9         13           1
 P proline             5.6         39           2
 Q glutamine           4.3         30           2
 R arginine            6.8         47           2
 S serine              7.7         53           2
 T threonine           6.1         42           2
 V valine              8.1         56           3
 W tryptophan          1.3          9           2
 Y tyrosine            1.6         11           1
Comparative genomics:

Search single species RefSeq proteins at NCBI
   H. sapiens
   M. musculus
   D. rerio
   C. intestinalis
   S. purpuratus
   D. melanogaster
   C. elegans
   A. thaliana
   S. cerevisiae
   E. coli W3110
   A. pernix K1

Search summary

comparative genomics plot

   Figure data

Additional searches of
RefSeq proteins at NCBI

   All
   Eukaryotes
   Bacteria
   Archaea
   Viruses
   Primates
   Mammals
   Vertebrates

Related human proteins:
Protein          Relative score         Description

Self-match            1.000   proprotein convertase subtilisin/kexin type 9 prepro... 
MBTPS1                0.010   membrane-bound transcription factor site-1 protease p...
PCSK7                 0.008   proprotein convertase subtilisin/kexin type 7 prepro...
FURIN                 0.007   furin preproprotein 
LOC100294460          0.007   PREDICTED: similar to ATPase, Ca++ transporting, fa...
PCSK6                 0.006   paired basic amino acid cleaving system 4 isoform e ...
PCSK6                 0.006   paired basic amino acid cleaving system 4 isoform c ...
PCSK6                 0.006   paired basic amino acid cleaving system 4 isoform f ...
PCSK6                 0.006   paired basic amino acid cleaving system 4 isoform d ...
PCSK6                 0.006   paired basic amino acid cleaving system 4 isoform h ...
PCSK6                 0.006   paired basic amino acid cleaving system 4 isoform g ...
PCSK6                 0.006   paired basic amino acid cleaving system 4 isoform a p...
PCSK6                 0.006   paired basic amino acid cleaving system 4 isoform b ...
PCSK1                 0.006   proprotein convertase subtilisin/kexin type 1 prepro...
PPP2R5D               0.005   delta isoform of regulatory subunit B56, protein pho...
PPP2R5D               0.005   delta isoform of regulatory subunit B56, protein pho...
PPP2R5D               0.005   delta isoform of regulatory subunit B56, protein phos...
APC2                  0.005   adenomatosis polyposis coli 2 
TPP2                  0.004   tripeptidyl peptidase II 
PCSK5                 0.004   proprotein convertase subtilisin/kexin type 5 prepro...
PCSK2                 0.004   proprotein convertase subtilisin/kexin type 2 
FCAMR                 0.004   Fc receptor, IgA, IgM, high affinity isoform 1 [Hom...
FCAMR                 0.004   Fc receptor, IgA, IgM, high affinity isoform 1 [Hom...
STAB1                 0.004   stabilin 1 precursor 
MEGF8                 0.004   multiple EGF-like-domains 8 
HECW1                 0.004   NEDD4-like ubiquitin-protein ligase 1 
PIGT                  0.004   phosphatidylinositol glycan anchor biosynthesis, cla...
ZNF687                0.004   zinc finger protein 687 
AZGP1                 0.004   alpha-2-glycoprotein 1, zinc 
SCT                   0.004   secretin preproprotein 
Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.


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Guide to the Human Genome
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