Guide to the Human Genome
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Search of human proteins with 20143973

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|20143973 hedgehog-interacting protein [Homo sapiens]
         (700 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|20143973 hedgehog-interacting protein [Homo sapiens]              1466   0.0  
gi|124248546 HHIP-like 2 [Homo sapiens]                               270   3e-72
gi|187936955 HHIP-like protein 1 isoform a [Homo sapiens]             257   3e-68
gi|187936953 HHIP-like protein 1 isoform b [Homo sapiens]             247   3e-65
gi|209571555 von Willebrand factor D and EGF domains [Homo sapiens]    74   4e-13
gi|111125011 WNT inhibitory factor 1 precursor [Homo sapiens]          71   4e-12
gi|66346695 fibrillin 2 precursor [Homo sapiens]                       67   6e-11
gi|56237021 fibrillin 3 precursor [Homo sapiens]                       66   1e-10
gi|148886654 polydom [Homo sapiens]                                    65   2e-10
gi|24430141 fibrillin 1 precursor [Homo sapiens]                       65   3e-10
gi|222352166 nel-like 1 isoform 2 precursor [Homo sapiens]             62   1e-09
gi|222352164 nel-like 1 isoform 1 precursor [Homo sapiens]             62   1e-09
gi|74136023 delta-like 1 homolog [Homo sapiens]                        62   1e-09
gi|45593147 EGF-like-domain, multiple 9 [Homo sapiens]                 62   2e-09
gi|45545431 EGF-like-domain, multiple 9 [Homo sapiens]                 62   2e-09
gi|9506545 delta-like 4 protein precursor [Homo sapiens]               59   1e-08
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]                57   8e-08
gi|145701025 multiple EGF-like-domains 8 [Homo sapiens]                56   1e-07
gi|169790825 odz, odd Oz/ten-m homolog 4 [Homo sapiens]                55   3e-07
gi|21704279 jagged 2 isoform b precursor [Homo sapiens]                54   4e-07
gi|21704277 jagged 2 isoform a precursor [Homo sapiens]                54   4e-07
gi|4557733 latent transforming growth factor beta binding protei...    53   1e-06
gi|223029476 NEL-like protein 2 isoform d [Homo sapiens]               53   1e-06
gi|223029474 NEL-like protein 2 isoform c [Homo sapiens]               53   1e-06
gi|223029472 NEL-like protein 2 isoform b precursor [Homo sapiens]     53   1e-06
gi|223029470 NEL-like protein 2 isoform a [Homo sapiens]               53   1e-06
gi|5453766 NEL-like protein 2 isoform b precursor [Homo sapiens]       53   1e-06
gi|110735443 delta-like 1 [Homo sapiens]                               52   1e-06
gi|134244285 Notch homolog 3 [Homo sapiens]                            52   1e-06
gi|188528648 tenascin XB isoform 1 precursor [Homo sapiens]            52   2e-06

>gi|20143973 hedgehog-interacting protein [Homo sapiens]
          Length = 700

 Score = 1466 bits (3794), Expect = 0.0
 Identities = 700/700 (100%), Positives = 700/700 (100%)

Query: 1   MLKMLSFKLLLLAVALGFFEGDAKFGERNEGSGARRRRCLNGNPPKRLKRRDRRMMSQLE 60
           MLKMLSFKLLLLAVALGFFEGDAKFGERNEGSGARRRRCLNGNPPKRLKRRDRRMMSQLE
Sbjct: 1   MLKMLSFKLLLLAVALGFFEGDAKFGERNEGSGARRRRCLNGNPPKRLKRRDRRMMSQLE 60

Query: 61  LLSGGEMLCGGFYPRLSCCLRSDSPGLGRLENKIFSVTNNTECGKLLEEIKCALCSPHSQ 120
           LLSGGEMLCGGFYPRLSCCLRSDSPGLGRLENKIFSVTNNTECGKLLEEIKCALCSPHSQ
Sbjct: 61  LLSGGEMLCGGFYPRLSCCLRSDSPGLGRLENKIFSVTNNTECGKLLEEIKCALCSPHSQ 120

Query: 121 SLFHSPEREVLERDLVLPLLCKDYCKEFFYTCRGHIPGFLQTTADEFCFYYARKDGGLCF 180
           SLFHSPEREVLERDLVLPLLCKDYCKEFFYTCRGHIPGFLQTTADEFCFYYARKDGGLCF
Sbjct: 121 SLFHSPEREVLERDLVLPLLCKDYCKEFFYTCRGHIPGFLQTTADEFCFYYARKDGGLCF 180

Query: 181 PDFPRKQVRGPASNYLDQMEEYDKVEEISRKHKHNCFCIQEVVSGLRQPVGALHSGDGSQ 240
           PDFPRKQVRGPASNYLDQMEEYDKVEEISRKHKHNCFCIQEVVSGLRQPVGALHSGDGSQ
Sbjct: 181 PDFPRKQVRGPASNYLDQMEEYDKVEEISRKHKHNCFCIQEVVSGLRQPVGALHSGDGSQ 240

Query: 241 RLFILEKEGYVKILTPEGEIFKEPYLDIHKLVQSGIKGGDERGLLSLAFHPNYKKNGKLY 300
           RLFILEKEGYVKILTPEGEIFKEPYLDIHKLVQSGIKGGDERGLLSLAFHPNYKKNGKLY
Sbjct: 241 RLFILEKEGYVKILTPEGEIFKEPYLDIHKLVQSGIKGGDERGLLSLAFHPNYKKNGKLY 300

Query: 301 VSYTTNQERWAIGPHDHILRVVEYTVSRKNPHQVDLRTARVFLEVAELHRKHLGGQLLFG 360
           VSYTTNQERWAIGPHDHILRVVEYTVSRKNPHQVDLRTARVFLEVAELHRKHLGGQLLFG
Sbjct: 301 VSYTTNQERWAIGPHDHILRVVEYTVSRKNPHQVDLRTARVFLEVAELHRKHLGGQLLFG 360

Query: 361 PDGFLYIILGDGMITLDDMEEMDGLSDFTGSVLRLDVDTDMCNVPYSIPRSNPHFNSTNQ 420
           PDGFLYIILGDGMITLDDMEEMDGLSDFTGSVLRLDVDTDMCNVPYSIPRSNPHFNSTNQ
Sbjct: 361 PDGFLYIILGDGMITLDDMEEMDGLSDFTGSVLRLDVDTDMCNVPYSIPRSNPHFNSTNQ 420

Query: 421 PPEVFAHGLHDPGRCAVDRHPTDININLTILCSDSNGKNRSSARILQIIKGKDYESEPSL 480
           PPEVFAHGLHDPGRCAVDRHPTDININLTILCSDSNGKNRSSARILQIIKGKDYESEPSL
Sbjct: 421 PPEVFAHGLHDPGRCAVDRHPTDININLTILCSDSNGKNRSSARILQIIKGKDYESEPSL 480

Query: 481 LEFKPFSNGPLVGGFVYRGCQSERLYGSYVFGDRNGNFLTLQQSPVTKQWQEKPLCLGTS 540
           LEFKPFSNGPLVGGFVYRGCQSERLYGSYVFGDRNGNFLTLQQSPVTKQWQEKPLCLGTS
Sbjct: 481 LEFKPFSNGPLVGGFVYRGCQSERLYGSYVFGDRNGNFLTLQQSPVTKQWQEKPLCLGTS 540

Query: 541 GSCRGYFSGHILGFGEDELGEVYILSSSKSMTQTHNGKLYKIVDPKRPLMPEECRATVQP 600
           GSCRGYFSGHILGFGEDELGEVYILSSSKSMTQTHNGKLYKIVDPKRPLMPEECRATVQP
Sbjct: 541 GSCRGYFSGHILGFGEDELGEVYILSSSKSMTQTHNGKLYKIVDPKRPLMPEECRATVQP 600

Query: 601 AQTLTSECSRLCRNGYCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKG 660
           AQTLTSECSRLCRNGYCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKG
Sbjct: 601 AQTLTSECSRLCRNGYCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKG 660

Query: 661 YLGPQCEQVDRNIRRVTRAGILDQIIDMTSYLLDLTSYIV 700
           YLGPQCEQVDRNIRRVTRAGILDQIIDMTSYLLDLTSYIV
Sbjct: 661 YLGPQCEQVDRNIRRVTRAGILDQIIDMTSYLLDLTSYIV 700


>gi|124248546 HHIP-like 2 [Homo sapiens]
          Length = 724

 Score =  270 bits (691), Expect = 3e-72
 Identities = 180/552 (32%), Positives = 269/552 (48%), Gaps = 65/552 (11%)

Query: 95  FSVTNNTECGKLLEEIKCALCSPHSQSLFHSPEREVLERDLVLPLLCKDYCKEFFYTCRG 154
           F +  +  CG  +++I C  CSP++  L+ +   +   R+L  P LC DYC  F   C  
Sbjct: 89  FDLKRHELCGDYIKDILCQECSPYAAHLYDAENTQTPLRNL--PGLCSDYCSAFHSNCHS 146

Query: 155 HIP------GFLQTTADE---FCFYYARKDGGLCFPDFPRKQVRGPASNYLDQMEEYDKV 205
            I       G  ++   +   FC      D   CFP+  R       ++YL++       
Sbjct: 147 AISLLTNDRGLQESHGRDGTRFCHLLDLPDKDYCFPNVLR-------NDYLNRHLG---- 195

Query: 206 EEISRKHKHNCF--CIQEVVSGLRQPVGALHSGDGSQRLFILEKEGYVKILTPEGEIFKE 263
             +  +    C   C+ EV +GLR PV  +H+GDG+ R F+ E+ G V +  P+G   ++
Sbjct: 196 --MVAQDPQGCLQLCLSEVANGLRNPVSMVHAGDGTHRFFVAEQVGVVWVYLPDGSRLEQ 253

Query: 264 PYLDIHKLVQSGIKGGDERGLLSLAFHPNYKKNGKLYVSYTTNQERWAIGPHDHILRVVE 323
           P+LD+  +V +    GDERG L LAFHP ++ N K Y+ Y+   ++         +R+ E
Sbjct: 254 PFLDLKNIVLTTPWIGDERGFLGLAFHPKFRHNRKFYIYYSCLDKKKV-----EKIRISE 308

Query: 324 YTVSRKNPHQVDLRTARVFLEVAELHRKHLGGQLLFGPDGFLYIILGDGMITLDD---ME 380
             VSR +P++ DL++ RV LE+ E    H GGQLLFG DG++YI  GDG    D      
Sbjct: 309 MKVSRADPNKADLKSERVILEIEEPASNHNGGQLLFGLDGYMYIFTGDGGQAGDPFGLFG 368

Query: 381 EMDGLSDFTGSVLRLDVD-TDMCNVPYSIPRSNPHFNSTNQPPEVFAHGLHDPGRCAVDR 439
                S   G VLR+DV+        Y +P  NP  +     P ++A+G+ +  RCAVDR
Sbjct: 369 NAQNKSSLLGKVLRIDVNRAGSHGKRYRVPSDNPFVSEPGAHPAIYAYGIRNMWRCAVDR 428

Query: 440 -HPTDININLTILCSDSNGKNRSSARILQIIKGKDY------------------ESEPSL 480
             P        I C D  G+NR    +  I+KG +Y                   S   +
Sbjct: 429 GDPITRQGRGRIFCGDV-GQNRFE-EVDLILKGGNYGWRAKEGFACYDKKLCHNASLDDV 486

Query: 481 LEFKPFSNG---PLVGGFVYRGCQSERLYGSYVFGD-RNGNFLTLQQSPVTKQWQEKPLC 536
           L    + +     + GG+VYRGC+S  L G Y+FGD  +G  + LQ+    K+W+++ LC
Sbjct: 487 LPIYAYGHAVGKSVTGGYVYRGCESPNLNGLYIFGDFMSGRLMALQEDRKNKKWKKQDLC 546

Query: 537 LGTSGSCR--GYFSGH---ILGFGEDELGEVYILSSSKSMTQTHNGKLYKIVDPKRPLMP 591
           LG++ SC   G  S H   I+ F EDE GE+Y L++S        G +YK VDP R   P
Sbjct: 547 LGSTTSCAFPGLISTHSKFIISFAEDEAGELYFLATSYPSAYAPRGSIYKFVDPSRRAPP 606

Query: 592 EECRATVQPAQT 603
            +C+    P +T
Sbjct: 607 GKCKYKPVPVRT 618


>gi|187936955 HHIP-like protein 1 isoform a [Homo sapiens]
          Length = 782

 Score =  257 bits (656), Expect = 3e-68
 Identities = 182/576 (31%), Positives = 272/576 (47%), Gaps = 73/576 (12%)

Query: 73  YPRLSCCLRSDSPGLGRLENKIFSVTNNTE---CGKLLEEIKCALCSPHSQSLFHSPERE 129
           Y    CC       L R    + S  +  E   C     ++ C  CSP++  L+ + +  
Sbjct: 42  YSDFGCCDEGRDAELTRRFWALASRVDAAEWAACAGYARDLLCQECSPYAAHLYDAEDPF 101

Query: 130 VLERDLVLPLLCKDYCKEFFYTCRG---HIPGFLQTTADE-----FCFYYARKDGGLCFP 181
              R   +P LC+DYC + ++ CRG   H+    +  A E     FC Y +  D   CFP
Sbjct: 102 TPLR--TVPGLCQDYCLDMWHKCRGLFRHLSTDQELWALEGNLARFCRYLSLDDTDYCFP 159

Query: 182 DFPRKQVRGPASNYLDQMEEYDKVEEISRKHKHNCF--CIQEVVSGLRQPVGALHSGDGS 239
                 V    ++ L  +    K           C   C++EV +GLR PV  +H+ DG+
Sbjct: 160 YL---LVNKNLNSNLGHVVADAK----------GCLQLCLEEVANGLRNPVAMVHARDGT 206

Query: 240 QRLFILEKEGYVKILTPEGEIFKEPYLDIHKLVQSGIKGGDERGLLSLAFHPNYKKNGKL 299
            R F+ E+ G V    P+     +P+L+I ++V +    GDERG L +AFHP+++ N +L
Sbjct: 207 HRFFVAEQVGLVWAYLPDRSRLGKPFLNISRVVLTSPWEGDERGFLGIAFHPSFQHNRRL 266

Query: 300 YVSYTT--NQERWAIGPHDHILRVVEYTVSRKNPHQVDLRTARVFLEVAELHRKHLGGQL 357
           YV Y+       W        +R+ E+ VS  + + VD  + R+ LEV E    H GGQL
Sbjct: 267 YVYYSVGIRSSEW--------IRISEFRVSEDDENAVDHSSERIILEVKEPASNHNGGQL 318

Query: 358 LFGPDGFLYIILGDGMITLD---DMEEMDGLSDFTGSVLRLDVDTDMCNVPYSIPRSNPH 414
           LFG DG+LYI  GDG +  D           S   G VLR+DVD     +PY IP  NP 
Sbjct: 319 LFGDDGYLYIFTGDGGMAGDPFGTFGNAQNKSALLGKVLRIDVDRKERGLPYGIPPDNPF 378

Query: 415 FNSTNQPPEVFAHGLHDPGRCAVDR-HPTDININLTILCSDSNGKNRSSARILQIIKGKD 473
                  PEV+A G+ +  RC+ DR  P+       + C D  G+N+    +  + +G +
Sbjct: 379 VGDPAAQPEVYALGVRNMWRCSFDRGDPSSGTGRGRLFCGDV-GQNKFE-EVDVVERGGN 436

Query: 474 YE---------------SEPSLLEFKPFSNGP------LVGGFVYRGCQSERLYGSYVFG 512
           Y                +  SL +  P    P      + GG+VYRGC+   L G Y+FG
Sbjct: 437 YGWRAREGFECYDRSLCANTSLNDLLPIFAYPHTVGKSVTGGYVYRGCEYPNLNGLYIFG 496

Query: 513 D-RNGNFLTLQQSPVTKQWQEKPLCLGTSGSCR-----GYFSGHILGFGEDELGEVYILS 566
           D  +G  ++LQ++P T QWQ   +C+G   +C        +  +I+ FGEDE GE+Y +S
Sbjct: 497 DFMSGRLMSLQENPGTGQWQYSEICMGHGQTCEFPGLINNYYPYIISFGEDEAGELYFMS 556

Query: 567 SSKSMTQTHNGKLYKIVDPKRPLMPEECRATVQPAQ 602
           + +       G +YKI+D  R   P +C+  +QPAQ
Sbjct: 557 TGEPSATAPRGVVYKIIDASRRAPPGKCQ--IQPAQ 590


>gi|187936953 HHIP-like protein 1 isoform b [Homo sapiens]
          Length = 608

 Score =  247 bits (630), Expect = 3e-65
 Identities = 175/558 (31%), Positives = 262/558 (46%), Gaps = 71/558 (12%)

Query: 73  YPRLSCCLRSDSPGLGRLENKIFSVTNNTE---CGKLLEEIKCALCSPHSQSLFHSPERE 129
           Y    CC       L R    + S  +  E   C     ++ C  CSP++  L+ + +  
Sbjct: 42  YSDFGCCDEGRDAELTRRFWALASRVDAAEWAACAGYARDLLCQECSPYAAHLYDAEDPF 101

Query: 130 VLERDLVLPLLCKDYCKEFFYTCRG---HIPGFLQTTADE-----FCFYYARKDGGLCFP 181
              R   +P LC+DYC + ++ CRG   H+    +  A E     FC Y +  D   CFP
Sbjct: 102 TPLR--TVPGLCQDYCLDMWHKCRGLFRHLSTDQELWALEGNLARFCRYLSLDDTDYCFP 159

Query: 182 DFPRKQVRGPASNYLDQMEEYDKVEEISRKHKHNCF--CIQEVVSGLRQPVGALHSGDGS 239
                 V    ++ L  +    K           C   C++EV +GLR PV  +H+ DG+
Sbjct: 160 YL---LVNKNLNSNLGHVVADAK----------GCLQLCLEEVANGLRNPVAMVHARDGT 206

Query: 240 QRLFILEKEGYVKILTPEGEIFKEPYLDIHKLVQSGIKGGDERGLLSLAFHPNYKKNGKL 299
            R F+ E+ G V    P+     +P+L+I ++V +    GDERG L +AFHP+++ N +L
Sbjct: 207 HRFFVAEQVGLVWAYLPDRSRLGKPFLNISRVVLTSPWEGDERGFLGIAFHPSFQHNRRL 266

Query: 300 YVSYTT--NQERWAIGPHDHILRVVEYTVSRKNPHQVDLRTARVFLEVAELHRKHLGGQL 357
           YV Y+       W        +R+ E+ VS  + + VD  + R+ LEV E    H GGQL
Sbjct: 267 YVYYSVGIRSSEW--------IRISEFRVSEDDENAVDHSSERIILEVKEPASNHNGGQL 318

Query: 358 LFGPDGFLYIILGDGMITLD---DMEEMDGLSDFTGSVLRLDVDTDMCNVPYSIPRSNPH 414
           LFG DG+LYI  GDG +  D           S   G VLR+DVD     +PY IP  NP 
Sbjct: 319 LFGDDGYLYIFTGDGGMAGDPFGTFGNAQNKSALLGKVLRIDVDRKERGLPYGIPPDNPF 378

Query: 415 FNSTNQPPEVFAHGLHDPGRCAVDR-HPTDININLTILCSDSNGKNRSSARILQIIKGKD 473
                  PEV+A G+ +  RC+ DR  P+       + C D  G+N+    +  + +G +
Sbjct: 379 VGDPAAQPEVYALGVRNMWRCSFDRGDPSSGTGRGRLFCGDV-GQNKFE-EVDVVERGGN 436

Query: 474 YE---------------SEPSLLEFKPFSNGP------LVGGFVYRGCQSERLYGSYVFG 512
           Y                +  SL +  P    P      + GG+VYRGC+   L G Y+FG
Sbjct: 437 YGWRAREGFECYDRSLCANTSLNDLLPIFAYPHTVGKSVTGGYVYRGCEYPNLNGLYIFG 496

Query: 513 D-RNGNFLTLQQSPVTKQWQEKPLCLGTSGSCR-----GYFSGHILGFGEDELGEVYILS 566
           D  +G  ++LQ++P T QWQ   +C+G   +C        +  +I+ FGEDE GE+Y +S
Sbjct: 497 DFMSGRLMSLQENPGTGQWQYSEICMGHGQTCEFPGLINNYYPYIISFGEDEAGELYFMS 556

Query: 567 SSKSMTQTHNGKLYKIVD 584
           + +       G +YKI+D
Sbjct: 557 TGEPSATAPRGVVYKIID 574


>gi|209571555 von Willebrand factor D and EGF domains [Homo sapiens]
          Length = 1590

 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 30/64 (46%), Positives = 36/64 (56%), Gaps = 1/64 (1%)

Query: 605  TSECSRLCRNG-YCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKGYLG 663
            T  C+R C NG  C     C C PGW G  C TA C+P C +GG C +PN CLC  G+ G
Sbjct: 1391 TMVCNRHCENGGQCLTPDICQCKPGWYGPTCSTALCDPVCLNGGSCNKPNTCLCPNGFFG 1450

Query: 664  PQCE 667
              C+
Sbjct: 1451 EHCQ 1454



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 28/76 (36%), Positives = 38/76 (50%), Gaps = 1/76 (1%)

Query: 593  ECRATVQPAQTLTSECSRLCRN-GYCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVR 651
            +C+     +   T+ C   C+N G C     C C PG  G  C    C P C+HGG C+ 
Sbjct: 1315 KCKPGYIGSNCQTALCDPDCKNHGKCIKPNICQCLPGHGGATCDEEHCNPPCQHGGTCLA 1374

Query: 652  PNKCLCKKGYLGPQCE 667
             N C C  G++GP+CE
Sbjct: 1375 GNLCTCPYGFVGPRCE 1390



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 25/60 (41%), Positives = 36/60 (60%), Gaps = 1/60 (1%)

Query: 605  TSECSRLCRNG-YCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKGYLG 663
            T+ C  +C NG  C     C C  G+ G+ C+ A C P C++GG C+R N C+C++GY G
Sbjct: 1423 TALCDPVCLNGGSCNKPNTCLCPNGFFGEHCQNAFCHPPCKNGGHCMRNNVCVCREGYTG 1482



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 26/65 (40%), Positives = 34/65 (52%), Gaps = 1/65 (1%)

Query: 605  TSECSRLCRNG-YCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKGYLG 663
            T  C + C+NG  C     C C   WEG  C+   C P C +GG C+ PN C C+  Y G
Sbjct: 1519 TPICLQKCKNGGECIAPSICHCPSSWEGVRCQIPICNPKCLYGGRCIFPNVCSCRTEYSG 1578

Query: 664  PQCEQ 668
             +CE+
Sbjct: 1579 VKCEK 1583



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 21/52 (40%), Positives = 31/52 (59%)

Query: 617  CTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQCEQ 668
            C     C C PG+ G  C+TA C+P C++ G C++PN C C  G+ G  C++
Sbjct: 1308 CVAPNICKCKPGYIGSNCQTALCDPDCKNHGKCIKPNICQCLPGHGGATCDE 1359



 Score = 56.6 bits (135), Expect = 8e-08
 Identities = 25/75 (33%), Positives = 33/75 (44%), Gaps = 1/75 (1%)

Query: 594  CRATVQPAQTLTSECSRLCRNG-YCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRP 652
            CR      +   S C   C NG  C     C C  GW G  C T  C   C++GG C+ P
Sbjct: 1476 CREGYTGRRFQKSICDPTCMNGGKCVGPSTCSCPSGWSGKRCNTPICLQKCKNGGECIAP 1535

Query: 653  NKCLCKKGYLGPQCE 667
            + C C   + G +C+
Sbjct: 1536 SICHCPSSWEGVRCQ 1550



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 22/60 (36%), Positives = 32/60 (53%), Gaps = 1/60 (1%)

Query: 608  CSRLCRNG-YCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQC 666
            C   C+NG +C     C C  G+ G   + + C+P C +GG CV P+ C C  G+ G +C
Sbjct: 1458 CHPPCKNGGHCMRNNVCVCREGYTGRRFQKSICDPTCMNGGKCVGPSTCSCPSGWSGKRC 1517



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 23/60 (38%), Positives = 31/60 (51%), Gaps = 1/60 (1%)

Query: 608  CSRLCRNG-YCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQC 666
            C+  C++G  C     C C  G+ G  C T  C   C +GG C+ P+ C CK G+ GP C
Sbjct: 1362 CNPPCQHGGTCLAGNLCTCPYGFVGPRCETMVCNRHCENGGQCLTPDICQCKPGWYGPTC 1421



 Score = 35.8 bits (81), Expect = 0.14
 Identities = 13/29 (44%), Positives = 16/29 (55%)

Query: 639  CEPACRHGGVCVRPNKCLCKKGYLGPQCE 667
            C+  C     CV PN C CK GY+G  C+
Sbjct: 1298 CKYPCGKSRECVAPNICKCKPGYIGSNCQ 1326


>gi|111125011 WNT inhibitory factor 1 precursor [Homo sapiens]
          Length = 379

 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 30/64 (46%), Positives = 37/64 (57%), Gaps = 1/64 (1%)

Query: 606 SECSRLCRNG-YCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKGYLGP 664
           + CS  C NG  C   GKC C PG EG+ C  +KC   CR+GG C+  +KC C KGY G 
Sbjct: 244 ANCSTTCFNGGTCFYPGKCICPPGLEGEQCEISKCPQPCRNGGKCIGKSKCKCSKGYQGD 303

Query: 665 QCEQ 668
            C +
Sbjct: 304 LCSK 307



 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 31/76 (40%), Positives = 41/76 (53%), Gaps = 1/76 (1%)

Query: 594 CRATVQPAQTLTSECSRLCRNG-YCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRP 652
           C   ++  Q   S+C + CRNG  C    KC CS G++GD C    CEP C   G C  P
Sbjct: 264 CPPGLEGEQCEISKCPQPCRNGGKCIGKSKCKCSKGYQGDLCSKPVCEPGCGAHGTCHEP 323

Query: 653 NKCLCKKGYLGPQCEQ 668
           NKC C++G+ G  C +
Sbjct: 324 NKCQCQEGWHGRHCNK 339



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 26/66 (39%), Positives = 36/66 (54%), Gaps = 1/66 (1%)

Query: 606 SECSRLCRNG-YCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKGYLGP 664
           +EC   CRNG +C     C C  G+ G  C  A C P C +GG+CV P  C+C  G+ G 
Sbjct: 180 AECPGGCRNGGFCNERRICECPDGFHGPHCEKALCTPRCMNGGLCVTPGFCICPPGFYGV 239

Query: 665 QCEQVD 670
            C++ +
Sbjct: 240 NCDKAN 245



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 27/61 (44%), Positives = 31/61 (50%), Gaps = 1/61 (1%)

Query: 608 CSRLCRNG-YCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQC 666
           C+  C NG  C   G C C PG+ G  C  A C   C +GG C  P KC+C  G  G QC
Sbjct: 214 CTPRCMNGGLCVTPGFCICPPGFYGVNCDKANCSTTCFNGGTCFYPGKCICPPGLEGEQC 273

Query: 667 E 667
           E
Sbjct: 274 E 274



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 15/35 (42%), Positives = 20/35 (57%)

Query: 634 CRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQCEQ 668
           C+ A+C   CR+GG C     C C  G+ GP CE+
Sbjct: 177 CQQAECPGGCRNGGFCNERRICECPDGFHGPHCEK 211


>gi|66346695 fibrillin 2 precursor [Homo sapiens]
          Length = 2912

 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 26/62 (41%), Positives = 35/62 (56%)

Query: 607 ECSRLCRNGYCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQC 666
           +CS  C NG       C C  G+ G +C    CE  C++GG C+ PN+C C  G+ GPQC
Sbjct: 148 QCSVRCMNGGTCADDHCQCQKGYIGTYCGQPVCENGCQNGGRCIGPNRCACVYGFTGPQC 207

Query: 667 EQ 668
           E+
Sbjct: 208 ER 209



 Score = 37.7 bits (86), Expect = 0.036
 Identities = 17/46 (36%), Positives = 21/46 (45%), Gaps = 5/46 (10%)

Query: 625 CSPGWE----GDFCRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQC 666
           C PGW+    G+ C    C  +C  G  C RPN C C  G +   C
Sbjct: 97  CCPGWKTLPGGNQCIVPICRNSCGDG-FCSRPNMCTCSSGQISSTC 141



 Score = 30.4 bits (67), Expect = 5.8
 Identities = 24/69 (34%), Positives = 29/69 (42%), Gaps = 14/69 (20%)

Query: 607  ECSRL-CRNGYCTPTG---KCCCSPGWE----GDFCRTAKCEP----ACRHGGVC--VRP 652
            EC R  C NG C  T     C C PG+E     D     +C       CR+G     +  
Sbjct: 1937 ECERHPCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGS 1996

Query: 653  NKCLCKKGY 661
             KCLC +GY
Sbjct: 1997 FKCLCNEGY 2005



 Score = 29.6 bits (65), Expect = 9.9
 Identities = 23/84 (27%), Positives = 35/84 (41%), Gaps = 10/84 (11%)

Query: 609 SRLCRNGYCTPT---GKCCCSPGWE----GDFCRTAKC-EPACRHGGVCVRPNK--CLCK 658
           + LC NG C PT    +C C+ G++    GD     +C    C +G     P    C C 
Sbjct: 502 ANLCLNGRCIPTVSSYRCECNMGYKQDANGDCIDVDECTSNPCTNGDCVNTPGSYYCKCH 561

Query: 659 KGYLGPQCEQVDRNIRRVTRAGIL 682
            G+     +Q   +I    + G+L
Sbjct: 562 AGFQRTPTKQACIDIDECIQNGVL 585


>gi|56237021 fibrillin 3 precursor [Homo sapiens]
          Length = 2809

 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 26/63 (41%), Positives = 34/63 (53%)

Query: 606 SECSRLCRNGYCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQ 665
           S CS  C NG       C C  G+ G  C    C+  C +GG C+ PN+C C  G++GPQ
Sbjct: 118 SGCSVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQ 177

Query: 666 CEQ 668
           CE+
Sbjct: 178 CER 180



 Score = 38.5 bits (88), Expect = 0.021
 Identities = 18/45 (40%), Positives = 20/45 (44%), Gaps = 3/45 (6%)

Query: 625 CSPGWEGDFCRTAKCEPACRHG---GVCVRPNKCLCKKGYLGPQC 666
           C PGW     R+    P CR     G C +PN C C  G L P C
Sbjct: 68  CCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSC 112



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 24/78 (30%), Positives = 30/78 (38%), Gaps = 18/78 (23%)

Query: 611  LCRNGYCTPTG---KCCCSPGWEGDFCRTAKC--------EPACRHGGVCVRPN---KCL 656
            LC  G C  T    +C C PG+E  F     C        +P    GG C   +   KC 
Sbjct: 1038 LCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQ 1097

Query: 657  CKKGY----LGPQCEQVD 670
            C  G+     G  CE +D
Sbjct: 1098 CPPGHELTAKGTACEDID 1115



 Score = 30.4 bits (67), Expect = 5.8
 Identities = 21/76 (27%), Positives = 31/76 (40%), Gaps = 10/76 (13%)

Query: 596 ATVQPAQTLTSECSRLCRNGYCTPTG---KCCCSPGW----EGDFCRTAKCEPACRHGGV 648
           AT+     +    + LC NG C PT    +C C+ G+     G+     +C  +  H G 
Sbjct: 403 ATLNQTIDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGD 462

Query: 649 CVR---PNKCLCKKGY 661
           CV       C C  G+
Sbjct: 463 CVNIPGTYHCRCYPGF 478


>gi|148886654 polydom [Homo sapiens]
          Length = 3571

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 28/65 (43%), Positives = 34/65 (52%), Gaps = 1/65 (1%)

Query: 608  CSRLCRNG-YCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQC 666
            C   C NG  C    +C C PGW G  C TA C+  C +GG CVRPN+C C   + G  C
Sbjct: 3504 CILPCLNGGRCVAPYQCDCPPGWTGSRCHTAVCQSPCLNGGKCVRPNRCHCLSSWTGHNC 3563

Query: 667  EQVDR 671
             +  R
Sbjct: 3564 SRKRR 3568



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 23/60 (38%), Positives = 28/60 (46%), Gaps = 1/60 (1%)

Query: 608  CSRLCRNG-YCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQC 666
            C   C+NG  C     C C  GW G  C    C   C +GG CV P +C C  G+ G +C
Sbjct: 3472 CRFPCQNGGICQRPNACSCPEGWMGRLCEEPICILPCLNGGRCVAPYQCDCPPGWTGSRC 3531



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 17/35 (48%), Positives = 24/35 (68%), Gaps = 1/35 (2%)

Query: 634  CRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQCEQ 668
            CR A C   C++GG+C RPN C C +G++G  CE+
Sbjct: 3468 CR-AVCRFPCQNGGICQRPNACSCPEGWMGRLCEE 3501



 Score = 37.4 bits (85), Expect = 0.048
 Identities = 25/67 (37%), Positives = 31/67 (46%), Gaps = 10/67 (14%)

Query: 612  CRN-GYCTPTGK---CCCSPGWEGDFCRTA--KCEPA-CRHGGVC---VRPNKCLCKKGY 661
            C N G C   G+   C C  G+ G  C T   +C P  C + GVC   V    C C  GY
Sbjct: 1202 CHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGY 1261

Query: 662  LGPQCEQ 668
             G +CE+
Sbjct: 1262 TGQRCEE 1268



 Score = 37.4 bits (85), Expect = 0.048
 Identities = 23/72 (31%), Positives = 34/72 (47%), Gaps = 11/72 (15%)

Query: 607  EC-SRLCRNGYCTPTG----KCCCSPGWEGDFCRTA--KCEP-ACRHGGVCV---RPNKC 655
            EC S+ C+NG     G    +C C+ G+ G  C     +C+   CR+   CV       C
Sbjct: 1348 ECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSC 1407

Query: 656  LCKKGYLGPQCE 667
             C+ G+ G +CE
Sbjct: 1408 KCQPGFSGKRCE 1419



 Score = 35.0 bits (79), Expect = 0.24
 Identities = 26/77 (33%), Positives = 36/77 (46%), Gaps = 11/77 (14%)

Query: 602  QTLTSECSRL--CRNGYCTP-TGK--CCCSPGWEGDFCRTA--KCEPA-CRHGGVCV--- 650
            +T   ECS L    NG C    G+  C C  G+ G  C     +C  + C + G+CV   
Sbjct: 1229 ETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGQRCEENINECSSSPCLNKGICVDGV 1288

Query: 651  RPNKCLCKKGYLGPQCE 667
               +C C KG++G  CE
Sbjct: 1289 AGYRCTCVKGFVGLHCE 1305



 Score = 33.5 bits (75), Expect = 0.69
 Identities = 17/51 (33%), Positives = 23/51 (45%), Gaps = 6/51 (11%)

Query: 623  CCCSPGWEGDFC--RTAKC-EPACRHGGVC---VRPNKCLCKKGYLGPQCE 667
            C C PG+ G  C     +C    C++G  C       +CLC  G+ G  CE
Sbjct: 1331 CKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCE 1381


>gi|24430141 fibrillin 1 precursor [Homo sapiens]
          Length = 2871

 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 26/61 (42%), Positives = 32/61 (52%)

Query: 608 CSRLCRNGYCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQCE 667
           C+  C NG       C C  G+ G  C    CE  C +GG CV PN+C C  G+ GPQCE
Sbjct: 119 CNIRCMNGGSCSDDHCLCQKGYIGTHCGQPVCESGCLNGGRCVAPNRCACTYGFTGPQCE 178

Query: 668 Q 668
           +
Sbjct: 179 R 179



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 20/49 (40%), Positives = 23/49 (46%), Gaps = 11/49 (22%)

Query: 625 CSPGWE----GDFCRTAKCEPACRHG---GVCVRPNKCLCKKGYLGPQC 666
           C PGW+    G+ C      P CRH    G C RPN C C  G + P C
Sbjct: 67  CCPGWKTLPGGNQCIV----PICRHSCGDGFCSRPNMCTCPSGQIAPSC 111



 Score = 38.1 bits (87), Expect = 0.028
 Identities = 20/63 (31%), Positives = 28/63 (44%), Gaps = 12/63 (19%)

Query: 613  RNGYCTPTG---KCCCSPGWEGDFCRTAKCEPACRHGGVC---------VRPNKCLCKKG 660
            ++  CT T    KC CSPGW GD  +    +       +C         +   +CLCK+G
Sbjct: 1335 KHAVCTNTAGSFKCSCSPGWIGDGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEG 1394

Query: 661  YLG 663
            Y G
Sbjct: 1395 YTG 1397



 Score = 35.4 bits (80), Expect = 0.18
 Identities = 22/74 (29%), Positives = 33/74 (44%), Gaps = 14/74 (18%)

Query: 611 LCRNGYCTPTG---KCCCSPGWE----GDFCRTAKCEPACRHGGVCVRPN---KCLCKKG 660
           LC+NG C PT    +C C+ G++    G+     +CE     GG C+       C C+ G
Sbjct: 459 LCQNGRCIPTPGSCRCECNKGFQLDLRGECIDVDECEKNPCAGGECINNQGSYTCQCRAG 518

Query: 661 YLG----PQCEQVD 670
           Y       +C  +D
Sbjct: 519 YQSTLTRTECRDID 532


>gi|222352166 nel-like 1 isoform 2 precursor [Homo sapiens]
          Length = 763

 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 29/60 (48%), Positives = 36/60 (60%), Gaps = 6/60 (10%)

Query: 614 NGYCTPTGK---CCCSPGWEGD--FCRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQCEQ 668
           N  CT T +   C C PG+ G+   CR A CE  CR+GG CV PNKC+C  G+ G  CE+
Sbjct: 490 NAICTNTVQGHSCTCKPGYVGNGTICR-AFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEK 548



 Score = 30.0 bits (66), Expect = 7.6
 Identities = 21/68 (30%), Positives = 24/68 (35%), Gaps = 12/68 (17%)

Query: 608 CSRLCR-NGYCTPTGKCCCSPGWEGDFCRTAKCEPA-----CRHGGVCVR---PNKCLCK 658
           C   CR  G C    KC C  G+ G  C     E A     C +   C+       CLC 
Sbjct: 519 CEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECALRTHTCWNDSACINLAGGFDCLCP 578

Query: 659 KGYLGPQC 666
               GP C
Sbjct: 579 S---GPSC 583


>gi|222352164 nel-like 1 isoform 1 precursor [Homo sapiens]
          Length = 810

 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 29/60 (48%), Positives = 36/60 (60%), Gaps = 6/60 (10%)

Query: 614 NGYCTPTGK---CCCSPGWEGD--FCRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQCEQ 668
           N  CT T +   C C PG+ G+   CR A CE  CR+GG CV PNKC+C  G+ G  CE+
Sbjct: 490 NAICTNTVQGHSCTCKPGYVGNGTICR-AFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEK 548


>gi|74136023 delta-like 1 homolog [Homo sapiens]
          Length = 383

 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 29/79 (36%), Positives = 40/79 (50%), Gaps = 6/79 (7%)

Query: 603 TLTSECSRLC--RNGYCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKG 660
           T  +EC   C  +NG+C     C C PGW+G  C      P C H G+C  P +C+C  G
Sbjct: 21  TYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLH-GLCGEPGQCICTDG 79

Query: 661 YLGPQCEQVDRNIRRVTRA 679
           + G  C   DR++R  + A
Sbjct: 80  WDGELC---DRDVRACSSA 95



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 30/108 (27%), Positives = 48/108 (44%), Gaps = 11/108 (10%)

Query: 574 THNGKLYKIVDPKRPLMPEECRATVQPAQT--LTSEC--SRLCRNGYCTPTGKCCCSPGW 629
           T+  + +   +P+     ++     QP     L  +C  S  C +G C   G+C C+ GW
Sbjct: 21  TYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGW 80

Query: 630 EGDFCR--TAKCEPA-CRHGGVCVRPN----KCLCKKGYLGPQCEQVD 670
           +G+ C      C  A C + G CV  +    +C C  GY G  C++ D
Sbjct: 81  DGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKD 128



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 30/101 (29%), Positives = 38/101 (37%), Gaps = 23/101 (22%)

Query: 591 PEECRATVQPAQTLTSECSRLCRNGYCTPTG----------KCCCSPGWEGDFCRTAKCE 640
           P +C  T      L     R C +  C   G          +C C+PG+ G  C+  K  
Sbjct: 71  PGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQK-KDG 129

Query: 641 PA------CRHGGVCVRPN------KCLCKKGYLGPQCEQV 669
           P       C+HGG CV          CLC  G+ G  CE V
Sbjct: 130 PCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIV 170



 Score = 36.6 bits (83), Expect = 0.081
 Identities = 17/52 (32%), Positives = 24/52 (46%), Gaps = 6/52 (11%)

Query: 623 CCCSPGWEGDFCRTA--KCEP-ACRHGGVCVRPN---KCLCKKGYLGPQCEQ 668
           C C PG+ G+FC      C P  C + GVC       +C C  G++   C +
Sbjct: 156 CLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSR 207


>gi|45593147 EGF-like-domain, multiple 9 [Homo sapiens]
          Length = 383

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 33/93 (35%), Positives = 43/93 (46%), Gaps = 17/93 (18%)

Query: 590 MPEECR------------ATVQPAQTLTSECSRLC--RNGYCTPTGKCCCSPGWEGDFCR 635
           MP  CR            A  QP +    +CS  C   +G C P G C C PGWEG  C 
Sbjct: 1   MPSGCRCLHLVCLLCILGAPGQPVRA--DDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCE 58

Query: 636 TAKCEPACRHGGVCVRPNKCLCKKGYLGPQCEQ 668
                P C+H G C +P +C+C  G+ G  C++
Sbjct: 59  RCVRMPGCQH-GTCHQPWQCICHSGWAGKFCDK 90



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 22/71 (30%), Positives = 33/71 (46%), Gaps = 10/71 (14%)

Query: 608 CSRL--CRNGYCTPTGKCCCSPGWEGDFC----RTAKCEPACRHGGVCVRPN----KCLC 657
           C R+  C++G C    +C C  GW G FC         +  C++GG C+        C+C
Sbjct: 60  CVRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVC 119

Query: 658 KKGYLGPQCEQ 668
             G+ G  CE+
Sbjct: 120 LPGFHGRDCER 130



 Score = 37.7 bits (86), Expect = 0.036
 Identities = 25/72 (34%), Positives = 32/72 (44%), Gaps = 16/72 (22%)

Query: 612 CRNG-YCTPTG----KCCCSPGWEGDFC--RTAKCEPA---CRHGGVCVRPN------KC 655
           C+NG  C   G     C C PG+ G  C  +   CE A   CR+GG C           C
Sbjct: 101 CQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTC 160

Query: 656 LCKKGYLGPQCE 667
            C  G++G +CE
Sbjct: 161 RCLVGFVGARCE 172



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 25/70 (35%), Positives = 28/70 (40%), Gaps = 10/70 (14%)

Query: 610 RLCRNGYCTPTG----KCCCSPGWEGDFCRTAKCEPA---CRHGGVC---VRPNKCLCKK 659
           R C NG     G     C C  G+ G FC     + A   C+ G  C   V    CLC  
Sbjct: 181 RPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPS 240

Query: 660 GYLGPQCEQV 669
           GY G  CE V
Sbjct: 241 GYGGKTCELV 250


>gi|45545431 EGF-like-domain, multiple 9 [Homo sapiens]
          Length = 383

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 33/93 (35%), Positives = 43/93 (46%), Gaps = 17/93 (18%)

Query: 590 MPEECR------------ATVQPAQTLTSECSRLC--RNGYCTPTGKCCCSPGWEGDFCR 635
           MP  CR            A  QP +    +CS  C   +G C P G C C PGWEG  C 
Sbjct: 1   MPSGCRCLHLVCLLCILGAPGQPVRA--DDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCE 58

Query: 636 TAKCEPACRHGGVCVRPNKCLCKKGYLGPQCEQ 668
                P C+H G C +P +C+C  G+ G  C++
Sbjct: 59  RCVRMPGCQH-GTCHQPWQCICHSGWAGKFCDK 90



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 22/71 (30%), Positives = 33/71 (46%), Gaps = 10/71 (14%)

Query: 608 CSRL--CRNGYCTPTGKCCCSPGWEGDFC----RTAKCEPACRHGGVCVRPN----KCLC 657
           C R+  C++G C    +C C  GW G FC         +  C++GG C+        C+C
Sbjct: 60  CVRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVC 119

Query: 658 KKGYLGPQCEQ 668
             G+ G  CE+
Sbjct: 120 LPGFHGRDCER 130



 Score = 37.7 bits (86), Expect = 0.036
 Identities = 25/72 (34%), Positives = 32/72 (44%), Gaps = 16/72 (22%)

Query: 612 CRNG-YCTPTG----KCCCSPGWEGDFC--RTAKCEPA---CRHGGVCVRPN------KC 655
           C+NG  C   G     C C PG+ G  C  +   CE A   CR+GG C           C
Sbjct: 101 CQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTC 160

Query: 656 LCKKGYLGPQCE 667
            C  G++G +CE
Sbjct: 161 RCLVGFVGARCE 172



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 25/70 (35%), Positives = 28/70 (40%), Gaps = 10/70 (14%)

Query: 610 RLCRNGYCTPTG----KCCCSPGWEGDFCRTAKCEPA---CRHGGVC---VRPNKCLCKK 659
           R C NG     G     C C  G+ G FC     + A   C+ G  C   V    CLC  
Sbjct: 181 RPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPS 240

Query: 660 GYLGPQCEQV 669
           GY G  CE V
Sbjct: 241 GYGGKTCELV 250


>gi|9506545 delta-like 4 protein precursor [Homo sapiens]
          Length = 685

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 27/69 (39%), Positives = 36/69 (52%), Gaps = 8/69 (11%)

Query: 608 CSRLC--RNGY-----CTPTGKCCCSPGWEGDFCRTAKCEPAC-RHGGVCVRPNKCLCKK 659
           CSRLC  RN +     C P G   C PGW G++C+   C   C    G C +P +CLC+ 
Sbjct: 184 CSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAECLCRP 243

Query: 660 GYLGPQCEQ 668
           G+ G  C +
Sbjct: 244 GWQGRLCNE 252



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 23/56 (41%), Positives = 31/56 (55%), Gaps = 1/56 (1%)

Query: 613 RNGYCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQCEQ 668
           +NGYC+   +C C PGW+G  C        CRH G C  P +C C +G+ G  C+Q
Sbjct: 229 QNGYCSKPAECLCRPGWQGRLCNECIPHNGCRH-GTCSTPWQCTCDEGWGGLFCDQ 283



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 28/87 (32%), Positives = 35/87 (40%), Gaps = 10/87 (11%)

Query: 591 PEECRATVQPAQTLTSEC--SRLCRNGYCTPTGKCCCSPGWEGDFC----RTAKCEPACR 644
           P EC         L +EC     CR+G C+   +C C  GW G FC            C+
Sbjct: 236 PAECLCRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCK 295

Query: 645 HGGVC----VRPNKCLCKKGYLGPQCE 667
           +G  C     R   C C+ GY G  CE
Sbjct: 296 NGATCSNSGQRSYTCTCRPGYTGVDCE 322



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 25/67 (37%), Positives = 34/67 (50%), Gaps = 11/67 (16%)

Query: 612 CRNGY-CTPTGK----CCCSPGWEGDFCRT--AKCEP-ACRHGGVCVRPNK---CLCKKG 660
           C+NG  C+ +G+    C C PG+ G  C    ++C+   CR+GG C        CLC  G
Sbjct: 294 CKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPG 353

Query: 661 YLGPQCE 667
           Y G  CE
Sbjct: 354 YYGLHCE 360



 Score = 39.3 bits (90), Expect = 0.013
 Identities = 24/69 (34%), Positives = 30/69 (43%), Gaps = 10/69 (14%)

Query: 609 SRLCRNG-YCT---PTGKCCCSPGWEGDFCRTAKCEPA---CRHGGVC---VRPNKCLCK 658
           S  C NG  C    P+  C C PG+ G +C     + A   C HGG C        C C 
Sbjct: 408 SNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCP 467

Query: 659 KGYLGPQCE 667
            G+ G +CE
Sbjct: 468 AGFSGRRCE 476


>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
          Length = 1541

 Score = 56.6 bits (135), Expect = 8e-08
 Identities = 31/87 (35%), Positives = 39/87 (44%), Gaps = 16/87 (18%)

Query: 598 VQPAQTLTSECSRLC---RNGYCTP-TGKCCCSPGWEGDFCRTA------------KCEP 641
           V PA      C   C    +G+C P TG C C+PGW G  C+ A             C  
Sbjct: 816 VCPAGWYGPSCQTRCSCANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNC 875

Query: 642 ACRHGGVCVRPNKCLCKKGYLGPQCEQ 668
           +  HG        CLC+ GY+GP+CEQ
Sbjct: 876 SAGHGSCDAISGLCLCEAGYVGPRCEQ 902



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 37/116 (31%), Positives = 50/116 (43%), Gaps = 22/116 (18%)

Query: 576  NGKLYKIVDPKRPLMPEECRATVQPAQTLTSECSRLCR--NGY-CTPT-GKCCCSPGWEG 631
            NG        + P   E C     PA T    CS+ C   NG  C P  G+C C+PGW G
Sbjct: 972  NGSCLCPAGRRGPRCAETC-----PAHTYGHNCSQACACFNGASCDPVHGQCHCAPGWMG 1026

Query: 632  DFCRTA--------KCEPA--CRHGGVC-VRPNKCLCKKGYLGPQCEQ--VDRNIR 674
              C  A         C  +  C++GG C      C C +G+ G  CE+  + R++R
Sbjct: 1027 PSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACEKECLPRDVR 1082



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 30/84 (35%), Positives = 38/84 (45%), Gaps = 17/84 (20%)

Query: 600  PAQTLTSEC--SRLCRNG-YCTP-TGKCCCSPGWEGDFCRTAKCEP-----ACRHGGVCV 650
            PA      C  S LC+NG  C P +G C C  GW G  C   +C P      CRH G C+
Sbjct: 1034 PAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACEK-ECLPRDVRAGCRHSGGCL 1092

Query: 651  -------RPNKCLCKKGYLGPQCE 667
                      +CLC  G+ G +C+
Sbjct: 1093 NGGLCDPHTGRCLCPAGWTGDKCQ 1116



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 28/86 (32%), Positives = 35/86 (40%), Gaps = 17/86 (19%)

Query: 600 PAQTLTSECSRLCRNGYCT---PTGKCCCSPGWEGDFCRTAKCE------------PACR 644
           P  T    CS  C  G       TG+C C PG  G+ C  A C             PAC+
Sbjct: 732 PVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCE-ADCPEGRWGLGCQEICPACQ 790

Query: 645 HGGVC-VRPNKCLCKKGYLGPQCEQV 669
           H   C      CLC  G++G +C+ V
Sbjct: 791 HAARCDPETGACLCLPGFVGSRCQDV 816



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 30/90 (33%), Positives = 37/90 (41%), Gaps = 16/90 (17%)

Query: 593  ECRATVQPAQTLTSECSRLCRNGY---CTP-TGKCCCSPGWEGDFCRT--------AKCE 640
            +C  T  P       C+ +C  G    C P TG C C PG  G  C            CE
Sbjct: 1244 DCNLTC-PQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCE 1302

Query: 641  P--ACRHGGVCVRPN-KCLCKKGYLGPQCE 667
               +CR+GG+C   N  C C  G+ G  CE
Sbjct: 1303 HTCSCRNGGLCHASNGSCSCGLGWTGRHCE 1332



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 22/60 (36%), Positives = 25/60 (41%), Gaps = 11/60 (18%)

Query: 620 TGKCCCSPGWEGDFCRTA--------KCEPACR--HGGVCVRPN-KCLCKKGYLGPQCEQ 668
           +G C C  GW G FC  A         C  AC    G  C   N  CLC  G  GP+C +
Sbjct: 929 SGACTCPAGWRGTFCEHACPAGFFGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAE 988



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 25/72 (34%), Positives = 31/72 (43%), Gaps = 17/72 (23%)

Query: 612  CRNG-YCTP-TGKCCCSPGWEGDFCRT------------AKCEPACRHGGVCVR-PNKCL 656
            C NG  C P TG+C C  GW GD C++             +C  +C  G  C      C 
Sbjct: 1091 CLNGGLCDPHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQRC--SCPPGAACHHVTGACR 1148

Query: 657  CKKGYLGPQCEQ 668
            C  G+ G  CEQ
Sbjct: 1149 CPPGFTGSGCEQ 1160



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 28/76 (36%), Positives = 33/76 (43%), Gaps = 17/76 (22%)

Query: 607  ECSRLCRNGY-CTP-TGKCCCSPGWEGDFCRTAKCEPA-----------CRHGGVCVR-P 652
            ECS  C N   C P TG C C PG+ G  C    C P            C+HG  C    
Sbjct: 1347 ECS--CHNNSTCEPATGTCRCGPGFYGQACEHP-CPPGFHGAGCQGLCWCQHGAPCDPIS 1403

Query: 653  NKCLCKKGYLGPQCEQ 668
             +CLC  G+ G  CE+
Sbjct: 1404 GRCLCPAGFHGHFCER 1419



 Score = 37.0 bits (84), Expect = 0.062
 Identities = 23/64 (35%), Positives = 28/64 (43%), Gaps = 12/64 (18%)

Query: 617  CTP-TGKCCCSPGWEGDFC----RTAKCEPACR-----HGGVCVRP--NKCLCKKGYLGP 664
            C P TG C C PG  G  C    R  +  P+C       GG    P   +C C  GY+GP
Sbjct: 1442 CDPVTGLCLCPPGRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYMGP 1501

Query: 665  QCEQ 668
             C +
Sbjct: 1502 TCRE 1505



 Score = 36.6 bits (83), Expect = 0.081
 Identities = 19/60 (31%), Positives = 24/60 (40%), Gaps = 13/60 (21%)

Query: 621 GKCCCSPGWEGDFCRTA----KCEPACRHGGVCVRPN---------KCLCKKGYLGPQCE 667
           G C C PG  G FC          P C     CV+P+          C CK G+ G +C+
Sbjct: 624 GACLCDPGLYGRFCHLTCPPWAFGPGCSEECQCVQPHTQSCDKRDGSCSCKAGFRGERCQ 683



 Score = 36.6 bits (83), Expect = 0.081
 Identities = 29/99 (29%), Positives = 33/99 (33%), Gaps = 31/99 (31%)

Query: 600  PAQTLTSECSRLCRNGY----------CTP-------TGKCCCSPGWEGDFCRTAKCEPA 642
            PA     +C   C  G+          C P       TG C C PG+ G  C  A C P 
Sbjct: 1107 PAGWTGDKCQSPCLRGWFGEACAQRCSCPPGAACHHVTGACRCPPGFTGSGCEQA-CPPG 1165

Query: 643  -----CRHGGVCVRPNK--------CLCKKGYLGPQCEQ 668
                 C     C   N         C C  GY GP C+Q
Sbjct: 1166 SFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQ 1204



 Score = 36.6 bits (83), Expect = 0.081
 Identities = 24/71 (33%), Positives = 26/71 (36%), Gaps = 17/71 (23%)

Query: 612  CRNG-YC-TPTGKCCCSPGWEGDFCRTAKCEPACRHGGVC-------------VRPNKCL 656
            CRNG  C    G C C  GW G  C  A C P  R+G  C                  C 
Sbjct: 1307 CRNGGLCHASNGSCSCGLGWTGRHCELA-CPPG-RYGAACHLECSCHNNSTCEPATGTCR 1364

Query: 657  CKKGYLGPQCE 667
            C  G+ G  CE
Sbjct: 1365 CGPGFYGQACE 1375



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 18/50 (36%), Positives = 26/50 (52%), Gaps = 7/50 (14%)

Query: 625 CSPGW----EGDFCRTAKCEPA-CRHGGVCV--RPNKCLCKKGYLGPQCE 667
           C  GW    + + C +A+C  + C HGG CV      C C  G+ GP+C+
Sbjct: 110 CCRGWMQQPDEEGCLSAECSASLCFHGGRCVPGSAQPCHCPPGFQGPRCQ 159



 Score = 35.8 bits (81), Expect = 0.14
 Identities = 24/75 (32%), Positives = 29/75 (38%), Gaps = 6/75 (8%)

Query: 593  ECRATVQPAQTLTSECSRLCRNGYCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVC-VR 651
            +C          T  CS  C  GY  P+ +  C PG  G  C    C   C +GG C   
Sbjct: 1176 QCPGENPACHPATGTCS--CAAGYHGPSCQQRCPPGRYGPGCEQL-C--GCLNGGSCDAA 1230

Query: 652  PNKCLCKKGYLGPQC 666
               C C  G+LG  C
Sbjct: 1231 TGACRCPTGFLGTDC 1245



 Score = 33.9 bits (76), Expect = 0.53
 Identities = 23/69 (33%), Positives = 28/69 (40%), Gaps = 15/69 (21%)

Query: 612  CRNGY-CTP-TGKCCCSPGWEGDFCRTAKCEPA-----------CRHGGVC-VRPNKCLC 657
            C++G  C P +G+C C  G+ G FC    CEP            C  G  C      CLC
Sbjct: 1393 CQHGAPCDPISGRCLCPAGFHGHFCERG-CEPGSFGEGCHQRCDCDGGAPCDPVTGLCLC 1451

Query: 658  KKGYLGPQC 666
              G  G  C
Sbjct: 1452 PPGRSGATC 1460



 Score = 33.1 bits (74), Expect = 0.90
 Identities = 20/75 (26%), Positives = 30/75 (40%), Gaps = 24/75 (32%)

Query: 600  PAQTLTSECSRLCR----NGYCTP-TGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNK 654
            P  +   +C+++C+    N  C P TG C C+ G+ G  C+                   
Sbjct: 1163 PPGSFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQR----------------- 1205

Query: 655  CLCKKGYLGPQCEQV 669
              C  G  GP CEQ+
Sbjct: 1206 --CPPGRYGPGCEQL 1218



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 27/84 (32%), Positives = 29/84 (34%), Gaps = 19/84 (22%)

Query: 600 PAQTLTSECSRLC---RNGYC-TPTGKCCCSPGWEGDFCRTA------------KCEPAC 643
           P  T    CS  C     G C + TG C C PG  G  C               KC   C
Sbjct: 556 PPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCEDGCPKGYYGKHCRKKCN--C 613

Query: 644 RHGGVCVR-PNKCLCKKGYLGPQC 666
            + G C R    CLC  G  G  C
Sbjct: 614 ANRGRCHRLYGACLCDPGLYGRFC 637



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 24/76 (31%), Positives = 29/76 (38%), Gaps = 15/76 (19%)

Query: 608  CSRLC---RNGYC-TPTGKCCCSPGWEGDFCRTA----KCEPACRH------GGVCVR-P 652
            C +LC     G C   TG C C  G+ G  C       +  P C H      G  C    
Sbjct: 1215 CEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGAACDPVT 1274

Query: 653  NKCLCKKGYLGPQCEQ 668
              CLC  G  G +CE+
Sbjct: 1275 GTCLCPPGRAGVRCER 1290



 Score = 32.0 bits (71), Expect = 2.0
 Identities = 28/81 (34%), Positives = 36/81 (44%), Gaps = 13/81 (16%)

Query: 594 CRATVQPAQT---LTSECSR-LC-RNGYCTPTGK--CCCSPGWEGDFCRTAKCEPACRHG 646
           CR  +Q       L++ECS  LC   G C P     C C PG++G  C+    E    +G
Sbjct: 111 CRGWMQQPDEEGCLSAECSASLCFHGGRCVPGSAQPCHCPPGFQGPRCQYDVDECRTHNG 170

Query: 647 GV---CVR-PNK--CLCKKGY 661
           G    CV  P    C CK G+
Sbjct: 171 GCQHRCVNTPGSYLCECKPGF 191


>gi|145701025 multiple EGF-like-domains 8 [Homo sapiens]
          Length = 2778

 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 25/64 (39%), Positives = 31/64 (48%), Gaps = 2/64 (3%)

Query: 606 SECSRLCRN-GYCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRP-NKCLCKKGYLG 663
           S C   C++ G C P G C C PGW G  C   +C   C   G C  P   C C+ G+LG
Sbjct: 140 SLCPGGCQSHGQCQPPGVCACEPGWGGPDCGLQECSAYCGSHGTCASPLGPCRCEPGFLG 199

Query: 664 PQCE 667
             C+
Sbjct: 200 RACD 203



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 19/50 (38%), Positives = 23/50 (46%), Gaps = 4/50 (8%)

Query: 621  GKCCCSPGWEGDFCRTAKCEPACR---HGGVCVRP-NKCLCKKGYLGPQC 666
            G C C  GW G  CR A C   C      G C +    C+C +G+ GP C
Sbjct: 1364 GLCRCPQGWAGPHCRMALCPENCNAHTGAGTCNQSLGVCICAEGFGGPDC 1413



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 25/73 (34%), Positives = 33/73 (45%), Gaps = 5/73 (6%)

Query: 613  RNGYCTPTG-KCCCSPGWEGDFCRTAKCEPACRHG---GVCVRPNKCLCKKGYLGPQCEQ 668
            +N +  P G +C C  G+  D   T  C P C  G   G CV P+ C C  G++G  C  
Sbjct: 2126 QNCHDQPHGYECSCKTGYTMDNM-TGLCRPVCAQGCVNGSCVEPDHCRCHFGFVGRNCST 2184

Query: 669  VDRNIRRVTRAGI 681
              R  R    AG+
Sbjct: 2185 ECRCNRHSECAGV 2197



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 21/62 (33%), Positives = 27/62 (43%), Gaps = 1/62 (1%)

Query: 608  CSRLCRNGYCTPTGKCCCSPGWEGDFCRT-AKCEPACRHGGVCVRPNKCLCKKGYLGPQC 666
            C++ C NG C     C C  G+ G  C T  +C       GV  R +  LC+    G  C
Sbjct: 2156 CAQGCVNGSCVEPDHCRCHFGFVGRNCSTECRCNRHSECAGVGARDHCLLCRNHTKGSHC 2215

Query: 667  EQ 668
            EQ
Sbjct: 2216 EQ 2217



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 14/39 (35%), Positives = 19/39 (48%), Gaps = 1/39 (2%)

Query: 628 GWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQC 666
           G+   F R + C   C+  G C  P  C C+ G+ GP C
Sbjct: 132 GFNASF-RFSLCPGGCQSHGQCQPPGVCACEPGWGGPDC 169


>gi|169790825 odz, odd Oz/ten-m homolog 4 [Homo sapiens]
          Length = 2769

 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 33/92 (35%), Positives = 45/92 (48%), Gaps = 11/92 (11%)

Query: 605 TSECSRL-CRNGYCTPTGKCCCSPGWEGDFCRTAKC-EPACRHGGVCVRPNKCLCKKGYL 662
           T++C  + C N     TG C C+PG++G+ C    C +P C   GVCVR  +C C  G+ 
Sbjct: 627 TNQCIDVACSNHGTCITGTCICNPGYKGESCEEVDCMDPTCSGRGVCVR-GECHCSVGWG 685

Query: 663 GPQCEQVDRNIRRVTRAGILDQIIDMTSYLLD 694
           G  CE          RA  LDQ     ++L D
Sbjct: 686 GTNCE--------TPRATCLDQCSGHGTFLPD 709



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 25/68 (36%), Positives = 34/68 (50%), Gaps = 4/68 (5%)

Query: 606 SECSRLCRNGYCTPTGKCCCSPGWEGDFC--RTAKC-EPACRHGGVCVRPNKCLCKKGYL 662
           + C  LC        G+C C  GW+G  C   T +C + AC + G C+    C+C  GY 
Sbjct: 595 ASCPVLCSGNGQYMKGRCLCHSGWKGAECDVPTNQCIDVACSNHGTCI-TGTCICNPGYK 653

Query: 663 GPQCEQVD 670
           G  CE+VD
Sbjct: 654 GESCEEVD 661



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 24/69 (34%), Positives = 30/69 (43%), Gaps = 3/69 (4%)

Query: 600 PAQTLTSECSRLCRNGYCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKK 659
           P  T   +CS      +   TG C C P W G  C    C   C   GVCV    C C+ 
Sbjct: 692 PRATCLDQCSG--HGTFLPDTGLCSCDPSWTGHDCSIEICAADCGGHGVCV-GGTCRCED 748

Query: 660 GYLGPQCEQ 668
           G++G  C+Q
Sbjct: 749 GWMGAACDQ 757



 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 24/67 (35%), Positives = 29/67 (43%), Gaps = 3/67 (4%)

Query: 614 NGYCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQCEQVDRNI 673
           +G C   G C C  GW G  C    C P C   G C R  KC C  G+ G  C  +   +
Sbjct: 736 HGVCVG-GTCRCEDGWMGAACDQRACHPRCAEHGTC-RDGKCECSPGWNGEHC-TIAHYL 792

Query: 674 RRVTRAG 680
            RV + G
Sbjct: 793 DRVVKEG 799



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 23/70 (32%), Positives = 30/70 (42%), Gaps = 13/70 (18%)

Query: 610 RLCRNGYCTPTGKCCCSPGWEGDFCRTAK---------CEPACRHGGVC---VRPNKCLC 657
           R   +G C   GKC CSPGW G+ C  A          C   C   G C   +    C+C
Sbjct: 763 RCAEHGTCRD-GKCECSPGWNGEHCTIAHYLDRVVKEGCPGLCNGNGRCTLDLNGWHCVC 821

Query: 658 KKGYLGPQCE 667
           + G+ G  C+
Sbjct: 822 QLGWRGAGCD 831



 Score = 38.5 bits (88), Expect = 0.021
 Identities = 19/54 (35%), Positives = 27/54 (50%), Gaps = 2/54 (3%)

Query: 614 NGYCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQCE 667
           NG C  +G C C  G+ G  C  A C   C   G  ++  +CLC  G+ G +C+
Sbjct: 573 NGDCI-SGTCHCFLGFLGPDCGRASCPVLCSGNGQYMK-GRCLCHSGWKGAECD 624



 Score = 31.6 bits (70), Expect = 2.6
 Identities = 26/87 (29%), Positives = 34/87 (39%), Gaps = 13/87 (14%)

Query: 592 EECRATVQPAQTLTSECSRLCR-NGYCTPT---GKCCCSPGWEGDFCRTAKCEPACRHG- 646
           E C       + +   C  LC  NG CT       C C  GW G  C T+  E AC    
Sbjct: 784 EHCTIAHYLDRVVKEGCPGLCNGNGRCTLDLNGWHCVCQLGWRGAGCDTS-METACGDSK 842

Query: 647 -----GV--CVRPNKCLCKKGYLGPQC 666
                G+  C+ P+ CL    ++ P C
Sbjct: 843 DNDGDGLVDCMDPDCCLQPLCHINPLC 869


>gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
          Length = 1200

 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 29/81 (35%), Positives = 40/81 (49%), Gaps = 12/81 (14%)

Query: 590 MPEECRATVQPAQTLTSECSRLCR--NGYCTPTGKCCCSPGWEGDFCRTAKCEPACRHGG 647
           M +EC+  V         C + C   +G CT  G+C CS GW+G FC      P C HG 
Sbjct: 236 MGKECKEAV---------CKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGS 286

Query: 648 VCVRPNKCLCKKGYLGPQCEQ 668
            CV P +C C+  + G  C++
Sbjct: 287 -CVEPWQCNCETNWGGLLCDK 306



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 24/73 (32%), Positives = 35/73 (47%), Gaps = 10/73 (13%)

Query: 605 TSECSRLCR--NGY-----CTPTGKCCCSPGWEGDFCRTAKCEPACR--HGGVCVRPNKC 655
           ++ C++ CR  N +     C   G   C  GW G  C+ A C+  C   HGG C  P +C
Sbjct: 204 SATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGG-CTVPGEC 262

Query: 656 LCKKGYLGPQCEQ 668
            C  G+ G  C++
Sbjct: 263 RCSYGWQGRFCDE 275



 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 26/66 (39%), Positives = 33/66 (50%), Gaps = 11/66 (16%)

Query: 612 CRNG-YCTPTG---KCCCSPGWEGDFCRTAK---CEP-ACRHGGVCVRPN---KCLCKKG 660
           C NG  C  +G   +C C PGW+G  C  AK   C P  C +GG CV       C+C+ G
Sbjct: 683 CSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDG 742

Query: 661 YLGPQC 666
           + G  C
Sbjct: 743 WEGRTC 748



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 25/91 (27%), Positives = 34/91 (37%), Gaps = 10/91 (10%)

Query: 590 MPEECRATVQPAQTLTSECSRL--CRNGYCTPTGKCCCSPGWEGDFC----RTAKCEPAC 643
           +P ECR +         EC     C +G C    +C C   W G  C            C
Sbjct: 258 VPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPC 317

Query: 644 RHGGVCVRPN----KCLCKKGYLGPQCEQVD 670
            +GG C+       +C C  GY G  CE+ +
Sbjct: 318 TNGGTCINAEPDQYRCTCPDGYSGRNCEKAE 348



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 26/76 (34%), Positives = 40/76 (52%), Gaps = 11/76 (14%)

Query: 605 TSECSRL-CRNGYCTPTG----KCCCSPGWEGDFCRTA--KCEPA-CRHGGVCV---RPN 653
           T++C+ L C NG     G    +C C+PG+ G  CR    +C+ + C +G  CV      
Sbjct: 752 TNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGY 811

Query: 654 KCLCKKGYLGPQCEQV 669
           +C C  G  GP+C++V
Sbjct: 812 RCSCPPGRAGPRCQEV 827



 Score = 36.6 bits (83), Expect = 0.081
 Identities = 17/50 (34%), Positives = 23/50 (46%), Gaps = 6/50 (12%)

Query: 623 CCCSPGWEGDFC--RTAKCEP-ACRHGGVCVRPN---KCLCKKGYLGPQC 666
           C C  GW+G  C  R  +C+   C +GG C       +C C  G+ G  C
Sbjct: 660 CACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTC 709



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 27/81 (33%), Positives = 34/81 (41%), Gaps = 16/81 (19%)

Query: 593 ECRATVQPAQTLTSECSRLCRNGYCTPTGKCCCSPGWEGDFCRTAKCEPA---CRHGGVC 649
           +CR   Q   T    C  L  NGY     +C C  G+ G  C   + E A   C  GG+C
Sbjct: 426 DCRGQCQHGGT----CKDLV-NGY-----QCVCPRGFGGRHCELERDECASSPCHSGGLC 475

Query: 650 ---VRPNKCLCKKGYLGPQCE 667
                   C C +G+ GP CE
Sbjct: 476 EDLADGFHCHCPQGFSGPLCE 496



 Score = 35.8 bits (81), Expect = 0.14
 Identities = 26/74 (35%), Positives = 35/74 (47%), Gaps = 11/74 (14%)

Query: 609 SRLCRNG---YCTPTG-KCCCSPGWEGDFCRTAKCEPA---CRHGGVCVRP---NKCLCK 658
           S  C NG   +  P+G +C C  GW G  C     E A   C  GG CV      +C+C 
Sbjct: 353 SNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICP 412

Query: 659 KGYLGPQCEQVDRN 672
           + ++G  C Q+D N
Sbjct: 413 EQWVGATC-QLDVN 425



 Score = 35.8 bits (81), Expect = 0.14
 Identities = 23/65 (35%), Positives = 26/65 (40%), Gaps = 10/65 (15%)

Query: 612 CRNGYC----TPTGKCCCSPGWEGDFCRT--AKCEP-ACRHGGVC---VRPNKCLCKKGY 661
           CRNG          +C C  GWEG+ C T    C P  C   G C   V    C C  G+
Sbjct: 607 CRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGW 666

Query: 662 LGPQC 666
            G  C
Sbjct: 667 KGKTC 671



 Score = 35.0 bits (79), Expect = 0.24
 Identities = 20/70 (28%), Positives = 29/70 (41%), Gaps = 16/70 (22%)

Query: 614 NGYCTPTGK----------CCCSPGWEGDFCRTAKCE---PACRHGGVC---VRPNKCLC 657
           +G C P G+          C C  G+ G +C     +     CR+GG C   V   +C C
Sbjct: 565 SGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFC 624

Query: 658 KKGYLGPQCE 667
             G+ G  C+
Sbjct: 625 PSGWEGELCD 634


>gi|21704277 jagged 2 isoform a precursor [Homo sapiens]
          Length = 1238

 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 29/81 (35%), Positives = 40/81 (49%), Gaps = 12/81 (14%)

Query: 590 MPEECRATVQPAQTLTSECSRLCR--NGYCTPTGKCCCSPGWEGDFCRTAKCEPACRHGG 647
           M +EC+  V         C + C   +G CT  G+C CS GW+G FC      P C HG 
Sbjct: 236 MGKECKEAV---------CKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGS 286

Query: 648 VCVRPNKCLCKKGYLGPQCEQ 668
            CV P +C C+  + G  C++
Sbjct: 287 -CVEPWQCNCETNWGGLLCDK 306



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 24/73 (32%), Positives = 35/73 (47%), Gaps = 10/73 (13%)

Query: 605 TSECSRLCR--NGY-----CTPTGKCCCSPGWEGDFCRTAKCEPACR--HGGVCVRPNKC 655
           ++ C++ CR  N +     C   G   C  GW G  C+ A C+  C   HGG C  P +C
Sbjct: 204 SATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGG-CTVPGEC 262

Query: 656 LCKKGYLGPQCEQ 668
            C  G+ G  C++
Sbjct: 263 RCSYGWQGRFCDE 275



 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 26/66 (39%), Positives = 33/66 (50%), Gaps = 11/66 (16%)

Query: 612 CRNG-YCTPTG---KCCCSPGWEGDFCRTAK---CEP-ACRHGGVCVRPN---KCLCKKG 660
           C NG  C  +G   +C C PGW+G  C  AK   C P  C +GG CV       C+C+ G
Sbjct: 721 CSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDG 780

Query: 661 YLGPQC 666
           + G  C
Sbjct: 781 WEGRTC 786



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 20/50 (40%), Positives = 26/50 (52%), Gaps = 5/50 (10%)

Query: 623 CCCSPGWEGDFC--RTAKCEPACRHGGVC---VRPNKCLCKKGYLGPQCE 667
           C C PGW+G  C      C   C+HGG C   V   +C+C +G+ G  CE
Sbjct: 447 CDCIPGWKGINCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCE 496



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 25/91 (27%), Positives = 34/91 (37%), Gaps = 10/91 (10%)

Query: 590 MPEECRATVQPAQTLTSECSRL--CRNGYCTPTGKCCCSPGWEGDFC----RTAKCEPAC 643
           +P ECR +         EC     C +G C    +C C   W G  C            C
Sbjct: 258 VPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPC 317

Query: 644 RHGGVCVRPN----KCLCKKGYLGPQCEQVD 670
            +GG C+       +C C  GY G  CE+ +
Sbjct: 318 TNGGTCINAEPDQYRCTCPDGYSGRNCEKAE 348



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 26/76 (34%), Positives = 40/76 (52%), Gaps = 11/76 (14%)

Query: 605 TSECSRL-CRNGYCTPTG----KCCCSPGWEGDFCRTA--KCEPA-CRHGGVCV---RPN 653
           T++C+ L C NG     G    +C C+PG+ G  CR    +C+ + C +G  CV      
Sbjct: 790 TNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGY 849

Query: 654 KCLCKKGYLGPQCEQV 669
           +C C  G  GP+C++V
Sbjct: 850 RCSCPPGRAGPRCQEV 865



 Score = 36.6 bits (83), Expect = 0.081
 Identities = 26/74 (35%), Positives = 35/74 (47%), Gaps = 11/74 (14%)

Query: 609 SRLCRNG---YCTPTG-KCCCSPGWEGDFCRTAKCEPA---CRHGGVCVRP---NKCLCK 658
           S  C NG   +  P+G +C C  GW G  C     E A   C  GG CV      +C+C 
Sbjct: 353 SNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICP 412

Query: 659 KGYLGPQCEQVDRN 672
           + ++G  C Q+D N
Sbjct: 413 EQWVGATC-QLDAN 425



 Score = 36.6 bits (83), Expect = 0.081
 Identities = 17/50 (34%), Positives = 23/50 (46%), Gaps = 6/50 (12%)

Query: 623 CCCSPGWEGDFC--RTAKCEP-ACRHGGVCVRPN---KCLCKKGYLGPQC 666
           C C  GW+G  C  R  +C+   C +GG C       +C C  G+ G  C
Sbjct: 698 CACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTC 747



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 27/81 (33%), Positives = 34/81 (41%), Gaps = 16/81 (19%)

Query: 593 ECRATVQPAQTLTSECSRLCRNGYCTPTGKCCCSPGWEGDFCRTAKCEPA---CRHGGVC 649
           +CR   Q   T    C  L  NGY     +C C  G+ G  C   + E A   C  GG+C
Sbjct: 464 DCRGQCQHGGT----CKDLV-NGY-----QCVCPRGFGGRHCELERDECASSPCHSGGLC 513

Query: 650 ---VRPNKCLCKKGYLGPQCE 667
                   C C +G+ GP CE
Sbjct: 514 EDLADGFHCHCPQGFSGPLCE 534



 Score = 35.8 bits (81), Expect = 0.14
 Identities = 23/65 (35%), Positives = 26/65 (40%), Gaps = 10/65 (15%)

Query: 612 CRNGYC----TPTGKCCCSPGWEGDFCRT--AKCEP-ACRHGGVC---VRPNKCLCKKGY 661
           CRNG          +C C  GWEG+ C T    C P  C   G C   V    C C  G+
Sbjct: 645 CRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGW 704

Query: 662 LGPQC 666
            G  C
Sbjct: 705 KGKTC 709



 Score = 35.0 bits (79), Expect = 0.24
 Identities = 20/70 (28%), Positives = 29/70 (41%), Gaps = 16/70 (22%)

Query: 614 NGYCTPTGK----------CCCSPGWEGDFCRTAKCE---PACRHGGVC---VRPNKCLC 657
           +G C P G+          C C  G+ G +C     +     CR+GG C   V   +C C
Sbjct: 603 SGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFC 662

Query: 658 KKGYLGPQCE 667
             G+ G  C+
Sbjct: 663 PSGWEGELCD 672


>gi|4557733 latent transforming growth factor beta binding protein 2
           [Homo sapiens]
          Length = 1821

 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 22/53 (41%), Positives = 31/53 (58%), Gaps = 6/53 (11%)

Query: 621 GKCCCSPGW----EGDFCRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQCEQV 669
           G+CC  PGW      + C    CEP C++ G C RP  C+C+ G+ G +CE+V
Sbjct: 171 GQCC--PGWTTANSTNHCIKPVCEPPCQNRGSCSRPQLCVCRSGFRGARCEEV 221



 Score = 29.6 bits (65), Expect = 9.9
 Identities = 23/94 (24%), Positives = 34/94 (36%), Gaps = 21/94 (22%)

Query: 584  DPKRPLMPEECRATVQPAQTLTSECSRLCRNGYCTPTGKCCCSPGWEGDFCRTAKCEPAC 643
            DP+   +  EC+ TV   Q L  +  +L     C    +C                E  C
Sbjct: 1141 DPQSSCLGGECKNTVGSYQCLCPQGFQLANGTVCEDVNEC--------------MGEEHC 1186

Query: 644  RHGGVCVRPNK---CLCKKGYL----GPQCEQVD 670
               G C+  +    CLC  G++    G  C+ VD
Sbjct: 1187 APHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVD 1220


>gi|223029476 NEL-like protein 2 isoform d [Homo sapiens]
          Length = 839

 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 21/47 (44%), Positives = 29/47 (61%), Gaps = 3/47 (6%)

Query: 623 CCCSPGWEGD--FCRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQCE 667
           C C PG+ G+   C+ A C+  CR+GG C+  N C C +G+ GP CE
Sbjct: 531 CVCKPGYTGNGTTCK-AFCKDGCRNGGACIAANVCACPQGFTGPSCE 576



 Score = 31.6 bits (70), Expect = 2.6
 Identities = 25/85 (29%), Positives = 31/85 (36%), Gaps = 17/85 (20%)

Query: 603 TLTSECSRLCRNG-YCTPTGKCCCSPGWEGDFCRT--AKCEPA---CRHGGVCVR-PN-- 653
           T  + C   CRNG  C     C C  G+ G  C T   +C      C     C+  P   
Sbjct: 543 TCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWY 602

Query: 654 KCLCKKGY--------LGPQCEQVD 670
            C C+ GY         G  CE +D
Sbjct: 603 HCECRDGYHDNGMFSPSGESCEDID 627


>gi|223029474 NEL-like protein 2 isoform c [Homo sapiens]
          Length = 815

 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 21/47 (44%), Positives = 29/47 (61%), Gaps = 3/47 (6%)

Query: 623 CCCSPGWEGD--FCRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQCE 667
           C C PG+ G+   C+ A C+  CR+GG C+  N C C +G+ GP CE
Sbjct: 507 CVCKPGYTGNGTTCK-AFCKDGCRNGGACIAANVCACPQGFTGPSCE 552



 Score = 31.6 bits (70), Expect = 2.6
 Identities = 25/85 (29%), Positives = 31/85 (36%), Gaps = 17/85 (20%)

Query: 603 TLTSECSRLCRNG-YCTPTGKCCCSPGWEGDFCRT--AKCEPA---CRHGGVCVR-PN-- 653
           T  + C   CRNG  C     C C  G+ G  C T   +C      C     C+  P   
Sbjct: 519 TCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWY 578

Query: 654 KCLCKKGY--------LGPQCEQVD 670
            C C+ GY         G  CE +D
Sbjct: 579 HCECRDGYHDNGMFSPSGESCEDID 603


>gi|223029472 NEL-like protein 2 isoform b precursor [Homo sapiens]
          Length = 816

 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 21/47 (44%), Positives = 29/47 (61%), Gaps = 3/47 (6%)

Query: 623 CCCSPGWEGD--FCRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQCE 667
           C C PG+ G+   C+ A C+  CR+GG C+  N C C +G+ GP CE
Sbjct: 508 CVCKPGYTGNGTTCK-AFCKDGCRNGGACIAANVCACPQGFTGPSCE 553



 Score = 31.6 bits (70), Expect = 2.6
 Identities = 25/85 (29%), Positives = 31/85 (36%), Gaps = 17/85 (20%)

Query: 603 TLTSECSRLCRNG-YCTPTGKCCCSPGWEGDFCRT--AKCEPA---CRHGGVCVR-PN-- 653
           T  + C   CRNG  C     C C  G+ G  C T   +C      C     C+  P   
Sbjct: 520 TCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWY 579

Query: 654 KCLCKKGY--------LGPQCEQVD 670
            C C+ GY         G  CE +D
Sbjct: 580 HCECRDGYHDNGMFSPSGESCEDID 604


>gi|223029470 NEL-like protein 2 isoform a [Homo sapiens]
          Length = 866

 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 21/47 (44%), Positives = 29/47 (61%), Gaps = 3/47 (6%)

Query: 623 CCCSPGWEGD--FCRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQCE 667
           C C PG+ G+   C+ A C+  CR+GG C+  N C C +G+ GP CE
Sbjct: 558 CVCKPGYTGNGTTCK-AFCKDGCRNGGACIAANVCACPQGFTGPSCE 603



 Score = 31.6 bits (70), Expect = 2.6
 Identities = 25/85 (29%), Positives = 31/85 (36%), Gaps = 17/85 (20%)

Query: 603 TLTSECSRLCRNG-YCTPTGKCCCSPGWEGDFCRT--AKCEPA---CRHGGVCVR-PN-- 653
           T  + C   CRNG  C     C C  G+ G  C T   +C      C     C+  P   
Sbjct: 570 TCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWY 629

Query: 654 KCLCKKGY--------LGPQCEQVD 670
            C C+ GY         G  CE +D
Sbjct: 630 HCECRDGYHDNGMFSPSGESCEDID 654


>gi|5453766 NEL-like protein 2 isoform b precursor [Homo sapiens]
          Length = 816

 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 21/47 (44%), Positives = 29/47 (61%), Gaps = 3/47 (6%)

Query: 623 CCCSPGWEGD--FCRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQCE 667
           C C PG+ G+   C+ A C+  CR+GG C+  N C C +G+ GP CE
Sbjct: 508 CVCKPGYTGNGTTCK-AFCKDGCRNGGACIAANVCACPQGFTGPSCE 553



 Score = 31.6 bits (70), Expect = 2.6
 Identities = 25/85 (29%), Positives = 31/85 (36%), Gaps = 17/85 (20%)

Query: 603 TLTSECSRLCRNG-YCTPTGKCCCSPGWEGDFCRT--AKCEPA---CRHGGVCVR-PN-- 653
           T  + C   CRNG  C     C C  G+ G  C T   +C      C     C+  P   
Sbjct: 520 TCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWY 579

Query: 654 KCLCKKGY--------LGPQCEQVD 670
            C C+ GY         G  CE +D
Sbjct: 580 HCECRDGYHDNGMFSPSGESCEDID 604


>gi|110735443 delta-like 1 [Homo sapiens]
          Length = 723

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 24/72 (33%), Positives = 35/72 (48%), Gaps = 8/72 (11%)

Query: 608 CSRLCR-------NGYCTPTGKCCCSPGWEGDFCRTAKCEPAC-RHGGVCVRPNKCLCKK 659
           CS  CR       +  C   G+  C+PGW+G +C    C P C    G C +P +C C+ 
Sbjct: 188 CSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKPGECKCRV 247

Query: 660 GYLGPQCEQVDR 671
           G+ G  C++  R
Sbjct: 248 GWQGRYCDECIR 259



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 21/56 (37%), Positives = 32/56 (57%), Gaps = 1/56 (1%)

Query: 613 RNGYCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQCEQ 668
           ++G+C   G+C C  GW+G +C      P C H G C +P +C C++G+ G  C Q
Sbjct: 233 QHGFCDKPGECKCRVGWQGRYCDECIRYPGCLH-GTCQQPWQCNCQEGWGGLFCNQ 287



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 27/87 (31%), Positives = 34/87 (39%), Gaps = 10/87 (11%)

Query: 591 PEECRATVQPAQTLTSECSRL--CRNGYCTPTGKCCCSPGWEGDFCRT----AKCEPACR 644
           P EC+  V        EC R   C +G C    +C C  GW G FC            C+
Sbjct: 240 PGECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCK 299

Query: 645 HGGVCVRPNK----CLCKKGYLGPQCE 667
           +G  C    +    C C+ GY G  CE
Sbjct: 300 NGATCTNTGQGSYTCSCRPGYTGATCE 326



 Score = 39.3 bits (90), Expect = 0.013
 Identities = 23/66 (34%), Positives = 29/66 (43%), Gaps = 10/66 (15%)

Query: 612 CRNGYCTPTG----KCCCSPGWEGDFCRT--AKCEPA-CRHGGVCVRPNK---CLCKKGY 661
           C NG     G     C C PG+ G  C    ++CE A C +G  C        C C +GY
Sbjct: 452 CANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGY 511

Query: 662 LGPQCE 667
            GP C+
Sbjct: 512 GGPNCQ 517



 Score = 34.3 bits (77), Expect = 0.40
 Identities = 23/68 (33%), Positives = 31/68 (45%), Gaps = 11/68 (16%)

Query: 612 CRNG-YCTP---TGKCCCSPGWEGDFCRTAK---CEPACRHGGVCV-RPN---KCLCKKG 660
           C+NG  CT    +  C C PG+ G  C  +     +  C +GG C   P+    C C  G
Sbjct: 337 CKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVG 396

Query: 661 YLGPQCEQ 668
           Y G  CE+
Sbjct: 397 YSGFNCEK 404


>gi|134244285 Notch homolog 3 [Homo sapiens]
          Length = 2321

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 34/86 (39%), Positives = 40/86 (46%), Gaps = 19/86 (22%)

Query: 602  QTLTSECSRL-CRNG-YCTPTGK-CCCSPGWEGDFC--RTAKC-----------EPACRH 645
            QTL   CSR  C+NG  C  TG  C C PGW G  C  R+  C           E  C+ 
Sbjct: 998  QTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQA 1057

Query: 646  GGVCVRPNK---CLCKKGYLGPQCEQ 668
            GG CV  +    C+C +G  G  CEQ
Sbjct: 1058 GGQCVDEDSSHYCVCPEGRTGSHCEQ 1083



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 29/79 (36%), Positives = 39/79 (49%), Gaps = 14/79 (17%)

Query: 600 PAQTLTSECSRLCRNGYCT--PTGK--CCCSPGWEGDFCRT----AKCEPACRHGGVCVR 651
           P   L+S C+   R   C+  P G+  C C PG++G  CR+     +    CRHGG C+ 
Sbjct: 120 PDPCLSSPCAHGAR---CSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLN 176

Query: 652 PN---KCLCKKGYLGPQCE 667
                +C C  GY GP CE
Sbjct: 177 TPGSFRCQCPAGYTGPLCE 195



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 37/115 (32%), Positives = 46/115 (40%), Gaps = 41/115 (35%)

Query: 593  ECRATVQPAQTLTSEC--------------SRLCRNGYC--------TPTG-KCCCSPGW 629
            +CR +  P   LT  C              +R CR   C        TP G +C C PG 
Sbjct: 1260 QCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGL 1319

Query: 630  EGDFCRT----------AKCEPA-CRHGGVCVRPN------KCLCKKGYLGPQCE 667
             G  CR+          A C  A C HGG C RP       +C C +G+ GP+CE
Sbjct: 1320 SGPSCRSFPGSPPGASNASCAAAPCLHGGSC-RPAPLAPFFRCACAQGWTGPRCE 1373



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 46/164 (28%), Positives = 63/164 (38%), Gaps = 43/164 (26%)

Query: 542  SCRGYFSGHILGFGEDELGEVYILSSSKSMTQTHNGKLYKIVDPKRPLMPE-----ECRA 596
            SC     G +    ED+ G    L S       HNG    +V   R   P       C A
Sbjct: 1147 SCPPGTLGVLCEINEDDCGPGPPLDSGPRCL--HNGTCVDLVGGFRCTCPPGYTGLRCEA 1204

Query: 597  TVQPAQTLTSECSRLCRNGYC----------TPTG--KCCCSPGWEGDFCRT--AKCEPA 642
             +             CR+G C           P G  +C C  G+ G  C+T  + CE  
Sbjct: 1205 DINE-----------CRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQ 1253

Query: 643  -CRHGGVCVRPNK---------CLCKKGYLGPQCEQVDRNIRRV 676
             C+HGG C RP+          C C + + GP+CE+V R+ R +
Sbjct: 1254 PCQHGGQC-RPSPGPGGGLTFTCHCAQPFWGPRCERVARSCREL 1296



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 33/118 (27%), Positives = 44/118 (37%), Gaps = 33/118 (27%)

Query: 584 DPKRPLMPEECR--ATVQPAQTLTSECSRL-------------------CRNGYCTPTG- 621
           +P  P  P  CR   T + +  LT +C+ L                   C NG     G 
Sbjct: 196 NPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGV 255

Query: 622 ---KCCCSPGWEGDFCR--TAKCE---PACRHGGVCVRP---NKCLCKKGYLGPQCEQ 668
               C C P W G FC     +C+    AC +GG C      + C+C  G+ G  C Q
Sbjct: 256 NTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQ 313



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 25/67 (37%), Positives = 28/67 (41%), Gaps = 11/67 (16%)

Query: 612 CRNGYC--TPTG-KCCCSPGWEGDFCRTAKCEPA-----CRHGGVCVRPN---KCLCKKG 660
           C +G C   P G +C C PGW G  C  +    A     CR GG C        C C  G
Sbjct: 704 CSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPG 763

Query: 661 YLGPQCE 667
             G QCE
Sbjct: 764 VQGRQCE 770



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 27/71 (38%), Positives = 33/71 (46%), Gaps = 10/71 (14%)

Query: 607 EC-SRLCRNGYCTP---TGKCCCSPGWEGDFCRT--AKCEPA-CRHGGVCV---RPNKCL 656
           EC S  C  G CT    +  C C PG+ G  C      C P+ C +GG CV       CL
Sbjct: 890 ECLSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCL 949

Query: 657 CKKGYLGPQCE 667
           C+ GY G  C+
Sbjct: 950 CRPGYTGAHCQ 960



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 32/75 (42%), Positives = 36/75 (48%), Gaps = 11/75 (14%)

Query: 607 EC-SRLCRNGY-CT--PTG-KCCCSPGWEGDFC--RTAKCEPACRHGGVCV---RPNKCL 656
           EC S  CRNG  C   P G +C C+ G+EG  C      C P   H G CV       C 
Sbjct: 510 ECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCA 569

Query: 657 CKKGYLGPQCE-QVD 670
           C  GY G +CE QVD
Sbjct: 570 CAPGYTGTRCESQVD 584



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 23/67 (34%), Positives = 32/67 (47%), Gaps = 12/67 (17%)

Query: 612 CRNGYCTPTG----KCCCSPGWEGDFCRTAKCEPA----CRHGGVCVRPN---KCLCKKG 660
           C NG     G     C C PG+ G  C+  + +P     C HGGVC   +   +C C + 
Sbjct: 933 CFNGGTCVDGVNSFSCLCRPGYTGAHCQH-EADPCLSRPCLHGGVCSAAHPGFRCTCLES 991

Query: 661 YLGPQCE 667
           + GPQC+
Sbjct: 992 FTGPQCQ 998



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 29/83 (34%), Positives = 32/83 (38%), Gaps = 14/83 (16%)

Query: 594  CRATVQPAQTLTSECSRLCRN---GYCTPTGKCCCSPGWEGDFCRTAKCEPA---CRHGG 647
            C   V P      +    CR    GY      C C PG+ GD C     E A   C+HGG
Sbjct: 1081 CEQEVDPCLAQPCQHGGTCRGYMGGYM-----CECLPGYNGDNCEDDVDECASQPCQHGG 1135

Query: 648  VC---VRPNKCLCKKGYLGPQCE 667
             C   V    C C  G LG  CE
Sbjct: 1136 SCIDLVARYLCSCPPGTLGVLCE 1158



 Score = 38.1 bits (87), Expect = 0.028
 Identities = 33/108 (30%), Positives = 39/108 (36%), Gaps = 12/108 (11%)

Query: 569 KSMTQTHNGKLYKIVDPKRPLMPEECRATVQPAQTLTSEC-SRLCRNGYCTP---TGKCC 624
           +S    H GK   +VD      P     T    +    +C S  C  G C        C 
Sbjct: 587 RSQPCRHGGKCLDLVDKYLCRCPSG--TTGVNCEVNIDDCASNPCTFGVCRDGINRYDCV 644

Query: 625 CSPGWEGDFCRTAKCEPA---CRHGGVCVRPN---KCLCKKGYLGPQC 666
           C PG+ G  C     E A   C  GG CV      +CLC  G L P C
Sbjct: 645 CQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLC 692



 Score = 38.1 bits (87), Expect = 0.028
 Identities = 19/53 (35%), Positives = 23/53 (43%), Gaps = 7/53 (13%)

Query: 623 CCCSPGWEGDFCRTAKCEPA----CRHGGVCVR---PNKCLCKKGYLGPQCEQ 668
           C C  GW+G  C+    E A    C   G+C        C C  GY GP C+Q
Sbjct: 796 CSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQ 848



 Score = 37.7 bits (86), Expect = 0.036
 Identities = 20/53 (37%), Positives = 24/53 (45%), Gaps = 8/53 (15%)

Query: 623 CCCSPGWEGDFCRTAKCEPA-----CRHGGVCVRPNK---CLCKKGYLGPQCE 667
           C C PG+ G  C     E +     C H G CV       C C +GY GP+CE
Sbjct: 377 CTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCE 429



 Score = 37.0 bits (84), Expect = 0.062
 Identities = 25/76 (32%), Positives = 29/76 (38%), Gaps = 20/76 (26%)

Query: 612 CRNG-YCTPT----GKCCCSPGWEGDFCRTAKCEPACRHG-----GVC-------VRPNK 654
           C NG  CT        C C PGW G+ C   + E  C  G     GVC            
Sbjct: 49  CANGGRCTQLPSREAACLCPPGWVGERC---QLEDPCHSGPCAGRGVCQSSVVAGTARFS 105

Query: 655 CLCKKGYLGPQCEQVD 670
           C C +G+ GP C   D
Sbjct: 106 CRCPRGFRGPDCSLPD 121



 Score = 33.1 bits (74), Expect = 0.90
 Identities = 23/73 (31%), Positives = 28/73 (38%), Gaps = 17/73 (23%)

Query: 612 CRNGY-CTPTGKCC---------CSPGWEGDFCR--TAKCEPA-CRHGGVCVRPN----K 654
           CR G  C   G C          C  G+ G  C      C P+ CR+GG C +       
Sbjct: 162 CRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYD 221

Query: 655 CLCKKGYLGPQCE 667
           C C  G+ G  CE
Sbjct: 222 CACLPGFEGQNCE 234



 Score = 32.0 bits (71), Expect = 2.0
 Identities = 16/52 (30%), Positives = 22/52 (42%), Gaps = 5/52 (9%)

Query: 622 KCCCSPGWEGDFCRTAK---CEPACRHGGVCVRPN--KCLCKKGYLGPQCEQ 668
           +C C PG     C           C HG     P   +C+C+ G+ GP+C Q
Sbjct: 680 RCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQ 731



 Score = 31.2 bits (69), Expect = 3.4
 Identities = 24/71 (33%), Positives = 26/71 (36%), Gaps = 19/71 (26%)

Query: 612 CRNGYCTPTG----KCCCSPGWEG-------DFCRTAKCEPACRHGGVC---VRPNKCLC 657
           C NG     G     C C PG+ G       D C +  C P     G C   V    C C
Sbjct: 858 CLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGP-----GTCTDHVASFTCTC 912

Query: 658 KKGYLGPQCEQ 668
             GY G  CEQ
Sbjct: 913 PPGYGGFHCEQ 923



 Score = 31.2 bits (69), Expect = 3.4
 Identities = 15/49 (30%), Positives = 18/49 (36%), Gaps = 1/49 (2%)

Query: 612  CRNGYCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKG 660
            CR     P  +C C+ GW G  C      P       C R   C  K+G
Sbjct: 1350 CRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRA-ACQAKRG 1397



 Score = 30.4 bits (67), Expect = 5.8
 Identities = 21/80 (26%), Positives = 28/80 (35%), Gaps = 6/80 (7%)

Query: 594 CRATVQPAQTLTSECSRLCRNGYCTPTGKCCCSPGWEGDFCRTAKCE---PACRHGGVC- 649
           C   V       + C  L R      +  C C  G+ G  C T   E     CR+   C 
Sbjct: 388 CDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCL 447

Query: 650 --VRPNKCLCKKGYLGPQCE 667
             +    C+C  G+ G  CE
Sbjct: 448 DRIGQFTCICMAGFTGTYCE 467


>gi|188528648 tenascin XB isoform 1 precursor [Homo sapiens]
          Length = 4242

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 23/59 (38%), Positives = 28/59 (47%), Gaps = 1/59 (1%)

Query: 608 CSRLCRNGYCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQC 666
           C R C        G+C C PG+ G+ C T  C   C  GG CV   +C+C  GY G  C
Sbjct: 311 CPRGCSQRGRCKDGRCVCDPGYTGEDCGTRSCPWDCGEGGRCV-DGRCVCWPGYTGEDC 368



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 24/73 (32%), Positives = 28/73 (38%), Gaps = 1/73 (1%)

Query: 594 CRATVQPAQTLTSECSRLCRNGYCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPN 653
           CRA           C R C        G+C C PG+ GD C    C   C   G C    
Sbjct: 235 CRAGFSGPDCSQRSCPRGCSQRGRCEGGRCVCDPGYTGDDCGMRSCPRGCSQRGRC-ENG 293

Query: 654 KCLCKKGYLGPQC 666
           +C+C  GY G  C
Sbjct: 294 RCVCNPGYTGEDC 306



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 24/61 (39%), Positives = 27/61 (44%), Gaps = 1/61 (1%)

Query: 608 CSRLCRNGYCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQCE 667
           C   C        G+C C PG+ G  C T  C   CR  G CV+   CLC  GY G  C 
Sbjct: 621 CPSNCHGRGRCEEGRCLCDPGYTGPTCATRMCPADCRGRGRCVQ-GVCLCHVGYGGEDCG 679

Query: 668 Q 668
           Q
Sbjct: 680 Q 680



 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 23/62 (37%), Positives = 28/62 (45%), Gaps = 1/62 (1%)

Query: 605 TSECSRLCRNGYCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKGYLGP 664
           T  C   C  G     G+C C PG+ G+ C T  C   CR  G C    +C+C  GY G 
Sbjct: 339 TRSCPWDCGEGGRCVDGRCVCWPGYTGEDCSTRTCPRDCRGRGRC-EDGECICDTGYSGD 397

Query: 665 QC 666
            C
Sbjct: 398 DC 399



 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 22/62 (35%), Positives = 30/62 (48%), Gaps = 1/62 (1%)

Query: 605 TSECSRLCRNGYCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKGYLGP 664
           T  C   CR       G+C C+PG+ G+ C + +C   CR  G+C     C+C  GY G 
Sbjct: 494 TRACPGDCRGRGRCVDGRCVCNPGFTGEDCGSRRCPGDCRGHGLC-EDGVCVCDAGYSGE 552

Query: 665 QC 666
            C
Sbjct: 553 DC 554



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 20/59 (33%), Positives = 27/59 (45%), Gaps = 1/59 (1%)

Query: 608 CSRLCRNGYCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQC 666
           C R C        G+C C+PG+ G+ C    C   C   G C +  +C+C  GY G  C
Sbjct: 280 CPRGCSQRGRCENGRCVCNPGYTGEDCGVRSCPRGCSQRGRC-KDGRCVCDPGYTGEDC 337



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 21/59 (35%), Positives = 27/59 (45%), Gaps = 1/59 (1%)

Query: 608 CSRLCRNGYCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQC 666
           C   CR       G C C  G+ G+ C T  C   CR  G C+   +C+C+ GY G  C
Sbjct: 528 CPGDCRGHGLCEDGVCVCDAGYSGEDCSTRSCPGGCRGRGQCL-DGRCVCEDGYSGEDC 585



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 24/83 (28%), Positives = 37/83 (44%), Gaps = 3/83 (3%)

Query: 588 PLMPEECRATVQPAQ--TLTSECSRLCRNGYCTPTGKCCCSPGWEGDFCRTAKCEPACRH 645
           P   +   A + P+   + +  C   C +      G+C C PG+ G  C    C   C+ 
Sbjct: 165 PTCSDPTDAEIPPSSPPSASGSCPDDCNDQGRCVRGRCVCFPGYTGPSCGWPSCPGDCQG 224

Query: 646 GGVCVRPNKCLCKKGYLGPQCEQ 668
            G CV+   C+C+ G+ GP C Q
Sbjct: 225 RGRCVQ-GVCVCRAGFSGPDCSQ 246



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 22/62 (35%), Positives = 26/62 (41%), Gaps = 1/62 (1%)

Query: 605 TSECSRLCRNGYCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKGYLGP 664
           T  C R CR       G+C C  G+ GD C    C   C   G C    +C+C  GY G 
Sbjct: 370 TRTCPRDCRGRGRCEDGECICDTGYSGDDCGVRSCPGDCNQRGRC-EDGRCVCWPGYTGT 428

Query: 665 QC 666
            C
Sbjct: 429 DC 430



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 24/73 (32%), Positives = 30/73 (41%), Gaps = 1/73 (1%)

Query: 594 CRATVQPAQTLTSECSRLCRNGYCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPN 653
           C A           C   CR      +G+C C PG+ G  C T  C   CR  G CV   
Sbjct: 452 CNAGYSGEDCGVRSCPGDCRGRGRCESGRCMCWPGYTGRDCGTRACPGDCRGRGRCV-DG 510

Query: 654 KCLCKKGYLGPQC 666
           +C+C  G+ G  C
Sbjct: 511 RCVCNPGFTGEDC 523



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 26/79 (32%), Positives = 32/79 (40%), Gaps = 5/79 (6%)

Query: 592 EECRATVQPAQTLTS----ECSRLCRNGYCTPTGKCCCSPGWEGDFCRTAKCEPACRHGG 647
           E+ R    P  T T      C R CR       G C C+ G+ G+ C    C   CR  G
Sbjct: 415 EDGRCVCWPGYTGTDCGSRACPRDCRGRGRCENGVCVCNAGYSGEDCGVRSCPGDCRGRG 474

Query: 648 VCVRPNKCLCKKGYLGPQC 666
            C    +C+C  GY G  C
Sbjct: 475 RC-ESGRCMCWPGYTGRDC 492



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 26/77 (33%), Positives = 30/77 (38%), Gaps = 9/77 (11%)

Query: 592 EECRATVQPAQTLTSECS--RLCRNGYCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVC 649
           E+C     PA      C    LCR       G+C C  G+ G  C    C   CR  G C
Sbjct: 676 EDCGQEEPPASACPGGCGPRELCR------AGQCVCVEGFRGPDCAIQTCPGDCRGRGEC 729

Query: 650 VRPNKCLCKKGYLGPQC 666
                C+CK GY G  C
Sbjct: 730 -HDGSCVCKDGYAGEDC 745



 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 24/74 (32%), Positives = 32/74 (43%), Gaps = 3/74 (4%)

Query: 594 CRATVQPAQTLTSECSRLCRN-GYCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRP 652
           C A        T  C   CR  G C   G+C C  G+ G+ C   +C   C   GVC + 
Sbjct: 545 CDAGYSGEDCSTRSCPGGCRGRGQCLD-GRCVCEDGYSGEDCGVRQCPNDCSQHGVC-QD 602

Query: 653 NKCLCKKGYLGPQC 666
             C+C +GY+   C
Sbjct: 603 GVCICWEGYVSEDC 616



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 20/59 (33%), Positives = 23/59 (38%), Gaps = 16/59 (27%)

Query: 623 CCCSPGWEGDFC---------------RTAKCEPACRHGGVCVRPNKCLCKKGYLGPQC 666
           C C PGW G  C                +  C   C   G CVR  +C+C  GY GP C
Sbjct: 156 CSCEPGWGGPTCSDPTDAEIPPSSPPSASGSCPDDCNDQGRCVR-GRCVCFPGYTGPSC 213



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 19/60 (31%), Positives = 23/60 (38%), Gaps = 1/60 (1%)

Query: 607 ECSRLCRNGYCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQC 666
           +C   C        G C C  G+  + C    C   C   G C    +CLC  GY GP C
Sbjct: 589 QCPNDCSQHGVCQDGVCICWEGYVSEDCSIRTCPSNCHGRGRC-EEGRCLCDPGYTGPTC 647



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 16/46 (34%), Positives = 19/46 (41%), Gaps = 1/46 (2%)

Query: 621 GKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQC 666
           G C C  G+ G  C    C   C   G C    +C+C  GY G  C
Sbjct: 231 GVCVCRAGFSGPDCSQRSCPRGCSQRGRC-EGGRCVCDPGYTGDDC 275



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 25/85 (29%), Positives = 36/85 (42%), Gaps = 12/85 (14%)

Query: 592 EECRATVQPAQTLTSECSRLCR-----NGYCTPTGKCCCSPGWEGDFC-----RTAKCEP 641
           EE R    P  T  +  +R+C       G C   G C C  G+ G+ C       + C  
Sbjct: 632 EEGRCLCDPGYTGPTCATRMCPADCRGRGRCVQ-GVCLCHVGYGGEDCGQEEPPASACPG 690

Query: 642 ACRHGGVCVRPNKCLCKKGYLGPQC 666
            C    +C R  +C+C +G+ GP C
Sbjct: 691 GCGPRELC-RAGQCVCVEGFRGPDC 714


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.141    0.443 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,655,417
Number of Sequences: 37866
Number of extensions: 1545702
Number of successful extensions: 5153
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 118
Number of HSP's successfully gapped in prelim test: 165
Number of HSP's that attempted gapping in prelim test: 3413
Number of HSP's gapped (non-prelim): 1349
length of query: 700
length of database: 18,247,518
effective HSP length: 109
effective length of query: 591
effective length of database: 14,120,124
effective search space: 8344993284
effective search space used: 8344993284
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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