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Search of human proteins with 20143912
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo
sapiens]
(275 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo ... 573 e-164
gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo ... 547 e-156
gi|8923881 WD SOCS-box protein 2 [Homo sapiens] 299 2e-81
gi|113865883 WD repeat domain 38 [Homo sapiens] 120 2e-27
gi|16554629 WD repeat domain 5 [Homo sapiens] 104 7e-23
gi|16554627 WD repeat domain 5 [Homo sapiens] 104 7e-23
gi|23199987 WD repeat domain 5B [Homo sapiens] 101 8e-22
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 89 5e-18
gi|26665869 WD repeat domain 51B [Homo sapiens] 87 2e-17
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 84 1e-16
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 84 1e-16
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 82 5e-16
gi|21071067 TBP-associated factor 5 [Homo sapiens] 81 9e-16
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa... 81 9e-16
gi|189571685 WD repeat, sterile alpha motif and U-box domain con... 79 6e-15
gi|189571683 WD repeat, sterile alpha motif and U-box domain con... 79 6e-15
gi|189571681 WD repeat, sterile alpha motif and U-box domain con... 79 6e-15
gi|62234438 Notchless gene homolog isoform b [Homo sapiens] 77 1e-14
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 77 2e-14
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H... 77 2e-14
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 77 2e-14
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho... 77 2e-14
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 77 2e-14
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 77 2e-14
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 77 2e-14
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 77 2e-14
gi|32189425 WD repeat domain 69 [Homo sapiens] 77 2e-14
gi|13376840 WD repeat domain 61 [Homo sapiens] 76 4e-14
gi|5902134 coronin, actin binding protein, 1A [Homo sapiens] 75 8e-14
gi|4757988 WD repeat domain 39 [Homo sapiens] 74 1e-13
>gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo
sapiens]
Length = 275
Score = 573 bits (1477), Expect = e-164
Identities = 275/275 (100%), Positives = 275/275 (100%)
Query: 1 MASFPPRVNEKEIGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNM 60
MASFPPRVNEKEIGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNM
Sbjct: 1 MASFPPRVNEKEIGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNM 60
Query: 61 MKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSP 120
MKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSP
Sbjct: 61 MKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSP 120
Query: 121 DGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHV 180
DGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHV
Sbjct: 121 DGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHV 180
Query: 181 ASLADDKMVRFWRIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQVPS 240
ASLADDKMVRFWRIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQVPS
Sbjct: 181 ASLADDKMVRFWRIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQVPS 240
Query: 241 LQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYRI 275
LQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYRI
Sbjct: 241 LQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYRI 275
>gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo
sapiens]
Length = 421
Score = 547 bits (1410), Expect = e-156
Identities = 262/262 (100%), Positives = 262/262 (100%)
Query: 14 GKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYS 73
GKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYS
Sbjct: 160 GKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYS 219
Query: 74 CAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTR 133
CAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTR
Sbjct: 220 CAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTR 279
Query: 134 VYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWR 193
VYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWR
Sbjct: 280 VYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWR 339
Query: 194 IDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQVPSLQHLCRMSIRRVM 253
IDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQVPSLQHLCRMSIRRVM
Sbjct: 340 IDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQVPSLQHLCRMSIRRVM 399
Query: 254 PTQEVQELPIPSKLLEFLSYRI 275
PTQEVQELPIPSKLLEFLSYRI
Sbjct: 400 PTQEVQELPIPSKLLEFLSYRI 421
Score = 66.2 bits (160), Expect = 3e-11
Identities = 75/295 (25%), Positives = 114/295 (38%), Gaps = 75/295 (25%)
Query: 1 MASFPPRVNEKEI------GKLLLNLVDHTEVVR----DLTFAPDGSLILVS-------- 42
MASFPPRVNEKEI G+LL + + FAPDGS S
Sbjct: 1 MASFPPRVNEKEIVRLRTIGELLAPAAPFDKKCGRENWTVAFAPDGSYFAWSQGHRTVKL 60
Query: 43 -----------------ASRDKTLRVWDLKDDGNMMKVLRGH----QNWVYSCAFSPD-- 79
+ +LR+ DG R H + V+S AF
Sbjct: 61 VPWSQCLQNFLLHGTKNVTNSSSLRLPRQNSDGGQKNKPREHIIDCGDIVWSLAFGSSVP 120
Query: 80 ------------------SSMLCSVGASKA-VFLWNMDKYTMIRKLEGHHHDVVACDFSP 120
+L + G + + +W++ ++ L H V F+P
Sbjct: 121 EKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAP 180
Query: 121 DGAL-LATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLH 179
DG+L L +AS D + +WD + +M+ + G N WV S +FS D
Sbjct: 181 DGSLILVSASRDKTLRVWDLKDDGNMMK----------VLRGHQN--WVYSCAFSPDSSM 228
Query: 180 VASLADDKMVRFWRIDEDYPVQ--VAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 232
+ S+ K V W +D+ ++ + + C FS DG++LA ++D VY W
Sbjct: 229 LCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIW 283
>gi|8923881 WD SOCS-box protein 2 [Homo sapiens]
Length = 404
Score = 299 bits (765), Expect = 2e-81
Identities = 143/268 (53%), Positives = 184/268 (68%), Gaps = 1/268 (0%)
Query: 7 RVNEKEIGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRG 66
++ E + G LLLNL H +VVRDL+F P GSLILVSASRDKTLR+WDL G ++VL G
Sbjct: 136 KIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQIQVLSG 195
Query: 67 HQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLA 126
H WVY C+ SPD SMLCS K+VFLW+M YT+IRKLEGH VV+CDFSPD ALL
Sbjct: 196 HLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLV 255
Query: 127 TASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADD 186
TASYDT V +WDP+ G+ L H P + + +RSV FS +GL++A++ADD
Sbjct: 256 TASYDTNVIMWDPYTGERLRSLHHTQVDPA-MDDSDVHISSLRSVCFSPEGLYLATVADD 314
Query: 187 KMVRFWRIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQVPSLQHLCR 246
+++R W ++ P+ AP++NGLCC F G V+A GT DG V FW PR + SL+HLCR
Sbjct: 315 RLLRIWALELKTPIAFAPMTNGLCCTFFPHGGVIATGTRDGHVQFWTAPRVLSSLKHLCR 374
Query: 247 MSIRRVMPTQEVQELPIPSKLLEFLSYR 274
++R + T +V LPIP K+ EFL+YR
Sbjct: 375 KALRSFLTTYQVLALPIPKKMKEFLTYR 402
Score = 47.4 bits (111), Expect = 1e-05
Identities = 40/137 (29%), Positives = 64/137 (46%), Gaps = 26/137 (18%)
Query: 104 RKLEGHHHDVVACDFSPDGA--LLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAG 161
RKL HH V PD + +LAT D ++ IW+ G +L+
Sbjct: 108 RKLWARHHPQV-----PDVSCLVLATGLNDGQIKIWEVQTGLLLLNL------------- 149
Query: 162 GANDRWVRSVSFSHDG-LHVASLADDKMVRFWRIDEDYPVQVAPLSNGL----CCAFSTD 216
+ VR +SF+ G L + S + DK +R W +++ + Q+ LS L CC+ S D
Sbjct: 150 SGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNK-HGKQIQVLSGHLQWVYCCSISPD 208
Query: 217 GSVLAAGTHDGSVYFWA 233
S+L + + SV+ W+
Sbjct: 209 CSMLCSAAGEKSVFLWS 225
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 120 bits (300), Expect = 2e-27
Identities = 85/250 (34%), Positives = 123/250 (49%), Gaps = 35/250 (14%)
Query: 10 EKEIGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQN 69
E G+LL L HT V+ F+PDG L SAS D T+R+WD+ ++VL+GHQ
Sbjct: 49 ETRSGQLLWRLGGHTGPVKFCRFSPDGHLF-ASASCDCTVRLWDVAR-AKCLRVLKGHQR 106
Query: 70 WVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATAS 129
V + +FSPDS L S G K V LW++ M+R L GH + + DFSP LAT S
Sbjct: 107 SVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGS 166
Query: 130 YDTRVYIWD--------------PHNGDI---------LMEFG------HLFPPPTP--I 158
+D+ V+IWD H+ +I L+ G H++ P T +
Sbjct: 167 WDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLL 226
Query: 159 FAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQV--APLSNGLCCAFSTD 216
+ WV+S++FS D L +AS +MV+ W + ++ L CAF+ D
Sbjct: 227 IQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPD 286
Query: 217 GSVLAAGTHD 226
G +L +G D
Sbjct: 287 GKILVSGAAD 296
Score = 76.3 bits (186), Expect = 3e-14
Identities = 58/186 (31%), Positives = 78/186 (41%), Gaps = 17/186 (9%)
Query: 61 MKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSP 120
+K H V S AFSPD ML + V+ W ++ +L GH V C FSP
Sbjct: 14 VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSP 73
Query: 121 DGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLH 179
DG L A+AS D V +WD L GH R V +VSFS D
Sbjct: 74 DGHLFASASCDCTVRLWDVARAKCLRVLKGH--------------QRSVETVSFSPDSRQ 119
Query: 180 VASLADDKMVRFWRIDEDYPVQ--VAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQ 237
+AS DK V W + ++ V + FS + LA G+ D +V+ W
Sbjct: 120 LASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMV 179
Query: 238 VPSLQH 243
P++ H
Sbjct: 180 TPAVSH 185
Score = 68.6 bits (166), Expect = 6e-12
Identities = 50/169 (29%), Positives = 79/169 (46%), Gaps = 12/169 (7%)
Query: 14 GKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLK--DDGNMMKVLRGHQNWV 71
G++L LV H + ++ F+P + L + S D T+ +WDL+ + L GH +
Sbjct: 137 GQMLRLLVGHRDSIQSSDFSPTVNC-LATGSWDSTVHIWDLRMVTPAVSHQALEGHSANI 195
Query: 72 YSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYD 131
SC S +L S K + +W +++ +L+GH V + FSPD LA+A Y
Sbjct: 196 -SCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYS 254
Query: 132 TRVYIWDPHNGDIL------MEFGH--LFPPPTPIFAGGANDRWVRSVS 172
V +WD + G L ++ H F P I GA D+ R +S
Sbjct: 255 RMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRRQIS 303
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 104 bits (260), Expect = 7e-23
Identities = 66/224 (29%), Positives = 109/224 (48%), Gaps = 19/224 (8%)
Query: 14 GKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYS 73
GK + H + D+ ++ D +L LVSAS DKTL++WD+ G +K L+GH N+V+
Sbjct: 77 GKFEKTISGHKLGISDVAWSSDSNL-LVSASDDKTLKIWDVSS-GKCLKTLKGHSNYVFC 134
Query: 74 CAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTR 133
C F+P S+++ S ++V +W++ ++ L H V A F+ DG+L+ ++SYD
Sbjct: 135 CNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGL 194
Query: 134 VYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWR 193
IWD +G L PP V V FS +G ++ + D ++ W
Sbjct: 195 CRIWDTASGQCLKTLIDDDNPP------------VSFVKFSPNGKYILAATLDNTLKLWD 242
Query: 194 IDEDYPVQV-APLSNGLCCAFS----TDGSVLAAGTHDGSVYFW 232
+ ++ N C F+ T G + +G+ D VY W
Sbjct: 243 YSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW 286
Score = 97.8 bits (242), Expect = 9e-21
Identities = 66/227 (29%), Positives = 105/227 (46%), Gaps = 32/227 (14%)
Query: 16 LLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCA 75
L L HT+ V + F+P+G L S+S DK +++W D G K + GH+ + A
Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEW-LASSSADKLIKIWGAYD-GKFEKTISGHKLGISDVA 94
Query: 76 FSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVY 135
+S DS++L S K + +W++ ++ L+GH + V C+F+P L+ + S+D V
Sbjct: 95 WSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154
Query: 136 IWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW--- 192
IWD G L A+ V +V F+ DG + S + D + R W
Sbjct: 155 IWDVKTGKCLKTL-------------PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 201
Query: 193 -------RIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 232
ID+D P P+S FS +G + A T D ++ W
Sbjct: 202 SGQCLKTLIDDDNP----PVS---FVKFSPNGKYILAATLDNTLKLW 241
Score = 61.2 bits (147), Expect = 9e-10
Identities = 46/174 (26%), Positives = 72/174 (41%), Gaps = 17/174 (9%)
Query: 64 LRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGA 123
L GH V S FSP+ L S A K + +W + + GH + +S D
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
Query: 124 LLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVAS 182
LL +AS D + IWD +G L GH +V +F+ + S
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGH--------------SNYVFCCNFNPQSNLIVS 146
Query: 183 LADDKMVRFWRIDEDYPVQVAPLSNGLCCA--FSTDGSVLAAGTHDGSVYFWAT 234
+ D+ VR W + ++ P + A F+ DGS++ + ++DG W T
Sbjct: 147 GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200
Score = 59.3 bits (142), Expect = 4e-09
Identities = 51/194 (26%), Positives = 86/194 (44%), Gaps = 19/194 (9%)
Query: 7 RVNEKEIGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRG 66
R+ + + GK L L H++ V + F DGSLI VS+S D R+WD G +K L
Sbjct: 154 RIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLI-VSSSYDGLCRIWDTA-SGQCLKTLID 211
Query: 67 HQNWVYS-CAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHD--VVACDFS-PDG 122
N S FSP+ + + + LW+ K ++ GH ++ + +FS G
Sbjct: 212 DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGG 271
Query: 123 ALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHV-A 181
+ + S D VYIW+ +I+ + G D + + + + A
Sbjct: 272 KWIVSGSEDNLVYIWNLQTKEIVQKL------------QGHTDVVISTACHPTENIIASA 319
Query: 182 SLADDKMVRFWRID 195
+L +DK ++ W+ D
Sbjct: 320 ALENDKTIKLWKSD 333
Score = 50.8 bits (120), Expect = 1e-06
Identities = 36/136 (26%), Positives = 61/136 (44%), Gaps = 17/136 (12%)
Query: 100 YTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPI 158
Y + L GH V + FSP+G LA++S D + IW ++G GH
Sbjct: 35 YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKL------ 88
Query: 159 FAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTD 216
G +D V++S D + S +DDK ++ W + ++ + CC F+
Sbjct: 89 ---GISD-----VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ 140
Query: 217 GSVLAAGTHDGSVYFW 232
+++ +G+ D SV W
Sbjct: 141 SNLIVSGSFDESVRIW 156
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 104 bits (260), Expect = 7e-23
Identities = 66/224 (29%), Positives = 109/224 (48%), Gaps = 19/224 (8%)
Query: 14 GKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYS 73
GK + H + D+ ++ D +L LVSAS DKTL++WD+ G +K L+GH N+V+
Sbjct: 77 GKFEKTISGHKLGISDVAWSSDSNL-LVSASDDKTLKIWDVSS-GKCLKTLKGHSNYVFC 134
Query: 74 CAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTR 133
C F+P S+++ S ++V +W++ ++ L H V A F+ DG+L+ ++SYD
Sbjct: 135 CNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGL 194
Query: 134 VYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWR 193
IWD +G L PP V V FS +G ++ + D ++ W
Sbjct: 195 CRIWDTASGQCLKTLIDDDNPP------------VSFVKFSPNGKYILAATLDNTLKLWD 242
Query: 194 IDEDYPVQV-APLSNGLCCAFS----TDGSVLAAGTHDGSVYFW 232
+ ++ N C F+ T G + +G+ D VY W
Sbjct: 243 YSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW 286
Score = 97.8 bits (242), Expect = 9e-21
Identities = 66/227 (29%), Positives = 105/227 (46%), Gaps = 32/227 (14%)
Query: 16 LLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCA 75
L L HT+ V + F+P+G L S+S DK +++W D G K + GH+ + A
Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEW-LASSSADKLIKIWGAYD-GKFEKTISGHKLGISDVA 94
Query: 76 FSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVY 135
+S DS++L S K + +W++ ++ L+GH + V C+F+P L+ + S+D V
Sbjct: 95 WSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154
Query: 136 IWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW--- 192
IWD G L A+ V +V F+ DG + S + D + R W
Sbjct: 155 IWDVKTGKCLKTL-------------PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 201
Query: 193 -------RIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 232
ID+D P P+S FS +G + A T D ++ W
Sbjct: 202 SGQCLKTLIDDDNP----PVS---FVKFSPNGKYILAATLDNTLKLW 241
Score = 61.2 bits (147), Expect = 9e-10
Identities = 46/174 (26%), Positives = 72/174 (41%), Gaps = 17/174 (9%)
Query: 64 LRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGA 123
L GH V S FSP+ L S A K + +W + + GH + +S D
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
Query: 124 LLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVAS 182
LL +AS D + IWD +G L GH +V +F+ + S
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGH--------------SNYVFCCNFNPQSNLIVS 146
Query: 183 LADDKMVRFWRIDEDYPVQVAPLSNGLCCA--FSTDGSVLAAGTHDGSVYFWAT 234
+ D+ VR W + ++ P + A F+ DGS++ + ++DG W T
Sbjct: 147 GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200
Score = 59.3 bits (142), Expect = 4e-09
Identities = 51/194 (26%), Positives = 86/194 (44%), Gaps = 19/194 (9%)
Query: 7 RVNEKEIGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRG 66
R+ + + GK L L H++ V + F DGSLI VS+S D R+WD G +K L
Sbjct: 154 RIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLI-VSSSYDGLCRIWDTA-SGQCLKTLID 211
Query: 67 HQNWVYS-CAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHD--VVACDFS-PDG 122
N S FSP+ + + + LW+ K ++ GH ++ + +FS G
Sbjct: 212 DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGG 271
Query: 123 ALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHV-A 181
+ + S D VYIW+ +I+ + G D + + + + A
Sbjct: 272 KWIVSGSEDNLVYIWNLQTKEIVQKL------------QGHTDVVISTACHPTENIIASA 319
Query: 182 SLADDKMVRFWRID 195
+L +DK ++ W+ D
Sbjct: 320 ALENDKTIKLWKSD 333
Score = 50.8 bits (120), Expect = 1e-06
Identities = 36/136 (26%), Positives = 61/136 (44%), Gaps = 17/136 (12%)
Query: 100 YTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPI 158
Y + L GH V + FSP+G LA++S D + IW ++G GH
Sbjct: 35 YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKL------ 88
Query: 159 FAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTD 216
G +D V++S D + S +DDK ++ W + ++ + CC F+
Sbjct: 89 ---GISD-----VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ 140
Query: 217 GSVLAAGTHDGSVYFW 232
+++ +G+ D SV W
Sbjct: 141 SNLIVSGSFDESVRIW 156
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 101 bits (251), Expect = 8e-22
Identities = 66/224 (29%), Positives = 104/224 (46%), Gaps = 19/224 (8%)
Query: 14 GKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYS 73
GK L H + D+ ++ D S LVSAS DKTL++WD++ G +K L+GH N+V+
Sbjct: 73 GKYEKTLYGHNLEISDVAWSSDSSR-LVSASDDKTLKLWDVRS-GKCLKTLKGHSNYVFC 130
Query: 74 CAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTR 133
C F+P S+++ S + V +W + ++ L H V A F+ G+L+ + SYD
Sbjct: 131 CNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGL 190
Query: 134 VYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWR 193
IWD +G L PP V V FS +G ++ + D ++ W
Sbjct: 191 CRIWDAASGQCLKTLVDDDNPP------------VSFVKFSPNGKYILTATLDNTLKLWD 238
Query: 194 IDEDYPVQV-APLSNGLCCAFS----TDGSVLAAGTHDGSVYFW 232
++ N C F+ T G + +G+ D VY W
Sbjct: 239 YSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW 282
Score = 89.4 bits (220), Expect = 3e-18
Identities = 66/218 (30%), Positives = 100/218 (45%), Gaps = 14/218 (6%)
Query: 16 LLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCA 75
L LV HTE V + F+P+G L S+S D+ + +W D G K L GH + A
Sbjct: 33 LKCTLVGHTEAVSSVKFSPNGEW-LASSSADRLIIIWGAYD-GKYEKTLYGHNLEISDVA 90
Query: 76 FSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVY 135
+S DSS L S K + LW++ ++ L+GH + V C+F+P L+ + S+D V
Sbjct: 91 WSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVK 150
Query: 136 IWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGL-HVASLADDKMVRFWRI 194
IW+ G L L P+ A N VS S+DGL + A + ++
Sbjct: 151 IWEVKTGKCLKT---LSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVD 207
Query: 195 DEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 232
D++ PV FS +G + T D ++ W
Sbjct: 208 DDNPPVSFV--------KFSPNGKYILTATLDNTLKLW 237
Score = 58.5 bits (140), Expect = 6e-09
Identities = 42/138 (30%), Positives = 70/138 (50%), Gaps = 10/138 (7%)
Query: 7 RVNEKEIGKLLLNLVDHTEV-VRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLR 65
R+ + G+ L LVD V + F+P+G IL +A+ D TL++WD G +K
Sbjct: 192 RIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYIL-TATLDNTLKLWDYSR-GRCLKTYT 249
Query: 66 GHQNWVYSCAFSPDS----SMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPD 121
GH+N Y C F+ S + S V++WN+ +++KL+GH V++ P
Sbjct: 250 GHKNEKY-CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPT 308
Query: 122 GALLATASY--DTRVYIW 137
L+A+A+ D + +W
Sbjct: 309 ENLIASAALENDKTIKLW 326
Score = 53.5 bits (127), Expect = 2e-07
Identities = 49/191 (25%), Positives = 82/191 (42%), Gaps = 19/191 (9%)
Query: 7 RVNEKEIGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRG 66
++ E + GK L L H++ V + F GSLI VS S D R+WD G +K L
Sbjct: 150 KIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLI-VSGSYDGLCRIWDAA-SGQCLKTLVD 207
Query: 67 HQNWVYS-CAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHD--VVACDFS-PDG 122
N S FSP+ + + + LW+ + ++ GH ++ + +FS G
Sbjct: 208 DDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGG 267
Query: 123 ALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHV-A 181
+ + S D VYIW+ +I+ + G D + + + L A
Sbjct: 268 KWIVSGSEDNLVYIWNLQTKEIVQKL------------QGHTDVVISAACHPTENLIASA 315
Query: 182 SLADDKMVRFW 192
+L +DK ++ W
Sbjct: 316 ALENDKTIKLW 326
Score = 50.4 bits (119), Expect = 2e-06
Identities = 33/136 (24%), Positives = 61/136 (44%), Gaps = 17/136 (12%)
Query: 100 YTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILME-FGHLFPPPTPI 158
Y + L GH V + FSP+G LA++S D + IW ++G +GH
Sbjct: 31 YALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGH-------- 82
Query: 159 FAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTD 216
+ + V++S D + S +DDK ++ W + ++ + CC F+
Sbjct: 83 ------NLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPP 136
Query: 217 GSVLAAGTHDGSVYFW 232
+++ +G+ D +V W
Sbjct: 137 SNLIISGSFDETVKIW 152
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 88.6 bits (218), Expect = 5e-18
Identities = 54/174 (31%), Positives = 84/174 (48%), Gaps = 17/174 (9%)
Query: 20 LVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPD 79
L H V + F P S ++VSAS D T++VWD + G+ + L+GH + V +F
Sbjct: 104 LSGHRSPVTRVIFHPVFS-VMVSASEDATIKVWDY-ETGDFERTLKGHTDSVQDISFDHS 161
Query: 80 SSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDP 139
+L S A + LW+ + IR + GH H+V + P+G + +AS D + +W+
Sbjct: 162 GKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEV 221
Query: 140 HNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW 192
G + F GH WVR V + DG +AS ++D+ VR W
Sbjct: 222 QTGYCVKTFTGH--------------REWVRMVRPNQDGTLIASCSNDQTVRVW 261
Score = 76.3 bits (186), Expect = 3e-14
Identities = 54/191 (28%), Positives = 80/191 (41%), Gaps = 37/191 (19%)
Query: 23 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 82
H V + P+G I VSASRDKT+++W+++ G +K GH+ WV + D ++
Sbjct: 191 HDHNVSSVAIMPNGDHI-VSASRDKTIKMWEVQT-GYCVKTFTGHREWVRMVRPNQDGTL 248
Query: 83 LCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPD--------------------G 122
+ S + V +W + +L H H V ++P+ G
Sbjct: 249 IASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPG 308
Query: 123 ALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVA 181
L + S D + +WD G LM GH D WVR V F G +
Sbjct: 309 PFLLSGSRDKTIKMWDVSTGMCLMTLVGH--------------DNWVRGVLFHSGGKFIL 354
Query: 182 SLADDKMVRFW 192
S ADDK +R W
Sbjct: 355 SCADDKTLRVW 365
Score = 66.6 bits (161), Expect = 2e-11
Identities = 38/138 (27%), Positives = 59/138 (42%), Gaps = 20/138 (14%)
Query: 20 LVDHTEVVRDLTFAPDGSL-------------------ILVSASRDKTLRVWDLKDDGNM 60
L +H VV +++AP+ S L+S SRDKT+++WD+ G
Sbjct: 272 LREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVST-GMC 330
Query: 61 MKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSP 120
+ L GH NWV F + S K + +W+ ++ L H H V + DF
Sbjct: 331 LMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHK 390
Query: 121 DGALLATASYDTRVYIWD 138
+ T S D V +W+
Sbjct: 391 TAPYVVTGSVDQTVKVWE 408
Score = 59.3 bits (142), Expect = 4e-09
Identities = 43/172 (25%), Positives = 73/172 (42%), Gaps = 17/172 (9%)
Query: 64 LRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGA 123
L GH++ V F P S++ S + +W+ + R L+GH V F G
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGK 163
Query: 124 LLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVAS 182
LLA+ S D + +WD + + GH D V SV+ +G H+ S
Sbjct: 164 LLASCSADMTIKLWDFQGFECIRTMHGH--------------DHNVSSVAIMPNGDHIVS 209
Query: 183 LADDKMVRFWRIDEDYPVQVAPLSNGLCCAF--STDGSVLAAGTHDGSVYFW 232
+ DK ++ W + Y V+ + DG+++A+ ++D +V W
Sbjct: 210 ASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW 261
Score = 48.1 bits (113), Expect = 8e-06
Identities = 46/203 (22%), Positives = 80/203 (39%), Gaps = 35/203 (17%)
Query: 10 EKEIGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQN 69
E + G + H E VR + DG+LI S S D+T+RVW + LR H++
Sbjct: 220 EVQTGYCVKTFTGHREWVRMVRPNQDGTLI-ASCSNDQTVRVWVVATK-ECKAELREHEH 277
Query: 70 WVYSCAFSPDSS--------------------MLCSVGASKAVFLWNMDKYTMIRKLEGH 109
V +++P+SS L S K + +W++ + L GH
Sbjct: 278 VVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGH 337
Query: 110 HHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVR 169
+ V F G + + + D + +WD N + A++ +V
Sbjct: 338 DNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTL-------------NAHEHFVT 384
Query: 170 SVSFSHDGLHVASLADDKMVRFW 192
S+ F +V + + D+ V+ W
Sbjct: 385 SLDFHKTAPYVVTGSVDQTVKVW 407
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 86.7 bits (213), Expect = 2e-17
Identities = 60/212 (28%), Positives = 92/212 (43%), Gaps = 17/212 (8%)
Query: 23 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 82
H + L +P+G L +AS D L +W+ K + + GH++ V S FSP ++
Sbjct: 17 HKAAITSLDLSPNGKQ-LATASWDTFLMLWNFKPHARAYRYV-GHKDVVTSVQFSPHGNL 74
Query: 83 LCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNG 142
L S + V LW DK + + H V + DFS DG LATAS D + +W +
Sbjct: 75 LASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQ 134
Query: 143 DILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQV 202
L ++ + WVR FS DG + S ++DK ++ W V
Sbjct: 135 RFL-------------YSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN 181
Query: 203 APLSNGLC--CAFSTDGSVLAAGTHDGSVYFW 232
S G F+ G+ +A+ D +V W
Sbjct: 182 FSDSVGFANFVDFNPSGTCIASAGSDQTVKVW 213
Score = 85.9 bits (211), Expect = 4e-17
Identities = 67/263 (25%), Positives = 108/263 (41%), Gaps = 33/263 (12%)
Query: 21 VDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDS 80
V H +VV + F+P G+L L SASRD+T+R+W + D + H V S FS D
Sbjct: 57 VGHKDVVTSVQFSPHGNL-LASASRDRTVRLW-IPDKRGKFSEFKAHTAPVRSVDFSADG 114
Query: 81 SMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPH 140
L + K++ +W+M + + L H H V FSPDG L+ + S D + IWD
Sbjct: 115 QFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTT 174
Query: 141 NGDILMEFGHL--------FPPPTPIFAGGANDRWVR---------------------SV 171
N + F F P A +D+ V+ +
Sbjct: 175 NKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCI 234
Query: 172 SFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSV 229
SF G ++ + + D ++ + E + G +FS G + A+G D V
Sbjct: 235 SFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQV 294
Query: 230 YFWATPRQVPSLQHLCRMSIRRV 252
W T + L + +++R+
Sbjct: 295 LLWRTNFDELHCKGLTKRNLKRL 317
Score = 76.3 bits (186), Expect = 3e-14
Identities = 51/182 (28%), Positives = 84/182 (46%), Gaps = 17/182 (9%)
Query: 56 DDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVA 115
+D + + +GH+ + S SP+ L + + LWN + + GH V +
Sbjct: 6 EDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTS 65
Query: 116 CDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFS 174
FSP G LLA+AS D V +W P EF H P VRSV FS
Sbjct: 66 VQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAP--------------VRSVDFS 111
Query: 175 HDGLHVASLADDKMVRFWRI-DEDYPVQVAPLSNGLCCA-FSTDGSVLAAGTHDGSVYFW 232
DG +A+ ++DK ++ W + + + + ++ + CA FS DG ++ + + D ++ W
Sbjct: 112 ADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIW 171
Query: 233 AT 234
T
Sbjct: 172 DT 173
Score = 73.9 bits (180), Expect = 1e-13
Identities = 60/186 (32%), Positives = 84/186 (45%), Gaps = 21/186 (11%)
Query: 15 KLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDL--KDDGNMMKVLRGHQNWVY 72
+ L +L HT VR F+PDG LI VS S DKT+++WD K N G N+V
Sbjct: 135 RFLYSLYRHTHWVRCAKFSPDGRLI-VSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFV- 192
Query: 73 SCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDT 132
F+P + + S G+ + V +W++ +++ + H V F P G L TAS D
Sbjct: 193 --DFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDG 250
Query: 133 RVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRF 191
+ I D G ++ GH P V +VSFS G AS D V
Sbjct: 251 TLKILDLLEGRLIYTLQGHTGP--------------VFTVSFSKGGELFASGGADTQVLL 296
Query: 192 WRIDED 197
WR + D
Sbjct: 297 WRTNFD 302
Score = 61.6 bits (148), Expect = 7e-10
Identities = 43/139 (30%), Positives = 64/139 (46%), Gaps = 21/139 (15%)
Query: 104 RKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGA 163
R +GH + + D SP+G LATAS+DT + +W+ F P +
Sbjct: 12 RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWN-------------FKPHARAYRYVG 58
Query: 164 NDRWVRSVSFSHDGLHVASLADDKMVRFWRIDE-----DYPVQVAPLSNGLCCAFSTDGS 218
+ V SV FS G +AS + D+ VR W D+ ++ AP+ + FS DG
Sbjct: 59 HKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRS---VDFSADGQ 115
Query: 219 VLAAGTHDGSVYFWATPRQ 237
LA + D S+ W+ RQ
Sbjct: 116 FLATASEDKSIKVWSMYRQ 134
Score = 50.8 bits (120), Expect = 1e-06
Identities = 30/89 (33%), Positives = 50/89 (56%), Gaps = 2/89 (2%)
Query: 7 RVNEKEIGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRG 66
+V + + KLL + H+ V ++F P G+ L++AS D TL++ DL +G ++ L+G
Sbjct: 211 KVWDVRVNKLLQHYQVHSGGVNCISFHPSGN-YLITASSDGTLKILDLL-EGRLIYTLQG 268
Query: 67 HQNWVYSCAFSPDSSMLCSVGASKAVFLW 95
H V++ +FS + S GA V LW
Sbjct: 269 HTGPVFTVSFSKGGELFASGGADTQVLLW 297
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 84.0 bits (206), Expect = 1e-16
Identities = 69/236 (29%), Positives = 105/236 (44%), Gaps = 22/236 (9%)
Query: 7 RVNEKEIGK--LLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVL 64
RVN I K +++L HT V + LI V+ S+ ++RVWDL + +++ L
Sbjct: 44 RVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELI-VAGSQSGSIRVWDL-EAAKILRTL 101
Query: 65 RGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGAL 124
GH+ + S F P + S + LW++ + + + GH V FSPDG
Sbjct: 102 MGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKW 161
Query: 125 LATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASL 183
LA+A+ D V +WD G ++ EF GH P V V F + +AS
Sbjct: 162 LASAADDHTVKLWDLTAGKMMSEFPGHTGP--------------VNVVEFHPNEYLLASG 207
Query: 184 ADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTHDG-SVYFWATPR 236
+ D+ +RFW +++ V G F+ DG L +G D VY W R
Sbjct: 208 SSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEPER 263
Score = 52.0 bits (123), Expect = 6e-07
Identities = 51/201 (25%), Positives = 77/201 (38%), Gaps = 38/201 (18%)
Query: 67 HQNWVYSCAFSPDSSMLCSVGASKA-VFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALL 125
H + V S S L + G V LW+++K I L GH V + + L+
Sbjct: 19 HASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELI 78
Query: 126 ATASYDTRVYIWDPHNGDILME-FGHL-------FPPPTPIFAGGANDR----W------ 167
S + +WD IL GH F P A G+ D W
Sbjct: 79 VAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKG 138
Query: 168 -----------VRSVSFSHDGLHVASLADDKMVRFW-----RIDEDYPVQVAPLSNGLCC 211
VR + FS DG +AS ADD V+ W ++ ++P P++
Sbjct: 139 CVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVN---VV 195
Query: 212 AFSTDGSVLAAGTHDGSVYFW 232
F + +LA+G+ D ++ FW
Sbjct: 196 EFHPNEYLLASGSSDRTIRFW 216
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 84.0 bits (206), Expect = 1e-16
Identities = 43/119 (36%), Positives = 68/119 (57%), Gaps = 2/119 (1%)
Query: 23 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 82
H V + F P+ + L + S DKT+R+W + GN +++ GH+ V S AFSP+
Sbjct: 425 HLADVDCVKFHPNSNY-LATGSTDKTVRLWSAQQ-GNSVRLFTGHRGPVLSLAFSPNGKY 482
Query: 83 LCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHN 141
L S G + + LW++ T+ ++L GH ++ + FSPD L+A+AS D V +WD N
Sbjct: 483 LASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRN 541
Score = 79.7 bits (195), Expect = 3e-15
Identities = 56/176 (31%), Positives = 81/176 (46%), Gaps = 15/176 (8%)
Query: 23 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 82
H V DL +P SL S S D+T R+W D +++ GH V F P+S+
Sbjct: 383 HAYPVWDLDISPY-SLYFASGSHDRTARLWSF-DRTYPLRIYAGHLADVDCVKFHPNSNY 440
Query: 83 LCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNG 142
L + K V LW+ + +R GH V++ FSP+G LA+A D R+ +WD +G
Sbjct: 441 LATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASG 500
Query: 143 DILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDY 198
+ E G D + S++FS D +AS + D VR W I Y
Sbjct: 501 TLYKEL------------RGHTDN-ITSLTFSPDSGLIASASMDNSVRVWDIRNTY 543
Score = 74.7 bits (182), Expect = 8e-14
Identities = 59/213 (27%), Positives = 90/213 (42%), Gaps = 33/213 (15%)
Query: 53 DLKDD--GNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHH 110
D +DD G MK+LRGH VYS F DSS L S ++ W++ +T +GH
Sbjct: 325 DDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHA 384
Query: 111 HDVVACDFSPDGALLATASYDTRVYIWD-PHNGDILMEFGHL-------FPPPTPIFAGG 162
+ V D SP A+ S+D +W + + GHL F P + A G
Sbjct: 385 YPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATG 444
Query: 163 ANDRWVR---------------------SVSFSHDGLHVASLADDKMVRFWRIDED--YP 199
+ D+ VR S++FS +G ++AS +D+ ++ W + Y
Sbjct: 445 STDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYK 504
Query: 200 VQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 232
N FS D ++A+ + D SV W
Sbjct: 505 ELRGHTDNITSLTFSPDSGLIASASMDNSVRVW 537
Score = 41.2 bits (95), Expect = 0.001
Identities = 20/43 (46%), Positives = 28/43 (65%), Gaps = 1/43 (2%)
Query: 14 GKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKD 56
G L L HT+ + LTF+PD LI SAS D ++RVWD+++
Sbjct: 500 GTLYKELRGHTDNITSLTFSPDSGLI-ASASMDNSVRVWDIRN 541
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 82.0 bits (201), Expect = 5e-16
Identities = 73/269 (27%), Positives = 114/269 (42%), Gaps = 42/269 (15%)
Query: 5 PPRVNEKEIGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVL 64
PPR + + +LL+ H V F P+GS L SA D+ + +W++ D + L
Sbjct: 49 PPRCSSLQAPIMLLS--GHEGEVYCCKFHPNGST-LASAGFDRLILLWNVYGDCDNYATL 105
Query: 65 RGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGA- 123
+GH V ++ D SML S K V +W+ + +++L+GH V +C + G
Sbjct: 106 KGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQ 165
Query: 124 LLATASYDTRVYIWDPHNGDILMEFGHLFP--------PPTPIFAGGANDR---W----- 167
L+ T S D V +WD + F + + I +GG ++ W
Sbjct: 166 LVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQN 225
Query: 168 ------------VRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPL---------- 205
V +S S +G ++ S A D VR W + P +
Sbjct: 226 KLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFE 285
Query: 206 SNGLCCAFSTDGSVLAAGTHDGSVYFWAT 234
N L C++S DGS +AAG+ D VY W T
Sbjct: 286 KNLLRCSWSPDGSKIAAGSADRFVYVWDT 314
Score = 65.1 bits (157), Expect = 6e-11
Identities = 37/129 (28%), Positives = 68/129 (52%), Gaps = 8/129 (6%)
Query: 15 KLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYS- 73
KL + H + V L+ + +GS +L +A D T+RVWD++ + ++ Q V++
Sbjct: 226 KLTYTMRGHADSVTGLSLSSEGSYLLSNAM-DNTVRVWDVRPFAPKERCVKIFQGNVHNF 284
Query: 74 ------CAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLAT 127
C++SPD S + + A + V++W+ ++ KL GH + F PD ++ +
Sbjct: 285 EKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIIS 344
Query: 128 ASYDTRVYI 136
AS D R+Y+
Sbjct: 345 ASSDKRLYM 353
Score = 60.1 bits (144), Expect = 2e-09
Identities = 61/263 (23%), Positives = 101/263 (38%), Gaps = 67/263 (25%)
Query: 20 LVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSC----- 74
L H+ V +L + DGS+ L SAS DKT+ VWD + G +K L+GH ++V SC
Sbjct: 105 LKGHSGAVMELHYNTDGSM-LFSASTDKTVAVWD-SETGERVKRLKGHTSFVNSCYPARR 162
Query: 75 -------------------------------------AFSPDSSMLCSVGASKAVFLWNM 97
F+ S + S G + +W++
Sbjct: 163 GPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDL 222
Query: 98 DKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPP-- 155
+ + + GH V S +G+ L + + D V +WD F P
Sbjct: 223 RQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRP----------FAPKER 272
Query: 156 -TPIFAGGAN--DRWVRSVSFSHDGLHVASLADDKMVRFW-----RIDEDYPVQVAPLSN 207
IF G + ++ + S+S DG +A+ + D+ V W RI P ++
Sbjct: 273 CVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINE 332
Query: 208 GLCCAFSTDGSVLAAGTHDGSVY 230
AF D ++ + + D +Y
Sbjct: 333 ---VAFHPDEPIIISASSDKRLY 352
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 81.3 bits (199), Expect = 9e-16
Identities = 70/237 (29%), Positives = 102/237 (43%), Gaps = 33/237 (13%)
Query: 27 VRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSV 86
+R + A D SLI S D R+ D K + +K+L GH VY +FSPD + L S
Sbjct: 504 LRSVKQASDLSLI-DKESDDVLERIMDEKT-ASELKILYGHSGPVYGASFSPDRNYLLSS 561
Query: 87 GASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIW-DPHNGDIL 145
V LW++ +T + +GH++ V FSP G + +D +W H +
Sbjct: 562 SEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLR 621
Query: 146 MEFGHL-------FPPPTPIFAGGANDRWVR---------------------SVSFSHDG 177
+ GHL F P + A G+ DR VR S++FS +G
Sbjct: 622 IFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNG 681
Query: 178 LHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCCA--FSTDGSVLAAGTHDGSVYFW 232
+A+ A D V W I V C+ FS DG +LA+G+ D +V W
Sbjct: 682 RFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
Score = 74.7 bits (182), Expect = 8e-14
Identities = 38/116 (32%), Positives = 64/116 (55%), Gaps = 2/116 (1%)
Query: 23 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 82
H V F P+ + + + S D+T+R+WD+ + GN +++ GH+ ++S FSP+
Sbjct: 626 HLADVNCTRFHPNSNYV-ATGSADRTVRLWDVLN-GNCVRIFTGHKGPIHSLTFSPNGRF 683
Query: 83 LCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWD 138
L + V LW++ M+ +L+GH V + FS DG +LA+ S D V +WD
Sbjct: 684 LATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
Score = 43.9 bits (102), Expect = 2e-04
Identities = 26/77 (33%), Positives = 39/77 (50%), Gaps = 2/77 (2%)
Query: 23 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 82
H + LTF+P+G + A+ + L +WD+ G M+ L+GH + V S FS D +
Sbjct: 668 HKGPIHSLTFSPNGRFLATGATDGRVL-LWDI-GHGLMVGELKGHTDTVCSLRFSRDGEI 725
Query: 83 LCSVGASKAVFLWNMDK 99
L S V LW+ K
Sbjct: 726 LASGSMDNTVRLWDAIK 742
Score = 34.7 bits (78), Expect = 0.093
Identities = 18/40 (45%), Positives = 24/40 (60%), Gaps = 1/40 (2%)
Query: 14 GKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWD 53
G ++ L HT+ V L F+ DG IL S S D T+R+WD
Sbjct: 701 GLMVGELKGHTDTVCSLRFSRDGE-ILASGSMDNTVRLWD 739
Score = 30.8 bits (68), Expect = 1.3
Identities = 39/170 (22%), Positives = 57/170 (33%), Gaps = 44/170 (25%)
Query: 100 YTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIW-------------------DPH 140
YT + +G + A D + D +L+A D+ V +W D
Sbjct: 464 YTFLNAYQG----LTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKE 519
Query: 141 NGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRID---- 195
+ D+L I G + V SFS D ++ S ++D VR W +
Sbjct: 520 SDDVLERIMDEKTASELKILYGHSGP--VYGASFSPDRNYLLSSSEDGTVRLWSLQTFTC 577
Query: 196 ------EDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQVP 239
+YPV FS G +G HD WAT P
Sbjct: 578 LVGYKGHNYPVWDTQ--------FSPYGYYFVSGGHDRVARLWATDHYQP 619
>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
sapiens]
Length = 472
Score = 81.3 bits (199), Expect = 9e-16
Identities = 45/180 (25%), Positives = 81/180 (45%), Gaps = 20/180 (11%)
Query: 23 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 82
HT + F PD + S S D+ +++WD+ ++ + + H N + +C F+
Sbjct: 229 HTRSITSCCFDPDSQRV-ASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHF 287
Query: 83 LCSVGASKAVFLWNM------DKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYI 136
LC+ K + +WN+ + + ++GH V +C F+ D + L + +D V I
Sbjct: 288 LCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAI 347
Query: 137 WDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDE 196
WD G + G ND WV V+ S++ + S + D+ +R W I+E
Sbjct: 348 WDVAEG------------YRKLSLKGHND-WVMDVAISNNKKWILSASKDRTMRLWNIEE 394
Score = 68.2 bits (165), Expect = 8e-12
Identities = 56/233 (24%), Positives = 94/233 (40%), Gaps = 46/233 (19%)
Query: 26 VVRDLTFAPDGSLI----------LVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCA 75
VVRD P ++ +++AS DKT+R WDL+ + KV + ++ SC
Sbjct: 136 VVRDFEHRPKAPVVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKV--RYDTFIVSCK 193
Query: 76 FSPDSSMLCS-VGASKAVFLWNMDKYTMIRKLEGHH-HDVVACDFSPDGALLATASYDTR 133
FSPD + S + + + + T + ++ HH + +C F PD +A+ S D
Sbjct: 194 FSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRC 253
Query: 134 VYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWR 193
+ IWD + L+ A+ + + F+ G + + + DK ++ W
Sbjct: 254 IKIWDVTSQATLLTITK------------AHSNAISNCCFTFSGHFLCTSSWDKNLKIWN 301
Query: 194 IDEDYPVQVAPLSN-GLC-------------CAFSTDGSVLAAGTHDGSVYFW 232
V N G C C F+ D S L +G D +V W
Sbjct: 302 ------VHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIW 348
Score = 55.8 bits (133), Expect = 4e-08
Identities = 36/119 (30%), Positives = 54/119 (45%), Gaps = 13/119 (10%)
Query: 106 LEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGAND 165
L GH H V C F D L + SYD V +WDP +G ++ +F H P P+
Sbjct: 98 LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEH--RPKAPVV------ 149
Query: 166 RWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPV-QVAPLSNGLCCAFSTDGSVLAAG 223
S + D V + + DK VR W ++ + +V + + C FS DG + +G
Sbjct: 150 ----ECSITGDSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSG 204
Score = 54.3 bits (129), Expect = 1e-07
Identities = 49/205 (23%), Positives = 78/205 (38%), Gaps = 34/205 (16%)
Query: 62 KVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH-HHDVVACDFSP 120
K+L GH++ V +C F D + L S V LW+ +++R E VV C +
Sbjct: 96 KILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITG 155
Query: 121 DGALLATASYDTRVYIWDPHNGDILMEFGH-------LFPPPTPIFAGG----------- 162
D + + ASYD V WD G +L + + F P G
Sbjct: 156 DSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMD 215
Query: 163 ---------ANDRWVRSVS---FSHDGLHVASLADDKMVRFWRIDEDYPVQVAPL--SNG 208
D RS++ F D VAS++ D+ ++ W + + SN
Sbjct: 216 AENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNA 275
Query: 209 LC-CAFSTDGSVLAAGTHDGSVYFW 232
+ C F+ G L + D ++ W
Sbjct: 276 ISNCCFTFSGHFLCTSSWDKNLKIW 300
Score = 30.8 bits (68), Expect = 1.3
Identities = 15/48 (31%), Positives = 31/48 (64%), Gaps = 1/48 (2%)
Query: 18 LNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLR 65
L+L H + V D+ + + IL SAS+D+T+R+W++++ + V++
Sbjct: 357 LSLKGHNDWVMDVAISNNKKWIL-SASKDRTMRLWNIEEIDEIPLVIK 403
>gi|189571685 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
Length = 476
Score = 78.6 bits (192), Expect = 6e-15
Identities = 68/225 (30%), Positives = 96/225 (42%), Gaps = 22/225 (9%)
Query: 23 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNW-VYSCAFSPDSS 81
HT V F+P G IL S S D T +W+ ++G M+ V+ V C FSPDS+
Sbjct: 53 HTYAVHCCCFSPSGH-ILASCSTDGTTVLWNT-ENGQMLAVMEQPSGSPVRVCQFSPDST 110
Query: 82 MLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHN 141
L S A V LWN Y + R + AC FSP+G+ T S + +WD
Sbjct: 111 CLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM 170
Query: 142 GDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGL---HVASLADDKMVRFWRID--- 195
+ E H F+ + VS GL +AS D V+ W +
Sbjct: 171 RCLHSEKAHDLGITCCDFSS-------QPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTH 223
Query: 196 -EDYPVQVAPLSNGLC-----CAFSTDGSVLAAGTHDGSVYFWAT 234
+ ++ +G C CAFS DG +L +G+ D SV + T
Sbjct: 224 ILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDT 268
Score = 63.9 bits (154), Expect = 1e-10
Identities = 51/177 (28%), Positives = 77/177 (43%), Gaps = 18/177 (10%)
Query: 60 MMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMI--RKLEGHHHDVVACD 117
++ L H + V CAFS S+L + K + L+++ +T + L+ H + V C
Sbjct: 4 LIHTLADHGDDVNCCAFS--FSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCC 61
Query: 118 FSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDG 177
FSP G +LA+ S D +W+ NG +L P +P VR FS D
Sbjct: 62 FSPSGHILASCSTDGTTVLWNTENGQMLAVMEQ--PSGSP----------VRVCQFSPDS 109
Query: 178 LHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSVYFW 232
+AS A D V W + + +G CAFS +GS G+ G + W
Sbjct: 110 TCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVW 166
Score = 55.5 bits (132), Expect = 5e-08
Identities = 34/104 (32%), Positives = 49/104 (47%), Gaps = 6/104 (5%)
Query: 40 LVSASRDKTLRVWD------LKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVF 93
L S +D +++W L + L GH V +CAFS D ML S K+V
Sbjct: 205 LASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVI 264
Query: 94 LWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIW 137
+++ + ++ L H V C F+P+ LLAT S D V IW
Sbjct: 265 VYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
Score = 50.8 bits (120), Expect = 1e-06
Identities = 53/182 (29%), Positives = 78/182 (42%), Gaps = 35/182 (19%)
Query: 32 FAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFS--PDSS-------- 81
F+P+GS V+ S L VWD D + + H + C FS P S
Sbjct: 147 FSPNGSFF-VTGSSCGDLTVWD--DKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFF 203
Query: 82 MLCSVGASKAVFLWNMDKYTMI--------RKLEGHHHDVVACDFSPDGALLATASYDTR 133
L S G V +W + +T I L GH V+AC FS DG +L + S D
Sbjct: 204 RLASCGQDCQVKIWIVS-FTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKS 262
Query: 134 VYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWR 193
V ++D + +IL H T R+V + +F+ + L +A+ + DK V W+
Sbjct: 263 VIVYDTNTENIL----HTLTQHT---------RYVTTCAFAPNTLLLATGSMDKTVNIWQ 309
Query: 194 ID 195
D
Sbjct: 310 FD 311
Score = 49.3 bits (116), Expect = 4e-06
Identities = 29/91 (31%), Positives = 47/91 (51%), Gaps = 2/91 (2%)
Query: 20 LVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPD 79
L H V F+ DG + LVS S DK++ V+D + N++ L H +V +CAF+P+
Sbjct: 235 LSGHCAPVLACAFSHDGQM-LVSGSVDKSVIVYDTNTE-NILHTLTQHTRYVTTCAFAPN 292
Query: 80 SSMLCSVGASKAVFLWNMDKYTMIRKLEGHH 110
+ +L + K V +W D T+ + H
Sbjct: 293 TLLLATGSMDKTVNIWQFDLETLCQARRTEH 323
>gi|189571683 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
Length = 476
Score = 78.6 bits (192), Expect = 6e-15
Identities = 68/225 (30%), Positives = 96/225 (42%), Gaps = 22/225 (9%)
Query: 23 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNW-VYSCAFSPDSS 81
HT V F+P G IL S S D T +W+ ++G M+ V+ V C FSPDS+
Sbjct: 53 HTYAVHCCCFSPSGH-ILASCSTDGTTVLWNT-ENGQMLAVMEQPSGSPVRVCQFSPDST 110
Query: 82 MLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHN 141
L S A V LWN Y + R + AC FSP+G+ T S + +WD
Sbjct: 111 CLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM 170
Query: 142 GDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGL---HVASLADDKMVRFWRID--- 195
+ E H F+ + VS GL +AS D V+ W +
Sbjct: 171 RCLHSEKAHDLGITCCDFSS-------QPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTH 223
Query: 196 -EDYPVQVAPLSNGLC-----CAFSTDGSVLAAGTHDGSVYFWAT 234
+ ++ +G C CAFS DG +L +G+ D SV + T
Sbjct: 224 ILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDT 268
Score = 63.9 bits (154), Expect = 1e-10
Identities = 51/177 (28%), Positives = 77/177 (43%), Gaps = 18/177 (10%)
Query: 60 MMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMI--RKLEGHHHDVVACD 117
++ L H + V CAFS S+L + K + L+++ +T + L+ H + V C
Sbjct: 4 LIHTLADHGDDVNCCAFS--FSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCC 61
Query: 118 FSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDG 177
FSP G +LA+ S D +W+ NG +L P +P VR FS D
Sbjct: 62 FSPSGHILASCSTDGTTVLWNTENGQMLAVMEQ--PSGSP----------VRVCQFSPDS 109
Query: 178 LHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSVYFW 232
+AS A D V W + + +G CAFS +GS G+ G + W
Sbjct: 110 TCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVW 166
Score = 55.5 bits (132), Expect = 5e-08
Identities = 34/104 (32%), Positives = 49/104 (47%), Gaps = 6/104 (5%)
Query: 40 LVSASRDKTLRVWD------LKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVF 93
L S +D +++W L + L GH V +CAFS D ML S K+V
Sbjct: 205 LASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVI 264
Query: 94 LWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIW 137
+++ + ++ L H V C F+P+ LLAT S D V IW
Sbjct: 265 VYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
Score = 50.8 bits (120), Expect = 1e-06
Identities = 53/182 (29%), Positives = 78/182 (42%), Gaps = 35/182 (19%)
Query: 32 FAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFS--PDSS-------- 81
F+P+GS V+ S L VWD D + + H + C FS P S
Sbjct: 147 FSPNGSFF-VTGSSCGDLTVWD--DKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFF 203
Query: 82 MLCSVGASKAVFLWNMDKYTMI--------RKLEGHHHDVVACDFSPDGALLATASYDTR 133
L S G V +W + +T I L GH V+AC FS DG +L + S D
Sbjct: 204 RLASCGQDCQVKIWIVS-FTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKS 262
Query: 134 VYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWR 193
V ++D + +IL H T R+V + +F+ + L +A+ + DK V W+
Sbjct: 263 VIVYDTNTENIL----HTLTQHT---------RYVTTCAFAPNTLLLATGSMDKTVNIWQ 309
Query: 194 ID 195
D
Sbjct: 310 FD 311
Score = 49.3 bits (116), Expect = 4e-06
Identities = 29/91 (31%), Positives = 47/91 (51%), Gaps = 2/91 (2%)
Query: 20 LVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPD 79
L H V F+ DG + LVS S DK++ V+D + N++ L H +V +CAF+P+
Sbjct: 235 LSGHCAPVLACAFSHDGQM-LVSGSVDKSVIVYDTNTE-NILHTLTQHTRYVTTCAFAPN 292
Query: 80 SSMLCSVGASKAVFLWNMDKYTMIRKLEGHH 110
+ +L + K V +W D T+ + H
Sbjct: 293 TLLLATGSMDKTVNIWQFDLETLCQARRTEH 323
>gi|189571681 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
Length = 476
Score = 78.6 bits (192), Expect = 6e-15
Identities = 68/225 (30%), Positives = 96/225 (42%), Gaps = 22/225 (9%)
Query: 23 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNW-VYSCAFSPDSS 81
HT V F+P G IL S S D T +W+ ++G M+ V+ V C FSPDS+
Sbjct: 53 HTYAVHCCCFSPSGH-ILASCSTDGTTVLWNT-ENGQMLAVMEQPSGSPVRVCQFSPDST 110
Query: 82 MLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHN 141
L S A V LWN Y + R + AC FSP+G+ T S + +WD
Sbjct: 111 CLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM 170
Query: 142 GDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGL---HVASLADDKMVRFWRID--- 195
+ E H F+ + VS GL +AS D V+ W +
Sbjct: 171 RCLHSEKAHDLGITCCDFSS-------QPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTH 223
Query: 196 -EDYPVQVAPLSNGLC-----CAFSTDGSVLAAGTHDGSVYFWAT 234
+ ++ +G C CAFS DG +L +G+ D SV + T
Sbjct: 224 ILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDT 268
Score = 63.9 bits (154), Expect = 1e-10
Identities = 51/177 (28%), Positives = 77/177 (43%), Gaps = 18/177 (10%)
Query: 60 MMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMI--RKLEGHHHDVVACD 117
++ L H + V CAFS S+L + K + L+++ +T + L+ H + V C
Sbjct: 4 LIHTLADHGDDVNCCAFS--FSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCC 61
Query: 118 FSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDG 177
FSP G +LA+ S D +W+ NG +L P +P VR FS D
Sbjct: 62 FSPSGHILASCSTDGTTVLWNTENGQMLAVMEQ--PSGSP----------VRVCQFSPDS 109
Query: 178 LHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSVYFW 232
+AS A D V W + + +G CAFS +GS G+ G + W
Sbjct: 110 TCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVW 166
Score = 55.5 bits (132), Expect = 5e-08
Identities = 34/104 (32%), Positives = 49/104 (47%), Gaps = 6/104 (5%)
Query: 40 LVSASRDKTLRVWD------LKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVF 93
L S +D +++W L + L GH V +CAFS D ML S K+V
Sbjct: 205 LASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVI 264
Query: 94 LWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIW 137
+++ + ++ L H V C F+P+ LLAT S D V IW
Sbjct: 265 VYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
Score = 50.8 bits (120), Expect = 1e-06
Identities = 53/182 (29%), Positives = 78/182 (42%), Gaps = 35/182 (19%)
Query: 32 FAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFS--PDSS-------- 81
F+P+GS V+ S L VWD D + + H + C FS P S
Sbjct: 147 FSPNGSFF-VTGSSCGDLTVWD--DKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFF 203
Query: 82 MLCSVGASKAVFLWNMDKYTMI--------RKLEGHHHDVVACDFSPDGALLATASYDTR 133
L S G V +W + +T I L GH V+AC FS DG +L + S D
Sbjct: 204 RLASCGQDCQVKIWIVS-FTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKS 262
Query: 134 VYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWR 193
V ++D + +IL H T R+V + +F+ + L +A+ + DK V W+
Sbjct: 263 VIVYDTNTENIL----HTLTQHT---------RYVTTCAFAPNTLLLATGSMDKTVNIWQ 309
Query: 194 ID 195
D
Sbjct: 310 FD 311
Score = 49.3 bits (116), Expect = 4e-06
Identities = 29/91 (31%), Positives = 47/91 (51%), Gaps = 2/91 (2%)
Query: 20 LVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPD 79
L H V F+ DG + LVS S DK++ V+D + N++ L H +V +CAF+P+
Sbjct: 235 LSGHCAPVLACAFSHDGQM-LVSGSVDKSVIVYDTNTE-NILHTLTQHTRYVTTCAFAPN 292
Query: 80 SSMLCSVGASKAVFLWNMDKYTMIRKLEGHH 110
+ +L + K V +W D T+ + H
Sbjct: 293 TLLLATGSMDKTVNIWQFDLETLCQARRTEH 323
>gi|62234438 Notchless gene homolog isoform b [Homo sapiens]
Length = 193
Score = 77.4 bits (189), Expect = 1e-14
Identities = 43/123 (34%), Positives = 68/123 (55%), Gaps = 2/123 (1%)
Query: 15 KLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSC 74
K L + H ++ + F+PD S I+ SAS DK++++WD + G + LRGH VY
Sbjct: 71 KPLTRMTGHQALINQVLFSPD-SRIVASASFDKSIKLWDGR-TGKYLASLRGHVAAVYQI 128
Query: 75 AFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRV 134
A+S DS +L S + + +W++ + L GH +V A D+SPDG +A+ D +
Sbjct: 129 AWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCL 188
Query: 135 YIW 137
IW
Sbjct: 189 RIW 191
Score = 73.6 bits (179), Expect = 2e-13
Identities = 49/154 (31%), Positives = 72/154 (46%), Gaps = 13/154 (8%)
Query: 40 LVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDK 99
LVS S D TL +W +D + + GHQ + FSPDS ++ S K++ LW+
Sbjct: 52 LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRT 111
Query: 100 YTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIF 159
+ L GH V +S D LL + S D+ + +WD + M+
Sbjct: 112 GKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMD-----------L 160
Query: 160 AGGANDRWVRSVSFSHDGLHVASLADDKMVRFWR 193
G A++ V +V +S DG VAS DK +R WR
Sbjct: 161 PGHADE--VYAVDWSPDGQRVASGGKDKCLRIWR 192
Score = 54.3 bits (129), Expect = 1e-07
Identities = 32/82 (39%), Positives = 45/82 (54%), Gaps = 2/82 (2%)
Query: 14 GKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYS 73
GK L +L H V + ++ D S +LVS S D TL+VWD+K M L GH + VY+
Sbjct: 112 GKYLASLRGHVAAVYQIAWSAD-SRLLVSGSSDSTLKVWDVKAQKLAMD-LPGHADEVYA 169
Query: 74 CAFSPDSSMLCSVGASKAVFLW 95
+SPD + S G K + +W
Sbjct: 170 VDWSPDGQRVASGGKDKCLRIW 191
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 77.0 bits (188), Expect = 2e-14
Identities = 54/172 (31%), Positives = 81/172 (47%), Gaps = 10/172 (5%)
Query: 23 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 82
H E V+D + L+ S S D T++VW++ GN K HQ V SC S D++
Sbjct: 1000 HQETVKDFRLLKNSRLL--SWSFDGTVKVWNIIT-GNKEKDFVCHQGTVLSCDISHDATK 1056
Query: 83 LCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNG 142
S A K +W+ D + +L GH+ V FS D LLAT + + IW+ NG
Sbjct: 1057 FSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNG 1116
Query: 143 DILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRI 194
++L HL P + A + WV + FS DG + S +++W +
Sbjct: 1117 ELL----HLCAPLSEEGA-ATHGGWVTDLCFSPDGKMLISAGG--YIKWWNV 1161
Score = 69.3 bits (168), Expect = 3e-12
Identities = 64/246 (26%), Positives = 100/246 (40%), Gaps = 36/246 (14%)
Query: 8 VNEKEIGKLLLNLV-DHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRG 66
+N+K I L +V HT+ V F+ DG I S DKTL+V+ + G + ++
Sbjct: 598 INKKNITNLSRLVVRPHTDAVYHACFSEDGQRI-ASCGADKTLQVFKA-ETGEKLLEIKA 655
Query: 67 HQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDF--SPDGAL 124
H++ V CAFS D + + K V +WN ++ + H V C F S L
Sbjct: 656 HEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLL 715
Query: 125 LATASYDTRVYIWDPHNGDIL-MEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASL 183
LAT S D + +WD + + FGH V FS D +AS
Sbjct: 716 LATGSSDCFLKLWDLNQKECRNTMFGH--------------TNSVNHCRFSPDDKLLASC 761
Query: 184 ADDKMVRFW---RIDEDYPVQVAPLSNGL------------CCAFSTDGSVLAAGTHDGS 228
+ D ++ W +E + V L CC++S DG+ + +
Sbjct: 762 SADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKN-K 820
Query: 229 VYFWAT 234
++ W T
Sbjct: 821 IFLWNT 826
Score = 67.4 bits (163), Expect = 1e-11
Identities = 55/194 (28%), Positives = 85/194 (43%), Gaps = 31/194 (15%)
Query: 14 GKLLLNLVDHTEVVRDLTFAPDGS-LILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVY 72
G+L+ +H+E V F L+L + S D L++WDL + GH N V
Sbjct: 689 GELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK-ECRNTMFGHTNSVN 747
Query: 73 SCAFSPDSSMLCSVGASKAVFLW-----NMDKYTMIRK----LEGHHHD----VVACDFS 119
C FSPD +L S A + LW N K +++ LE D V C +S
Sbjct: 748 HCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWS 807
Query: 120 PDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGL 178
DGA + A+ + ++++W+ + + + GHL WV V FS DG
Sbjct: 808 ADGARIMVAAKN-KIFLWNTDSRSKVADCRGHL--------------SWVHGVMFSPDGS 852
Query: 179 HVASLADDKMVRFW 192
+ +DD+ +R W
Sbjct: 853 SFLTSSDDQTIRLW 866
Score = 61.6 bits (148), Expect = 7e-10
Identities = 45/149 (30%), Positives = 66/149 (44%), Gaps = 29/149 (19%)
Query: 8 VNEKEIGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWD-------------- 53
+N+KE + HT V F+PD L L S S D TL++WD
Sbjct: 730 LNQKECRNTMFG---HTNSVNHCRFSPDDKL-LASCSADGTLKLWDATSANERKSINVKQ 785
Query: 54 ----LKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 109
L+D M+V+ V C++S D + + V A +FLWN D + + GH
Sbjct: 786 FFLNLEDPQEDMEVI------VKCCSWSADGARIM-VAAKNKIFLWNTDSRSKVADCRGH 838
Query: 110 HHDVVACDFSPDGALLATASYDTRVYIWD 138
V FSPDG+ T+S D + +W+
Sbjct: 839 LSWVHGVMFSPDGSSFLTSSDDQTIRLWE 867
Score = 56.6 bits (135), Expect = 2e-08
Identities = 49/183 (26%), Positives = 72/183 (39%), Gaps = 23/183 (12%)
Query: 67 HQNWVYSCAFSPDSSMLCSVGASKAVFLWN--MDKYTMIRKLEGHHHDVVACDFSPDGAL 124
H+ V+ F+ D L S + +WN +DK +R GH V + L
Sbjct: 959 HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLR---GHQETVKDFRLLKNSRL 1015
Query: 125 LATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLA 184
L+ S+D V +W+ G+ +F + V S SHD +S +
Sbjct: 1016 LSW-SFDGTVKVWNIITGNKEKDFV-------------CHQGTVLSCDISHDATKFSSTS 1061
Query: 185 DDKMVRFWRIDEDYPVQVAPLSNGL--CCAFSTDGSVLAAGTHDGSVYFWATPRQVPSLQ 242
DK + W D P+ NG C AFS D ++LA G +G + W L
Sbjct: 1062 ADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN--GELL 1119
Query: 243 HLC 245
HLC
Sbjct: 1120 HLC 1122
Score = 42.7 bits (99), Expect = 3e-04
Identities = 26/91 (28%), Positives = 46/91 (50%), Gaps = 7/91 (7%)
Query: 13 IGKLLLNLVDHTE----VVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQ 68
+ + LNL D E +V+ +++ DG+ I+V+A + +W+ D + + RGH
Sbjct: 783 VKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK--IFLWNT-DSRSKVADCRGHL 839
Query: 69 NWVYSCAFSPDSSMLCSVGASKAVFLWNMDK 99
+WV+ FSPD S + + + LW K
Sbjct: 840 SWVHGVMFSPDGSSFLTSSDDQTIRLWETKK 870
>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
sapiens]
Length = 1248
Score = 77.0 bits (188), Expect = 2e-14
Identities = 54/172 (31%), Positives = 81/172 (47%), Gaps = 10/172 (5%)
Query: 23 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 82
H E V+D + L+ S S D T++VW++ GN K HQ V SC S D++
Sbjct: 1043 HQETVKDFRLLKNSRLL--SWSFDGTVKVWNIIT-GNKEKDFVCHQGTVLSCDISHDATK 1099
Query: 83 LCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNG 142
S A K +W+ D + +L GH+ V FS D LLAT + + IW+ NG
Sbjct: 1100 FSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNG 1159
Query: 143 DILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRI 194
++L HL P + A + WV + FS DG + S +++W +
Sbjct: 1160 ELL----HLCAPLSEEGA-ATHGGWVTDLCFSPDGKMLISAGG--YIKWWNV 1204
Score = 67.0 bits (162), Expect = 2e-11
Identities = 62/230 (26%), Positives = 94/230 (40%), Gaps = 35/230 (15%)
Query: 8 VNEKEIGKLLLNLV-DHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRG 66
+N+K I L +V HT+ V F+ DG I S DKTL+V+ + G + ++
Sbjct: 598 INKKNITNLSRLVVRPHTDAVYHACFSEDGQRI-ASCGADKTLQVFKA-ETGEKLLEIKA 655
Query: 67 HQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDF--SPDGAL 124
H++ V CAFS D + + K V +WN ++ + H V C F S L
Sbjct: 656 HEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLL 715
Query: 125 LATASYDTRVYIWDPHNGDIL-MEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASL 183
LAT S D + +WD + + FGH V FS D +AS
Sbjct: 716 LATGSSDCFLKLWDLNQKECRNTMFGH--------------TNSVNHCRFSPDDKLLASC 761
Query: 184 ADDKMVRFW---RIDEDYPVQVAPLSNGL------------CCAFSTDGS 218
+ D ++ W +E + V L CC++S DG+
Sbjct: 762 SADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGA 811
Score = 67.0 bits (162), Expect = 2e-11
Identities = 56/205 (27%), Positives = 87/205 (42%), Gaps = 45/205 (21%)
Query: 8 VNEKEIGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWD-------------- 53
+N+KE + HT V F+PD L L S S D TL++WD
Sbjct: 730 LNQKECRNTMFG---HTNSVNHCRFSPDDKL-LASCSADGTLKLWDATSANERKSINVKQ 785
Query: 54 ----LKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLE-G 108
L+D M+V+ V C++S D + + V A +FL+++ ++ ++ G
Sbjct: 786 FFLNLEDPQEDMEVI------VKCCSWSADGARIM-VAAKNKIFLFDIHTSGLLGEIHTG 838
Query: 109 HHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRW 167
HH + CDFSP L A V +W+ + + + GHL W
Sbjct: 839 HHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHL--------------SW 884
Query: 168 VRSVSFSHDGLHVASLADDKMVRFW 192
V V FS DG + +DD+ +R W
Sbjct: 885 VHGVMFSPDGSSFLTSSDDQTIRLW 909
Score = 65.5 bits (158), Expect = 5e-11
Identities = 42/174 (24%), Positives = 79/174 (45%), Gaps = 17/174 (9%)
Query: 63 VLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDG 122
V+R H + VY FS D + S GA K + ++ + + +++ H +V+ C FS D
Sbjct: 610 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 669
Query: 123 ALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLH--V 180
+AT S D +V IW+ G+++ + + V F++ H +
Sbjct: 670 RFIATCSVDKKVKIWNSMTGELVHTYDE-------------HSEQVNCCHFTNSSHHLLL 716
Query: 181 ASLADDKMVRFWRID--EDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 232
A+ + D ++ W ++ E ++ C FS D +LA+ + DG++ W
Sbjct: 717 ATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLW 770
Score = 61.2 bits (147), Expect = 9e-10
Identities = 36/130 (27%), Positives = 65/130 (50%), Gaps = 6/130 (4%)
Query: 13 IGKLLLNLVDHTE----VVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQ 68
+ + LNL D E +V+ +++ DG+ I+V+A + ++D+ G + ++ GH
Sbjct: 783 VKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK--IFLFDIHTSGLLGEIHTGHH 840
Query: 69 NWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATA 128
+ + C FSP + + + V LWN D + + GH V FSPDG+ T+
Sbjct: 841 STIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS 900
Query: 129 SYDTRVYIWD 138
S D + +W+
Sbjct: 901 SDDQTIRLWE 910
Score = 60.8 bits (146), Expect = 1e-09
Identities = 69/269 (25%), Positives = 106/269 (39%), Gaps = 36/269 (13%)
Query: 14 GKLLLNLVDHTEVVRDLTFAPDGS-LILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVY 72
G+L+ +H+E V F L+L + S D L++WDL + GH N V
Sbjct: 689 GELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK-ECRNTMFGHTNSVN 747
Query: 73 SCAFSPDSSMLCSVGASKAVFLW-----NMDKYTMIRK----LEGHHHD----VVACDFS 119
C FSPD +L S A + LW N K +++ LE D V C +S
Sbjct: 748 HCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWS 807
Query: 120 PDGALLATASYDTRVYIWDPHNGDILMEF--GHLFPPPTPIFAGGANDRWVRSVSFSHDG 177
DGA + A+ + +++++D H +L E GH ++ FS
Sbjct: 808 ADGARIMVAAKN-KIFLFDIHTSGLLGEIHTGH--------------HSTIQYCDFSPQN 852
Query: 178 LHVASLA-DDKMVRFWRIDEDYPVQVAP--LSNGLCCAFSTDGSVLAAGTHDGSVYFWAT 234
H+A +A V W D V LS FS DGS + D ++ W T
Sbjct: 853 -HLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 911
Query: 235 PRQVPSLQHLCRMSIRRVMPTQEVQELPI 263
+ + + + + V EV L +
Sbjct: 912 KKVCKNSAVMLKQEVDVVFQENEVMVLAV 940
Score = 56.6 bits (135), Expect = 2e-08
Identities = 49/183 (26%), Positives = 72/183 (39%), Gaps = 23/183 (12%)
Query: 67 HQNWVYSCAFSPDSSMLCSVGASKAVFLWN--MDKYTMIRKLEGHHHDVVACDFSPDGAL 124
H+ V+ F+ D L S + +WN +DK +R GH V + L
Sbjct: 1002 HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLR---GHQETVKDFRLLKNSRL 1058
Query: 125 LATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLA 184
L+ S+D V +W+ G+ +F + V S SHD +S +
Sbjct: 1059 LSW-SFDGTVKVWNIITGNKEKDFV-------------CHQGTVLSCDISHDATKFSSTS 1104
Query: 185 DDKMVRFWRIDEDYPVQVAPLSNGL--CCAFSTDGSVLAAGTHDGSVYFWATPRQVPSLQ 242
DK + W D P+ NG C AFS D ++LA G +G + W L
Sbjct: 1105 ADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN--GELL 1162
Query: 243 HLC 245
HLC
Sbjct: 1163 HLC 1165
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 77.0 bits (188), Expect = 2e-14
Identities = 54/172 (31%), Positives = 81/172 (47%), Gaps = 10/172 (5%)
Query: 23 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 82
H E V+D + L+ S S D T++VW++ GN K HQ V SC S D++
Sbjct: 989 HQETVKDFRLLKNSRLL--SWSFDGTVKVWNIIT-GNKEKDFVCHQGTVLSCDISHDATK 1045
Query: 83 LCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNG 142
S A K +W+ D + +L GH+ V FS D LLAT + + IW+ NG
Sbjct: 1046 FSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNG 1105
Query: 143 DILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRI 194
++L HL P + A + WV + FS DG + S +++W +
Sbjct: 1106 ELL----HLCAPLSEEGA-ATHGGWVTDLCFSPDGKMLISAGG--YIKWWNV 1150
Score = 69.3 bits (168), Expect = 3e-12
Identities = 64/246 (26%), Positives = 100/246 (40%), Gaps = 36/246 (14%)
Query: 8 VNEKEIGKLLLNLV-DHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRG 66
+N+K I L +V HT+ V F+ DG I S DKTL+V+ + G + ++
Sbjct: 587 INKKNITNLSRLVVRPHTDAVYHACFSEDGQRI-ASCGADKTLQVFKA-ETGEKLLEIKA 644
Query: 67 HQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDF--SPDGAL 124
H++ V CAFS D + + K V +WN ++ + H V C F S L
Sbjct: 645 HEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLL 704
Query: 125 LATASYDTRVYIWDPHNGDIL-MEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASL 183
LAT S D + +WD + + FGH V FS D +AS
Sbjct: 705 LATGSSDCFLKLWDLNQKECRNTMFGH--------------TNSVNHCRFSPDDKLLASC 750
Query: 184 ADDKMVRFW---RIDEDYPVQVAPLSNGL------------CCAFSTDGSVLAAGTHDGS 228
+ D ++ W +E + V L CC++S DG+ + +
Sbjct: 751 SADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKN-K 809
Query: 229 VYFWAT 234
++ W T
Sbjct: 810 IFLWNT 815
Score = 67.4 bits (163), Expect = 1e-11
Identities = 55/194 (28%), Positives = 85/194 (43%), Gaps = 31/194 (15%)
Query: 14 GKLLLNLVDHTEVVRDLTFAPDGS-LILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVY 72
G+L+ +H+E V F L+L + S D L++WDL + GH N V
Sbjct: 678 GELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK-ECRNTMFGHTNSVN 736
Query: 73 SCAFSPDSSMLCSVGASKAVFLW-----NMDKYTMIRK----LEGHHHD----VVACDFS 119
C FSPD +L S A + LW N K +++ LE D V C +S
Sbjct: 737 HCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWS 796
Query: 120 PDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGL 178
DGA + A+ + ++++W+ + + + GHL WV V FS DG
Sbjct: 797 ADGARIMVAAKN-KIFLWNTDSRSKVADCRGHL--------------SWVHGVMFSPDGS 841
Query: 179 HVASLADDKMVRFW 192
+ +DD+ +R W
Sbjct: 842 SFLTSSDDQTIRLW 855
Score = 61.6 bits (148), Expect = 7e-10
Identities = 45/149 (30%), Positives = 66/149 (44%), Gaps = 29/149 (19%)
Query: 8 VNEKEIGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWD-------------- 53
+N+KE + HT V F+PD L L S S D TL++WD
Sbjct: 719 LNQKECRNTMFG---HTNSVNHCRFSPDDKL-LASCSADGTLKLWDATSANERKSINVKQ 774
Query: 54 ----LKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 109
L+D M+V+ V C++S D + + V A +FLWN D + + GH
Sbjct: 775 FFLNLEDPQEDMEVI------VKCCSWSADGARIM-VAAKNKIFLWNTDSRSKVADCRGH 827
Query: 110 HHDVVACDFSPDGALLATASYDTRVYIWD 138
V FSPDG+ T+S D + +W+
Sbjct: 828 LSWVHGVMFSPDGSSFLTSSDDQTIRLWE 856
Score = 56.6 bits (135), Expect = 2e-08
Identities = 49/183 (26%), Positives = 72/183 (39%), Gaps = 23/183 (12%)
Query: 67 HQNWVYSCAFSPDSSMLCSVGASKAVFLWN--MDKYTMIRKLEGHHHDVVACDFSPDGAL 124
H+ V+ F+ D L S + +WN +DK +R GH V + L
Sbjct: 948 HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLR---GHQETVKDFRLLKNSRL 1004
Query: 125 LATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLA 184
L+ S+D V +W+ G+ +F + V S SHD +S +
Sbjct: 1005 LSW-SFDGTVKVWNIITGNKEKDFV-------------CHQGTVLSCDISHDATKFSSTS 1050
Query: 185 DDKMVRFWRIDEDYPVQVAPLSNGL--CCAFSTDGSVLAAGTHDGSVYFWATPRQVPSLQ 242
DK + W D P+ NG C AFS D ++LA G +G + W L
Sbjct: 1051 ADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN--GELL 1108
Query: 243 HLC 245
HLC
Sbjct: 1109 HLC 1111
Score = 42.7 bits (99), Expect = 3e-04
Identities = 26/91 (28%), Positives = 46/91 (50%), Gaps = 7/91 (7%)
Query: 13 IGKLLLNLVDHTE----VVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQ 68
+ + LNL D E +V+ +++ DG+ I+V+A + +W+ D + + RGH
Sbjct: 772 VKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK--IFLWNT-DSRSKVADCRGHL 828
Query: 69 NWVYSCAFSPDSSMLCSVGASKAVFLWNMDK 99
+WV+ FSPD S + + + LW K
Sbjct: 829 SWVHGVMFSPDGSSFLTSSDDQTIRLWETKK 859
>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
sapiens]
Length = 1237
Score = 77.0 bits (188), Expect = 2e-14
Identities = 54/172 (31%), Positives = 81/172 (47%), Gaps = 10/172 (5%)
Query: 23 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 82
H E V+D + L+ S S D T++VW++ GN K HQ V SC S D++
Sbjct: 1032 HQETVKDFRLLKNSRLL--SWSFDGTVKVWNIIT-GNKEKDFVCHQGTVLSCDISHDATK 1088
Query: 83 LCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNG 142
S A K +W+ D + +L GH+ V FS D LLAT + + IW+ NG
Sbjct: 1089 FSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNG 1148
Query: 143 DILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRI 194
++L HL P + A + WV + FS DG + S +++W +
Sbjct: 1149 ELL----HLCAPLSEEGA-ATHGGWVTDLCFSPDGKMLISAGG--YIKWWNV 1193
Score = 67.0 bits (162), Expect = 2e-11
Identities = 62/230 (26%), Positives = 94/230 (40%), Gaps = 35/230 (15%)
Query: 8 VNEKEIGKLLLNLV-DHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRG 66
+N+K I L +V HT+ V F+ DG I S DKTL+V+ + G + ++
Sbjct: 587 INKKNITNLSRLVVRPHTDAVYHACFSEDGQRI-ASCGADKTLQVFKA-ETGEKLLEIKA 644
Query: 67 HQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDF--SPDGAL 124
H++ V CAFS D + + K V +WN ++ + H V C F S L
Sbjct: 645 HEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLL 704
Query: 125 LATASYDTRVYIWDPHNGDIL-MEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASL 183
LAT S D + +WD + + FGH V FS D +AS
Sbjct: 705 LATGSSDCFLKLWDLNQKECRNTMFGH--------------TNSVNHCRFSPDDKLLASC 750
Query: 184 ADDKMVRFW---RIDEDYPVQVAPLSNGL------------CCAFSTDGS 218
+ D ++ W +E + V L CC++S DG+
Sbjct: 751 SADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGA 800
Score = 67.0 bits (162), Expect = 2e-11
Identities = 56/205 (27%), Positives = 87/205 (42%), Gaps = 45/205 (21%)
Query: 8 VNEKEIGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWD-------------- 53
+N+KE + HT V F+PD L L S S D TL++WD
Sbjct: 719 LNQKECRNTMFG---HTNSVNHCRFSPDDKL-LASCSADGTLKLWDATSANERKSINVKQ 774
Query: 54 ----LKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLE-G 108
L+D M+V+ V C++S D + + V A +FL+++ ++ ++ G
Sbjct: 775 FFLNLEDPQEDMEVI------VKCCSWSADGARIM-VAAKNKIFLFDIHTSGLLGEIHTG 827
Query: 109 HHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRW 167
HH + CDFSP L A V +W+ + + + GHL W
Sbjct: 828 HHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHL--------------SW 873
Query: 168 VRSVSFSHDGLHVASLADDKMVRFW 192
V V FS DG + +DD+ +R W
Sbjct: 874 VHGVMFSPDGSSFLTSSDDQTIRLW 898
Score = 65.5 bits (158), Expect = 5e-11
Identities = 42/174 (24%), Positives = 79/174 (45%), Gaps = 17/174 (9%)
Query: 63 VLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDG 122
V+R H + VY FS D + S GA K + ++ + + +++ H +V+ C FS D
Sbjct: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658
Query: 123 ALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLH--V 180
+AT S D +V IW+ G+++ + + V F++ H +
Sbjct: 659 RFIATCSVDKKVKIWNSMTGELVHTYDE-------------HSEQVNCCHFTNSSHHLLL 705
Query: 181 ASLADDKMVRFWRID--EDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 232
A+ + D ++ W ++ E ++ C FS D +LA+ + DG++ W
Sbjct: 706 ATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLW 759
Score = 61.2 bits (147), Expect = 9e-10
Identities = 36/130 (27%), Positives = 65/130 (50%), Gaps = 6/130 (4%)
Query: 13 IGKLLLNLVDHTE----VVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQ 68
+ + LNL D E +V+ +++ DG+ I+V+A + ++D+ G + ++ GH
Sbjct: 772 VKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK--IFLFDIHTSGLLGEIHTGHH 829
Query: 69 NWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATA 128
+ + C FSP + + + V LWN D + + GH V FSPDG+ T+
Sbjct: 830 STIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS 889
Query: 129 SYDTRVYIWD 138
S D + +W+
Sbjct: 890 SDDQTIRLWE 899
Score = 60.8 bits (146), Expect = 1e-09
Identities = 69/269 (25%), Positives = 106/269 (39%), Gaps = 36/269 (13%)
Query: 14 GKLLLNLVDHTEVVRDLTFAPDGS-LILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVY 72
G+L+ +H+E V F L+L + S D L++WDL + GH N V
Sbjct: 678 GELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK-ECRNTMFGHTNSVN 736
Query: 73 SCAFSPDSSMLCSVGASKAVFLW-----NMDKYTMIRK----LEGHHHD----VVACDFS 119
C FSPD +L S A + LW N K +++ LE D V C +S
Sbjct: 737 HCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWS 796
Query: 120 PDGALLATASYDTRVYIWDPHNGDILMEF--GHLFPPPTPIFAGGANDRWVRSVSFSHDG 177
DGA + A+ + +++++D H +L E GH ++ FS
Sbjct: 797 ADGARIMVAAKN-KIFLFDIHTSGLLGEIHTGH--------------HSTIQYCDFSPQN 841
Query: 178 LHVASLA-DDKMVRFWRIDEDYPVQVAP--LSNGLCCAFSTDGSVLAAGTHDGSVYFWAT 234
H+A +A V W D V LS FS DGS + D ++ W T
Sbjct: 842 -HLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 900
Query: 235 PRQVPSLQHLCRMSIRRVMPTQEVQELPI 263
+ + + + + V EV L +
Sbjct: 901 KKVCKNSAVMLKQEVDVVFQENEVMVLAV 929
Score = 56.6 bits (135), Expect = 2e-08
Identities = 49/183 (26%), Positives = 72/183 (39%), Gaps = 23/183 (12%)
Query: 67 HQNWVYSCAFSPDSSMLCSVGASKAVFLWN--MDKYTMIRKLEGHHHDVVACDFSPDGAL 124
H+ V+ F+ D L S + +WN +DK +R GH V + L
Sbjct: 991 HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLR---GHQETVKDFRLLKNSRL 1047
Query: 125 LATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLA 184
L+ S+D V +W+ G+ +F + V S SHD +S +
Sbjct: 1048 LSW-SFDGTVKVWNIITGNKEKDFV-------------CHQGTVLSCDISHDATKFSSTS 1093
Query: 185 DDKMVRFWRIDEDYPVQVAPLSNGL--CCAFSTDGSVLAAGTHDGSVYFWATPRQVPSLQ 242
DK + W D P+ NG C AFS D ++LA G +G + W L
Sbjct: 1094 ADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN--GELL 1151
Query: 243 HLC 245
HLC
Sbjct: 1152 HLC 1154
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 77.0 bits (188), Expect = 2e-14
Identities = 58/212 (27%), Positives = 82/212 (38%), Gaps = 17/212 (8%)
Query: 23 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 82
HT VR + F DG V+AS DKT++VW + L H NWV FSPD +
Sbjct: 64 HTATVRSVHFCSDGQSF-VTASDDKTVKVWATHRQKFLFS-LSQHINWVRCAKFSPDGRL 121
Query: 83 LCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNG 142
+ S K V LW+ + H V DF P G +A A D V +WD
Sbjct: 122 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH 181
Query: 143 DILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQV 202
+L + + V +SF G ++ + + D ++ + E +
Sbjct: 182 RLLQHY-------------QLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYT 228
Query: 203 APLSNG--LCCAFSTDGSVLAAGTHDGSVYFW 232
G AFS G A+G D V W
Sbjct: 229 LHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 260
Score = 77.0 bits (188), Expect = 2e-14
Identities = 57/184 (30%), Positives = 83/184 (45%), Gaps = 17/184 (9%)
Query: 15 KLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSC 74
K L +L H VR F+PDG LI VSAS DKT+++WD K + H +V
Sbjct: 98 KFLFSLSQHINWVRCAKFSPDGRLI-VSASDDKTVKLWD-KSSRECVHSYCEHGGFVTYV 155
Query: 75 AFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRV 134
F P + + + G V +W++ + +++ + H V F P G L TAS D+ +
Sbjct: 156 DFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTL 215
Query: 135 YIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWR 193
I D G +L GH P T V+FS G + AS D+ V W+
Sbjct: 216 KILDLMEGRLLYTLHGHQGPATT--------------VAFSRTGEYFASGGSDEQVMVWK 261
Query: 194 IDED 197
+ D
Sbjct: 262 SNFD 265
Score = 73.2 bits (178), Expect = 2e-13
Identities = 61/212 (28%), Positives = 91/212 (42%), Gaps = 23/212 (10%)
Query: 23 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 82
H + V + F+P G L L S SRDKT+R+W G V R H V S F D
Sbjct: 22 HKDAVTCVNFSPSGHL-LASGSRDKTVRIWVPNVKGEST-VFRAHTATVRSVHFCSDGQS 79
Query: 83 LCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNG 142
+ K V +W + + L H + V FSPDG L+ +AS D V +WD +
Sbjct: 80 FVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR 139
Query: 143 DILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW-----RIDED 197
+ + + GG +V V F G +A+ D V+ W R+ +
Sbjct: 140 ECVHSYCE---------HGG----FVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQH 186
Query: 198 YPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSV 229
Y + A + NGL +F G+ L + D ++
Sbjct: 187 YQLHSAAV-NGL--SFHPSGNYLITASSDSTL 215
Score = 65.1 bits (157), Expect = 6e-11
Identities = 52/189 (27%), Positives = 69/189 (36%), Gaps = 16/189 (8%)
Query: 46 DKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRK 105
D L VW +K + GH++ V FSP +L S K V +W +
Sbjct: 2 DSCLMVWHMKPQSRAYR-FTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV 60
Query: 106 LEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGAND 165
H V + F DG TAS D V +W H L F+ +
Sbjct: 61 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFL-------------FSLSQHI 107
Query: 166 RWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLC--CAFSTDGSVLAAG 223
WVR FS DG + S +DDK V+ W V G F G+ +AA
Sbjct: 108 NWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAA 167
Query: 224 THDGSVYFW 232
D +V W
Sbjct: 168 GMDNTVKVW 176
Score = 33.9 bits (76), Expect = 0.16
Identities = 24/72 (33%), Positives = 33/72 (45%), Gaps = 2/72 (2%)
Query: 168 VRSVSFSHDGLHVASLADDKMVRFW--RIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTH 225
V V+FS G +AS + DK VR W + + V A + F +DG +
Sbjct: 26 VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASD 85
Query: 226 DGSVYFWATPRQ 237
D +V WAT RQ
Sbjct: 86 DKTVKVWATHRQ 97
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 77.0 bits (188), Expect = 2e-14
Identities = 58/212 (27%), Positives = 82/212 (38%), Gaps = 17/212 (8%)
Query: 23 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 82
HT VR + F DG V+AS DKT++VW + L H NWV FSPD +
Sbjct: 102 HTATVRSVHFCSDGQSF-VTASDDKTVKVWATHRQKFLFS-LSQHINWVRCAKFSPDGRL 159
Query: 83 LCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNG 142
+ S K V LW+ + H V DF P G +A A D V +WD
Sbjct: 160 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH 219
Query: 143 DILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQV 202
+L + + V +SF G ++ + + D ++ + E +
Sbjct: 220 RLLQHY-------------QLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYT 266
Query: 203 APLSNG--LCCAFSTDGSVLAAGTHDGSVYFW 232
G AFS G A+G D V W
Sbjct: 267 LHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 77.0 bits (188), Expect = 2e-14
Identities = 57/184 (30%), Positives = 83/184 (45%), Gaps = 17/184 (9%)
Query: 15 KLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSC 74
K L +L H VR F+PDG LI VSAS DKT+++WD K + H +V
Sbjct: 136 KFLFSLSQHINWVRCAKFSPDGRLI-VSASDDKTVKLWD-KSSRECVHSYCEHGGFVTYV 193
Query: 75 AFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRV 134
F P + + + G V +W++ + +++ + H V F P G L TAS D+ +
Sbjct: 194 DFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTL 253
Query: 135 YIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWR 193
I D G +L GH P T V+FS G + AS D+ V W+
Sbjct: 254 KILDLMEGRLLYTLHGHQGPATT--------------VAFSRTGEYFASGGSDEQVMVWK 299
Query: 194 IDED 197
+ D
Sbjct: 300 SNFD 303
Score = 73.2 bits (178), Expect = 2e-13
Identities = 50/179 (27%), Positives = 83/179 (46%), Gaps = 15/179 (8%)
Query: 56 DDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVA 115
+D ++ + +GH++ V FS ++ L S + +W+M + + GH V
Sbjct: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
Query: 116 CDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSH 175
+FSP G LLA+ S D V IW P+ + +F A+ VRSV F
Sbjct: 67 VNFSPSGHLLASGSRDKTVRIWVPN-----------VKGESTVFR--AHTATVRSVHFCS 113
Query: 176 DGLHVASLADDKMVRFWRID-EDYPVQVAPLSNGLCCA-FSTDGSVLAAGTHDGSVYFW 232
DG + +DDK V+ W + + ++ N + CA FS DG ++ + + D +V W
Sbjct: 114 DGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172
Score = 73.2 bits (178), Expect = 2e-13
Identities = 61/212 (28%), Positives = 91/212 (42%), Gaps = 23/212 (10%)
Query: 23 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 82
H + V + F+P G L L S SRDKT+R+W G V R H V S F D
Sbjct: 60 HKDAVTCVNFSPSGHL-LASGSRDKTVRIWVPNVKGEST-VFRAHTATVRSVHFCSDGQS 117
Query: 83 LCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNG 142
+ K V +W + + L H + V FSPDG L+ +AS D V +WD +
Sbjct: 118 FVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR 177
Query: 143 DILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW-----RIDED 197
+ + + GG +V V F G +A+ D V+ W R+ +
Sbjct: 178 ECVHSYCE---------HGG----FVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQH 224
Query: 198 YPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSV 229
Y + A + NGL +F G+ L + D ++
Sbjct: 225 YQLHSAAV-NGL--SFHPSGNYLITASSDSTL 253
Score = 47.0 bits (110), Expect = 2e-05
Identities = 40/136 (29%), Positives = 56/136 (41%), Gaps = 15/136 (11%)
Query: 104 RKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGA 163
R +GH V DFS + LA+ S D+ + +W H+ P G
Sbjct: 13 RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVW------------HMKPQSRAYRFTGH 60
Query: 164 NDRWVRSVSFSHDGLHVASLADDKMVRFW--RIDEDYPVQVAPLSNGLCCAFSTDGSVLA 221
D V V+FS G +AS + DK VR W + + V A + F +DG
Sbjct: 61 KDA-VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFV 119
Query: 222 AGTHDGSVYFWATPRQ 237
+ D +V WAT RQ
Sbjct: 120 TASDDKTVKVWATHRQ 135
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 77.0 bits (188), Expect = 2e-14
Identities = 58/212 (27%), Positives = 82/212 (38%), Gaps = 17/212 (8%)
Query: 23 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 82
HT VR + F DG V+AS DKT++VW + L H NWV FSPD +
Sbjct: 102 HTATVRSVHFCSDGQSF-VTASDDKTVKVWATHRQKFLFS-LSQHINWVRCAKFSPDGRL 159
Query: 83 LCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNG 142
+ S K V LW+ + H V DF P G +A A D V +WD
Sbjct: 160 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH 219
Query: 143 DILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQV 202
+L + + V +SF G ++ + + D ++ + E +
Sbjct: 220 RLLQHY-------------QLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYT 266
Query: 203 APLSNG--LCCAFSTDGSVLAAGTHDGSVYFW 232
G AFS G A+G D V W
Sbjct: 267 LHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 77.0 bits (188), Expect = 2e-14
Identities = 57/184 (30%), Positives = 83/184 (45%), Gaps = 17/184 (9%)
Query: 15 KLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSC 74
K L +L H VR F+PDG LI VSAS DKT+++WD K + H +V
Sbjct: 136 KFLFSLSQHINWVRCAKFSPDGRLI-VSASDDKTVKLWD-KSSRECVHSYCEHGGFVTYV 193
Query: 75 AFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRV 134
F P + + + G V +W++ + +++ + H V F P G L TAS D+ +
Sbjct: 194 DFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTL 253
Query: 135 YIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWR 193
I D G +L GH P T V+FS G + AS D+ V W+
Sbjct: 254 KILDLMEGRLLYTLHGHQGPATT--------------VAFSRTGEYFASGGSDEQVMVWK 299
Query: 194 IDED 197
+ D
Sbjct: 300 SNFD 303
Score = 73.2 bits (178), Expect = 2e-13
Identities = 50/179 (27%), Positives = 83/179 (46%), Gaps = 15/179 (8%)
Query: 56 DDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVA 115
+D ++ + +GH++ V FS ++ L S + +W+M + + GH V
Sbjct: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
Query: 116 CDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSH 175
+FSP G LLA+ S D V IW P+ + +F A+ VRSV F
Sbjct: 67 VNFSPSGHLLASGSRDKTVRIWVPN-----------VKGESTVFR--AHTATVRSVHFCS 113
Query: 176 DGLHVASLADDKMVRFWRID-EDYPVQVAPLSNGLCCA-FSTDGSVLAAGTHDGSVYFW 232
DG + +DDK V+ W + + ++ N + CA FS DG ++ + + D +V W
Sbjct: 114 DGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172
Score = 73.2 bits (178), Expect = 2e-13
Identities = 61/212 (28%), Positives = 91/212 (42%), Gaps = 23/212 (10%)
Query: 23 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 82
H + V + F+P G L L S SRDKT+R+W G V R H V S F D
Sbjct: 60 HKDAVTCVNFSPSGHL-LASGSRDKTVRIWVPNVKGEST-VFRAHTATVRSVHFCSDGQS 117
Query: 83 LCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNG 142
+ K V +W + + L H + V FSPDG L+ +AS D V +WD +
Sbjct: 118 FVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR 177
Query: 143 DILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW-----RIDED 197
+ + + GG +V V F G +A+ D V+ W R+ +
Sbjct: 178 ECVHSYCE---------HGG----FVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQH 224
Query: 198 YPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSV 229
Y + A + NGL +F G+ L + D ++
Sbjct: 225 YQLHSAAV-NGL--SFHPSGNYLITASSDSTL 253
Score = 47.0 bits (110), Expect = 2e-05
Identities = 40/136 (29%), Positives = 56/136 (41%), Gaps = 15/136 (11%)
Query: 104 RKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGA 163
R +GH V DFS + LA+ S D+ + +W H+ P G
Sbjct: 13 RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVW------------HMKPQSRAYRFTGH 60
Query: 164 NDRWVRSVSFSHDGLHVASLADDKMVRFW--RIDEDYPVQVAPLSNGLCCAFSTDGSVLA 221
D V V+FS G +AS + DK VR W + + V A + F +DG
Sbjct: 61 KDA-VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFV 119
Query: 222 AGTHDGSVYFWATPRQ 237
+ D +V WAT RQ
Sbjct: 120 TASDDKTVKVWATHRQ 135
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 77.0 bits (188), Expect = 2e-14
Identities = 45/135 (33%), Positives = 67/135 (49%), Gaps = 11/135 (8%)
Query: 23 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSS- 81
HT V + + P G+L L S S D TL++W +K D N + L+ H +Y+ +SP
Sbjct: 348 HTNEVNAIKWDPTGNL-LASCSDDMTLKIWSMKQD-NCVHDLQAHNKEIYTIKWSPTGPG 405
Query: 82 --------MLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTR 133
ML S V LW++D+ I L H V + FSPDG LA+ S+D
Sbjct: 406 TNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKC 465
Query: 134 VYIWDPHNGDILMEF 148
V+IW+ G ++ +
Sbjct: 466 VHIWNTQTGALVHSY 480
Score = 66.2 bits (160), Expect = 3e-11
Identities = 52/198 (26%), Positives = 84/198 (42%), Gaps = 24/198 (12%)
Query: 42 SASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYT 101
S S D + V L D +K +GH N V + + P ++L S + +W+M +
Sbjct: 324 SCSTDMCIHVCKLGQD-RPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDN 382
Query: 102 MIRKLEGHHHDVVACDFSPDG---------ALLATASYDTRVYIWDPHNGDILMEFGHLF 152
+ L+ H+ ++ +SP G +LA+AS+D+ V +WD G +
Sbjct: 383 CVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQ 442
Query: 153 PPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLC-C 211
P V SV+FS DG ++AS + DK V W V + G+
Sbjct: 443 EP-------------VYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTGGIFEV 489
Query: 212 AFSTDGSVLAAGTHDGSV 229
++ G + A DGSV
Sbjct: 490 CWNAAGDKVGASASDGSV 507
Score = 58.9 bits (141), Expect = 5e-09
Identities = 31/75 (41%), Positives = 41/75 (54%), Gaps = 1/75 (1%)
Query: 34 PDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVF 93
P+ +L+L SAS D T+R+WD+ D G + L HQ VYS AFSPD L S K V
Sbjct: 409 PNANLMLASASFDSTVRLWDV-DRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVH 467
Query: 94 LWNMDKYTMIRKLEG 108
+WN ++ G
Sbjct: 468 IWNTQTGALVHSYRG 482
Score = 58.2 bits (139), Expect = 8e-09
Identities = 62/250 (24%), Positives = 101/250 (40%), Gaps = 41/250 (16%)
Query: 14 GKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQ----- 68
G L L H + L + G+ IL SA DKT +WD G + H
Sbjct: 256 GNLASTLGQHKGPIFALKWNKKGNFIL-SAGVDKTTIIWDAHT-GEAKQQFPFHSAPALD 313
Query: 69 -NWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLAT 127
+W + F+ S+ +C + + + + I+ +GH ++V A + P G LLA+
Sbjct: 314 VDWQSNNTFASCSTDMC-------IHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLAS 366
Query: 128 ASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDG---------L 178
S D + IW + + + A+++ + ++ +S G L
Sbjct: 367 CSDDMTLKIWSMKQDNCVHDLQ-------------AHNKEIYTIKWSPTGPGTNNPNANL 413
Query: 179 HVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSVYFWATPR 236
+AS + D VR W +D + AFS DG LA+G+ D V+ W T
Sbjct: 414 MLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNT-- 471
Query: 237 QVPSLQHLCR 246
Q +L H R
Sbjct: 472 QTGALVHSYR 481
Score = 53.9 bits (128), Expect = 1e-07
Identities = 51/189 (26%), Positives = 80/189 (42%), Gaps = 39/189 (20%)
Query: 53 DLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYT-------MIRK 105
D++ N VLRGH++ V+ CA++P S +L S +WN+ + + ++R
Sbjct: 154 DVEIPPNKAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRH 213
Query: 106 L--EG-----HHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPI 158
EG + DV + D++ +G LLAT SYD IW +G++ G PI
Sbjct: 214 CIREGGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIW-TKDGNLASTLGQ---HKGPI 269
Query: 159 FAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW-----RIDEDYPVQVAPL------SN 207
FA + ++ G + S DK W + +P AP SN
Sbjct: 270 FA----------LKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSN 319
Query: 208 GLCCAFSTD 216
+ STD
Sbjct: 320 NTFASCSTD 328
Score = 30.0 bits (66), Expect = 2.3
Identities = 19/60 (31%), Positives = 31/60 (51%), Gaps = 2/60 (3%)
Query: 7 RVNEKEIGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRG 66
R+ + + G + L H E V + F+PDG L S S DK + +W+ + G ++ RG
Sbjct: 425 RLWDVDRGICIHTLTKHQEPVYSVAFSPDGR-YLASGSFDKCVHIWNTQ-TGALVHSYRG 482
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 76.6 bits (187), Expect = 2e-14
Identities = 60/252 (23%), Positives = 101/252 (40%), Gaps = 33/252 (13%)
Query: 12 EIGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWV 71
E GK HT + L+F P +L+ + S D T ++WD+++ G + LRGH +
Sbjct: 165 ETGKCYHTFRGHTAEIVCLSFNPQSTLV-ATGSMDTTAKLWDIQN-GEEVYTLRGHSAEI 222
Query: 72 YSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYD 131
S +F+ + + V +W+ D + L GH ++ + F+ D +L+ T S D
Sbjct: 223 ISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMD 282
Query: 132 TRVYIWDPHNGDILMEF-GH-------LFPPPTPIFAGGANDRWVR-------------- 169
+WD NG + GH F + A + D R
Sbjct: 283 KTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLE 342
Query: 170 -------SVSFSHDGLHVASLADDKMVRFWRIDEDYPVQV--APLSNGLCCAFSTDGSVL 220
+SF+ G H+ + + DK R W +QV CAF+ G+++
Sbjct: 343 GHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIV 402
Query: 221 AAGTHDGSVYFW 232
G+ D + W
Sbjct: 403 ITGSKDNTCRIW 414
Score = 69.3 bits (168), Expect = 3e-12
Identities = 48/184 (26%), Positives = 80/184 (43%), Gaps = 15/184 (8%)
Query: 10 EKEIGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQN 69
+ + G+ + L+ H + +F D SLIL + S DKT ++WD + G + L GH +
Sbjct: 247 DADTGRKVNILIGHCAEISSASFNWDCSLIL-TGSMDKTCKLWDATN-GKCVATLTGHDD 304
Query: 70 WVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATAS 129
+ F ++ + A +++ I KLEGH ++ F+P G L T S
Sbjct: 305 EILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGS 364
Query: 130 YDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMV 189
D IWD G L + G ++ + S +F++ G V + + D
Sbjct: 365 SDKTARIWDAQTGQCLQ-----------VLEGHTDE--IFSCAFNYKGNIVITGSKDNTC 411
Query: 190 RFWR 193
R WR
Sbjct: 412 RIWR 415
Score = 65.9 bits (159), Expect = 4e-11
Identities = 55/236 (23%), Positives = 99/236 (41%), Gaps = 24/236 (10%)
Query: 14 GKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYS 73
G+ L L H VV + F + + S DKT ++W + + G RGH +
Sbjct: 124 GEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSV-ETGKCYHTFRGHTAEIVC 182
Query: 74 CAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTR 133
+F+P S+++ + LW++ + L GH ++++ F+ G + T S+D
Sbjct: 183 LSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHT 242
Query: 134 VYIWDPHNG-DILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW 192
V +WD G + + GH + S SF+ D + + + DK + W
Sbjct: 243 VVVWDADTGRKVNILIGHCAE--------------ISSASFNWDCSLILTGSMDKTCKLW 288
Query: 193 RIDEDYPVQVAPLSNG----LCCAFSTDGSVLAAGTHDGS--VYFWATPRQVPSLQ 242
D VA L+ L F G ++A + DG+ ++ AT + + L+
Sbjct: 289 --DATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLE 342
Score = 44.7 bits (104), Expect = 9e-05
Identities = 42/178 (23%), Positives = 72/178 (40%), Gaps = 20/178 (11%)
Query: 60 MMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDF- 118
+ KVL+ H + + A + S + + LW+ + LEGH + V A F
Sbjct: 84 LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN 143
Query: 119 SPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDG 177
+P G +AT S+D +W G F GH + +SF+
Sbjct: 144 NPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAE--------------IVCLSFNPQS 189
Query: 178 LHVASLADDKMVRFWRI---DEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 232
VA+ + D + W I +E Y ++ + + +F+T G + G+ D +V W
Sbjct: 190 TLVATGSMDTTAKLWDIQNGEEVYTLR-GHSAEIISLSFNTSGDRIITGSFDHTVVVW 246
Score = 33.1 bits (74), Expect = 0.27
Identities = 26/135 (19%), Positives = 56/135 (41%), Gaps = 14/135 (10%)
Query: 100 YTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIF 159
+ + + L+ H + + G+ T SYD +WD +G+ E L ++
Sbjct: 82 FYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGE---ELNTLEGHRNVVY 138
Query: 160 AGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRID--EDYPVQVAPLSNGLCCAFSTDG 217
A N+ + G +A+ + DK + W ++ + Y + +C +F+
Sbjct: 139 AIAFNNPY---------GDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQS 189
Query: 218 SVLAAGTHDGSVYFW 232
+++A G+ D + W
Sbjct: 190 TLVATGSMDTTAKLW 204
>gi|13376840 WD repeat domain 61 [Homo sapiens]
Length = 305
Score = 75.9 bits (185), Expect = 4e-14
Identities = 40/125 (32%), Positives = 68/125 (54%), Gaps = 2/125 (1%)
Query: 14 GKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYS 73
GKLL L H +R LTF+PD L LV+AS D ++++D++ N+ L GH +WV +
Sbjct: 180 GKLLHTLEGHAMPIRSLTFSPDSQL-LVTASDDGYIKIYDVQH-ANLAGTLSGHASWVLN 237
Query: 74 CAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTR 133
AF PD + S + K+V +W++ T + H V ++ +G+ + + D
Sbjct: 238 VAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQE 297
Query: 134 VYIWD 138
++I+D
Sbjct: 298 IHIYD 302
Score = 60.5 bits (145), Expect = 2e-09
Identities = 44/165 (26%), Positives = 76/165 (46%), Gaps = 15/165 (9%)
Query: 30 LTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGAS 89
L F+PD S L + + + ++ + + G L ++ S A+SPD L S
Sbjct: 112 LAFSPD-SQYLATGTHVGKVNIFGV-ESGKKEYSLDTRGKFILSIAYSPDGKYLASGAID 169
Query: 90 KAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFG 149
+ ++++ ++ LEGH + + FSPD LL TAS D + I+D + ++
Sbjct: 170 GIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANL----- 224
Query: 150 HLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRI 194
+G A+ WV +V+F D H S + DK V+ W +
Sbjct: 225 ------AGTLSGHAS--WVLNVAFCPDDTHFVSSSSDKSVKVWDV 261
Score = 58.9 bits (141), Expect = 5e-09
Identities = 53/203 (26%), Positives = 89/203 (43%), Gaps = 30/203 (14%)
Query: 39 ILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMD 98
I S+S D +R+WDL ++G +K + ++ AFSPDS L + V ++ ++
Sbjct: 78 IAASSSLDAHIRLWDL-ENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVE 136
Query: 99 KYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTP 157
L+ +++ +SPDG LA+ + D + I+D G +L GH P
Sbjct: 137 SGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMP---- 192
Query: 158 IFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLC------- 210
+RS++FS D + + +DD ++ Y VQ A L+ L
Sbjct: 193 ----------IRSLTFSPDSQLLVTASDDGYIKI------YDVQHANLAGTLSGHASWVL 236
Query: 211 -CAFSTDGSVLAAGTHDGSVYFW 232
AF D + + + D SV W
Sbjct: 237 NVAFCPDDTHFVSSSSDKSVKVW 259
Score = 45.8 bits (107), Expect = 4e-05
Identities = 42/181 (23%), Positives = 79/181 (43%), Gaps = 23/181 (12%)
Query: 58 GNMMKVLRGHQNWVYSCAF------SPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHH 111
G + K + H + ++S A+ + ++ + S+ V+ W ++ + LEGH
Sbjct: 6 GILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQL 65
Query: 112 DVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSV 171
VV+ D S + A++S D + +WD NG + G D W ++
Sbjct: 66 GVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSID-----------AGPVDAW--TL 112
Query: 172 SFSHDGLHVASLADDKMVRFWRID---EDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGS 228
+FS D ++A+ V + ++ ++Y + L A+S DG LA+G DG
Sbjct: 113 AFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRG-KFILSIAYSPDGKYLASGAIDGI 171
Query: 229 V 229
+
Sbjct: 172 I 172
>gi|5902134 coronin, actin binding protein, 1A [Homo sapiens]
Length = 461
Score = 74.7 bits (182), Expect = 8e-14
Identities = 59/237 (24%), Positives = 102/237 (43%), Gaps = 16/237 (6%)
Query: 23 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKV------LRGHQNWVYSCAF 76
HT V D+ + P ++ S S D T+ VW++ D G M+ + L GH V A+
Sbjct: 80 HTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLMLPLREPVVTLEGHTKRVGIVAW 139
Query: 77 SPDS-SMLCSVGASKAVFLWNMDKYTMIRKL--EGHHHDVVACDFSPDGALLATASYDTR 133
+ ++L S G + +W++ + L E H + + D+S DG L+ T+ D R
Sbjct: 140 HTTAQNVLLSAGCDNVIMVWDVGTGAAMLTLGPEVHPDTIYSVDWSRDGGLICTSCRDKR 199
Query: 134 VYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWR 193
V I +P G ++ E P+ A ++ + + FS +L D K
Sbjct: 200 VRIIEPRKGTVVAEKDRPHEGTRPVRAVFVSEGKILTTGFSRMSERQVALWDTK-----H 254
Query: 194 IDEDYPVQVAPLSNGLCCAFSTDGS--VLAAGTHDGSVYFWATPRQVPSLQHLCRMS 248
++E +Q S+G+ F + V G D S+ ++ + P L +L S
Sbjct: 255 LEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEAPFLHYLSMFS 311
Score = 41.2 bits (95), Expect = 0.001
Identities = 31/128 (24%), Positives = 58/128 (45%), Gaps = 6/128 (4%)
Query: 17 LLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKV-LRGHQNWVYSCA 75
++ L HT+ V + + +L+SA D + VWD+ M+ + H + +YS
Sbjct: 124 VVTLEGHTKRVGIVAWHTTAQNVLLSAGCDNVIMVWDVGTGAAMLTLGPEVHPDTIYSVD 183
Query: 76 FSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDV--VACDFSPDGALLATA---SY 130
+S D ++C+ K V + K T++ + + H V F +G +L T
Sbjct: 184 WSRDGGLICTSCRDKRVRIIEPRKGTVVAEKDRPHEGTRPVRAVFVSEGKILTTGFSRMS 243
Query: 131 DTRVYIWD 138
+ +V +WD
Sbjct: 244 ERQVALWD 251
>gi|4757988 WD repeat domain 39 [Homo sapiens]
Length = 339
Score = 74.3 bits (181), Expect = 1e-13
Identities = 56/205 (27%), Positives = 86/205 (41%), Gaps = 45/205 (21%)
Query: 30 LTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVL--RGHQNWVYSCAFSPDSSMLCSVG 87
L + P G+L L S D+ +R+W + D + K + GHQ V A+SP + L S
Sbjct: 22 LAWNPAGTL-LASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASAS 80
Query: 88 ASKAVFLW--NMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWD------- 138
+W N D + + LEGH ++V + ++P G LLAT S D V++W+
Sbjct: 81 FDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEY 140
Query: 139 -------PHNGDILMEFGHLFPPPTPIFAGGANDRWVR---------------------- 169
H D+ H P + A + D V+
Sbjct: 141 ECVSVLNSHTQDVKHVVWH---PSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTV 197
Query: 170 -SVSFSHDGLHVASLADDKMVRFWR 193
S++F G +AS +DD+ VR WR
Sbjct: 198 WSLAFDPSGQRLASCSDDRTVRIWR 222
Score = 50.8 bits (120), Expect = 1e-06
Identities = 57/214 (26%), Positives = 93/214 (43%), Gaps = 43/214 (20%)
Query: 8 VNEKEIGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVW-DLKDDGNMMKVLRG 66
V+E++ + + L HT+ V+ + + P L L SAS D T++++ + +DD L G
Sbjct: 134 VDEEDEYECVSVLNSHTQDVKHVVWHPSQEL-LASASYDDTVKLYREEEDDWVCCATLEG 192
Query: 67 HQNWVYSCAFSPDSSMLCSVGASKAVFLWNM---------------DKYTMIRKLEGHH- 110
H++ V+S AF P L S + V +W + I L G H
Sbjct: 193 HESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHS 252
Query: 111 ---HDVVACDFSPDGALLATASYDT-RVYIWDPHNGDILMEFGHLFPPPTPIFA-----G 161
+D+ C + GAL D RV+ DP++ P P F+
Sbjct: 253 RTIYDIAWCQLT--GALATACGDDAIRVFQEDPNS-----------DPQQPTFSLTAHLH 299
Query: 162 GANDRWVRSVSFS--HDGLHVASLADDKMVRFWR 193
A+ + V V+++ GL +AS +DD V FW+
Sbjct: 300 QAHSQDVNCVAWNPKEPGL-LASCSDDGEVAFWK 332
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.137 0.441
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,591,710
Number of Sequences: 37866
Number of extensions: 499166
Number of successful extensions: 3450
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 221
Number of HSP's successfully gapped in prelim test: 114
Number of HSP's that attempted gapping in prelim test: 1148
Number of HSP's gapped (non-prelim): 1344
length of query: 275
length of database: 18,247,518
effective HSP length: 101
effective length of query: 174
effective length of database: 14,423,052
effective search space: 2509611048
effective search space used: 2509611048
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.