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Search of human proteins with 197313787
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|197313787 desmoglein 4 isoform 1 [Homo sapiens]
(1059 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|197313787 desmoglein 4 isoform 1 [Homo sapiens] 2146 0.0
gi|29789445 desmoglein 4 isoform 2 [Homo sapiens] 2053 0.0
gi|119964718 desmoglein 3 preproprotein [Homo sapiens] 922 0.0
gi|116534898 desmoglein 2 preproprotein [Homo sapiens] 615 e-176
gi|119703744 desmoglein 1 preproprotein [Homo sapiens] 605 e-173
gi|13435364 desmocollin 2 isoform Dsc2a preproprotein [Homo sapi... 361 2e-99
gi|148539846 desmocollin 3 isoform Dsc3a preproprotein [Homo sap... 343 6e-94
gi|13435361 desmocollin 1 isoform Dsc1a preproprotein [Homo sapi... 333 7e-91
gi|13435366 desmocollin 2 isoform Dsc2b preproprotein [Homo sapi... 320 4e-87
gi|14589893 cadherin 4, type 1 preproprotein [Homo sapiens] 313 4e-85
gi|148539848 desmocollin 3 isoform Dsc3b preproprotein [Homo sap... 310 5e-84
gi|14589889 cadherin 2, type 1 preproprotein [Homo sapiens] 309 1e-83
gi|4826702 desmocollin 1 isoform Dsc1b preproprotein [Homo sapiens] 303 7e-82
gi|4826669 cadherin 15 preproprotein [Homo sapiens] 291 2e-78
gi|4757960 cadherin 1, type 1 preproprotein [Homo sapiens] 289 1e-77
gi|4502719 cadherin 13 preproprotein [Homo sapiens] 278 1e-74
gi|29570800 cadherin-like 26 isoform a [Homo sapiens] 274 4e-73
gi|14589891 cadherin 3, type 1 preproprotein [Homo sapiens] 266 1e-70
gi|4826673 cadherin 6, type 2 preproprotein [Homo sapiens] 194 3e-49
gi|16306487 cadherin 7, type 2 preproprotein [Homo sapiens] 194 3e-49
gi|16306489 cadherin 7, type 2 preproprotein [Homo sapiens] 194 3e-49
gi|16445393 cadherin 12, type 2 preproprotein [Homo sapiens] 194 4e-49
gi|4826671 cadherin 18, type 2 preproprotein [Homo sapiens] 189 2e-47
gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens] 184 5e-46
gi|16306532 cadherin 11, type 2 preproprotein [Homo sapiens] 176 1e-43
gi|221316595 cadherin 17 precursor [Homo sapiens] 176 1e-43
gi|221316593 cadherin 17 precursor [Homo sapiens] 176 1e-43
gi|90193626 cadherin 9, type 2 preproprotein [Homo sapiens] 174 4e-43
gi|16306530 cadherin 10, type 2 preproprotein [Homo sapiens] 174 5e-43
gi|16753221 cadherin 22 precursor [Homo sapiens] 172 2e-42
>gi|197313787 desmoglein 4 isoform 1 [Homo sapiens]
Length = 1059
Score = 2146 bits (5561), Expect = 0.0
Identities = 1059/1059 (100%), Positives = 1059/1059 (100%)
Query: 1 MDWLFFRNICLLIILMVVMEVNSEFIVEVKEFDIENGTTKWQTVRRQKREWIKFAAACRE 60
MDWLFFRNICLLIILMVVMEVNSEFIVEVKEFDIENGTTKWQTVRRQKREWIKFAAACRE
Sbjct: 1 MDWLFFRNICLLIILMVVMEVNSEFIVEVKEFDIENGTTKWQTVRRQKREWIKFAAACRE 60
Query: 61 GEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTINPRTGEINITSVVDREIT 120
GEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTINPRTGEINITSVVDREIT
Sbjct: 61 GEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTINPRTGEINITSVVDREIT 120
Query: 121 PLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQSVYTASIEENSDANTLVVKLC 180
PLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQSVYTASIEENSDANTLVVKLC
Sbjct: 121 PLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQSVYTASIEENSDANTLVVKLC 180
Query: 181 ATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEVCTMSSFLDREQHSMYNLVVRGS 240
ATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEVCTMSSFLDREQHSMYNLVVRGS
Sbjct: 181 ATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEVCTMSSFLDREQHSMYNLVVRGS 240
Query: 241 DRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENCLSSELIRLQAIDLDEEGT 300
DRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENCLSSELIRLQAIDLDEEGT
Sbjct: 241 DRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENCLSSELIRLQAIDLDEEGT 300
Query: 301 DNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQAPNIQLSIGVKNQADFHYS 360
DNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQAPNIQLSIGVKNQADFHYS
Sbjct: 301 DNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQAPNIQLSIGVKNQADFHYS 360
Query: 361 VASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKGSSLLNYVLGTYTAIDLDTGN 420
VASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKGSSLLNYVLGTYTAIDLDTGN
Sbjct: 361 VASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKGSSLLNYVLGTYTAIDLDTGN 420
Query: 421 PATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKYIINGIYTAEILAIDDGSGKTAT 480
PATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKYIINGIYTAEILAIDDGSGKTAT
Sbjct: 421 PATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKYIINGIYTAEILAIDDGSGKTAT 480
Query: 481 GTICIEVPDINDYCPNIFPERRTICIDSPSVLISVNEHSYGSPFTFCVVDEPPGIADMWD 540
GTICIEVPDINDYCPNIFPERRTICIDSPSVLISVNEHSYGSPFTFCVVDEPPGIADMWD
Sbjct: 481 GTICIEVPDINDYCPNIFPERRTICIDSPSVLISVNEHSYGSPFTFCVVDEPPGIADMWD 540
Query: 541 VRSTNATSAILTAKQVLSPGFYEIPILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGA 600
VRSTNATSAILTAKQVLSPGFYEIPILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGA
Sbjct: 541 VRSTNATSAILTAKQVLSPGFYEIPILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGA 600
Query: 601 AGIYTEDITGDTYGPVTEDQAGVSNVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQP 660
AGIYTEDITGDTYGPVTEDQAGVSNVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQP
Sbjct: 601 AGIYTEDITGDTYGPVTEDQAGVSNVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQP 660
Query: 661 EGLGTRFAPVPEGGEGVMQSWRIEGAHPEDRLFSAYALPGGGGTADGGGSVLGRCALQAT 720
EGLGTRFAPVPEGGEGVMQSWRIEGAHPEDRLFSAYALPGGGGTADGGGSVLGRCALQAT
Sbjct: 661 EGLGTRFAPVPEGGEGVMQSWRIEGAHPEDRLFSAYALPGGGGTADGGGSVLGRCALQAT 720
Query: 721 PALLNQHPPFSEIYTNTYAAGGTVEGGVSGVELNTGMGTAVGLMAAGAAGASGAARKRSS 780
PALLNQHPPFSEIYTNTYAAGGTVEGGVSGVELNTGMGTAVGLMAAGAAGASGAARKRSS
Sbjct: 721 PALLNQHPPFSEIYTNTYAAGGTVEGGVSGVELNTGMGTAVGLMAAGAAGASGAARKRSS 780
Query: 781 TMGTLRDYADADINMAFLDSYFSEKAYAYADEDEGRPANDCLLIYDHEGVGSPVGSIGCC 840
TMGTLRDYADADINMAFLDSYFSEKAYAYADEDEGRPANDCLLIYDHEGVGSPVGSIGCC
Sbjct: 781 TMGTLRDYADADINMAFLDSYFSEKAYAYADEDEGRPANDCLLIYDHEGVGSPVGSIGCC 840
Query: 841 SWIVDDLDESCMETLDPKFRTLAEICLNTEIEPFPSHQACIPISTDLPLLGPNYFVNESS 900
SWIVDDLDESCMETLDPKFRTLAEICLNTEIEPFPSHQACIPISTDLPLLGPNYFVNESS
Sbjct: 841 SWIVDDLDESCMETLDPKFRTLAEICLNTEIEPFPSHQACIPISTDLPLLGPNYFVNESS 900
Query: 901 GLTPSEVEFQEEMAASEPVVHGDIIVTETYGNADPCVQPTTIIFDPQLAPNVVVTEAVMA 960
GLTPSEVEFQEEMAASEPVVHGDIIVTETYGNADPCVQPTTIIFDPQLAPNVVVTEAVMA
Sbjct: 901 GLTPSEVEFQEEMAASEPVVHGDIIVTETYGNADPCVQPTTIIFDPQLAPNVVVTEAVMA 960
Query: 961 PVYDIQGNICVPAELADYNNVIYAERVLASPGVPDMSNSSTTEGCMGPVMSGNILVGPEI 1020
PVYDIQGNICVPAELADYNNVIYAERVLASPGVPDMSNSSTTEGCMGPVMSGNILVGPEI
Sbjct: 961 PVYDIQGNICVPAELADYNNVIYAERVLASPGVPDMSNSSTTEGCMGPVMSGNILVGPEI 1020
Query: 1021 QVMQMMSPDLPIGQTVGSTSPMTSRHRVTRYSNIHYTQQ 1059
QVMQMMSPDLPIGQTVGSTSPMTSRHRVTRYSNIHYTQQ
Sbjct: 1021 QVMQMMSPDLPIGQTVGSTSPMTSRHRVTRYSNIHYTQQ 1059
>gi|29789445 desmoglein 4 isoform 2 [Homo sapiens]
Length = 1040
Score = 2053 bits (5319), Expect = 0.0
Identities = 1023/1059 (96%), Positives = 1024/1059 (96%), Gaps = 19/1059 (1%)
Query: 1 MDWLFFRNICLLIILMVVMEVNSEFIVEVKEFDIENGTTKWQTVRRQKREWIKFAAACRE 60
MDWLFFRNICLLIILMVVMEVNSEFIVEVKEFDIENGTTKWQTVRRQKREWIKFAAACRE
Sbjct: 1 MDWLFFRNICLLIILMVVMEVNSEFIVEVKEFDIENGTTKWQTVRRQKREWIKFAAACRE 60
Query: 61 GEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTINPRTGEINITSVVDREIT 120
GEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTINPRTGEINITSVVDREIT
Sbjct: 61 GEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTINPRTGEINITSVVDREIT 120
Query: 121 PLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQSVYTASIEENSDANTLVVKLC 180
PLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQSVYTASIEENSDANTLVVKLC
Sbjct: 121 PLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQSVYTASIEENSDANTLVVKLC 180
Query: 181 ATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEVCTMSSFLDREQHSMYNLVVRGS 240
ATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEVCTMSSFLDREQHSMYNLVVRGS
Sbjct: 181 ATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEVCTMSSFLDREQHSMYNLVVRGS 240
Query: 241 DRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENCLSSELIRLQAIDLDEEGT 300
DRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENCLSSELIRLQAIDLDEEGT
Sbjct: 241 DRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENCLSSELIRLQAIDLDEEGT 300
Query: 301 DNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQAPNIQLSIGVKNQADFHYS 360
DNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQAPNIQLSIGVKNQADFHYS
Sbjct: 301 DNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQAPNIQLSIGVKNQADFHYS 360
Query: 361 VASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKGSSLLNYVLGTYTAIDLDTGN 420
VASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKGSSLLNYVLGTYTAIDLDTGN
Sbjct: 361 VASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKGSSLLNYVLGTYTAIDLDTGN 420
Query: 421 PATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKYIINGIYTAEILAIDDGSGKTAT 480
PATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKYIINGIYTAEILAIDDGSGKTAT
Sbjct: 421 PATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKYIINGIYTAEILAIDDGSGKTAT 480
Query: 481 GTICIEVPDINDYCPNIFPERRTICIDSPSVLISVNEHSYGSPFTFCVVDEPPGIADMWD 540
GTICIEVPDINDYCPNIFPERRTICIDSPSVLISVNEHSYGSPFTFCVVDEPPGIADMWD
Sbjct: 481 GTICIEVPDINDYCPNIFPERRTICIDSPSVLISVNEHSYGSPFTFCVVDEPPGIADMWD 540
Query: 541 VRSTNATSAILTAKQVLSPGFYEIPILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGA 600
VRSTNATSAILTAKQVLSPGFYEIPILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGA
Sbjct: 541 VRSTNATSAILTAKQVLSPGFYEIPILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGA 600
Query: 601 AGIYTEDITGDTYGPVTEDQAGVSNVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQP 660
AGIYTEDITGDTYGPVTEDQAGVSNVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQP
Sbjct: 601 AGIYTEDITGDTYGPVTEDQAGVSNVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQP 660
Query: 661 EGLGTRFAPVPEGGEGVMQSWRIEGAHPEDRLFSAYALPGGGGTADGGGSVLGRCALQAT 720
EGLGTRFAPVPEGGEGVMQSWRIEGAHPEDR S P T
Sbjct: 661 EGLGTRFAPVPEGGEGVMQSWRIEGAHPEDRDVSNICAP-------------------MT 701
Query: 721 PALLNQHPPFSEIYTNTYAAGGTVEGGVSGVELNTGMGTAVGLMAAGAAGASGAARKRSS 780
+ SEIYTNTYAAGGTVEGGVSGVELNTGMGTAVGLMAAGAAGASGAARKRSS
Sbjct: 702 ASNTQDRMDSSEIYTNTYAAGGTVEGGVSGVELNTGMGTAVGLMAAGAAGASGAARKRSS 761
Query: 781 TMGTLRDYADADINMAFLDSYFSEKAYAYADEDEGRPANDCLLIYDHEGVGSPVGSIGCC 840
TMGTLRDYADADINMAFLDSYFSEKAYAYADEDEGRPANDCLLIYDHEGVGSPVGSIGCC
Sbjct: 762 TMGTLRDYADADINMAFLDSYFSEKAYAYADEDEGRPANDCLLIYDHEGVGSPVGSIGCC 821
Query: 841 SWIVDDLDESCMETLDPKFRTLAEICLNTEIEPFPSHQACIPISTDLPLLGPNYFVNESS 900
SWIVDDLDESCMETLDPKFRTLAEICLNTEIEPFPSHQACIPISTDLPLLGPNYFVNESS
Sbjct: 822 SWIVDDLDESCMETLDPKFRTLAEICLNTEIEPFPSHQACIPISTDLPLLGPNYFVNESS 881
Query: 901 GLTPSEVEFQEEMAASEPVVHGDIIVTETYGNADPCVQPTTIIFDPQLAPNVVVTEAVMA 960
GLTPSEVEFQEEMAASEPVVHGDIIVTETYGNADPCVQPTTIIFDPQLAPNVVVTEAVMA
Sbjct: 882 GLTPSEVEFQEEMAASEPVVHGDIIVTETYGNADPCVQPTTIIFDPQLAPNVVVTEAVMA 941
Query: 961 PVYDIQGNICVPAELADYNNVIYAERVLASPGVPDMSNSSTTEGCMGPVMSGNILVGPEI 1020
PVYDIQGNICVPAELADYNNVIYAERVLASPGVPDMSNSSTTEGCMGPVMSGNILVGPEI
Sbjct: 942 PVYDIQGNICVPAELADYNNVIYAERVLASPGVPDMSNSSTTEGCMGPVMSGNILVGPEI 1001
Query: 1021 QVMQMMSPDLPIGQTVGSTSPMTSRHRVTRYSNIHYTQQ 1059
QVMQMMSPDLPIGQTVGSTSPMTSRHRVTRYSNIHYTQQ
Sbjct: 1002 QVMQMMSPDLPIGQTVGSTSPMTSRHRVTRYSNIHYTQQ 1040
>gi|119964718 desmoglein 3 preproprotein [Homo sapiens]
Length = 999
Score = 922 bits (2384), Expect = 0.0
Identities = 500/1024 (48%), Positives = 669/1024 (65%), Gaps = 77/1024 (7%)
Query: 4 LFFRNICLLIILMVVMEVNSEFIVEVKEFDIENGTTKWQTVRRQKREWIKFAAACREGED 63
LF R L I +VV+ V+ E +E K E T Q RRQKREW+KFA CREGED
Sbjct: 4 LFPRTTGALAIFVVVILVHGELRIETKGQYDEEEMTMQQAKRRQKREWVKFAKPCREGED 63
Query: 64 NSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTINPRTGEINITSVVDREITPLF 123
NSKRNPIAKI SD ++ QKITYRISGVGID+PP+G+F ++ TG+INIT++VDRE TP F
Sbjct: 64 NSKRNPIAKITSDYQATQKITYRISGVGIDQPPFGIFVVDKNTGDINITAIVDREETPSF 123
Query: 124 LIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQSVYTASIEENSDANTLVVKLCATD 183
LI CRALN++G D+E+PL L VK++DINDN PVFSQ ++ IEENS +N+LV+ L ATD
Sbjct: 124 LITCRALNAQGLDVEKPLILTVKILDINDNPPVFSQQIFMGEIEENSASNSLVMILNATD 183
Query: 184 ADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEVCTMSSFLDREQHSMYNLVVRGSDRD 243
ADE NHLNSKIA+KIVSQEP+G PMF+L+R TGEV T+++ LDREQ S Y LVV G+D+D
Sbjct: 184 ADEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDREQASSYRLVVSGADKD 243
Query: 244 GAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENCLSSELIRLQAIDLDEEGTDNW 303
G +GLS++C+C IKV DVNDNFP + YSA IEEN LSSEL+R Q DLDEE TDNW
Sbjct: 244 G--EGLSTQCECNIKVKDVNDNFPMFRDSQYSARIEENILSSELLRFQVTDLDEEYTDNW 301
Query: 304 LAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQAPNIQLSIGVKNQADFHYSVAS 363
LA Y SGN+GNWF+IQTDP+TNEGILKVVK LDYEQ +++LSI VKN+A+FH SV S
Sbjct: 302 LAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYEQLQSVKLSIAVKNKAEFHQSVIS 361
Query: 364 QFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKGSSLLNYVLGTYTAIDLDTGNPAT 423
++++ TPV IQV++VREG AF P++ F+V++GI L++Y+LGTY AID DT A+
Sbjct: 362 RYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGISSKKLVDYILGTYQAIDEDTNKAAS 421
Query: 424 DVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKYIINGIYTAEILAIDDGSGKTATGTI 483
+V+Y++G + G +L IDS+T EI+F + ++ S +I+N TAE+LAID+ +GKT+TGT+
Sbjct: 422 NVKYVMGRNDGGYLMIDSKTAEIKFVKNMNRDSTFIVNKTITAEVLAIDEYTGKTSTGTV 481
Query: 484 CIEVPDINDYCPNIFPERRTICIDSPSVLISVN--EHSYGSPFTFCVVDEPPGIADMWDV 541
+ VPD ND CP E+ +C SPSV++S + Y P+TF + D+P + +W +
Sbjct: 482 YVRVPDFNDNCPTAVLEKDAVCSSSPSVVVSARTLNNRYTGPYTFALEDQPVKLPAVWSI 541
Query: 542 RSTNATSAILTAKQVLSPGFYEIPILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGAA 601
+ NATSA+L A++ + PG Y I +++ DS N CE+ + + L C CD+ +C S
Sbjct: 542 TTLNATSALLRAQEQIPPGVYHISLVLTDSQNNRCEMPRSLTLEVCQCDNRGICGTS--- 598
Query: 602 GIYTEDITGDTYGPVTEDQAGVSNVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQPE 661
Y G YG + LGPA IG+++LG+LLL+LAPLLLL C C
Sbjct: 599 --YPTTSPGTRYGRPHSGR-------LGPAAIGLLLLGLLLLLLAPLLLLTCDCGAGSTG 649
Query: 662 GLGTRFAPVPEGGEGVMQSWRIEGAHPEDRLFSAYALPGGGGTADGGGSVLGRCALQATP 721
G+ F PVP+G EG + W IEGAHPED+ + +P TA+G +
Sbjct: 650 GVTGGFIPVPDGSEGTIHQWGIEGAHPEDKEITNICVP--PVTANGADFM---------- 697
Query: 722 ALLNQHPPFSEIYTNTYAAGGTVEGGVSGVELNTGMGTA-------------VGLMAAG- 767
SE+ TNTYA G VE G SG+E+ T +G A V A+G
Sbjct: 698 -------ESSEVCTNTYARGTAVE-GTSGMEMTTKLGAATESGGAAGFATGTVSGAASGF 749
Query: 768 ---------AAGASGAARKRSSTMGTLRDYADADINMAFLDSYFSEKAYAYADEDEGRPA 818
++G SG R R ST GT +DYAD I+M FLDSYFS+KA+A A+ED+G+ A
Sbjct: 750 GAATGVGICSSGQSGTMRTRHSTGGTNKDYADGAISMNFLDSYFSQKAFACAEEDDGQEA 809
Query: 819 NDCLLIYDHEG---VGSPVGSIGCCSWIVDDLDESCMETLDPKFRTLAEICLNT-----E 870
NDCLLIYD+EG GSPVGS+GCCS+I DDLD+S +++L PKF+ LAEI L E
Sbjct: 810 NDCLLIYDNEGADATGSPVGSVGCCSFIADDLDDSFLDSLGPKFKKLAEISLGVDGEGKE 869
Query: 871 IEPFPSHQACIPI-STDLPL-LGPNYFV-------NESSGLTPSEVEFQEEMAASEPVVH 921
++P PS + I S P+ + FV ++ + + Q ++ +P+ H
Sbjct: 870 VQP-PSKDSGYGIESCGHPIEVQQTGFVKCQTLSGSQGASALSTSGSVQPAVSIPDPLQH 928
Query: 922 GDIIVTETYGNADPCVQPTTIIFDPQLAPNVVVTEAVMAPVYDIQGNICVPAELADYNNV 981
G+ +VTETY + VQP+T FDP L NV+VTE V+ P+ + GN+ P +L + +
Sbjct: 929 GNYLVTETYSASGSLVQPSTAGFDPLLTQNVIVTERVICPISSVPGNLAGPTQLRGSHTM 988
Query: 982 IYAE 985
+ E
Sbjct: 989 LCTE 992
>gi|116534898 desmoglein 2 preproprotein [Homo sapiens]
Length = 1118
Score = 615 bits (1587), Expect = e-176
Identities = 394/1038 (37%), Positives = 567/1038 (54%), Gaps = 109/1038 (10%)
Query: 12 LIILMVVMEVNSEFIVEVKEFDIENGTT-KWQTVRRQKREWIKFAAACREGEDNSKRNPI 70
L++L++ V S ++V EN K + RQKR WI A REGED SK+NPI
Sbjct: 11 LLLLLICFNVGSGLHLQVLSTRNENKLLPKHPHLVRQKRAWITAPVALREGEDLSKKNPI 70
Query: 71 AKIRSDC--ESNQKITYRISGVGIDRPPYGVFTINPRTGEINITSVVDREITPLFLIYCR 128
AKI SD E KITY+ +G GI PP+G+F N TGE+N+TS++DRE TP FL+
Sbjct: 71 AKIHSDLAEERGLKITYKYTGKGITEPPFGIFVFNKDTGELNVTSILDREETPFFLLTGY 130
Query: 129 ALNSRGEDLERPLELRVKVMDINDNAPVFSQSVYTASIEENSDANTLVVKLCATDADEEN 188
AL++RG ++E+PLELR+KV+DINDN PVF+Q V+ S+EE S A+TLV+K+ ATDADE N
Sbjct: 131 ALDARGNNVEKPLELRIKVLDINDNEPVFTQDVFVGSVEELSAAHTLVMKINATDADEPN 190
Query: 189 HLNSKIAYKIVSQEPSGAPMFILNRYTGEVCTMSSFLDREQHSMYNLVVRGSDRDG-AAD 247
LNSKI+Y+IVS EP+ P+F LN+ TGE+ T S LDRE+HS Y L V D +G D
Sbjct: 191 TLNSKISYRIVSLEPAYPPVFYLNKDTGEIYTTSVTLDREEHSSYTLTVEARDGNGEVTD 250
Query: 248 GLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENCLSSELIRLQAIDLDEEGTDNWLAQY 307
+ +I++LDVNDN P +E +EEN ++ E+ R++ D DE G+DNWLA +
Sbjct: 251 KPVKQAQVQIRILDVNDNIPVVENKVLEGMVEENQVNVEVTRIKVFDADEIGSDNWLANF 310
Query: 308 LILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQAPNIQLSIGVKNQADFHYSVASQFQM 367
SGN+G +F I+TD QTNEGI+ ++K +DYE+ N+ S+ V N+A FH S+ S+++
Sbjct: 311 TFASGNEGGYFHIETDAQTNEGIVTLIKEVDYEEMKNLDFSVIVANKAAFHKSIRSKYKP 370
Query: 368 HPTPVRIQVVDVREGPAFHPSTMAFSVREGIKGSSLLNYVLGTYTAIDLDTGNPATDVRY 427
P P++++V +V+EG F S ++ V E + SS ++G + A D DTG PA RY
Sbjct: 371 TPIPIKVKVKNVKEGIHFKSSVISIYVSESMDRSS-KGQIIGNFQAFDEDTGLPA-HARY 428
Query: 428 IIGHDAGSWLKIDSRTGEIQFSREFDKKSKYIINGIYTAEILAI-DDGSGKTATGTICIE 486
+ D +W+ +DS T EI+ ++ D +S+Y+ NG YT +I+AI +D KT TGT+ I
Sbjct: 429 VKLEDRDNWISVDSVTSEIKLAKLPDFESRYVQNGTYTVKIVAISEDYPRKTITGTVLIN 488
Query: 487 VPDINDYCPNIFPERRTICIDSPSVLISVNE---HSYGSPFTFCVVDEPPGIADMWDVRS 543
V DIND CP + +TIC D+ V ++ + H PF+F V+D+PPG+A+ W +
Sbjct: 489 VEDINDNCPTLIEPVQTICHDAEYVNVTAEDLDGHPNSGPFSFSVIDKPPGMAEKWKIAR 548
Query: 544 TNATSAILTAKQVLSPGFYEIPILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGAAGI 603
+TS +L + G EI L+ D+ +C Q++ L C+C C
Sbjct: 549 QESTSVLLQQSE-KKLGRSEIQFLISDNQGFSCPEKQVLTLTVCECLHGSGC-------- 599
Query: 604 YTEDITGDTYGPVTEDQAGVSNVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQPEGL 663
+ D+Y VGLGPA I +M+L LLL+L PLLLL+C C G
Sbjct: 600 --REAQHDSY------------VGLGPAAIALMILAFLLLLLVPLLLLMCHC------GK 639
Query: 664 GTR-FAPVPEGGEGVMQSWRIEGAHPEDRLFSAYALPGGGGTADGGGSVLGRCALQATPA 722
G + F P+P G ++ W EGA PED++ ++ LP D GGS++GR +
Sbjct: 640 GAKGFTPIP-GTIEMLHPWNNEGAPPEDKVVPSF-LP-----VDQGGSLVGRNGVGGMA- 691
Query: 723 LLNQHPPFSEIYTNTYAAGGTVEGGVSGVELNTGMGTAVGLMAAGA---AGASGA----- 774
E ++ V+G E++ L++ A GA+GA
Sbjct: 692 --------KEATMKGSSSASIVKGQHEMSEMDGRWEEHRSLLSGRATQFTGATGAIMTTE 743
Query: 775 ARKRSSTMGTLRDYADAD-----INMAFLDSYFSEKAYAYADEDEGRPANDCLLIYDHEG 829
K + G RD A A +N FL +YF++KA +Y +EDE A DCLL+Y E
Sbjct: 744 TTKTARATGASRDMAGAQAAAVALNEEFLRNYFTDKAASYTEEDENHTAKDCLLVYSQEE 803
Query: 830 VGSPVGSIGCCSWIVDDLDESCMETLDPKFRTLAEICL------NTEIEP---------- 873
S SIGCCS+I +LD+ ++ L KF+TLAE+CL N EIE
Sbjct: 804 TESLNASIGCCSFIEGELDDRFLDDLGLKFKTLAEVCLGQKIDINKEIEQRQKPATETSM 863
Query: 874 -FPSHQAC---IPISTDLPLLGPNYFVNESSGLTPSEVEFQE---EMAAS---------- 916
SH C + S + G ++ V +S +E QE E + S
Sbjct: 864 NTASHSLCEQTMVNSENTYSSGSSFPVPKSLQEANAEKVTQEIVTERSVSSRQAQKVATP 923
Query: 917 --EPVVHGDIIVTETYGNADPCVQPTTIIFDPQLAPNVVVTEAVMAPVYDIQGNICVPAE 974
+P+ ++I TET + PTT+I P +++VTE V AP + V
Sbjct: 924 LPDPMASRNVIATETSYVTGSTMPPTTVILGPSQPQSLIVTERVYAP-----ASTLVDQP 978
Query: 975 LADYNNVIYAERVLASPG 992
A+ V+ ERV+ G
Sbjct: 979 YANEGTVVVTERVIQPHG 996
Score = 33.9 bits (76), Expect = 0.83
Identities = 31/122 (25%), Positives = 52/122 (42%), Gaps = 35/122 (28%)
Query: 937 VQPTTIIFDPQLAPNVVVTEAVMAPVYDIQGNICVPAELADYNNVIYAERVLASPGVPDM 996
VQPT + + + NV VTE V+AP +Q + +P E N++ ++ GVP
Sbjct: 1029 VQPTLAMPNIAVGQNVTVTERVLAPASTLQSSYQIPTE----NSMTARNTTVSGAGVP-- 1082
Query: 997 SNSSTTEGCMGPVMSGNILVGPEIQVMQMMSPDLPIGQTVGSTSPM-TSRHRVTRYSNIH 1055
GP+ PD + ++ S S + TS RVT++S +
Sbjct: 1083 ----------GPL------------------PDFGLEESGHSNSTITTSSTRVTKHSTVQ 1114
Query: 1056 YT 1057
++
Sbjct: 1115 HS 1116
>gi|119703744 desmoglein 1 preproprotein [Homo sapiens]
Length = 1049
Score = 605 bits (1560), Expect = e-173
Identities = 291/503 (57%), Positives = 385/503 (76%), Gaps = 5/503 (0%)
Query: 1 MDWLFFRNICLLIILMVVMEVNSEFIVEVKEFDIENGTTKWQTVRRQKREWIKFAAACRE 60
MDW FFR + +L I +VV+EVNSEF ++V++++ +NGT KW ++RRQKREWIKFAAACRE
Sbjct: 1 MDWSFFRVVAMLFIFLVVVEVNSEFRIQVRDYNTKNGTIKWHSIRRQKREWIKFAAACRE 60
Query: 61 GEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTINPRTGEINITSVVDREIT 120
GEDNSKRNPIAKI SDC +NQ++TYRISGVGID+PPYG+F IN +TGEINITS+VDRE+T
Sbjct: 61 GEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIFVINQKTGEINITSIVDREVT 120
Query: 121 PLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQSVYTASIEENSDANTLVVKLC 180
P F+IYCRALNS G+DLERPLELRV+V+DINDN PVFS + + IEENS+ANTLV+ L
Sbjct: 121 PFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMATFAGQIEENSNANTLVMILN 180
Query: 181 ATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEVCTMSSFLDREQHSMYNLVVRGS 240
ATDADE N+LNSKIA+KI+ QEPS +PMFI+NR TGE+ TM++FLDREQ+ Y L VRGS
Sbjct: 181 ATDADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDREQYGQYALAVRGS 240
Query: 241 DRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENCLSSELIRLQAIDLDEEGT 300
DRDG ADG+S+EC+C IK+LDVNDN P +E++SY+ I+EN L+S L+ ++ IDLDEE +
Sbjct: 241 DRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQENTLNSNLLEIRVIDLDEEFS 300
Query: 301 DNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQAPNIQLSIGVKNQADFHYS 360
NW+A +SGN+GNWF+I+ + +TN GILKVVK LDYE ++QLSIGV+N+A+FH+S
Sbjct: 301 ANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAMQSLQLSIGVRNKAEFHHS 360
Query: 361 VASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKGSSLLNYVLGTYTAIDLDTGN 420
+ SQ+++ + + + V++V EGP F P + + V G GS N +G + A DLDTG
Sbjct: 361 IMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVV-TGNMGS---NDKVGDFVATDLDTGR 416
Query: 421 PATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKYIINGIYTAEILAIDDGSGKTAT 480
P+T VRY++G++ L +DSRTG++ + K+ ++ G Y IL+IDD +T T
Sbjct: 417 PSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGKYQGTILSIDDNLQRTCT 476
Query: 481 GTICIEVPDI-NDYCPNIFPERR 502
GTI I + ND N P +
Sbjct: 477 GTININIQSFGNDDRTNTEPNTK 499
Score = 257 bits (657), Expect = 4e-68
Identities = 278/1023 (27%), Positives = 441/1023 (43%), Gaps = 208/1023 (20%)
Query: 191 NSKIAYKI----VSQEPSGAPMFILNRYTGEVCTMSSFLDREQHSMYNLVVRGSDRDGAA 246
N ++ Y+I + Q P G +F++N+ TGE+ ++S +DRE + + R + G
Sbjct: 80 NQQVTYRISGVGIDQPPYG--IFVINQKTGEI-NITSIVDREVTPFFIIYCRALNSMG-- 134
Query: 247 DGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENCLSSELIR-LQAIDLDEEGTDNWLA 305
L + R++VLD+NDN P +++ IEEN ++ L+ L A D DE N
Sbjct: 135 QDLERPLELRVRVLDINDNPPVFSMATFAGQIEENSNANTLVMILNATDADEPNNLNSKI 194
Query: 306 QYLIL--SGNDGNWFDIQTDPQTNEGILKVVK-MLDYEQAPNIQLSIGVKNQADFHYSVA 362
+ I+ +D F I N G ++ + LD EQ L++ ++ ++
Sbjct: 195 AFKIIRQEPSDSPMFIINR----NTGEIRTMNNFLDREQYGQYALAVRGSDRDGGADGMS 250
Query: 363 SQFQMHPTPVRIQVVDVREG-PAFHPSTMAFSVREGIKGSSLLNYVLGTYTAIDLDTGNP 421
++ + + I+++DV + P S+ ++E S+LL IDLD
Sbjct: 251 AECECN-----IKILDVNDNIPYMEQSSYTIEIQENTLNSNLLEI-----RVIDLDEEFS 300
Query: 422 AT--DVRYIIGHDAGSW--LKIDSRT--GEIQFSREFDKKSKYIIN---GIYT-AEILAI 471
A V + I + G+W ++++ RT G ++ + D ++ + G+ AE
Sbjct: 301 ANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAMQSLQLSIGVRNKAEFHHS 360
Query: 472 DDGSGKTATGTICIEVPDINDYCPNIFPERRTICI-------DSPSVLISVNEHSYGSPF 524
K I + V ++ + P P +T + D ++ + + G P
Sbjct: 361 IMSQYKLKASAISVTVLNVIEG-PVFRPGSKTYVVTGNMGSNDKVGDFVATDLDT-GRPS 418
Query: 525 TFC--VVDEPPGIADMWDVRSTNATSAILTAKQVLSP-------GFYEIPIL-VKDSYNR 574
T V+ P D+ + ++ + LT K ++ G Y+ IL + D+ R
Sbjct: 419 TTVRYVMGNNPA-----DLLAVDSRTGKLTLKNKVTKEQYNMLGGKYQGTILSIDDNLQR 473
Query: 575 ACELAQMVQLYACDCDD------------NHMCLDSGAAGIYTEDITGDTYGPVTEDQAG 622
C + + + DD N +S ++ Y T V + G
Sbjct: 474 TCTGTININIQSFGNDDRTNTEPNTKITTNTGRQESTSSTNYDTSTTSTDSSQVYSSEPG 533
Query: 623 -------VSNVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQPEGLGTRFAPVPEGGE 675
NV GPAGIG++++G L+L L P L++ C C G F PVPE +
Sbjct: 534 NGAKDLLSDNVHFGPAGIGLLIMGFLVLGLVPFLMICCDCGGAPRSAAG--FEPVPECSD 591
Query: 676 GVMQSWRIEGAHPEDRLFSAYALPGGGGTADGGGSVLGRCALQATPALLNQHPPFSEIYT 735
G + SW +EG PE R + +P + A + + S +YT
Sbjct: 592 GAIHSWAVEGPQPEPRDITT-VIP----------------QIPPDNANIIECIDNSGVYT 634
Query: 736 NTYAAGGTVEGGVSGVELNTGMGTAVGLMAAGAAGA----SGAARKRSSTMGTLRDYADA 791
N Y GG + G E TG G+ +G SG R+ S +R+ +
Sbjct: 635 NEY--GGREMQDLGGGERMTGFELTEGVKTSGMPEICQEYSGTLRRNS-----MRECREG 687
Query: 792 DINMAFLDSYFSEKAYAYADEDEGRPANDCLLIYDHEGVGSPVGSIGCCSWIVDDLDESC 851
+NM F++SYF +KAYAYADEDEGRP+NDCLLIYD EGVGSP GS+GCCS+I +DLD+S
Sbjct: 688 GLNMNFMESYFCQKAYAYADEDEGRPSNDCLLIYDIEGVGSPAGSVGCCSFIGEDLDDSF 747
Query: 852 METLDPKFRTLAEICLNTEIEP-----FP---SHQACIPISTD----------------- 886
++TL PKF+ LA+I L E P +P + C+P T+
Sbjct: 748 LDTLGPKFKKLADISLGKESYPDLDPSWPPQSTEPVCLPQETEPVVSGHPPISPHFGTTT 807
Query: 887 ----------------LPLLGP----NYFVNES----SGLTPSEVEFQEEMAASEPVV-- 920
P+L P N V ES L PS V + AS VV
Sbjct: 808 VISESTYPSGPGVLHPKPILDPLGYGNVTVTESYTTSDTLKPS-VHVHDNRPASNVVVTE 866
Query: 921 -----------HG-----------DIIVTETYGNADPCVQPTTIIFDPQLAPNVVVTEAV 958
HG ++IVTE + + I P+ + NVVVTE V
Sbjct: 867 RVVGPISGADLHGMLEMPDLRDGSNVIVTERVIAPSSSLPTSLTIHHPRESSNVVVTERV 926
Query: 959 MAPVYDIQGNICVPAELADYNNVIYAERVLASPGVPDMSNSSTTEGCMGP---------- 1008
+ P + G++ + ELA+ +NVI ERV++ GV +S ++ G +G
Sbjct: 927 IQPTSGMIGSLSMHPELANAHNVIVTERVVSGAGVTGISGTTGISGGIGSSGLVGTSMGA 986
Query: 1009 ---VMSGNILVGPEIQVMQM----------MSPDLPIGQTVGSTSPMTSRHRVTRYSNIH 1055
+SG + G I + + S D QT+GS SP T+R R+T+YS +
Sbjct: 987 GSGALSGAGISGGGIGLSSLGGTASIGHMRSSSDHHFNQTIGSASPSTARSRITKYSTVQ 1046
Query: 1056 YTQ 1058
Y++
Sbjct: 1047 YSK 1049
>gi|13435364 desmocollin 2 isoform Dsc2a preproprotein [Homo
sapiens]
Length = 901
Score = 361 bits (927), Expect = 2e-99
Identities = 263/838 (31%), Positives = 390/838 (46%), Gaps = 72/838 (8%)
Query: 39 TKWQTVRRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYG 98
TK + +RR KR W + E + +++SD N I Y I G G+D+ P
Sbjct: 125 TKEKVLRRAKRRWAPIPCSMLENSLGPFPLFLQQVQSDTAQNYTIYYSIRGPGVDQEPRN 184
Query: 99 VFTINPRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFS 158
+F + TG + T VDRE F I A G E PL L +K+ D NDN P+F+
Sbjct: 185 LFYVERDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNYPIFT 244
Query: 159 QSVYTASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEV 218
+ YT +I EN T V ++CATD DE + +++++ Y I+ Q P +F ++ TG +
Sbjct: 245 EETYTFTIFENCRVGTTVGQVCATDKDEPDTMHTRLKYSIIGQVPPSPTLFSMHPTTGVI 304
Query: 219 CTMSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASI 278
T SS LDRE Y L ++ D DG GL + C I + DVND+ PT +TSY S+
Sbjct: 305 TTTSSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSYVTSV 364
Query: 279 EENCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLD 338
EEN + E++R+ D D T NW A Y IL GN+ F I TD +TNEG+L VVK L+
Sbjct: 365 EENTVDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKPLN 424
Query: 339 YEQAPNIQLSIGVKNQADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGI 398
YE+ + L IGV N+A F + + M V + V D EGP +P ++E
Sbjct: 425 YEEKQQMILQIGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENA 484
Query: 399 KGSSLLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKY 458
+ + N Y A D +T ++ +RY D W+ ID TG I+ R D++++
Sbjct: 485 EVGTTSN----GYKAYDPET-RSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLDREAET 539
Query: 459 IINGIYTAEILAIDDGSGKTATGTICIEVPDINDYCPNIFPERRTICIDSPS------VL 512
I NGIY +LA D G G+T TGT+ I + D+ND P F ++T+ I P+ V
Sbjct: 540 IKNGIYNITVLASDQG-GRTCTGTLGIILQDVNDNSP--FIPKKTVIICKPTMSSAEIVA 596
Query: 513 ISVNEHSYGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVLSPGFYEIPILVKDSY 572
+ +E +G PF F + + MW +++ N T+A L+ + G Y +PI V+D
Sbjct: 597 VDPDEPIHGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQNDPPFGSYVVPITVRDRL 656
Query: 573 NRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVSNVGLGPAG 632
+ + V L CDC + C + + G V LG
Sbjct: 657 GMSSVTSLDVTL--CDCITENDCTHR------------------VDPRIGGGGVQLGKWA 696
Query: 633 IGMMVLGILLLILAPLLLLLCCCKQRQPEGLGTRFAPVPEGGEGVMQSWRIEG--AHPED 690
I ++LGI LL +L L C GT P + Q+ + A +D
Sbjct: 697 ILAILLGIALLFC--ILFTLVC------GASGTSKQPKVIPDDLAQQNLIVSNTEAPGDD 748
Query: 691 RLFSAYALPGGGGTADGGGSVLGRCALQATPALLNQHPPFSEIYTNTYAAGGTVEGGVSG 750
+++SA G T G S G C G GG
Sbjct: 749 KVYSA----NGFTTQTVGASAQGVCGT---------------------VGSGIKNGGQET 783
Query: 751 VEL-NTGMGTAVGLMAAGAAGASGAARKRSSTMGTLRDYADADINMAFLDSYFSEKAYAY 809
+E+ G T+ AG + R + + R Y ++ + +F EK Y
Sbjct: 784 IEMVKGGHQTSESCRGAGHHHTLDSCRGGHTEVDNCR-YTYSEWH-SFTQPRLGEKVYLC 841
Query: 810 ADEDEGRPANDCLLIYDHEGVGSPVGSIGCCSWIVDDLDESCMETLDPKFRTLAEICL 867
++ + A D +L Y++EG GS GS+GCCS ++ ++ L+PKFRTLAE C+
Sbjct: 842 NQDENHKHAQDYVLTYNYEGRGSVAGSVGCCSERQEEDGLEFLDNLEPKFRTLAEACM 899
>gi|148539846 desmocollin 3 isoform Dsc3a preproprotein [Homo
sapiens]
Length = 896
Score = 343 bits (879), Expect = 6e-94
Identities = 248/838 (29%), Positives = 387/838 (46%), Gaps = 79/838 (9%)
Query: 39 TKWQTVRRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYG 98
T+ +RR KR W + +E + ++ SD N + Y ISG G+D+ P
Sbjct: 125 TRETVLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVFYSISGRGVDKEPLN 184
Query: 99 VFTINPRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFS 158
+F I TG + T VDRE +F + A + G + PL L ++V D NDN PVF+
Sbjct: 185 LFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFT 244
Query: 159 QSVYTASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEV 218
+++Y + E+S T V +CATD DE + +++++ Y I+ Q P +F ++ TG +
Sbjct: 245 EAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVI 304
Query: 219 CTMSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASI 278
T+S +LDRE Y+L+++ D DG GL C I V D NDN PT + +Y A +
Sbjct: 305 TTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFV 364
Query: 279 EENCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLD 338
EEN + E++R+ D D T NW + IL GN+ F I TD +TNEG+L VVK L+
Sbjct: 365 EENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLN 424
Query: 339 YEQAPNIQLSIGVKNQADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGI 398
YE+ + L IGV N+A F + ++ V + V D+ EGP P+ ++E +
Sbjct: 425 YEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENL 484
Query: 399 KGSSLLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKY 458
S +N Y A D + N +RY HD W+ ID +G I S+ D++ +
Sbjct: 485 AVGSKIN----GYKAYDPENRN-GNGLRYKKLHDPKGWITIDEISGSIITSKILDREVET 539
Query: 459 IINGIYTAEILAIDDGSGKTATGTICIEVPDINDYCPNIFPERRTICID----SPSVLIS 514
N +Y +LAID ++ TGT+ + + D+ND P I E IC + + +
Sbjct: 540 PKNELYNITVLAIDK-DDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVD 598
Query: 515 VNEHSYGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVLSPGFYEIPILVKDSYNR 574
+E +G+PF F + + P I+ +W + N T+A L+ ++ Y IPI VKD +
Sbjct: 599 PDEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQ 658
Query: 575 ACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVSNVGLGPAGIG 634
A +++++ C+C C + + + V LG I
Sbjct: 659 AA--TKLLRVNLCECTHPTQCRATSRS----------------------TGVILGKWAIL 694
Query: 635 MMVLGILLLILAPLLLLLC-----CCKQRQPEGLGTRFAPVPEGGEGVMQSWRIEGAHPE 689
++LGI LL + LL L+C +R PE L + + A +
Sbjct: 695 AILLGIALL-FSVLLTLVCGVFGATKGKRFPEDLAQQNLIISN-----------TEAPGD 742
Query: 690 DRLFSAYALPGGGGTADGGGSVLGRCALQATPALLNQHPPFSEIYTNTYAAGGTVEGGVS 749
DR+ SA G T S G C + G GG
Sbjct: 743 DRVCSA----NGFMTQTTNNSSQGFCGTMGS---------------------GMKNGGQE 777
Query: 750 GVE-LNTGMGTAVGLMAAGAAGASGAARKRSSTMGTLRDYADADINMAFLDSYFSEKAYA 808
+E + G T AG + R + + R Y ++ + +F EK +
Sbjct: 778 TIEMMKGGNQTLESCRGAGHHHTLDSCRGGHTEVDNCR-YTYSEWH-SFTQPRLGEKLHR 835
Query: 809 YADEDEGRPANDCLLIYDHEGVGSPVGSIGCCSWIVDDLDESCMETLDPKFRTLAEIC 866
++ P+ D +L Y++EG GSP GS+GCCS ++ + L+PKF TLAE C
Sbjct: 836 CNQNEDRMPSQDYVLTYNYEGRGSPAGSVGCCSEKQEEDGLDFLNNLEPKFITLAEAC 893
>gi|13435361 desmocollin 1 isoform Dsc1a preproprotein [Homo
sapiens]
Length = 894
Score = 333 bits (853), Expect = 7e-91
Identities = 254/838 (30%), Positives = 386/838 (46%), Gaps = 78/838 (9%)
Query: 39 TKWQTVRRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYG 98
TK ++R KR W A+ E + +I+SD N I Y ISG G+D+ P+
Sbjct: 124 TKDTALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNYTIFYSISGPGVDKEPFN 183
Query: 99 VFTINPRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFS 158
+F I TG+I T +DRE F +Y A + G E PL L +K+ D NDNAP F
Sbjct: 184 LFYIEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAPYFE 243
Query: 159 QSVYTASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEV 218
V ++ EN + T V K+ ATD DE + L++++ YKI+ Q P F ++ TG +
Sbjct: 244 HRVTIFTVPENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIPDHPKHFSIHPDTGVI 303
Query: 219 CTMSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASI 278
T + FLDRE+ Y L++ D G GL + I + D NDN P+ +TSY +
Sbjct: 304 TTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEV 363
Query: 279 EENCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLD 338
EEN + E++R++ D D T + A Y IL GN+ F I TDP TNEG+L VVK L+
Sbjct: 364 EENRIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLN 423
Query: 339 YEQAPNIQLSIGVKNQADFHYSVASQF-QMHPTPVRIQVVDVREGPAFHPSTMAFSVREG 397
YE + L +GV N+A F + +SQ M T V ++++D EGP HP ++G
Sbjct: 424 YEVNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDG 483
Query: 398 I-KGSSLLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKS 456
G LL Y A+D + + +RY D +W +I+ TG+++ + D++S
Sbjct: 484 FPAGQELLG-----YKALDPEISS-GEGLRYQKLGDEDNWFEINQHTGDLRTLKVLDRES 537
Query: 457 KYIINGIYTAEILAIDDGSGKTATGTICIEVPDINDYCPNIFPERRTICIDSP--SVLIS 514
K++ N Y ++A+ D G++ TGT+ + + D ND+ P I E TIC ++ +VL
Sbjct: 538 KFVKNNQYNISVVAV-DAVGRSCTGTLVVHLDDYNDHAPQIDKE-VTICQNNEDFAVLKP 595
Query: 515 VNEH--SYGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVLSPGFYEIPILVKDSY 572
V+ G PF F + + + W++ + +AIL +Q L +Y +PI +KD +
Sbjct: 596 VDPDGPENGPPFQFFLDN---SASKNWNIEEKDGKTAILRQRQNLDYNYYSVPIQIKDRH 652
Query: 573 NRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVSNVGLGPAG 632
M+ + CDC C + T D+ NV LG
Sbjct: 653 GLVA--THMLTVRVCDCSTPSECRMKDKS---TRDVR--------------PNVILGRWA 693
Query: 633 IGMMVLGILLLILAPLLLLLCCCKQRQPEGLGTRFAPVPEGGEGVMQSWRIEGAHPEDRL 692
I MVLG +LL+ +L C C V ++ PED
Sbjct: 694 ILAMVLGSVLLL---CILFTCFC---------------------VTAKRTVKKCFPEDIA 729
Query: 693 FSAYALPGGGGTADGGGSVLGRCALQATPALLNQHPPFSEIYTNTYAAGGTVEGGVSGVE 752
+ G + + T A + S I +T + GTV G G++
Sbjct: 730 QQNLIVSNTEGPGE-----------EVTEANIRLPMQTSNI-CDTSMSVGTVGG--QGIK 775
Query: 753 LNTGMGTAVG---LMAAGAAGASGAARKRSSTMGTLRDYADADINMAFLDSYFSEKAYAY 809
G L + G + G YA D +F EK Y
Sbjct: 776 TQQSFEMVKGGYTLDSNKGGGHQTLESVKGVGQGDTGRYAYTDW-QSFTQPRLGEKVYLC 834
Query: 810 ADEDEGRPANDCLLIYDHEGVGSPVGSIGCCSWIVDDLDESCMETLDPKFRTLAEICL 867
++E + D + Y++EG GS GS+GCCS ++ ++ L+PKFRTLA+ C+
Sbjct: 835 GQDEEHKHCEDYVCSYNYEGKGSLAGSVGCCSDRQEEEGLEFLDHLEPKFRTLAKTCI 892
>gi|13435366 desmocollin 2 isoform Dsc2b preproprotein [Homo
sapiens]
Length = 847
Score = 320 bits (820), Expect = 4e-87
Identities = 210/621 (33%), Positives = 307/621 (49%), Gaps = 35/621 (5%)
Query: 39 TKWQTVRRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYG 98
TK + +RR KR W + E + +++SD N I Y I G G+D+ P
Sbjct: 125 TKEKVLRRAKRRWAPIPCSMLENSLGPFPLFLQQVQSDTAQNYTIYYSIRGPGVDQEPRN 184
Query: 99 VFTINPRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFS 158
+F + TG + T VDRE F I A G E PL L +K+ D NDN P+F+
Sbjct: 185 LFYVERDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNYPIFT 244
Query: 159 QSVYTASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEV 218
+ YT +I EN T V ++CATD DE + +++++ Y I+ Q P +F ++ TG +
Sbjct: 245 EETYTFTIFENCRVGTTVGQVCATDKDEPDTMHTRLKYSIIGQVPPSPTLFSMHPTTGVI 304
Query: 219 CTMSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASI 278
T SS LDRE Y L ++ D DG GL + C I + DVND+ PT +TSY S+
Sbjct: 305 TTTSSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSYVTSV 364
Query: 279 EENCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLD 338
EEN + E++R+ D D T NW A Y IL GN+ F I TD +TNEG+L VVK L+
Sbjct: 365 EENTVDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKPLN 424
Query: 339 YEQAPNIQLSIGVKNQADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGI 398
YE+ + L IGV N+A F + + M V + V D EGP +P ++E
Sbjct: 425 YEEKQQMILQIGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENA 484
Query: 399 KGSSLLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKY 458
+ + N Y A D +T ++ +RY D W+ ID TG I+ R D++++
Sbjct: 485 EVGTTSN----GYKAYDPET-RSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLDREAET 539
Query: 459 IINGIYTAEILAIDDGSGKTATGTICIEVPDINDYCPNIFPERRTICIDSPS------VL 512
I NGIY +LA D G G+T TGT+ I + D+ND P F ++T+ I P+ V
Sbjct: 540 IKNGIYNITVLASDQG-GRTCTGTLGIILQDVNDNSP--FIPKKTVIICKPTMSSAEIVA 596
Query: 513 ISVNEHSYGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVLSPGFYEIPILVKDSY 572
+ +E +G PF F + + MW +++ N T+A L+ + G Y +PI V+D
Sbjct: 597 VDPDEPIHGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQNDPPFGSYVVPITVRDRL 656
Query: 573 NRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVSNVGLGPAG 632
+ + V L CDC + C + + G V LG
Sbjct: 657 GMSSVTSLDVTL--CDCITENDCTHR------------------VDPRIGGGGVQLGKWA 696
Query: 633 IGMMVLGILLLILAPLLLLLC 653
I ++LGI LL L L+C
Sbjct: 697 ILAILLGIALLFCI-LFTLVC 716
>gi|14589893 cadherin 4, type 1 preproprotein [Homo sapiens]
Length = 916
Score = 313 bits (803), Expect = 4e-85
Identities = 198/628 (31%), Positives = 317/628 (50%), Gaps = 39/628 (6%)
Query: 44 VRRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTIN 103
+RR+KR+W+ E + +IRSD +++ I Y I+GVG D+PP VF+I+
Sbjct: 164 LRRRKRDWVIPPINVPENSRGPFPQQLVRIRSDKDNDIPIRYSITGVGADQPPMEVFSID 223
Query: 104 PRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQSVYT 163
+G + +T +DRE + + A++ G +E P++L + V+D+NDN P F VY
Sbjct: 224 SMSGRMYVTRPMDREEHASYHLRAHAVDMNGNKVENPIDLYIYVIDMNDNRPEFINQVYN 283
Query: 164 ASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEPSGAP--MFILNRYTGEVCTM 221
S++E S T V+ + A DAD+ N + Y+IV+Q P MF +N TG++ T+
Sbjct: 284 GSVDEGSKPGTYVMTVTANDADDSTTANGMVRYRIVTQTPQSPSQNMFTINSETGDIVTV 343
Query: 222 SSFLDREQHSMYNLVVRGSDRDGAAD-GLSSECDCRIKVLDVNDNFPTLEKTSYSASIEE 280
++ LDRE+ Y ++V+ +D +G + GLS+ I V DVNDN P ++++ + E
Sbjct: 344 AAGLDREKVQQYTVIVQATDMEGNLNYGLSNTATAIITVTDVNDNPPEFTASTFAGEVPE 403
Query: 281 NCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYE 340
N + + + L +D D+ + NW A Y I+SG+ F ++TDP TNEG++ VVK +DYE
Sbjct: 404 NRVETVVANLTVMDRDQPHSPNWNAVYRIISGDPSGHFSVRTDPVTNEGMVTVVKAVDYE 463
Query: 341 QAPNIQLSIGVKNQADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKG 400
L++ V NQA + FQ V I ++D+ E P F + + EG+
Sbjct: 464 LNRAFMLTVMVSNQAPLASGIQMSFQ-STAGVTISIMDINEAPYFPSNHKLIRLEEGVPP 522
Query: 401 SSLLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKYII 460
+ VL T++A+D D VRY D SWL I++ G+I + D++S Y
Sbjct: 523 GT----VLTTFSAVDPDRFMQQA-VRYSKLSDPASWLHINATNGQITTAAVLDRESLYTK 577
Query: 461 NGIYTAEILAIDDG-SGKTATGTICIEVPDINDYCPNIFPERRTICIDSPSVLISVNEHS 519
N +Y A LA D+G + TGT+ I + DIND P + P+ IC I++
Sbjct: 578 NNVYEATFLAADNGIPPASGTGTLQIYLIDINDNAPELLPKEAQICEKPNLNAINITAAD 637
Query: 520 YG-----SPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQV-LSPGFYEIPILVKDSYN 573
P+ F + P + W + N A L+ + + L G Y++PI+V DS N
Sbjct: 638 ADVDPNIGPYVFELPFVPAAVRKNWTITRLNGDYAQLSLRILYLEAGMYDVPIIVTDSGN 697
Query: 574 RACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVSNVGLGPAGI 633
++++ C CDDN C GA V+ GLG I
Sbjct: 698 PPLSNTSIIKVKVCPCDDNGDCTTIGA----------------------VAAAGLGTGAI 735
Query: 634 GMMVLGILLLILAPLLLLLCCCKQRQPE 661
+ +L +L++L +LL + K+R+ E
Sbjct: 736 -VAILICILILLTMVLLFVMWMKRREKE 762
Score = 38.5 bits (88), Expect = 0.034
Identities = 22/65 (33%), Positives = 32/65 (49%), Gaps = 1/65 (1%)
Query: 802 FSEKAYAYADEDEGRPANDCLLIYDHEGVGSPVGSIGCC-SWIVDDLDESCMETLDPKFR 860
F + AD D P D LL++D+EG GS GS+ S D D + P+F+
Sbjct: 845 FINEGLRAADNDPTAPPYDSLLVFDYEGSGSTAGSVSSLNSSSSGDQDYDYLNDWGPRFK 904
Query: 861 TLAEI 865
LA++
Sbjct: 905 KLADM 909
>gi|148539848 desmocollin 3 isoform Dsc3b preproprotein [Homo
sapiens]
Length = 839
Score = 310 bits (794), Expect = 5e-84
Identities = 196/619 (31%), Positives = 308/619 (49%), Gaps = 35/619 (5%)
Query: 39 TKWQTVRRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYG 98
T+ +RR KR W + +E + ++ SD N + Y ISG G+D+ P
Sbjct: 125 TRETVLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVFYSISGRGVDKEPLN 184
Query: 99 VFTINPRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFS 158
+F I TG + T VDRE +F + A + G + PL L ++V D NDN PVF+
Sbjct: 185 LFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFT 244
Query: 159 QSVYTASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEV 218
+++Y + E+S T V +CATD DE + +++++ Y I+ Q P +F ++ TG +
Sbjct: 245 EAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVI 304
Query: 219 CTMSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASI 278
T+S +LDRE Y+L+++ D DG GL C I V D NDN PT + +Y A +
Sbjct: 305 TTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFV 364
Query: 279 EENCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLD 338
EEN + E++R+ D D T NW + IL GN+ F I TD +TNEG+L VVK L+
Sbjct: 365 EENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLN 424
Query: 339 YEQAPNIQLSIGVKNQADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGI 398
YE+ + L IGV N+A F + ++ V + V D+ EGP P+ ++E +
Sbjct: 425 YEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENL 484
Query: 399 KGSSLLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKY 458
S +N Y A D + N +RY HD W+ ID +G I S+ D++ +
Sbjct: 485 AVGSKIN----GYKAYDPENRN-GNGLRYKKLHDPKGWITIDEISGSIITSKILDREVET 539
Query: 459 IINGIYTAEILAIDDGSGKTATGTICIEVPDINDYCPNIFPERRTICID----SPSVLIS 514
N +Y +LAID ++ TGT+ + + D+ND P I E IC + + +
Sbjct: 540 PKNELYNITVLAIDK-DDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVD 598
Query: 515 VNEHSYGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVLSPGFYEIPILVKDSYNR 574
+E +G+PF F + + P I+ +W + N T+A L+ ++ Y IPI VKD +
Sbjct: 599 PDEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQ 658
Query: 575 ACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVSNVGLGPAGIG 634
A +++++ C+C C + + + V LG I
Sbjct: 659 AA--TKLLRVNLCECTHPTQCRATSRS----------------------TGVILGKWAIL 694
Query: 635 MMVLGILLLILAPLLLLLC 653
++LGI LL + LL L+C
Sbjct: 695 AILLGIALL-FSVLLTLVC 712
>gi|14589889 cadherin 2, type 1 preproprotein [Homo sapiens]
Length = 906
Score = 309 bits (791), Expect = 1e-83
Identities = 206/659 (31%), Positives = 319/659 (48%), Gaps = 44/659 (6%)
Query: 24 EFIVEVKEFDIENGTTKWQTVRRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQKI 83
E IV ++F +G ++RQKR+W+ E + +IRSD + N +
Sbjct: 139 EEIVFPRQFSKHSGH-----LQRQKRDWVIPPINLPENSRGPFPQELVRIRSDRDKNLSL 193
Query: 84 TYRISGVGIDRPPYGVFTINPRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLEL 143
Y ++G G D+PP G+F INP +G++++T +DRE F + A++ G +E P+++
Sbjct: 194 RYSVTGPGADQPPTGIFIINPISGQLSVTKPLDREQIARFHLRAHAVDINGNQVENPIDI 253
Query: 144 RVKVMDINDNAPVFSQSVYTASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEP 203
+ V+D+NDN P F V+ ++ E S T V+ + A DAD+ N LN + Y+IVSQ P
Sbjct: 254 VINVIDMNDNRPEFLHQVWNGTVPEGSKPGTYVMTVTAIDADDPNALNGMLRYRIVSQAP 313
Query: 204 S--GAPMFILNRYTGEVCTMSSFLDREQHSMYNLVVRGSDRDG-AADGLSSECDCRIKVL 260
S MF +N TG++ T+++ LDRE+ Y L+++ +D +G GLS+ I V
Sbjct: 314 STPSPNMFTINNETGDIITVAAGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITVT 373
Query: 261 DVNDNFPTLEKTSYSASIEENCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDI 320
DVNDN P ++ + EN + + L D D+ T W A Y I G+ F I
Sbjct: 374 DVNDNPPEFTAMTFYGEVPENRVDIIVANLTVTDKDQPHTPAWNAVYRISGGDPTGRFAI 433
Query: 321 QTDPQTNEGILKVVKMLDYEQAPNIQLSIGVKNQADFHYSVASQFQMHPTPVRIQVVDVR 380
QTDP +N+G++ VVK +D+E L++ +NQ + Q T V + V+DV
Sbjct: 434 QTDPNSNDGLVTVVKPIDFETNRMFVLTVAAENQVPLAKGIQHPPQSTAT-VSVTVIDVN 492
Query: 381 EGPAFHPSTMAFSVREGIKGSSLLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKID 440
E P F P+ EG+ ++L T+TA D D ++RY D +WLKID
Sbjct: 493 ENPYFAPNPKIIRQEEGLHAGTMLT----TFTAQDPDR-YMQQNIRYTKLSDPANWLKID 547
Query: 441 SRTGEIQFSREFDKKSKYIINGIYTAEILAIDDG-SGKTATGTICIEVPDINDYCPNIFP 499
G+I D++S + N IY A LA D+G + TGT+ I + DIND P + P
Sbjct: 548 PVNGQITTIAVLDRESPNVKNNIYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVLP 607
Query: 500 ERRTICIDSPSVLISVNEHSY-----GSPFTFCVVDEPPGIADMWDVRSTNATSAILTAK 554
+ C I++ Y PF F + P I W + N A L K
Sbjct: 608 QEAETCETPDPNSINITALDYDIDPNAGPFAFDLPLSPVTIKRNWTITRLNGDFAQLNLK 667
Query: 555 -QVLSPGFYEIPILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTY 613
+ L G YE+PI++ DS N ++++ C CD N C D + I G
Sbjct: 668 IKFLEAGIYEVPIIITDSGNPPKSNISILRVKVCQCDSNGDCTD-------VDRIVG--- 717
Query: 614 GPVTEDQAGVSNVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQPEGLGTRFAPVPE 672
GLG I ++L I++L++ +L+ + K+R E + PE
Sbjct: 718 ------------AGLGTGAIIAILLCIIILLIL-VLMFVVWMKRRDKERQAKQLLIDPE 763
Score = 35.8 bits (81), Expect = 0.22
Identities = 21/66 (31%), Positives = 32/66 (48%), Gaps = 2/66 (3%)
Query: 802 FSEKAYAYADEDEGRPANDCLLIYDHEGVGSPVGSIGC--CSWIVDDLDESCMETLDPKF 859
F + AD D P D LL++D+EG GS GS+ S + D + P+F
Sbjct: 835 FINEGLKAADNDPTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGEQDYDYLNDWGPRF 894
Query: 860 RTLAEI 865
+ LA++
Sbjct: 895 KKLADM 900
>gi|4826702 desmocollin 1 isoform Dsc1b preproprotein [Homo sapiens]
Length = 840
Score = 303 bits (775), Expect = 7e-82
Identities = 206/623 (33%), Positives = 311/623 (49%), Gaps = 39/623 (6%)
Query: 39 TKWQTVRRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYG 98
TK ++R KR W A+ E + +I+SD N I Y ISG G+D+ P+
Sbjct: 124 TKDTALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNYTIFYSISGPGVDKEPFN 183
Query: 99 VFTINPRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFS 158
+F I TG+I T +DRE F +Y A + G E PL L +K+ D NDNAP F
Sbjct: 184 LFYIEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAPYFE 243
Query: 159 QSVYTASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEV 218
V ++ EN + T V K+ ATD DE + L++++ YKI+ Q P F ++ TG +
Sbjct: 244 HRVTIFTVPENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIPDHPKHFSIHPDTGVI 303
Query: 219 CTMSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASI 278
T + FLDRE+ Y L++ D G GL + I + D NDN P+ +TSY +
Sbjct: 304 TTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEV 363
Query: 279 EENCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLD 338
EEN + E++R++ D D T + A Y IL GN+ F I TDP TNEG+L VVK L+
Sbjct: 364 EENRIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLN 423
Query: 339 YEQAPNIQLSIGVKNQADFHYSVASQF-QMHPTPVRIQVVDVREGPAFHPSTMAFSVREG 397
YE + L +GV N+A F + +SQ M T V ++++D EGP HP ++G
Sbjct: 424 YEVNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDG 483
Query: 398 I-KGSSLLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKS 456
G LL Y A+D + + +RY D +W +I+ TG+++ + D++S
Sbjct: 484 FPAGQELLG-----YKALDPEISS-GEGLRYQKLGDEDNWFEINQHTGDLRTLKVLDRES 537
Query: 457 KYIINGIYTAEILAIDDGSGKTATGTICIEVPDINDYCPNIFPERRTICIDSP--SVLIS 514
K++ N Y ++A+ D G++ TGT+ + + D ND+ P I E TIC ++ +VL
Sbjct: 538 KFVKNNQYNISVVAV-DAVGRSCTGTLVVHLDDYNDHAPQIDKE-VTICQNNEDFAVLKP 595
Query: 515 VNEH--SYGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVLSPGFYEIPILVKDSY 572
V+ G PF F + + + W++ + +AIL +Q L +Y +PI +KD +
Sbjct: 596 VDPDGPENGPPFQFFLDN---SASKNWNIEEKDGKTAILRQRQNLDYNYYSVPIQIKDRH 652
Query: 573 NRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVSNVGLGPAG 632
M+ + CDC C + T D+ NV LG
Sbjct: 653 GLVA--THMLTVRVCDCSTPSECRMKDKS---TRDVR--------------PNVILGRWA 693
Query: 633 IGMMVLGILLLILAPLLLLLCCC 655
I MVLG +LL+ +L C C
Sbjct: 694 ILAMVLGSVLLL---CILFTCFC 713
>gi|4826669 cadherin 15 preproprotein [Homo sapiens]
Length = 814
Score = 291 bits (746), Expect = 2e-78
Identities = 199/657 (30%), Positives = 332/657 (50%), Gaps = 45/657 (6%)
Query: 46 RQKREWIKFAAACREGEDNSKR--NPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTIN 103
R +R W+ + E N KR P+ +I+SD + + Y I G G+D P GVF+I+
Sbjct: 42 RVRRAWVIPPISVSE---NHKRLPYPLVQIKSDKQQLGSVIYSIQGPGVDEEPRGVFSID 98
Query: 104 PRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQSVYT 163
TG++ + +++DRE T F + AL+ G LE P +L + V+D NDN P F Q +T
Sbjct: 99 KFTGKVFLNAMLDREKTDRFRLRAFALDLGGSTLEDPTDLEIVVVDQNDNRPAFLQEAFT 158
Query: 164 ASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEPSGAP-MFILNRYTGEVCTMS 222
+ E + T V + ATDAD+ N+ + + I+ Q G+P +F ++ TGE+ T+
Sbjct: 159 GRVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQ---GSPELFSIDELTGEIRTVQ 215
Query: 223 SFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENC 282
LDRE ++YNL ++ +D G DGL++ I + D+NDN P + + E
Sbjct: 216 VGLDREVVAVYNLTLQVADMSG--DGLTATASAIITLDDINDNAPEFTRDEFFMEAIEAV 273
Query: 283 LSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQA 342
++ RL+ D D G+ NW+A++ IL G+ F I+TDP+TNEG+L +VK LDYE
Sbjct: 274 SGVDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDYESC 333
Query: 343 PNIQLSIGVKNQADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKGSS 402
+ +L + V+N+A + A + + VR+ V D E P F + + S+ EG +
Sbjct: 334 EHYELKVSVQNEAPLQ-AAALRAERGQAKVRVHVQDTNEPPVFQENPLRTSLAEGAPPGT 392
Query: 403 LLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKYIING 462
L + T++A D DT + Y +D WL++D+ TG IQ S ++ G
Sbjct: 393 L----VATFSARDPDT-EQLQRLSYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKGG 447
Query: 463 IYTAEILAIDDGS-GKTATGTICIEVPDINDYCPNIF-PERRTICID---SPSVLISVNE 517
Y A +LA DD S +TATGT+ IE+ ++ND+ P + P ++C + P +L+ +
Sbjct: 448 WYRAIVLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQGPGLLLGATD 507
Query: 518 HS---YGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVLSPGFYEIPILVKDSYNR 574
+G+PF F + P + W + N + A L + + G + + +L++DS
Sbjct: 508 EDLPPHGAPFHFQLSPRLPELGRNWSLSQVNVSHARLRPRHQVPEGLHRLSLLLRDSGQP 567
Query: 575 ACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVSNVGLGPAGIG 634
+ Q + + C C + +CL AA + AG + + LG +
Sbjct: 568 PQQREQPLNVTVCRCGKDGVCLPGAAALL-----------------AGGTGLSLG--ALV 608
Query: 635 MMVLGILLLILAPLLLLLCCCKQRQPEGLGTRFAPVPEGGEGVMQSWRIEGAHPEDR 691
+++ LLL++ LL+ L +Q G G P + + V+ ++ +G ED+
Sbjct: 609 IVLASALLLLVLVLLVALRARFWKQSRGKGLLHGPQDDLRDNVL-NYDEQGGGEEDQ 664
Score = 34.7 bits (78), Expect = 0.49
Identities = 21/58 (36%), Positives = 29/58 (50%), Gaps = 2/58 (3%)
Query: 810 ADEDEGRPANDCLLIYDHEGVGSPVGSIG--CCSWIVDDLDESCMETLDPKFRTLAEI 865
AD D P D LIYD+EG GS G++ S +D D + P+F LA++
Sbjct: 722 ADSDPSVPPYDTALIYDYEGDGSVAGTLSSILSSQGDEDQDYDYLRDWGPRFARLADM 779
>gi|4757960 cadherin 1, type 1 preproprotein [Homo sapiens]
Length = 882
Score = 289 bits (739), Expect = 1e-77
Identities = 210/623 (33%), Positives = 317/623 (50%), Gaps = 55/623 (8%)
Query: 44 VRRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTIN 103
+RRQKR+W+ +C E E + +I+S+ + K+ Y I+G G D PP GVF I
Sbjct: 149 LRRQKRDWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTPPVGVFIIE 208
Query: 104 PRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQSVYT 163
TG + +T +DRE + ++ A++S G +E P+E+ + V D NDN P F+Q V+
Sbjct: 209 RETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFK 268
Query: 164 ASIEENSDANTLVVKLCATDADEE-NHLNSKIAYKIVSQEPS--GAPMFILNRYTGEVCT 220
S+ E + T V+++ ATDAD++ N N+ IAY I+SQ+P MF +NR TG +
Sbjct: 269 GSVMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISV 328
Query: 221 MSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEE 280
+++ LDRE Y LVV+ +D G +GLS+ I V D NDN P T+Y + E
Sbjct: 329 VTTGLDRESFPTYTLVVQAADLQG--EGLSTTATAVITVTDTNDNPPIFNPTTYKGQVPE 386
Query: 281 NCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYE 340
N + + L+ D D T W A Y IL+ +DG F + T+P N+GILK K LD+E
Sbjct: 387 NEANVVITTLKVTDADAPNTPAWEAVYTILN-DDGGQFVVTTNPVNNDGILKTAKGLDFE 445
Query: 341 QAPNIQLSIGVKNQADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKG 400
L + V N F S+ + V + V+DV E P F P V E
Sbjct: 446 AKQQYILHVAVTNVVPFEVSLTTS----TATVTVDVLDVNEAPIFVPPEKRVEVSEDFG- 500
Query: 401 SSLLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKS-KYI 459
+ + +YTA + DT + Y I D +WL+I+ TG I E D++ +++
Sbjct: 501 ---VGQEITSYTAQEPDT-FMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHV 556
Query: 460 INGIYTAEILAIDDGSG-KTATGTICIEVPDINDYCPNIFPERRTI--CIDSPSV----L 512
N YTA I+A D+GS T TGT+ + + D+ND P PE RTI C +P +
Sbjct: 557 KNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAP--IPEPRTIFFCERNPKPQVINI 614
Query: 513 ISVNEHSYGSPFTFCVVDEPPGIADMWDVRSTNAT--SAILTAKQVLSPGFYEIPILVKD 570
I + SPFT + G + W ++ + T S IL K L G Y+I + + D
Sbjct: 615 IDADLPPNTSPFT---AELTHGASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLMD 671
Query: 571 SYNRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVSNVGLGP 630
+ N+ + +++ CDC+ GAAG+ + PV +AG+ P
Sbjct: 672 NQNK--DQVTTLEVSVCDCE--------GAAGVCRK------AQPV---EAGLQI----P 708
Query: 631 AGIGMM--VLGILLLILAPLLLL 651
A +G++ +L +L+LIL LL L
Sbjct: 709 AILGILGGILALLILILLLLLFL 731
Score = 32.7 bits (73), Expect = 1.9
Identities = 23/87 (26%), Positives = 40/87 (45%), Gaps = 3/87 (3%)
Query: 781 TMGTLRDYADADINMAFLDSYFSEKAYAYADEDEGRPANDCLLIYDHEGVGSPVGSIGCC 840
T+ ++ Y N + ++ E A AD D P D LL++D+EG GS S+
Sbjct: 790 TLMSVPRYLPRPANPDEIGNFIDENLKA-ADTDPTAPPYDSLLVFDYEGSGSEAASLSSL 848
Query: 841 SWIVDDLDE--SCMETLDPKFRTLAEI 865
+ D D+ + +F+ LA++
Sbjct: 849 NSSESDKDQDYDYLNEWGNRFKKLADM 875
>gi|4502719 cadherin 13 preproprotein [Homo sapiens]
Length = 713
Score = 278 bits (712), Expect = 1e-74
Identities = 183/577 (31%), Positives = 291/577 (50%), Gaps = 34/577 (5%)
Query: 44 VRRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTIN 103
V RQKR + E + + K+ D + ++ +R++G G+D+ P G+F IN
Sbjct: 133 VPRQKRSIVVSPILIPENQRQPFPRDVGKV-VDSDRPERSKFRLTGKGVDQEPKGIFRIN 191
Query: 104 PRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQSVYT 163
TG +++T +DRE+ ++ ++ + G+ LE P+ L V V+D NDN P+F + Y
Sbjct: 192 ENTGSVSVTRTLDREVIAVYQLFVETTDVNGKTLEGPVPLEVIVIDQNDNRPIFREGPYI 251
Query: 164 ASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEPS--GAPMFILNRYTGEVCTM 221
+ E S T V+++ A DAD+ N+ + Y I Q P MF ++ G++ T+
Sbjct: 252 GHVMEGSPTGTTVMRMTAFDADDPATDNALLRYNIRQQTPDKPSPNMFYIDPEKGDIVTV 311
Query: 222 SS--FLDRE--QHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSAS 277
S LDRE ++ Y L++ D G GL+ I + D ND+ P K + A+
Sbjct: 312 VSPALLDRETLENPKYELIIEAQDMAGLDVGLTGTATATIMIDDKNDHSPKFTKKEFQAT 371
Query: 278 IEENCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKML 337
+EE + ++ L D D+ T W A Y I++GN G F+I T+PQTNEG+L VVK L
Sbjct: 372 VEEGAV-GVIVNLTVEDKDDPTTGAWRAAYTIINGNPGQSFEIHTNPQTNEGMLSVVKPL 430
Query: 338 DYEQAPNIQLSIGVKNQ----ADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFS 393
DYE + L I V+N+ D Y +S +H I V+DV EGP F+P M +
Sbjct: 431 DYEISAFHTLLIKVENEDPLVPDVSYGPSSTATVH-----ITVLDVNEGPVFYPDPMMVT 485
Query: 394 VREGIKGSSLLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKIDSRTGEIQFSREFD 453
+E + S VL T A D D+ T +RY + D WL I+ G + + D
Sbjct: 486 RQEDLSVGS----VLLTVNATDPDSLQHQT-IRYSVYKDPAGWLNINPINGTVDTTAVLD 540
Query: 454 KKSKYIINGIYTAEILAIDDGS-GKTATGTICIEVPDINDYCPNIFPERRTICIDSPSVL 512
++S ++ N +YTA LAID G+ T TGT+ I + D+ND P I+P +C D+ ++
Sbjct: 541 RESPFVDNSVYTALFLAIDSGNPPATGTGTLLITLEDVNDNAPFIYPTVAEVCDDAKNLS 600
Query: 513 ISV------NEHSYGSPFTFCVVDEPPGIAD-MWDVRSTNATSAILTAKQVLSPGFYEIP 565
+ + + H PF F + + D +W + N T A+++ Q L+ Y +P
Sbjct: 601 VVILGASDKDLHPNTDPFKFEI--HKQAVPDKVWKISKINNTHALVSLLQNLNKANYNLP 658
Query: 566 ILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGAAG 602
I+V DS +++ C C ++ +D AAG
Sbjct: 659 IMVTDSGKPPMTNITDLRVQVCSCRNSK--VDCNAAG 693
>gi|29570800 cadherin-like 26 isoform a [Homo sapiens]
Length = 832
Score = 274 bits (700), Expect = 4e-73
Identities = 205/721 (28%), Positives = 332/721 (46%), Gaps = 62/721 (8%)
Query: 9 ICLLIILMVVMEVNSEFIVEVKEFDIENGTTK--WQTVRRQKREWIKFAAACREGEDNSK 66
+ LL++L+ +++V+ V+ + D+ T + +Q +RR KR W+ E +
Sbjct: 12 LLLLVLLLWLLQVSIIDSVQQETDDLTKQTKEKIYQPLRRSKRRWVITTLELEEEDPGPF 71
Query: 67 RNPIAKIRSDCESNQKITYRISGVGIDR-PPYGVFTINPR-TGEINITSVVDREITPLFL 124
I ++ ++ N + Y ISG G+D P G+F++ G I + VDRE+TP F
Sbjct: 72 PKLIGELFNNMSYNMSLMYLISGPGVDEYPEIGLFSLEDHENGRIYVHRPVDREMTPSFT 131
Query: 125 IYCRALN-SRGEDLERPLELRVKVMDINDNAPVFSQSVYTASIEENSDANTLVVKLCATD 183
+Y + S G+ ++ L +++ D+ND+AP F + + +++EN A + ++ A D
Sbjct: 132 VYFDVVERSTGKIVDTSLIFNIRISDVNDHAPQFPEKEFNITVQENQSAGQPIFQMLAVD 191
Query: 184 ADEENHLNSKIAYKIVSQEP----SGAPMFILNRYTGEVCTMSSFLDREQHSMYNLVVRG 239
DEEN NS++ Y ++SQ P SG F ++R +GE+ +S LD E + L++R
Sbjct: 192 LDEENTPNSQVLYFLISQTPLLKESG---FRVDRLSGEI-RLSGCLDYETAPQFTLLIRA 247
Query: 240 SDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENCLSSELIRLQAIDLDEEG 299
RD LSS + V + N++ P + +Y I E S ++RL D D
Sbjct: 248 --RDCGEPSLSSTTTVHVDVQEGNNHRPAFTQENYKVQIPEGRASQGVLRLLVQDRDSPF 305
Query: 300 TDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQAPNIQLSIGVKNQADFHY 359
T W A++ IL GN+ FDI TDP+TNEGIL V+K LDYE P L I V+N+ +
Sbjct: 306 TSAWRAKFNILHGNEEGHFDISTDPETNEGILNVIKPLDYETRPAQSLIIVVENEERLVF 365
Query: 360 SVASQFQ-----MHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKGSSLLNYVLGTYTAI 414
+ Q V +QV D + PAFHP + + EG + +L LGT+ A+
Sbjct: 366 CERGKLQPPRKAAASATVSVQVTDANDPPAFHPQSFIVNKEEGARPGTL----LGTFNAM 421
Query: 415 DLDTGNPATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKYIINGIYTAEILAIDDG 474
D P + +RY + HD +W+ +D +G + D++S ++ N Y I A+DDG
Sbjct: 422 D-----PDSQIRYELVHDPANWVSVDKNSGVVITVEPIDRESPHVNNSFYVIIIHAVDDG 476
Query: 475 -SGKTATGTICIEVPDINDYCPNIFPERR--TICIDSPSVLISVNEHS-----YGSPFTF 526
+TATGT+ + + DIND P + P R +C + + + + PFTF
Sbjct: 477 FPPQTATGTLMLFLSDINDNVPTLRPRSRYMEVCESAVHEPLHIEAEDPDLEPFSDPFTF 536
Query: 527 CVVDEPPGIADMWDVRSTNATSAILTAKQVLSPGFYEIPILVKDSYNRACELAQMVQLYA 586
+ + D W + S L + L G Y +P+ + D + Q V +
Sbjct: 537 ELDNTWGNAEDTWKLGRNWGQSVELLTLRSLPRGNYLVPLFIGD--KQGLSQKQTVHVRI 594
Query: 587 CDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVSNVGLGPAGIGMMVLGILLLILA 646
C C C++ + + + G+ L P + L + LL L
Sbjct: 595 CPCASGLTCVE------------------LADAEVGLHVGALFPVCAAFVALAVALLFLL 636
Query: 647 PLLLLL----CCCKQRQPEGLGTRFAPVPEGGEGVMQSWR-IEGAHPEDRLFSAYALPGG 701
+L C EG T E Q+W +EG P + +A A P
Sbjct: 637 RCYFVLEPKRHGCSVSNDEGHQTLVMYNAESKGTSAQTWSDVEGQRPALLICTAAAGPTQ 696
Query: 702 G 702
G
Sbjct: 697 G 697
>gi|14589891 cadherin 3, type 1 preproprotein [Homo sapiens]
Length = 829
Score = 266 bits (679), Expect = 1e-70
Identities = 173/557 (31%), Positives = 284/557 (50%), Gaps = 29/557 (5%)
Query: 44 VRRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTIN 103
+RR KR+W+ + E + +++S+ + + KI Y I+G G D PP GVF +
Sbjct: 102 LRRHKRDWVVAPISVPENGKGPFPQRLNQLKSNKDRDTKIFYSITGPGADSPPEGVFAVE 161
Query: 104 PRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQSVYT 163
TG + + +DRE + ++ A++ G +E P+ + + V D ND+ P F+Q +
Sbjct: 162 KETGWLLLNKPLDREEIAKYELFGHAVSENGASVEDPMNISIIVTDQNDHKPKFTQDTFR 221
Query: 164 ASIEENSDANTLVVKLCATDADEENHL-NSKIAYKIVSQEPSGAP--MFILNRYTGEVCT 220
S+ E T V+++ ATD D+ + N +AY I SQEP MF ++R TG +
Sbjct: 222 GSVLEGVLPGTSVMQVTATDEDDAIYTYNGVVAYSIHSQEPKDPHDLMFTIHRSTGTISV 281
Query: 221 MSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEE 280
+SS LDRE+ Y L ++ +D DG DG ++ +++LD NDN P + Y A + E
Sbjct: 282 ISSGLDREKVPEYTLTIQATDMDG--DGSTTTAVAVVEILDANDNAPMFDPQKYEAHVPE 339
Query: 281 NCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYE 340
N + E+ RL DLD + W A YLI+ G+DG+ F I T P++N+GIL K LD+E
Sbjct: 340 NAVGHEVQRLTVTDLDAPNSPAWRATYLIMGGDDGDHFTITTHPESNQGILTTRKGLDFE 399
Query: 341 QAPNIQLSIGVKNQADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKG 400
L + V N+A F + + + + V DV E P F P + V+EGI
Sbjct: 400 AKNQHTLYVEVTNEAPFVLKLPTS----TATIVVHVEDVNEAPVFVPPSKVVEVQEGIPT 455
Query: 401 SSLLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKK-SKYI 459
+ YTA D D N + Y I D WL +D +G++ D++ +++
Sbjct: 456 GE----PVCVYTAEDPDKEN--QKISYRILRDPAGWLAMDPDSGQVTAVGTLDREDEQFV 509
Query: 460 INGIYTAEILAIDDGS-GKTATGTICIEVPDINDYCPNIFPERRTICIDSP-SVLISVNE 517
N IY +LA+D+GS T TGT+ + + D+ND+ P P + TIC SP ++++ +
Sbjct: 510 RNNIYEVMVLAMDNGSPPTTGTGTLLLTLIDVNDHGPVPEPRQITICNQSPVRQVLNITD 569
Query: 518 HS---YGSPFTFCVVDEPPGIADMWDVRSTN--ATSAILTAKQVLSPGFYEIPILVKDSY 572
+ SPF + D+ +D++ N + +L+ K+ L Y++ + + D
Sbjct: 570 KDLSPHTSPFQAQLTDD----SDIYWTAEVNEEGDTVVLSLKKFLKQDTYDVHLSLSDHG 625
Query: 573 NRACELAQMVQLYACDC 589
N+ E +++ CDC
Sbjct: 626 NK--EQLTVIRATVCDC 640
Score = 31.2 bits (69), Expect = 5.4
Identities = 17/58 (29%), Positives = 29/58 (50%), Gaps = 2/58 (3%)
Query: 810 ADEDEGRPANDCLLIYDHEGVGSPVGSIGCCSWIVDDLDE--SCMETLDPKFRTLAEI 865
A+ D P D LL++D+EG GS S+ + D D+ + +F+ LA++
Sbjct: 765 ANTDPTAPPYDTLLVFDYEGSGSDAASLSSLTSSASDQDQDYDYLNEWGSRFKKLADM 822
>gi|4826673 cadherin 6, type 2 preproprotein [Homo sapiens]
Length = 790
Score = 194 bits (494), Expect = 3e-49
Identities = 179/640 (27%), Positives = 286/640 (44%), Gaps = 62/640 (9%)
Query: 44 VRRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQ-KITYRISGVGIDRPPYGVFTI 102
+ R KR W+ E S + K+ SD + + Y +SG G +F I
Sbjct: 48 LNRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAG----DLFII 103
Query: 103 NPRTGEINITSVVDREITPLFLIYCRALNSR-GEDLERPLELRVKVMDINDNAPVFSQSV 161
N TG+I T +DRE P++++ +A+N R G +E E +K+ DINDN P+F++ V
Sbjct: 104 NENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEV 163
Query: 162 YTASIEENSDANTLVVKLCATDADEENHLNS-KIAYKIVSQEPSGAPMFILNRYTGEVCT 220
YTA++ E SD T VV++ ATDAD+ + NS K+ Y I+ G P F + TG + T
Sbjct: 164 YTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSIL----QGQPYFSVESETGIIKT 219
Query: 221 MSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEE 280
+DRE Y +V++ D G GLS I + DVNDN P +++Y E
Sbjct: 220 ALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPE 279
Query: 281 NCLSSELI-RLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDY 339
+ I R++A D D +N +Y I G + FD+ TD +T EGI+ V K+LD+
Sbjct: 280 SSPPGTPIGRIKASDADV--GENAEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDF 337
Query: 340 EQAPNIQLSIGVKN-QADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGI 398
E+ L + N + + F+ T VRI V DV E P F +RE
Sbjct: 338 EKKKVYTLKVEASNPYVEPRFLYLGPFKDSAT-VRIVVEDVDEPPVFSKLAYILQIRE-- 394
Query: 399 KGSSLLNYVLGTYTAIDLDTG-NPATDVRYIIGH--DAGSWLKIDSRTGEIQFSREFDKK 455
+ +N +G+ TA D D NP V+Y + D IDS G I S+ D++
Sbjct: 395 --DAQINTTIGSVTAQDPDAARNP---VKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRE 449
Query: 456 SKYIINGIYTAEILAIDDGSGKTATGT-ICIEVPDINDYCPNIFPERRTICIDSPSV--- 511
+ N ++A + + K ++ + I+V D+ND P T +
Sbjct: 450 TLLWHN----ITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQL 505
Query: 512 -----LISVNEHSYGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVLS---PGFYE 563
+ ++ G F+F + E ++ + + T+ ILT K + Y
Sbjct: 506 IQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYL 565
Query: 564 IPILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGV 623
+P+++ D+ V + C C D+H + S A +A +
Sbjct: 566 LPVVISDNDYPVQSSTGTVTVRVCAC-DHHGNMQSCHA------------------EALI 606
Query: 624 SNVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQPEGL 663
GL + ++L I++L L ++L +QR+ E L
Sbjct: 607 HPTGLSTGALVAILLCIVIL-LVTVVLFAALRRQRKKEPL 645
Score = 31.2 bits (69), Expect = 5.4
Identities = 17/57 (29%), Positives = 26/57 (45%), Gaps = 2/57 (3%)
Query: 811 DEDEGRPANDCLLIYDHEGVGSPVGSIGCCSWIVDDLDE--SCMETLDPKFRTLAEI 865
D D P D L Y +EG GS S+ + D D+ + P+F+ LA++
Sbjct: 724 DTDPTAPPYDSLATYAYEGTGSVADSLSSLESVTTDADQDYDYLSDWGPRFKKLADM 780
>gi|16306487 cadherin 7, type 2 preproprotein [Homo sapiens]
Length = 785
Score = 194 bits (494), Expect = 3e-49
Identities = 177/637 (27%), Positives = 284/637 (44%), Gaps = 61/637 (9%)
Query: 46 RQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQ-KITYRISGVGIDRPPYGVFTINP 104
R KR W+ E S + K+ SD + I Y +SG G +F I+
Sbjct: 44 RTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGAS----SIFIIDE 99
Query: 105 RTGEINITSVVDREITPLFLIYCRALNS-RGEDLERPLELRVKVMDINDNAPVFSQSVYT 163
TG+I+ T +DRE + + +AL+ + +E E +K+ DINDN P F YT
Sbjct: 100 NTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYT 159
Query: 164 ASIEENSDANTLVVKLCATDADEENHLNS-KIAYKIVSQEPSGAPMFILNRYTGEVCTMS 222
A + E S T VV++ ATDAD+ + NS ++ Y I+ G P F + TG + T
Sbjct: 160 AGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSIL----QGQPYFSVEPKTGVIKTAL 215
Query: 223 SFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENC 282
+DRE Y LV++ D G GLS + + DVNDN P + SY ++ E+
Sbjct: 216 PNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESL 275
Query: 283 -LSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQ 341
++S + R++A D D N +Y I+ G+ F I D +T EGI+ + K LD+E
Sbjct: 276 PVASVVARIKAADADIGA--NAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEA 333
Query: 342 APNIQLSIGVKNQ-ADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKG 400
+ L I N+ AD + F T V+I V DV E P F V E
Sbjct: 334 KTSYTLRIEAANKDADPRFLSLGPFS-DTTTVKIIVEDVDEPPVFSSPLYPMEVSE---- 388
Query: 401 SSLLNYVLGTYTAIDLDTGNPATDVRYIIGH--DAGSWLKIDSRTGEIQFSREFDKKSKY 458
++ + ++GT A D D+ N + VRY I D + ID+ +G I ++ D+++
Sbjct: 389 ATQVGNIIGTVAAHDPDSSN--SPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRET-- 444
Query: 459 IINGIYTAEILAID-DGSGKTATGTICIEVPDINDYCPNIFPE-RRTICIDS-PSVLI-- 513
N I+ +LA++ + G + I + DIND P + T+C ++ P +I
Sbjct: 445 --NAIHNITVLAMESQNPSQVGRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQK 502
Query: 514 ----SVNEHSYGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVL---SPGFYEIPI 566
+E S G F F + + + + + T++ILT + Y +PI
Sbjct: 503 ISAVDKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPI 562
Query: 567 LVKDSYNRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVSNV 626
+ DS + + + + CDCD D +A V
Sbjct: 563 FIVDSGSPSLSSTNTLTIRVCDCD-------------------ADGVAQTCNAEAYVLPA 603
Query: 627 GLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQPEGL 663
GL + ++ +L L++ L+LL+ ++R+ E L
Sbjct: 604 GLSTGALIAILACVLTLLV--LILLIVTMRRRKKEPL 638
>gi|16306489 cadherin 7, type 2 preproprotein [Homo sapiens]
Length = 785
Score = 194 bits (494), Expect = 3e-49
Identities = 177/637 (27%), Positives = 284/637 (44%), Gaps = 61/637 (9%)
Query: 46 RQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQ-KITYRISGVGIDRPPYGVFTINP 104
R KR W+ E S + K+ SD + I Y +SG G +F I+
Sbjct: 44 RTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGAS----SIFIIDE 99
Query: 105 RTGEINITSVVDREITPLFLIYCRALNS-RGEDLERPLELRVKVMDINDNAPVFSQSVYT 163
TG+I+ T +DRE + + +AL+ + +E E +K+ DINDN P F YT
Sbjct: 100 NTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYT 159
Query: 164 ASIEENSDANTLVVKLCATDADEENHLNS-KIAYKIVSQEPSGAPMFILNRYTGEVCTMS 222
A + E S T VV++ ATDAD+ + NS ++ Y I+ G P F + TG + T
Sbjct: 160 AGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSIL----QGQPYFSVEPKTGVIKTAL 215
Query: 223 SFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENC 282
+DRE Y LV++ D G GLS + + DVNDN P + SY ++ E+
Sbjct: 216 PNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESL 275
Query: 283 -LSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQ 341
++S + R++A D D N +Y I+ G+ F I D +T EGI+ + K LD+E
Sbjct: 276 PVASVVARIKAADADIGA--NAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEA 333
Query: 342 APNIQLSIGVKNQ-ADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKG 400
+ L I N+ AD + F T V+I V DV E P F V E
Sbjct: 334 KTSYTLRIEAANKDADPRFLSLGPFS-DTTTVKIIVEDVDEPPVFSSPLYPMEVSE---- 388
Query: 401 SSLLNYVLGTYTAIDLDTGNPATDVRYIIGH--DAGSWLKIDSRTGEIQFSREFDKKSKY 458
++ + ++GT A D D+ N + VRY I D + ID+ +G I ++ D+++
Sbjct: 389 ATQVGNIIGTVAAHDPDSSN--SPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRET-- 444
Query: 459 IINGIYTAEILAID-DGSGKTATGTICIEVPDINDYCPNIFPE-RRTICIDS-PSVLI-- 513
N I+ +LA++ + G + I + DIND P + T+C ++ P +I
Sbjct: 445 --NAIHNITVLAMESQNPSQVGRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQK 502
Query: 514 ----SVNEHSYGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVL---SPGFYEIPI 566
+E S G F F + + + + + T++ILT + Y +PI
Sbjct: 503 ISAVDKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPI 562
Query: 567 LVKDSYNRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVSNV 626
+ DS + + + + CDCD D +A V
Sbjct: 563 FIVDSGSPSLSSTNTLTIRVCDCD-------------------ADGVAQTCNAEAYVLPA 603
Query: 627 GLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQPEGL 663
GL + ++ +L L++ L+LL+ ++R+ E L
Sbjct: 604 GLSTGALIAILACVLTLLV--LILLIVTMRRRKKEPL 638
>gi|16445393 cadherin 12, type 2 preproprotein [Homo sapiens]
Length = 794
Score = 194 bits (493), Expect = 4e-49
Identities = 180/641 (28%), Positives = 289/641 (45%), Gaps = 62/641 (9%)
Query: 45 RRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQ-KITYRISGVGIDRPPYGVFTIN 103
+R KR W+ E S+ + K+ SD + + + Y +SG G VFTI+
Sbjct: 50 QRVKRGWVWNQFFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGT----VFTID 105
Query: 104 PRTGEINITSVVDREITPLFLIYCRALN-SRGEDLERPLELRVKVMDINDNAPVFSQSVY 162
TG+I+ +DRE P + + +A++ + LE E +KV DINDN P F Y
Sbjct: 106 ETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPY 165
Query: 163 TASIEENSDANTLVVKLCATDADEENHLNS-KIAYKIVSQEPSGAPMFILNRYTGEVCTM 221
A++ E S V+++ ATDAD+ + NS ++ Y I+ G P F ++ TG + T
Sbjct: 166 VATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSIL----QGQPYFSIDPKTGVIRTA 221
Query: 222 SSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEEN 281
+DRE Y ++++ D G GL+ I + DVNDN P K+ + + E+
Sbjct: 222 LPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPES 281
Query: 282 C-LSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYE 340
+ S + R++A+D D N +Y I+ G+ GN FDI TD T EG++K+ K LD+E
Sbjct: 282 SPIGSAIGRIRAVDPD--FGQNAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFE 339
Query: 341 QAPNIQLSIGVKN-QADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIK 399
+ N D + A F+ T V+I V+DV E P F V E
Sbjct: 340 TKKAYTFKVEASNLHLDHRFHSAGPFKDTAT-VKISVLDVDEPPVFSKPLYTMEVYE--- 395
Query: 400 GSSLLNYVLGTYTAIDLDTGNPATDVRYIIG--HDAGSWLKIDSRTGEIQFSREFDKKSK 457
+ + ++G TA DLD G+ A VRY I D S+ ID G I + D++S
Sbjct: 396 -DTPVGTIIGAVTAQDLDVGSSA--VRYFIDWKSDGDSYFTIDGNEGTIATNELLDRES- 451
Query: 458 YIINGIYTAEILAIDDGSG-KTATGTICIEVPDINDYCPNI-FPERRTICIDS-PSVLIS 514
Y I+A + T+ I I V D+N++ P I P +C ++ P +I
Sbjct: 452 ---TAQYNFSIIASKVSNPLLTSKVNILINVLDVNEFPPEISVPYETAVCENAKPGQIIQ 508
Query: 515 V------NEHSYGSPFTFCVVDEPPGIADMWDVRS-TNATSAILTAKQVLS---PGFYEI 564
+ + G F+F + E I + VR N T+ I T + S Y +
Sbjct: 509 IVSAADRDLSPAGQQFSFRLSPE-AAIKPNFTVRDFRNNTAGIETRRNGYSRRQQELYFL 567
Query: 565 PILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVS 624
P++++DS + + C CD + L I+
Sbjct: 568 PVVIEDSSYPVQSSTNTMTIRVCRCDSDGTILSCNVEAIFLP------------------ 609
Query: 625 NVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQPEGLGT 665
VGL G + +L ++++LA ++L + +Q++ + L T
Sbjct: 610 -VGLS-TGALIAILLCIVILLAIVVLYVALRRQKKKDTLMT 648
>gi|4826671 cadherin 18, type 2 preproprotein [Homo sapiens]
Length = 790
Score = 189 bits (479), Expect = 2e-47
Identities = 170/633 (26%), Positives = 289/633 (45%), Gaps = 57/633 (9%)
Query: 46 RQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQ-KITYRISGVGIDRPPYGVFTINP 104
R KR W+ E + K+ S+ + + Y ++G G +F I+
Sbjct: 50 RPKRGWVWNQFFVLEEHMGPDPQYVGKLHSNSDKGDGSVKYILTGEGAGT----IFIIDD 105
Query: 105 RTGEINITSVVDREITPLFLIYCRALNSR-GEDLERPLELRVKVMDINDNAPVFSQSVYT 163
TG+I+ T +DRE ++++ +A++ R + LE E +KV DINDNAP F+ Y
Sbjct: 106 TTGDIHSTKSLDREQKTHYVLHAQAIDRRTNKPLEPESEFIIKVQDINDNAPKFTDGPYI 165
Query: 164 ASIEENSDANTLVVKLCATDADEENHLNS-KIAYKIVSQEPSGAPMFILNRYTGEVCTMS 222
++ E SD T V+++ ATDAD+ + NS ++ Y I+ G P F ++ TG + T
Sbjct: 166 VTVPEMSDMGTSVLQVTATDADDPTYGNSARVVYSIL----QGQPYFSVDPKTGVIRTAL 221
Query: 223 SFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENC 282
+DRE Y++V++ D G GLS I + DVNDN P + Y + E+
Sbjct: 222 HNMDREAREHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDNPPRFPQKHYQLYVPESA 281
Query: 283 -LSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQ 341
+ S + +++A D D N Y I++G+ F I TD +T EGIL + K L+YE+
Sbjct: 282 QVGSAVGKIKANDADT--GSNADMTYSIINGDGMGIFSISTDKETREGILSLKKPLNYEK 339
Query: 342 APNIQLSI-GVKNQADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKG 400
+ L+I G DF +S F+ T ++I V DV E P F + V E K
Sbjct: 340 KKSYTLNIEGANTHLDFRFSHLGPFK-DATMLKIIVGDVDEPPLFSMPSYLMEVYENAK- 397
Query: 401 SSLLNYVLGTYTAIDLDTGNPATDVRYIIGHDA--GSWLKIDSRTGEIQFSREFDKKSKY 458
+ V+GT A D D+ N VRY I ++ + ID+ TG I+ ++ D++
Sbjct: 398 ---IGTVVGTVLAQDPDSTNSL--VRYFINYNVEDDRFFNIDANTGTIRTTKVLDREETP 452
Query: 459 IINGIYTAEILAIDDGSGKTATGTICIEVPDINDYCPNIFPERRTICIDS--PSVLISV- 515
N TA + D + T+ I V D+ND P + E I ++ P +I
Sbjct: 453 WYNITVTASEI---DNPDLLSHVTVGIRVLDVNDNPPELAREYDIIVCENSKPGQVIHTI 509
Query: 516 -----NEHSYGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVLS---PGFYEIPIL 567
++ + G F F + + P + + + T++ILT ++ S Y +PI+
Sbjct: 510 SATDKDDFANGPRFNFFLDERLPVNPNFTLKDNEDNTASILTRRRRFSRTVQDVYYLPIM 569
Query: 568 VKDSYNRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVSNVG 627
+ D + + + + C C+ + A +A +S+ G
Sbjct: 570 ISDGGIPSLSSSSTLTIRVCACERDGRVRTCHA-------------------EAFLSSAG 610
Query: 628 LGPAGIGMMVLGILLLILAPLLLLLCCCKQRQP 660
L + ++L +L+L+ +L + +++P
Sbjct: 611 LSTGALIAILLCVLILLAIVVLFITLRRSKKEP 643
Score = 31.2 bits (69), Expect = 5.4
Identities = 24/73 (32%), Positives = 32/73 (43%), Gaps = 2/73 (2%)
Query: 802 FSEKAYAYADEDEGRPANDCLLIYDHEGVGSPVGSIGC--CSWIVDDLDESCMETLDPKF 859
F ++ A AD D P D L Y +EG S GSI + D D + P+F
Sbjct: 715 FIKQRLAEADLDPSVPPYDSLQTYAYEGQRSEAGSISSLDSATTQSDQDYHYLGDWGPEF 774
Query: 860 RTLAEICLNTEIE 872
+ LAE+ E E
Sbjct: 775 KKLAELYGEIESE 787
>gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens]
Length = 801
Score = 184 bits (466), Expect = 5e-46
Identities = 159/573 (27%), Positives = 257/573 (44%), Gaps = 42/573 (7%)
Query: 40 KWQTVRRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQ-KITYRISGVGIDRPPYG 98
K Q+ +R KR W+ E + + K+ SD + I Y +SG G
Sbjct: 50 KPQSHQRTKRSWVWNQFFVLEEYTGTDPLYVGKLHSDMDRGDGSIKYILSGEGAGI---- 105
Query: 99 VFTINPRTGEINITSVVDREITPLFLIYCRALNSR-GEDLERPLELRVKVMDINDNAPVF 157
VFTI+ TG+I+ +DRE + + +AL+ R G +E E +K+ DINDN P F
Sbjct: 106 VFTIDDTTGDIHAIQRLDREERAQYTLRAQALDRRTGRPMEPESEFIIKIQDINDNEPKF 165
Query: 158 SQSVYTASIEENSDANTLVVKLCATDADEENHLNS-KIAYKIVSQEPSGAPMFILNRYTG 216
Y A++ E S T V+++ ATDAD+ + NS ++ Y I+ G P F ++ TG
Sbjct: 166 LDGPYVATVPEMSPVGTSVIQVTATDADDPTYGNSARVVYSIL----QGQPYFSVDSKTG 221
Query: 217 EVCTMSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSA 276
+ T +DRE Y ++++ D G GL+ I + DVNDN P + Y
Sbjct: 222 VIRTALMNMDREAKEYYEVIIQAKDMGGQLGGLAGTTTVNITLSDVNDNPPRFPQKHYQM 281
Query: 277 SIEENC-LSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVK 335
S+ E+ +SS + R+ A DLDE N +Y I+ G+ + FDI TDP GI+ V K
Sbjct: 282 SVLESAPISSTVGRVFAKDLDE--GINAEMKYTIVDGDGADAFDISTDPNFQVGIITVKK 339
Query: 336 MLDYEQAPNIQLSI-GVKNQADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSV 394
L +E + L + G + + FQ T V I V DV E P F P V
Sbjct: 340 PLSFESKKSYTLKVEGANPHLEMRFLNLGPFQ-DTTTVHISVEDVDEPPVFEPGFYFVEV 398
Query: 395 REGIKGSSLLNYVLGTYTAIDLDTGNPATDVRYII--GHDAGSWLKIDSRTGEIQFSREF 452
E + + + + +A D D N +RY I D G + +D TG + +R
Sbjct: 399 PEDVAIGTTIQII----SAKDPDVTN--NSIRYSIDRSSDPGRFFYVDITTGALMTARPL 452
Query: 453 DKKSKYIINGIYTAEILAID-DGSGKTATGTICIEVPDINDYCPNIFPE--RRTICIDSP 509
D++ + +LA++ + + + + I+V D+ND P FP +C ++
Sbjct: 453 DREE----FSWHNITVLAMEMNNPSQVGSVPVTIKVLDVNDNAPE-FPRFYEAFVCENAK 507
Query: 510 S-------VLISVNEHSYGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAK---QVLSP 559
+ + ++ G F + + E + + + T+ ILT + +
Sbjct: 508 AGQLIQTVSAVDQDDPRNGQHFYYSLAPEAANNPNFTIRDNQDNTARILTRRSGFRQQEQ 567
Query: 560 GFYEIPILVKDSYNRACELAQMVQLYACDCDDN 592
+ +PIL+ DS + + C CDD+
Sbjct: 568 SVFHLPILIADSGQPVLSSTGTLTIQVCSCDDD 600
>gi|16306532 cadherin 11, type 2 preproprotein [Homo sapiens]
Length = 796
Score = 176 bits (445), Expect = 1e-43
Identities = 173/645 (26%), Positives = 281/645 (43%), Gaps = 69/645 (10%)
Query: 42 QTVRRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQ-KITYRISGVGIDRPPYGVF 100
Q ++R KR W+ E + ++ SD +S I Y +SG G +F
Sbjct: 46 QVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKYILSGEGAGT----IF 101
Query: 101 TINPRTGEINITSVVDREITPLFLIYCRALN-SRGEDLERPLELRVKVMDINDNAPVFSQ 159
I+ ++G I+ T +DRE + + +A++ LE P E VKV DINDN P F
Sbjct: 102 VIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLH 161
Query: 160 SVYTASIEENSDANTLVVKLCATDADEENHLNS-KIAYKIVSQEPSGAPMFILNRYTGEV 218
Y A++ E S+ T V+++ A+DAD+ + NS K+ Y I+ G P F + TG +
Sbjct: 162 ETYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSIL----EGQPYFSVEAQTGII 217
Query: 219 CTMSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASI 278
T +DRE Y++V++ D G GLS I + DVNDN P ++ Y S+
Sbjct: 218 RTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQSVYQMSV 277
Query: 279 EENCLSSELI-RLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKML 337
E + E + R++A D D +N L Y I+ G+ F+I TD +T EG++K+ K +
Sbjct: 278 SEAAVPGEEVGRVKAKDPDI--GENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPV 335
Query: 338 DYEQAPNIQLSIGVKN-QADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVRE 396
D+E L + N D + F+ T V+I V D E P F + V+E
Sbjct: 336 DFETKRAYSLKVEAANVHIDPKFISNGPFKDTVT-VKISVEDADEPPMFLAPSYIHEVQE 394
Query: 397 GIKGSSLLNYVLGTYTAIDLDTGNPATDVRYIIGH--DAGSWLKIDSRTGEIQFSREFDK 454
+ V+G A D D N + +RY I D + I+ G I+ ++ D+
Sbjct: 395 NAAAGT----VVGRVHAKDPDAAN--SPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDR 448
Query: 455 KSKYIIN-GIYTAEILAIDDGSGKTATGTICIEVPDINDYCPNI-FPERRTIC------- 505
+ +N ++ AEI + A + I V D+ND P P IC
Sbjct: 449 EETAWLNITVFAAEI----HNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKP 504
Query: 506 -IDSPSVLISVNEH---SYGSPFTFCVVDEPPGIA--DMWDVRSTNATSAILTAKQ---- 555
+ P V IS ++ + G F F + PP I + VR +A + A++
Sbjct: 505 LSNQPIVTISADDKDDTANGPRFIFSL---PPEIIHNPNFTVRDNRDNTAGVYARRGGFS 561
Query: 556 VLSPGFYEIPILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGP 615
Y +PI++ D + + C CD N L A
Sbjct: 562 RQKQDLYLLPIVISDGGIPPMSSTNTLTIKVCGCDVNGALLSCNA--------------- 606
Query: 616 VTEDQAGVSNVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQP 660
+A + N GL + ++ I++L++ +L + ++++P
Sbjct: 607 ----EAYILNAGLSTGALIAILACIVILLVIVVLFVTLRRQKKEP 647
Score = 36.6 bits (83), Expect = 0.13
Identities = 20/58 (34%), Positives = 29/58 (50%), Gaps = 2/58 (3%)
Query: 810 ADEDEGRPANDCLLIYDHEGVGSPVGSIGCCSWIV--DDLDESCMETLDPKFRTLAEI 865
AD D P D + IY +EG GS GS+ DLD ++ P+F+ LA++
Sbjct: 728 ADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESATTDSDLDYDYLQNWGPRFKKLADL 785
>gi|221316595 cadherin 17 precursor [Homo sapiens]
Length = 832
Score = 176 bits (445), Expect = 1e-43
Identities = 155/574 (27%), Positives = 247/574 (43%), Gaps = 65/574 (11%)
Query: 93 DRPPYGVFTINPRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDIND 152
++ P F+I+ + G+I +T +DRE ++ Y A + G+ L PLE+ VKV DIND
Sbjct: 277 EKLPRFPFSID-QEGDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDIND 335
Query: 153 NAPVFSQSVYTASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEPSGAPM---F 209
N P V ++EN + L A D DEEN NS + Y+IV Q P PM F
Sbjct: 336 NPPTCPSPVTVFEVQENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPK-LPMDGLF 394
Query: 210 ILNRYTGEVCTMSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTL 269
++ Y G + L ++ YNL + SD+D + C +I V+D+ND P
Sbjct: 395 LIQTYAGMLQLAKQSLKKQDTPQYNLTIEVSDKD-----FKTLCFVQINVIDINDQIPIF 449
Query: 270 EKTSYS--ASIEENCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTN 327
EK+ Y E+ + S ++ +QA D DE T + Y I+ G+ + TDP TN
Sbjct: 450 EKSDYGNLTLAEDTNIGSTILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTN 509
Query: 328 EGILKVVKMLDYEQAPNIQLSIGVKNQADFHYSV---ASQFQMHPTPVRIQVVDVREGPA 384
G + + K LD+E A + +N + V AS F + V DV E P
Sbjct: 510 TGYVIIKKPLDFETAAVSNIVFKAENPEPLVFGVKYNASSF----AKFTLIVTDVNEAPQ 565
Query: 385 FHPSTMAFSVREGIKGSSLLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKIDSRTG 444
F V E + + +G TA D + D+ Y + D WLKID TG
Sbjct: 566 FSQHVFQAKVSEDV----AIGTKVGNVTAKDPE----GLDISYSLRGDTRGWLKIDHVTG 617
Query: 445 EIQFSREFDKKSKYIINGIYTAEILAID-DGSGKTATGTICIEVPDINDYCPNIFPERRT 503
EI D+++ Y +++A + GS ++ + + D+ND P + +
Sbjct: 618 EIFSVAPLDREA----GSPYRVQVVATEVGGSSLSSVSEFHLILMDVNDNPPRLAKDYTG 673
Query: 504 IC----IDSPSVLI----SVNEHSYGSP-FTFCVVDEPPGIADMWDVRSTNATSAILTAK 554
+ + +P LI ++H + P FTF + + + W+V N T A L+ +
Sbjct: 674 LFFCHPLSAPGSLIFEATDDDQHLFRGPHFTFSL--GSGSLQNDWEVSKINGTHARLSTR 731
Query: 555 QV-LSPGFYEIPILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTY 613
Y + I + D E + + C C + G +
Sbjct: 732 HTEFEEREYVVLIRINDGGRPPLEGIVSLPVTFCSC------------------VEGSCF 773
Query: 614 GPVTEDQAGVSNVGL--GPAGIGMMVLGILLLIL 645
P Q G+ VG+ G ++V+GI+L ++
Sbjct: 774 RPAGH-QTGIPTVGMAVGILLTTLLVIGIILAVV 806
Score = 90.5 bits (223), Expect = 8e-18
Identities = 118/450 (26%), Positives = 189/450 (42%), Gaps = 59/450 (13%)
Query: 99 VFTINPRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFS 158
+F I R G + +DRE + AL++ G +E P+ + +KV DINDN P F
Sbjct: 69 IFVIE-REGLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNRPTFL 127
Query: 159 QSVYTASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEP--SGAPMFILNRYTG 216
QS Y S+ +NS + + ATD D+ N ++ Y+IV Q P + F +N TG
Sbjct: 128 QSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQINNKTG 187
Query: 217 EVCTM---SSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTS 273
+ S L+ ++ YNLV+ D G ++ +S D + V +N + K
Sbjct: 188 AISLTREGSQELNPAKNPSYNLVISVKDMGGQSE--NSFSDTTSVDIIVTEN---IWKAP 242
Query: 274 YSASIEENCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKV 333
+ EN I++ + ++ G AQY ++ F D EG + V
Sbjct: 243 KPVEMVENSTDPHPIKITQVRWNDPG-----AQYSLVDKEKLPRFPFSID---QEGDIYV 294
Query: 334 VKMLDYEQAPNIQLSIGVKNQADFHYSVASQFQ----MHPTPVRIQVVDVREGPAFHPST 389
+ LD E+ A Y+VA +P + ++V D+ + P PS
Sbjct: 295 TQPLDREE-----------KDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSP 343
Query: 390 M-AFSVREGIKGSSLLNYVLGTYTAIDLDTGNPATD-VRYIIGHDA------GSWLKIDS 441
+ F V+E + L +GT TA D D N A + Y I G +L I +
Sbjct: 344 VTVFEVQE----NERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFL-IQT 398
Query: 442 RTGEIQFSREFDKKSKYIINGIYTAEILAIDDGSGKTATGTICIEVPDINDYCPNIFPE- 500
G +Q +++ KK + + + D KT + I V DIND P IF +
Sbjct: 399 YAGMLQLAKQSLKKQDTPQYNL----TIEVSDKDFKTLC-FVQINVIDINDQIP-IFEKS 452
Query: 501 ---RRTICIDS--PSVLISVNEHSYGSPFT 525
T+ D+ S ++++ PFT
Sbjct: 453 DYGNLTLAEDTNIGSTILTIQATDADEPFT 482
>gi|221316593 cadherin 17 precursor [Homo sapiens]
Length = 832
Score = 176 bits (445), Expect = 1e-43
Identities = 155/574 (27%), Positives = 247/574 (43%), Gaps = 65/574 (11%)
Query: 93 DRPPYGVFTINPRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDIND 152
++ P F+I+ + G+I +T +DRE ++ Y A + G+ L PLE+ VKV DIND
Sbjct: 277 EKLPRFPFSID-QEGDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDIND 335
Query: 153 NAPVFSQSVYTASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEPSGAPM---F 209
N P V ++EN + L A D DEEN NS + Y+IV Q P PM F
Sbjct: 336 NPPTCPSPVTVFEVQENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPK-LPMDGLF 394
Query: 210 ILNRYTGEVCTMSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTL 269
++ Y G + L ++ YNL + SD+D + C +I V+D+ND P
Sbjct: 395 LIQTYAGMLQLAKQSLKKQDTPQYNLTIEVSDKD-----FKTLCFVQINVIDINDQIPIF 449
Query: 270 EKTSYS--ASIEENCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTN 327
EK+ Y E+ + S ++ +QA D DE T + Y I+ G+ + TDP TN
Sbjct: 450 EKSDYGNLTLAEDTNIGSTILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTN 509
Query: 328 EGILKVVKMLDYEQAPNIQLSIGVKNQADFHYSV---ASQFQMHPTPVRIQVVDVREGPA 384
G + + K LD+E A + +N + V AS F + V DV E P
Sbjct: 510 TGYVIIKKPLDFETAAVSNIVFKAENPEPLVFGVKYNASSF----AKFTLIVTDVNEAPQ 565
Query: 385 FHPSTMAFSVREGIKGSSLLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKIDSRTG 444
F V E + + +G TA D + D+ Y + D WLKID TG
Sbjct: 566 FSQHVFQAKVSEDV----AIGTKVGNVTAKDPE----GLDISYSLRGDTRGWLKIDHVTG 617
Query: 445 EIQFSREFDKKSKYIINGIYTAEILAID-DGSGKTATGTICIEVPDINDYCPNIFPERRT 503
EI D+++ Y +++A + GS ++ + + D+ND P + +
Sbjct: 618 EIFSVAPLDREA----GSPYRVQVVATEVGGSSLSSVSEFHLILMDVNDNPPRLAKDYTG 673
Query: 504 IC----IDSPSVLI----SVNEHSYGSP-FTFCVVDEPPGIADMWDVRSTNATSAILTAK 554
+ + +P LI ++H + P FTF + + + W+V N T A L+ +
Sbjct: 674 LFFCHPLSAPGSLIFEATDDDQHLFRGPHFTFSL--GSGSLQNDWEVSKINGTHARLSTR 731
Query: 555 QV-LSPGFYEIPILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTY 613
Y + I + D E + + C C + G +
Sbjct: 732 HTEFEEREYVVLIRINDGGRPPLEGIVSLPVTFCSC------------------VEGSCF 773
Query: 614 GPVTEDQAGVSNVGL--GPAGIGMMVLGILLLIL 645
P Q G+ VG+ G ++V+GI+L ++
Sbjct: 774 RPAGH-QTGIPTVGMAVGILLTTLLVIGIILAVV 806
Score = 90.5 bits (223), Expect = 8e-18
Identities = 118/450 (26%), Positives = 189/450 (42%), Gaps = 59/450 (13%)
Query: 99 VFTINPRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFS 158
+F I R G + +DRE + AL++ G +E P+ + +KV DINDN P F
Sbjct: 69 IFVIE-REGLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNRPTFL 127
Query: 159 QSVYTASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEP--SGAPMFILNRYTG 216
QS Y S+ +NS + + ATD D+ N ++ Y+IV Q P + F +N TG
Sbjct: 128 QSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQINNKTG 187
Query: 217 EVCTM---SSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTS 273
+ S L+ ++ YNLV+ D G ++ +S D + V +N + K
Sbjct: 188 AISLTREGSQELNPAKNPSYNLVISVKDMGGQSE--NSFSDTTSVDIIVTEN---IWKAP 242
Query: 274 YSASIEENCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKV 333
+ EN I++ + ++ G AQY ++ F D EG + V
Sbjct: 243 KPVEMVENSTDPHPIKITQVRWNDPG-----AQYSLVDKEKLPRFPFSID---QEGDIYV 294
Query: 334 VKMLDYEQAPNIQLSIGVKNQADFHYSVASQFQ----MHPTPVRIQVVDVREGPAFHPST 389
+ LD E+ A Y+VA +P + ++V D+ + P PS
Sbjct: 295 TQPLDREE-----------KDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSP 343
Query: 390 M-AFSVREGIKGSSLLNYVLGTYTAIDLDTGNPATD-VRYIIGHDA------GSWLKIDS 441
+ F V+E + L +GT TA D D N A + Y I G +L I +
Sbjct: 344 VTVFEVQE----NERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFL-IQT 398
Query: 442 RTGEIQFSREFDKKSKYIINGIYTAEILAIDDGSGKTATGTICIEVPDINDYCPNIFPE- 500
G +Q +++ KK + + + D KT + I V DIND P IF +
Sbjct: 399 YAGMLQLAKQSLKKQDTPQYNL----TIEVSDKDFKTLC-FVQINVIDINDQIP-IFEKS 452
Query: 501 ---RRTICIDS--PSVLISVNEHSYGSPFT 525
T+ D+ S ++++ PFT
Sbjct: 453 DYGNLTLAEDTNIGSTILTIQATDADEPFT 482
>gi|90193626 cadherin 9, type 2 preproprotein [Homo sapiens]
Length = 789
Score = 174 bits (441), Expect = 4e-43
Identities = 170/638 (26%), Positives = 284/638 (44%), Gaps = 58/638 (9%)
Query: 44 VRRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQ-KITYRISGVGIDRPPYGVFTI 102
+RR KR W+ E + + K+ +D + + Y ++G G +F I
Sbjct: 48 LRRTKRGWMWNQFFLLEEYTGTDTQYVGKLHTDQDKGDGNLKYILTGDGAG----SLFVI 103
Query: 103 NPRTGEINITSVVDREITPLFLIYCRALNSR-GEDLERPLELRVKVMDINDNAPVFSQSV 161
+ TG+I+ +DRE L+++ +A++ + G +E E +K+ DINDN P F++ +
Sbjct: 104 DENTGDIHAAKKLDREEKSLYILRAKAIDRKTGRQVEPESEFIIKIHDINDNEPKFTKDL 163
Query: 162 YTASIEENSDANTLVVKLCATDADEENHLNS-KIAYKIVSQEPSGAPMFILNRYTGEVCT 220
YTAS+ E S T V+++ ATDAD+ N+ NS K+ Y I+ G P F ++ +G + T
Sbjct: 164 YTASVPEMSGVGTSVIQVTATDADDANYGNSAKVVYSIL----QGQPYFSVDPESGIIKT 219
Query: 221 MSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEE 280
+ RE Y +V++ D G GLS I + DVN+N P +++Y + E
Sbjct: 220 ALPDMSRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNNNPPRFPQSTYQFNSPE 279
Query: 281 NC-LSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDY 339
+ L + L R++A D D +N +Y I G+ + FD+ TD T EGI+ V + LD+
Sbjct: 280 SVPLGTHLGRIKANDPDV--GENAEMEYSIAEGDGADMFDVITDKDTQEGIITVKQNLDF 337
Query: 340 EQAPNIQLSIGVKN-QADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGI 398
E L + N D + F+ V+I V D+ E P F + V E +
Sbjct: 338 ENQMLYTLRVDASNTHPDPRFLHLGPFK-DTAVVKISVEDIDEPPVFTKVSYLIEVDEDV 396
Query: 399 KGSSLLNYVLGTYTAIDLDTGNPATDVRYIIGH--DAGSWLKIDSRTGEIQFSREFDKKS 456
K S ++G TA D D N ++Y + D I S G I + D++S
Sbjct: 397 KEGS----IIGQVTAYDPDARNNL--IKYSVDRHTDMDRIFGIHSENGSIFTLKALDRES 450
Query: 457 KYIINGIYTAEILAIDDGSGKTATGTICIEVPDINDYCPNIFPERRTICIDS--PSVLIS 514
N TA + + +++ + I + DIND+ P T ++ P LI
Sbjct: 451 SPWHNITVTATEI---NNPKQSSHIPVFIRILDINDHAPEFAMYYETFVCENAKPGQLIQ 507
Query: 515 V------NEHSYGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVLS---PGFYEIP 565
++ G F F V E + V + + T+ I+T K S Y +P
Sbjct: 508 TVSVMDKDDPPRGHKFFFEPVPEFTLNPNFTIVDNKDNTAGIMTRKDGYSRNKMSTYLLP 567
Query: 566 ILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVSN 625
IL+ D+ + + C C DN + S A +A + +
Sbjct: 568 ILIFDNDYPIQSSTGTLTIRVCAC-DNQGNMQSCTA------------------EALILS 608
Query: 626 VGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQPEGL 663
GL + ++L +L+L++ ++L +QR+ E L
Sbjct: 609 AGLSTGALVAILLCVLILLIL-VVLFAALKRQRKKEPL 645
>gi|16306530 cadherin 10, type 2 preproprotein [Homo sapiens]
Length = 788
Score = 174 bits (440), Expect = 5e-43
Identities = 168/636 (26%), Positives = 280/636 (44%), Gaps = 61/636 (9%)
Query: 44 VRRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQ-KITYRISGVGIDRPPYGVFTI 102
+ RQKR W+ E S + K+ SD + + Y +SG G +F I
Sbjct: 49 LHRQKRGWMWNQFFLLEEYTGSDYQYVGKLHSDQDKGDGSLKYILSGDGAGT----LFII 104
Query: 103 NPRTGEINITSVVDREITPLFLIYCRALNSRG-EDLERPLELRVKVMDINDNAPVFSQSV 161
+ +TG+I+ T +DRE + + +A+N R +E E +K+ DINDN P F + +
Sbjct: 105 DEKTGDIHATRRIDREEKAFYTLRAQAINRRTLRPVEPESEFVIKIHDINDNEPTFPEEI 164
Query: 162 YTASIEENSDANTLVVKLCATDADEENHLNS-KIAYKIVSQEPSGAPMFILNRYTGEVCT 220
YTAS+ E S T VV++ ATDAD+ ++ NS ++ Y I+ G P F + TG + T
Sbjct: 165 YTASVPEMSVVGTSVVQVTATDADDPSYGNSARVIYSIL----QGQPYFSVEPETGIIRT 220
Query: 221 MSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTL-EKTSYSASIE 279
++RE Y +V++ D G GLS I + DVNDN P + T + +E
Sbjct: 221 ALPNMNRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQNTIHLRVLE 280
Query: 280 ENCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDY 339
+ + + + ++A D D N +Y I+ G+ + FDI T+ T EGI+ V K LDY
Sbjct: 281 SSPVGTAIGSVKATDADT--GKNAEVEYRIIDGDGTDMFDIVTEKDTQEGIITVKKPLDY 338
Query: 340 EQAPNIQLSIGVKN-QADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGI 398
E L + +N D + F+ T V+I + DV E P F S+ F V E I
Sbjct: 339 ESRRLYTLKVEAENTHVDPRFYYLGPFK-DTTIVKISIEDVDEPPVFSRSSYLFEVHEDI 397
Query: 399 KGSSLLNYVLGTYTAIDLDTGNPATDVRYIIGH--DAGSWLKIDSRTGEIQFSREFDKK- 455
+ + ++GT A D D + ++ +R+ + D I S G + S+ D++
Sbjct: 398 E----VGTIIGTVMARDPD--SISSPIRFSLDRHTDLDRIFNIHSGNGSLYTSKPLDREL 451
Query: 456 SKYIINGIYTAEILAIDDGSGKTATGTICIEVPDINDYCPNIFPERRTICIDS--PSVLI 513
S++ + AEI + +T + + + D+ND P T ++ P LI
Sbjct: 452 SQWHNLTVIAAEI----NNPKETTRVAVFVRILDVNDNAPQFAVFYDTFVCENARPGQLI 507
Query: 514 SV------NEHSYGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVLSP---GFYEI 564
++ G F F + P + + T+ ILT K + Y +
Sbjct: 508 QTISAVDKDDPLGGQKFFFSLAAVNPNFTVQ---DNEDNTARILTRKNGFNRHEISTYLL 564
Query: 565 PILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVS 624
P+++ D+ + + C CD A + AG+S
Sbjct: 565 PVVISDNDYPIQSSTGTLTIRVCACDSQGNMQSCSAEALLL--------------PAGLS 610
Query: 625 NVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQP 660
L I +++ I+LL++ L L ++++P
Sbjct: 611 TGAL----IAILLCIIILLVIVVLFAALKRQRKKEP 642
>gi|16753221 cadherin 22 precursor [Homo sapiens]
Length = 828
Score = 172 bits (435), Expect = 2e-42
Identities = 217/853 (25%), Positives = 334/853 (39%), Gaps = 129/853 (15%)
Query: 46 RQKREWIKFAAACREGEDNSKRNPIAKIRSDC-ESNQKITYRISGVGIDRPPYGVFTINP 104
R KR W+ E ++ + KI SD E + I Y ISG G +F I+
Sbjct: 59 RVKRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGAIKYTISGEGAGT----IFLIDE 114
Query: 105 RTGEINITSVVDREITPLFLIYCRALNSRGEDLERP-LELRVKVMDINDNAPVFSQSVYT 163
TG+I+ +DRE + + +A + L P E +KV DIND+ P F Y
Sbjct: 115 LTGDIHAMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYI 174
Query: 164 ASIEENSDANTLVVKLCATDADEENHLNS-KIAYKIVSQEPSGAPMFILNRYTGEVCTMS 222
S+ E S T V+++ A+DAD+ + +S ++ Y ++ G F ++ TG + T
Sbjct: 175 GSVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVLD----GEHHFTVDPKTGVIRTAV 230
Query: 223 SFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENC 282
LDRE Y +V++ +D G GLS I V DVNDN P + Y SI+E+
Sbjct: 231 PDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESA 290
Query: 283 -LSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQ 341
+ + + R++A D D + S + G+ F + TD T E I+ V K LD+E
Sbjct: 291 PIGTAVGRVKAEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFES 350
Query: 342 APNIQLSIGVKNQ-ADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKG 400
P + + N+ D ++ F+ VR+ V DV E P F P + V+E +
Sbjct: 351 QPVHTVILEALNKFVDPRFADLGTFR-DQAIVRVAVTDVDEPPEFRPPSGLLEVQEDAQV 409
Query: 401 SSLLNYVLGTYTAIDLDTGNPATDVRYIIGH--DAGSWLKIDSRTGEIQFSREFDKKSKY 458
SL +G TA D D N VRY I D ID+ TG I + D+++
Sbjct: 410 GSL----VGVVTARDPDAAN--RPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETA- 462
Query: 459 IINGIYTAEILAID-DGSGKTATGTICIEVPDINDYCPNI-FPERRTICIDS-PSVLISV 515
G + +LA++ D + + ++ I + D+ND P + P +C D+ P LI
Sbjct: 463 ---GWHNITVLAMEADNHAQLSRASLRIRILDVNDNPPELATPYEAAVCEDAKPGQLIQT 519
Query: 516 ------NEHSYGSPFTFCVVDEPP-----GIADMWDVRSTNATSAILTAKQVLSPGFYEI 564
+E G F F +V E P + D+ D + T + +Q + +
Sbjct: 520 ISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIQDNTAAVHTQHVGFNRQ--EQDVFFL 577
Query: 565 PILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVS 624
PILV DS + + C CD + A V
Sbjct: 578 PILVVDSGPPTLSSTGTLTIRICGCDSSGTIQSCNTT-------------------AFVM 618
Query: 625 NVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQPEGLGTRFAPVPEGGEGVMQSWRIE 684
L P ++ L + +LIL L+LL+ ++ L + E + + E
Sbjct: 619 AASLSPG--ALIALLVCVLILVVLVLLILTLRRHHKSHLS---SDEDEDMRDNVIKYNDE 673
Query: 685 GAHPED----------RLFSAYALPGGGGTADGGGSVLGRCALQATPALLNQHPPFSEIY 734
G +D L+ L GG DGGGS
Sbjct: 674 GGGEQDTEAYDMSALRSLYDFGELKGG----DGGGS------------------------ 705
Query: 735 TNTYAAGGTVEGGVSGVELNTGMGTAVGLMAAGAAGASGAARKRSSTMGTLRDYADADIN 794
AGG GG + G AG+ A S + + +
Sbjct: 706 -----AGGGAGGG-----------------SGGGAGSPPQAHLPSERHSLPQGPPSPEPD 743
Query: 795 MAFLDSYFSEKAYAYADEDEGRPANDCLLIYDHEGVGSPVGSIGC--CSWIVDDLDESCM 852
+ + S K A AD D P D Y EG SP S+ + D + +
Sbjct: 744 FSVFRDFISRKV-ALADGDLSVPPYDAFQTYAFEGADSPAASLSSLHSGSSGSEQDFAYL 802
Query: 853 ETLDPKFRTLAEI 865
+ P+FR LA +
Sbjct: 803 SSWGPRFRPLAAL 815
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,204,212
Number of Sequences: 37866
Number of extensions: 2059912
Number of successful extensions: 7807
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 193
Number of HSP's successfully gapped in prelim test: 28
Number of HSP's that attempted gapping in prelim test: 4874
Number of HSP's gapped (non-prelim): 950
length of query: 1059
length of database: 18,247,518
effective HSP length: 113
effective length of query: 946
effective length of database: 13,968,660
effective search space: 13214352360
effective search space used: 13214352360
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.