Search of human proteins with 194272224

Search of human proteins with 194272224

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|194272224 leucine rich repeat containing 48 isoform a [Homo
sapiens]
         (523 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|194272224 leucine rich repeat containing 48 isoform a [Homo s...  1035   0.0  
gi|194272222 leucine rich repeat containing 48 isoform a [Homo s...  1035   0.0  
gi|194272228 leucine rich repeat containing 48 isoform b [Homo s...   874   0.0  
gi|194272226 leucine rich repeat containing 48 isoform b [Homo s...   874   0.0  
gi|87298937 centrosomal protein 110kDa [Homo sapiens]                  97   3e-20
gi|4506013 protein phosphatase 1, regulatory subunit 7 [Homo sap...    92   9e-19
gi|21389483 leucine-rich repeats and guanylate kinase domain con...    86   1e-16
gi|157674358 leucine rich repeat containing 50 [Homo sapiens]          80   3e-15
gi|55743114 leucine rich repeat containing 49 [Homo sapiens]           79   8e-15
gi|117414162 sodium channel associated protein 2 isoform a [Homo...    72   9e-13
gi|66472382 nischarin [Homo sapiens]                                   71   3e-12
gi|31377705 centrosomal protein 97kDa [Homo sapiens]                   70   4e-12
gi|31621309 leucine rich repeat containing 6 [Homo sapiens]            69   8e-12
gi|239752518 PREDICTED: similar to leucine rich repeat containin...    67   3e-11
gi|206725447 leucine rich repeat containing 23 isoform a [Homo s...    67   3e-11
gi|42542396 leucine rich repeat containing 23 isoform a [Homo sa...    67   3e-11
gi|164607156 axonemal dynein light chain 1 [Homo sapiens]              64   3e-10
gi|5454088 acidic (leucine-rich) nuclear phosphoprotein 32 famil...    60   4e-09
gi|50593002 small nuclear ribonucleoprotein polypeptide A' [Homo...    58   2e-08
gi|16904383 leucine rich repeat containing 7 [Homo sapiens]            55   1e-07
gi|5453880 acidic (leucine-rich) nuclear phosphoprotein 32 famil...    55   2e-07
gi|15529980 leucine rich repeat containing 46 [Homo sapiens]           55   2e-07
gi|40255157 leucine-rich repeats and immunoglobulin-like domains...    54   3e-07
gi|120953300 leucine-rich repeats and IQ motif containing 1 isof...    54   3e-07
gi|120953243 leucine-rich repeats and IQ motif containing 1 isof...    54   3e-07
gi|209862903 leucine-rich repeats and immunoglobulin-like domain...    54   3e-07
gi|61966709 leucine rich repeat containing 67 [Homo sapiens]           54   5e-07
gi|62912472 leucine-rich repeat-containing G protein-coupled rec...    54   5e-07
gi|62912470 leucine-rich repeat-containing G protein-coupled rec...    54   5e-07
gi|239754500 PREDICTED: Leucine-rich repeat-containing protein E...    52   1e-06

>gi|194272224 leucine rich repeat containing 48 isoform a [Homo
           sapiens]
          Length = 523

 Score = 1035 bits (2677), Expect = 0.0
 Identities = 523/523 (100%), Positives = 523/523 (100%)

Query: 1   MNQPCNSMEPRVMDDDMLKLAVGDQGPQEEAGQLAKQEGILFKDVLSLQLDFRNILRIDN 60
           MNQPCNSMEPRVMDDDMLKLAVGDQGPQEEAGQLAKQEGILFKDVLSLQLDFRNILRIDN
Sbjct: 1   MNQPCNSMEPRVMDDDMLKLAVGDQGPQEEAGQLAKQEGILFKDVLSLQLDFRNILRIDN 60

Query: 61  LWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNR 120
           LWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNR
Sbjct: 61  LWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNR 120

Query: 121 ISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICA 180
           ISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICA
Sbjct: 121 ISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICA 180

Query: 181 YLPDLMYLDYRRIDDHTKKLAEAKHQYSIDELKHQENLMQAQLEDEQAQREELEKHKTAF 240
           YLPDLMYLDYRRIDDHTKKLAEAKHQYSIDELKHQENLMQAQLEDEQAQREELEKHKTAF
Sbjct: 181 YLPDLMYLDYRRIDDHTKKLAEAKHQYSIDELKHQENLMQAQLEDEQAQREELEKHKTAF 240

Query: 241 VEHLNGSFLFDSMYAEDSEGNNLSYLPGVGELLETYKDKFVIICVNIFEYGLKQQEKRKT 300
           VEHLNGSFLFDSMYAEDSEGNNLSYLPGVGELLETYKDKFVIICVNIFEYGLKQQEKRKT
Sbjct: 241 VEHLNGSFLFDSMYAEDSEGNNLSYLPGVGELLETYKDKFVIICVNIFEYGLKQQEKRKT 300

Query: 301 ELDTFSECVREAIQENQEQGKRKIAKFEEKHLSSLSAIREELELPNIEKMILECSADISE 360
           ELDTFSECVREAIQENQEQGKRKIAKFEEKHLSSLSAIREELELPNIEKMILECSADISE
Sbjct: 301 ELDTFSECVREAIQENQEQGKRKIAKFEEKHLSSLSAIREELELPNIEKMILECSADISE 360

Query: 361 LFDALMTLEMQLVEQLEETINMFERNIVDMVGLFIENVQSLMAQCRDLENHHHEKLLEIS 420
           LFDALMTLEMQLVEQLEETINMFERNIVDMVGLFIENVQSLMAQCRDLENHHHEKLLEIS
Sbjct: 361 LFDALMTLEMQLVEQLEETINMFERNIVDMVGLFIENVQSLMAQCRDLENHHHEKLLEIS 420

Query: 421 ISTLEKIVEGDLDEDLPNDLRALFVDKDTIVNAVGASHDIHLLKIDNREDELVTRINSWC 480
           ISTLEKIVEGDLDEDLPNDLRALFVDKDTIVNAVGASHDIHLLKIDNREDELVTRINSWC
Sbjct: 421 ISTLEKIVEGDLDEDLPNDLRALFVDKDTIVNAVGASHDIHLLKIDNREDELVTRINSWC 480

Query: 481 TRLIDRIHKDEIMRNRKRVKEINQYIDHMQSELDNLECGDILD 523
           TRLIDRIHKDEIMRNRKRVKEINQYIDHMQSELDNLECGDILD
Sbjct: 481 TRLIDRIHKDEIMRNRKRVKEINQYIDHMQSELDNLECGDILD 523


>gi|194272222 leucine rich repeat containing 48 isoform a [Homo
           sapiens]
          Length = 523

 Score = 1035 bits (2677), Expect = 0.0
 Identities = 523/523 (100%), Positives = 523/523 (100%)

Query: 1   MNQPCNSMEPRVMDDDMLKLAVGDQGPQEEAGQLAKQEGILFKDVLSLQLDFRNILRIDN 60
           MNQPCNSMEPRVMDDDMLKLAVGDQGPQEEAGQLAKQEGILFKDVLSLQLDFRNILRIDN
Sbjct: 1   MNQPCNSMEPRVMDDDMLKLAVGDQGPQEEAGQLAKQEGILFKDVLSLQLDFRNILRIDN 60

Query: 61  LWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNR 120
           LWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNR
Sbjct: 61  LWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNR 120

Query: 121 ISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICA 180
           ISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICA
Sbjct: 121 ISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICA 180

Query: 181 YLPDLMYLDYRRIDDHTKKLAEAKHQYSIDELKHQENLMQAQLEDEQAQREELEKHKTAF 240
           YLPDLMYLDYRRIDDHTKKLAEAKHQYSIDELKHQENLMQAQLEDEQAQREELEKHKTAF
Sbjct: 181 YLPDLMYLDYRRIDDHTKKLAEAKHQYSIDELKHQENLMQAQLEDEQAQREELEKHKTAF 240

Query: 241 VEHLNGSFLFDSMYAEDSEGNNLSYLPGVGELLETYKDKFVIICVNIFEYGLKQQEKRKT 300
           VEHLNGSFLFDSMYAEDSEGNNLSYLPGVGELLETYKDKFVIICVNIFEYGLKQQEKRKT
Sbjct: 241 VEHLNGSFLFDSMYAEDSEGNNLSYLPGVGELLETYKDKFVIICVNIFEYGLKQQEKRKT 300

Query: 301 ELDTFSECVREAIQENQEQGKRKIAKFEEKHLSSLSAIREELELPNIEKMILECSADISE 360
           ELDTFSECVREAIQENQEQGKRKIAKFEEKHLSSLSAIREELELPNIEKMILECSADISE
Sbjct: 301 ELDTFSECVREAIQENQEQGKRKIAKFEEKHLSSLSAIREELELPNIEKMILECSADISE 360

Query: 361 LFDALMTLEMQLVEQLEETINMFERNIVDMVGLFIENVQSLMAQCRDLENHHHEKLLEIS 420
           LFDALMTLEMQLVEQLEETINMFERNIVDMVGLFIENVQSLMAQCRDLENHHHEKLLEIS
Sbjct: 361 LFDALMTLEMQLVEQLEETINMFERNIVDMVGLFIENVQSLMAQCRDLENHHHEKLLEIS 420

Query: 421 ISTLEKIVEGDLDEDLPNDLRALFVDKDTIVNAVGASHDIHLLKIDNREDELVTRINSWC 480
           ISTLEKIVEGDLDEDLPNDLRALFVDKDTIVNAVGASHDIHLLKIDNREDELVTRINSWC
Sbjct: 421 ISTLEKIVEGDLDEDLPNDLRALFVDKDTIVNAVGASHDIHLLKIDNREDELVTRINSWC 480

Query: 481 TRLIDRIHKDEIMRNRKRVKEINQYIDHMQSELDNLECGDILD 523
           TRLIDRIHKDEIMRNRKRVKEINQYIDHMQSELDNLECGDILD
Sbjct: 481 TRLIDRIHKDEIMRNRKRVKEINQYIDHMQSELDNLECGDILD 523


>gi|194272228 leucine rich repeat containing 48 isoform b [Homo
           sapiens]
          Length = 457

 Score =  874 bits (2257), Expect = 0.0
 Identities = 446/455 (98%), Positives = 446/455 (98%)

Query: 1   MNQPCNSMEPRVMDDDMLKLAVGDQGPQEEAGQLAKQEGILFKDVLSLQLDFRNILRIDN 60
           MNQPCNSMEPRVMDDDMLKLAVGDQGPQEEAGQLAKQEGILFKDVLSLQLDFRNILRIDN
Sbjct: 1   MNQPCNSMEPRVMDDDMLKLAVGDQGPQEEAGQLAKQEGILFKDVLSLQLDFRNILRIDN 60

Query: 61  LWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNR 120
           LWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNR
Sbjct: 61  LWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNR 120

Query: 121 ISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICA 180
           ISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICA
Sbjct: 121 ISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICA 180

Query: 181 YLPDLMYLDYRRIDDHTKKLAEAKHQYSIDELKHQENLMQAQLEDEQAQREELEKHKTAF 240
           YLPDLMYLDYRRIDDHTKKLAEAKHQYSIDELKHQENLMQAQLEDEQAQREELEKHKTAF
Sbjct: 181 YLPDLMYLDYRRIDDHTKKLAEAKHQYSIDELKHQENLMQAQLEDEQAQREELEKHKTAF 240

Query: 241 VEHLNGSFLFDSMYAEDSEGNNLSYLPGVGELLETYKDKFVIICVNIFEYGLKQQEKRKT 300
           VEHLNGSFLFDSMYAEDSEGNNLSYLPGVGELLETYKDKFVIICVNIFEYGLKQQEKRKT
Sbjct: 241 VEHLNGSFLFDSMYAEDSEGNNLSYLPGVGELLETYKDKFVIICVNIFEYGLKQQEKRKT 300

Query: 301 ELDTFSECVREAIQENQEQGKRKIAKFEEKHLSSLSAIREELELPNIEKMILECSADISE 360
           ELDTFSECVREAIQENQEQGKRKIAKFEEKHLSSLSAIREELELPNIEKMILECSADISE
Sbjct: 301 ELDTFSECVREAIQENQEQGKRKIAKFEEKHLSSLSAIREELELPNIEKMILECSADISE 360

Query: 361 LFDALMTLEMQLVEQLEETINMFERNIVDMVGLFIENVQSLMAQCRDLENHHHEKLLEIS 420
           LFDALMTLEMQLVEQLEETINMFERNIVDMVGLFIENVQSLMAQCRDLENHHHEKLLEIS
Sbjct: 361 LFDALMTLEMQLVEQLEETINMFERNIVDMVGLFIENVQSLMAQCRDLENHHHEKLLEIS 420

Query: 421 ISTLEKIVEGDLDEDLPNDLRALFVDKDTIVNAVG 455
           ISTLEKIVEGDLDEDLPNDLRA    K   V A G
Sbjct: 421 ISTLEKIVEGDLDEDLPNDLRAGRFQKFNYVEASG 455


>gi|194272226 leucine rich repeat containing 48 isoform b [Homo
           sapiens]
          Length = 457

 Score =  874 bits (2257), Expect = 0.0
 Identities = 446/455 (98%), Positives = 446/455 (98%)

Query: 1   MNQPCNSMEPRVMDDDMLKLAVGDQGPQEEAGQLAKQEGILFKDVLSLQLDFRNILRIDN 60
           MNQPCNSMEPRVMDDDMLKLAVGDQGPQEEAGQLAKQEGILFKDVLSLQLDFRNILRIDN
Sbjct: 1   MNQPCNSMEPRVMDDDMLKLAVGDQGPQEEAGQLAKQEGILFKDVLSLQLDFRNILRIDN 60

Query: 61  LWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNR 120
           LWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNR
Sbjct: 61  LWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNR 120

Query: 121 ISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICA 180
           ISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICA
Sbjct: 121 ISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICA 180

Query: 181 YLPDLMYLDYRRIDDHTKKLAEAKHQYSIDELKHQENLMQAQLEDEQAQREELEKHKTAF 240
           YLPDLMYLDYRRIDDHTKKLAEAKHQYSIDELKHQENLMQAQLEDEQAQREELEKHKTAF
Sbjct: 181 YLPDLMYLDYRRIDDHTKKLAEAKHQYSIDELKHQENLMQAQLEDEQAQREELEKHKTAF 240

Query: 241 VEHLNGSFLFDSMYAEDSEGNNLSYLPGVGELLETYKDKFVIICVNIFEYGLKQQEKRKT 300
           VEHLNGSFLFDSMYAEDSEGNNLSYLPGVGELLETYKDKFVIICVNIFEYGLKQQEKRKT
Sbjct: 241 VEHLNGSFLFDSMYAEDSEGNNLSYLPGVGELLETYKDKFVIICVNIFEYGLKQQEKRKT 300

Query: 301 ELDTFSECVREAIQENQEQGKRKIAKFEEKHLSSLSAIREELELPNIEKMILECSADISE 360
           ELDTFSECVREAIQENQEQGKRKIAKFEEKHLSSLSAIREELELPNIEKMILECSADISE
Sbjct: 301 ELDTFSECVREAIQENQEQGKRKIAKFEEKHLSSLSAIREELELPNIEKMILECSADISE 360

Query: 361 LFDALMTLEMQLVEQLEETINMFERNIVDMVGLFIENVQSLMAQCRDLENHHHEKLLEIS 420
           LFDALMTLEMQLVEQLEETINMFERNIVDMVGLFIENVQSLMAQCRDLENHHHEKLLEIS
Sbjct: 361 LFDALMTLEMQLVEQLEETINMFERNIVDMVGLFIENVQSLMAQCRDLENHHHEKLLEIS 420

Query: 421 ISTLEKIVEGDLDEDLPNDLRALFVDKDTIVNAVG 455
           ISTLEKIVEGDLDEDLPNDLRA    K   V A G
Sbjct: 421 ISTLEKIVEGDLDEDLPNDLRAGRFQKFNYVEASG 455


>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
          Length = 2325

 Score = 97.4 bits (241), Expect = 3e-20
 Identities = 132/552 (23%), Positives = 237/552 (42%), Gaps = 79/552 (14%)

Query: 33  QLAKQEGILFKDVLSLQLDF---RNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHL 89
           +L KQ+ +     L+L L     +    I+NL +   L  L L  N+I KIE L+ L  L
Sbjct: 90  KLTKQDNLALIKSLNLSLSKDGGKKFKYIENLEKCVKLEVLNLSYNLIGKIEKLDKLLKL 149

Query: 90  VWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKIDSL--DALVKLQVLSLGNNRIDNMM 147
             L+LS+N I  IEG++ + NL+ L+L  N I  I       L  L+VL+L  N+I ++ 
Sbjct: 150 RELNLSYNKISKIEGIENMCNLQKLNLAGNEIEHIPVWLGKKLKSLRVLNLKGNKISSLQ 209

Query: 148 NIIYLRRFKCLRTLSLSRNPISEAEDYKMFICAYLPDLMYLDYRRIDDHTKKLAEAKHQY 207
           +I  L+  + L +L L  NP+     Y  F   +L  L  L+ + +   T+   EA  ++
Sbjct: 210 DISKLKPLQDLISLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVT--TQDRQEAFERF 267

Query: 208 SIDELKHQENLMQAQLEDEQAQREELEKHKTAFVEH------LNGSFLFDSMYAEDSEGN 261
           S++E++     ++  LE +  + EEL+  +T F+E       LN S   ++M  + S   
Sbjct: 268 SLEEVER----LERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEE 323

Query: 262 NLSYLPGVGELLETYKDKFVIICVNIFEYGLKQQ-------------EKRKTELDTFSEC 308
             S L    ELL+    +    C    +Y L+Q+                 +E     + 
Sbjct: 324 LKSDLNTKNELLKQKTIELTRACQK--QYELEQELAFYKIDAKFEPLNYYPSEYAEIDKA 381

Query: 309 VREAIQENQEQGKRKIAKFEEKHLSSLSAIR-------EEL---------------ELPN 346
             E+    + + KR +   E   + S  A++       E+L               +L +
Sbjct: 382 PDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLED 441

Query: 347 IEKMILECSADISELFDALMTLEMQLV------EQLEETINMFERNIVDMVGLF------ 394
            EK I      +SEL D +   E Q++      +QLEE I + + +      L+      
Sbjct: 442 KEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGR 501

Query: 395 IENVQSLMAQCRDLENHHHEKLLEISISTLE----KIVEGDLDEDLP--NDLRALFVDKD 448
           ++ V  L  +  DLE    ++  EI+    E    +I    LD   P  + ++A    K+
Sbjct: 502 LQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKE 561

Query: 449 TIVNAVGASHDIHLLKIDNREDELVTRINSWCTRLID---RIHKDEIMRNRKRVKEINQY 505
             ++ +   +     ++++R DE+++RI      + D   ++ + +I  N    K++   
Sbjct: 562 QQLDIMNKQYQ----QLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGV 617

Query: 506 IDHMQSELDNLE 517
           I  +Q  L  ++
Sbjct: 618 ISGLQEYLGTIK 629



 Score = 31.2 bits (69), Expect = 2.4
 Identities = 51/276 (18%), Positives = 115/276 (41%), Gaps = 52/276 (18%)

Query: 292  LKQQEKRKTELDTFSECVREAIQENQEQGKRKIAKFEEKHLSSLSAIREELELPNIEKMI 351
            L+Q  K KTEL    + ++    E Q    +   +  E   + ++ + E+LEL N++++ 
Sbjct: 1688 LRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQIS 1747

Query: 352  LECSADISELFDAL---------MTLEMQLVEQLEETINMFERNIVDMVGLF---IENVQ 399
             +   +I      L         MT E + ++   E ++  + ++ +   ++   +   +
Sbjct: 1748 QQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTK 1807

Query: 400  SLMAQCRD---LENHHHEKLLEISISTLEKIVEGDLDED---LPNDLRAL---FVDKDTI 450
             ++A   +   +E  + EK LE+++  L++ ++  L+ D   L ND+ A+     +K   
Sbjct: 1808 RVLAAAEENSKMEQSNLEK-LELNVRKLQQELD-QLNRDKLSLHNDISAMQQQLQEKREA 1865

Query: 451  VNAV-----GASHDIHLLKID------------NREDELVTRINSWCTRLID-------- 485
            VN++          ++L K D            + +  L   I+ W  R  D        
Sbjct: 1866 VNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETK 1925

Query: 486  ----RIHKDEIMRNRKRVKEINQYIDHMQSELDNLE 517
                ++ ++EI  N+ ++ +       +Q E ++ E
Sbjct: 1926 QQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEE 1961


>gi|4506013 protein phosphatase 1, regulatory subunit 7 [Homo
           sapiens]
          Length = 360

 Score = 92.4 bits (228), Expect = 9e-19
 Identities = 61/142 (42%), Positives = 89/142 (62%), Gaps = 4/142 (2%)

Query: 33  QLAKQEGI-LFKDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVW 91
           ++ K EG  + K V +L L    I  I+NL + ++LR+L L +N I+KIE LE L  L  
Sbjct: 87  RIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEI 146

Query: 92  LDLSFNNIETIEGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIY 151
           LD+SFN +  IEG+D L  L+ L L NN+ISKI++L  L +LQ+L LG+NRI  + NI  
Sbjct: 147 LDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDT 206

Query: 152 LRRFKCLRTLSLSRNPISEAED 173
           L     L +L L +N I++ ++
Sbjct: 207 LTN---LESLFLGKNKITKLQN 225



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 68/202 (33%), Positives = 100/202 (49%), Gaps = 18/202 (8%)

Query: 48  LQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDT 107
           L + F  +  I+ + +   L+KL L NN I KIE L NL  L  L+L  N I  IE +DT
Sbjct: 147 LDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDT 206

Query: 108 LVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNR---IDNMMNIIYLRRFKCLRTLSLS 164
           L NLE L L  N+I+K+ +LDAL  L VLS+ +NR   I+ + N++ LR       L LS
Sbjct: 207 LTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRE------LYLS 260

Query: 165 RNPISEAEDYKMFICAYLPDLMYLDYRRIDD--HTKKLAE-------AKHQYSIDELKHQ 215
            N I   E  +      + D+     ++I++  H  +L E        +    +DELK  
Sbjct: 261 HNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGA 320

Query: 216 ENLMQAQLEDEQAQREELEKHK 237
            +L    LE    Q++   + K
Sbjct: 321 RSLETVYLERNPLQKDPQYRRK 342



 Score = 85.9 bits (211), Expect = 8e-17
 Identities = 50/143 (34%), Positives = 80/143 (55%)

Query: 47  SLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLD 106
           SL L    I ++ NL    NL  L + +N + KIEGL+NL +L  L LS N IE IEGL+
Sbjct: 212 SLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLE 271

Query: 107 TLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRN 166
               L  L + +NRI KI+++  L +LQ   + +N +++  ++  L+  + L T+ L RN
Sbjct: 272 NNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERN 331

Query: 167 PISEAEDYKMFICAYLPDLMYLD 189
           P+ +   Y+  +   LP +  +D
Sbjct: 332 PLQKDPQYRRKVMLALPSVRQID 354


>gi|21389483 leucine-rich repeats and guanylate kinase domain
           containing [Homo sapiens]
          Length = 825

 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 64/183 (34%), Positives = 90/183 (49%), Gaps = 1/183 (0%)

Query: 48  LQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDT 107
           L LD   I  I  L    NL  L L NN I  I GL  L   + L LS N IE I GL+ 
Sbjct: 220 LILDGNEIEEISGLEMCNNLIHLSLANNKITTINGLNKLPIKI-LCLSNNQIEMITGLED 278

Query: 108 LVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNP 167
           L  L++L L +N+IS +  L+    L+V++L +N+I  +  I Y++    LR L+L  NP
Sbjct: 279 LKALQNLDLSHNQISSLQGLENHDLLEVINLEDNKIAELREIEYIKNLPILRVLNLLENP 338

Query: 168 ISEAEDYKMFICAYLPDLMYLDYRRIDDHTKKLAEAKHQYSIDELKHQENLMQAQLEDEQ 227
           I E  +Y  F+   L  L  LD ++I    K  A  K+    + +  Q++L        Q
Sbjct: 339 IQEKSEYWFFVIFMLLRLTELDQKKIKVEEKVSAVNKYDPPPEVVAAQDHLTHVVNSVMQ 398

Query: 228 AQR 230
            QR
Sbjct: 399 PQR 401



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 38/124 (30%), Positives = 60/124 (48%), Gaps = 3/124 (2%)

Query: 46  LSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGL 105
           L+L L   N++ +  L  + +L+KL L  N IE +  +  + +L+ L+ S NN+ T    
Sbjct: 130 LNLTLSGCNLIDVSILCGYVHLQKLDLSANKIEDLSCVSCMPYLLELNASQNNLTTFFNF 189

Query: 106 DTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSR 165
               NL+     +N+IS+I  L A   L  L L  N I+ +     L     L  LSL+ 
Sbjct: 190 KPPKNLKKADFSHNQISEICDLSAYHALTKLILDGNEIEEISG---LEMCNNLIHLSLAN 246

Query: 166 NPIS 169
           N I+
Sbjct: 247 NKIT 250


>gi|157674358 leucine rich repeat containing 50 [Homo sapiens]
          Length = 725

 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 59/171 (34%), Positives = 89/171 (52%), Gaps = 7/171 (4%)

Query: 24  DQGPQ---EEAGQLAKQEGILFKDVLS--LQLDFRNILRIDNLWQFENLRKLQLDNNIIE 78
           D+GP+       +L KQ  +     L+  L L F+   RI+NL ++  LR L L +N I+
Sbjct: 83  DRGPRMTKSSLQKLCKQHKLYITPALNDTLYLHFKGFDRIENLEEYTGLRCLWLQSNGIQ 142

Query: 79  KIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSL 138
           KIE LE    L  L L  N +  IE L+ L  L+ L+L NN I  I++L  L  L  L +
Sbjct: 143 KIENLEAQTELRCLFLQMNLLRKIENLEPLQKLDALNLSNNYIKTIENLSCLPVLNTLQM 202

Query: 139 GNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICAYLPDLMYLD 189
            +N ++ + +I +L+    L  L LS N +S+ E   + I   +PDL  L+
Sbjct: 203 AHNHLETVEDIQHLQECLRLCVLDLSHNKLSDPE--ILSILESMPDLRVLN 251


>gi|55743114 leucine rich repeat containing 49 [Homo sapiens]
          Length = 686

 Score = 79.3 bits (194), Expect = 8e-15
 Identities = 56/141 (39%), Positives = 78/141 (55%), Gaps = 5/141 (3%)

Query: 33  QLAKQEGILFKDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWL 92
           Q + +E IL+ D LSL+     +  I N    ++LR L   +N I +I+ + NL  L+ L
Sbjct: 82  QRSSEEKILYSDRLSLERQKLTVCPIIN--GEDHLRLLNFQHNFITRIQNISNLQKLISL 139

Query: 93  DLSFNNIETIEGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYL 152
           DL  N IE I GL TL  L  L L  NRI KI +L+ L  L VL L  N+I  + NI +L
Sbjct: 140 DLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLKSLDVLDLHGNQITKIENINHL 199

Query: 153 RRFKCLRTLSLSRNPISEAED 173
                LR L+L+RN +S  ++
Sbjct: 200 CE---LRVLNLARNFLSHVDN 217



 Score = 72.8 bits (177), Expect = 7e-13
 Identities = 54/197 (27%), Positives = 101/197 (51%), Gaps = 5/197 (2%)

Query: 48  LQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDT 107
           L L    I +I NL   ++L  L L  N I KIE + +L  L  L+L+ N +  ++ L+ 
Sbjct: 161 LLLGKNRIKKISNLENLKSLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNG 220

Query: 108 LVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNP 167
           L +L +L+L +N+I+ +  +D L  LQ L L  N I +  ++  L     L  ++   NP
Sbjct: 221 LDSLTELNLRHNQITFVRDVDNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNP 280

Query: 168 ISEAEDYKMFICAYLPDLMYLDYRRIDDHTKKLAE--AKHQYSIDELKHQENLMQAQLE- 224
           I++   YK  +   +  L  LD +RI +  +++A   AK +       H+++L++ +   
Sbjct: 281 IAQESWYKHTVLQNMMQLRQLDMKRITEEERRMASVLAKKEEEKKRESHKQSLLKEKKRL 340

Query: 225 --DEQAQREELEKHKTA 239
             +  A++ +L++ + A
Sbjct: 341 TINNVARQWDLQQQRVA 357


>gi|117414162 sodium channel associated protein 2 isoform a [Homo
           sapiens]
          Length = 1032

 Score = 72.4 bits (176), Expect = 9e-13
 Identities = 54/165 (32%), Positives = 82/165 (49%), Gaps = 9/165 (5%)

Query: 47  SLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLD 106
           ++ L   NI +I+ +    NL+ L L +N I +IEGL  L  L  L+LS N I  +EGL+
Sbjct: 47  AVNLHCNNISKIEAIDHIWNLQHLDLSSNQISRIEGLNTLTKLCTLNLSCNLITKVEGLE 106

Query: 107 TLVNLEDLSLFNNRISKIDSLDAL----VKLQVLSLGNNRIDNMMNIIY-LRRFKCLRTL 161
            L+NL  L++  N I  +  L  L     KL+ + L +NRID++ +++  +     L  L
Sbjct: 107 ELINLTRLNVSYNHIDDLSGLIPLHGIKHKLRYIDLHSNRIDSIHHLLQCMVGLHFLTNL 166

Query: 162 SLSR----NPISEAEDYKMFICAYLPDLMYLDYRRIDDHTKKLAE 202
            L +    NP+     Y+  I   LP L  LD + I      L E
Sbjct: 167 ILEKDGDDNPVCRLPGYRAVILQTLPQLRILDCKNIFGEPVNLTE 211



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 43/117 (36%), Positives = 64/117 (54%), Gaps = 1/117 (0%)

Query: 53  RNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLE 112
           + +  I  L     L  + L  N I KIE ++++ +L  LDLS N I  IEGL+TL  L 
Sbjct: 31  KGLQSISELSLDSTLHAVNLHCNNISKIEAIDHIWNLQHLDLSSNQISRIEGLNTLTKLC 90

Query: 113 DLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFK-CLRTLSLSRNPI 168
            L+L  N I+K++ L+ L+ L  L++  N ID++  +I L   K  LR + L  N I
Sbjct: 91  TLNLSCNLITKVEGLEELINLTRLNVSYNHIDDLSGLIPLHGIKHKLRYIDLHSNRI 147



 Score = 29.6 bits (65), Expect = 7.0
 Identities = 38/168 (22%), Positives = 72/168 (42%), Gaps = 29/168 (17%)

Query: 292 LKQQEKRKTELDTFSECVREAIQENQEQGKRKIAKFEEKHLSSLSAIREELELPNIEKMI 351
           LK+QE RK EL+T  E   +A  + Q+   ++IAK E+KH   +   +E++++ + + M 
Sbjct: 583 LKEQEHRK-ELET-REFFTDA--DFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYM- 637

Query: 352 LECSADISELFDALMTLEMQLVEQLEETINMFERNIVDMVGLFI------ENVQSLMAQC 405
                D+   F   +T+E +  + +++        +       I          SL+   
Sbjct: 638 -----DLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDL 692

Query: 406 RDLENHHHEKLLEIS-------------ISTLEKIVEGDLDEDLPNDL 440
             +      KL E+S             I+TLE ++E D  + +  +L
Sbjct: 693 TCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIEL 740


>gi|66472382 nischarin [Homo sapiens]
          Length = 1504

 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 45/136 (33%), Positives = 74/136 (54%), Gaps = 2/136 (1%)

Query: 47  SLQLDFRNILRID-NLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGL 105
           +L L   +I  ID ++     +  L L +N +  ++ L++L +LV LDLS+N + ++EGL
Sbjct: 291 TLDLSHNSISEIDESVKLIPKIEFLDLSHNGLLVVDNLQHLYNLVHLDLSYNKLSSLEGL 350

Query: 106 DT-LVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLS 164
            T L N++ L+L  N +  +  L  L  L  L L +NRI+ M  +  +    CL  +SL 
Sbjct: 351 HTKLGNIKTLNLAGNLLESLSGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEHVSLL 410

Query: 165 RNPISEAEDYKMFICA 180
            NP+S   DY+  + A
Sbjct: 411 NNPLSIIPDYRTKVLA 426


>gi|31377705 centrosomal protein 97kDa [Homo sapiens]
          Length = 865

 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 54/191 (28%), Positives = 90/191 (47%), Gaps = 31/191 (16%)

Query: 30  EAGQLAKQEGI-LFKDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAH 88
           +  Q+ K E +   K ++ L +    ++R+  + +   LR L L +N I  +EGL+ L H
Sbjct: 44  DKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVEGLKELVH 103

Query: 89  LVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKIDSLDALVKLQ-------------- 134
           L WL+L+ NN++ +E +++   L+ L L +N IS+I  L  LV L+              
Sbjct: 104 LEWLNLAGNNLKAMEQINSCTALQHLDLSDNNISQIGDLSKLVSLKTLLLHGNIITSLRM 163

Query: 135 ----------VLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAE------DYKMFI 178
                     +LSL  N I ++  I +L     L  LS+  NP   A       DY+ +I
Sbjct: 164 APAYLPRSLAILSLAENEIRDLNEISFLASLTELEQLSIMNNPCVMATPSIPGFDYRPYI 223

Query: 179 CAYLPDLMYLD 189
            ++  +L  LD
Sbjct: 224 VSWCLNLRVLD 234



 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 46/140 (32%), Positives = 76/140 (54%), Gaps = 7/140 (5%)

Query: 44  DVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIE 103
           D+ +L LD   I++++NL + + L +L + NN + ++ G+  L  L  L+L  N+I  +E
Sbjct: 37  DIHTLILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVE 96

Query: 104 GLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSL 163
           GL  LV+LE L+L  N +  ++ +++   LQ L L +N   N+  I  L +   L+TL L
Sbjct: 97  GLKELVHLEWLNLAGNNLKAMEQINSCTALQHLDLSDN---NISQIGDLSKLVSLKTLLL 153

Query: 164 SRNPISEAEDYKMFICAYLP 183
             N I+          AYLP
Sbjct: 154 HGNIITSLR----MAPAYLP 169


>gi|31621309 leucine rich repeat containing 6 [Homo sapiens]
          Length = 466

 Score = 69.3 bits (168), Expect = 8e-12
 Identities = 75/263 (28%), Positives = 122/263 (46%), Gaps = 25/263 (9%)

Query: 66  NLRKLQLDNNIIEKIEGLENLAH-LVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKI 124
           +L +L L    IE++E ++     L  L L  N I  IE +  L  LE L+L  N I KI
Sbjct: 22  SLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKI 81

Query: 125 DSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICAYLPD 184
           ++L+   +L  L L  N I  + +I  L+    L+ L L  NP +  + Y+ F+ A LP 
Sbjct: 82  ENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQ 141

Query: 185 LMYLDYRRIDDHTKKLAEAKHQYSIDE--LKHQEN---LMQAQLEDEQAQREELEKHK-- 237
           L +LD + I+   +   +A   YS+ E  ++ QE    L +A+L+ E+AQR+  E+ K  
Sbjct: 142 LKWLDGKEIEPSER--IKALQDYSVIEPQIREQEKDHCLKRAKLK-EEAQRKHQEEDKNE 198

Query: 238 -------------TAFVEHLNGSFLFDSMYAEDSEGNNLSYLPGVGELLETYKDKFVIIC 284
                        T     L+     D + A D+E +N   L    + LE +    +   
Sbjct: 199 DKRSNAGFDGRWYTDINATLSSLESKDHLQAPDTEEHNTKKLDNSEDDLEFWNKPCLFTP 258

Query: 285 VNIFEYGLKQQEKRKTELDTFSE 307
            +  E  L+  EK++ + +  SE
Sbjct: 259 ESRLE-TLRHMEKQRKKQEKLSE 280


>gi|239752518 PREDICTED: similar to leucine rich repeat containing
           50, partial [Homo sapiens]
          Length = 489

 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 46/157 (29%), Positives = 82/157 (52%), Gaps = 2/157 (1%)

Query: 66  NLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKID 125
           NL  L L  N I KIE + +L  L  L+L+ N +  ++ L+ L +L +L+L +N+I+ + 
Sbjct: 4   NLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVR 63

Query: 126 SLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICAYLPDL 185
            +D L  LQ L L  N I +  ++  L     L  ++   NPI++   YK  +   +  L
Sbjct: 64  DVDNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQNMMQL 123

Query: 186 MYLDYRRIDDHTKKLAE--AKHQYSIDELKHQENLMQ 220
             LD +RI +  +++A   AK +       H+++L++
Sbjct: 124 RQLDMKRITEEERRMASVLAKKEEEKKRESHKQSLLK 160


>gi|206725447 leucine rich repeat containing 23 isoform a [Homo
           sapiens]
          Length = 343

 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 60/199 (30%), Positives = 94/199 (47%), Gaps = 5/199 (2%)

Query: 33  QLAKQEGILFKDVLSLQLDFRNILRIDNL--WQFENLRKLQLDNNIIEKIEGLENLAHLV 90
           Q+   EGI    + +L L   +I  +  L   +  +L  ++L  N +E   G+ NL  L 
Sbjct: 145 QITDTEGISHPRLETLNLKGNSIHMVTGLDPEKLISLHTVELRGNQLESTLGI-NLPKLK 203

Query: 91  WLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKIDSLDALVK-LQVLSLGNNRIDNMMNI 149
            L L+ N ++ +EGL+ L NL  L L +N+I  +      +K LQ L+L  N + N+  +
Sbjct: 204 NLYLAQNMLKKVEGLEDLSNLTTLHLRDNQIDTLSGFSREMKSLQYLNLRGNMVANLGEL 263

Query: 150 IYLRRFKCLRTLSLSRNPISEAEDYKMFICAYLPDLMYLDYRRIDDHTKKLAEAKHQYSI 209
             LR    LR L L  NP ++   Y+      +P L  LD    ++  +  A+   Q  +
Sbjct: 264 AKLRDLPKLRALVLLDNPCTDETSYRQEALVQMPYLERLDKEFYEEEERAEADVIRQ-RL 322

Query: 210 DELKHQENLMQAQLEDEQA 228
            E K QE   Q  LE EQ+
Sbjct: 323 KEEKEQEPEPQRDLEPEQS 341


>gi|42542396 leucine rich repeat containing 23 isoform a [Homo
           sapiens]
          Length = 343

 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 60/199 (30%), Positives = 94/199 (47%), Gaps = 5/199 (2%)

Query: 33  QLAKQEGILFKDVLSLQLDFRNILRIDNL--WQFENLRKLQLDNNIIEKIEGLENLAHLV 90
           Q+   EGI    + +L L   +I  +  L   +  +L  ++L  N +E   G+ NL  L 
Sbjct: 145 QITDTEGISHPRLETLNLKGNSIHMVTGLDPEKLISLHTVELRGNQLESTLGI-NLPKLK 203

Query: 91  WLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKIDSLDALVK-LQVLSLGNNRIDNMMNI 149
            L L+ N ++ +EGL+ L NL  L L +N+I  +      +K LQ L+L  N + N+  +
Sbjct: 204 NLYLAQNMLKKVEGLEDLSNLTTLHLRDNQIDTLSGFSREMKSLQYLNLRGNMVANLGEL 263

Query: 150 IYLRRFKCLRTLSLSRNPISEAEDYKMFICAYLPDLMYLDYRRIDDHTKKLAEAKHQYSI 209
             LR    LR L L  NP ++   Y+      +P L  LD    ++  +  A+   Q  +
Sbjct: 264 AKLRDLPKLRALVLLDNPCTDETSYRQEALVQMPYLERLDKEFYEEEERAEADVIRQ-RL 322

Query: 210 DELKHQENLMQAQLEDEQA 228
            E K QE   Q  LE EQ+
Sbjct: 323 KEEKEQEPEPQRDLEPEQS 341


>gi|164607156 axonemal dynein light chain 1 [Homo sapiens]
          Length = 190

 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 38/112 (33%), Positives = 57/112 (50%), Gaps = 1/112 (0%)

Query: 60  NLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVN-LEDLSLFN 118
           +L    N  KL L  N IEKI  L  L +L  L L  NNI+ + GL+ + + LE+L +  
Sbjct: 43  SLSMLANCEKLSLSTNCIEKIANLNGLKNLRILSLGRNNIKNLNGLEAVGDTLEELWISY 102

Query: 119 NRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISE 170
           N I K+  +  + KL++L + NN + +    + L    CL  L    NP+ E
Sbjct: 103 NFIEKLKGIHIMKKLKILYMSNNLVKDWAEFVKLAELPCLEDLVFVGNPLEE 154


>gi|5454088 acidic (leucine-rich) nuclear phosphoprotein 32 family,
           member B [Homo sapiens]
          Length = 251

 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 49/174 (28%), Positives = 87/174 (50%), Gaps = 5/174 (2%)

Query: 67  LRKLQLDN--NIIEKIEGLE-NLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRI-S 122
           +R+L LDN  +   KIEGL     +L +L L    + ++  L  L  L+ L L  NRI  
Sbjct: 19  VRELVLDNCKSNDGKIEGLTAEFVNLEFLSLINVGLISVSNLPKLPKLKKLELSENRIFG 78

Query: 123 KIDSL-DALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICAY 181
            +D L + L  L  L+L  N++ ++  +  L++ +CL++L L    ++   DY+  +   
Sbjct: 79  GLDMLAEKLPNLTHLNLSGNKLKDISTLEPLKKLECLKSLDLFNCEVTNLNDYRESVFKL 138

Query: 182 LPDLMYLDYRRIDDHTKKLAEAKHQYSIDELKHQENLMQAQLEDEQAQREELEK 235
           LP L YLD    +D     ++A+     +E + +E   +   +DE  + EE ++
Sbjct: 139 LPQLTYLDGYDREDQEAPDSDAEVDGVDEEEEDEEGEDEEDEDDEDGEEEEFDE 192


>gi|50593002 small nuclear ribonucleoprotein polypeptide A' [Homo
           sapiens]
          Length = 255

 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 44/138 (31%), Positives = 72/138 (52%), Gaps = 3/138 (2%)

Query: 68  RKLQLDNNIIEKIEGL-ENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKI-D 125
           R+L L    I  IE L   L     +D S N I  ++G   L  L+ L + NNRI +I +
Sbjct: 22  RELDLRGYKIPVIENLGATLDQFDAIDFSDNEIRKLDGFPLLRRLKTLLVNNNRICRIGE 81

Query: 126 SLD-ALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICAYLPD 184
            LD AL  L  L L NN +  + ++  L   K L  LS+ RNP++  + Y++++   +P 
Sbjct: 82  GLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSILRNPVTNKKHYRLYVIYKVPQ 141

Query: 185 LMYLDYRRIDDHTKKLAE 202
           +  LD++++    ++ AE
Sbjct: 142 VRVLDFQKVKLKERQEAE 159


>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
          Length = 1537

 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 37/102 (36%), Positives = 59/102 (57%), Gaps = 7/102 (6%)

Query: 63  QFENLRKLQLDNNIIEKIEG-LENLAHLVWLDLSFNNIETIE-GLDTLVNLEDLSLFNNR 120
           Q +NLR+L +DNN ++ + G +  L  LV+LD+S N IET++  +     LEDL L +N 
Sbjct: 205 QIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNM 264

Query: 121 ISKI-DSLDALVKLQVLSLGNNRIDNMMNII----YLRRFKC 157
           + ++ DS+  L KL  L + +N++  + N I     L  F C
Sbjct: 265 LQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDC 306



 Score = 29.3 bits (64), Expect = 9.2
 Identities = 26/84 (30%), Positives = 41/84 (48%), Gaps = 4/84 (4%)

Query: 92  LDLSFNNIETI-EGLDTLVNLEDLSLFNNRISKIDS-LDALVKLQVLSLGNNRIDNMMNI 149
           L L  N IE + + L     L  LS+ +N +S + + + +LV L+ L +  N +      
Sbjct: 51  LYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPEN 110

Query: 150 IYLRRFKCLRTLSLSRNPISEAED 173
           I  +  KCL  +  S NPIS+  D
Sbjct: 111 I--KCCKCLTIIEASVNPISKLPD 132


>gi|5453880 acidic (leucine-rich) nuclear phosphoprotein 32 family,
           member A [Homo sapiens]
          Length = 249

 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 55/212 (25%), Positives = 97/212 (45%), Gaps = 29/212 (13%)

Query: 66  NLRKLQLDNNIIE--KIEGL-ENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRIS 122
           ++++L LDN+     K+EGL +    L +L      + +I  L  L  L+ L L +NR+S
Sbjct: 18  DVKELVLDNSRSNEGKLEGLTDEFEELEFLSTINVGLTSIANLPKLNKLKKLELSDNRVS 77

Query: 123 KIDSLDALVK----LQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFI 178
               L+ L +    L  L+L  N+I ++  I  L++ + L++L L    ++   DY+  +
Sbjct: 78  --GGLEVLAEKCPNLTHLNLSGNKIKDLSTIEPLKKLENLKSLDLFNCEVTNLNDYRENV 135

Query: 179 CAYLPDLMYLDYRRIDDHTKKLAEAK--------HQYSIDELKHQENLMQAQLEDEQAQR 230
              LP L YLD    DD     ++A+         +   DE ++ E+    + E+++ + 
Sbjct: 136 FKLLPQLTYLDGYDRDDKEAPDSDAEGYVEGLDDEEEDEDEEEYDEDAQVVEDEEDEDEE 195

Query: 231 EELEKHKTAFVEHLNGSFLFDSMYAEDSEGNN 262
           EE E+   +  E             ED EG N
Sbjct: 196 EEGEEEDVSGEEE------------EDEEGYN 215


>gi|15529980 leucine rich repeat containing 46 [Homo sapiens]
          Length = 321

 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 61/221 (27%), Positives = 99/221 (44%), Gaps = 33/221 (14%)

Query: 30  EAGQLAKQEGILFKDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHL 89
           E G+L+++      ++ +++LD   I  I NL   +NL  L L  N   KI+ +ENLA  
Sbjct: 31  EDGELSEKMFHTLDELQTVRLDREGITTIRNLEGLQNLHSLYLQGN---KIQQIENLA-- 85

Query: 90  VWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNI 149
                             + +L  LSL  N+I ++++L  L  LQ L L  N I+ +   
Sbjct: 86  -----------------CIPSLRFLSLAGNQIRQVENLLDLPCLQFLDLSENLIETLK-- 126

Query: 150 IYLRRF-KCLRTLSLSRNPISEAEDYKMFICAYLPDLMYLDYRRIDDH--TKKLAEAKHQ 206
             L  F + L  L+LS N  +  + Y+  +   LP L+ LD + + +   + +  EA   
Sbjct: 127 --LDEFPQSLLILNLSGNSCTNQDGYRELVTEALPLLLDLDGQPVVERWISDEEDEASSD 184

Query: 207 YSIDELKH---QENLMQAQLEDEQAQREELEKHKTAFVEHL 244
               EL      E     +LE E ++  E  + +TA  EHL
Sbjct: 185 EEFPELSGPFCSERGFLKELEQELSRHRE-HRQQTALTEHL 224


>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
           isoform 2 [Homo sapiens]
          Length = 1119

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 47/150 (31%), Positives = 79/150 (52%), Gaps = 7/150 (4%)

Query: 46  LSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENL-AHLVWLDLSFNNIETI-- 102
           L L  +  + ++  ++   ++LR+++L+NN +E I  L  + A++  L L+ N I  I  
Sbjct: 79  LDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILP 138

Query: 103 EGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLS 162
           E L    +LE L L +N IS++ +    ++L+ L L +NR+ +M    +      L  L 
Sbjct: 139 EHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLK 198

Query: 163 LSRNPISEAEDYKMFICAYLPDLMYLDYRR 192
           L+RN IS A   KMF    LP L +L+  R
Sbjct: 199 LNRNRIS-AIPPKMF---KLPQLQHLELNR 224



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 41/114 (35%), Positives = 56/114 (49%), Gaps = 7/114 (6%)

Query: 62  WQFENLRKLQLD-NNIIEKIEG-LENLAHLVWLDLSFNNIETI--EGLDTLVNLEDLSLF 117
           W   N+  LQLD NN+ E  +G L  L  L  L LS N I  I  +  +    L +L L 
Sbjct: 260 WGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLT 319

Query: 118 NNRISKID--SLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPIS 169
            N +S++D  S   L  L  L +GNNR+  + +  + R    L+TL L  N IS
Sbjct: 320 FNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAF-RGLSSLKTLDLKNNEIS 372


>gi|120953300 leucine-rich repeats and IQ motif containing 1 isoform 1
            [Homo sapiens]
          Length = 1722

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 53/203 (26%), Positives = 98/203 (48%), Gaps = 9/203 (4%)

Query: 61   LWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNR 120
            L   +NL++L LD+N +   +GL +   +V+LD S N++  +EG++    L+ L L  N 
Sbjct: 965  LESLKNLQQLILDHNQLINTKGLCDTPTIVYLDCSHNHLTDVEGVENCGLLQILKLQGNY 1024

Query: 121  ISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICA 180
            +S++ SL+ LV L+ L L +N I + +          L+ +++S+N +++      F+  
Sbjct: 1025 LSELPSLENLVLLRELHLDDNSI-STVEAFSSYWLPLLQNITISQNSLTKIVPLFHFVSL 1083

Query: 181  YLPDLMYLDYRRIDDHTKKLAEAKHQYSIDELKHQENLMQAQLEDEQAQREELEKHKTAF 240
               + + + +  + D    +      YS+ EL    +L    L  E   R+ L K   A 
Sbjct: 1084 ---EKLDVSHNCLSDLKSAIKWFDACYSLHEL----SLTGNPLLQETNWRDSLLKVLPA- 1135

Query: 241  VEHLNGSFLFDSMYAEDSEGNNL 263
            +  LNG+ L  +  +   E N L
Sbjct: 1136 LRILNGNILNSNSESRTEEHNQL 1158



 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 39/142 (27%), Positives = 67/142 (47%), Gaps = 6/142 (4%)

Query: 43   KDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETI 102
            K++  L LD   ++    L     +  L   +N +  +EG+EN   L  L L  N +  +
Sbjct: 969  KNLQQLILDHNQLINTKGLCDTPTIVYLDCSHNHLTDVEGVENCGLLQILKLQGNYLSEL 1028

Query: 103  EGLDTLVNLEDLSLFNNRISKIDSLDA--LVKLQVLSLGNNRIDNMMNIIYLRRFKCLRT 160
              L+ LV L +L L +N IS +++  +  L  LQ +++  N   ++  I+ L  F  L  
Sbjct: 1029 PSLENLVLLRELHLDDNSISTVEAFSSYWLPLLQNITISQN---SLTKIVPLFHFVSLEK 1085

Query: 161  LSLSRNPISEAED-YKMFICAY 181
            L +S N +S+ +   K F   Y
Sbjct: 1086 LDVSHNCLSDLKSAIKWFDACY 1107



 Score = 39.3 bits (90), Expect = 0.009
 Identities = 26/86 (30%), Positives = 42/86 (48%), Gaps = 1/86 (1%)

Query: 58  IDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLF 117
           +  L +  NL+ L L    +  +  L N   L ++D   N+IE IE  + L NL  + L 
Sbjct: 811 LSTLAECTNLQFLSLRRCGLTSLHSLSNCKKLKYIDAQENHIEAIE-CENLENLCVVLLN 869

Query: 118 NNRISKIDSLDALVKLQVLSLGNNRI 143
            N+++ +  LD    +Q L L  N+I
Sbjct: 870 KNQLTSLHGLDGCTNIQCLELSYNKI 895



 Score = 38.5 bits (88), Expect = 0.015
 Identities = 34/138 (24%), Positives = 61/138 (44%), Gaps = 8/138 (5%)

Query: 82   GLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNN 141
            GLE+L +L  L L  N +   +GL     +  L   +N ++ ++ ++    LQ+L L  N
Sbjct: 964  GLESLKNLQQLILDHNQLINTKGLCDTPTIVYLDCSHNHLTDVEGVENCGLLQILKLQGN 1023

Query: 142  RIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICAYLPDLMYLDYRRIDDHTKKLA 201
             +  + +   L     LR L L  N IS  E +  +   +LP L  +   +  +   K+ 
Sbjct: 1024 YLSELPS---LENLVLLRELHLDDNSISTVEAFSSY---WLPLLQNITISQ--NSLTKIV 1075

Query: 202  EAKHQYSIDELKHQENLM 219
               H  S+++L    N +
Sbjct: 1076 PLFHFVSLEKLDVSHNCL 1093



 Score = 35.8 bits (81), Expect = 0.098
 Identities = 22/67 (32%), Positives = 38/67 (56%), Gaps = 1/67 (1%)

Query: 58  IDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLF 117
           + +L   + L+ +    N IE IE  ENL +L  + L+ N + ++ GLD   N++ L L 
Sbjct: 833 LHSLSNCKKLKYIDAQENHIEAIE-CENLENLCVVLLNKNQLTSLHGLDGCTNIQCLELS 891

Query: 118 NNRISKI 124
            N+I++I
Sbjct: 892 YNKITRI 898



 Score = 29.6 bits (65), Expect = 7.0
 Identities = 35/149 (23%), Positives = 73/149 (48%), Gaps = 20/149 (13%)

Query: 213 KHQENL--MQAQLEDEQAQ-REELEKHKTAFVEHLNGSFL-----FDSMYAEDSEGNNLS 264
           +H+E +  +  Q+E+E+ + +++ EK K + ++  N + +     + +  A    G    
Sbjct: 249 QHEEYIRNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYG---- 304

Query: 265 YLPGVGELLETYKDKFVIICVNIFEYGLKQQEKRKTELDTFSECVREAIQENQEQGKRKI 324
             P + E +E+ K K         +   K++E RK  L+       E  ++ +E+ KR+ 
Sbjct: 305 --PIIKEQIESKKRKAQEWKEKEAKIRQKEEENRK-RLEEEQRIKEERKKQKEEERKRRE 361

Query: 325 AKFEEKHLSSLSAIREELE-LPNIEKMIL 352
            ++EEK     + +++E E L + EK+IL
Sbjct: 362 KEYEEKK----NIVKQEREQLISKEKIIL 386


>gi|120953243 leucine-rich repeats and IQ motif containing 1 isoform 2
            [Homo sapiens]
          Length = 1336

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 53/203 (26%), Positives = 98/203 (48%), Gaps = 9/203 (4%)

Query: 61   LWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNR 120
            L   +NL++L LD+N +   +GL +   +V+LD S N++  +EG++    L+ L L  N 
Sbjct: 965  LESLKNLQQLILDHNQLINTKGLCDTPTIVYLDCSHNHLTDVEGVENCGLLQILKLQGNY 1024

Query: 121  ISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICA 180
            +S++ SL+ LV L+ L L +N I + +          L+ +++S+N +++      F+  
Sbjct: 1025 LSELPSLENLVLLRELHLDDNSI-STVEAFSSYWLPLLQNITISQNSLTKIVPLFHFVSL 1083

Query: 181  YLPDLMYLDYRRIDDHTKKLAEAKHQYSIDELKHQENLMQAQLEDEQAQREELEKHKTAF 240
               + + + +  + D    +      YS+ EL    +L    L  E   R+ L K   A 
Sbjct: 1084 ---EKLDVSHNCLSDLKSAIKWFDACYSLHEL----SLTGNPLLQETNWRDSLLKVLPA- 1135

Query: 241  VEHLNGSFLFDSMYAEDSEGNNL 263
            +  LNG+ L  +  +   E N L
Sbjct: 1136 LRILNGNILNSNSESRTEEHNQL 1158



 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 39/142 (27%), Positives = 67/142 (47%), Gaps = 6/142 (4%)

Query: 43   KDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETI 102
            K++  L LD   ++    L     +  L   +N +  +EG+EN   L  L L  N +  +
Sbjct: 969  KNLQQLILDHNQLINTKGLCDTPTIVYLDCSHNHLTDVEGVENCGLLQILKLQGNYLSEL 1028

Query: 103  EGLDTLVNLEDLSLFNNRISKIDSLDA--LVKLQVLSLGNNRIDNMMNIIYLRRFKCLRT 160
              L+ LV L +L L +N IS +++  +  L  LQ +++  N   ++  I+ L  F  L  
Sbjct: 1029 PSLENLVLLRELHLDDNSISTVEAFSSYWLPLLQNITISQN---SLTKIVPLFHFVSLEK 1085

Query: 161  LSLSRNPISEAED-YKMFICAY 181
            L +S N +S+ +   K F   Y
Sbjct: 1086 LDVSHNCLSDLKSAIKWFDACY 1107



 Score = 39.3 bits (90), Expect = 0.009
 Identities = 26/86 (30%), Positives = 42/86 (48%), Gaps = 1/86 (1%)

Query: 58  IDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLF 117
           +  L +  NL+ L L    +  +  L N   L ++D   N+IE IE  + L NL  + L 
Sbjct: 811 LSTLAECTNLQFLSLRRCGLTSLHSLSNCKKLKYIDAQENHIEAIE-CENLENLCVVLLN 869

Query: 118 NNRISKIDSLDALVKLQVLSLGNNRI 143
            N+++ +  LD    +Q L L  N+I
Sbjct: 870 KNQLTSLHGLDGCTNIQCLELSYNKI 895



 Score = 38.5 bits (88), Expect = 0.015
 Identities = 34/138 (24%), Positives = 61/138 (44%), Gaps = 8/138 (5%)

Query: 82   GLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNN 141
            GLE+L +L  L L  N +   +GL     +  L   +N ++ ++ ++    LQ+L L  N
Sbjct: 964  GLESLKNLQQLILDHNQLINTKGLCDTPTIVYLDCSHNHLTDVEGVENCGLLQILKLQGN 1023

Query: 142  RIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICAYLPDLMYLDYRRIDDHTKKLA 201
             +  + +   L     LR L L  N IS  E +  +   +LP L  +   +  +   K+ 
Sbjct: 1024 YLSELPS---LENLVLLRELHLDDNSISTVEAFSSY---WLPLLQNITISQ--NSLTKIV 1075

Query: 202  EAKHQYSIDELKHQENLM 219
               H  S+++L    N +
Sbjct: 1076 PLFHFVSLEKLDVSHNCL 1093



 Score = 35.8 bits (81), Expect = 0.098
 Identities = 22/67 (32%), Positives = 38/67 (56%), Gaps = 1/67 (1%)

Query: 58  IDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLF 117
           + +L   + L+ +    N IE IE  ENL +L  + L+ N + ++ GLD   N++ L L 
Sbjct: 833 LHSLSNCKKLKYIDAQENHIEAIE-CENLENLCVVLLNKNQLTSLHGLDGCTNIQCLELS 891

Query: 118 NNRISKI 124
            N+I++I
Sbjct: 892 YNKITRI 898



 Score = 29.6 bits (65), Expect = 7.0
 Identities = 35/149 (23%), Positives = 73/149 (48%), Gaps = 20/149 (13%)

Query: 213 KHQENL--MQAQLEDEQAQ-REELEKHKTAFVEHLNGSFL-----FDSMYAEDSEGNNLS 264
           +H+E +  +  Q+E+E+ + +++ EK K + ++  N + +     + +  A    G    
Sbjct: 249 QHEEYIRNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYG---- 304

Query: 265 YLPGVGELLETYKDKFVIICVNIFEYGLKQQEKRKTELDTFSECVREAIQENQEQGKRKI 324
             P + E +E+ K K         +   K++E RK  L+       E  ++ +E+ KR+ 
Sbjct: 305 --PIIKEQIESKKRKAQEWKEKEAKIRQKEEENRK-RLEEEQRIKEERKKQKEEERKRRE 361

Query: 325 AKFEEKHLSSLSAIREELE-LPNIEKMIL 352
            ++EEK     + +++E E L + EK+IL
Sbjct: 362 KEYEEKK----NIVKQEREQLISKEKIIL 386


>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
           isoform 1 [Homo sapiens]
          Length = 1059

 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 45/142 (31%), Positives = 76/142 (53%), Gaps = 7/142 (4%)

Query: 54  NILRIDNLWQFENLRKLQLDNNIIEKIEGLENL-AHLVWLDLSFNNIETI--EGLDTLVN 110
           + ++  ++   ++LR+++L+NN +E I  L  + A++  L L+ N I  I  E L    +
Sbjct: 27  SFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQS 86

Query: 111 LEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISE 170
           LE L L +N IS++ +    ++L+ L L +NR+ +M    +      L  L L+RN IS 
Sbjct: 87  LETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRIS- 145

Query: 171 AEDYKMFICAYLPDLMYLDYRR 192
           A   KMF    LP L +L+  R
Sbjct: 146 AIPPKMF---KLPQLQHLELNR 164



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 41/114 (35%), Positives = 56/114 (49%), Gaps = 7/114 (6%)

Query: 62  WQFENLRKLQLD-NNIIEKIEG-LENLAHLVWLDLSFNNIETI--EGLDTLVNLEDLSLF 117
           W   N+  LQLD NN+ E  +G L  L  L  L LS N I  I  +  +    L +L L 
Sbjct: 200 WGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLT 259

Query: 118 NNRISKID--SLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPIS 169
            N +S++D  S   L  L  L +GNNR+  + +  + R    L+TL L  N IS
Sbjct: 260 FNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAF-RGLSSLKTLDLKNNEIS 312



 Score = 29.6 bits (65), Expect = 7.0
 Identities = 24/89 (26%), Positives = 39/89 (43%), Gaps = 24/89 (26%)

Query: 108 LVNLEDLSLFNNRIS--KIDSLDALVKLQVLSLGNNRIDNMMNI---------------- 149
           L ++    L +NR+S  K  S+  L  L+ + L NN ++ + N+                
Sbjct: 13  LFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNR 72

Query: 150 ------IYLRRFKCLRTLSLSRNPISEAE 172
                  +L+ F+ L TL LS N ISE +
Sbjct: 73  IVEILPEHLKEFQSLETLDLSSNNISELQ 101


>gi|61966709 leucine rich repeat containing 67 [Homo sapiens]
          Length = 228

 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 43/139 (30%), Positives = 68/139 (48%), Gaps = 5/139 (3%)

Query: 43  KDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETI 102
           K +  +    +NI  I++L   +NL  L L +N I +I  L    +L  L L  N I  I
Sbjct: 28  KKITHINFSDKNIDAIEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISCI 87

Query: 103 EGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRR-----FKC 157
           E L +L  LE L L  N I+ I+ L+ L +L+ L + N R+     +++  R      K 
Sbjct: 88  ENLRSLKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAKS 147

Query: 158 LRTLSLSRNPISEAEDYKM 176
           L  L++S N I +  D ++
Sbjct: 148 LCILNISNNNIDDITDLEL 166



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 44/126 (34%), Positives = 62/126 (49%), Gaps = 8/126 (6%)

Query: 41  LFKDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIE 100
           L K++  L L    I +I NL    NL  L L NN I  IE L +L  L  L L  N I 
Sbjct: 48  LCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISCIENLRSLKKLEKLYLGGNYIA 107

Query: 101 TIEGLDTLVNLEDLSLFNNRISKID-------SLDALVK-LQVLSLGNNRIDNMMNIIYL 152
            IEGL+ L  L +L + N R+   +       +L +L K L +L++ NN ID++ ++  L
Sbjct: 108 VIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAKSLCILNISNNNIDDITDLELL 167

Query: 153 RRFKCL 158
                L
Sbjct: 168 ENLNQL 173


>gi|62912472 leucine-rich repeat-containing G protein-coupled
           receptor 6 isoform 2 [Homo sapiens]
          Length = 915

 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 45/139 (32%), Positives = 69/139 (49%), Gaps = 9/139 (6%)

Query: 39  GILFKDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKI-----EGLENLAHLVWLD 93
           G+    +L LQ +    +  + LW+  +L+ L+LD N+I  +     EGL +L HL WLD
Sbjct: 60  GLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHL-WLD 118

Query: 94  LSFNNIETIEGLDTLVNLEDLSLFNNRISKID--SLDALVKLQVLSLGNNRIDNMMNIIY 151
            +      +  L+ L  L+ ++L  NRIS I   +   L  L VL L NNRI ++    +
Sbjct: 119 DNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSF 178

Query: 152 LRRFKCLRTLSLSRNPISE 170
                 L TL L+ N + E
Sbjct: 179 -EGLHNLETLDLNYNKLQE 196



 Score = 35.0 bits (79), Expect = 0.17
 Identities = 24/62 (38%), Positives = 32/62 (51%), Gaps = 2/62 (3%)

Query: 84  ENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKI--DSLDALVKLQVLSLGNN 141
           + L  L  L+LS N IE +  L     LE++ L +NRI +I  D+   L  LQ L L  N
Sbjct: 297 QQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWN 356

Query: 142 RI 143
            I
Sbjct: 357 AI 358


>gi|62912470 leucine-rich repeat-containing G protein-coupled
           receptor 6 isoform 1 [Homo sapiens]
          Length = 967

 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 45/139 (32%), Positives = 69/139 (49%), Gaps = 9/139 (6%)

Query: 39  GILFKDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKI-----EGLENLAHLVWLD 93
           G+    +L LQ +    +  + LW+  +L+ L+LD N+I  +     EGL +L HL WLD
Sbjct: 112 GLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHL-WLD 170

Query: 94  LSFNNIETIEGLDTLVNLEDLSLFNNRISKID--SLDALVKLQVLSLGNNRIDNMMNIIY 151
            +      +  L+ L  L+ ++L  NRIS I   +   L  L VL L NNRI ++    +
Sbjct: 171 DNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSF 230

Query: 152 LRRFKCLRTLSLSRNPISE 170
                 L TL L+ N + E
Sbjct: 231 -EGLHNLETLDLNYNKLQE 248



 Score = 35.0 bits (79), Expect = 0.17
 Identities = 24/62 (38%), Positives = 32/62 (51%), Gaps = 2/62 (3%)

Query: 84  ENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKI--DSLDALVKLQVLSLGNN 141
           + L  L  L+LS N IE +  L     LE++ L +NRI +I  D+   L  LQ L L  N
Sbjct: 349 QQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWN 408

Query: 142 RI 143
            I
Sbjct: 409 AI 410


>gi|239754500 PREDICTED: Leucine-rich repeat-containing protein
           ENSP00000371558 [Homo sapiens]
          Length = 336

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 45/156 (28%), Positives = 75/156 (48%), Gaps = 21/156 (13%)

Query: 44  DVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIE 103
           DV  L L  + +  + +L +F+ L+ L L +N +  I  L     L  L L+ N I  IE
Sbjct: 95  DVFELFLSKKELTEVIDLSRFKKLKYLWLHHNKLHGITFLTRNYCLTELYLNNNAIFEIE 154

Query: 104 GLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSL 163
           GL  L +L  L L +N ++ I   DA VK          +  M+N         L+ LSL
Sbjct: 155 GLHYLPSLHILLLHHNELTNI---DATVK---------ELKGMLN---------LKILSL 193

Query: 164 SRNPISEAEDYKMFICAYLPDLMYLDYRRIDDHTKK 199
            +NP+ +   Y+++I  +LP +  LD  ++ +  ++
Sbjct: 194 YQNPLCQYNLYRLYIIYHLPGVELLDRNQVTEKERR 229



 Score = 35.8 bits (81), Expect = 0.098
 Identities = 31/99 (31%), Positives = 45/99 (45%), Gaps = 17/99 (17%)

Query: 38  EGILFKDVLSLQLDFRNILRIDNLWQFEN-------------LRKLQLDNNIIEKIEGLE 84
           E  L K  L+  +D     ++  LW   N             L +L L+NN I +IEGL 
Sbjct: 98  ELFLSKKELTEVIDLSRFKKLKYLWLHHNKLHGITFLTRNYCLTELYLNNNAIFEIEGLH 157

Query: 85  NLAHLVWLDLSFNNI----ETIEGLDTLVNLEDLSLFNN 119
            L  L  L L  N +     T++ L  ++NL+ LSL+ N
Sbjct: 158 YLPSLHILLLHHNELTNIDATVKELKGMLNLKILSLYQN 196


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.136    0.382 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,401,084
Number of Sequences: 37866
Number of extensions: 739900
Number of successful extensions: 4414
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 69
Number of HSP's successfully gapped in prelim test: 346
Number of HSP's that attempted gapping in prelim test: 3699
Number of HSP's gapped (non-prelim): 892
length of query: 523
length of database: 18,247,518
effective HSP length: 107
effective length of query: 416
effective length of database: 14,195,856
effective search space: 5905476096
effective search space used: 5905476096
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.