Search of human proteins with 194018474

Search of human proteins with 194018474

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|194018474 leucine rich repeat containing 52 [Homo sapiens]
         (313 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|194018474 leucine rich repeat containing 52 [Homo sapiens]         641   0.0  
gi|52353306 leucine rich repeat containing 55 [Homo sapiens]          142   5e-34
gi|239752702 PREDICTED: leucine rich repeat containing 38, parti...   120   2e-27
gi|239747236 PREDICTED: leucine rich repeat containing 38 [Homo ...   117   1e-26
gi|239741057 PREDICTED: leucine rich repeat containing 38 [Homo ...   117   1e-26
gi|61966761 leucine rich repeat containing 26 [Homo sapiens]           96   4e-20
gi|188528675 slit homolog 1 [Homo sapiens]                             92   6e-19
gi|10190722 leucine-rich repeats and transmembrane domains 1 [Ho...    92   6e-19
gi|84781739 leucine-rich repeats and transmembrane domains 2 [Ho...    89   5e-18
gi|11321571 slit homolog 3 [Homo sapiens]                              87   2e-17
gi|4759146 slit homolog 2 [Homo sapiens]                               86   6e-17
gi|198041768 synleurin [Homo sapiens]                                  86   6e-17
gi|229089140 leucine rich repeat containing 24 [Homo sapiens]          84   2e-16
gi|126517478 peroxidasin homolog-like [Homo sapiens]                   83   3e-16
gi|122937309 leucine rich repeat containing 4B [Homo sapiens]          82   5e-16
gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]       80   3e-15
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom...    78   9e-15
gi|51317373 netrin-G1 ligand [Homo sapiens]                            78   1e-14
gi|88702793 slit-like 2 [Homo sapiens]                                 76   3e-14
gi|139948432 adlican [Homo sapiens]                                    75   6e-14
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s...    75   6e-14
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa...    75   6e-14
gi|225579152 insulin-like growth factor binding protein, acid la...    75   7e-14
gi|4826772 insulin-like growth factor binding protein, acid labi...    75   7e-14
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo...    74   2e-13
gi|194306623 immunoglobulin superfamily containing leucine-rich ...    74   2e-13
gi|194306621 immunoglobulin superfamily containing leucine-rich ...    74   2e-13
gi|39930401 immunoglobulin superfamily containing leucine-rich r...    74   2e-13
gi|194306618 immunoglobulin superfamily containing leucine-rich ...    74   2e-13
gi|31542244 leucine rich repeat and fibronectin type III domain ...    73   3e-13

>gi|194018474 leucine rich repeat containing 52 [Homo sapiens]
          Length = 313

 Score =  641 bits (1654), Expect = 0.0
 Identities = 313/313 (100%), Positives = 313/313 (100%)

Query: 1   MSLASGPGPGWLLFSFGMGLVSGSKCPNNCLCQAQEVICTGKQLTEYPLDIPLNTRRLFL 60
           MSLASGPGPGWLLFSFGMGLVSGSKCPNNCLCQAQEVICTGKQLTEYPLDIPLNTRRLFL
Sbjct: 1   MSLASGPGPGWLLFSFGMGLVSGSKCPNNCLCQAQEVICTGKQLTEYPLDIPLNTRRLFL 60

Query: 61  NENRITSLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFT 120
           NENRITSLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFT
Sbjct: 61  NENRITSLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFT 120

Query: 121 FSVLSNLVQLNIANNPHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLF 180
           FSVLSNLVQLNIANNPHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLF
Sbjct: 121 FSVLSNLVQLNIANNPHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLF 180

Query: 181 LSGNPWKCNCSFLDFAIFLIVFHMDPSDDLNATCVEPTELTGWPITRVGNPLRYMCITHL 240
           LSGNPWKCNCSFLDFAIFLIVFHMDPSDDLNATCVEPTELTGWPITRVGNPLRYMCITHL
Sbjct: 181 LSGNPWKCNCSFLDFAIFLIVFHMDPSDDLNATCVEPTELTGWPITRVGNPLRYMCITHL 240

Query: 241 DHKDYIFLLLIGFCIFAAGTVAAWLTGVCAVLYQNTRHKSSEEDEDEAGTRVEVSRRIFQ 300
           DHKDYIFLLLIGFCIFAAGTVAAWLTGVCAVLYQNTRHKSSEEDEDEAGTRVEVSRRIFQ
Sbjct: 241 DHKDYIFLLLIGFCIFAAGTVAAWLTGVCAVLYQNTRHKSSEEDEDEAGTRVEVSRRIFQ 300

Query: 301 TQTSSVQEFPQLI 313
           TQTSSVQEFPQLI
Sbjct: 301 TQTSSVQEFPQLI 313


>gi|52353306 leucine rich repeat containing 55 [Homo sapiens]
          Length = 341

 Score =  142 bits (357), Expect = 5e-34
 Identities = 95/287 (33%), Positives = 138/287 (48%), Gaps = 10/287 (3%)

Query: 7   PGPGWLLFSF--GMGLV---SGSKCPNNCLCQAQEVICTGKQLTEYPLDIPLNTRRLFLN 61
           P P  LL S     GL+   +G+ CP  C C+ Q V C+ ++L   P D+P++TR L L 
Sbjct: 57  PHPAMLLISLLLAAGLMHSDAGTSCPVLCTCRNQVVDCSSQRLFSVPPDLPMDTRNLSLA 116

Query: 62  ENRITSLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFTF 121
            NRIT++P  +L    +L  LD  NN + E+    F+   +L +LDLS NN + +    F
Sbjct: 117 HNRITAVPPGYLTCYMELQVLDLHNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMF 176

Query: 122 SVLSNLVQLNIANNPHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFL 181
                LV +++++NP L  +H   F     LR LDL   GL  L   AL  L  L TL +
Sbjct: 177 QEAHGLVHIDLSHNPWLRRVHPQAFQGLMQLRDLDLSYGGLAFLSLEALEGLPGLVTLQI 236

Query: 182 SGNPWKCNCSFLDFAIFLIV-FHMDPSDDLNATCVEPTELTGWPITRVGNPLRYMCITHL 240
            GNPW C C+      +L        +D   A C  P E+ G P+  +       C   L
Sbjct: 237 GGNPWVCGCTMEPLLKWLRNRIQRCTADSQLAECRGPPEVEGAPLFSLTEESFKACHLTL 296

Query: 241 DHKDYIFLLLIGFCIFAAGTVAAWLTGVCAVLYQNTRHKSSEEDEDE 287
              DY+F+  +GF +  A     +L G+ A    N  H+ S+  E+E
Sbjct: 297 TLDDYLFIAFVGFVVSIASVATNFLLGITA----NCCHRWSKASEEE 339


>gi|239752702 PREDICTED: leucine rich repeat containing 38, partial
           [Homo sapiens]
          Length = 254

 Score =  120 bits (301), Expect = 2e-27
 Identities = 79/250 (31%), Positives = 115/250 (46%), Gaps = 2/250 (0%)

Query: 39  CTGKQLTEYPLDIPLNTRRLFLNENRITSLPAMHLGLLSDLVYLDCQNNRIREVMDYTFI 98
           C  + L   P   PL+ R+L +  NRI  +P        DLVYLD +NN +R + + TF 
Sbjct: 2   CRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFS 61

Query: 99  GVFKLIYLDLSSNNLTSISPFTFSVLSNLVQLNIANNPHLLSLHKFTFANTTSLRYLDLR 158
           G  KL++LDLS NNLT +    F     LV+L++ANN +L+ +H+  F    SL+ L+L 
Sbjct: 62  GSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANN-NLVGVHEDAFETLESLQVLELN 120

Query: 159 NTGLQTLDSAALYHLTTLETLFLSGNPWKCNCSFLD-FAIFLIVFHMDPSDDLNATCVEP 217
           +  L++L  AAL  L  L +L L GNPW C+C F   F+         P       C  P
Sbjct: 121 DNNLRSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLP 180

Query: 218 TELTGWPITRVGNPLRYMCITHLDHKDYIFLLLIGFCIFAAGTVAAWLTGVCAVLYQNTR 277
            E     +  +       C   L   D   ++  G  +  A  ++++         Q   
Sbjct: 181 MESRRISLRELSEASFSECRFSLSLTDLCIIIFSGVAVSIAAIISSFFLATVVQCLQRCA 240

Query: 278 HKSSEEDEDE 287
                EDEDE
Sbjct: 241 PNKDAEDEDE 250


>gi|239747236 PREDICTED: leucine rich repeat containing 38 [Homo
           sapiens]
          Length = 408

 Score =  117 bits (294), Expect = 1e-26
 Identities = 78/245 (31%), Positives = 113/245 (46%), Gaps = 2/245 (0%)

Query: 44  LTEYPLDIPLNTRRLFLNENRITSLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKL 103
           L   P   PL+ R+L +  NRI  +P        DLVYLD +NN +R + + TF G  KL
Sbjct: 161 LPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKL 220

Query: 104 IYLDLSSNNLTSISPFTFSVLSNLVQLNIANNPHLLSLHKFTFANTTSLRYLDLRNTGLQ 163
           ++LDLS NNLT +    F     LV+L++ANN +L+ +H+  F    SL+ L+L +  L+
Sbjct: 221 VFLDLSYNNLTQLGAGAFRSAGRLVKLSLANN-NLVGVHEDAFETLESLQVLELNDNNLR 279

Query: 164 TLDSAALYHLTTLETLFLSGNPWKCNCSFLD-FAIFLIVFHMDPSDDLNATCVEPTELTG 222
           +L  AAL  L  L +L L GNPW C+C F   F+         P       C  P E   
Sbjct: 280 SLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESRR 339

Query: 223 WPITRVGNPLRYMCITHLDHKDYIFLLLIGFCIFAAGTVAAWLTGVCAVLYQNTRHKSSE 282
             +  +       C   L   D   ++  G  +  A  ++++         Q        
Sbjct: 340 ISLRELSEASFSECRFSLSLTDLCIIIFSGVAVSIAAIISSFFLATVVQCLQRCAPNKDA 399

Query: 283 EDEDE 287
           EDEDE
Sbjct: 400 EDEDE 404


>gi|239741057 PREDICTED: leucine rich repeat containing 38 [Homo
           sapiens]
          Length = 408

 Score =  117 bits (294), Expect = 1e-26
 Identities = 78/245 (31%), Positives = 113/245 (46%), Gaps = 2/245 (0%)

Query: 44  LTEYPLDIPLNTRRLFLNENRITSLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKL 103
           L   P   PL+ R+L +  NRI  +P        DLVYLD +NN +R + + TF G  KL
Sbjct: 161 LPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKL 220

Query: 104 IYLDLSSNNLTSISPFTFSVLSNLVQLNIANNPHLLSLHKFTFANTTSLRYLDLRNTGLQ 163
           ++LDLS NNLT +    F     LV+L++ANN +L+ +H+  F    SL+ L+L +  L+
Sbjct: 221 VFLDLSYNNLTQLGAGAFRSAGRLVKLSLANN-NLVGVHEDAFETLESLQVLELNDNNLR 279

Query: 164 TLDSAALYHLTTLETLFLSGNPWKCNCSFLD-FAIFLIVFHMDPSDDLNATCVEPTELTG 222
           +L  AAL  L  L +L L GNPW C+C F   F+         P       C  P E   
Sbjct: 280 SLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESRR 339

Query: 223 WPITRVGNPLRYMCITHLDHKDYIFLLLIGFCIFAAGTVAAWLTGVCAVLYQNTRHKSSE 282
             +  +       C   L   D   ++  G  +  A  ++++         Q        
Sbjct: 340 ISLRELSEASFSECRFSLSLTDLCIIIFSGVAVSIAAIISSFFLATVVQCLQRCAPNKDA 399

Query: 283 EDEDE 287
           EDEDE
Sbjct: 400 EDEDE 404


>gi|61966761 leucine rich repeat containing 26 [Homo sapiens]
          Length = 334

 Score = 95.9 bits (237), Expect = 4e-20
 Identities = 77/269 (28%), Positives = 107/269 (39%), Gaps = 5/269 (1%)

Query: 3   LASGPGPGWLLFSFGM---GLVSGSKCPNNCLCQAQEVI-CTGKQLTEYPLDIPLNTRRL 58
           L   P P W   S      G +    CP  C C    +  C+   L   P  + L  R L
Sbjct: 17  LLLSPWPVWAQVSATASPSGSLGAPDCPEVCTCVPGGLASCSALSLPAVPPGLSLRLRAL 76

Query: 59  FLNENRITSLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISP 118
            L+ NR+ +LP         L  LD + N +  V    F G+  L  LDLS+N L +++P
Sbjct: 77  LLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAP 136

Query: 119 FTFSVLSNLVQLNIANNPHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLTTLET 178
            TF+ L  L  L++A N  L  L          LR L L++  L  L    L  L  L+ 
Sbjct: 137 GTFAPLRALRNLSLAGN-RLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDA 195

Query: 179 LFLSGNPWKCNCSFLDFAIFLIVFHMDPSDDLNATCVEPTELTGWPITRVGNPLRYMCIT 238
           L L GNPW C C+      +L    +  S+     CV P  LT  P+T   +     C  
Sbjct: 196 LHLRGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVWPGRLTLSPLTAFSDAAFSHCAQ 255

Query: 239 HLDHKDYIFLLLIGFCIFAAGTVAAWLTG 267
            L  +D   +  +G   F     +    G
Sbjct: 256 PLALRDLAVVYTLGPASFLVSLASCLALG 284


>gi|188528675 slit homolog 1 [Homo sapiens]
          Length = 1534

 Score = 92.0 bits (227), Expect = 6e-19
 Identities = 57/166 (34%), Positives = 85/166 (51%), Gaps = 2/166 (1%)

Query: 26  CPNNCLCQAQEVICTGKQLTEYPLDIPLNTRRLFLNENRITSLPAMHL-GLLSDLVYLDC 84
           CP+ C C+A  V C+  +LT+ P  IP +T  L LN N I+ L A  +   L+ L  ++ 
Sbjct: 513 CPHKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINL 572

Query: 85  QNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFTFSVLSNLVQLNIANNPHLLSLHKF 144
            NN++ E+ D  F G   +  L L++N L SI    F  L  L  L + NN  +  +H  
Sbjct: 573 SNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNN-RISCIHND 631

Query: 145 TFANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFLSGNPWKCNC 190
           +F    ++R L L +  + T+   A   L +L TL L  NP+ CNC
Sbjct: 632 SFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNC 677



 Score = 82.0 bits (201), Expect = 6e-16
 Identities = 60/208 (28%), Positives = 89/208 (42%), Gaps = 4/208 (1%)

Query: 21  VSGSKCPNNCLCQAQEVICTGKQLTEYPLDIPLNTRRLFLNENRITSLPAMHLGLLSDLV 80
           +S   CP  C C    V C GK LT  P ++P     + L  N I S+P         L 
Sbjct: 277 LSSGSCPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLR 336

Query: 81  YLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFTFSVLSNLVQLNIANNPHLLS 140
            +D  NN+I E+    F G+  L  L L  N +T +    F  L  L QL + N   +  
Sbjct: 337 RIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTL-QLLLLNANKINC 395

Query: 141 LHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFLSGNPWKCNCSFLDFAIFLI 200
           +    F +  +L  L L +  +Q+L       L  ++TL L+ NP+ C+C+    A FL 
Sbjct: 396 IRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFL- 454

Query: 201 VFHMDPSDDLNATCVEPTELTGWPITRV 228
               +P +   A C  P  L    I ++
Sbjct: 455 --RTNPIETSGARCASPRRLANKRIGQI 480



 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 55/204 (26%), Positives = 85/204 (41%), Gaps = 29/204 (14%)

Query: 19  GLVSGSKCPNNCLCQAQEVICTGKQLTEYPLDIPLNTRRLFLNENRITSLPAMHLGLLSD 78
           G +   +CP  C C    V C+ K L   P  IP N   L+L+ N+ T +P    G LS 
Sbjct: 727 GCLPRPQCPQECACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVP----GQLST 782

Query: 79  LVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFTFSVLSNLVQLNIANNPHL 138
             YL                       +DLS+N ++S+S  +F+ +S L  L ++ N  L
Sbjct: 783 FKYLQL---------------------VDLSNNKISSLSNSSFTNMSQLTTLILSYNA-L 820

Query: 139 LSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFLSGNPWKCNCSFLDFAIF 198
             +    F    SLR L L    + TL       +T+L  L +  NP  C+C     + +
Sbjct: 821 QCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSW 880

Query: 199 LIVFHMDPSDDLNATCVEPTELTG 222
           +   + +P     A C  P ++ G
Sbjct: 881 VKTGYKEPG---IARCAGPQDMEG 901



 Score = 69.3 bits (168), Expect = 4e-12
 Identities = 52/174 (29%), Positives = 73/174 (41%), Gaps = 1/174 (0%)

Query: 11  WLLFSFGMGLVSGSKCPNNCLCQAQEVICTGKQLTEYPLDIPLNTRRLFLNENRITSLPA 70
           WLL       +  S CP  C C    V C G  L   P +IP NT RL LN N IT +  
Sbjct: 19  WLLLWAAAWRLGASACPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHK 78

Query: 71  MHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFTFSVLSNLVQL 130
                L  L  L    N+I  V    F  + +L  L L+ N L  +    F     L +L
Sbjct: 79  NDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRL 138

Query: 131 NIANNPHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFLSGN 184
           +++ N  + ++ +  F   T L+ L L    +  ++  A   L  LE L L+ N
Sbjct: 139 DLSENA-IQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNN 191



 Score = 35.4 bits (80), Expect = 0.066
 Identities = 24/86 (27%), Positives = 41/86 (47%)

Query: 57  RLFLNENRITSLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSI 116
           RL L+EN I ++P       +DL  L    N+I  + +  F  +  L  L L++NN+T+I
Sbjct: 137 RLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTI 196

Query: 117 SPFTFSVLSNLVQLNIANNPHLLSLH 142
              +F+ +  L    + +N      H
Sbjct: 197 PVSSFNHMPKLRTFRLHSNHLFCDCH 222


>gi|10190722 leucine-rich repeats and transmembrane domains 1 [Homo
           sapiens]
          Length = 345

 Score = 92.0 bits (227), Expect = 6e-19
 Identities = 66/215 (30%), Positives = 100/215 (46%), Gaps = 7/215 (3%)

Query: 26  CPNNCLCQAQE--VICTGKQLTEYPLDIPLNTRRLFLNENRITSLPAMHLGLLSDLVYLD 83
           CP+ C CQ+    V C+ + L E P  +P  TR L L +N+I  LPA     +  L+ L+
Sbjct: 21  CPDKCYCQSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAFRSVPWLMTLN 80

Query: 84  CQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFTFSVLSNLVQLNIANN--PHLLSL 141
             NN +  +    F G+  L  L+L+ N+L S+    F  L  L +L++++N   HL + 
Sbjct: 81  LSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLSSNNISHLPTS 140

Query: 142 HKFTFANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFLSGNPWKCNCSFLDFAIFLIV 201
              T+ N T    L ++   LQ LD A L  + ++  L L  N WKCNC  L   ++L  
Sbjct: 141 LGETWENLT---ILAVQQNQLQQLDRALLESMPSVRLLLLKDNLWKCNCHLLGLKLWLEK 197

Query: 202 FHMDPSDDLNATCVEPTELTGWPITRVGNPLRYMC 236
           F           C  P    G  + R+ + L   C
Sbjct: 198 FVYKGGLTDGIICESPDTWKGKDLLRIPHELYQPC 232


>gi|84781739 leucine-rich repeats and transmembrane domains 2 [Homo
           sapiens]
          Length = 370

 Score = 89.0 bits (219), Expect = 5e-18
 Identities = 62/199 (31%), Positives = 93/199 (46%), Gaps = 3/199 (1%)

Query: 26  CPNNCLCQAQ--EVICTGKQLTEYPLDIPLNTRRLFLNENRITSLPAMHLGLLSDLVYLD 83
           CP +C C ++  EV C+G  LT  P D+P  TR L L  N++++LP+     LS L  LD
Sbjct: 39  CPFSCKCDSRSLEVDCSGLGLTTVPPDVPAATRTLLLLNNKLSALPSWAFANLSSLQRLD 98

Query: 84  CQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFTFSVLSNLVQLNIANNPHLLSLHK 143
             NN +  +    F  +  L  L L +N++ ++          L  L+++ N  L  L  
Sbjct: 99  LSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSIN-GLAQLPP 157

Query: 144 FTFANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFLSGNPWKCNCSFLDFAIFLIVFH 203
             F    +LR L LR+  LQ LD      L  L+ L +  NPW+C+C+  +F  ++  F 
Sbjct: 158 GLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDNPWECDCNLREFKHWMEWFS 217

Query: 204 MDPSDDLNATCVEPTELTG 222
                     C  P EL G
Sbjct: 218 YRGGRLDQLACTLPKELRG 236


>gi|11321571 slit homolog 3 [Homo sapiens]
          Length = 1523

 Score = 87.0 bits (214), Expect = 2e-17
 Identities = 62/218 (28%), Positives = 100/218 (45%), Gaps = 5/218 (2%)

Query: 26  CPNNCLCQAQEVICTGKQLTEYPLDIPLNTRRLFLNENRITSLPAMHLGLLSDLVYLDCQ 85
           CP+ C C    V C GK L E P ++P     + L +N I ++PA        L  +D  
Sbjct: 280 CPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDIS 339

Query: 86  NNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFTFSVLSNLVQLNIANNPHLLSLHKFT 145
            N+I ++    F G+  L  L L  N +T I+   F  L +L QL + N   +  L   T
Sbjct: 340 KNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSL-QLLLLNANKINCLRVNT 398

Query: 146 FANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFLSGNPWKCNCSFLDFAIFLIVFHMD 205
           F +  +L  L L +  LQT+       L +++TL L+ NP+ C+C     A +L     +
Sbjct: 399 FQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYL---QDN 455

Query: 206 PSDDLNATCVEPTELTGWPITRVGNPLRYMCITHLDHK 243
           P +   A C  P  L    I+++ +  ++ C    D++
Sbjct: 456 PIETSGARCSSPRRLANKRISQIKSK-KFRCSGSEDYR 492



 Score = 80.9 bits (198), Expect = 1e-15
 Identities = 52/166 (31%), Positives = 83/166 (50%), Gaps = 2/166 (1%)

Query: 26  CPNNCLCQAQEVICTGKQLTEYPLDIPLNTRRLFLNENRITSLPAMHL-GLLSDLVYLDC 84
           CP  C C+   V C+ ++L   P  +P     L LN+N ++ L A  +   L +L  ++ 
Sbjct: 505 CPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINL 564

Query: 85  QNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFTFSVLSNLVQLNIANNPHLLSLHKF 144
            NN+I+EV +  F G   +  L L+ N L ++    F  LS L  L + +N  +  +   
Sbjct: 565 SNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNL-IGCVSND 623

Query: 145 TFANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFLSGNPWKCNC 190
           TFA  +S+R L L +  + T+   A   L +L T+ L  NP+ CNC
Sbjct: 624 TFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNC 669



 Score = 71.2 bits (173), Expect = 1e-12
 Identities = 46/159 (28%), Positives = 71/159 (44%), Gaps = 1/159 (0%)

Query: 26  CPNNCLCQAQEVICTGKQLTEYPLDIPLNTRRLFLNENRITSLPAMHLGLLSDLVYLDCQ 85
           CP  C C A  V C G  L   P  IP N  RL L+ N IT +  M    L +L  L  +
Sbjct: 34  CPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLE 93

Query: 86  NNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFTFSVLSNLVQLNIANNPHLLSLHKFT 145
           +N++  +    F  + +L  L L+ N L  +    F     L +L+++ N  +  + +  
Sbjct: 94  DNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSEN-QIQGIPRKA 152

Query: 146 FANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFLSGN 184
           F   T ++ L L N  +  ++  A   L  LE L L+ N
Sbjct: 153 FRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNN 191



 Score = 70.1 bits (170), Expect = 2e-12
 Identities = 49/167 (29%), Positives = 68/167 (40%), Gaps = 26/167 (15%)

Query: 25  KCPNNCLCQAQEVICTGKQLTEYPLDIPLNTRRLFLNENRITSLPAMHLGLLSDLVYLDC 84
           +CP  C C    V C+ K L   P  +P +   L+L  N +T++P   L  L  L  +D 
Sbjct: 724 RCPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVP-RELSALRHLTLIDL 782

Query: 85  QNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFTFSVLSNLVQLNIANNPHLLSLHKF 144
            NN I  + +YTF  +  L  L LS N L  I    F+ L                    
Sbjct: 783 SNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGL-------------------- 822

Query: 145 TFANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFLSGNPWKCNCS 191
                 SLR L L    + ++   +   LT+L  L L  NP  C+CS
Sbjct: 823 -----RSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCS 864



 Score = 37.4 bits (85), Expect = 0.017
 Identities = 23/79 (29%), Positives = 41/79 (51%)

Query: 57  RLFLNENRITSLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSI 116
           RL L+EN+I  +P      ++D+  L   NN I  + D  F  +  L  L L++NN++ I
Sbjct: 137 RLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRI 196

Query: 117 SPFTFSVLSNLVQLNIANN 135
              +F+ +  +  L + +N
Sbjct: 197 LVTSFNHMPKIRTLRLHSN 215


>gi|4759146 slit homolog 2 [Homo sapiens]
          Length = 1529

 Score = 85.5 bits (210), Expect = 6e-17
 Identities = 60/203 (29%), Positives = 89/203 (43%), Gaps = 4/203 (1%)

Query: 26  CPNNCLCQAQEVICTGKQLTEYPLDIPLNTRRLFLNENRITSLPAMHLGLLSDLVYLDCQ 85
           CP  C C    V C GK LTE P ++P     + L +N I  +P         L  +D  
Sbjct: 273 CPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLS 332

Query: 86  NNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFTFSVLSNLVQLNIANNPHLLSLHKFT 145
           NN+I E+    F G+  L  L L  N +T +    F  L +L QL + N   +  L    
Sbjct: 333 NNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSL-QLLLLNANKINCLRVDA 391

Query: 146 FANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFLSGNPWKCNCSFLDFAIFLIVFHMD 205
           F +  +L  L L +  LQT+       L  ++T+ L+ NP+ C+C     A +L   H +
Sbjct: 392 FQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYL---HTN 448

Query: 206 PSDDLNATCVEPTELTGWPITRV 228
           P +   A C  P  L    I ++
Sbjct: 449 PIETSGARCTSPRRLANKRIGQI 471



 Score = 81.3 bits (199), Expect = 1e-15
 Identities = 69/263 (26%), Positives = 96/263 (36%), Gaps = 36/263 (13%)

Query: 8   GPGWLLFSFGMGLV-------SGSKCPNNCLCQAQEVICTGKQLTEYPLDIPLNTRRLFL 60
           G GW + S  +GLV       +   CP  C C    V C G  L   P +IP NT RL L
Sbjct: 3   GVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDL 62

Query: 61  NENRITSLPAMHLGLLSDLVYLDCQNNRIREV------------------------MDYT 96
           N N IT +       L  L  L    N+I  +                         +  
Sbjct: 63  NGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELL 122

Query: 97  FIGVFKLIYLDLSSNNLTSISPFTFSVLSNLVQLNIANNPHLLSLHKFTFANTTSLRYLD 156
           F+G  KL  LDLS N + +I    F    ++  L +  N  +  +    F     L  L 
Sbjct: 123 FLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYN-QISCIEDGAFRALRDLEVLT 181

Query: 157 LRNTGLQTLDSAALYHLTTLETLFLSGNPWKCNCSFLDFAIFLIVFHMDPSDDLNATCVE 216
           L N  +  L  A+  H+  L T  L  N   C+C     + +L      P   L   C+ 
Sbjct: 182 LNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWL---RQRPRVGLYTQCMG 238

Query: 217 PTELTGWPITRVGNPLRYMCITH 239
           P+ L G  +  V     ++C  H
Sbjct: 239 PSHLRGHNVAEV-QKREFVCSGH 260



 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 51/166 (30%), Positives = 81/166 (48%), Gaps = 2/166 (1%)

Query: 26  CPNNCLCQAQEVICTGKQLTEYPLDIPLNTRRLFLNENRITSLPAMHL-GLLSDLVYLDC 84
           CP  C C+   V C+ ++L + P  IP  T  L LN N  T L A  +   L  L  ++ 
Sbjct: 506 CPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINF 565

Query: 85  QNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFTFSVLSNLVQLNIANNPHLLSLHKF 144
            NN+I ++ +  F G   +  + L+SN L ++    F  L +L  L + +N  +  +   
Sbjct: 566 SNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSN-RITCVGND 624

Query: 145 TFANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFLSGNPWKCNC 190
           +F   +S+R L L +  + T+   A   L +L TL L  NP+ CNC
Sbjct: 625 SFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNC 670



 Score = 70.9 bits (172), Expect = 1e-12
 Identities = 54/197 (27%), Positives = 80/197 (40%), Gaps = 29/197 (14%)

Query: 24  SKCPNNCLCQAQEVICTGKQLTEYPLDIPLNTRRLFLNENRITSLPAMHLGLLSDLVYLD 83
           S+CP  C C    V C+ K L   P  IP +   L+L+ N+ T +P   L     L  +D
Sbjct: 725 SRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPK-ELSNYKHLTLID 783

Query: 84  CQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFTFSVLSNLVQLNIANNPHLLSLHK 143
             NNRI  + + +F  + +L+ L LS N L  I P TF  L                   
Sbjct: 784 LSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLK------------------ 825

Query: 144 FTFANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFLSGNPWKCNCSFLDFAIFLIVFH 203
                  SLR L L    +  +   A   L+ L  L +  NP  C+C+    + ++   +
Sbjct: 826 -------SLRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEY 878

Query: 204 MDPSDDLNATCVEPTEL 220
            +P     A C  P E+
Sbjct: 879 KEPG---IARCAGPGEM 892


>gi|198041768 synleurin [Homo sapiens]
          Length = 622

 Score = 85.5 bits (210), Expect = 6e-17
 Identities = 66/200 (33%), Positives = 100/200 (50%), Gaps = 16/200 (8%)

Query: 44  LTEYP---LDIPLNTRRLFLNENRITSLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGV 100
           LT+ P    ++  + RRL L+ N I ++       L++L YL  +N+RIR V    F G+
Sbjct: 216 LTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGI 275

Query: 101 FKLIYLDLSSNNLTSISPFTFSVLSNLVQLNIANNPHLLSLHKFTFANT-TSLRYLDLRN 159
             L +L LS N+L +++  TFS+L NL+ L +  N  ++S+   TF N   SL+ L+L  
Sbjct: 276 NNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRN-RIISIDNDTFENMGASLKILNLSF 334

Query: 160 TGLQTLDSAALYHLTTLETLFLSGNPWKCNCSFLDFAIFLIVFHMDPSDDLNATCVEPTE 219
             L  L    L  L++L  L  + NPW+CNC  L    +L       +  LN  C  P  
Sbjct: 335 NNLTALHPRVLKPLSSLIHLQANSNPWECNCKLLGLRDWL----ASSAITLNIYCQNPPS 390

Query: 220 LTGWPITRVGNPLRYMCITH 239
           +        G  LRY+ IT+
Sbjct: 391 MR-------GRALRYINITN 403



 Score = 66.2 bits (160), Expect = 3e-11
 Identities = 47/135 (34%), Positives = 70/135 (51%), Gaps = 7/135 (5%)

Query: 53  LNTRRLFLNENRITSLPAMHLGLLSDLV---YLDCQNNRIREVMDYTFIGVFKLIYLDLS 109
           LN R L+L  N+++ +P    G+ +DLV   YL+ Q NR+  +   TF+G+  L  LDLS
Sbjct: 132 LNLRNLYLQYNQVSFVPR---GVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLS 188

Query: 110 SNNLTSISPFTFSVLSNLVQLNIANNPHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAA 169
           +NN+  IS   F  L NL  L + +N +L  +    F    SLR L L +  ++ +   A
Sbjct: 189 NNNILRISESGFQHLENLACLYLGSN-NLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFA 247

Query: 170 LYHLTTLETLFLSGN 184
              L  LE L L  +
Sbjct: 248 FKGLANLEYLLLKNS 262



 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 46/160 (28%), Positives = 74/160 (46%), Gaps = 2/160 (1%)

Query: 26  CPNNC-LCQAQEVICTGKQLTEYPLDIPLNTRRLFLNENRITSLPAMHLGLLSDLVYLDC 84
           C + C LC  +++ C    L+  P + P +T  L+L  N I+ +    L  L  LV L  
Sbjct: 32  CSSVCQLCTGRQINCRNLGLSSIPKNFPESTVFLYLTGNNISYINESELTGLHSLVALYL 91

Query: 85  QNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFTFSVLSNLVQLNIANNPHLLSLHKF 144
            N+ I  V    F+ +  L +L L++N +  + P  F  L NL  L +  N  +  + + 
Sbjct: 92  DNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYN-QVSFVPRG 150

Query: 145 TFANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFLSGN 184
            F +  S++YL+L+   L  L S     +  L  L LS N
Sbjct: 151 VFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNN 190


>gi|229089140 leucine rich repeat containing 24 [Homo sapiens]
          Length = 513

 Score = 83.6 bits (205), Expect = 2e-16
 Identities = 61/190 (32%), Positives = 86/190 (45%), Gaps = 25/190 (13%)

Query: 26  CPNNCLCQAQEVICTGKQLTEYPLDIPLNTRRLFLNENRI-------------------- 65
           CP  C C +  V C   +L   PL IP  T+ LFL +N I                    
Sbjct: 23  CPAACRCYSATVECGALRLRVVPLGIPPGTQTLFLQDNNIARLEPGALAPLAALRRLYLH 82

Query: 66  -TSLPAMHLGLL---SDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFTF 121
             SL A+  G       L+ L   +NR+R +    F+G+ +L  L L+ N L  +  FTF
Sbjct: 83  NNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLARLLDFTF 142

Query: 122 SVLSNLVQLNIANNPHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFL 181
             L  L +L++  N   L L     A  +SL  LDL    L T+   AL  L +L+ L L
Sbjct: 143 LHLPRLQELHLQENSIEL-LEDQALAGLSSLALLDLSRNQLGTISREALQPLASLQVLRL 201

Query: 182 SGNPWKCNCS 191
           + NPW+C+C+
Sbjct: 202 TENPWRCDCA 211


>gi|126517478 peroxidasin homolog-like [Homo sapiens]
          Length = 1463

 Score = 83.2 bits (204), Expect = 3e-16
 Identities = 66/216 (30%), Positives = 89/216 (41%), Gaps = 2/216 (0%)

Query: 13  LFSFGMGLVSGSKCPNNCLCQAQEVICTGKQLTEYPLDIPLNTRRLFLNENRITSLPAMH 72
           LF      + G  CP+ CLC    V C    L   P  +P  T  L L  NRI  +P   
Sbjct: 11  LFLLAGWCLPGLPCPSRCLCFKSTVRCMHLMLDHIP-QVPQQTTVLDLRFNRIREIPGSA 69

Query: 73  LGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFTFSVLSNLVQLNI 132
              L +L  L   NN IR++    F G+  L+YL L  N + ++   TF  L +L  L I
Sbjct: 70  FKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKGLISLEHLYI 129

Query: 133 ANNPHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFLSGNPWKCNCSF 192
             N  L  L   TF +   L  L L N  L  + + +  +L +L+ L L  N   C+C  
Sbjct: 130 HFN-QLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSFSNLDSLKRLRLDSNALVCDCDL 188

Query: 193 LDFAIFLIVFHMDPSDDLNATCVEPTELTGWPITRV 228
           +     L  F         ATC  P  L G  +  V
Sbjct: 189 MWLGELLQGFAQHGHTQAAATCEYPRRLHGRAVASV 224


>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
          Length = 713

 Score = 82.4 bits (202), Expect = 5e-16
 Identities = 64/182 (35%), Positives = 85/182 (46%), Gaps = 4/182 (2%)

Query: 3   LASGPGPGWLLFSFGMGLVSGSKCPNNCLC--QAQEVICTGKQLTEYPLDIPLNTRRLFL 60
           L +G G   +  + G G    + CP  C C  QA  VICT + L E P  IP+NTR L L
Sbjct: 34  LGAGGGGVAVTSAAGGGSPPATSCPVACSCSNQASRVICTRRDLAEVPASIPVNTRYLNL 93

Query: 61  NENRITSLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFT 120
            EN I  +       L  L  L    N +R++    F G+  L  L+L  N LT++    
Sbjct: 94  QENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQA 153

Query: 121 FSVLSNLVQLNIANNPHLLSLHKFTFANTTSLRYLDLRN-TGLQTLDSAALYHLTTLETL 179
           F  LS L +L + NNP + S+  + F    SLR LDL     L+ +  AA   L  L  L
Sbjct: 154 FEYLSKLRELWLRNNP-IESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYL 212

Query: 180 FL 181
            L
Sbjct: 213 NL 214



 Score = 28.5 bits (62), Expect = 8.0
 Identities = 14/32 (43%), Positives = 19/32 (59%)

Query: 153 RYLDLRNTGLQTLDSAALYHLTTLETLFLSGN 184
           RYL+L+  G+Q + +    HL  LE L LS N
Sbjct: 89  RYLNLQENGIQVIRTDTFKHLRHLEILQLSKN 120


>gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]
          Length = 2623

 Score = 79.7 bits (195), Expect = 3e-15
 Identities = 64/222 (28%), Positives = 94/222 (42%), Gaps = 38/222 (17%)

Query: 6   GPGPGWLLFSFGM----GLVSGSKCPNNCLC-QAQEVICTGKQLTEYPLDIPLNTRR--- 57
           G G   LL SF +        G  CP  C C    EV CT + LT  P  IP N  R   
Sbjct: 5   GRGITCLLVSFAVICLVATPGGKACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINL 64

Query: 58  ---------------------LFLNENRITSLPAMHLGLLSDLVYLDCQNNRIREVMDYT 96
                                L L+ N I ++P      L  L  L    N++R++   T
Sbjct: 65  GYNSLVRLMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQKDT 124

Query: 97  FIGVFKLIYLDLSSNNLTSISPFTFSVLSNLVQLNIANNPHLLSLHKFTFANTTSL---- 152
           F G+  L  L +  NN+  I+P  F  L+ L  +++  N  L  LH  TF + + L    
Sbjct: 125 FYGLRSLTRLHMDHNNIEFINPEVFYGLNFLRLVHLEGN-QLTKLHPDTFVSLSYLQIFK 183

Query: 153 ----RYLDLRNTGLQTLDSAALYHLTTLETLFLSGNPWKCNC 190
               ++L L +  L +L    + ++  L++L+L GNPW C+C
Sbjct: 184 ISFIKFLYLSDNFLTSLPQEMVSYMPDLDSLYLHGNPWTCDC 225


>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
           sapiens]
          Length = 592

 Score = 78.2 bits (191), Expect = 9e-15
 Identities = 61/170 (35%), Positives = 80/170 (47%), Gaps = 7/170 (4%)

Query: 26  CPNNCLC--QAQEVICTGKQLTEYPLDIPLNTRRLFLNENRITSLPAMHLGLLSDLVYLD 83
           CP  C C  Q + V CT ++LT  P  IP  TR L L+ NRI  L    L  L  L  LD
Sbjct: 25  CPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNPGDLAALPALEELD 84

Query: 84  CQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFTFSVLSNLVQLNIANNPHLLSLHK 143
              N I  V    F  + +L  L L  N L  I P  F+ L NL  L+++ N  L+ L  
Sbjct: 85  LSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSEN-KLVILLD 143

Query: 144 FTFANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFLSGNPWKCNCSFL 193
           +TF +  SLR L++ +  L  +   A   L  LE L L     +CN + L
Sbjct: 144 YTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLE----RCNLTAL 189



 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 41/159 (25%), Positives = 66/159 (41%), Gaps = 23/159 (14%)

Query: 58  LFLNENRITSLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSIS 117
           L L    I SL   +   L  L++L+  N  + E +    +    L  L ++  N+T++ 
Sbjct: 203 LRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGLNLTSLSVTHTNITAVP 262

Query: 118 PFTFSVLSNLVQLNIANNP-------------HLLSLHKF----------TFANTTSLRY 154
                  ++L  LN+++NP              L  LH             F     +R 
Sbjct: 263 AAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRL 322

Query: 155 LDLRNTGLQTLDSAALYHLTTLETLFLSGNPWKCNCSFL 193
           L+L N  L TL+ +  + + TLETL + GNP  C+C  L
Sbjct: 323 LNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRLL 361



 Score = 31.6 bits (70), Expect = 0.95
 Identities = 40/156 (25%), Positives = 60/156 (38%), Gaps = 25/156 (16%)

Query: 54  NTRRLFLNENRITSLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNL 113
           N   L L+EN++  L       L  L  L+  +N +  V    F G+  L  L L   NL
Sbjct: 127 NLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNL 186

Query: 114 TSISPFTFSVLSNLVQLNIANNPHLLSLHKFTFANTTSLRYLDLRN-------------- 159
           T++S  +   L +L  L +  +  + SL    F     L +L++ N              
Sbjct: 187 TALSGESLGHLRSLGALRL-RHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRG 245

Query: 160 ----------TGLQTLDSAALYHLTTLETLFLSGNP 185
                     T +  + +AAL H   L  L LS NP
Sbjct: 246 LNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNP 281


>gi|51317373 netrin-G1 ligand [Homo sapiens]
          Length = 640

 Score = 77.8 bits (190), Expect = 1e-14
 Identities = 55/141 (39%), Positives = 69/141 (48%), Gaps = 3/141 (2%)

Query: 19  GLVSGSKCPNNCLCQAQ--EVICTGKQLTEYPLDIPLNTRRLFLNENRITSLPAMHLGLL 76
           GLV    CP+ C C  Q  +VIC  K L E P  I  NTR L L+EN+I  +       L
Sbjct: 40  GLVRAQTCPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHL 99

Query: 77  SDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFTFSVLSNLVQLNIANNP 136
             L  L    N IR +    F G+  L  L+L  N LT+I    F  LS L +L + NNP
Sbjct: 100 RHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNP 159

Query: 137 HLLSLHKFTFANTTSLRYLDL 157
            + S+  + F    SLR LDL
Sbjct: 160 -IESIPSYAFNRIPSLRRLDL 179



 Score = 59.3 bits (142), Expect = 4e-09
 Identities = 54/169 (31%), Positives = 82/169 (48%), Gaps = 7/169 (4%)

Query: 56  RRLFLNE-NRITSLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLT 114
           RRL L E  R++ +       LS+L YL+     +RE+ + T   + KL  LDLS N+L+
Sbjct: 175 RRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLT--PLIKLDELDLSGNHLS 232

Query: 115 SISPFTFSVLSNLVQLNIANNPHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLT 174
           +I P +F  L +L +L +  +  +  + +  F N  SL  ++L +  L  L       L 
Sbjct: 233 AIRPGSFQGLMHLQKLWMIQS-QIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLH 291

Query: 175 TLETLFLSGNPWKCNCSFLDFAIFLIVFHMDPSDD-LNATCVEPTELTG 222
            LE + L  NPW CNC  L  + +  +  M PS+    A C  P  L G
Sbjct: 292 HLERIHLHHNPWNCNCDILWLSWW--IKDMAPSNTACCARCNTPPNLKG 338


>gi|88702793 slit-like 2 [Homo sapiens]
          Length = 673

 Score = 76.3 bits (186), Expect = 3e-14
 Identities = 67/220 (30%), Positives = 94/220 (42%), Gaps = 47/220 (21%)

Query: 9   PGWLLFSFGMGLVSGSKCPNNCLC-QAQEVICTGKQLTEYPLDIPLNTRRLF-------- 59
           P  LL + G G+     CP+ C C Q Q V CT +Q T  P D+P +T  L+        
Sbjct: 10  PLLLLLALGPGVQG---CPSGCQCSQPQTVFCTARQGTTVPRDVPPDTVGLYVFENGITM 66

Query: 60  ----------------LNENRITSLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKL 103
                           L++N+I SLP+     L++L  LD   NR+ E+ + TF G+ +L
Sbjct: 67  LDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETFRGLRRL 126

Query: 104 IYLDLSSNNLTSISPFTFSVLSNLVQLNIANN----------PHLLSL---HKFTFA--- 147
             L L  N +  I P  F  L  L++L + +N          P LL L   H    A   
Sbjct: 127 ERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPPLRLPRLLLLDLSHNSLLALEP 186

Query: 148 ---NTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFLSGN 184
              +T ++  L L   GLQ LD      L  L  L +S N
Sbjct: 187 GILDTANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDN 226



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 44/173 (25%), Positives = 71/173 (41%), Gaps = 3/173 (1%)

Query: 52  PLNTRRLFLNENRITSLPAMHLGLL--SDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLS 109
           PL   RL L +    SL A+  G+L  +++  L      ++++ +  F  +  L  LD+S
Sbjct: 165 PLRLPRLLLLDLSHNSLLALEPGILDTANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVS 224

Query: 110 SNNLTSISPFTFSVLSNLVQLNIANNPHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAA 169
            N L  + P     L  L +L +A N  +  L     A   +L+ LD+ N  LQ L    
Sbjct: 225 DNQLERVPP-VIRGLRGLTRLRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDL 283

Query: 170 LYHLTTLETLFLSGNPWKCNCSFLDFAIFLIVFHMDPSDDLNATCVEPTELTG 222
                 L  L  + NP+ C C    F  ++   H+  +      C  P +  G
Sbjct: 284 SGLFPRLRLLAAARNPFNCVCPLSWFGPWVRESHVTLASPEETRCHFPPKNAG 336


>gi|139948432 adlican [Homo sapiens]
          Length = 2828

 Score = 75.5 bits (184), Expect = 6e-14
 Identities = 57/198 (28%), Positives = 87/198 (43%), Gaps = 34/198 (17%)

Query: 26  CPNNCLCQA-QEVICTGKQLTEYPLDIPLNTRR------------------------LFL 60
           CP+ C C    EV CT + L   P  I  +  R                        L +
Sbjct: 27  CPHPCACYVPSEVHCTFRSLASVPAGIAKHVERINLGFNSIQALSETSFAGLTKLELLMI 86

Query: 61  NENRITSLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFT 120
           + N I S+P   L  LS L       N++R +   T  G+  L+ L +  N +  I P  
Sbjct: 87  HGNEIPSIPDGALRDLSSLQVFKFSYNKLRVITGQTLQGLSNLMRLHIDHNKIEFIHPQA 146

Query: 121 FSVLSNLVQLNIANNPHLLSLHKFTFANTT--------SLRYLDLRNTGLQTLDSAALYH 172
           F+ L++L  L++  N  L  LH  TF+  T        ++R+L L    ++TL ++ L +
Sbjct: 147 FNGLTSLRLLHLEGNL-LHQLHPSTFSTFTFLDYFRLSTIRHLYLAENMVRTLPASMLRN 205

Query: 173 LTTLETLFLSGNPWKCNC 190
           +  LE L+L GNPW C+C
Sbjct: 206 MPLLENLYLQGNPWTCDC 223


>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
           sapiens]
          Length = 587

 Score = 75.5 bits (184), Expect = 6e-14
 Identities = 60/195 (30%), Positives = 85/195 (43%), Gaps = 4/195 (2%)

Query: 31  LCQAQEVICTGKQLTEYPLDI--PL-NTRRLFLNENRITSLPAMHLGLLSDLVYLDCQNN 87
           L Q   +   G  L E  L I  P+ N R L+L +N I+SLP      L  L  L    N
Sbjct: 274 LPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRN 333

Query: 88  RIREVMDYTFIGVFKLIYLDLSSNNLTSISPFTFSVLSNLVQLNIANNPHLLSLHKFTFA 147
           +I  +    F G+ +L  L L +N L  +    F +L+NL  +++ NN  L  L    FA
Sbjct: 334 QISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNN-RLRQLPGNIFA 392

Query: 148 NTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFLSGNPWKCNCSFLDFAIFLIVFHMDPS 207
           N   L  + L+N  L+ L      HL  L  L L  NPW+C+   L    +L++      
Sbjct: 393 NVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLG 452

Query: 208 DDLNATCVEPTELTG 222
            D    C  P  + G
Sbjct: 453 TDTVPVCFSPANVRG 467



 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 49/171 (28%), Positives = 78/171 (45%), Gaps = 3/171 (1%)

Query: 15  SFGMGLVSGSKCPNNCLC-QAQEVICTGKQLTEYPLDIPLNTRRLFLNENRITSLPAMHL 73
           ++G GL     CP+ C C +A +V CTG ++   P  +P N   L +    IT L     
Sbjct: 21  AWGAGLAYHG-CPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPF 79

Query: 74  GLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFTFSVLSNLVQLNIA 133
             +S L+ L  + N +  +    F  +  L YL L++N L  +    F  L +L  L ++
Sbjct: 80  LNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLS 139

Query: 134 NNPHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFLSGN 184
           +N  LL +    F+  ++L+ L L    L+ +   A  HL  L  L L  N
Sbjct: 140 SN-QLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKN 189



 Score = 53.5 bits (127), Expect = 2e-07
 Identities = 37/127 (29%), Positives = 57/127 (44%), Gaps = 1/127 (0%)

Query: 58  LFLNENRITSLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSIS 117
           L L+ N++  +   H    S+L  L    N +  + D  F  +  L  L+L  N+LT IS
Sbjct: 136 LLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHIS 195

Query: 118 PFTFSVLSNLVQLNIANNPHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLTTLE 177
           P  F  L NL  L +  N  L  +   TF    +L+ L L+   +  L     ++   L+
Sbjct: 196 PRVFQHLGNLQVLRLYEN-RLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQ 254

Query: 178 TLFLSGN 184
            L+LS N
Sbjct: 255 RLYLSNN 261



 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 44/164 (26%), Positives = 66/164 (40%), Gaps = 9/164 (5%)

Query: 24  SKCPNNCLCQAQEVICTGKQLTEYP---LDIPLNTRRLFLNENRITSLPAMHLGLLSDLV 80
           S+C N      +E+   G  L   P    D  +   +L L +N +T +       L +L 
Sbjct: 152 SQCSN-----LKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQ 206

Query: 81  YLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFTFSVLSNLVQLNIANNPHLLS 140
            L    NR+ ++   TF G+  L  L L  N +  +SP  F    NL +L ++NN H+  
Sbjct: 207 VLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNN-HISQ 265

Query: 141 LHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFLSGN 184
           L    F     L  L L    L+ L       +  L  L+L  N
Sbjct: 266 LPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDN 309


>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
           sapiens]
          Length = 581

 Score = 75.5 bits (184), Expect = 6e-14
 Identities = 60/195 (30%), Positives = 85/195 (43%), Gaps = 4/195 (2%)

Query: 31  LCQAQEVICTGKQLTEYPLDI--PL-NTRRLFLNENRITSLPAMHLGLLSDLVYLDCQNN 87
           L Q   +   G  L E  L I  P+ N R L+L +N I+SLP      L  L  L    N
Sbjct: 268 LPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRN 327

Query: 88  RIREVMDYTFIGVFKLIYLDLSSNNLTSISPFTFSVLSNLVQLNIANNPHLLSLHKFTFA 147
           +I  +    F G+ +L  L L +N L  +    F +L+NL  +++ NN  L  L    FA
Sbjct: 328 QISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNN-RLRQLPGNIFA 386

Query: 148 NTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFLSGNPWKCNCSFLDFAIFLIVFHMDPS 207
           N   L  + L+N  L+ L      HL  L  L L  NPW+C+   L    +L++      
Sbjct: 387 NVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLG 446

Query: 208 DDLNATCVEPTELTG 222
            D    C  P  + G
Sbjct: 447 TDTVPVCFSPANVRG 461



 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 49/171 (28%), Positives = 78/171 (45%), Gaps = 3/171 (1%)

Query: 15  SFGMGLVSGSKCPNNCLC-QAQEVICTGKQLTEYPLDIPLNTRRLFLNENRITSLPAMHL 73
           ++G GL     CP+ C C +A +V CTG ++   P  +P N   L +    IT L     
Sbjct: 15  AWGAGLAYHG-CPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPF 73

Query: 74  GLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFTFSVLSNLVQLNIA 133
             +S L+ L  + N +  +    F  +  L YL L++N L  +    F  L +L  L ++
Sbjct: 74  LNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLS 133

Query: 134 NNPHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFLSGN 184
           +N  LL +    F+  ++L+ L L    L+ +   A  HL  L  L L  N
Sbjct: 134 SN-QLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKN 183



 Score = 53.5 bits (127), Expect = 2e-07
 Identities = 37/127 (29%), Positives = 57/127 (44%), Gaps = 1/127 (0%)

Query: 58  LFLNENRITSLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSIS 117
           L L+ N++  +   H    S+L  L    N +  + D  F  +  L  L+L  N+LT IS
Sbjct: 130 LLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHIS 189

Query: 118 PFTFSVLSNLVQLNIANNPHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLTTLE 177
           P  F  L NL  L +  N  L  +   TF    +L+ L L+   +  L     ++   L+
Sbjct: 190 PRVFQHLGNLQVLRLYEN-RLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQ 248

Query: 178 TLFLSGN 184
            L+LS N
Sbjct: 249 RLYLSNN 255



 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 44/164 (26%), Positives = 66/164 (40%), Gaps = 9/164 (5%)

Query: 24  SKCPNNCLCQAQEVICTGKQLTEYP---LDIPLNTRRLFLNENRITSLPAMHLGLLSDLV 80
           S+C N      +E+   G  L   P    D  +   +L L +N +T +       L +L 
Sbjct: 146 SQCSN-----LKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQ 200

Query: 81  YLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFTFSVLSNLVQLNIANNPHLLS 140
            L    NR+ ++   TF G+  L  L L  N +  +SP  F    NL +L ++NN H+  
Sbjct: 201 VLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNN-HISQ 259

Query: 141 LHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFLSGN 184
           L    F     L  L L    L+ L       +  L  L+L  N
Sbjct: 260 LPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDN 303


>gi|225579152 insulin-like growth factor binding protein, acid
           labile subunit isoform 1 precursor [Homo sapiens]
          Length = 643

 Score = 75.1 bits (183), Expect = 7e-14
 Identities = 53/172 (30%), Positives = 80/172 (46%), Gaps = 7/172 (4%)

Query: 19  GLVSGSKCPNNCLCQAQE------VICTGKQLTEYPLDIPLNTRRLFLNENRITSLPAMH 72
           G   G  CP  C+C   +      V C+ + LT  P  +P  T+ L+L+ N ++S+P   
Sbjct: 72  GEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAA 131

Query: 73  LGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFTFSVLSNLVQLNI 132
              LS L +L+ Q  ++  +     +G+  L +L L  N L S++  TF+    L  L +
Sbjct: 132 FQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGL 191

Query: 133 ANNPHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFLSGN 184
           +NN  L  L    F    SL  L+L    L  L  AA   L +L  L L+GN
Sbjct: 192 SNN-RLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGN 242



 Score = 59.7 bits (143), Expect = 3e-09
 Identities = 43/130 (33%), Positives = 70/130 (53%), Gaps = 3/130 (2%)

Query: 56  RRLFLNENRITSL-PAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLT 114
           ++L+L+ N I ++ P   LGL + L +LD  +NR+  +++ TF G+  L  L LS N + 
Sbjct: 283 QKLYLDRNLIAAVAPGAFLGLKA-LRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIA 341

Query: 115 SISPFTFSVLSNLVQLNIANNPHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLT 174
           S+ P TF  L  L +L + +N  +  L + +F     L  L L +  LQ + + A   LT
Sbjct: 342 SLRPRTFKDLHFLEELQLGHN-RIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLT 400

Query: 175 TLETLFLSGN 184
            +  + LSGN
Sbjct: 401 NVAVMNLSGN 410



 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 53/187 (28%), Positives = 73/187 (39%), Gaps = 44/187 (23%)

Query: 76  LSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFTFSVLSNLVQLNIANN 135
           LS L  L  ++N +  + + +  G+ +L+ LDL+SN LT +    F  L  L  L ++ N
Sbjct: 447 LSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRN 506

Query: 136 -----------------------PHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYH 172
                                    L +L     A    LRYL LRN  L+T        
Sbjct: 507 RLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQP--- 563

Query: 173 LTTLETLFLSGNPWKCNC---SFLDF------AIFLIVFHMDPSDDL--------NATCV 215
              LE L+L GNPW C C   +  DF      A+   V  +   DD         N TC 
Sbjct: 564 -PGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCA 622

Query: 216 EPTELTG 222
            P E+ G
Sbjct: 623 SPPEVVG 629



 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 45/155 (29%), Positives = 67/155 (43%), Gaps = 23/155 (14%)

Query: 53  LNTRRLFLNENRITSLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNN 112
           L  R L L+ N I SL       L  L  L   +NRIR++ + +F G+ +L  L L  N 
Sbjct: 328 LGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQ 387

Query: 113 LTSISPFTFSVLSNLVQLNIANN-------------PHLLSLH----------KFTFANT 149
           L  +    F  L+N+  +N++ N               L SLH            TF   
Sbjct: 388 LQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGL 447

Query: 150 TSLRYLDLRNTGLQTLDSAALYHLTTLETLFLSGN 184
           + LR L L++ GL  ++  +L+ L  L  L L+ N
Sbjct: 448 SGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSN 482



 Score = 43.1 bits (100), Expect = 3e-04
 Identities = 39/129 (30%), Positives = 57/129 (44%), Gaps = 1/129 (0%)

Query: 56  RRLFLNENRITSLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTS 115
           R L L+ N + ++ A     L  L  L    N I  V    F+G+  L +LDLS N +  
Sbjct: 259 RELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAG 318

Query: 116 ISPFTFSVLSNLVQLNIANNPHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLTT 175
           +   TF  L  L  L +++N  + SL   TF +   L  L L +  ++ L   +   L  
Sbjct: 319 LLEDTFPGLLGLRVLRLSHNA-IASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQ 377

Query: 176 LETLFLSGN 184
           LE L L  N
Sbjct: 378 LEVLTLDHN 386



 Score = 42.4 bits (98), Expect = 5e-04
 Identities = 28/91 (30%), Positives = 45/91 (49%), Gaps = 3/91 (3%)

Query: 31  LCQAQEVICTGKQLTEYPLDIPLNTRRL---FLNENRITSLPAMHLGLLSDLVYLDCQNN 87
           L +  E+  T  QLT  P  +     +L    L+ NR+  LPA  LG L    +LD  +N
Sbjct: 471 LAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHN 530

Query: 88  RIREVMDYTFIGVFKLIYLDLSSNNLTSISP 118
           R+  + +     + +L YL L +N+L + +P
Sbjct: 531 RLEALPNSLLAPLGRLRYLSLRNNSLRTFTP 561



 Score = 37.0 bits (84), Expect = 0.023
 Identities = 38/127 (29%), Positives = 53/127 (41%), Gaps = 1/127 (0%)

Query: 58  LFLNENRITSLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSIS 117
           L L  N +  LP      L  L  L    NR+  +    F G+ +L  LDLS N L +I 
Sbjct: 213 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 272

Query: 118 PFTFSVLSNLVQLNIANNPHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLTTLE 177
              F  L  L +L +  N  + ++    F    +LR+LDL +  +  L       L  L 
Sbjct: 273 ANVFVQLPRLQKLYLDRN-LIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLR 331

Query: 178 TLFLSGN 184
            L LS N
Sbjct: 332 VLRLSHN 338


>gi|4826772 insulin-like growth factor binding protein, acid labile
           subunit isoform 2 precursor [Homo sapiens]
          Length = 605

 Score = 75.1 bits (183), Expect = 7e-14
 Identities = 53/172 (30%), Positives = 80/172 (46%), Gaps = 7/172 (4%)

Query: 19  GLVSGSKCPNNCLCQAQE------VICTGKQLTEYPLDIPLNTRRLFLNENRITSLPAMH 72
           G   G  CP  C+C   +      V C+ + LT  P  +P  T+ L+L+ N ++S+P   
Sbjct: 34  GEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAA 93

Query: 73  LGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFTFSVLSNLVQLNI 132
              LS L +L+ Q  ++  +     +G+  L +L L  N L S++  TF+    L  L +
Sbjct: 94  FQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGL 153

Query: 133 ANNPHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFLSGN 184
           +NN  L  L    F    SL  L+L    L  L  AA   L +L  L L+GN
Sbjct: 154 SNN-RLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGN 204



 Score = 59.7 bits (143), Expect = 3e-09
 Identities = 43/130 (33%), Positives = 70/130 (53%), Gaps = 3/130 (2%)

Query: 56  RRLFLNENRITSL-PAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLT 114
           ++L+L+ N I ++ P   LGL + L +LD  +NR+  +++ TF G+  L  L LS N + 
Sbjct: 245 QKLYLDRNLIAAVAPGAFLGLKA-LRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIA 303

Query: 115 SISPFTFSVLSNLVQLNIANNPHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLT 174
           S+ P TF  L  L +L + +N  +  L + +F     L  L L +  LQ + + A   LT
Sbjct: 304 SLRPRTFKDLHFLEELQLGHN-RIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLT 362

Query: 175 TLETLFLSGN 184
            +  + LSGN
Sbjct: 363 NVAVMNLSGN 372



 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 53/187 (28%), Positives = 73/187 (39%), Gaps = 44/187 (23%)

Query: 76  LSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFTFSVLSNLVQLNIANN 135
           LS L  L  ++N +  + + +  G+ +L+ LDL+SN LT +    F  L  L  L ++ N
Sbjct: 409 LSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRN 468

Query: 136 -----------------------PHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYH 172
                                    L +L     A    LRYL LRN  L+T        
Sbjct: 469 RLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQP--- 525

Query: 173 LTTLETLFLSGNPWKCNC---SFLDF------AIFLIVFHMDPSDDL--------NATCV 215
              LE L+L GNPW C C   +  DF      A+   V  +   DD         N TC 
Sbjct: 526 -PGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCA 584

Query: 216 EPTELTG 222
            P E+ G
Sbjct: 585 SPPEVVG 591



 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 45/155 (29%), Positives = 67/155 (43%), Gaps = 23/155 (14%)

Query: 53  LNTRRLFLNENRITSLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNN 112
           L  R L L+ N I SL       L  L  L   +NRIR++ + +F G+ +L  L L  N 
Sbjct: 290 LGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQ 349

Query: 113 LTSISPFTFSVLSNLVQLNIANN-------------PHLLSLH----------KFTFANT 149
           L  +    F  L+N+  +N++ N               L SLH            TF   
Sbjct: 350 LQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGL 409

Query: 150 TSLRYLDLRNTGLQTLDSAALYHLTTLETLFLSGN 184
           + LR L L++ GL  ++  +L+ L  L  L L+ N
Sbjct: 410 SGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSN 444



 Score = 43.1 bits (100), Expect = 3e-04
 Identities = 39/129 (30%), Positives = 57/129 (44%), Gaps = 1/129 (0%)

Query: 56  RRLFLNENRITSLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTS 115
           R L L+ N + ++ A     L  L  L    N I  V    F+G+  L +LDLS N +  
Sbjct: 221 RELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAG 280

Query: 116 ISPFTFSVLSNLVQLNIANNPHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLTT 175
           +   TF  L  L  L +++N  + SL   TF +   L  L L +  ++ L   +   L  
Sbjct: 281 LLEDTFPGLLGLRVLRLSHNA-IASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQ 339

Query: 176 LETLFLSGN 184
           LE L L  N
Sbjct: 340 LEVLTLDHN 348



 Score = 42.4 bits (98), Expect = 5e-04
 Identities = 28/91 (30%), Positives = 45/91 (49%), Gaps = 3/91 (3%)

Query: 31  LCQAQEVICTGKQLTEYPLDIPLNTRRL---FLNENRITSLPAMHLGLLSDLVYLDCQNN 87
           L +  E+  T  QLT  P  +     +L    L+ NR+  LPA  LG L    +LD  +N
Sbjct: 433 LAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHN 492

Query: 88  RIREVMDYTFIGVFKLIYLDLSSNNLTSISP 118
           R+  + +     + +L YL L +N+L + +P
Sbjct: 493 RLEALPNSLLAPLGRLRYLSLRNNSLRTFTP 523



 Score = 37.0 bits (84), Expect = 0.023
 Identities = 38/127 (29%), Positives = 53/127 (41%), Gaps = 1/127 (0%)

Query: 58  LFLNENRITSLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSIS 117
           L L  N +  LP      L  L  L    NR+  +    F G+ +L  LDLS N L +I 
Sbjct: 175 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 234

Query: 118 PFTFSVLSNLVQLNIANNPHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLTTLE 177
              F  L  L +L +  N  + ++    F    +LR+LDL +  +  L       L  L 
Sbjct: 235 ANVFVQLPRLQKLYLDRN-LIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLR 293

Query: 178 TLFLSGN 184
            L LS N
Sbjct: 294 VLRLSHN 300


>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
           sapiens]
          Length = 593

 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 66/198 (33%), Positives = 89/198 (44%), Gaps = 12/198 (6%)

Query: 1   MSLASGPGPGW-----LLFSFGMGLVSGSKCPNNCLC--QAQEVICTGKQLTEYPLDIPL 53
           M  A+ P   W     LLF   +   SG  CP  C C  Q Q V+C  +QL   P  +PL
Sbjct: 1   MDAATAPKQAWPPWPPLLFLLLLPGGSGGSCPAVCDCTSQPQAVLCGHRQLEAVPGGLPL 60

Query: 54  NTRRLFLNENRITSLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNL 113
           +T  L L+ NR+  L    L  LS L  LD   N++  +    F G+  L+ L L  N L
Sbjct: 61  DTELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRL 120

Query: 114 TSISPFTFSVLSNLVQLNIANNPHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYHL 173
             + P  FS LS L  L++  N  +L L    F    SL+ L++ +  L  +   A   L
Sbjct: 121 RIMGPGVFSGLSALTLLDLRLNQIVLFLDG-AFGELGSLQKLEVGDNHLVFVAPGAFAGL 179

Query: 174 TTLETLFLSGNPWKCNCS 191
             L TL L     +CN S
Sbjct: 180 AKLSTLTLE----RCNLS 193



 Score = 49.3 bits (116), Expect = 4e-06
 Identities = 32/88 (36%), Positives = 44/88 (50%), Gaps = 1/88 (1%)

Query: 106 LDLSSNNLTSISPFTFSVLSNLVQLNIANNPHLLSLHKFTFANTTSLRYLDLRNTGLQTL 165
           LDLS N +++I     S L  L +L ++    L S+    F   T+   LD+ +  LQTL
Sbjct: 281 LDLSQNPISAIPARRLSPLVRLQELRLSG-ACLTSIAAHAFHGLTAFHLLDVADNALQTL 339

Query: 166 DSAALYHLTTLETLFLSGNPWKCNCSFL 193
           +  A      L TL LSGNP  C+C  L
Sbjct: 340 EETAFPSPDKLVTLRLSGNPLTCDCRLL 367



 Score = 35.8 bits (81), Expect = 0.050
 Identities = 23/81 (28%), Positives = 38/81 (46%)

Query: 56  RRLFLNENRITSLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTS 115
           R L L++N I+++PA  L  L  L  L      +  +  + F G+     LD++ N L +
Sbjct: 279 RVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQT 338

Query: 116 ISPFTFSVLSNLVQLNIANNP 136
           +    F     LV L ++ NP
Sbjct: 339 LEETAFPSPDKLVTLRLSGNP 359



 Score = 32.7 bits (73), Expect = 0.43
 Identities = 45/160 (28%), Positives = 62/160 (38%), Gaps = 32/160 (20%)

Query: 49  LDIPLNTRRLFLNENRITSLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDL 108
           LD+ LN   LFL+            G L  L  L+  +N +  V    F G+ KL  L L
Sbjct: 137 LDLRLNQIVLFLDGA---------FGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTL 187

Query: 109 SSNNLTSISPFTFSVLSNLV-----QLNIANNP-----HLLSLHKFTFANTTSLRYLD-- 156
              NL+++     + L  LV     +L+I   P      L  L +       SL  LD  
Sbjct: 188 ERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPG 247

Query: 157 -----------LRNTGLQTLDSAALYHLTTLETLFLSGNP 185
                      +    L ++   ALYHL+ L  L LS NP
Sbjct: 248 SLVGLNLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNP 287


>gi|194306623 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score = 73.6 bits (179), Expect = 2e-13
 Identities = 68/224 (30%), Positives = 99/224 (44%), Gaps = 12/224 (5%)

Query: 11  WLLFSFGMGLVSGSKCPNNCLC----QAQEVICTGKQLTEYPLDIPLNTRRLFLNENRIT 66
           WL+++  +G V+GS CP  C C      Q   C  K+L E P  +P N   L L+ N+IT
Sbjct: 8   WLVWAL-LG-VAGS-CPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKIT 64

Query: 67  SLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFTFSVLSN 126
            L       ++ +  L   +N +R V       + +L  LDLS N    IS F +S L N
Sbjct: 65  VLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHN---FISSFPWSDLRN 121

Query: 127 L--VQLNIANNPHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFLSGN 184
           L  +QL   N+  L SL +        LR L + N  L+TL       L+ L  L L  N
Sbjct: 122 LSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHN 181

Query: 185 PWKCNCSFLDFAIFLIVFHMDPSDDLNATCVEPTELTGWPITRV 228
           P+ C C  +    +     +   +  +  C  P  L G P+ R+
Sbjct: 182 PFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRL 225


>gi|194306621 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score = 73.6 bits (179), Expect = 2e-13
 Identities = 68/224 (30%), Positives = 99/224 (44%), Gaps = 12/224 (5%)

Query: 11  WLLFSFGMGLVSGSKCPNNCLC----QAQEVICTGKQLTEYPLDIPLNTRRLFLNENRIT 66
           WL+++  +G V+GS CP  C C      Q   C  K+L E P  +P N   L L+ N+IT
Sbjct: 8   WLVWAL-LG-VAGS-CPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKIT 64

Query: 67  SLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFTFSVLSN 126
            L       ++ +  L   +N +R V       + +L  LDLS N    IS F +S L N
Sbjct: 65  VLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHN---FISSFPWSDLRN 121

Query: 127 L--VQLNIANNPHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFLSGN 184
           L  +QL   N+  L SL +        LR L + N  L+TL       L+ L  L L  N
Sbjct: 122 LSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHN 181

Query: 185 PWKCNCSFLDFAIFLIVFHMDPSDDLNATCVEPTELTGWPITRV 228
           P+ C C  +    +     +   +  +  C  P  L G P+ R+
Sbjct: 182 PFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRL 225


>gi|39930401 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score = 73.6 bits (179), Expect = 2e-13
 Identities = 68/224 (30%), Positives = 99/224 (44%), Gaps = 12/224 (5%)

Query: 11  WLLFSFGMGLVSGSKCPNNCLC----QAQEVICTGKQLTEYPLDIPLNTRRLFLNENRIT 66
           WL+++  +G V+GS CP  C C      Q   C  K+L E P  +P N   L L+ N+IT
Sbjct: 8   WLVWAL-LG-VAGS-CPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKIT 64

Query: 67  SLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFTFSVLSN 126
            L       ++ +  L   +N +R V       + +L  LDLS N    IS F +S L N
Sbjct: 65  VLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHN---FISSFPWSDLRN 121

Query: 127 L--VQLNIANNPHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFLSGN 184
           L  +QL   N+  L SL +        LR L + N  L+TL       L+ L  L L  N
Sbjct: 122 LSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHN 181

Query: 185 PWKCNCSFLDFAIFLIVFHMDPSDDLNATCVEPTELTGWPITRV 228
           P+ C C  +    +     +   +  +  C  P  L G P+ R+
Sbjct: 182 PFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRL 225


>gi|194306618 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score = 73.6 bits (179), Expect = 2e-13
 Identities = 68/224 (30%), Positives = 99/224 (44%), Gaps = 12/224 (5%)

Query: 11  WLLFSFGMGLVSGSKCPNNCLC----QAQEVICTGKQLTEYPLDIPLNTRRLFLNENRIT 66
           WL+++  +G V+GS CP  C C      Q   C  K+L E P  +P N   L L+ N+IT
Sbjct: 8   WLVWAL-LG-VAGS-CPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKIT 64

Query: 67  SLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFTFSVLSN 126
            L       ++ +  L   +N +R V       + +L  LDLS N    IS F +S L N
Sbjct: 65  VLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHN---FISSFPWSDLRN 121

Query: 127 L--VQLNIANNPHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFLSGN 184
           L  +QL   N+  L SL +        LR L + N  L+TL       L+ L  L L  N
Sbjct: 122 LSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHN 181

Query: 185 PWKCNCSFLDFAIFLIVFHMDPSDDLNATCVEPTELTGWPITRV 228
           P+ C C  +    +     +   +  +  C  P  L G P+ R+
Sbjct: 182 PFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRL 225


>gi|31542244 leucine rich repeat and fibronectin type III domain
           containing 5 [Homo sapiens]
          Length = 719

 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 57/178 (32%), Positives = 82/178 (46%), Gaps = 6/178 (3%)

Query: 12  LLFSFGMGL-VSGSKCPNNCLCQAQE----VICTGKQLTEYPLDIPLNTRRLFLNENRIT 66
           L + F +G+ V    CP  C+CQ        +C  K L   P +I   T  L L +N +T
Sbjct: 5   LFYLFLIGIAVKAQICPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVT 64

Query: 67  SLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFTFSVLSN 126
           ++       ++ LV L    N I  +  + F  +  L  L L+SN LT I+   FS LSN
Sbjct: 65  NIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSN 124

Query: 127 LVQLNIANNPHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFLSGN 184
           L  L I NN  L  +    F +  +L  LDL    L+T+   A+  + +L TL L  N
Sbjct: 125 LHHL-ILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHN 181



 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 57/182 (31%), Positives = 83/182 (45%), Gaps = 23/182 (12%)

Query: 54  NTRRLFLNENRITSLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNL 113
           N R L LN NR+T +       LS+L +L   NN++  +    F  VF L  LDLS NNL
Sbjct: 100 NLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNL 159

Query: 114 TSISPFTFSVLSNLVQLNIANNPHLL--SLHKFTFANTTSLRYLDLRNTGLQTLDSAALY 171
            +I    +  +  +V L+  +  H +  ++ K TF++   +  LD+ +  LQ L    L+
Sbjct: 160 ETIP---WDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLF 216

Query: 172 H---------LTTLETLFLS--GNPWKCNCSFLDFAIFLIVFHMDPSDDLNATCVEPTEL 220
                     + +  T  LS  GNP  CNC        L +  +   DDL  TC  P  L
Sbjct: 217 QRAQVLATSGIISPSTFALSFGGNPLHCNCE------LLWLRRLSREDDLE-TCASPPLL 269

Query: 221 TG 222
           TG
Sbjct: 270 TG 271


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.139    0.430 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,769,797
Number of Sequences: 37866
Number of extensions: 502048
Number of successful extensions: 2906
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 173
Number of HSP's successfully gapped in prelim test: 66
Number of HSP's that attempted gapping in prelim test: 1512
Number of HSP's gapped (non-prelim): 653
length of query: 313
length of database: 18,247,518
effective HSP length: 102
effective length of query: 211
effective length of database: 14,385,186
effective search space: 3035274246
effective search space used: 3035274246
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.