Guide to the Human Genome
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Search of human proteins with 193083139

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|193083139 leucine rich repeat containing 32 precursor [Homo
sapiens]
         (662 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|193083139 leucine rich repeat containing 32 precursor [Homo s...  1303   0.0  
gi|5031707 leucine rich repeat containing 32 precursor [Homo sap...  1303   0.0  
gi|38348406 leucine rich repeat containing 33 [Homo sapiens]          311   2e-84
gi|225579152 insulin-like growth factor binding protein, acid la...   134   2e-31
gi|4826772 insulin-like growth factor binding protein, acid labi...   134   2e-31
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s...   121   2e-27
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa...   121   2e-27
gi|62912472 leucine-rich repeat-containing G protein-coupled rec...   119   1e-26
gi|4759146 slit homolog 2 [Homo sapiens]                              118   2e-26
gi|54607118 leucine-rich repeats and immunoglobulin-like domains...   115   1e-25
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo...   115   1e-25
gi|4504379 leucine-rich repeat-containing G protein-coupled rece...   114   4e-25
gi|157694513 leucine-rich repeat-containing G protein-coupled re...   113   5e-25
gi|45505137 podocan [Homo sapiens]                                    112   8e-25
gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]            112   1e-24
gi|226342933 podocan-like 1 isoform 2 [Homo sapiens]                  112   1e-24
gi|226342931 podocan-like 1 isoform 1 [Homo sapiens]                  112   1e-24
gi|20302168 toll-like receptor 8 [Homo sapiens]                       110   3e-24
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom...   110   4e-24
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo...   108   2e-23
gi|11321571 slit homolog 3 [Homo sapiens]                             108   2e-23
gi|4507531 toll-like receptor 3 [Homo sapiens]                        105   1e-22
gi|62912470 leucine-rich repeat-containing G protein-coupled rec...   105   2e-22
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]          104   2e-22
gi|12007646 nyctalopin precursor [Homo sapiens]                       103   7e-22
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]   102   9e-22
gi|194440719 chondroadherin-like [Homo sapiens]                       102   1e-21
gi|40255157 leucine-rich repeats and immunoglobulin-like domains...   101   3e-21
gi|4758460 glycoprotein V (platelet) [Homo sapiens]                   101   3e-21
gi|188528675 slit homolog 1 [Homo sapiens]                             98   3e-20

>gi|193083139 leucine rich repeat containing 32 precursor [Homo
           sapiens]
          Length = 662

 Score = 1303 bits (3372), Expect = 0.0
 Identities = 662/662 (100%), Positives = 662/662 (100%)

Query: 1   MRPQILLLLALLTLGLAAQHQDKVPCKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQ 60
           MRPQILLLLALLTLGLAAQHQDKVPCKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQ
Sbjct: 1   MRPQILLLLALLTLGLAAQHQDKVPCKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQ 60

Query: 61  LRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGL 120
           LRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGL
Sbjct: 61  LRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGL 120

Query: 121 GPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDL 180
           GPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDL
Sbjct: 121 GPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDL 180

Query: 181 HSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQ 240
           HSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQ
Sbjct: 181 HSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQ 240

Query: 241 AEFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSAL 300
           AEFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSAL
Sbjct: 241 AEFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSAL 300

Query: 301 PLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLG 360
           PLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLG
Sbjct: 301 PLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLG 360

Query: 361 SLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGN 420
           SLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGN
Sbjct: 361 SLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGN 420

Query: 421 RVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPGLE 480
           RVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPGLE
Sbjct: 421 RVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPGLE 480

Query: 481 VATGALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEV 540
           VATGALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEV
Sbjct: 481 VATGALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEV 540

Query: 541 LDLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLSCCGNGWLAAQLHQGRVDVDATQDLIC 600
           LDLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLSCCGNGWLAAQLHQGRVDVDATQDLIC
Sbjct: 541 LDLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLSCCGNGWLAAQLHQGRVDVDATQDLIC 600

Query: 601 RFSSQEEVSLSHVRPEDCEKGGLKNINLIIILTFILVSAILLTTLAACCCVRRQKFNQQY 660
           RFSSQEEVSLSHVRPEDCEKGGLKNINLIIILTFILVSAILLTTLAACCCVRRQKFNQQY
Sbjct: 601 RFSSQEEVSLSHVRPEDCEKGGLKNINLIIILTFILVSAILLTTLAACCCVRRQKFNQQY 660

Query: 661 KA 662
           KA
Sbjct: 661 KA 662


>gi|5031707 leucine rich repeat containing 32 precursor [Homo
           sapiens]
          Length = 662

 Score = 1303 bits (3372), Expect = 0.0
 Identities = 662/662 (100%), Positives = 662/662 (100%)

Query: 1   MRPQILLLLALLTLGLAAQHQDKVPCKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQ 60
           MRPQILLLLALLTLGLAAQHQDKVPCKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQ
Sbjct: 1   MRPQILLLLALLTLGLAAQHQDKVPCKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQ 60

Query: 61  LRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGL 120
           LRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGL
Sbjct: 61  LRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGL 120

Query: 121 GPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDL 180
           GPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDL
Sbjct: 121 GPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDL 180

Query: 181 HSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQ 240
           HSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQ
Sbjct: 181 HSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQ 240

Query: 241 AEFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSAL 300
           AEFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSAL
Sbjct: 241 AEFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSAL 300

Query: 301 PLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLG 360
           PLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLG
Sbjct: 301 PLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLG 360

Query: 361 SLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGN 420
           SLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGN
Sbjct: 361 SLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGN 420

Query: 421 RVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPGLE 480
           RVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPGLE
Sbjct: 421 RVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPGLE 480

Query: 481 VATGALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEV 540
           VATGALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEV
Sbjct: 481 VATGALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEV 540

Query: 541 LDLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLSCCGNGWLAAQLHQGRVDVDATQDLIC 600
           LDLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLSCCGNGWLAAQLHQGRVDVDATQDLIC
Sbjct: 541 LDLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLSCCGNGWLAAQLHQGRVDVDATQDLIC 600

Query: 601 RFSSQEEVSLSHVRPEDCEKGGLKNINLIIILTFILVSAILLTTLAACCCVRRQKFNQQY 660
           RFSSQEEVSLSHVRPEDCEKGGLKNINLIIILTFILVSAILLTTLAACCCVRRQKFNQQY
Sbjct: 601 RFSSQEEVSLSHVRPEDCEKGGLKNINLIIILTFILVSAILLTTLAACCCVRRQKFNQQY 660

Query: 661 KA 662
           KA
Sbjct: 661 KA 662


>gi|38348406 leucine rich repeat containing 33 [Homo sapiens]
          Length = 692

 Score =  311 bits (796), Expect = 2e-84
 Identities = 242/653 (37%), Positives = 325/653 (49%), Gaps = 43/653 (6%)

Query: 26  CKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEI 85
           CK+V     C+   L  VPS LPP    L L  N L+++    L  Y  L  L L +  +
Sbjct: 34  CKLVGGAADCRGQSLASVPSSLPPHARMLTLDANPLKTLWNHSLQPYPLLESLSLHSCHL 93

Query: 86  SFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLL 145
             +  GAFQ   HL  L L  N L+     +A  L  LP +  LDLSGN+L   +   +L
Sbjct: 94  ERISRGAFQEQGHLRSLVLGDNCLSENYEETAAALHALPGLRRLDLSGNALTEDMAALML 153

Query: 146 GEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLS 205
               SL ++SLA N++ RL    F  +  L +LDL  N + +IE GAF+GL  L HLNL+
Sbjct: 154 QNLSSLRSVSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNLA 213

Query: 206 RNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPDLAALP 265
            N+L CI DF L +LRVL++S N +E F  A+  +A F+L  LDL  N+LL FP L    
Sbjct: 214 FNNLPCIVDFGLTRLRVLNVSYNVLEWF-LATGGEAAFELETLDLSHNQLLFFPLLPQYS 272

Query: 266 RLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNA------------SGRP 313
           +L  L L +N +    G  +D     +P E  +   L    GN             S   
Sbjct: 273 KLRTLLLRDNNM----GFYRDLYNTSSPREMVAQFLL--VDGNVTNITTVSLWEEFSSSD 326

Query: 314 LSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHN 373
           L+ L  LD+S N+ + +PD FL  + SL  LNL +NCL T   R       L  LDLSHN
Sbjct: 327 LADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLHQNCLMTLHIREHEPPGALTELDLSHN 386

Query: 374 ALETLELG---ARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGP-- 428
            L  L L    A  LGSLR   L  N L  +PP  FAN  ++  L++  N++S C  P  
Sbjct: 387 QLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMSHNQISLCPLPAA 446

Query: 429 -DEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPGLEVATGALG 487
            D  GP  CV F  + SLRSLSL    +  L    F  T LT LDLSSN G  V  G+L 
Sbjct: 447 SDRVGPPSCVDFRNMASLRSLSLEGCGLGALPDCPFQGTSLTYLDLSSNWG--VLNGSLA 504

Query: 488 GLE---ASLEVLALQGNGL--MVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEVLD 542
            L+     L+VL+L+  GL    + +D   F  L+ L+L+ N L+  P +  +++LE LD
Sbjct: 505 PLQDVAPMLQVLSLRNMGLHSSFMALDFSGFGNLRDLDLSGNCLTTFPRFGGSLALETLD 564

Query: 543 LRNNSFSLLPGSAMG-GLETSLRRLYLQGNPLSCCG-NGWLAAQLHQGRVDVDATQDLIC 600
           LR NS + LP  A+   L   LR +YL  NP  CCG +GW A  L  G+   D    + C
Sbjct: 565 LRRNSLTALPQKAVSEQLSRGLRTIYLSQNPYDCCGVDGWGA--LQHGQTVADWAM-VTC 621

Query: 601 RFSSQ--EEVSLSHVRPEDCEKGGLKNINLIIILTFILVSAILLTTLAACCCV 651
             SS+      L    P DC+   L     + +L  +L+    LT L AC  +
Sbjct: 622 NLSSKIIRVTELPGGVPRDCKWERLD----LGLLYLVLILPSCLTLLVACTVI 670


>gi|225579152 insulin-like growth factor binding protein, acid
           labile subunit isoform 1 precursor [Homo sapiens]
          Length = 643

 Score =  134 bits (338), Expect = 2e-31
 Identities = 176/557 (31%), Positives = 226/557 (40%), Gaps = 88/557 (15%)

Query: 33  VSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGA 92
           V C    L ++P  +P  T+ L L GN L S+                         P A
Sbjct: 96  VFCSSRNLTRLPDGVPGGTQALWLDGNNLSSV------------------------PPAA 131

Query: 93  FQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLH 152
           FQ L+ L  L+L   +L        G L P                   + LLG     H
Sbjct: 132 FQNLSSLGFLNLQGGQL--------GSLEP-------------------QALLGLENLCH 164

Query: 153 TLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCI 212
            L L  N L  L   TF   PAL  L L +N L  +EDG FEGL  L  LNL  NSL  +
Sbjct: 165 -LHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVL 223

Query: 213 SDFS---LQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKL--LHFPDLAALPRL 267
            D +   L  LR L L+ N +   Q A       +L  LDL  N L  +       LPRL
Sbjct: 224 PDAAFRGLGSLRELVLAGNRLAYLQPALF-SGLAELRELDLSRNALRAIKANVFVQLPRL 282

Query: 268 IYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSG--NASGRPLSQLLNLDLSYN 325
             L L  NLI      P    G+ A    W  L  +  +G    +   L  L  L LS+N
Sbjct: 283 QKLYLDRNLIAAVA--PGAFLGLKALR--WLDLSHNRVAGLLEDTFPGLLGLRVLRLSHN 338

Query: 326 EIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGA-RA 384
            I  +     + L  L  L L  N +R    R    L  L +L L HN L+ ++ GA   
Sbjct: 339 AIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLG 398

Query: 385 LGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITS 444
           L ++  + L GN LR+LP   F  L  L  L+L+G+    C G   P       F+G++ 
Sbjct: 399 LTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGS----CLGRIRPH-----TFTGLSG 449

Query: 445 LRSLSLVDNE-IELLRAGAFLHTPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGL 503
           LR L L DN  + +     +    L ELDL+SN    +      GL   LE L L  N L
Sbjct: 450 LRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGL-GKLEYLLLSRNRL 508

Query: 504 MVLQVDLPCFICLKR---LNLAENRLSHLPAWTQAV--SLEVLDLRNNSFSLLPGSAMGG 558
             L  D      L+R   L+++ NRL  LP    A    L  L LRNNS         G 
Sbjct: 509 AELPAD--ALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPG- 565

Query: 559 LETSLRRLYLQGNPLSC 575
               L RL+L+GNP  C
Sbjct: 566 ----LERLWLEGNPWDC 578



 Score =  121 bits (304), Expect = 2e-27
 Identities = 136/426 (31%), Positives = 184/426 (43%), Gaps = 60/426 (14%)

Query: 54  LDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMAT 113
           L L  NQLRS+         AL  L LS N +S L+ G F+ L  L  L+L  N LA+  
Sbjct: 165 LHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLP 224

Query: 114 ALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMP 173
             +  GLG L     L L+GN L + L   L      L  L L+ N+L  +  + F  +P
Sbjct: 225 DAAFRGLGSL---RELVLAGNRL-AYLQPALFSGLAELRELDLSRNALRAIKANVFVQLP 280

Query: 174 ALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFS---LQQLRVLDLSCNSI 230
            L++L L  N++  +  GAF GL  L  L+LS N +  + + +   L  LRVL LS N+I
Sbjct: 281 RLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAI 340

Query: 231 EAFQTASQPQAEF-----------------------QLTWLDLRENKLLHFPDLA--ALP 265
            + +  +     F                       QL  L L  N+L      A   L 
Sbjct: 341 ASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLT 400

Query: 266 RLIYLNLSNNLIR-LPTGPPQDSKGIHAPSEGWSALPLSAP------SG----------- 307
            +  +NLS N +R LP    +    +H+     S L    P      SG           
Sbjct: 401 NVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGL 460

Query: 308 ----NASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLP 363
                 S   L++LL LDL+ N++  +P    + L  L +L LSRN L    A  LG L 
Sbjct: 461 VGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQ 520

Query: 364 CLMLLDLSHNALETLELGARA-LGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRV 422
               LD+SHN LE L     A LG LR L L+ N+LR   P        L+RL L+GN  
Sbjct: 521 RAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQP----PGLERLWLEGNPW 576

Query: 423 SPCGGP 428
             CG P
Sbjct: 577 D-CGCP 581



 Score =  100 bits (248), Expect = 6e-21
 Identities = 90/278 (32%), Positives = 124/278 (44%), Gaps = 29/278 (10%)

Query: 54  LDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMAT 113
           LDLS N++  +L         LR L LS N I+ L+P  F+ L  LE L L HNR+    
Sbjct: 309 LDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLA 368

Query: 114 ALSAGGLGP---------------------LPRVTSLDLSGNSLYSGLLERLLGEAPSLH 152
             S  GLG                      L  V  ++LSGN L   L E++      LH
Sbjct: 369 ERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL-RNLPEQVFRGLGKLH 427

Query: 153 TLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCI 212
           +L L  + L R+  HTF  +  L +L L  N L+ IE+ +  GL  L  L+L+ N LT +
Sbjct: 428 SLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHL 487

Query: 213 SDFSLQ---QLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPD--LAALPRL 267
                Q   +L  L LS N +      +    + +  WLD+  N+L   P+  LA L RL
Sbjct: 488 PHRLFQGLGKLEYLLLSRNRLAELPADALGPLQ-RAFWLDVSHNRLEALPNSLLAPLGRL 546

Query: 268 IYLNLSNNLIRLPTGPPQDSKGIHAPSEGWS-ALPLSA 304
            YL+L NN +R  T  P   + +      W    PL A
Sbjct: 547 RYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKA 584


>gi|4826772 insulin-like growth factor binding protein, acid labile
           subunit isoform 2 precursor [Homo sapiens]
          Length = 605

 Score =  134 bits (338), Expect = 2e-31
 Identities = 176/557 (31%), Positives = 226/557 (40%), Gaps = 88/557 (15%)

Query: 33  VSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGA 92
           V C    L ++P  +P  T+ L L GN L S+                         P A
Sbjct: 58  VFCSSRNLTRLPDGVPGGTQALWLDGNNLSSV------------------------PPAA 93

Query: 93  FQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLH 152
           FQ L+ L  L+L   +L        G L P                   + LLG     H
Sbjct: 94  FQNLSSLGFLNLQGGQL--------GSLEP-------------------QALLGLENLCH 126

Query: 153 TLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCI 212
            L L  N L  L   TF   PAL  L L +N L  +EDG FEGL  L  LNL  NSL  +
Sbjct: 127 -LHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVL 185

Query: 213 SDFS---LQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKL--LHFPDLAALPRL 267
            D +   L  LR L L+ N +   Q A       +L  LDL  N L  +       LPRL
Sbjct: 186 PDAAFRGLGSLRELVLAGNRLAYLQPALF-SGLAELRELDLSRNALRAIKANVFVQLPRL 244

Query: 268 IYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSG--NASGRPLSQLLNLDLSYN 325
             L L  NLI      P    G+ A    W  L  +  +G    +   L  L  L LS+N
Sbjct: 245 QKLYLDRNLIAAVA--PGAFLGLKALR--WLDLSHNRVAGLLEDTFPGLLGLRVLRLSHN 300

Query: 326 EIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGA-RA 384
            I  +     + L  L  L L  N +R    R    L  L +L L HN L+ ++ GA   
Sbjct: 301 AIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLG 360

Query: 385 LGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITS 444
           L ++  + L GN LR+LP   F  L  L  L+L+G+    C G   P       F+G++ 
Sbjct: 361 LTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGS----CLGRIRPH-----TFTGLSG 411

Query: 445 LRSLSLVDNE-IELLRAGAFLHTPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGL 503
           LR L L DN  + +     +    L ELDL+SN    +      GL   LE L L  N L
Sbjct: 412 LRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGL-GKLEYLLLSRNRL 470

Query: 504 MVLQVDLPCFICLKR---LNLAENRLSHLPAWTQAV--SLEVLDLRNNSFSLLPGSAMGG 558
             L  D      L+R   L+++ NRL  LP    A    L  L LRNNS         G 
Sbjct: 471 AELPAD--ALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPG- 527

Query: 559 LETSLRRLYLQGNPLSC 575
               L RL+L+GNP  C
Sbjct: 528 ----LERLWLEGNPWDC 540



 Score =  121 bits (304), Expect = 2e-27
 Identities = 136/426 (31%), Positives = 184/426 (43%), Gaps = 60/426 (14%)

Query: 54  LDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMAT 113
           L L  NQLRS+         AL  L LS N +S L+ G F+ L  L  L+L  N LA+  
Sbjct: 127 LHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLP 186

Query: 114 ALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMP 173
             +  GLG L     L L+GN L + L   L      L  L L+ N+L  +  + F  +P
Sbjct: 187 DAAFRGLGSL---RELVLAGNRL-AYLQPALFSGLAELRELDLSRNALRAIKANVFVQLP 242

Query: 174 ALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFS---LQQLRVLDLSCNSI 230
            L++L L  N++  +  GAF GL  L  L+LS N +  + + +   L  LRVL LS N+I
Sbjct: 243 RLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAI 302

Query: 231 EAFQTASQPQAEF-----------------------QLTWLDLRENKLLHFPDLA--ALP 265
            + +  +     F                       QL  L L  N+L      A   L 
Sbjct: 303 ASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLT 362

Query: 266 RLIYLNLSNNLIR-LPTGPPQDSKGIHAPSEGWSALPLSAP------SG----------- 307
            +  +NLS N +R LP    +    +H+     S L    P      SG           
Sbjct: 363 NVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGL 422

Query: 308 ----NASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLP 363
                 S   L++LL LDL+ N++  +P    + L  L +L LSRN L    A  LG L 
Sbjct: 423 VGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQ 482

Query: 364 CLMLLDLSHNALETLELGARA-LGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRV 422
               LD+SHN LE L     A LG LR L L+ N+LR   P        L+RL L+GN  
Sbjct: 483 RAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQP----PGLERLWLEGNPW 538

Query: 423 SPCGGP 428
             CG P
Sbjct: 539 D-CGCP 543



 Score =  100 bits (248), Expect = 6e-21
 Identities = 90/278 (32%), Positives = 124/278 (44%), Gaps = 29/278 (10%)

Query: 54  LDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMAT 113
           LDLS N++  +L         LR L LS N I+ L+P  F+ L  LE L L HNR+    
Sbjct: 271 LDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLA 330

Query: 114 ALSAGGLGP---------------------LPRVTSLDLSGNSLYSGLLERLLGEAPSLH 152
             S  GLG                      L  V  ++LSGN L   L E++      LH
Sbjct: 331 ERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL-RNLPEQVFRGLGKLH 389

Query: 153 TLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCI 212
           +L L  + L R+  HTF  +  L +L L  N L+ IE+ +  GL  L  L+L+ N LT +
Sbjct: 390 SLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHL 449

Query: 213 SDFSLQ---QLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPD--LAALPRL 267
                Q   +L  L LS N +      +    + +  WLD+  N+L   P+  LA L RL
Sbjct: 450 PHRLFQGLGKLEYLLLSRNRLAELPADALGPLQ-RAFWLDVSHNRLEALPNSLLAPLGRL 508

Query: 268 IYLNLSNNLIRLPTGPPQDSKGIHAPSEGWS-ALPLSA 304
            YL+L NN +R  T  P   + +      W    PL A
Sbjct: 509 RYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKA 546


>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
           sapiens]
          Length = 587

 Score =  121 bits (303), Expect = 2e-27
 Identities = 136/456 (29%), Positives = 192/456 (42%), Gaps = 77/456 (16%)

Query: 32  KVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPG 91
           +V C    ++ VP+ LP +  +L +    +  +  SP    +AL  L +  NE+S + PG
Sbjct: 42  QVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPG 101

Query: 92  AFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSL 151
           AF+ L  L +LSLA+N+L +                        L+ GL         SL
Sbjct: 102 AFRNLGSLRYLSLANNKLQVLPI--------------------GLFQGL--------DSL 133

Query: 152 HTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTC 211
            +L L+ N L ++    F     L++L LH N L  I DGAF+ L  LT LNL +NSLT 
Sbjct: 134 ESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTH 193

Query: 212 ISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFP--DLAALPRLIY 269
           IS    Q L  L +                      L L EN+L   P      L  L  
Sbjct: 194 ISPRVFQHLGNLQV----------------------LRLYENRLTDIPMGTFDGLVNLQE 231

Query: 270 LNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRP------LSQLLNLDLS 323
           L L  N I L       S G+   +     L LS  + + S  P      L QL  L L 
Sbjct: 232 LALQQNQIGLL------SPGLFHNNHNLQRLYLS--NNHISQLPPSIFMQLPQLNRLTLF 283

Query: 324 YNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGA- 382
            N ++ +       + +L  L L  N + +       +L  L +L LS N +  +  GA 
Sbjct: 284 GNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAF 343

Query: 383 RALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGI 442
             L  LR L L  NAL+DL    F  LA+LQ ++LQ NR+    G           F+ +
Sbjct: 344 NGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGN---------IFANV 394

Query: 443 TSLRSLSLVDNEIELLRAGAFLHT-PLTELDLSSNP 477
             L ++ L +N++E L  G F H   L EL L  NP
Sbjct: 395 NGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNP 430



 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 127/416 (30%), Positives = 173/416 (41%), Gaps = 62/416 (14%)

Query: 145 LGEAPSLH-----TLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRL 199
           L E+P L+      L + +N L+R+T   FR++ +L  L L +N L  +  G F+GL  L
Sbjct: 74  LNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSL 133

Query: 200 THLNLSRNSLTCISDFSLQQ---LRVLDLSCNSIEAFQTASQPQAEFQ----LTWLDLRE 252
             L LS N L  I      Q   L+ L L  N +E       P   F     LT L+L +
Sbjct: 134 ESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYI-----PDGAFDHLVGLTKLNLGK 188

Query: 253 NKLLHFPDLAALPRLIYLNLSN-NLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASG 311
           N L H       PR ++ +L N  ++RL      D                  P G   G
Sbjct: 189 NSLTHIS-----PR-VFQHLGNLQVLRLYENRLTD-----------------IPMGTFDG 225

Query: 312 RPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLS 371
             L  L  L L  N+I L+      +  +L  L LS N +          LP L  L L 
Sbjct: 226 --LVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLF 283

Query: 372 HNALETLELGARA-LGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDE 430
            N+L+ L LG    + +LR L L  N +  LP   F+NL  LQ L L  N++S       
Sbjct: 284 GNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFIS---- 339

Query: 431 PGPSGCVAFSGITSLRSLSLVDNEIELLRAGAF-LHTPLTELDLSSNPGLEVATGALGGL 489
           PG     AF+G+T LR LSL  N ++ L    F +   L  + L +N  L    G +   
Sbjct: 340 PG-----AFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNN-RLRQLPGNIFAN 393

Query: 490 EASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEVLDLRN 545
              L  + LQ N L     +LP  I      L E RL   P W      ++L LRN
Sbjct: 394 VNGLMAIQLQNNQL----ENLPLGIFDHLGKLCELRLYDNP-W--RCDSDILPLRN 442



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 87/267 (32%), Positives = 120/267 (44%), Gaps = 16/267 (5%)

Query: 312 RPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLS 371
           R L  L  L L+ N+++++P    + L SL  L LS N L   +         L  L L 
Sbjct: 104 RNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLH 163

Query: 372 HNALETLELGA-RALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDE 430
            N LE +  GA   L  L  L L  N+L  + P  F +L +LQ L L  NR++       
Sbjct: 164 GNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDI----- 218

Query: 431 PGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHT-PLTELDLSSNPGLEVATGALGGL 489
             P G   F G+ +L+ L+L  N+I LL  G F +   L  L LS+N   ++       L
Sbjct: 219 --PMG--TFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQL 274

Query: 490 EASLEVLALQGNGLMVLQVDL-PCFICLKRLNLAENRLSHLP--AWTQAVSLEVLDLRNN 546
              L  L L GN L  L + +      L+ L L +N +S LP   ++    L+VL L  N
Sbjct: 275 -PQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRN 333

Query: 547 SFSLLPGSAMGGLETSLRRLYLQGNPL 573
             S +   A  GL T LR L L  N L
Sbjct: 334 QISFISPGAFNGL-TELRELSLHTNAL 359



 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 56/194 (28%), Positives = 91/194 (46%), Gaps = 15/194 (7%)

Query: 390 TLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLS 449
           +L +    + +L    F N+++L  L ++ N +S       PG     AF  + SLR LS
Sbjct: 63  SLQILNTHITELNESPFLNISALIALRIEKNELSRI----TPG-----AFRNLGSLRYLS 113

Query: 450 LVDNEIELLRAGAFLH-TPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGL-MVLQ 507
           L +N++++L  G F     L  L LSSN  L++         ++L+ L L GN L  +  
Sbjct: 114 LANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQC-SNLKELQLHGNHLEYIPD 172

Query: 508 VDLPCFICLKRLNLAENRLSHLP--AWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRR 565
                 + L +LNL +N L+H+    +    +L+VL L  N  + +P     GL  +L+ 
Sbjct: 173 GAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGL-VNLQE 231

Query: 566 LYLQGNPLSCCGNG 579
           L LQ N +     G
Sbjct: 232 LALQQNQIGLLSPG 245


>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
           sapiens]
          Length = 581

 Score =  121 bits (303), Expect = 2e-27
 Identities = 136/456 (29%), Positives = 192/456 (42%), Gaps = 77/456 (16%)

Query: 32  KVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPG 91
           +V C    ++ VP+ LP +  +L +    +  +  SP    +AL  L +  NE+S + PG
Sbjct: 36  QVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPG 95

Query: 92  AFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSL 151
           AF+ L  L +LSLA+N+L +                        L+ GL         SL
Sbjct: 96  AFRNLGSLRYLSLANNKLQVLPI--------------------GLFQGL--------DSL 127

Query: 152 HTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTC 211
            +L L+ N L ++    F     L++L LH N L  I DGAF+ L  LT LNL +NSLT 
Sbjct: 128 ESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTH 187

Query: 212 ISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFP--DLAALPRLIY 269
           IS    Q L  L +                      L L EN+L   P      L  L  
Sbjct: 188 ISPRVFQHLGNLQV----------------------LRLYENRLTDIPMGTFDGLVNLQE 225

Query: 270 LNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRP------LSQLLNLDLS 323
           L L  N I L       S G+   +     L LS  + + S  P      L QL  L L 
Sbjct: 226 LALQQNQIGLL------SPGLFHNNHNLQRLYLS--NNHISQLPPSIFMQLPQLNRLTLF 277

Query: 324 YNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGA- 382
            N ++ +       + +L  L L  N + +       +L  L +L LS N +  +  GA 
Sbjct: 278 GNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAF 337

Query: 383 RALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGI 442
             L  LR L L  NAL+DL    F  LA+LQ ++LQ NR+    G           F+ +
Sbjct: 338 NGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGN---------IFANV 388

Query: 443 TSLRSLSLVDNEIELLRAGAFLHT-PLTELDLSSNP 477
             L ++ L +N++E L  G F H   L EL L  NP
Sbjct: 389 NGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNP 424



 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 127/416 (30%), Positives = 173/416 (41%), Gaps = 62/416 (14%)

Query: 145 LGEAPSLH-----TLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRL 199
           L E+P L+      L + +N L+R+T   FR++ +L  L L +N L  +  G F+GL  L
Sbjct: 68  LNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSL 127

Query: 200 THLNLSRNSLTCISDFSLQQ---LRVLDLSCNSIEAFQTASQPQAEFQ----LTWLDLRE 252
             L LS N L  I      Q   L+ L L  N +E       P   F     LT L+L +
Sbjct: 128 ESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYI-----PDGAFDHLVGLTKLNLGK 182

Query: 253 NKLLHFPDLAALPRLIYLNLSN-NLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASG 311
           N L H       PR ++ +L N  ++RL      D                  P G   G
Sbjct: 183 NSLTHIS-----PR-VFQHLGNLQVLRLYENRLTD-----------------IPMGTFDG 219

Query: 312 RPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLS 371
             L  L  L L  N+I L+      +  +L  L LS N +          LP L  L L 
Sbjct: 220 --LVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLF 277

Query: 372 HNALETLELGARA-LGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDE 430
            N+L+ L LG    + +LR L L  N +  LP   F+NL  LQ L L  N++S       
Sbjct: 278 GNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFIS---- 333

Query: 431 PGPSGCVAFSGITSLRSLSLVDNEIELLRAGAF-LHTPLTELDLSSNPGLEVATGALGGL 489
           PG     AF+G+T LR LSL  N ++ L    F +   L  + L +N  L    G +   
Sbjct: 334 PG-----AFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNN-RLRQLPGNIFAN 387

Query: 490 EASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEVLDLRN 545
              L  + LQ N L     +LP  I      L E RL   P W      ++L LRN
Sbjct: 388 VNGLMAIQLQNNQL----ENLPLGIFDHLGKLCELRLYDNP-W--RCDSDILPLRN 436



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 87/267 (32%), Positives = 120/267 (44%), Gaps = 16/267 (5%)

Query: 312 RPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLS 371
           R L  L  L L+ N+++++P    + L SL  L LS N L   +         L  L L 
Sbjct: 98  RNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLH 157

Query: 372 HNALETLELGA-RALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDE 430
            N LE +  GA   L  L  L L  N+L  + P  F +L +LQ L L  NR++       
Sbjct: 158 GNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDI----- 212

Query: 431 PGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHT-PLTELDLSSNPGLEVATGALGGL 489
             P G   F G+ +L+ L+L  N+I LL  G F +   L  L LS+N   ++       L
Sbjct: 213 --PMG--TFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQL 268

Query: 490 EASLEVLALQGNGLMVLQVDL-PCFICLKRLNLAENRLSHLP--AWTQAVSLEVLDLRNN 546
              L  L L GN L  L + +      L+ L L +N +S LP   ++    L+VL L  N
Sbjct: 269 -PQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRN 327

Query: 547 SFSLLPGSAMGGLETSLRRLYLQGNPL 573
             S +   A  GL T LR L L  N L
Sbjct: 328 QISFISPGAFNGL-TELRELSLHTNAL 353



 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 56/194 (28%), Positives = 91/194 (46%), Gaps = 15/194 (7%)

Query: 390 TLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLS 449
           +L +    + +L    F N+++L  L ++ N +S       PG     AF  + SLR LS
Sbjct: 57  SLQILNTHITELNESPFLNISALIALRIEKNELSRI----TPG-----AFRNLGSLRYLS 107

Query: 450 LVDNEIELLRAGAFLH-TPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGL-MVLQ 507
           L +N++++L  G F     L  L LSSN  L++         ++L+ L L GN L  +  
Sbjct: 108 LANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQC-SNLKELQLHGNHLEYIPD 166

Query: 508 VDLPCFICLKRLNLAENRLSHLP--AWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRR 565
                 + L +LNL +N L+H+    +    +L+VL L  N  + +P     GL  +L+ 
Sbjct: 167 GAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGL-VNLQE 225

Query: 566 LYLQGNPLSCCGNG 579
           L LQ N +     G
Sbjct: 226 LALQQNQIGLLSPG 239


>gi|62912472 leucine-rich repeat-containing G protein-coupled
           receptor 6 isoform 2 [Homo sapiens]
          Length = 915

 Score =  119 bits (297), Expect = 1e-26
 Identities = 128/408 (31%), Positives = 181/408 (44%), Gaps = 47/408 (11%)

Query: 79  DLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYS 138
           DLS N ++ LQPG F  L  LE L L+ N L+     +  GL  L     L L  N L  
Sbjct: 20  DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSL---KILMLQNNQL-G 75

Query: 139 GLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPR 198
           G+    L E PSL +L L  N ++ +   +F  + +L  L L  N L +I   A   LP 
Sbjct: 76  GIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPA 135

Query: 199 LTHLNLSRNSLTCISDFSLQQLR---VLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKL 255
           L  + L+ N ++ I D++ Q L    VL L  N I+   T S  +    L  LDL  NKL
Sbjct: 136 LQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSF-EGLHNLETLDLNYNKL 194

Query: 256 LHFP-DLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAP--------- 305
             FP  +  L RL  L   NN I+              P + +   PL            
Sbjct: 195 QEFPVAIRTLGRLQELGFHNNNIKA------------IPEKAFMGNPLLQTIHFYDNPIQ 242

Query: 306 -SGNASGRPLSQLLNLDLS-YNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLP 363
             G ++ + L +L  L L+   +I+  PD  L+  TSL  L L+R  +R   +     LP
Sbjct: 243 FVGRSAFQYLPKLHTLSLNGAMDIQEFPD--LKGTTSLEILTLTRAGIRLLPSGMCQQLP 300

Query: 364 CLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVS 423
            L +L+LSHN +E L         L  + LQ N + ++   TF+ L+SLQ L+L  N + 
Sbjct: 301 RLRVLELSHNQIEELP-SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIR 359

Query: 424 PCGGPDEPGPSGCVAFSGITSLRSLSLVDNE---IELLRAGAFLHTPL 468
               P+        AFS + SL  L L DN+   + L   G  +H  L
Sbjct: 360 SI-HPE--------AFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKL 398



 Score = 84.0 bits (206), Expect = 4e-16
 Identities = 118/419 (28%), Positives = 171/419 (40%), Gaps = 63/419 (15%)

Query: 179 DLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQ 238
           DL  N L +++ G F  L  L  L LS N L+ I   +   L                  
Sbjct: 20  DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGL------------------ 61

Query: 239 PQAEFQLTWLDLRENKLLHFPDLAA--LPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEG 296
               + L  L L+ N+L   P  A   LP L  L L  NLI L   P +  +G+ +    
Sbjct: 62  ----YSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLV--PERSFEGLSSLRHL 115

Query: 297 W------SALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNC 350
           W      + +P+ A +       L  L  + L+ N I  IPD   ++LTSL  L+L  N 
Sbjct: 116 WLDDNALTEIPVRALNN------LPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNR 169

Query: 351 LRTFEARRLGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLA 410
           ++         L  L  LDL++N L+   +  R LG L+ L    N ++ +P   F    
Sbjct: 170 IQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNP 229

Query: 411 SLQRLNLQGNRVSPCGGP-----------DEPGPSGCVAF---SGITSLRSLSLVDNEIE 456
            LQ ++   N +   G                G      F    G TSL  L+L    I 
Sbjct: 230 LLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIR 289

Query: 457 LLRAGAFLHTP-LTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVD-LPCFI 514
           LL +G     P L  L+LS N   E+   +L   +  LE + LQ N +  +  D      
Sbjct: 290 LLPSGMCQQLPRLRVLELSHNQIEELP--SLHRCQ-KLEEIGLQHNRIWEIGADTFSQLS 346

Query: 515 CLKRLNLAEN--RLSHLPAWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRLYLQGN 571
            L+ L+L+ N  R  H  A++   SL  LDL +N  + LP + +GG    L  L L+GN
Sbjct: 347 SLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGG----LMHLKLKGN 401



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 91/351 (25%), Positives = 138/351 (39%), Gaps = 38/351 (10%)

Query: 49  PDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNR 108
           P  ++L L  N +  +        ++LRHL L  N ++ +   A   L  L+ ++LA NR
Sbjct: 86  PSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNR 145

Query: 109 LAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHT 168
           ++     +   L  L     L L  N +   L         +L TL L  N L       
Sbjct: 146 ISHIPDYAFQNLTSL---VVLHLHNNRI-QHLGTHSFEGLHNLETLDLNYNKLQEFP-VA 200

Query: 169 FRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQL-RVLDLSC 227
            R +  L++L  H+N +  I + AF G P L  ++   N +  +   + Q L ++  LS 
Sbjct: 201 IRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSL 260

Query: 228 NSIEAFQTASQPQAEFQLTWLDLRENKLLHFPD--LAALPRLIYLNLSNNLIRLPTGPPQ 285
           N     Q     +    L  L L    +   P      LPRL  L LS+N I       +
Sbjct: 261 NGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQI-------E 313

Query: 286 DSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLN 345
           +   +H                        +L  + L +N I  I       L+SL  L+
Sbjct: 314 ELPSLHR---------------------CQKLEEIGLQHNRIWEIGADTFSQLSSLQALD 352

Query: 346 LSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGN 396
           LS N +R+       +L  L+ LDL+ N L TL L    LG L  L L+GN
Sbjct: 353 LSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLA--GLGGLMHLKLKGN 401


>gi|4759146 slit homolog 2 [Homo sapiens]
          Length = 1529

 Score =  118 bits (295), Expect = 2e-26
 Identities = 125/427 (29%), Positives = 179/427 (41%), Gaps = 26/427 (6%)

Query: 9   LALLTLGLAAQHQDKVPCKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASP 68
           L L  L   A       C      V C  L L  VP  +P +TE LDL+GN +  I  + 
Sbjct: 15  LVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTD 74

Query: 69  LGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTS 128
                 LR L L  N+IS ++ GAFQ L  LE L L  N L +   L   G   L R   
Sbjct: 75  FAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYR--- 131

Query: 129 LDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDI 188
           LDLS N +   +  +    A  +  L L  N ++ +    FR +  LE L L++N +  +
Sbjct: 132 LDLSENQI-QAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRL 190

Query: 189 EDGAFEGLPRLTHLNLSRNSLTC------ISDFSLQQLRV-LDLSC---NSIEAFQTASQ 238
              +F  +P+L    L  N+L C      +SD+  Q+ RV L   C   + +     A  
Sbjct: 191 SVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEV 250

Query: 239 PQAEFQLTW---LDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSE 295
            + EF  +           +LH P        I       L  +PT  P+    I     
Sbjct: 251 QKREFVCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQN 310

Query: 296 GWSALPLSAPSGNASGRPLSQLLNLDLSYNEI-ELIPDSFLEHLTSLCFLNLSRNCLRTF 354
               +P  A S      P  +L  +DLS N+I EL PD+F + L SL  L L  N +   
Sbjct: 311 TIKVIPPGAFS------PYKKLRRIDLSNNQISELAPDAF-QGLRSLNSLVLYGNKITEL 363

Query: 355 EARRLGSLPCLMLLDLSHNALETLELGA-RALGSLRTLLLQGNALRDLPPYTFANLASLQ 413
                  L  L LL L+ N +  L + A + L +L  L L  N L+ +   TF+ L ++Q
Sbjct: 364 PKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQ 423

Query: 414 RLNLQGN 420
            ++L  N
Sbjct: 424 TMHLAQN 430



 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 149/608 (24%), Positives = 234/608 (38%), Gaps = 95/608 (15%)

Query: 26  CKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEI 85
           C   +  V C+  GL ++P+ LP     + L  N ++ I       Y  LR +DLS N+I
Sbjct: 277 CTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQI 336

Query: 86  SFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLL 145
           S L P AFQ L  L  L L  N++             LP+         SL+ GL     
Sbjct: 337 SELAPDAFQGLRSLNSLVLYGNKIT-----------ELPK---------SLFEGLF---- 372

Query: 146 GEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLS 205
               SL  L L  N +  L    F+D+  L  L L+ N L  I  G F  L  +  ++L+
Sbjct: 373 ----SLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLA 428

Query: 206 RNSLTC------ISDF------------SLQQLRVLDLSCNSIEAFQTASQPQAEFQLTW 247
           +N   C      ++D+                 R+ +     I++ +     + ++ +  
Sbjct: 429 QNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPG 488

Query: 248 LDLRENKLLH--FPDLAALPRL----IYLNLSN-NLIRLPTGPPQDSKGIHAPSEGWSAL 300
            +   +KL    F DLA   +       ++ SN  L ++P   PQ +  +   +  ++ L
Sbjct: 489 TEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVL 548

Query: 301 PLSAPSGNASG--RPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARR 358
                   A+G  + L QL  ++ S N+I  I +   E  + +  + L+ N L   + + 
Sbjct: 549 -------EATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKM 601

Query: 359 LGSLPCLMLLDLSHNALETLELGA-RALGSLRTLLLQGNALRDLPPYTFANLASLQRLNL 417
              L  L  L L  N +  +   +   L S+R L L  N +  + P  F  L SL  LNL
Sbjct: 602 FKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNL 661

Query: 418 QGNRVS-----------------PCGGPD-------EPGPSGCVAFSGITSLRSLSLVDN 453
             N  +                   G P        +  P   VA    T        DN
Sbjct: 662 LANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGND--DN 719

Query: 454 EIELLRAGAFLHTPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVDLPCF 513
               L       T L  +   SN GL+V      G+   +  L L GN   ++  +L  +
Sbjct: 720 SCSPLSRCPTECTCLDTVVRCSNKGLKVLP---KGIPRDVTELYLDGNQFTLVPKELSNY 776

Query: 514 ICLKRLNLAENRLSHL--PAWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRLYLQGN 571
             L  ++L+ NR+S L   +++    L  L L  N    +P     GL+ SLR L L GN
Sbjct: 777 KHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLK-SLRLLSLHGN 835

Query: 572 PLSCCGNG 579
            +S    G
Sbjct: 836 DISVVPEG 843



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 103/428 (24%), Positives = 173/428 (40%), Gaps = 65/428 (15%)

Query: 32  KVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQP- 90
           K+S      L  P     +  T+D S  +L  I    +  YTA   L L+ NE + L+  
Sbjct: 495 KLSGDCFADLACPEKCRCEGTTVDCSNQKLNKI-PEHIPQYTA--ELRLNNNEFTVLEAT 551

Query: 91  GAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPS 150
           G F+ L  L  ++ ++N++   T +  G       V  + L+ N L   +  ++     S
Sbjct: 552 GIFKKLPQLRKINFSNNKI---TDIEEGAFEGASGVNEILLTSNRL-ENVQHKMFKGLES 607

Query: 151 LHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRN--S 208
           L TL L  N +T +   +F  + ++  L L+ N +  +  GAF+ L  L+ LNL  N  +
Sbjct: 608 LKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFN 667

Query: 209 LTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPDLAALPRLI 268
             C   +  + LR   +   +          Q  + L  + +++  +  F          
Sbjct: 668 CNCYLAWLGEWLRKKRIVTGNPRC-------QKPYFLKEIPIQDVAIQDFTCDDGNDD-- 718

Query: 269 YLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIE 328
             N  + L R PT        +   ++G   LP   P           +  L L  N+  
Sbjct: 719 --NSCSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPR---------DVTELYLDGNQFT 767

Query: 329 LIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGARA-LGS 387
           L+P                         + L +   L L+DLS+N + TL   + + +  
Sbjct: 768 LVP-------------------------KELSNYKHLTLIDLSNNRISTLSNQSFSNMTQ 802

Query: 388 LRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRS 447
           L TL+L  N LR +PP TF  L SL+ L+L GN +S         P G  AF+ +++L  
Sbjct: 803 LLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVV-------PEG--AFNDLSALSH 853

Query: 448 LSLVDNEI 455
           L++  N +
Sbjct: 854 LAIGANPL 861



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 45/136 (33%), Positives = 63/136 (46%), Gaps = 5/136 (3%)

Query: 26  CKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEI 85
           C  +D  V C   GL  +P  +P D   L L GNQ  +++   L  Y  L  +DLS N I
Sbjct: 731 CTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQF-TLVPKELSNYKHLTLIDLSNNRI 789

Query: 86  SFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLL 145
           S L   +F  +T L  L L++NRL      +  GL  L     L L GN + S + E   
Sbjct: 790 STLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSL---RLLSLHGNDI-SVVPEGAF 845

Query: 146 GEAPSLHTLSLAENSL 161
            +  +L  L++  N L
Sbjct: 846 NDLSALSHLAIGANPL 861



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 60/203 (29%), Positives = 90/203 (44%), Gaps = 19/203 (9%)

Query: 390 TLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLS 449
           T+   G ALR +P     N    +RL+L GN ++     D         F+G+  LR L 
Sbjct: 38  TVDCHGLALRSVPRNIPRNT---ERLDLNGNNITRITKTD---------FAGLRHLRVLQ 85

Query: 450 LVDNEIELLRAGAFLH-TPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVL-Q 507
           L++N+I  +  GAF     L  L L+ N  L++    L    A L  L L  N +  + +
Sbjct: 86  LMENKISTIERGAFQDLKELERLRLNRN-HLQLFPELLFLGTAKLYRLDLSENQIQAIPR 144

Query: 508 VDLPCFICLKRLNLAENRLSHLP--AWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRR 565
                 + +K L L  N++S +   A+     LEVL L NN+ + L  ++   +   LR 
Sbjct: 145 KAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHM-PKLRT 203

Query: 566 LYLQGNPLSC-CGNGWLAAQLHQ 587
             L  N L C C   WL+  L Q
Sbjct: 204 FRLHSNNLYCDCHLAWLSDWLRQ 226


>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
           [Homo sapiens]
          Length = 1093

 Score =  115 bits (289), Expect = 1e-25
 Identities = 134/458 (29%), Positives = 196/458 (42%), Gaps = 90/458 (19%)

Query: 2   RPQILLLLALLTLGL---AAQHQDKVPCKMV----DKKVSCQVLGLLQVPSVLPPDTETL 54
           R   LLLL LL L L    A    + PC          + C   GL  +P  LP  T +L
Sbjct: 14  RSPCLLLLWLLLLRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLAALPGDLPSWTRSL 73

Query: 55  DLSGNQLRSILASPLGFYTA--LRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMA 112
           +LS N+L  I   P GF     L+ + L+ NE++ + P    A +H+  L L HN++   
Sbjct: 74  NLSYNKLSEI--DPAGFEDLPNLQEVYLNNNELTAV-PSLGAASSHVVSLFLQHNKIRSV 130

Query: 113 TA-------------LSAGGLGPL--------PRVTSLDLSGNSLYSGLLERLLGEAPSL 151
                          LS   +  +        P +  L+L+GN + +  L    G + SL
Sbjct: 131 EGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSL 190

Query: 152 HTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTC 211
            TL L++N +T+L    F+ +P L QLDL+ N +  IE   F+GL  L  L L RN+++ 
Sbjct: 191 LTLRLSKNRITQLPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISK 249

Query: 212 ISD---FSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPDLAALPRLI 268
           ++D   + L ++ VL L  NS+    + S                       L  L  L 
Sbjct: 250 LTDGAFWGLSKMHVLHLEYNSLVEVNSGS-----------------------LYGLTALH 286

Query: 269 YLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIE 328
            L+LSNN I            IH   +GWS                 +L  L LS+N + 
Sbjct: 287 QLHLSNNSIAR----------IHR--KGWSFC--------------QKLHELVLSFNNLT 320

Query: 329 LIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALE-TLELGARA--- 384
            + +  L  L+SL  L LS N +          L  L +LDL HN +  T+E  + A   
Sbjct: 321 RLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSG 380

Query: 385 LGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRV 422
           L SL  L L GN ++ +    F+ L  L+ LNL GN +
Sbjct: 381 LDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAI 418



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 82/311 (26%), Positives = 127/311 (40%), Gaps = 45/311 (14%)

Query: 344 LNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPP 403
           LNLS N L   +      LP L  + L++N L  +     A   + +L LQ N +R +  
Sbjct: 73  LNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLQHNKIRSVEG 132

Query: 404 YTFANLASLQRLNLQGNRVS-------PCGGP--------DEPGPSGCVAFSGIT-SLRS 447
                  SL+ L+L  N ++       P G P        +  G     AF G++ SL +
Sbjct: 133 SQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLT 192

Query: 448 LSLVDNEIELLRAGAFLHTPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQ 507
           L L  N I  L   AF    LT+LDL+ N    +      GL  SLEVL LQ N +    
Sbjct: 193 LRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLN-SLEVLKLQRNNI---- 247

Query: 508 VDLPCFICLKRLNLAENRLSHLPAWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRLY 567
                           ++L+    W  +  + VL L  NS   +   ++ GL T+L +L+
Sbjct: 248 ----------------SKLTDGAFWGLS-KMHVLHLEYNSLVEVNSGSLYGL-TALHQLH 289

Query: 568 LQGNPLS-CCGNGWLAAQ-LHQGRVDVD----ATQDLICRFSSQEEVSLSHVRPEDCEKG 621
           L  N ++     GW   Q LH+  +  +      ++ +   SS   + LSH       +G
Sbjct: 290 LSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEG 349

Query: 622 GLKNINLIIIL 632
             K +  + +L
Sbjct: 350 AFKGLRSLRVL 360



 Score = 30.0 bits (66), Expect = 7.1
 Identities = 16/52 (30%), Positives = 27/52 (51%)

Query: 54  LDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLA 105
           L L GN+++S+          L HL+L  N I  +Q  AF  + +L+ L ++
Sbjct: 387 LTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELHIS 438


>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
           sapiens]
          Length = 593

 Score =  115 bits (288), Expect = 1e-25
 Identities = 127/404 (31%), Positives = 171/404 (42%), Gaps = 71/404 (17%)

Query: 6   LLLLALLTLGLAAQHQDKVPCKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSIL 65
           LL L LL  G          C    + V C    L  VP  LP DTE LDLSGN+L  + 
Sbjct: 17  LLFLLLLPGGSGGSCPAVCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQ 76

Query: 66  ASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPR 125
              L   + L+ LDLS N++S L+PGAF  L  L  L L  NRL                
Sbjct: 77  QGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLR--------------- 121

Query: 126 VTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVL 185
                + G  ++SGL         +L  L L  N +       F ++ +L++L++  N L
Sbjct: 122 -----IMGPGVFSGL--------SALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHL 168

Query: 186 MDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQ--------QLRVLDLSCNSIEAFQTAS 237
           + +  GAF GL +L+ L L R +L+ +   +L         +LR LD+      A +   
Sbjct: 169 VFVAPGAFAGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLG 228

Query: 238 QPQAEFQLTWLDLRENKLLHFPDLAALP--RLIYLNLSNNLIRLPTGPPQDSKGIHAPSE 295
           Q           L+E ++  +P L AL    L+ LNLS+  I                  
Sbjct: 229 Q-----------LKELEIHLWPSLEALDPGSLVGLNLSSLAI---------------TRC 262

Query: 296 GWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFE 355
             S++P  A         LS L  LDLS N I  IP   L  L  L  L LS  CL +  
Sbjct: 263 NLSSVPFQAL------YHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIA 316

Query: 356 ARRLGSLPCLMLLDLSHNALETLELGA-RALGSLRTLLLQGNAL 398
           A     L    LLD++ NAL+TLE  A  +   L TL L GN L
Sbjct: 317 AHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPL 360



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 106/365 (29%), Positives = 139/365 (38%), Gaps = 69/365 (18%)

Query: 121 GPLPRVTSL-DLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLD 179
           G LP  T L DLSGN L+ GL + +L     L  L L+ N L+ L    F  + +L  L 
Sbjct: 56  GGLPLDTELLDLSGNRLW-GLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLR 114

Query: 180 LHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFS---LQQLRVLDLSCNSIEAFQTA 236
           L  N L  +  G F GL  LT L+L  N +    D +   L  L+ L++  N +  F   
Sbjct: 115 LQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHL-VFVAP 173

Query: 237 SQPQAEFQLTWLDLRENKLLHFPDLAA--LPRLIYLNLSN-NLIRLPTGPPQDSKGIHAP 293
                  +L+ L L    L   P LA   LP L+ L L   ++ RLP G           
Sbjct: 174 GAFAGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAG----------- 222

Query: 294 SEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRT 353
                           + R L QL  L     EI L P        SL  LNLS   +  
Sbjct: 223 ----------------ALRGLGQLKEL-----EIHLWPSLEALDPGSLVGLNLSSLAITR 261

Query: 354 FEARRLGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQ 413
                L S+P   L  LS                LR L L  N +  +P    + L  LQ
Sbjct: 262 CN---LSSVPFQALYHLSF---------------LRVLDLSQNPISAIPARRLSPLVRLQ 303

Query: 414 RLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAF-LHTPLTELD 472
            L L G  ++              AF G+T+   L + DN ++ L   AF     L  L 
Sbjct: 304 ELRLSGACLTSIAAH---------AFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLR 354

Query: 473 LSSNP 477
           LS NP
Sbjct: 355 LSGNP 359



 Score = 36.2 bits (82), Expect = 0.099
 Identities = 35/93 (37%), Positives = 40/93 (43%), Gaps = 22/93 (23%)

Query: 487 GGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEVLDLRNN 546
           GGL    E+L L GN L  LQ  +     L RL+L                L+ LDL  N
Sbjct: 56  GGLPLDTELLDLSGNRLWGLQQGM-----LSRLSL----------------LQELDLSYN 94

Query: 547 SFSLLPGSAMGGLETSLRRLYLQGNPLSCCGNG 579
             S L   A  GL+ SL  L LQGN L   G G
Sbjct: 95  QLSTLEPGAFHGLQ-SLLTLRLQGNRLRIMGPG 126



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 33/97 (34%), Positives = 48/97 (49%), Gaps = 8/97 (8%)

Query: 468 LTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLS 527
           L ELDLS N    +  GA  GL+ SL  L LQGN L ++   +  F  L  L L + RL+
Sbjct: 86  LQELDLSYNQLSTLEPGAFHGLQ-SLLTLRLQGNRLRIMGPGV--FSGLSALTLLDLRLN 142

Query: 528 HL-----PAWTQAVSLEVLDLRNNSFSLLPGSAMGGL 559
            +      A+ +  SL+ L++ +N    +   A  GL
Sbjct: 143 QIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGL 179


>gi|4504379 leucine-rich repeat-containing G protein-coupled
           receptor 5 [Homo sapiens]
          Length = 907

 Score =  114 bits (284), Expect = 4e-25
 Identities = 121/408 (29%), Positives = 184/408 (45%), Gaps = 37/408 (9%)

Query: 32  KVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPG 91
           +V C  LGL ++PS L   T  LDLS N +  +L +PL     L  L L+ N ++++  G
Sbjct: 49  RVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKG 108

Query: 92  AFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGN-------SLYSGLLERL 144
           AF  L  L+ L L +N+L     +    L  L  + SL L  N       S +SGL    
Sbjct: 109 AFTGLYSLKVLMLQNNQL---RHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGL---- 161

Query: 145 LGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNL 204
                SL  L L +N+LT +    FR + AL+ + L  N +  I D AF  L  L  L+L
Sbjct: 162 ----HSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHL 217

Query: 205 SRNSLTCISD---FSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPDL 261
             N +  +       L  L  LDL+ N+++ F TA +  +   L  L    N +   P+ 
Sbjct: 218 HNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLS--NLKELGFHSNNIRSIPEK 275

Query: 262 AAL--PRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLN 319
           A +  P LI ++  +N I+        S   H P      L L+  S       L+   N
Sbjct: 276 AFVGNPSLITIHFYDNPIQF----VGRSAFQHLPE--LRTLTLNGASQITEFPDLTGTAN 329

Query: 320 LD---LSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALE 376
           L+   L+  +I  +P +    L +L  L+LS N L    +        L  +DL HN + 
Sbjct: 330 LESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPS--FSVCQKLQKIDLRHNEIY 387

Query: 377 TLELGA-RALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVS 423
            +++   + L SLR+L L  N +  + P  F+ L SL +L+L  N +S
Sbjct: 388 EIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLS 435



 Score = 82.8 bits (203), Expect = 9e-16
 Identities = 112/406 (27%), Positives = 171/406 (42%), Gaps = 55/406 (13%)

Query: 200 THLNLSRNSLTCISDFSLQQLRVLD---LSCNSIEAFQTASQPQAEFQLTWLDLRENKLL 256
           ++L+LS N+++ +    L  LR L+   L+ N++      +     + L  L L+ N+L 
Sbjct: 69  SYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGL-YSLKVLMLQNNQLR 127

Query: 257 HFPD--LAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGW------SALPLSAPSGN 308
           H P   L  L  L  L L  N I     PP    G+H+    W      + +P+ A    
Sbjct: 128 HVPTEALQNLRSLQSLRLDANHISYV--PPSCFSGLHSLRHLWLDDNALTEIPVQA---- 181

Query: 309 ASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLL 368
              R LS L  + L+ N+I  IPD    +L+SL  L+L  N + +   +    L  L  L
Sbjct: 182 --FRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETL 239

Query: 369 DLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGP 428
           DL++N L+      R L +L+ L    N +R +P   F    SL  ++   N +   G  
Sbjct: 240 DLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRS 299

Query: 429 -----------DEPGPSGCVAF---SGITSLRSLSLVDNEIELLRAGAFLHTP-LTELDL 473
                         G S    F   +G  +L SL+L   +I  L        P L  LDL
Sbjct: 300 AFQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDL 359

Query: 474 SSN-----PGLEVATGALGGLEASLEVLALQGNGLMVLQVD-LPCFICLKRLNLAENRLS 527
           S N     P   V           L+ + L+ N +  ++VD     + L+ LNLA N+++
Sbjct: 360 SYNLLEDLPSFSVC--------QKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIA 411

Query: 528 --HLPAWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRLYLQGN 571
             H  A++   SL  LDL +N  S  P + + G    L  L L GN
Sbjct: 412 IIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHG----LTHLKLTGN 453



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 50/179 (27%), Positives = 84/179 (46%), Gaps = 12/179 (6%)

Query: 49  PDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNR 108
           P+  TL L+G    +      G    L  L L+  +IS L       L +L+ L L++N 
Sbjct: 305 PELRTLTLNGASQITEFPDLTGTAN-LESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNL 363

Query: 109 LAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHT 168
           L    + S        ++  +DL  N +Y   ++    +  SL +L+LA N +  +  + 
Sbjct: 364 LEDLPSFSV-----CQKLQKIDLRHNEIYEIKVDTFQ-QLLSLRSLNLAWNKIAIIHPNA 417

Query: 169 FRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSL--TCISDFSLQQLRVLDL 225
           F  +P+L +LDL SN+L         GL  LTHL L+ N    + IS  +  +L+V+++
Sbjct: 418 FSTLPSLIKLDLSSNLLSSF---PITGLHGLTHLKLTGNHALQSLISSENFPELKVIEM 473


>gi|157694513 leucine-rich repeat-containing G protein-coupled
           receptor 4 [Homo sapiens]
          Length = 951

 Score =  113 bits (283), Expect = 5e-25
 Identities = 145/514 (28%), Positives = 203/514 (39%), Gaps = 85/514 (16%)

Query: 3   PQILLLLALLTLGL--------AAQHQDKVPCKMV-DKKVSCQVLGLLQVPSVLPPDTET 53
           P  L LL  L LGL        AA      PC    D++V C   GL  VP  L   T+ 
Sbjct: 2   PGPLGLLCFLALGLLGSAGPSGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQA 61

Query: 54  LDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMAT 113
           LD+S N +  +       +  L  L L+ N++SF+ P A   L  L+ L+L +N+L    
Sbjct: 62  LDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVP 121

Query: 114 ALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMP 173
           + +  GL  L    SL L  N + S   +   G     H L L +NSLT +  H   ++P
Sbjct: 122 SEAIRGLSAL---QSLRLDANHITSVPEDSFEGLVQLRH-LWLDDNSLTEVPVHPLSNLP 177

Query: 174 ALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDF---SLQQLRVLDLSCNSI 230
            L+ L L  N +  I D AF  L  L  L+L  N +  +S      L  L  LDL+ N++
Sbjct: 178 TLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNL 237

Query: 231 EAFQTASQPQAEFQLTWLDLRENKLLHFPDLA----ALPRLIYL--------------NL 272
             F  A   +A   L  L    N +   PD A     L R I+L              NL
Sbjct: 238 GEFPQAI--KALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNL 295

Query: 273 SNNLIRLPTGP------PQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNE 326
           S+    +  G       P  +  +H  S   +   +S+   N   +    L  LDLSYN 
Sbjct: 296 SDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLC-QEQKMLRTLDLSYNN 354

Query: 327 IELIP----------------------DSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPC 364
           I  +P                      +   + L SL  L+LSRN +    +R   +L  
Sbjct: 355 IRDLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGP 414

Query: 365 LMLLDLSHNALETLELGARALGSLRTLLLQGN-ALRD-LPPYTFANLASLQRLNLQGNRV 422
           +  LD+S N L +       L  L  L L GN  L++ L    F NL SL          
Sbjct: 415 ITNLDVSFNELTSFP--TEGLNGLNQLKLVGNFKLKEALAAKDFVNLRSL---------- 462

Query: 423 SPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIE 456
                   P    C AF G  S  +L+  DN ++
Sbjct: 463 ------SVPYAYQCCAFWGCDSYANLNTEDNSLQ 490



 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 95/357 (26%), Positives = 141/357 (39%), Gaps = 44/357 (12%)

Query: 202 LNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKL--LHFP 259
           ++ S   LT + +      + LD+S N+I      +     F L  L L  N L  +H  
Sbjct: 41  VDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPF-LEELQLAGNDLSFIHPK 99

Query: 260 DLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLN 319
            L+ L  L  L L NN  +L T P +  +G                        LS L +
Sbjct: 100 ALSGLKELKVLTLQNN--QLKTVPSEAIRG------------------------LSALQS 133

Query: 320 LDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETL- 378
           L L  N I  +P+   E L  L  L L  N L       L +LP L  L L+ N + ++ 
Sbjct: 134 LRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIP 193

Query: 379 ELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVA 438
           +     L SL  L L  N +R L  + F  L +L+ L+L  N +               A
Sbjct: 194 DFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQ----------A 243

Query: 439 FSGITSLRSLSLVDNEIELLRAGAFLHTPLTE-LDLSSNPGLEVATGALGGLEASLEVLA 497
              + SL+ L    N I ++  GAF   PL   + L  NP   V   A   L + L  L 
Sbjct: 244 IKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNL-SDLHSLV 302

Query: 498 LQGNGLMVLQVDLPCFICLKRLNLAENRLSHLP--AWTQAVSLEVLDLRNNSFSLLP 552
           ++G  ++    +L   + L+ L L   ++S +P     +   L  LDL  N+   LP
Sbjct: 303 IRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLP 359



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 75/264 (28%), Positives = 116/264 (43%), Gaps = 41/264 (15%)

Query: 320 LDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLE 379
           LD+S N I  +P+   ++   L  L L+ N L     + L  L  L +L L +N L+T+ 
Sbjct: 62  LDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVP 121

Query: 380 LGA-RALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVA 438
             A R L +L++L L  N +  +P  +F  L  L+ L L  N ++    P  P       
Sbjct: 122 SEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEV--PVHP------- 172

Query: 439 FSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPGLEVATGALGGLEASLEVLAL 498
            S + +L++L+L  N+I  +   AF +                         +SL VL L
Sbjct: 173 LSNLPTLQALTLALNKISSIPDFAFTNL------------------------SSLVVLHL 208

Query: 499 QGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAV----SLEVLDLRNNSFSLLPGS 554
             N +  L     CF  L  L   +   ++L  + QA+    SL+ L   +NS S++P  
Sbjct: 209 HNNKIRSLSQH--CFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIPDG 266

Query: 555 AMGGLETSLRRLYLQGNPLSCCGN 578
           A  G    LR ++L  NPLS  GN
Sbjct: 267 AFDG-NPLLRTIHLYDNPLSFVGN 289



 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 63/210 (30%), Positives = 90/210 (42%), Gaps = 17/210 (8%)

Query: 368 LDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGG 427
           +D S   L  +  G  A    + L +  N +  LP   F N   L+ L L GN +S    
Sbjct: 41  VDCSGKGLTAVPEGLSAF--TQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHP 98

Query: 428 PDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLH-TPLTELDLSSNPGLEVATGAL 486
                     A SG+  L+ L+L +N+++ + + A    + L  L L +N    V   + 
Sbjct: 99  K---------ALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSF 149

Query: 487 GGLEASLEVLALQGNGLMVLQVD-LPCFICLKRLNLAENRLSHLP--AWTQAVSLEVLDL 543
            GL   L  L L  N L  + V  L     L+ L LA N++S +P  A+T   SL VL L
Sbjct: 150 EGL-VQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHL 208

Query: 544 RNNSFSLLPGSAMGGLETSLRRLYLQGNPL 573
            NN    L      GL+ +L  L L  N L
Sbjct: 209 HNNKIRSLSQHCFDGLD-NLETLDLNYNNL 237


>gi|45505137 podocan [Homo sapiens]
          Length = 661

 Score =  112 bits (281), Expect = 8e-25
 Identities = 160/557 (28%), Positives = 224/557 (40%), Gaps = 92/557 (16%)

Query: 33  VSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISF--LQP 90
           V C  + L + P  LP  T  L L  NQL  I    L     L  L+L  N ++   L  
Sbjct: 128 VDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPE 187

Query: 91  GAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPS 150
            AF+ LT+L +L LA+N+L +A          LP                         +
Sbjct: 188 KAFEHLTNLNYLYLANNKLTLAPRF-------LPN------------------------A 216

Query: 151 LHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMD--IEDGAFEGLPRLTHLNLSRNS 208
           L ++  A N LT++   TF   P L  + LH+N L D  + D  F G   +  L LS N 
Sbjct: 217 LISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNF 276

Query: 209 LTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKL----LHFPDLAAL 264
           L  +       L  L L  N +E     +  +    L  L L+ N L    L       L
Sbjct: 277 LRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELS-SLRELYLQNNYLTDEGLDNETFWKL 335

Query: 265 PRLIYLNLS-NNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLS 323
             L YL+LS NNL R+P G P+                               L+ L L 
Sbjct: 336 SSLEYLDLSSNNLSRVPAGLPRS------------------------------LVLLHLE 365

Query: 324 YNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLG--SLPCLMLLDLSHNALETLELG 381
            N I  +  + L  + SL +L L  N LR      L    L  L  + L +NALE +  G
Sbjct: 366 KNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSG 425

Query: 382 ARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRV-SPCGGPDEPGPSGCVAFS 440
                 +RTL++  N +  +    FA    L+ LNL  NR+ SP    D        AF 
Sbjct: 426 LPR--RVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRD--------AFR 475

Query: 441 GITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPGLEVATGALGGLEASLEVLALQG 500
            +  LRSL L  N +  L  G  L   +  L +  N    +A GAL G+ A L  L L  
Sbjct: 476 KLRLLRSLDLSGNRLHTLPPG--LPRNVHVLKVKRNELAALARGALVGM-AQLRELYLTS 532

Query: 501 NGLMVLQVDLPCFICLKRLNL---AENRLSHLPAWTQAVSLEVLDLRNNSFSLLPGSAMG 557
           N L    +    ++ L  L L   A N+L+ +P      SLE L L+NN  S +P +A  
Sbjct: 533 NRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPE-SLEYLYLQNNKISAVPANAFD 591

Query: 558 GLETSLRRLYLQGNPLS 574
               +L+ ++L+ N L+
Sbjct: 592 S-TPNLKGIFLRFNKLA 607



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 64/216 (29%), Positives = 89/216 (41%), Gaps = 31/216 (14%)

Query: 40  LLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQP--GAFQALT 97
           L +VPS LP    TL +  NQ+  I          L  L+LS N I+  Q    AF+ L 
Sbjct: 419 LERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLR 478

Query: 98  HLEHLSLAHNRLAMA------------------TALSAGGLGPLPRVTSLDLSGNSLYSG 139
            L  L L+ NRL                      AL+ G L  + ++  L L+ N L S 
Sbjct: 479 LLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLRELYLTSNRLRSR 538

Query: 140 LL-ERLLGEAPSLHTLSLAENSLTRLTRHTFRDMP-ALEQLDLHSNVLMDIEDGAFEGLP 197
            L  R   +   L  L +A N LT +       +P +LE L L +N +  +   AF+  P
Sbjct: 539 ALGPRAWVDLAHLQLLDIAGNQLTEIPE----GLPESLEYLYLQNNKISAVPANAFDSTP 594

Query: 198 RLTHLNLSRNSLTCISDFS-----LQQLRVLDLSCN 228
            L  + L  N L   S        L+ L+VLD+  N
Sbjct: 595 NLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630


>gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
          Length = 620

 Score =  112 bits (280), Expect = 1e-24
 Identities = 114/403 (28%), Positives = 174/403 (43%), Gaps = 61/403 (15%)

Query: 2   RPQILLLLALLTLGLAAQHQDKVPCKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQL 61
           +P +LL+L  +  G A     +  C   D+ V C     + VP  +P +T  LDL  N++
Sbjct: 24  QPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRI 83

Query: 62  RSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLG 121
           +++       +  L  L+L+ N +S ++PGAF  L +L  L L  NRL +   +  G   
Sbjct: 84  KTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKL---IPLGVFT 140

Query: 122 PLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLH 181
            L  +T LD+S N +   LL+ +  +  +L +L + +N L  ++   F  + +LEQL L 
Sbjct: 141 GLSNLTKLDISENKIVI-LLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLE 199

Query: 182 SNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFS---LQQLRVLDLSCNSIEAFQTASQ 238
              L  I   A   L  L  L L   ++  I D+S   L +L+VL++S            
Sbjct: 200 KCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEIS------------ 247

Query: 239 PQAEFQLTWLDLRENKLLHFPDLAAL-PRLIY-LNLSNNLIRLPTGPPQDSKGIHAPSEG 296
                             H+P L  + P  +Y LNL++  I             H     
Sbjct: 248 ------------------HWPYLDTMTPNCLYGLNLTSLSI------------THC---N 274

Query: 297 WSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEA 356
            +A+P  A       R L  L  L+LSYN I  I  S L  L  L  + L    L   E 
Sbjct: 275 LTAVPYLAV------RHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEP 328

Query: 357 RRLGSLPCLMLLDLSHNALETLELGA-RALGSLRTLLLQGNAL 398
                L  L +L++S N L TLE     ++G+L TL+L  N L
Sbjct: 329 YAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPL 371



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 65/245 (26%), Positives = 109/245 (44%), Gaps = 24/245 (9%)

Query: 339 TSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGA-RALGSLRTLLLQGNA 397
           T    L+L +N ++T       S P L  L+L+ N +  +E GA   L +LRTL L+ N 
Sbjct: 71  TETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNR 130

Query: 398 LRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIEL 457
           L+ +P   F  L++L +L++  N++                F  + +L+SL + DN++  
Sbjct: 131 LKLIPLGVFTGLSNLTKLDISENKIVILLD---------YMFQDLYNLKSLEVGDNDLVY 181

Query: 458 LRAGAFLH-TPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVDLPCFICL 516
           +   AF     L +L L       + T AL  L     ++ L+   L +  +    F  L
Sbjct: 182 ISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHG---LIVLRLRHLNINAIRDYSFKRL 238

Query: 517 KRLNLAENRLSH-------LPAWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRLYLQ 569
            RL + E  +SH        P     ++L  L + + + + +P  A+  L   LR L L 
Sbjct: 239 YRLKVLE--ISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHL-VYLRFLNLS 295

Query: 570 GNPLS 574
            NP+S
Sbjct: 296 YNPIS 300


>gi|226342933 podocan-like 1 isoform 2 [Homo sapiens]
          Length = 510

 Score =  112 bits (279), Expect = 1e-24
 Identities = 140/451 (31%), Positives = 203/451 (45%), Gaps = 54/451 (11%)

Query: 26  CKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEI 85
           C  VD  V C  L L   P  +    + L L  NQL+ +  + L   + LR L+L  N I
Sbjct: 50  CPRVDT-VDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLI 108

Query: 86  SF--LQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPR-VTSLDLSGNSLYSGLLE 142
           S   L   AF++LT L+HL +AHN+L++A          LPR +   DL+ N +   +  
Sbjct: 109 SSEGLPDEAFESLTQLQHLCVAHNKLSVAPQF-------LPRSLRVADLAANQVME-IFP 160

Query: 143 RLLGEAPSLHTLSLAENSLTR--LTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLT 200
              GE P+L ++ L  N L+   L    FR   A+  L L +N L  +        P L 
Sbjct: 161 LTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSL---PPSLE 217

Query: 201 HLNLSRNSLTCISDFSLQ---QLRVLDLSCNSI-EAFQTASQPQAEFQLTWLDLRENKLL 256
            L+L  N ++ +   +L    QLR L L  N + ++   A+       L +LDL  N+L 
Sbjct: 218 RLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLT 277

Query: 257 HFPDLAALPR-LIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASG---- 311
             P  A LPR L  L+L  N IR       ++  +H  + G   L L      +SG    
Sbjct: 278 TVP--AGLPRTLAILHLGRNRIR-----QVEAARLHG-ARGLRYLLLQHNQLGSSGLPAG 329

Query: 312 --RPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLD 369
             RPL  L  L L  N ++ +P +    L +L    L  N +    AR L + P L  L+
Sbjct: 330 ALRPLRGLHTLHLYGNGLDRVPPALPRRLRALV---LPHNHVAALGARDLVATPGLTELN 386

Query: 370 LSHNALETLELGARA---LGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCG 426
           L++N L +  +  RA   L +LR+L L GN L  LP      L +LQ   LQ N++    
Sbjct: 387 LAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQ---LQRNQLRML- 442

Query: 427 GPDEPGPSGCVAFSGITSLRSLSLVDNEIEL 457
              EP P      +G+  LR LSL  N + +
Sbjct: 443 ---EPEP-----LAGLDQLRELSLAHNRLRV 465



 Score =  102 bits (253), Expect = 1e-21
 Identities = 135/438 (30%), Positives = 186/438 (42%), Gaps = 60/438 (13%)

Query: 124 PRVTSLDLSGNSLYSGLLERLLGE--APSLHTLSLAENSLTRLTRHTFRDMPALEQLDLH 181
           PRV ++D  G  L      R+  +    +   LSL  N L  L  +    +  L  L+LH
Sbjct: 51  PRVDTVDCDGLDL------RVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLH 104

Query: 182 SNVLMD--IEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSI-EAFQTASQ 238
           +N++    + D AFE L +L HL ++ N L+    F  + LRV DL+ N + E F     
Sbjct: 105 NNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFG 164

Query: 239 PQAEFQLTWLDLRENKLLHFPDLA--ALPRLIYLNLSNN-LIRLPTGPPQDSKGIHAPSE 295
            +   +  +L   +      P  A      +  L+LSNN L  LP   P   + +H  + 
Sbjct: 165 EKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNN 224

Query: 296 GWSALPLSAPSGNASGRPL----SQLLN----------------LDLSYNEIELIPDSFL 335
             S +P  A S     R L    +QL +                LDLS+N++  +P    
Sbjct: 225 LISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLP 284

Query: 336 EHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGARALGSLR---TLL 392
               +L  L+L RN +R  EA RL     L  L L HN L +  L A AL  LR   TL 
Sbjct: 285 R---TLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLH 341

Query: 393 LQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVD 452
           L GN L  +PP   A    L+ L L  N V+  G  D       VA  G+T    L+L  
Sbjct: 342 LYGNGLDRVPP---ALPRRLRALVLPHNHVAALGARD------LVATPGLT---ELNLAY 389

Query: 453 NEIELLRA--GAFLH-TPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVD 509
           N +   R    AF     L  LDL+ N      T    GL   L  L LQ N L +L+ +
Sbjct: 390 NRLASARVHHRAFRRLRALRSLDLAGNQ----LTRLPMGLPTGLRTLQLQRNQLRMLEPE 445

Query: 510 -LPCFICLKRLNLAENRL 526
            L     L+ L+LA NRL
Sbjct: 446 PLAGLDQLRELSLAHNRL 463



 Score = 63.9 bits (154), Expect = 4e-10
 Identities = 69/234 (29%), Positives = 98/234 (41%), Gaps = 49/234 (20%)

Query: 391 LLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSL 450
           L LQ N L++LP    + L+ L+ LNL  N +S  G PDE       AF  +T L+ L +
Sbjct: 77  LSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDE-------AFESLTQLQHLCV 129

Query: 451 VDNEIELLRAGAFLHTPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVDL 510
             N++ +  A  FL   L   DL++N  +E+     G   A                   
Sbjct: 130 AHNKLSV--APQFLPRSLRVADLAANQVMEIFPLTFGEKPA------------------- 168

Query: 511 PCFICLKRLNLAENRLSH--LP--AWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRL 566
                L+ + L  N+LS+  LP  A+  + ++  L L NN  S LP S    L  SL RL
Sbjct: 169 -----LRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPS----LPPSLERL 219

Query: 567 YLQGNPLSCCGNGWLAAQL--------HQGRVDVDATQDLICRFSSQEEVSLSH 612
           +LQ N +S    G L+ Q         H    D         +  S E + LSH
Sbjct: 220 HLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSH 273



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 30/70 (42%), Positives = 39/70 (55%), Gaps = 9/70 (12%)

Query: 53  TLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMA 112
           +LDL+GNQL  +   P+G  T LR L L  N++  L+P     L  L  LSLAHNRL + 
Sbjct: 410 SLDLAGNQLTRL---PMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRV- 465

Query: 113 TALSAGGLGP 122
                G +GP
Sbjct: 466 -----GDIGP 470



 Score = 35.0 bits (79), Expect = 0.22
 Identities = 24/71 (33%), Positives = 34/71 (47%), Gaps = 4/71 (5%)

Query: 40  LLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTN--EISFLQPGAFQALT 97
           L ++P  LP    TL L  NQLR +   PL     LR L L+ N   +  + PG +  L 
Sbjct: 418 LTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQ 477

Query: 98  HLE--HLSLAH 106
            L+  H  ++H
Sbjct: 478 ALQVRHRLVSH 488


>gi|226342931 podocan-like 1 isoform 1 [Homo sapiens]
          Length = 512

 Score =  112 bits (279), Expect = 1e-24
 Identities = 140/451 (31%), Positives = 203/451 (45%), Gaps = 54/451 (11%)

Query: 26  CKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEI 85
           C  VD  V C  L L   P  +    + L L  NQL+ +  + L   + LR L+L  N I
Sbjct: 52  CPRVDT-VDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLI 110

Query: 86  SF--LQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPR-VTSLDLSGNSLYSGLLE 142
           S   L   AF++LT L+HL +AHN+L++A          LPR +   DL+ N +   +  
Sbjct: 111 SSEGLPDEAFESLTQLQHLCVAHNKLSVAPQF-------LPRSLRVADLAANQVME-IFP 162

Query: 143 RLLGEAPSLHTLSLAENSLTR--LTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLT 200
              GE P+L ++ L  N L+   L    FR   A+  L L +N L  +        P L 
Sbjct: 163 LTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSL---PPSLE 219

Query: 201 HLNLSRNSLTCISDFSLQ---QLRVLDLSCNSI-EAFQTASQPQAEFQLTWLDLRENKLL 256
            L+L  N ++ +   +L    QLR L L  N + ++   A+       L +LDL  N+L 
Sbjct: 220 RLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLT 279

Query: 257 HFPDLAALPR-LIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASG---- 311
             P  A LPR L  L+L  N IR       ++  +H  + G   L L      +SG    
Sbjct: 280 TVP--AGLPRTLAILHLGRNRIR-----QVEAARLHG-ARGLRYLLLQHNQLGSSGLPAG 331

Query: 312 --RPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLD 369
             RPL  L  L L  N ++ +P +    L +L    L  N +    AR L + P L  L+
Sbjct: 332 ALRPLRGLHTLHLYGNGLDRVPPALPRRLRALV---LPHNHVAALGARDLVATPGLTELN 388

Query: 370 LSHNALETLELGARA---LGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCG 426
           L++N L +  +  RA   L +LR+L L GN L  LP      L +LQ   LQ N++    
Sbjct: 389 LAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQ---LQRNQLRML- 444

Query: 427 GPDEPGPSGCVAFSGITSLRSLSLVDNEIEL 457
              EP P      +G+  LR LSL  N + +
Sbjct: 445 ---EPEP-----LAGLDQLRELSLAHNRLRV 467



 Score =  102 bits (253), Expect = 1e-21
 Identities = 135/438 (30%), Positives = 186/438 (42%), Gaps = 60/438 (13%)

Query: 124 PRVTSLDLSGNSLYSGLLERLLGE--APSLHTLSLAENSLTRLTRHTFRDMPALEQLDLH 181
           PRV ++D  G  L      R+  +    +   LSL  N L  L  +    +  L  L+LH
Sbjct: 53  PRVDTVDCDGLDL------RVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLH 106

Query: 182 SNVLMD--IEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSI-EAFQTASQ 238
           +N++    + D AFE L +L HL ++ N L+    F  + LRV DL+ N + E F     
Sbjct: 107 NNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFG 166

Query: 239 PQAEFQLTWLDLRENKLLHFPDLA--ALPRLIYLNLSNN-LIRLPTGPPQDSKGIHAPSE 295
            +   +  +L   +      P  A      +  L+LSNN L  LP   P   + +H  + 
Sbjct: 167 EKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNN 226

Query: 296 GWSALPLSAPSGNASGRPL----SQLLN----------------LDLSYNEIELIPDSFL 335
             S +P  A S     R L    +QL +                LDLS+N++  +P    
Sbjct: 227 LISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLP 286

Query: 336 EHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGARALGSLR---TLL 392
               +L  L+L RN +R  EA RL     L  L L HN L +  L A AL  LR   TL 
Sbjct: 287 R---TLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLH 343

Query: 393 LQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVD 452
           L GN L  +PP   A    L+ L L  N V+  G  D       VA  G+T    L+L  
Sbjct: 344 LYGNGLDRVPP---ALPRRLRALVLPHNHVAALGARD------LVATPGLT---ELNLAY 391

Query: 453 NEIELLRA--GAFLH-TPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVD 509
           N +   R    AF     L  LDL+ N      T    GL   L  L LQ N L +L+ +
Sbjct: 392 NRLASARVHHRAFRRLRALRSLDLAGNQ----LTRLPMGLPTGLRTLQLQRNQLRMLEPE 447

Query: 510 -LPCFICLKRLNLAENRL 526
            L     L+ L+LA NRL
Sbjct: 448 PLAGLDQLRELSLAHNRL 465



 Score = 63.9 bits (154), Expect = 4e-10
 Identities = 69/234 (29%), Positives = 98/234 (41%), Gaps = 49/234 (20%)

Query: 391 LLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSL 450
           L LQ N L++LP    + L+ L+ LNL  N +S  G PDE       AF  +T L+ L +
Sbjct: 79  LSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDE-------AFESLTQLQHLCV 131

Query: 451 VDNEIELLRAGAFLHTPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVDL 510
             N++ +  A  FL   L   DL++N  +E+     G   A                   
Sbjct: 132 AHNKLSV--APQFLPRSLRVADLAANQVMEIFPLTFGEKPA------------------- 170

Query: 511 PCFICLKRLNLAENRLSH--LP--AWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRL 566
                L+ + L  N+LS+  LP  A+  + ++  L L NN  S LP S    L  SL RL
Sbjct: 171 -----LRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPS----LPPSLERL 221

Query: 567 YLQGNPLSCCGNGWLAAQL--------HQGRVDVDATQDLICRFSSQEEVSLSH 612
           +LQ N +S    G L+ Q         H    D         +  S E + LSH
Sbjct: 222 HLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSH 275



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 30/70 (42%), Positives = 39/70 (55%), Gaps = 9/70 (12%)

Query: 53  TLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMA 112
           +LDL+GNQL  +   P+G  T LR L L  N++  L+P     L  L  LSLAHNRL + 
Sbjct: 412 SLDLAGNQLTRL---PMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRV- 467

Query: 113 TALSAGGLGP 122
                G +GP
Sbjct: 468 -----GDIGP 472



 Score = 35.0 bits (79), Expect = 0.22
 Identities = 24/71 (33%), Positives = 34/71 (47%), Gaps = 4/71 (5%)

Query: 40  LLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTN--EISFLQPGAFQALT 97
           L ++P  LP    TL L  NQLR +   PL     LR L L+ N   +  + PG +  L 
Sbjct: 420 LTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQ 479

Query: 98  HLE--HLSLAH 106
            L+  H  ++H
Sbjct: 480 ALQVRHRLVSH 490


>gi|20302168 toll-like receptor 8 [Homo sapiens]
          Length = 1041

 Score =  110 bits (276), Expect = 3e-24
 Identities = 191/731 (26%), Positives = 292/731 (39%), Gaps = 143/731 (19%)

Query: 40  LLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTN-------EISFLQPGA 92
           L Q+PS LP     L L  N + +I    +     L++L L+ N       E + ++ G 
Sbjct: 137 LPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGV 196

Query: 93  FQALTHLEHLSLAHNRLAMATA------------------LSAGGLGPLPRVTSLDLSGN 134
           F+ LT+LE LSL+ N L+                      +S      L  +T LDLSGN
Sbjct: 197 FETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGN 256

Query: 135 SLY---------------SGLLERLLGE-APSLHTLSLAENSLTRLTRHTFRDMPALEQL 178
                             S  ++R   +    L  L+L+  SL ++    F++MP L+ L
Sbjct: 257 CPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVL 316

Query: 179 DLHSNVLM-DIEDGAF-EGLPRLTHLNLSRN----SLTCISDFSLQQLRVLDLSCNSIEA 232
           DL  N L+ +I  GAF   LPRL  L+LS N    S     + S    ++L L    +  
Sbjct: 317 DLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRG 376

Query: 233 FQTASQPQAEFQ-------LTWLDLREN--KLLHFPDLAALPRLIYLNLSNNLIRLPTGP 283
           +      + +FQ       L+ ++L  N  K + F        L  + LS N I   +  
Sbjct: 377 YVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRI---SPL 433

Query: 284 PQDSKGIHAPSEGWS----------------------ALPLSAPSGNASGRPLSQLLNLD 321
            +D++  +A S  +                         PL  P   A G+ L      D
Sbjct: 434 VKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKAL------D 487

Query: 322 LSYNEIELIPDSFLEHLTSLCFLNLSRNC-LRTFEARRLGSLPCLMLLDLSHNAL----- 375
           LS N I  I  +  E+L  +  LNLS N   +        ++P +  LDL++N L     
Sbjct: 488 LSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNA 547

Query: 376 ---------ETLELGARA-----------------LGSLRTLLLQGNALRDLPPYTFANL 409
                    E L+L   +                   +L+ L L  N +  L        
Sbjct: 548 SALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLES 607

Query: 410 ASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTP-- 467
            SL  L   GNR+      D+        F G+ +L  L L  N ++ +   AFL+ P  
Sbjct: 608 KSLVELVFSGNRLDILWNDDDNRYISI--FKGLKNLTRLDLSLNRLKHIPNEAFLNLPAS 665

Query: 468 LTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVDLPCFIC-LKRLNLAENRL 526
           LTEL ++ N  L+     L      LE+L L+GN L+ L   L  F   L+ L L+ NR+
Sbjct: 666 LTELHINDNM-LKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRI 724

Query: 527 SHLPA--WTQAVSLEVLDLRNNSFSLLPGSAM-GGLETSLRRLYLQGNPLSC-CGNG--- 579
           SHLP+   ++  SL+ LDL +N    +  SA+     T L  L L GNP  C C  G   
Sbjct: 725 SHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGDFR 784

Query: 580 -WLAAQLHQGRVDVDATQDLICRF-SSQEEVSLSHVRPEDCEKGGLKNINLIII--LTFI 635
            W+   L+   V +    D+IC     Q   S+  +    C    + ++  +I+   TF 
Sbjct: 785 RWMDEHLN---VKIPRLVDVICASPGDQRGKSIVSLELTTC----VSDVTAVILFFFTFF 837

Query: 636 LVSAILLTTLA 646
           + + ++L  LA
Sbjct: 838 ITTMVMLAALA 848



 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 140/551 (25%), Positives = 219/551 (39%), Gaps = 81/551 (14%)

Query: 50  DTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRL 109
           D+   + S  +L+ +    +G Y     LDLS N I+ +   +FQ L +L  ++L HN  
Sbjct: 43  DSVIAECSNRRLQEV-PQTVGKYVT--ELDLSDNFITHITNESFQGLQNLTKINLNHNPN 99

Query: 110 AM-----------ATALSAGGLGPLPRVTSLDLSGNSLY---SGLLERLLGEAPSLHTLS 155
                           ++ G    L  +  L L  N L    SGL E       SL  LS
Sbjct: 100 VQHQNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPE-------SLTELS 152

Query: 156 LAENSLTRLTRHTFRDMPALEQLDLHSNVLMD-------IEDGAFEGLPRLTHLNLSRNS 208
           L +N++  +T+     +  L+ L L  N   +       IEDG FE L  L  L+LS NS
Sbjct: 153 LIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNS 212

Query: 209 LTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLREN--KLLHFP------- 259
           L+ +       LR L LS   I+ + +    +    LT LDL  N  +  + P       
Sbjct: 213 LSHVPPKLPSSLRKLFLSNTQIK-YISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCD 271

Query: 260 ----------DLAALPRLIYLNLSNNLIR-LPTGPPQDSKGIHAPSEGWSALPLSAPSGN 308
                         L +L YLNLS+  +R +     ++   +      ++ L     SG 
Sbjct: 272 GGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASG- 330

Query: 309 ASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLL 368
           A    L +L  LDLS+N I+    S+ +H+      N+SRN  +    R L  L   +  
Sbjct: 331 AFLTMLPRLEILDLSFNYIK---GSYPQHI------NISRNFSKLLSLRAL-HLRGYVFQ 380

Query: 369 DLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGP 428
           +L  +  + L      L +L T+ L  N ++ +    F N ++L+ + L  NR+SP    
Sbjct: 381 ELREDDFQPL----MQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKD 436

Query: 429 DEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTE---------LDLSSNPGL 479
                +   +F     +R     D E +          PL +         LDLS N   
Sbjct: 437 TRQSYANSSSFQ--RHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIF 494

Query: 480 EVATGALGGL-EASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRL--SHLPAWTQAV 536
            +       L + +   L+   N  ++   +      +K L+L  NRL   +  A T+  
Sbjct: 495 FIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELS 554

Query: 537 SLEVLDLRNNS 547
            LEVLDL  NS
Sbjct: 555 DLEVLDLSYNS 565



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 80/268 (29%), Positives = 119/268 (44%), Gaps = 38/268 (14%)

Query: 24  VPCKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTN 83
           + C  +    + QVL   +  ++  P  + LDL+ N+L    AS L   + L  LDLS N
Sbjct: 507 IACLNLSANSNAQVLSGTEFSAI--PHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYN 564

Query: 84  EISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLER 143
              F   G    +TH  HL    N                  +  L+LS N++Y+ L ++
Sbjct: 565 SHYFRIAG----VTH--HLEFIQN---------------FTNLKVLNLSHNNIYT-LTDK 602

Query: 144 LLGEAPSLHTLSLAENSLTRLTR-------HTFRDMPALEQLDLHSNVLMDIEDGAFEGL 196
              E+ SL  L  + N L  L           F+ +  L +LDL  N L  I + AF  L
Sbjct: 603 YNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNL 662

Query: 197 P-RLTHLNLSRNSLTCISDFSLQQ---LRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRE 252
           P  LT L+++ N L   +   LQQ   L +LDL  N +  F T S       L  L L  
Sbjct: 663 PASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKL-LFLTDSLSDFTSSLRTLLLSH 721

Query: 253 NKLLHFPD--LAALPRLIYLNLSNNLIR 278
           N++ H P   L+ +  L +L+LS+NL++
Sbjct: 722 NRISHLPSGFLSEVSSLKHLDLSSNLLK 749



 Score = 29.6 bits (65), Expect = 9.3
 Identities = 31/125 (24%), Positives = 55/125 (44%), Gaps = 13/125 (10%)

Query: 448 LSLVDNEIELLRAGAFLHTP-LTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVL 506
           L L DN I  +   +F     LT+++L+ NP ++   G  G          +Q NGL + 
Sbjct: 68  LDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPG----------IQSNGLNIT 117

Query: 507 QVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRL 566
                    L+ L L +N+L  +P+       E+  ++NN +++        +  +L+ L
Sbjct: 118 DGAFLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLI--NLKNL 175

Query: 567 YLQGN 571
           YL  N
Sbjct: 176 YLAWN 180


>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
           sapiens]
          Length = 592

 Score =  110 bits (275), Expect = 4e-24
 Identities = 116/398 (29%), Positives = 171/398 (42%), Gaps = 55/398 (13%)

Query: 6   LLLLALLTLGLAAQHQDKVP----CKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQL 61
           +L L LL L  A       P    C +  + V+C    L  VP  +P +T  L+LS N++
Sbjct: 7   VLSLPLLLLPAAPPPAGGCPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRI 66

Query: 62  RSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLG 121
           R +    L    AL  LDLS N I+ ++PGAF  L  L  L L  N+L +   +  G   
Sbjct: 67  RCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKL---IPPGVFT 123

Query: 122 PLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLH 181
            L  +T LDLS                         EN L  L  +TF+D+ +L +L++ 
Sbjct: 124 RLDNLTLLDLS-------------------------ENKLVILLDYTFQDLHSLRRLEVG 158

Query: 182 SNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQA 241
            N L+ +   AF GL  L  L L R +LT +S  SL  LR   L    +     AS    
Sbjct: 159 DNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHLR--SLGALRLRHLAIASLEDQ 216

Query: 242 EFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALP 301
            F+                   LP L++L + N  + L        +G++  S   +   
Sbjct: 217 NFR------------------RLPGLLHLEIDNWPL-LEEVAAGSLRGLNLTSLSVTHTN 257

Query: 302 LSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGS 361
           ++A    A+ R  + L  L+LS+N I  +P      L  L  L+L+   L   E +    
Sbjct: 258 ITAVPA-AALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLG 316

Query: 362 LPCLMLLDLSHNALETLELGA-RALGSLRTLLLQGNAL 398
           L  + LL+LS+N L TLE     ++ +L TL + GN L
Sbjct: 317 LRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPL 354



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 61/191 (31%), Positives = 88/191 (46%), Gaps = 29/191 (15%)

Query: 367 LLDLSHNALETLELG-ARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPC 425
           LL+LS N +  L  G   AL +L  L L  NA+  + P  FANL  L+ L L+GN++   
Sbjct: 58  LLELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLI 117

Query: 426 GGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAF--LHTPLTELDLSSNPGLEVAT 483
                PG      F+ + +L  L L +N++ +L    F  LH+ L  L++  N  + V+ 
Sbjct: 118 ----PPG-----VFTRLDNLTLLDLSENKLVILLDYTFQDLHS-LRRLEVGDNDLVFVSR 167

Query: 484 GALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRL-NLAENRLSHLPAWTQAVSLEVLD 542
            A  GL A LE L L+   L  L  +      L  L +L   RL H         L +  
Sbjct: 168 RAFAGLLA-LEELTLERCNLTALSGE-----SLGHLRSLGALRLRH---------LAIAS 212

Query: 543 LRNNSFSLLPG 553
           L + +F  LPG
Sbjct: 213 LEDQNFRRLPG 223


>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
           sapiens]
          Length = 606

 Score =  108 bits (270), Expect = 2e-23
 Identities = 105/378 (27%), Positives = 169/378 (44%), Gaps = 50/378 (13%)

Query: 2   RPQILLLLALLTLGLAAQHQDKVPCKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQL 61
           +P + L + L+ +G       +  C   +K VSC    L+ +P  +P +T+ LDLS N+L
Sbjct: 10  QPFLGLAVVLIFMGSTIGCPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRL 69

Query: 62  RSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLG 121
           +S+       Y  L  +DLS N I+ ++PGAF  L +L  L L  NRL +          
Sbjct: 70  KSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLV--------- 120

Query: 122 PLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLH 181
           PL            +++GL         +L  L ++EN +  L  + F+D+  L+ L++ 
Sbjct: 121 PL-----------GVFTGL--------SNLTKLDISENKIVILLDYMFQDLHNLKSLEVG 161

Query: 182 SNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQA 241
            N L+ I   AF GL  L  L L + +LT +   +L  LR   L    ++     + P  
Sbjct: 162 DNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLR--SLISLHLKHLNINNMPVY 219

Query: 242 EFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALP 301
            F+  +  L+  ++ ++P L  +P       +N+L  L      +   +   +   S +P
Sbjct: 220 AFKRLF-HLKHLEIDYWPLLDMMP-------ANSLYGL------NLTSLSVTNTNLSTVP 265

Query: 302 LSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGS 361
             A       + L  L +L+LSYN I  I       L  L  L++    LRT E      
Sbjct: 266 FLA------FKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQG 319

Query: 362 LPCLMLLDLSHNALETLE 379
           L  L +L++S N LETLE
Sbjct: 320 LRFLRVLNVSQNLLETLE 337



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 65/242 (26%), Positives = 107/242 (44%), Gaps = 28/242 (11%)

Query: 344 LNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGA-RALGSLRTLLLQGNALRDLP 402
           L+LS+N L++       S P L  +DLS N +  +E GA   L +LR+L L+GN L+ +P
Sbjct: 62  LDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVP 121

Query: 403 PYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGA 462
              F  L++L +L++  N++                F  + +L+SL + DN++  +   A
Sbjct: 122 LGVFTGLSNLTKLDISENKIVILLD---------YMFQDLHNLKSLEVGDNDLVYISHRA 172

Query: 463 FLH-TPLTELDLSSNPGLEVATGALGGLEA--SLEVLALQGNGLMVLQVDLPCFICLKRL 519
           F     L +L L       V T AL  L +  SL +  L  N       ++P +   +  
Sbjct: 173 FSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNIN-------NMPVYAFKRLF 225

Query: 520 NLAENRLSHLPAWTQ-------AVSLEVLDLRNNSFSLLPGSAMGGLETSLRRLYLQGNP 572
           +L    + + P            ++L  L + N + S +P  A   L   L  L L  NP
Sbjct: 226 HLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLSTVPFLAFKHL-VYLTHLNLSYNP 284

Query: 573 LS 574
           +S
Sbjct: 285 IS 286



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 52/180 (28%), Positives = 83/180 (46%), Gaps = 7/180 (3%)

Query: 52  ETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAH-NRLA 110
           E L L    L ++    L    +L  L L    I+ +   AF+ L HL+HL + +   L 
Sbjct: 180 EQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLD 239

Query: 111 MATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFR 170
           M  A S  GL     +TSL ++  +L S +          L  L+L+ N ++ +    F 
Sbjct: 240 MMPANSLYGLN----LTSLSVTNTNL-STVPFLAFKHLVYLTHLNLSYNPISTIEAGMFS 294

Query: 171 DMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLD-LSCNS 229
           D+  L++L +    L  IE  +F+GL  L  LN+S+N L  + +      R L+ LS N+
Sbjct: 295 DLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINN 354



 Score = 35.0 bits (79), Expect = 0.22
 Identities = 45/221 (20%), Positives = 80/221 (36%), Gaps = 38/221 (17%)

Query: 37  VLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQAL 96
           +L ++   S+   +  +L ++   L ++          L HL+LS N IS ++ G F  L
Sbjct: 237 LLDMMPANSLYGLNLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDL 296

Query: 97  THLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSL 156
             L+ L +   +L      S  GL                              L  L++
Sbjct: 297 IRLQELHIVGAQLRTIEPHSFQGL----------------------------RFLRVLNV 328

Query: 157 AENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFS 216
           ++N L  L  + F    ALE L +++N L   +      L R   L        C    +
Sbjct: 329 SQNLLETLEENVFSSPRALEVLSINNNPLA-CDCRLLWILQRQPTLQFGGQQPMCAGPDT 387

Query: 217 LQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLH 257
           +++    D    ++  + T  +P+         +RE KL H
Sbjct: 388 IRERSFKDFHSTALSFYFTCKKPK---------IREKKLQH 419


>gi|11321571 slit homolog 3 [Homo sapiens]
          Length = 1523

 Score =  108 bits (270), Expect = 2e-23
 Identities = 126/490 (25%), Positives = 202/490 (41%), Gaps = 76/490 (15%)

Query: 1   MRPQILLLLALLTLGLAAQHQDKVP--CKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSG 58
           +R ++ L LAL ++ L+       P  C      V C  LGL  VP  +P + E LDL  
Sbjct: 12  VRARLALALALASV-LSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDR 70

Query: 59  NQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAG 118
           N +  I          LR L L  N++S ++ GAFQ L  LE L L  N+L +       
Sbjct: 71  NNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQV------- 123

Query: 119 GLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQL 178
                                L E L    P L  L L+EN +  + R  FR +  ++ L
Sbjct: 124 ---------------------LPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNL 162

Query: 179 DLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLT--CISDFS-LQQLRVLDLSCNSIEAFQT 235
            L +N +  IEDGAF  L  L  L L+ N+++   ++ F+ + ++R L L  N +     
Sbjct: 163 QLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHL----- 217

Query: 236 ASQPQAEFQLTWLD--LRENKLLHFPDLAALP-RLIYLNLSNNLIRLPTGPPQDSKGIHA 292
                 +  L WL   LR+ + +    L   P  L   N+++   +    P       H+
Sbjct: 218 ----YCDCHLAWLSDWLRQRRTVGQFTLCMAPVHLRGFNVADVQKKEYVCPAP-----HS 268

Query: 293 PSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLR 352
                +A  +S PS       +     +D     +  IP +  E +     + L +N ++
Sbjct: 269 EPPSCNANSISCPSPCTCSNNI-----VDCRGKGLMEIPANLPEGIVE---IRLEQNSIK 320

Query: 353 TFEARRLGSLPCLMLLDLSHNALETLELGA-RALGSLRTLLLQGNALRDLPPYTFANLAS 411
              A        L  +D+S N +  +   A + L SL +L+L GN + ++    F  L S
Sbjct: 321 AIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVS 380

Query: 412 LQRLNLQGNRVSPCGGPDEPGPSGCV---AFSGITSLRSLSLVDNEIELLRAGAFLH-TP 467
           LQ L L  N+++            C+    F  + +L  LSL DN+++ +  G F     
Sbjct: 381 LQLLLLNANKIN------------CLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQS 428

Query: 468 LTELDLSSNP 477
           +  L L+ NP
Sbjct: 429 IQTLHLAQNP 438



 Score =  104 bits (260), Expect = 2e-22
 Identities = 146/613 (23%), Positives = 231/613 (37%), Gaps = 112/613 (18%)

Query: 25  PCKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNE 84
           PC   +  V C+  GL+++P+ LP     + L  N +++I A     Y  L+ +D+S N+
Sbjct: 283 PCTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQ 342

Query: 85  ISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERL 144
           IS + P AFQ L  L  L L  N++   T ++ G                 L+ GL+   
Sbjct: 343 ISDIAPDAFQGLKSLTSLVLYGNKI---TEIAKG-----------------LFDGLV--- 379

Query: 145 LGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNL 204
                SL  L L  N +  L  +TF+D+  L  L L+ N L  I  G F  L  +  L+L
Sbjct: 380 -----SLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHL 434

Query: 205 SRNSLTC----------------------------ISDFSLQQLRVLDLSCNSIEAFQTA 236
           ++N   C                            +++  + Q++     C+  E +++ 
Sbjct: 435 AQNPFVCDCHLKWLADYLQDNPIETSGARCSSPRRLANKRISQIKSKKFRCSGSEDYRSR 494

Query: 237 SQPQAEFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEG 296
              +    L             P+       I    +  L+R+P+  P+    +      
Sbjct: 495 FSSECFMDLV-----------CPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNE 543

Query: 297 WSALPLSAPSGNASG--RPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTF 354
            S L        A+G  + L  L  ++LS N+I+ + +   +   S+  L L+ N L T 
Sbjct: 544 VSVL-------EATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETV 596

Query: 355 EARRLGSLPCLMLLDLSHNALETLELGARA-LGSLRTLLLQGNALRDLPPYTFANLASLQ 413
             R    L  L  L L  N +  +     A L S+R L L  N +  + P  F  L SL 
Sbjct: 597 HGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLS 656

Query: 414 RLNLQGN-----------------RVSPCGGPDEPGPSGCVAFSGITSLRSLSLVD---- 452
            +NL  N                 R    G P    P     F     ++ +++ D    
Sbjct: 657 TINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPRCQKP----FFLKEIPIQDVAIQDFTCD 712

Query: 453 -NEIELLRAGAFLHTPLTELDL---SSNPGLEVATGALGGLEASLEVLALQGNGLMVLQV 508
            NE    +         T ++     SN GL        G+   +  L L+GN L  +  
Sbjct: 713 GNEESSCQLSPRCPEQCTCMETVVRCSNKGLRALP---RGMPKDVTELYLEGNHLTAVPR 769

Query: 509 DLPCFICLKRLNLAENRLSHLPAWT--QAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRL 566
           +L     L  ++L+ N +S L  +T      L  L L  N    +P  A  GL  SLR L
Sbjct: 770 ELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLR-SLRVL 828

Query: 567 YLQGNPLSCCGNG 579
            L GN +S    G
Sbjct: 829 TLHGNDISSVPEG 841



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 103/463 (22%), Positives = 163/463 (35%), Gaps = 145/463 (31%)

Query: 26  CKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTAL---RHLDLST 82
           C+     V C    L+++PS LP     L L+ N++  + A+  G +  L   R ++LS 
Sbjct: 509 CRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEAT--GIFKKLPNLRKINLSN 566

Query: 83  NEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLE 142
           N+I  ++ GAF     ++ L L  N+L         GL                      
Sbjct: 567 NKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLS--------------------- 605

Query: 143 RLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHL 202
                   L TL L  N +  ++  TF  + ++  L L+ N +  I  GAF  L  L+ +
Sbjct: 606 -------GLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTI 658

Query: 203 NLSRNSLTC----------------------------ISDFSLQQLRVLDLSCNSIEAFQ 234
           NL  N   C                            + +  +Q + + D +C+  E   
Sbjct: 659 NLLSNPFNCNCHLAWLGKWLRKRRIVSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNEESS 718

Query: 235 TASQPQAEFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIR-LPTGPPQDSKGIHAP 293
               P+   Q T ++                    +  SN  +R LP G P+D       
Sbjct: 719 CQLSPRCPEQCTCMET------------------VVRCSNKGLRALPRGMPKD------- 753

Query: 294 SEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRT 353
                                  +  L L  N +  +P                      
Sbjct: 754 -----------------------VTELYLEGNHLTAVP---------------------- 768

Query: 354 FEARRLGSLPCLMLLDLSHNALETL-ELGARALGSLRTLLLQGNALRDLPPYTFANLASL 412
              R L +L  L L+DLS+N++  L       +  L TL+L  N LR +P + F  L SL
Sbjct: 769 ---RELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSL 825

Query: 413 QRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEI 455
           + L L GN +S         P G  +F+ +TSL  L+L  N +
Sbjct: 826 RVLTLHGNDISSV-------PEG--SFNDLTSLSHLALGTNPL 859



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 91/367 (24%), Positives = 145/367 (39%), Gaps = 57/367 (15%)

Query: 126 VTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVL 185
           VT L L+ N +       +  + P+L  ++L+ N +  +    F    ++++L L  N L
Sbjct: 534 VTDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQL 593

Query: 186 MDIEDGAFEGLPRLTHLNLSRNSLTCISDFS---LQQLRVLDLSCNSIEAFQTASQPQAE 242
             +    F GL  L  L L  N + C+S+ +   L  +R+L L  N I    T       
Sbjct: 594 ETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTI-TPGAFTTL 652

Query: 243 FQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPL 302
             L+ ++L  N       LA L + +         R+ +G P+  K              
Sbjct: 653 VSLSTINLLSNPFNCNCHLAWLGKWLRKR------RIVSGNPRCQKPFFLKEI------- 699

Query: 303 SAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTF---EARRL 359
                     P+  +   D + +  E             C       C+ T      + L
Sbjct: 700 ----------PIQDVAIQDFTCDGNEESSCQLSPRCPEQC------TCMETVVRCSNKGL 743

Query: 360 GSLPCLMLLDLSHNALETLELGA--RALGSLRTLLL---QGNALRDLPPYTFANLASLQR 414
            +LP  M  D++   LE   L A  R L +LR L L     N++  L  YTF+N++ L  
Sbjct: 744 RALPRGMPKDVTELYLEGNHLTAVPRELSALRHLTLIDLSNNSISMLTNYTFSNMSHLST 803

Query: 415 LNLQGNRVSPCGGPDEPGPSGCV---AFSGITSLRSLSLVDNEIELLRAGAFLH-TPLTE 470
           L L  NR+             C+   AF+G+ SLR L+L  N+I  +  G+F   T L+ 
Sbjct: 804 LILSYNRLR------------CIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSH 851

Query: 471 LDLSSNP 477
           L L +NP
Sbjct: 852 LALGTNP 858



 Score = 56.2 bits (134), Expect = 9e-08
 Identities = 51/195 (26%), Positives = 74/195 (37%), Gaps = 55/195 (28%)

Query: 26  CKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEI 85
           C  ++  V C   GL  +P  +P D   L L GN L ++                     
Sbjct: 729 CTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAV--------------------- 767

Query: 86  SFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLL 145
               P    AL HL  + L++N ++M T                    N  +S +     
Sbjct: 768 ----PRELSALRHLTLIDLSNNSISMLT--------------------NYTFSNMSH--- 800

Query: 146 GEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLS 205
                L TL L+ N L  +  H F  + +L  L LH N +  + +G+F  L  L+HL L 
Sbjct: 801 -----LSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALG 855

Query: 206 RNSLTCISDFSLQQL 220
            N L C  D SL+ L
Sbjct: 856 TNPLHC--DCSLRWL 868


>gi|4507531 toll-like receptor 3 [Homo sapiens]
          Length = 904

 Score =  105 bits (263), Expect = 1e-22
 Identities = 167/638 (26%), Positives = 256/638 (40%), Gaps = 104/638 (16%)

Query: 26  CKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEI 85
           C +  +   C  L L QVP  LP +   L+L+ NQLR + A+    Y+ L  LD+  N I
Sbjct: 28  CTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTI 87

Query: 86  SFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSL--------- 136
           S L+P   Q L  L+ L+L HN L+    LS         +T L L  NS+         
Sbjct: 88  SKLEPELCQKLPMLKVLNLQHNELSQ---LSDKTFAFCTNLTELHLMSNSIQKIKNNPFV 144

Query: 137 -----------YSGLLERLLG---EAPSLHTLSLAENSLTRLTRHTFRDMP--ALEQLDL 180
                      ++GL    LG   +  +L  L L+ N +  L           +L++L+L
Sbjct: 145 KQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSSLKKLEL 204

Query: 181 HSNVLMDIEDGAFEGLPRL---------------------------THLNLSRNSLTCIS 213
            SN + +   G F  + RL                            +L+LS + L+  S
Sbjct: 205 SSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTS 264

Query: 214 DFSLQQLR-----VLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHF--PDLAALPR 266
           + +   L+     +LDLS N++      S      QL +  L  N + H     L  L  
Sbjct: 265 NTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLP-QLEYFFLEYNNIQHLFSHSLHGLFN 323

Query: 267 LIYLNLSNNL----IRLPTGPPQDSKGI-------HAPSEGWSALPLSAPSGNASGRPLS 315
           + YLNL  +     I L + P  D           H   E  + +P    S   +G    
Sbjct: 324 VRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMED-NDIP-GIKSNMFTGLINL 381

Query: 316 QLLNLDLSYNEIELIPDSFLEHL--TSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHN 373
           + L+L  S+  +  + +     L  + L  LNL++N +   E+     L  L +LDL  N
Sbjct: 382 KYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLN 441

Query: 374 ALETLELGA--RALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEP 431
            +     G   R L ++  + L  N    L   +FA + SLQRL L+  RV+       P
Sbjct: 442 EIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLR--RVALKNVDSSP 499

Query: 432 GPSGCVAFSGITSLRSLSLVDNEI-----------ELLRAGAFLHTPLTELDLSSNPGLE 480
            P     F  + +L  L L +N I           E L      H  L  L   +NPG  
Sbjct: 500 SP-----FQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGP 554

Query: 481 VATGALGGLEASLEVLALQGNGLMVLQVDL-PCFICLKRLNLAENRLSHLPA--WTQAVS 537
           +    L GL + L +L L+ NG   + V++      LK ++L  N L+ LPA  +   VS
Sbjct: 555 IYF--LKGL-SHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVS 611

Query: 538 LEVLDLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLSC 575
           L+ L+L+ N  + +     G    +L  L ++ NP  C
Sbjct: 612 LKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDC 649


>gi|62912470 leucine-rich repeat-containing G protein-coupled
           receptor 6 isoform 1 [Homo sapiens]
          Length = 967

 Score =  105 bits (261), Expect = 2e-22
 Identities = 125/463 (26%), Positives = 188/463 (40%), Gaps = 93/463 (20%)

Query: 35  CQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQ 94
           C  LGL  VP  L P T  LDLS N L  +          L  L LS N +S +   AF 
Sbjct: 52  CSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFS 111

Query: 95  ALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSL-------YSGLLE----- 142
            L  L+ L L +N+L     + A  L  LP + SL L  N +       + GL       
Sbjct: 112 GLYSLKILMLQNNQLG---GIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLW 168

Query: 143 -----------RLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDG 191
                      R L   P+L  ++LA N ++ +  + F+++ +L  L LH+N +  +   
Sbjct: 169 LDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTH 228

Query: 192 AFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLR 251
           +FEG                     L  L  LDL+ N ++ F  A +     Q   L   
Sbjct: 229 SFEG---------------------LHNLETLDLNYNKLQEFPVAIRTLGRLQ--ELGFH 265

Query: 252 ENKLLHFPDLAAL--PRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNA 309
            N +   P+ A +  P L  ++  +N I+                            G +
Sbjct: 266 NNNIKAIPEKAFMGNPLLQTIHFYDNPIQF--------------------------VGRS 299

Query: 310 SGRPLSQLLNLDLS-YNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLL 368
           + + L +L  L L+   +I+  PD  L+  TSL  L L+R  +R   +     LP L +L
Sbjct: 300 AFQYLPKLHTLSLNGAMDIQEFPD--LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVL 357

Query: 369 DLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGP 428
           +LSHN +E L         L  + LQ N + ++   TF+ L+SLQ L+L  N +     P
Sbjct: 358 ELSHNQIEELP-SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSI-HP 415

Query: 429 DEPGPSGCVAFSGITSLRSLSLVDNE---IELLRAGAFLHTPL 468
           +        AFS + SL  L L DN+   + L   G  +H  L
Sbjct: 416 E--------AFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKL 450



 Score = 86.7 bits (213), Expect = 6e-17
 Identities = 120/425 (28%), Positives = 173/425 (40%), Gaps = 63/425 (14%)

Query: 173 PALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEA 232
           P    LDL  N L +++ G F  L  L  L LS N L+ I   +   L            
Sbjct: 66  PLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGL------------ 113

Query: 233 FQTASQPQAEFQLTWLDLRENKLLHFPDLAA--LPRLIYLNLSNNLIRLPTGPPQDSKGI 290
                     + L  L L+ N+L   P  A   LP L  L L  NLI L   P +  +G+
Sbjct: 114 ----------YSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLV--PERSFEGL 161

Query: 291 HAPSEGW------SALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFL 344
            +    W      + +P+ A +       L  L  + L+ N I  IPD   ++LTSL  L
Sbjct: 162 SSLRHLWLDDNALTEIPVRALNN------LPALQAMTLALNRISHIPDYAFQNLTSLVVL 215

Query: 345 NLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPY 404
           +L  N ++         L  L  LDL++N L+   +  R LG L+ L    N ++ +P  
Sbjct: 216 HLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEK 275

Query: 405 TFANLASLQRLNLQGNRVSPCGGP-----------DEPGPSGCVAF---SGITSLRSLSL 450
            F     LQ ++   N +   G                G      F    G TSL  L+L
Sbjct: 276 AFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTL 335

Query: 451 VDNEIELLRAGAFLHTP-LTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVD 509
               I LL +G     P L  L+LS N   E+   +L   +  LE + LQ N +  +  D
Sbjct: 336 TRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP--SLHRCQ-KLEEIGLQHNRIWEIGAD 392

Query: 510 -LPCFICLKRLNLAEN--RLSHLPAWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRL 566
                  L+ L+L+ N  R  H  A++   SL  LDL +N  + LP + +GG    L  L
Sbjct: 393 TFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGG----LMHL 448

Query: 567 YLQGN 571
            L+GN
Sbjct: 449 KLKGN 453



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 31/83 (37%), Positives = 39/83 (46%), Gaps = 6/83 (7%)

Query: 52  ETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAM 111
           E + L  N++  I A      ++L+ LDLS N I  + P AF  L  L  L L  N+L  
Sbjct: 377 EEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQL-- 434

Query: 112 ATALSAGGLGPLPRVTSLDLSGN 134
            T L   GLG L     L L GN
Sbjct: 435 -TTLPLAGLGGL---MHLKLKGN 453


>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
          Length = 582

 Score =  104 bits (260), Expect = 2e-22
 Identities = 128/432 (29%), Positives = 192/432 (44%), Gaps = 34/432 (7%)

Query: 123 LPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHS 182
           L ++T L L  N L S  L   +G   +L TL+L+ENSLT L   +  ++  L  LDL  
Sbjct: 122 LTQLTELYLYSNKLQS--LPAEVGCLVNLMTLALSENSLTSLP-DSLDNLKKLRMLDLRH 178

Query: 183 NVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDF--SLQQLRVLDLSCNSIEAFQTASQPQ 240
           N L +I    +  L  LT L L  N +T +     +L +L +L +  N I+  Q  ++  
Sbjct: 179 NKLREIPSVVYR-LDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIK--QLPAEIG 235

Query: 241 AEFQLTWLDLRENKLLHFP-DLAALPRLIYLNLSNN-LIRLPT--GPPQDSKGIHAPSEG 296
               L  LD+  N+L H P ++    ++  L+L +N L+ LP   G       +      
Sbjct: 236 ELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNR 295

Query: 297 WSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEA 356
            SA+P S    +A       L  L+L  N I  +P+S L  L  L  L L+RNC + +  
Sbjct: 296 LSAIPRSLAKCSA-------LEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPV 348

Query: 357 RRLGSLPCLMLLDLSHNALETLELGARALGS-LRTLLLQGNALRDLPPYTFANLASLQRL 415
                   +  L++ HN +  +  G  +    L  L ++ N L  L P  F    S+  L
Sbjct: 349 GGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSL-PLDFGTWTSMVEL 407

Query: 416 NLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSS 475
           NL  N+++    P++         SG+ SL  L L +N ++ L  G      L ELDL  
Sbjct: 408 NLATNQLTKI--PED--------VSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEE 457

Query: 476 NPGLEVATGALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQA 535
           N  LE     +  L+  L+ L L  N L  L   +     L  L L EN L+HLP     
Sbjct: 458 NK-LESLPNEIAYLK-DLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGT 515

Query: 536 V-SLEVLDLRNN 546
           + +LE L L +N
Sbjct: 516 LENLEELYLNDN 527



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 115/398 (28%), Positives = 170/398 (42%), Gaps = 58/398 (14%)

Query: 202 LNLSRNSLTCI--SDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFP 259
           L+LS+ S+  +  S   L QL  L L  N +++    ++      L  L L EN L   P
Sbjct: 105 LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLP--AEVGCLVNLMTLALSENSLTSLP 162

Query: 260 D-LAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLL 318
           D L  L +L  L+L +N +R              PS  +                L  L 
Sbjct: 163 DSLDNLKKLRMLDLRHNKLR------------EIPSVVYR---------------LDSLT 195

Query: 319 NLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETL 378
            L L +N I  + +  +++L+ L  L++  N ++   A  +G L  L+ LD++HN LE L
Sbjct: 196 TLYLRFNRITTV-EKDIKNLSKLSMLSIRENKIKQLPAE-IGELCNLITLDVAHNQLEHL 253

Query: 379 ELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSP-------CGGPDEP 431
                    +  L LQ N L DLP  T  NL+SL RL L+ NR+S        C   +E 
Sbjct: 254 PKEIGNCTQITNLDLQHNELLDLPD-TIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEEL 312

Query: 432 G---------PSGCVAFSGITSLRSLSLVDNEIELLRAGA-FLHTPLTELDLSSNPGLEV 481
                     P   +  S +  L SL+L  N  +L   G     + +  L++  N   ++
Sbjct: 313 NLENNNISTLPESLL--SSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKI 370

Query: 482 ATGALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQA-VSLEV 540
             G     +  L  L ++ N L  L +D   +  +  LNLA N+L+ +P      VSLEV
Sbjct: 371 PFGIFSRAKV-LSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEV 429

Query: 541 LDLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLSCCGN 578
           L L NN    LP   +G L   LR L L+ N L    N
Sbjct: 430 LILSNNLLKKLP-HGLGNLR-KLRELDLEENKLESLPN 465



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 62/230 (26%), Positives = 92/230 (40%), Gaps = 38/230 (16%)

Query: 366 MLLDLSHNALETLELGARALGSLRTLLLQGNALRDLP----------------------P 403
           M LDLS  ++  L    + L  L  L L  N L+ LP                      P
Sbjct: 103 MRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLP 162

Query: 404 YTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAF-------------SGITSLRSLSL 450
            +  NL  L+ L+L+ N++           S    +               ++ L  LS+
Sbjct: 163 DSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSI 222

Query: 451 VDNEIELLRAGAFLHTPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVDL 510
            +N+I+ L A       L  LD++ N  LE     +G     +  L LQ N L+ L   +
Sbjct: 223 RENKIKQLPAEIGELCNLITLDVAHNQ-LEHLPKEIGNC-TQITNLDLQHNELLDLPDTI 280

Query: 511 PCFICLKRLNLAENRLSHLP-AWTQAVSLEVLDLRNNSFSLLPGSAMGGL 559
                L RL L  NRLS +P +  +  +LE L+L NN+ S LP S +  L
Sbjct: 281 GNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSL 330



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 52/156 (33%), Positives = 73/156 (46%), Gaps = 12/156 (7%)

Query: 54  LDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMAT 113
           L++  NQL S L    G +T++  L+L+TN+++ + P     L  LE L L++N L    
Sbjct: 384 LNMKDNQLTS-LPLDFGTWTSMVELNLATNQLTKI-PEDVSGLVSLEVLILSNNLLKKLP 441

Query: 114 ALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMP 173
                GLG L ++  LDL  N L S  L   +     L  L L  N LT L R     + 
Sbjct: 442 H----GLGNLRKLRELDLEENKLES--LPNEIAYLKDLQKLVLTNNQLTTLPR-GIGHLT 494

Query: 174 ALEQLDLHSNVLMDI--EDGAFEGLPRLTHLNLSRN 207
            L  L L  N+L  +  E G  E L  L +LN + N
Sbjct: 495 NLTHLGLGENLLTHLPEEIGTLENLEEL-YLNDNPN 529


>gi|12007646 nyctalopin precursor [Homo sapiens]
          Length = 481

 Score =  103 bits (256), Expect = 7e-22
 Identities = 110/366 (30%), Positives = 152/366 (41%), Gaps = 71/366 (19%)

Query: 2   RPQILLLLALLTLGL---------AAQHQDKVPCKMVDK--KVSCQVLGLLQVPSVLPPD 50
           R  ++LLL  + LGL         A        C  V++   V C   GLL+VP+ LP +
Sbjct: 4   RGMLVLLLHAVVLGLPSAWAVGACARACPAACACSTVERGCSVRCDRAGLLRVPAELPCE 63

Query: 51  TETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLA 110
             ++DL  N LR +     G   +LR L L  N +SF+ PGAF+ L  L  L LAHN   
Sbjct: 64  AVSIDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHN--G 121

Query: 111 MATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFR 170
               L A     L R+  LDL+   L+S + ERLL E P+L  L+  +N         FR
Sbjct: 122 DLRYLHARTFAALSRLRRLDLAACRLFS-VPERLLAELPALRELAAFDN--------LFR 172

Query: 171 DMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQ---QLRVLDLSC 227
            +P                 GA  GL  LTH +L R  +  ++  SLQ   +LR L L  
Sbjct: 173 RVP-----------------GALRGLANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQA 215

Query: 228 NSIEAFQTASQPQAEFQLTWLDLRENKLLHFPDLA--ALPRLIYLNLSNNLIRLPTGPPQ 285
           N + A    +       L  L L +N L   P  A   L RL  LNL  N          
Sbjct: 216 NRVRAVHAGAFGDCGV-LEHLLLNDNLLAELPADAFRGLRRLRTLNLGGN---------- 264

Query: 286 DSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLN 345
               +   +  W A              L++L  L L  N I  + +   ++L+ L  L+
Sbjct: 265 ---ALDRVARAWFA-------------DLAELELLYLDRNSIAFVEEGAFQNLSGLLALH 308

Query: 346 LSRNCL 351
           L+ N L
Sbjct: 309 LNGNRL 314



 Score = 66.2 bits (160), Expect = 9e-11
 Identities = 61/188 (32%), Positives = 89/188 (47%), Gaps = 27/188 (14%)

Query: 54  LDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMAT 113
           LDL+  +L S+    L    ALR L    N    + PGA + L +L H  L   R+    
Sbjct: 140 LDLAACRLFSVPERLLAELPALRELAAFDNLFRRV-PGALRGLANLTHAHLERGRIE--- 195

Query: 114 ALSAGGLGPLPRVTSLDLSGNSLYS---------GLLERLL------GEAPS-------- 150
           A+++  L  L R+ SL L  N + +         G+LE LL       E P+        
Sbjct: 196 AVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRR 255

Query: 151 LHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLT 210
           L TL+L  N+L R+ R  F D+  LE L L  N +  +E+GAF+ L  L  L+L+ N LT
Sbjct: 256 LRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRLT 315

Query: 211 CISDFSLQ 218
            ++  + Q
Sbjct: 316 VLAWVAFQ 323



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 75/241 (31%), Positives = 97/241 (40%), Gaps = 34/241 (14%)

Query: 344 LNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGA-RALGSLRTLLLQGNA-LRDL 401
           ++L RN LR    R  G+LP L  L L HN L  +  GA + L  L  L L  N  LR L
Sbjct: 67  IDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYL 126

Query: 402 PPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAG 461
              TFA L+ L+RL+L   R+     P+          + + +LR L+  DN    +   
Sbjct: 127 HARTFAALSRLRRLDLAACRLFSV--PER-------LLAELPALRELAAFDNLFRRVPGA 177

Query: 462 AFLHTPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNL 521
                 LT   L       VA+ +L GL   L  L+LQ N +                  
Sbjct: 178 LRGLANLTHAHLERGRIEAVASSSLQGLR-RLRSLSLQANRV------------------ 218

Query: 522 AENRLSHLPAWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLSCCGNGWL 581
              R  H  A+     LE L L +N  + LP  A  GL   LR L L GN L      W 
Sbjct: 219 ---RAVHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLR-RLRTLNLGGNALDRVARAWF 274

Query: 582 A 582
           A
Sbjct: 275 A 275



 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 83/278 (29%), Positives = 111/278 (39%), Gaps = 26/278 (9%)

Query: 316 QLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNAL 375
           + +++DL  N +  + +     L SL  L+L  N L          LP L  L L+HN  
Sbjct: 63  EAVSIDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNG- 121

Query: 376 ETLELGAR---ALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPG 432
           +   L AR   AL  LR L L    L  +P    A L +L+ L    N      G     
Sbjct: 122 DLRYLHARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPG----- 176

Query: 433 PSGCVAFSGITSLRSLSLVDNEIELLRAGAFLH-TPLTELDLSSNPGLEVATGALGGLEA 491
                A  G+ +L    L    IE + + +      L  L L +N    V  GA G    
Sbjct: 177 -----ALRGLANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDC-G 230

Query: 492 SLEVLALQGNGLMVLQVDLPCFICLKR---LNLAENRLSHLP-AW-TQAVSLEVLDLRNN 546
            LE L L  N L  L  D   F  L+R   LNL  N L  +  AW      LE+L L  N
Sbjct: 231 VLEHLLLNDNLLAELPAD--AFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRN 288

Query: 547 SFSLLPGSAMGGLETSLRRLYLQGNPLSCCGNGWLAAQ 584
           S + +   A   L + L  L+L GN L+     W+A Q
Sbjct: 289 SIAFVEEGAFQNL-SGLLALHLNGNRLTVL--AWVAFQ 323



 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 53/180 (29%), Positives = 77/180 (42%), Gaps = 10/180 (5%)

Query: 56  LSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATAL 115
           L   ++ ++ +S L     LR L L  N +  +  GAF     LEHL L  N LA    L
Sbjct: 189 LERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLA---EL 245

Query: 116 SAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPAL 175
            A     L R+ +L+L GN+L   +      +   L  L L  NS+  +    F+++  L
Sbjct: 246 PADAFRGLRRLRTLNLGGNAL-DRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGL 304

Query: 176 EQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTC------ISDFSLQQLRVLDLSCNS 229
             L L+ N L  +   AF+    L  L L RN   C      + D+     RV D+ C S
Sbjct: 305 LALHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCCDCRLEWLRDWMEGSGRVTDVPCAS 364



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 76/270 (28%), Positives = 105/270 (38%), Gaps = 54/270 (20%)

Query: 248 LDLRENKLLHFPDLA--ALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAP 305
           L LR N L      A   LPRL  L L++N          D + +HA +           
Sbjct: 91  LSLRHNNLSFITPGAFKGLPRLAELRLAHN---------GDLRYLHARTFA--------- 132

Query: 306 SGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCL 365
                   LS+L  LDL+   +  +P+  L  L +L  L    N  R       G     
Sbjct: 133 -------ALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPGALRG----- 180

Query: 366 MLLDLSHNALETLELGARALGS------LRTLLLQGNALRDLPPYTFANLASLQRLNLQG 419
            L +L+H  LE   + A A  S      LR+L LQ N +R +    F +   L+ L L  
Sbjct: 181 -LANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLND 239

Query: 420 NRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELD---LSSN 476
           N ++              AF G+  LR+L+L  N ++ +    F    L EL+   L  N
Sbjct: 240 NLLAELPAD---------AFRGLRRLRTLNLGGNALDRVARAWF--ADLAELELLYLDRN 288

Query: 477 PGLEVATGALGGLEASLEVLALQGNGLMVL 506
               V  GA   L + L  L L GN L VL
Sbjct: 289 SIAFVEEGAFQNL-SGLLALHLNGNRLTVL 317



 Score = 36.6 bits (83), Expect = 0.076
 Identities = 23/59 (38%), Positives = 31/59 (52%)

Query: 53  TLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAM 111
           TL+L GN L  +  +       L  L L  N I+F++ GAFQ L+ L  L L  NRL +
Sbjct: 258 TLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRLTV 316


>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
          Length = 545

 Score =  102 bits (255), Expect = 9e-22
 Identities = 109/369 (29%), Positives = 158/369 (42%), Gaps = 33/369 (8%)

Query: 123 LPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHS 182
           +P  T   +   + ++ L  R  G  P+L  +      L +     F  +P LE L++  
Sbjct: 47  IPPYTKNIIFVETSFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTG 106

Query: 183 NVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAE 242
           +  +++    F  L  L  L L+ N L  + +   Q L  L+     ++  Q  + P+  
Sbjct: 107 SSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESL--HLQGNQLQALPRRL 164

Query: 243 FQ----LTWLDLRENKLLHFPD--LAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEG 296
           FQ    L  L+L +N L   P+     L  L  L LSNN +   +G PQ   G     + 
Sbjct: 165 FQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNAL---SGLPQGVFG-----KL 216

Query: 297 WSALPLSAPSGNASGRP---LSQLLNLD---LSYNEIELIPDSFLEHLTSLCFLNLSRNC 350
            S   L   S N S  P    SQL  L+   L  N I  +P S    L +L FL+L  N 
Sbjct: 217 GSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNM 276

Query: 351 LRTFEARRLGSLPCLMLLDLSHNALETLELGARA-LGSLRTLLLQGNALRDLPPYTFANL 409
           LR   A      PCL+ L L+HN LET+  G  A L +LR+L+L  NA+  LP   F +L
Sbjct: 277 LRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDL 336

Query: 410 ASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAF-LHTPL 468
             L +L L  N ++               F  ++ L  LSL  N++  L  G F  +  L
Sbjct: 337 EELVKLYLGSNNLTALHP---------ALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNL 387

Query: 469 TELDLSSNP 477
             L L  NP
Sbjct: 388 FNLALHGNP 396



 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 117/428 (27%), Positives = 171/428 (39%), Gaps = 52/428 (12%)

Query: 6   LLLLALLTLGLAAQHQDKVPCKM----VDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQL 61
           LL  +LL L   AQ     PC M      ++V C    L  VP  +PP T+ +       
Sbjct: 7   LLWTSLLLLARPAQ-----PCPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSF 61

Query: 62  RSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLG 121
            ++     G    L  +     ++   +P AF  L  LE L +  +       LS     
Sbjct: 62  TTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSF---LNLSTNIFS 118

Query: 122 PLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLH 181
            L  +  L L+ N L   L E L     +L +L L  N L  L R  F+ +  L+ L+L 
Sbjct: 119 NLTSLGKLTLNFNML-EALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLA 177

Query: 182 SNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISD---FSLQQLRVLDLSCNSIEAFQTASQ 238
            N+L  + +  F  L  L  L LS N+L+ +       L  L+ L L  N+I        
Sbjct: 178 QNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISEL----P 233

Query: 239 PQAEFQLTWLD---LRENKLLHFP--DLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAP 293
           PQ   QL  L+   L+ N + H P    A+L  L +L+L  N++R+              
Sbjct: 234 PQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRV-------------- 279

Query: 294 SEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRT 353
                      P+G  +  P   L+ L L++N++E + +    HL++L  L LS N +  
Sbjct: 280 ----------LPAGLFAHTPC--LVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITH 327

Query: 354 FEARRLGSLPCLMLLDLSHNALETLELGA-RALGSLRTLLLQGNALRDLPPYTFANLASL 412
             A     L  L+ L L  N L  L     + L  L  L L  N L  LP   F    +L
Sbjct: 328 LPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNL 387

Query: 413 QRLNLQGN 420
             L L GN
Sbjct: 388 FNLALHGN 395



 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 123/468 (26%), Positives = 167/468 (35%), Gaps = 133/468 (28%)

Query: 149 PSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNS 208
           P    +   E S T L    F   P L ++   +  L      AF GLPRL  L ++ +S
Sbjct: 49  PYTKNIIFVETSFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSS 108

Query: 209 LTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPDLAALPRLI 268
                         L+LS N                             F +L +L +L 
Sbjct: 109 F-------------LNLSTNI----------------------------FSNLTSLGKLT 127

Query: 269 YLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIE 328
            LN  N L  LP G  Q                            L+ L +L L  N+++
Sbjct: 128 -LNF-NMLEALPEGLFQH---------------------------LAALESLHLQGNQLQ 158

Query: 329 LIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGARA-LGS 387
            +P    + LT L  LNL++N L          L  L  L LS+NAL  L  G    LGS
Sbjct: 159 ALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGS 218

Query: 388 LRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRS 447
           L+ L L  N + +LPP  F+ L  L+RL LQ N ++               F+ + +L  
Sbjct: 219 LQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLP---------LSIFASLGNLTF 269

Query: 448 LSLVDNEIELLRAGAFLHTP-LTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVL 506
           LSL  N + +L AG F HTP L  L L+ N    VA G    L                 
Sbjct: 270 LSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSN--------------- 314

Query: 507 QVDLPCFICLKRLNLAENRLSHLPA--------------------------WTQAVSLEV 540
                    L+ L L+ N ++HLPA                          +     LE+
Sbjct: 315 ---------LRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLEL 365

Query: 541 LDLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLSC-CGNGWLAAQLHQ 587
           L L  N  + LP   +     +L  L L GNP  C C   +L   L Q
Sbjct: 366 LSLSKNQLTTLP-EGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQ 412



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 63/212 (29%), Positives = 91/212 (42%), Gaps = 12/212 (5%)

Query: 8   LLALLTLGLAAQHQDKVPCKMVDKKVSCQVLGL-LQVPSVLPPDTET----LDLSGNQLR 62
           L +L TL L+      +P  +  K  S Q L L     S LPP   +    L+    Q  
Sbjct: 192 LTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRN 251

Query: 63  SILASPLGFYTALRHL---DLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGG 119
           +I   PL  + +L +L    L  N +  L  G F     L  LSL HN+L     ++ G 
Sbjct: 252 AITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLE---TVAEGT 308

Query: 120 LGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLD 179
              L  + SL LS N++ + L   +  +   L  L L  N+LT L    F+++  LE L 
Sbjct: 309 FAHLSNLRSLMLSYNAI-THLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLS 367

Query: 180 LHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTC 211
           L  N L  + +G F+    L +L L  N   C
Sbjct: 368 LSKNQLTTLPEGIFDTNYNLFNLALHGNPWQC 399


>gi|194440719 chondroadherin-like [Homo sapiens]
          Length = 762

 Score =  102 bits (254), Expect = 1e-21
 Identities = 174/595 (29%), Positives = 231/595 (38%), Gaps = 100/595 (16%)

Query: 3   PQILLLLALLTLGLAAQHQ-DKVP----CKMVDKKVSCQVLGLLQVPSVLPPDTETLDLS 57
           P +L LL LL L  A Q    + P    C    + V+C+   L +VP  +P  T+ LDL 
Sbjct: 11  PLVLPLLVLLLLAPARQAAAQRCPQACICDNSRRHVACRYQNLTEVPDAIPELTQRLDLQ 70

Query: 58  GNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSA 117
           GN L+ I A+       L HLDL   E+  +  GAF+ L  L  L+LA N L      + 
Sbjct: 71  GNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEAL 130

Query: 118 GGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQ 177
            GLG L R   L+L GN+L   L     G   +L TL+LA N+L  L    F+ +  +  
Sbjct: 131 DGLGSLRR---LELEGNAL-EELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRW 186

Query: 178 LDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTAS 237
           L L  N L  +   A  GLP L  L+L  N L  +    L Q R                
Sbjct: 187 LRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQAR---------------- 230

Query: 238 QPQAEFQLTWLDLRENKLLHF--PDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSE 295
                  L  L+L  N L +    D  ALP L  L L    ++   GP   +   H P  
Sbjct: 231 ------GLARLELGHNPLTYAGEEDGLALPGLRELLLDGGALQ-ALGPRAFA---HCP-- 278

Query: 296 GWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRT-F 354
                               +L  LDL  N+++ +P   L+    L  L L  N L    
Sbjct: 279 --------------------RLHTLDLRGNQLDTLPP--LQGPGQLRRLRLQGNPLWCGC 316

Query: 355 EARRLGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTF-------A 407
           +AR L          L   A   +       G  R   L+G AL  L P+          
Sbjct: 317 QARPL----------LEWLARARVRSDGACQGPRR---LRGEALDALRPWDLRCPGDAAQ 363

Query: 408 NLASLQRLNLQGNRVSPCGGPDEPG--------PSGCVAFSGITSLRSLSLVDNEIELLR 459
               L+   + G R  P G P  PG        P  CV    +   R  S     ++ + 
Sbjct: 364 EEEELEERAVAGPRAPPRGPPRGPGEERAVAPCPRACVC---VPESRHSSCEGCGLQAVP 420

Query: 460 AGAFLHTPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVD-LPCFICLKR 518
            G    T L  LDL  N    V   A  GL   L  L LQ  G+  L+   L     L  
Sbjct: 421 RGFPSDTQL--LDLRRNHFPSVPRAAFPGL-GHLVSLHLQHCGIAELEAGALAGLGRLIY 477

Query: 519 LNLAENRLSHL--PAWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRLYLQGN 571
           L L++N+L+ L   A   A  L  L L  N F  +PG+A+  L  SL  L+LQ N
Sbjct: 478 LYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQVPGAALRAL-PSLFSLHLQDN 531



 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 104/322 (32%), Positives = 132/322 (40%), Gaps = 43/322 (13%)

Query: 275 NLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSF 334
           NL  +P   P+ ++ +         +P +A  G      +  L +LDL + E+EL+ +  
Sbjct: 52  NLTEVPDAIPELTQRLDLQGNLLKVIPAAAFQG------VPHLTHLDLRHCEVELVAEGA 105

Query: 335 LEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGA-RALGSLRTLLL 393
              L  L  LNL+ N LR      L  L  L  L+L  NALE L  G   ALG+L TL L
Sbjct: 106 FRGLGRLLLLNLASNHLRELPQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNL 165

Query: 394 QGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDN 453
             NAL  LP   F  L  ++ L L  N +S    P+        A +G+ +LR LSL  N
Sbjct: 166 AHNALVYLPAMAFQGLLRVRWLRLSHNALSVL-APE--------ALAGLPALRRLSLHHN 216

Query: 454 EIELLRAGAFLHT-PLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVDLPC 512
           E++ L          L  L+L  NP L  A    G     L  L L G  L         
Sbjct: 217 ELQALPGPVLSQARGLARLELGHNP-LTYAGEEDGLALPGLRELLLDGGALQA------- 268

Query: 513 FICLKRLNLAENRLSHLPAWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRLYLQGNP 572
                   L     +H P       L  LDLR N    LP     G    LRRL LQGNP
Sbjct: 269 --------LGPRAFAHCP------RLHTLDLRGNQLDTLPPLQGPG---QLRRLRLQGNP 311

Query: 573 LSC-CGNGWLAAQLHQGRVDVD 593
           L C C    L   L + RV  D
Sbjct: 312 LWCGCQARPLLEWLARARVRSD 333



 Score = 92.8 bits (229), Expect = 9e-19
 Identities = 164/590 (27%), Positives = 229/590 (38%), Gaps = 76/590 (12%)

Query: 11  LLTLGLAAQHQDKVPCKMVDKKVSCQVLGLL-QVPSVLPPDT-------ETLDLSGNQLR 62
           LL L LA+ H  ++P + +D   S + L L       L P T        TL+L+ N L 
Sbjct: 112 LLLLNLASNHLRELPQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALV 171

Query: 63  SILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRL--------AMATA 114
            + A        +R L LS N +S L P A   L  L  LSL HN L        + A  
Sbjct: 172 YLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARG 231

Query: 115 LSAGGLG-------------PLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSL 161
           L+   LG              LP +  L L G +L + L  R     P LHTL L  N L
Sbjct: 232 LARLELGHNPLTYAGEEDGLALPGLRELLLDGGALQA-LGPRAFAHCPRLHTLDLRGNQL 290

Query: 162 TRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSR--NSLTC-----ISD 214
             L     +    L +L L  N L        +  P L  L  +R  +   C     +  
Sbjct: 291 DTLP--PLQGPGQLRRLRLQGNPLWC----GCQARPLLEWLARARVRSDGACQGPRRLRG 344

Query: 215 FSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLR--------ENKLLHFPDLAA-LP 265
            +L  LR  DL C    A +     +          R        E  +   P     +P
Sbjct: 345 EALDALRPWDLRCPGDAAQEEEELEERAVAGPRAPPRGPPRGPGEERAVAPCPRACVCVP 404

Query: 266 RLIYLNLSN-NLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSY 324
              + +     L  +P G P D++ +      + ++P +A  G      L  L++L L +
Sbjct: 405 ESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPG------LGHLVSLHLQH 458

Query: 325 NEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNA-LETLELGAR 383
             I  +    L  L  L +L LS N L    A  L   P L  L L  N  L+      R
Sbjct: 459 CGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQVPGAALR 518

Query: 384 ALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGIT 443
           AL SL +L LQ NA+  L P       +L+ + L GNR++              A     
Sbjct: 519 ALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVS---------LGALGPAR 569

Query: 444 SLRSLSLVDNEIELLRAGAFLHTP-LTELDLSSNPGLEVATGALGGLEASLEVLALQGNG 502
            L  L L  N++  +  GA    P L EL LS NP   +  GA   +  SL+ L L  +G
Sbjct: 570 ELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSG 629

Query: 503 LMVLQVDLPCFICL----KRLNLAENRLSHLPAWTQAVSLEVLDLRNNSF 548
           L   Q+    F  L    + L+L +N+L  LPA      LE++DL +N F
Sbjct: 630 LE--QICPGAFSGLGPGLQSLHLQKNQLRALPALPSLSQLELIDLSSNPF 677



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 147/548 (26%), Positives = 212/548 (38%), Gaps = 98/548 (17%)

Query: 54  LDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMA- 112
           L LS N L  +    L    ALR L L  NE+  L          L  L L HN L  A 
Sbjct: 187 LRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAG 246

Query: 113 -----------TALSAGG----LGP-----LPRVTSLDLSGNSLYS-------GLLERLL 145
                        L  GG    LGP      PR+ +LDL GN L +       G L RL 
Sbjct: 247 EEDGLALPGLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPPLQGPGQLRRLR 306

Query: 146 GEAPSLHTLSLAENSLTRLTRHTFRD--------------MPALEQLDLH-----SNVLM 186
            +   L     A   L  L R   R               + AL   DL      +    
Sbjct: 307 LQGNPLWCGCQARPLLEWLARARVRSDGACQGPRRLRGEALDALRPWDLRCPGDAAQEEE 366

Query: 187 DIEDGAFEGLPRLTHLNLSRN--SLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQ---A 241
           ++E+ A  G PR       R       ++      + V +   +S E     + P+   +
Sbjct: 367 ELEERAVAG-PRAPPRGPPRGPGEERAVAPCPRACVCVPESRHSSCEGCGLQAVPRGFPS 425

Query: 242 EFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALP 301
           + QL  LDLR N   HFP   ++PR  +  L + +             +H    G + L 
Sbjct: 426 DTQL--LDLRRN---HFP---SVPRAAFPGLGHLV------------SLHLQHCGIAELE 465

Query: 302 LSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGS 361
             A +G      L +L+ L LS N++  +  + LE    L +L L RN         L +
Sbjct: 466 AGALAG------LGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQVPGAALRA 519

Query: 362 LPCLMLLDLSHNALETLELG-ARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGN 420
           LP L  L L  NA++ L  G      +LR + L GN + ++          L++L+L  N
Sbjct: 520 LPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRN 579

Query: 421 RVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAF--LHTPLTELDLSSNPG 478
           ++          P+G  A  G+ +L  L L  N +  LR GAF  +   L  L L+S+  
Sbjct: 580 QLREV-------PTG--ALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGL 630

Query: 479 LEVATGALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNLAEN------RLSHLPAW 532
            ++  GA  GL   L+ L LQ N L  L   LP    L+ ++L+ N      +L  L  W
Sbjct: 631 EQICPGAFSGLGPGLQSLHLQKNQLRALPA-LPSLSQLELIDLSSNPFHCDCQLLPLHRW 689

Query: 533 TQAVSLEV 540
              ++L V
Sbjct: 690 LTGLNLRV 697


>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
           isoform 2 [Homo sapiens]
          Length = 1119

 Score =  101 bits (251), Expect = 3e-21
 Identities = 122/447 (27%), Positives = 188/447 (42%), Gaps = 56/447 (12%)

Query: 15  GLAAQHQDKVPCKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTA 74
           G+AA+      C+ +   + C    L ++P  LP     LDLS N+L  I AS +    +
Sbjct: 40  GVAAERPCPTTCRCLGDLLDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQS 99

Query: 75  LRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLP-RVTSLDLSG 133
           LR + L+ NE+  +                               LGP+   +T L L+G
Sbjct: 100 LREVKLNNNELETIP-----------------------------NLGPVSANITLLSLAG 130

Query: 134 NSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAF 193
           N +   L E L  E  SL TL L+ N+++ L   T      L+ L L+SN +  +E G F
Sbjct: 131 NRIVEILPEHLK-EFQSLETLDLSSNNISEL--QTAFPALQLKYLYLNSNRVTSMEPGYF 187

Query: 194 EGLPR-LTHLNLSRNSLTCISD--FSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDL 250
           + L   L  L L+RN ++ I    F L QL+ L+L+ N I+     +  Q    L  L +
Sbjct: 188 DNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTF-QGLGALKSLKM 246

Query: 251 RENKLLHFPDLA--ALPRLIYLNLS-NNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSG 307
           + N +    D A   L  +  L L  NNL  +  G       +       +A+   +P  
Sbjct: 247 QRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDA 306

Query: 308 NASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLML 367
               + LS+L   DL++N +  + DS    L+ L  L++  N +          L  L  
Sbjct: 307 WEFCQKLSEL---DLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKT 363

Query: 368 LDLSHN----ALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVS 423
           LDL +N     +E +      L  LR L+LQGN +R +    F  L +L+ L+L  N + 
Sbjct: 364 LDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIM 423

Query: 424 PCGGPDEPGPSGCVAFSGITSLRSLSL 450
              G          AFS +  L+ L L
Sbjct: 424 SLQGN---------AFSQMKKLQQLHL 441



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 122/457 (26%), Positives = 191/457 (41%), Gaps = 82/457 (17%)

Query: 141 LERLLGEAPS-LHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIED-GAFEGLPR 198
           L RL    PS +  L L+ N L+ +   +   + +L ++ L++N L  I + G       
Sbjct: 65  LARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSA--N 122

Query: 199 LTHLNLSRNSLTCISDFSL---QQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKL 255
           +T L+L+ N +  I    L   Q L  LDLS N+I   QTA       QL +L L  N++
Sbjct: 123 ITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPA---LQLKYLYLNSNRV 179

Query: 256 L-----HFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNAS 310
                 +F +LA    L+ L L+ N  R+   PP+  K                      
Sbjct: 180 TSMEPGYFDNLANT--LLVLKLNRN--RISAIPPKMFK---------------------- 213

Query: 311 GRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDL 370
              L QL +L+L+ N+I+ +     + L +L  L + RN +          L  + +L L
Sbjct: 214 ---LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQL 270

Query: 371 SHNALETLELG-ARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPD 429
            HN L  +  G    L  L+ L L  NA+  + P  +     L  L+L  N +S      
Sbjct: 271 DHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDS- 329

Query: 430 EPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLH-TPLTELDLSSNP---GLEVATGA 485
                   +F G++ L +L + +N +  +   AF   + L  LDL +N     +E   GA
Sbjct: 330 --------SFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGA 381

Query: 486 LGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEVLDLRN 545
             GL+  L  L LQGN +                     R     A+T   +LE LDL +
Sbjct: 382 FSGLD-KLRRLILQGNRI---------------------RSITKKAFTGLDALEHLDLSD 419

Query: 546 NSFSLLPGSAMGGLETSLRRLYLQGNPLSC-CGNGWL 581
           N+   L G+A   ++  L++L+L  + L C C   WL
Sbjct: 420 NAIMSLQGNAFSQMK-KLQQLHLNTSSLLCDCQLKWL 455



 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 51/163 (31%), Positives = 78/163 (47%), Gaps = 7/163 (4%)

Query: 52  ETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAM 111
           + L LS N +  I      F   L  LDL+ N +S L   +F  L+ L  L + +NR++ 
Sbjct: 290 QELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSY 349

Query: 112 ATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGE---APSLHTLSLAENSLTRLTRHT 168
               +  GL  L    +LDL  N + S  +E + G       L  L L  N +  +T+  
Sbjct: 350 IADCAFRGLSSLK---TLDLKNNEI-SWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKA 405

Query: 169 FRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTC 211
           F  + ALE LDL  N +M ++  AF  + +L  L+L+ +SL C
Sbjct: 406 FTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLC 448



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 84/348 (24%), Positives = 140/348 (40%), Gaps = 58/348 (16%)

Query: 302 LSAPSGNASGRPLSQLLN-----LDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEA 356
           L  PSG A+ RP           LD S   +  +P+     +  L   +LS N L   +A
Sbjct: 35  LGQPSGVAAERPCPTTCRCLGDLLDCSRKRLARLPEPLPSWVARL---DLSHNRLSFIKA 91

Query: 357 RRLGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLN 416
             +  L  L  + L++N LET+        ++  L L GN + ++ P       SL+ L+
Sbjct: 92  SSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLD 151

Query: 417 LQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSN 476
           L  N +S                              E++     AF    L  L L+SN
Sbjct: 152 LSSNNIS------------------------------ELQT----AFPALQLKYLYLNSN 177

Query: 477 PGLEVATGALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWT-QA 535
               +  G    L  +L VL L  N +  +   +     L+ L L  N++ ++   T Q 
Sbjct: 178 RVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQG 237

Query: 536 V-SLEVLDLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLSCCGNGWL-----AAQLHQ-- 587
           + +L+ L ++ N  + L   A  GL +++  L L  N L+    GWL       +LH   
Sbjct: 238 LGALKSLKMQRNGVTKLMDGAFWGL-SNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQ 296

Query: 588 ---GRVDVDATQDLICRFSSQEEVSLSHV-RPEDCEKGGLKNINLIII 631
               R+  DA +   C+  S+ +++ +H+ R +D    GL  +N + I
Sbjct: 297 NAINRISPDAWE--FCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHI 342


>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
          Length = 560

 Score =  101 bits (251), Expect = 3e-21
 Identities = 102/339 (30%), Positives = 145/339 (42%), Gaps = 33/339 (9%)

Query: 52  ETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAM 111
           +TL LS N++  +  + L     L  L L  N +  +    FQ L +L+ L+L  N+L  
Sbjct: 101 KTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDF 160

Query: 112 ATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRD 171
              L A     L  +  LDLSGN+L + L + LLG    L  L L  N L  L       
Sbjct: 161 ---LPASLFTNLENLKLLDLSGNNL-THLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNS 216

Query: 172 MPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIE 231
           + AL +L  H N +  I  GAF+ LP L+ L LSRN L  +          L L  +++ 
Sbjct: 217 LGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPS-------ALFLHSHNLT 269

Query: 232 AFQTASQPQAE-----------FQLTWLDLRENKLLHFPDLAALPRLIYL--NLSNNLIR 278
                  P AE            Q  WL+  + + L       L RL YL   LS  L  
Sbjct: 270 LLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSA 329

Query: 279 LPTGPPQ---DSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFL 335
           LP G  Q   + + +   S G +ALP      +   R L +L  + L  N +  +P +  
Sbjct: 330 LPQGAFQGLGELQVLALHSNGLTALP------DGLLRGLGKLRQVSLRRNRLRALPRALF 383

Query: 336 EHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNA 374
            +L+SL  + L  N L T      G+LP L  + L HN+
Sbjct: 384 RNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNS 422



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 121/428 (28%), Positives = 176/428 (41%), Gaps = 71/428 (16%)

Query: 195 GLP-RLTHL---NLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDL 250
           GLP  LTH+    + R  L   S   +  L+ L +S + I A    +      +L  L L
Sbjct: 47  GLPTNLTHILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDL-IKLKTLRL 105

Query: 251 RENKLLHFPDLAALPRLIYLN---LSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSG 307
             NK+ H P  A L +++ L    L +N +R   G  Q+                     
Sbjct: 106 SRNKITHLPG-ALLDKMVLLEQLFLDHNALR---GIDQNMF------------------- 142

Query: 308 NASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLML 367
               + L  L  L L+ N+++ +P S   +L +L  L+LS N L       LG+   L  
Sbjct: 143 ----QKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLER 198

Query: 368 LDLSHNALETLELGA-RALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCG 426
           L L  N L +L+ G   +LG+L  L    N +R + P  F  L +L  L L  N ++   
Sbjct: 199 LLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLP 258

Query: 427 GP-------------------DEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLH-T 466
                                + PG    V F  +  L+ L L   ++  L A AF + +
Sbjct: 259 SALFLHSHNLTLLTLFENPLAELPG----VLFGEMGGLQELWLNRTQLRTLPAAAFRNLS 314

Query: 467 PLTELDLSSNPGLE-VATGALGGLEASLEVLALQGNGLMVLQVDLPCFIC-LKRLNLAEN 524
            L  L ++ +P L  +  GA  GL   L+VLAL  NGL  L   L   +  L++++L  N
Sbjct: 315 RLRYLGVTLSPRLSALPQGAFQGL-GELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRN 373

Query: 525 RLSHLPA--WTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLSC-CG---- 577
           RL  LP   +    SLE + L +N    LPG   G L   L  + L  N   C CG    
Sbjct: 374 RLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGAL-PRLTEVLLGHNSWRCDCGLGPF 432

Query: 578 NGWLAAQL 585
            GWL   L
Sbjct: 433 LGWLRQHL 440



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 95/359 (26%), Positives = 141/359 (39%), Gaps = 46/359 (12%)

Query: 151 LHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLT 210
           L  L ++++ ++ +   TF D+  L+ L L  N +  +     + +  L  L L  N+L 
Sbjct: 76  LQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALR 135

Query: 211 CISDFSLQQ---LRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPD--LAALP 265
            I     Q+   L+ L L+ N ++ F  AS       L  LDL  N L H P   L A  
Sbjct: 136 GIDQNMFQKLVNLQELALNQNQLD-FLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQA 194

Query: 266 RLIYLNL-SNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSY 324
           +L  L L SN L+ L +G       +       + +   AP   A  R L  L +L LS 
Sbjct: 195 KLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAP--GAFDR-LPNLSSLTLSR 251

Query: 325 NEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGA-- 382
           N +  +P +   H  +L  L L  N L        G +  L  L L+   L TL   A  
Sbjct: 252 NHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFR 311

Query: 383 ------------------------RALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQ 418
                                   + LG L+ L L  N L  LP      L  L++++L+
Sbjct: 312 NLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLR 371

Query: 419 GNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTP-LTELDLSSN 476
            NR+                F  ++SL S+ L  N++E L    F   P LTE+ L  N
Sbjct: 372 RNRLRALPR---------ALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHN 421



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 49/158 (31%), Positives = 70/158 (44%), Gaps = 3/158 (1%)

Query: 54  LDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMAT 113
           L L  N L  +     G    L+ L L+  ++  L   AF+ L+ L +L +  +     +
Sbjct: 271 LTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLS--PRLS 328

Query: 114 ALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMP 173
           AL  G    L  +  L L  N L + L + LL     L  +SL  N L  L R  FR++ 
Sbjct: 329 ALPQGAFQGLGELQVLALHSNGL-TALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLS 387

Query: 174 ALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTC 211
           +LE + L  N L  +    F  LPRLT + L  NS  C
Sbjct: 388 SLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNSWRC 425


>gi|188528675 slit homolog 1 [Homo sapiens]
          Length = 1534

 Score = 97.8 bits (242), Expect = 3e-20
 Identities = 127/495 (25%), Positives = 194/495 (39%), Gaps = 86/495 (17%)

Query: 1   MRPQILLLLALLTLGLAAQHQDKVPCKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQ 60
           +RP++ LLL      L A     + C      V C   GL  +P  +P +TE L+L+GN 
Sbjct: 14  VRPELWLLLWAAAWRLGASACPAL-CTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNN 72

Query: 61  LRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGL 120
           +  I                            F  L  L  L L  N++    A+  G  
Sbjct: 73  ITRI------------------------HKNDFAGLKQLRVLQLMENQIG---AVERGAF 105

Query: 121 GPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDL 180
             +  +  L L+ N L+  +L  LL                       F++  AL +LDL
Sbjct: 106 DDMKELERLRLNRNQLH--MLPELL-----------------------FQNNQALSRLDL 140

Query: 181 HSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLR---VLDLSCNSIEAFQTAS 237
             N +  I   AF G   L +L L +N ++CI + + + LR   VL L+ N+I     +S
Sbjct: 141 SENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSS 200

Query: 238 QPQAEFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGW 297
                 +L    L  N L     LA L + +    +  L    +G P   +G++      
Sbjct: 201 FNHMP-KLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSG-PASLRGLNVAEVQK 258

Query: 298 SALPLSAPSGNASGRPLSQLLN-------------LDLSYNEIELIPDSFLEHLTSLCFL 344
           S    S   G A   P   L +             +D     +  IP +  E +T    +
Sbjct: 259 SEFSCSG-QGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIPANLPETMTE---I 314

Query: 345 NLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGA-RALGSLRTLLLQGNALRDLPP 403
            L  N +++           L  +DLS+N +  +   A + L SL +L+L GN + DLP 
Sbjct: 315 RLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPR 374

Query: 404 YTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAF 463
             F  L +LQ L L  N+++ C  PD        AF  + +L  LSL DN+I+ L  G F
Sbjct: 375 GVFGGLYTLQLLLLNANKIN-CIRPD--------AFQDLQNLSLLSLYDNKIQSLAKGTF 425

Query: 464 LH-TPLTELDLSSNP 477
                +  L L+ NP
Sbjct: 426 TSLRAIQTLHLAQNP 440



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 112/437 (25%), Positives = 181/437 (41%), Gaps = 60/437 (13%)

Query: 26  CKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEI 85
           C   +  V C+  GL  +P+ LP     + L  N ++SI       Y  LR +DLS N+I
Sbjct: 286 CTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQI 345

Query: 86  SFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLL 145
           + + P AFQ L  L  L L  N++             LPR          ++ GL     
Sbjct: 346 AEIAPDAFQGLRSLNSLVLYGNKIT-----------DLPR---------GVFGGLY---- 381

Query: 146 GEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLS 205
               +L  L L  N +  +    F+D+  L  L L+ N +  +  G F  L  +  L+L+
Sbjct: 382 ----TLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLA 437

Query: 206 RNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPDLAALP 265
           +N   C  D +L+ L    L  N IE   + ++  +  +L    + + K   F   A   
Sbjct: 438 QNPFIC--DCNLKWLADF-LRTNPIET--SGARCASPRRLANKRIGQIKSKKFRCSAKEQ 492

Query: 266 RLI------YLNLS-NNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLL 318
             I       LN   N+ +  P     ++  +   S   + +P   P   A         
Sbjct: 493 YFIPGTEDYQLNSECNSDVVCPHKCRCEANVVECSSLKLTKIPERIPQSTA--------- 543

Query: 319 NLDLSYNEIELI-PDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALET 377
            L L+ NEI ++      + LT L  +NLS N +   E         +  L L+ N LE+
Sbjct: 544 ELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLES 603

Query: 378 LELGA-RALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGC 436
           +  G  R L  LRTL+L+ N +  +   +F  L +++ L+L  N+++       PG    
Sbjct: 604 IRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTV----SPG---- 655

Query: 437 VAFSGITSLRSLSLVDN 453
            AF  + SL +L+L+ N
Sbjct: 656 -AFDTLQSLSTLNLLAN 671



 Score = 81.3 bits (199), Expect = 3e-15
 Identities = 107/436 (24%), Positives = 171/436 (39%), Gaps = 90/436 (20%)

Query: 26  CKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHL---DLST 82
           C+     V C  L L ++P  +P  T  L L+ N++  + A+  G +  L HL   +LS 
Sbjct: 517 CRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEAT--GMFKKLTHLKKINLSN 574

Query: 83  NEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLE 142
           N++S ++ GAF+    +  L L  N+L                         S+ SG+  
Sbjct: 575 NKVSEIEDGAFEGAASVSELHLTANQL------------------------ESIRSGMFR 610

Query: 143 RLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHL 202
            L G    L TL L  N ++ +   +F  +  +  L L+ N +  +  GAF+ L  L+ L
Sbjct: 611 GLDG----LRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTL 666

Query: 203 NLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLD--LRENKLLHFPD 260
           NL  N                  +CN               QL WL   LR+ K++    
Sbjct: 667 NLLANPF----------------NCNC--------------QLAWLGGWLRKRKIVTGNP 696

Query: 261 LAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNL 320
               P  +        I L      D +      EG        P   A    + +  N 
Sbjct: 697 RCQNPDFL------RQIPLQDVAFPDFRCEEGQEEGGCLPRPQCPQECACLDTVVRCSN- 749

Query: 321 DLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLEL 380
                 +  +P    +++T L    L  N   T    +L +   L L+DLS+N + +L  
Sbjct: 750 ----KHLRALPKGIPKNVTELY---LDGNQF-TLVPGQLSTFKYLQLVDLSNNKISSLSN 801

Query: 381 GARA-LGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAF 439
            +   +  L TL+L  NAL+ +PP  F  L SL+ L+L GN +S      + G      F
Sbjct: 802 SSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTL----QEG-----IF 852

Query: 440 SGITSLRSLSLVDNEI 455
           + +TSL  L++  N +
Sbjct: 853 ADVTSLSHLAIGANPL 868



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 108/430 (25%), Positives = 174/430 (40%), Gaps = 69/430 (16%)

Query: 62  RSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLG 121
           + + A P      +  + L  N I  + PGAF     L  + L++N++A     +  GL 
Sbjct: 298 KGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLR 357

Query: 122 PLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLH 181
                                       SL++L L  N +T L R  F  +  L+ L L+
Sbjct: 358 ----------------------------SLNSLVLYGNKITDLPRGVFGGLYTLQLLLLN 389

Query: 182 SNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQ- 240
           +N +  I   AF+ L  L+ L+L  N +  ++  +   LR       +I+    A  P  
Sbjct: 390 ANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLR-------AIQTLHLAQNPFI 442

Query: 241 AEFQLTWLD--LRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSE--- 295
            +  L WL   LR N +       A PR     L+N  I    G  +  K   +  E   
Sbjct: 443 CDCNLKWLADFLRTNPIETSGARCASPR----RLANKRI----GQIKSKKFRCSAKEQYF 494

Query: 296 --GWSALPLSAPSGNASGRPLS---QLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNC 350
             G     L++   +    P     +   ++ S  ++  IP+   +   S   L L+ N 
Sbjct: 495 IPGTEDYQLNSECNSDVVCPHKCRCEANVVECSSLKLTKIPERIPQ---STAELRLNNNE 551

Query: 351 LRTFEARRL-GSLPCLMLLDLSHNALETLELGA-RALGSLRTLLLQGNALRDLPPYTFAN 408
           +   EA  +   L  L  ++LS+N +  +E GA     S+  L L  N L  +    F  
Sbjct: 552 ISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRG 611

Query: 409 LASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAF-LHTP 467
           L  L+ L L+ NR+S C   D        +F+G+ ++R LSL DN+I  +  GAF     
Sbjct: 612 LDGLRTLMLRNNRIS-CIHND--------SFTGLRNVRLLSLYDNQITTVSPGAFDTLQS 662

Query: 468 LTELDLSSNP 477
           L+ L+L +NP
Sbjct: 663 LSTLNLLANP 672



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 125/467 (26%), Positives = 181/467 (38%), Gaps = 94/467 (20%)

Query: 178 LDLHSNVLMDIEDGAFEGLPRLTH-LNLSRNSLTCI--SDFS-LQQLRVLDLSCNSIEAF 233
           +D H   L  I     + +PR T  L L+ N++T I  +DF+ L+QLRVL L  N I A 
Sbjct: 45  VDCHGTGLQAIP----KNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAV 100

Query: 234 QTASQPQAEFQLTWLDLRENKLLHFPDLA-----ALPRLIYLNLSNNLIRLPTGPPQDSK 288
           +  +    + +L  L L  N+L   P+L      AL RL   +LS N I+          
Sbjct: 101 ERGAFDDMK-ELERLRLNRNQLHMLPELLFQNNQALSRL---DLSENAIQ---------- 146

Query: 289 GIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSR 348
                     A+P  A  G       + L NL L  N+I  I +     L  L  L L+ 
Sbjct: 147 ----------AIPRKAFRG------ATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNN 190

Query: 349 NCLRTFEARRLGSLPCLMLLDLSHNALE--------TLELGARALGSLRTLLLQGNALRD 400
           N + T        +P L    L  N L         +  L  R    L T      +LR 
Sbjct: 191 NNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPASLRG 250

Query: 401 LPPYTFANLASLQRLNL------QGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVD-- 452
           L      N+A +Q+         +  RV  C       P+ C   +GI   R   L    
Sbjct: 251 L------NVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIP 304

Query: 453 --------------NEIELLRAGAFL-HTPLTELDLSSNPGLEVATGALGGLEASLEVLA 497
                         N I+ +  GAF  +  L  +DLS+N   E+A  A  GL  SL  L 
Sbjct: 305 ANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLR-SLNSLV 363

Query: 498 LQGNGLMVLQVDLPCFI-----CLKRLNLAENRLSHL--PAWTQAVSLEVLDLRNNSFSL 550
           L GN +     DLP  +      L+ L L  N+++ +   A+    +L +L L +N    
Sbjct: 364 LYGNKI----TDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQS 419

Query: 551 LPGSAMGGLETSLRRLYLQGNPLSC-CGNGWLAAQLHQGRVDVDATQ 596
           L       L  +++ L+L  NP  C C   WLA  L    ++    +
Sbjct: 420 LAKGTFTSLR-AIQTLHLAQNPFICDCNLKWLADFLRTNPIETSGAR 465



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 64/218 (29%), Positives = 94/218 (43%), Gaps = 24/218 (11%)

Query: 380 LGARALGSL-----RTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPS 434
           LGA A  +L      T+   G  L+ +P     N    +RL L GN ++     D     
Sbjct: 29  LGASACPALCTCTGTTVDCHGTGLQAIPKNIPRNT---ERLELNGNNITRIHKND----- 80

Query: 435 GCVAFSGITSLRSLSLVDNEIELLRAGAFLHTP-LTELDLSSNPGLEVATGALGGLEASL 493
               F+G+  LR L L++N+I  +  GAF     L  L L+ N  L +    L     +L
Sbjct: 81  ----FAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQ-LHMLPELLFQNNQAL 135

Query: 494 EVLALQGNGLMVL-QVDLPCFICLKRLNLAENRLSHLP--AWTQAVSLEVLDLRNNSFSL 550
             L L  N +  + +        LK L L +N++S +   A+     LEVL L NN+ + 
Sbjct: 136 SRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITT 195

Query: 551 LPGSAMGGLETSLRRLYLQGNPLSC-CGNGWLAAQLHQ 587
           +P S+   +   LR   L  N L C C   WL+  L Q
Sbjct: 196 IPVSSFNHM-PKLRTFRLHSNHLFCDCHLAWLSQWLRQ 232



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 29/97 (29%), Positives = 45/97 (46%), Gaps = 1/97 (1%)

Query: 115 LSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPA 174
           L  G L     +  +DLS N + S L          L TL L+ N+L  +    F+ + +
Sbjct: 775 LVPGQLSTFKYLQLVDLSNNKI-SSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRS 833

Query: 175 LEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTC 211
           L  L LH N +  +++G F  +  L+HL +  N L C
Sbjct: 834 LRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPLYC 870



 Score = 36.6 bits (83), Expect = 0.076
 Identities = 27/86 (31%), Positives = 41/86 (47%), Gaps = 3/86 (3%)

Query: 52  ETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAM 111
           + +DLS N++ S+  S     + L  L LS N +  + P AFQ L  L  LSL  N +  
Sbjct: 787 QLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDI-- 844

Query: 112 ATALSAGGLGPLPRVTSLDLSGNSLY 137
            + L  G    +  ++ L +  N LY
Sbjct: 845 -STLQEGIFADVTSLSHLAIGANPLY 869


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.137    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,558,479
Number of Sequences: 37866
Number of extensions: 1174838
Number of successful extensions: 7400
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 225
Number of HSP's successfully gapped in prelim test: 105
Number of HSP's that attempted gapping in prelim test: 3443
Number of HSP's gapped (non-prelim): 1668
length of query: 662
length of database: 18,247,518
effective HSP length: 109
effective length of query: 553
effective length of database: 14,120,124
effective search space: 7808428572
effective search space used: 7808428572
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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