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Search of human proteins with 191252816
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|191252816 extracellular leucine-rich repeat and fibronectin
type III domain containing 1 [Homo sapiens]
(828 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|191252816 extracellular leucine-rich repeat and fibronectin t... 1680 0.0
gi|116268101 leucine rich repeat containing 62 [Homo sapiens] 697 0.0
gi|188528675 slit homolog 1 [Homo sapiens] 96 1e-19
gi|109150416 peroxidasin [Homo sapiens] 93 9e-19
gi|11321571 slit homolog 3 [Homo sapiens] 93 9e-19
gi|40217820 slit and trk like 3 protein [Homo sapiens] 93 1e-18
gi|4759146 slit homolog 2 [Homo sapiens] 89 1e-17
gi|194306623 immunoglobulin superfamily containing leucine-rich ... 89 1e-17
gi|194306621 immunoglobulin superfamily containing leucine-rich ... 89 1e-17
gi|39930401 immunoglobulin superfamily containing leucine-rich r... 89 1e-17
gi|194306618 immunoglobulin superfamily containing leucine-rich ... 89 1e-17
gi|126517478 peroxidasin homolog-like [Homo sapiens] 86 1e-16
gi|40217823 SLIT and NTRK-like family, member 5 [Homo sapiens] 85 2e-16
gi|40217825 slit and trk like 6 [Homo sapiens] 83 9e-16
gi|4758460 glycoprotein V (platelet) [Homo sapiens] 82 2e-15
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 81 3e-15
gi|209862903 leucine-rich repeats and immunoglobulin-like domain... 81 3e-15
gi|13375646 leucine rich repeat and fibronectin type III domain ... 81 5e-15
gi|27436867 slit and trk like 4 protein [Homo sapiens] 80 8e-15
gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo sa... 80 1e-14
gi|84781739 leucine-rich repeats and transmembrane domains 2 [Ho... 79 1e-14
gi|41582239 immunoglobulin superfamily containing leucine-rich r... 78 3e-14
gi|5031809 immunoglobulin superfamily containing leucine-rich re... 78 3e-14
gi|51317373 netrin-G1 ligand [Homo sapiens] 78 4e-14
gi|10190722 leucine-rich repeats and transmembrane domains 1 [Ho... 78 4e-14
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 77 7e-14
gi|239752702 PREDICTED: leucine rich repeat containing 38, parti... 77 9e-14
gi|239747236 PREDICTED: leucine rich repeat containing 38 [Homo ... 77 9e-14
gi|239741057 PREDICTED: leucine rich repeat containing 38 [Homo ... 77 9e-14
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 77 9e-14
>gi|191252816 extracellular leucine-rich repeat and fibronectin type
III domain containing 1 [Homo sapiens]
Length = 828
Score = 1680 bits (4351), Expect = 0.0
Identities = 828/828 (100%), Positives = 828/828 (100%)
Query: 1 MAGRGWGALWVCVAAATLLHAGGLARADCWLIEGDKGFVWLAICSQNQPPYEAIPQQINS 60
MAGRGWGALWVCVAAATLLHAGGLARADCWLIEGDKGFVWLAICSQNQPPYEAIPQQINS
Sbjct: 1 MAGRGWGALWVCVAAATLLHAGGLARADCWLIEGDKGFVWLAICSQNQPPYEAIPQQINS 60
Query: 61 TIVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRL 120
TIVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRL
Sbjct: 61 TIVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRL 120
Query: 121 RNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLNSGTFAGLA 180
RNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLNSGTFAGLA
Sbjct: 121 RNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLNSGTFAGLA 180
Query: 181 KLSVCELYSNPFYCSCELLGFLRWLAAFTNATQTYDRMQCESPPVYSGYYLLGQGRRGHR 240
KLSVCELYSNPFYCSCELLGFLRWLAAFTNATQTYDRMQCESPPVYSGYYLLGQGRRGHR
Sbjct: 181 KLSVCELYSNPFYCSCELLGFLRWLAAFTNATQTYDRMQCESPPVYSGYYLLGQGRRGHR 240
Query: 241 SILSKLQSVCTEDSYAAEVVGPPRPASGRSQPGRSPPPPPPPEPSDMPCADDECFSGDGT 300
SILSKLQSVCTEDSYAAEVVGPPRPASGRSQPGRSPPPPPPPEPSDMPCADDECFSGDGT
Sbjct: 241 SILSKLQSVCTEDSYAAEVVGPPRPASGRSQPGRSPPPPPPPEPSDMPCADDECFSGDGT 300
Query: 301 TPLVALPTLATQAEARPLIKVKQLTQNSATITVQLPSPFHRMYTLEHFNNSKASTVSRLT 360
TPLVALPTLATQAEARPLIKVKQLTQNSATITVQLPSPFHRMYTLEHFNNSKASTVSRLT
Sbjct: 301 TPLVALPTLATQAEARPLIKVKQLTQNSATITVQLPSPFHRMYTLEHFNNSKASTVSRLT 360
Query: 361 KAQEEIRLTNLFTLTNYTYCVVSTSAGLRHNHTCLTICLPRLPSPPGPVPSPSTATHYIM 420
KAQEEIRLTNLFTLTNYTYCVVSTSAGLRHNHTCLTICLPRLPSPPGPVPSPSTATHYIM
Sbjct: 361 KAQEEIRLTNLFTLTNYTYCVVSTSAGLRHNHTCLTICLPRLPSPPGPVPSPSTATHYIM 420
Query: 421 TILGCLFGMVLVLGAVYYCLRRRRRQEEKHKKAASAAAAGSLKKTIIELKYGPELEAPGL 480
TILGCLFGMVLVLGAVYYCLRRRRRQEEKHKKAASAAAAGSLKKTIIELKYGPELEAPGL
Sbjct: 421 TILGCLFGMVLVLGAVYYCLRRRRRQEEKHKKAASAAAAGSLKKTIIELKYGPELEAPGL 480
Query: 481 APLSQGPLLGPEAVTRIPYLPAAGEVEQYKLVESADTPKASKGSYMEVRTGDPPERRDCE 540
APLSQGPLLGPEAVTRIPYLPAAGEVEQYKLVESADTPKASKGSYMEVRTGDPPERRDCE
Sbjct: 481 APLSQGPLLGPEAVTRIPYLPAAGEVEQYKLVESADTPKASKGSYMEVRTGDPPERRDCE 540
Query: 541 LGRPGPDSQSSVAEISTIAKEVDKVNQIINNCIDALKSESTSFQGVKSGPVSVAEPPLVL 600
LGRPGPDSQSSVAEISTIAKEVDKVNQIINNCIDALKSESTSFQGVKSGPVSVAEPPLVL
Sbjct: 541 LGRPGPDSQSSVAEISTIAKEVDKVNQIINNCIDALKSESTSFQGVKSGPVSVAEPPLVL 600
Query: 601 LSEPLAAKHGFLAPGYKDAFGHSLQRHHSVEAAGPPRASTSSSGSVRSPRAFRAEAVGVH 660
LSEPLAAKHGFLAPGYKDAFGHSLQRHHSVEAAGPPRASTSSSGSVRSPRAFRAEAVGVH
Sbjct: 601 LSEPLAAKHGFLAPGYKDAFGHSLQRHHSVEAAGPPRASTSSSGSVRSPRAFRAEAVGVH 660
Query: 661 KAAAAEAKYIEKGSPAADAILTVTPAAAVLRAEAEKGRQYGEHRHSYPGSHPAEPPAPPG 720
KAAAAEAKYIEKGSPAADAILTVTPAAAVLRAEAEKGRQYGEHRHSYPGSHPAEPPAPPG
Sbjct: 661 KAAAAEAKYIEKGSPAADAILTVTPAAAVLRAEAEKGRQYGEHRHSYPGSHPAEPPAPPG 720
Query: 721 PPPPPPHEGLGRKASILEPLTRPRPRDLAYSQLSPQYHSLSYSSSPEYTCRASQSIWERF 780
PPPPPPHEGLGRKASILEPLTRPRPRDLAYSQLSPQYHSLSYSSSPEYTCRASQSIWERF
Sbjct: 721 PPPPPPHEGLGRKASILEPLTRPRPRDLAYSQLSPQYHSLSYSSSPEYTCRASQSIWERF 780
Query: 781 RLSRRRHKEEEEFMAAGHALRKKVQFAKDEDLHDILDYWKGVSAQHKS 828
RLSRRRHKEEEEFMAAGHALRKKVQFAKDEDLHDILDYWKGVSAQHKS
Sbjct: 781 RLSRRRHKEEEEFMAAGHALRKKVQFAKDEDLHDILDYWKGVSAQHKS 828
>gi|116268101 leucine rich repeat containing 62 [Homo sapiens]
Length = 820
Score = 697 bits (1799), Expect = 0.0
Identities = 413/860 (48%), Positives = 521/860 (60%), Gaps = 85/860 (9%)
Query: 9 LWVCVAAATLLHAGGLARADCWLIEGDKGFVWLAICSQNQPPYEAIPQQINSTIVDLRLN 68
L +C AA + G RADCWLIEGDKG+VWLAICSQNQPPYE IPQ INST+ DLRLN
Sbjct: 4 LGLCAAALLCVCRPGAVRADCWLIEGDKGYVWLAICSQNQPPYETIPQHINSTVHDLRLN 63
Query: 69 ENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRLRNLTEGML 128
EN++++V Y+SL+RFGNLT LNLTKNEI YIEDGAF GQ +LQVLQLGYN+L NLTEGML
Sbjct: 64 ENKLKAVLYSSLNRFGNLTDLNLTKNEISYIEDGAFLGQSSLQVLQLGYNKLSNLTEGML 123
Query: 129 RGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLNSGTFAGLAKLSVCELY 188
RG+ +L++L++Q NLIEVV ++F ECP++++IDLS NR+ +L+ TFA LA L VCEL
Sbjct: 124 RGMSRLQFLFVQHNLIEVVTPTAFSECPSLISIDLSSNRLSRLDGATFASLASLMVCELA 183
Query: 189 SNPFYCSCELLGFLRWLAAFTNATQTYDRMQCESPPVYSGYYLLGQGRRGHRSILSKLQS 248
NPF C C+L GFL WL F N T+ YDR+QCESP ++GY LL + ++ LQ+
Sbjct: 184 GNPFNCECDLFGFLAWLVVFNNVTKNYDRLQCESPREFAGYPLLVPRPYHSLNAITVLQA 243
Query: 249 VCTEDSYAAEVVGPPRPASGRSQPGRSPPPPPPPEPSDMPCADDECFSGDGTTPLVALPT 308
C S A V P P S +Q R P ++ F+ D + +
Sbjct: 244 KCRNGSLPARPVSHPTPYSTDAQ--REPD-------------ENSGFNPDEILSVEPPAS 288
Query: 309 LATQAEARPLIKVKQLTQNSATITVQLPSPFHRMYTLEHFNNSKASTVSRLTKAQEEIRL 368
T A A P IK+ +T SAT+ V +P P+ +MY L +NNS S V L +E + L
Sbjct: 289 STTDASAGPAIKLHHVTFTSATLVVIIPHPYSKMYILVQYNNSYFSDVMTLKNKKEIVTL 348
Query: 369 TNLFTLTNYTYCVVSTSAGLRHNHTCLTICLPRLPSPPGPVPSPSTATHYIMTILGCLFG 428
L T YT+CV S R NHTCLT R P P PS ST THYIMTILGCLFG
Sbjct: 349 DKLRAHTEYTFCVTSLRNSRRFNHTCLTF-TTRDPVPGDLAPSTSTTTHYIMTILGCLFG 407
Query: 429 MVLVLGAVYYCLRRRRRQEEKHKKAASAAAAGSLKKTIIELKYGPELEAPGLA----PLS 484
MV+VLGAVYYCLR+RR QEEK K ++KKTI+E++YG +++A + L
Sbjct: 408 MVIVLGAVYYCLRKRRMQEEKQKSV-------NVKKTILEMRYGADVDAGSIVHAAQKLG 460
Query: 485 QGPLLGPEAVTRIPYLPAAGEVEQYKLVESADTPK-ASKGSYMEVRTGDPPERRDCELGR 543
+ P+L + IP + L DTPK A+KG+Y+EVRTG + L R
Sbjct: 461 EPPVLPVSRMASIPSMIGEKLPTAKGLEAGLDTPKVATKGNYIEVRTGAGGD----GLAR 516
Query: 544 PGPD------SQSSVAEISTIAKEVDKVNQIINNCIDALKSESTSFQGVKSGPVSVAEPP 597
P D Q S AEISTIAKEVDKVNQIINNCIDALK +S SF G G S +P
Sbjct: 517 PEDDLPDLENGQGSAAEISTIAKEVDKVNQIINNCIDALKLDSASFLG---GGSSSGDPE 573
Query: 598 LVLLSEPLAA--------------KHGFLAPGYKDAFGHSLQRHHSVEAAGPPR-ASTSS 642
L + L A + FL+P YK++ H LQR S +AA + S SS
Sbjct: 574 LAFECQSLPAAAAASSATGPGALERPSFLSPPYKESSHHPLQRQLSADAAVTRKTCSVSS 633
Query: 643 SGSVRSPRAFRAEAVGVHKAAA----AEAKYIEKGSPAADAI--LTVTPAAA-------- 688
SGS++S + F + V H AA ++KYIEKGSP + L + PA +
Sbjct: 634 SGSIKSAKVFSLD-VPDHPAATGLAKGDSKYIEKGSPLNSPLDRLPLVPAGSGGGSGGGG 692
Query: 689 -VLRAEAEKGRQYGEHRHSYPGSHPAEPPAPPGPPPPPPHEGLGRKASILEPLTRPRPRD 747
+ E + EHRHS+P + E + L ++ S L+PLTR + RD
Sbjct: 693 GIHHLEVKPAYHCSEHRHSFPALYYEEGA-----------DSLSQRVSFLKPLTRSK-RD 740
Query: 748 LAYSQLSPQYHSLSYSSSPEYTCRASQSIWERFRLSRRRHKEEEEFMAAGHALRKKVQFA 807
YSQLSP+++ YSSSPEY+ ++ IWERFR ++ H+ EE +MAAGHALRKKVQFA
Sbjct: 741 STYSQLSPRHYYSGYSSSPEYSSESTHKIWERFRPYKKHHR-EEVYMAAGHALRKKVQFA 799
Query: 808 KDEDLHDILDYWKGVSAQHK 827
KDEDLHDILDYWKGVSAQ K
Sbjct: 800 KDEDLHDILDYWKGVSAQQK 819
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 95.9 bits (237), Expect = 1e-19
Identities = 60/173 (34%), Positives = 88/173 (50%), Gaps = 7/173 (4%)
Query: 53 AIPQQINSTIVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQV 112
AIP + T+ ++RL N I+S+ + S + L ++L+ N+I I AF G +L
Sbjct: 302 AIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNS 361
Query: 113 LQLGYNRLRNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLN 172
L L N++ +L G+ GL L+ L L AN I + +F + N+ + L N+IQ L
Sbjct: 362 LVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLA 421
Query: 173 SGTFAGLAKLSVCELYSNPFYCSCELLGFLRWLAAF--TNATQTYDRMQCESP 223
GTF L + L NPF C C L+WLA F TN +T +C SP
Sbjct: 422 KGTFTSLRAIQTLHLAQNPFICDCN----LKWLADFLRTNPIET-SGARCASP 469
Score = 94.4 bits (233), Expect = 4e-19
Identities = 57/155 (36%), Positives = 83/155 (53%), Gaps = 5/155 (3%)
Query: 54 IPQQINSTIVDLRLNENRIRSVQYASLSRFGNLTYL---NLTKNEIGYIEDGAFSGQFNL 110
IP++I + +LRLN N I ++ + F LT+L NL+ N++ IEDGAF G ++
Sbjct: 534 IPERIPQSTAELRLNNNEISILEATGM--FKKLTHLKKINLSNNKVSEIEDGAFEGAASV 591
Query: 111 QVLQLGYNRLRNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQ 170
L L N+L ++ GM RGL L L L+ N I + SF N+ + L N+I
Sbjct: 592 SELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITT 651
Query: 171 LNSGTFAGLAKLSVCELYSNPFYCSCELLGFLRWL 205
++ G F L LS L +NPF C+C+L WL
Sbjct: 652 VSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWL 686
Score = 69.7 bits (169), Expect = 1e-11
Identities = 49/178 (27%), Positives = 72/178 (40%), Gaps = 24/178 (13%)
Query: 52 EAIPQQINSTIVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQ 111
+AIP+ I L LN N I + + L L L +N+IG +E GAF L+
Sbjct: 53 QAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELE 112
Query: 112 VLQLGYNRLRNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQL 171
L+L N+L L E + + L L L N I+ + +F ++ N+ L N+I +
Sbjct: 113 RLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCI 172
Query: 172 NSGTFAGL------------------------AKLSVCELYSNPFYCSCELLGFLRWL 205
G F L KL L+SN +C C L +WL
Sbjct: 173 EEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWL 230
Score = 57.0 bits (136), Expect = 7e-08
Identities = 48/181 (26%), Positives = 73/181 (40%), Gaps = 30/181 (16%)
Query: 53 AIPQQINSTIVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQV 112
A+P+ I + +L L+ N+ V LS F L ++L+ N+I + + +F+ L
Sbjct: 754 ALPKGIPKNVTELYLDGNQFTLVP-GQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTT 812
Query: 113 LQLGYNRLRNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLN 172
L L YN L+ + +GL L L L N I L
Sbjct: 813 LILSYNALQCIPPLAFQGLRSLRLLSLHGN------------------------DISTLQ 848
Query: 173 SGTFAGLAKLSVCELYSNPFYCSCELLGFLRWLAAFTNATQTYDRM-QCESPPVYSGYYL 231
G FA + LS + +NP YC C LRWL+++ + +C P G L
Sbjct: 849 EGIFADVTSLSHLAIGANPLYCDCH----LRWLSSWVKTGYKEPGIARCAGPQDMEGKLL 904
Query: 232 L 232
L
Sbjct: 905 L 905
Score = 40.8 bits (94), Expect = 0.005
Identities = 29/96 (30%), Positives = 50/96 (52%), Gaps = 6/96 (6%)
Query: 51 YEAIPQQINS----TIVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSG 106
+ +P Q+++ +VDL + N+I S+ +S + LT L L+ N + I AF G
Sbjct: 773 FTLVPGQLSTFKYLQLVDL--SNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQG 830
Query: 107 QFNLQVLQLGYNRLRNLTEGMLRGLGKLEYLYLQAN 142
+L++L L N + L EG+ + L +L + AN
Sbjct: 831 LRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGAN 866
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 93.2 bits (230), Expect = 9e-19
Identities = 62/173 (35%), Positives = 81/173 (46%), Gaps = 3/173 (1%)
Query: 52 EAIPQQINST-IVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNL 110
EA+P T I+DLR N RIR +Q + R NL L L N+I I GAF NL
Sbjct: 55 EAVPAVAPQTSILDLRFN--RIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENL 112
Query: 111 QVLQLGYNRLRNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQ 170
+ L L N ++++ +GL LE LYL N IE + SF P + + L NRI
Sbjct: 113 KYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITH 172
Query: 171 LNSGTFAGLAKLSVCELYSNPFYCSCELLGFLRWLAAFTNATQTYDRMQCESP 223
L GTF L + L SN +C CE+L L + + CE P
Sbjct: 173 LVPGTFNHLESMKRLRLDSNTLHCDCEILWLADLLKTYAESGNAQAAAICEYP 225
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 93.2 bits (230), Expect = 9e-19
Identities = 53/153 (34%), Positives = 81/153 (52%), Gaps = 1/153 (0%)
Query: 54 IPQQINSTIVDLRLNENRIRSVQYASL-SRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQV 112
IP + + DLRLN+N + ++ + + NL +NL+ N+I + +GAF G ++Q
Sbjct: 526 IPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQE 585
Query: 113 LQLGYNRLRNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLN 172
L L N+L + + RGL L+ L L++NLI V +F ++ + L NRI +
Sbjct: 586 LMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTIT 645
Query: 173 SGTFAGLAKLSVCELYSNPFYCSCELLGFLRWL 205
G F L LS L SNPF C+C L +WL
Sbjct: 646 PGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWL 678
Score = 91.3 bits (225), Expect = 3e-18
Identities = 53/172 (30%), Positives = 91/172 (52%), Gaps = 7/172 (4%)
Query: 54 IPQQINSTIVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVL 113
IP + IV++RL +N I+++ + +++ L ++++KN+I I AF G +L L
Sbjct: 301 IPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSL 360
Query: 114 QLGYNRLRNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLNS 173
L N++ + +G+ GL L+ L L AN I + ++F + N+ + L N++Q ++
Sbjct: 361 VLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISK 420
Query: 174 GTFAGLAKLSVCELYSNPFYCSCELLGFLRWLAAF--TNATQTYDRMQCESP 223
G FA L + L NPF C C L+WLA + N +T +C SP
Sbjct: 421 GLFAPLQSIQTLHLAQNPFVCDCH----LKWLADYLQDNPIET-SGARCSSP 467
Score = 65.9 bits (159), Expect = 2e-10
Identities = 48/177 (27%), Positives = 71/177 (40%), Gaps = 24/177 (13%)
Query: 53 AIPQQINSTIVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQV 112
A+P+ I L L+ N I + + NL L+L N++ IE GAF L+
Sbjct: 54 AVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLER 113
Query: 113 LQLGYNRLRNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLN 172
L+L N+L+ L E + + KL L L N I+ + +F ++ N+ L N I +
Sbjct: 114 LRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIE 173
Query: 173 SGTFAGL------------------------AKLSVCELYSNPFYCSCELLGFLRWL 205
G F L K+ L+SN YC C L WL
Sbjct: 174 DGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWL 230
Score = 59.3 bits (142), Expect = 1e-08
Identities = 50/181 (27%), Positives = 74/181 (40%), Gaps = 30/181 (16%)
Query: 53 AIPQQINSTIVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQV 112
A+P+ + + +L L N + +V LS +LT ++L+ N I + + FS +L
Sbjct: 745 ALPRGMPKDVTELYLEGNHLTAVP-RELSALRHLTLIDLSNNSISMLTNYTFSNMSHLST 803
Query: 113 LQLGYNRLRNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLN 172
L L YNRLR + GL L L L N I +
Sbjct: 804 LILSYNRLRCIPVHAFNGLRSLRVLTLHG------------------------NDISSVP 839
Query: 173 SGTFAGLAKLSVCELYSNPFYCSCELLGFLRWLAAFTNATQTYDRM-QCESPPVYSGYYL 231
G+F L LS L +NP +C C LRWL+ + A + +C SP + L
Sbjct: 840 EGSFNDLTSLSHLALGTNPLHCDCS----LRWLSEWVKAGYKEPGIARCSSPEPMADRLL 895
Query: 232 L 232
L
Sbjct: 896 L 896
>gi|40217820 slit and trk like 3 protein [Homo sapiens]
Length = 977
Score = 92.8 bits (229), Expect = 1e-18
Identities = 71/249 (28%), Positives = 118/249 (47%), Gaps = 45/249 (18%)
Query: 52 EAIPQQINSTIVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQ 111
E +P+ +N+ L L+ N I+ + + F +L L+L N I Y++DGAF NL+
Sbjct: 402 ELLPRPLNAK--KLYLSSNLIQKIYRSDFWNFSSLDLLHLGNNRISYVQDGAFINLPNLK 459
Query: 112 VLQLGYNRLRNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQL 171
L L N + LT GM RGL L YLY + N+I + ++F PN+ + L+ N ++ L
Sbjct: 460 SLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVIREIQPAAFSLMPNLKLLFLNNNLLRTL 519
Query: 172 NSGTFAG--LAKLSV----------------------CELYSNPFYCSCELLGFLRWLAA 207
+ FAG LA+L++ +L NP+ C+C+L+ F +W+
Sbjct: 520 PTDAFAGTSLARLNLRKNYFLYLPVAGVLEHLNAIVQIDLNENPWDCTCDLVPFKQWIET 579
Query: 208 FTNATQTYDRMQCESPPVYSGYYLLGQGRRGHRSILS-KLQSVCTEDSYAAEVVGPPRPA 266
++ + D + C SP + HR + + +L+ +C E + A P
Sbjct: 580 ISSVSVVGD-VLCRSPENLT-----------HRDVRTIELEVLCPEMLHVAPAGESP--- 624
Query: 267 SGRSQPGRS 275
+QPG S
Sbjct: 625 ---AQPGDS 630
Score = 68.6 bits (166), Expect = 2e-11
Identities = 61/264 (23%), Positives = 108/264 (40%), Gaps = 20/264 (7%)
Query: 63 VDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRLRN 122
V + L N ++ +Q + + L L L +N++ + F G +L+ LQ YN ++
Sbjct: 104 VSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFRNDTFLGLESLEYLQADYNVIKR 163
Query: 123 LTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQL-NSGTFAGLAK 181
+ G R L KL L L NLI ++ ++ ++ ++ ++DL NR++ L G + +
Sbjct: 164 IESGAFRNLSKLRVLILNDNLIP-MLPTNLFKAVSLTHLDLRGNRLKVLFYRGMLDHIGR 222
Query: 182 -LSVCELYSNPFYCSCELLGFLRWLAAFTNATQTYDRMQCESPPVYSGYYLLGQGRRGHR 240
L +L NP+ C+CE++ WL D + CE+P + G L +
Sbjct: 223 SLMELQLEENPWNCTCEIVQLKSWLERIPYTALVGD-ITCETPFHFHGKDLREIRKTELC 281
Query: 241 SILSKLQSVCT----EDSYAAEVVGPPRPASGRS------------QPGRSPPPPPPPEP 284
+LS + + S + E P +P+S S + P P P
Sbjct: 282 PLLSDSEVEASLGIPHSSSSKENAWPTKPSSMLSSVHFTASSVEYKSSNKQPKPTKQPRT 341
Query: 285 SDMPCADDECFSGDGTTPLVALPT 308
P + G P+ T
Sbjct: 342 PRPPSTSQALYPGPNQPPIAPYQT 365
Score = 47.4 bits (111), Expect = 6e-05
Identities = 30/102 (29%), Positives = 49/102 (48%)
Query: 89 LNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRLRNLTEGMLRGLGKLEYLYLQANLIEVVM 148
L L +N + + +F N + LG N L+++ G GL L+ LYL N ++V
Sbjct: 82 LYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFR 141
Query: 149 ASSFWECPNIVNIDLSMNRIQQLNSGTFAGLAKLSVCELYSN 190
+F ++ + N I+++ SG F L+KL V L N
Sbjct: 142 NDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDN 183
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 89.4 bits (220), Expect = 1e-17
Identities = 54/172 (31%), Positives = 87/172 (50%), Gaps = 7/172 (4%)
Query: 54 IPQQINSTIVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVL 113
IP + TI ++RL +N I+ + + S + L ++L+ N+I + AF G +L L
Sbjct: 294 IPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSL 353
Query: 114 QLGYNRLRNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLNS 173
L N++ L + + GL L+ L L AN I + +F + N+ + L N++Q +
Sbjct: 354 VLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAK 413
Query: 174 GTFAGLAKLSVCELYSNPFYCSCELLGFLRWLAAF--TNATQTYDRMQCESP 223
GTF+ L + L NPF C C L+WLA + TN +T +C SP
Sbjct: 414 GTFSPLRAIQTMHLAQNPFICDCH----LKWLADYLHTNPIET-SGARCTSP 460
Score = 81.3 bits (199), Expect = 3e-15
Identities = 51/153 (33%), Positives = 75/153 (49%), Gaps = 1/153 (0%)
Query: 54 IPQQINSTIVDLRLNENRIRSVQYASL-SRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQV 112
IP+ I +LRLN N ++ + + L +N + N+I IE+GAF G +
Sbjct: 527 IPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNE 586
Query: 113 LQLGYNRLRNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLN 172
+ L NRL N+ M +GL L+ L L++N I V SF ++ + L N+I +
Sbjct: 587 ILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVA 646
Query: 173 SGTFAGLAKLSVCELYSNPFYCSCELLGFLRWL 205
G F L LS L +NPF C+C L WL
Sbjct: 647 PGAFDTLHSLSTLNLLANPFNCNCYLAWLGEWL 679
Score = 67.8 bits (164), Expect = 4e-11
Identities = 60/226 (26%), Positives = 87/226 (38%), Gaps = 32/226 (14%)
Query: 53 AIPQQINSTIVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQV 112
++P+ I L LN N I + + +L L L +N+I IE GAF L+
Sbjct: 48 SVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELER 107
Query: 113 LQLGYNRLRNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLN 172
L+L N L+ E + G KL L L N I+ + +F +I N+ L N+I +
Sbjct: 108 LRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIE 167
Query: 173 SGTFAGL------------------------AKLSVCELYSNPFYCSCELLGFLRWLAAF 208
G F L KL L+SN YC C L WL
Sbjct: 168 DGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWL--- 224
Query: 209 TNATQTYDRMQCESPPVYSGYYLLGQGRR-----GHRSILSKLQSV 249
+ QC P G+ + +R GH+S ++ SV
Sbjct: 225 RQRPRVGLYTQCMGPSHLRGHNVAEVQKREFVCSGHQSFMAPSCSV 270
Score = 57.4 bits (137), Expect = 5e-08
Identities = 43/154 (27%), Positives = 64/154 (41%), Gaps = 25/154 (16%)
Query: 52 EAIPQQINSTIVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQ 111
+ +P+ I + +L L+ N+ V LS + +LT ++L+ N I + + +FS L
Sbjct: 746 KVLPKGIPRDVTELYLDGNQFTLVP-KELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLL 804
Query: 112 VLQLGYNRLRNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQL 171
L L YNRLR + GL L L L N I VV
Sbjct: 805 TLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVV------------------------ 840
Query: 172 NSGTFAGLAKLSVCELYSNPFYCSCELLGFLRWL 205
G F L+ LS + +NP YC C + W+
Sbjct: 841 PEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWV 874
>gi|194306623 immunoglobulin superfamily containing leucine-rich
repeat 2 [Homo sapiens]
Length = 745
Score = 89.4 bits (220), Expect = 1e-17
Identities = 61/221 (27%), Positives = 104/221 (47%), Gaps = 7/221 (3%)
Query: 8 ALWVCVAAATLLHAGGLARADCWLIEGDKGFVWLAICSQNQPPYEAIPQQINSTIVDLRL 67
ALW+ A LL G C + DK A C+ + +P+ + + + L L
Sbjct: 6 ALWLVWA---LLGVAGSCPEPCACV--DKYAHQFADCAYKE--LREVPEGLPANVTTLSL 58
Query: 68 NENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRLRNLTEGM 127
+ N+I ++ + + +T L L NE+ +E GA + L+ L L +N + +
Sbjct: 59 SANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSD 118
Query: 128 LRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLNSGTFAGLAKLSVCEL 187
LR L L+ L + N + + + P++ ++ ++ NR++ L GTF L+ LS +L
Sbjct: 119 LRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQL 178
Query: 188 YSNPFYCSCELLGFLRWLAAFTNATQTYDRMQCESPPVYSG 228
Y NPF+C C L+ W A+ + D + C SPP G
Sbjct: 179 YHNPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQG 219
>gi|194306621 immunoglobulin superfamily containing leucine-rich
repeat 2 [Homo sapiens]
Length = 745
Score = 89.4 bits (220), Expect = 1e-17
Identities = 61/221 (27%), Positives = 104/221 (47%), Gaps = 7/221 (3%)
Query: 8 ALWVCVAAATLLHAGGLARADCWLIEGDKGFVWLAICSQNQPPYEAIPQQINSTIVDLRL 67
ALW+ A LL G C + DK A C+ + +P+ + + + L L
Sbjct: 6 ALWLVWA---LLGVAGSCPEPCACV--DKYAHQFADCAYKE--LREVPEGLPANVTTLSL 58
Query: 68 NENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRLRNLTEGM 127
+ N+I ++ + + +T L L NE+ +E GA + L+ L L +N + +
Sbjct: 59 SANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSD 118
Query: 128 LRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLNSGTFAGLAKLSVCEL 187
LR L L+ L + N + + + P++ ++ ++ NR++ L GTF L+ LS +L
Sbjct: 119 LRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQL 178
Query: 188 YSNPFYCSCELLGFLRWLAAFTNATQTYDRMQCESPPVYSG 228
Y NPF+C C L+ W A+ + D + C SPP G
Sbjct: 179 YHNPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQG 219
>gi|39930401 immunoglobulin superfamily containing leucine-rich
repeat 2 [Homo sapiens]
Length = 745
Score = 89.4 bits (220), Expect = 1e-17
Identities = 61/221 (27%), Positives = 104/221 (47%), Gaps = 7/221 (3%)
Query: 8 ALWVCVAAATLLHAGGLARADCWLIEGDKGFVWLAICSQNQPPYEAIPQQINSTIVDLRL 67
ALW+ A LL G C + DK A C+ + +P+ + + + L L
Sbjct: 6 ALWLVWA---LLGVAGSCPEPCACV--DKYAHQFADCAYKE--LREVPEGLPANVTTLSL 58
Query: 68 NENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRLRNLTEGM 127
+ N+I ++ + + +T L L NE+ +E GA + L+ L L +N + +
Sbjct: 59 SANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSD 118
Query: 128 LRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLNSGTFAGLAKLSVCEL 187
LR L L+ L + N + + + P++ ++ ++ NR++ L GTF L+ LS +L
Sbjct: 119 LRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQL 178
Query: 188 YSNPFYCSCELLGFLRWLAAFTNATQTYDRMQCESPPVYSG 228
Y NPF+C C L+ W A+ + D + C SPP G
Sbjct: 179 YHNPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQG 219
>gi|194306618 immunoglobulin superfamily containing leucine-rich
repeat 2 [Homo sapiens]
Length = 745
Score = 89.4 bits (220), Expect = 1e-17
Identities = 61/221 (27%), Positives = 104/221 (47%), Gaps = 7/221 (3%)
Query: 8 ALWVCVAAATLLHAGGLARADCWLIEGDKGFVWLAICSQNQPPYEAIPQQINSTIVDLRL 67
ALW+ A LL G C + DK A C+ + +P+ + + + L L
Sbjct: 6 ALWLVWA---LLGVAGSCPEPCACV--DKYAHQFADCAYKE--LREVPEGLPANVTTLSL 58
Query: 68 NENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRLRNLTEGM 127
+ N+I ++ + + +T L L NE+ +E GA + L+ L L +N + +
Sbjct: 59 SANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSD 118
Query: 128 LRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLNSGTFAGLAKLSVCEL 187
LR L L+ L + N + + + P++ ++ ++ NR++ L GTF L+ LS +L
Sbjct: 119 LRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQL 178
Query: 188 YSNPFYCSCELLGFLRWLAAFTNATQTYDRMQCESPPVYSG 228
Y NPF+C C L+ W A+ + D + C SPP G
Sbjct: 179 YHNPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQG 219
>gi|126517478 peroxidasin homolog-like [Homo sapiens]
Length = 1463
Score = 85.9 bits (211), Expect = 1e-16
Identities = 54/170 (31%), Positives = 83/170 (48%), Gaps = 4/170 (2%)
Query: 54 IPQQINSTIVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVL 113
+PQQ +T++DLR N RIR + ++ + NL L L N I I AF G NL L
Sbjct: 48 VPQQ--TTVLDLRFN--RIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYL 103
Query: 114 QLGYNRLRNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLNS 173
L N + L + +GL LE+LY+ N +E++ +F + + + L N++ ++ +
Sbjct: 104 YLYKNEIHALDKQTFKGLISLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPA 163
Query: 174 GTFAGLAKLSVCELYSNPFYCSCELLGFLRWLAAFTNATQTYDRMQCESP 223
G+F+ L L L SN C C+L+ L F T CE P
Sbjct: 164 GSFSNLDSLKRLRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAATCEYP 213
>gi|40217823 SLIT and NTRK-like family, member 5 [Homo sapiens]
Length = 958
Score = 85.1 bits (209), Expect = 2e-16
Identities = 65/225 (28%), Positives = 102/225 (45%), Gaps = 37/225 (16%)
Query: 67 LNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRLRNLTEG 126
L EN I V+ L L+L N I I+D AF NL+ L L NR+ L+
Sbjct: 416 LTENYIAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPE 475
Query: 127 MLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLNSGTFAGLAKLSV-- 184
+ GL L+YL+LQ NLI + + +F PN+ + L+ N +Q + SG F+GL L +
Sbjct: 476 LFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSGLTLLRLNL 535
Query: 185 ----------------------CELYSNPFYCSCELLGFLRWLAAFTNATQTYDRMQCES 222
+L+ NP+ C+C+++G W+ D + C++
Sbjct: 536 RSNHFTSLPVSGVLDQLKSLIQIDLHDNPWDCTCDIVGMKLWVEQL-KVGVLVDEVICKA 594
Query: 223 PPVYSGYYLLGQGRRGHRSILSKLQSVCTEDSYAAEVVGPPRPAS 267
P ++ RSI S+L +C + Y+ VV P P+S
Sbjct: 595 PKKFA--------ETDMRSIKSEL--LCPD--YSDVVVSTPTPSS 627
Score = 63.5 bits (153), Expect = 7e-10
Identities = 53/186 (28%), Positives = 82/186 (44%), Gaps = 25/186 (13%)
Query: 62 IVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRLR 121
I L L+ N + + + + L+L N I IE GAF G L+ L L N+L
Sbjct: 83 IYHLLLSGNLLNRLYPNEFVNYTGASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLE 142
Query: 122 NLTEGMLRGLGKLEYLYLQANLIEVVMASSFWE----------------CPN-------I 158
L + GL LEYL + N I V+ ++F + PN +
Sbjct: 143 LLRDDTFLGLENLEYLQVDYNYISVIEPNAFGKLHLLQVLILNDNLLSSLPNNLFRFVPL 202
Query: 159 VNIDLSMNRIQQL-NSGTFAGLAKLSVCELYSNPFYCSCELLGFLRWLAAFTNATQTYDR 217
++DL NR++ L G + K+ +L NP+ CSCEL+ WL + + + D
Sbjct: 203 THLDLRGNRLKLLPYVGLLQHMDKVVELQLEENPWNCSCELISLKDWLDSISYSALVGD- 261
Query: 218 MQCESP 223
+ CE+P
Sbjct: 262 VVCETP 267
Score = 33.1 bits (74), Expect = 1.1
Identities = 27/89 (30%), Positives = 37/89 (41%), Gaps = 11/89 (12%)
Query: 109 NLQVLQLGYNRLRNLTEGMLRGLGKLE-------YLYLQANLIEVVMASSFWECPNIVNI 161
NLQ+ LG N N E + + +L+ +YL N I VV + F E + +
Sbjct: 381 NLQISDLGLNV--NCQERKIESIAELQPKPYNPKKMYLTENYIAVVRRTDFLEATGLDLL 438
Query: 162 DLSMNRIQQLNSGTFAGLAKLSVCELYSN 190
L NRI + F L L LY N
Sbjct: 439 HLGNNRISMIQDRAFGDLTNLR--RLYLN 465
>gi|40217825 slit and trk like 6 [Homo sapiens]
Length = 841
Score = 83.2 bits (204), Expect = 9e-16
Identities = 58/183 (31%), Positives = 86/183 (46%), Gaps = 25/183 (13%)
Query: 65 LRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRLRNLT 124
L L N I S+ + L + L L+L N I +E+G+F LQ L L N L L+
Sbjct: 368 LILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLS 427
Query: 125 EGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLNSGTFAG------ 178
+GM GL LEYLYL+ N I+ ++ +F P + + L+ N +Q L F+G
Sbjct: 428 KGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKV 487
Query: 179 ------------------LAKLSVCELYSNPFYCSCELLGFLRWLAAFTNATQTYDRMQC 220
L L+ +L NP+ CSC+L+G +W+ + T T D + C
Sbjct: 488 NLKTNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVT-DDILC 546
Query: 221 ESP 223
SP
Sbjct: 547 TSP 549
Score = 64.3 bits (155), Expect = 4e-10
Identities = 50/191 (26%), Positives = 87/191 (45%), Gaps = 17/191 (8%)
Query: 63 VDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRLRN 122
+ + L N I ++ + + G L L++ N + +++ F G NL+ LQ N +
Sbjct: 91 ISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNFITV 150
Query: 123 LTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQL-NSGTFAGLAK 181
+ L +L+ L L N IE + + F P + ++DL N++Q L G + +
Sbjct: 151 IEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVP-LTHLDLRGNQLQTLPYVGFLEHIGR 209
Query: 182 LSVCELYSNPFYCSCELLGFLRWLAAFTNATQTYDRMQCESPPVYSGYYLLGQGRRGHRS 241
+ +L N + C+C+LL WL + D + C SPP + G S
Sbjct: 210 ILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGD-VVCNSPPFFKG------------S 256
Query: 242 ILSKL--QSVC 250
ILS+L +S+C
Sbjct: 257 ILSRLKKESIC 267
Score = 35.0 bits (79), Expect = 0.29
Identities = 26/82 (31%), Positives = 38/82 (46%)
Query: 109 NLQVLQLGYNRLRNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRI 168
N + L L N + +L + L LE L+L N IEV+ SF + + L+ N +
Sbjct: 364 NPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHL 423
Query: 169 QQLNSGTFAGLAKLSVCELYSN 190
+L+ G F GL L L N
Sbjct: 424 TKLSKGMFLGLHNLEYLYLEYN 445
>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
Length = 560
Score = 82.4 bits (202), Expect = 2e-15
Identities = 50/166 (30%), Positives = 81/166 (48%), Gaps = 1/166 (0%)
Query: 64 DLRLNENRIRSVQYASLSRFGNLTYLNLTKN-EIGYIEDGAFSGQFNLQVLQLGYNRLRN 122
+L LN ++R++ A+ L YL +T + + + GAF G LQVL L N L
Sbjct: 294 ELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTA 353
Query: 123 LTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLNSGTFAGLAKL 182
L +G+LRGLGKL + L+ N + + + F ++ ++ L N+++ L F L +L
Sbjct: 354 LPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRL 413
Query: 183 SVCELYSNPFYCSCELLGFLRWLAAFTNATQTYDRMQCESPPVYSG 228
+ L N + C C L FL WL + +C P ++G
Sbjct: 414 TEVLLGHNSWRCDCGLGPFLGWLRQHLGLVGGEEPPRCAGPGAHAG 459
Score = 65.5 bits (158), Expect = 2e-10
Identities = 43/139 (30%), Positives = 67/139 (48%), Gaps = 3/139 (2%)
Query: 64 DLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRLRNL 123
+L LN+N++ + + + NL L+L+ N + ++ G Q L+ L L NRL +L
Sbjct: 150 ELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSL 209
Query: 124 TEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLNSGTFAGLAKLS 183
G+L LG L L N I + +F PN+ ++ LS N + L S F L+
Sbjct: 210 DSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLT 269
Query: 184 VCELYSNPFYCSCELLGFL 202
+ L+ NP EL G L
Sbjct: 270 LLTLFENPL---AELPGVL 285
Score = 61.2 bits (147), Expect = 4e-09
Identities = 36/130 (27%), Positives = 66/130 (50%), Gaps = 1/130 (0%)
Query: 62 IVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRLR 121
+ +L+ + N IRS+ + R NL+ L L++N + ++ F NL +L L N L
Sbjct: 220 LTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLA 279
Query: 122 NLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMN-RIQQLNSGTFAGLA 180
L + +G L+ L+L + + A++F + + ++++ R+ L G F GL
Sbjct: 280 ELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLG 339
Query: 181 KLSVCELYSN 190
+L V L+SN
Sbjct: 340 ELQVLALHSN 349
Score = 55.8 bits (133), Expect = 2e-07
Identities = 37/126 (29%), Positives = 61/126 (48%)
Query: 65 LRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRLRNLT 124
L ++++ I +V + S L L L++N+I ++ L+ L L +N LR +
Sbjct: 79 LMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGID 138
Query: 125 EGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLNSGTFAGLAKLSV 184
+ M + L L+ L L N ++ + AS F N+ +DLS N + L G AKL
Sbjct: 139 QNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLER 198
Query: 185 CELYSN 190
L+SN
Sbjct: 199 LLLHSN 204
Score = 47.8 bits (112), Expect = 4e-05
Identities = 30/116 (25%), Positives = 55/116 (47%)
Query: 75 VQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRLRNLTEGMLRGLGKL 134
+Q S S L L ++ + I + G FS L+ L+L N++ +L +L + L
Sbjct: 65 LQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLL 124
Query: 135 EYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLNSGTFAGLAKLSVCELYSN 190
E L+L N + + + F + N+ + L+ N++ L + F L L + +L N
Sbjct: 125 EQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGN 180
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 81.3 bits (199), Expect = 3e-15
Identities = 46/152 (30%), Positives = 81/152 (53%), Gaps = 2/152 (1%)
Query: 41 LAICSQNQPPYEAIPQQINST--IVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGY 98
L + N+ AIP ++ + L LN N+I++V + G L L + +N +
Sbjct: 194 LLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTK 253
Query: 99 IEDGAFSGQFNLQVLQLGYNRLRNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNI 158
+ DGAF G N+++LQL +N L +T+G L GL L+ L+L N I + ++ C +
Sbjct: 254 LMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKL 313
Query: 159 VNIDLSMNRIQQLNSGTFAGLAKLSVCELYSN 190
+DL+ N + +L+ +F GL+ L+ + +N
Sbjct: 314 SELDLTFNHLSRLDDSSFLGLSLLNTLHIGNN 345
Score = 71.6 bits (174), Expect = 3e-12
Identities = 49/168 (29%), Positives = 74/168 (44%), Gaps = 5/168 (2%)
Query: 64 DLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRLRNL 123
+L L N + + +S L L++ N + YI D AF G +L+ L L N +
Sbjct: 315 ELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWT 374
Query: 124 TE---GMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLNSGTFAGLA 180
E G GL KL L LQ N I + +F + ++DLS N I L F+ +
Sbjct: 375 IEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMK 434
Query: 181 KLSVCELYSNPFYCSCELLGFLRWLAAFTNATQTYDRMQCESPPVYSG 228
KL L ++ C C+L +W+A N Q++ C P + G
Sbjct: 435 KLQQLHLNTSSLLCDCQLKWLPQWVA--ENNFQSFVNASCAHPQLLKG 480
Score = 43.5 bits (101), Expect = 8e-04
Identities = 38/139 (27%), Positives = 67/139 (48%), Gaps = 6/139 (4%)
Query: 54 IPQQINSTIVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIED-GAFSGQFNLQV 112
+P+ + S + L L+ NR+ ++ +S+S +L + L NE+ I + G S N+ +
Sbjct: 68 LPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSA--NITL 125
Query: 113 LQLGYNRLRNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLN 172
L L NR+ + L+ LE L L +N I + + + + + L+ NR+ +
Sbjct: 126 LSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTA--FPALQLKYLYLNSNRVTSME 183
Query: 173 SGTFAGLAK-LSVCELYSN 190
G F LA L V +L N
Sbjct: 184 PGYFDNLANTLLVLKLNRN 202
>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
isoform 1 [Homo sapiens]
Length = 1059
Score = 81.3 bits (199), Expect = 3e-15
Identities = 46/152 (30%), Positives = 81/152 (53%), Gaps = 2/152 (1%)
Query: 41 LAICSQNQPPYEAIPQQINST--IVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGY 98
L + N+ AIP ++ + L LN N+I++V + G L L + +N +
Sbjct: 134 LLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTK 193
Query: 99 IEDGAFSGQFNLQVLQLGYNRLRNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNI 158
+ DGAF G N+++LQL +N L +T+G L GL L+ L+L N I + ++ C +
Sbjct: 194 LMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKL 253
Query: 159 VNIDLSMNRIQQLNSGTFAGLAKLSVCELYSN 190
+DL+ N + +L+ +F GL+ L+ + +N
Sbjct: 254 SELDLTFNHLSRLDDSSFLGLSLLNTLHIGNN 285
Score = 71.6 bits (174), Expect = 3e-12
Identities = 49/168 (29%), Positives = 74/168 (44%), Gaps = 5/168 (2%)
Query: 64 DLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRLRNL 123
+L L N + + +S L L++ N + YI D AF G +L+ L L N +
Sbjct: 255 ELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWT 314
Query: 124 TE---GMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLNSGTFAGLA 180
E G GL KL L LQ N I + +F + ++DLS N I L F+ +
Sbjct: 315 IEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMK 374
Query: 181 KLSVCELYSNPFYCSCELLGFLRWLAAFTNATQTYDRMQCESPPVYSG 228
KL L ++ C C+L +W+A N Q++ C P + G
Sbjct: 375 KLQQLHLNTSSLLCDCQLKWLPQWVA--ENNFQSFVNASCAHPQLLKG 420
Score = 37.7 bits (86), Expect = 0.044
Identities = 35/126 (27%), Positives = 60/126 (47%), Gaps = 6/126 (4%)
Query: 67 LNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIED-GAFSGQFNLQVLQLGYNRLRNLTE 125
L+ NR+ ++ +S+S +L + L NE+ I + G S N+ +L L NR+ +
Sbjct: 21 LSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSA--NITLLSLAGNRIVEILP 78
Query: 126 GMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLNSGTFAGLAK-LSV 184
L+ LE L L +N I + + + + + L+ NR+ + G F LA L V
Sbjct: 79 EHLKEFQSLETLDLSSNNISELQTA--FPALQLKYLYLNSNRVTSMEPGYFDNLANTLLV 136
Query: 185 CELYSN 190
+L N
Sbjct: 137 LKLNRN 142
>gi|13375646 leucine rich repeat and fibronectin type III domain
containing 3 [Homo sapiens]
Length = 628
Score = 80.9 bits (198), Expect = 5e-15
Identities = 116/508 (22%), Positives = 181/508 (35%), Gaps = 136/508 (26%)
Query: 54 IPQQINSTIVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVL 113
+P ++ +LRL +N I SV+ L+ L +L+L++N I ++ GAF+ L+ L
Sbjct: 53 VPPSLDRRAAELRLADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRAL 112
Query: 114 QLGYNRLRNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWEC-PNIVNIDLSMNRIQQL- 171
L NRL +L EG LRGL L +L L N + + A + +C + ++DLS N ++QL
Sbjct: 113 HLDGNRLTSLGEGQLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLP 172
Query: 172 -----------------------NSGTFAGLAKLSVCELYS------------------- 189
+G F+ L KL+ ++ S
Sbjct: 173 WEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPLFSRLPLLA 232
Query: 190 ----------------NPFYCSCELLGFLRWLAAFTNATQTYDRMQCESPPVYSGYY--- 230
NP +C+CEL+ +LR LA + D C SPP G Y
Sbjct: 233 RPRGSPASALVLAFGGNPLHCNCELV-WLRRLA------REDDLEACASPPALGGRYFWA 285
Query: 231 --------------------------------------------------LLGQGRRGHR 240
LLG R
Sbjct: 286 VGEEEFVCEPPVVTHRSPPLAVPAGRPAALRCRAVGDPEPRVRWVSPQGRLLGNSSRARA 345
Query: 241 SILSKLQSVCTEDSYAAEVVGPPRPASGRSQPGRSPPPPPPPEP---SDMPCADDECFSG 297
L+ + TE A+G + PPP P + C
Sbjct: 346 FPNGTLELLVTEPGDGGIFTCIAANAAGEATAAVELTVGPPPPPQLANSTSCDPPRDGDP 405
Query: 298 DGTTPLVALPTLATQAE-ARPLIKVKQLTQNSATITV-----QLPSPFHRMYTLEHFNNS 351
D TP A A A+ P + Q+T++ AT + Q P P RMY +++ +++
Sbjct: 406 DALTPPSAASASAKVADTGPPTDRGVQVTEHGATAALVQWPDQRPIPGIRMYQIQYNSSA 465
Query: 352 KASTVSRLTKAQ-EEIRLTNLFTLTNYTYCVVS----TSAGLRHNHT--CLTICLPRLPS 404
V R+ A+ LT+L + Y CV++ ++ GL C
Sbjct: 466 DDILVYRMIPAESRSFLLTDLASGRTYDLCVLAVYEDSATGLTATRPVGCARFSTEPALR 525
Query: 405 PPGPVPSPSTATHYIMTILGCLFGMVLV 432
P G +P I+ + G + VLV
Sbjct: 526 PCGAPHAPFLGGTMIIALGGVIVASVLV 553
>gi|27436867 slit and trk like 4 protein [Homo sapiens]
Length = 837
Score = 80.1 bits (196), Expect = 8e-15
Identities = 67/256 (26%), Positives = 111/256 (43%), Gaps = 35/256 (13%)
Query: 52 EAIPQQINSTIVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQ 111
E IP+ +N+ L +N N I+ V + + F L L+L N+I I+ F NL+
Sbjct: 371 ELIPKPLNAK--KLHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQITVIKGDVFHNLTNLR 428
Query: 112 VLQLGYNRLRNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQL 171
L L N++ L + GL L+YLYL+ NLI+ + A +F PN+ + L+ N ++ L
Sbjct: 429 RLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEISAGTFDSMPNLQLLYLNNNLLKSL 488
Query: 172 NSGTFAG------------------------LAKLSVCELYSNPFYCSCELLGFLRWLAA 207
F+G L L+ +L NP+ C+C+L+ W+
Sbjct: 489 PVYIFSGAPLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWVEK 548
Query: 208 FTNATQTYDRMQCESPPVYSGYYLLG-QGRRGHRSILSKLQSVCTEDSYAAEVVGPPRPA 266
++ ++CE+P ++ L + +L+K + T + A P P
Sbjct: 549 LSDGI-VVKELKCETPVQFANIELKSLKNEILCPKLLNKPSAPFTSPAPAITFTTPLGPI 607
Query: 267 SGRSQPGRSPPPPPPP 282
RSPP P P
Sbjct: 608 -------RSPPGGPVP 616
Score = 73.2 bits (178), Expect = 9e-13
Identities = 44/147 (29%), Positives = 74/147 (50%), Gaps = 2/147 (1%)
Query: 60 STIVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNR 119
S V L L N++++++ + L L+L NE+ + F G NL+ LQ YN
Sbjct: 83 SHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNL 142
Query: 120 LRNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQL-NSGTFAG 178
++ + G L KL+ L L NLI + + + ++ ++D+ NRIQ+L G
Sbjct: 143 IKYIERGAFNKLHKLKVLILNDNLIS-FLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEH 201
Query: 179 LAKLSVCELYSNPFYCSCELLGFLRWL 205
+ ++ +L NP+ CSC+LL WL
Sbjct: 202 IGRVVELQLEDNPWNCSCDLLPLKAWL 228
Score = 51.6 bits (122), Expect = 3e-06
Identities = 31/108 (28%), Positives = 50/108 (46%)
Query: 83 FGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRLRNLTEGMLRGLGKLEYLYLQAN 142
+ N +LN N + + F + L LG N+L+N+ G GL L+ L+L N
Sbjct: 58 WSNFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNN 117
Query: 143 LIEVVMASSFWECPNIVNIDLSMNRIQQLNSGTFAGLAKLSVCELYSN 190
++++ A +F N+ + N I+ + G F L KL V L N
Sbjct: 118 ELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDN 165
>gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo
sapiens]
Length = 516
Score = 79.7 bits (195), Expect = 1e-14
Identities = 50/156 (32%), Positives = 81/156 (51%)
Query: 35 DKGFVWLAICSQNQPPYEAIPQQINSTIVDLRLNENRIRSVQYASLSRFGNLTYLNLTKN 94
DKG + L++ + E S + L L+ N+I +V+ + L L L+ N
Sbjct: 60 DKGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSN 119
Query: 95 EIGYIEDGAFSGQFNLQVLQLGYNRLRNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWE 154
+I Y+ + F+ NLQ L L +N+L +L + GL KL+ L+L++N + + FW+
Sbjct: 120 KIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWD 179
Query: 155 CPNIVNIDLSMNRIQQLNSGTFAGLAKLSVCELYSN 190
C ++ +DLS NR++ L FAGL KL L N
Sbjct: 180 CRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHN 215
Score = 63.2 bits (152), Expect = 1e-09
Identities = 48/168 (28%), Positives = 75/168 (44%), Gaps = 2/168 (1%)
Query: 65 LRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRLRNLT 124
L L+ NR+RS+ + L L+L N++ I F +L L L +N++ NLT
Sbjct: 186 LDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLT 245
Query: 125 EGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLNSGTFAGLAKLSV 184
GM G LE L L N I+ + + F PN+ + + N++ L+S L L+
Sbjct: 246 CGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTT 305
Query: 185 CELYSNPFYCSCELLGFLRWLAAFTNATQTYDRMQCESPPVYSGYYLL 232
L N + CS + WL +F + + C SP G +L
Sbjct: 306 VGLSGNLWECSARICALASWLGSFQGRWE--HSILCHSPDHTQGEDIL 351
Score = 40.0 bits (92), Expect = 0.009
Identities = 30/96 (31%), Positives = 45/96 (46%), Gaps = 9/96 (9%)
Query: 60 STIVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNR 119
S++ L L N+I ++ +G L L+LT NEI I+ F NL++L + N+
Sbjct: 229 SSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNK 288
Query: 120 LRNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWEC 155
L +L +L L L + L NL WEC
Sbjct: 289 LNSLDSKILNSLRSLTTVGLSGNL---------WEC 315
>gi|84781739 leucine-rich repeats and transmembrane domains 2 [Homo
sapiens]
Length = 370
Score = 79.3 bits (194), Expect = 1e-14
Identities = 60/237 (25%), Positives = 104/237 (43%), Gaps = 13/237 (5%)
Query: 54 IPQQINSTIVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVL 113
+P + + L L N++ ++ + + +L L+L+ N + + F NL L
Sbjct: 62 VPPDVPAATRTLLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTEL 121
Query: 114 QLGYNRLRNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLNS 173
QL N +R L +LR L +L L N + + F + ++ L NR+Q L+
Sbjct: 122 QLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDR 181
Query: 174 GTFAGLAKLSVCELYSNPFYCSCELLGFLRWLAAFTNATQTYDRMQCESPPVYSGYYLLG 233
TF LA L + ++ NP+ C C L F W+ F+ D++ C P G
Sbjct: 182 LTFEPLANLQLLQVGDNPWECDCNLREFKHWMEWFSYRGGRLDQLACTLPKELRG----- 236
Query: 234 QGRRGHRSILSKLQSVCT--EDSYAAEVVGPPRPASGRSQPGRSPPPP---PPPEPS 285
+ R + ++ + C+ ED ++ + P P ++ P + P P P PEPS
Sbjct: 237 ---KDMRMVPMEMFNYCSQLEDENSSAGLDIPGPPCTKASPEPAKPKPGAEPEPEPS 290
>gi|41582239 immunoglobulin superfamily containing leucine-rich
repeat [Homo sapiens]
Length = 428
Score = 78.2 bits (191), Expect = 3e-14
Identities = 56/211 (26%), Positives = 93/211 (44%), Gaps = 11/211 (5%)
Query: 23 GLARA-----DCWLIEGDKGFVWLAICSQNQPPYEAIPQQINSTIVDLRLNENRIRSVQY 77
GLA+A DC G+K +A C+ E++P + + L L+ NR+ +
Sbjct: 14 GLAQACPEPCDC----GEKYGFQIADCAYRD--LESVPPGFPANVTTLSLSANRLPGLPE 67
Query: 78 ASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRLRNLTEGMLRGLGKLEYL 137
+ L L L NEI + GA + +L+ L L +N + + L L L+ L
Sbjct: 68 GAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLL 127
Query: 138 YLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLNSGTFAGLAKLSVCELYSNPFYCSCE 197
+ +N + + +F + ++ L+ NR+ L GTF L LS ++ NPF C+C
Sbjct: 128 KMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCG 187
Query: 198 LLGFLRWLAAFTNATQTYDRMQCESPPVYSG 228
++ W + D + C SP V G
Sbjct: 188 IVWLKTWALTTAVSIPEQDNIACTSPHVLKG 218
>gi|5031809 immunoglobulin superfamily containing leucine-rich
repeat [Homo sapiens]
Length = 428
Score = 78.2 bits (191), Expect = 3e-14
Identities = 56/211 (26%), Positives = 93/211 (44%), Gaps = 11/211 (5%)
Query: 23 GLARA-----DCWLIEGDKGFVWLAICSQNQPPYEAIPQQINSTIVDLRLNENRIRSVQY 77
GLA+A DC G+K +A C+ E++P + + L L+ NR+ +
Sbjct: 14 GLAQACPEPCDC----GEKYGFQIADCAYRD--LESVPPGFPANVTTLSLSANRLPGLPE 67
Query: 78 ASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRLRNLTEGMLRGLGKLEYL 137
+ L L L NEI + GA + +L+ L L +N + + L L L+ L
Sbjct: 68 GAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLL 127
Query: 138 YLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLNSGTFAGLAKLSVCELYSNPFYCSCE 197
+ +N + + +F + ++ L+ NR+ L GTF L LS ++ NPF C+C
Sbjct: 128 KMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCG 187
Query: 198 LLGFLRWLAAFTNATQTYDRMQCESPPVYSG 228
++ W + D + C SP V G
Sbjct: 188 IVWLKTWALTTAVSIPEQDNIACTSPHVLKG 218
>gi|51317373 netrin-G1 ligand [Homo sapiens]
Length = 640
Score = 77.8 bits (190), Expect = 4e-14
Identities = 58/181 (32%), Positives = 89/181 (49%), Gaps = 4/181 (2%)
Query: 9 LWVCVAAATLLHAGGLARAD-CWLIEGDKGFVWLAICSQNQPPYEAIPQQINSTIVDLRL 67
L V + A LL GL RA C + IC + +P I++ L L
Sbjct: 26 LLVVLLALQLLVVAGLVRAQTCPSVCSCSNQFSKVICVRKN--LREVPDGISTNTRLLNL 83
Query: 68 NENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRLRNLTEGM 127
+EN+I+ ++ S +L L L++N I IE GAF+G NL L+L NRL + G
Sbjct: 84 HENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGA 143
Query: 128 LRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDL-SMNRIQQLNSGTFAGLAKLSVCE 186
L KL+ L+L+ N IE + + +F P++ +DL + R+ ++ G F GL+ L
Sbjct: 144 FVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLN 203
Query: 187 L 187
L
Sbjct: 204 L 204
Score = 70.5 bits (171), Expect = 6e-12
Identities = 55/195 (28%), Positives = 90/195 (46%), Gaps = 24/195 (12%)
Query: 60 STIVDLRLNENRIRSVQYASLSRFGNLTYLNLTK-NEIGYIEDGAFSGQFNLQVLQLGYN 118
S + +L L N I S+ + +R +L L+L + + YI +GAF G NL+ L L
Sbjct: 148 SKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMC 207
Query: 119 RLR---NLTE-------------------GMLRGLGKLEYLYLQANLIEVVMASSFWECP 156
LR NLT G +GL L+ L++ + I+V+ ++F
Sbjct: 208 NLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQ 267
Query: 157 NIVNIDLSMNRIQQLNSGTFAGLAKLSVCELYSNPFYCSCELLGFLRWLAAFTNATQTYD 216
++V I+L+ N + L F L L L+ NP+ C+C++L +L W + T
Sbjct: 268 SLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDIL-WLSWWIKDMAPSNTAC 326
Query: 217 RMQCESPPVYSGYYL 231
+C +PP G Y+
Sbjct: 327 CARCNTPPNLKGRYI 341
Score = 40.0 bits (92), Expect = 0.009
Identities = 29/107 (27%), Positives = 46/107 (42%), Gaps = 24/107 (22%)
Query: 85 NLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRLRNLTEGMLRGLGKLEYLYLQANLI 144
N LNL +N+I I+ +F +L++LQL N +R + G GL
Sbjct: 77 NTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLA------------ 124
Query: 145 EVVMASSFWECPNIVNIDLSMNRIQQLNSGTFAGLAKLSVCELYSNP 191
N+ ++L NR+ + +G F L+KL L +NP
Sbjct: 125 ------------NLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNP 159
>gi|10190722 leucine-rich repeats and transmembrane domains 1 [Homo
sapiens]
Length = 345
Score = 77.8 bits (190), Expect = 4e-14
Identities = 53/179 (29%), Positives = 80/179 (44%)
Query: 54 IPQQINSTIVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVL 113
IP + L L +N+I + + L LNL+ N + + GAF G +LQVL
Sbjct: 44 IPSHLPPQTRTLHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVL 103
Query: 114 QLGYNRLRNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLNS 173
L N L +L + L +L L L +N I + S N+ + + N++QQL+
Sbjct: 104 NLTQNSLLSLESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDR 163
Query: 174 GTFAGLAKLSVCELYSNPFYCSCELLGFLRWLAAFTNATQTYDRMQCESPPVYSGYYLL 232
+ + + L N + C+C LLG WL F D + CESP + G LL
Sbjct: 164 ALLESMPSVRLLLLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLL 222
>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
[Homo sapiens]
Length = 1065
Score = 77.0 bits (188), Expect = 7e-14
Identities = 42/126 (33%), Positives = 68/126 (53%)
Query: 65 LRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRLRNLT 124
L L NRI+ V+ + +L L + +N I ++DGAF G N++ L+L +N L +
Sbjct: 220 LELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVN 279
Query: 125 EGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLNSGTFAGLAKLSV 184
+G L GL L+ LY+ N IE + ++ C + +DLS N++ +L+ F GL+ L
Sbjct: 280 KGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLER 339
Query: 185 CELYSN 190
L N
Sbjct: 340 LNLGDN 345
Score = 56.6 bits (135), Expect = 9e-08
Identities = 42/143 (29%), Positives = 69/143 (48%), Gaps = 3/143 (2%)
Query: 49 PPYEAIPQQINSTIVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSG-Q 107
P A Q + L L+ N I ++ +S R L YLNL+ N I +E G F
Sbjct: 133 PEINAQALQFYPALESLDLSSNIISEIKTSSFPRM-QLKYLNLSNNRITTLEAGCFDNLS 191
Query: 108 FNLQVLQLGYNRLRNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNR 167
+L V++L NR+ + + + L L++L L+ N I++V +F ++ ++ + N
Sbjct: 192 SSLLVVKLNRNRMSMIPPKIFK-LPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNG 250
Query: 168 IQQLNSGTFAGLAKLSVCELYSN 190
I +L G F GL + EL N
Sbjct: 251 ISKLKDGAFFGLNNMEELELEHN 273
Score = 48.1 bits (113), Expect = 3e-05
Identities = 47/176 (26%), Positives = 74/176 (42%), Gaps = 30/176 (17%)
Query: 60 STIVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGY-IEDG--AFSGQFNLQVLQLG 116
S + L L +NR+ + NL L+L NEI + IED AF+G +L L L
Sbjct: 335 SLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQ 394
Query: 117 YNRLRNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLNSGTF 176
N+++++T+ GL LE+L L N I + ++F S +++L
Sbjct: 395 GNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAF-----------SQTHLKEL----- 438
Query: 177 AGLAKLSVCELYSNPFYCSCELLGFLRWLAAFTNATQTYDRMQCESPPVYSGYYLL 232
L ++ C C L L+WL N Q + C P +G +L
Sbjct: 439 ---------ILNTSSLLCDCHLKWLLQWLV--DNNFQHSVNVSCAHPEWLAGQSIL 483
Score = 45.1 bits (105), Expect = 3e-04
Identities = 40/130 (30%), Positives = 53/130 (40%), Gaps = 3/130 (2%)
Query: 64 DLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRLRNL 123
+L L N + V L L L +++N I I A+ L L L YN+L L
Sbjct: 267 ELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRL 326
Query: 124 TEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQ---QLNSGTFAGLA 180
E GL LE L L N + + F N+ +DL N I + S FAGL
Sbjct: 327 DESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLT 386
Query: 181 KLSVCELYSN 190
L+ L N
Sbjct: 387 SLTKLILQGN 396
Score = 33.9 bits (76), Expect = 0.64
Identities = 27/83 (32%), Positives = 42/83 (50%), Gaps = 2/83 (2%)
Query: 109 NLQVLQLGYNRLRNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRI 168
N+ +L L +N + + L+ LE L L +N+I + SSF + ++LS NRI
Sbjct: 121 NITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPRM-QLKYLNLSNNRI 179
Query: 169 QQLNSGTFAGL-AKLSVCELYSN 190
L +G F L + L V +L N
Sbjct: 180 TTLEAGCFDNLSSSLLVVKLNRN 202
>gi|239752702 PREDICTED: leucine rich repeat containing 38, partial
[Homo sapiens]
Length = 254
Score = 76.6 bits (187), Expect = 9e-14
Identities = 47/172 (27%), Positives = 76/172 (44%), Gaps = 1/172 (0%)
Query: 53 AIPQQINSTIVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQV 112
++P + L + NRI+ + +G+L YL+ N + +E+G FSG L
Sbjct: 9 SVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVF 68
Query: 113 LQLGYNRLRNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLN 172
L L YN L L G R G+L L L N + V +F ++ ++L+ N ++ L+
Sbjct: 69 LDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLS 128
Query: 173 SGTFAGLAKLSVCELYSNPFYCSCELLGFLRWLAA-FTNATQTYDRMQCESP 223
A L L L NP+ C C+ W+ + + D +QC P
Sbjct: 129 VAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLP 180
>gi|239747236 PREDICTED: leucine rich repeat containing 38 [Homo
sapiens]
Length = 408
Score = 76.6 bits (187), Expect = 9e-14
Identities = 47/172 (27%), Positives = 76/172 (44%), Gaps = 1/172 (0%)
Query: 53 AIPQQINSTIVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQV 112
++P + L + NRI+ + +G+L YL+ N + +E+G FSG L
Sbjct: 163 SVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVF 222
Query: 113 LQLGYNRLRNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLN 172
L L YN L L G R G+L L L N + V +F ++ ++L+ N ++ L+
Sbjct: 223 LDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLS 282
Query: 173 SGTFAGLAKLSVCELYSNPFYCSCELLGFLRWLAA-FTNATQTYDRMQCESP 223
A L L L NP+ C C+ W+ + + D +QC P
Sbjct: 283 VAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLP 334
Score = 32.3 bits (72), Expect = 1.8
Identities = 25/86 (29%), Positives = 35/86 (40%), Gaps = 5/86 (5%)
Query: 708 PGSHPAEP--PAPPGPPPPPPHEGLGRKASILEPLTRPRPR--DLAYSQLSPQYHSL-SY 762
PG+ P P P P P PH + R+ S+ EPL R R ++ SP +
Sbjct: 69 PGARPPRPGRPLAPRARQPVPHRAVPRQGSLREPLPSRRGRRGPPGHAPPSPSLRRRGAR 128
Query: 763 SSSPEYTCRASQSIWERFRLSRRRHK 788
+ P RA + RL R H+
Sbjct: 129 ALQPSAAARARARVPRGLRLHRPAHR 154
>gi|239741057 PREDICTED: leucine rich repeat containing 38 [Homo
sapiens]
Length = 408
Score = 76.6 bits (187), Expect = 9e-14
Identities = 47/172 (27%), Positives = 76/172 (44%), Gaps = 1/172 (0%)
Query: 53 AIPQQINSTIVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQV 112
++P + L + NRI+ + +G+L YL+ N + +E+G FSG L
Sbjct: 163 SVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVF 222
Query: 113 LQLGYNRLRNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLN 172
L L YN L L G R G+L L L N + V +F ++ ++L+ N ++ L+
Sbjct: 223 LDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLS 282
Query: 173 SGTFAGLAKLSVCELYSNPFYCSCELLGFLRWLAA-FTNATQTYDRMQCESP 223
A L L L NP+ C C+ W+ + + D +QC P
Sbjct: 283 VAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLP 334
Score = 32.3 bits (72), Expect = 1.8
Identities = 25/86 (29%), Positives = 35/86 (40%), Gaps = 5/86 (5%)
Query: 708 PGSHPAEP--PAPPGPPPPPPHEGLGRKASILEPLTRPRPR--DLAYSQLSPQYHSL-SY 762
PG+ P P P P P PH + R+ S+ EPL R R ++ SP +
Sbjct: 69 PGARPPRPGRPLAPRARQPVPHRAVPRQGSLREPLPSRRGRRGPPGHAPPSPSLRRRGAR 128
Query: 763 SSSPEYTCRASQSIWERFRLSRRRHK 788
+ P RA + RL R H+
Sbjct: 129 ALQPSAAARARARVPRGLRLHRPAHR 154
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 76.6 bits (187), Expect = 9e-14
Identities = 52/169 (30%), Positives = 78/169 (46%)
Query: 64 DLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRLRNL 123
+L L +N I S+ S L L L++N+I +I GAF+G L+ L L N L++L
Sbjct: 303 ELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDL 362
Query: 124 TEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLNSGTFAGLAKLS 183
+ R L L+ + LQ N + + + F ++ I L N+++ L G F L KL
Sbjct: 363 DGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLC 422
Query: 184 VCELYSNPFYCSCELLGFLRWLAAFTNATQTYDRMQCESPPVYSGYYLL 232
LY NP+ C ++L WL T C SP G L+
Sbjct: 423 ELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLI 471
Score = 65.9 bits (159), Expect = 2e-10
Identities = 44/131 (33%), Positives = 64/131 (48%)
Query: 60 STIVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNR 119
S + +L+L+ N + + + LT LNL KN + +I F NLQVL+L NR
Sbjct: 155 SNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENR 214
Query: 120 LRNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLNSGTFAGL 179
L ++ G GL L+ L LQ N I ++ F N+ + LS N I QL F L
Sbjct: 215 LTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQL 274
Query: 180 AKLSVCELYSN 190
+L+ L+ N
Sbjct: 275 PQLNRLTLFGN 285
Score = 62.8 bits (151), Expect = 1e-09
Identities = 38/135 (28%), Positives = 65/135 (48%), Gaps = 3/135 (2%)
Query: 53 AIPQQINSTIVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQV 112
A+P + + L++ I + + L L + KNE+ I GAF +L+
Sbjct: 52 AVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRY 111
Query: 113 LQLGYNRLRNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLN 172
L L N+L+ L G+ +GL LE L L +N + + + F +C N+ + L N ++ +
Sbjct: 112 LSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIP 171
Query: 173 SGTF---AGLAKLSV 184
G F GL KL++
Sbjct: 172 DGAFDHLVGLTKLNL 186
Score = 62.8 bits (151), Expect = 1e-09
Identities = 50/156 (32%), Positives = 67/156 (42%), Gaps = 4/156 (2%)
Query: 65 LRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRLRNLT 124
LRL ENR+ + + NL L L +N+IG + G F NLQ L L N + L
Sbjct: 208 LRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLP 267
Query: 125 EGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLNSGTFAGLAKLSV 184
+ L +L L L N ++ + F PN+ + L N I L F+ L +L V
Sbjct: 268 PSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQV 327
Query: 185 CELYSN--PFYCSCELLGF--LRWLAAFTNATQTYD 216
L N F G LR L+ TNA Q D
Sbjct: 328 LILSRNQISFISPGAFNGLTELRELSLHTNALQDLD 363
Score = 62.4 bits (150), Expect = 2e-09
Identities = 39/129 (30%), Positives = 59/129 (45%)
Query: 62 IVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRLR 121
+ L L +N + + GNL L L +N + I G F G NLQ L L N++
Sbjct: 181 LTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIG 240
Query: 122 NLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLNSGTFAGLAK 181
L+ G+ L+ LYL N I + S F + P + + L N +++L+ G F +
Sbjct: 241 LLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPN 300
Query: 182 LSVCELYSN 190
L LY N
Sbjct: 301 LRELWLYDN 309
Score = 59.3 bits (142), Expect = 1e-08
Identities = 37/148 (25%), Positives = 65/148 (43%), Gaps = 5/148 (3%)
Query: 43 ICSQNQPPYEAIPQQINSTIVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDG 102
I N+ P+ I S ++ LR+ +N + + + G+L YL+L N++ + G
Sbjct: 71 ITELNESPFLNI-----SALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIG 125
Query: 103 AFSGQFNLQVLQLGYNRLRNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNID 162
F G +L+ L L N+L + L+ L L N +E + +F + ++
Sbjct: 126 LFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLN 185
Query: 163 LSMNRIQQLNSGTFAGLAKLSVCELYSN 190
L N + ++ F L L V LY N
Sbjct: 186 LGKNSLTHISPRVFQHLGNLQVLRLYEN 213
Score = 46.6 bits (109), Expect = 9e-05
Identities = 34/132 (25%), Positives = 55/132 (41%)
Query: 59 NSTIVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYN 118
N + L L+ N I + + + L L L N + + G F NL+ L L N
Sbjct: 250 NHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDN 309
Query: 119 RLRNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLNSGTFAG 178
+ +L + + L +L+ L L N I + +F + + L N +Q L+ F
Sbjct: 310 HISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRM 369
Query: 179 LAKLSVCELYSN 190
LA L L +N
Sbjct: 370 LANLQNISLQNN 381
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,601,236
Number of Sequences: 37866
Number of extensions: 2213709
Number of successful extensions: 43092
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 505
Number of HSP's successfully gapped in prelim test: 510
Number of HSP's that attempted gapping in prelim test: 26174
Number of HSP's gapped (non-prelim): 13009
length of query: 828
length of database: 18,247,518
effective HSP length: 111
effective length of query: 717
effective length of database: 14,044,392
effective search space: 10069829064
effective search space used: 10069829064
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.