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Search of human proteins with 19115964
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|19115964 phospholipase C delta 3 [Homo sapiens]
(789 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|19115964 phospholipase C delta 3 [Homo sapiens] 1598 0.0
gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens] 760 0.0
gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens] 758 0.0
gi|14249340 phospholipase C, delta 4 [Homo sapiens] 712 0.0
gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens] 452 e-127
gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens] 452 e-127
gi|25188201 phospholipase C, zeta 1 [Homo sapiens] 435 e-122
gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens] 422 e-118
gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens] 421 e-117
gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens] 362 e-100
gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens] 362 e-100
gi|95147333 phospholipase C, beta 2 [Homo sapiens] 333 4e-91
gi|12083581 phosphoinositide-specific phospholipase C beta 1 iso... 307 2e-83
gi|33356544 phosphoinositide-specific phospholipase C beta 1 iso... 307 2e-83
gi|78499633 phospholipase C, eta 2 [Homo sapiens] 305 1e-82
gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens] 295 1e-79
gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens] 295 1e-79
gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens] 295 1e-79
gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens] 230 4e-60
gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens] 230 4e-60
gi|117320537 phospholipase C, gamma 2 [Homo sapiens] 230 4e-60
gi|11386139 phospholipase C beta 3 [Homo sapiens] 186 1e-46
gi|117168250 phospholipase C, epsilon 1 [Homo sapiens] 182 1e-45
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 49 2e-05
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 49 2e-05
gi|38570146 synaptotagmin VII [Homo sapiens] 45 3e-04
gi|4506067 protein kinase C, alpha [Homo sapiens] 44 6e-04
gi|13384594 protein kinase C, gamma [Homo sapiens] 44 8e-04
gi|7305053 myoferlin isoform a [Homo sapiens] 43 0.001
gi|21361499 SUMO1/sentrin/SMT3 specific protease 3 [Homo sapiens] 43 0.001
>gi|19115964 phospholipase C delta 3 [Homo sapiens]
Length = 789
Score = 1598 bits (4137), Expect = 0.0
Identities = 789/789 (100%), Positives = 789/789 (100%)
Query: 1 MLCGRWRRCRRPPEEPPVAAQVAAQVAAPVALPSPPTPSDGGTKRPGLRALKKMGLTEDE 60
MLCGRWRRCRRPPEEPPVAAQVAAQVAAPVALPSPPTPSDGGTKRPGLRALKKMGLTEDE
Sbjct: 1 MLCGRWRRCRRPPEEPPVAAQVAAQVAAPVALPSPPTPSDGGTKRPGLRALKKMGLTEDE 60
Query: 61 DVRAMLRGSRLRKIRSRTWHKERLYRLQEDGLSVWFQRRIPRAPSQHIFFVQHIEAVREG 120
DVRAMLRGSRLRKIRSRTWHKERLYRLQEDGLSVWFQRRIPRAPSQHIFFVQHIEAVREG
Sbjct: 61 DVRAMLRGSRLRKIRSRTWHKERLYRLQEDGLSVWFQRRIPRAPSQHIFFVQHIEAVREG 120
Query: 121 HQSEGLRRFGGAFAPARCLTIAFKGRRKNLDLAAPTAEEAQRWVRGLTKLRARLDAMSQR 180
HQSEGLRRFGGAFAPARCLTIAFKGRRKNLDLAAPTAEEAQRWVRGLTKLRARLDAMSQR
Sbjct: 121 HQSEGLRRFGGAFAPARCLTIAFKGRRKNLDLAAPTAEEAQRWVRGLTKLRARLDAMSQR 180
Query: 181 ERLDHWIHSYLHRADSNQDSKMSFKEIKSLLRMVNVDMNDMYAYLLFKECDHSNNDRLEG 240
ERLDHWIHSYLHRADSNQDSKMSFKEIKSLLRMVNVDMNDMYAYLLFKECDHSNNDRLEG
Sbjct: 181 ERLDHWIHSYLHRADSNQDSKMSFKEIKSLLRMVNVDMNDMYAYLLFKECDHSNNDRLEG 240
Query: 241 AEIEEFLRRLLKRPELEEIFHQYSGEDRVLSAPELLEFLEDQGEEGATLARAQQLIQTYE 300
AEIEEFLRRLLKRPELEEIFHQYSGEDRVLSAPELLEFLEDQGEEGATLARAQQLIQTYE
Sbjct: 241 AEIEEFLRRLLKRPELEEIFHQYSGEDRVLSAPELLEFLEDQGEEGATLARAQQLIQTYE 300
Query: 301 LNETAKQHELMTLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYFISSSHNTYLTDSQ 360
LNETAKQHELMTLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYFISSSHNTYLTDSQ
Sbjct: 301 LNETAKQHELMTLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYFISSSHNTYLTDSQ 360
Query: 361 IGGPSSTEAYVRAFAQGCRCVELDCWEGPGGEPVIYHGHTLTSKILFRDVVQAVRDHAFT 420
IGGPSSTEAYVRAFAQGCRCVELDCWEGPGGEPVIYHGHTLTSKILFRDVVQAVRDHAFT
Sbjct: 361 IGGPSSTEAYVRAFAQGCRCVELDCWEGPGGEPVIYHGHTLTSKILFRDVVQAVRDHAFT 420
Query: 421 LSPYPVILSLENHCGLEQQAAMARHLCTILGDMLVTQALDSPNPEELPSPEQLKGRVLVK 480
LSPYPVILSLENHCGLEQQAAMARHLCTILGDMLVTQALDSPNPEELPSPEQLKGRVLVK
Sbjct: 421 LSPYPVILSLENHCGLEQQAAMARHLCTILGDMLVTQALDSPNPEELPSPEQLKGRVLVK 480
Query: 481 GKKLPAARSEDGRALSDREEEEEDDEEEEEEVEAAAQRRLAKQISPELSALAVYCHATRL 540
GKKLPAARSEDGRALSDREEEEEDDEEEEEEVEAAAQRRLAKQISPELSALAVYCHATRL
Sbjct: 481 GKKLPAARSEDGRALSDREEEEEDDEEEEEEVEAAAQRRLAKQISPELSALAVYCHATRL 540
Query: 541 RTLHPAPNAPQPCQVSSLSERKAKKLIREAGNSFVRHNARQLTRVYPLGLRMNSANYSPQ 600
RTLHPAPNAPQPCQVSSLSERKAKKLIREAGNSFVRHNARQLTRVYPLGLRMNSANYSPQ
Sbjct: 541 RTLHPAPNAPQPCQVSSLSERKAKKLIREAGNSFVRHNARQLTRVYPLGLRMNSANYSPQ 600
Query: 601 EMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYVLKPACLRQPDSTFDPEYPGPPRT 660
EMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYVLKPACLRQPDSTFDPEYPGPPRT
Sbjct: 601 EMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYVLKPACLRQPDSTFDPEYPGPPRT 660
Query: 661 TLSIQVLTAQQLPKLNAEKPHSIVDPLVRIEIHGVPADCARQETDYVLNNGFNPRWGQTL 720
TLSIQVLTAQQLPKLNAEKPHSIVDPLVRIEIHGVPADCARQETDYVLNNGFNPRWGQTL
Sbjct: 661 TLSIQVLTAQQLPKLNAEKPHSIVDPLVRIEIHGVPADCARQETDYVLNNGFNPRWGQTL 720
Query: 721 QFQLRAPELALVRFVVEDYDATSPNDFVGQFTLPLSSLKQGYRHIHLLSKDGASLSPATL 780
QFQLRAPELALVRFVVEDYDATSPNDFVGQFTLPLSSLKQGYRHIHLLSKDGASLSPATL
Sbjct: 721 QFQLRAPELALVRFVVEDYDATSPNDFVGQFTLPLSSLKQGYRHIHLLSKDGASLSPATL 780
Query: 781 FIQIRIQRS 789
FIQIRIQRS
Sbjct: 781 FIQIRIQRS 789
>gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens]
Length = 777
Score = 760 bits (1962), Expect = 0.0
Identities = 382/750 (50%), Positives = 515/750 (68%), Gaps = 17/750 (2%)
Query: 52 KKMGLTEDEDVRAMLRGSRLRKIRSRTWHKERLYRLQEDGLSVWFQ-RRIPRAPSQHIFF 110
+++GL +DED++A+L+GS+L K++S +W +ER Y+LQED ++W + R++ R P +F
Sbjct: 30 RRLGLQDDEDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTIWQESRKVMRTPESQLFS 89
Query: 111 VQHIEAVREGHQSEGLRRFGGAFAPARCLTIAFKGRRKNLDLAAPTAEEAQRWVRGLTKL 170
++ I+ VR GH++EGL +F RC +I FK +R LDL AP+ +AQ WV GL K+
Sbjct: 90 IEDIQEVRMGHRTEGLEKFARDVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKI 149
Query: 171 RARLDAMSQRERLDHWIHSYLHRADSNQDSKMSFKEIKSLLRMVNVDMNDMYAYLLFKEC 230
+M QR++L HWIHS L +AD N+D+KMSFKE+++ L+ +N+ ++D YA +F+EC
Sbjct: 150 IHHSGSMDQRQKLQHWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFREC 209
Query: 231 DHSNNDRLEGAEIEEFLRRLLKRPELEEIFHQYSGEDRVLSAPELLEFLE-DQGEEGATL 289
DHS D LE EIE F + L +R E++ F + +G LS +L+ FL+ Q EE A
Sbjct: 210 DHSQTDSLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEAAGP 269
Query: 290 ARAQQLIQTYELNETAKQHELMTLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYFIS 349
A A LI+ YE +ETAK MT DGF+MYLLS +G+A H V+QDM QPL+HY +S
Sbjct: 270 ALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVS 329
Query: 350 SSHNTYLTDSQIGGPSSTEAYVRAFAQGCRCVELDCWEGPGGEPVIYHGHTLTSKILFRD 409
SSHNTYL + Q+ GPSSTEAY+RA +GCRC+ELDCW+GP EP+IYHG+T TSKILF D
Sbjct: 330 SSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCD 389
Query: 410 VVQAVRDHAFTLSPYPVILSLENHCGLEQQAAMARHLCTILGDMLVTQALDSPNPEELPS 469
V++A+RD+AF SPYPVILSLENHC LEQQ MARHL ILG ML+ + LD LPS
Sbjct: 390 VLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDGVT-NSLPS 448
Query: 470 PEQLKGRVLVKGKKLPAARSEDGRALSDREEEEEDDEEEEEEVEAAAQRRLAK------Q 523
PEQLKG++L+KGKKL G + ++DE E E EA R K +
Sbjct: 449 PEQLKGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRVQHKPKEDKLR 508
Query: 524 ISPELSALAVYCHATRLRTLHPAPNAPQPC--QVSSLSERKAKKLIREAGNSFVRHNARQ 581
++ ELS + +YC + +P P +++S SE +A +L++E+GN FVRHN
Sbjct: 509 LAQELSDMVIYCKSVHFGGF-SSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGH 567
Query: 582 LTRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYVLKPA 641
L+R+YP G R +S+NYSP EMWN GCQ+VALNFQTPG EMD+ GRF NG CGYVLKPA
Sbjct: 568 LSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPA 627
Query: 642 CLRQPDSTFDP----EYPGPPRTTLSIQVLTAQQLPKLNAEKPHSIVDPLVRIEIHGVPA 697
LR P+ TF+P + P R L+I+V++ QQLPK+N K +SIVDP V +EIHGV
Sbjct: 628 FLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKNK-NSIVDPKVTVEIHGVSR 686
Query: 698 DCARQETDYVLNNGFNPRWGQTLQFQLRAPELALVRFVVEDYDATSPNDFVGQFTLPLSS 757
D A ++T + NNGFNP W F++ P+LAL+RF+VEDYDA+S NDF+GQ T+PL+S
Sbjct: 687 DVASRQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNS 746
Query: 758 LKQGYRHIHLLSKDGASLSPATLFIQIRIQ 787
LKQGYRH+HL+SK+G ATLF++I +Q
Sbjct: 747 LKQGYRHVHLMSKNGDQHPSATLFVKISLQ 776
>gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens]
Length = 756
Score = 758 bits (1956), Expect = 0.0
Identities = 382/747 (51%), Positives = 512/747 (68%), Gaps = 17/747 (2%)
Query: 55 GLTEDEDVRAMLRGSRLRKIRSRTWHKERLYRLQEDGLSVWFQ-RRIPRAPSQHIFFVQH 113
GL +DED++A+L+GS+L K++S +W +ER Y+LQED ++W + R++ R P +F ++
Sbjct: 12 GLQDDEDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTIWQESRKVMRTPESQLFSIED 71
Query: 114 IEAVREGHQSEGLRRFGGAFAPARCLTIAFKGRRKNLDLAAPTAEEAQRWVRGLTKLRAR 173
I+ VR GH++EGL +F RC +I FK +R LDL AP+ +AQ WV GL K+
Sbjct: 72 IQEVRMGHRTEGLEKFARDVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKIIHH 131
Query: 174 LDAMSQRERLDHWIHSYLHRADSNQDSKMSFKEIKSLLRMVNVDMNDMYAYLLFKECDHS 233
+M QR++L HWIHS L +AD N+D+KMSFKE+++ L+ +N+ ++D YA +F+ECDHS
Sbjct: 132 SGSMDQRQKLQHWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFRECDHS 191
Query: 234 NNDRLEGAEIEEFLRRLLKRPELEEIFHQYSGEDRVLSAPELLEFLE-DQGEEGATLARA 292
D LE EIE F + L +R E++ F + +G LS +L+ FL+ Q EE A A A
Sbjct: 192 QTDSLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEAAGPALA 251
Query: 293 QQLIQTYELNETAKQHELMTLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYFISSSH 352
LI+ YE +ETAK MT DGF+MYLLS +G+A H V+QDM QPL+HY +SSSH
Sbjct: 252 LSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSH 311
Query: 353 NTYLTDSQIGGPSSTEAYVRAFAQGCRCVELDCWEGPGGEPVIYHGHTLTSKILFRDVVQ 412
NTYL + Q+ GPSSTEAY+RA +GCRC+ELDCW+GP EP+IYHG+T TSKILF DV++
Sbjct: 312 NTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLR 371
Query: 413 AVRDHAFTLSPYPVILSLENHCGLEQQAAMARHLCTILGDMLVTQALDSPNPEELPSPEQ 472
A+RD+AF SPYPVILSLENHC LEQQ MARHL ILG ML+ + LD LPSPEQ
Sbjct: 372 AIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDGVT-NSLPSPEQ 430
Query: 473 LKGRVLVKGKKLPAARSEDGRALSDREEEEEDDEEEEEEVEAAAQRRLAK------QISP 526
LKG++L+KGKKL G + ++DE E E EA R K +++
Sbjct: 431 LKGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRVQHKPKEDKLRLAQ 490
Query: 527 ELSALAVYCHATRLRTLHPAPNAPQPC--QVSSLSERKAKKLIREAGNSFVRHNARQLTR 584
ELS + +YC + +P P +++S SE +A +L++E+GN FVRHN L+R
Sbjct: 491 ELSDMVIYCKSVHFGGF-SSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSR 549
Query: 585 VYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYVLKPACLR 644
+YP G R +S+NYSP EMWN GCQ+VALNFQTPG EMD+ GRF NG CGYVLKPA LR
Sbjct: 550 IYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLR 609
Query: 645 QPDSTFDP----EYPGPPRTTLSIQVLTAQQLPKLNAEKPHSIVDPLVRIEIHGVPADCA 700
P+ TF+P + P R L+I+V++ QQLPK+N K +SIVDP V +EIHGV D A
Sbjct: 610 DPNGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKNK-NSIVDPKVTVEIHGVSRDVA 668
Query: 701 RQETDYVLNNGFNPRWGQTLQFQLRAPELALVRFVVEDYDATSPNDFVGQFTLPLSSLKQ 760
++T + NNGFNP W F++ P+LAL+RF+VEDYDA+S NDF+GQ T+PL+SLKQ
Sbjct: 669 SRQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQ 728
Query: 761 GYRHIHLLSKDGASLSPATLFIQIRIQ 787
GYRH+HL+SK+G ATLF++I +Q
Sbjct: 729 GYRHVHLMSKNGDQHPSATLFVKISLQ 755
>gi|14249340 phospholipase C, delta 4 [Homo sapiens]
Length = 762
Score = 712 bits (1838), Expect = 0.0
Identities = 369/747 (49%), Positives = 494/747 (66%), Gaps = 16/747 (2%)
Query: 56 LTEDEDVRAMLRGSRLRKIRSRTWHKERLYRLQEDGLSVWFQRRIPRAPSQHIFFVQHIE 115
LT D+D+ M G +RK+RS++W K R +RLQ DG++VW R+ R ++ F + +E
Sbjct: 9 LTTDQDLLLMQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQA-RGSAKPSFSISDVE 67
Query: 116 AVREGHQSEGLRRFGGAFAPARCLTIAFKGRRKNLDLAAPTAEEAQRWVRGLTKLRARLD 175
+R GH SE LR + TI F GRR NLDL A + EEAQ W+RGL L +
Sbjct: 68 TIRNGHDSELLRSLAEELPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLVDLVT 127
Query: 176 AMSQRERLDHWIHSYLHRADSNQDSKMSFKEIKSLLRMVNVDMNDMYAYLLFKECDHSNN 235
+M +ERLD W+ + R D NQD KMSF+E++ LL ++NV+M+ YA+ LF+ D S +
Sbjct: 128 SMDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLFQAADTSQS 187
Query: 236 DRLEGAEIEEFLRRLLKRPELEEIFHQYSGEDRVLSAPELLEFL-EDQGEEGATLARAQQ 294
LEG E +F + L KR E++E+F +S + + L+ E L+FL E+Q E T A +
Sbjct: 188 GTLEGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELALE 247
Query: 295 LIQTYELNETAKQHELMTLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYFISSSHNT 354
LI YE +++ K ++++DGF+ YL S +G + ++QDM QPL HYFI SSHNT
Sbjct: 248 LIDRYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSSHNT 307
Query: 355 YLTDSQIGGPSSTEAYVRAFAQGCRCVELDCWEGPGGEPVIYHGHTLTSKILFRDVVQAV 414
YL Q+ G SS E Y+RA +GCRCVE+D W+GP GEPV+YHGHTLTS+ILF+DVV V
Sbjct: 308 YLVGDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSGEPVVYHGHTLTSRILFKDVVATV 367
Query: 415 RDHAFTLSPYPVILSLENHCGLEQQAAMARHLCTILGDMLVTQALDSPNPEELPSPEQLK 474
+AF S YPVILSLE HC EQQ MARHL ILG+ L++ LD P +LPSPE+L+
Sbjct: 368 AQYAFQTSDYPVILSLETHCSWEQQQTMARHLTEILGEQLLSTTLDGVLPTQLPSPEELR 427
Query: 475 GRVLVKGKKLPAARS---EDGRALSDREEE--------EEDDEEEEEEVEAAAQRRLAKQ 523
++LVKGKKL E+ A + EE E + E +E+ ++ +++ +K
Sbjct: 428 RKILVKGKKLTLEEDLEYEEEEAEPELEESELALESQFETEPEPQEQNLQNKDKKKKSKP 487
Query: 524 I-SPELSALAVYCHATRLRTLHPAPNAPQPCQVSSLSERKAKKLIREAGNSFVRHNARQL 582
I P LS+L +Y + R+ + ++SS SE KAK+LI+EAGN FV+HN QL
Sbjct: 488 ILCPALSSLVIYLKSVSFRSFTHSKEHYHFYEISSFSETKAKRLIKEAGNEFVQHNTWQL 547
Query: 583 TRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYVLKPAC 642
+RVYP GLR +S+NY+PQE+WN+GCQ+VA+N QT G EMD+ G F NG CGYVLKP
Sbjct: 548 SRVYPSGLRTDSSNYNPQELWNAGCQMVAMNMQTAGLEMDICDGHFRQNGGCGYVLKPDF 607
Query: 643 LRQPDSTFDPEYPGPP--RTTLSIQVLTAQQLPKLNAEKPHSIVDPLVRIEIHGVPADCA 700
LR S+F PE P P TL IQV++ QQLPK++ K SIVDPLV+++I GV D A
Sbjct: 608 LRDIQSSFHPEKPISPFKAQTLLIQVISGQQLPKVDKTKEGSIVDPLVKVQIFGVRLDTA 667
Query: 701 RQETDYVLNNGFNPRWGQTLQFQLRAPELALVRFVVEDYDATSPNDFVGQFTLPLSSLKQ 760
RQET+YV NNGFNP WGQTL F++ PELA++RFVV DYD S NDF+GQ+TLP + ++Q
Sbjct: 668 RQETNYVENNGFNPYWGQTLCFRVLVPELAMLRFVVMDYDWKSRNDFIGQYTLPWTCMQQ 727
Query: 761 GYRHIHLLSKDGASLSPATLFIQIRIQ 787
GYRHIHLLSKDG SL PA++F+ I IQ
Sbjct: 728 GYRHIHLLSKDGISLRPASIFVYICIQ 754
>gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens]
Length = 1127
Score = 452 bits (1163), Expect = e-127
Identities = 279/750 (37%), Positives = 408/750 (54%), Gaps = 34/750 (4%)
Query: 62 VRAMLRGSRLRKIRSRTWHKERLYRLQEDGLSVWFQRRIPRAPSQHIFFVQHIEAVREGH 121
+ +M+ GS L+K+RS + R + L D S+ ++ + I ++ I+ VR G
Sbjct: 140 INSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKID-IKSIKEVRTGK 198
Query: 122 QSEGLRRFG--GAFAPARCLTIAFKGRRKNLDLAAPTAEEAQRWVRGLTKL----RARLD 175
++ R G + ++ + ++LDL A +A+ A WV GL L + LD
Sbjct: 199 NTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLD 258
Query: 176 AM--SQRERLDHWIHSYLHRADSNQDSKMSFKEIKSLLRMVNVDMNDMYAYLLFKECDHS 233
+ SQ W+ D + ++ +R +N + L FKE H
Sbjct: 259 MLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKEL-HK 317
Query: 234 NNDRLEGAEI--EEFLR---RLLKRPELEEIFHQYSGEDRVLSAPELLEFLE-DQGEEGA 287
+ D+ G E+ EEF+ L RPE+ + Q+S L +L+ FLE +QG
Sbjct: 318 SKDKA-GTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHI 376
Query: 288 TLARAQQLIQTYELNETAKQHELMTLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYF 347
+ ++I YE ++ ++ +++DGF YL+SP+ D H V QDM QPL+HYF
Sbjct: 377 NEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYF 436
Query: 348 ISSSHNTYLTDSQIGGPSSTEAYVRAFAQGCRCVELDCWEGPGGEPVIYHGHTLTSKILF 407
I+SSHNTYL + Q GPS Y+RA GCR VELD W+GP EPVIY GHT+TS+I+F
Sbjct: 437 INSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVF 496
Query: 408 RDVVQAVRDHAFTLSPYPVILSLENHCGLEQQAAMARHLCTILGDMLVTQALDSPNPEE- 466
R V+ + +AF S YP+IL LENHC ++QQ M +H+ +LGD L T SPN EE
Sbjct: 497 RSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYT---TSPNVEES 553
Query: 467 -LPSPEQLKGRVLVKGKKLPAARSEDGRALSDREEEEEDDE----EEEEEVEAAAQRRLA 521
LPSP+ LKG++L+K KKL + S ++D +E E + E E+ +R
Sbjct: 554 YLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNNVPVKRF- 612
Query: 522 KQISPELSALAVYCHATRLRTLHPAPNAPQPCQVSSLSERKAKKLIREAGNSFVRHNARQ 581
Q+ ELS L C + + + + + +V S +E A K E FV +N R
Sbjct: 613 -QLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRF 671
Query: 582 LTRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYVLKPA 641
L RV+P +R++S+N +PQ+ W GCQ+VA+NFQTPG MDLN G F NG CGYVL+PA
Sbjct: 672 LARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPA 731
Query: 642 CLRQPDSTFD----PEYPGPPRTTLSIQVLTAQQLPK-LNAEKPHSIVDPLVRIEIHGVP 696
+R+ S F PG L I++++ Q PK + +VDP V +EIHG+P
Sbjct: 732 IMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIP 791
Query: 697 ADCARQETDYVLNNGFNPRWGQTLQFQLRAPELALVRFVVEDYDATSPNDFVGQFTLPLS 756
ADCA Q T V NG P + ++ +FQ+ PELA+VRFVV D D ++F+GQ+T+P
Sbjct: 792 ADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIG-DEFIGQYTIPFE 850
Query: 757 SLKQGYRHIHLLSKDGASLSPATLFIQIRI 786
L+ GYRH+ L S G L+ A+LF+ + I
Sbjct: 851 CLQTGYRHVPLQSLTGEVLAHASLFVHVAI 880
>gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens]
Length = 1001
Score = 452 bits (1163), Expect = e-127
Identities = 279/750 (37%), Positives = 408/750 (54%), Gaps = 34/750 (4%)
Query: 62 VRAMLRGSRLRKIRSRTWHKERLYRLQEDGLSVWFQRRIPRAPSQHIFFVQHIEAVREGH 121
+ +M+ GS L+K+RS + R + L D S+ ++ + I ++ I+ VR G
Sbjct: 14 INSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKID-IKSIKEVRTGK 72
Query: 122 QSEGLRRFG--GAFAPARCLTIAFKGRRKNLDLAAPTAEEAQRWVRGLTKL----RARLD 175
++ R G + ++ + ++LDL A +A+ A WV GL L + LD
Sbjct: 73 NTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLD 132
Query: 176 AM--SQRERLDHWIHSYLHRADSNQDSKMSFKEIKSLLRMVNVDMNDMYAYLLFKECDHS 233
+ SQ W+ D + ++ +R +N + L FKE H
Sbjct: 133 MLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKEL-HK 191
Query: 234 NNDRLEGAEI--EEFLR---RLLKRPELEEIFHQYSGEDRVLSAPELLEFLE-DQGEEGA 287
+ D+ G E+ EEF+ L RPE+ + Q+S L +L+ FLE +QG
Sbjct: 192 SKDKA-GTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHI 250
Query: 288 TLARAQQLIQTYELNETAKQHELMTLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYF 347
+ ++I YE ++ ++ +++DGF YL+SP+ D H V QDM QPL+HYF
Sbjct: 251 NEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYF 310
Query: 348 ISSSHNTYLTDSQIGGPSSTEAYVRAFAQGCRCVELDCWEGPGGEPVIYHGHTLTSKILF 407
I+SSHNTYL + Q GPS Y+RA GCR VELD W+GP EPVIY GHT+TS+I+F
Sbjct: 311 INSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVF 370
Query: 408 RDVVQAVRDHAFTLSPYPVILSLENHCGLEQQAAMARHLCTILGDMLVTQALDSPNPEE- 466
R V+ + +AF S YP+IL LENHC ++QQ M +H+ +LGD L T SPN EE
Sbjct: 371 RSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYT---TSPNVEES 427
Query: 467 -LPSPEQLKGRVLVKGKKLPAARSEDGRALSDREEEEEDDE----EEEEEVEAAAQRRLA 521
LPSP+ LKG++L+K KKL + S ++D +E E + E E+ +R
Sbjct: 428 YLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNNVPVKRF- 486
Query: 522 KQISPELSALAVYCHATRLRTLHPAPNAPQPCQVSSLSERKAKKLIREAGNSFVRHNARQ 581
Q+ ELS L C + + + + + +V S +E A K E FV +N R
Sbjct: 487 -QLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRF 545
Query: 582 LTRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYVLKPA 641
L RV+P +R++S+N +PQ+ W GCQ+VA+NFQTPG MDLN G F NG CGYVL+PA
Sbjct: 546 LARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPA 605
Query: 642 CLRQPDSTFD----PEYPGPPRTTLSIQVLTAQQLPK-LNAEKPHSIVDPLVRIEIHGVP 696
+R+ S F PG L I++++ Q PK + +VDP V +EIHG+P
Sbjct: 606 IMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIP 665
Query: 697 ADCARQETDYVLNNGFNPRWGQTLQFQLRAPELALVRFVVEDYDATSPNDFVGQFTLPLS 756
ADCA Q T V NG P + ++ +FQ+ PELA+VRFVV D D ++F+GQ+T+P
Sbjct: 666 ADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIG-DEFIGQYTIPFE 724
Query: 757 SLKQGYRHIHLLSKDGASLSPATLFIQIRI 786
L+ GYRH+ L S G L+ A+LF+ + I
Sbjct: 725 CLQTGYRHVPLQSLTGEVLAHASLFVHVAI 754
>gi|25188201 phospholipase C, zeta 1 [Homo sapiens]
Length = 608
Score = 435 bits (1119), Expect = e-122
Identities = 241/597 (40%), Positives = 354/597 (59%), Gaps = 11/597 (1%)
Query: 195 DSNQDSKMSFKEIKSLLRMVNVDMNDMYAYLLFKECDHSNNDRLEGAEIEEFLRRLLKRP 254
D + K++ ++ + LL +++ + ++ +FK+ D R+ E R + R
Sbjct: 12 DDFRGGKINLEKTQRLLEKLDIRCSYIHVKQIFKDNDRLKQGRITIEEFRAIYRIITHRE 71
Query: 255 ELEEIFHQYSGEDRVLSAPELLEFL-EDQGEEGATLARAQQLIQTYELNETAKQHELMTL 313
E+ EIF+ YS ++L A L +FL ++Q + A A ++IQ YE E ++ M+L
Sbjct: 72 EIIEIFNTYSENRKILLASNLAQFLTQEQYAAEMSKAIAFEIIQKYEPIEEVRKAHQMSL 131
Query: 314 DGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYFISSSHNTYLTDSQIGGPSSTEAYVRA 373
+GF Y+ S E N V+QDM PL YFISSSHNTYL Q+ GPS YV A
Sbjct: 132 EGFTRYMDSRECLLFKNECRKVYQDMTHPLNDYFISSSHNTYLVSDQLLGPSDLWGYVSA 191
Query: 374 FAQGCRCVELDCWEGPGGEPVIYHGHTLTSKILFRDVVQAVRDHAFTLSPYPVILSLENH 433
+GCRC+E+DCW+G EPV+YHG+TLTSK+LF+ V+QA+ +AF S YPV+LSLENH
Sbjct: 192 LVKGCRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKTVIQAIHKYAFMTSDYPVVLSLENH 251
Query: 434 CGLEQQAAMARHLCTILGDMLVTQALDSPNPEELPSPEQLKGRVLVKGKKLPAARSEDGR 493
C QQ MA +L G+ L++ LD P+ LPSPE LK ++LVK KK+ + R
Sbjct: 252 CSTAQQEVMADNLQATFGESLLSDMLDD-FPDTLPSPEALKFKILVKNKKIGTLKETHER 310
Query: 494 ALSDREEEEEDDEEEEEEVEAAAQRRLAK----QISPELSALAVYCHATRLRTLHPAPNA 549
SD+ + +D E +++ + K +I+ LS L +Y A + ++ +
Sbjct: 311 KGSDKRGDNQDKETGVKKLPGVMLFKKKKTRKLKIALALSDLVIYTKAEKFKSFQHSRLY 370
Query: 550 PQPCQVSSLSERKAKKLIREAGNSFVRHNARQLTRVYPLGLRMNSANYSPQEMWNSGCQL 609
Q + +S+ E +A+KL + + F+ H + +TR+YP R +S+N++PQE WN GCQ+
Sbjct: 371 QQFNENNSIGETQARKLSKLRVHEFIFHTRKFITRIYPKATRADSSNFNPQEFWNIGCQM 430
Query: 610 VALNFQTPGYEMDLNAGRFLVNGQCGYVLKPACLRQPDSTFDPE--YPGPPRTTLSIQVL 667
VALNFQTPG MDL G+FL NG GY+LKP LR+ S F+P G P TL+I+++
Sbjct: 431 VALNFQTPGLPMDLQNGKFLDNGGSGYILKPHFLRESKSYFNPSNIKEGMP-ITLTIRLI 489
Query: 668 TAQQLPKLNAEKPHSIVDPLVRIEIHGVPADCARQETDYVLNNGFNPRWGQTLQFQLRAP 727
+ QLP ++ D LV IE+ GVP D +Q+T + N F+PRW +T F + P
Sbjct: 490 SGIQLPLTHSSSNKG--DSLVIIEVFGVPNDQMKQQTRVIKKNAFSPRWNETFTFIIHVP 547
Query: 728 ELALVRFVVEDYDATSPNDFVGQFTLPLSSLKQGYRHIHLLSKDGASLSPATLFIQI 784
ELAL+RFVVE + N+F+GQ+TLPL + +GYR I L S+ G SL PA+LF+ +
Sbjct: 548 ELALIRFVVEGQGLIAGNEFLGQYTLPLLCMNKGYRRIPLFSRMGESLEPASLFVYV 604
>gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens]
Length = 1095
Score = 422 bits (1084), Expect = e-118
Identities = 279/790 (35%), Positives = 407/790 (51%), Gaps = 56/790 (7%)
Query: 32 LPSPPTPSDGGTKRP----GLRALKKMGLTEDEDVRAMLRGSRLRKIRSRTWHKERLYRL 87
+ P GG K+ + + KK+ D + M G L+K+R + R + L
Sbjct: 79 IKDPSNQKCGGRKKTVSFSSMPSEKKISSAND-CISFMQAGCELKKVRPNSRIYNRFFTL 137
Query: 88 QEDGLSVWFQ---RRIPRAPSQHIFFVQHIEAVREGHQSEGLRRFGGAFAPARCLTIAFK 144
D ++ ++ + + +A + I+ +R G +E R G A C AF
Sbjct: 138 DTDLQALRWEPSKKDLEKAKLD----ISAIKEIRLGKNTETFRNNG--LADQICEDCAFS 191
Query: 145 ----GRRKNLDLAAPTAEEAQRWVRGLTKLRAR----LDAMSQRERLDH--WIHSYLHRA 194
++LDL A +A+ A WV GL L +R LD M + W+ + A
Sbjct: 192 ILHGENYESLDLVANSADVANIWVSGLRYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAA 251
Query: 195 DSNQDSKMSFKEIKSLLRMVNVDMNDMYAYLLFKECDHSNNDRLEGAEIEEFLR---RLL 251
D + + M L++ +N + + L FKE S EEF L
Sbjct: 252 DVDGNGIMLEDTSVELIKQLNPTLKEAKIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELC 311
Query: 252 KRPELEEIFHQYSGEDRVLSAPELLEFLE-DQGEEGATLARAQQLIQTYELNETAKQHEL 310
RPE+ + Q S L A +L+ FLE +QG T +I+ YEL+E +Q
Sbjct: 312 TRPEVYFLLVQISKNKEYLDANDLMLFLEAEQGVTHITEDICLDIIRRYELSEEGRQKGF 371
Query: 311 MTLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYFISSSHNTYLTDSQIGGPSSTEAY 370
+ +DGF YLLS E D V QDM QPL+HY+I++SHNTYL + Q GP+ Y
Sbjct: 372 LAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYINASHNTYLIEDQFRGPADINGY 431
Query: 371 VRAFAQGCRCVELDCWEGPGGEPVIYHGHTLTSKILFRDVVQAVRDHAFTLSPYPVILSL 430
+RA GCR VELD +G EP++ + + +T+ + FR V++ + AF S YP+IL L
Sbjct: 432 IRALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSFRSVIEVINKFAFVASEYPLILCL 491
Query: 431 ENHCGLEQQAAMARHLCTILGDMLVTQALDSPNPEELPSPEQLKGRVLVKGKKLPAARSE 490
NHC L QQ MA+ + + G+ L T+A P+ LPSPE+LK ++VKGKKLP+
Sbjct: 492 GNHCSLPQQKVMAQQMKKVFGNKLYTEA-PLPSESYLPSPEKLKRMIIVKGKKLPSD--- 547
Query: 491 DGRALSDREEEEEDDEEEEEEVEAAAQRRLA-------KQI--SPELSALAVYCHATRLR 541
D E E DE+EE E+ RR++ KQI ELS L C + + R
Sbjct: 548 -----PDVLEGEVTDEDEEAEM----SRRMSVDYNGEQKQIRLCRELSDLVSICKSVQYR 598
Query: 542 TLHPAPNAPQPCQVSSLSERKAKKLIREAGNSFVRHNARQLTRVYPLGLRMNSANYSPQE 601
+ + ++ S SE +A ++ E FV +N + L+R+YP +R++S+N +PQ+
Sbjct: 599 DFELSMKSQNYWEMCSFSETEASRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQD 658
Query: 602 MWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYVLKPACLRQPDSTFDPE----YPGP 657
WN GCQ+VA+NFQTPG MDL+ G FL NG CGYVL+P+ +R S F PG
Sbjct: 659 FWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGILPGV 718
Query: 658 PRTTLSIQVLTAQQLPK-LNAEKPHSIVDPLVRIEIHGVPADCARQETDYVLNNGFNPRW 716
L I++++ Q PK A ++DP V IEIHG+PADC+ Q T V N NP +
Sbjct: 719 SPLALHIKIISGQNFPKPKGACAKGDVIDPYVCIEIHGIPADCSEQRTKTVQQNSDNPIF 778
Query: 717 GQTLQFQLRAPELALVRFVVEDYDATSPNDFVGQFTLPLSSLKQGYRHIHLLSKDGASLS 776
+T +FQ+ PELA++RFVV D D ++F+GQ+T+P L+ GYRH+ L S G +
Sbjct: 779 DETFEFQVNLPELAMIRFVVLDDDYIG-DEFIGQYTIPFECLQPGYRHVPLRSFVGDIME 837
Query: 777 PATLFIQIRI 786
TLF+ I I
Sbjct: 838 HVTLFVHIAI 847
>gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens]
Length = 997
Score = 421 bits (1081), Expect = e-117
Identities = 272/753 (36%), Positives = 394/753 (52%), Gaps = 51/753 (6%)
Query: 65 MLRGSRLRKIRSRTWHKERLYRLQEDGLSVWFQ---RRIPRAPSQHIFFVQHIEAVREGH 121
M G L+K+R + R + L D ++ ++ + + +A + I+ +R G
Sbjct: 17 MQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKLD----ISAIKEIRLGK 72
Query: 122 QSEGLRRFGGAFAPARCLTIAFK----GRRKNLDLAAPTAEEAQRWVRGLTKLRAR---- 173
+E R G A C AF ++LDL A +A+ A WV GL L +R
Sbjct: 73 NTETFRNNG--LADQICEDCAFSILHGENYESLDLVANSADVANIWVSGLRYLVSRSKQP 130
Query: 174 LDAMSQRERLDH--WIHSYLHRADSNQDSKMSFKEIKSLLRMVNVDMNDMYAYLLFKECD 231
LD M + W+ + AD + + M L++ +N + + L FKE
Sbjct: 131 LDFMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEAKIRLKFKEIQ 190
Query: 232 HSNNDRLEGAEIEEFLR---RLLKRPELEEIFHQYSGEDRVLSAPELLEFLE-DQGEEGA 287
S EEF L RPE+ + Q S L A +L+ FLE +QG
Sbjct: 191 KSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLFLEAEQGVTHI 250
Query: 288 TLARAQQLIQTYELNETAKQHELMTLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYF 347
T +I+ YEL+E +Q + +DGF YLLS E D V QDM QPL+HY+
Sbjct: 251 TEDICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYY 310
Query: 348 ISSSHNTYLTDSQIGGPSSTEAYVRAFAQGCRCVELDCWEGPGGEPVIYHGHTLTSKILF 407
I++SHNTYL + Q GP+ Y+RA GCR VELD +G EP++ + + +T+ + F
Sbjct: 311 INASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSF 370
Query: 408 RDVVQAVRDHAFTLSPYPVILSLENHCGLEQQAAMARHLCTILGDMLVTQALDSPNPEEL 467
R V++ + AF S YP+IL L NHC L QQ MA+ + + G+ L T+A P+ L
Sbjct: 371 RSVIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTEA-PLPSESYL 429
Query: 468 PSPEQLKGRVLVKGKKLPAARSEDGRALSDREEEEEDDEEEEEEVEAAAQRRLA------ 521
PSPE+LK ++VKGKKLP+ D E E DE+EE E+ RR++
Sbjct: 430 PSPEKLKRMIIVKGKKLPSD--------PDVLEGEVTDEDEEAEM----SRRMSVDYNGE 477
Query: 522 -KQI--SPELSALAVYCHATRLRTLHPAPNAPQPCQVSSLSERKAKKLIREAGNSFVRHN 578
KQI ELS L C + + R + + ++ S SE +A ++ E FV +N
Sbjct: 478 QKQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIANEYPEDFVNYN 537
Query: 579 ARQLTRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYVL 638
+ L+R+YP +R++S+N +PQ+ WN GCQ+VA+NFQTPG MDL+ G FL NG CGYVL
Sbjct: 538 KKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVL 597
Query: 639 KPACLRQPDSTFDPE----YPGPPRTTLSIQVLTAQQLPK-LNAEKPHSIVDPLVRIEIH 693
+P+ +R S F PG L I++++ Q PK A ++DP V IEIH
Sbjct: 598 RPSIMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCIEIH 657
Query: 694 GVPADCARQETDYVLNNGFNPRWGQTLQFQLRAPELALVRFVVEDYDATSPNDFVGQFTL 753
G+PADC+ Q T V N NP + +T +FQ+ PELA++RFVV D D ++F+GQ+T+
Sbjct: 658 GIPADCSEQRTKTVQQNSDNPIFDETFEFQVNLPELAMIRFVVLDDDYIG-DEFIGQYTI 716
Query: 754 PLSSLKQGYRHIHLLSKDGASLSPATLFIQIRI 786
P L+ GYRH+ L S G + TLF+ I I
Sbjct: 717 PFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAI 749
>gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens]
Length = 1194
Score = 362 bits (929), Expect = e-100
Identities = 247/723 (34%), Positives = 363/723 (50%), Gaps = 108/723 (14%)
Query: 152 LAAPTAEEAQRWVRGLTKL--RARLDAMSQRERLD-HWIHSYLHRADSNQDSKMSFKEIK 208
+ A E ++WV GL + R + +S L HW+ +N + K+ ++
Sbjct: 114 MVAENPEVTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFM---TNTNGKIP---VR 167
Query: 209 SLLRMVNVDMNDMYAYLLFKECD--HSNNDRLEGAEIE-----EFLRRLLKRPELEEIFH 261
S+ R + + KE ND +E E +++ R ++E++F
Sbjct: 168 SITRTFASGKTEKVIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFK 227
Query: 262 QYSGEDR-VLSAPELLEFLEDQGEEGAT---------LARAQQLIQTYELNETAKQHELM 311
+ +G+ L+ +L+ FL + + RA Q+I+ YE +E K+ L+
Sbjct: 228 KINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLI 287
Query: 312 TLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYFISSSHNTYLTDSQIGGPSSTEAYV 371
+ DGF YL+S E A + ++Q+M+ PLAHYFISSSHNTYLT Q GG SS E Y
Sbjct: 288 SSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYR 347
Query: 372 RAFAQGCRCVELDCWEGPG--GEPVIYHGHTLTSKILFRDVVQAVRDHAFTLSPYPVILS 429
+ GCRCVELDCW+G G EP+I HG + + ILF+DV+QA+++ AF S YPVILS
Sbjct: 348 QVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILS 407
Query: 430 LENHCGLEQQAAMARHLCTILGDMLVTQALDSPNPE---ELPSPEQLKGRVLVKGKK--- 483
ENHC QQ M+++ + GD+L+ QAL+S E LPSP LK ++L+K K+
Sbjct: 408 FENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKP 467
Query: 484 ------LPAARS--EDGRALSDREEEEEDDEEE----EEEVEAAAQRRLAKQIS------ 525
L A RS E G + S E+D+EEE ++E EA + + ++S
Sbjct: 468 EVEKKQLEALRSMMEAGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGH 527
Query: 526 -----------------------------------PELSALAVYCHATRLRTLHPAPNAP 550
P LS + Y + + H A
Sbjct: 528 KEAVANSVKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERN 587
Query: 551 QPCQVSSLSERKAKKLIREAGNSFVRHNARQLTRVYPLGLRMNSANYSPQEMWNSGCQLV 610
+SS +E ++ FV +N RQ++R+YP G R++S+NY PQ WN+GCQ+V
Sbjct: 588 IHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMV 647
Query: 611 ALNFQTPGYEMDLNAGRFLVNGQCGYVLKPACLRQPDSTFDP--EYP--GPPRTTLSIQV 666
+LN+QTP M LN G+F NG CGY+LKP +R+PD TFDP E P G T S+QV
Sbjct: 648 SLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQV 707
Query: 667 LTAQQLPKLNAEKPHSIVDPLVRIEIHGVPADCARQE--TDYVLNNGFNPRWGQTLQFQL 724
++ Q L + V ++++G+P D R+E T V+NNG NP + + F
Sbjct: 708 ISGQFLSDKK-------IGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEE-SFVF 759
Query: 725 R---APELALVRFVVEDYDATSPNDFVGQFTLPLSSLKQGYRHIHLLSKDGASLSPATLF 781
R P+LA++R V D N +GQ LPL L+ GYRHI L ++ LS T+F
Sbjct: 760 RKVILPDLAVLRIAVYD----DNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIF 815
Query: 782 IQI 784
I
Sbjct: 816 CNI 818
>gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens]
Length = 1175
Score = 362 bits (929), Expect = e-100
Identities = 247/723 (34%), Positives = 363/723 (50%), Gaps = 108/723 (14%)
Query: 152 LAAPTAEEAQRWVRGLTKL--RARLDAMSQRERLD-HWIHSYLHRADSNQDSKMSFKEIK 208
+ A E ++WV GL + R + +S L HW+ +N + K+ ++
Sbjct: 114 MVAENPEVTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFM---TNTNGKIP---VR 167
Query: 209 SLLRMVNVDMNDMYAYLLFKECD--HSNNDRLEGAEIE-----EFLRRLLKRPELEEIFH 261
S+ R + + KE ND +E E +++ R ++E++F
Sbjct: 168 SITRTFASGKTEKVIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFK 227
Query: 262 QYSGEDR-VLSAPELLEFLEDQGEEGAT---------LARAQQLIQTYELNETAKQHELM 311
+ +G+ L+ +L+ FL + + RA Q+I+ YE +E K+ L+
Sbjct: 228 KINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLI 287
Query: 312 TLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYFISSSHNTYLTDSQIGGPSSTEAYV 371
+ DGF YL+S E A + ++Q+M+ PLAHYFISSSHNTYLT Q GG SS E Y
Sbjct: 288 SSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYR 347
Query: 372 RAFAQGCRCVELDCWEGPG--GEPVIYHGHTLTSKILFRDVVQAVRDHAFTLSPYPVILS 429
+ GCRCVELDCW+G G EP+I HG + + ILF+DV+QA+++ AF S YPVILS
Sbjct: 348 QVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILS 407
Query: 430 LENHCGLEQQAAMARHLCTILGDMLVTQALDSPNPE---ELPSPEQLKGRVLVKGKK--- 483
ENHC QQ M+++ + GD+L+ QAL+S E LPSP LK ++L+K K+
Sbjct: 408 FENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKP 467
Query: 484 ------LPAARS--EDGRALSDREEEEEDDEEE----EEEVEAAAQRRLAKQIS------ 525
L A RS E G + S E+D+EEE ++E EA + + ++S
Sbjct: 468 EVEKKQLEALRSMMEAGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGH 527
Query: 526 -----------------------------------PELSALAVYCHATRLRTLHPAPNAP 550
P LS + Y + + H A
Sbjct: 528 KEAVANSVKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERN 587
Query: 551 QPCQVSSLSERKAKKLIREAGNSFVRHNARQLTRVYPLGLRMNSANYSPQEMWNSGCQLV 610
+SS +E ++ FV +N RQ++R+YP G R++S+NY PQ WN+GCQ+V
Sbjct: 588 IHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMV 647
Query: 611 ALNFQTPGYEMDLNAGRFLVNGQCGYVLKPACLRQPDSTFDP--EYP--GPPRTTLSIQV 666
+LN+QTP M LN G+F NG CGY+LKP +R+PD TFDP E P G T S+QV
Sbjct: 648 SLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQV 707
Query: 667 LTAQQLPKLNAEKPHSIVDPLVRIEIHGVPADCARQE--TDYVLNNGFNPRWGQTLQFQL 724
++ Q L + V ++++G+P D R+E T V+NNG NP + + F
Sbjct: 708 ISGQFLSDKK-------IGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEE-SFVF 759
Query: 725 R---APELALVRFVVEDYDATSPNDFVGQFTLPLSSLKQGYRHIHLLSKDGASLSPATLF 781
R P+LA++R V D N +GQ LPL L+ GYRHI L ++ LS T+F
Sbjct: 760 RKVILPDLAVLRIAVYD----DNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIF 815
Query: 782 IQI 784
I
Sbjct: 816 CNI 818
>gi|95147333 phospholipase C, beta 2 [Homo sapiens]
Length = 1185
Score = 333 bits (854), Expect = 4e-91
Identities = 224/647 (34%), Positives = 322/647 (49%), Gaps = 77/647 (11%)
Query: 207 IKSLLRMVNVDMNDMYAYLLFKECDHSNNDRLEGAEIEE-----FLRRLLKRPELEEIFH 261
+K+ +M D + A L ND + + E FL L RPE++EIF
Sbjct: 167 VKNFFQMFPADRKRVEAALSACHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEIDEIFT 226
Query: 262 QYSGEDRVLSAPELLEFLEDQGEEGATLA----------RAQQLIQTYELNETAKQHELM 311
Y + + E L +Q + + L + Q LI YE + Q +
Sbjct: 227 SYHAKAKPYMTKEHLTKFINQKQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINAQRGQL 286
Query: 312 TLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYFISSSHNTYLTDSQIGGPSSTEAYV 371
+ +G + +L PE + L + DM QPL HYFI+SSHNTYLT Q G SS E Y
Sbjct: 287 SPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYR 346
Query: 372 RAFAQGCRCVELDCWEG--PGGEPVIYHGHTLTSKILFRDVVQAVRDHAFTLSPYPVILS 429
+ GCRCVELDCW+G P EP+I HG T+T+ I F++ ++A+ + AF SPYP+ILS
Sbjct: 347 QVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILS 406
Query: 430 LENHCGL-EQQAAMARHLCTILGDMLVTQALDS---PNPEELPSPEQLKGRVLVKGKKL- 484
ENH QQA MA + TI GDML+T+ L+ LPSPE L+G++L+K KK
Sbjct: 407 FENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQ 466
Query: 485 --------------------PAARSEDGRALSDRE----EEEEDDEEEEEEVEAAAQRRL 520
P+A + +G + E EEEE +EEEEEE + +
Sbjct: 467 FSGPTSSSKDTGGEAEGSSPPSAPAGEGTVWAGEEGTELEEEEVEEEEEEESGNLDEEEI 526
Query: 521 AKQISPE------------LSALAVYCHATRLRTLHPAPNAPQPCQVSSLSERKAKKLIR 568
K S E +S+L Y T+ + + + +SS +E KA L+
Sbjct: 527 KKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLS 586
Query: 569 EAGNSFVRHNARQLTRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLNAGRF 628
+A FV +N RQ++R+YP G RM+S+NY PQ WN+GCQ+VALNFQT M N F
Sbjct: 587 KASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVF 646
Query: 629 LVNGQCGYVLKPACLRQPDSTFDP----EYPGPPRTTLSIQVLTAQQLPKLNAEKPHSIV 684
NGQ GY+LK +R+PD F+P TTLSI V++ Q L + + V
Sbjct: 647 EFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERS-------V 699
Query: 685 DPLVRIEIHGVPADCARQETDYV--LNNGFNPRWGQT--LQFQLRAPELALVRFVVEDYD 740
V +E+ G+P D R+ + N NP W + + ++ PELA +R V +
Sbjct: 700 RTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVME-- 757
Query: 741 ATSPNDFVGQFTLPLSSLKQGYRHIHLLSKDGASLSPATLFIQIRIQ 787
N F+G +P+++L GY H+ L S+ L+ LFI + ++
Sbjct: 758 --EGNKFLGHRIIPINALNSGYHHLCLHSESNMPLTMPALFIFLEMK 802
>gi|12083581 phosphoinositide-specific phospholipase C beta 1
isoform a [Homo sapiens]
Length = 1216
Score = 307 bits (787), Expect = 2e-83
Identities = 210/698 (30%), Positives = 348/698 (49%), Gaps = 76/698 (10%)
Query: 149 NLDLAAPTAEEAQRWVRGLTKLRARLDAMSQRERLDHWIHSYLHRADSNQDSKMSFK--- 205
+L+L A E A+ W + L L A + ++L +A + +++ +
Sbjct: 116 HLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSR------DAFLEKAYTKLKLQVTPEGRI 169
Query: 206 EIKSLLRMVNVDMNDMYAYLLFKECDHSNNDRLEGAEIEE-----FLRRLLKRPELEEIF 260
+K++ R+ + D + L S ND + + FL L RPE++ IF
Sbjct: 170 PLKNIYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIF 229
Query: 261 HQYSGEDR-VLSAPELLEFLEDQGEEGAT---------LARAQQLIQTYELNETAKQHEL 310
++ + + L+ ++++F+ + + + Q LI+ YE N + +
Sbjct: 230 SEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQ 289
Query: 311 MTLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYFISSSHNTYLTDSQIGGPSSTEAY 370
+++DGFM YL E + + +DM+QPL+HYFI+SSHNTYLT Q+ G SS E Y
Sbjct: 290 ISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMY 349
Query: 371 VRAFAQGCRCVELDCWEGPGGE--PVIYHGHTLTSKILFRDVVQAVRDHAFTLSPYPVIL 428
+ GCRCVELDCW+G E PVI HG T+T++I F++V++A+ + AF SP+P++L
Sbjct: 350 RQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILL 409
Query: 429 SLENHCGL-EQQAAMARHLCTILGDMLVTQALDSPNPEE---LPSPEQLKGRVLVKGKKL 484
S ENH +QQA MA + I GD L+ + L+ E LPSP L ++LVK KK
Sbjct: 410 SFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKK 469
Query: 485 PAARSEDG--RALSDR----------------------EEEEEDDEEEEEEVEAAAQRRL 520
SE + LS++ + E +DD+++++ +++
Sbjct: 470 SHKSSEGSGKKKLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGT 529
Query: 521 A---KQISPELSALAVYCHATRLRTLHPAPNAPQPCQVSSLSERKAKKLIREAGNSFVRH 577
A + E+S L Y + + + + ++SS E K + + ++ FV +
Sbjct: 530 AGSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEY 589
Query: 578 NARQLTRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYV 637
N QL+R+YP G R++S+NY PQ WN+GCQ+VALNFQT M +N G + NG+ GY
Sbjct: 590 NKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYR 649
Query: 638 LKPACLRQPDSTFDP----EYPGPPRTTLSIQVLTAQQLPKLNAEKPHSIVDPLVRIEIH 693
LKP +R+PD FDP G TLS+++++ Q L V V +++
Sbjct: 650 LKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKK-------VGTYVEVDMF 702
Query: 694 GVPADCARQ--ETDYVLNNGFNPRWGQ--TLQFQLRAPELALVRFVVEDYDATSPNDFVG 749
G+P D R+ +T N NP W + + ++ P LA +R V + F+G
Sbjct: 703 GLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPTLACLRIAVYE----EGGKFIG 758
Query: 750 QFTLPLSSLKQGYRHIHLLSKDGASLSPATLFIQIRIQ 787
LP+ +++ GY +I L ++ L+ +F+ I ++
Sbjct: 759 HRILPVQAIRPGYHYICLRNERNQPLTLPAVFVYIEVK 796
>gi|33356544 phosphoinositide-specific phospholipase C beta 1
isoform b [Homo sapiens]
Length = 1173
Score = 307 bits (787), Expect = 2e-83
Identities = 210/698 (30%), Positives = 348/698 (49%), Gaps = 76/698 (10%)
Query: 149 NLDLAAPTAEEAQRWVRGLTKLRARLDAMSQRERLDHWIHSYLHRADSNQDSKMSFK--- 205
+L+L A E A+ W + L L A + ++L +A + +++ +
Sbjct: 116 HLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSR------DAFLEKAYTKLKLQVTPEGRI 169
Query: 206 EIKSLLRMVNVDMNDMYAYLLFKECDHSNNDRLEGAEIEE-----FLRRLLKRPELEEIF 260
+K++ R+ + D + L S ND + + FL L RPE++ IF
Sbjct: 170 PLKNIYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIF 229
Query: 261 HQYSGEDR-VLSAPELLEFLEDQGEEGAT---------LARAQQLIQTYELNETAKQHEL 310
++ + + L+ ++++F+ + + + Q LI+ YE N + +
Sbjct: 230 SEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQ 289
Query: 311 MTLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYFISSSHNTYLTDSQIGGPSSTEAY 370
+++DGFM YL E + + +DM+QPL+HYFI+SSHNTYLT Q+ G SS E Y
Sbjct: 290 ISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMY 349
Query: 371 VRAFAQGCRCVELDCWEGPGGE--PVIYHGHTLTSKILFRDVVQAVRDHAFTLSPYPVIL 428
+ GCRCVELDCW+G E PVI HG T+T++I F++V++A+ + AF SP+P++L
Sbjct: 350 RQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILL 409
Query: 429 SLENHCGL-EQQAAMARHLCTILGDMLVTQALDSPNPEE---LPSPEQLKGRVLVKGKKL 484
S ENH +QQA MA + I GD L+ + L+ E LPSP L ++LVK KK
Sbjct: 410 SFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKK 469
Query: 485 PAARSEDG--RALSDR----------------------EEEEEDDEEEEEEVEAAAQRRL 520
SE + LS++ + E +DD+++++ +++
Sbjct: 470 SHKSSEGSGKKKLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGT 529
Query: 521 A---KQISPELSALAVYCHATRLRTLHPAPNAPQPCQVSSLSERKAKKLIREAGNSFVRH 577
A + E+S L Y + + + + ++SS E K + + ++ FV +
Sbjct: 530 AGSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEY 589
Query: 578 NARQLTRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYV 637
N QL+R+YP G R++S+NY PQ WN+GCQ+VALNFQT M +N G + NG+ GY
Sbjct: 590 NKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYR 649
Query: 638 LKPACLRQPDSTFDP----EYPGPPRTTLSIQVLTAQQLPKLNAEKPHSIVDPLVRIEIH 693
LKP +R+PD FDP G TLS+++++ Q L V V +++
Sbjct: 650 LKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKK-------VGTYVEVDMF 702
Query: 694 GVPADCARQ--ETDYVLNNGFNPRWGQ--TLQFQLRAPELALVRFVVEDYDATSPNDFVG 749
G+P D R+ +T N NP W + + ++ P LA +R V + F+G
Sbjct: 703 GLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPTLACLRIAVYE----EGGKFIG 758
Query: 750 QFTLPLSSLKQGYRHIHLLSKDGASLSPATLFIQIRIQ 787
LP+ +++ GY +I L ++ L+ +F+ I ++
Sbjct: 759 HRILPVQAIRPGYHYICLRNERNQPLTLPAVFVYIEVK 796
>gi|78499633 phospholipase C, eta 2 [Homo sapiens]
Length = 1416
Score = 305 bits (780), Expect = 1e-82
Identities = 179/468 (38%), Positives = 260/468 (55%), Gaps = 15/468 (3%)
Query: 53 KMGLTEDEDVRAMLRGSRLRKIRSRTWHKERLYRLQEDGLSVWFQRRIPRAPSQHIFFVQ 112
++G + + AM G ++ K+R + R Y L E + + R R + +
Sbjct: 37 QLGPLVERCMGAMQEGMQMVKLRGGSKGLVRFYYLDEHRSCIRW--RPSRKNEKAKISID 94
Query: 113 HIEAVREGHQSEGLRRF-GGAFAPARCLTIAFKGRRKNLDLAAPTAEEAQRWVRGLTKLR 171
I+ V EG QSE +R+ G+F P C +I R++LDL + ++E A+ WV GL L
Sbjct: 95 SIQEVSEGRQSEVFQRYPDGSFDPNCCFSIYHGSHRESLDLVSTSSEVARTWVTGLRYLM 154
Query: 172 ARL---DAMSQRERL-DHWIHSYLHRADSNQDSKMSFKEIKSLLRMVNVDMNDMYAYLLF 227
A + D++++R+R D W+ AD N D +S E+ LL +NV++ +F
Sbjct: 155 AGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSIGEVLQLLHKLNVNLPRQRVKQMF 214
Query: 228 KECDHSNNDRLEG-AEIEEFLRRLLKRPELEEIFHQYSGEDRVLSAPELLEFLE-DQGEE 285
+E D ++ G E F + + R +L + YS L A L FL+ +Q
Sbjct: 215 READTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDAASLQRFLQVEQKMA 274
Query: 286 GATLARAQQLIQTYELNETAKQHELMTLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAH 345
G TL Q +I+ +E K L+ +DGF Y SP G + H V QDM QPL+H
Sbjct: 275 GVTLESCQDIIEQFEPCPENKSKGLLGIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSH 334
Query: 346 YFISSSHNTYLTDSQIGGPSSTEAYVRAFAQGCRCVELDCWEGPGGEPVIYHGHTLTSKI 405
YFI+SSHNTYL Q+ S + Y GCRCVE+DCW+GP GEP+++HG+TLTSKI
Sbjct: 335 YFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKI 394
Query: 406 LFRDVVQAVRDHAFTLSPYPVILSLENHCGLEQQAAMARHLCTILGDMLVTQALDSPNPE 465
LF+DV++ + +AF + YPVILS+ENHC + QQ MA++L ILGD L ++ S +
Sbjct: 395 LFKDVIETINKYAFIKNEYPVILSIENHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDAT 454
Query: 466 ELPSPEQLKGRVLVKGKKLPAARSEDGRALSDREEEEEDDEEEEEEVE 513
LPSP+ LKG++LVKGKKLPA SED EE E DE+ +E++
Sbjct: 455 TLPSPQMLKGKILVKGKKLPANISEDA------EEGEVSDEDSADEID 496
Score = 214 bits (544), Expect = 3e-55
Identities = 117/298 (39%), Positives = 174/298 (58%), Gaps = 15/298 (5%)
Query: 488 RSEDGRALSDREEEEEDDEEEEE---EVEAAAQRRLAKQISPELSALAVYCHATRLRTLH 544
R + G L EE DE ++ + A +++ ++S LS L Y + +
Sbjct: 583 RKKKGSKLKKAASVEEGDEGQDSPGGQSRGATRQKKTMKLSRALSDLVKYTKSVATHDIE 642
Query: 545 PAPNAPQPCQVSSLSERKAKKLIREAGNSFVRHNARQLTRVYPLGLRMNSANYSPQEMWN 604
A QVSS SE KA +++++ ++R N +QL+R+YP R++S+NY+PQ WN
Sbjct: 643 M--EAASSWQVSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQPFWN 700
Query: 605 SGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYVLKPACLRQPDSTFDPE----YPGPPRT 660
+GCQ+VALN+Q+ G + LN +F NG CGYVLKP C+ Q F+P PG +
Sbjct: 701 AGCQMVALNYQSEGRMLQLNRAKFSANGGCGYVLKPGCMCQ--GVFNPNSEDPLPGQLKK 758
Query: 661 TLSIQVLTAQQLPKLNAE---KPHSIVDPLVRIEIHGVPADCARQETDYVLNNGFNPRWG 717
L +++++ QQLPK I+DP V +EI G+P DC+R++T V +NGFNP W
Sbjct: 759 QLVLRIISGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSREQTRVVDDNGFNPTWE 818
Query: 718 QTLQFQLRAPELALVRFVVEDYDATSPNDFVGQFTLPLSSLKQGYRHIHLLSKDGASL 775
+TL F + PE+ALVRF+V D+D DF+GQ TL SS+ GYRH++L + AS+
Sbjct: 819 ETLVFMVHMPEIALVRFLVWDHDPIG-RDFIGQRTLAFSSMMPGYRHVYLEGMEEASI 875
>gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens]
Length = 1002
Score = 295 bits (755), Expect = 1e-79
Identities = 171/463 (36%), Positives = 260/463 (56%), Gaps = 15/463 (3%)
Query: 65 MLRGSRLRKIRSRTWHKERLYRLQEDGLSVWFQRRIPRAPSQHIFFVQHIEAVREGHQSE 124
M G+++ K++ T RL+ L E + + R R + + I V EG QSE
Sbjct: 22 MQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRW--RPSRKSEKAKILIDSIYKVTEGRQSE 79
Query: 125 GLRRFG-GAFAPARCLTIAFKGRRKNLDLAAPTAEEAQRWVRGLTKLRARL---DAMSQR 180
R G F P+ C TI ++LDL EEA+ W+ GL L A + D++++R
Sbjct: 80 IFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKR 139
Query: 181 ERL-DHWIHSYLHRADSNQDSKMSFKEIKSLLRMVNVDMNDMYAYLLFKECDHSNND-RL 238
+R D W+ AD N D ++ +EI L+ +NV++ +F+E D N L
Sbjct: 140 QRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTL 199
Query: 239 EGAEIEEFLRRLLKRPELEEIFHQYSGEDRVLSAPELLEFLE-DQGEEGATLARAQQLIQ 297
E F + + R +L + YS + L+ EL +FL+ +Q T +I+
Sbjct: 200 TFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDIIK 259
Query: 298 TYELNETAKQHELMTLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYFISSSHNTYLT 357
+E++E K ++ ++GF ++ SP + H V+QDM+QPL +Y+I+SSHNTYLT
Sbjct: 260 KFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLT 319
Query: 358 DSQIGGPSSTEAYVRAFAQGCRCVELDCWEGPGGEPVIYHGHTLTSKILFRDVVQAVRDH 417
Q+ S + Y R +GCRCVE+DCW+GP GEPV++HG+TLTSKILFRDVV+ + H
Sbjct: 320 GDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKH 379
Query: 418 AFTLSPYPVILSLENHCGLEQQAAMARHLCTILGDMLVTQALDSPNPEELPSPEQLKGRV 477
AF + +PVILS+ENHC ++QQ +A++L I GD L ++D+ ++LPSP+ LKG++
Sbjct: 380 AFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGKI 439
Query: 478 LVKGKKLPAARSEDGRALSDREEEEEDDEEEEEEVEAAAQRRL 520
LVKGKKLP +D EE E DE+ +E+E + +L
Sbjct: 440 LVKGKKLPYHLGDDA------EEGEVSDEDSADEIEDECKFKL 476
Score = 209 bits (532), Expect = 8e-54
Identities = 127/339 (37%), Positives = 192/339 (56%), Gaps = 31/339 (9%)
Query: 463 NPEELPSPEQLKGRVLV----KGKKLPAARSEDGRALSDREEEEEDDEEEEEEVEAAAQR 518
+P+ S ++ GR L+ K KK +RS+ + D E+ ++ +E ++ +R
Sbjct: 533 SPDVKESGKKSHGRSLMTNFGKHKKTTKSRSKS-YSTDDEEDTQQSTGKEGGQLYRLGRR 591
Query: 519 RLAKQISPELSALAVYCHATRLRTLHPAPNAPQPCQVSSLSERKAKKLIREAGNSFVRHN 578
R ++ ELS L VY ++ + + V S SE +A +++++ F+ +N
Sbjct: 592 RKTMKLCRELSDLVVYTNSVAAQDIVDDGTTGN---VLSFSETRAHQVVQQKSEQFMIYN 648
Query: 579 ARQLTRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYVL 638
+QLTR+YP R++S+N++P WN+GCQLVALN+Q+ G M LN +F NG CGYVL
Sbjct: 649 QKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVL 708
Query: 639 KPACLRQPDSTFDP----EYPGPPRTTLSIQVLTAQQLPKLNAEKPHS-------IVDPL 687
KP + TF+P P P+ L ++V++ QQLPK P S I+DP
Sbjct: 709 KPQ--QMCKGTFNPFSGDPLPANPKKQLILKVISGQQLPK----PPDSMFGDRGEIIDPF 762
Query: 688 VRIEIHGVPADCARQETDYVLNNGFNPRWGQTLQFQLRAPELALVRFVVEDYDATSPNDF 747
V +EI G+P DC + +T V +NGFNP W +TL F + PE+ALVRF+V D+D DF
Sbjct: 763 VEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIG-RDF 821
Query: 748 VGQFTLPLSSLKQGYRHIHLLSKDGASLSPATLFIQIRI 786
VGQ T+ SSL GYRH++L L+ A++F+ I I
Sbjct: 822 VGQRTVTFSSLVPGYRHVYL-----EGLTEASIFVHITI 855
>gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens]
Length = 1693
Score = 295 bits (755), Expect = 1e-79
Identities = 171/463 (36%), Positives = 260/463 (56%), Gaps = 15/463 (3%)
Query: 65 MLRGSRLRKIRSRTWHKERLYRLQEDGLSVWFQRRIPRAPSQHIFFVQHIEAVREGHQSE 124
M G+++ K++ T RL+ L E + + R R + + I V EG QSE
Sbjct: 22 MQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRW--RPSRKSEKAKILIDSIYKVTEGRQSE 79
Query: 125 GLRRFG-GAFAPARCLTIAFKGRRKNLDLAAPTAEEAQRWVRGLTKLRARL---DAMSQR 180
R G F P+ C TI ++LDL EEA+ W+ GL L A + D++++R
Sbjct: 80 IFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKR 139
Query: 181 ERL-DHWIHSYLHRADSNQDSKMSFKEIKSLLRMVNVDMNDMYAYLLFKECDHSNND-RL 238
+R D W+ AD N D ++ +EI L+ +NV++ +F+E D N L
Sbjct: 140 QRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTL 199
Query: 239 EGAEIEEFLRRLLKRPELEEIFHQYSGEDRVLSAPELLEFLE-DQGEEGATLARAQQLIQ 297
E F + + R +L + YS + L+ EL +FL+ +Q T +I+
Sbjct: 200 TFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDIIK 259
Query: 298 TYELNETAKQHELMTLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYFISSSHNTYLT 357
+E++E K ++ ++GF ++ SP + H V+QDM+QPL +Y+I+SSHNTYLT
Sbjct: 260 KFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLT 319
Query: 358 DSQIGGPSSTEAYVRAFAQGCRCVELDCWEGPGGEPVIYHGHTLTSKILFRDVVQAVRDH 417
Q+ S + Y R +GCRCVE+DCW+GP GEPV++HG+TLTSKILFRDVV+ + H
Sbjct: 320 GDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKH 379
Query: 418 AFTLSPYPVILSLENHCGLEQQAAMARHLCTILGDMLVTQALDSPNPEELPSPEQLKGRV 477
AF + +PVILS+ENHC ++QQ +A++L I GD L ++D+ ++LPSP+ LKG++
Sbjct: 380 AFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGKI 439
Query: 478 LVKGKKLPAARSEDGRALSDREEEEEDDEEEEEEVEAAAQRRL 520
LVKGKKLP +D EE E DE+ +E+E + +L
Sbjct: 440 LVKGKKLPYHLGDDA------EEGEVSDEDSADEIEDECKFKL 476
Score = 209 bits (532), Expect = 8e-54
Identities = 127/339 (37%), Positives = 192/339 (56%), Gaps = 31/339 (9%)
Query: 463 NPEELPSPEQLKGRVLV----KGKKLPAARSEDGRALSDREEEEEDDEEEEEEVEAAAQR 518
+P+ S ++ GR L+ K KK +RS+ + D E+ ++ +E ++ +R
Sbjct: 533 SPDVKESGKKSHGRSLMTNFGKHKKTTKSRSKS-YSTDDEEDTQQSTGKEGGQLYRLGRR 591
Query: 519 RLAKQISPELSALAVYCHATRLRTLHPAPNAPQPCQVSSLSERKAKKLIREAGNSFVRHN 578
R ++ ELS L VY ++ + + V S SE +A +++++ F+ +N
Sbjct: 592 RKTMKLCRELSDLVVYTNSVAAQDIVDDGTTGN---VLSFSETRAHQVVQQKSEQFMIYN 648
Query: 579 ARQLTRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYVL 638
+QLTR+YP R++S+N++P WN+GCQLVALN+Q+ G M LN +F NG CGYVL
Sbjct: 649 QKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVL 708
Query: 639 KPACLRQPDSTFDP----EYPGPPRTTLSIQVLTAQQLPKLNAEKPHS-------IVDPL 687
KP + TF+P P P+ L ++V++ QQLPK P S I+DP
Sbjct: 709 KPQ--QMCKGTFNPFSGDPLPANPKKQLILKVISGQQLPK----PPDSMFGDRGEIIDPF 762
Query: 688 VRIEIHGVPADCARQETDYVLNNGFNPRWGQTLQFQLRAPELALVRFVVEDYDATSPNDF 747
V +EI G+P DC + +T V +NGFNP W +TL F + PE+ALVRF+V D+D DF
Sbjct: 763 VEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIG-RDF 821
Query: 748 VGQFTLPLSSLKQGYRHIHLLSKDGASLSPATLFIQIRI 786
VGQ T+ SSL GYRH++L L+ A++F+ I I
Sbjct: 822 VGQRTVTFSSLVPGYRHVYL-----EGLTEASIFVHITI 855
>gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens]
Length = 1655
Score = 295 bits (755), Expect = 1e-79
Identities = 171/463 (36%), Positives = 260/463 (56%), Gaps = 15/463 (3%)
Query: 65 MLRGSRLRKIRSRTWHKERLYRLQEDGLSVWFQRRIPRAPSQHIFFVQHIEAVREGHQSE 124
M G+++ K++ T RL+ L E + + R R + + I V EG QSE
Sbjct: 4 MQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRW--RPSRKSEKAKILIDSIYKVTEGRQSE 61
Query: 125 GLRRFG-GAFAPARCLTIAFKGRRKNLDLAAPTAEEAQRWVRGLTKLRARL---DAMSQR 180
R G F P+ C TI ++LDL EEA+ W+ GL L A + D++++R
Sbjct: 62 IFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKR 121
Query: 181 ERL-DHWIHSYLHRADSNQDSKMSFKEIKSLLRMVNVDMNDMYAYLLFKECDHSNND-RL 238
+R D W+ AD N D ++ +EI L+ +NV++ +F+E D N L
Sbjct: 122 QRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTL 181
Query: 239 EGAEIEEFLRRLLKRPELEEIFHQYSGEDRVLSAPELLEFLE-DQGEEGATLARAQQLIQ 297
E F + + R +L + YS + L+ EL +FL+ +Q T +I+
Sbjct: 182 TFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDIIK 241
Query: 298 TYELNETAKQHELMTLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYFISSSHNTYLT 357
+E++E K ++ ++GF ++ SP + H V+QDM+QPL +Y+I+SSHNTYLT
Sbjct: 242 KFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLT 301
Query: 358 DSQIGGPSSTEAYVRAFAQGCRCVELDCWEGPGGEPVIYHGHTLTSKILFRDVVQAVRDH 417
Q+ S + Y R +GCRCVE+DCW+GP GEPV++HG+TLTSKILFRDVV+ + H
Sbjct: 302 GDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKH 361
Query: 418 AFTLSPYPVILSLENHCGLEQQAAMARHLCTILGDMLVTQALDSPNPEELPSPEQLKGRV 477
AF + +PVILS+ENHC ++QQ +A++L I GD L ++D+ ++LPSP+ LKG++
Sbjct: 362 AFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGKI 421
Query: 478 LVKGKKLPAARSEDGRALSDREEEEEDDEEEEEEVEAAAQRRL 520
LVKGKKLP +D EE E DE+ +E+E + +L
Sbjct: 422 LVKGKKLPYHLGDDA------EEGEVSDEDSADEIEDECKFKL 458
Score = 209 bits (532), Expect = 8e-54
Identities = 127/339 (37%), Positives = 192/339 (56%), Gaps = 31/339 (9%)
Query: 463 NPEELPSPEQLKGRVLV----KGKKLPAARSEDGRALSDREEEEEDDEEEEEEVEAAAQR 518
+P+ S ++ GR L+ K KK +RS+ + D E+ ++ +E ++ +R
Sbjct: 515 SPDVKESGKKSHGRSLMTNFGKHKKTTKSRSKS-YSTDDEEDTQQSTGKEGGQLYRLGRR 573
Query: 519 RLAKQISPELSALAVYCHATRLRTLHPAPNAPQPCQVSSLSERKAKKLIREAGNSFVRHN 578
R ++ ELS L VY ++ + + V S SE +A +++++ F+ +N
Sbjct: 574 RKTMKLCRELSDLVVYTNSVAAQDIVDDGTTGN---VLSFSETRAHQVVQQKSEQFMIYN 630
Query: 579 ARQLTRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYVL 638
+QLTR+YP R++S+N++P WN+GCQLVALN+Q+ G M LN +F NG CGYVL
Sbjct: 631 QKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVL 690
Query: 639 KPACLRQPDSTFDP----EYPGPPRTTLSIQVLTAQQLPKLNAEKPHS-------IVDPL 687
KP + TF+P P P+ L ++V++ QQLPK P S I+DP
Sbjct: 691 KPQ--QMCKGTFNPFSGDPLPANPKKQLILKVISGQQLPK----PPDSMFGDRGEIIDPF 744
Query: 688 VRIEIHGVPADCARQETDYVLNNGFNPRWGQTLQFQLRAPELALVRFVVEDYDATSPNDF 747
V +EI G+P DC + +T V +NGFNP W +TL F + PE+ALVRF+V D+D DF
Sbjct: 745 VEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIG-RDF 803
Query: 748 VGQFTLPLSSLKQGYRHIHLLSKDGASLSPATLFIQIRI 786
VGQ T+ SSL GYRH++L L+ A++F+ I I
Sbjct: 804 VGQRTVTFSSLVPGYRHVYL-----EGLTEASIFVHITI 837
>gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens]
Length = 1291
Score = 230 bits (586), Expect = 4e-60
Identities = 145/404 (35%), Positives = 213/404 (52%), Gaps = 42/404 (10%)
Query: 111 VQHIEAVREGHQSEGLRRF--GGAFAP--ARCLTIAF--KGRRKNLDLAAPTAEEAQRWV 164
++ I+ +R G S R+ AF P + C I + + R K L L A + +E W+
Sbjct: 75 IREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWI 134
Query: 165 RGLTKLRARLDAMSQRERLDHWIHSYLHRADSNQDSKMSFKEIKSLLRMVNVDMNDM--- 221
+GLT L +++ W+ + D N++ ++S K++K++L VN + +M
Sbjct: 135 KGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFL 194
Query: 222 ---------------YAYL--LFKECDHSNNDRLEGAEIEEFLRRLLKRPELEEIFHQYS 264
Y L++ +S ++ +E R +RPEL +
Sbjct: 195 RERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRV----- 249
Query: 265 GEDRVLSAPELLEFLED-QGEEGATLARAQQLIQTYELNETAKQHE--LMTLDGFMMYLL 321
S PE +FL D QGE A Q L + ++ E LD F+ +L
Sbjct: 250 ------SLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVTFLF 303
Query: 322 SPEGAALDNTHTCVFQD-MNQPLAHYFISSSHNTYLTDSQIGGPSSTEAYVRAFAQGCRC 380
S E + ++ V D MN PL+HY+ISSSHNTYLT Q SS EAY R GCRC
Sbjct: 304 SKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRC 363
Query: 381 VELDCWEGPGGEPVIYHGHTLTSKILFRDVVQAVRDHAFTLSPYPVILSLENHCGLEQQA 440
+ELDCW+GP G PVIYHGHTLT+KI F DV+ +++HAF S YPVILS+E+HC + QQ
Sbjct: 364 IELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQR 423
Query: 441 AMARHLCTILGDMLVTQALDSPNPEELPSPEQLKGRVLVKGKKL 484
MA++ +LGD L+T+ ++ + + LPSP QLK ++L+K KKL
Sbjct: 424 NMAQYFKKVLGDTLLTKPVEI-SADGLPSPNQLKRKILIKHKKL 466
Score = 193 bits (490), Expect = 6e-49
Identities = 129/351 (36%), Positives = 179/351 (50%), Gaps = 21/351 (5%)
Query: 450 LGDMLVTQALDSPNPEELPSPEQLKGRVLVKGKKLPAARSEDGRALSDREEEEEDDEEEE 509
LGD+L LD P + PE R+ V + + +D +EE +D ++
Sbjct: 868 LGDLL-RGVLDVPACQIAIRPEGKNNRLFVFSISMASVAHWSLDVAADSQEELQDWVKKI 926
Query: 510 EEVEAAAQRRLA--------KQISPELSALAVYCHATRLRTLHPAPNAPQPCQVSSLSER 561
EV A RL K+I+ ELS L VYC +SS E
Sbjct: 927 REVAQTADARLTEGKIMERRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPET 986
Query: 562 KAKKLIREA-GNSFVRHNARQLTRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYE 620
KA+K + +A G F+++N QL+R+YP G R++S+NY P MW G QLVALNFQTP
Sbjct: 987 KAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKP 1046
Query: 621 MDLNAGRFLVNGQCGYVLKPACLRQPDSTFDP----EYPGPPRTTLSIQVLTAQQLPKLN 676
M +N F+ CGYVL+P+ +R D FDP G +SI+VL A+ LPK
Sbjct: 1047 MQMNQALFMTGRHCGYVLQPSTMR--DEAFDPFDKSSLRGLEPCAISIEVLGARHLPK-- 1102
Query: 677 AEKPHSIVDPLVRIEIHGVPADCARQETDYVLNNGFNPRW-GQTLQFQLRAPELALVRFV 735
IV P V IE+ G D +Q+T++V++NG NP W + FQ+ PE A +RFV
Sbjct: 1103 --NGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFV 1160
Query: 736 VEDYDATSPNDFVGQFTLPLSSLKQGYRHIHLLSKDGASLSPATLFIQIRI 786
V + D S +F+ Q T P+ LK GYR + L + L A+L I+I I
Sbjct: 1161 VYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDI 1211
>gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens]
Length = 1290
Score = 230 bits (586), Expect = 4e-60
Identities = 145/404 (35%), Positives = 213/404 (52%), Gaps = 42/404 (10%)
Query: 111 VQHIEAVREGHQSEGLRRF--GGAFAP--ARCLTIAF--KGRRKNLDLAAPTAEEAQRWV 164
++ I+ +R G S R+ AF P + C I + + R K L L A + +E W+
Sbjct: 75 IREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWI 134
Query: 165 RGLTKLRARLDAMSQRERLDHWIHSYLHRADSNQDSKMSFKEIKSLLRMVNVDMNDM--- 221
+GLT L +++ W+ + D N++ ++S K++K++L VN + +M
Sbjct: 135 KGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFL 194
Query: 222 ---------------YAYL--LFKECDHSNNDRLEGAEIEEFLRRLLKRPELEEIFHQYS 264
Y L++ +S ++ +E R +RPEL +
Sbjct: 195 RERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRV----- 249
Query: 265 GEDRVLSAPELLEFLED-QGEEGATLARAQQLIQTYELNETAKQHE--LMTLDGFMMYLL 321
S PE +FL D QGE A Q L + ++ E LD F+ +L
Sbjct: 250 ------SLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVTFLF 303
Query: 322 SPEGAALDNTHTCVFQD-MNQPLAHYFISSSHNTYLTDSQIGGPSSTEAYVRAFAQGCRC 380
S E + ++ V D MN PL+HY+ISSSHNTYLT Q SS EAY R GCRC
Sbjct: 304 SKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRC 363
Query: 381 VELDCWEGPGGEPVIYHGHTLTSKILFRDVVQAVRDHAFTLSPYPVILSLENHCGLEQQA 440
+ELDCW+GP G PVIYHGHTLT+KI F DV+ +++HAF S YPVILS+E+HC + QQ
Sbjct: 364 IELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQR 423
Query: 441 AMARHLCTILGDMLVTQALDSPNPEELPSPEQLKGRVLVKGKKL 484
MA++ +LGD L+T+ ++ + + LPSP QLK ++L+K KKL
Sbjct: 424 NMAQYFKKVLGDTLLTKPVEI-SADGLPSPNQLKRKILIKHKKL 466
Score = 193 bits (490), Expect = 6e-49
Identities = 129/351 (36%), Positives = 179/351 (50%), Gaps = 21/351 (5%)
Query: 450 LGDMLVTQALDSPNPEELPSPEQLKGRVLVKGKKLPAARSEDGRALSDREEEEEDDEEEE 509
LGD+L LD P + PE R+ V + + +D +EE +D ++
Sbjct: 868 LGDLL-RGVLDVPACQIAIRPEGKNNRLFVFSISMASVAHWSLDVAADSQEELQDWVKKI 926
Query: 510 EEVEAAAQRRLA--------KQISPELSALAVYCHATRLRTLHPAPNAPQPCQVSSLSER 561
EV A RL K+I+ ELS L VYC +SS E
Sbjct: 927 REVAQTADARLTEGKIMERRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPET 986
Query: 562 KAKKLIREA-GNSFVRHNARQLTRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYE 620
KA+K + +A G F+++N QL+R+YP G R++S+NY P MW G QLVALNFQTP
Sbjct: 987 KAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKP 1046
Query: 621 MDLNAGRFLVNGQCGYVLKPACLRQPDSTFDP----EYPGPPRTTLSIQVLTAQQLPKLN 676
M +N F+ CGYVL+P+ +R D FDP G +SI+VL A+ LPK
Sbjct: 1047 MQMNQALFMTGRHCGYVLQPSTMR--DEAFDPFDKSSLRGLEPCAISIEVLGARHLPK-- 1102
Query: 677 AEKPHSIVDPLVRIEIHGVPADCARQETDYVLNNGFNPRW-GQTLQFQLRAPELALVRFV 735
IV P V IE+ G D +Q+T++V++NG NP W + FQ+ PE A +RFV
Sbjct: 1103 --NGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFV 1160
Query: 736 VEDYDATSPNDFVGQFTLPLSSLKQGYRHIHLLSKDGASLSPATLFIQIRI 786
V + D S +F+ Q T P+ LK GYR + L + L A+L I+I I
Sbjct: 1161 VYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDI 1211
>gi|117320537 phospholipase C, gamma 2 [Homo sapiens]
Length = 1265
Score = 230 bits (586), Expect = 4e-60
Identities = 139/418 (33%), Positives = 224/418 (53%), Gaps = 25/418 (5%)
Query: 111 VQHIEAVREGHQSEGLRRFGGAFAPARCLTIAFKGRR---KNLDLAAPTAEEAQRWVRGL 167
+ I+ +R G S+ R C G + L LAA + E+A W+ GL
Sbjct: 67 IMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAVNWLSGL 126
Query: 168 TKLRARLDAMSQRERLDHWIHSYLHRADSNQDSKMSFKEIKSLLRMVNVDMNDMYAYLLF 227
L S ++ W+ ++ D + + +S +E+K++L ++N ++ +L
Sbjct: 127 KILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSA-KFLKD 185
Query: 228 KECD-HSNNDRLEGAEIEEFLRRLLKRPELEEIFHQYSGEDRVL----------SAPELL 276
K + ++ D L + F ++L+ + + I ++ + V SA L
Sbjct: 186 KFVEIGAHKDELSFEQFHLFYKKLMFEQQ-KSILDEFKKDSSVFILGNTDRPDASAVYLH 244
Query: 277 EF----LEDQGEEGATLARAQQLIQTYELNETAKQ--HELMTLDGFMMYLLSPEGAALDN 330
+F + +Q E A + T +++T ++ + +D F+ YL S E + D
Sbjct: 245 DFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDE 304
Query: 331 THTCV-FQDMNQPLAHYFISSSHNTYLTDSQIGGPSSTEAYVRAFAQGCRCVELDCWEGP 389
+ V QDMN PL+HY+ISSSHNTYLT Q+ SS EAY+R GCRC+ELDCW+GP
Sbjct: 305 KYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDCWDGP 364
Query: 390 GGEPVIYHGHTLTSKILFRDVVQAVRDHAFTLSPYPVILSLENHCGLEQQAAMARHLCTI 449
G+PVIYHG T T+KI F DVVQA++DHAF S +PVILS+E HC +EQQ MA+ +
Sbjct: 365 DGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKAFKEV 424
Query: 450 LGDMLVTQALDSPNPEELPSPEQLKGRVLVKGKKLPAARSEDGRALSDREEEEEDDEE 507
GD+L+T+ ++ + ++LPSP QL+ ++++K KKL R + + D+++E + E
Sbjct: 425 FGDLLLTKPTEA-SADQLPSPSQLREKIIIKHKKL-GPRGDVDVNMEDKKDEHKQQGE 480
Score = 155 bits (391), Expect = 2e-37
Identities = 99/267 (37%), Positives = 146/267 (54%), Gaps = 14/267 (5%)
Query: 522 KQISPELSALAVYCHATRLRTLHPAPNAPQPCQVSSLSERKAKKLIREAGNSFVRHNARQ 581
+ I+ ELS L VYC T +T N P ++ S E KA +IR+ +++N +
Sbjct: 924 QSIAIELSDLVVYCKPTS-KTKDNLEN-PDFREIRSFVETKADSIIRQKPVDLLKYNQKG 981
Query: 582 LTRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYVLKPA 641
LTRVYP G R++S+NY P +W G Q+VALNFQT M +N F +NG+ GYVL+P
Sbjct: 982 LTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPE 1041
Query: 642 CLRQPDSTFDPEYPGPPR---TTLSIQVLTAQQLPKLNAEKPHSIVDPLVRIEIHGVPAD 698
+R +DP P R TL+++VL A+ LPKL SI P V +EI G D
Sbjct: 1042 SMR--TEKYDPMPPESQRKILMTLTVKVLGARHLPKLG----RSIACPFVEVEICGAEYD 1095
Query: 699 CARQETDYVLNNGFNPRWGQT---LQFQLRAPELALVRFVVEDYDATSPNDFVGQFTLPL 755
+ +T V +NG +P W T + F++ P LA +RFVV + D S +F+ T P+
Sbjct: 1096 NNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPI 1155
Query: 756 SSLKQGYRHIHLLSKDGASLSPATLFI 782
++K G+R + L + + A+L +
Sbjct: 1156 KAVKSGFRSVPLKNGYSEDIELASLLV 1182
>gi|11386139 phospholipase C beta 3 [Homo sapiens]
Length = 1234
Score = 186 bits (471), Expect = 1e-46
Identities = 132/397 (33%), Positives = 201/397 (50%), Gaps = 41/397 (10%)
Query: 150 LDLAAPTAEEAQRWVRGLTKLRARLDAMSQRERLDHWIHSYLHRADS------NQDSKMS 203
L+ A + A+ W L KL + A + +++L +A + NQD ++
Sbjct: 118 LNFMAVQDDTAKVWSEELFKLAMNILAQNASR------NTFLRKAYTKLKLQVNQDGRIP 171
Query: 204 FKEIKSLLRMVNVDMNDMYAYL-----LFKECDHSNNDRLEGAEIEEFLRRLLKRPELEE 258
+K++L+M + D + L F + D E FL +L RP++++
Sbjct: 172 ---VKNILKMFSADKKRVETALESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRPDIDK 228
Query: 259 IFHQYSGEDR-VLSAPELLEFLEDQGEEGATL---------ARAQQLIQTYELNETAKQH 308
I + + + L+ +L++F+ + + ++A+ LI+ YE N+ +
Sbjct: 229 ILLEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLER 288
Query: 309 ELMTLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYFISSSHNTYLTDSQIGGPSSTE 368
+ M+++GF YL E L + DM QPL+ YFI+SSHNTYLT Q+ G SS E
Sbjct: 289 DQMSMEGFSRYLGGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVE 348
Query: 369 AYVRAFAQGCRCVELDCWEG--PGGEPVIYHGHTLTSKILFRDVVQAVRDHAFTLSPYPV 426
Y +A GCRCVELD W+G P EP I HG T+T+++ RDV++A+ + AF SPYPV
Sbjct: 349 MYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPV 408
Query: 427 ILSLENHC-GLEQQAAMARHLCTILGDMLVTQALDS---PNPEELPSPEQLKGRVLVKGK 482
ILS ENH +QQA MA + +I GD L+ + LD LPSP+ L GR+LVK K
Sbjct: 409 ILSFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNK 468
Query: 483 K--LPAARSEDGRALSDREEEEEDDEEEEEEVEAAAQ 517
K P+A D + R+ E E AA +
Sbjct: 469 KRHRPSAGGPDS---AGRKRPLEQSNSALSESSAATE 502
Score = 155 bits (391), Expect = 2e-37
Identities = 104/301 (34%), Positives = 155/301 (51%), Gaps = 27/301 (8%)
Query: 496 SDREEEEEDDEEEEEEV-------EAAAQRRLAKQISPELSALAVYCHATRLRTLHPAPN 548
+DRE+EEED+EEEE+ E A + + E+S L Y + ++ A
Sbjct: 553 ADREDEEEDEEEEEQTDPKKPTTDEGTASSEV--NATEEMSTLVNYIEPVKFKSFEAARK 610
Query: 549 APQPCQVSSLSERKAKKLIREAGNSFVRHNARQLTRVYPLGLRMNSANYSPQEMWNSGCQ 608
+ ++SS E KA + + ++ FV +N +QL+R+YP G R++S+NY PQ WN GCQ
Sbjct: 611 RNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQ 670
Query: 609 LVALNFQTPGYEMDLNAGRFLVNGQCGYVLKPACLRQPDSTFDP----EYPGPPRTTLSI 664
LVALNFQT M LNAG F NG+ GY+LKP +R+PD +FDP G L +
Sbjct: 671 LVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVANALRV 730
Query: 665 QVLTAQQLPKLNAEKPHSIVDPLVRIEIHGVPADCARQ-ETDYVLNNGFNPRWG-QTLQF 722
+V++ Q L V V +++ G+P D R+ T N FNP W + F
Sbjct: 731 KVISGQFLSDRK-------VGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFDF 783
Query: 723 -QLRAPELALVRFVVEDYDATSPNDFVGQFTLPLSSLKQGYRHIHLLSKDGASLSPATLF 781
++ P LA +R + FVG LP+S+++ GY ++ L ++ L L
Sbjct: 784 PKVVLPTLASLRIAAFE----EGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALL 839
Query: 782 I 782
I
Sbjct: 840 I 840
>gi|117168250 phospholipase C, epsilon 1 [Homo sapiens]
Length = 2302
Score = 182 bits (462), Expect = 1e-45
Identities = 103/263 (39%), Positives = 150/263 (57%), Gaps = 23/263 (8%)
Query: 274 ELLEFLEDQGEEGATLARAQQLIQTYELNETAKQHELMTLDGFMMYLLSPEGAALDNTHT 333
+L +FL + E T +IQ +E + + LM+ +GF +L+ E A N +
Sbjct: 1328 QLNDFLVNCQGEHCTYDEILSIIQKFEPSISMCHQGLMSFEGFARFLMDKENFASKNDES 1387
Query: 334 CV-FQDMNQPLAHYFISSSHNTYLTDSQIGGPSSTEAYVRAFAQGCRCVELDCWEGPGGE 392
+++ PL++Y+I SSHNTYLT Q+ G SS E Y + QGCR VELDCW+G G
Sbjct: 1388 QENIKELQLPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSVELDCWDGDDGM 1447
Query: 393 PVIYHGHTLTSKILFRDVVQAVRDHAFTLSPYPVILSLENHCGLEQQAAMARHLCTILGD 452
P+IYHGHTLT+KI F++VV+A+ AF S P+I+S+ENHC L QQ MA T+ G+
Sbjct: 1448 PIIYHGHTLTTKIPFKEVVEAIDRSAFINSDLPIIISIENHCSLPQQRKMAEIFKTVFGE 1507
Query: 453 MLVTQAL---DSPNPEELPSPEQLKGRVLVKGKKLPA-------------------ARSE 490
LVT+ L D + LPSP+QL+ +VL+K KKL A ++
Sbjct: 1508 KLVTKFLFETDFSDDPMLPSPDQLRKKVLLKNKKLKAHQTPVDILKQKAHQLASMQVQAY 1567
Query: 491 DGRALSDREEEEEDDEEEEEEVE 513
+G + R E++E+EE+E +
Sbjct: 1568 NGGNANPRPANNEEEEDEEDEYD 1590
Score = 132 bits (332), Expect = 1e-30
Identities = 79/243 (32%), Positives = 120/243 (49%), Gaps = 15/243 (6%)
Query: 550 PQPCQVSSLSERKAKKLIREAGNSFVRHNARQLTRVYPLGLRMNSANYSPQEMWNSGCQL 609
P+ +SSL+E AK+L R +H A QL R YP R++S+N +P W G QL
Sbjct: 1752 PKCYHISSLNENAAKRLCRRYSQKLTQHTACQLLRTYPAATRIDSSNPNPLMFWLHGIQL 1811
Query: 610 VALNFQTPGYEMDLNAGRFLVNGQCGYVLKPACL-------RQPDSTFDPEYPGPPRTTL 662
VALN+QT + LNA F NG CGYVLKP L Q S + +
Sbjct: 1812 VALNYQTDDLPLHLNAAMFEANGGCGYVLKPPVLWDKNCPMYQKFSPLERDLDSMDPAVY 1871
Query: 663 SIQVLTAQQLPKLNAEKPHSIVDPLVRIEIHGVPADCARQETDYVLNNGFNPRWGQTLQF 722
S+ +++ Q N +S+ P + +++ G+P D T + N NP W + F
Sbjct: 1872 SLTIVSGQ-----NVCPSNSMGSPCIEVDVLGMPLDSCHFRTKPIHRNTLNPMWNEQFLF 1926
Query: 723 QLRAPELALVRFVVEDYDATSPNDFVGQFTLPLSSLKQGYRHIHLLSKDGASLSPATLFI 782
+ +L +RF V + ++++ Q +PL +LK+GYRH+ L + L ++LFI
Sbjct: 1927 HVHFEDLVFLRFAVVENNSSA---VTAQRIIPLKALKRGYRHLQLRNLHNEVLEISSLFI 1983
Query: 783 QIR 785
R
Sbjct: 1984 NSR 1986
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 48.5 bits (114), Expect = 2e-05
Identities = 32/104 (30%), Positives = 56/104 (53%), Gaps = 7/104 (6%)
Query: 659 RTTLSIQVLTAQQLPKLNAEKPHSIVDPLVRIEIHGVPADCARQETDYVLNNGFNPRWGQ 718
R L + V A+ L ++ P+ + DP V++++ P ++Q+T + NP W +
Sbjct: 170 RDVLIVLVRDAKNLVPMD---PNGLSDPYVKLKLIPDPKSESKQKTK-TIKCSLNPEWNE 225
Query: 719 TLQFQLRAPELALVRFVVE--DYDATSPNDFVGQFTLPLSSLKQ 760
T +FQL+ + R VE D+D TS NDF+G + +S L++
Sbjct: 226 TFRFQLKESDKDR-RLSVEIWDWDLTSRNDFMGSLSFGISELQK 268
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 48.5 bits (114), Expect = 2e-05
Identities = 32/104 (30%), Positives = 56/104 (53%), Gaps = 7/104 (6%)
Query: 659 RTTLSIQVLTAQQLPKLNAEKPHSIVDPLVRIEIHGVPADCARQETDYVLNNGFNPRWGQ 718
R L + V A+ L ++ P+ + DP V++++ P ++Q+T + NP W +
Sbjct: 170 RDVLIVLVRDAKNLVPMD---PNGLSDPYVKLKLIPDPKSESKQKTK-TIKCSLNPEWNE 225
Query: 719 TLQFQLRAPELALVRFVVE--DYDATSPNDFVGQFTLPLSSLKQ 760
T +FQL+ + R VE D+D TS NDF+G + +S L++
Sbjct: 226 TFRFQLKESDKDR-RLSVEIWDWDLTSRNDFMGSLSFGISELQK 268
>gi|38570146 synaptotagmin VII [Homo sapiens]
Length = 403
Score = 45.1 bits (105), Expect = 3e-04
Identities = 32/102 (31%), Positives = 54/102 (52%), Gaps = 9/102 (8%)
Query: 660 TTLSIQVLTAQQLPKLNAEKPHSIVDPLVRIEIHGVPADCARQETDYVLNNGFNPRWGQT 719
+TL+++++ AQ+LP A+ DP V+I + +P + ET V NP W +T
Sbjct: 150 STLTVKIMKAQELP---AKDFSGTSDPFVKIYL--LPDKKHKLETK-VKRKNLNPHWNET 203
Query: 720 LQFQLRAPELALVRFV---VEDYDATSPNDFVGQFTLPLSSL 758
F+ E + R + V DYD S ND +G+ ++PL+ +
Sbjct: 204 FLFEGFPYEKVVQRILYLQVLDYDRFSRNDPIGEVSIPLNKV 245
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 43.9 bits (102), Expect = 6e-04
Identities = 27/94 (28%), Positives = 51/94 (54%), Gaps = 4/94 (4%)
Query: 667 LTAQQLPKLNAEKPHSIVDPLVRIEIHGVPADCARQETDYVLNNGFNPRWGQTLQFQLRA 726
+T + L P+ + DP V++++ P + ++Q+T + + NP+W ++ F+L+
Sbjct: 175 VTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTK-TIRSTLNPQWNESFTFKLK- 232
Query: 727 PELALVRFVVE--DYDATSPNDFVGQFTLPLSSL 758
P R VE D+D T+ NDF+G + +S L
Sbjct: 233 PSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSEL 266
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 43.5 bits (101), Expect = 8e-04
Identities = 32/108 (29%), Positives = 54/108 (50%), Gaps = 7/108 (6%)
Query: 653 EYPGPPRTTLSIQVLTAQQLPKLNAEKPHSIVDPLVRIEIHGVPADCARQETDYVLNNGF 712
E P + + V A+ L ++ P+ + DP V++++ P + +Q+T V
Sbjct: 164 EIRAPTADEIHVTVGEARNLIPMD---PNGLSDPYVKLKLIPDPRNLTKQKTRTVKAT-L 219
Query: 713 NPRWGQTLQFQLRAPELALVRFVVE--DYDATSPNDFVGQFTLPLSSL 758
NP W +T F L+ ++ R VE D+D TS NDF+G + +S L
Sbjct: 220 NPVWNETFVFNLKPGDVER-RLSVEVWDWDRTSRNDFMGAMSFGVSEL 266
>gi|7305053 myoferlin isoform a [Homo sapiens]
Length = 2061
Score = 43.1 bits (100), Expect = 0.001
Identities = 26/106 (24%), Positives = 47/106 (44%), Gaps = 8/106 (7%)
Query: 676 NAEKPHSIVDPLVRIEIHGVPADCARQETDYVLNNGFNPRWGQTLQFQLRAPELA-LVRF 734
NA+K + +VDP V + G ++ ++ NP W Q + Q++ P + ++
Sbjct: 388 NADKKN-LVDPFVEVSFAG------KKVCTNIIEKNANPEWNQVVNLQIKFPSVCEKIKL 440
Query: 735 VVEDYDATSPNDFVGQFTLPLSSLKQGYRHIHLLSKDGASLSPATL 780
+ D+D + ND VG L LS + + S G + T+
Sbjct: 441 TIYDWDRLTKNDVVGTTYLHLSKIAASGGEVEDFSSSGTGAASYTV 486
Score = 40.4 bits (93), Expect = 0.006
Identities = 33/120 (27%), Positives = 55/120 (45%), Gaps = 19/120 (15%)
Query: 662 LSIQVLTAQQLPKLNAEKPHSIVDPLVRIEIHGVPADCARQETDYVLNNGFNPRWGQTLQ 721
L + V +A +PK KP IV + + E +++T V +N NP W + L+
Sbjct: 2 LRVIVESASNIPKTKFGKPDPIVSVIFKDE---------KKKTKKV-DNELNPVWNEILE 51
Query: 722 FQLRAPEL---ALVRFVVEDYDATSPNDFVGQFTLPLSSL------KQGYRHIHLLSKDG 772
F LR L + + +V+D++ N +G T+ L L Y+ I LL++ G
Sbjct: 52 FDLRGIPLDFSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKG 111
Score = 35.8 bits (81), Expect = 0.16
Identities = 24/116 (20%), Positives = 49/116 (42%), Gaps = 13/116 (11%)
Query: 651 DPEYPGPPRTTLSIQVLTAQQLP---------KLNAEKPHSIVDPLVRIEIHGVPADCAR 701
DP P PPR + Q+ +L + + + DP ++I +
Sbjct: 1532 DPSVPAPPRQFRELPDSVPQECTVRIYIVRGLELQPQDNNGLCDPYIKITL----GKKVI 1587
Query: 702 QETDYVLNNGFNPRWGQTLQFQLRAPELALVRFVVEDYDATSPNDFVGQFTLPLSS 757
++ D+ + N NP +G+ + P+ ++ V DYD + ++ VG+ + L +
Sbjct: 1588 EDRDHYIPNTLNPVFGRMYELSCYLPQEKDLKISVYDYDTFTRDEKVGETIIDLEN 1643
>gi|21361499 SUMO1/sentrin/SMT3 specific protease 3 [Homo sapiens]
Length = 574
Score = 42.7 bits (99), Expect = 0.001
Identities = 36/128 (28%), Positives = 52/128 (40%), Gaps = 27/128 (21%)
Query: 455 VTQALDSPNPEELPSPEQLKGRV--------------LVKGKKLPAARSEDGRALSDREE 500
+ A SP E L P K R+ V ++LP R + S+ EE
Sbjct: 20 IPPAYSSPRRERLRWPPPPKPRLKSGGGFGPDPGSGTTVPARRLPVPRPSFDASASEEEE 79
Query: 501 EEEDDEEEEEEVEAAAQRRLAKQISPELSALAVYCHATRLRTLHPAPNAPQPCQVSSLSE 560
EEE++E+E+EE E AA R + P S L + P P+ P + S
Sbjct: 80 EEEEEEDEDEEEEVAAWR-----LPPRWSQLGT--------SQRPRPSRPTHRKTCSQRR 126
Query: 561 RKAKKLIR 568
R+A + R
Sbjct: 127 RRAMRAFR 134
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,161,780
Number of Sequences: 37866
Number of extensions: 1669037
Number of successful extensions: 19974
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 233
Number of HSP's successfully gapped in prelim test: 183
Number of HSP's that attempted gapping in prelim test: 14865
Number of HSP's gapped (non-prelim): 3001
length of query: 789
length of database: 18,247,518
effective HSP length: 110
effective length of query: 679
effective length of database: 14,082,258
effective search space: 9561853182
effective search space used: 9561853182
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.