Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 190343023
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|190343023 ATP-binding cassette, sub-family C, member 6
isoform 1 [Homo sapiens]
(1503 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|190343023 ATP-binding cassette, sub-family C, member 6 isofor... 2984 0.0
gi|239756495 PREDICTED: hypothetical protein [Homo sapiens] 2566 0.0
gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor... 1298 0.0
gi|134142340 ATP-binding cassette, sub-family C, member 1 isofor... 1179 0.0
gi|134142335 ATP-binding cassette, sub-family C, member 1 isofor... 1177 0.0
gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform ... 1171 0.0
gi|134142345 ATP-binding cassette, sub-family C, member 1 isofor... 1119 0.0
gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member... 999 0.0
gi|157502201 ATP-binding cassette, sub-family C, member 4 isofor... 674 0.0
gi|134142342 ATP-binding cassette, sub-family C, member 1 isofor... 637 0.0
gi|110832839 ATP-binding cassette, sub-family C, member 9 isofor... 611 e-174
gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo ... 608 e-173
gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo ... 603 e-172
gi|110832835 ATP-binding cassette, sub-family C, member 9 isofor... 600 e-171
gi|110832837 ATP-binding cassette, sub-family C, member 9 isofor... 599 e-171
gi|89111135 ATP-binding cassette protein C12 [Homo sapiens] 583 e-166
gi|21729873 ATP-binding cassette, sub-family C, member 11 isofor... 568 e-161
gi|15149474 ATP-binding cassette, sub-family C, member 11 isofor... 568 e-161
gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform... 530 e-150
gi|21729876 ATP-binding cassette, sub-family C, member 11 isofor... 519 e-146
gi|221316556 ATP-binding cassette, sub-family C, member 3 isofor... 369 e-101
gi|157502203 ATP-binding cassette, sub-family C, member 4 isofor... 362 2e-99
gi|90421313 cystic fibrosis transmembrane conductance regulator ... 252 2e-66
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 228 3e-59
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 221 3e-57
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo... 164 8e-40
gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Ho... 162 2e-39
gi|118582251 URG7 protein isoform 2 [Homo sapiens] 162 3e-39
gi|73747915 transporter 2, ATP-binding cassette, sub-family B is... 152 2e-36
gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member ... 143 1e-33
>gi|190343023 ATP-binding cassette, sub-family C, member 6 isoform 1
[Homo sapiens]
Length = 1503
Score = 2984 bits (7735), Expect = 0.0
Identities = 1503/1503 (100%), Positives = 1503/1503 (100%)
Query: 1 MAAPAEPCAGQGVWNQTEPEPAATSLLSLCFLRTAGVWVPPMYLWVLGPIYLLFIHHHGR 60
MAAPAEPCAGQGVWNQTEPEPAATSLLSLCFLRTAGVWVPPMYLWVLGPIYLLFIHHHGR
Sbjct: 1 MAAPAEPCAGQGVWNQTEPEPAATSLLSLCFLRTAGVWVPPMYLWVLGPIYLLFIHHHGR 60
Query: 61 GYLRMSPLFKAKMVLGFALIVLCTSSVAVALWKIQQGTPEAPEFLIHPTVWLTTMSFAVF 120
GYLRMSPLFKAKMVLGFALIVLCTSSVAVALWKIQQGTPEAPEFLIHPTVWLTTMSFAVF
Sbjct: 61 GYLRMSPLFKAKMVLGFALIVLCTSSVAVALWKIQQGTPEAPEFLIHPTVWLTTMSFAVF 120
Query: 121 LIHTERKKGVQSSGVLFGYWLLCFVLPATNAAQQASGAGFQSDPVRHLSTYLCLSLVVAQ 180
LIHTERKKGVQSSGVLFGYWLLCFVLPATNAAQQASGAGFQSDPVRHLSTYLCLSLVVAQ
Sbjct: 121 LIHTERKKGVQSSGVLFGYWLLCFVLPATNAAQQASGAGFQSDPVRHLSTYLCLSLVVAQ 180
Query: 181 FVLSCLADQPPFFPEDPQQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLG 240
FVLSCLADQPPFFPEDPQQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLG
Sbjct: 181 FVLSCLADQPPFFPEDPQQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLG 240
Query: 241 RENSSEELVSRLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLL 300
RENSSEELVSRLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLL
Sbjct: 241 RENSSEELVSRLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLL 300
Query: 301 KAIWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSA 360
KAIWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSA
Sbjct: 301 KAIWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSA 360
Query: 361 CLQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRL 420
CLQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRL
Sbjct: 361 CLQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRL 420
Query: 421 TESVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQ 480
TESVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQ
Sbjct: 421 TESVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQ 480
Query: 481 MRQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQ 540
MRQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQ
Sbjct: 481 MRQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQ 540
Query: 541 VSTFLVALVVFAVHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDR 600
VSTFLVALVVFAVHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDR
Sbjct: 541 VSTFLVALVVFAVHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDR 600
Query: 601 LVTFLCLEEVDPGVVDSSSSGSAAGKDCITIHSATFAWSQESPPCLHRINLTVPQGCLLA 660
LVTFLCLEEVDPGVVDSSSSGSAAGKDCITIHSATFAWSQESPPCLHRINLTVPQGCLLA
Sbjct: 601 LVTFLCLEEVDPGVVDSSSSGSAAGKDCITIHSATFAWSQESPPCLHRINLTVPQGCLLA 660
Query: 661 VVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPP 720
VVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPP
Sbjct: 661 VVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPP 720
Query: 721 WLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPL 780
WLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPL
Sbjct: 721 WLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPL 780
Query: 781 AALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQEL 840
AALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQEL
Sbjct: 781 AALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQEL 840
Query: 841 LQRKGALVCLLDQARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRT 900
LQRKGALVCLLDQARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRT
Sbjct: 841 LQRKGALVCLLDQARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRT 900
Query: 901 TSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKATVHLAYLRAVGTPLCLYALFLFLCQQVA 960
TSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKATVHLAYLRAVGTPLCLYALFLFLCQQVA
Sbjct: 901 TSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKATVHLAYLRAVGTPLCLYALFLFLCQQVA 960
Query: 961 SFCRGYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLL 1020
SFCRGYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLL
Sbjct: 961 SFCRGYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLL 1020
Query: 1021 FQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVV 1080
FQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVV
Sbjct: 1021 FQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVV 1080
Query: 1081 AVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAF 1140
AVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAF
Sbjct: 1081 AVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAF 1140
Query: 1141 RTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAG 1200
RTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAG
Sbjct: 1141 RTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAG 1200
Query: 1201 LVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWP 1260
LVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWP
Sbjct: 1201 LVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWP 1260
Query: 1261 QGGQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAE 1320
QGGQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAE
Sbjct: 1261 QGGQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAE 1320
Query: 1321 GGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQL 1380
GGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQL
Sbjct: 1321 GGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQL 1380
Query: 1381 KALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQM 1440
KALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQM
Sbjct: 1381 KALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQM 1440
Query: 1441 QAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQES 1500
QAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQES
Sbjct: 1441 QAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQES 1500
Query: 1501 GLV 1503
GLV
Sbjct: 1501 GLV 1503
>gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1312
Score = 2566 bits (6652), Expect = 0.0
Identities = 1301/1311 (99%), Positives = 1304/1311 (99%)
Query: 193 FPEDPQQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRL 252
F + +NPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRL
Sbjct: 2 FTFSTKYTNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRL 61
Query: 253 EKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFL 312
EKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFL
Sbjct: 62 EKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFL 121
Query: 313 LGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMY 372
LGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMY
Sbjct: 122 LGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMY 181
Query: 373 RLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWL 432
RLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWL
Sbjct: 182 RLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWL 241
Query: 433 PLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTS 492
PLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTS
Sbjct: 242 PLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTS 301
Query: 493 SILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFA 552
SILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFA
Sbjct: 302 SILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFA 361
Query: 553 VHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDP 612
VHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDP
Sbjct: 362 VHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDP 421
Query: 613 GVVDSSSSGSAAGKDCITIHSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSL 672
G VDSSSSGSAAGKDCITI SATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSL
Sbjct: 422 GAVDSSSSGSAAGKDCITIQSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSL 481
Query: 673 LSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQ 732
LSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQ
Sbjct: 482 LSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQ 541
Query: 733 PDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVF 792
PDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVF
Sbjct: 542 PDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVF 601
Query: 793 NQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLD 852
NQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLD
Sbjct: 602 NQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLD 661
Query: 853 QARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDD 912
QARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDD
Sbjct: 662 QARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDD 721
Query: 913 PDRAGWPAGKDSIQYGRVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLWA 972
PDRAGWPAGKDSIQYGRVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLWA
Sbjct: 722 PDRAGWPAGKDSIQYGRVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLWA 781
Query: 973 DDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSP 1032
DDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSP
Sbjct: 782 DDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSP 841
Query: 1033 ISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAIL 1092
ISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAIL
Sbjct: 842 ISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAIL 901
Query: 1093 PLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNA 1152
PLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNA
Sbjct: 902 PLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNA 961
Query: 1153 RVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQV 1212
RVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQV
Sbjct: 962 RVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQV 1021
Query: 1213 TQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEFRDFGL 1272
TQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEF+DFGL
Sbjct: 1022 TQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEFQDFGL 1081
Query: 1273 RYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAH 1332
RYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAH
Sbjct: 1082 RYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAH 1141
Query: 1333 VGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQ 1392
VGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQ
Sbjct: 1142 VGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQ 1201
Query: 1393 YKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCT 1452
YKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCT
Sbjct: 1202 YKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCT 1261
Query: 1453 VLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQESGLV 1503
VLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQESGLV
Sbjct: 1262 VLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQESGLV 1312
>gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1
[Homo sapiens]
Length = 1531
Score = 1298 bits (3358), Expect = 0.0
Identities = 687/1521 (45%), Positives = 974/1521 (64%), Gaps = 42/1521 (2%)
Query: 14 WNQTEPEPAATSLLSLCFLRTAGVWVPPMYLWVLGPIYLLFIHHHGRGYLRMSPLFKAKM 73
WN + P+ + CF T VWVP YLW P Y L++ H RGY++M+PL K K
Sbjct: 22 WNTSNPD------FTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKT 75
Query: 74 VLGFALIVLCTSSVAVALWKIQQGTPEAPEFLIHPTVWLTTMSFAVFLIHTERKKGVQSS 133
LGF L ++C + + + W+ +G AP FL+ PT+ TM A FLI ER+KGVQSS
Sbjct: 76 ALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLERRKGVQSS 135
Query: 134 GVLFGYWLL---CFVLPATNAAQQASGAGFQSDPVRHLSTYLCLSLVVAQFVLSCLADQP 190
G++ +WL+ C + + A Q D R ++ Y+ SL++ Q VLSC +D+
Sbjct: 136 GIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRS 195
Query: 191 PFFPEDPQQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVS 250
P F E NPCPE+ A+F S+ TFWW++GL+ RGYR+PL DLWSL +E++SE++V
Sbjct: 196 PLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVP 255
Query: 251 RLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAP-------ETEPFL-RQEGSQWRP-LLK 301
L K W + + R+ + + K + K E E + + +W P L K
Sbjct: 256 VLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFK 315
Query: 302 AIWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSAC 361
+++ F FL+ I D+ F+ P++L L ++F+ D K P W+GY VL+F++AC
Sbjct: 316 VLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTAC 375
Query: 362 LQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLT 421
LQTL Q + V MR+++A+ G VYRK L +++ +RK+S VG++VNL+SVD QR
Sbjct: 376 LQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFM 435
Query: 422 ESVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQM 481
+ Y+N +W + +++ LW LGPS L +AV + ++P+N ++ K +Q M
Sbjct: 436 DLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHM 495
Query: 482 RQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQV 541
+ KD+R +L + IL K +K + WE AF D+VL IR +EL L+ S L +V ++
Sbjct: 496 KSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVC 555
Query: 542 STFLVALVVFAVHTLVAEN-AMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDR 600
+ FLVAL FAV+ + EN ++A+ AFV+L + NIL LP I S+VQA VS R
Sbjct: 556 TPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKR 615
Query: 601 LVTFLCLEEVDPGVVDSSSSGSAAGKDCITIHSATFAWSQESPPCLHRINLTVPQGCLLA 660
L FL EE++P ++ G + IT+ +ATF W++ PP L+ I ++P+G L+A
Sbjct: 616 LRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVA 675
Query: 661 VVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPP 720
VVG VG GKSSLLSALL E+ KVEG V+I+G+VAYVPQ+AW+QN S+ EN+ FG +L+ P
Sbjct: 676 VVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEP 735
Query: 721 WLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPL 780
+ V++ACAL PD++ P G T IGE+G+NLSGGQKQR+SLARAVY A +YL DDPL
Sbjct: 736 YYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPL 795
Query: 781 AALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQEL 840
+A+DAHVG+H+F VIGP G+L+ TRILVTH++ LPQ D IIV++ G I+EMGSYQEL
Sbjct: 796 SAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQEL 855
Query: 841 LQRKGALVCLL------DQARQPGDRG-EGETEPGTSTKDPRG-----TSAGRRPELRRE 888
L R GA L +Q + + G G + PG K SAG+ +L+R+
Sbjct: 856 LARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGK--QLQRQ 913
Query: 889 RSIKS-----VPEKDRTTSEAQTEVPLDDPDRAGWPAGK-DSIQYGRVKATVHLAYLRAV 942
S S + +T+E Q + W + D Q G+VK +V+ Y++A+
Sbjct: 914 LSSSSSYSGDISRHHNSTAELQKA---EAKKEETWKLMEADKAQTGQVKLSVYWDYMKAI 970
Query: 943 GTPLCLYALFLFLCQQVASFCRGYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGL 1002
G + ++FLF+C V++ YWLSLW DDP V G Q +R ++G LG Q I +
Sbjct: 971 GLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAV 1030
Query: 1003 FASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDK 1062
F AV +GG ASR L LL ++RSP+SFFERTP G+L+NRFSKE DTVD IP+
Sbjct: 1031 FGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEV 1090
Query: 1063 LRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSS 1122
++ + F ++ +V+ +ATP+A + I PL L+Y Q YV SS QL+RLES S S
Sbjct: 1091 IKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSP 1150
Query: 1123 VCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGL 1182
V SH ET G +V+RAF Q F+ Q++ +VDE+Q+ +P +VA+RWLA +E +GN +
Sbjct: 1151 VYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCI 1210
Query: 1183 VFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWT 1242
V AA AV+S+ LSAGLVG SVS +LQVT L W+VR +++E +IV+VER+++Y+ T
Sbjct: 1211 VLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET 1270
Query: 1243 PKEAPWRLPTCAAQPPWPQGGQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTG 1302
KEAPW++ A WPQ G++EFR++ LRYR +L ++ ++ I+ GEKVGIVGRTG
Sbjct: 1271 EKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTG 1330
Query: 1303 AGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDL 1362
AGKSSL GL R+ E+AEG I IDG+ IA +GLH LR +I+IIPQDP+LF GSLRMNLD
Sbjct: 1331 AGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDP 1390
Query: 1363 LQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQI 1422
++SDE +W +LE LK V++LP +L ++CA+ GE+LSVGQ+QL+CLARALLRKT+I
Sbjct: 1391 FSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKI 1450
Query: 1423 LILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGS 1482
L+LDEATAAVD T+ +Q+ + + F CTVL IAHRL ++MD RV+V+DKG++ E G+
Sbjct: 1451 LVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGA 1510
Query: 1483 PAQLLAQKGLFYRLAQESGLV 1503
P+ LL Q+GLFY +A+++GLV
Sbjct: 1511 PSDLLQQRGLFYSMAKDAGLV 1531
>gi|134142340 ATP-binding cassette, sub-family C, member 1 isoform 2
[Homo sapiens]
Length = 1472
Score = 1179 bits (3049), Expect = 0.0
Identities = 651/1521 (42%), Positives = 927/1521 (60%), Gaps = 101/1521 (6%)
Query: 14 WNQTEPEPAATSLLSLCFLRTAGVWVPPMYLWVLGPIYLLFIHHHGRGYLRMSPLFKAKM 73
WN + P+ + CF T VWVP YLW P Y L++ H RGY++M+PL K K
Sbjct: 22 WNTSNPD------FTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKT 75
Query: 74 VLGFALIVLCTSSVAVALWKIQQGTPEAPEFLIHPTVWLTTMSFAVFLIHTERKKGVQSS 133
LGF L ++C + + + W+ +G AP FL+ PT+ TM A FLI ER+KGVQSS
Sbjct: 76 ALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLERRKGVQSS 135
Query: 134 GVLFGYWLL---CFVLPATNAAQQASGAGFQSDPVRHLSTYLCLSLVVAQFVLSCLADQP 190
G++ +WL+ C + + A Q D R ++ Y+ SL++ Q VLSC +D+
Sbjct: 136 GIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRS 195
Query: 191 PFFPEDPQQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVS 250
P F E NPCPE+ A+F S+ TFWW++GL+ RGYR+PL DLWSL +E++SE++V
Sbjct: 196 PLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVP 255
Query: 251 RLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAP-------ETEPFL-RQEGSQWRP-LLK 301
L K W + + R+ + + K + K E E + + +W P L K
Sbjct: 256 VLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFK 315
Query: 302 AIWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSAC 361
+++ F FL+ I D+ F+ P++L L ++F+ D K P W+GY VL+F++AC
Sbjct: 316 VLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTAC 375
Query: 362 LQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLT 421
LQTL Q + V MR+++A+ G VYRK L +++ +RK+S VG++VNL+SVD QR
Sbjct: 376 LQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFM 435
Query: 422 ESVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQM 481
+ Y+N +W + +++ LW LGPS L +AV + ++P+N ++ K +Q M
Sbjct: 436 DLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHM 495
Query: 482 RQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQV 541
+ KD+R +L + IL K +K + WE AF D+VL IR +EL L+ S L +V ++
Sbjct: 496 KSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVC 555
Query: 542 STFLVALVVFAVHTLVAEN-AMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDR 600
+ FLVAL FAV+ + EN ++A+ AFV+L + NIL LP I S+VQA VS R
Sbjct: 556 TPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKR 615
Query: 601 LVTFLCLEEVDPGVVDSSSSGSAAGKDCITIHSATFAWSQESPPCLHRINLTVPQGCLLA 660
L FL EE++P ++ G + IT+ +ATF W++ PP L+ I ++P+G L+A
Sbjct: 616 LRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVA 675
Query: 661 VVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPP 720
VVG VG GK S+LL
Sbjct: 676 VVGQVGCGK----SSLLS------------------------------------------ 689
Query: 721 WLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPL 780
AL ++D EG H +I +G+NLSGGQKQR+SLARAVY A +YL DDPL
Sbjct: 690 ---------ALLAEMDKV-EG-HVAI--KGVNLSGGQKQRVSLARAVYSNADIYLFDDPL 736
Query: 781 AALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQEL 840
+A+DAHVG+H+F VIGP G+L+ TRILVTH++ LPQ D IIV++ G I+EMGSYQEL
Sbjct: 737 SAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQEL 796
Query: 841 LQRKGALVCLL------DQARQPGDRG-EGETEPGTSTKDPRG-----TSAGRRPELRRE 888
L R GA L +Q + + G G + PG K SAG+ +L+R+
Sbjct: 797 LARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGK--QLQRQ 854
Query: 889 RSIKS-----VPEKDRTTSEAQTEVPLDDPDRAGWPAGK-DSIQYGRVKATVHLAYLRAV 942
S S + +T+E Q + W + D Q G+VK +V+ Y++A+
Sbjct: 855 LSSSSSYSGDISRHHNSTAELQKA---EAKKEETWKLMEADKAQTGQVKLSVYWDYMKAI 911
Query: 943 GTPLCLYALFLFLCQQVASFCRGYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGL 1002
G + ++FLF+C V++ YWLSLW DDP V G Q +R ++G LG Q I +
Sbjct: 912 GLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAV 971
Query: 1003 FASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDK 1062
F AV +GG ASR L LL ++RSP+SFFERTP G+L+NRFSKE DTVD IP+
Sbjct: 972 FGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEV 1031
Query: 1063 LRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSS 1122
++ + F ++ +V+ +ATP+A + I PL L+Y Q YV SS QL+RLES S S
Sbjct: 1032 IKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSP 1091
Query: 1123 VCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGL 1182
V SH ET G +V+RAF Q F+ Q++ +VDE+Q+ +P +VA+RWLA +E +GN +
Sbjct: 1092 VYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCI 1151
Query: 1183 VFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWT 1242
V AA AV+S+ LSAGLVG SVS +LQVT L W+VR +++E +IV+VER+++Y+ T
Sbjct: 1152 VLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET 1211
Query: 1243 PKEAPWRLPTCAAQPPWPQGGQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTG 1302
KEAPW++ A WPQ G++EFR++ LRYR +L ++ ++ I+ GEKVGIVGRTG
Sbjct: 1212 EKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTG 1271
Query: 1303 AGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDL 1362
AGKSSL GL R+ E+AEG I IDG+ IA +GLH LR +I+IIPQDP+LF GSLRMNLD
Sbjct: 1272 AGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDP 1331
Query: 1363 LQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQI 1422
++SDE +W +LE LK V++LP +L ++CA+ GE+LSVGQ+QL+CLARALLRKT+I
Sbjct: 1332 FSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKI 1391
Query: 1423 LILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGS 1482
L+LDEATAAVD T+ +Q+ + + F CTVL IAHRL ++MD RV+V+DKG++ E G+
Sbjct: 1392 LVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGA 1451
Query: 1483 PAQLLAQKGLFYRLAQESGLV 1503
P+ LL Q+GLFY +A+++GLV
Sbjct: 1452 PSDLLQQRGLFYSMAKDAGLV 1472
>gi|134142335 ATP-binding cassette, sub-family C, member 1 isoform 5
[Homo sapiens]
Length = 1466
Score = 1177 bits (3046), Expect = 0.0
Identities = 627/1422 (44%), Positives = 892/1422 (62%), Gaps = 42/1422 (2%)
Query: 14 WNQTEPEPAATSLLSLCFLRTAGVWVPPMYLWVLGPIYLLFIHHHGRGYLRMSPLFKAKM 73
WN + P+ + CF T VWVP YLW P Y L++ H RGY++M+PL K K
Sbjct: 22 WNTSNPD------FTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKT 75
Query: 74 VLGFALIVLCTSSVAVALWKIQQGTPEAPEFLIHPTVWLTTMSFAVFLIHTERKKGVQSS 133
LGF L ++C + + + W+ +G AP FL+ PT+ TM A FLI ER+KGVQSS
Sbjct: 76 ALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLERRKGVQSS 135
Query: 134 GVLFGYWLL---CFVLPATNAAQQASGAGFQSDPVRHLSTYLCLSLVVAQFVLSCLADQP 190
G++ +WL+ C + + A Q D R ++ Y+ SL++ Q VLSC +D+
Sbjct: 136 GIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRS 195
Query: 191 PFFPEDPQQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVS 250
P F E NPCPE+ A+F S+ TFWW++GL+ RGYR+PL DLWSL +E++SE++V
Sbjct: 196 PLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVP 255
Query: 251 RLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAP-------ETEPFL-RQEGSQWRP-LLK 301
L K W + + R+ + + K + K E E + + +W P L K
Sbjct: 256 VLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFK 315
Query: 302 AIWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSAC 361
+++ F FL+ I D+ F+ P++L L ++F+ D K P W+GY VL+F++AC
Sbjct: 316 VLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTAC 375
Query: 362 LQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLT 421
LQTL Q + V MR+++A+ G VYRK L +++ +RK+S VG++VNL+SVD QR
Sbjct: 376 LQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFM 435
Query: 422 ESVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQM 481
+ Y+N +W + +++ LW LGPS L +AV + ++P+N ++ K +Q M
Sbjct: 436 DLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHM 495
Query: 482 RQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQV 541
+ KD+R +L + IL K +K + WE AF D+VL IR +EL L+ S L +V ++
Sbjct: 496 KSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVC 555
Query: 542 STFLVALVVFAVHTLVAEN-AMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDR 600
+ FLVAL FAV+ + EN ++A+ AFV+L + NIL LP I S+VQA VS R
Sbjct: 556 TPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKR 615
Query: 601 LVTFLCLEEVDPGVVDSSSSGSAAGKDCITIHSATFAWSQESPPCLHRINLTVPQGCLLA 660
L FL EE++P ++ G + IT+ +ATF W++ PP L+ I ++P+G L+A
Sbjct: 616 LRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVA 675
Query: 661 VVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPP 720
VVG VG GKSSLLSALL E+ KVEG V+I+G+VAYVPQ+AW+QN S+ EN+ FG +L+ P
Sbjct: 676 VVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEP 735
Query: 721 WLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPL 780
+ V++ACAL PD++ P G T IGE+G+NLSGGQKQR+SLARAVY A +YL DDPL
Sbjct: 736 YYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPL 795
Query: 781 AALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQEL 840
+A+DAHVG+H+F VIGP G+L+ TRILVTH++ LPQ D IIV++ G I+EMGSYQEL
Sbjct: 796 SAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQEL 855
Query: 841 LQRKGALVCLL------DQARQPGDRG-EGETEPGTSTKDPRG-----TSAGRRPELRRE 888
L R GA L +Q + + G G + PG K SAG+ +L+R+
Sbjct: 856 LARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGK--QLQRQ 913
Query: 889 RSIKS-----VPEKDRTTSEAQTEVPLDDPDRAGWPAGK-DSIQYGRVKATVHLAYLRAV 942
S S + +T+E Q + W + D Q G+VK +V+ Y++A+
Sbjct: 914 LSSSSSYSGDISRHHNSTAELQKA---EAKKEETWKLMEADKAQTGQVKLSVYWDYMKAI 970
Query: 943 GTPLCLYALFLFLCQQVASFCRGYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGL 1002
G + ++FLF+C V++ YWLSLW DDP V G Q +R ++G LG Q I +
Sbjct: 971 GLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAV 1030
Query: 1003 FASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDK 1062
F AV +GG ASR L LL ++RSP+SFFERTP G+L+NRFSKE DTVD IP+
Sbjct: 1031 FGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEV 1090
Query: 1063 LRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSS 1122
++ + F ++ +V+ +ATP+A + I PL L+Y Q YV SS QL+RLES S S
Sbjct: 1091 IKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSP 1150
Query: 1123 VCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGL 1182
V SH ET G +V+RAF Q F+ Q++ +VDE+Q+ +P +VA+RWLA +E +GN +
Sbjct: 1151 VYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCI 1210
Query: 1183 VFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWT 1242
V AA AV+S+ LSAGLVG SVS +LQVT L W+VR +++E +IV+VER+++Y+ T
Sbjct: 1211 VLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET 1270
Query: 1243 PKEAPWRLPTCAAQPPWPQGGQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTG 1302
KEAPW++ A WPQ G++EFR++ LRYR +L ++ ++ I+ GEKVGIVGRTG
Sbjct: 1271 EKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTG 1330
Query: 1303 AGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDL 1362
AGKSSL GL R+ E+AEG I IDG+ IA +GLH LR +I+IIPQDP+LF GSLRMNLD
Sbjct: 1331 AGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDP 1390
Query: 1363 LQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSV 1404
++SDE +W +LE LK V++LP +L ++CA+ GE+L V
Sbjct: 1391 FSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLRV 1432
Score = 83.2 bits (204), Expect = 2e-15
Identities = 67/249 (26%), Positives = 113/249 (45%), Gaps = 19/249 (7%)
Query: 1251 PTCAAQPPWPQGG---QIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSS 1307
P + P GG I R+ + P + G++F I G V +VG+ G GKSS
Sbjct: 627 PDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSS 686
Query: 1308 LASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHS 1367
L S LL + EG + I G ++ +PQ + SLR N+ +
Sbjct: 687 LLSALLAEMDKVEGHVAIKG-------------SVAYVPQQAWIQNDSLRENILFGCQLE 733
Query: 1368 DEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDE 1427
+ + ++ L + LP + + ++G +LS GQKQ + LARA+ I + D+
Sbjct: 734 EPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDD 793
Query: 1428 ATAAVDPGTELQM-QAMLG--SWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPA 1484
+AVD + + ++G T +L+ H + + ++VM G+++E GS
Sbjct: 794 PLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQ 853
Query: 1485 QLLAQKGLF 1493
+LLA+ G F
Sbjct: 854 ELLARDGAF 862
Score = 49.3 bits (116), Expect = 3e-05
Identities = 20/36 (55%), Positives = 31/36 (86%)
Query: 1468 RVLVMDKGQVAESGSPAQLLAQKGLFYRLAQESGLV 1503
RV+V+DKG++ E G+P+ LL Q+GLFY +A+++GLV
Sbjct: 1431 RVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1466
>gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform 1
[Homo sapiens]
Length = 1527
Score = 1171 bits (3030), Expect = 0.0
Identities = 654/1527 (42%), Positives = 923/1527 (60%), Gaps = 45/1527 (2%)
Query: 10 GQGVWNQTEPEPAATSLLSLCFLRTAGVWVPPMYLWVLGPIYLLFIHHHGRGYLRMSPLF 69
G W+ L+ CF + WVP +YLWV P YLL++ HH RGY+ +S L
Sbjct: 11 GSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHCRGYIILSHLS 70
Query: 70 KAKMVLGFALIVLCTSSVAVALWKIQQGTPEAPEFLIHPTVWLTTMSFAVFLIHTERKKG 129
K KMVLG L + + + + + G AP F + P V TM A LI ER +G
Sbjct: 71 KLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYERLQG 130
Query: 130 VQSSGVLFGYWLLCFV---LPATNAAQQASGAGFQSDPVRHLSTYLCLSLVVAQFVLSCL 186
VQSSGVL +W LC V +P + A G SDP R + Y+ +LV++ +L+C
Sbjct: 131 VQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALILACF 190
Query: 187 ADQPPFFPEDPQQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSE 246
++PPFF NP PET A F S+ FWW + + GYR PL KDLWSL E+ S+
Sbjct: 191 REKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQ 250
Query: 247 ELVSRLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRP-LLKAIWQ 305
+V +L + W + RH KA A K SG E E L +P LKA+
Sbjct: 251 MVVQQLLEAWRKQEKQTARH-KASAAPGKNASG----EDEVLLGARPRPRKPSFLKALLA 305
Query: 306 VFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTL 365
F S+FL+ +I D+ F P+LLS+ + FI +P P+W G+L+A LMFL + +Q+L
Sbjct: 306 TFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSL 365
Query: 366 FEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVL 425
Q + + V ++ R+ I G++YRK L +++ ++AS VG++VNL+SVD QR +
Sbjct: 366 ILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAP 425
Query: 426 YLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKD 485
+LN LW + I++ +LWQ LGPS L +A + L+PLN ++ K Q +QM+ KD
Sbjct: 426 FLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKD 485
Query: 486 SRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFL 545
SR +L S IL K +K + WE +FL +V GIR EL LRT+ L + + ++ S FL
Sbjct: 486 SRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFL 545
Query: 546 VALVVFAVHTLV-AENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTF 604
V L+ V+ V N ++AEKAFV++++ NIL LP I +L QA VS R+ F
Sbjct: 546 VTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQF 605
Query: 605 LCLEEVDPGVVDSSSSGSAAGKDCITIHSATFAWSQESPPCLHRINLTVPQGCLLAVVGP 664
L EE+DP V+ + ITIHS TF W+Q+ PP LH +++ VP+G L+AVVGP
Sbjct: 606 LSQEELDPQSVERKTISPGYA---ITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGP 662
Query: 665 VGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLER 724
VG GKSSL+SALLGE+ K+EG V ++G+VAYVPQ+AW+QN ++ ENV FG+ L+P ++
Sbjct: 663 VGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQ 722
Query: 725 VLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALD 784
LEACAL D++ P G T IGE+G+NLSGGQ+QR+SLARAVY A ++LLDDPL+A+D
Sbjct: 723 TLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVD 782
Query: 785 AHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRK 844
+HV +H+F+ VIGP G+L G TR+LVTH + LPQ D+IIVLA+G ++EMG Y LLQR
Sbjct: 783 SHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRN 842
Query: 845 GALVCLLDQARQPGDRG--------------------EGETEPGTSTKDPRGTSAGRRPE 884
G+ L D+G E T D + + +
Sbjct: 843 GSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQ 902
Query: 885 LRRERSIKS---------VPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKATVH 935
R+ S S VP + SE +V + + G ++ G V+ +V
Sbjct: 903 FMRQLSALSSDGEGQGRPVPRRHLGPSE---KVQVTEAKADGALTQEEKAAIGTVELSVF 959
Query: 936 LAYLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLWADDPAVGGQQTQAALRGGIFGLLG 995
Y +AVG L L++ Q A+ WLS W +D +Q +LR G++ LG
Sbjct: 960 WDYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALG 1019
Query: 996 CLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTV 1055
LQ + + A+ GG +A+R+L Q LL + +RSP SFF+ TP G +LN FSK+ V
Sbjct: 1020 ILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVV 1079
Query: 1056 DVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRL 1115
D + + LL F + +V+ +TPL TV ILPL +LY Q Y +S QL+RL
Sbjct: 1080 DEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRL 1139
Query: 1116 ESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANV 1175
ES S S + SH +ET G++V+RA+ F ++ +VD +QR +P ++++RWL+ V
Sbjct: 1140 ESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGV 1199
Query: 1176 ELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVER 1235
E +GN +V AA AV+ ++ L+ GLVG SVS +LQVT L W++R +DLE++IV+VER
Sbjct: 1200 EFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVER 1259
Query: 1236 MQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKV 1295
+++Y+ T EAPW + WP G++EFR++ +RYRP L L ++ +S +H GEKV
Sbjct: 1260 VKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKV 1319
Query: 1296 GIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGS 1355
GIVGRTGAGKSS+ L R+ EAA+G I IDG+ +A +GLH LRS+++IIPQDPILF G+
Sbjct: 1320 GIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGT 1379
Query: 1356 LRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARA 1415
LRMNLD +S+E IW ALE L V+S P L ++C++ GE+LSVGQ+QL+CLARA
Sbjct: 1380 LRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARA 1439
Query: 1416 LLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKG 1475
LLRK++IL+LDEATAA+D T+ +QA + + F CTVL IAHRL ++MD RVLV+DKG
Sbjct: 1440 LLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKG 1499
Query: 1476 QVAESGSPAQLLAQKGLFYRLAQESGL 1502
VAE SPA L+A +G+FY +A+++GL
Sbjct: 1500 VVAEFDSPANLIAARGIFYGMARDAGL 1526
>gi|134142345 ATP-binding cassette, sub-family C, member 1 isoform 3
[Homo sapiens]
Length = 1475
Score = 1119 bits (2894), Expect = 0.0
Identities = 638/1523 (41%), Positives = 907/1523 (59%), Gaps = 102/1523 (6%)
Query: 14 WNQTEPEPAATSLLSLCFLRTAGVWVPPMYLWVLGPIYLLFIHHHGRGYLRMSPLFKAKM 73
WN + P+ + CF T VWVP YLW P Y L++ H RGY++M+PL K K
Sbjct: 22 WNTSNPD------FTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKT 75
Query: 74 VLGFALIVLCTSSVAVALWKIQQGTPEAPEFLIHPTVWLTTMSFAVFLIHTERKKGVQSS 133
LGF L ++C + + + W+ +G AP FL+ PT+ TM A FLI ER+KGVQSS
Sbjct: 76 ALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLERRKGVQSS 135
Query: 134 GVLFGYWLL---CFVLPATNAAQQASGAGFQSDPVRHLSTYLCLSLVVAQFVLSCLADQP 190
G++ +WL+ C + + A Q D R ++ Y+ SL++ Q VLSC +D+
Sbjct: 136 GIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRS 195
Query: 191 PFFPEDPQQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVS 250
P F E NPCPE+ A+F S+ TFWW++GL+ RGYR+PL DLWSL +E++SE++V
Sbjct: 196 PLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVP 255
Query: 251 RLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAP-------ETEPFL-RQEGSQWRP-LLK 301
L K W + + R+ + + K + K E E + + +W P L K
Sbjct: 256 VLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFK 315
Query: 302 AIWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSAC 361
+++ F FL+ I D+ F+ P++L L ++F+ D K P W+GY VL+F++AC
Sbjct: 316 VLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTAC 375
Query: 362 LQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLT 421
LQTL Q + V MR+++A+ G VYRK L +++ +RK+S VG++VNL+SVD QR
Sbjct: 376 LQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFM 435
Query: 422 ESVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQM 481
+ Y+N +W + +++ LW LGPS L +AV + ++P+N ++ K +Q M
Sbjct: 436 DLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHM 495
Query: 482 RQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQV 541
+ KD+R +L + IL K +K + WE AF D+VL IR +EL L+ S L +V ++
Sbjct: 496 KSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVC 555
Query: 542 STFLVALVVFAVHTLVAEN-AMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDR 600
+ FLVAL FAV+ + EN ++A+ AFV+L + NIL LP I S+VQA VS R
Sbjct: 556 TPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKR 615
Query: 601 LVTFLCLEEVDPGVVDSSSSGSAAGKDCITIHSATFAWSQESPPCLHRINLTVPQGCLLA 660
L FL EE++P ++ G + IT+ +ATF W++ PP L+ I ++P+G L+A
Sbjct: 616 LRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVA 675
Query: 661 VVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPP 720
VVG VG GKSSLLSALL E+ KVE G VA A+V +
Sbjct: 676 VVGQVGCGKSSLLSALLAEMDKVE------GHVAIKGSVAYVPQQA-------------- 715
Query: 721 WLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKA--AVYLLDD 778
W++ DS E I L G Q L YR A LL D
Sbjct: 716 WIQN-----------DSLRENI----------LFGCQ-----LEEPYYRSVIQACALLPD 749
Query: 779 PLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQ 838
L L + G + TRILVTH++ LPQ D IIV++ G I+EMGSYQ
Sbjct: 750 -LEILPS-----------GDRTEIGEKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQ 797
Query: 839 ELLQRKGALVCLL------DQARQPGDRG-EGETEPGTSTKDPRG-----TSAGRRPELR 886
ELL R GA L +Q + + G G + PG K SAG+ +L+
Sbjct: 798 ELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGK--QLQ 855
Query: 887 RERSIKS-----VPEKDRTTSEAQTEVPLDDPDRAGWPAGK-DSIQYGRVKATVHLAYLR 940
R+ S S + +T+E Q + W + D Q G+VK +V+ Y++
Sbjct: 856 RQLSSSSSYSGDISRHHNSTAELQKA---EAKKEETWKLMEADKAQTGQVKLSVYWDYMK 912
Query: 941 AVGTPLCLYALFLFLCQQVASFCRGYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAI 1000
A+G + ++FLF+C V++ YWLSLW DDP V G Q +R ++G LG Q I
Sbjct: 913 AIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGI 972
Query: 1001 GLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIP 1060
+F AV +GG ASR L LL ++RSP+SFFERTP G+L+NRFSKE DTVD IP
Sbjct: 973 AVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIP 1032
Query: 1061 DKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASY 1120
+ ++ + F ++ +V+ +ATP+A + I PL L+Y Q YV SS QL+RLES S
Sbjct: 1033 EVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSR 1092
Query: 1121 SSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGN 1180
S V SH ET G +V+RAF Q F+ Q++ +VDE+Q+ +P +VA+RWLA +E +GN
Sbjct: 1093 SPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGN 1152
Query: 1181 GLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYA 1240
+V AA AV+S+ LSAGLVG SVS +LQVT L W+VR +++E +IV+VER+++Y+
Sbjct: 1153 CIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYS 1212
Query: 1241 WTPKEAPWRLPTCAAQPPWPQGGQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGR 1300
T KEAPW++ A WPQ G++EFR++ LRYR +L ++ ++ I+ GEKVGIVGR
Sbjct: 1213 ETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGR 1272
Query: 1301 TGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNL 1360
TGAGKSSL GL R+ E+AEG I IDG+ IA +GLH LR +I+IIPQDP+LF GSLRMNL
Sbjct: 1273 TGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNL 1332
Query: 1361 DLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKT 1420
D ++SDE +W +LE LK V++LP +L ++CA+ GE+LSVGQ+QL+CLARALLRKT
Sbjct: 1333 DPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKT 1392
Query: 1421 QILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAES 1480
+IL+LDEATAAVD T+ +Q+ + + F CTVL IAHRL ++MD RV+V+DKG++ E
Sbjct: 1393 KILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEY 1452
Query: 1481 GSPAQLLAQKGLFYRLAQESGLV 1503
G+P+ LL Q+GLFY +A+++GLV
Sbjct: 1453 GAPSDLLQQRGLFYSMAKDAGLV 1475
>gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
[Homo sapiens]
Length = 1545
Score = 999 bits (2584), Expect = 0.0
Identities = 585/1533 (38%), Positives = 879/1533 (57%), Gaps = 75/1533 (4%)
Query: 27 LSLCFLRTAGVWVPPMYLWVLGPIYLLFIHHHGRGYLRMSPLFKAKMV-LGFALIVLCTS 85
L LCF +T VW+P +LW+L P LL ++ + L+ AK V +GF LI+
Sbjct: 23 LPLCFEQTVLVWIPLGFLWLLAPWQLLHVYKSRTKRSSTTKLYLAKQVFVGFLLILAAIE 82
Query: 86 SVAVALWKIQQGTPEAPEFLIHPTVWLTTMSFAVFLIHTERKKGVQSSGVLFGYWLLCFV 145
V Q T A + +P+++L T V LI R+ VQ + + + +
Sbjct: 83 LALVLTEDSGQATVPAVRYT-NPSLYLGTW-LLVLLIQYSRQWCVQKNSWFLSLFWILSI 140
Query: 146 LPATNAAQQASGAGFQSDPVRHLSTYLCLSLVVAQFVLSCLADQPPFFPEDPQQSNPCPE 205
L T Q Q D Y CL + F + L F E+ + SN P
Sbjct: 141 LCGTFQFQTLIRTLLQGDNSN--LAYSCLFFISYGFQILILIFSA--FSENNESSNN-PS 195
Query: 206 TGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRSAARR 265
+ A+F S T+ W ++ +GY+RPL +D+W + E ++ LVS+ E R ARR
Sbjct: 196 SIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLVSKFETHMKRELQKARR 255
Query: 266 HNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRP------------------------LLK 301
A+ +++ S + P L + SQ + L+K
Sbjct: 256 ---ALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKKDVPKSWLMK 312
Query: 302 AIWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSAC 361
A+++ F+ L L +++D+F F P+LL L + F D W GYL A+L+F +A
Sbjct: 313 ALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDTYLWIGYLCAILLFTAAL 372
Query: 362 LQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLT 421
+Q+ Q L +++R+AI VY+K L LS+ +RK VG+ VNL+SVD Q+L
Sbjct: 373 IQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQKLM 432
Query: 422 ESVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQM 481
+ +++ LW ++ IV+ +LW+ LGPS L + V + ++P+N +S K Q + M
Sbjct: 433 DVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKNM 492
Query: 482 RQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQV 541
+ KD R ++ + IL K +K+ WE +F D+V +R +EL L L V + FQ+
Sbjct: 493 KNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVFQL 552
Query: 542 STFLVALVVFAVHTLV-AENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDR 600
+ LV++V F+V+ LV + N ++A+KAF ++T+ NIL + LP I S++QA VS +R
Sbjct: 553 TPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMMISSMLQASVSTER 612
Query: 601 LVTFLCLEEVDPGVVDSSSSGSAAGKDCITIHSATFAWSQESPPCLHRINLTVPQGCLLA 660
L +L +++D + + A + A+F W +S + +NL + G L+A
Sbjct: 613 LEKYLGGDDLDTSAIRHDCNFDKA----MQFSEASFTWEHDSEATVRDVNLDIMAGQLVA 668
Query: 661 VVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPP 720
V+GPVG+GKSSL+SA+LGE+ V G ++I+G AYVPQ++W+QN ++ +N+ FG E +
Sbjct: 669 VIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNILFGTEFNEK 728
Query: 721 WLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPL 780
++VLEACAL PD++ P G IGE+G+NLSGGQKQR+SLARA Y+ +YLLDDPL
Sbjct: 729 RYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPL 788
Query: 781 AALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQEL 840
+A+DAHVG+H+FN+V+GP GLL+G TR+LVTH++H LPQ D I+VL NG I E GSY L
Sbjct: 789 SAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSAL 848
Query: 841 LQRKGALVCLLDQ-ARQPGDRGEGETEPGTSTKDP--------------------RGTSA 879
L +KG L R G E G+ +D R ++
Sbjct: 849 LAKKGEFAKNLKTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAASITMRRENS 908
Query: 880 GRRPELRRERS----IKSVPE--KDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKAT 933
RR R RS +KS+ K R + + + L + K+ I+ G+VK +
Sbjct: 909 FRRTLSRSSRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQKL---IKKEFIETGKVKFS 965
Query: 934 VHLAYLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLWADDPAVGGQ----QTQAALRGG 989
++L YL+A+G + + F+ VA WLS W D + +Q +R G
Sbjct: 966 IYLEYLQAIGLFSIFFIILAFVMNSVAFIGSNLWLSAWTSDSKIFNSTDYPASQRDMRVG 1025
Query: 990 IFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFS 1049
++G LG Q I +F + G AS +L ++LL +++R+P+ FF+ TP G ++NRF+
Sbjct: 1026 VYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFA 1085
Query: 1050 KETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSS 1109
+ TVD +P LRS + G++ +++ +ATP+ T+ ++PL ++Y Q YV +S
Sbjct: 1086 GDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTS 1145
Query: 1110 CQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADR 1169
QLRRL+S + S + SH +ET G V+RAF Q F+ N R+D +Q+ F + ++R
Sbjct: 1146 RQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNR 1205
Query: 1170 WLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENS 1229
WLA +EL+GN VF +A V+ + LS VGF +S AL +TQTL W+VR +++E +
Sbjct: 1206 WLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMTSEIETN 1265
Query: 1230 IVSVERMQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEFRDFGLRYRPELPLAVQGVSFKI 1289
IV+VER+ +Y EAPW + P WP G+I+F ++ +RYRPEL L ++G++ I
Sbjct: 1266 IVAVERITEYTKVENEAPW-VTDKRPPPDWPSKGKIQFNNYQVRYRPELDLVLRGITCDI 1324
Query: 1290 HAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDP 1349
+ EK+G+VGRTGAGKSSL + L R+ EAA G I IDGV IA +GLH LR +++IIPQDP
Sbjct: 1325 GSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDP 1384
Query: 1350 ILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQL 1409
ILF GSLRMNLD +SDE IW ALE LK+ VASL L ++ + G +LS+GQ+QL
Sbjct: 1385 ILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQL 1444
Query: 1410 LCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARV 1469
LCL RALLRK++IL+LDEATAAVD T+ +Q + + FA CTV+ IAHRL ++MD +V
Sbjct: 1445 LCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKV 1504
Query: 1470 LVMDKGQVAESGSPAQLLAQKGLFYRLAQESGL 1502
+V+D G++ E GSP +LL G FY +A+E+G+
Sbjct: 1505 MVLDNGKIIECGSPEELLQIPGPFYFMAKEAGI 1537
>gi|157502201 ATP-binding cassette, sub-family C, member 4 isoform 1
[Homo sapiens]
Length = 1325
Score = 674 bits (1739), Expect = 0.0
Identities = 442/1331 (33%), Positives = 697/1331 (52%), Gaps = 86/1331 (6%)
Query: 198 QQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWM 257
Q+ P P A S+ FWW++ L G++R L D++S+ E+ S+ L L+ W
Sbjct: 6 QEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFW- 64
Query: 258 RNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLS 317
++ R N A Q+ S R ++K W+ S +LG +
Sbjct: 65 -DKEVLRAENDA---------------------QKPSLTRAIIKCYWK---SYLVLGIFT 99
Query: 318 LI------ISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNM 371
LI I +F + K+++ F + Y A ++ + +
Sbjct: 100 LIEESAKVIQPIF---LGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYF 156
Query: 372 YRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLW 431
Y ++ MRLR A+ ++YRK L LS+ + + G +VNL+S DV + + ++L+ LW
Sbjct: 157 YHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLW 216
Query: 432 LPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLT 491
+ + LW +G S L +AV + LLPL K + + + D+R R
Sbjct: 217 AGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTM 276
Query: 492 SSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVF 551
+ ++ + IK + WE +F + + +R +E+ + S L ++L SF ++ ++ V F
Sbjct: 277 NEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTF 336
Query: 552 AVHTLVAENAMNAEKAFVTLTVLNILN-KAQAFLPFSIHSLVQARVSFDRLVTFLCLEEV 610
+ L+ + + A + FV +T+ + F P +I + +A VS R+ TFL L+E+
Sbjct: 337 TTYVLLG-SVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEI 395
Query: 611 DPGVVDSSSSGSAAGKDCITIHSATFAWSQESP-PCLHRINLTVPQGCLLAVVGPVGAGK 669
+ + GK + + T W + S P L ++ TV G LLAVVGPVGAGK
Sbjct: 396 S----QRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGK 451
Query: 670 SSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEAC 729
SSLLSA+LGEL+ G VS+ G +AYV Q+ WV + ++ N+ FG++ + E+V++AC
Sbjct: 452 SSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKAC 511
Query: 730 ALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQ 789
AL+ D+ +G T IG++G LSGGQK R++LARAVY+ A +YLLDDPL+A+DA V +
Sbjct: 512 ALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSR 571
Query: 790 HVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVC 849
H+F I +L ILVTH L L A I++L +G + + G+Y E L+
Sbjct: 572 HLFELCICQ--ILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGS 629
Query: 850 LLDQARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVP 909
LL ++ + E PGT P LR +S +++ + +
Sbjct: 630 LL---KKDNEESEQPPVPGT-------------PTLRNRTFSESSVWSQQSSRPSLKDGA 673
Query: 910 LDDPDRAGWPA--GKDSIQYGRVKATVHLAYLRAVGTPLC-LYALFLFLCQQVASFCRGY 966
L+ D P +++ G+V + Y RA + ++ + L QVA + +
Sbjct: 674 LESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDW 733
Query: 967 WLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASM--AAVLLGGARA-------- 1016
WLS WA+ ++ G + L +G+++ + A VL G AR+
Sbjct: 734 WLSYWANKQSMLNVTVNGG--GNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLV 791
Query: 1017 --SRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLL 1074
S+ L ++ ++++P+ FF+R PIG +LNRFSK+ +D +P + L + LL
Sbjct: 792 NSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLP---LTFLDFIQTLL 848
Query: 1075 EVSLVVAVAT---PLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETF 1131
+V VV+VA P + ++PL +++ + ++ +S ++RLES + S V SH++ +
Sbjct: 849 QVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSL 908
Query: 1132 QGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAV 1191
QG +RA++ + +A D F L RW A ++ + V A ++
Sbjct: 909 QGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSL 968
Query: 1192 LSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLP 1251
+ L AG VG ++S AL + QW VR ++EN ++SVER+ +Y KEAPW
Sbjct: 969 ILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQ 1028
Query: 1252 TCAAQPPWPQGGQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASG 1311
P WP G I F + Y P PL ++ ++ I + EKVGIVGRTGAGKSSL S
Sbjct: 1029 K-RPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISA 1087
Query: 1312 LLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAI 1371
L RL E EG IWID + +GLH LR ++SIIPQ+P+LF G++R NLD EH+DE +
Sbjct: 1088 LFRLSEP-EGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEEL 1146
Query: 1372 WAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAA 1431
W AL+ VQLK + LPG++ + A+ G + SVGQ+QL+CLARA+LRK QILI+DEATA
Sbjct: 1147 WNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATAN 1206
Query: 1432 VDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQK- 1490
VDP T+ +Q + FA CTVL IAHRL +++D +++V+D G++ E P LL K
Sbjct: 1207 VDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKE 1266
Query: 1491 GLFYRLAQESG 1501
LFY++ Q+ G
Sbjct: 1267 SLFYKMVQQLG 1277
>gi|134142342 ATP-binding cassette, sub-family C, member 1 isoform 4
[Homo sapiens]
Length = 1416
Score = 637 bits (1642), Expect = 0.0
Identities = 345/716 (48%), Positives = 477/716 (66%), Gaps = 23/716 (3%)
Query: 806 TRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLL------DQARQPGD 859
TRILVTH++ LPQ D IIV++ G I+EMGSYQELL R GA L +Q + +
Sbjct: 706 TRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEE 765
Query: 860 RG-EGETEPGTSTKDPRG-----TSAGRRPELRRERSIKS-----VPEKDRTTSEAQTEV 908
G G + PG K SAG+ +L+R+ S S + +T+E Q
Sbjct: 766 NGVTGVSGPGKEAKQMENGMLVTDSAGK--QLQRQLSSSSSYSGDISRHHNSTAELQKA- 822
Query: 909 PLDDPDRAGWPAGK-DSIQYGRVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCRGYW 967
+ W + D Q G+VK +V+ Y++A+G + ++FLF+C V++ YW
Sbjct: 823 --EAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYW 880
Query: 968 LSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWD 1027
LSLW DDP V G Q +R ++G LG Q I +F AV +GG ASR L LL
Sbjct: 881 LSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHS 940
Query: 1028 VVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLA 1087
++RSP+SFFERTP G+L+NRFSKE DTVD IP+ ++ + F ++ +V+ +ATP+A
Sbjct: 941 ILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIA 1000
Query: 1088 TVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFV 1147
+ I PL L+Y Q YV SS QL+RLES S S V SH ET G +V+RAF Q F+
Sbjct: 1001 AIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFI 1060
Query: 1148 AQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVS 1207
Q++ +VDE+Q+ +P +VA+RWLA +E +GN +V AA AV+S+ LSAGLVG SVS
Sbjct: 1061 HQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVS 1120
Query: 1208 AALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEF 1267
+LQVT L W+VR +++E +IV+VER+++Y+ T KEAPW++ A WPQ G++EF
Sbjct: 1121 YSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEF 1180
Query: 1268 RDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDG 1327
R++ LRYR +L ++ ++ I+ GEKVGIVGRTGAGKSSL GL R+ E+AEG I IDG
Sbjct: 1181 RNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDG 1240
Query: 1328 VPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASL 1387
+ IA +GLH LR +I+IIPQDP+LF GSLRMNLD ++SDE +W +LE LK V++L
Sbjct: 1241 INIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSAL 1300
Query: 1388 PGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSW 1447
P +L ++CA+ GE+LSVGQ+QL+CLARALLRKT+IL+LDEATAAVD T+ +Q+ + +
Sbjct: 1301 PDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQ 1360
Query: 1448 FAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQESGLV 1503
F CTVL IAHRL ++MD RV+V+DKG++ E G+P+ LL Q+GLFY +A+++GLV
Sbjct: 1361 FEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1416
Score = 518 bits (1335), Expect = e-146
Identities = 276/704 (39%), Positives = 413/704 (58%), Gaps = 25/704 (3%)
Query: 14 WNQTEPEPAATSLLSLCFLRTAGVWVPPMYLWVLGPIYLLFIHHHGRGYLRMSPLFKAKM 73
WN + P+ + CF T VWVP YLW P Y L++ H RGY++M+PL K K
Sbjct: 22 WNTSNPD------FTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKT 75
Query: 74 VLGFALIVLCTSSVAVALWKIQQGTPEAPEFLIHPTVWLTTMSFAVFLIHTERKKGVQSS 133
LGF L ++C + + + W+ +G AP FL+ PT+ TM A FLI ER+KGVQSS
Sbjct: 76 ALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLERRKGVQSS 135
Query: 134 GVLFGYWLL---CFVLPATNAAQQASGAGFQSDPVRHLSTYLCLSLVVAQFVLSCLADQP 190
G++ +WL+ C + + A Q D R ++ Y+ SL++ Q VLSC +D+
Sbjct: 136 GIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRS 195
Query: 191 PFFPEDPQQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVS 250
P F E NPCPE+ A+F S+ TFWW++GL+ RGYR+PL DLWSL +E++SE++V
Sbjct: 196 PLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVP 255
Query: 251 RLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAP-------ETEPFL-RQEGSQWRP-LLK 301
L K W + + R+ + + K + K E E + + +W P L K
Sbjct: 256 VLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFK 315
Query: 302 AIWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSAC 361
+++ F FL+ I D+ F+ P++L L ++F+ D K P W+GY VL+F++AC
Sbjct: 316 VLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTAC 375
Query: 362 LQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLT 421
LQTL Q + V MR+++A+ G VYRK L +++ +RK+S VG++VNL+SVD QR
Sbjct: 376 LQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFM 435
Query: 422 ESVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQM 481
+ Y+N +W + +++ LW LGPS L +AV + ++P+N ++ K +Q M
Sbjct: 436 DLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHM 495
Query: 482 RQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQV 541
+ KD+R +L + IL K +K + WE AF D+VL IR +EL L+ S L +V ++
Sbjct: 496 KSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVC 555
Query: 542 STFLVALVVFAVHTLVAE-NAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDR 600
+ FLVAL FAV+ + E N ++A+ AFV+L + NIL LP I S+VQA VS R
Sbjct: 556 TPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKR 615
Query: 601 LVTFLCLEEVDPGVVDSSSSGSAAGKDCITIHSATFAWSQESPPCLHRINLTVPQGCLLA 660
L FL EE++P ++ G + IT+ +ATF W++ PP L+ I ++P+G L+A
Sbjct: 616 LRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVA 675
Query: 661 VVGPVGAGKSSLLSALLGELSKVEGFVSIE------GAVAYVPQ 698
VVG VG GKSSLLSALL E+ KVEG V+I+ +++Y+PQ
Sbjct: 676 VVGQVGCGKSSLLSALLAEMDKVEGHVAIKTRILVTHSMSYLPQ 719
Score = 82.0 bits (201), Expect = 4e-15
Identities = 62/222 (27%), Positives = 102/222 (45%), Gaps = 16/222 (7%)
Query: 646 LHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGA------------- 692
L IN+T+ G + +VG GAGKSSL L EG + I+G
Sbjct: 1195 LRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFK 1254
Query: 693 VAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMN 752
+ +PQ+ + + S+ N+ + + LE L+ V + P+ + E G N
Sbjct: 1255 ITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGEN 1314
Query: 753 LSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTH 812
LS GQ+Q + LARA+ RK + +LD+ AA+D + + + + T + + H
Sbjct: 1315 LSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTI---RTQFEDCTVLTIAH 1371
Query: 813 ALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQA 854
L+ + +IVL G I E G+ +LLQ++G + A
Sbjct: 1372 RLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDA 1413
Score = 40.8 bits (94), Expect = 0.010
Identities = 26/78 (33%), Positives = 36/78 (46%), Gaps = 3/78 (3%)
Query: 1251 PTCAAQPPWPQGG---QIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSS 1307
P + P GG I R+ + P + G++F I G V +VG+ G GKSS
Sbjct: 627 PDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSS 686
Query: 1308 LASGLLRLQEAAEGGIWI 1325
L S LL + EG + I
Sbjct: 687 LLSALLAEMDKVEGHVAI 704
>gi|110832839 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A-delta-14 [Homo sapiens]
Length = 1513
Score = 611 bits (1576), Expect = e-174
Identities = 457/1491 (30%), Positives = 727/1491 (48%), Gaps = 110/1491 (7%)
Query: 67 PLFKAKMVLGFALIVLCTSSVAVALWKIQQGTPEAPEF-LIHPTV--WLTTMSFAVFLIH 123
P + +L FAL+ + +A + + E+ L P V ++ T + V+ +
Sbjct: 67 PGHNLRWILTFALLFVHVCEIAEGI--VSDSRRESRHLHLFMPAVMGFVATTTSIVYYHN 124
Query: 124 TERKKGVQSSGVLFGYWLLCFVLPATNAAQQASGAGFQSDPVRHLSTYLCLSL--VVAQF 181
E + LF YW++ F+ + +G +R T + + L ++
Sbjct: 125 IETSNFPKLLLALFLYWVMAFITKTIKLVKYCQ-SGLDISNLRFCITGMMVILNGLLMAV 183
Query: 182 VLSCLADQPPFFPEDPQQSNP---CPETGAAFP-------SKATFWWVSGLVWRGYRRPL 231
++ + + F +PQ+ P + G F SKAT+WW++ L+ +++P+
Sbjct: 184 EINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPI 243
Query: 232 RPKDLWSLGRENSSEELVSRLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQ 291
DL ++G+ + R ++ + A K +A P P
Sbjct: 244 ---DLKAIGKL----PIAMRAVTNYVCLKDAYEEQKKKVA---------DHPNRTP---- 283
Query: 292 EGSQWRPLLKAIWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDP--------- 342
S W A+++ F LL + ++D+ F P +S ++ + +
Sbjct: 284 --SIWL----AMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTG 337
Query: 343 -------KPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLA 395
K Y+LAVL+FL+ LQ F Q + Y + LR A+ ++Y K+L
Sbjct: 338 ISETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILR 397
Query: 396 LSSG--SRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFVYLWQLLGPSAL 453
LS+ S +G + NLV+++ +L + LW V I++ + L+ LLG SAL
Sbjct: 398 LSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSAL 457
Query: 454 TAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFHGWEGAFLDR 513
AV + L P+ +FI+ K Q+ + R + T+ IL+ K +K + WE F
Sbjct: 458 VGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKS 517
Query: 514 VLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAMNAEKAFVTLTV 573
V R +EL +L+T L S+S+ L F H + N + +AF +L++
Sbjct: 518 VEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSL 577
Query: 574 LNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDPG---VVDSSSSGSAAGKDCIT 630
+IL L + V+A +S +L FL +E+ +SS + K
Sbjct: 578 FHILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGV 637
Query: 631 IHSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFV--- 687
+ + F+W L I++ +P G L +VG VG GKSSLL A+LGE+ +EG V
Sbjct: 638 VTNGYFSWGS-GLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWS 696
Query: 688 -------SIEG-------AVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQP 733
S E +VAY Q+ W+ N +V EN+ FG + + V +AC+LQP
Sbjct: 697 NVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQP 756
Query: 734 DVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFN 793
D+D P G T IGE+G+NLSGGQ+QR+ +ARA+Y+ + LDDP +ALD H+ H+
Sbjct: 757 DIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQ 816
Query: 794 QVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQ 853
+ I T +LVTH L L ADWII + +G++ G+ +++ + V L +
Sbjct: 817 EGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKD---VELYEH 873
Query: 854 ARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDDP 913
+ +R + E E T+ R+ R S ++ + + E + E DD
Sbjct: 874 WKTLMNRQDQELEKDMEADQ---TTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDD- 929
Query: 914 DRAGWPAGKDSIQYGRVKATVHLA--YLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLW 971
++ R K YL + G L + +F L + YWL+ W
Sbjct: 930 -------NMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATW 982
Query: 972 ADDPAVG--GQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVV 1029
+ ++ G+ Q G L G + L S+ +G A++ L LL ++
Sbjct: 983 TSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMG-LTAAKNLHHNLLNKII 1041
Query: 1030 RSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATV 1089
PI FF+ TP+G +LNRFS +T+ +D IP L SL L +++ ATP+ V
Sbjct: 1042 LGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLV 1101
Query: 1090 AILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQ 1149
A+LPL + + Q + V+S L+ L+ ++ + H +ET +G T +RAFR + F Q
Sbjct: 1102 ALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRF-KQ 1160
Query: 1150 NNARVDESQRISFPRL-VADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSA 1208
+ ++ I++ L A+RWL + LG +V A+ ++ ++ +GLVG +
Sbjct: 1161 RMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSN--SGLVGLGLLY 1218
Query: 1209 ALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPP--WPQGGQIE 1266
AL +T L WVVRN DLE + +V+++ + T + + +Q P WPQ G+I+
Sbjct: 1219 ALTITNYLNWVVRNLADLEVQMGAVKKVNSFL-TMESENYEGTMDPSQVPEHWPQEGEIK 1277
Query: 1267 FRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWID 1326
D +RY L ++ V I G+KVGI GRTG+GKSSL+ R+ + +G I ID
Sbjct: 1278 IHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVID 1337
Query: 1327 GVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVAS 1386
G+ I+ + LHTLRSR+SII QDPILF GS+R NLD + +D+ +W ALE QLK +V S
Sbjct: 1338 GIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKS 1397
Query: 1387 LPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGS 1446
LPG L + GE+ SVGQ+QL CLARA +RK+ ILI+DEATA++D TE +Q ++ +
Sbjct: 1398 LPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMT 1457
Query: 1447 WFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQK-GLFYRL 1496
FA TV+ IAHR+ S+MD VLV +G + E + LLA K GLF L
Sbjct: 1458 AFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTL 1508
>gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo
sapiens]
Length = 1581
Score = 608 bits (1567), Expect = e-173
Identities = 465/1596 (29%), Positives = 745/1596 (46%), Gaps = 187/1596 (11%)
Query: 30 CFLRTAGVWVPPMYLWVLGPIYLLF-------IHHHGRGYLRMSPLFKAKMVLGFALIVL 82
CF+ V L++ PI + +H H +L P + +L F L+ +
Sbjct: 26 CFVDALNVVPHVFLLFITFPILFIGWGSQSSKVHIHHSTWLHF-PGHNLRWILTFMLLFV 84
Query: 83 CTSSVAVALWKIQQGTPEAPEFLIHPTV---WLTTMSFAVFLIHTERKKGVQSSGVLFGY 139
+A + + G E+ ++ ++ ++ V+ + E + L Y
Sbjct: 85 LVCEIAEGI--LSDGVTESHHLHLYMPAGMAFMAAVTSVVYYHNIETSNFPKLLIALLVY 142
Query: 140 WLLCFVLPATNAAQQASGA-GFQSDPVRHLSTYLCLSL--VVAQFVLSCLADQPPFFPED 196
W L F+ + A GF +R T L + L ++ ++ + + F +
Sbjct: 143 WTLAFITKTIKFVKFLDHAIGFSQ--LRFCLTGLLVILYGMLLLVEVNVIRVRRYIFFKT 200
Query: 197 PQQSNP---CPETGAAFP-------SKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSE 246
P++ P + G F SK T+WW++ + +++P+ DL ++G+ +
Sbjct: 201 PREVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPI---DLRAIGKLPIAM 257
Query: 247 ELVSRLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQV 306
++ ++ + + +G G +A + +A+
Sbjct: 258 RALTNYQR-------LCEAFDAQVRKDIQGTQGARA----------------IWQALSHA 294
Query: 307 FHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIG------DPKPPAW------------K 348
F +L + I++D+ F P + ++ +G PK
Sbjct: 295 FGRRLVLSSTFRILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFLGVYFVSSQEFLAN 354
Query: 349 GYLLAVLMFLSACLQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSG--SRKASAV 406
Y+LAVL+FL+ LQ F Q + Y + LR AI +Y K++ LS+ S
Sbjct: 355 AYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTA 414
Query: 407 GDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLN 466
G + NLV++D +L LW V I+V + L+ +LG SAL AV + L P+
Sbjct: 415 GQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQ 474
Query: 467 FFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALR 526
+F++ K + Q + + R + T+ +LR K +K + WE F RV R +E+ +LR
Sbjct: 475 YFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLR 534
Query: 527 TSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENA-MNAEKAFVTLTVLNILNKAQAFLP 585
+ S+S+ L+ F H + A + AF +L++ +IL L
Sbjct: 535 AFAIYTSISIFMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLSLFHILVTPLFLLS 594
Query: 586 FSIHSLVQARVSFDRLVTFLCLEEV--------DP------------------------- 612
+ S V+A VS +L FL E+ +P
Sbjct: 595 SVVRSTVKALVSVQKLSEFLSSAEIREEQCAPHEPTPQGPASKYQAVPLRVVNRKRPARE 654
Query: 613 ------GVVDS--SSSGSAAGKDCITIHSATFAWSQESPPCLHRINLTVPQGCLLAVVGP 664
G + S S+ A C+ I F W+ + P L I + +P+G L +VG
Sbjct: 655 DCRGLTGPLQSLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQ 714
Query: 665 VGAGKSSLLSALLGELSKVEGFV--------------------------SIEGAVAYVPQ 698
VG GKSSLL A LGE+ KV G V G VAY Q
Sbjct: 715 VGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQ 774
Query: 699 EAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQK 758
+ W+ N +V EN+ F + + V+EAC+LQPD+D P G T IGE+G+NLSGGQ+
Sbjct: 775 KPWLLNATVEENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQR 834
Query: 759 QRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTR--ILVTHALHI 816
QR+S+ARA+Y+ A V LDDP +ALD H+ H+ G LL+ R +LVTH L
Sbjct: 835 QRISVARALYQHANVVFLDDPFSALDIHLSDHLMQA--GILELLRDDKRTVVLVTHKLQY 892
Query: 817 LPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQARQPGDRGEGETEPGT-----ST 871
LP ADWII + +G I G+ ++ + + L + + +R + E E T +T
Sbjct: 893 LPHADWIIAMKDGTIQREGTLKDFQRSECQL---FEHWKTLMNRQDQELEKETVTERKAT 949
Query: 872 KDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRVK 931
+ P+G S R R+ ++ E++ +E++ + L Q +
Sbjct: 950 EPPQGLS---RAMSSRDGLLQDEEEEEEEAAESEEDDNLSSMLH----------QRAEIP 996
Query: 932 ATVHLAYLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLWADD-----PAVGG------- 979
YL + G L +F L + + YWL+ W D PA
Sbjct: 997 WRACAKYLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSALTLTPAARNCSLSQEC 1056
Query: 980 --QQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFE 1037
QT A+ +F +L L + + V G + ++ L + LL ++ +P+ FFE
Sbjct: 1057 TLDQTVYAM---VFTVLCSLGIVLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFE 1113
Query: 1038 RTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLL 1097
TP+G +LNRFS + +T+D IP L L + V++ TP+ VA+LPL ++
Sbjct: 1114 TTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVISYVTPVFLVALLPLAIV 1173
Query: 1098 YAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDES 1157
Q + V+S L++L+ + + SH AET +G T +RAFR +A F + D +
Sbjct: 1174 CYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSN 1233
Query: 1158 QRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAH--LSAGLVGFSVSAALQVTQT 1215
S A+RWL +E +G +V AA ++ + H LSAGLVG ++ AL V+
Sbjct: 1234 NIASLFLTAANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYALMVSNY 1293
Query: 1216 LQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPP-WPQGGQIEFRDFGLRY 1274
L W+VRN D+E + +V+R+ T E+ L + P WP G+I+ ++ +RY
Sbjct: 1294 LNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRY 1353
Query: 1275 RPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVG 1334
L ++ V+ I G+K+GI GRTG+GKSS + R+ + EG I IDG+ IA +
Sbjct: 1354 DSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLP 1413
Query: 1335 LHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYK 1394
LHTLRSR+SII QDP+LF G++R NLD ++ SD +W ALE QLK +V +LPG L
Sbjct: 1414 LHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVVKALPGGLDAI 1473
Query: 1395 CADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVL 1454
+ GE+ S GQ+QL CLARA +RKT I I+DEATA++D TE +Q ++ + FA TV+
Sbjct: 1474 ITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVV 1533
Query: 1455 LIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQK 1490
IAHR+ +++ V+V+ +G + E P +LL++K
Sbjct: 1534 TIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRK 1569
Score = 89.0 bits (219), Expect = 3e-17
Identities = 66/232 (28%), Positives = 108/232 (46%), Gaps = 16/232 (6%)
Query: 629 ITIHSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVS 688
I I + + + P L +N + G + + G G+GKSS A + EG +
Sbjct: 1344 IQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHII 1403
Query: 689 IEGA-VAYVPQEAWVQNTSVV--ENVCFGQ----ELDPP------WLERVLEACALQPDV 735
I+G +A +P S++ + V F LDP L LE L+ V
Sbjct: 1404 IDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVV 1463
Query: 736 DSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQV 795
+ P G+ I E G N S GQ+Q LARA RK +++++D+ A++D +++ +V
Sbjct: 1464 KALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMAT-ENILQKV 1522
Query: 796 IGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGAL 847
+ T + + H +H + AD +IVL GAI E ++LL RK ++
Sbjct: 1523 VMTA--FADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDSV 1572
>gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo
sapiens]
Length = 1464
Score = 603 bits (1556), Expect = e-172
Identities = 443/1377 (32%), Positives = 683/1377 (49%), Gaps = 146/1377 (10%)
Query: 189 QPPFFPEDPQQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLR-PKDLWSLGRENSSEE 247
Q P PED Q E G ++ S+ ++ W++ L+ RG LR P+D+ L
Sbjct: 158 QEPLLPED--QEPEVAEDGESWLSRFSYAWLAPLLARGACGELRQPQDICRLPHRLQPTY 215
Query: 248 LVSRLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVF 307
L + W QEG++ L +A++ F
Sbjct: 216 LARVFQAHW----------------------------------QEGAR---LWRALYGAF 238
Query: 308 HSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFE 367
+L L ++ + F+ P LLSL + F+ + + P G L A+ + A L + +
Sbjct: 239 GRCYLALGLLKLVGTMLGFSGPLLLSLLVGFLEEGQEPLSHGLLYALGLAGGAVLGAVLQ 298
Query: 368 QQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYL 427
Q Y + + ++ R A+ ++Y K L L G+ +NL+ D +RL
Sbjct: 299 NQYGYEVYKVTLQARGAVLNILYCKALQLGPSR---PPTGEALNLLGTDSERLLNFAGSF 355
Query: 428 NGLW-LPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDS 486
+ W LPL + ++ L+Q +G + + + + L L+P+N I+ + +E ++ KD+
Sbjct: 356 HEAWGLPLQLAITLYL-LYQQVGVAFVGGLILALLLVPVNKVIATRIMASNQEMLQHKDA 414
Query: 487 RARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLV 546
R +L + +L + IKF GWE A RV R +ELG LR L + + + ++
Sbjct: 415 RVKLVTELLSGIRVIKFCGWEQALGARVEACRARELGRLRVIKYLDAACVYLWAALPVVI 474
Query: 547 ALVVFAVHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLC 606
++V+F + L+ + A K F L ++ +L P+ I+ L++A+VS DR+ FL
Sbjct: 475 SIVIFITYVLMGHQ-LTATKVFTALALVRMLILPLNNFPWVINGLLEAKVSLDRIQLFLD 533
Query: 607 LEEVDPGVVDSSSSGS--------------AAGKDCITIHSATFAWSQESPPCLHRIN-L 651
L +P S G A + +H A F+W I+ L
Sbjct: 534 LPNHNPQAYYSPDCGRLGAQIKWLLCSDPPAEPSTVLELHGALFSWDPVGTSLETFISHL 593
Query: 652 TVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEG---AVAYVPQEAWVQNTSVV 708
V +G L+ +VG VG GKSSLL+A+ GEL ++ G V++ G QE W+Q ++
Sbjct: 594 EVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKGFGLATQEPWIQFATIR 653
Query: 709 ENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVY 768
+N+ FG+ D + VLEACAL D+ P G T +GE+G+ LSGGQ+ R++LARAVY
Sbjct: 654 DNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVY 713
Query: 769 RKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLAN 828
++ +YLLDDPLAA+DA V H+ ++ I G+L TTR+L TH L +AD ++++
Sbjct: 714 QEKELYLLDDPLAAVDADVANHLLHRCIL--GMLSYTTRLLCTHRTEYLERADAVLLMEA 771
Query: 829 GAIAEMGSYQELLQRKGALVCLLDQARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRE 888
G + G E+L LV + +A + E ++ S ++P T G
Sbjct: 772 GRLIRAGPPSEILP----LVQAVPKAWAENGQ-ESDSATAQSVQNPEKTKEGL------- 819
Query: 889 RSIKSVPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKATVHLAYLRAVGTPLCL 948
E++++TS G ++S + G V V+ AY +AVG L L
Sbjct: 820 -------EEEQSTS--------------GRLLQEESKKEGAVALHVYQAYWKAVGQGLAL 858
Query: 949 YALFLFLCQQVASFCRGYWLSLW-----ADDPAVGGQQTQAALRGGIFGLLGCLQAIG-- 1001
LF L Q +WLS W A++ + Q + + G+F L + G
Sbjct: 859 AILFSLLLMQATRNAADWWLSHWISQLKAENSSQEAQPSTSPASMGLFSPQLLLFSPGNL 918
Query: 1002 -----------------------LFASMAAV------------LLGGARASRLLFQRLLW 1026
++A++A V G +A+ L +RLL
Sbjct: 919 YIPVFPLPKAAPNGSSDIRFYLTVYATIAGVNSLCTLLRAVLFAAGTLQAAATLHRRLLH 978
Query: 1027 DVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPL 1086
V+ +P++FF TP G +LNRFS + D +P L LL A GLL + V+ P
Sbjct: 979 RVLMAPVTFFNATPTGRILNRFSSDVACADDSLPFILNILLANAAGLLGLLAVLGSGLPW 1038
Query: 1087 ATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPF 1146
+ + PL ++Y Q Y SS +LRRL S + S + SH+A+T G +V+RA F
Sbjct: 1039 LLLLLPPLSIMYYHVQRHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRF 1098
Query: 1147 VAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAH--LSAGLVGF 1204
+N ++ +QR F +WL ++L+G +V A A A++ + GLVG
Sbjct: 1099 EEENLRLLELNQRCQFATSATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGL 1158
Query: 1205 SVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWPQGGQ 1264
S+S AL +T L +V ++T E +VSVER+++Y + P P QGG
Sbjct: 1159 SLSYALSLTGLLSGLVSSFTQTEAMLVSVERLEEYTCDLPQEPQGQPLQLGTGWLTQGG- 1217
Query: 1265 IEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIW 1324
+EF+D L YRP LP A+ GV+F + GEK+GIVGRTG+GKSSL L RL E + G +
Sbjct: 1218 VEFQDVVLAYRPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVL 1277
Query: 1325 IDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALV 1384
+DGV + + L LRS+++IIPQ+P LF G++R NLD H D A+W AL+ L ++
Sbjct: 1278 LDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVI 1337
Query: 1385 ASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAML 1444
S+ G L + + G LS+GQ+QLLCLARALL +IL +DEATA+VD T+ +Q +
Sbjct: 1338 TSM-GGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTI 1396
Query: 1445 GSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQ-KGLFYRLAQES 1500
FA TVL IAHRL ++++ RVLV+ G+V E SPA L Q LF +L Q S
Sbjct: 1397 CKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLLQSS 1453
Score = 79.7 bits (195), Expect = 2e-14
Identities = 77/282 (27%), Positives = 120/282 (42%), Gaps = 29/282 (10%)
Query: 596 VSFDRLVTFLCLEEVDPGVVDSSSSGSAAGKDCITIHSATFAWSQESPPCLHRINLTVPQ 655
VS +RL + C +P + + A+ P L + V
Sbjct: 1185 VSVERLEEYTCDLPQEPQGQPLQLGTGWLTQGGVEFQDVVLAYRPGLPNALDGVTFCVQP 1244
Query: 656 GCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGA-------------VAYVPQEAWV 702
G L +VG G+GKSSLL L L G V ++G +A +PQE ++
Sbjct: 1245 GEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPFL 1304
Query: 703 QNTSVVENVCFGQELDPPWLER------VLEACALQPDVDSFPEGIHTSIGEQGMNLSGG 756
+ +V EN LDP L + L+ C L + S G+ +GE G +LS G
Sbjct: 1305 FSGTVREN------LDPQGLHKDRALWQALKQCHLSEVITSMG-GLDGELGEGGRSLSLG 1357
Query: 757 QKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHI 816
Q+Q L LARA+ A + +D+ A++D Q + Q I T + + H L+
Sbjct: 1358 QRQLLCLARALLTDAKILCIDEATASVDQKTDQ-LLQQTICK--RFANKTVLTIAHRLNT 1414
Query: 817 LPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQARQPG 858
+ +D ++VL G + E+ S L + +L L Q+ Q G
Sbjct: 1415 ILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLLQSSQQG 1456
>gi|110832835 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A [Homo sapiens]
Length = 1549
Score = 600 bits (1546), Expect = e-171
Identities = 460/1527 (30%), Positives = 730/1527 (47%), Gaps = 146/1527 (9%)
Query: 67 PLFKAKMVLGFALIVLCTSSVAVALWKIQQGTPEAPEF-LIHPTV--WLTTMSFAVFLIH 123
P + +L FAL+ + +A + + E+ L P V ++ T + V+ +
Sbjct: 67 PGHNLRWILTFALLFVHVCEIAEGI--VSDSRRESRHLHLFMPAVMGFVATTTSIVYYHN 124
Query: 124 TERKKGVQSSGVLFGYWLLCFVLPATNAAQQASGAGFQSDPVRHLSTYLCLSL--VVAQF 181
E + LF YW++ F+ + +G +R T + + L ++
Sbjct: 125 IETSNFPKLLLALFLYWVMAFITKTIKLVKYCQ-SGLDISNLRFCITGMMVILNGLLMAV 183
Query: 182 VLSCLADQPPFFPEDPQQSNP---CPETGAAFP-------SKATFWWVSGLVWRGYRRPL 231
++ + + F +PQ+ P + G F SKAT+WW++ L+ +++P+
Sbjct: 184 EINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPI 243
Query: 232 RPKDLWSLGRENSSEELVSRLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQ 291
DL ++G+ + R ++ + A K +A P P
Sbjct: 244 ---DLKAIGKL----PIAMRAVTNYVCLKDAYEEQKKKVA---------DHPNRTP---- 283
Query: 292 EGSQWRPLLKAIWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDP--------- 342
S W A+++ F LL + ++D+ F P +S ++ + +
Sbjct: 284 --SIWL----AMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTG 337
Query: 343 -------KPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLA 395
K Y+LAVL+FL+ LQ F Q + Y + LR A+ ++Y K+L
Sbjct: 338 ISETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILR 397
Query: 396 LSSG--SRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFVYLWQLLGPSAL 453
LS+ S +G + NLV+++ +L + LW V I++ + L+ LLG SAL
Sbjct: 398 LSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSAL 457
Query: 454 TAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFHGWEGAFLDR 513
AV + L P+ +FI+ K Q+ + R + T+ IL+ K +K + WE F
Sbjct: 458 VGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKS 517
Query: 514 VLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAMNAEKAFVTLTV 573
V R +EL +L+T L S+S+ L F H + N + +AF +L++
Sbjct: 518 VEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSL 577
Query: 574 LNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEE-----------------------V 610
+IL L + V+A +S +L FL +E V
Sbjct: 578 FHILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGV 637
Query: 611 DPGVVDSSSSGS---------------AAGKD-CITIHSATFAWSQESPPCLHRINLTVP 654
P ++ G A +D I + + F+W L I++ +P
Sbjct: 638 QPKTINRKQPGRYHLDSYEQSTRRLRPAETEDIAIKVTNGYFSWGS-GLATLSNIDIRIP 696
Query: 655 QGCLLAVVGPVGAGKSSLLSALLGELSKVEGFV----------SIEG-------AVAYVP 697
G L +VG VG GKSSLL A+LGE+ +EG V S E +VAY
Sbjct: 697 TGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAA 756
Query: 698 QEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQ 757
Q+ W+ N +V EN+ FG + + V +AC+LQPD+D P G T IGE+G+NLSGGQ
Sbjct: 757 QKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQ 816
Query: 758 KQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHIL 817
+QR+ +ARA+Y+ + LDDP +ALD H+ H+ + I T +LVTH L L
Sbjct: 817 RQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYL 876
Query: 818 PQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQARQPGDRGEGETEPGTSTKDPRGT 877
ADWII + +G++ G+ +++ + V L + + +R + E E T
Sbjct: 877 THADWIIAMKDGSVLREGTLKDIQTKD---VELYEHWKTLMNRQDQELEKDMEADQ---T 930
Query: 878 SAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKATVHLA 937
+ R+ R S ++ + + E + E DD ++ R K
Sbjct: 931 TLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDD--------NMSTVMRLRTKMPWKTC 982
Query: 938 --YLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLWADDPAVG--GQQTQAALRGGIFGL 993
YL + G L + +F L + YWL+ W + ++ G+ Q G L
Sbjct: 983 WRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSIL 1042
Query: 994 LGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETD 1053
G + L S+ +G A++ L LL ++ PI FF+ TP+G +LNRFS +T+
Sbjct: 1043 CGAGIFLCLVTSLTVEWMG-LTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTN 1101
Query: 1054 TVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLR 1113
+D IP L SL L +++ ATP+ VA+LPL + + Q + V+S L+
Sbjct: 1102 IIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQ 1161
Query: 1114 RLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRL-VADRWLA 1172
L+ ++ + H +ET +G T +RAFR + F Q + ++ I++ L A+RWL
Sbjct: 1162 ELDDSTQLPLLCHFSETAEGLTTIRAFRHETRF-KQRMLELTDTNNIAYLFLSAANRWLE 1220
Query: 1173 ANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVS 1232
+ LG +V A+ ++ ++ +GLVG + AL +T L WVVRN DLE + +
Sbjct: 1221 VRTDYLGACIVLTASIASISGSSN--SGLVGLGLLYALTITNYLNWVVRNLADLEVQMGA 1278
Query: 1233 VERMQDYAWTPKEAPWRLPTCAAQPP--WPQGGQIEFRDFGLRYRPELPLAVQGVSFKIH 1290
V+++ + T + + +Q P WPQ G+I+ D +RY L ++ V I
Sbjct: 1279 VKKVNSFL-TMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIK 1337
Query: 1291 AGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPI 1350
G+KVGI GRTG+GKSSL+ R+ + +G I IDG+ I+ + LHTLRSR+SII QDPI
Sbjct: 1338 PGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPI 1397
Query: 1351 LFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLL 1410
LF GS+R NLD + +D+ +W ALE QLK +V SLPG L + GE+ SVGQ+QL
Sbjct: 1398 LFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLF 1457
Query: 1411 CLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVL 1470
CLARA +RK+ ILI+DEATA++D TE +Q ++ + FA TV+ IAHR+ S+MD VL
Sbjct: 1458 CLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVL 1517
Query: 1471 VMDKGQVAESGSPAQLLAQK-GLFYRL 1496
V +G + E + LLA K GLF L
Sbjct: 1518 VFSEGILVECDTVPNLLAHKNGLFSTL 1544
>gi|110832837 ATP-binding cassette, sub-family C, member 9 isoform
SUR2B [Homo sapiens]
Length = 1549
Score = 599 bits (1544), Expect = e-171
Identities = 456/1524 (29%), Positives = 731/1524 (47%), Gaps = 146/1524 (9%)
Query: 67 PLFKAKMVLGFALIVLCTSSVAVALWKIQQGTPEAPEF-LIHPTV--WLTTMSFAVFLIH 123
P + +L FAL+ + +A + + E+ L P V ++ T + V+ +
Sbjct: 67 PGHNLRWILTFALLFVHVCEIAEGI--VSDSRRESRHLHLFMPAVMGFVATTTSIVYYHN 124
Query: 124 TERKKGVQSSGVLFGYWLLCFVLPATNAAQQASGAGFQSDPVRHLSTYLCLSL--VVAQF 181
E + LF YW++ F+ + +G +R T + + L ++
Sbjct: 125 IETSNFPKLLLALFLYWVMAFITKTIKLVKYCQ-SGLDISNLRFCITGMMVILNGLLMAV 183
Query: 182 VLSCLADQPPFFPEDPQQSNP---CPETGAAFP-------SKATFWWVSGLVWRGYRRPL 231
++ + + F +PQ+ P + G F SKAT+WW++ L+ +++P+
Sbjct: 184 EINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPI 243
Query: 232 RPKDLWSLGRENSSEELVSRLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQ 291
DL ++G+ + R ++ + A K +A P P
Sbjct: 244 ---DLKAIGKL----PIAMRAVTNYVCLKDAYEEQKKKVA---------DHPNRTP---- 283
Query: 292 EGSQWRPLLKAIWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDP--------- 342
S W A+++ F LL + ++D+ F P +S ++ + +
Sbjct: 284 --SIWL----AMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTG 337
Query: 343 -------KPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLA 395
K Y+LAVL+FL+ LQ F Q + Y + LR A+ ++Y K+L
Sbjct: 338 ISETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILR 397
Query: 396 LSSG--SRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFVYLWQLLGPSAL 453
LS+ S +G + NLV+++ +L + LW V I++ + L+ LLG SAL
Sbjct: 398 LSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSAL 457
Query: 454 TAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFHGWEGAFLDR 513
AV + L P+ +FI+ K Q+ + R + T+ IL+ K +K + WE F
Sbjct: 458 VGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKS 517
Query: 514 VLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAMNAEKAFVTLTV 573
V R +EL +L+T L S+S+ L F H + N + +AF +L++
Sbjct: 518 VEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSL 577
Query: 574 LNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEE-----------------------V 610
+IL L + V+A +S +L FL +E V
Sbjct: 578 FHILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGV 637
Query: 611 DPGVVDSSSSGS---------------AAGKD-CITIHSATFAWSQESPPCLHRINLTVP 654
P ++ G A +D I + + F+W L I++ +P
Sbjct: 638 QPKTINRKQPGRYHLDSYEQSTRRLRPAETEDIAIKVTNGYFSWGS-GLATLSNIDIRIP 696
Query: 655 QGCLLAVVGPVGAGKSSLLSALLGELSKVEGFV----------SIEG-------AVAYVP 697
G L +VG VG GKSSLL A+LGE+ +EG V S E +VAY
Sbjct: 697 TGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAA 756
Query: 698 QEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQ 757
Q+ W+ N +V EN+ FG + + V +AC+LQPD+D P G T IGE+G+NLSGGQ
Sbjct: 757 QKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQ 816
Query: 758 KQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHIL 817
+QR+ +ARA+Y+ + LDDP +ALD H+ H+ + I T +LVTH L L
Sbjct: 817 RQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYL 876
Query: 818 PQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQARQPGDRGEGETEPGTSTKDPRGT 877
ADWII + +G++ G+ +++ + V L + + +R + E E T
Sbjct: 877 THADWIIAMKDGSVLREGTLKDIQTKD---VELYEHWKTLMNRQDQELEKDMEADQ---T 930
Query: 878 SAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKATVHLA 937
+ R+ R S ++ + + E + E DD ++ R K
Sbjct: 931 TLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDD--------NMSTVMRLRTKMPWKTC 982
Query: 938 --YLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLWADDPAVG--GQQTQAALRGGIFGL 993
YL + G L + +F L + YWL+ W + ++ G+ Q G L
Sbjct: 983 WRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSIL 1042
Query: 994 LGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETD 1053
G + L S+ +G A++ L LL ++ PI FF+ TP+G +LNRFS +T+
Sbjct: 1043 CGAGIFLCLVTSLTVEWMG-LTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTN 1101
Query: 1054 TVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLR 1113
+D IP L SL L +++ ATP+ VA+LPL + + Q + V+S L+
Sbjct: 1102 IIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQ 1161
Query: 1114 RLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRL-VADRWLA 1172
L+ ++ + H +ET +G T +RAFR + F Q + ++ I++ L A+RWL
Sbjct: 1162 ELDDSTQLPLLCHFSETAEGLTTIRAFRHETRF-KQRMLELTDTNNIAYLFLSAANRWLE 1220
Query: 1173 ANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVS 1232
+ LG +V A+ ++ ++ +GLVG + AL +T L WVVRN DLE + +
Sbjct: 1221 VRTDYLGACIVLTASIASISGSSN--SGLVGLGLLYALTITNYLNWVVRNLADLEVQMGA 1278
Query: 1233 VERMQDYAWTPKEAPWRLPTCAAQPP--WPQGGQIEFRDFGLRYRPELPLAVQGVSFKIH 1290
V+++ + T + + +Q P WPQ G+I+ D +RY L ++ V I
Sbjct: 1279 VKKVNSFL-TMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIK 1337
Query: 1291 AGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPI 1350
G+KVGI GRTG+GKSSL+ R+ + +G I IDG+ I+ + LHTLRSR+SII QDPI
Sbjct: 1338 PGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPI 1397
Query: 1351 LFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLL 1410
LF GS+R NLD + +D+ +W ALE QLK +V SLPG L + GE+ SVGQ+QL
Sbjct: 1398 LFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLF 1457
Query: 1411 CLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVL 1470
CLARA +RK+ ILI+DEATA++D TE +Q ++ + FA TV+ IAHR+ +++ V+
Sbjct: 1458 CLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILTADLVI 1517
Query: 1471 VMDKGQVAESGSPAQLLAQK-GLF 1493
VM +G + E +P LLAQ+ G+F
Sbjct: 1518 VMKRGNILEYDTPESLLAQENGVF 1541
>gi|89111135 ATP-binding cassette protein C12 [Homo sapiens]
Length = 1359
Score = 583 bits (1503), Expect = e-166
Identities = 413/1368 (30%), Positives = 678/1368 (49%), Gaps = 145/1368 (10%)
Query: 202 PCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRS 261
P P A S ATF W++ ++ +GYR+ L L L +SS+ R W
Sbjct: 43 PNPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLW----- 97
Query: 262 AARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIIS 321
+ + + G + L +W+ + L+ ++ I+
Sbjct: 98 ------------------------DEEVARVGPEKASLSHVVWKFQRTRVLMDIVANILC 133
Query: 322 DVFRFTVPKLL-SLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKVLQMR 380
+ P +L L+ W G L + +F + + F +R
Sbjct: 134 IIMAAIGPVILIHQILQQTERTSGKVWVGIGLCIALFATEFTKVFFWALAWAINYRTAIR 193
Query: 381 LRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVC 440
L+ A++ LV+ +++ + + +VG+V+N++S D L E+ L+ + +V C
Sbjct: 194 LKVALSTLVFENLVSFKTLTH--ISVGEVLNILSSDSYSLFEAALFCPLPATIPILMVFC 251
Query: 441 FVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKT 500
Y + +LGP+AL I+V++ +P+ F++K + + + D R + + L +
Sbjct: 252 AAYAFFILGPTALIGISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRL 311
Query: 501 IKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAEN 560
IK + WE +F + + IR +E L +G + S + + + + ++ + H L+
Sbjct: 312 IKMYAWEKSFTNTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTLSCHILLRRK 371
Query: 561 AMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLC--------LEEVDP 612
+ A AF + + N++ + A LPFSI ++ +A VS R+ L + DP
Sbjct: 372 -LTAPVAFSVIAMFNVMKFSIAILPFSIKAMAEANVSLRRMKKILIDKSPPSYITQPEDP 430
Query: 613 GVV----------DSSSSGSAAGKDC------ITIHSATFAWSQESPPC----------- 645
V + +S + K + + A+S+ SPP
Sbjct: 431 DTVLLLANATLTWEHEASRKSTPKKLQNQKRHLCKKQRSEAYSERSPPAKGATGPEEQSD 490
Query: 646 -----LHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEA 700
LH I+ V +G +L + G VG+GKSSLL+ALLG++ +G V++ G +AYV Q+A
Sbjct: 491 SLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGTLAYVSQQA 550
Query: 701 WVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQR 760
W+ + +V EN+ FG++ D + + C LQ D+ + P G T IGE+G+NLSGGQ+QR
Sbjct: 551 WIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERGLNLSGGQRQR 610
Query: 761 LSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQA 820
+SLARAVY +YLLDDPL+A+DAHVG+HVF + I L+G T +LVTH L L
Sbjct: 611 ISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKK--TLRGKTVVLVTHQLQFLESC 668
Query: 821 DWIIVLANGAIAEMGSYQELLQRKGALVCLLDQARQPGDRGEGETEPGTSTKDPRG---- 876
D +I+L +G I E G+++EL++ +G L+ R G KDP
Sbjct: 669 DEVILLEDGEICEKGTHKELMEERGRYAKLIHNLR------------GLQFKDPEHLYNA 716
Query: 877 --TSAGRRPELRRERSI----------KSVPEKDRTTSE-AQTEVPLDDPDRAGWPAGKD 923
A + RE K ++ T SE T+VP + +
Sbjct: 717 AMVEAFKESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVDTKVPEHQLIQT------E 770
Query: 924 SIQYGRVKATVHLAYLRAV-GTPLCLYALFLFLCQQVASFCRGYWLSLWADDPA-----V 977
S Q G V + Y++A G L L+ +FLFL ++ +WL LW D +
Sbjct: 771 SPQEGTVTWKTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGLWLDKGSRMTCGP 830
Query: 978 GGQQTQAALRGGIFGLLGCLQAIGLF-ASMAAVLLGGA-----------RASRLLFQRLL 1025
G +T + G + +G ++ ASM +L+ G AS L +
Sbjct: 831 QGNRTMCEV-GAVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVF 889
Query: 1026 WDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATP 1085
+++SP+SFF+ TP G L+NRFSK+ D +DV +P + L F ++ + +++A P
Sbjct: 890 DKILKSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILVILAAVFP 949
Query: 1086 LATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAP 1145
+ + L + + ++ +L+++E+ S S +H+ + QG ++ A+ +
Sbjct: 950 AVLLVVASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQGLGIIHAYGKKES 1009
Query: 1146 FVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFS 1205
+ + + A RW A +++L N L F A LS + +S G S
Sbjct: 1010 CITYHLLYFN----------CALRWFALRMDVLMNILTFTVALLVTLSFSSISTSSKGLS 1059
Query: 1206 VSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWT--PK-EAPWRLPTCAAQPPWPQG 1262
+S +Q++ LQ VR T+ + SVE +++Y T P+ P ++ TC WP
Sbjct: 1060 LSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYISTCVPECTHPLKVGTCPKD--WPSR 1117
Query: 1263 GQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGG 1322
G+I FRD+ +RYR PL + ++ I +G+ VGIVGRTG+GKSSL L RL E A G
Sbjct: 1118 GEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGT 1177
Query: 1323 IWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKA 1382
I+ID V I + L LR+++++IPQDP+LF G++R NLD + H+DE +W LE ++
Sbjct: 1178 IFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEMLWQVLERTFMRD 1237
Query: 1383 LVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQA 1442
+ LP +LQ + + GE+ SVG++QLLC+ARALLR ++I++LDEATA++D T+ +Q
Sbjct: 1238 TIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTDTLVQN 1297
Query: 1443 MLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQK 1490
+ F CTVL IAHRL +V++C VLVM+ G+V E P ++LA+K
Sbjct: 1298 TIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKP-EVLAEK 1344
Score = 89.7 bits (221), Expect = 2e-17
Identities = 55/220 (25%), Positives = 114/220 (51%), Gaps = 14/220 (6%)
Query: 1278 LPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHT 1337
L + +SF + G+ +GI G G+GKSSL + LL + +G + ++G
Sbjct: 492 LKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGT--------- 542
Query: 1338 LRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCAD 1397
++ + Q +F G++R N+ +++ + + L+ +++LP + +
Sbjct: 543 ----LAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGE 598
Query: 1398 RGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQM-QAMLGSWFAQCTVLLI 1456
RG +LS GQ+Q + LARA+ Q+ +LD+ +AVD + + + TV+L+
Sbjct: 599 RGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLV 658
Query: 1457 AHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRL 1496
H+L+ + C V++++ G++ E G+ +L+ ++G + +L
Sbjct: 659 THQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKL 698
Score = 87.4 bits (215), Expect = 9e-17
Identities = 101/492 (20%), Positives = 203/492 (41%), Gaps = 44/492 (8%)
Query: 383 SAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFV 442
S++ V+ K+L + G ++N S D+ L + + +L ++VV +
Sbjct: 882 SSLHDTVFDKILKSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFIL 941
Query: 443 YLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRAR------LTSSILR 496
+ + P+ L +A L + FFI + H +++++ ++ +R +TSS+
Sbjct: 942 VILAAVFPAVLLVVAS----LAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQG 997
Query: 497 NSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHTL 556
+ E +L ALR L V + + TF VAL+V +
Sbjct: 998 LGIIHAYGKKESCITYHLLYFNC----ALRWFALRMDVLM---NILTFTVALLVTLSFSS 1050
Query: 557 VAENAMNAEKAFVT----LTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDP 612
++ ++ +++ L + + + F+ L++ +S C+ E
Sbjct: 1051 ISTSSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYIS-------TCVPECTH 1103
Query: 613 GVVDSSSSGSAAGKDCITIHSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSL 672
+ + + IT + +P L +NL + G + +VG G+GKSSL
Sbjct: 1104 PLKVGTCPKDWPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSL 1163
Query: 673 LSALLGELSKVEGFVSIEGA-------------VAYVPQEAWVQNTSVVENVCFGQELDP 719
AL + G + I+ + +PQ+ + +V N+ +
Sbjct: 1164 GMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTD 1223
Query: 720 PWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDP 779
L +VLE ++ + PE + + E G N S G++Q L +ARA+ R + + LLD+
Sbjct: 1224 EMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEA 1283
Query: 780 LAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQE 839
A++D+ V N + +G T + + H L+ + D ++V+ NG + E +
Sbjct: 1284 TASMDSKTDTLVQNTI---KDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEV 1340
Query: 840 LLQRKGALVCLL 851
L ++ + +L
Sbjct: 1341 LAEKPDSAFAML 1352
>gi|21729873 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 568 bits (1464), Expect = e-161
Identities = 416/1373 (30%), Positives = 655/1373 (47%), Gaps = 144/1373 (10%)
Query: 191 PFFPEDPQQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVS 250
PF P+ P+ P P A S T W++ L+ + R L + L ++S++ V
Sbjct: 73 PFRPK-PRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQ 131
Query: 251 RLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQV-FHS 309
RL + W S R+G KA LR + + R + A+ + F
Sbjct: 132 RLHRLWEEEVS------------RRGIE--KASVLLVMLRFQRT--RLIFDALLGICFCI 175
Query: 310 TFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQ 369
+LG + +I PK+L E +G+ G L +FLS C+++L
Sbjct: 176 ASVLGPILII---------PKILEYSEEQLGN----VVHGVGLCFALFLSECVKSLSFSS 222
Query: 370 NMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNG 429
+ + +R R+A++ + K++ S S G+ ++ + DV L E V Y
Sbjct: 223 SWIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPL 280
Query: 430 LWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISK---KRNHHQEEQMRQKDS 486
+ + +V+C + + ++G +A AI +L + PL F+++ K HH E D
Sbjct: 281 VLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEV---SDQ 337
Query: 487 RARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLV 546
R R+TS +L K IK + WE F + +R +E L GL+ S++ ++ + +
Sbjct: 338 RIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVA 397
Query: 547 ALVVFAVHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLC 606
V +HT + + + A AF L LN+L + F+P ++ L ++ + R F
Sbjct: 398 TAVWVLIHTSL-KLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFF- 455
Query: 607 LEEVDPGVVDSSSSGSAAGKDCITIHSATFAWSQESP----------------------- 643
L+E V + S A + AT +W Q P
Sbjct: 456 LQESPVFYVQTLQDPSKA----LVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPR 511
Query: 644 -------------PCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIE 690
P LH+INL V +G +L V G G+GKSSLLSA+L E+ +EG V ++
Sbjct: 512 DALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQ 571
Query: 691 GAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQG 750
G++AYVPQ+AW+ + ++ EN+ G D +VL C+L D++ P G T IGE+G
Sbjct: 572 GSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERG 631
Query: 751 MNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILV 810
+NLSGGQKQR+SLARAVY +YLLDDPL+A+DAHVG+H+F + I L+G T +LV
Sbjct: 632 LNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKK--TLRGKTVVLV 689
Query: 811 THALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQARQPGDRGEGETEPGTS 870
TH L L II+L NG I E G++ EL+Q+KG L+ + + + +
Sbjct: 690 THQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAKIA 749
Query: 871 TKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRV 930
K P+ S L + +VPE T E E G +
Sbjct: 750 EK-PKVESQALATSLEESLNGNAVPEHQLTQEEEMEE--------------------GSL 788
Query: 931 KATVHLAYLRAVGTPLCLYALFLFLCQQV-ASFCRGYWLSLW------------------ 971
V+ Y++A G + +F F+ V + +WLS W
Sbjct: 789 SWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMA 848
Query: 972 -----ADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLW 1026
AD+P + Q L + +G + G+F + +AS L +L
Sbjct: 849 DLGNIADNPQLSFYQLVYGLNALLLICVGVCSS-GIFTKVTR------KASTALHNKLFN 901
Query: 1027 DVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATP- 1085
V R P+SFF+ PIG LLN F+ + + +D +P L+ + ++ V L+V+V +P
Sbjct: 902 KVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPY 961
Query: 1086 ---LATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRT 1142
+ + ++ F+ Y F+ V +RLE+ S S + SH+ + QG + + +
Sbjct: 962 ILLMGAIIMVICFIYYMMFKKAIGV----FKRLENYSRSPLFSHILNSLQGLSSIHVYGK 1017
Query: 1143 QAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLV 1202
F++Q D L + RW+A +E++ N + A A +
Sbjct: 1018 TEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFK 1077
Query: 1203 GFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYA-WTPKEAPWRLPTCAAQPPWPQ 1261
+V+ LQ+ + Q R + E +VER+ Y EAP + + WPQ
Sbjct: 1078 VMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQ 1137
Query: 1262 GGQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEG 1321
G+I F+D+ ++YR P + G++ I E VGIVGRTG+GKSSL L RL E G
Sbjct: 1138 HGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197
Query: 1322 GIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLK 1381
I IDGV I +GL LRS++S+IPQDP+L G++R NLD H+D+ IW ALE L
Sbjct: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLT 1257
Query: 1382 ALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQ 1441
++ P +L + G + SVG++QLLC+ARA+LR ++I+++DEATA++D T+ +Q
Sbjct: 1258 KAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTLIQ 1317
Query: 1442 AMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFY 1494
+ F CTVL+IAHR+ +V++C +LVM G+V E P L + G +
Sbjct: 1318 RTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLF 1370
Score = 99.8 bits (247), Expect = 2e-20
Identities = 106/491 (21%), Positives = 209/491 (42%), Gaps = 32/491 (6%)
Query: 383 SAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFV 442
+A+ ++ KV +G ++N + D+++L + + + +L L +V+ +
Sbjct: 893 TALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVL 952
Query: 443 YLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSK--- 499
+ +L P L A+ + + + + + KK + + SR+ L S IL + +
Sbjct: 953 LIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRL--ENYSRSPLFSHILNSLQGLS 1010
Query: 500 TIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSL----VSFQVSTFLVALVVFAVHT 555
+I +G F+ + + + L LLF S + ++ T LV L V
Sbjct: 1011 SIHVYGKTEDFISQFKRLTDAQNNYL----LLFLSSTRWMALRLEIMTNLVTLAVALFVA 1066
Query: 556 LVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFL--CLEEVDPG 613
+ + K VL + + QA + + Q + +R++ ++ C+ E
Sbjct: 1067 FGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQF-TAVERILQYMKMCVSEAPLH 1125
Query: 614 VVDSSSSGSAAGKDCITIHSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLL 673
+ +S I + +P LH INLT+ ++ +VG G+GKSSL
Sbjct: 1126 MEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLG 1185
Query: 674 SALLGELSKVEGFVSIEGA-------------VAYVPQEAWVQNTSVVENVCFGQELDPP 720
AL + + G + I+G ++ +PQ+ + + ++ N+
Sbjct: 1186 MALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQ 1245
Query: 721 WLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPL 780
+ LE L + FP+ +HT + E G N S G++Q L +ARAV R + + L+D+
Sbjct: 1246 QIWDALERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEAT 1305
Query: 781 AALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQEL 840
A++D + + QG T +++ H + + D I+V+ NG + E + L
Sbjct: 1306 ASIDMETDTLIQRTI---REAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVL 1362
Query: 841 LQRKGALVCLL 851
++ G+L L
Sbjct: 1363 RKKPGSLFAAL 1373
Score = 92.4 bits (228), Expect = 3e-18
Identities = 57/216 (26%), Positives = 109/216 (50%), Gaps = 14/216 (6%)
Query: 1285 VSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISI 1344
++ + G +G+ G TG+GKSSL S +L EG + + G ++
Sbjct: 530 INLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------SLAY 576
Query: 1345 IPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSV 1404
+PQ + G++R N+ + + L L + LP + +RG +LS
Sbjct: 577 VPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSG 636
Query: 1405 GQKQLLCLARALLRKTQILILDEATAAVDPGTELQM-QAMLGSWFAQCTVLLIAHRLRSV 1463
GQKQ + LARA+ QI +LD+ +AVD + + + TV+L+ H+L+ +
Sbjct: 637 GQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYL 696
Query: 1464 MDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQE 1499
C ++++++ G++ E+G+ ++L+ +KG + +L Q+
Sbjct: 697 EFCGQIILLENGKICENGTHSELMQKKGKYAQLIQK 732
>gi|15149474 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 568 bits (1464), Expect = e-161
Identities = 416/1373 (30%), Positives = 655/1373 (47%), Gaps = 144/1373 (10%)
Query: 191 PFFPEDPQQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVS 250
PF P+ P+ P P A S T W++ L+ + R L + L ++S++ V
Sbjct: 73 PFRPK-PRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQ 131
Query: 251 RLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQV-FHS 309
RL + W S R+G KA LR + + R + A+ + F
Sbjct: 132 RLHRLWEEEVS------------RRGIE--KASVLLVMLRFQRT--RLIFDALLGICFCI 175
Query: 310 TFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQ 369
+LG + +I PK+L E +G+ G L +FLS C+++L
Sbjct: 176 ASVLGPILII---------PKILEYSEEQLGN----VVHGVGLCFALFLSECVKSLSFSS 222
Query: 370 NMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNG 429
+ + +R R+A++ + K++ S S G+ ++ + DV L E V Y
Sbjct: 223 SWIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPL 280
Query: 430 LWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISK---KRNHHQEEQMRQKDS 486
+ + +V+C + + ++G +A AI +L + PL F+++ K HH E D
Sbjct: 281 VLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEV---SDQ 337
Query: 487 RARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLV 546
R R+TS +L K IK + WE F + +R +E L GL+ S++ ++ + +
Sbjct: 338 RIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVA 397
Query: 547 ALVVFAVHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLC 606
V +HT + + + A AF L LN+L + F+P ++ L ++ + R F
Sbjct: 398 TAVWVLIHTSL-KLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFF- 455
Query: 607 LEEVDPGVVDSSSSGSAAGKDCITIHSATFAWSQESP----------------------- 643
L+E V + S A + AT +W Q P
Sbjct: 456 LQESPVFYVQTLQDPSKA----LVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPR 511
Query: 644 -------------PCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIE 690
P LH+INL V +G +L V G G+GKSSLLSA+L E+ +EG V ++
Sbjct: 512 DALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQ 571
Query: 691 GAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQG 750
G++AYVPQ+AW+ + ++ EN+ G D +VL C+L D++ P G T IGE+G
Sbjct: 572 GSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERG 631
Query: 751 MNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILV 810
+NLSGGQKQR+SLARAVY +YLLDDPL+A+DAHVG+H+F + I L+G T +LV
Sbjct: 632 LNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKK--TLRGKTVVLV 689
Query: 811 THALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQARQPGDRGEGETEPGTS 870
TH L L II+L NG I E G++ EL+Q+KG L+ + + + +
Sbjct: 690 THQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAKIA 749
Query: 871 TKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRV 930
K P+ S L + +VPE T E E G +
Sbjct: 750 EK-PKVESQALATSLEESLNGNAVPEHQLTQEEEMEE--------------------GSL 788
Query: 931 KATVHLAYLRAVGTPLCLYALFLFLCQQV-ASFCRGYWLSLW------------------ 971
V+ Y++A G + +F F+ V + +WLS W
Sbjct: 789 SWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMA 848
Query: 972 -----ADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLW 1026
AD+P + Q L + +G + G+F + +AS L +L
Sbjct: 849 DLGNIADNPQLSFYQLVYGLNALLLICVGVCSS-GIFTKVTR------KASTALHNKLFN 901
Query: 1027 DVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATP- 1085
V R P+SFF+ PIG LLN F+ + + +D +P L+ + ++ V L+V+V +P
Sbjct: 902 KVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPY 961
Query: 1086 ---LATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRT 1142
+ + ++ F+ Y F+ V +RLE+ S S + SH+ + QG + + +
Sbjct: 962 ILLMGAIIMVICFIYYMMFKKAIGV----FKRLENYSRSPLFSHILNSLQGLSSIHVYGK 1017
Query: 1143 QAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLV 1202
F++Q D L + RW+A +E++ N + A A +
Sbjct: 1018 TEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFK 1077
Query: 1203 GFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYA-WTPKEAPWRLPTCAAQPPWPQ 1261
+V+ LQ+ + Q R + E +VER+ Y EAP + + WPQ
Sbjct: 1078 VMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQ 1137
Query: 1262 GGQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEG 1321
G+I F+D+ ++YR P + G++ I E VGIVGRTG+GKSSL L RL E G
Sbjct: 1138 HGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197
Query: 1322 GIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLK 1381
I IDGV I +GL LRS++S+IPQDP+L G++R NLD H+D+ IW ALE L
Sbjct: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLT 1257
Query: 1382 ALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQ 1441
++ P +L + G + SVG++QLLC+ARA+LR ++I+++DEATA++D T+ +Q
Sbjct: 1258 KAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTLIQ 1317
Query: 1442 AMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFY 1494
+ F CTVL+IAHR+ +V++C +LVM G+V E P L + G +
Sbjct: 1318 RTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLF 1370
Score = 99.8 bits (247), Expect = 2e-20
Identities = 106/491 (21%), Positives = 209/491 (42%), Gaps = 32/491 (6%)
Query: 383 SAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFV 442
+A+ ++ KV +G ++N + D+++L + + + +L L +V+ +
Sbjct: 893 TALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVL 952
Query: 443 YLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSK--- 499
+ +L P L A+ + + + + + KK + + SR+ L S IL + +
Sbjct: 953 LIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRL--ENYSRSPLFSHILNSLQGLS 1010
Query: 500 TIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSL----VSFQVSTFLVALVVFAVHT 555
+I +G F+ + + + L LLF S + ++ T LV L V
Sbjct: 1011 SIHVYGKTEDFISQFKRLTDAQNNYL----LLFLSSTRWMALRLEIMTNLVTLAVALFVA 1066
Query: 556 LVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFL--CLEEVDPG 613
+ + K VL + + QA + + Q + +R++ ++ C+ E
Sbjct: 1067 FGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQF-TAVERILQYMKMCVSEAPLH 1125
Query: 614 VVDSSSSGSAAGKDCITIHSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLL 673
+ +S I + +P LH INLT+ ++ +VG G+GKSSL
Sbjct: 1126 MEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLG 1185
Query: 674 SALLGELSKVEGFVSIEGA-------------VAYVPQEAWVQNTSVVENVCFGQELDPP 720
AL + + G + I+G ++ +PQ+ + + ++ N+
Sbjct: 1186 MALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQ 1245
Query: 721 WLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPL 780
+ LE L + FP+ +HT + E G N S G++Q L +ARAV R + + L+D+
Sbjct: 1246 QIWDALERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEAT 1305
Query: 781 AALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQEL 840
A++D + + QG T +++ H + + D I+V+ NG + E + L
Sbjct: 1306 ASIDMETDTLIQRTI---REAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVL 1362
Query: 841 LQRKGALVCLL 851
++ G+L L
Sbjct: 1363 RKKPGSLFAAL 1373
Score = 92.4 bits (228), Expect = 3e-18
Identities = 57/216 (26%), Positives = 109/216 (50%), Gaps = 14/216 (6%)
Query: 1285 VSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISI 1344
++ + G +G+ G TG+GKSSL S +L EG + + G ++
Sbjct: 530 INLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------SLAY 576
Query: 1345 IPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSV 1404
+PQ + G++R N+ + + L L + LP + +RG +LS
Sbjct: 577 VPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSG 636
Query: 1405 GQKQLLCLARALLRKTQILILDEATAAVDPGTELQM-QAMLGSWFAQCTVLLIAHRLRSV 1463
GQKQ + LARA+ QI +LD+ +AVD + + + TV+L+ H+L+ +
Sbjct: 637 GQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYL 696
Query: 1464 MDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQE 1499
C ++++++ G++ E+G+ ++L+ +KG + +L Q+
Sbjct: 697 EFCGQIILLENGKICENGTHSELMQKKGKYAQLIQK 732
>gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform 1
[Homo sapiens]
Length = 1437
Score = 530 bits (1364), Expect = e-150
Identities = 317/864 (36%), Positives = 478/864 (55%), Gaps = 46/864 (5%)
Query: 646 LHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNT 705
LH I+L + +G L+ + G VG+GK+SL+SA+LG+++ +EG ++I G AYV Q+AW+ N
Sbjct: 578 LHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGTFAYVAQQAWILNA 637
Query: 706 SVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLAR 765
++ +N+ FG+E D VL +C L+PD+ P T IGE+G NLSGGQ+QR+SLAR
Sbjct: 638 TLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLAR 697
Query: 766 AVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIV 825
A+Y ++Y+LDDPL+ALDAHVG H+FN I L+ T + VTH L L D +I
Sbjct: 698 ALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKH--LKSKTVLFVTHQLQYLVDCDEVIF 755
Query: 826 LANGAIAEMGSYQELLQRKGALVCLLDQARQPGDRGEGETEPGTSTKDPRGTSAGRRPEL 885
+ G I E G+++EL+ G + + GET P + TS ++
Sbjct: 756 MKEGCITERGTHEELMNLNGDYATIFNNLLL------GETPP-VEINSKKETSGSQKKSQ 808
Query: 886 RRERSIKSVPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKATVHLAYLRAVGTP 945
+ SV ++ E V L++ + G V +V+ Y++A G P
Sbjct: 809 DKGPKTGSVKKEKAVKPEEGQLVQLEEKGQ------------GSVPWSVYGVYIQAAGGP 856
Query: 946 LC-LYALFLFLCQQVASFCRGYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQA----- 999
L L + LF+ ++ +WLS W G RG + ++
Sbjct: 857 LAFLVIMALFMLNVGSTAFSTWWLSYWIKQ----GSGNTTVTRGNETSVSDSMKDNPHMQ 912
Query: 1000 --IGLFASMAAVLL------------GGARASRLLFQRLLWDVVRSPISFFERTPIGHLL 1045
++A AV+L G RAS L L ++RSP+ FF+ TP G +L
Sbjct: 913 YYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRIL 972
Query: 1046 NRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLY 1105
NRFSK+ D VDV +P + + + ++A P VA+ PL +L++ +
Sbjct: 973 NRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVS 1032
Query: 1106 VVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRL 1165
V +L+RL++ + S SH+ + QG + A+ F+ + +D++Q F
Sbjct: 1033 RVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFT 1092
Query: 1166 VADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTD 1225
A RWLA ++L+ L+ VL + G ++S A+Q+T Q+ VR ++
Sbjct: 1093 CAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLASE 1152
Query: 1226 LENSIVSVERMQDYAWTPK-EAPWRLPTCAAQPPWPQGGQIEFRDFGLRYRPELPLAVQG 1284
E SVER+ Y T EAP R+ A P WPQ G++ F + +RYR LPL ++
Sbjct: 1153 TEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVLKK 1212
Query: 1285 VSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISI 1344
VSF I EK+GIVGRTG+GKSSL L RL E + G I IDGV I+ +GL LRS++SI
Sbjct: 1213 VSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSI 1272
Query: 1345 IPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSV 1404
IPQ+P+LF G++R NLD +++++ IW ALE +K +A LP +L+ + + G++ SV
Sbjct: 1273 IPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSV 1332
Query: 1405 GQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVM 1464
G++QLLC+ARALLR +ILILDEATAA+D T+L +Q + FA CT+L IAHRL +V+
Sbjct: 1333 GERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVL 1392
Query: 1465 DCARVLVMDKGQVAESGSPAQLLA 1488
R++V+ +GQV E +P+ LL+
Sbjct: 1393 GSDRIMVLAQGQVVEFDTPSVLLS 1416
Score = 119 bits (299), Expect = 2e-26
Identities = 106/437 (24%), Positives = 190/437 (43%), Gaps = 39/437 (8%)
Query: 204 PETGAAFPSKATFWWVSGLVWRGYRR-PLRPKDLWSLGRENSSEELVSRLEKEWMRNRSA 262
P A S TF W+S L +++ L +D+WSL + SS+ RLE+ W
Sbjct: 100 PVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEE--- 156
Query: 263 ARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIISD 322
L + G L + +W + +L + L+I+
Sbjct: 157 --------------------------LNEVGPDAASLRRVVWIFCRTRLILSIVCLMITQ 190
Query: 323 VFRFTVPK-LLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKVLQMRL 381
+ F+ P ++ LE+ + LL + + L+ +++ +RL
Sbjct: 191 LAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTWALNYRTGVRL 250
Query: 382 RSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCF 441
R AI + ++K+L L + K+ +G+++N+ S D QR+ E+ + L V ++
Sbjct: 251 RGAILTMAFKKILKLKNIKEKS--LGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGM 308
Query: 442 VYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTI 501
+Y +LGP+ AVF+ P F S+ + + + + D R + + +L K I
Sbjct: 309 IYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMNEVLTYIKFI 368
Query: 502 KFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENA 561
K + W AF V IR +E L +G S+++ + + ++V F+VH + +
Sbjct: 369 KMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHMTLGFD- 427
Query: 562 MNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDPGVVDSSSSG 621
+ A +AF +TV N + A PFS+ SL +A V+ DR + +EE V +
Sbjct: 428 LTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEE-----VHMIKNK 482
Query: 622 SAAGKDCITIHSATFAW 638
A+ I + +AT AW
Sbjct: 483 PASPHIKIEMKNATLAW 499
Score = 89.7 bits (221), Expect = 2e-17
Identities = 63/216 (29%), Positives = 104/216 (48%), Gaps = 16/216 (7%)
Query: 1278 LPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHT 1337
L + + +I G+ VGI G G+GK+SL S +L EG I I G
Sbjct: 574 LQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGT--------- 624
Query: 1338 LRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCAD 1397
+ + Q + +LR N+ +E+ +E + L + L+ +A LP + +
Sbjct: 625 ----FAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGE 680
Query: 1398 RGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDP--GTELQMQAMLGSWFAQCTVLL 1455
RG +LS GQ+Q + LARAL I ILD+ +A+D G + + + TVL
Sbjct: 681 RGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHI-FNSAIRKHLKSKTVLF 739
Query: 1456 IAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKG 1491
+ H+L+ ++DC V+ M +G + E G+ +L+ G
Sbjct: 740 VTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNG 775
Score = 74.3 bits (181), Expect = 8e-13
Identities = 58/226 (25%), Positives = 104/226 (46%), Gaps = 16/226 (7%)
Query: 629 ITIHSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSAL--LGELS----K 682
+T +A + + P L +++ T+ + +VG G+GKSSL AL L ELS K
Sbjct: 1193 VTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIK 1252
Query: 683 VE-------GFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDV 735
++ G + ++ +PQE + + +V N+ + + LE ++ +
Sbjct: 1253 IDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECI 1312
Query: 736 DSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQV 795
P + + + E G N S G++Q L +ARA+ R + +LD+ AA+D + +
Sbjct: 1313 AQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETI 1372
Query: 796 IGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELL 841
T + + H LH + +D I+VLA G + E + LL
Sbjct: 1373 ---REAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLL 1415
>gi|21729876 ATP-binding cassette, sub-family C, member 11 isoform b
[Homo sapiens]
Length = 1344
Score = 519 bits (1336), Expect = e-146
Identities = 402/1373 (29%), Positives = 631/1373 (45%), Gaps = 182/1373 (13%)
Query: 191 PFFPEDPQQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVS 250
PF P+ P+ P P A S T W++ L+ + R L + L ++S++ V
Sbjct: 73 PFRPK-PRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQ 131
Query: 251 RLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQV-FHS 309
RL + W S R+G KA LR + + R + A+ + F
Sbjct: 132 RLHRLWEEEVS------------RRGIE--KASVLLVMLRFQRT--RLIFDALLGICFCI 175
Query: 310 TFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQ 369
+LG + +I PK+L E +G+ G L +FLS C+++L
Sbjct: 176 ASVLGPILII---------PKILEYSEEQLGN----VVHGVGLCFALFLSECVKSLSFSS 222
Query: 370 NMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNG 429
+ + +R R+A++ + K++ S S G+ ++ + DV L E V Y
Sbjct: 223 SWIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPL 280
Query: 430 LWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISK---KRNHHQEEQMRQKDS 486
+ + +V+C + + ++G +A AI +L + PL F+++ K HH E D
Sbjct: 281 VLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEV---SDQ 337
Query: 487 RARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLV 546
R R+TS +L K IK + WE F + +R +E L GL+ S++ ++ + +
Sbjct: 338 RIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVA 397
Query: 547 ALVVFAVHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLC 606
V +HT + + + A AF L LN+L + F+P ++ L ++ + R F
Sbjct: 398 TAVWVLIHTSL-KLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFF- 455
Query: 607 LEEVDPGVVDSSSSGSAAGKDCITIHSATFAWSQESP----------------------- 643
L+E V + S A + AT +W Q P
Sbjct: 456 LQESPVFYVQTLQDPSKA----LVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPR 511
Query: 644 -------------PCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIE 690
P LH+INL V +G +L V G G+GKSSLLSA+L E+ +EG V ++
Sbjct: 512 DALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQ 571
Query: 691 GAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQG 750
G++AYVPQ+AW+ + ++ EN+ G D +VL C+L D++ P G T IGE+G
Sbjct: 572 GSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERG 631
Query: 751 MNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILV 810
+NLSGGQKQR+SLARAVY +YLLDDPL+A+DAHVG+H+F + I L+G T +LV
Sbjct: 632 LNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKK--TLRGKTVVLV 689
Query: 811 THALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQARQPGDRGEGETEPGTS 870
TH L L II+L NG I E G++ EL+Q+KG L+ + + + +
Sbjct: 690 THQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEA-TSDMLQDTAKI 748
Query: 871 TKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRV 930
+ P+ S L + +VPE T E E G +
Sbjct: 749 AEKPKVESQALATSLEESLNGNAVPEHQLTQEEEMEE--------------------GSL 788
Query: 931 KATVHLAYLRAVGTPLCLYALFLFLCQQV-ASFCRGYWLSLW------------------ 971
V+ Y++A G + +F F+ V + +WLS W
Sbjct: 789 SWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMA 848
Query: 972 -----ADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLW 1026
AD+P + Q L + +G + G+F + +AS L +L
Sbjct: 849 DLGNIADNPQLSFYQLVYGLNALLLICVGVCSS-GIFTKVT------RKASTALHNKLFN 901
Query: 1027 DVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATP- 1085
V R P+SFF+ PIG LLN F+ + + +D +P L+ + ++ V L+V+V +P
Sbjct: 902 KVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPY 961
Query: 1086 ---LATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRT 1142
+ + ++ F+ Y F+ V +RLE+ S S + SH+ + QG + + +
Sbjct: 962 ILLMGAIIMVICFIYYMMFKKAIGV----FKRLENYSRSPLFSHILNSLQGLSSIHVYGK 1017
Query: 1143 QAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLV 1202
F++Q D L + RW+A +E++ N + A A +
Sbjct: 1018 TEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFK 1077
Query: 1203 GFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDY-AWTPKEAPWRLPTCAAQPPWPQ 1261
+V+ LQ+ + Q R + E +VER+ Y EAP + + WPQ
Sbjct: 1078 VMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQ 1137
Query: 1262 GGQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEG 1321
G+I F+D+ ++YR P + G++ I E VGIVGRTG+GKSSL L RL E G
Sbjct: 1138 HGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197
Query: 1322 GIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLK 1381
I IDGV I +GL LRS++S+IPQDP+L G++R NLD H+D+ IW ALE
Sbjct: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALE----- 1252
Query: 1382 ALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQ 1441
R L K I+++DEATA++D T+ +Q
Sbjct: 1253 --------------------------------RTFLTKA-IILIDEATASIDMETDTLIQ 1279
Query: 1442 AMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFY 1494
+ F CTVL+IAHR+ +V++C +LVM G+V E P L + G +
Sbjct: 1280 RTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLF 1332
Score = 92.4 bits (228), Expect = 3e-18
Identities = 57/216 (26%), Positives = 109/216 (50%), Gaps = 14/216 (6%)
Query: 1285 VSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISI 1344
++ + G +G+ G TG+GKSSL S +L EG + + G ++
Sbjct: 530 INLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------SLAY 576
Query: 1345 IPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSV 1404
+PQ + G++R N+ + + L L + LP + +RG +LS
Sbjct: 577 VPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSG 636
Query: 1405 GQKQLLCLARALLRKTQILILDEATAAVDPGTELQM-QAMLGSWFAQCTVLLIAHRLRSV 1463
GQKQ + LARA+ QI +LD+ +AVD + + + TV+L+ H+L+ +
Sbjct: 637 GQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYL 696
Query: 1464 MDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQE 1499
C ++++++ G++ E+G+ ++L+ +KG + +L Q+
Sbjct: 697 EFCGQIILLENGKICENGTHSELMQKKGKYAQLIQK 732
Score = 63.2 bits (152), Expect = 2e-09
Identities = 98/479 (20%), Positives = 193/479 (40%), Gaps = 46/479 (9%)
Query: 383 SAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFV 442
+A+ ++ KV +G ++N + D+++L + + + +L L +V+ +
Sbjct: 893 TALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVL 952
Query: 443 YLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSK--- 499
+ +L P L A+ + + + + + KK + + SR+ L S IL + +
Sbjct: 953 LIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRL--ENYSRSPLFSHILNSLQGLS 1010
Query: 500 TIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSL----VSFQVSTFLVALVVFAVHT 555
+I +G F+ + + + L LLF S + ++ T LV L V
Sbjct: 1011 SIHVYGKTEDFISQFKRLTDAQNNYL----LLFLSSTRWMALRLEIMTNLVTLAVALFVA 1066
Query: 556 LVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFL--CLEEVDPG 613
+ + K VL + + QA + + Q + +R++ ++ C+ E
Sbjct: 1067 FGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQF-TAVERILQYMKMCVSEAPLH 1125
Query: 614 VVDSSSSGSAAGKDCITIHSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLL 673
+ +S I + +P LH INLT+ ++ +VG G+GKSSL
Sbjct: 1126 MEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLG 1185
Query: 674 SALLGELSKVEGFVSIEGA-VAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQ 732
AL + + G + I+G + + E SV+ DP VL + ++
Sbjct: 1186 MALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQ-------DP-----VLLSGTIR 1233
Query: 733 PDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVF 792
++D F I + +L R KA + L+D+ A++D +
Sbjct: 1234 FNLDPFDRHTDQQIWD-------------ALERTFLTKAII-LIDEATASIDMETDTLIQ 1279
Query: 793 NQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLL 851
+ QG T +++ H + + D I+V+ NG + E + L ++ G+L L
Sbjct: 1280 RTI---REAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAAL 1335
>gi|221316556 ATP-binding cassette, sub-family C, member 3 isoform 2
[Homo sapiens]
Length = 572
Score = 369 bits (946), Expect = e-101
Identities = 210/543 (38%), Positives = 300/543 (55%), Gaps = 9/543 (1%)
Query: 10 GQGVWNQTEPEPAATSLLSLCFLRTAGVWVPPMYLWVLGPIYLLFIHHHGRGYLRMSPLF 69
G W+ L+ CF + WVP +YLWV P YLL++ HH RGY+ +S L
Sbjct: 11 GSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHCRGYIILSHLS 70
Query: 70 KAKMVLGFALIVLCTSSVAVALWKIQQGTPEAPEFLIHPTVWLTTMSFAVFLIHTERKKG 129
K KMVLG L + + + + + G AP F + P V TM A LI ER +G
Sbjct: 71 KLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYERLQG 130
Query: 130 VQSSGVLFGYWLLCFV---LPATNAAQQASGAGFQSDPVRHLSTYLCLSLVVAQFVLSCL 186
VQSSGVL +W LC V +P + A G SDP R + Y+ +LV++ +L+C
Sbjct: 131 VQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALILACF 190
Query: 187 ADQPPFFPEDPQQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSE 246
++PPFF NP PET A F S+ FWW + + GYR PL KDLWSL E+ S+
Sbjct: 191 REKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQ 250
Query: 247 ELVSRLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRP-LLKAIWQ 305
+V +L + W + RH KA A K SG E E L +P LKA+
Sbjct: 251 MVVQQLLEAWRKQEKQTARH-KASAAPGKNASG----EDEVLLGARPRPRKPSFLKALLA 305
Query: 306 VFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTL 365
F S+FL+ +I D+ F P+LLS+ + FI +P P+W G+L+A LMFL + +Q+L
Sbjct: 306 TFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSL 365
Query: 366 FEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVL 425
Q + + V ++ R+ I G++YRK L +++ ++AS VG++VNL+SVD QR +
Sbjct: 366 ILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAP 425
Query: 426 YLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKD 485
+LN LW + I++ +LWQ LGPS L +A + L+PLN ++ K Q +QM+ KD
Sbjct: 426 FLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKD 485
Query: 486 SRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFL 545
SR +L S IL K +K + WE +FL +V GIR EL LRT+ L + + ++ S FL
Sbjct: 486 SRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFL 545
Query: 546 VAL 548
V L
Sbjct: 546 VRL 548
>gi|157502203 ATP-binding cassette, sub-family C, member 4 isoform 2
[Homo sapiens]
Length = 859
Score = 362 bits (928), Expect = 2e-99
Identities = 260/886 (29%), Positives = 434/886 (48%), Gaps = 77/886 (8%)
Query: 198 QQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWM 257
Q+ P P A S+ FWW++ L G++R L D++S+ E+ S+ L L+ W
Sbjct: 6 QEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFW- 64
Query: 258 RNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLS 317
++ R N A Q+ S R ++K W+ S +LG +
Sbjct: 65 -DKEVLRAENDA---------------------QKPSLTRAIIKCYWK---SYLVLGIFT 99
Query: 318 LI------ISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNM 371
LI I +F + K+++ F + Y A ++ + +
Sbjct: 100 LIEESAKVIQPIF---LGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYF 156
Query: 372 YRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLW 431
Y ++ MRLR A+ ++YRK L LS+ + + G +VNL+S DV + + ++L+ LW
Sbjct: 157 YHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLW 216
Query: 432 LPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLT 491
+ + LW +G S L +AV + LLPL K + + + D+R R
Sbjct: 217 AGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTM 276
Query: 492 SSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVF 551
+ ++ + IK + WE +F + + +R +E+ + S L ++L SF ++ ++ V F
Sbjct: 277 NEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTF 336
Query: 552 AVHTLVAENAMNAEKAFVTLTVLNILN-KAQAFLPFSIHSLVQARVSFDRLVTFLCLEEV 610
+ L+ + + A + FV +T+ + F P +I + +A VS R+ TFL L+E+
Sbjct: 337 TTYVLLG-SVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEI 395
Query: 611 DPGVVDSSSSGSAAGKDCITIHSATFAWSQESP-PCLHRINLTVPQGCLLAVVGPVGAGK 669
+ + GK + + T W + S P L ++ TV G LLAVVGPVGAGK
Sbjct: 396 S----QRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGK 451
Query: 670 SSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEAC 729
SSLLSA+LGEL+ G VS+ G +AYV Q+ WV + ++ N+ FG++ + E+V++AC
Sbjct: 452 SSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKAC 511
Query: 730 ALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQ 789
AL+ D+ +G T IG++G LSGGQK R++LARAVY+ A +YLLDDPL+A+DA V +
Sbjct: 512 ALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSR 571
Query: 790 HVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVC 849
H+F I +L ILVTH L L A I++L +G + + G+Y E L+
Sbjct: 572 HLFELCICQ--ILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGS 629
Query: 850 LLDQARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVP 909
LL ++ + E PGT P LR +S +++ + +
Sbjct: 630 LL---KKDNEESEQPPVPGT-------------PTLRNRTFSESSVWSQQSSRPSLKDGA 673
Query: 910 LDDPDRAGWPA--GKDSIQYGRVKATVHLAYLRA-VGTPLCLYALFLFLCQQVASFCRGY 966
L+ D P +++ G+V + Y RA + ++ + L QVA + +
Sbjct: 674 LESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDW 733
Query: 967 WLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFA--SMAAVLLGGAR--------- 1015
WLS WA+ ++ G + L +G+++ ++A VL G AR
Sbjct: 734 WLSYWANKQSMLNVTVNGG--GNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLV 791
Query: 1016 -ASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIP 1060
+S+ L ++ ++++P+ FF+R PIG +LNRFSK+ +D +P
Sbjct: 792 NSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLP 837
Score = 89.4 bits (220), Expect = 2e-17
Identities = 104/456 (22%), Positives = 197/456 (43%), Gaps = 28/456 (6%)
Query: 1038 RTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLL 1097
+T G ++N S + + D + L L + V+ ++ + ++ +A + + ++
Sbjct: 188 KTTTGQIVNLLSNDVNKFD-QVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLII 246
Query: 1098 YAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQ-NNARVDE 1156
QS + LR + + M E G +++ + + F N R E
Sbjct: 247 LLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKE 306
Query: 1157 SQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVS--AALQVTQ 1214
+I + LA+ +VF T VL + ++A V +V+ A+++T
Sbjct: 307 ISKILRSSCLRGMNLASFFSA-SKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTV 365
Query: 1215 TLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEFRDFGLRY 1274
TL + + +IVS+ R+Q + + + Q P + +DF +
Sbjct: 366 TL-FFPSAIERVSEAIVSIRRIQTFLLLDE-----ISQRNRQLPSDGKKMVHVQDFTAFW 419
Query: 1275 --RPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAH 1332
E P +QG+SF + GE + +VG GAGKSSL S +L G
Sbjct: 420 DKASETP-TLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVL-------------GELAPS 465
Query: 1333 VGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQ 1392
GL ++ RI+ + Q P +F G+LR N+ +++ E ++ LK + L
Sbjct: 466 HGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDL 525
Query: 1393 YKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQM-QAMLGSWFAQC 1451
DRG LS GQK + LARA+ + I +LD+ +AVD + + + +
Sbjct: 526 TVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEK 585
Query: 1452 TVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLL 1487
+L+ H+L+ + +++L++ G++ + G+ + L
Sbjct: 586 ITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFL 621
>gi|90421313 cystic fibrosis transmembrane conductance regulator [Homo
sapiens]
Length = 1480
Score = 252 bits (644), Expect = 2e-66
Identities = 163/533 (30%), Positives = 272/533 (51%), Gaps = 27/533 (5%)
Query: 992 GLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKE 1051
G+ L A+G F + V S++L ++L V+++P+S G +LNRFSK+
Sbjct: 921 GVADTLLAMGFFRGLPLVHTL-ITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKD 979
Query: 1052 TDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQ 1111
+D +P + + ++ VVAV P VA +P+ + + ++ ++ +S Q
Sbjct: 980 IAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQ 1039
Query: 1112 LRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWL 1171
L++LES S + +H+ + +G +RAF Q F + ++ F L RW
Sbjct: 1040 LKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWF 1099
Query: 1172 AANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIV 1231
+E++ A ++L+ G VG ++ A+ + TLQW V + D+++ +
Sbjct: 1100 QMRIEMIFVIFFIAVTFISILTTGE-GEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMR 1158
Query: 1232 SVERMQDYAWTPKEAPWRLPTCAAQPP---------------------WPQGGQIEFRDF 1270
SV R+ + P E PT + +P WP GGQ+ +D
Sbjct: 1159 SVSRVFKFIDMPTEGK---PTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDL 1215
Query: 1271 GLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPI 1330
+Y ++ +SF I G++VG++GRTG+GKS+L S LRL EG I IDGV
Sbjct: 1216 TAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNT-EGEIQIDGVSW 1274
Query: 1331 AHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQ 1390
+ L R +IPQ +F G+ R NLD ++ SD+ IW + V L++++ PG+
Sbjct: 1275 DSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGK 1334
Query: 1391 LQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQ 1450
L + D G LS G KQL+CLAR++L K +IL+LDE +A +DP T ++ L FA
Sbjct: 1335 LDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFAD 1394
Query: 1451 CTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQESGLV 1503
CTV+L HR+ ++++C + LV+++ +V + S +LL ++ LF + S V
Sbjct: 1395 CTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRV 1447
Score = 219 bits (558), Expect = 2e-56
Identities = 166/671 (24%), Positives = 308/671 (45%), Gaps = 76/671 (11%)
Query: 204 PETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRSAA 263
P A+ SK F W ++ +GYR+ L D++ + +S++ L +LE+EW R A+
Sbjct: 5 PLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDREL-AS 63
Query: 264 RRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIISDV 323
+++ K L+ A+ + F F+ + L + +V
Sbjct: 64 KKNPK------------------------------LINALRRCFFWRFMFYGIFLYLGEV 93
Query: 324 FRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACL----QTLFEQQNMYRLKVLQM 379
+ P LL I P + +A+ + + CL +TL ++ L + M
Sbjct: 94 TKAVQPLLLG---RIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGM 150
Query: 380 RLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVV 439
++R A+ L+Y+K L LSS ++G +V+L+S ++ + E + + +W+ + + +
Sbjct: 151 QMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVAL 210
Query: 440 CFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSK 499
+W+LL SA + + L + + +++++ + R +TS ++ N +
Sbjct: 211 LMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQ 270
Query: 500 TIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAE 559
++K + WE A + +R EL R + + + +F S F V + + L+
Sbjct: 271 SVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALI-- 328
Query: 560 NAMNAEKAFVTLTVLNILNKAQAF-LPFSIHSLVQARVSFDRLVTFLCLEEV-------- 610
+ K F T++ +L A P+++ + + + +++ FL +E
Sbjct: 329 KGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLT 388
Query: 611 ---------------------DPGVVDSSSSGSAAGKDCITIHSATFAWSQESPPCLHRI 649
+ ++++ ++ G D + + +S P L I
Sbjct: 389 TTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSN----FSLLGTPVLKDI 444
Query: 650 NLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVE 709
N + +G LLAV G GAGK+SLL ++GEL EG + G +++ Q +W+ ++ E
Sbjct: 445 NFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKE 504
Query: 710 NVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYR 769
N+ FG D V++AC L+ D+ F E + +GE G+ LSGGQ+ R+SLARAVY+
Sbjct: 505 NIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYK 564
Query: 770 KAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANG 829
A +YLLD P LD + +F + L+ TRILVT + L +AD I++L G
Sbjct: 565 DADLYLLDSPFGYLDVLTEKEIFESCVCK--LMANKTRILVTSKMEHLKKADKILILHEG 622
Query: 830 AIAEMGSYQEL 840
+ G++ EL
Sbjct: 623 SSYFYGTFSEL 633
Score = 79.3 bits (194), Expect = 3e-14
Identities = 63/245 (25%), Positives = 113/245 (46%), Gaps = 21/245 (8%)
Query: 629 ITIHSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVS 688
+T+ T +++ L I+ ++ G + ++G G+GKS+LLSA L L EG +
Sbjct: 1210 MTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFL-RLLNTEGEIQ 1268
Query: 689 IEG-------------AVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDV 735
I+G A +PQ+ ++ + + +N+ ++ + +V + L+ +
Sbjct: 1269 IDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVI 1328
Query: 736 DSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQV 795
+ FP + + + G LS G KQ + LAR+V KA + LLD+P A LD V + +
Sbjct: 1329 EQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDP-VTYQIIRRT 1387
Query: 796 IGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQAR 855
+ T IL H + + + +V+ + + S Q+LL + L QA
Sbjct: 1388 LKQA--FADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERS----LFRQAI 1441
Query: 856 QPGDR 860
P DR
Sbjct: 1442 SPSDR 1446
Score = 70.1 bits (170), Expect = 2e-11
Identities = 68/314 (21%), Positives = 133/314 (42%), Gaps = 49/314 (15%)
Query: 1202 VGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTP--KEAPWRLPTCAAQPP- 1258
+ F + + VT+ W V+ W D S+ ++ ++QD+ K + L T
Sbjct: 340 ISFCIVLRMAVTRQFPWAVQTWYD---SLGAINKIQDFLQKQEYKTLEYNLTTTEVVMEN 396
Query: 1259 ----WPQG---------------------GQIEFRDFGLRYRPELPLAVQGVSFKIHAGE 1293
W +G + F +F L P L + ++FKI G+
Sbjct: 397 VTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVL----KDINFKIERGQ 452
Query: 1294 KVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFP 1353
+ + G TGAGK+SL ++ E +EG I H G RIS Q + P
Sbjct: 453 LLAVAGSTGAGKTSLLMVIMGELEPSEG-------KIKHSG------RISFCSQFSWIMP 499
Query: 1354 GSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLA 1413
G+++ N+ + + + ++ QL+ ++ + + G LS GQ+ + LA
Sbjct: 500 GTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLA 559
Query: 1414 RALLRKTQILILDEATAAVDPGTELQM-QAMLGSWFAQCTVLLIAHRLRSVMDCARVLVM 1472
RA+ + + +LD +D TE ++ ++ + A T +L+ ++ + ++L++
Sbjct: 560 RAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILIL 619
Query: 1473 DKGQVAESGSPAQL 1486
+G G+ ++L
Sbjct: 620 HEGSSYFYGTFSEL 633
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 228 bits (581), Expect = 3e-59
Identities = 238/911 (26%), Positives = 403/911 (44%), Gaps = 96/911 (10%)
Query: 639 SQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGA------ 692
S++ L +NL V G +A+VG G GKS+ + + EG VS++G
Sbjct: 403 SRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTIN 462
Query: 693 -------VAYVPQEAWVQNTSVVENVCFGQE-LDPPWLERVLEACALQPDVDSFPEGIHT 744
+ V QE + T++ EN+ +G+E + +E+ ++ + P T
Sbjct: 463 VRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDT 522
Query: 745 SIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQG 804
+GE+G LSGGQKQR+++ARA+ R + LLD+ +ALD V + +G
Sbjct: 523 LVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVV---QVALDKARKG 579
Query: 805 TTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLD--------QARQ 856
T I++ H L + AD I +G I E G++ EL++ KG L+ +
Sbjct: 580 RTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELEN 639
Query: 857 PGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDD--PD 914
D + E + + + +S R+ RR S++ +DR S T+ LD+ P
Sbjct: 640 AADESKSEIDALEMSSNDSRSSLIRKRSTRR--SVRGSQAQDRKLS---TKEALDESIPP 694
Query: 915 RAGWPAGKDSI-QYGRVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLWAD 973
+ W K ++ ++ V A + P A + + + F R D
Sbjct: 695 VSFWRIMKLNLTEWPYFVVGVFCAIINGGLQP----AFAIIFSKIIGVFTR-------ID 743
Query: 974 DPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGA--RASRLLFQRLLWDVVRS 1031
DP Q + +F LL A+G+ + + L G +A +L +RL + V RS
Sbjct: 744 DPETKRQNSN------LFSLL--FLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRS 795
Query: 1032 ----PISFFE--RTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGL---LEVSLVVAV 1082
+S+F+ + G L R + + V I +L + L + +S +
Sbjct: 796 MLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGW 855
Query: 1083 ATPLATVAILPLFLLYAGFQSLYVVSSCQLR-RLESASYSSVCSHMAETFQGSTVVR--- 1138
L +AI+P+ + AG + ++S L+ + E + + E F+ TVV
Sbjct: 856 QLTLLLLAIVPIIAI-AGVVEMKMLSGQALKDKKELEGSGKIATEAIENFR--TVVSLTQ 912
Query: 1139 --------AFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCA 1190
A Q P+ +N+ R I+F A + + G A
Sbjct: 913 EQKFEHMYAQSLQVPY--RNSLRKAHIFGITFSFTQAMMYFSY-AGCFRFGAYLVAHKLM 969
Query: 1191 VLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRL 1250
L V F A QV+ + + I+ +E+ TP +
Sbjct: 970 SFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEK------TPLIDSY-- 1021
Query: 1251 PTCAAQPPWPQGGQIEFRDFGLRY--RPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSL 1308
+ P G + F + Y RP++P+ +QG+S ++ G+ + +VG +G GKS++
Sbjct: 1022 -STEGLMPNTLEGNVTFGEVVFNYPTRPDIPV-LQGLSLEVKKGQTLALVGSSGCGKSTV 1079
Query: 1309 ASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNL---DLLQE 1365
L R + G + +DG I + + LR+ + I+ Q+PILF S+ N+ D +
Sbjct: 1080 VQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRV 1139
Query: 1366 HSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILIL 1425
S E I A + + A + SLP + K D+G LS GQKQ + +ARAL+R+ IL+L
Sbjct: 1140 VSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLL 1199
Query: 1426 DEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQ 1485
DEAT+A+D +E +Q L T ++IAHRL ++ + ++V G+V E G+ Q
Sbjct: 1200 DEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQ 1259
Query: 1486 LLAQKGLFYRL 1496
LLAQKG+++ +
Sbjct: 1260 LLAQKGIYFSM 1270
Score = 142 bits (358), Expect = 2e-33
Identities = 126/516 (24%), Positives = 237/516 (45%), Gaps = 24/516 (4%)
Query: 994 LGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETD 1053
+G + + ++ L R + ++ ++R I +F+ +G L R + +
Sbjct: 121 IGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVS 180
Query: 1054 TVDVDIPDKL----RSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSS 1109
++ I DK+ +S+ + G + V L +AI P+ L A + + S
Sbjct: 181 KINEGIGDKIGMFFQSMATFFTGFI-VGFTRGWKLTLVILAISPVLGLSAAVWAKILSSF 239
Query: 1110 CQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADR 1169
L A +V E V AF Q + + N ++E++RI + +
Sbjct: 240 TDKELLAYAKAGAVAE---EVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAIT-- 294
Query: 1170 WLAANVELLGNGLVFAAATCAVLSKAHLSAGLVG-FSVSAALQVTQTLQWVVRNWTDLEN 1228
AN+ + G + A+ A+ + L G +S+ L V ++ +
Sbjct: 295 ---ANISI-GAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASP 350
Query: 1229 SIVSVERMQDYAWTPKEAPWRLPTC-----AAQPPWPQGGQIEFRDFGLRY--RPELPLA 1281
SI + + A+ + P+ + P G +EFR+ Y R E+ +
Sbjct: 351 SIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKI- 409
Query: 1282 VQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSR 1341
++G++ K+ +G+ V +VG +G GKS+ + RL + EG + +DG I + + LR
Sbjct: 410 LKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREI 469
Query: 1342 ISIIPQDPILFPGSLRMNLDLLQEH-SDEAIWAALETVQLKALVASLPGQLQYKCADRGE 1400
I ++ Q+P+LF ++ N+ +E+ + + I A++ + LP + +RG
Sbjct: 470 IGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGA 529
Query: 1401 DLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRL 1460
LS GQKQ + +ARAL+R +IL+LDEAT+A+D +E +Q L T ++IAHRL
Sbjct: 530 QLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRL 589
Query: 1461 RSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRL 1496
+V + + D G + E G+ +L+ +KG++++L
Sbjct: 590 STVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKL 625
>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
[Homo sapiens]
Length = 1321
Score = 221 bits (564), Expect = 3e-57
Identities = 283/1207 (23%), Positives = 510/1207 (42%), Gaps = 172/1207 (14%)
Query: 390 YRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFVYL----- 444
+R+++ + G ++VG++ S D+ ++ +++ L++ + +C L
Sbjct: 179 FRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRG 238
Query: 445 WQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFH 504
W+L + + + + +SK ++ +++ + ++ + +T+
Sbjct: 239 WKLTLVIISVSPLIGIGAATIGLSVSKFTDY----ELKAYAKAGVVADEVISSMRTVAAF 294
Query: 505 GWEGAFLDRVLG--IRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAM 562
G E ++R + Q G + + F V + + AL + TLV +
Sbjct: 295 GGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFV-WCLIFLCYALAFWYGSTLVLDEGE 353
Query: 563 NAEKAFVTLTV------LNILNKAQAFLPFSIHSLVQARV--SFDRLVTFLCLEEVDPGV 614
V + + LN+ N + F+ + + DR C+ E
Sbjct: 354 YTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSE----- 408
Query: 615 VDSSSSGSAAGKDCITIHSATFAW-SQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLL 673
D G+ I H+ TF + S+ L+ +N+ + G + A+VGP GAGKS+ L
Sbjct: 409 -DGYKLDRIKGE--IEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTAL 465
Query: 674 SALLGELSKVEGFVSIEG-------------AVAYVPQEAWVQNTSVVENVCFGQELDPP 720
+ EG V+++G + V QE + +T++ EN+ +G+E
Sbjct: 466 QLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGRE--DA 523
Query: 721 WLERVLEACALQPDVDSF----PEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLL 776
+E +++A A + + +F P+ T +GE G +SGGQKQR+++ARA+ R + LL
Sbjct: 524 TMEDIVQA-AKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLL 582
Query: 777 DDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGS 836
D +ALD + + + +V+ + G T I V H L + AD II +G E G+
Sbjct: 583 DMATSALD-NESEAMVQEVLSK--IQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGT 639
Query: 837 YQELLQRKGALVCLLDQARQPGDRGEGETEPGTSTKDP-------RGTSAGRRPELRRER 889
++ELL+RKG L+ Q G++ E + +T+D RG+ R+R
Sbjct: 640 HEELLERKGVYFTLVTLQSQ-GNQALNEEDIKDATEDDMLARTFSRGSYQDSLRASIRQR 698
Query: 890 SI-----------------KSVPEKDRTTSEAQTEVPLDDP--------DRAGWPAGKDS 924
S KS E+DR + + ++ WP
Sbjct: 699 SKSQLSYLVHEPPLAVVDHKSTYEEDRKDKDIPVQEEVEPAPVRRILKFSAPEWPY---- 754
Query: 925 IQYGRVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLWADDPAVGGQQTQA 984
+ G V A V+ GT LYA FLF Q + +F ++ ++ Q
Sbjct: 755 MLVGSVGAAVN-------GTVTPLYA-FLF-SQILGTF-------------SIPDKEEQR 792
Query: 985 ALRGGI---FGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFE--RT 1039
+ G+ F +GC+ F A G ++ L + ++ I++F+ R
Sbjct: 793 SQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRN 852
Query: 1040 PIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVA----TPLATVAILPLF 1095
G L R + + V ++ +++ +F + V++++A + L + P F
Sbjct: 853 SPGALTTRLATDASQVQGAAGSQI-GMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFP-F 910
Query: 1096 LLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVD 1155
L +G +++ R + + V E V + F+ ++
Sbjct: 911 LALSGATQTRMLTGFASR--DKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELE 968
Query: 1156 ESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAA----LQ 1211
+ + + + AN+ G FA A C + S G+ +S
Sbjct: 969 KPFKTAIQK--------ANIY----GFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSY 1016
Query: 1212 VTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCA------AQPP------- 1258
V + + VV + T L + +++TP A ++ QPP
Sbjct: 1017 VFRVISAVVLSATALGRA---------FSYTPSYAKAKISAARFFQLLDRQPPISVYNTA 1067
Query: 1259 ---WPQ-GGQIEFRDFGLRY--RPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGL 1312
W G+I+F D Y RP+ + + G+S I G+ + VG +G GKS+ L
Sbjct: 1068 GEKWDNFQGKIDFVDCKFTYPSRPDSQV-LNGLSVSISPGQTLAFVGSSGCGKSTSIQLL 1126
Query: 1313 LRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNL---DLLQEHSDE 1369
R + +G + IDG V + LRS I I+ Q+P+LF S+ N+ D +E E
Sbjct: 1127 ERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPME 1186
Query: 1370 AIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEAT 1429
+ AA + QL V SLP + + +G LS G+KQ + +ARA++R +IL+LDEAT
Sbjct: 1187 RVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEAT 1246
Query: 1430 AAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQ 1489
+A+D +E +Q L T ++IAHRL ++ + + VM +G V E G+ +L+AQ
Sbjct: 1247 SALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQ 1306
Query: 1490 KGLFYRL 1496
KG +Y+L
Sbjct: 1307 KGAYYKL 1313
>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
sapiens]
Length = 738
Score = 164 bits (414), Expect = 8e-40
Identities = 141/500 (28%), Positives = 242/500 (48%), Gaps = 29/500 (5%)
Query: 1013 GARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETD----TVDVDIPDKLRSLLM 1068
G R L L ++R ++FF++T G L+NR S +T +V ++ D LR+
Sbjct: 240 GQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQ 299
Query: 1069 YAFGLLEVSLVVAVATPLAT--VAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVC-- 1124
+ G +S++ V+ LAT ++++P + A Y LR+L + S+
Sbjct: 300 ASVG---ISMMFFVSPNLATFVLSVVPPVSIIAVIYGRY------LRKLTKVTQDSLAQA 350
Query: 1125 SHMAETFQGST-VVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLV 1183
+ +AE G+ VRAF + + + ++VD +++ A L GN +V
Sbjct: 351 TQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIV 410
Query: 1184 FAAATCA--VLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAW 1241
+ ++ AH++ G + + A V ++ + +++L + + R+ +
Sbjct: 411 LSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLE 470
Query: 1242 TPKEAPWRLPTCAAQPPWPQGGQIEFRDFGLRY--RPELPLAVQGVSFKIHAGEKVGIVG 1299
+ P+ + + G +EF++ Y RPE+P+ Q S I +G +VG
Sbjct: 471 REPKLPFNEGVILNEKSFQ--GALEFKNVHFAYPARPEVPI-FQDFSLSIPSGSVTALVG 527
Query: 1300 RTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMN 1359
+G+GKS++ S LLRL + A G I +DG I + LRS+I + Q+PILF S+ N
Sbjct: 528 PSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAEN 587
Query: 1360 L----DLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARA 1415
+ D + E I E A + + P ++G LS GQKQ + +ARA
Sbjct: 588 IAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARA 647
Query: 1416 LLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKG 1475
LL+ +IL+LDEAT+A+D E +Q L TVL+IAHRL ++ + V V+D+G
Sbjct: 648 LLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQG 707
Query: 1476 QVAESGSPAQLLAQKGLFYR 1495
++ E G +LL++ YR
Sbjct: 708 KITEYGKHEELLSKPNGIYR 727
Score = 120 bits (300), Expect = 1e-26
Identities = 71/222 (31%), Positives = 122/222 (54%), Gaps = 22/222 (9%)
Query: 644 PCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEG------------ 691
P +L++P G + A+VGP G+GKS++LS LL G +S++G
Sbjct: 508 PIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLR 567
Query: 692 -AVAYVPQEAWVQNTSVVENVCFGQELDPPW-----LERVLEACALQPDVDSFPEGIHTS 745
+ V QE + + S+ EN+ +G + DP ++RV E + +FP+G +T
Sbjct: 568 SKIGTVSQEPILFSCSIAENIAYGAD-DPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTV 626
Query: 746 IGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGT 805
+GE+G+ LSGGQKQR+++ARA+ + + LLD+ +ALDA +++ + + L+ G
Sbjct: 627 VGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAE-NEYLVQEAL--DRLMDGR 683
Query: 806 TRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGAL 847
T +++ H L + A+ + VL G I E G ++ELL + +
Sbjct: 684 TVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGI 725
>gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Homo
sapiens]
Length = 808
Score = 162 bits (410), Expect = 2e-39
Identities = 136/485 (28%), Positives = 242/485 (49%), Gaps = 25/485 (5%)
Query: 1028 VVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMY---AFGLLEVSLVVAVAT 1084
V+R FF++ G++++R +++T T+ + + L L Y LL + L +V+
Sbjct: 328 VLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVSL 387
Query: 1085 PLATVAILPL-FLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQ 1143
+ T+ LPL FLL Y + Q+R ES + SS + E VR+F +
Sbjct: 388 TMVTLITLPLLFLLPKKVGKWYQLLEVQVR--ESLAKSSQVA--IEALSAMPTVRSFANE 443
Query: 1144 APFVAQNNARVDESQRISFPRLVA---DRWLAA-NVELLGNGLVFAAATCAVLSKAHLSA 1199
+ ++ E + ++ VA + W + + LL G+++ V S A S
Sbjct: 444 EGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQL-VTSGAVSSG 502
Query: 1200 GLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPW 1259
LV F V +Q TQ ++ ++ + ++ ++ S E++ +Y + R P P
Sbjct: 503 NLVTF-VLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYL----DRTPRCPPSGLLTPL 557
Query: 1260 PQGGQIEFRDFGLRY--RPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQE 1317
G ++F+D Y RP++ L +QG++F + GE +VG G+GKS++A+ L L +
Sbjct: 558 HLEGLVQFQDVSFAYPNRPDV-LVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQ 616
Query: 1318 AAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNL--DLLQEHSDEAIWAAL 1375
G + +DG P+ L +++ + Q+P +F SL+ N+ L Q+ + E I AA
Sbjct: 617 PTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAA 676
Query: 1376 ETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPG 1435
+ ++ LP + + G LS GQ+Q + LARAL+RK +LILD+AT+A+D
Sbjct: 677 VKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDAN 736
Query: 1436 TELQMQAML--GSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLF 1493
++LQ++ +L +VLLI L V +L ++ G + E G+ QL+ +KG +
Sbjct: 737 SQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCY 796
Query: 1494 YRLAQ 1498
+ + Q
Sbjct: 797 WAMVQ 801
Score = 117 bits (293), Expect = 8e-26
Identities = 136/540 (25%), Positives = 249/540 (46%), Gaps = 49/540 (9%)
Query: 351 LLAVLMFLSACLQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVV 410
L+++L SA L+ F +Y + + S + G V+ VL + + + G+++
Sbjct: 290 LMSILTIASAVLE--FVGDGIYNNTM--GHVHSHLQGEVFGAVLRQETEFFQQNQTGNIM 345
Query: 411 NLVSVDVQRLTESVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFIS 470
+ V+ D L++S+ L+L W +V + L ++ +++ V L LPL F +
Sbjct: 346 SRVTEDTSTLSDSLSENLSLFL---WYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLP 402
Query: 471 KKRNH-HQEEQMRQKDSRARLTS---SILRNSKTIK-FHGWEGA---FLDRVLGIRGQEL 522
KK +Q +++ ++S A+ + L T++ F EG F +++ QE+
Sbjct: 403 KKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKL-----QEI 457
Query: 523 GAL-RTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAMNAEKAFVTLTVLNILNKAQ 581
L + + ++V+ + +S L+ + + + + + + VT + +
Sbjct: 458 KTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQA 517
Query: 582 AFLPFSIHSLVQARV-SFDRLVTFLCLEEVDPGVVDSSSSGSAAGKDCITIHSATFAW-S 639
+ SI+ VQ V S +++ +L + P S + + +FA+ +
Sbjct: 518 VEVLLSIYPRVQKAVGSSEKIFEYL---DRTPRCPPSGLLTPLHLEGLVQFQDVSFAYPN 574
Query: 640 QESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGA------- 692
+ L + T+ G + A+VGP G+GKS++ + L G + ++G
Sbjct: 575 RPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEH 634
Query: 693 ------VAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSF----PEGI 742
VA V QE V S+ EN+ +G P E + A A++ SF P+G
Sbjct: 635 RYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEE--ITAAAVKSGAHSFISGLPQGY 692
Query: 743 HTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLL 802
T + E G LSGGQ+Q ++LARA+ RK V +LDD +ALDA+ Q Q++
Sbjct: 693 DTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDAN-SQLQVEQLLYESPER 751
Query: 803 QGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQARQPGDRGE 862
+ +L+T L ++ QAD I+ L GAI E G++Q+L+++KG C + P D E
Sbjct: 752 YSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKG---CYWAMVQAPADAPE 808
>gi|118582251 URG7 protein isoform 2 [Homo sapiens]
Length = 99
Score = 162 bits (409), Expect = 3e-39
Identities = 74/74 (100%), Positives = 74/74 (100%)
Query: 1 MAAPAEPCAGQGVWNQTEPEPAATSLLSLCFLRTAGVWVPPMYLWVLGPIYLLFIHHHGR 60
MAAPAEPCAGQGVWNQTEPEPAATSLLSLCFLRTAGVWVPPMYLWVLGPIYLLFIHHHGR
Sbjct: 1 MAAPAEPCAGQGVWNQTEPEPAATSLLSLCFLRTAGVWVPPMYLWVLGPIYLLFIHHHGR 60
Query: 61 GYLRMSPLFKAKMV 74
GYLRMSPLFKAKMV
Sbjct: 61 GYLRMSPLFKAKMV 74
>gi|73747915 transporter 2, ATP-binding cassette, sub-family B isoform
1 [Homo sapiens]
Length = 703
Score = 152 bits (385), Expect = 2e-36
Identities = 140/540 (25%), Positives = 262/540 (48%), Gaps = 37/540 (6%)
Query: 977 VGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGG------ARASRLLFQRLLWDVVR 1030
+GG A IF + CL + G +S++A GG +R + + ++L ++R
Sbjct: 180 LGGDFDPHAFASAIFFM--CLFSFG--SSLSAGCRGGCFTYTMSRINLRIREQLFSSLLR 235
Query: 1031 SPISFFERTPIGHLLNRFSKETDTVDVDIP---DKLRSLLMYAFGLLEVSLVVAVATPLA 1087
+ FF+ T G L +R S +T + +P + L L+ GL L ++ L
Sbjct: 236 QDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTLL 295
Query: 1088 TVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFV 1147
++ +P + + +Y ++ R + + + E G VR+F + V
Sbjct: 296 SLLHMPFTI---AAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEV 352
Query: 1148 AQNNARVDESQRISFPRLV--ADRWLAANVELLGNGLVFAAATCAVLSKAHLSAG-LVGF 1204
+ +++ +++ + R + A L V LG ++ + + L+ G L+ F
Sbjct: 353 CRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSF 412
Query: 1205 SVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWPQGGQ 1264
+ V +Q +V + D+ +++ + E++ Y + LP+ P G
Sbjct: 413 MIYQE-SVGSYVQTLVYIYGDMLSNVGAAEKVFSYM----DRQPNLPSPGTLAPTTLQGV 467
Query: 1265 IEFRDFGLRY--RPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGG 1322
++F+D Y RP+ P+ ++G++F + GE +VG G+GKS++A+ L L + G
Sbjct: 468 VKFQDVSFAYPNRPDRPV-LKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQ 526
Query: 1323 IWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDL-LQEHSDEAIWAALETVQLK 1381
+ +D PI+ L S++ + Q+P+LF GS+R N+ LQ D+ + AA +
Sbjct: 527 VLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHAD 586
Query: 1382 ALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQ 1441
+ + + ++G L+ GQKQ L +ARAL+R ++LILDEAT+A+D +Q +
Sbjct: 587 DFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALD----VQCE 642
Query: 1442 AMLGSWFAQ--CTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQE 1499
L W ++ TVL+IAHRL++V ++LV+ +G++ + AQL + L+ RL Q+
Sbjct: 643 QALQDWNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQKL---AQLQEGQDLYSRLVQQ 699
Score = 82.4 bits (202), Expect = 3e-15
Identities = 61/226 (26%), Positives = 104/226 (46%), Gaps = 20/226 (8%)
Query: 629 ITIHSATFAW-SQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFV 687
+ +FA+ ++ P L + T+ G + A+VGP G+GKS++ + L G V
Sbjct: 468 VKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQV 527
Query: 688 SIE-------------GAVAYVPQEAWVQNTSVVENVCFG-QELDPPWLERVLEACALQP 733
++ V V QE + + SV N+ +G Q + + +A
Sbjct: 528 LLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADD 587
Query: 734 DVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFN 793
+ GI+T +GE+G L+ GQKQRL++ARA+ R V +LD+ +ALD
Sbjct: 588 FIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQC-----E 642
Query: 794 QVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQE 839
Q + T +++ H L + +A I+VL G + ++ QE
Sbjct: 643 QALQDWNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQKLAQLQE 688
>gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 143 bits (360), Expect = 1e-33
Identities = 141/533 (26%), Positives = 240/533 (45%), Gaps = 48/533 (9%)
Query: 996 CLQAIGLFASMAAVLLGG------ARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFS 1049
CL AIG +S AA + GG AR + L L +V SFF+ G L++R +
Sbjct: 233 CLLAIG--SSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLT 290
Query: 1050 KETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSS 1109
+T V + + L ++V+ VV L+ L F+ GF + +VS+
Sbjct: 291 SDTTMVSDLVSQNINVFLR---NTVKVTGVVVFMFSLSWQLSLVTFM---GFPIIMMVSN 344
Query: 1110 C------QLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFP 1163
+L + + + + ET VR+F + ++ + +++
Sbjct: 345 IYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRK 404
Query: 1164 RLVADRWLAANVELLGNGLVFAAATCAVL--------SKAHLSAGLVGFSVSAALQVTQT 1215
A + + G+GL ++L S S L+ F + + +
Sbjct: 405 EAAAYMYY-----VWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFV-LGDC 458
Query: 1216 LQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCA---AQPPWPQGGQIEFRD--F 1270
++ V ++ L + + E++ ++ R PT + P G+++F + F
Sbjct: 459 MESVGSVYSGLMQGVGAAEKVFEFID-------RQPTMVHDGSLAPDHLEGRVDFENVTF 511
Query: 1271 GLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPI 1330
R RP + +Q VSF + G+ +VG +G+GKSS + L G + +DG PI
Sbjct: 512 TYRTRPHTQV-LQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPI 570
Query: 1331 AHVGLHTLRSRISIIPQDPILFPGSLRMNLDL-LQEHSDEAIWAALETVQLKALVASLPG 1389
+ L IS++ Q+P+LF S+ N+ L E + A + + L
Sbjct: 571 SAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQD 630
Query: 1390 QLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFA 1449
+ ++G LS GQKQ + +ARAL+R +LILDEAT+A+D +E +Q +
Sbjct: 631 GYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQ 690
Query: 1450 QCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQESGL 1502
+ TVL+IAHRL +V ++V+DKG+V + G+ QLLAQ GL+ +L Q L
Sbjct: 691 KHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQML 743
Score = 102 bits (255), Expect = 2e-21
Identities = 116/517 (22%), Positives = 225/517 (43%), Gaps = 43/517 (8%)
Query: 380 RLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESV-----LYLNGLWLPL 434
RL + ++R +++ + + GD+++ ++ D +++ V ++L
Sbjct: 256 RLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVT 315
Query: 435 VWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFF--ISKKRNHHQEEQMRQKDSRARLTS 492
+V F WQL S +T + + ++ N + K+ + + + + + A T
Sbjct: 316 GVVVFMFSLSWQL---SLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETI 372
Query: 493 SILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFA 552
S ++ ++ E R L + +L + ++ V + V+++ +
Sbjct: 373 SAMKTVRSFANEEEEAEVYLRKLQ-QVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYG 431
Query: 553 VHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDP 612
H LV M + + +L + L+Q + +++ F+ + P
Sbjct: 432 GH-LVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFI---DRQP 487
Query: 613 GVVDSSSSGSAAGKDCITIHSATFAW-SQESPPCLHRINLTVPQGCLLAVVGPVGAGKSS 671
+V S + + + TF + ++ L ++ ++ G + A+VGP G+GKSS
Sbjct: 488 TMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSS 547
Query: 672 LLSALLGELSKVEGFVSIEG-------------AVAYVPQEAWVQNTSVVENVCFGQELD 718
++ L G V ++G ++ V QE + S+ +N+ +G
Sbjct: 548 CVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTV 607
Query: 719 PPWLERVLEACALQPDVDSF----PEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVY 774
P E V+EA A + + F +G T GE+G LSGGQKQR+++ARA+ R V
Sbjct: 608 P--FEMVVEA-AQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVL 664
Query: 775 LLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEM 834
+LD+ +ALDA +++ Q I G LQ T +++ H L + A I+VL G + +
Sbjct: 665 ILDEATSALDAE-SEYLIQQAI--HGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQ 721
Query: 835 GSYQELLQRKGALVCLLDQ---ARQP-GDRGEGETEP 867
G++Q+LL + G L+ + QP D G EP
Sbjct: 722 GTHQQLLAQGGLYAKLVQRQMLGLQPAADFTAGHNEP 758
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.136 0.417
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 56,811,489
Number of Sequences: 37866
Number of extensions: 2550728
Number of successful extensions: 7428
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 73
Number of HSP's successfully gapped in prelim test: 24
Number of HSP's that attempted gapping in prelim test: 6780
Number of HSP's gapped (non-prelim): 322
length of query: 1503
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1388
effective length of database: 13,892,928
effective search space: 19283384064
effective search space used: 19283384064
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.