Guide to the Human Genome
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Search of human proteins with 189571683

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|189571683 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
         (476 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|189571685 WD repeat, sterile alpha motif and U-box domain con...   981   0.0  
gi|189571683 WD repeat, sterile alpha motif and U-box domain con...   981   0.0  
gi|189571681 WD repeat, sterile alpha motif and U-box domain con...   981   0.0  
gi|113865883 WD repeat domain 38 [Homo sapiens]                       119   5e-27
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]            104   2e-22
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]            104   2e-22
gi|32189425 WD repeat domain 69 [Homo sapiens]                        103   4e-22
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]             98   2e-20
gi|26665869 WD repeat domain 51B [Homo sapiens]                        97   4e-20
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]    93   6e-19
gi|13376840 WD repeat domain 61 [Homo sapiens]                         93   6e-19
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H...    90   4e-18
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho...    90   4e-18
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa...    89   1e-17
gi|4557741 platelet-activating factor acetylhydrolase, isoform I...    88   1e-17
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H...    88   1e-17
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho...    88   1e-17
gi|16554629 WD repeat domain 5 [Homo sapiens]                          88   2e-17
gi|16554627 WD repeat domain 5 [Homo sapiens]                          88   2e-17
gi|21536371 telomerase-associated protein 1 [Homo sapiens]             87   4e-17
gi|23199987 WD repeat domain 5B [Homo sapiens]                         87   4e-17
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H...    83   5e-16
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H...    83   5e-16
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H...    83   5e-16
gi|21071067 TBP-associated factor 5 [Homo sapiens]                     82   1e-15
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s...    80   5e-15
gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo ...    79   1e-14
gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo ...    79   1e-14
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                     78   2e-14
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]          76   8e-14

>gi|189571685 WD repeat, sterile alpha motif and U-box domain
           containing 1 [Homo sapiens]
          Length = 476

 Score =  981 bits (2537), Expect = 0.0
 Identities = 476/476 (100%), Positives = 476/476 (100%)

Query: 1   MVKLIHTLADHGDDVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCC 60
           MVKLIHTLADHGDDVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCC
Sbjct: 1   MVKLIHTLADHGDDVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCC 60

Query: 61  CFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGT 120
           CFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGT
Sbjct: 61  CFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGT 120

Query: 121 VVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHD 180
           VVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHD
Sbjct: 121 VVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHD 180

Query: 181 LGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCA 240
           LGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCA
Sbjct: 181 LGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCA 240

Query: 241 PVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGS 300
           PVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGS
Sbjct: 241 PVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGS 300

Query: 301 MDKTVNIWQFDLETLCQARRTEHQLKQFTEDWSEEDVSTWLCAQDLKDLVGIFKMNNIDG 360
           MDKTVNIWQFDLETLCQARRTEHQLKQFTEDWSEEDVSTWLCAQDLKDLVGIFKMNNIDG
Sbjct: 301 MDKTVNIWQFDLETLCQARRTEHQLKQFTEDWSEEDVSTWLCAQDLKDLVGIFKMNNIDG 360

Query: 361 KELLNLTKESLADDLKIESLGLRSKVLRKIEELRTKVKSLSSGIPDEFICPITRELMKDP 420
           KELLNLTKESLADDLKIESLGLRSKVLRKIEELRTKVKSLSSGIPDEFICPITRELMKDP
Sbjct: 361 KELLNLTKESLADDLKIESLGLRSKVLRKIEELRTKVKSLSSGIPDEFICPITRELMKDP 420

Query: 421 VIASDGYSYEKEAMENWISKKKRTSPMTNLVLPSAVLTPNRTLKMAINRWLETHQK 476
           VIASDGYSYEKEAMENWISKKKRTSPMTNLVLPSAVLTPNRTLKMAINRWLETHQK
Sbjct: 421 VIASDGYSYEKEAMENWISKKKRTSPMTNLVLPSAVLTPNRTLKMAINRWLETHQK 476


>gi|189571683 WD repeat, sterile alpha motif and U-box domain
           containing 1 [Homo sapiens]
          Length = 476

 Score =  981 bits (2537), Expect = 0.0
 Identities = 476/476 (100%), Positives = 476/476 (100%)

Query: 1   MVKLIHTLADHGDDVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCC 60
           MVKLIHTLADHGDDVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCC
Sbjct: 1   MVKLIHTLADHGDDVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCC 60

Query: 61  CFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGT 120
           CFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGT
Sbjct: 61  CFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGT 120

Query: 121 VVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHD 180
           VVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHD
Sbjct: 121 VVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHD 180

Query: 181 LGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCA 240
           LGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCA
Sbjct: 181 LGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCA 240

Query: 241 PVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGS 300
           PVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGS
Sbjct: 241 PVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGS 300

Query: 301 MDKTVNIWQFDLETLCQARRTEHQLKQFTEDWSEEDVSTWLCAQDLKDLVGIFKMNNIDG 360
           MDKTVNIWQFDLETLCQARRTEHQLKQFTEDWSEEDVSTWLCAQDLKDLVGIFKMNNIDG
Sbjct: 301 MDKTVNIWQFDLETLCQARRTEHQLKQFTEDWSEEDVSTWLCAQDLKDLVGIFKMNNIDG 360

Query: 361 KELLNLTKESLADDLKIESLGLRSKVLRKIEELRTKVKSLSSGIPDEFICPITRELMKDP 420
           KELLNLTKESLADDLKIESLGLRSKVLRKIEELRTKVKSLSSGIPDEFICPITRELMKDP
Sbjct: 361 KELLNLTKESLADDLKIESLGLRSKVLRKIEELRTKVKSLSSGIPDEFICPITRELMKDP 420

Query: 421 VIASDGYSYEKEAMENWISKKKRTSPMTNLVLPSAVLTPNRTLKMAINRWLETHQK 476
           VIASDGYSYEKEAMENWISKKKRTSPMTNLVLPSAVLTPNRTLKMAINRWLETHQK
Sbjct: 421 VIASDGYSYEKEAMENWISKKKRTSPMTNLVLPSAVLTPNRTLKMAINRWLETHQK 476


>gi|189571681 WD repeat, sterile alpha motif and U-box domain
           containing 1 [Homo sapiens]
          Length = 476

 Score =  981 bits (2537), Expect = 0.0
 Identities = 476/476 (100%), Positives = 476/476 (100%)

Query: 1   MVKLIHTLADHGDDVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCC 60
           MVKLIHTLADHGDDVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCC
Sbjct: 1   MVKLIHTLADHGDDVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCC 60

Query: 61  CFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGT 120
           CFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGT
Sbjct: 61  CFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGT 120

Query: 121 VVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHD 180
           VVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHD
Sbjct: 121 VVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHD 180

Query: 181 LGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCA 240
           LGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCA
Sbjct: 181 LGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCA 240

Query: 241 PVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGS 300
           PVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGS
Sbjct: 241 PVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGS 300

Query: 301 MDKTVNIWQFDLETLCQARRTEHQLKQFTEDWSEEDVSTWLCAQDLKDLVGIFKMNNIDG 360
           MDKTVNIWQFDLETLCQARRTEHQLKQFTEDWSEEDVSTWLCAQDLKDLVGIFKMNNIDG
Sbjct: 301 MDKTVNIWQFDLETLCQARRTEHQLKQFTEDWSEEDVSTWLCAQDLKDLVGIFKMNNIDG 360

Query: 361 KELLNLTKESLADDLKIESLGLRSKVLRKIEELRTKVKSLSSGIPDEFICPITRELMKDP 420
           KELLNLTKESLADDLKIESLGLRSKVLRKIEELRTKVKSLSSGIPDEFICPITRELMKDP
Sbjct: 361 KELLNLTKESLADDLKIESLGLRSKVLRKIEELRTKVKSLSSGIPDEFICPITRELMKDP 420

Query: 421 VIASDGYSYEKEAMENWISKKKRTSPMTNLVLPSAVLTPNRTLKMAINRWLETHQK 476
           VIASDGYSYEKEAMENWISKKKRTSPMTNLVLPSAVLTPNRTLKMAINRWLETHQK
Sbjct: 421 VIASDGYSYEKEAMENWISKKKRTSPMTNLVLPSAVLTPNRTLKMAINRWLETHQK 476


>gi|113865883 WD repeat domain 38 [Homo sapiens]
          Length = 314

 Score =  119 bits (299), Expect = 5e-27
 Identities = 100/309 (32%), Positives = 138/309 (44%), Gaps = 27/309 (8%)

Query: 2   VKLIHTLADHGDDVNCCAFS--FSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHC 59
           V+ +     HG +VN  AFS    +L T S D  +  +  R    L    L  HT  V  
Sbjct: 11  VRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWR--LGGHTGPVKF 68

Query: 60  CCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADG 119
           C FSP GH+ AS S D T  LW+    + L V++    S V    FSPDS  LASG  D 
Sbjct: 69  CRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRS-VETVSFSPDSRQLASGGWDK 127

Query: 120 TVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM---RCLHSE 176
            V+LW+ QS ++ R       S+ +  FSP  +   TGS    + +WD +M      H  
Sbjct: 128 RVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQA 187

Query: 177 -KAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTL 235
            + H   I+C  +S+  +           LAS   D  + IW  + + +L         L
Sbjct: 188 LEGHSANISCLCYSASGL-----------LASGSWDKTIHIWKPTTSSLL-------IQL 229

Query: 236 SGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLL 295
            GH   V + AFS D   L S    + V V+D NT   L TL        TCAF P+  +
Sbjct: 230 KGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKI 289

Query: 296 LATGSMDKT 304
           L +G+ D+T
Sbjct: 290 LVSGAADQT 298



 Score =  101 bits (251), Expect = 2e-21
 Identities = 80/268 (29%), Positives = 118/268 (44%), Gaps = 21/268 (7%)

Query: 53  HTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCL 112
           H   V+   FSP G +L + S DG    W T +GQ+L  +   +G PV+ C+FSPD    
Sbjct: 20  HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTG-PVKFCRFSPDGHLF 78

Query: 113 ASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM-R 171
           AS + D TV LW+    K  R       S+   +FSP+     +G     + +WD +  +
Sbjct: 79  ASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQ 138

Query: 172 CLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKY 231
            L     H   I   DFS               LA+   D  V IW +            
Sbjct: 139 MLRLLVGHRDSIQSSDFSPTVNC----------LATGSWDSTVHIWDLRMVT----PAVS 184

Query: 232 KSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAP 291
              L GH A +    +S  G +L SGS DK++ ++   T ++L  L  H  +V + AF+P
Sbjct: 185 HQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSP 243

Query: 292 NTLLLATGSMDKTVNIWQFD----LETL 315
           + L LA+    + V +W  +    LETL
Sbjct: 244 DELWLASAGYSRMVKVWDCNTGKCLETL 271


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score =  104 bits (259), Expect = 2e-22
 Identities = 87/308 (28%), Positives = 133/308 (43%), Gaps = 27/308 (8%)

Query: 11  HGDDVNCCAFSFSL--LATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHI 68
           H D V C  FS +   LA+ S+D  + ++ ++  +         H  AV C  FSPSGH+
Sbjct: 18  HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYR--FTGHKDAVTCVNFSPSGHL 75

Query: 69  LASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQS 128
           LAS S D T  +W   N +  + + +   + VR   F  D     + + D TV +W    
Sbjct: 76  LASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134

Query: 129 YKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMR-CLHSEKAHDLGITCCD 187
            K     S     +    FSP+G   V+ S    + +WD   R C+HS   H   +T  D
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194

Query: 188 FSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILG-FELKYKSTLSGHCAPVLACA 246
           F                +A+ G D  VK+W V    +L  ++L        H A V   +
Sbjct: 195 FHPSGTC----------IAAAGMDNTVKVWDVRTHRLLQHYQL--------HSAAVNGLS 236

Query: 247 FSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVN 306
           F   G  L++ S D ++ + D     +L+TL  H    TT AF+      A+G  D+ V 
Sbjct: 237 FHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVM 296

Query: 307 IWQ--FDL 312
           +W+  FD+
Sbjct: 297 VWKSNFDI 304



 Score = 82.4 bits (202), Expect = 8e-16
 Identities = 62/220 (28%), Positives = 102/220 (46%), Gaps = 20/220 (9%)

Query: 100 VRVCQFSPDSTCLASGAADGTVVLWNAQSY-KLYRCGSVKDGSLAACAFSPNGSFFVTGS 158
           V    FS ++  LASG+ D  +++W+ +   + YR    KD ++    FSP+G    +GS
Sbjct: 22  VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKD-AVTCVNFSPSGHLLASGS 80

Query: 159 SCGDLTVWDDKMRCLHSE-KAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIW 217
               + +W   ++   +  +AH   +    F S    DG+         +   D  VK+W
Sbjct: 81  RDKTVRIWVPNVKGESTVFRAHTATVRSVHFCS----DGQS------FVTASDDKTVKVW 130

Query: 218 IVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTL 277
               TH      K+  +LS H   V    FS DG+++VS S DK+V ++D ++   +H+ 
Sbjct: 131 A---TH----RQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSY 183

Query: 278 TQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFDLETLCQ 317
            +H  +VT   F P+   +A   MD TV +W      L Q
Sbjct: 184 CEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQ 223



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 28/72 (38%), Positives = 40/72 (55%)

Query: 237 GHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLL 296
           GH   V    FS + + L SGS+D  ++V+    ++  +  T H   VT   F+P+  LL
Sbjct: 17  GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76

Query: 297 ATGSMDKTVNIW 308
           A+GS DKTV IW
Sbjct: 77  ASGSRDKTVRIW 88


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score =  104 bits (259), Expect = 2e-22
 Identities = 87/308 (28%), Positives = 133/308 (43%), Gaps = 27/308 (8%)

Query: 11  HGDDVNCCAFSFSL--LATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHI 68
           H D V C  FS +   LA+ S+D  + ++ ++  +         H  AV C  FSPSGH+
Sbjct: 18  HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYR--FTGHKDAVTCVNFSPSGHL 75

Query: 69  LASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQS 128
           LAS S D T  +W   N +  + + +   + VR   F  D     + + D TV +W    
Sbjct: 76  LASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134

Query: 129 YKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMR-CLHSEKAHDLGITCCD 187
            K     S     +    FSP+G   V+ S    + +WD   R C+HS   H   +T  D
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194

Query: 188 FSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILG-FELKYKSTLSGHCAPVLACA 246
           F                +A+ G D  VK+W V    +L  ++L        H A V   +
Sbjct: 195 FHPSGTC----------IAAAGMDNTVKVWDVRTHRLLQHYQL--------HSAAVNGLS 236

Query: 247 FSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVN 306
           F   G  L++ S D ++ + D     +L+TL  H    TT AF+      A+G  D+ V 
Sbjct: 237 FHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVM 296

Query: 307 IWQ--FDL 312
           +W+  FD+
Sbjct: 297 VWKSNFDI 304



 Score = 82.4 bits (202), Expect = 8e-16
 Identities = 62/220 (28%), Positives = 102/220 (46%), Gaps = 20/220 (9%)

Query: 100 VRVCQFSPDSTCLASGAADGTVVLWNAQSY-KLYRCGSVKDGSLAACAFSPNGSFFVTGS 158
           V    FS ++  LASG+ D  +++W+ +   + YR    KD ++    FSP+G    +GS
Sbjct: 22  VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKD-AVTCVNFSPSGHLLASGS 80

Query: 159 SCGDLTVWDDKMRCLHSE-KAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIW 217
               + +W   ++   +  +AH   +    F S    DG+         +   D  VK+W
Sbjct: 81  RDKTVRIWVPNVKGESTVFRAHTATVRSVHFCS----DGQS------FVTASDDKTVKVW 130

Query: 218 IVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTL 277
               TH      K+  +LS H   V    FS DG+++VS S DK+V ++D ++   +H+ 
Sbjct: 131 A---TH----RQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSY 183

Query: 278 TQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFDLETLCQ 317
            +H  +VT   F P+   +A   MD TV +W      L Q
Sbjct: 184 CEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQ 223



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 28/72 (38%), Positives = 40/72 (55%)

Query: 237 GHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLL 296
           GH   V    FS + + L SGS+D  ++V+    ++  +  T H   VT   F+P+  LL
Sbjct: 17  GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76

Query: 297 ATGSMDKTVNIW 308
           A+GS DKTV IW
Sbjct: 77  ASGSRDKTVRIW 88


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score =  103 bits (256), Expect = 4e-22
 Identities = 79/311 (25%), Positives = 144/311 (46%), Gaps = 28/311 (9%)

Query: 5   IHTLADHGDDVNCCAFSFSL---LATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCC 61
           ++TL  H + V   AF+      +AT S DKT +L+S+   T   +   + HT  + C  
Sbjct: 127 LNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVE--TGKCYHTFRGHTAEIVCLS 184

Query: 62  FSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTV 121
           F+P   ++A+ S D T  LW+ +NG+ +  +   S   + +  F+     + +G+ D TV
Sbjct: 185 FNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISL-SFNTSGDRIITGSFDHTV 243

Query: 122 VLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD-DKMRCLHSEKAHD 180
           V+W+A + +           +++ +F+ + S  +TGS      +WD    +C+ +   HD
Sbjct: 244 VVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHD 303

Query: 181 LGI--TCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGH 238
             I  +C D++ + +            A+   D   +I+  +    +       + L GH
Sbjct: 304 DEILDSCFDYTGKLI------------ATASADGTARIFSAATRKCI-------AKLEGH 344

Query: 239 CAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLAT 298
              +   +F+  G  L++GS DK+  ++D  T   L  L  HT  + +CAF     ++ T
Sbjct: 345 EGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVIT 404

Query: 299 GSMDKTVNIWQ 309
           GS D T  IW+
Sbjct: 405 GSKDNTCRIWR 415



 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 57/212 (26%), Positives = 96/212 (45%), Gaps = 19/212 (8%)

Query: 99  PVRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFS-PNGSFFVTG 157
           P+     +   +C  +G+ D T  LW+  S +           + A AF+ P G    TG
Sbjct: 94  PLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATG 153

Query: 158 SSCGDLTVWD-DKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKI 216
           S      +W  +  +C H+ + H   I C  F+ Q             +A+   D   K+
Sbjct: 154 SFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTL----------VATGSMDTTAKL 203

Query: 217 WIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHT 276
           W      I   E  Y  TL GH A +++ +F+  G  +++GS D +V+V+D +T   ++ 
Sbjct: 204 W-----DIQNGEEVY--TLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNI 256

Query: 277 LTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
           L  H   +++ +F  +  L+ TGSMDKT  +W
Sbjct: 257 LIGHCAEISSASFNWDCSLILTGSMDKTCKLW 288



 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 62/260 (23%), Positives = 110/260 (42%), Gaps = 18/260 (6%)

Query: 50  LKFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDS 109
           LK H   +     + SG    + S D T  LW+T +G+ L  +E        +   +P  
Sbjct: 88  LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYG 147

Query: 110 TCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD-D 168
             +A+G+ D T  LW+ ++ K Y         +   +F+P  +   TGS      +WD  
Sbjct: 148 DKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQ 207

Query: 169 KMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFE 228
               +++ + H   I    F+    + G+      R+ +   D  V +W           
Sbjct: 208 NGEEVYTLRGHSAEIISLSFN----TSGD------RIITGSFDHTVVVWDADTG------ 251

Query: 229 LKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCA 288
            +  + L GHCA + + +F+ D  ++++GS+DK+  ++D      + TLT H   +    
Sbjct: 252 -RKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSC 310

Query: 289 FAPNTLLLATGSMDKTVNIW 308
           F     L+AT S D T  I+
Sbjct: 311 FDYTGKLIATASADGTARIF 330



 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 42/171 (24%), Positives = 76/171 (44%), Gaps = 17/171 (9%)

Query: 142 LAACAFSPNGSFFVTGSSCGDLTVWDDKM-RCLHSEKAHDLGITCCDFSSQPVSDGEQGL 200
           L   A + +GS F+TGS      +WD      L++ + H   +    F++ P  D     
Sbjct: 95  LTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNN-PYGD----- 148

Query: 201 QFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVD 260
              ++A+   D   K+W V          K   T  GH A ++  +F+    ++ +GS+D
Sbjct: 149 ---KIATGSFDKTCKLWSVETG-------KCYHTFRGHTAEIVCLSFNPQSTLVATGSMD 198

Query: 261 KSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFD 311
            +  ++D      ++TL  H+  + + +F  +   + TGS D TV +W  D
Sbjct: 199 TTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDAD 249


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 77/264 (29%), Positives = 114/264 (43%), Gaps = 23/264 (8%)

Query: 53  HTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCL 112
           H  AV C  FSPSGH+LAS S D T  +W   N +  + + +   + VR   F  D    
Sbjct: 22  HKDAVTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSF 80

Query: 113 ASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMR- 171
            + + D TV +W     K     S     +    FSP+G   V+ S    + +WD   R 
Sbjct: 81  VTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE 140

Query: 172 CLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILG-FELK 230
           C+HS   H   +T  DF                +A+ G D  VK+W V    +L  ++L 
Sbjct: 141 CVHSYCEHGGFVTYVDFHPSGTC----------IAAAGMDNTVKVWDVRTHRLLQHYQL- 189

Query: 231 YKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFA 290
                  H A V   +F   G  L++ S D ++ + D     +L+TL  H    TT AF+
Sbjct: 190 -------HSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFS 242

Query: 291 PNTLLLATGSMDKTVNIWQ--FDL 312
                 A+G  D+ V +W+  FD+
Sbjct: 243 RTGEYFASGGSDEQVMVWKSNFDI 266



 Score = 82.8 bits (203), Expect = 6e-16
 Identities = 81/294 (27%), Positives = 118/294 (40%), Gaps = 29/294 (9%)

Query: 11  HGDDVNCCAFSFS--LLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHI 68
           H D V C  FS S  LLA+ S DKT+R++      E   +  + HT  V    F   G  
Sbjct: 22  HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGE--STVFRAHTATVRSVHFCSDGQS 79

Query: 69  LASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQS 128
             + S D T  +W T   + L  + Q     VR  +FSPD   + S + D TV LW+  S
Sbjct: 80  FVTASDDKTVKVWATHRQKFLFSLSQHINW-VRCAKFSPDGRLIVSASDDKTVKLWDKSS 138

Query: 129 YKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM-RCLHSEKAHDLGITCCD 187
            +         G +    F P+G+          + VWD +  R L   + H   +    
Sbjct: 139 RECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLS 198

Query: 188 FSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAF 247
           F   P  +         L +   D  +KI       ++   L Y  TL GH  P    AF
Sbjct: 199 F--HPSGN--------YLITASSDSTLKI-----LDLMEGRLLY--TLHGHQGPATTVAF 241

Query: 248 SHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSM 301
           S  G+   SG  D+ V+V+ +N + + H        VT     P TL  + G++
Sbjct: 242 SRTGEYFASGGSDEQVMVWKSNFDIVDH------GEVTKVPRPPATLASSMGNL 289



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 55/202 (27%), Positives = 92/202 (45%), Gaps = 20/202 (9%)

Query: 118 DGTVVLWNAQSY-KLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCLHSE 176
           D  +++W+ +   + YR    KD ++    FSP+G    +GS    + +W   ++   + 
Sbjct: 2   DSCLMVWHMKPQSRAYRFTGHKD-AVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV 60

Query: 177 -KAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTL 235
            +AH   +    F S    DG+         +   D  VK+W    TH      K+  +L
Sbjct: 61  FRAHTATVRSVHFCS----DGQS------FVTASDDKTVKVWA---TH----RQKFLFSL 103

Query: 236 SGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLL 295
           S H   V    FS DG+++VS S DK+V ++D ++   +H+  +H  +VT   F P+   
Sbjct: 104 SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTC 163

Query: 296 LATGSMDKTVNIWQFDLETLCQ 317
           +A   MD TV +W      L Q
Sbjct: 164 IAAAGMDNTVKVWDVRTHRLLQ 185



 Score = 38.9 bits (89), Expect = 0.010
 Identities = 19/50 (38%), Positives = 29/50 (58%)

Query: 259 VDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
           +D  ++V+    ++  +  T H   VT   F+P+  LLA+GS DKTV IW
Sbjct: 1   MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW 50


>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score = 96.7 bits (239), Expect = 4e-20
 Identities = 64/201 (31%), Positives = 102/201 (50%), Gaps = 14/201 (6%)

Query: 25  LATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTE 84
           LAT S DK+I+++S+  + +     L  HT+ V C  FSP G ++ SCS D T  +W+T 
Sbjct: 117 LATASEDKSIKVWSM--YRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTT 174

Query: 85  NGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAA 144
           N Q +       G       F+P  TC+AS  +D TV +W+ +  KL +   V  G +  
Sbjct: 175 NKQCVNNFSDSVGF-ANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNC 233

Query: 145 CAFSPNGSFFVTGSSCGDLTVWD-DKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFF 203
            +F P+G++ +T SS G L + D  + R +++ + H   +    FS        +G + F
Sbjct: 234 ISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFS--------KGGELF 285

Query: 204 RLASCGQDCQVKIWIVSFTHI 224
             AS G D QV +W  +F  +
Sbjct: 286 --ASGGADTQVLLWRTNFDEL 304



 Score = 88.2 bits (217), Expect = 1e-17
 Identities = 84/316 (26%), Positives = 132/316 (41%), Gaps = 37/316 (11%)

Query: 25  LATCSLDKTIRLYSLRDFTELPHSPLKF---HTYAVHCCCFSPSGHILASCSTDGTTVLW 81
           LAT S D  + L++ +     PH+       H   V    FSP G++LAS S D T  LW
Sbjct: 33  LATASWDTFLMLWNFK-----PHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLW 87

Query: 82  NTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQS----YKLYRCGSV 137
             +     +  +  + +PVR   FS D   LA+ + D ++ +W+       Y LYR    
Sbjct: 88  IPDKRGKFSEFKAHT-APVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYR---- 142

Query: 138 KDGSLAACA-FSPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHDLGIT-CCDFSSQPVSD 195
                  CA FSP+G   V+ S    + +WD   +   +  +  +G     DF+      
Sbjct: 143 -HTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTC- 200

Query: 196 GEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLV 255
                    +AS G D  VK+W V    +L            H   V   +F   G  L+
Sbjct: 201 ---------IASAGSDQTVKVWDVRVNKLL-------QHYQVHSGGVNCISFHPSGNYLI 244

Query: 256 SGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFDLETL 315
           + S D ++ + D     +++TL  HT  V T +F+    L A+G  D  V +W+ + + L
Sbjct: 245 TASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDEL 304

Query: 316 CQARRTEHQLKQFTED 331
                T+  LK+   D
Sbjct: 305 HCKGLTKRNLKRLHFD 320



 Score = 79.3 bits (194), Expect = 7e-15
 Identities = 59/214 (27%), Positives = 103/214 (48%), Gaps = 20/214 (9%)

Query: 106 SPDSTCLASGAADGTVVLWNAQSY-KLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLT 164
           SP+   LA+ + D  ++LWN + + + YR    KD  + +  FSP+G+   + S    + 
Sbjct: 27  SPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKD-VVTSVQFSPHGNLLASASRDRTVR 85

Query: 165 VWDDKMRCLHSE-KAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTH 223
           +W    R   SE KAH   +   DFS+    DG    QF  LA+  +D  +K+W +    
Sbjct: 86  LWIPDKRGKFSEFKAHTAPVRSVDFSA----DG----QF--LATASEDKSIKVWSM---- 131

Query: 224 ILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRY 283
              +  ++  +L  H   V    FS DG+++VS S DK++ ++DT  +  ++  +    +
Sbjct: 132 ---YRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGF 188

Query: 284 VTTCAFAPNTLLLATGSMDKTVNIWQFDLETLCQ 317
                F P+   +A+   D+TV +W   +  L Q
Sbjct: 189 ANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQ 222



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 50/169 (29%), Positives = 75/169 (44%), Gaps = 18/169 (10%)

Query: 141 SLAACAFSPNGSFFVTGSSCGDLTVWDDKMRC-LHSEKAHDLGITCCDFSSQPVSDGEQG 199
           ++ +   SPNG    T S    L +W+ K     +    H   +T   FS          
Sbjct: 20  AITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNL----- 74

Query: 200 LQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSV 259
                LAS  +D  V++WI         +    S    H APV +  FS DGQ L + S 
Sbjct: 75  -----LASASRDRTVRLWIPD-------KRGKFSEFKAHTAPVRSVDFSADGQFLATASE 122

Query: 260 DKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
           DKS+ V+    +  L++L +HT +V    F+P+  L+ + S DKT+ IW
Sbjct: 123 DKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIW 171



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 21/72 (29%), Positives = 38/72 (52%)

Query: 237 GHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLL 296
           GH A + +   S +G+ L + S D  +++++       +    H   VT+  F+P+  LL
Sbjct: 16  GHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLL 75

Query: 297 ATGSMDKTVNIW 308
           A+ S D+TV +W
Sbjct: 76  ASASRDRTVRLW 87


>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
          Length = 357

 Score = 92.8 bits (229), Expect = 6e-19
 Identities = 81/306 (26%), Positives = 140/306 (45%), Gaps = 22/306 (7%)

Query: 5   IHTLADHGDDVNCCAF--SFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCF 62
           I  L+ H  +V CC F  + S LA+   D+ I L+++    +  ++ LK H+ AV    +
Sbjct: 59  IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCD-NYATLKGHSGAVMELHY 117

Query: 63  SPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVC---QFSPDSTCLASGAADG 119
           +  G +L S STD T  +W++E G+ +  ++  + S V  C   +  P   C  +G+ DG
Sbjct: 118 NTDGSMLFSASTDKTVAVWDSETGERVKRLKGHT-SFVNSCYPARRGPQLVC--TGSDDG 174

Query: 120 TVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCL-HSEKA 178
           TV LW+ +     +        + A  F+      ++G    D+ VWD +   L ++ + 
Sbjct: 175 TVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRG 233

Query: 179 HDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVS-FTHILGFELKYKSTLSG 237
           H   +T    SS+             L S   D  V++W V  F         ++  +  
Sbjct: 234 HADSVTGLSLSSEGSY----------LLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHN 283

Query: 238 HCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLA 297
               +L C++S DG  + +GS D+ V V+DT +  IL+ L  H   +   AF P+  ++ 
Sbjct: 284 FEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIII 343

Query: 298 TGSMDK 303
           + S DK
Sbjct: 344 SASSDK 349



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 52/212 (24%), Positives = 87/212 (41%), Gaps = 21/212 (9%)

Query: 100 VRVCQFSPDSTCLASGAADGTVVLWNAQS-YKLYRCGSVKDGSLAACAFSPNGSFFVTGS 158
           V  C+F P+ + LAS   D  ++LWN       Y       G++    ++ +GS   + S
Sbjct: 69  VYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSAS 128

Query: 159 SCGDLTVWDDKM-RCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIW 217
           +   + VWD +    +   K H   +  C     P   G Q      + +   D  VK+W
Sbjct: 129 TDKTVAVWDSETGERVKRLKGHTSFVNSC----YPARRGPQ-----LVCTGSDDGTVKLW 179

Query: 218 -IVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHT 276
            I     I  F+  Y+         VLA  F+     ++SG +D  + V+D     + +T
Sbjct: 180 DIRKKAAIQTFQNTYQ---------VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYT 230

Query: 277 LTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
           +  H   VT  + +     L + +MD TV +W
Sbjct: 231 MRGHADSVTGLSLSSEGSYLLSNAMDNTVRVW 262



 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 49/162 (30%), Positives = 75/162 (46%), Gaps = 18/162 (11%)

Query: 179 HDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGH 238
           H+  + CC F     +          LAS G D  + +W     ++ G    Y +TL GH
Sbjct: 65  HEGEVYCCKFHPNGST----------LASAGFDRLILLW-----NVYGDCDNY-ATLKGH 108

Query: 239 CAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPN-TLLLA 297
              V+   ++ DG ML S S DK+V V+D+ T   +  L  HT +V +C  A     L+ 
Sbjct: 109 SGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVC 168

Query: 298 TGSMDKTVNIWQFDLETLCQARRTEHQLKQFT-EDWSEEDVS 338
           TGS D TV +W    +   Q  +  +Q+   T  D S++ +S
Sbjct: 169 TGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIIS 210


>gi|13376840 WD repeat domain 61 [Homo sapiens]
          Length = 305

 Score = 92.8 bits (229), Expect = 6e-19
 Identities = 82/287 (28%), Positives = 128/287 (44%), Gaps = 23/287 (8%)

Query: 25  LATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTE 84
           + T SLD  ++++  RD        L+ H   V     S +  I AS S D    LW+ E
Sbjct: 35  VVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLE 94

Query: 85  NGQMLAVMEQPSGSPVRV--CQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSL 142
           NG+ +  ++     PV      FSPDS  LA+G   G V ++  +S K       +   +
Sbjct: 95  NGKQIKSID---AGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFI 151

Query: 143 AACAFSPNGSFFVTGSSCGDLTVWDDKM-RCLHSEKAHDLGITCCDFSSQPVSDGEQGLQ 201
            + A+SP+G +  +G+  G + ++D    + LH+ + H + I    FS  P S       
Sbjct: 152 LSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFS--PDSQ------ 203

Query: 202 FFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDK 261
              L +   D  +KI+ V   ++ G       TLSGH + VL  AF  D    VS S DK
Sbjct: 204 --LLVTASDDGYIKIYDVQHANLAG-------TLSGHASWVLNVAFCPDDTHFVSSSSDK 254

Query: 262 SVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
           SV V+D  T   +HT   H   V    +  N   + +   D+ ++I+
Sbjct: 255 SVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301



 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 60/217 (27%), Positives = 98/217 (45%), Gaps = 27/217 (12%)

Query: 113 ASGAADGTVVLWNAQSYKLYRCGSVKDGSLAA--CAFSPNGSFFVTGSSCGDLTVWDDKM 170
           AS + D  + LW+ ++ K  +  S+  G + A   AFSP+  +  TG+  G + ++  + 
Sbjct: 80  ASSSLDAHIRLWDLENGKQIK--SIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVES 137

Query: 171 RCLHSEKAHDL---GITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGF 227
                +K + L   G      +  P  DG+       LAS   D  + I+ ++   +L  
Sbjct: 138 ----GKKEYSLDTRGKFILSIAYSP--DGKY------LASGAIDGIINIFDIATGKLL-- 183

Query: 228 ELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTC 287
                 TL GH  P+ +  FS D Q+LV+ S D  + +YD    N+  TL+ H  +V   
Sbjct: 184 -----HTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNV 238

Query: 288 AFAPNTLLLATGSMDKTVNIWQFDLETLCQARRTEHQ 324
           AF P+     + S DK+V +W     T C     +HQ
Sbjct: 239 AFCPDDTHFVSSSSDKSVKVWDVGTRT-CVHTFFDHQ 274



 Score = 59.7 bits (143), Expect = 6e-09
 Identities = 50/187 (26%), Positives = 83/187 (44%), Gaps = 28/187 (14%)

Query: 150 NGSFFVTGSSCGDLTVW---DDKMRCLHSEKAHDLGITCCDFS-SQPVSDGEQGLQFFRL 205
           N    VTGS    + VW   D+++    S + H LG+   D S + P++         RL
Sbjct: 31  NSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRL 90

Query: 206 ASCGQDCQVK--------IWIVSFT---------------HILGFEL-KYKSTLSGHCAP 241
                  Q+K         W ++F+               +I G E  K + +L      
Sbjct: 91  WDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKF 150

Query: 242 VLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSM 301
           +L+ A+S DG+ L SG++D  + ++D  T  +LHTL  H   + +  F+P++ LL T S 
Sbjct: 151 ILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASD 210

Query: 302 DKTVNIW 308
           D  + I+
Sbjct: 211 DGYIKIY 217



 Score = 30.8 bits (68), Expect = 2.8
 Identities = 24/82 (29%), Positives = 34/82 (41%), Gaps = 4/82 (4%)

Query: 3   KLIHTLADHGDDVNCCAFS--FSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCC 60
           KL+HTL  H   +    FS    LL T S D  I++Y ++         L  H   V   
Sbjct: 181 KLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLA--GTLSGHASWVLNV 238

Query: 61  CFSPSGHILASCSTDGTTVLWN 82
            F P      S S+D +  +W+
Sbjct: 239 AFCPDDTHFVSSSSDKSVKVWD 260


>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
            sapiens]
          Length = 1205

 Score = 90.1 bits (222), Expect = 4e-18
 Identities = 90/354 (25%), Positives = 144/354 (40%), Gaps = 64/354 (18%)

Query: 3    KLIHTLADHGDDVNCCAFSFS----LLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVH 58
            +L+HT  +H + VNCC F+ S    LLAT S D  ++L+ L    +   + +  HT +V+
Sbjct: 690  ELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQ--KECRNTMFGHTNSVN 747

Query: 59   CCCFSPSGHILASCSTDGTTVLWNTENG---------QMLAVMEQPSGSP---VRVCQFS 106
             C FSP   +LASCS DGT  LW+  +          Q    +E P       V+ C +S
Sbjct: 748  HCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWS 807

Query: 107  PDSTCLASGAADGTVVLWNAQS-YKLYRCGSVKDGSLA---ACAFSPNGSFFVTGSSCGD 162
             D   +   AA   + LWN  S  K+  C     G L+      FSP+GS F+T S    
Sbjct: 808  ADGARIMV-AAKNKIFLWNTDSRSKVADC----RGHLSWVHGVMFSPDGSSFLTSSDDQT 862

Query: 163  LTVWDDKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFT 222
            + +W+ K  C +S               Q V    Q              + ++ +++  
Sbjct: 863  IRLWETKKVCKNS----------AVMLKQEVDVVFQ--------------ENEVMVLAVD 898

Query: 223  HILGFELKYKSTLSGHC--------APVLACAFSHDGQMLVSGSVDKSVIVYDTNTENIL 274
            HI   +L     ++G          A V  C  S   Q +  G  + ++ + +     I 
Sbjct: 899  HIRRLQL-----INGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIF 953

Query: 275  HTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFDLETLCQARRTEHQLKQF 328
             +  QH + V    F  +   L + S D  + +W + L+     R  +  +K F
Sbjct: 954  QSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDF 1007



 Score = 89.4 bits (220), Expect = 7e-18
 Identities = 69/279 (24%), Positives = 122/279 (43%), Gaps = 21/279 (7%)

Query: 40  RDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSP 99
           ++ T L    ++ HT AV+  CFS  G  +ASC  D T  ++  E G+ L  ++      
Sbjct: 601 KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHE-DE 659

Query: 100 VRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAF--SPNGSFFVTG 157
           V  C FS D   +A+ + D  V +WN+ + +L          +  C F  S +     TG
Sbjct: 660 VLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATG 719

Query: 158 SSCGDLTVWD-DKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKI 216
           SS   L +WD ++  C ++   H   +  C FS               LASC  D  +K+
Sbjct: 720 SSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDK----------LLASCSADGTLKL 769

Query: 217 WIVSFT------HILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNT 270
           W  +        ++  F L  +         V  C++S DG  ++  + +K + +++T++
Sbjct: 770 WDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLWNTDS 828

Query: 271 ENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQ 309
            + +     H  +V    F+P+     T S D+T+ +W+
Sbjct: 829 RSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 867



 Score = 62.8 bits (151), Expect = 7e-10
 Identities = 38/110 (34%), Positives = 60/110 (54%), Gaps = 9/110 (8%)

Query: 204 RLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSV 263
           R+ASCG D  ++++       L  E+K       H   VL CAFS D + + + SVDK V
Sbjct: 629 RIASCGADKTLQVFKAETGEKL-LEIK------AHEDEVLCCAFSTDDRFIATCSVDKKV 681

Query: 264 IVYDTNTENILHTLTQHTRYVTTCAFAPNT--LLLATGSMDKTVNIWQFD 311
            ++++ T  ++HT  +H+  V  C F  ++  LLLATGS D  + +W  +
Sbjct: 682 KIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 731



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 67/297 (22%), Positives = 110/297 (37%), Gaps = 64/297 (21%)

Query: 53   HTYAVHCCCFSPSGHILASCSTDGTTVLWNT--------------------ENGQMLAVM 92
            H   VH   FSP G    + S D T  LW T                    EN  M+  +
Sbjct: 838  HLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAV 897

Query: 93   EQP----------------SGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGS 136
            +                  + + V  C  SP    +A G  +G + +    + ++++   
Sbjct: 898  DHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRF 957

Query: 137  VKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM-RCL----HSEKAHDLGITCCDFSSQ 191
                ++    F+ +    ++ S   ++ VW+ ++ +C+    H E   D  +        
Sbjct: 958  QHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRL-------- 1009

Query: 192  PVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDG 251
                    L+  RL S   D  VK+W +    I G + K       H   VL+C  SHD 
Sbjct: 1010 --------LKNSRLLSWSFDGTVKVWNI----ITGNKEK---DFVCHQGTVLSCDISHDA 1054

Query: 252  QMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
                S S DK+  ++  +    LH L  H   V   AF+ ++ LLATG  +  + IW
Sbjct: 1055 TKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIW 1111



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 65/267 (24%), Positives = 105/267 (39%), Gaps = 42/267 (15%)

Query: 57   VHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGA 116
            V CCC SP    +A    +G   +    N ++     Q   +   + QF+ D   L S +
Sbjct: 921  VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHI-QFTADEKTLISSS 979

Query: 117  ADGTVVLWNAQSYK-LYRCG---SVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRC 172
             D  + +WN Q  K ++  G   +VKD  L         S  ++ S  G + VW+  +  
Sbjct: 980  DDAEIQVWNWQLDKCIFLRGHQETVKDFRLL------KNSRLLSWSFDGTVKVWN--IIT 1031

Query: 173  LHSEK---AHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFEL 229
             + EK    H   +  CD S              + +S   D   KIW  SF  +L    
Sbjct: 1032 GNKEKDFVCHQGTVLSCDISHDAT----------KFSSTSADKTAKIW--SFDLLLPLH- 1078

Query: 230  KYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHT--------LTQHT 281
                 L GH   V   AFS D  +L +G  +  + +++ +   +LH            H 
Sbjct: 1079 ----ELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHG 1134

Query: 282  RYVTTCAFAPN-TLLLATGSMDKTVNI 307
             +VT   F+P+  +L++ G   K  N+
Sbjct: 1135 GWVTDLCFSPDGKMLISAGGYIKWWNV 1161



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 45/159 (28%), Positives = 68/159 (42%), Gaps = 14/159 (8%)

Query: 14   DVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCS 73
            D++  A  FS   + S DKT +++S      LP   L+ H   V C  FS    +LA+  
Sbjct: 1049 DISHDATKFS---STSADKTAKIWSFDLL--LPLHELRGHNGCVRCSAFSVDSTLLATGD 1103

Query: 74   TDGTTVLWNTENGQMLAVMEQPS-------GSPVRVCQFSPDSTCLASGAADGTVVLWNA 126
             +G   +WN  NG++L +    S       G  V    FSPD   L S  A G +  WN 
Sbjct: 1104 DNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLIS--AGGYIKWWNV 1161

Query: 127  QSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTV 165
             + +  +       +L     SP+   +VT  + G L +
Sbjct: 1162 VTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYI 1200



 Score = 38.1 bits (87), Expect = 0.018
 Identities = 36/113 (31%), Positives = 51/113 (45%), Gaps = 13/113 (11%)

Query: 5    IHTLADHGDDVNCCAFSF--SLLATCSLDKTIRLYSLRDFTELPH--SPLKFHTYAVH-- 58
            +H L  H   V C AFS   +LLAT   +  IR++++ +  EL H  +PL     A H  
Sbjct: 1077 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN-GELLHLCAPLSEEGAATHGG 1135

Query: 59   ---CCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPD 108
                 CFSP G +L S    G    WN   G+        +G+ ++    SPD
Sbjct: 1136 WVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTF-YTNGTNLKKIHVSPD 1185


>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
           sapiens]
          Length = 1194

 Score = 90.1 bits (222), Expect = 4e-18
 Identities = 90/354 (25%), Positives = 144/354 (40%), Gaps = 64/354 (18%)

Query: 3   KLIHTLADHGDDVNCCAFSFS----LLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVH 58
           +L+HT  +H + VNCC F+ S    LLAT S D  ++L+ L    +   + +  HT +V+
Sbjct: 679 ELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQ--KECRNTMFGHTNSVN 736

Query: 59  CCCFSPSGHILASCSTDGTTVLWNTENG---------QMLAVMEQPSGSP---VRVCQFS 106
            C FSP   +LASCS DGT  LW+  +          Q    +E P       V+ C +S
Sbjct: 737 HCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWS 796

Query: 107 PDSTCLASGAADGTVVLWNAQS-YKLYRCGSVKDGSLA---ACAFSPNGSFFVTGSSCGD 162
            D   +   AA   + LWN  S  K+  C     G L+      FSP+GS F+T S    
Sbjct: 797 ADGARIMV-AAKNKIFLWNTDSRSKVADC----RGHLSWVHGVMFSPDGSSFLTSSDDQT 851

Query: 163 LTVWDDKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFT 222
           + +W+ K  C +S               Q V    Q              + ++ +++  
Sbjct: 852 IRLWETKKVCKNS----------AVMLKQEVDVVFQ--------------ENEVMVLAVD 887

Query: 223 HILGFELKYKSTLSGHC--------APVLACAFSHDGQMLVSGSVDKSVIVYDTNTENIL 274
           HI   +L     ++G          A V  C  S   Q +  G  + ++ + +     I 
Sbjct: 888 HIRRLQL-----INGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIF 942

Query: 275 HTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFDLETLCQARRTEHQLKQF 328
            +  QH + V    F  +   L + S D  + +W + L+     R  +  +K F
Sbjct: 943 QSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDF 996



 Score = 89.4 bits (220), Expect = 7e-18
 Identities = 69/279 (24%), Positives = 122/279 (43%), Gaps = 21/279 (7%)

Query: 40  RDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSP 99
           ++ T L    ++ HT AV+  CFS  G  +ASC  D T  ++  E G+ L  ++      
Sbjct: 590 KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHE-DE 648

Query: 100 VRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAF--SPNGSFFVTG 157
           V  C FS D   +A+ + D  V +WN+ + +L          +  C F  S +     TG
Sbjct: 649 VLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATG 708

Query: 158 SSCGDLTVWD-DKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKI 216
           SS   L +WD ++  C ++   H   +  C FS               LASC  D  +K+
Sbjct: 709 SSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDK----------LLASCSADGTLKL 758

Query: 217 WIVSFT------HILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNT 270
           W  +        ++  F L  +         V  C++S DG  ++  + +K + +++T++
Sbjct: 759 WDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLWNTDS 817

Query: 271 ENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQ 309
            + +     H  +V    F+P+     T S D+T+ +W+
Sbjct: 818 RSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 856



 Score = 62.8 bits (151), Expect = 7e-10
 Identities = 38/110 (34%), Positives = 60/110 (54%), Gaps = 9/110 (8%)

Query: 204 RLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSV 263
           R+ASCG D  ++++       L  E+K       H   VL CAFS D + + + SVDK V
Sbjct: 618 RIASCGADKTLQVFKAETGEKL-LEIK------AHEDEVLCCAFSTDDRFIATCSVDKKV 670

Query: 264 IVYDTNTENILHTLTQHTRYVTTCAFAPNT--LLLATGSMDKTVNIWQFD 311
            ++++ T  ++HT  +H+  V  C F  ++  LLLATGS D  + +W  +
Sbjct: 671 KIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 720



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 67/297 (22%), Positives = 110/297 (37%), Gaps = 64/297 (21%)

Query: 53   HTYAVHCCCFSPSGHILASCSTDGTTVLWNT--------------------ENGQMLAVM 92
            H   VH   FSP G    + S D T  LW T                    EN  M+  +
Sbjct: 827  HLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAV 886

Query: 93   EQP----------------SGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGS 136
            +                  + + V  C  SP    +A G  +G + +    + ++++   
Sbjct: 887  DHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRF 946

Query: 137  VKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM-RCL----HSEKAHDLGITCCDFSSQ 191
                ++    F+ +    ++ S   ++ VW+ ++ +C+    H E   D  +        
Sbjct: 947  QHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRL-------- 998

Query: 192  PVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDG 251
                    L+  RL S   D  VK+W +    I G + K       H   VL+C  SHD 
Sbjct: 999  --------LKNSRLLSWSFDGTVKVWNI----ITGNKEK---DFVCHQGTVLSCDISHDA 1043

Query: 252  QMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
                S S DK+  ++  +    LH L  H   V   AF+ ++ LLATG  +  + IW
Sbjct: 1044 TKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIW 1100



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 65/267 (24%), Positives = 105/267 (39%), Gaps = 42/267 (15%)

Query: 57   VHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGA 116
            V CCC SP    +A    +G   +    N ++     Q   +   + QF+ D   L S +
Sbjct: 910  VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHI-QFTADEKTLISSS 968

Query: 117  ADGTVVLWNAQSYK-LYRCG---SVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRC 172
             D  + +WN Q  K ++  G   +VKD  L         S  ++ S  G + VW+  +  
Sbjct: 969  DDAEIQVWNWQLDKCIFLRGHQETVKDFRLL------KNSRLLSWSFDGTVKVWN--IIT 1020

Query: 173  LHSEK---AHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFEL 229
             + EK    H   +  CD S              + +S   D   KIW  SF  +L    
Sbjct: 1021 GNKEKDFVCHQGTVLSCDISHDAT----------KFSSTSADKTAKIW--SFDLLLPLH- 1067

Query: 230  KYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHT--------LTQHT 281
                 L GH   V   AFS D  +L +G  +  + +++ +   +LH            H 
Sbjct: 1068 ----ELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHG 1123

Query: 282  RYVTTCAFAPN-TLLLATGSMDKTVNI 307
             +VT   F+P+  +L++ G   K  N+
Sbjct: 1124 GWVTDLCFSPDGKMLISAGGYIKWWNV 1150



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 45/159 (28%), Positives = 68/159 (42%), Gaps = 14/159 (8%)

Query: 14   DVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCS 73
            D++  A  FS   + S DKT +++S      LP   L+ H   V C  FS    +LA+  
Sbjct: 1038 DISHDATKFS---STSADKTAKIWSFDLL--LPLHELRGHNGCVRCSAFSVDSTLLATGD 1092

Query: 74   TDGTTVLWNTENGQMLAVMEQPS-------GSPVRVCQFSPDSTCLASGAADGTVVLWNA 126
             +G   +WN  NG++L +    S       G  V    FSPD   L S  A G +  WN 
Sbjct: 1093 DNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLIS--AGGYIKWWNV 1150

Query: 127  QSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTV 165
             + +  +       +L     SP+   +VT  + G L +
Sbjct: 1151 VTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYI 1189



 Score = 38.1 bits (87), Expect = 0.018
 Identities = 36/113 (31%), Positives = 51/113 (45%), Gaps = 13/113 (11%)

Query: 5    IHTLADHGDDVNCCAFSF--SLLATCSLDKTIRLYSLRDFTELPH--SPLKFHTYAVH-- 58
            +H L  H   V C AFS   +LLAT   +  IR++++ +  EL H  +PL     A H  
Sbjct: 1066 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN-GELLHLCAPLSEEGAATHGG 1124

Query: 59   ---CCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPD 108
                 CFSP G +L S    G    WN   G+        +G+ ++    SPD
Sbjct: 1125 WVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTF-YTNGTNLKKIHVSPD 1174


>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
           sapiens]
          Length = 472

 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 78/276 (28%), Positives = 125/276 (45%), Gaps = 28/276 (10%)

Query: 43  TELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRV 102
           +++P   L  H +AV  C F      L S S D T  LW+  +G ++   E    +PV  
Sbjct: 91  SKIPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVE 150

Query: 103 CQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVK-DGSLAACAFSPNGSFFVTGSSCG 161
           C  + DS+ + + + D TV  W+ ++ KL     V+ D  + +C FSP+G + V+G    
Sbjct: 151 CSITGDSSRVIAASYDKTVRAWDLETGKL--LWKVRYDTFIVSCKFSPDGKYVVSGFDVD 208

Query: 162 -DLTVWDDKMRCLHS--EKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWI 218
             + + D +     S  +  H   IT C F   P S         R+AS   D  +KIW 
Sbjct: 209 HGICIMDAENITTVSVIKDHHTRSITSCCF--DPDSQ--------RVASVSLDRCIKIWD 258

Query: 219 VSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILH--- 275
           V+    L       +    H   +  C F+  G  L + S DK++ +++ +T    +   
Sbjct: 259 VTSQATL------LTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGA 312

Query: 276 --TLTQ-HTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
             TL Q H   V++C FA ++  L +G  D+TV IW
Sbjct: 313 CVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIW 348



 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 78/318 (24%), Positives = 135/318 (42%), Gaps = 36/318 (11%)

Query: 8   LADHGDDVNCCAFSF--SLLATCSLDKTIRLYS------LRDFTELPHSPLKFHTYAVHC 59
           L+ H   V+ C F    + L + S D T++L+       +RDF   P +P+      V C
Sbjct: 98  LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPV------VEC 151

Query: 60  CCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGA-AD 118
                S  ++A+ S D T   W+ E G++L  +   +   +  C+FSPD   + SG   D
Sbjct: 152 SITGDSSRVIAA-SYDKTVRAWDLETGKLLWKVRYDTF--IVSCKFSPDGKYVVSGFDVD 208

Query: 119 GTVVLWNAQSYKLYRCGSVKDG---SLAACAFSPNGSFFVTGSSCGDLTVWD--DKMRCL 173
             + + +A++  +     +KD    S+ +C F P+     + S    + +WD   +   L
Sbjct: 209 HGICIMDAEN--ITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLL 266

Query: 174 HSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKS 233
              KAH   I+ C F+               L +   D  +KIW V             +
Sbjct: 267 TITKAHSNAISNCCFT----------FSGHFLCTSSWDKNLKIWNVHTGEFRNCGACV-T 315

Query: 234 TLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNT 293
            + GH   V +C F+ D   L+SG  D++V ++D        +L  H  +V   A + N 
Sbjct: 316 LMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNK 375

Query: 294 LLLATGSMDKTVNIWQFD 311
             + + S D+T+ +W  +
Sbjct: 376 KWILSASKDRTMRLWNIE 393


>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
           alpha subunit [Homo sapiens]
          Length = 410

 Score = 88.2 bits (217), Expect = 1e-17
 Identities = 81/319 (25%), Positives = 138/319 (43%), Gaps = 27/319 (8%)

Query: 6   HTLADHGDDVNCCAFS--FSLLATCSLDKTIRL--YSLRDFTELPHSPLKFHTYAVHCCC 61
           + L+ H   V    F   FS++ + S D TI++  Y   DF       LK HT +V    
Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERT----LKGHTDSVQDIS 157

Query: 62  FSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTV 121
           F  SG +LASCS D T  LW+ +  + +  M     +   V    P+   + S + D T+
Sbjct: 158 FDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVA-IMPNGDHIVSASRDKTI 216

Query: 122 VLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMR-CLHSEKAHD 180
            +W  Q+    +  +     +     + +G+   + S+   + VW    + C    + H+
Sbjct: 217 KMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHE 276

Query: 181 LGITCCD------FSSQPVSDGEQGLQFFR----LASCGQDCQVKIWIVSFTHILGFELK 230
             + C        +SS   + G +  +  +    L S  +D  +K+W VS    L     
Sbjct: 277 HVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCL----- 331

Query: 231 YKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFA 290
              TL GH   V    F   G+ ++S + DK++ V+D   +  + TL  H  +VT+  F 
Sbjct: 332 --MTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFH 389

Query: 291 PNTLLLATGSMDKTVNIWQ 309
                + TGS+D+TV +W+
Sbjct: 390 KTAPYVVTGSVDQTVKVWE 408



 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 70/289 (24%), Positives = 119/289 (41%), Gaps = 39/289 (13%)

Query: 45  LPHSPLKF----HTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPV 100
           +P  P K+    H   V    F P   ++ S S D T  +W+ E G     ++  + S V
Sbjct: 95  IPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDS-V 153

Query: 101 RVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSC 160
           +   F      LAS +AD T+ LW+ Q ++  R     D ++++ A  PNG   V+ S  
Sbjct: 154 QDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRD 213

Query: 161 GDLTVWDDKMR-CLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIV 219
             + +W+ +   C+ +   H   +       +P  DG        +ASC  D  V++W+V
Sbjct: 214 KTIKMWEVQTGYCVKTFTGHREWVRMV----RPNQDGTL------IASCSNDQTVRVWVV 263

Query: 220 SFTHILGFELKYKSTLSGHCAPVLACA------------------FSHDGQMLVSGSVDK 261
           +       E K +     H    ++ A                      G  L+SGS DK
Sbjct: 264 ATK-----ECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDK 318

Query: 262 SVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQF 310
           ++ ++D +T   L TL  H  +V    F      + + + DKT+ +W +
Sbjct: 319 TIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDY 367


>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
           sapiens]
          Length = 1248

 Score = 88.2 bits (217), Expect = 1e-17
 Identities = 71/282 (25%), Positives = 118/282 (41%), Gaps = 22/282 (7%)

Query: 40  RDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSP 99
           ++ T L    ++ HT AV+  CFS  G  +ASC  D T  ++  E G+ L  ++      
Sbjct: 601 KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHE-DE 659

Query: 100 VRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAF--SPNGSFFVTG 157
           V  C FS D   +A+ + D  V +WN+ + +L          +  C F  S +     TG
Sbjct: 660 VLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATG 719

Query: 158 SSCGDLTVWD-DKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKI 216
           SS   L +WD ++  C ++   H   +  C FS               LASC  D  +K+
Sbjct: 720 SSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDK----------LLASCSADGTLKL 769

Query: 217 WIVSFT------HILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNT 270
           W  +        ++  F L  +         V  C++S DG  ++  + +K + ++D +T
Sbjct: 770 WDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHT 828

Query: 271 ENILHTL-TQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFD 311
             +L  + T H   +  C F+P   L         V +W  D
Sbjct: 829 SGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTD 870



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 75/321 (23%), Positives = 133/321 (41%), Gaps = 46/321 (14%)

Query: 11  HGDDVNCCAFSFS--LLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHI 68
           H D V    FS     +A+C  DKT++++      +L    +K H   V CC FS     
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLE--IKAHEDEVLCCAFSTDDRF 671

Query: 69  LASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDS--TCLASGAADGTVVLWNA 126
           +A+CS D    +WN+  G+++   ++ S   V  C F+  S    LA+G++D  + LW+ 
Sbjct: 672 IATCSVDKKVKIWNSMTGELVHTYDEHS-EQVNCCHFTNSSHHLLLATGSSDCFLKLWDL 730

Query: 127 QSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDD-----------KMRCLHS 175
              +          S+  C FSP+     + S+ G L +WD            K   L+ 
Sbjct: 731 NQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNL 790

Query: 176 EKAH---DLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYK 232
           E      ++ + CC +S    +DG                  +I + +   I  F++   
Sbjct: 791 EDPQEDMEVIVKCCSWS----ADG-----------------ARIMVAAKNKIFLFDIHTS 829

Query: 233 STL----SGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCA 288
             L    +GH + +  C FS    + V       V +++T++ + +     H  +V    
Sbjct: 830 GLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVM 889

Query: 289 FAPNTLLLATGSMDKTVNIWQ 309
           F+P+     T S D+T+ +W+
Sbjct: 890 FSPDGSSFLTSSDDQTIRLWE 910



 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 79/277 (28%), Positives = 127/277 (45%), Gaps = 40/277 (14%)

Query: 11  HGDDVNCCAFSFS--LLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGH- 67
           H D+V CCAFS     +ATCS+DK +++++     EL H+    H+  V+CC F+ S H 
Sbjct: 656 HEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMT-GELVHT-YDEHSEQVNCCHFTNSSHH 713

Query: 68  -ILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNA 126
            +LA+ S+D    LW+    +    M   + S V  C+FSPD   LAS +ADGT+ LW+A
Sbjct: 714 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNS-VNHCRFSPDDKLLASCSADGTLKLWDA 772

Query: 127 QSYKLYRCGSVKDGSL-------------AACAFSPNGSFFVTGSSCGDLTVWDDKMRCL 173
            S    +  +VK   L               C++S +G+  +  +    + ++D     L
Sbjct: 773 TSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAK-NKIFLFDIHTSGL 831

Query: 174 HSE--KAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKY 231
             E    H   I  CDFS Q             + +  Q C V++W       +      
Sbjct: 832 LGEIHTGHHSTIQYCDFSPQ---------NHLAVVALSQYC-VELWNTDSRSKV------ 875

Query: 232 KSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDT 268
            +   GH + V    FS DG   ++ S D+++ +++T
Sbjct: 876 -ADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 911



 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 87/372 (23%), Positives = 149/372 (40%), Gaps = 57/372 (15%)

Query: 3    KLIHTLADHGDDVNCCAFSFS----LLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVH 58
            +L+HT  +H + VNCC F+ S    LLAT S D  ++L+ L    +   + +  HT +V+
Sbjct: 690  ELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQ--KECRNTMFGHTNSVN 747

Query: 59   CCCFSPSGHILASCSTDGTTVLWNTENG---------QMLAVMEQPSGSP---VRVCQFS 106
             C FSP   +LASCS DGT  LW+  +          Q    +E P       V+ C +S
Sbjct: 748  HCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWS 807

Query: 107  PDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDG---SLAACAFSPNGSFFVTGSSCGDL 163
             D   +   AA   + L++  +  L   G +  G   ++  C FSP     V   S   +
Sbjct: 808  ADGARIMV-AAKNKIFLFDIHTSGL--LGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCV 864

Query: 164  TVWDDKMRCL------HSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQV--- 214
             +W+   R        H    H + +   D SS   S  +Q ++ +      ++  V   
Sbjct: 865  ELWNTDSRSKVADCRGHLSWVHGV-MFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLK 923

Query: 215  ----------KIWIVSFTHILGFELKYKSTLSGHC--------APVLACAFSHDGQMLVS 256
                      ++ +++  HI   +L     ++G          A V  C  S   Q +  
Sbjct: 924  QEVDVVFQENEVMVLAVDHIRRLQL-----INGRTGQIDYLTEAQVSCCCLSPHLQYIAF 978

Query: 257  GSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFDLETLC 316
            G  + ++ + +     I  +  QH + V    F  +   L + S D  + +W + L+   
Sbjct: 979  GDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI 1038

Query: 317  QARRTEHQLKQF 328
              R  +  +K F
Sbjct: 1039 FLRGHQETVKDF 1050



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 78/347 (22%), Positives = 133/347 (38%), Gaps = 70/347 (20%)

Query: 5    IHTLADHGDDVNCCAFS-FSLLATCSLDK-TIRLYSLRDFTELPHSPLKFHTYAVHCCCF 62
            IHT   H   +  C FS  + LA  +L +  + L++    +++  +  + H   VH   F
Sbjct: 835  IHT--GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKV--ADCRGHLSWVHGVMF 890

Query: 63   SPSGHILASCSTDGTTVLWNT--------------------ENGQMLAVMEQP------- 95
            SP G    + S D T  LW T                    EN  M+  ++         
Sbjct: 891  SPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLIN 950

Query: 96   ---------SGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACA 146
                     + + V  C  SP    +A G  +G + +    + ++++       ++    
Sbjct: 951  GRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQ 1010

Query: 147  FSPNGSFFVTGSSCGDLTVWDDKM-RCL----HSEKAHDLGITCCDFSSQPVSDGEQGLQ 201
            F+ +    ++ S   ++ VW+ ++ +C+    H E   D  +                L+
Sbjct: 1011 FTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRL----------------LK 1054

Query: 202  FFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDK 261
              RL S   D  VK+W +    I G + K       H   VL+C  SHD     S S DK
Sbjct: 1055 NSRLLSWSFDGTVKVWNI----ITGNKEK---DFVCHQGTVLSCDISHDATKFSSTSADK 1107

Query: 262  SVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
            +  ++  +    LH L  H   V   AF+ ++ LLATG  +  + IW
Sbjct: 1108 TAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIW 1154



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 65/267 (24%), Positives = 105/267 (39%), Gaps = 42/267 (15%)

Query: 57   VHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGA 116
            V CCC SP    +A    +G   +    N ++     Q   +   + QF+ D   L S +
Sbjct: 964  VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHI-QFTADEKTLISSS 1022

Query: 117  ADGTVVLWNAQSYK-LYRCG---SVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRC 172
             D  + +WN Q  K ++  G   +VKD  L         S  ++ S  G + VW+  +  
Sbjct: 1023 DDAEIQVWNWQLDKCIFLRGHQETVKDFRLL------KNSRLLSWSFDGTVKVWN--IIT 1074

Query: 173  LHSEK---AHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFEL 229
             + EK    H   +  CD S              + +S   D   KIW  SF  +L    
Sbjct: 1075 GNKEKDFVCHQGTVLSCDISHDAT----------KFSSTSADKTAKIW--SFDLLLPLH- 1121

Query: 230  KYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHT--------LTQHT 281
                 L GH   V   AFS D  +L +G  +  + +++ +   +LH            H 
Sbjct: 1122 ----ELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHG 1177

Query: 282  RYVTTCAFAPN-TLLLATGSMDKTVNI 307
             +VT   F+P+  +L++ G   K  N+
Sbjct: 1178 GWVTDLCFSPDGKMLISAGGYIKWWNV 1204



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 59/298 (19%), Positives = 102/298 (34%), Gaps = 58/298 (19%)

Query: 53   HTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCL 112
            H   +  C FSP  H+     +     LWNT++   +A       S V    FSPD +  
Sbjct: 839  HHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHL-SWVHGVMFSPDGSSF 897

Query: 113  ASGAADGTVVLWNAQSY-------------------------------------KLYRCG 135
             + + D T+ LW  +                                       +  +  
Sbjct: 898  LTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQID 957

Query: 136  SVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD-DKMRCLHSEKAHDLGITCCDFSSQPVS 194
             + +  ++ C  SP+  +   G   G + + +    R   S   H   +    F++   +
Sbjct: 958  YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 1017

Query: 195  DGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQML 254
                      L S   D ++++W         ++L     L GH   V       + ++L
Sbjct: 1018 ----------LISSSDDAEIQVW--------NWQLDKCIFLRGHQETVKDFRLLKNSRLL 1059

Query: 255  VSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFDL 312
             S S D +V V++  T N       H   V +C  + +    ++ S DKT  IW FDL
Sbjct: 1060 -SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDL 1116



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 45/159 (28%), Positives = 68/159 (42%), Gaps = 14/159 (8%)

Query: 14   DVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCS 73
            D++  A  FS   + S DKT +++S      LP   L+ H   V C  FS    +LA+  
Sbjct: 1092 DISHDATKFS---STSADKTAKIWSFDLL--LPLHELRGHNGCVRCSAFSVDSTLLATGD 1146

Query: 74   TDGTTVLWNTENGQMLAVMEQPS-------GSPVRVCQFSPDSTCLASGAADGTVVLWNA 126
             +G   +WN  NG++L +    S       G  V    FSPD   L S  A G +  WN 
Sbjct: 1147 DNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLIS--AGGYIKWWNV 1204

Query: 127  QSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTV 165
             + +  +       +L     SP+   +VT  + G L +
Sbjct: 1205 VTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYI 1243



 Score = 38.1 bits (87), Expect = 0.018
 Identities = 36/113 (31%), Positives = 51/113 (45%), Gaps = 13/113 (11%)

Query: 5    IHTLADHGDDVNCCAFSF--SLLATCSLDKTIRLYSLRDFTELPH--SPLKFHTYAVH-- 58
            +H L  H   V C AFS   +LLAT   +  IR++++ +  EL H  +PL     A H  
Sbjct: 1120 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN-GELLHLCAPLSEEGAATHGG 1178

Query: 59   ---CCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPD 108
                 CFSP G +L S    G    WN   G+        +G+ ++    SPD
Sbjct: 1179 WVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTF-YTNGTNLKKIHVSPD 1228


>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
           sapiens]
          Length = 1237

 Score = 88.2 bits (217), Expect = 1e-17
 Identities = 71/282 (25%), Positives = 118/282 (41%), Gaps = 22/282 (7%)

Query: 40  RDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSP 99
           ++ T L    ++ HT AV+  CFS  G  +ASC  D T  ++  E G+ L  ++      
Sbjct: 590 KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHE-DE 648

Query: 100 VRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAF--SPNGSFFVTG 157
           V  C FS D   +A+ + D  V +WN+ + +L          +  C F  S +     TG
Sbjct: 649 VLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATG 708

Query: 158 SSCGDLTVWD-DKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKI 216
           SS   L +WD ++  C ++   H   +  C FS               LASC  D  +K+
Sbjct: 709 SSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDK----------LLASCSADGTLKL 758

Query: 217 WIVSFT------HILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNT 270
           W  +        ++  F L  +         V  C++S DG  ++  + +K + ++D +T
Sbjct: 759 WDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHT 817

Query: 271 ENILHTL-TQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFD 311
             +L  + T H   +  C F+P   L         V +W  D
Sbjct: 818 SGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTD 859



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 75/321 (23%), Positives = 133/321 (41%), Gaps = 46/321 (14%)

Query: 11  HGDDVNCCAFSFS--LLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHI 68
           H D V    FS     +A+C  DKT++++      +L    +K H   V CC FS     
Sbjct: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLE--IKAHEDEVLCCAFSTDDRF 660

Query: 69  LASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDS--TCLASGAADGTVVLWNA 126
           +A+CS D    +WN+  G+++   ++ S   V  C F+  S    LA+G++D  + LW+ 
Sbjct: 661 IATCSVDKKVKIWNSMTGELVHTYDEHS-EQVNCCHFTNSSHHLLLATGSSDCFLKLWDL 719

Query: 127 QSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDD-----------KMRCLHS 175
              +          S+  C FSP+     + S+ G L +WD            K   L+ 
Sbjct: 720 NQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNL 779

Query: 176 EKAH---DLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYK 232
           E      ++ + CC +S    +DG                  +I + +   I  F++   
Sbjct: 780 EDPQEDMEVIVKCCSWS----ADG-----------------ARIMVAAKNKIFLFDIHTS 818

Query: 233 STL----SGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCA 288
             L    +GH + +  C FS    + V       V +++T++ + +     H  +V    
Sbjct: 819 GLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVM 878

Query: 289 FAPNTLLLATGSMDKTVNIWQ 309
           F+P+     T S D+T+ +W+
Sbjct: 879 FSPDGSSFLTSSDDQTIRLWE 899



 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 79/277 (28%), Positives = 127/277 (45%), Gaps = 40/277 (14%)

Query: 11  HGDDVNCCAFSFS--LLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGH- 67
           H D+V CCAFS     +ATCS+DK +++++     EL H+    H+  V+CC F+ S H 
Sbjct: 645 HEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMT-GELVHT-YDEHSEQVNCCHFTNSSHH 702

Query: 68  -ILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNA 126
            +LA+ S+D    LW+    +    M   + S V  C+FSPD   LAS +ADGT+ LW+A
Sbjct: 703 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNS-VNHCRFSPDDKLLASCSADGTLKLWDA 761

Query: 127 QSYKLYRCGSVKDGSL-------------AACAFSPNGSFFVTGSSCGDLTVWDDKMRCL 173
            S    +  +VK   L               C++S +G+  +  +    + ++D     L
Sbjct: 762 TSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAK-NKIFLFDIHTSGL 820

Query: 174 HSE--KAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKY 231
             E    H   I  CDFS Q             + +  Q C V++W       +      
Sbjct: 821 LGEIHTGHHSTIQYCDFSPQ---------NHLAVVALSQYC-VELWNTDSRSKV------ 864

Query: 232 KSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDT 268
            +   GH + V    FS DG   ++ S D+++ +++T
Sbjct: 865 -ADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 900



 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 87/372 (23%), Positives = 149/372 (40%), Gaps = 57/372 (15%)

Query: 3    KLIHTLADHGDDVNCCAFSFS----LLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVH 58
            +L+HT  +H + VNCC F+ S    LLAT S D  ++L+ L    +   + +  HT +V+
Sbjct: 679  ELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQ--KECRNTMFGHTNSVN 736

Query: 59   CCCFSPSGHILASCSTDGTTVLWNTENG---------QMLAVMEQPSGSP---VRVCQFS 106
             C FSP   +LASCS DGT  LW+  +          Q    +E P       V+ C +S
Sbjct: 737  HCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWS 796

Query: 107  PDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDG---SLAACAFSPNGSFFVTGSSCGDL 163
             D   +   AA   + L++  +  L   G +  G   ++  C FSP     V   S   +
Sbjct: 797  ADGARIMV-AAKNKIFLFDIHTSGL--LGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCV 853

Query: 164  TVWDDKMRCL------HSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQV--- 214
             +W+   R        H    H + +   D SS   S  +Q ++ +      ++  V   
Sbjct: 854  ELWNTDSRSKVADCRGHLSWVHGV-MFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLK 912

Query: 215  ----------KIWIVSFTHILGFELKYKSTLSGHC--------APVLACAFSHDGQMLVS 256
                      ++ +++  HI   +L     ++G          A V  C  S   Q +  
Sbjct: 913  QEVDVVFQENEVMVLAVDHIRRLQL-----INGRTGQIDYLTEAQVSCCCLSPHLQYIAF 967

Query: 257  GSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFDLETLC 316
            G  + ++ + +     I  +  QH + V    F  +   L + S D  + +W + L+   
Sbjct: 968  GDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI 1027

Query: 317  QARRTEHQLKQF 328
              R  +  +K F
Sbjct: 1028 FLRGHQETVKDF 1039



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 78/347 (22%), Positives = 133/347 (38%), Gaps = 70/347 (20%)

Query: 5    IHTLADHGDDVNCCAFS-FSLLATCSLDK-TIRLYSLRDFTELPHSPLKFHTYAVHCCCF 62
            IHT   H   +  C FS  + LA  +L +  + L++    +++  +  + H   VH   F
Sbjct: 824  IHT--GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKV--ADCRGHLSWVHGVMF 879

Query: 63   SPSGHILASCSTDGTTVLWNT--------------------ENGQMLAVMEQP------- 95
            SP G    + S D T  LW T                    EN  M+  ++         
Sbjct: 880  SPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLIN 939

Query: 96   ---------SGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACA 146
                     + + V  C  SP    +A G  +G + +    + ++++       ++    
Sbjct: 940  GRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQ 999

Query: 147  FSPNGSFFVTGSSCGDLTVWDDKM-RCL----HSEKAHDLGITCCDFSSQPVSDGEQGLQ 201
            F+ +    ++ S   ++ VW+ ++ +C+    H E   D  +                L+
Sbjct: 1000 FTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRL----------------LK 1043

Query: 202  FFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDK 261
              RL S   D  VK+W +    I G + K       H   VL+C  SHD     S S DK
Sbjct: 1044 NSRLLSWSFDGTVKVWNI----ITGNKEK---DFVCHQGTVLSCDISHDATKFSSTSADK 1096

Query: 262  SVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
            +  ++  +    LH L  H   V   AF+ ++ LLATG  +  + IW
Sbjct: 1097 TAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIW 1143



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 65/267 (24%), Positives = 105/267 (39%), Gaps = 42/267 (15%)

Query: 57   VHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGA 116
            V CCC SP    +A    +G   +    N ++     Q   +   + QF+ D   L S +
Sbjct: 953  VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHI-QFTADEKTLISSS 1011

Query: 117  ADGTVVLWNAQSYK-LYRCG---SVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRC 172
             D  + +WN Q  K ++  G   +VKD  L         S  ++ S  G + VW+  +  
Sbjct: 1012 DDAEIQVWNWQLDKCIFLRGHQETVKDFRLL------KNSRLLSWSFDGTVKVWN--IIT 1063

Query: 173  LHSEK---AHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFEL 229
             + EK    H   +  CD S              + +S   D   KIW  SF  +L    
Sbjct: 1064 GNKEKDFVCHQGTVLSCDISHDAT----------KFSSTSADKTAKIW--SFDLLLPLH- 1110

Query: 230  KYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHT--------LTQHT 281
                 L GH   V   AFS D  +L +G  +  + +++ +   +LH            H 
Sbjct: 1111 ----ELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHG 1166

Query: 282  RYVTTCAFAPN-TLLLATGSMDKTVNI 307
             +VT   F+P+  +L++ G   K  N+
Sbjct: 1167 GWVTDLCFSPDGKMLISAGGYIKWWNV 1193



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 59/298 (19%), Positives = 102/298 (34%), Gaps = 58/298 (19%)

Query: 53   HTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCL 112
            H   +  C FSP  H+     +     LWNT++   +A       S V    FSPD +  
Sbjct: 828  HHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHL-SWVHGVMFSPDGSSF 886

Query: 113  ASGAADGTVVLWNAQSY-------------------------------------KLYRCG 135
             + + D T+ LW  +                                       +  +  
Sbjct: 887  LTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQID 946

Query: 136  SVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD-DKMRCLHSEKAHDLGITCCDFSSQPVS 194
             + +  ++ C  SP+  +   G   G + + +    R   S   H   +    F++   +
Sbjct: 947  YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 1006

Query: 195  DGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQML 254
                      L S   D ++++W         ++L     L GH   V       + ++L
Sbjct: 1007 ----------LISSSDDAEIQVW--------NWQLDKCIFLRGHQETVKDFRLLKNSRLL 1048

Query: 255  VSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFDL 312
             S S D +V V++  T N       H   V +C  + +    ++ S DKT  IW FDL
Sbjct: 1049 -SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDL 1105



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 45/159 (28%), Positives = 68/159 (42%), Gaps = 14/159 (8%)

Query: 14   DVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCS 73
            D++  A  FS   + S DKT +++S      LP   L+ H   V C  FS    +LA+  
Sbjct: 1081 DISHDATKFS---STSADKTAKIWSFDLL--LPLHELRGHNGCVRCSAFSVDSTLLATGD 1135

Query: 74   TDGTTVLWNTENGQMLAVMEQPS-------GSPVRVCQFSPDSTCLASGAADGTVVLWNA 126
             +G   +WN  NG++L +    S       G  V    FSPD   L S  A G +  WN 
Sbjct: 1136 DNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLIS--AGGYIKWWNV 1193

Query: 127  QSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTV 165
             + +  +       +L     SP+   +VT  + G L +
Sbjct: 1194 VTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYI 1232



 Score = 38.1 bits (87), Expect = 0.018
 Identities = 36/113 (31%), Positives = 51/113 (45%), Gaps = 13/113 (11%)

Query: 5    IHTLADHGDDVNCCAFSF--SLLATCSLDKTIRLYSLRDFTELPH--SPLKFHTYAVH-- 58
            +H L  H   V C AFS   +LLAT   +  IR++++ +  EL H  +PL     A H  
Sbjct: 1109 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN-GELLHLCAPLSEEGAATHGG 1167

Query: 59   ---CCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPD 108
                 CFSP G +L S    G    WN   G+        +G+ ++    SPD
Sbjct: 1168 WVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTF-YTNGTNLKKIHVSPD 1217


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 85/305 (27%), Positives = 133/305 (43%), Gaps = 43/305 (14%)

Query: 46  PHSPLKF----HTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVR 101
           P+  LKF    HT AV    FSP+G  LAS S D    +W   +G+    +   SG  + 
Sbjct: 33  PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI---SGHKLG 89

Query: 102 VCQ--FSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSS 159
           +    +S DS  L S + D T+ +W+  S K  +        +  C F+P  +  V+GS 
Sbjct: 90  ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149

Query: 160 CGDLTVWDDKM-RCLHSEKAHDLGITCCDFS---SQPVSDGEQGLQFFRLASCGQ----- 210
              + +WD K  +CL +  AH   ++   F+   S  VS    GL      + GQ     
Sbjct: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL 209

Query: 211 --DCQVKIWIVSFT----HILGFEL------------KYKSTLSGHCAPVLACAFSH--- 249
             D    +  V F+    +IL   L            K   T +GH      C F++   
Sbjct: 210 IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGH-KNEKYCIFANFSV 268

Query: 250 -DGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSM--DKTVN 306
             G+ +VSGS D  V +++  T+ I+  L  HT  V + A  P   ++A+ ++  DKT+ 
Sbjct: 269 TGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIK 328

Query: 307 IWQFD 311
           +W+ D
Sbjct: 329 LWKSD 333



 Score = 66.2 bits (160), Expect = 6e-11
 Identities = 46/173 (26%), Positives = 81/173 (46%), Gaps = 13/173 (7%)

Query: 3   KLIHTLADHGDDVNCCAFS--FSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCC 60
           K + TL  H + V CC F+   +L+ + S D+++R++ ++    L   P   H+  V   
Sbjct: 120 KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPA--HSDPVSAV 177

Query: 61  CFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGT 120
            F+  G ++ S S DG   +W+T +GQ L  +      PV   +FSP+   + +   D T
Sbjct: 178 HFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNT 237

Query: 121 VVLWNAQSYKLYRCGSVKDG--SLAACAFS----PNGSFFVTGSSCGDLTVWD 167
           + LW+   Y   +C     G  +   C F+      G + V+GS    + +W+
Sbjct: 238 LKLWD---YSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWN 287


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 85/305 (27%), Positives = 133/305 (43%), Gaps = 43/305 (14%)

Query: 46  PHSPLKF----HTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVR 101
           P+  LKF    HT AV    FSP+G  LAS S D    +W   +G+    +   SG  + 
Sbjct: 33  PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI---SGHKLG 89

Query: 102 VCQ--FSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSS 159
           +    +S DS  L S + D T+ +W+  S K  +        +  C F+P  +  V+GS 
Sbjct: 90  ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149

Query: 160 CGDLTVWDDKM-RCLHSEKAHDLGITCCDFS---SQPVSDGEQGLQFFRLASCGQ----- 210
              + +WD K  +CL +  AH   ++   F+   S  VS    GL      + GQ     
Sbjct: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL 209

Query: 211 --DCQVKIWIVSFT----HILGFEL------------KYKSTLSGHCAPVLACAFSH--- 249
             D    +  V F+    +IL   L            K   T +GH      C F++   
Sbjct: 210 IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGH-KNEKYCIFANFSV 268

Query: 250 -DGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSM--DKTVN 306
             G+ +VSGS D  V +++  T+ I+  L  HT  V + A  P   ++A+ ++  DKT+ 
Sbjct: 269 TGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIK 328

Query: 307 IWQFD 311
           +W+ D
Sbjct: 329 LWKSD 333



 Score = 66.2 bits (160), Expect = 6e-11
 Identities = 46/173 (26%), Positives = 81/173 (46%), Gaps = 13/173 (7%)

Query: 3   KLIHTLADHGDDVNCCAFS--FSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCC 60
           K + TL  H + V CC F+   +L+ + S D+++R++ ++    L   P   H+  V   
Sbjct: 120 KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPA--HSDPVSAV 177

Query: 61  CFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGT 120
            F+  G ++ S S DG   +W+T +GQ L  +      PV   +FSP+   + +   D T
Sbjct: 178 HFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNT 237

Query: 121 VVLWNAQSYKLYRCGSVKDG--SLAACAFS----PNGSFFVTGSSCGDLTVWD 167
           + LW+   Y   +C     G  +   C F+      G + V+GS    + +W+
Sbjct: 238 LKLWD---YSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWN 287


>gi|21536371 telomerase-associated protein 1 [Homo sapiens]
          Length = 2627

 Score = 86.7 bits (213), Expect = 4e-17
 Identities = 83/305 (27%), Positives = 135/305 (44%), Gaps = 29/305 (9%)

Query: 19   AFSFSLLATCSLDKTIRLYSLRDFTELPH--------SPLKFHTYAVHCCCFSPSGHILA 70
            A S  LLA+ S D T++L+  R     PH        + L+ H   V CC FS  G  LA
Sbjct: 2019 ATSQELLASASEDFTVQLWP-RQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLA 2077

Query: 71   SCSTDGTTVLWNTENGQMLAVMEQPSGSP---VRVCQFSPDSTCLASGAADGTVVLWNAQ 127
            +   D + + W+    +   ++          V  C ++ D+  L S ++DG+V LW+ +
Sbjct: 2078 TGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDNL-LISCSSDGSVGLWDPE 2136

Query: 128  SYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHDLGITCCD 187
            S +  R G       A  A +      V+ S  G L VWD +   L S  AH   I+ C 
Sbjct: 2137 SGQ--RLGQFLGHQSAVSAVAAVEEHVVSVSRDGTLKVWDHQGVELTSIPAHSGPISHCA 2194

Query: 188  FSSQPVSDGEQGLQFFRLASCGQDCQVKIW---IVSFTHILGFELKYKSTLSGHCAPVLA 244
             + +P + G+ G +   + + G D   ++W   +V  TH          TL GH  PV A
Sbjct: 2195 AAMEPRAAGQPGSELL-VVTVGLDGATRLWHPLLVCQTH----------TLLGHSGPVRA 2243

Query: 245  CAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKT 304
             A S    ++++ S D SV ++    E     + + +  VT  A+AP+  +  +G+    
Sbjct: 2244 AAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSAAVTAVAWAPDGSMAVSGNQAGE 2303

Query: 305  VNIWQ 309
            + +WQ
Sbjct: 2304 LILWQ 2308



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 81/317 (25%), Positives = 134/317 (42%), Gaps = 25/317 (7%)

Query: 2    VKLIHTLADHGDDVNCCAFSF--SLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHC 59
            +K+   L   G  +   AF+    ++A   LD  + L++ R+   L   P   H   V  
Sbjct: 1832 LKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPA--HHGFVAA 1889

Query: 60   CCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADG 119
              F  +G  L +   DG   +W+   G+    +   S SP      SPD   +A G    
Sbjct: 1890 ALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGHLGSLSLSPALSVALSPDGDRVAVGYRAD 1949

Query: 120  TVVLWNAQSYKLYRCGSVKDGSLAACAF-SPNGSFFVTGSSCGDLTVWDDKMRCLHSEKA 178
             + ++   S      G   D +++A A+ SP     V+G+  G L  W  K   L S   
Sbjct: 1950 GIRIYKISSGSQGAQGQALDVAVSALAWLSP--KVLVSGAEDGSLQGWALKECSLQS--- 2004

Query: 179  HDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIW---IVSFTHILGFELKYKSTL 235
                +       +PV       +   LAS  +D  V++W   +++  H    +    + L
Sbjct: 2005 ----LWLLSRFQKPVLGLATSQEL--LASASEDFTVQLWPRQLLTRPH-KAEDFPCGTEL 2057

Query: 236  SGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTEN---ILHTLTQ-HTRYVTTCAFAP 291
             GH  PV  C+FS DG  L +G  D+S++ +D  T     ++H+    H  +VT CA+  
Sbjct: 2058 RGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTK 2117

Query: 292  NTLLLATGSMDKTVNIW 308
            + LL++  S D +V +W
Sbjct: 2118 DNLLISCSS-DGSVGLW 2133



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 63/257 (24%), Positives = 104/257 (40%), Gaps = 24/257 (9%)

Query: 13   DDVNCCAF-SFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILAS 71
            D ++ C F S   L   + D  + L+ L+    +  +  K H Y +  CC SP   +LA+
Sbjct: 1719 DGISACLFLSDDTLFLTAFDGLLELWDLQHGCRVLQT--KAHQYQITGCCLSPDCRLLAT 1776

Query: 72   CSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKL 131
                G   LW+T  GQ+      P    +    F P+   +A+G+  G++  +     K+
Sbjct: 1777 VCLGGCLKLWDTVRGQLAFQHTYPKS--LNCVAFHPEGQVIATGSWAGSISFFQVDGLKV 1834

Query: 132  YRCGSVKDGSLAACAFSPNGSFFVTG--SSCGDLTVWDDKMRCLHSEKAHDLGITCCDFS 189
             +       S+   AF+  G     G   S  +L  W +  R L +  AH   +    F 
Sbjct: 1835 TKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWREGAR-LAAFPAHHGFVAAALFL 1893

Query: 190  SQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSH 249
                     G Q   L + G+D +V++W  S    LG    +  +LS   +P L+ A S 
Sbjct: 1894 -------HAGCQ---LLTAGEDGKVQVWSGS----LGRPRGHLGSLS--LSPALSVALSP 1937

Query: 250  DGQMLVSGSVDKSVIVY 266
            DG  +  G     + +Y
Sbjct: 1938 DGDRVAVGYRADGIRIY 1954



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 58/227 (25%), Positives = 98/227 (43%), Gaps = 23/227 (10%)

Query: 84   ENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLA 143
            +N Q  ++    S SP  V  FS +    A G A+GTV L + ++++  +        ++
Sbjct: 1664 KNQQSSSLSLAVSSSPTAVA-FSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGIS 1722

Query: 144  ACAFSPNGSFFVTGSSCGDLTVWDDKMRC-LHSEKAHDLGIT-CCDFSSQPVSDGEQGLQ 201
            AC F  + + F+T    G L +WD +  C +   KAH   IT CC      +S   + L 
Sbjct: 1723 ACLFLSDDTLFLTAFD-GLLELWDLQHGCRVLQTKAHQYQITGCC------LSPDCRLLA 1775

Query: 202  FFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDK 261
               L  C     +K+W  +    L F+  Y  +L+         AF  +GQ++ +GS   
Sbjct: 1776 TVCLGGC-----LKLWD-TVRGQLAFQHTYPKSLN-------CVAFHPEGQVIATGSWAG 1822

Query: 262  SVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
            S+  +  +   +   L      + T AF     ++A G +D  V +W
Sbjct: 1823 SISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELW 1869



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 28/101 (27%), Positives = 47/101 (46%), Gaps = 1/101 (0%)

Query: 68   ILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQ 127
            ++ +   DG T LW+         +   SG PVR    S  S  + + + DG+V LW   
Sbjct: 2210 LVVTVGLDGATRLWHPLLVCQTHTLLGHSG-PVRAAAVSETSGLMLTASEDGSVRLWQVP 2268

Query: 128  SYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDD 168
                  C      ++ A A++P+GS  V+G+  G+L +W +
Sbjct: 2269 KEADDTCIPRSSAAVTAVAWAPDGSMAVSGNQAGELILWQE 2309



 Score = 29.6 bits (65), Expect = 6.3
 Identities = 42/181 (23%), Positives = 73/181 (40%), Gaps = 38/181 (20%)

Query: 141  SLAACAFSPNGSFFVTGSSCG-----DLTVWDDKMRCLHSEKAHDLGITCCDFSSQPVSD 195
            S  A AFS NG     G++ G     DL  W ++   +        GI+ C F    +SD
Sbjct: 1678 SPTAVAFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCD----GISACLF----LSD 1729

Query: 196  GEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTL---SGHCAPVLACAFSHDGQ 252
                L  F       D  +++W          +L++   +     H   +  C  S D +
Sbjct: 1730 DTLFLTAF-------DGLLELW----------DLQHGCRVLQTKAHQYQITGCCLSPDCR 1772

Query: 253  MLVSGSVDKSVIVYDTNTENILHTLTQHT--RYVTTCAFAPNTLLLATGSMDKTVNIWQF 310
            +L +  +   + ++DT    +     QHT  + +   AF P   ++ATGS   +++ +Q 
Sbjct: 1773 LLATVCLGGCLKLWDTVRGQLAF---QHTYPKSLNCVAFHPEGQVIATGSWAGSISFFQV 1829

Query: 311  D 311
            D
Sbjct: 1830 D 1830


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score = 86.7 bits (213), Expect = 4e-17
 Identities = 82/304 (26%), Positives = 129/304 (42%), Gaps = 40/304 (13%)

Query: 44  ELPHSP-------LKFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPS 96
           E+P +P       L  HT AV    FSP+G  LAS S D   ++W   +G+    +    
Sbjct: 24  EVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTL-YGH 82

Query: 97  GSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVT 156
              +    +S DS+ L S + D T+ LW+ +S K  +        +  C F+P  +  ++
Sbjct: 83  NLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIIS 142

Query: 157 GSSCGDLTVWDDKM-RCLHSEKAHDLGITCCDFS---SQPVSDGEQGLQFFRLASCGQ-- 210
           GS    + +W+ K  +CL +  AH   ++   F+   S  VS    GL     A+ GQ  
Sbjct: 143 GSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCL 202

Query: 211 -----DCQVKIWIVSF--------THILGFELKYKSTLSGHCAPVLA-------CAFSH- 249
                D    +  V F        T  L   LK      G C            C F++ 
Sbjct: 203 KTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANF 262

Query: 250 ---DGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSM--DKT 304
               G+ +VSGS D  V +++  T+ I+  L  HT  V + A  P   L+A+ ++  DKT
Sbjct: 263 SVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKT 322

Query: 305 VNIW 308
           + +W
Sbjct: 323 IKLW 326



 Score = 83.6 bits (205), Expect = 4e-16
 Identities = 65/227 (28%), Positives = 105/227 (46%), Gaps = 20/227 (8%)

Query: 104 QFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDL 163
           +FSP+   LAS +AD  +++W A   K  +     +  ++  A+S + S  V+ S    L
Sbjct: 48  KFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTL 107

Query: 164 TVWDDKM-RCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFT 222
            +WD +  +CL + K H   + CC+F+  P S+         + S   D  VKIW V   
Sbjct: 108 KLWDVRSGKCLKTLKGHSNYVFCCNFN--PPSN--------LIISGSFDETVKIWEVKTG 157

Query: 223 HILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTR 282
             L        TLS H  PV A  F+  G ++VSGS D    ++D  +   L TL     
Sbjct: 158 KCL-------KTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDN 210

Query: 283 Y-VTTCAFAPNTLLLATGSMDKTVNIWQFDLETLCQARRTEHQLKQF 328
             V+   F+PN   + T ++D T+ +W +     C    T H+ +++
Sbjct: 211 PPVSFVKFSPNGKYILTATLDNTLKLWDYS-RGRCLKTYTGHKNEKY 256



 Score = 66.2 bits (160), Expect = 6e-11
 Identities = 47/173 (27%), Positives = 81/173 (46%), Gaps = 13/173 (7%)

Query: 3   KLIHTLADHGDDVNCCAFS--FSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCC 60
           K + TL  H + V CC F+   +L+ + S D+T++++ ++    L    L  H+  V   
Sbjct: 116 KCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCL--KTLSAHSDPVSAV 173

Query: 61  CFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGT 120
            F+ SG ++ S S DG   +W+  +GQ L  +      PV   +FSP+   + +   D T
Sbjct: 174 HFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNT 233

Query: 121 VVLWNAQSYKLYRCGSVKDG--SLAACAFS----PNGSFFVTGSSCGDLTVWD 167
           + LW+   Y   RC     G  +   C F+      G + V+GS    + +W+
Sbjct: 234 LKLWD---YSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWN 283



 Score = 35.0 bits (79), Expect = 0.15
 Identities = 19/57 (33%), Positives = 31/57 (54%)

Query: 252 QMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
           Q+ +S S ++S  V +     +  TL  HT  V++  F+PN   LA+ S D+ + IW
Sbjct: 12  QLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIW 68


>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
           sapiens]
          Length = 589

 Score = 83.2 bits (204), Expect = 5e-16
 Identities = 70/255 (27%), Positives = 108/255 (42%), Gaps = 31/255 (12%)

Query: 61  CFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGT 120
           C    G+ + S S D T  +W+   G+ L  +   +G    V         + SG+ D T
Sbjct: 268 CLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG---VWSSQMRDNIIISGSTDRT 324

Query: 121 VVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD-DKMRCLHSEKAH 179
           + +WNA++ +     ++   +        +    V+GS    L VWD +  +CLH    H
Sbjct: 325 LKVWNAETGECIH--TLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGH 382

Query: 180 DLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHC 239
              + C  +  +            R+ S   D  VK+W       L        TL GH 
Sbjct: 383 VAAVRCVQYDGR------------RVVSGAYDFMVKVWDPETETCL-------HTLQGHT 423

Query: 240 APVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATG 299
             V +  F  DG  +VSGS+D S+ V+D  T N +HTLT H    +      N  +L +G
Sbjct: 424 NRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSG 479

Query: 300 SMDKTVNIWQFDLET 314
           + D TV IW  D++T
Sbjct: 480 NADSTVKIW--DIKT 492



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 59/215 (27%), Positives = 97/215 (45%), Gaps = 29/215 (13%)

Query: 112 LASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM- 170
           + SG+ D T+ +W+A + K  R      G + +     N    ++GS+   L VW+ +  
Sbjct: 276 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETG 333

Query: 171 RCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELK 230
            C+H+   H   + C     +            R+ S  +D  +++W +     L     
Sbjct: 334 ECIHTLYGHTSTVRCMHLHEK------------RVVSGSRDATLRVWDIETGQCL----- 376

Query: 231 YKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFA 290
               L GH A V    +  DG+ +VSG+ D  V V+D  TE  LHTL  HT  V +  F 
Sbjct: 377 --HVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF- 431

Query: 291 PNTLLLATGSMDKTVNIWQFDLET-LCQARRTEHQ 324
            + + + +GS+D ++ +W  D+ET  C    T HQ
Sbjct: 432 -DGIHVVSGSLDTSIRVW--DVETGNCIHTLTGHQ 463



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 84/313 (26%), Positives = 132/313 (42%), Gaps = 41/313 (13%)

Query: 8   LADHGDDV-NCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSG 66
           L  H D V  C  F  + + + S D T++++S    T      L  HT  V         
Sbjct: 258 LKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSA--VTGKCLRTLVGHTGGVWSS--QMRD 313

Query: 67  HILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNA 126
           +I+ S STD T  +WN E G+ +  +   + S VR          + SG+ D T+ +W+ 
Sbjct: 314 NIIISGSTDRTLKVWNAETGECIHTLYGHT-STVRCMHLHEKR--VVSGSRDATLRVWDI 370

Query: 127 QSYKLYRCGSVKDGSLAAC-AFSPNGSFFVTGSSCGDLTVWDDKMR-CLHSEKAHDLGIT 184
           ++ +   C  V  G +AA      +G   V+G+    + VWD +   CLH+ + H   + 
Sbjct: 371 ETGQ---CLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 427

Query: 185 CCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLA 244
              F    V  G              D  +++W V   + +        TL+GH +  L 
Sbjct: 428 SLQFDGIHVVSGSL------------DTSIRVWDVETGNCI-------HTLTGHQS--LT 466

Query: 245 CAFSHDGQMLVSGSVDKSVIVYDTNTENILHTL---TQHTRYVTTCAFAPNTLLLATGSM 301
                   +LVSG+ D +V ++D  T   L TL    +H   VT   F  N ++  T S 
Sbjct: 467 SGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVI--TSSD 524

Query: 302 DKTVNIWQFDLET 314
           D TV +W  DL+T
Sbjct: 525 DGTVKLW--DLKT 535



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 42/189 (22%), Positives = 74/189 (39%), Gaps = 13/189 (6%)

Query: 5   IHTLADHGDDVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSP 64
           IHTL  H   V C       + + S D T+R++ +   T      L  H  AV C  +  
Sbjct: 336 IHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIE--TGQCLHVLMGHVAAVRCVQY-- 391

Query: 65  SGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLW 124
            G  + S + D    +W+ E    L  ++   G   RV     D   + SG+ D ++ +W
Sbjct: 392 DGRRVVSGAYDFMVKVWDPETETCLHTLQ---GHTNRVYSLQFDGIHVVSGSLDTSIRVW 448

Query: 125 NAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDK----MRCLHSEKAHD 180
           + ++       +      +      N    V+G++   + +WD K    ++ L     H 
Sbjct: 449 DVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQ 506

Query: 181 LGITCCDFS 189
             +TC  F+
Sbjct: 507 SAVTCLQFN 515



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 33/132 (25%), Positives = 58/132 (43%), Gaps = 10/132 (7%)

Query: 5   IHTLADHGDDVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSP 64
           +HTL  H + V    F    + + SLD +IR++ +     +       HT   H    S 
Sbjct: 416 LHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCI-------HTLTGHQSLTSG 468

Query: 65  ---SGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTV 121
                +IL S + D T  +W+ + GQ L  ++ P+     V     +   + + + DGTV
Sbjct: 469 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV 528

Query: 122 VLWNAQSYKLYR 133
            LW+ ++ +  R
Sbjct: 529 KLWDLKTGEFIR 540


>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
           sapiens]
          Length = 707

 Score = 83.2 bits (204), Expect = 5e-16
 Identities = 70/255 (27%), Positives = 108/255 (42%), Gaps = 31/255 (12%)

Query: 61  CFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGT 120
           C    G+ + S S D T  +W+   G+ L  +   +G    V         + SG+ D T
Sbjct: 386 CLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG---VWSSQMRDNIIISGSTDRT 442

Query: 121 VVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD-DKMRCLHSEKAH 179
           + +WNA++ +     ++   +        +    V+GS    L VWD +  +CLH    H
Sbjct: 443 LKVWNAETGECIH--TLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGH 500

Query: 180 DLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHC 239
              + C  +  +            R+ S   D  VK+W       L        TL GH 
Sbjct: 501 VAAVRCVQYDGR------------RVVSGAYDFMVKVWDPETETCL-------HTLQGHT 541

Query: 240 APVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATG 299
             V +  F  DG  +VSGS+D S+ V+D  T N +HTLT H    +      N  +L +G
Sbjct: 542 NRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSG 597

Query: 300 SMDKTVNIWQFDLET 314
           + D TV IW  D++T
Sbjct: 598 NADSTVKIW--DIKT 610



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 59/215 (27%), Positives = 97/215 (45%), Gaps = 29/215 (13%)

Query: 112 LASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM- 170
           + SG+ D T+ +W+A + K  R      G + +     N    ++GS+   L VW+ +  
Sbjct: 394 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETG 451

Query: 171 RCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELK 230
            C+H+   H   + C     +            R+ S  +D  +++W +     L     
Sbjct: 452 ECIHTLYGHTSTVRCMHLHEK------------RVVSGSRDATLRVWDIETGQCL----- 494

Query: 231 YKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFA 290
               L GH A V    +  DG+ +VSG+ D  V V+D  TE  LHTL  HT  V +  F 
Sbjct: 495 --HVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF- 549

Query: 291 PNTLLLATGSMDKTVNIWQFDLET-LCQARRTEHQ 324
            + + + +GS+D ++ +W  D+ET  C    T HQ
Sbjct: 550 -DGIHVVSGSLDTSIRVW--DVETGNCIHTLTGHQ 581



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 84/313 (26%), Positives = 132/313 (42%), Gaps = 41/313 (13%)

Query: 8   LADHGDDV-NCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSG 66
           L  H D V  C  F  + + + S D T++++S    T      L  HT  V         
Sbjct: 376 LKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSA--VTGKCLRTLVGHTGGVWSS--QMRD 431

Query: 67  HILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNA 126
           +I+ S STD T  +WN E G+ +  +   + S VR          + SG+ D T+ +W+ 
Sbjct: 432 NIIISGSTDRTLKVWNAETGECIHTLYGHT-STVRCMHLHEKR--VVSGSRDATLRVWDI 488

Query: 127 QSYKLYRCGSVKDGSLAAC-AFSPNGSFFVTGSSCGDLTVWDDKMR-CLHSEKAHDLGIT 184
           ++ +   C  V  G +AA      +G   V+G+    + VWD +   CLH+ + H   + 
Sbjct: 489 ETGQ---CLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 545

Query: 185 CCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLA 244
              F    V  G              D  +++W V   + +        TL+GH +  L 
Sbjct: 546 SLQFDGIHVVSGSL------------DTSIRVWDVETGNCI-------HTLTGHQS--LT 584

Query: 245 CAFSHDGQMLVSGSVDKSVIVYDTNTENILHTL---TQHTRYVTTCAFAPNTLLLATGSM 301
                   +LVSG+ D +V ++D  T   L TL    +H   VT   F  N ++  T S 
Sbjct: 585 SGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVI--TSSD 642

Query: 302 DKTVNIWQFDLET 314
           D TV +W  DL+T
Sbjct: 643 DGTVKLW--DLKT 653



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 42/189 (22%), Positives = 74/189 (39%), Gaps = 13/189 (6%)

Query: 5   IHTLADHGDDVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSP 64
           IHTL  H   V C       + + S D T+R++ +   T      L  H  AV C  +  
Sbjct: 454 IHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIE--TGQCLHVLMGHVAAVRCVQY-- 509

Query: 65  SGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLW 124
            G  + S + D    +W+ E    L  ++   G   RV     D   + SG+ D ++ +W
Sbjct: 510 DGRRVVSGAYDFMVKVWDPETETCLHTLQ---GHTNRVYSLQFDGIHVVSGSLDTSIRVW 566

Query: 125 NAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDK----MRCLHSEKAHD 180
           + ++       +      +      N    V+G++   + +WD K    ++ L     H 
Sbjct: 567 DVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQ 624

Query: 181 LGITCCDFS 189
             +TC  F+
Sbjct: 625 SAVTCLQFN 633



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 33/132 (25%), Positives = 58/132 (43%), Gaps = 10/132 (7%)

Query: 5   IHTLADHGDDVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSP 64
           +HTL  H + V    F    + + SLD +IR++ +     +       HT   H    S 
Sbjct: 534 LHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCI-------HTLTGHQSLTSG 586

Query: 65  ---SGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTV 121
                +IL S + D T  +W+ + GQ L  ++ P+     V     +   + + + DGTV
Sbjct: 587 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV 646

Query: 122 VLWNAQSYKLYR 133
            LW+ ++ +  R
Sbjct: 647 KLWDLKTGEFIR 658


>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
           sapiens]
          Length = 627

 Score = 83.2 bits (204), Expect = 5e-16
 Identities = 70/255 (27%), Positives = 108/255 (42%), Gaps = 31/255 (12%)

Query: 61  CFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGT 120
           C    G+ + S S D T  +W+   G+ L  +   +G    V         + SG+ D T
Sbjct: 306 CLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG---VWSSQMRDNIIISGSTDRT 362

Query: 121 VVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD-DKMRCLHSEKAH 179
           + +WNA++ +     ++   +        +    V+GS    L VWD +  +CLH    H
Sbjct: 363 LKVWNAETGECIH--TLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGH 420

Query: 180 DLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHC 239
              + C  +  +            R+ S   D  VK+W       L        TL GH 
Sbjct: 421 VAAVRCVQYDGR------------RVVSGAYDFMVKVWDPETETCL-------HTLQGHT 461

Query: 240 APVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATG 299
             V +  F  DG  +VSGS+D S+ V+D  T N +HTLT H    +      N  +L +G
Sbjct: 462 NRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSG 517

Query: 300 SMDKTVNIWQFDLET 314
           + D TV IW  D++T
Sbjct: 518 NADSTVKIW--DIKT 530



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 59/215 (27%), Positives = 97/215 (45%), Gaps = 29/215 (13%)

Query: 112 LASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM- 170
           + SG+ D T+ +W+A + K  R      G + +     N    ++GS+   L VW+ +  
Sbjct: 314 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETG 371

Query: 171 RCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELK 230
            C+H+   H   + C     +            R+ S  +D  +++W +     L     
Sbjct: 372 ECIHTLYGHTSTVRCMHLHEK------------RVVSGSRDATLRVWDIETGQCL----- 414

Query: 231 YKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFA 290
               L GH A V    +  DG+ +VSG+ D  V V+D  TE  LHTL  HT  V +  F 
Sbjct: 415 --HVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF- 469

Query: 291 PNTLLLATGSMDKTVNIWQFDLET-LCQARRTEHQ 324
            + + + +GS+D ++ +W  D+ET  C    T HQ
Sbjct: 470 -DGIHVVSGSLDTSIRVW--DVETGNCIHTLTGHQ 501



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 84/313 (26%), Positives = 132/313 (42%), Gaps = 41/313 (13%)

Query: 8   LADHGDDV-NCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSG 66
           L  H D V  C  F  + + + S D T++++S    T      L  HT  V         
Sbjct: 296 LKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSA--VTGKCLRTLVGHTGGVWSS--QMRD 351

Query: 67  HILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNA 126
           +I+ S STD T  +WN E G+ +  +   + S VR          + SG+ D T+ +W+ 
Sbjct: 352 NIIISGSTDRTLKVWNAETGECIHTLYGHT-STVRCMHLHEKR--VVSGSRDATLRVWDI 408

Query: 127 QSYKLYRCGSVKDGSLAAC-AFSPNGSFFVTGSSCGDLTVWDDKMR-CLHSEKAHDLGIT 184
           ++ +   C  V  G +AA      +G   V+G+    + VWD +   CLH+ + H   + 
Sbjct: 409 ETGQ---CLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 465

Query: 185 CCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLA 244
              F    V  G              D  +++W V   + +        TL+GH +  L 
Sbjct: 466 SLQFDGIHVVSGSL------------DTSIRVWDVETGNCI-------HTLTGHQS--LT 504

Query: 245 CAFSHDGQMLVSGSVDKSVIVYDTNTENILHTL---TQHTRYVTTCAFAPNTLLLATGSM 301
                   +LVSG+ D +V ++D  T   L TL    +H   VT   F  N ++  T S 
Sbjct: 505 SGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVI--TSSD 562

Query: 302 DKTVNIWQFDLET 314
           D TV +W  DL+T
Sbjct: 563 DGTVKLW--DLKT 573



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 42/189 (22%), Positives = 74/189 (39%), Gaps = 13/189 (6%)

Query: 5   IHTLADHGDDVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSP 64
           IHTL  H   V C       + + S D T+R++ +   T      L  H  AV C  +  
Sbjct: 374 IHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIE--TGQCLHVLMGHVAAVRCVQY-- 429

Query: 65  SGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLW 124
            G  + S + D    +W+ E    L  ++   G   RV     D   + SG+ D ++ +W
Sbjct: 430 DGRRVVSGAYDFMVKVWDPETETCLHTLQ---GHTNRVYSLQFDGIHVVSGSLDTSIRVW 486

Query: 125 NAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDK----MRCLHSEKAHD 180
           + ++       +      +      N    V+G++   + +WD K    ++ L     H 
Sbjct: 487 DVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQ 544

Query: 181 LGITCCDFS 189
             +TC  F+
Sbjct: 545 SAVTCLQFN 553



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 33/132 (25%), Positives = 58/132 (43%), Gaps = 10/132 (7%)

Query: 5   IHTLADHGDDVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSP 64
           +HTL  H + V    F    + + SLD +IR++ +     +       HT   H    S 
Sbjct: 454 LHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCI-------HTLTGHQSLTSG 506

Query: 65  ---SGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTV 121
                +IL S + D T  +W+ + GQ L  ++ P+     V     +   + + + DGTV
Sbjct: 507 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV 566

Query: 122 VLWNAQSYKLYR 133
            LW+ ++ +  R
Sbjct: 567 KLWDLKTGEFIR 578


>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 70/213 (32%), Positives = 98/213 (46%), Gaps = 16/213 (7%)

Query: 8   LADHGDDVNCCAFS--FSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPS 65
           L  H   V   +FS   + L + S D T+RL+SL+ FT L     K H Y V    FSP 
Sbjct: 539 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVG--YKGHNYPVWDTQFSPY 596

Query: 66  GHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWN 125
           G+   S   D    LW T++ Q L +        V   +F P+S  +A+G+AD TV LW+
Sbjct: 597 GYYFVSGGHDRVARLWATDHYQPLRIFAGHLAD-VNCTRFHPNSNYVATGSADRTVRLWD 655

Query: 126 AQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCLHSE-KAHDLGIT 184
             +    R  +   G + +  FSPNG F  TG++ G + +WD     +  E K H   + 
Sbjct: 656 VLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVC 715

Query: 185 CCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIW 217
              FS     DGE       LAS   D  V++W
Sbjct: 716 SLRFS----RDGE------ILASGSMDNTVRLW 738



 Score = 79.0 bits (193), Expect = 9e-15
 Identities = 69/248 (27%), Positives = 110/248 (44%), Gaps = 24/248 (9%)

Query: 73  STDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKLY 132
           S D    + + +    L ++   SG PV    FSPD   L S + DGTV LW+ Q++   
Sbjct: 520 SDDVLERIMDEKTASELKILYGHSG-PVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCL 578

Query: 133 RCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVW-DDKMRCLHSEKAHDLGITCCDFSSQ 191
                 +  +    FSP G +FV+G       +W  D  + L     H   + C  F   
Sbjct: 579 VGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRF--H 636

Query: 192 PVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDG 251
           P S+         +A+   D  V++W V   + +          +GH  P+ +  FS +G
Sbjct: 637 PNSN--------YVATGSADRTVRLWDVLNGNCVRI-------FTGHKGPIHSLTFSPNG 681

Query: 252 QMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQF- 310
           + L +G+ D  V+++D     ++  L  HT  V +  F+ +  +LA+GSMD TV +W   
Sbjct: 682 RFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAI 741

Query: 311 ----DLET 314
               DLET
Sbjct: 742 KAFEDLET 749



 Score = 34.7 bits (78), Expect = 0.19
 Identities = 37/120 (30%), Positives = 46/120 (38%), Gaps = 42/120 (35%)

Query: 5   IHTLADHGDDVNCCAF--SFSLLATCSLDKTIRLYSL------RDFT-------ELPHSP 49
           +   A H  DVNC  F  + + +AT S D+T+RL+ +      R FT        L  SP
Sbjct: 620 LRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSP 679

Query: 50  ---------------------------LKFHTYAVHCCCFSPSGHILASCSTDGTTVLWN 82
                                      LK HT  V    FS  G ILAS S D T  LW+
Sbjct: 680 NGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739


>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
           sapiens]
          Length = 514

 Score = 79.7 bits (195), Expect = 5e-15
 Identities = 77/298 (25%), Positives = 120/298 (40%), Gaps = 43/298 (14%)

Query: 50  LKFHTYAVHCCCFSPSGHILASCSTDGTTVLWN-----TENGQMLAV--------MEQPS 96
           L+ H   V  C ++P   +LAS S D T  +WN     T     L +         + PS
Sbjct: 165 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPS 224

Query: 97  GSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVT 156
              V    ++ + T LA+G+ DG   +W          G  K G + A  ++  G+F ++
Sbjct: 225 NKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHK-GPIFALKWNKKGNFILS 283

Query: 157 GSSCGDLTVWDDKMRCLHSEKAHDLGITCCDFSSQPVSDGE-QGLQFFRLASCGQDCQVK 215
                   +WD      H+ +A         F S P  D + Q    F  ASC  D  + 
Sbjct: 284 AGVDKTTIIWD-----AHTGEAKQQ----FPFHSAPALDVDWQSNNTF--ASCSTDMCIH 332

Query: 216 IWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILH 275
           +        LG +   K T  GH   V A  +   G +L S S D ++ ++    +N +H
Sbjct: 333 VCK------LGQDRPIK-TFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVH 385

Query: 276 TLTQHTRYVTTCAFAPN---------TLLLATGSMDKTVNIWQFDLETLCQARRTEHQ 324
            L  H + + T  ++P           L+LA+ S D TV +W  D   +C    T+HQ
Sbjct: 386 DLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVD-RGICIHTLTKHQ 442



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 65/256 (25%), Positives = 107/256 (41%), Gaps = 16/256 (6%)

Query: 23  SLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVLWN 82
           +LLAT S D   R+++         S L  H   +    ++  G+ + S   D TT++W+
Sbjct: 238 TLLATGSYDGFARIWTKDGNLA---STLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWD 294

Query: 83  TENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSL 142
              G+  A  + P  S   +      +   AS + D  + +      +  +        +
Sbjct: 295 AHTGE--AKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEV 352

Query: 143 AACAFSPNGSFFVTGSSCGDLTVWDDKM-RCLHSEKAHDLGITCCDFSSQPVSDGEQGLQ 201
            A  + P G+   + S    L +W  K   C+H  +AH+  I    +S  P   G     
Sbjct: 353 NAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWS--PTGPGTNNPN 410

Query: 202 F-FRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVD 260
               LAS   D  V++W V     +        TL+ H  PV + AFS DG+ L SGS D
Sbjct: 411 ANLMLASASFDSTVRLWDVDRGICI-------HTLTKHQEPVYSVAFSPDGRYLASGSFD 463

Query: 261 KSVIVYDTNTENILHT 276
           K V +++T T  ++H+
Sbjct: 464 KCVHIWNTQTGALVHS 479



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 51/174 (29%), Positives = 81/174 (46%), Gaps = 15/174 (8%)

Query: 5   IHTLADHGDDVNCCAF--SFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCF 62
           I T   H ++VN   +  + +LLA+CS D T++++S++      H  L+ H   ++   +
Sbjct: 342 IKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQ-DNCVHD-LQAHNKEIYTIKW 399

Query: 63  SPSGH---------ILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLA 113
           SP+G          +LAS S D T  LW+ + G  +  + +    PV    FSPD   LA
Sbjct: 400 SPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQ-EPVYSVAFSPDGRYLA 458

Query: 114 SGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD 167
           SG+ D  V +WN Q+  L        G    C ++  G      +S G + V D
Sbjct: 459 SGSFDKCVHIWNTQTGALVHSYRGTGGIFEVC-WNAAGDKVGASASDGSVCVLD 511



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 41/162 (25%), Positives = 72/162 (44%), Gaps = 12/162 (7%)

Query: 21  SFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVL 80
           S +  A+CS D  I +  L    + P    + HT  V+   + P+G++LASCS D T  +
Sbjct: 318 SNNTFASCSTDMCIHVCKLGQ--DRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKI 375

Query: 81  WNTENGQMLAVMEQPSGSPVRVCQFSPD---------STCLASGAADGTVVLWNAQSYKL 131
           W+ +    +  + Q     +   ++SP          +  LAS + D TV LW+      
Sbjct: 376 WSMKQDNCVHDL-QAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGIC 434

Query: 132 YRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCL 173
               +     + + AFSP+G +  +GS    + +W+ +   L
Sbjct: 435 IHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGAL 476


>gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo
           sapiens]
          Length = 421

 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 68/225 (30%), Positives = 96/225 (42%), Gaps = 22/225 (9%)

Query: 53  HTYAVHCCCFSPSGH-ILASCSTDGTTVLWNT-ENGQMLAVMEQPSGSPVRVCQFSPDST 110
           HT  V    F+P G  IL S S D T  +W+  ++G M+ V+       V  C FSPDS+
Sbjct: 169 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNW-VYSCAFSPDSS 227

Query: 111 CLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM 170
            L S  A   V LWN   Y + R        + AC FSP+G+   T S    + +WD   
Sbjct: 228 MLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHN 287

Query: 171 RCLHSEKAHDLGITCCDFSS-------QPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTH 223
             +  E  H        F+        + VS    GL    +AS   D  V+ W +    
Sbjct: 288 GDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGL---HVASLADDKMVRFWRID--- 341

Query: 224 ILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDT 268
              + ++     +G C     CAFS DG +L +G+ D SV  + T
Sbjct: 342 -EDYPVQVAPLSNGLC-----CAFSTDGSVLAAGTHDGSVYFWAT 380



 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 51/177 (28%), Positives = 77/177 (43%), Gaps = 18/177 (10%)

Query: 4   LIHTLADHGDDVNCCAFS--FSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCC 61
           ++  L  H + V  CAFS   S+L +    K + L+++  +T +    L+ H + V  C 
Sbjct: 206 MMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMI--RKLEGHHHDVVACD 263

Query: 62  FSPSGHILASCSTDGTTVLWNTENGQMLAVMEQ--PSGSP----------VRVCQFSPDS 109
           FSP G +LA+ S D    +W+  NG +L       P  +P          VR   FS D 
Sbjct: 264 FSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDG 323

Query: 110 TCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVW 166
             +AS A D  V  W        +   + +G    CAFS +GS    G+  G +  W
Sbjct: 324 LHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSVYFW 378



 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 62/225 (27%), Positives = 95/225 (42%), Gaps = 35/225 (15%)

Query: 104 QFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFF-VTGSSCGD 162
           +F  D   LA+G  +G + +W+  + KL          +    F+P+GS   V+ S    
Sbjct: 135 RFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKT 194

Query: 163 LTVWD--DKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVS 220
           L VWD  D    +   + H   +  C FS  P S          L S G    V +W + 
Sbjct: 195 LRVWDLKDDGNMMKVLRGHQNWVYSCAFS--PDSS--------MLCSVGASKAVFLWNMD 244

Query: 221 -FTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENIL----H 275
            +T I          L GH   V+AC FS DG +L + S D  V ++D +  +IL    H
Sbjct: 245 KYTMI--------RKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGH 296

Query: 276 TLTQHT---------RYVTTCAFAPNTLLLATGSMDKTVNIWQFD 311
                T         R+V + +F+ + L +A+ + DK V  W+ D
Sbjct: 297 LFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRID 341



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 61/225 (27%), Positives = 92/225 (40%), Gaps = 26/225 (11%)

Query: 101 RVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSC 160
           R  +  P S CL +    GT  + N+ S +L R  S  DG        P          C
Sbjct: 56  RTVKLVPWSQCLQNFLLHGTKNVTNSSSLRLPRQNS--DGGQKN---KPREHII----DC 106

Query: 161 GDLTVWDDKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVS 220
           GD+ VW         EK       C +        G+  L    LA+   + ++KIW V 
Sbjct: 107 GDI-VWSLAFGSSVPEKQS----RCVNIEWHRFRFGQDQLL---LATGLNNGRIKIWDV- 157

Query: 221 FTHILGFELKYKSTLSGHCAPVLACAFSHDGQM-LVSGSVDKSVIVYDTNTE-NILHTLT 278
                 +  K    L  H   V    F+ DG + LVS S DK++ V+D   + N++  L 
Sbjct: 158 ------YTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLR 211

Query: 279 QHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFDLETLCQARRTEH 323
            H  +V +CAF+P++ +L +    K V +W  D  T+ +     H
Sbjct: 212 GHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHH 256


>gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo
           sapiens]
          Length = 275

 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 68/225 (30%), Positives = 96/225 (42%), Gaps = 22/225 (9%)

Query: 53  HTYAVHCCCFSPSGH-ILASCSTDGTTVLWNT-ENGQMLAVMEQPSGSPVRVCQFSPDST 110
           HT  V    F+P G  IL S S D T  +W+  ++G M+ V+       V  C FSPDS+
Sbjct: 23  HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNW-VYSCAFSPDSS 81

Query: 111 CLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM 170
            L S  A   V LWN   Y + R        + AC FSP+G+   T S    + +WD   
Sbjct: 82  MLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHN 141

Query: 171 RCLHSEKAHDLGITCCDFSS-------QPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTH 223
             +  E  H        F+        + VS    GL    +AS   D  V+ W +    
Sbjct: 142 GDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGL---HVASLADDKMVRFWRID--- 195

Query: 224 ILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDT 268
              + ++     +G C     CAFS DG +L +G+ D SV  + T
Sbjct: 196 -EDYPVQVAPLSNGLC-----CAFSTDGSVLAAGTHDGSVYFWAT 234



 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 51/177 (28%), Positives = 77/177 (43%), Gaps = 18/177 (10%)

Query: 4   LIHTLADHGDDVNCCAFS--FSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCC 61
           ++  L  H + V  CAFS   S+L +    K + L+++  +T +    L+ H + V  C 
Sbjct: 60  MMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMI--RKLEGHHHDVVACD 117

Query: 62  FSPSGHILASCSTDGTTVLWNTENGQMLAVMEQ--PSGSP----------VRVCQFSPDS 109
           FSP G +LA+ S D    +W+  NG +L       P  +P          VR   FS D 
Sbjct: 118 FSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDG 177

Query: 110 TCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVW 166
             +AS A D  V  W        +   + +G    CAFS +GS    G+  G +  W
Sbjct: 178 LHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSVYFW 232



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 34/104 (32%), Positives = 49/104 (47%), Gaps = 6/104 (5%)

Query: 205 LASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVI 264
           L S  +D  +++W       L  +      L GH   V +CAFS D  ML S    K+V 
Sbjct: 40  LVSASRDKTLRVWD------LKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVF 93

Query: 265 VYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
           +++ +   ++  L  H   V  C F+P+  LLAT S D  V IW
Sbjct: 94  LWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIW 137



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 53/182 (29%), Positives = 78/182 (42%), Gaps = 35/182 (19%)

Query: 147 FSPNGSFF-VTGSSCGDLTVWD--DKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFF 203
           F+P+GS   V+ S    L VWD  D    +   + H   +  C FS  P S         
Sbjct: 32  FAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFS--PDSS-------- 81

Query: 204 RLASCGQDCQVKIWIVS-FTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKS 262
            L S G    V +W +  +T I          L GH   V+AC FS DG +L + S D  
Sbjct: 82  MLCSVGASKAVFLWNMDKYTMI--------RKLEGHHHDVVACDFSPDGALLATASYDTR 133

Query: 263 VIVYDTNTENIL----HTLTQHT---------RYVTTCAFAPNTLLLATGSMDKTVNIWQ 309
           V ++D +  +IL    H     T         R+V + +F+ + L +A+ + DK V  W+
Sbjct: 134 VYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWR 193

Query: 310 FD 311
            D
Sbjct: 194 ID 195



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 29/91 (31%), Positives = 47/91 (51%), Gaps = 2/91 (2%)

Query: 235 LSGHCAPVLACAFSHDGQM-LVSGSVDKSVIVYDTNTE-NILHTLTQHTRYVTTCAFAPN 292
           L  H   V    F+ DG + LVS S DK++ V+D   + N++  L  H  +V +CAF+P+
Sbjct: 20  LVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPD 79

Query: 293 TLLLATGSMDKTVNIWQFDLETLCQARRTEH 323
           + +L +    K V +W  D  T+ +     H
Sbjct: 80  SSMLCSVGASKAVFLWNMDKYTMIRKLEGHH 110


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 49/159 (30%), Positives = 82/159 (51%), Gaps = 9/159 (5%)

Query: 3   KLIHTLADHGDDVNCCAFSF----SLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVH 58
           K++ TL  H    N C+  F      +A+ S D  I+L+ +R    +     + H+ AV 
Sbjct: 96  KILRTLMGH--KANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFR--YRGHSQAVR 151

Query: 59  CCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAAD 118
           C  FSP G  LAS + D T  LW+   G+M++     +G PV V +F P+   LASG++D
Sbjct: 152 CLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTG-PVNVVEFHPNEYLLASGSSD 210

Query: 119 GTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTG 157
            T+  W+ + +++  C   + G + +  F+P+G    +G
Sbjct: 211 RTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSG 249



 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 56/239 (23%), Positives = 102/239 (42%), Gaps = 19/239 (7%)

Query: 65  SGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLW 124
           SG +LA+   D    LW+      +  +   + SPV   + +     + +G+  G++ +W
Sbjct: 32  SGRLLATGGDDCRVNLWSINKPNCIMSLTGHT-SPVESVRLNTPEELIVAGSQSGSIRVW 90

Query: 125 NAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMR-CLHSEKAHDLGI 183
           + ++ K+ R       ++ +  F P G F  +GS   ++ +WD + + C+   + H   +
Sbjct: 91  DLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAV 150

Query: 184 TCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVL 243
            C  FS     DG+       LAS   D  VK+W ++         K  S   GH  PV 
Sbjct: 151 RCLRFS----PDGKW------LASAADDHTVKLWDLTAG-------KMMSEFPGHTGPVN 193

Query: 244 ACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMD 302
              F  +  +L SGS D+++  +D     ++  +      V +  F P+   L +G  D
Sbjct: 194 VVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD 252



 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 55/201 (27%), Positives = 82/201 (40%), Gaps = 18/201 (8%)

Query: 112 LASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD-DKM 170
           LA+G  D  V LW+          +     + +   +      V GS  G + VWD +  
Sbjct: 36  LATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAA 95

Query: 171 RCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELK 230
           + L +   H   I   DF       GE       +AS  QD  +K+W +      G   +
Sbjct: 96  KILRTLMGHKANICSLDFHPY----GEF------VASGSQDTNIKLWDIRRK---GCVFR 142

Query: 231 YKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFA 290
           Y+    GH   V    FS DG+ L S + D +V ++D     ++     HT  V    F 
Sbjct: 143 YR----GHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFH 198

Query: 291 PNTLLLATGSMDKTVNIWQFD 311
           PN  LLA+GS D+T+  W  +
Sbjct: 199 PNEYLLASGSSDRTIRFWDLE 219



 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 34/106 (32%), Positives = 45/106 (42%), Gaps = 1/106 (0%)

Query: 62  FSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTV 121
           F P G  +AS S D    LW+    +      +     VR  +FSPD   LAS A D TV
Sbjct: 113 FHPYGEFVASGSQDTNIKLWDIRR-KGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTV 171

Query: 122 VLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD 167
            LW+  + K+        G +    F PN     +GSS   +  WD
Sbjct: 172 KLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWD 217



 Score = 33.5 bits (75), Expect = 0.43
 Identities = 16/61 (26%), Positives = 29/61 (47%)

Query: 251 GQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQF 310
           G++L +G  D  V ++  N  N + +LT HT  V +        L+  GS   ++ +W  
Sbjct: 33  GRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDL 92

Query: 311 D 311
           +
Sbjct: 93  E 93


>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score = 75.9 bits (185), Expect = 8e-14
 Identities = 77/307 (25%), Positives = 124/307 (40%), Gaps = 46/307 (14%)

Query: 44  ELPHSP---LKFHTYAVHCCCFSPSGHILASCSTDGTTVLWN----TENGQMLAVMEQ-- 94
           E+P S    L+ H   V  C ++P   +LAS S D T  +WN    +  G    V+    
Sbjct: 168 EIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCI 227

Query: 95  -------PSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAF 147
                  PS   V    ++ + T LA+G+ DG   +W          G  K G + A  +
Sbjct: 228 REGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHK-GPIFALKW 286

Query: 148 SPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHDLGITCCDFSSQPVSDGE-QGLQFFRLA 206
           +  G++ ++        +WD      H+ +A         F S P  D + Q    F  A
Sbjct: 287 NRKGNYILSAGVDKTTIIWD-----AHTGEAKQQ----FPFHSAPALDVDWQNNTTF--A 335

Query: 207 SCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVY 266
           SC  D  + +        LG +   K T  GH   V A  +   G +L S S D ++ ++
Sbjct: 336 SCSTDMCIHVCR------LGCDRPVK-TFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 388

Query: 267 DTNTENILHTLTQHTRYVTTCAFAP---------NTLLLATGSMDKTVNIWQFDLETLCQ 317
               E  +H L  H + + T  ++P         + ++LA+ S D TV +W  +   +C 
Sbjct: 389 SMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIE-RGVCT 447

Query: 318 ARRTEHQ 324
              T+HQ
Sbjct: 448 HTLTKHQ 454



 Score = 65.9 bits (159), Expect = 8e-11
 Identities = 53/174 (30%), Positives = 80/174 (45%), Gaps = 15/174 (8%)

Query: 5   IHTLADHGDDVNCCAFSFS--LLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCF 62
           + T   H ++VN   +  S  LLA+CS D T++++S++   E+    L+ H   ++   +
Sbjct: 354 VKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ--EVCIHDLQAHNKEIYTIKW 411

Query: 63  SPSGH---------ILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLA 113
           SP+G          +LAS S D T  LW+ E G     + +    PV    FSPD   LA
Sbjct: 412 SPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQ-EPVYSVAFSPDGKYLA 470

Query: 114 SGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD 167
           SG+ D  V +WN QS  L        G    C ++  G      +S G + V D
Sbjct: 471 SGSFDKCVHIWNTQSGNLVHSYRGTGGIFEVC-WNARGDKVGASASDGSVCVLD 523



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 42/154 (27%), Positives = 69/154 (44%), Gaps = 18/154 (11%)

Query: 26  ATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVLWN--- 82
           A+CS D  I +  L    + P    + HT  V+   + PSG +LASCS D T  +W+   
Sbjct: 335 ASCSTDMCIHVCRLG--CDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ 392

Query: 83  --------TENGQMLAVMEQPSGSPVRVCQFSPDST-CLASGAADGTVVLWNAQSYKLYR 133
                     N ++  +   P+G        +P+S   LAS + D TV LW+ +      
Sbjct: 393 EVCIHDLQAHNKEIYTIKWSPTGPATS----NPNSNIMLASASFDSTVRLWDIERGVCTH 448

Query: 134 CGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD 167
             +     + + AFSP+G +  +GS    + +W+
Sbjct: 449 TLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWN 482


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.133    0.415 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,689,852
Number of Sequences: 37866
Number of extensions: 838297
Number of successful extensions: 5146
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 223
Number of HSP's successfully gapped in prelim test: 121
Number of HSP's that attempted gapping in prelim test: 2196
Number of HSP's gapped (non-prelim): 1639
length of query: 476
length of database: 18,247,518
effective HSP length: 106
effective length of query: 370
effective length of database: 14,233,722
effective search space: 5266477140
effective search space used: 5266477140
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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