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Search of human proteins with 189571683
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|189571683 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
(476 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|189571685 WD repeat, sterile alpha motif and U-box domain con... 981 0.0
gi|189571683 WD repeat, sterile alpha motif and U-box domain con... 981 0.0
gi|189571681 WD repeat, sterile alpha motif and U-box domain con... 981 0.0
gi|113865883 WD repeat domain 38 [Homo sapiens] 119 5e-27
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 104 2e-22
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 104 2e-22
gi|32189425 WD repeat domain 69 [Homo sapiens] 103 4e-22
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 98 2e-20
gi|26665869 WD repeat domain 51B [Homo sapiens] 97 4e-20
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 93 6e-19
gi|13376840 WD repeat domain 61 [Homo sapiens] 93 6e-19
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 90 4e-18
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 90 4e-18
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa... 89 1e-17
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 88 1e-17
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H... 88 1e-17
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho... 88 1e-17
gi|16554629 WD repeat domain 5 [Homo sapiens] 88 2e-17
gi|16554627 WD repeat domain 5 [Homo sapiens] 88 2e-17
gi|21536371 telomerase-associated protein 1 [Homo sapiens] 87 4e-17
gi|23199987 WD repeat domain 5B [Homo sapiens] 87 4e-17
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 83 5e-16
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 83 5e-16
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 83 5e-16
gi|21071067 TBP-associated factor 5 [Homo sapiens] 82 1e-15
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 80 5e-15
gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo ... 79 1e-14
gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo ... 79 1e-14
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 78 2e-14
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 76 8e-14
>gi|189571685 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
Length = 476
Score = 981 bits (2537), Expect = 0.0
Identities = 476/476 (100%), Positives = 476/476 (100%)
Query: 1 MVKLIHTLADHGDDVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCC 60
MVKLIHTLADHGDDVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCC
Sbjct: 1 MVKLIHTLADHGDDVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCC 60
Query: 61 CFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGT 120
CFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGT
Sbjct: 61 CFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGT 120
Query: 121 VVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHD 180
VVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHD
Sbjct: 121 VVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHD 180
Query: 181 LGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCA 240
LGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCA
Sbjct: 181 LGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCA 240
Query: 241 PVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGS 300
PVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGS
Sbjct: 241 PVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGS 300
Query: 301 MDKTVNIWQFDLETLCQARRTEHQLKQFTEDWSEEDVSTWLCAQDLKDLVGIFKMNNIDG 360
MDKTVNIWQFDLETLCQARRTEHQLKQFTEDWSEEDVSTWLCAQDLKDLVGIFKMNNIDG
Sbjct: 301 MDKTVNIWQFDLETLCQARRTEHQLKQFTEDWSEEDVSTWLCAQDLKDLVGIFKMNNIDG 360
Query: 361 KELLNLTKESLADDLKIESLGLRSKVLRKIEELRTKVKSLSSGIPDEFICPITRELMKDP 420
KELLNLTKESLADDLKIESLGLRSKVLRKIEELRTKVKSLSSGIPDEFICPITRELMKDP
Sbjct: 361 KELLNLTKESLADDLKIESLGLRSKVLRKIEELRTKVKSLSSGIPDEFICPITRELMKDP 420
Query: 421 VIASDGYSYEKEAMENWISKKKRTSPMTNLVLPSAVLTPNRTLKMAINRWLETHQK 476
VIASDGYSYEKEAMENWISKKKRTSPMTNLVLPSAVLTPNRTLKMAINRWLETHQK
Sbjct: 421 VIASDGYSYEKEAMENWISKKKRTSPMTNLVLPSAVLTPNRTLKMAINRWLETHQK 476
>gi|189571683 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
Length = 476
Score = 981 bits (2537), Expect = 0.0
Identities = 476/476 (100%), Positives = 476/476 (100%)
Query: 1 MVKLIHTLADHGDDVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCC 60
MVKLIHTLADHGDDVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCC
Sbjct: 1 MVKLIHTLADHGDDVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCC 60
Query: 61 CFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGT 120
CFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGT
Sbjct: 61 CFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGT 120
Query: 121 VVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHD 180
VVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHD
Sbjct: 121 VVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHD 180
Query: 181 LGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCA 240
LGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCA
Sbjct: 181 LGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCA 240
Query: 241 PVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGS 300
PVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGS
Sbjct: 241 PVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGS 300
Query: 301 MDKTVNIWQFDLETLCQARRTEHQLKQFTEDWSEEDVSTWLCAQDLKDLVGIFKMNNIDG 360
MDKTVNIWQFDLETLCQARRTEHQLKQFTEDWSEEDVSTWLCAQDLKDLVGIFKMNNIDG
Sbjct: 301 MDKTVNIWQFDLETLCQARRTEHQLKQFTEDWSEEDVSTWLCAQDLKDLVGIFKMNNIDG 360
Query: 361 KELLNLTKESLADDLKIESLGLRSKVLRKIEELRTKVKSLSSGIPDEFICPITRELMKDP 420
KELLNLTKESLADDLKIESLGLRSKVLRKIEELRTKVKSLSSGIPDEFICPITRELMKDP
Sbjct: 361 KELLNLTKESLADDLKIESLGLRSKVLRKIEELRTKVKSLSSGIPDEFICPITRELMKDP 420
Query: 421 VIASDGYSYEKEAMENWISKKKRTSPMTNLVLPSAVLTPNRTLKMAINRWLETHQK 476
VIASDGYSYEKEAMENWISKKKRTSPMTNLVLPSAVLTPNRTLKMAINRWLETHQK
Sbjct: 421 VIASDGYSYEKEAMENWISKKKRTSPMTNLVLPSAVLTPNRTLKMAINRWLETHQK 476
>gi|189571681 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
Length = 476
Score = 981 bits (2537), Expect = 0.0
Identities = 476/476 (100%), Positives = 476/476 (100%)
Query: 1 MVKLIHTLADHGDDVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCC 60
MVKLIHTLADHGDDVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCC
Sbjct: 1 MVKLIHTLADHGDDVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCC 60
Query: 61 CFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGT 120
CFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGT
Sbjct: 61 CFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGT 120
Query: 121 VVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHD 180
VVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHD
Sbjct: 121 VVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHD 180
Query: 181 LGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCA 240
LGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCA
Sbjct: 181 LGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCA 240
Query: 241 PVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGS 300
PVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGS
Sbjct: 241 PVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGS 300
Query: 301 MDKTVNIWQFDLETLCQARRTEHQLKQFTEDWSEEDVSTWLCAQDLKDLVGIFKMNNIDG 360
MDKTVNIWQFDLETLCQARRTEHQLKQFTEDWSEEDVSTWLCAQDLKDLVGIFKMNNIDG
Sbjct: 301 MDKTVNIWQFDLETLCQARRTEHQLKQFTEDWSEEDVSTWLCAQDLKDLVGIFKMNNIDG 360
Query: 361 KELLNLTKESLADDLKIESLGLRSKVLRKIEELRTKVKSLSSGIPDEFICPITRELMKDP 420
KELLNLTKESLADDLKIESLGLRSKVLRKIEELRTKVKSLSSGIPDEFICPITRELMKDP
Sbjct: 361 KELLNLTKESLADDLKIESLGLRSKVLRKIEELRTKVKSLSSGIPDEFICPITRELMKDP 420
Query: 421 VIASDGYSYEKEAMENWISKKKRTSPMTNLVLPSAVLTPNRTLKMAINRWLETHQK 476
VIASDGYSYEKEAMENWISKKKRTSPMTNLVLPSAVLTPNRTLKMAINRWLETHQK
Sbjct: 421 VIASDGYSYEKEAMENWISKKKRTSPMTNLVLPSAVLTPNRTLKMAINRWLETHQK 476
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 119 bits (299), Expect = 5e-27
Identities = 100/309 (32%), Positives = 138/309 (44%), Gaps = 27/309 (8%)
Query: 2 VKLIHTLADHGDDVNCCAFS--FSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHC 59
V+ + HG +VN AFS +L T S D + + R L L HT V
Sbjct: 11 VRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWR--LGGHTGPVKF 68
Query: 60 CCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADG 119
C FSP GH+ AS S D T LW+ + L V++ S V FSPDS LASG D
Sbjct: 69 CRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRS-VETVSFSPDSRQLASGGWDK 127
Query: 120 TVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM---RCLHSE 176
V+LW+ QS ++ R S+ + FSP + TGS + +WD +M H
Sbjct: 128 RVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQA 187
Query: 177 -KAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTL 235
+ H I+C +S+ + LAS D + IW + + +L L
Sbjct: 188 LEGHSANISCLCYSASGL-----------LASGSWDKTIHIWKPTTSSLL-------IQL 229
Query: 236 SGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLL 295
GH V + AFS D L S + V V+D NT L TL TCAF P+ +
Sbjct: 230 KGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKI 289
Query: 296 LATGSMDKT 304
L +G+ D+T
Sbjct: 290 LVSGAADQT 298
Score = 101 bits (251), Expect = 2e-21
Identities = 80/268 (29%), Positives = 118/268 (44%), Gaps = 21/268 (7%)
Query: 53 HTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCL 112
H V+ FSP G +L + S DG W T +GQ+L + +G PV+ C+FSPD
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTG-PVKFCRFSPDGHLF 78
Query: 113 ASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM-R 171
AS + D TV LW+ K R S+ +FSP+ +G + +WD + +
Sbjct: 79 ASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQ 138
Query: 172 CLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKY 231
L H I DFS LA+ D V IW +
Sbjct: 139 MLRLLVGHRDSIQSSDFSPTVNC----------LATGSWDSTVHIWDLRMVT----PAVS 184
Query: 232 KSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAP 291
L GH A + +S G +L SGS DK++ ++ T ++L L H +V + AF+P
Sbjct: 185 HQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSP 243
Query: 292 NTLLLATGSMDKTVNIWQFD----LETL 315
+ L LA+ + V +W + LETL
Sbjct: 244 DELWLASAGYSRMVKVWDCNTGKCLETL 271
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 104 bits (259), Expect = 2e-22
Identities = 87/308 (28%), Positives = 133/308 (43%), Gaps = 27/308 (8%)
Query: 11 HGDDVNCCAFSFSL--LATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHI 68
H D V C FS + LA+ S+D + ++ ++ + H AV C FSPSGH+
Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYR--FTGHKDAVTCVNFSPSGHL 75
Query: 69 LASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQS 128
LAS S D T +W N + + + + + VR F D + + D TV +W
Sbjct: 76 LASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134
Query: 129 YKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMR-CLHSEKAHDLGITCCD 187
K S + FSP+G V+ S + +WD R C+HS H +T D
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194
Query: 188 FSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILG-FELKYKSTLSGHCAPVLACA 246
F +A+ G D VK+W V +L ++L H A V +
Sbjct: 195 FHPSGTC----------IAAAGMDNTVKVWDVRTHRLLQHYQL--------HSAAVNGLS 236
Query: 247 FSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVN 306
F G L++ S D ++ + D +L+TL H TT AF+ A+G D+ V
Sbjct: 237 FHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVM 296
Query: 307 IWQ--FDL 312
+W+ FD+
Sbjct: 297 VWKSNFDI 304
Score = 82.4 bits (202), Expect = 8e-16
Identities = 62/220 (28%), Positives = 102/220 (46%), Gaps = 20/220 (9%)
Query: 100 VRVCQFSPDSTCLASGAADGTVVLWNAQSY-KLYRCGSVKDGSLAACAFSPNGSFFVTGS 158
V FS ++ LASG+ D +++W+ + + YR KD ++ FSP+G +GS
Sbjct: 22 VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKD-AVTCVNFSPSGHLLASGS 80
Query: 159 SCGDLTVWDDKMRCLHSE-KAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIW 217
+ +W ++ + +AH + F S DG+ + D VK+W
Sbjct: 81 RDKTVRIWVPNVKGESTVFRAHTATVRSVHFCS----DGQS------FVTASDDKTVKVW 130
Query: 218 IVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTL 277
TH K+ +LS H V FS DG+++VS S DK+V ++D ++ +H+
Sbjct: 131 A---TH----RQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSY 183
Query: 278 TQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFDLETLCQ 317
+H +VT F P+ +A MD TV +W L Q
Sbjct: 184 CEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQ 223
Score = 51.6 bits (122), Expect = 2e-06
Identities = 28/72 (38%), Positives = 40/72 (55%)
Query: 237 GHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLL 296
GH V FS + + L SGS+D ++V+ ++ + T H VT F+P+ LL
Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
Query: 297 ATGSMDKTVNIW 308
A+GS DKTV IW
Sbjct: 77 ASGSRDKTVRIW 88
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 104 bits (259), Expect = 2e-22
Identities = 87/308 (28%), Positives = 133/308 (43%), Gaps = 27/308 (8%)
Query: 11 HGDDVNCCAFSFSL--LATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHI 68
H D V C FS + LA+ S+D + ++ ++ + H AV C FSPSGH+
Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYR--FTGHKDAVTCVNFSPSGHL 75
Query: 69 LASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQS 128
LAS S D T +W N + + + + + VR F D + + D TV +W
Sbjct: 76 LASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134
Query: 129 YKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMR-CLHSEKAHDLGITCCD 187
K S + FSP+G V+ S + +WD R C+HS H +T D
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194
Query: 188 FSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILG-FELKYKSTLSGHCAPVLACA 246
F +A+ G D VK+W V +L ++L H A V +
Sbjct: 195 FHPSGTC----------IAAAGMDNTVKVWDVRTHRLLQHYQL--------HSAAVNGLS 236
Query: 247 FSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVN 306
F G L++ S D ++ + D +L+TL H TT AF+ A+G D+ V
Sbjct: 237 FHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVM 296
Query: 307 IWQ--FDL 312
+W+ FD+
Sbjct: 297 VWKSNFDI 304
Score = 82.4 bits (202), Expect = 8e-16
Identities = 62/220 (28%), Positives = 102/220 (46%), Gaps = 20/220 (9%)
Query: 100 VRVCQFSPDSTCLASGAADGTVVLWNAQSY-KLYRCGSVKDGSLAACAFSPNGSFFVTGS 158
V FS ++ LASG+ D +++W+ + + YR KD ++ FSP+G +GS
Sbjct: 22 VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKD-AVTCVNFSPSGHLLASGS 80
Query: 159 SCGDLTVWDDKMRCLHSE-KAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIW 217
+ +W ++ + +AH + F S DG+ + D VK+W
Sbjct: 81 RDKTVRIWVPNVKGESTVFRAHTATVRSVHFCS----DGQS------FVTASDDKTVKVW 130
Query: 218 IVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTL 277
TH K+ +LS H V FS DG+++VS S DK+V ++D ++ +H+
Sbjct: 131 A---TH----RQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSY 183
Query: 278 TQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFDLETLCQ 317
+H +VT F P+ +A MD TV +W L Q
Sbjct: 184 CEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQ 223
Score = 51.6 bits (122), Expect = 2e-06
Identities = 28/72 (38%), Positives = 40/72 (55%)
Query: 237 GHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLL 296
GH V FS + + L SGS+D ++V+ ++ + T H VT F+P+ LL
Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
Query: 297 ATGSMDKTVNIW 308
A+GS DKTV IW
Sbjct: 77 ASGSRDKTVRIW 88
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 103 bits (256), Expect = 4e-22
Identities = 79/311 (25%), Positives = 144/311 (46%), Gaps = 28/311 (9%)
Query: 5 IHTLADHGDDVNCCAFSFSL---LATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCC 61
++TL H + V AF+ +AT S DKT +L+S+ T + + HT + C
Sbjct: 127 LNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVE--TGKCYHTFRGHTAEIVCLS 184
Query: 62 FSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTV 121
F+P ++A+ S D T LW+ +NG+ + + S + + F+ + +G+ D TV
Sbjct: 185 FNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISL-SFNTSGDRIITGSFDHTV 243
Query: 122 VLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD-DKMRCLHSEKAHD 180
V+W+A + + +++ +F+ + S +TGS +WD +C+ + HD
Sbjct: 244 VVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHD 303
Query: 181 LGI--TCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGH 238
I +C D++ + + A+ D +I+ + + + L GH
Sbjct: 304 DEILDSCFDYTGKLI------------ATASADGTARIFSAATRKCI-------AKLEGH 344
Query: 239 CAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLAT 298
+ +F+ G L++GS DK+ ++D T L L HT + +CAF ++ T
Sbjct: 345 EGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVIT 404
Query: 299 GSMDKTVNIWQ 309
GS D T IW+
Sbjct: 405 GSKDNTCRIWR 415
Score = 82.0 bits (201), Expect = 1e-15
Identities = 57/212 (26%), Positives = 96/212 (45%), Gaps = 19/212 (8%)
Query: 99 PVRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFS-PNGSFFVTG 157
P+ + +C +G+ D T LW+ S + + A AF+ P G TG
Sbjct: 94 PLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATG 153
Query: 158 SSCGDLTVWD-DKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKI 216
S +W + +C H+ + H I C F+ Q +A+ D K+
Sbjct: 154 SFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTL----------VATGSMDTTAKL 203
Query: 217 WIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHT 276
W I E Y TL GH A +++ +F+ G +++GS D +V+V+D +T ++
Sbjct: 204 W-----DIQNGEEVY--TLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNI 256
Query: 277 LTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
L H +++ +F + L+ TGSMDKT +W
Sbjct: 257 LIGHCAEISSASFNWDCSLILTGSMDKTCKLW 288
Score = 80.5 bits (197), Expect = 3e-15
Identities = 62/260 (23%), Positives = 110/260 (42%), Gaps = 18/260 (6%)
Query: 50 LKFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDS 109
LK H + + SG + S D T LW+T +G+ L +E + +P
Sbjct: 88 LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYG 147
Query: 110 TCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD-D 168
+A+G+ D T LW+ ++ K Y + +F+P + TGS +WD
Sbjct: 148 DKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQ 207
Query: 169 KMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFE 228
+++ + H I F+ + G+ R+ + D V +W
Sbjct: 208 NGEEVYTLRGHSAEIISLSFN----TSGD------RIITGSFDHTVVVWDADTG------ 251
Query: 229 LKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCA 288
+ + L GHCA + + +F+ D ++++GS+DK+ ++D + TLT H +
Sbjct: 252 -RKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSC 310
Query: 289 FAPNTLLLATGSMDKTVNIW 308
F L+AT S D T I+
Sbjct: 311 FDYTGKLIATASADGTARIF 330
Score = 53.9 bits (128), Expect = 3e-07
Identities = 42/171 (24%), Positives = 76/171 (44%), Gaps = 17/171 (9%)
Query: 142 LAACAFSPNGSFFVTGSSCGDLTVWDDKM-RCLHSEKAHDLGITCCDFSSQPVSDGEQGL 200
L A + +GS F+TGS +WD L++ + H + F++ P D
Sbjct: 95 LTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNN-PYGD----- 148
Query: 201 QFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVD 260
++A+ D K+W V K T GH A ++ +F+ ++ +GS+D
Sbjct: 149 ---KIATGSFDKTCKLWSVETG-------KCYHTFRGHTAEIVCLSFNPQSTLVATGSMD 198
Query: 261 KSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFD 311
+ ++D ++TL H+ + + +F + + TGS D TV +W D
Sbjct: 199 TTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDAD 249
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 97.8 bits (242), Expect = 2e-20
Identities = 77/264 (29%), Positives = 114/264 (43%), Gaps = 23/264 (8%)
Query: 53 HTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCL 112
H AV C FSPSGH+LAS S D T +W N + + + + + VR F D
Sbjct: 22 HKDAVTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSF 80
Query: 113 ASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMR- 171
+ + D TV +W K S + FSP+G V+ S + +WD R
Sbjct: 81 VTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE 140
Query: 172 CLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILG-FELK 230
C+HS H +T DF +A+ G D VK+W V +L ++L
Sbjct: 141 CVHSYCEHGGFVTYVDFHPSGTC----------IAAAGMDNTVKVWDVRTHRLLQHYQL- 189
Query: 231 YKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFA 290
H A V +F G L++ S D ++ + D +L+TL H TT AF+
Sbjct: 190 -------HSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFS 242
Query: 291 PNTLLLATGSMDKTVNIWQ--FDL 312
A+G D+ V +W+ FD+
Sbjct: 243 RTGEYFASGGSDEQVMVWKSNFDI 266
Score = 82.8 bits (203), Expect = 6e-16
Identities = 81/294 (27%), Positives = 118/294 (40%), Gaps = 29/294 (9%)
Query: 11 HGDDVNCCAFSFS--LLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHI 68
H D V C FS S LLA+ S DKT+R++ E + + HT V F G
Sbjct: 22 HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGE--STVFRAHTATVRSVHFCSDGQS 79
Query: 69 LASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQS 128
+ S D T +W T + L + Q VR +FSPD + S + D TV LW+ S
Sbjct: 80 FVTASDDKTVKVWATHRQKFLFSLSQHINW-VRCAKFSPDGRLIVSASDDKTVKLWDKSS 138
Query: 129 YKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM-RCLHSEKAHDLGITCCD 187
+ G + F P+G+ + VWD + R L + H +
Sbjct: 139 RECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLS 198
Query: 188 FSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAF 247
F P + L + D +KI ++ L Y TL GH P AF
Sbjct: 199 F--HPSGN--------YLITASSDSTLKI-----LDLMEGRLLY--TLHGHQGPATTVAF 241
Query: 248 SHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSM 301
S G+ SG D+ V+V+ +N + + H VT P TL + G++
Sbjct: 242 SRTGEYFASGGSDEQVMVWKSNFDIVDH------GEVTKVPRPPATLASSMGNL 289
Score = 73.2 bits (178), Expect = 5e-13
Identities = 55/202 (27%), Positives = 92/202 (45%), Gaps = 20/202 (9%)
Query: 118 DGTVVLWNAQSY-KLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCLHSE 176
D +++W+ + + YR KD ++ FSP+G +GS + +W ++ +
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKD-AVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV 60
Query: 177 -KAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTL 235
+AH + F S DG+ + D VK+W TH K+ +L
Sbjct: 61 FRAHTATVRSVHFCS----DGQS------FVTASDDKTVKVWA---TH----RQKFLFSL 103
Query: 236 SGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLL 295
S H V FS DG+++VS S DK+V ++D ++ +H+ +H +VT F P+
Sbjct: 104 SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTC 163
Query: 296 LATGSMDKTVNIWQFDLETLCQ 317
+A MD TV +W L Q
Sbjct: 164 IAAAGMDNTVKVWDVRTHRLLQ 185
Score = 38.9 bits (89), Expect = 0.010
Identities = 19/50 (38%), Positives = 29/50 (58%)
Query: 259 VDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
+D ++V+ ++ + T H VT F+P+ LLA+GS DKTV IW
Sbjct: 1 MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW 50
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 96.7 bits (239), Expect = 4e-20
Identities = 64/201 (31%), Positives = 102/201 (50%), Gaps = 14/201 (6%)
Query: 25 LATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTE 84
LAT S DK+I+++S+ + + L HT+ V C FSP G ++ SCS D T +W+T
Sbjct: 117 LATASEDKSIKVWSM--YRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTT 174
Query: 85 NGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAA 144
N Q + G F+P TC+AS +D TV +W+ + KL + V G +
Sbjct: 175 NKQCVNNFSDSVGF-ANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNC 233
Query: 145 CAFSPNGSFFVTGSSCGDLTVWD-DKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFF 203
+F P+G++ +T SS G L + D + R +++ + H + FS +G + F
Sbjct: 234 ISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFS--------KGGELF 285
Query: 204 RLASCGQDCQVKIWIVSFTHI 224
AS G D QV +W +F +
Sbjct: 286 --ASGGADTQVLLWRTNFDEL 304
Score = 88.2 bits (217), Expect = 1e-17
Identities = 84/316 (26%), Positives = 132/316 (41%), Gaps = 37/316 (11%)
Query: 25 LATCSLDKTIRLYSLRDFTELPHSPLKF---HTYAVHCCCFSPSGHILASCSTDGTTVLW 81
LAT S D + L++ + PH+ H V FSP G++LAS S D T LW
Sbjct: 33 LATASWDTFLMLWNFK-----PHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLW 87
Query: 82 NTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQS----YKLYRCGSV 137
+ + + + +PVR FS D LA+ + D ++ +W+ Y LYR
Sbjct: 88 IPDKRGKFSEFKAHT-APVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYR---- 142
Query: 138 KDGSLAACA-FSPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHDLGIT-CCDFSSQPVSD 195
CA FSP+G V+ S + +WD + + + +G DF+
Sbjct: 143 -HTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTC- 200
Query: 196 GEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLV 255
+AS G D VK+W V +L H V +F G L+
Sbjct: 201 ---------IASAGSDQTVKVWDVRVNKLL-------QHYQVHSGGVNCISFHPSGNYLI 244
Query: 256 SGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFDLETL 315
+ S D ++ + D +++TL HT V T +F+ L A+G D V +W+ + + L
Sbjct: 245 TASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDEL 304
Query: 316 CQARRTEHQLKQFTED 331
T+ LK+ D
Sbjct: 305 HCKGLTKRNLKRLHFD 320
Score = 79.3 bits (194), Expect = 7e-15
Identities = 59/214 (27%), Positives = 103/214 (48%), Gaps = 20/214 (9%)
Query: 106 SPDSTCLASGAADGTVVLWNAQSY-KLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLT 164
SP+ LA+ + D ++LWN + + + YR KD + + FSP+G+ + S +
Sbjct: 27 SPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKD-VVTSVQFSPHGNLLASASRDRTVR 85
Query: 165 VWDDKMRCLHSE-KAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTH 223
+W R SE KAH + DFS+ DG QF LA+ +D +K+W +
Sbjct: 86 LWIPDKRGKFSEFKAHTAPVRSVDFSA----DG----QF--LATASEDKSIKVWSM---- 131
Query: 224 ILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRY 283
+ ++ +L H V FS DG+++VS S DK++ ++DT + ++ + +
Sbjct: 132 ---YRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGF 188
Query: 284 VTTCAFAPNTLLLATGSMDKTVNIWQFDLETLCQ 317
F P+ +A+ D+TV +W + L Q
Sbjct: 189 ANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQ 222
Score = 68.2 bits (165), Expect = 2e-11
Identities = 50/169 (29%), Positives = 75/169 (44%), Gaps = 18/169 (10%)
Query: 141 SLAACAFSPNGSFFVTGSSCGDLTVWDDKMRC-LHSEKAHDLGITCCDFSSQPVSDGEQG 199
++ + SPNG T S L +W+ K + H +T FS
Sbjct: 20 AITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNL----- 74
Query: 200 LQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSV 259
LAS +D V++WI + S H APV + FS DGQ L + S
Sbjct: 75 -----LASASRDRTVRLWIPD-------KRGKFSEFKAHTAPVRSVDFSADGQFLATASE 122
Query: 260 DKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
DKS+ V+ + L++L +HT +V F+P+ L+ + S DKT+ IW
Sbjct: 123 DKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIW 171
Score = 41.6 bits (96), Expect = 0.002
Identities = 21/72 (29%), Positives = 38/72 (52%)
Query: 237 GHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLL 296
GH A + + S +G+ L + S D +++++ + H VT+ F+P+ LL
Sbjct: 16 GHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLL 75
Query: 297 ATGSMDKTVNIW 308
A+ S D+TV +W
Sbjct: 76 ASASRDRTVRLW 87
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 92.8 bits (229), Expect = 6e-19
Identities = 81/306 (26%), Positives = 140/306 (45%), Gaps = 22/306 (7%)
Query: 5 IHTLADHGDDVNCCAF--SFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCF 62
I L+ H +V CC F + S LA+ D+ I L+++ + ++ LK H+ AV +
Sbjct: 59 IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCD-NYATLKGHSGAVMELHY 117
Query: 63 SPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVC---QFSPDSTCLASGAADG 119
+ G +L S STD T +W++E G+ + ++ + S V C + P C +G+ DG
Sbjct: 118 NTDGSMLFSASTDKTVAVWDSETGERVKRLKGHT-SFVNSCYPARRGPQLVC--TGSDDG 174
Query: 120 TVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCL-HSEKA 178
TV LW+ + + + A F+ ++G D+ VWD + L ++ +
Sbjct: 175 TVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRG 233
Query: 179 HDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVS-FTHILGFELKYKSTLSG 237
H +T SS+ L S D V++W V F ++ +
Sbjct: 234 HADSVTGLSLSSEGSY----------LLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHN 283
Query: 238 HCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLA 297
+L C++S DG + +GS D+ V V+DT + IL+ L H + AF P+ ++
Sbjct: 284 FEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIII 343
Query: 298 TGSMDK 303
+ S DK
Sbjct: 344 SASSDK 349
Score = 65.5 bits (158), Expect = 1e-10
Identities = 52/212 (24%), Positives = 87/212 (41%), Gaps = 21/212 (9%)
Query: 100 VRVCQFSPDSTCLASGAADGTVVLWNAQS-YKLYRCGSVKDGSLAACAFSPNGSFFVTGS 158
V C+F P+ + LAS D ++LWN Y G++ ++ +GS + S
Sbjct: 69 VYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSAS 128
Query: 159 SCGDLTVWDDKM-RCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIW 217
+ + VWD + + K H + C P G Q + + D VK+W
Sbjct: 129 TDKTVAVWDSETGERVKRLKGHTSFVNSC----YPARRGPQ-----LVCTGSDDGTVKLW 179
Query: 218 -IVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHT 276
I I F+ Y+ VLA F+ ++SG +D + V+D + +T
Sbjct: 180 DIRKKAAIQTFQNTYQ---------VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYT 230
Query: 277 LTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
+ H VT + + L + +MD TV +W
Sbjct: 231 MRGHADSVTGLSLSSEGSYLLSNAMDNTVRVW 262
Score = 63.9 bits (154), Expect = 3e-10
Identities = 49/162 (30%), Positives = 75/162 (46%), Gaps = 18/162 (11%)
Query: 179 HDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGH 238
H+ + CC F + LAS G D + +W ++ G Y +TL GH
Sbjct: 65 HEGEVYCCKFHPNGST----------LASAGFDRLILLW-----NVYGDCDNY-ATLKGH 108
Query: 239 CAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPN-TLLLA 297
V+ ++ DG ML S S DK+V V+D+ T + L HT +V +C A L+
Sbjct: 109 SGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVC 168
Query: 298 TGSMDKTVNIWQFDLETLCQARRTEHQLKQFT-EDWSEEDVS 338
TGS D TV +W + Q + +Q+ T D S++ +S
Sbjct: 169 TGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIIS 210
>gi|13376840 WD repeat domain 61 [Homo sapiens]
Length = 305
Score = 92.8 bits (229), Expect = 6e-19
Identities = 82/287 (28%), Positives = 128/287 (44%), Gaps = 23/287 (8%)
Query: 25 LATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTE 84
+ T SLD ++++ RD L+ H V S + I AS S D LW+ E
Sbjct: 35 VVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLE 94
Query: 85 NGQMLAVMEQPSGSPVRV--CQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSL 142
NG+ + ++ PV FSPDS LA+G G V ++ +S K + +
Sbjct: 95 NGKQIKSID---AGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFI 151
Query: 143 AACAFSPNGSFFVTGSSCGDLTVWDDKM-RCLHSEKAHDLGITCCDFSSQPVSDGEQGLQ 201
+ A+SP+G + +G+ G + ++D + LH+ + H + I FS P S
Sbjct: 152 LSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFS--PDSQ------ 203
Query: 202 FFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDK 261
L + D +KI+ V ++ G TLSGH + VL AF D VS S DK
Sbjct: 204 --LLVTASDDGYIKIYDVQHANLAG-------TLSGHASWVLNVAFCPDDTHFVSSSSDK 254
Query: 262 SVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
SV V+D T +HT H V + N + + D+ ++I+
Sbjct: 255 SVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301
Score = 71.6 bits (174), Expect = 1e-12
Identities = 60/217 (27%), Positives = 98/217 (45%), Gaps = 27/217 (12%)
Query: 113 ASGAADGTVVLWNAQSYKLYRCGSVKDGSLAA--CAFSPNGSFFVTGSSCGDLTVWDDKM 170
AS + D + LW+ ++ K + S+ G + A AFSP+ + TG+ G + ++ +
Sbjct: 80 ASSSLDAHIRLWDLENGKQIK--SIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVES 137
Query: 171 RCLHSEKAHDL---GITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGF 227
+K + L G + P DG+ LAS D + I+ ++ +L
Sbjct: 138 ----GKKEYSLDTRGKFILSIAYSP--DGKY------LASGAIDGIINIFDIATGKLL-- 183
Query: 228 ELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTC 287
TL GH P+ + FS D Q+LV+ S D + +YD N+ TL+ H +V
Sbjct: 184 -----HTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNV 238
Query: 288 AFAPNTLLLATGSMDKTVNIWQFDLETLCQARRTEHQ 324
AF P+ + S DK+V +W T C +HQ
Sbjct: 239 AFCPDDTHFVSSSSDKSVKVWDVGTRT-CVHTFFDHQ 274
Score = 59.7 bits (143), Expect = 6e-09
Identities = 50/187 (26%), Positives = 83/187 (44%), Gaps = 28/187 (14%)
Query: 150 NGSFFVTGSSCGDLTVW---DDKMRCLHSEKAHDLGITCCDFS-SQPVSDGEQGLQFFRL 205
N VTGS + VW D+++ S + H LG+ D S + P++ RL
Sbjct: 31 NSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRL 90
Query: 206 ASCGQDCQVK--------IWIVSFT---------------HILGFEL-KYKSTLSGHCAP 241
Q+K W ++F+ +I G E K + +L
Sbjct: 91 WDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKF 150
Query: 242 VLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSM 301
+L+ A+S DG+ L SG++D + ++D T +LHTL H + + F+P++ LL T S
Sbjct: 151 ILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASD 210
Query: 302 DKTVNIW 308
D + I+
Sbjct: 211 DGYIKIY 217
Score = 30.8 bits (68), Expect = 2.8
Identities = 24/82 (29%), Positives = 34/82 (41%), Gaps = 4/82 (4%)
Query: 3 KLIHTLADHGDDVNCCAFS--FSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCC 60
KL+HTL H + FS LL T S D I++Y ++ L H V
Sbjct: 181 KLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLA--GTLSGHASWVLNV 238
Query: 61 CFSPSGHILASCSTDGTTVLWN 82
F P S S+D + +W+
Sbjct: 239 AFCPDDTHFVSSSSDKSVKVWD 260
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 90.1 bits (222), Expect = 4e-18
Identities = 90/354 (25%), Positives = 144/354 (40%), Gaps = 64/354 (18%)
Query: 3 KLIHTLADHGDDVNCCAFSFS----LLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVH 58
+L+HT +H + VNCC F+ S LLAT S D ++L+ L + + + HT +V+
Sbjct: 690 ELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQ--KECRNTMFGHTNSVN 747
Query: 59 CCCFSPSGHILASCSTDGTTVLWNTENG---------QMLAVMEQPSGSP---VRVCQFS 106
C FSP +LASCS DGT LW+ + Q +E P V+ C +S
Sbjct: 748 HCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWS 807
Query: 107 PDSTCLASGAADGTVVLWNAQS-YKLYRCGSVKDGSLA---ACAFSPNGSFFVTGSSCGD 162
D + AA + LWN S K+ C G L+ FSP+GS F+T S
Sbjct: 808 ADGARIMV-AAKNKIFLWNTDSRSKVADC----RGHLSWVHGVMFSPDGSSFLTSSDDQT 862
Query: 163 LTVWDDKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFT 222
+ +W+ K C +S Q V Q + ++ +++
Sbjct: 863 IRLWETKKVCKNS----------AVMLKQEVDVVFQ--------------ENEVMVLAVD 898
Query: 223 HILGFELKYKSTLSGHC--------APVLACAFSHDGQMLVSGSVDKSVIVYDTNTENIL 274
HI +L ++G A V C S Q + G + ++ + + I
Sbjct: 899 HIRRLQL-----INGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIF 953
Query: 275 HTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFDLETLCQARRTEHQLKQF 328
+ QH + V F + L + S D + +W + L+ R + +K F
Sbjct: 954 QSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDF 1007
Score = 89.4 bits (220), Expect = 7e-18
Identities = 69/279 (24%), Positives = 122/279 (43%), Gaps = 21/279 (7%)
Query: 40 RDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSP 99
++ T L ++ HT AV+ CFS G +ASC D T ++ E G+ L ++
Sbjct: 601 KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHE-DE 659
Query: 100 VRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAF--SPNGSFFVTG 157
V C FS D +A+ + D V +WN+ + +L + C F S + TG
Sbjct: 660 VLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATG 719
Query: 158 SSCGDLTVWD-DKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKI 216
SS L +WD ++ C ++ H + C FS LASC D +K+
Sbjct: 720 SSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDK----------LLASCSADGTLKL 769
Query: 217 WIVSFT------HILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNT 270
W + ++ F L + V C++S DG ++ + +K + +++T++
Sbjct: 770 WDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLWNTDS 828
Query: 271 ENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQ 309
+ + H +V F+P+ T S D+T+ +W+
Sbjct: 829 RSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 867
Score = 62.8 bits (151), Expect = 7e-10
Identities = 38/110 (34%), Positives = 60/110 (54%), Gaps = 9/110 (8%)
Query: 204 RLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSV 263
R+ASCG D ++++ L E+K H VL CAFS D + + + SVDK V
Sbjct: 629 RIASCGADKTLQVFKAETGEKL-LEIK------AHEDEVLCCAFSTDDRFIATCSVDKKV 681
Query: 264 IVYDTNTENILHTLTQHTRYVTTCAFAPNT--LLLATGSMDKTVNIWQFD 311
++++ T ++HT +H+ V C F ++ LLLATGS D + +W +
Sbjct: 682 KIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 731
Score = 58.2 bits (139), Expect = 2e-08
Identities = 67/297 (22%), Positives = 110/297 (37%), Gaps = 64/297 (21%)
Query: 53 HTYAVHCCCFSPSGHILASCSTDGTTVLWNT--------------------ENGQMLAVM 92
H VH FSP G + S D T LW T EN M+ +
Sbjct: 838 HLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAV 897
Query: 93 EQP----------------SGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGS 136
+ + + V C SP +A G +G + + + ++++
Sbjct: 898 DHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRF 957
Query: 137 VKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM-RCL----HSEKAHDLGITCCDFSSQ 191
++ F+ + ++ S ++ VW+ ++ +C+ H E D +
Sbjct: 958 QHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRL-------- 1009
Query: 192 PVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDG 251
L+ RL S D VK+W + I G + K H VL+C SHD
Sbjct: 1010 --------LKNSRLLSWSFDGTVKVWNI----ITGNKEK---DFVCHQGTVLSCDISHDA 1054
Query: 252 QMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
S S DK+ ++ + LH L H V AF+ ++ LLATG + + IW
Sbjct: 1055 TKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIW 1111
Score = 52.0 bits (123), Expect = 1e-06
Identities = 65/267 (24%), Positives = 105/267 (39%), Gaps = 42/267 (15%)
Query: 57 VHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGA 116
V CCC SP +A +G + N ++ Q + + QF+ D L S +
Sbjct: 921 VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHI-QFTADEKTLISSS 979
Query: 117 ADGTVVLWNAQSYK-LYRCG---SVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRC 172
D + +WN Q K ++ G +VKD L S ++ S G + VW+ +
Sbjct: 980 DDAEIQVWNWQLDKCIFLRGHQETVKDFRLL------KNSRLLSWSFDGTVKVWN--IIT 1031
Query: 173 LHSEK---AHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFEL 229
+ EK H + CD S + +S D KIW SF +L
Sbjct: 1032 GNKEKDFVCHQGTVLSCDISHDAT----------KFSSTSADKTAKIW--SFDLLLPLH- 1078
Query: 230 KYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHT--------LTQHT 281
L GH V AFS D +L +G + + +++ + +LH H
Sbjct: 1079 ----ELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHG 1134
Query: 282 RYVTTCAFAPN-TLLLATGSMDKTVNI 307
+VT F+P+ +L++ G K N+
Sbjct: 1135 GWVTDLCFSPDGKMLISAGGYIKWWNV 1161
Score = 48.5 bits (114), Expect = 1e-05
Identities = 45/159 (28%), Positives = 68/159 (42%), Gaps = 14/159 (8%)
Query: 14 DVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCS 73
D++ A FS + S DKT +++S LP L+ H V C FS +LA+
Sbjct: 1049 DISHDATKFS---STSADKTAKIWSFDLL--LPLHELRGHNGCVRCSAFSVDSTLLATGD 1103
Query: 74 TDGTTVLWNTENGQMLAVMEQPS-------GSPVRVCQFSPDSTCLASGAADGTVVLWNA 126
+G +WN NG++L + S G V FSPD L S A G + WN
Sbjct: 1104 DNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLIS--AGGYIKWWNV 1161
Query: 127 QSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTV 165
+ + + +L SP+ +VT + G L +
Sbjct: 1162 VTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYI 1200
Score = 38.1 bits (87), Expect = 0.018
Identities = 36/113 (31%), Positives = 51/113 (45%), Gaps = 13/113 (11%)
Query: 5 IHTLADHGDDVNCCAFSF--SLLATCSLDKTIRLYSLRDFTELPH--SPLKFHTYAVH-- 58
+H L H V C AFS +LLAT + IR++++ + EL H +PL A H
Sbjct: 1077 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN-GELLHLCAPLSEEGAATHGG 1135
Query: 59 ---CCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPD 108
CFSP G +L S G WN G+ +G+ ++ SPD
Sbjct: 1136 WVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTF-YTNGTNLKKIHVSPD 1185
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 90.1 bits (222), Expect = 4e-18
Identities = 90/354 (25%), Positives = 144/354 (40%), Gaps = 64/354 (18%)
Query: 3 KLIHTLADHGDDVNCCAFSFS----LLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVH 58
+L+HT +H + VNCC F+ S LLAT S D ++L+ L + + + HT +V+
Sbjct: 679 ELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQ--KECRNTMFGHTNSVN 736
Query: 59 CCCFSPSGHILASCSTDGTTVLWNTENG---------QMLAVMEQPSGSP---VRVCQFS 106
C FSP +LASCS DGT LW+ + Q +E P V+ C +S
Sbjct: 737 HCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWS 796
Query: 107 PDSTCLASGAADGTVVLWNAQS-YKLYRCGSVKDGSLA---ACAFSPNGSFFVTGSSCGD 162
D + AA + LWN S K+ C G L+ FSP+GS F+T S
Sbjct: 797 ADGARIMV-AAKNKIFLWNTDSRSKVADC----RGHLSWVHGVMFSPDGSSFLTSSDDQT 851
Query: 163 LTVWDDKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFT 222
+ +W+ K C +S Q V Q + ++ +++
Sbjct: 852 IRLWETKKVCKNS----------AVMLKQEVDVVFQ--------------ENEVMVLAVD 887
Query: 223 HILGFELKYKSTLSGHC--------APVLACAFSHDGQMLVSGSVDKSVIVYDTNTENIL 274
HI +L ++G A V C S Q + G + ++ + + I
Sbjct: 888 HIRRLQL-----INGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIF 942
Query: 275 HTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFDLETLCQARRTEHQLKQF 328
+ QH + V F + L + S D + +W + L+ R + +K F
Sbjct: 943 QSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDF 996
Score = 89.4 bits (220), Expect = 7e-18
Identities = 69/279 (24%), Positives = 122/279 (43%), Gaps = 21/279 (7%)
Query: 40 RDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSP 99
++ T L ++ HT AV+ CFS G +ASC D T ++ E G+ L ++
Sbjct: 590 KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHE-DE 648
Query: 100 VRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAF--SPNGSFFVTG 157
V C FS D +A+ + D V +WN+ + +L + C F S + TG
Sbjct: 649 VLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATG 708
Query: 158 SSCGDLTVWD-DKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKI 216
SS L +WD ++ C ++ H + C FS LASC D +K+
Sbjct: 709 SSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDK----------LLASCSADGTLKL 758
Query: 217 WIVSFT------HILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNT 270
W + ++ F L + V C++S DG ++ + +K + +++T++
Sbjct: 759 WDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLWNTDS 817
Query: 271 ENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQ 309
+ + H +V F+P+ T S D+T+ +W+
Sbjct: 818 RSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 856
Score = 62.8 bits (151), Expect = 7e-10
Identities = 38/110 (34%), Positives = 60/110 (54%), Gaps = 9/110 (8%)
Query: 204 RLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSV 263
R+ASCG D ++++ L E+K H VL CAFS D + + + SVDK V
Sbjct: 618 RIASCGADKTLQVFKAETGEKL-LEIK------AHEDEVLCCAFSTDDRFIATCSVDKKV 670
Query: 264 IVYDTNTENILHTLTQHTRYVTTCAFAPNT--LLLATGSMDKTVNIWQFD 311
++++ T ++HT +H+ V C F ++ LLLATGS D + +W +
Sbjct: 671 KIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 720
Score = 58.2 bits (139), Expect = 2e-08
Identities = 67/297 (22%), Positives = 110/297 (37%), Gaps = 64/297 (21%)
Query: 53 HTYAVHCCCFSPSGHILASCSTDGTTVLWNT--------------------ENGQMLAVM 92
H VH FSP G + S D T LW T EN M+ +
Sbjct: 827 HLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAV 886
Query: 93 EQP----------------SGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGS 136
+ + + V C SP +A G +G + + + ++++
Sbjct: 887 DHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRF 946
Query: 137 VKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM-RCL----HSEKAHDLGITCCDFSSQ 191
++ F+ + ++ S ++ VW+ ++ +C+ H E D +
Sbjct: 947 QHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRL-------- 998
Query: 192 PVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDG 251
L+ RL S D VK+W + I G + K H VL+C SHD
Sbjct: 999 --------LKNSRLLSWSFDGTVKVWNI----ITGNKEK---DFVCHQGTVLSCDISHDA 1043
Query: 252 QMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
S S DK+ ++ + LH L H V AF+ ++ LLATG + + IW
Sbjct: 1044 TKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIW 1100
Score = 52.0 bits (123), Expect = 1e-06
Identities = 65/267 (24%), Positives = 105/267 (39%), Gaps = 42/267 (15%)
Query: 57 VHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGA 116
V CCC SP +A +G + N ++ Q + + QF+ D L S +
Sbjct: 910 VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHI-QFTADEKTLISSS 968
Query: 117 ADGTVVLWNAQSYK-LYRCG---SVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRC 172
D + +WN Q K ++ G +VKD L S ++ S G + VW+ +
Sbjct: 969 DDAEIQVWNWQLDKCIFLRGHQETVKDFRLL------KNSRLLSWSFDGTVKVWN--IIT 1020
Query: 173 LHSEK---AHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFEL 229
+ EK H + CD S + +S D KIW SF +L
Sbjct: 1021 GNKEKDFVCHQGTVLSCDISHDAT----------KFSSTSADKTAKIW--SFDLLLPLH- 1067
Query: 230 KYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHT--------LTQHT 281
L GH V AFS D +L +G + + +++ + +LH H
Sbjct: 1068 ----ELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHG 1123
Query: 282 RYVTTCAFAPN-TLLLATGSMDKTVNI 307
+VT F+P+ +L++ G K N+
Sbjct: 1124 GWVTDLCFSPDGKMLISAGGYIKWWNV 1150
Score = 48.5 bits (114), Expect = 1e-05
Identities = 45/159 (28%), Positives = 68/159 (42%), Gaps = 14/159 (8%)
Query: 14 DVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCS 73
D++ A FS + S DKT +++S LP L+ H V C FS +LA+
Sbjct: 1038 DISHDATKFS---STSADKTAKIWSFDLL--LPLHELRGHNGCVRCSAFSVDSTLLATGD 1092
Query: 74 TDGTTVLWNTENGQMLAVMEQPS-------GSPVRVCQFSPDSTCLASGAADGTVVLWNA 126
+G +WN NG++L + S G V FSPD L S A G + WN
Sbjct: 1093 DNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLIS--AGGYIKWWNV 1150
Query: 127 QSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTV 165
+ + + +L SP+ +VT + G L +
Sbjct: 1151 VTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYI 1189
Score = 38.1 bits (87), Expect = 0.018
Identities = 36/113 (31%), Positives = 51/113 (45%), Gaps = 13/113 (11%)
Query: 5 IHTLADHGDDVNCCAFSF--SLLATCSLDKTIRLYSLRDFTELPH--SPLKFHTYAVH-- 58
+H L H V C AFS +LLAT + IR++++ + EL H +PL A H
Sbjct: 1066 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN-GELLHLCAPLSEEGAATHGG 1124
Query: 59 ---CCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPD 108
CFSP G +L S G WN G+ +G+ ++ SPD
Sbjct: 1125 WVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTF-YTNGTNLKKIHVSPD 1174
>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
sapiens]
Length = 472
Score = 88.6 bits (218), Expect = 1e-17
Identities = 78/276 (28%), Positives = 125/276 (45%), Gaps = 28/276 (10%)
Query: 43 TELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRV 102
+++P L H +AV C F L S S D T LW+ +G ++ E +PV
Sbjct: 91 SKIPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVE 150
Query: 103 CQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVK-DGSLAACAFSPNGSFFVTGSSCG 161
C + DS+ + + + D TV W+ ++ KL V+ D + +C FSP+G + V+G
Sbjct: 151 CSITGDSSRVIAASYDKTVRAWDLETGKL--LWKVRYDTFIVSCKFSPDGKYVVSGFDVD 208
Query: 162 -DLTVWDDKMRCLHS--EKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWI 218
+ + D + S + H IT C F P S R+AS D +KIW
Sbjct: 209 HGICIMDAENITTVSVIKDHHTRSITSCCF--DPDSQ--------RVASVSLDRCIKIWD 258
Query: 219 VSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILH--- 275
V+ L + H + C F+ G L + S DK++ +++ +T +
Sbjct: 259 VTSQATL------LTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGA 312
Query: 276 --TLTQ-HTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
TL Q H V++C FA ++ L +G D+TV IW
Sbjct: 313 CVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIW 348
Score = 82.0 bits (201), Expect = 1e-15
Identities = 78/318 (24%), Positives = 135/318 (42%), Gaps = 36/318 (11%)
Query: 8 LADHGDDVNCCAFSF--SLLATCSLDKTIRLYS------LRDFTELPHSPLKFHTYAVHC 59
L+ H V+ C F + L + S D T++L+ +RDF P +P+ V C
Sbjct: 98 LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPV------VEC 151
Query: 60 CCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGA-AD 118
S ++A+ S D T W+ E G++L + + + C+FSPD + SG D
Sbjct: 152 SITGDSSRVIAA-SYDKTVRAWDLETGKLLWKVRYDTF--IVSCKFSPDGKYVVSGFDVD 208
Query: 119 GTVVLWNAQSYKLYRCGSVKDG---SLAACAFSPNGSFFVTGSSCGDLTVWD--DKMRCL 173
+ + +A++ + +KD S+ +C F P+ + S + +WD + L
Sbjct: 209 HGICIMDAEN--ITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLL 266
Query: 174 HSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKS 233
KAH I+ C F+ L + D +KIW V +
Sbjct: 267 TITKAHSNAISNCCFT----------FSGHFLCTSSWDKNLKIWNVHTGEFRNCGACV-T 315
Query: 234 TLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNT 293
+ GH V +C F+ D L+SG D++V ++D +L H +V A + N
Sbjct: 316 LMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNK 375
Query: 294 LLLATGSMDKTVNIWQFD 311
+ + S D+T+ +W +
Sbjct: 376 KWILSASKDRTMRLWNIE 393
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 88.2 bits (217), Expect = 1e-17
Identities = 81/319 (25%), Positives = 138/319 (43%), Gaps = 27/319 (8%)
Query: 6 HTLADHGDDVNCCAFS--FSLLATCSLDKTIRL--YSLRDFTELPHSPLKFHTYAVHCCC 61
+ L+ H V F FS++ + S D TI++ Y DF LK HT +V
Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERT----LKGHTDSVQDIS 157
Query: 62 FSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTV 121
F SG +LASCS D T LW+ + + + M + V P+ + S + D T+
Sbjct: 158 FDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVA-IMPNGDHIVSASRDKTI 216
Query: 122 VLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMR-CLHSEKAHD 180
+W Q+ + + + + +G+ + S+ + VW + C + H+
Sbjct: 217 KMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHE 276
Query: 181 LGITCCD------FSSQPVSDGEQGLQFFR----LASCGQDCQVKIWIVSFTHILGFELK 230
+ C +SS + G + + + L S +D +K+W VS L
Sbjct: 277 HVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCL----- 331
Query: 231 YKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFA 290
TL GH V F G+ ++S + DK++ V+D + + TL H +VT+ F
Sbjct: 332 --MTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFH 389
Query: 291 PNTLLLATGSMDKTVNIWQ 309
+ TGS+D+TV +W+
Sbjct: 390 KTAPYVVTGSVDQTVKVWE 408
Score = 80.5 bits (197), Expect = 3e-15
Identities = 70/289 (24%), Positives = 119/289 (41%), Gaps = 39/289 (13%)
Query: 45 LPHSPLKF----HTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPV 100
+P P K+ H V F P ++ S S D T +W+ E G ++ + S V
Sbjct: 95 IPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDS-V 153
Query: 101 RVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSC 160
+ F LAS +AD T+ LW+ Q ++ R D ++++ A PNG V+ S
Sbjct: 154 QDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRD 213
Query: 161 GDLTVWDDKMR-CLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIV 219
+ +W+ + C+ + H + +P DG +ASC D V++W+V
Sbjct: 214 KTIKMWEVQTGYCVKTFTGHREWVRMV----RPNQDGTL------IASCSNDQTVRVWVV 263
Query: 220 SFTHILGFELKYKSTLSGHCAPVLACA------------------FSHDGQMLVSGSVDK 261
+ E K + H ++ A G L+SGS DK
Sbjct: 264 ATK-----ECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDK 318
Query: 262 SVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQF 310
++ ++D +T L TL H +V F + + + DKT+ +W +
Sbjct: 319 TIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDY 367
>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
sapiens]
Length = 1248
Score = 88.2 bits (217), Expect = 1e-17
Identities = 71/282 (25%), Positives = 118/282 (41%), Gaps = 22/282 (7%)
Query: 40 RDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSP 99
++ T L ++ HT AV+ CFS G +ASC D T ++ E G+ L ++
Sbjct: 601 KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHE-DE 659
Query: 100 VRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAF--SPNGSFFVTG 157
V C FS D +A+ + D V +WN+ + +L + C F S + TG
Sbjct: 660 VLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATG 719
Query: 158 SSCGDLTVWD-DKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKI 216
SS L +WD ++ C ++ H + C FS LASC D +K+
Sbjct: 720 SSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDK----------LLASCSADGTLKL 769
Query: 217 WIVSFT------HILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNT 270
W + ++ F L + V C++S DG ++ + +K + ++D +T
Sbjct: 770 WDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHT 828
Query: 271 ENILHTL-TQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFD 311
+L + T H + C F+P L V +W D
Sbjct: 829 SGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTD 870
Score = 85.5 bits (210), Expect = 1e-16
Identities = 75/321 (23%), Positives = 133/321 (41%), Gaps = 46/321 (14%)
Query: 11 HGDDVNCCAFSFS--LLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHI 68
H D V FS +A+C DKT++++ +L +K H V CC FS
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLE--IKAHEDEVLCCAFSTDDRF 671
Query: 69 LASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDS--TCLASGAADGTVVLWNA 126
+A+CS D +WN+ G+++ ++ S V C F+ S LA+G++D + LW+
Sbjct: 672 IATCSVDKKVKIWNSMTGELVHTYDEHS-EQVNCCHFTNSSHHLLLATGSSDCFLKLWDL 730
Query: 127 QSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDD-----------KMRCLHS 175
+ S+ C FSP+ + S+ G L +WD K L+
Sbjct: 731 NQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNL 790
Query: 176 EKAH---DLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYK 232
E ++ + CC +S +DG +I + + I F++
Sbjct: 791 EDPQEDMEVIVKCCSWS----ADG-----------------ARIMVAAKNKIFLFDIHTS 829
Query: 233 STL----SGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCA 288
L +GH + + C FS + V V +++T++ + + H +V
Sbjct: 830 GLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVM 889
Query: 289 FAPNTLLLATGSMDKTVNIWQ 309
F+P+ T S D+T+ +W+
Sbjct: 890 FSPDGSSFLTSSDDQTIRLWE 910
Score = 84.3 bits (207), Expect = 2e-16
Identities = 79/277 (28%), Positives = 127/277 (45%), Gaps = 40/277 (14%)
Query: 11 HGDDVNCCAFSFS--LLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGH- 67
H D+V CCAFS +ATCS+DK +++++ EL H+ H+ V+CC F+ S H
Sbjct: 656 HEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMT-GELVHT-YDEHSEQVNCCHFTNSSHH 713
Query: 68 -ILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNA 126
+LA+ S+D LW+ + M + S V C+FSPD LAS +ADGT+ LW+A
Sbjct: 714 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNS-VNHCRFSPDDKLLASCSADGTLKLWDA 772
Query: 127 QSYKLYRCGSVKDGSL-------------AACAFSPNGSFFVTGSSCGDLTVWDDKMRCL 173
S + +VK L C++S +G+ + + + ++D L
Sbjct: 773 TSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAK-NKIFLFDIHTSGL 831
Query: 174 HSE--KAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKY 231
E H I CDFS Q + + Q C V++W +
Sbjct: 832 LGEIHTGHHSTIQYCDFSPQ---------NHLAVVALSQYC-VELWNTDSRSKV------ 875
Query: 232 KSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDT 268
+ GH + V FS DG ++ S D+++ +++T
Sbjct: 876 -ADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 911
Score = 80.5 bits (197), Expect = 3e-15
Identities = 87/372 (23%), Positives = 149/372 (40%), Gaps = 57/372 (15%)
Query: 3 KLIHTLADHGDDVNCCAFSFS----LLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVH 58
+L+HT +H + VNCC F+ S LLAT S D ++L+ L + + + HT +V+
Sbjct: 690 ELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQ--KECRNTMFGHTNSVN 747
Query: 59 CCCFSPSGHILASCSTDGTTVLWNTENG---------QMLAVMEQPSGSP---VRVCQFS 106
C FSP +LASCS DGT LW+ + Q +E P V+ C +S
Sbjct: 748 HCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWS 807
Query: 107 PDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDG---SLAACAFSPNGSFFVTGSSCGDL 163
D + AA + L++ + L G + G ++ C FSP V S +
Sbjct: 808 ADGARIMV-AAKNKIFLFDIHTSGL--LGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCV 864
Query: 164 TVWDDKMRCL------HSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQV--- 214
+W+ R H H + + D SS S +Q ++ + ++ V
Sbjct: 865 ELWNTDSRSKVADCRGHLSWVHGV-MFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLK 923
Query: 215 ----------KIWIVSFTHILGFELKYKSTLSGHC--------APVLACAFSHDGQMLVS 256
++ +++ HI +L ++G A V C S Q +
Sbjct: 924 QEVDVVFQENEVMVLAVDHIRRLQL-----INGRTGQIDYLTEAQVSCCCLSPHLQYIAF 978
Query: 257 GSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFDLETLC 316
G + ++ + + I + QH + V F + L + S D + +W + L+
Sbjct: 979 GDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI 1038
Query: 317 QARRTEHQLKQF 328
R + +K F
Sbjct: 1039 FLRGHQETVKDF 1050
Score = 58.5 bits (140), Expect = 1e-08
Identities = 78/347 (22%), Positives = 133/347 (38%), Gaps = 70/347 (20%)
Query: 5 IHTLADHGDDVNCCAFS-FSLLATCSLDK-TIRLYSLRDFTELPHSPLKFHTYAVHCCCF 62
IHT H + C FS + LA +L + + L++ +++ + + H VH F
Sbjct: 835 IHT--GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKV--ADCRGHLSWVHGVMF 890
Query: 63 SPSGHILASCSTDGTTVLWNT--------------------ENGQMLAVMEQP------- 95
SP G + S D T LW T EN M+ ++
Sbjct: 891 SPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLIN 950
Query: 96 ---------SGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACA 146
+ + V C SP +A G +G + + + ++++ ++
Sbjct: 951 GRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQ 1010
Query: 147 FSPNGSFFVTGSSCGDLTVWDDKM-RCL----HSEKAHDLGITCCDFSSQPVSDGEQGLQ 201
F+ + ++ S ++ VW+ ++ +C+ H E D + L+
Sbjct: 1011 FTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRL----------------LK 1054
Query: 202 FFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDK 261
RL S D VK+W + I G + K H VL+C SHD S S DK
Sbjct: 1055 NSRLLSWSFDGTVKVWNI----ITGNKEK---DFVCHQGTVLSCDISHDATKFSSTSADK 1107
Query: 262 SVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
+ ++ + LH L H V AF+ ++ LLATG + + IW
Sbjct: 1108 TAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIW 1154
Score = 52.0 bits (123), Expect = 1e-06
Identities = 65/267 (24%), Positives = 105/267 (39%), Gaps = 42/267 (15%)
Query: 57 VHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGA 116
V CCC SP +A +G + N ++ Q + + QF+ D L S +
Sbjct: 964 VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHI-QFTADEKTLISSS 1022
Query: 117 ADGTVVLWNAQSYK-LYRCG---SVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRC 172
D + +WN Q K ++ G +VKD L S ++ S G + VW+ +
Sbjct: 1023 DDAEIQVWNWQLDKCIFLRGHQETVKDFRLL------KNSRLLSWSFDGTVKVWN--IIT 1074
Query: 173 LHSEK---AHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFEL 229
+ EK H + CD S + +S D KIW SF +L
Sbjct: 1075 GNKEKDFVCHQGTVLSCDISHDAT----------KFSSTSADKTAKIW--SFDLLLPLH- 1121
Query: 230 KYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHT--------LTQHT 281
L GH V AFS D +L +G + + +++ + +LH H
Sbjct: 1122 ----ELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHG 1177
Query: 282 RYVTTCAFAPN-TLLLATGSMDKTVNI 307
+VT F+P+ +L++ G K N+
Sbjct: 1178 GWVTDLCFSPDGKMLISAGGYIKWWNV 1204
Score = 50.8 bits (120), Expect = 3e-06
Identities = 59/298 (19%), Positives = 102/298 (34%), Gaps = 58/298 (19%)
Query: 53 HTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCL 112
H + C FSP H+ + LWNT++ +A S V FSPD +
Sbjct: 839 HHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHL-SWVHGVMFSPDGSSF 897
Query: 113 ASGAADGTVVLWNAQSY-------------------------------------KLYRCG 135
+ + D T+ LW + + +
Sbjct: 898 LTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQID 957
Query: 136 SVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD-DKMRCLHSEKAHDLGITCCDFSSQPVS 194
+ + ++ C SP+ + G G + + + R S H + F++ +
Sbjct: 958 YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 1017
Query: 195 DGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQML 254
L S D ++++W ++L L GH V + ++L
Sbjct: 1018 ----------LISSSDDAEIQVW--------NWQLDKCIFLRGHQETVKDFRLLKNSRLL 1059
Query: 255 VSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFDL 312
S S D +V V++ T N H V +C + + ++ S DKT IW FDL
Sbjct: 1060 -SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDL 1116
Score = 48.5 bits (114), Expect = 1e-05
Identities = 45/159 (28%), Positives = 68/159 (42%), Gaps = 14/159 (8%)
Query: 14 DVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCS 73
D++ A FS + S DKT +++S LP L+ H V C FS +LA+
Sbjct: 1092 DISHDATKFS---STSADKTAKIWSFDLL--LPLHELRGHNGCVRCSAFSVDSTLLATGD 1146
Query: 74 TDGTTVLWNTENGQMLAVMEQPS-------GSPVRVCQFSPDSTCLASGAADGTVVLWNA 126
+G +WN NG++L + S G V FSPD L S A G + WN
Sbjct: 1147 DNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLIS--AGGYIKWWNV 1204
Query: 127 QSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTV 165
+ + + +L SP+ +VT + G L +
Sbjct: 1205 VTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYI 1243
Score = 38.1 bits (87), Expect = 0.018
Identities = 36/113 (31%), Positives = 51/113 (45%), Gaps = 13/113 (11%)
Query: 5 IHTLADHGDDVNCCAFSF--SLLATCSLDKTIRLYSLRDFTELPH--SPLKFHTYAVH-- 58
+H L H V C AFS +LLAT + IR++++ + EL H +PL A H
Sbjct: 1120 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN-GELLHLCAPLSEEGAATHGG 1178
Query: 59 ---CCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPD 108
CFSP G +L S G WN G+ +G+ ++ SPD
Sbjct: 1179 WVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTF-YTNGTNLKKIHVSPD 1228
>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
sapiens]
Length = 1237
Score = 88.2 bits (217), Expect = 1e-17
Identities = 71/282 (25%), Positives = 118/282 (41%), Gaps = 22/282 (7%)
Query: 40 RDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSP 99
++ T L ++ HT AV+ CFS G +ASC D T ++ E G+ L ++
Sbjct: 590 KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHE-DE 648
Query: 100 VRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAF--SPNGSFFVTG 157
V C FS D +A+ + D V +WN+ + +L + C F S + TG
Sbjct: 649 VLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATG 708
Query: 158 SSCGDLTVWD-DKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKI 216
SS L +WD ++ C ++ H + C FS LASC D +K+
Sbjct: 709 SSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDK----------LLASCSADGTLKL 758
Query: 217 WIVSFT------HILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNT 270
W + ++ F L + V C++S DG ++ + +K + ++D +T
Sbjct: 759 WDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHT 817
Query: 271 ENILHTL-TQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFD 311
+L + T H + C F+P L V +W D
Sbjct: 818 SGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTD 859
Score = 85.5 bits (210), Expect = 1e-16
Identities = 75/321 (23%), Positives = 133/321 (41%), Gaps = 46/321 (14%)
Query: 11 HGDDVNCCAFSFS--LLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHI 68
H D V FS +A+C DKT++++ +L +K H V CC FS
Sbjct: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLE--IKAHEDEVLCCAFSTDDRF 660
Query: 69 LASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDS--TCLASGAADGTVVLWNA 126
+A+CS D +WN+ G+++ ++ S V C F+ S LA+G++D + LW+
Sbjct: 661 IATCSVDKKVKIWNSMTGELVHTYDEHS-EQVNCCHFTNSSHHLLLATGSSDCFLKLWDL 719
Query: 127 QSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDD-----------KMRCLHS 175
+ S+ C FSP+ + S+ G L +WD K L+
Sbjct: 720 NQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNL 779
Query: 176 EKAH---DLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYK 232
E ++ + CC +S +DG +I + + I F++
Sbjct: 780 EDPQEDMEVIVKCCSWS----ADG-----------------ARIMVAAKNKIFLFDIHTS 818
Query: 233 STL----SGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCA 288
L +GH + + C FS + V V +++T++ + + H +V
Sbjct: 819 GLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVM 878
Query: 289 FAPNTLLLATGSMDKTVNIWQ 309
F+P+ T S D+T+ +W+
Sbjct: 879 FSPDGSSFLTSSDDQTIRLWE 899
Score = 84.3 bits (207), Expect = 2e-16
Identities = 79/277 (28%), Positives = 127/277 (45%), Gaps = 40/277 (14%)
Query: 11 HGDDVNCCAFSFS--LLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGH- 67
H D+V CCAFS +ATCS+DK +++++ EL H+ H+ V+CC F+ S H
Sbjct: 645 HEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMT-GELVHT-YDEHSEQVNCCHFTNSSHH 702
Query: 68 -ILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNA 126
+LA+ S+D LW+ + M + S V C+FSPD LAS +ADGT+ LW+A
Sbjct: 703 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNS-VNHCRFSPDDKLLASCSADGTLKLWDA 761
Query: 127 QSYKLYRCGSVKDGSL-------------AACAFSPNGSFFVTGSSCGDLTVWDDKMRCL 173
S + +VK L C++S +G+ + + + ++D L
Sbjct: 762 TSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAK-NKIFLFDIHTSGL 820
Query: 174 HSE--KAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKY 231
E H I CDFS Q + + Q C V++W +
Sbjct: 821 LGEIHTGHHSTIQYCDFSPQ---------NHLAVVALSQYC-VELWNTDSRSKV------ 864
Query: 232 KSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDT 268
+ GH + V FS DG ++ S D+++ +++T
Sbjct: 865 -ADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 900
Score = 80.5 bits (197), Expect = 3e-15
Identities = 87/372 (23%), Positives = 149/372 (40%), Gaps = 57/372 (15%)
Query: 3 KLIHTLADHGDDVNCCAFSFS----LLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVH 58
+L+HT +H + VNCC F+ S LLAT S D ++L+ L + + + HT +V+
Sbjct: 679 ELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQ--KECRNTMFGHTNSVN 736
Query: 59 CCCFSPSGHILASCSTDGTTVLWNTENG---------QMLAVMEQPSGSP---VRVCQFS 106
C FSP +LASCS DGT LW+ + Q +E P V+ C +S
Sbjct: 737 HCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWS 796
Query: 107 PDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDG---SLAACAFSPNGSFFVTGSSCGDL 163
D + AA + L++ + L G + G ++ C FSP V S +
Sbjct: 797 ADGARIMV-AAKNKIFLFDIHTSGL--LGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCV 853
Query: 164 TVWDDKMRCL------HSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQV--- 214
+W+ R H H + + D SS S +Q ++ + ++ V
Sbjct: 854 ELWNTDSRSKVADCRGHLSWVHGV-MFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLK 912
Query: 215 ----------KIWIVSFTHILGFELKYKSTLSGHC--------APVLACAFSHDGQMLVS 256
++ +++ HI +L ++G A V C S Q +
Sbjct: 913 QEVDVVFQENEVMVLAVDHIRRLQL-----INGRTGQIDYLTEAQVSCCCLSPHLQYIAF 967
Query: 257 GSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFDLETLC 316
G + ++ + + I + QH + V F + L + S D + +W + L+
Sbjct: 968 GDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI 1027
Query: 317 QARRTEHQLKQF 328
R + +K F
Sbjct: 1028 FLRGHQETVKDF 1039
Score = 58.5 bits (140), Expect = 1e-08
Identities = 78/347 (22%), Positives = 133/347 (38%), Gaps = 70/347 (20%)
Query: 5 IHTLADHGDDVNCCAFS-FSLLATCSLDK-TIRLYSLRDFTELPHSPLKFHTYAVHCCCF 62
IHT H + C FS + LA +L + + L++ +++ + + H VH F
Sbjct: 824 IHT--GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKV--ADCRGHLSWVHGVMF 879
Query: 63 SPSGHILASCSTDGTTVLWNT--------------------ENGQMLAVMEQP------- 95
SP G + S D T LW T EN M+ ++
Sbjct: 880 SPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLIN 939
Query: 96 ---------SGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACA 146
+ + V C SP +A G +G + + + ++++ ++
Sbjct: 940 GRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQ 999
Query: 147 FSPNGSFFVTGSSCGDLTVWDDKM-RCL----HSEKAHDLGITCCDFSSQPVSDGEQGLQ 201
F+ + ++ S ++ VW+ ++ +C+ H E D + L+
Sbjct: 1000 FTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRL----------------LK 1043
Query: 202 FFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDK 261
RL S D VK+W + I G + K H VL+C SHD S S DK
Sbjct: 1044 NSRLLSWSFDGTVKVWNI----ITGNKEK---DFVCHQGTVLSCDISHDATKFSSTSADK 1096
Query: 262 SVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
+ ++ + LH L H V AF+ ++ LLATG + + IW
Sbjct: 1097 TAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIW 1143
Score = 52.0 bits (123), Expect = 1e-06
Identities = 65/267 (24%), Positives = 105/267 (39%), Gaps = 42/267 (15%)
Query: 57 VHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGA 116
V CCC SP +A +G + N ++ Q + + QF+ D L S +
Sbjct: 953 VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHI-QFTADEKTLISSS 1011
Query: 117 ADGTVVLWNAQSYK-LYRCG---SVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRC 172
D + +WN Q K ++ G +VKD L S ++ S G + VW+ +
Sbjct: 1012 DDAEIQVWNWQLDKCIFLRGHQETVKDFRLL------KNSRLLSWSFDGTVKVWN--IIT 1063
Query: 173 LHSEK---AHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFEL 229
+ EK H + CD S + +S D KIW SF +L
Sbjct: 1064 GNKEKDFVCHQGTVLSCDISHDAT----------KFSSTSADKTAKIW--SFDLLLPLH- 1110
Query: 230 KYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHT--------LTQHT 281
L GH V AFS D +L +G + + +++ + +LH H
Sbjct: 1111 ----ELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHG 1166
Query: 282 RYVTTCAFAPN-TLLLATGSMDKTVNI 307
+VT F+P+ +L++ G K N+
Sbjct: 1167 GWVTDLCFSPDGKMLISAGGYIKWWNV 1193
Score = 50.8 bits (120), Expect = 3e-06
Identities = 59/298 (19%), Positives = 102/298 (34%), Gaps = 58/298 (19%)
Query: 53 HTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCL 112
H + C FSP H+ + LWNT++ +A S V FSPD +
Sbjct: 828 HHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHL-SWVHGVMFSPDGSSF 886
Query: 113 ASGAADGTVVLWNAQSY-------------------------------------KLYRCG 135
+ + D T+ LW + + +
Sbjct: 887 LTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQID 946
Query: 136 SVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD-DKMRCLHSEKAHDLGITCCDFSSQPVS 194
+ + ++ C SP+ + G G + + + R S H + F++ +
Sbjct: 947 YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 1006
Query: 195 DGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQML 254
L S D ++++W ++L L GH V + ++L
Sbjct: 1007 ----------LISSSDDAEIQVW--------NWQLDKCIFLRGHQETVKDFRLLKNSRLL 1048
Query: 255 VSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFDL 312
S S D +V V++ T N H V +C + + ++ S DKT IW FDL
Sbjct: 1049 -SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDL 1105
Score = 48.5 bits (114), Expect = 1e-05
Identities = 45/159 (28%), Positives = 68/159 (42%), Gaps = 14/159 (8%)
Query: 14 DVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCS 73
D++ A FS + S DKT +++S LP L+ H V C FS +LA+
Sbjct: 1081 DISHDATKFS---STSADKTAKIWSFDLL--LPLHELRGHNGCVRCSAFSVDSTLLATGD 1135
Query: 74 TDGTTVLWNTENGQMLAVMEQPS-------GSPVRVCQFSPDSTCLASGAADGTVVLWNA 126
+G +WN NG++L + S G V FSPD L S A G + WN
Sbjct: 1136 DNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLIS--AGGYIKWWNV 1193
Query: 127 QSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTV 165
+ + + +L SP+ +VT + G L +
Sbjct: 1194 VTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYI 1232
Score = 38.1 bits (87), Expect = 0.018
Identities = 36/113 (31%), Positives = 51/113 (45%), Gaps = 13/113 (11%)
Query: 5 IHTLADHGDDVNCCAFSF--SLLATCSLDKTIRLYSLRDFTELPH--SPLKFHTYAVH-- 58
+H L H V C AFS +LLAT + IR++++ + EL H +PL A H
Sbjct: 1109 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN-GELLHLCAPLSEEGAATHGG 1167
Query: 59 ---CCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPD 108
CFSP G +L S G WN G+ +G+ ++ SPD
Sbjct: 1168 WVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTF-YTNGTNLKKIHVSPD 1217
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 87.8 bits (216), Expect = 2e-17
Identities = 85/305 (27%), Positives = 133/305 (43%), Gaps = 43/305 (14%)
Query: 46 PHSPLKF----HTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVR 101
P+ LKF HT AV FSP+G LAS S D +W +G+ + SG +
Sbjct: 33 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI---SGHKLG 89
Query: 102 VCQ--FSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSS 159
+ +S DS L S + D T+ +W+ S K + + C F+P + V+GS
Sbjct: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149
Query: 160 CGDLTVWDDKM-RCLHSEKAHDLGITCCDFS---SQPVSDGEQGLQFFRLASCGQ----- 210
+ +WD K +CL + AH ++ F+ S VS GL + GQ
Sbjct: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL 209
Query: 211 --DCQVKIWIVSFT----HILGFEL------------KYKSTLSGHCAPVLACAFSH--- 249
D + V F+ +IL L K T +GH C F++
Sbjct: 210 IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGH-KNEKYCIFANFSV 268
Query: 250 -DGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSM--DKTVN 306
G+ +VSGS D V +++ T+ I+ L HT V + A P ++A+ ++ DKT+
Sbjct: 269 TGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIK 328
Query: 307 IWQFD 311
+W+ D
Sbjct: 329 LWKSD 333
Score = 66.2 bits (160), Expect = 6e-11
Identities = 46/173 (26%), Positives = 81/173 (46%), Gaps = 13/173 (7%)
Query: 3 KLIHTLADHGDDVNCCAFS--FSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCC 60
K + TL H + V CC F+ +L+ + S D+++R++ ++ L P H+ V
Sbjct: 120 KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPA--HSDPVSAV 177
Query: 61 CFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGT 120
F+ G ++ S S DG +W+T +GQ L + PV +FSP+ + + D T
Sbjct: 178 HFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNT 237
Query: 121 VVLWNAQSYKLYRCGSVKDG--SLAACAFS----PNGSFFVTGSSCGDLTVWD 167
+ LW+ Y +C G + C F+ G + V+GS + +W+
Sbjct: 238 LKLWD---YSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWN 287
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 87.8 bits (216), Expect = 2e-17
Identities = 85/305 (27%), Positives = 133/305 (43%), Gaps = 43/305 (14%)
Query: 46 PHSPLKF----HTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVR 101
P+ LKF HT AV FSP+G LAS S D +W +G+ + SG +
Sbjct: 33 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI---SGHKLG 89
Query: 102 VCQ--FSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSS 159
+ +S DS L S + D T+ +W+ S K + + C F+P + V+GS
Sbjct: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149
Query: 160 CGDLTVWDDKM-RCLHSEKAHDLGITCCDFS---SQPVSDGEQGLQFFRLASCGQ----- 210
+ +WD K +CL + AH ++ F+ S VS GL + GQ
Sbjct: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL 209
Query: 211 --DCQVKIWIVSFT----HILGFEL------------KYKSTLSGHCAPVLACAFSH--- 249
D + V F+ +IL L K T +GH C F++
Sbjct: 210 IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGH-KNEKYCIFANFSV 268
Query: 250 -DGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSM--DKTVN 306
G+ +VSGS D V +++ T+ I+ L HT V + A P ++A+ ++ DKT+
Sbjct: 269 TGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIK 328
Query: 307 IWQFD 311
+W+ D
Sbjct: 329 LWKSD 333
Score = 66.2 bits (160), Expect = 6e-11
Identities = 46/173 (26%), Positives = 81/173 (46%), Gaps = 13/173 (7%)
Query: 3 KLIHTLADHGDDVNCCAFS--FSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCC 60
K + TL H + V CC F+ +L+ + S D+++R++ ++ L P H+ V
Sbjct: 120 KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPA--HSDPVSAV 177
Query: 61 CFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGT 120
F+ G ++ S S DG +W+T +GQ L + PV +FSP+ + + D T
Sbjct: 178 HFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNT 237
Query: 121 VVLWNAQSYKLYRCGSVKDG--SLAACAFS----PNGSFFVTGSSCGDLTVWD 167
+ LW+ Y +C G + C F+ G + V+GS + +W+
Sbjct: 238 LKLWD---YSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWN 287
>gi|21536371 telomerase-associated protein 1 [Homo sapiens]
Length = 2627
Score = 86.7 bits (213), Expect = 4e-17
Identities = 83/305 (27%), Positives = 135/305 (44%), Gaps = 29/305 (9%)
Query: 19 AFSFSLLATCSLDKTIRLYSLRDFTELPH--------SPLKFHTYAVHCCCFSPSGHILA 70
A S LLA+ S D T++L+ R PH + L+ H V CC FS G LA
Sbjct: 2019 ATSQELLASASEDFTVQLWP-RQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLA 2077
Query: 71 SCSTDGTTVLWNTENGQMLAVMEQPSGSP---VRVCQFSPDSTCLASGAADGTVVLWNAQ 127
+ D + + W+ + ++ V C ++ D+ L S ++DG+V LW+ +
Sbjct: 2078 TGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDNL-LISCSSDGSVGLWDPE 2136
Query: 128 SYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHDLGITCCD 187
S + R G A A + V+ S G L VWD + L S AH I+ C
Sbjct: 2137 SGQ--RLGQFLGHQSAVSAVAAVEEHVVSVSRDGTLKVWDHQGVELTSIPAHSGPISHCA 2194
Query: 188 FSSQPVSDGEQGLQFFRLASCGQDCQVKIW---IVSFTHILGFELKYKSTLSGHCAPVLA 244
+ +P + G+ G + + + G D ++W +V TH TL GH PV A
Sbjct: 2195 AAMEPRAAGQPGSELL-VVTVGLDGATRLWHPLLVCQTH----------TLLGHSGPVRA 2243
Query: 245 CAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKT 304
A S ++++ S D SV ++ E + + + VT A+AP+ + +G+
Sbjct: 2244 AAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSAAVTAVAWAPDGSMAVSGNQAGE 2303
Query: 305 VNIWQ 309
+ +WQ
Sbjct: 2304 LILWQ 2308
Score = 74.3 bits (181), Expect = 2e-13
Identities = 81/317 (25%), Positives = 134/317 (42%), Gaps = 25/317 (7%)
Query: 2 VKLIHTLADHGDDVNCCAFSF--SLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHC 59
+K+ L G + AF+ ++A LD + L++ R+ L P H V
Sbjct: 1832 LKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPA--HHGFVAA 1889
Query: 60 CCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADG 119
F +G L + DG +W+ G+ + S SP SPD +A G
Sbjct: 1890 ALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGHLGSLSLSPALSVALSPDGDRVAVGYRAD 1949
Query: 120 TVVLWNAQSYKLYRCGSVKDGSLAACAF-SPNGSFFVTGSSCGDLTVWDDKMRCLHSEKA 178
+ ++ S G D +++A A+ SP V+G+ G L W K L S
Sbjct: 1950 GIRIYKISSGSQGAQGQALDVAVSALAWLSP--KVLVSGAEDGSLQGWALKECSLQS--- 2004
Query: 179 HDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIW---IVSFTHILGFELKYKSTL 235
+ +PV + LAS +D V++W +++ H + + L
Sbjct: 2005 ----LWLLSRFQKPVLGLATSQEL--LASASEDFTVQLWPRQLLTRPH-KAEDFPCGTEL 2057
Query: 236 SGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTEN---ILHTLTQ-HTRYVTTCAFAP 291
GH PV C+FS DG L +G D+S++ +D T ++H+ H +VT CA+
Sbjct: 2058 RGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTK 2117
Query: 292 NTLLLATGSMDKTVNIW 308
+ LL++ S D +V +W
Sbjct: 2118 DNLLISCSS-DGSVGLW 2133
Score = 61.2 bits (147), Expect = 2e-09
Identities = 63/257 (24%), Positives = 104/257 (40%), Gaps = 24/257 (9%)
Query: 13 DDVNCCAF-SFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILAS 71
D ++ C F S L + D + L+ L+ + + K H Y + CC SP +LA+
Sbjct: 1719 DGISACLFLSDDTLFLTAFDGLLELWDLQHGCRVLQT--KAHQYQITGCCLSPDCRLLAT 1776
Query: 72 CSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKL 131
G LW+T GQ+ P + F P+ +A+G+ G++ + K+
Sbjct: 1777 VCLGGCLKLWDTVRGQLAFQHTYPKS--LNCVAFHPEGQVIATGSWAGSISFFQVDGLKV 1834
Query: 132 YRCGSVKDGSLAACAFSPNGSFFVTG--SSCGDLTVWDDKMRCLHSEKAHDLGITCCDFS 189
+ S+ AF+ G G S +L W + R L + AH + F
Sbjct: 1835 TKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWREGAR-LAAFPAHHGFVAAALFL 1893
Query: 190 SQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSH 249
G Q L + G+D +V++W S LG + +LS +P L+ A S
Sbjct: 1894 -------HAGCQ---LLTAGEDGKVQVWSGS----LGRPRGHLGSLS--LSPALSVALSP 1937
Query: 250 DGQMLVSGSVDKSVIVY 266
DG + G + +Y
Sbjct: 1938 DGDRVAVGYRADGIRIY 1954
Score = 51.2 bits (121), Expect = 2e-06
Identities = 58/227 (25%), Positives = 98/227 (43%), Gaps = 23/227 (10%)
Query: 84 ENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLA 143
+N Q ++ S SP V FS + A G A+GTV L + ++++ + ++
Sbjct: 1664 KNQQSSSLSLAVSSSPTAVA-FSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGIS 1722
Query: 144 ACAFSPNGSFFVTGSSCGDLTVWDDKMRC-LHSEKAHDLGIT-CCDFSSQPVSDGEQGLQ 201
AC F + + F+T G L +WD + C + KAH IT CC +S + L
Sbjct: 1723 ACLFLSDDTLFLTAFD-GLLELWDLQHGCRVLQTKAHQYQITGCC------LSPDCRLLA 1775
Query: 202 FFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDK 261
L C +K+W + L F+ Y +L+ AF +GQ++ +GS
Sbjct: 1776 TVCLGGC-----LKLWD-TVRGQLAFQHTYPKSLN-------CVAFHPEGQVIATGSWAG 1822
Query: 262 SVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
S+ + + + L + T AF ++A G +D V +W
Sbjct: 1823 SISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELW 1869
Score = 47.0 bits (110), Expect = 4e-05
Identities = 28/101 (27%), Positives = 47/101 (46%), Gaps = 1/101 (0%)
Query: 68 ILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQ 127
++ + DG T LW+ + SG PVR S S + + + DG+V LW
Sbjct: 2210 LVVTVGLDGATRLWHPLLVCQTHTLLGHSG-PVRAAAVSETSGLMLTASEDGSVRLWQVP 2268
Query: 128 SYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDD 168
C ++ A A++P+GS V+G+ G+L +W +
Sbjct: 2269 KEADDTCIPRSSAAVTAVAWAPDGSMAVSGNQAGELILWQE 2309
Score = 29.6 bits (65), Expect = 6.3
Identities = 42/181 (23%), Positives = 73/181 (40%), Gaps = 38/181 (20%)
Query: 141 SLAACAFSPNGSFFVTGSSCG-----DLTVWDDKMRCLHSEKAHDLGITCCDFSSQPVSD 195
S A AFS NG G++ G DL W ++ + GI+ C F +SD
Sbjct: 1678 SPTAVAFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCD----GISACLF----LSD 1729
Query: 196 GEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTL---SGHCAPVLACAFSHDGQ 252
L F D +++W +L++ + H + C S D +
Sbjct: 1730 DTLFLTAF-------DGLLELW----------DLQHGCRVLQTKAHQYQITGCCLSPDCR 1772
Query: 253 MLVSGSVDKSVIVYDTNTENILHTLTQHT--RYVTTCAFAPNTLLLATGSMDKTVNIWQF 310
+L + + + ++DT + QHT + + AF P ++ATGS +++ +Q
Sbjct: 1773 LLATVCLGGCLKLWDTVRGQLAF---QHTYPKSLNCVAFHPEGQVIATGSWAGSISFFQV 1829
Query: 311 D 311
D
Sbjct: 1830 D 1830
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 86.7 bits (213), Expect = 4e-17
Identities = 82/304 (26%), Positives = 129/304 (42%), Gaps = 40/304 (13%)
Query: 44 ELPHSP-------LKFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPS 96
E+P +P L HT AV FSP+G LAS S D ++W +G+ +
Sbjct: 24 EVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTL-YGH 82
Query: 97 GSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVT 156
+ +S DS+ L S + D T+ LW+ +S K + + C F+P + ++
Sbjct: 83 NLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIIS 142
Query: 157 GSSCGDLTVWDDKM-RCLHSEKAHDLGITCCDFS---SQPVSDGEQGLQFFRLASCGQ-- 210
GS + +W+ K +CL + AH ++ F+ S VS GL A+ GQ
Sbjct: 143 GSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCL 202
Query: 211 -----DCQVKIWIVSF--------THILGFELKYKSTLSGHCAPVLA-------CAFSH- 249
D + V F T L LK G C C F++
Sbjct: 203 KTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANF 262
Query: 250 ---DGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSM--DKT 304
G+ +VSGS D V +++ T+ I+ L HT V + A P L+A+ ++ DKT
Sbjct: 263 SVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKT 322
Query: 305 VNIW 308
+ +W
Sbjct: 323 IKLW 326
Score = 83.6 bits (205), Expect = 4e-16
Identities = 65/227 (28%), Positives = 105/227 (46%), Gaps = 20/227 (8%)
Query: 104 QFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDL 163
+FSP+ LAS +AD +++W A K + + ++ A+S + S V+ S L
Sbjct: 48 KFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTL 107
Query: 164 TVWDDKM-RCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFT 222
+WD + +CL + K H + CC+F+ P S+ + S D VKIW V
Sbjct: 108 KLWDVRSGKCLKTLKGHSNYVFCCNFN--PPSN--------LIISGSFDETVKIWEVKTG 157
Query: 223 HILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTR 282
L TLS H PV A F+ G ++VSGS D ++D + L TL
Sbjct: 158 KCL-------KTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDN 210
Query: 283 Y-VTTCAFAPNTLLLATGSMDKTVNIWQFDLETLCQARRTEHQLKQF 328
V+ F+PN + T ++D T+ +W + C T H+ +++
Sbjct: 211 PPVSFVKFSPNGKYILTATLDNTLKLWDYS-RGRCLKTYTGHKNEKY 256
Score = 66.2 bits (160), Expect = 6e-11
Identities = 47/173 (27%), Positives = 81/173 (46%), Gaps = 13/173 (7%)
Query: 3 KLIHTLADHGDDVNCCAFS--FSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCC 60
K + TL H + V CC F+ +L+ + S D+T++++ ++ L L H+ V
Sbjct: 116 KCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCL--KTLSAHSDPVSAV 173
Query: 61 CFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGT 120
F+ SG ++ S S DG +W+ +GQ L + PV +FSP+ + + D T
Sbjct: 174 HFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNT 233
Query: 121 VVLWNAQSYKLYRCGSVKDG--SLAACAFS----PNGSFFVTGSSCGDLTVWD 167
+ LW+ Y RC G + C F+ G + V+GS + +W+
Sbjct: 234 LKLWD---YSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWN 283
Score = 35.0 bits (79), Expect = 0.15
Identities = 19/57 (33%), Positives = 31/57 (54%)
Query: 252 QMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
Q+ +S S ++S V + + TL HT V++ F+PN LA+ S D+ + IW
Sbjct: 12 QLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIW 68
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 83.2 bits (204), Expect = 5e-16
Identities = 70/255 (27%), Positives = 108/255 (42%), Gaps = 31/255 (12%)
Query: 61 CFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGT 120
C G+ + S S D T +W+ G+ L + +G V + SG+ D T
Sbjct: 268 CLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG---VWSSQMRDNIIISGSTDRT 324
Query: 121 VVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD-DKMRCLHSEKAH 179
+ +WNA++ + ++ + + V+GS L VWD + +CLH H
Sbjct: 325 LKVWNAETGECIH--TLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGH 382
Query: 180 DLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHC 239
+ C + + R+ S D VK+W L TL GH
Sbjct: 383 VAAVRCVQYDGR------------RVVSGAYDFMVKVWDPETETCL-------HTLQGHT 423
Query: 240 APVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATG 299
V + F DG +VSGS+D S+ V+D T N +HTLT H + N +L +G
Sbjct: 424 NRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSG 479
Query: 300 SMDKTVNIWQFDLET 314
+ D TV IW D++T
Sbjct: 480 NADSTVKIW--DIKT 492
Score = 72.0 bits (175), Expect = 1e-12
Identities = 59/215 (27%), Positives = 97/215 (45%), Gaps = 29/215 (13%)
Query: 112 LASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM- 170
+ SG+ D T+ +W+A + K R G + + N ++GS+ L VW+ +
Sbjct: 276 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETG 333
Query: 171 RCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELK 230
C+H+ H + C + R+ S +D +++W + L
Sbjct: 334 ECIHTLYGHTSTVRCMHLHEK------------RVVSGSRDATLRVWDIETGQCL----- 376
Query: 231 YKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFA 290
L GH A V + DG+ +VSG+ D V V+D TE LHTL HT V + F
Sbjct: 377 --HVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF- 431
Query: 291 PNTLLLATGSMDKTVNIWQFDLET-LCQARRTEHQ 324
+ + + +GS+D ++ +W D+ET C T HQ
Sbjct: 432 -DGIHVVSGSLDTSIRVW--DVETGNCIHTLTGHQ 463
Score = 67.8 bits (164), Expect = 2e-11
Identities = 84/313 (26%), Positives = 132/313 (42%), Gaps = 41/313 (13%)
Query: 8 LADHGDDV-NCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSG 66
L H D V C F + + + S D T++++S T L HT V
Sbjct: 258 LKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSA--VTGKCLRTLVGHTGGVWSS--QMRD 313
Query: 67 HILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNA 126
+I+ S STD T +WN E G+ + + + S VR + SG+ D T+ +W+
Sbjct: 314 NIIISGSTDRTLKVWNAETGECIHTLYGHT-STVRCMHLHEKR--VVSGSRDATLRVWDI 370
Query: 127 QSYKLYRCGSVKDGSLAAC-AFSPNGSFFVTGSSCGDLTVWDDKMR-CLHSEKAHDLGIT 184
++ + C V G +AA +G V+G+ + VWD + CLH+ + H +
Sbjct: 371 ETGQ---CLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 427
Query: 185 CCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLA 244
F V G D +++W V + + TL+GH + L
Sbjct: 428 SLQFDGIHVVSGSL------------DTSIRVWDVETGNCI-------HTLTGHQS--LT 466
Query: 245 CAFSHDGQMLVSGSVDKSVIVYDTNTENILHTL---TQHTRYVTTCAFAPNTLLLATGSM 301
+LVSG+ D +V ++D T L TL +H VT F N ++ T S
Sbjct: 467 SGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVI--TSSD 524
Query: 302 DKTVNIWQFDLET 314
D TV +W DL+T
Sbjct: 525 DGTVKLW--DLKT 535
Score = 46.6 bits (109), Expect = 5e-05
Identities = 42/189 (22%), Positives = 74/189 (39%), Gaps = 13/189 (6%)
Query: 5 IHTLADHGDDVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSP 64
IHTL H V C + + S D T+R++ + T L H AV C +
Sbjct: 336 IHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIE--TGQCLHVLMGHVAAVRCVQY-- 391
Query: 65 SGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLW 124
G + S + D +W+ E L ++ G RV D + SG+ D ++ +W
Sbjct: 392 DGRRVVSGAYDFMVKVWDPETETCLHTLQ---GHTNRVYSLQFDGIHVVSGSLDTSIRVW 448
Query: 125 NAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDK----MRCLHSEKAHD 180
+ ++ + + N V+G++ + +WD K ++ L H
Sbjct: 449 DVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQ 506
Query: 181 LGITCCDFS 189
+TC F+
Sbjct: 507 SAVTCLQFN 515
Score = 43.5 bits (101), Expect = 4e-04
Identities = 33/132 (25%), Positives = 58/132 (43%), Gaps = 10/132 (7%)
Query: 5 IHTLADHGDDVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSP 64
+HTL H + V F + + SLD +IR++ + + HT H S
Sbjct: 416 LHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCI-------HTLTGHQSLTSG 468
Query: 65 ---SGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTV 121
+IL S + D T +W+ + GQ L ++ P+ V + + + + DGTV
Sbjct: 469 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV 528
Query: 122 VLWNAQSYKLYR 133
LW+ ++ + R
Sbjct: 529 KLWDLKTGEFIR 540
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 83.2 bits (204), Expect = 5e-16
Identities = 70/255 (27%), Positives = 108/255 (42%), Gaps = 31/255 (12%)
Query: 61 CFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGT 120
C G+ + S S D T +W+ G+ L + +G V + SG+ D T
Sbjct: 386 CLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG---VWSSQMRDNIIISGSTDRT 442
Query: 121 VVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD-DKMRCLHSEKAH 179
+ +WNA++ + ++ + + V+GS L VWD + +CLH H
Sbjct: 443 LKVWNAETGECIH--TLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGH 500
Query: 180 DLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHC 239
+ C + + R+ S D VK+W L TL GH
Sbjct: 501 VAAVRCVQYDGR------------RVVSGAYDFMVKVWDPETETCL-------HTLQGHT 541
Query: 240 APVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATG 299
V + F DG +VSGS+D S+ V+D T N +HTLT H + N +L +G
Sbjct: 542 NRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSG 597
Query: 300 SMDKTVNIWQFDLET 314
+ D TV IW D++T
Sbjct: 598 NADSTVKIW--DIKT 610
Score = 72.0 bits (175), Expect = 1e-12
Identities = 59/215 (27%), Positives = 97/215 (45%), Gaps = 29/215 (13%)
Query: 112 LASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM- 170
+ SG+ D T+ +W+A + K R G + + N ++GS+ L VW+ +
Sbjct: 394 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETG 451
Query: 171 RCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELK 230
C+H+ H + C + R+ S +D +++W + L
Sbjct: 452 ECIHTLYGHTSTVRCMHLHEK------------RVVSGSRDATLRVWDIETGQCL----- 494
Query: 231 YKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFA 290
L GH A V + DG+ +VSG+ D V V+D TE LHTL HT V + F
Sbjct: 495 --HVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF- 549
Query: 291 PNTLLLATGSMDKTVNIWQFDLET-LCQARRTEHQ 324
+ + + +GS+D ++ +W D+ET C T HQ
Sbjct: 550 -DGIHVVSGSLDTSIRVW--DVETGNCIHTLTGHQ 581
Score = 67.8 bits (164), Expect = 2e-11
Identities = 84/313 (26%), Positives = 132/313 (42%), Gaps = 41/313 (13%)
Query: 8 LADHGDDV-NCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSG 66
L H D V C F + + + S D T++++S T L HT V
Sbjct: 376 LKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSA--VTGKCLRTLVGHTGGVWSS--QMRD 431
Query: 67 HILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNA 126
+I+ S STD T +WN E G+ + + + S VR + SG+ D T+ +W+
Sbjct: 432 NIIISGSTDRTLKVWNAETGECIHTLYGHT-STVRCMHLHEKR--VVSGSRDATLRVWDI 488
Query: 127 QSYKLYRCGSVKDGSLAAC-AFSPNGSFFVTGSSCGDLTVWDDKMR-CLHSEKAHDLGIT 184
++ + C V G +AA +G V+G+ + VWD + CLH+ + H +
Sbjct: 489 ETGQ---CLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 545
Query: 185 CCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLA 244
F V G D +++W V + + TL+GH + L
Sbjct: 546 SLQFDGIHVVSGSL------------DTSIRVWDVETGNCI-------HTLTGHQS--LT 584
Query: 245 CAFSHDGQMLVSGSVDKSVIVYDTNTENILHTL---TQHTRYVTTCAFAPNTLLLATGSM 301
+LVSG+ D +V ++D T L TL +H VT F N ++ T S
Sbjct: 585 SGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVI--TSSD 642
Query: 302 DKTVNIWQFDLET 314
D TV +W DL+T
Sbjct: 643 DGTVKLW--DLKT 653
Score = 46.6 bits (109), Expect = 5e-05
Identities = 42/189 (22%), Positives = 74/189 (39%), Gaps = 13/189 (6%)
Query: 5 IHTLADHGDDVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSP 64
IHTL H V C + + S D T+R++ + T L H AV C +
Sbjct: 454 IHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIE--TGQCLHVLMGHVAAVRCVQY-- 509
Query: 65 SGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLW 124
G + S + D +W+ E L ++ G RV D + SG+ D ++ +W
Sbjct: 510 DGRRVVSGAYDFMVKVWDPETETCLHTLQ---GHTNRVYSLQFDGIHVVSGSLDTSIRVW 566
Query: 125 NAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDK----MRCLHSEKAHD 180
+ ++ + + N V+G++ + +WD K ++ L H
Sbjct: 567 DVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQ 624
Query: 181 LGITCCDFS 189
+TC F+
Sbjct: 625 SAVTCLQFN 633
Score = 43.5 bits (101), Expect = 4e-04
Identities = 33/132 (25%), Positives = 58/132 (43%), Gaps = 10/132 (7%)
Query: 5 IHTLADHGDDVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSP 64
+HTL H + V F + + SLD +IR++ + + HT H S
Sbjct: 534 LHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCI-------HTLTGHQSLTSG 586
Query: 65 ---SGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTV 121
+IL S + D T +W+ + GQ L ++ P+ V + + + + DGTV
Sbjct: 587 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV 646
Query: 122 VLWNAQSYKLYR 133
LW+ ++ + R
Sbjct: 647 KLWDLKTGEFIR 658
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 83.2 bits (204), Expect = 5e-16
Identities = 70/255 (27%), Positives = 108/255 (42%), Gaps = 31/255 (12%)
Query: 61 CFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGT 120
C G+ + S S D T +W+ G+ L + +G V + SG+ D T
Sbjct: 306 CLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG---VWSSQMRDNIIISGSTDRT 362
Query: 121 VVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD-DKMRCLHSEKAH 179
+ +WNA++ + ++ + + V+GS L VWD + +CLH H
Sbjct: 363 LKVWNAETGECIH--TLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGH 420
Query: 180 DLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHC 239
+ C + + R+ S D VK+W L TL GH
Sbjct: 421 VAAVRCVQYDGR------------RVVSGAYDFMVKVWDPETETCL-------HTLQGHT 461
Query: 240 APVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATG 299
V + F DG +VSGS+D S+ V+D T N +HTLT H + N +L +G
Sbjct: 462 NRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSG 517
Query: 300 SMDKTVNIWQFDLET 314
+ D TV IW D++T
Sbjct: 518 NADSTVKIW--DIKT 530
Score = 72.0 bits (175), Expect = 1e-12
Identities = 59/215 (27%), Positives = 97/215 (45%), Gaps = 29/215 (13%)
Query: 112 LASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM- 170
+ SG+ D T+ +W+A + K R G + + N ++GS+ L VW+ +
Sbjct: 314 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETG 371
Query: 171 RCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELK 230
C+H+ H + C + R+ S +D +++W + L
Sbjct: 372 ECIHTLYGHTSTVRCMHLHEK------------RVVSGSRDATLRVWDIETGQCL----- 414
Query: 231 YKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFA 290
L GH A V + DG+ +VSG+ D V V+D TE LHTL HT V + F
Sbjct: 415 --HVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF- 469
Query: 291 PNTLLLATGSMDKTVNIWQFDLET-LCQARRTEHQ 324
+ + + +GS+D ++ +W D+ET C T HQ
Sbjct: 470 -DGIHVVSGSLDTSIRVW--DVETGNCIHTLTGHQ 501
Score = 67.8 bits (164), Expect = 2e-11
Identities = 84/313 (26%), Positives = 132/313 (42%), Gaps = 41/313 (13%)
Query: 8 LADHGDDV-NCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSG 66
L H D V C F + + + S D T++++S T L HT V
Sbjct: 296 LKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSA--VTGKCLRTLVGHTGGVWSS--QMRD 351
Query: 67 HILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNA 126
+I+ S STD T +WN E G+ + + + S VR + SG+ D T+ +W+
Sbjct: 352 NIIISGSTDRTLKVWNAETGECIHTLYGHT-STVRCMHLHEKR--VVSGSRDATLRVWDI 408
Query: 127 QSYKLYRCGSVKDGSLAAC-AFSPNGSFFVTGSSCGDLTVWDDKMR-CLHSEKAHDLGIT 184
++ + C V G +AA +G V+G+ + VWD + CLH+ + H +
Sbjct: 409 ETGQ---CLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 465
Query: 185 CCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLA 244
F V G D +++W V + + TL+GH + L
Sbjct: 466 SLQFDGIHVVSGSL------------DTSIRVWDVETGNCI-------HTLTGHQS--LT 504
Query: 245 CAFSHDGQMLVSGSVDKSVIVYDTNTENILHTL---TQHTRYVTTCAFAPNTLLLATGSM 301
+LVSG+ D +V ++D T L TL +H VT F N ++ T S
Sbjct: 505 SGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVI--TSSD 562
Query: 302 DKTVNIWQFDLET 314
D TV +W DL+T
Sbjct: 563 DGTVKLW--DLKT 573
Score = 46.6 bits (109), Expect = 5e-05
Identities = 42/189 (22%), Positives = 74/189 (39%), Gaps = 13/189 (6%)
Query: 5 IHTLADHGDDVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSP 64
IHTL H V C + + S D T+R++ + T L H AV C +
Sbjct: 374 IHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIE--TGQCLHVLMGHVAAVRCVQY-- 429
Query: 65 SGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLW 124
G + S + D +W+ E L ++ G RV D + SG+ D ++ +W
Sbjct: 430 DGRRVVSGAYDFMVKVWDPETETCLHTLQ---GHTNRVYSLQFDGIHVVSGSLDTSIRVW 486
Query: 125 NAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDK----MRCLHSEKAHD 180
+ ++ + + N V+G++ + +WD K ++ L H
Sbjct: 487 DVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQ 544
Query: 181 LGITCCDFS 189
+TC F+
Sbjct: 545 SAVTCLQFN 553
Score = 43.5 bits (101), Expect = 4e-04
Identities = 33/132 (25%), Positives = 58/132 (43%), Gaps = 10/132 (7%)
Query: 5 IHTLADHGDDVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSP 64
+HTL H + V F + + SLD +IR++ + + HT H S
Sbjct: 454 LHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCI-------HTLTGHQSLTSG 506
Query: 65 ---SGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTV 121
+IL S + D T +W+ + GQ L ++ P+ V + + + + DGTV
Sbjct: 507 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV 566
Query: 122 VLWNAQSYKLYR 133
LW+ ++ + R
Sbjct: 567 KLWDLKTGEFIR 578
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 81.6 bits (200), Expect = 1e-15
Identities = 70/213 (32%), Positives = 98/213 (46%), Gaps = 16/213 (7%)
Query: 8 LADHGDDVNCCAFS--FSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPS 65
L H V +FS + L + S D T+RL+SL+ FT L K H Y V FSP
Sbjct: 539 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVG--YKGHNYPVWDTQFSPY 596
Query: 66 GHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWN 125
G+ S D LW T++ Q L + V +F P+S +A+G+AD TV LW+
Sbjct: 597 GYYFVSGGHDRVARLWATDHYQPLRIFAGHLAD-VNCTRFHPNSNYVATGSADRTVRLWD 655
Query: 126 AQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCLHSE-KAHDLGIT 184
+ R + G + + FSPNG F TG++ G + +WD + E K H +
Sbjct: 656 VLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVC 715
Query: 185 CCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIW 217
FS DGE LAS D V++W
Sbjct: 716 SLRFS----RDGE------ILASGSMDNTVRLW 738
Score = 79.0 bits (193), Expect = 9e-15
Identities = 69/248 (27%), Positives = 110/248 (44%), Gaps = 24/248 (9%)
Query: 73 STDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKLY 132
S D + + + L ++ SG PV FSPD L S + DGTV LW+ Q++
Sbjct: 520 SDDVLERIMDEKTASELKILYGHSG-PVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCL 578
Query: 133 RCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVW-DDKMRCLHSEKAHDLGITCCDFSSQ 191
+ + FSP G +FV+G +W D + L H + C F
Sbjct: 579 VGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRF--H 636
Query: 192 PVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDG 251
P S+ +A+ D V++W V + + +GH P+ + FS +G
Sbjct: 637 PNSN--------YVATGSADRTVRLWDVLNGNCVRI-------FTGHKGPIHSLTFSPNG 681
Query: 252 QMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQF- 310
+ L +G+ D V+++D ++ L HT V + F+ + +LA+GSMD TV +W
Sbjct: 682 RFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAI 741
Query: 311 ----DLET 314
DLET
Sbjct: 742 KAFEDLET 749
Score = 34.7 bits (78), Expect = 0.19
Identities = 37/120 (30%), Positives = 46/120 (38%), Gaps = 42/120 (35%)
Query: 5 IHTLADHGDDVNCCAF--SFSLLATCSLDKTIRLYSL------RDFT-------ELPHSP 49
+ A H DVNC F + + +AT S D+T+RL+ + R FT L SP
Sbjct: 620 LRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSP 679
Query: 50 ---------------------------LKFHTYAVHCCCFSPSGHILASCSTDGTTVLWN 82
LK HT V FS G ILAS S D T LW+
Sbjct: 680 NGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 79.7 bits (195), Expect = 5e-15
Identities = 77/298 (25%), Positives = 120/298 (40%), Gaps = 43/298 (14%)
Query: 50 LKFHTYAVHCCCFSPSGHILASCSTDGTTVLWN-----TENGQMLAV--------MEQPS 96
L+ H V C ++P +LAS S D T +WN T L + + PS
Sbjct: 165 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPS 224
Query: 97 GSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVT 156
V ++ + T LA+G+ DG +W G K G + A ++ G+F ++
Sbjct: 225 NKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHK-GPIFALKWNKKGNFILS 283
Query: 157 GSSCGDLTVWDDKMRCLHSEKAHDLGITCCDFSSQPVSDGE-QGLQFFRLASCGQDCQVK 215
+WD H+ +A F S P D + Q F ASC D +
Sbjct: 284 AGVDKTTIIWD-----AHTGEAKQQ----FPFHSAPALDVDWQSNNTF--ASCSTDMCIH 332
Query: 216 IWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILH 275
+ LG + K T GH V A + G +L S S D ++ ++ +N +H
Sbjct: 333 VCK------LGQDRPIK-TFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVH 385
Query: 276 TLTQHTRYVTTCAFAPN---------TLLLATGSMDKTVNIWQFDLETLCQARRTEHQ 324
L H + + T ++P L+LA+ S D TV +W D +C T+HQ
Sbjct: 386 DLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVD-RGICIHTLTKHQ 442
Score = 67.8 bits (164), Expect = 2e-11
Identities = 65/256 (25%), Positives = 107/256 (41%), Gaps = 16/256 (6%)
Query: 23 SLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVLWN 82
+LLAT S D R+++ S L H + ++ G+ + S D TT++W+
Sbjct: 238 TLLATGSYDGFARIWTKDGNLA---STLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWD 294
Query: 83 TENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSL 142
G+ A + P S + + AS + D + + + + +
Sbjct: 295 AHTGE--AKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEV 352
Query: 143 AACAFSPNGSFFVTGSSCGDLTVWDDKM-RCLHSEKAHDLGITCCDFSSQPVSDGEQGLQ 201
A + P G+ + S L +W K C+H +AH+ I +S P G
Sbjct: 353 NAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWS--PTGPGTNNPN 410
Query: 202 F-FRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVD 260
LAS D V++W V + TL+ H PV + AFS DG+ L SGS D
Sbjct: 411 ANLMLASASFDSTVRLWDVDRGICI-------HTLTKHQEPVYSVAFSPDGRYLASGSFD 463
Query: 261 KSVIVYDTNTENILHT 276
K V +++T T ++H+
Sbjct: 464 KCVHIWNTQTGALVHS 479
Score = 61.6 bits (148), Expect = 1e-09
Identities = 51/174 (29%), Positives = 81/174 (46%), Gaps = 15/174 (8%)
Query: 5 IHTLADHGDDVNCCAF--SFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCF 62
I T H ++VN + + +LLA+CS D T++++S++ H L+ H ++ +
Sbjct: 342 IKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQ-DNCVHD-LQAHNKEIYTIKW 399
Query: 63 SPSGH---------ILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLA 113
SP+G +LAS S D T LW+ + G + + + PV FSPD LA
Sbjct: 400 SPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQ-EPVYSVAFSPDGRYLA 458
Query: 114 SGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD 167
SG+ D V +WN Q+ L G C ++ G +S G + V D
Sbjct: 459 SGSFDKCVHIWNTQTGALVHSYRGTGGIFEVC-WNAAGDKVGASASDGSVCVLD 511
Score = 54.3 bits (129), Expect = 2e-07
Identities = 41/162 (25%), Positives = 72/162 (44%), Gaps = 12/162 (7%)
Query: 21 SFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVL 80
S + A+CS D I + L + P + HT V+ + P+G++LASCS D T +
Sbjct: 318 SNNTFASCSTDMCIHVCKLGQ--DRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKI 375
Query: 81 WNTENGQMLAVMEQPSGSPVRVCQFSPD---------STCLASGAADGTVVLWNAQSYKL 131
W+ + + + Q + ++SP + LAS + D TV LW+
Sbjct: 376 WSMKQDNCVHDL-QAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGIC 434
Query: 132 YRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCL 173
+ + + AFSP+G + +GS + +W+ + L
Sbjct: 435 IHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGAL 476
>gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo
sapiens]
Length = 421
Score = 78.6 bits (192), Expect = 1e-14
Identities = 68/225 (30%), Positives = 96/225 (42%), Gaps = 22/225 (9%)
Query: 53 HTYAVHCCCFSPSGH-ILASCSTDGTTVLWNT-ENGQMLAVMEQPSGSPVRVCQFSPDST 110
HT V F+P G IL S S D T +W+ ++G M+ V+ V C FSPDS+
Sbjct: 169 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNW-VYSCAFSPDSS 227
Query: 111 CLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM 170
L S A V LWN Y + R + AC FSP+G+ T S + +WD
Sbjct: 228 MLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHN 287
Query: 171 RCLHSEKAHDLGITCCDFSS-------QPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTH 223
+ E H F+ + VS GL +AS D V+ W +
Sbjct: 288 GDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGL---HVASLADDKMVRFWRID--- 341
Query: 224 ILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDT 268
+ ++ +G C CAFS DG +L +G+ D SV + T
Sbjct: 342 -EDYPVQVAPLSNGLC-----CAFSTDGSVLAAGTHDGSVYFWAT 380
Score = 63.9 bits (154), Expect = 3e-10
Identities = 51/177 (28%), Positives = 77/177 (43%), Gaps = 18/177 (10%)
Query: 4 LIHTLADHGDDVNCCAFS--FSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCC 61
++ L H + V CAFS S+L + K + L+++ +T + L+ H + V C
Sbjct: 206 MMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMI--RKLEGHHHDVVACD 263
Query: 62 FSPSGHILASCSTDGTTVLWNTENGQMLAVMEQ--PSGSP----------VRVCQFSPDS 109
FSP G +LA+ S D +W+ NG +L P +P VR FS D
Sbjct: 264 FSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDG 323
Query: 110 TCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVW 166
+AS A D V W + + +G CAFS +GS G+ G + W
Sbjct: 324 LHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSVYFW 378
Score = 60.5 bits (145), Expect = 3e-09
Identities = 62/225 (27%), Positives = 95/225 (42%), Gaps = 35/225 (15%)
Query: 104 QFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFF-VTGSSCGD 162
+F D LA+G +G + +W+ + KL + F+P+GS V+ S
Sbjct: 135 RFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKT 194
Query: 163 LTVWD--DKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVS 220
L VWD D + + H + C FS P S L S G V +W +
Sbjct: 195 LRVWDLKDDGNMMKVLRGHQNWVYSCAFS--PDSS--------MLCSVGASKAVFLWNMD 244
Query: 221 -FTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENIL----H 275
+T I L GH V+AC FS DG +L + S D V ++D + +IL H
Sbjct: 245 KYTMI--------RKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGH 296
Query: 276 TLTQHT---------RYVTTCAFAPNTLLLATGSMDKTVNIWQFD 311
T R+V + +F+ + L +A+ + DK V W+ D
Sbjct: 297 LFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRID 341
Score = 53.5 bits (127), Expect = 4e-07
Identities = 61/225 (27%), Positives = 92/225 (40%), Gaps = 26/225 (11%)
Query: 101 RVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSC 160
R + P S CL + GT + N+ S +L R S DG P C
Sbjct: 56 RTVKLVPWSQCLQNFLLHGTKNVTNSSSLRLPRQNS--DGGQKN---KPREHII----DC 106
Query: 161 GDLTVWDDKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVS 220
GD+ VW EK C + G+ L LA+ + ++KIW V
Sbjct: 107 GDI-VWSLAFGSSVPEKQS----RCVNIEWHRFRFGQDQLL---LATGLNNGRIKIWDV- 157
Query: 221 FTHILGFELKYKSTLSGHCAPVLACAFSHDGQM-LVSGSVDKSVIVYDTNTE-NILHTLT 278
+ K L H V F+ DG + LVS S DK++ V+D + N++ L
Sbjct: 158 ------YTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLR 211
Query: 279 QHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFDLETLCQARRTEH 323
H +V +CAF+P++ +L + K V +W D T+ + H
Sbjct: 212 GHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHH 256
>gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo
sapiens]
Length = 275
Score = 78.6 bits (192), Expect = 1e-14
Identities = 68/225 (30%), Positives = 96/225 (42%), Gaps = 22/225 (9%)
Query: 53 HTYAVHCCCFSPSGH-ILASCSTDGTTVLWNT-ENGQMLAVMEQPSGSPVRVCQFSPDST 110
HT V F+P G IL S S D T +W+ ++G M+ V+ V C FSPDS+
Sbjct: 23 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNW-VYSCAFSPDSS 81
Query: 111 CLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM 170
L S A V LWN Y + R + AC FSP+G+ T S + +WD
Sbjct: 82 MLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHN 141
Query: 171 RCLHSEKAHDLGITCCDFSS-------QPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTH 223
+ E H F+ + VS GL +AS D V+ W +
Sbjct: 142 GDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGL---HVASLADDKMVRFWRID--- 195
Query: 224 ILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDT 268
+ ++ +G C CAFS DG +L +G+ D SV + T
Sbjct: 196 -EDYPVQVAPLSNGLC-----CAFSTDGSVLAAGTHDGSVYFWAT 234
Score = 63.9 bits (154), Expect = 3e-10
Identities = 51/177 (28%), Positives = 77/177 (43%), Gaps = 18/177 (10%)
Query: 4 LIHTLADHGDDVNCCAFS--FSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCC 61
++ L H + V CAFS S+L + K + L+++ +T + L+ H + V C
Sbjct: 60 MMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMI--RKLEGHHHDVVACD 117
Query: 62 FSPSGHILASCSTDGTTVLWNTENGQMLAVMEQ--PSGSP----------VRVCQFSPDS 109
FSP G +LA+ S D +W+ NG +L P +P VR FS D
Sbjct: 118 FSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDG 177
Query: 110 TCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVW 166
+AS A D V W + + +G CAFS +GS G+ G + W
Sbjct: 178 LHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSVYFW 232
Score = 55.5 bits (132), Expect = 1e-07
Identities = 34/104 (32%), Positives = 49/104 (47%), Gaps = 6/104 (5%)
Query: 205 LASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVI 264
L S +D +++W L + L GH V +CAFS D ML S K+V
Sbjct: 40 LVSASRDKTLRVWD------LKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVF 93
Query: 265 VYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
+++ + ++ L H V C F+P+ LLAT S D V IW
Sbjct: 94 LWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIW 137
Score = 50.8 bits (120), Expect = 3e-06
Identities = 53/182 (29%), Positives = 78/182 (42%), Gaps = 35/182 (19%)
Query: 147 FSPNGSFF-VTGSSCGDLTVWD--DKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFF 203
F+P+GS V+ S L VWD D + + H + C FS P S
Sbjct: 32 FAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFS--PDSS-------- 81
Query: 204 RLASCGQDCQVKIWIVS-FTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKS 262
L S G V +W + +T I L GH V+AC FS DG +L + S D
Sbjct: 82 MLCSVGASKAVFLWNMDKYTMI--------RKLEGHHHDVVACDFSPDGALLATASYDTR 133
Query: 263 VIVYDTNTENIL----HTLTQHT---------RYVTTCAFAPNTLLLATGSMDKTVNIWQ 309
V ++D + +IL H T R+V + +F+ + L +A+ + DK V W+
Sbjct: 134 VYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWR 193
Query: 310 FD 311
D
Sbjct: 194 ID 195
Score = 49.3 bits (116), Expect = 8e-06
Identities = 29/91 (31%), Positives = 47/91 (51%), Gaps = 2/91 (2%)
Query: 235 LSGHCAPVLACAFSHDGQM-LVSGSVDKSVIVYDTNTE-NILHTLTQHTRYVTTCAFAPN 292
L H V F+ DG + LVS S DK++ V+D + N++ L H +V +CAF+P+
Sbjct: 20 LVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPD 79
Query: 293 TLLLATGSMDKTVNIWQFDLETLCQARRTEH 323
+ +L + K V +W D T+ + H
Sbjct: 80 SSMLCSVGASKAVFLWNMDKYTMIRKLEGHH 110
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 78.2 bits (191), Expect = 2e-14
Identities = 49/159 (30%), Positives = 82/159 (51%), Gaps = 9/159 (5%)
Query: 3 KLIHTLADHGDDVNCCAFSF----SLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVH 58
K++ TL H N C+ F +A+ S D I+L+ +R + + H+ AV
Sbjct: 96 KILRTLMGH--KANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFR--YRGHSQAVR 151
Query: 59 CCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAAD 118
C FSP G LAS + D T LW+ G+M++ +G PV V +F P+ LASG++D
Sbjct: 152 CLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTG-PVNVVEFHPNEYLLASGSSD 210
Query: 119 GTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTG 157
T+ W+ + +++ C + G + + F+P+G +G
Sbjct: 211 RTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSG 249
Score = 75.5 bits (184), Expect = 1e-13
Identities = 56/239 (23%), Positives = 102/239 (42%), Gaps = 19/239 (7%)
Query: 65 SGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLW 124
SG +LA+ D LW+ + + + SPV + + + +G+ G++ +W
Sbjct: 32 SGRLLATGGDDCRVNLWSINKPNCIMSLTGHT-SPVESVRLNTPEELIVAGSQSGSIRVW 90
Query: 125 NAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMR-CLHSEKAHDLGI 183
+ ++ K+ R ++ + F P G F +GS ++ +WD + + C+ + H +
Sbjct: 91 DLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAV 150
Query: 184 TCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVL 243
C FS DG+ LAS D VK+W ++ K S GH PV
Sbjct: 151 RCLRFS----PDGKW------LASAADDHTVKLWDLTAG-------KMMSEFPGHTGPVN 193
Query: 244 ACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMD 302
F + +L SGS D+++ +D ++ + V + F P+ L +G D
Sbjct: 194 VVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD 252
Score = 71.2 bits (173), Expect = 2e-12
Identities = 55/201 (27%), Positives = 82/201 (40%), Gaps = 18/201 (8%)
Query: 112 LASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD-DKM 170
LA+G D V LW+ + + + + V GS G + VWD +
Sbjct: 36 LATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAA 95
Query: 171 RCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELK 230
+ L + H I DF GE +AS QD +K+W + G +
Sbjct: 96 KILRTLMGHKANICSLDFHPY----GEF------VASGSQDTNIKLWDIRRK---GCVFR 142
Query: 231 YKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFA 290
Y+ GH V FS DG+ L S + D +V ++D ++ HT V F
Sbjct: 143 YR----GHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFH 198
Query: 291 PNTLLLATGSMDKTVNIWQFD 311
PN LLA+GS D+T+ W +
Sbjct: 199 PNEYLLASGSSDRTIRFWDLE 219
Score = 50.1 bits (118), Expect = 4e-06
Identities = 34/106 (32%), Positives = 45/106 (42%), Gaps = 1/106 (0%)
Query: 62 FSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTV 121
F P G +AS S D LW+ + + VR +FSPD LAS A D TV
Sbjct: 113 FHPYGEFVASGSQDTNIKLWDIRR-KGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTV 171
Query: 122 VLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD 167
LW+ + K+ G + F PN +GSS + WD
Sbjct: 172 KLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWD 217
Score = 33.5 bits (75), Expect = 0.43
Identities = 16/61 (26%), Positives = 29/61 (47%)
Query: 251 GQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQF 310
G++L +G D V ++ N N + +LT HT V + L+ GS ++ +W
Sbjct: 33 GRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDL 92
Query: 311 D 311
+
Sbjct: 93 E 93
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 75.9 bits (185), Expect = 8e-14
Identities = 77/307 (25%), Positives = 124/307 (40%), Gaps = 46/307 (14%)
Query: 44 ELPHSP---LKFHTYAVHCCCFSPSGHILASCSTDGTTVLWN----TENGQMLAVMEQ-- 94
E+P S L+ H V C ++P +LAS S D T +WN + G V+
Sbjct: 168 EIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCI 227
Query: 95 -------PSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAF 147
PS V ++ + T LA+G+ DG +W G K G + A +
Sbjct: 228 REGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHK-GPIFALKW 286
Query: 148 SPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHDLGITCCDFSSQPVSDGE-QGLQFFRLA 206
+ G++ ++ +WD H+ +A F S P D + Q F A
Sbjct: 287 NRKGNYILSAGVDKTTIIWD-----AHTGEAKQQ----FPFHSAPALDVDWQNNTTF--A 335
Query: 207 SCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVY 266
SC D + + LG + K T GH V A + G +L S S D ++ ++
Sbjct: 336 SCSTDMCIHVCR------LGCDRPVK-TFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 388
Query: 267 DTNTENILHTLTQHTRYVTTCAFAP---------NTLLLATGSMDKTVNIWQFDLETLCQ 317
E +H L H + + T ++P + ++LA+ S D TV +W + +C
Sbjct: 389 SMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIE-RGVCT 447
Query: 318 ARRTEHQ 324
T+HQ
Sbjct: 448 HTLTKHQ 454
Score = 65.9 bits (159), Expect = 8e-11
Identities = 53/174 (30%), Positives = 80/174 (45%), Gaps = 15/174 (8%)
Query: 5 IHTLADHGDDVNCCAFSFS--LLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCF 62
+ T H ++VN + S LLA+CS D T++++S++ E+ L+ H ++ +
Sbjct: 354 VKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ--EVCIHDLQAHNKEIYTIKW 411
Query: 63 SPSGH---------ILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLA 113
SP+G +LAS S D T LW+ E G + + PV FSPD LA
Sbjct: 412 SPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQ-EPVYSVAFSPDGKYLA 470
Query: 114 SGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD 167
SG+ D V +WN QS L G C ++ G +S G + V D
Sbjct: 471 SGSFDKCVHIWNTQSGNLVHSYRGTGGIFEVC-WNARGDKVGASASDGSVCVLD 523
Score = 54.3 bits (129), Expect = 2e-07
Identities = 42/154 (27%), Positives = 69/154 (44%), Gaps = 18/154 (11%)
Query: 26 ATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVLWN--- 82
A+CS D I + L + P + HT V+ + PSG +LASCS D T +W+
Sbjct: 335 ASCSTDMCIHVCRLG--CDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ 392
Query: 83 --------TENGQMLAVMEQPSGSPVRVCQFSPDST-CLASGAADGTVVLWNAQSYKLYR 133
N ++ + P+G +P+S LAS + D TV LW+ +
Sbjct: 393 EVCIHDLQAHNKEIYTIKWSPTGPATS----NPNSNIMLASASFDSTVRLWDIERGVCTH 448
Query: 134 CGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD 167
+ + + AFSP+G + +GS + +W+
Sbjct: 449 TLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWN 482
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.133 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,689,852
Number of Sequences: 37866
Number of extensions: 838297
Number of successful extensions: 5146
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 223
Number of HSP's successfully gapped in prelim test: 121
Number of HSP's that attempted gapping in prelim test: 2196
Number of HSP's gapped (non-prelim): 1639
length of query: 476
length of database: 18,247,518
effective HSP length: 106
effective length of query: 370
effective length of database: 14,233,722
effective search space: 5266477140
effective search space used: 5266477140
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.