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Search of human proteins with 189491647
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|189491647 fibulin 7 isoform 2 [Homo sapiens]
(393 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|189491647 fibulin 7 isoform 2 [Homo sapiens] 832 0.0
gi|189491645 fibulin 7 isoform 1 [Homo sapiens] 810 0.0
gi|34734062 fibulin 1 isoform C precursor [Homo sapiens] 157 2e-38
gi|19743803 fibulin 5 precursor [Homo sapiens] 138 8e-33
gi|51873055 fibulin 2 isoform b precursor [Homo sapiens] 137 2e-32
gi|51873053 fibulin 2 isoform a precursor [Homo sapiens] 137 2e-32
gi|34734066 fibulin 1 isoform D [Homo sapiens] 119 5e-27
gi|190343004 EGF-containing fibulin-like extracellular matrix pr... 118 1e-26
gi|86788132 EGF-containing fibulin-like extracellular matrix pro... 115 9e-26
gi|86788015 EGF-containing fibulin-like extracellular matrix pro... 115 9e-26
gi|9665262 EGF-containing fibulin-like extracellular matrix prot... 115 9e-26
gi|34734064 fibulin 1 isoform B precursor [Homo sapiens] 103 2e-22
gi|122937283 6720455I24Rik homolog [Homo sapiens] 103 3e-22
gi|118572606 hemicentin 1 [Homo sapiens] 100 2e-21
gi|110347437 latent transforming growth factor beta binding prot... 100 3e-21
gi|110347412 latent transforming growth factor beta binding prot... 100 3e-21
gi|110347431 latent transforming growth factor beta binding prot... 100 3e-21
gi|148833508 notch1 preproprotein [Homo sapiens] 99 7e-21
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 98 1e-20
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 98 1e-20
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 98 1e-20
gi|34734068 fibulin 1 isoform A precursor [Homo sapiens] 98 1e-20
gi|46249414 latent transforming growth factor beta binding prote... 97 2e-20
gi|46249412 latent transforming growth factor beta binding prote... 97 2e-20
gi|24041035 notch 2 preproprotein [Homo sapiens] 96 4e-20
gi|56237021 fibrillin 3 precursor [Homo sapiens] 96 7e-20
gi|24430141 fibrillin 1 precursor [Homo sapiens] 95 1e-19
gi|66346695 fibrillin 2 precursor [Homo sapiens] 95 1e-19
gi|55770876 notch4 preproprotein [Homo sapiens] 94 2e-19
gi|148886654 polydom [Homo sapiens] 93 4e-19
>gi|189491647 fibulin 7 isoform 2 [Homo sapiens]
Length = 393
Score = 832 bits (2148), Expect = 0.0
Identities = 393/393 (100%), Positives = 393/393 (100%)
Query: 1 MVPSSPRALFLLLLILACPEPRASQNCLSKQQLLSAIRQLQQLLKGQETRFAEGIRHMKS 60
MVPSSPRALFLLLLILACPEPRASQNCLSKQQLLSAIRQLQQLLKGQETRFAEGIRHMKS
Sbjct: 1 MVPSSPRALFLLLLILACPEPRASQNCLSKQQLLSAIRQLQQLLKGQETRFAEGIRHMKS 60
Query: 61 RLAALQNSVGRVGPDALPVSCPALNTPADGRKFGSKYLVDHEVHFTCNPGFRLVGPSSVV 120
RLAALQNSVGRVGPDALPVSCPALNTPADGRKFGSKYLVDHEVHFTCNPGFRLVGPSSVV
Sbjct: 61 RLAALQNSVGRVGPDALPVSCPALNTPADGRKFGSKYLVDHEVHFTCNPGFRLVGPSSVV 120
Query: 121 CLPNGTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVN 180
CLPNGTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVN
Sbjct: 121 CLPNGTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVN 180
Query: 181 ECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTT 240
ECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTT
Sbjct: 181 ECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTT 240
Query: 241 CINTGGSFQCVSPECPEGSGNVSYVKTSPFQCERNPCPMDSRPCRHLPKTISFHYLSLPS 300
CINTGGSFQCVSPECPEGSGNVSYVKTSPFQCERNPCPMDSRPCRHLPKTISFHYLSLPS
Sbjct: 241 CINTGGSFQCVSPECPEGSGNVSYVKTSPFQCERNPCPMDSRPCRHLPKTISFHYLSLPS 300
Query: 301 NLKTPITLFRMATASAPGRAGPNSLRFGIVGGNSRGHFVMQRSDRQTGDLILVQNLEGPQ 360
NLKTPITLFRMATASAPGRAGPNSLRFGIVGGNSRGHFVMQRSDRQTGDLILVQNLEGPQ
Sbjct: 301 NLKTPITLFRMATASAPGRAGPNSLRFGIVGGNSRGHFVMQRSDRQTGDLILVQNLEGPQ 360
Query: 361 TLEVDVDMSEYLDRSFQANHVSKVTIFVSPYDF 393
TLEVDVDMSEYLDRSFQANHVSKVTIFVSPYDF
Sbjct: 361 TLEVDVDMSEYLDRSFQANHVSKVTIFVSPYDF 393
>gi|189491645 fibulin 7 isoform 1 [Homo sapiens]
Length = 439
Score = 810 bits (2091), Expect = 0.0
Identities = 393/439 (89%), Positives = 393/439 (89%), Gaps = 46/439 (10%)
Query: 1 MVPSSPRALFLLLLILACPEPRASQNCLSKQQLLSAIRQLQQLLKGQETRFAEGIRHMKS 60
MVPSSPRALFLLLLILACPEPRASQNCLSKQQLLSAIRQLQQLLKGQETRFAEGIRHMKS
Sbjct: 1 MVPSSPRALFLLLLILACPEPRASQNCLSKQQLLSAIRQLQQLLKGQETRFAEGIRHMKS 60
Query: 61 RLAALQNSVGRVGPDALPVSCPALNTPADGRKFGSKYLVDHEVHFTCNPGFRLVGPSSVV 120
RLAALQNSVGRVGPDALPVSCPALNTPADGRKFGSKYLVDHEVHFTCNPGFRLVGPSSVV
Sbjct: 61 RLAALQNSVGRVGPDALPVSCPALNTPADGRKFGSKYLVDHEVHFTCNPGFRLVGPSSVV 120
Query: 121 CLPNGTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQT--- 177
CLPNGTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQT
Sbjct: 121 CLPNGTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTAAP 180
Query: 178 -------------------------------------------DVNECELYGQEGRPRLC 194
DVNECELYGQEGRPRLC
Sbjct: 181 EGSVAGDSAFSRAPRCAQVERAQHCSCEAGFHLSGAAGDSVCQDVNECELYGQEGRPRLC 240
Query: 195 MHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPE 254
MHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPE
Sbjct: 241 MHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPE 300
Query: 255 CPEGSGNVSYVKTSPFQCERNPCPMDSRPCRHLPKTISFHYLSLPSNLKTPITLFRMATA 314
CPEGSGNVSYVKTSPFQCERNPCPMDSRPCRHLPKTISFHYLSLPSNLKTPITLFRMATA
Sbjct: 301 CPEGSGNVSYVKTSPFQCERNPCPMDSRPCRHLPKTISFHYLSLPSNLKTPITLFRMATA 360
Query: 315 SAPGRAGPNSLRFGIVGGNSRGHFVMQRSDRQTGDLILVQNLEGPQTLEVDVDMSEYLDR 374
SAPGRAGPNSLRFGIVGGNSRGHFVMQRSDRQTGDLILVQNLEGPQTLEVDVDMSEYLDR
Sbjct: 361 SAPGRAGPNSLRFGIVGGNSRGHFVMQRSDRQTGDLILVQNLEGPQTLEVDVDMSEYLDR 420
Query: 375 SFQANHVSKVTIFVSPYDF 393
SFQANHVSKVTIFVSPYDF
Sbjct: 421 SFQANHVSKVTIFVSPYDF 439
>gi|34734062 fibulin 1 isoform C precursor [Homo sapiens]
Length = 683
Score = 157 bits (397), Expect = 2e-38
Identities = 89/258 (34%), Positives = 140/258 (54%), Gaps = 18/258 (6%)
Query: 134 CRGISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRL 193
C I+ECSS PC C Y+C C G + D++EC L +
Sbjct: 439 CEDINECSSSPCSQ--ECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECAL---PTGGHI 493
Query: 194 CMHACVNTPGSYRCTCPG-GYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVS 252
C + C+N PGS++C+CP GYR +G++C+D+DECV C TC N G F+C++
Sbjct: 494 CSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLA 553
Query: 253 PECPEGSGNVSYVKTSPFQCERNPCPMDSRPCRHLPKTISFHYLSLPSNLKTPITLFRMA 312
ECPE +Y +++ +CER PC ++R C LP I++++LS P+N++ P +FRM
Sbjct: 554 FECPE-----NYRRSAATRCERLPC-HENRECSKLPLRITYYHLSFPTNIQAPAVVFRMG 607
Query: 313 TASA-PGRAGPNSLRFGIVGGNSRGHFVMQRSDRQTGDLILVQNLEGPQTLEVDVDMSEY 371
+SA PG +S++ I GGN G F ++ +G + L + + P+ L + V M +
Sbjct: 608 PSSAVPG----DSMQLAITGGNEEGFFTTRKVSPHSGVVALTKPVPEPRDLLLTVKM-DL 662
Query: 372 LDRSFQANHVSKVTIFVS 389
++ V+K+ IFVS
Sbjct: 663 SRHGTVSSFVAKLFIFVS 680
Score = 69.7 bits (169), Expect = 4e-12
Identities = 51/170 (30%), Positives = 69/170 (40%), Gaps = 21/170 (12%)
Query: 130 EQPHCRGISECSS--QPCQNGGTCVEGVNQYRCI----CPPGRTGNRCQHQAQTDVNECE 183
E C+ I EC S C C + +RC C G + + D+NEC
Sbjct: 256 EDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCI--DINECL 313
Query: 184 LYGQEGRPRLCMHACVNTPGSYRC-----TCPGGYRTLADGKSCEDVDECVGLQPVCPQG 238
P H C+NT GSY C C GY +G C DVDEC C +G
Sbjct: 314 SISA---PCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKG 370
Query: 239 TTCINTGGSFQCVSPECPEG--SGNVSYVKTSPFQCERNPCPMDSRPCRH 286
C+N+ GSF+C EC G +S + +C+R P + C +
Sbjct: 371 HRCVNSPGSFRC---ECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCEN 417
Score = 60.8 bits (146), Expect = 2e-09
Identities = 27/57 (47%), Positives = 35/57 (61%)
Query: 194 CMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQC 250
C C +T C+C GY+ L+DG SCEDV+EC+ C G +CINT GSF+C
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRC 242
Score = 57.8 bits (138), Expect = 2e-08
Identities = 51/161 (31%), Positives = 70/161 (43%), Gaps = 31/161 (19%)
Query: 134 CRGISECSSQPCQNGGTCVEGVNQYRCICPPG----RTGNRCQHQAQTDVNECELYGQEG 189
CRG C Q C++ G ++ C C G G C+ DVNEC
Sbjct: 180 CRGGGPCKQQ-CRDTG------DEVVCSCFVGYQLLSDGVSCE-----DVNECITGSHSC 227
Query: 190 RPRLCMHACVNTPGSYRC----TCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTG 245
R +C+NT GS+RC +C GY L + SC+D+DEC C C NT
Sbjct: 228 R---LGESCINTVGSFRCQRDSSCGTGYE-LTEDNSCKDIDECESGIHNCLPDFICQNTL 283
Query: 246 GSFQC-VSPECPEGSGNVSYVKTSPFQC-ERNPCPMDSRPC 284
GSF+C +C G +++ + C + N C S PC
Sbjct: 284 GSFRCRPKLQCKSG-----FIQDALGNCIDINECLSISAPC 319
>gi|19743803 fibulin 5 precursor [Homo sapiens]
Length = 448
Score = 138 bits (348), Expect = 8e-33
Identities = 89/287 (31%), Positives = 140/287 (48%), Gaps = 32/287 (11%)
Query: 115 GPSSVVCLPNGTWTGEQPHCRGISECSSQ-PCQNGGTCVEGVNQYRCICPPG----RTGN 169
G S C P T + C+ ++EC+++ PC TCV + C C PG G
Sbjct: 186 GSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQ--TCVNTYGSFICRCDPGYELEEDGV 243
Query: 170 RCQHQAQTDVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECV 229
C +D++EC LC H CVN PG+Y C+CP GY L D +SC+D++EC
Sbjct: 244 HC-----SDMDECSF-----SEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECE 293
Query: 230 GLQPVCPQGTTCINTGGSFQCVSP-ECPEGSGNVSYVKTSPFQCERNPCPMDSRPCRHLP 288
C TC N G F+C+ P C E Y++ S +C CP ++ CR P
Sbjct: 294 HRNHTCNLQQTCYNLQGGFKCIDPIRCEE-----PYLRISDNRC---MCPAENPGCRDQP 345
Query: 289 KTISFHYLSLPSNLKTPITLFRM-ATASAPGRAGPNSLRFGIVGGNSRGHFVMQRSDRQT 347
TI + + + S P +F+M AT PG F I GN F M+++ +
Sbjct: 346 FTILYRDMDVVSGRSVPADIFQMQATTRYPGA----YYIFQIKSGNEGREFYMRQTGPIS 401
Query: 348 GDLILVQNLEGPQTLEVDVDM-SEYLDRSFQANHVSKVTIFVSPYDF 393
L++ + ++GP+ +++D++M + +F+ + V ++ I+VS Y F
Sbjct: 402 ATLVMTRPIKGPREIQLDLEMITVNTVINFRGSSVIRLRIYVSQYPF 448
Score = 77.8 bits (190), Expect = 2e-14
Identities = 47/125 (37%), Positives = 58/125 (46%), Gaps = 19/125 (15%)
Query: 130 EQPHCRGISECS--SQPCQNGGTCVEGVNQYRCICPPGR--TGNRCQHQAQTDVNECELY 185
E C + EC+ S C C+ Y C C G +C D++EC Y
Sbjct: 121 ESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQC-----LDIDECR-Y 174
Query: 186 GQEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTG 245
G C C N PGSY CTC G+ DG+SC+DV+EC P C Q TC+NT
Sbjct: 175 GY------CQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENP-CVQ--TCVNTY 225
Query: 246 GSFQC 250
GSF C
Sbjct: 226 GSFIC 230
Score = 44.7 bits (104), Expect = 1e-04
Identities = 22/86 (25%), Positives = 36/86 (41%), Gaps = 3/86 (3%)
Query: 198 CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPE 257
C+ +PG+ + C G+ C D+DEC + C C+N G + C+ P
Sbjct: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
Query: 258 GSGNVSYVKTSPFQCERNPCPMDSRP 283
G S ++P+ P P + P
Sbjct: 76 YRGPYSNPYSTPYS---GPYPAAAPP 98
>gi|51873055 fibulin 2 isoform b precursor [Homo sapiens]
Length = 1184
Score = 137 bits (345), Expect = 2e-32
Identities = 86/263 (32%), Positives = 132/263 (50%), Gaps = 26/263 (9%)
Query: 134 CRGISECSSQPCQNGGTCVEGVNQYRCICPPG----RTGNRCQHQAQTDVNECELYGQEG 189
C ++EC +Q C C Y+C C G G+ C TD++EC +G
Sbjct: 941 CEDVNECEAQRCSQ--ECANIYGSYQCYCRQGYQLAEDGHTC-----TDIDECA----QG 989
Query: 190 RPRLCMHACVNTPGSYRCTCPG-GYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSF 248
LC C+N PGSY+C CP GY A+G+SC+DVDEC C + TC N GSF
Sbjct: 990 AGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSF 1049
Query: 249 QCVSPECPEGSGNVSYVKTSPFQCERNPCPMDSRPCRHLPKTISFHYLSLPSNLKTPITL 308
+C+ ECP +YV+ S +CER C D C++ P I+ + L+ + L P +
Sbjct: 1050 RCLRFECPP-----NYVQVSKTKCERTTC-HDFLECQNSPARITHYQLNFQTGLLVPAHI 1103
Query: 309 FRMATASAPGRAGPNSLRFGIVGGNSRGHFVMQRSDRQTGDLILVQNLEGPQTLEVDVDM 368
FR+ AP G +++ I+ GN G+F +R + TG + L + + P+ +DV+M
Sbjct: 1104 FRI--GPAPAFTG-DTIALNIIKGNEEGYFGTRRLNAYTGVVYLQRAVLEPRDFALDVEM 1160
Query: 369 SEYLDRSFQANHVSKVTIFVSPY 391
+ S ++K+ IF + +
Sbjct: 1161 KLWRQGSV-TTFLAKMHIFFTTF 1182
Score = 69.7 bits (169), Expect = 4e-12
Identities = 55/200 (27%), Positives = 80/200 (40%), Gaps = 36/200 (18%)
Query: 64 ALQNSVGRVGPDALPVSCPALNTPADGRKFGSKYLVDHEVHFTCNPGFRLVGPSSVV-CL 122
AL++ +V + +P+ P NT D C VG S++ C
Sbjct: 660 ALKSEFSQVASNTIPLPLPQPNTCKDNGP--------------CKQVCSTVGGSAICSCF 705
Query: 123 PNGTWTGEQPHCRGISECSSQ--PCQNGGTCVEGVNQYRCI----CPPGRT--GNRCQHQ 174
P + C I+EC + C G CV + + C C PG C+
Sbjct: 706 PGYAIMADGVSCEDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECE-- 763
Query: 175 AQTDVNECELYGQEGRPRLCMHACVNTPGSYRCT----CPGGYRTLADGKSCEDVDECVG 230
DV+EC + +P C NT GS+ C C G+ +G +C D++EC
Sbjct: 764 ---DVDECAMGTHTCQPGFL---CQNTKGSFYCQARQRCMDGFLQDPEG-NCVDINECTS 816
Query: 231 LQPVCPQGTTCINTGGSFQC 250
L C G +CINT GS+ C
Sbjct: 817 LSEPCRPGFSCINTVGSYTC 836
Score = 65.9 bits (159), Expect = 6e-11
Identities = 48/161 (29%), Positives = 63/161 (39%), Gaps = 43/161 (26%)
Query: 122 LPNGTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPPGRT----GNRCQ---HQ 174
LPN +Q C + + CQ+ C+ V Y C C PG + G C+ H
Sbjct: 596 LPNSLPGDDQDECLLLP---GELCQH--LCINTVGSYHCACFPGFSLQDDGRTCRPEGHP 650
Query: 175 AQTDV-------------------------NECELYGQEGRPRLCMHACVNTPGSYRCTC 209
Q + N C+ G C C GS C+C
Sbjct: 651 PQPEAPQEPALKSEFSQVASNTIPLPLPQPNTCKDNGP------CKQVCSTVGGSAICSC 704
Query: 210 PGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQC 250
GY +ADG SCED++ECV C +G C+NT GSF C
Sbjct: 705 FPGYAIMADGVSCEDINECVTDLHTCSRGEHCVNTLGSFHC 745
>gi|51873053 fibulin 2 isoform a precursor [Homo sapiens]
Length = 1231
Score = 137 bits (345), Expect = 2e-32
Identities = 86/263 (32%), Positives = 132/263 (50%), Gaps = 26/263 (9%)
Query: 134 CRGISECSSQPCQNGGTCVEGVNQYRCICPPG----RTGNRCQHQAQTDVNECELYGQEG 189
C ++EC +Q C C Y+C C G G+ C TD++EC +G
Sbjct: 988 CEDVNECEAQRCSQ--ECANIYGSYQCYCRQGYQLAEDGHTC-----TDIDECA----QG 1036
Query: 190 RPRLCMHACVNTPGSYRCTCPG-GYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSF 248
LC C+N PGSY+C CP GY A+G+SC+DVDEC C + TC N GSF
Sbjct: 1037 AGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSF 1096
Query: 249 QCVSPECPEGSGNVSYVKTSPFQCERNPCPMDSRPCRHLPKTISFHYLSLPSNLKTPITL 308
+C+ ECP +YV+ S +CER C D C++ P I+ + L+ + L P +
Sbjct: 1097 RCLRFECPP-----NYVQVSKTKCERTTC-HDFLECQNSPARITHYQLNFQTGLLVPAHI 1150
Query: 309 FRMATASAPGRAGPNSLRFGIVGGNSRGHFVMQRSDRQTGDLILVQNLEGPQTLEVDVDM 368
FR+ AP G +++ I+ GN G+F +R + TG + L + + P+ +DV+M
Sbjct: 1151 FRI--GPAPAFTG-DTIALNIIKGNEEGYFGTRRLNAYTGVVYLQRAVLEPRDFALDVEM 1207
Query: 369 SEYLDRSFQANHVSKVTIFVSPY 391
+ S ++K+ IF + +
Sbjct: 1208 KLWRQGSV-TTFLAKMHIFFTTF 1229
Score = 66.6 bits (161), Expect = 4e-11
Identities = 61/212 (28%), Positives = 82/212 (38%), Gaps = 55/212 (25%)
Query: 122 LPNGTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPPGRT----GNRCQ---HQ 174
LPN +Q C + + CQ+ C+ V Y C C PG + G C+ H
Sbjct: 596 LPNSLPGDDQDECLLLP---GELCQH--LCINTVGSYHCACFPGFSLQDDGRTCRPEGHP 650
Query: 175 AQTDV-------------------------NECELYGQEGRPRLCMHACVNTPGSYRCTC 209
Q + N C+ G C C GS C+C
Sbjct: 651 PQPEAPQEPALKSEFSQVASNTIPLPLPQPNTCKDNGP------CKQVCSTVGGSAICSC 704
Query: 210 PGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPE--CPEGSGNVSYVKT 267
GY +ADG SCED DEC+ C + C+NT GSF CV+ C +G Y+
Sbjct: 705 FPGYAIMADGVSCEDQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADG-----YILN 759
Query: 268 SPFQC-ERNPCPMDSRPC---RHLPKTI-SFH 294
+ +C + N C D C H T+ SFH
Sbjct: 760 AHRKCVDINECVTDLHTCSRGEHCVNTLGSFH 791
Score = 61.2 bits (147), Expect = 2e-09
Identities = 50/169 (29%), Positives = 68/169 (40%), Gaps = 38/169 (22%)
Query: 94 GSKYLVDHEVHFTCNPGFRLVGPSSVVCLPNGTWTGEQPHCRGISECSSQ--PCQNGGTC 151
GS Y V+H V C G+ L C I+EC + C G C
Sbjct: 741 GSFYCVNHTV--LCADGYIL---------------NAHRKCVDINECVTDLHTCSRGEHC 783
Query: 152 VEGVNQYRCI----CPPGRT--GNRCQHQAQTDVNECELYGQEGRPRLCMHACVNTPGSY 205
V + + C C PG C+ DV+EC + +P C NT GS+
Sbjct: 784 VNTLGSFHCYKALTCEPGYALKDGECE-----DVDECAMGTHTCQPGFL---CQNTKGSF 835
Query: 206 RCT----CPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQC 250
C C G+ +G +C D++EC L C G +CINT GS+ C
Sbjct: 836 YCQARQRCMDGFLQDPEG-NCVDINECTSLSEPCRPGFSCINTVGSYTC 883
>gi|34734066 fibulin 1 isoform D [Homo sapiens]
Length = 703
Score = 119 bits (298), Expect = 5e-27
Identities = 82/270 (30%), Positives = 124/270 (45%), Gaps = 15/270 (5%)
Query: 134 CRGISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRL 193
C I+ECSS PC C Y+C C G + D++EC L +
Sbjct: 439 CEDINECSSSPCSQ--ECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECAL---PTGGHI 493
Query: 194 CMHACVNTPGSYRCTCPG-GYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVS 252
C + C+N PGS++C+CP GYR +G++C+D+DECV C TC N G F+C++
Sbjct: 494 CSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLA 553
Query: 253 PECPE----GSGNVSYVKTSPFQCERNPCPMDSRPCRHLPKTISFHYLSLPS--NLKTPI 306
ECPE + + KT +C ++ P D TIS +SLP+ P
Sbjct: 554 FECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDPVHTISHTVISLPTFREFTRPE 613
Query: 307 TLFRMATASAPGRAGPNSLRFGIVGGNSRGHF--VMQRSDRQT-GDLILVQNLEGPQTLE 363
+ + + P A ++ F I GN R F + + D T G + V+ + GP
Sbjct: 614 EIIFLRAITPPHPASQANIIFDITEGNLRDSFDIIKRYMDGMTVGVVRQVRPIVGPFHAV 673
Query: 364 VDVDMSEYLDRSFQANHVSKVTIFVSPYDF 393
+ ++M+ + +V V IFVS Y F
Sbjct: 674 LKLEMNYVVGGVVSHRNVVNVHIFVSEYWF 703
Score = 69.7 bits (169), Expect = 4e-12
Identities = 51/170 (30%), Positives = 69/170 (40%), Gaps = 21/170 (12%)
Query: 130 EQPHCRGISECSS--QPCQNGGTCVEGVNQYRCI----CPPGRTGNRCQHQAQTDVNECE 183
E C+ I EC S C C + +RC C G + + D+NEC
Sbjct: 256 EDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCI--DINECL 313
Query: 184 LYGQEGRPRLCMHACVNTPGSYRC-----TCPGGYRTLADGKSCEDVDECVGLQPVCPQG 238
P H C+NT GSY C C GY +G C DVDEC C +G
Sbjct: 314 SISA---PCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKG 370
Query: 239 TTCINTGGSFQCVSPECPEG--SGNVSYVKTSPFQCERNPCPMDSRPCRH 286
C+N+ GSF+C EC G +S + +C+R P + C +
Sbjct: 371 HRCVNSPGSFRC---ECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCEN 417
Score = 60.8 bits (146), Expect = 2e-09
Identities = 27/57 (47%), Positives = 35/57 (61%)
Query: 194 CMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQC 250
C C +T C+C GY+ L+DG SCEDV+EC+ C G +CINT GSF+C
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRC 242
Score = 57.8 bits (138), Expect = 2e-08
Identities = 51/161 (31%), Positives = 70/161 (43%), Gaps = 31/161 (19%)
Query: 134 CRGISECSSQPCQNGGTCVEGVNQYRCICPPG----RTGNRCQHQAQTDVNECELYGQEG 189
CRG C Q C++ G ++ C C G G C+ DVNEC
Sbjct: 180 CRGGGPCKQQ-CRDTG------DEVVCSCFVGYQLLSDGVSCE-----DVNECITGSHSC 227
Query: 190 RPRLCMHACVNTPGSYRC----TCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTG 245
R +C+NT GS+RC +C GY L + SC+D+DEC C C NT
Sbjct: 228 R---LGESCINTVGSFRCQRDSSCGTGYE-LTEDNSCKDIDECESGIHNCLPDFICQNTL 283
Query: 246 GSFQC-VSPECPEGSGNVSYVKTSPFQC-ERNPCPMDSRPC 284
GSF+C +C G +++ + C + N C S PC
Sbjct: 284 GSFRCRPKLQCKSG-----FIQDALGNCIDINECLSISAPC 319
>gi|190343004 EGF-containing fibulin-like extracellular matrix
protein 2 [Homo sapiens]
Length = 443
Score = 118 bits (295), Expect = 1e-26
Identities = 92/326 (28%), Positives = 141/326 (43%), Gaps = 70/326 (21%)
Query: 106 TCNPGFRLVGPSSVVCLPNGTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPPG 165
TC G+R +GP C I EC + CQ+ CV +RC C PG
Sbjct: 150 TCPDGYRKIGPE----------------CVDIDECRYRYCQH--RCVNLPGSFRCQCEPG 191
Query: 166 -RTGNRCQHQAQTDVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCED 224
+ G +++ DVNEC++ G P C C N+ G++ C C GY DG SC D
Sbjct: 192 FQLGPN--NRSCVDVNECDM----GAP--CEQRCFNSYGTFLCRCHQGYELHRDGFSCSD 243
Query: 225 VDECVGLQPVCPQGTTCINTGGSFQCVSP---------------ECPEGSGNVSYVKT-- 267
+DEC +C C+N G F C P EC G+ S +T
Sbjct: 244 IDECSYSSYLCQY--RCVNEPGRFSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQTCV 301
Query: 268 ---SPFQC---------------ERNPCPMDSRPCRHLPKTISFHYLSLPSNLKTPITLF 309
++C R CP + CR P +I Y+++ S P +F
Sbjct: 302 NFHGGYRCVDTNRCVEPYIQVSENRCLCPASNPLCREQPSSIVHRYMTITSERSVPADVF 361
Query: 310 RM-ATASAPGRAGPNSLRFGIVGGNSRGHFVMQRSDRQTGDLILVQNLEGPQTLEVDVDM 368
++ AT+ PG F I GNS+G F +++ + + L+L + + GP+ +D++M
Sbjct: 362 QIQATSVYPGAYN----AFQIRAGNSQGDFYIRQINNVSAMLVLARPVTGPREYVLDLEM 417
Query: 369 SEYLD-RSFQANHVSKVTIFVSPYDF 393
S++A+ V ++T+FV Y F
Sbjct: 418 VTMNSLMSYRASSVLRLTVFVGAYTF 443
Score = 75.1 bits (183), Expect = 1e-13
Identities = 56/186 (30%), Positives = 75/186 (40%), Gaps = 40/186 (21%)
Query: 121 CLPNGTWTGEQPHCRGISECSSQP--CQNGGTCVEGVNQYRCI----------------- 161
C W + HCR ++EC + P C+ C+ Y C+
Sbjct: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPP 98
Query: 162 -CPPGRTGNRC-------QHQAQTDVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGY 213
PP + N C + DV+EC + RP C N PGSY+CTCP GY
Sbjct: 99 PVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRP---SQDCHNLPGSYQCTCPDGY 155
Query: 214 RTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQC-VSPECPEGSGNVSYVKTSPFQC 272
R + G C D+DEC C C+N GSF+C P G N S V + +C
Sbjct: 156 RKI--GPECVDIDEC--RYRYCQH--RCVNLPGSFRCQCEPGFQLGPNNRSCVDVN--EC 207
Query: 273 ERN-PC 277
+ PC
Sbjct: 208 DMGAPC 213
Score = 39.3 bits (90), Expect = 0.006
Identities = 27/87 (31%), Positives = 33/87 (37%), Gaps = 9/87 (10%)
Query: 202 PGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECP----- 256
P SY C GY D + C DV+EC+ + C CIN G + C+
Sbjct: 33 PDSYT-ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDL 91
Query: 257 EGSGNVSYVKTSPFQCERNPCPMDSRP 283
G G V P NPCP P
Sbjct: 92 HGEGPPPPV---PPAQHPNPCPPGYEP 115
>gi|86788132 EGF-containing fibulin-like extracellular matrix
protein 1 precursor [Homo sapiens]
Length = 493
Score = 115 bits (287), Expect = 9e-26
Identities = 91/320 (28%), Positives = 137/320 (42%), Gaps = 58/320 (18%)
Query: 113 LVGPSSVVCLPNGTWTGEQPHCRGISECSSQP-CQNGGTCVEGVNQYRCICPPGRTGNRC 171
L G + C P GEQ C I EC+ P C CV + C C PG
Sbjct: 193 LRGSFACQCPPGYQKRGEQ--CVDIDECTIPPYCHQ--RCVNTPGSFYCQCSPGFQ-LAA 247
Query: 172 QHQAQTDVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGL 231
+ D+NEC+ Q C C N GS+ C C GY +D +CED+DEC
Sbjct: 248 NNYTCVDINECDASNQ------CAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTS 301
Query: 232 QPVCPQGTTCINTGGSFQCVSP---------------------ECPEGSGNVSYVKTSPF 270
+C C+N G F C+ P EC E +Y F
Sbjct: 302 SYLCQY--QCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNY--HGGF 357
Query: 271 QC-ERNP--------------CPMDSRPCRHLPKTISFHYLSLPSNLKTPITLFRMATAS 315
+C RNP CP+ + CR LP++I + Y+S+ S+ P +F++ +
Sbjct: 358 RCYPRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATT 417
Query: 316 APGRAGPNSLR-FGIVGGNSRGHFVMQRSDRQTGDLILVQNLEGPQTLEVDVDMSEYLD- 373
N++ F I GN G F ++++ + L+LV++L GP+ VD++M
Sbjct: 418 IYA----NTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSI 473
Query: 374 RSFQANHVSKVTIFVSPYDF 393
+F+ + V ++TI V P+ F
Sbjct: 474 GTFRTSSVLRLTIIVGPFSF 493
Score = 35.4 bits (80), Expect = 0.090
Identities = 14/43 (32%), Positives = 21/43 (48%)
Query: 209 CPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCV 251
C GY + C+D+DEC + C G C+N G + C+
Sbjct: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL 71
>gi|86788015 EGF-containing fibulin-like extracellular matrix
protein 1 precursor [Homo sapiens]
Length = 493
Score = 115 bits (287), Expect = 9e-26
Identities = 91/320 (28%), Positives = 137/320 (42%), Gaps = 58/320 (18%)
Query: 113 LVGPSSVVCLPNGTWTGEQPHCRGISECSSQP-CQNGGTCVEGVNQYRCICPPGRTGNRC 171
L G + C P GEQ C I EC+ P C CV + C C PG
Sbjct: 193 LRGSFACQCPPGYQKRGEQ--CVDIDECTIPPYCHQ--RCVNTPGSFYCQCSPGFQ-LAA 247
Query: 172 QHQAQTDVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGL 231
+ D+NEC+ Q C C N GS+ C C GY +D +CED+DEC
Sbjct: 248 NNYTCVDINECDASNQ------CAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTS 301
Query: 232 QPVCPQGTTCINTGGSFQCVSP---------------------ECPEGSGNVSYVKTSPF 270
+C C+N G F C+ P EC E +Y F
Sbjct: 302 SYLCQY--QCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNY--HGGF 357
Query: 271 QC-ERNP--------------CPMDSRPCRHLPKTISFHYLSLPSNLKTPITLFRMATAS 315
+C RNP CP+ + CR LP++I + Y+S+ S+ P +F++ +
Sbjct: 358 RCYPRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATT 417
Query: 316 APGRAGPNSLR-FGIVGGNSRGHFVMQRSDRQTGDLILVQNLEGPQTLEVDVDMSEYLD- 373
N++ F I GN G F ++++ + L+LV++L GP+ VD++M
Sbjct: 418 IYA----NTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSI 473
Query: 374 RSFQANHVSKVTIFVSPYDF 393
+F+ + V ++TI V P+ F
Sbjct: 474 GTFRTSSVLRLTIIVGPFSF 493
Score = 35.4 bits (80), Expect = 0.090
Identities = 14/43 (32%), Positives = 21/43 (48%)
Query: 209 CPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCV 251
C GY + C+D+DEC + C G C+N G + C+
Sbjct: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL 71
>gi|9665262 EGF-containing fibulin-like extracellular matrix protein
1 precursor [Homo sapiens]
Length = 493
Score = 115 bits (287), Expect = 9e-26
Identities = 91/320 (28%), Positives = 137/320 (42%), Gaps = 58/320 (18%)
Query: 113 LVGPSSVVCLPNGTWTGEQPHCRGISECSSQP-CQNGGTCVEGVNQYRCICPPGRTGNRC 171
L G + C P GEQ C I EC+ P C CV + C C PG
Sbjct: 193 LRGSFACQCPPGYQKRGEQ--CVDIDECTIPPYCHQ--RCVNTPGSFYCQCSPGFQ-LAA 247
Query: 172 QHQAQTDVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGL 231
+ D+NEC+ Q C C N GS+ C C GY +D +CED+DEC
Sbjct: 248 NNYTCVDINECDASNQ------CAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTS 301
Query: 232 QPVCPQGTTCINTGGSFQCVSP---------------------ECPEGSGNVSYVKTSPF 270
+C C+N G F C+ P EC E +Y F
Sbjct: 302 SYLCQY--QCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNY--HGGF 357
Query: 271 QC-ERNP--------------CPMDSRPCRHLPKTISFHYLSLPSNLKTPITLFRMATAS 315
+C RNP CP+ + CR LP++I + Y+S+ S+ P +F++ +
Sbjct: 358 RCYPRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATT 417
Query: 316 APGRAGPNSLR-FGIVGGNSRGHFVMQRSDRQTGDLILVQNLEGPQTLEVDVDMSEYLD- 373
N++ F I GN G F ++++ + L+LV++L GP+ VD++M
Sbjct: 418 IYA----NTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSI 473
Query: 374 RSFQANHVSKVTIFVSPYDF 393
+F+ + V ++TI V P+ F
Sbjct: 474 GTFRTSSVLRLTIIVGPFSF 493
Score = 35.4 bits (80), Expect = 0.090
Identities = 14/43 (32%), Positives = 21/43 (48%)
Query: 209 CPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCV 251
C GY + C+D+DEC + C G C+N G + C+
Sbjct: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL 71
>gi|34734064 fibulin 1 isoform B precursor [Homo sapiens]
Length = 601
Score = 103 bits (258), Expect = 2e-22
Identities = 53/156 (33%), Positives = 75/156 (48%), Gaps = 6/156 (3%)
Query: 134 CRGISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRL 193
C I+ECSS PC C Y+C C G + D++EC L +
Sbjct: 439 CEDINECSSSPCSQ--ECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECAL---PTGGHI 493
Query: 194 CMHACVNTPGSYRCTCPG-GYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVS 252
C + C+N PGS++C+CP GYR +G++C+D+DECV C TC N G F+C++
Sbjct: 494 CSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLA 553
Query: 253 PECPEGSGNVSYVKTSPFQCERNPCPMDSRPCRHLP 288
ECPE + + S + P CR LP
Sbjct: 554 FECPENYRRSAATQKSKKGRQNTPAGSSKEDCRVLP 589
Score = 90.5 bits (223), Expect = 2e-18
Identities = 48/123 (39%), Positives = 61/123 (49%), Gaps = 11/123 (8%)
Query: 130 EQPHCRGISECS--SQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQ 187
E C + EC+ ++PC G CV +RC C G + DVNEC+ Y
Sbjct: 350 EGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMC-VDVNECQRYPG 408
Query: 188 EGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGS 247
RLC H C NT GSY C+C G+R DG+SCED++EC P C N GS
Sbjct: 409 ----RLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSS----SPCSQECANVYGS 460
Query: 248 FQC 250
+QC
Sbjct: 461 YQC 463
Score = 69.7 bits (169), Expect = 4e-12
Identities = 51/170 (30%), Positives = 69/170 (40%), Gaps = 21/170 (12%)
Query: 130 EQPHCRGISECSS--QPCQNGGTCVEGVNQYRCI----CPPGRTGNRCQHQAQTDVNECE 183
E C+ I EC S C C + +RC C G + + D+NEC
Sbjct: 256 EDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCI--DINECL 313
Query: 184 LYGQEGRPRLCMHACVNTPGSYRC-----TCPGGYRTLADGKSCEDVDECVGLQPVCPQG 238
P H C+NT GSY C C GY +G C DVDEC C +G
Sbjct: 314 SISA---PCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKG 370
Query: 239 TTCINTGGSFQCVSPECPEG--SGNVSYVKTSPFQCERNPCPMDSRPCRH 286
C+N+ GSF+C EC G +S + +C+R P + C +
Sbjct: 371 HRCVNSPGSFRC---ECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCEN 417
Score = 60.8 bits (146), Expect = 2e-09
Identities = 27/57 (47%), Positives = 35/57 (61%)
Query: 194 CMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQC 250
C C +T C+C GY+ L+DG SCEDV+EC+ C G +CINT GSF+C
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRC 242
Score = 57.8 bits (138), Expect = 2e-08
Identities = 51/161 (31%), Positives = 70/161 (43%), Gaps = 31/161 (19%)
Query: 134 CRGISECSSQPCQNGGTCVEGVNQYRCICPPG----RTGNRCQHQAQTDVNECELYGQEG 189
CRG C Q C++ G ++ C C G G C+ DVNEC
Sbjct: 180 CRGGGPCKQQ-CRDTG------DEVVCSCFVGYQLLSDGVSCE-----DVNECITGSHSC 227
Query: 190 RPRLCMHACVNTPGSYRC----TCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTG 245
R +C+NT GS+RC +C GY L + SC+D+DEC C C NT
Sbjct: 228 R---LGESCINTVGSFRCQRDSSCGTGYE-LTEDNSCKDIDECESGIHNCLPDFICQNTL 283
Query: 246 GSFQC-VSPECPEGSGNVSYVKTSPFQC-ERNPCPMDSRPC 284
GSF+C +C G +++ + C + N C S PC
Sbjct: 284 GSFRCRPKLQCKSG-----FIQDALGNCIDINECLSISAPC 319
>gi|122937283 6720455I24Rik homolog [Homo sapiens]
Length = 1413
Score = 103 bits (257), Expect = 3e-22
Identities = 66/184 (35%), Positives = 85/184 (46%), Gaps = 33/184 (17%)
Query: 105 FTCNPGFRLVGPSSV-VCLPNGTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICP 163
+ C+ G+ L PS + VC P+G W+ E P C I EC SQPC +GG+C + V Y C+C
Sbjct: 722 YACDRGYSLSAPSRIRVCQPHGVWS-EPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLCS 780
Query: 164 PGRTGNRCQHQAQTDVNECELYGQEGRPRLCMH--ACVNTPGSYRCTCPGGYRTLADGKS 221
G G CEL E R C + +C N PG+Y C CP G+ G
Sbjct: 781 TGYEG-----------AHCELERDECRAHPCRNGGSCRNLPGAYVCRCPAGF----VGVH 825
Query: 222 CE-DVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEGSGNVSYVKTSPFQCERNPCPMD 280
CE +VD C C G C + GG++ CV PE G + CE P
Sbjct: 826 CETEVDACD--SSPCQHGGRCESGGGAYLCVCPESFFG-----------YHCETVSDPCF 872
Query: 281 SRPC 284
S PC
Sbjct: 873 SSPC 876
Score = 92.4 bits (228), Expect = 6e-19
Identities = 58/167 (34%), Positives = 79/167 (47%), Gaps = 19/167 (11%)
Query: 113 LVGPSSVVCLPNGTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQ 172
+ G S C +TG + H ++EC+SQPCQNGGTC G+N +RC CP G G C+
Sbjct: 289 VTGNPSYTCSCLSGFTGRRCHL-DVNECASQPCQNGGTCTHGINSFRCQCPAGFGGPTCE 347
Query: 173 -HQAQTDVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCE-DVDECVG 230
Q+ D EC+ GQ C GS C C GY G +CE DVD+C
Sbjct: 348 TAQSPCDTKECQHGGQ----------CQVENGSAVCVCQAGY----TGAACEMDVDDC-- 391
Query: 231 LQPVCPQGTTCINTGGSFQCVSPECPEGSGNVSYVKTSPFQCERNPC 277
C G +C++ G++ C+ E +G + P C PC
Sbjct: 392 SPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPC 438
Score = 70.1 bits (170), Expect = 3e-12
Identities = 47/149 (31%), Positives = 61/149 (40%), Gaps = 34/149 (22%)
Query: 138 SECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMH- 196
S C S PC NGG+C + Y C CP G G C ++ RP LC
Sbjct: 543 SPCDSDPCFNGGSCDAHDDSYTCECPRGFHGKHC---------------EKARPHLCSSG 587
Query: 197 ------ACVNTPGSYRCTCPGGYRTLADGKSCE--DVDECVGLQPVCPQGTTCINTGGSF 248
C G Y C+CP YR G+ CE D C C G TC + G +
Sbjct: 588 PCRNGGTCKEAGGEYHCSCP--YR--FTGRHCEIGKPDSCA--SGPCHNGGTCFHYIGKY 641
Query: 249 QCVSPECPEGSGNVSYVKTSPFQCERNPC 277
+C +CP G + + +P C R+PC
Sbjct: 642 KC---DCPPGFSG-RHCEIAPSPCFRSPC 666
Score = 64.3 bits (155), Expect = 2e-10
Identities = 56/183 (30%), Positives = 75/183 (40%), Gaps = 35/183 (19%)
Query: 107 CNPGFRLVGPSSVVCLPNGTWTGEQPHCRGI----------SECSSQPCQNGGTCVEGVN 156
C+P L G S V + N T +P +G+ C S PC NGGTCV+
Sbjct: 391 CSPDPCLNGGSCVDLVGNYTCLCAEPF-KGLRCETGDHPVPDACLSAPCHNGGTCVDADQ 449
Query: 157 QYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTL 216
Y C CP G G C+ + D EC G+ C+ A + C CP G+
Sbjct: 450 GYVCECPEGFMGLDCRERVPDDC-ECRNGGR------CLGA-----NTTLCQCPLGF--- 494
Query: 217 ADGKSCEDVDECV--GLQPVCPQGTTCINTGGSFQCVSPECPEGSGNVSYVKTSPFQCER 274
G CE + + CP G C+ GGS+ CV N S+ SP C+
Sbjct: 495 -FGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVC----HTDHNASHSLPSP--CDS 547
Query: 275 NPC 277
+PC
Sbjct: 548 DPC 550
Score = 62.4 bits (150), Expect = 7e-10
Identities = 38/118 (32%), Positives = 47/118 (39%), Gaps = 27/118 (22%)
Query: 140 CSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMH--- 196
CSS PC+NGGTC E +Y C CP TG C + G+P C
Sbjct: 584 CSSGPCRNGGTCKEAGGEYHCSCPYRFTGRHC---------------EIGKPDSCASGPC 628
Query: 197 ----ACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQC 250
C + G Y+C CP G+ G+ CE P C G TC + F C
Sbjct: 629 HNGGTCFHYIGKYKCDCPPGF----SGRHCEIAPSPCFRSP-CVNGGTCEDRDTDFFC 681
Score = 58.2 bits (139), Expect = 1e-08
Identities = 43/139 (30%), Positives = 55/139 (39%), Gaps = 22/139 (15%)
Query: 143 QPCQNGGTCVE----GVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMHAC 198
+PC NGG C++ G Y C C G TG RC DVNEC +P C
Sbjct: 276 RPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRC----HLDVNEC-----ASQPCQNGGTC 326
Query: 199 VNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEG 258
+ S+RC CP G+ G +CE + C G C GS CV C G
Sbjct: 327 THGINSFRCQCPAGF----GGPTCETAQSPCDTKE-CQHGGQCQVENGSAVCV---CQAG 378
Query: 259 SGNVSYVKTSPFQCERNPC 277
+ + C +PC
Sbjct: 379 YTGAA-CEMDVDDCSPDPC 396
Score = 57.8 bits (138), Expect = 2e-08
Identities = 49/208 (23%), Positives = 75/208 (36%), Gaps = 53/208 (25%)
Query: 127 WTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQ-------------- 172
+TG C+S PC NGGTC + +Y+C CPPG +G C+
Sbjct: 610 FTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCVNG 669
Query: 173 ---HQAQTDV----------NECELYGQEGRPRLCMHACVNTPGS-------------YR 206
TD C+ G P HA + G+ Y
Sbjct: 670 GTCEDRDTDFFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYS 729
Query: 207 CTCPGGYRTL------ADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEGSG 260
+ P R ++ C ++DEC QP C G +C + + C+ EG
Sbjct: 730 LSAPSRIRVCQPHGVWSEPPQCLEIDECRS-QP-CLHGGSCQDRVAGYLCLCSTGYEG-- 785
Query: 261 NVSYVKTSPFQCERNPCPMDSRPCRHLP 288
++ + +C +PC + CR+LP
Sbjct: 786 --AHCELERDECRAHPC-RNGGSCRNLP 810
Score = 52.4 bits (124), Expect = 7e-07
Identities = 33/94 (35%), Positives = 45/94 (47%), Gaps = 18/94 (19%)
Query: 194 CMHACVNTPGSYRCTCPGGYRTLADGKSCE-DVDECVGLQPVCPQGTTCINTGGSFQCVS 252
C+ CV SY C+C G+ G+ C DV+EC QP C G TC + SF+C
Sbjct: 284 CIDDCVTGNPSYTCSCLSGFT----GRRCHLDVNECAS-QP-CQNGGTCTHGINSFRC-- 335
Query: 253 PECPEGSGNVSYVKTSPFQCERNPCPMDSRPCRH 286
+CP G G + CE P D++ C+H
Sbjct: 336 -QCPAGFGGPT--------CETAQSPCDTKECQH 360
Score = 50.8 bits (120), Expect = 2e-06
Identities = 19/33 (57%), Positives = 22/33 (66%)
Query: 140 CSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQ 172
CS PCQNGGTCV G + + C C PG G RC+
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCE 1343
Score = 36.2 bits (82), Expect = 0.053
Identities = 15/40 (37%), Positives = 19/40 (47%), Gaps = 1/40 (2%)
Query: 133 HCRGISE-CSSQPCQNGGTCVEGVNQYRCICPPGRTGNRC 171
HC +S+ C S PC G C+ + C C G TG C
Sbjct: 863 HCETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGEDC 902
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 100 bits (250), Expect = 2e-21
Identities = 68/236 (28%), Positives = 100/236 (42%), Gaps = 19/236 (8%)
Query: 159 RCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLAD 218
R CP G + H D++ECE C H C NT GSY+C CP GY+ +
Sbjct: 5416 RKTCPEG---SEASHDTCVDIDECE------NTDACQHECKNTFGSYQCICPPGYQLTHN 5466
Query: 219 GKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEGSGNVSYVKTSPFQCERNPCP 278
GK+C+D+DEC+ C C N GS+QC+ CP N S F C +N CP
Sbjct: 5467 GKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTPCPP---NYQRDPVSGF-CLKN-CP 5521
Query: 279 MDSRPCRHLPKTISFHYLSLPSNLKTPITLFRMATASAPGRAGPNSLRFGIVGGNSRGHF 338
+ C P + + +SLP + T L R+ + G P + F +V F
Sbjct: 5522 PNDLECALSPYALEYKLVSLPFGIATNQDLIRLVAYTQDGVMHPRT-TFLMVDEEQTVPF 5580
Query: 339 VMQRSDRQTGDLILVQNLEGPQTLEVDVDMSEYLDR---SFQANHVSKVTIFVSPY 391
+ R + G + + L +T + V S Y +Q + + + PY
Sbjct: 5581 AL-RDENLKGVVYTTRPLREAETYRMRVRASSYSANGTIEYQTTFIVYIAVSAYPY 5635
Score = 84.3 bits (207), Expect = 2e-16
Identities = 51/157 (32%), Positives = 71/157 (45%), Gaps = 28/157 (17%)
Query: 104 HFTCNPGFRLVGPSSVVCLPNGTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCI-- 161
H C PG++L G C ++EC C+ C Y+CI
Sbjct: 5214 HCGCEPGYQLKGRK----------------CMDVNECRQNVCRPDQHCKNTRGGYKCIDL 5257
Query: 162 CPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKS 221
CP G T + ++ D++EC+ + R C NT GSYRC CP GYR+ G+
Sbjct: 5258 CPNGMT--KAENGTCIDIDECKDGTHQCRYN---QICENTRGSYRCVCPRGYRSQGVGRP 5312
Query: 222 CEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEG 258
C D++EC + C C NT GSF+C+ CP G
Sbjct: 5313 CMDINECEQVPKPCAH--QCSNTPGSFKCI---CPPG 5344
Score = 79.3 bits (194), Expect = 5e-15
Identities = 42/110 (38%), Positives = 51/110 (46%), Gaps = 16/110 (14%)
Query: 123 PNGTWTGEQPHCRGISECS--SQPCQNGGTCVEGVNQYRCICPPGR----TGNRCQHQAQ 176
PNG E C I EC + C+ C YRC+CP G G C
Sbjct: 5259 PNGMTKAENGTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCM---- 5314
Query: 177 TDVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVD 226
D+NECE P+ C H C NTPGS++C CP G L DGKSC ++
Sbjct: 5315 -DINECEQV-----PKPCAHQCSNTPGSFKCICPPGQHLLGDGKSCAGLE 5358
Score = 77.0 bits (188), Expect = 3e-14
Identities = 62/186 (33%), Positives = 77/186 (41%), Gaps = 33/186 (17%)
Query: 115 GPSSVVCLPNGTWTGEQPHCRGISECSS-QPCQNGGTCVEGVNQYRCICPPGRT----GN 169
G S C T P C EC++ PC + +C + Y C CP G T G
Sbjct: 5086 GDRSNQCPSGFTLDSVGPFCADEDECAAGNPCSH--SCHNAMGTYYCSCPKGLTIAADGR 5143
Query: 170 RCQHQAQTDVNECELYGQEGRPRLCMHA---CVNTPGSYRCT--CPGGYRTLADGKSCED 224
CQ D++EC L R HA C NT GSYRC C G+R +DG SC+D
Sbjct: 5144 TCQ-----DIDECAL------GRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQD 5192
Query: 225 VDECVGLQPVCPQGTTCINTGGSFQCVSPECPEGSGNVSYVKTSPFQCERNPCPMDSRPC 284
++EC Q P C N GSF C C G +C +N C RP
Sbjct: 5193 INEC---QESSPCHQRCFNAIGSFHC---GCEPGYQLKGRKCMDVNECRQNVC----RPD 5242
Query: 285 RHLPKT 290
+H T
Sbjct: 5243 QHCKNT 5248
Score = 73.6 bits (179), Expect = 3e-13
Identities = 63/210 (30%), Positives = 81/210 (38%), Gaps = 56/210 (26%)
Query: 134 CRGISECS--SQPCQNGGTCVEGVNQYRCI--CPPG--RT--GNRCQHQAQTDVNECELY 185
C+ I EC+ C G C + YRC+ C G RT G CQ D+NEC
Sbjct: 5145 CQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQ-----DINEC--- 5196
Query: 186 GQEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTG 245
QE P C C N GS+ C C GY+ G+ C DV+EC Q VC C NT
Sbjct: 5197 -QESSP--CHQRCFNAIGSFHCGCEPGYQ--LKGRKCMDVNEC--RQNVCRPDQHCKNTR 5249
Query: 246 GSFQCVSPECPEGSG--------NVSYVKTSPFQCERNP------------CP------- 278
G ++C+ CP G ++ K QC N CP
Sbjct: 5250 GGYKCID-LCPNGMTKAENGTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQG 5308
Query: 279 -----MDSRPCRHLPKTISFHYLSLPSNLK 303
MD C +PK + + P + K
Sbjct: 5309 VGRPCMDINECEQVPKPCAHQCSNTPGSFK 5338
Score = 43.9 bits (102), Expect = 3e-04
Identities = 30/89 (33%), Positives = 38/89 (42%), Gaps = 18/89 (20%)
Query: 134 CRGISEC-SSQPCQNGGTCVEGVNQYRCICPPG----RTGNRCQHQAQTDVNECELYGQE 188
C I EC ++ CQ+ C Y+CICPPG G CQ D++EC
Sbjct: 5430 CVDIDECENTDACQH--ECKNTFGSYQCICPPGYQLTHNGKTCQ-----DIDECLEQNVH 5482
Query: 189 GRPRLCMHACVNTPGSYRC---TCPGGYR 214
P C N GSY+C CP Y+
Sbjct: 5483 CGPN---RMCFNMRGSYQCIDTPCPPNYQ 5508
>gi|110347437 latent transforming growth factor beta binding protein
4 isoform c [Homo sapiens]
Length = 1557
Score = 100 bits (248), Expect = 3e-21
Identities = 66/199 (33%), Positives = 88/199 (44%), Gaps = 26/199 (13%)
Query: 101 HEVHFTCNPGFRLVGPSSVVCL-PNGTWTGEQPH---CRGISECSSQPCQNG-GTCVEGV 155
H V C+ G P S +C+ P G PH C+ + EC+ P G G C
Sbjct: 567 HRVPPPCDLGRCENTPGSFLCVCPAGYQAA--PHGASCQDVDECTQSPGLCGRGACKNLP 624
Query: 156 NQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRT 215
+RC+CP G G+ C+ DV+EC + P C NT GS+ C CP G+R+
Sbjct: 625 GSFRCVCPAGFRGSACEE----DVDECA----QEPPPCGPGRCDNTAGSFHCACPAGFRS 676
Query: 216 LADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSP----------ECPEGSGNVSYV 265
G C+DVDEC P C G C NT GSFQCV P EC + +++
Sbjct: 677 RGPGAPCQDVDECARSPPPCTYG-RCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHL 735
Query: 266 KTSPFQCERNPCPMDSRPC 284
+C +P R C
Sbjct: 736 ACPGQECVNSPGSFQCRTC 754
Score = 94.0 bits (232), Expect = 2e-19
Identities = 70/219 (31%), Positives = 90/219 (41%), Gaps = 18/219 (8%)
Query: 71 RVGPDALPVSCPALNTPADGRKFGSKYLVDHEVHFTCNPGFRLVGPSSVVCLPNGTW--T 128
R GP+ S PA P S + C PG + PS C + + +
Sbjct: 454 RPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQ-VCGPGRCISRPSGYTCACDSGFRLS 512
Query: 129 GEQPHCRGISECSS--QPCQNGGTCVEGVNQYRCICPPG-RTGNRCQHQAQTDVNECELY 185
+ C + EC PC G C +RC+C PG R G R DV+EC
Sbjct: 513 PQGTRCIDVDECRRVPPPCAPG-RCENSPGSFRCVCGPGFRAGPRAAECL--DVDECHRV 569
Query: 186 GQEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTG 245
P + C NTPGS+ C CP GY+ G SC+DVDEC +C +G C N
Sbjct: 570 P----PPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRG-ACKNLP 624
Query: 246 GSFQCVSPECPEGSGNVSYVKTSPFQCERNPCPMDSRPC 284
GSF+CV P GS V +C + P P C
Sbjct: 625 GSFRCVCPAGFRGSACEEDVD----ECAQEPPPCGPGRC 659
Score = 82.8 bits (203), Expect = 5e-16
Identities = 70/239 (29%), Positives = 88/239 (36%), Gaps = 69/239 (28%)
Query: 70 GRVGPDALPVSCPALNTPADGR---KFGSKYLVDHEVHFTCNPGFRLVGPSSVVCLPNGT 126
G P P C +N +G G D TC PG+R GP CL
Sbjct: 798 GYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYR-PGPRGASCLD--- 853
Query: 127 WTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPPG-RTG----------------- 168
+ ECS + G C + CICPPG R G
Sbjct: 854 ----------VDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGP 903
Query: 169 -----NRCQHQAQT--------------------DVNECELYGQEGRPRLC-MHACVNTP 202
RC++ + DV+EC+ YG P +C C NTP
Sbjct: 904 ALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYG----PEICGAQRCENTP 959
Query: 203 GSYRCT--CPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEGS 259
GSYRCT C GY+ G C+DVDEC + C C N GSFQC+ + EG+
Sbjct: 960 GSYRCTPACDPGYQPTPGG-GCQDVDECRN-RSFCGAHAVCQNLPGSFQCLCDQGYEGA 1016
Score = 81.6 bits (200), Expect = 1e-15
Identities = 56/157 (35%), Positives = 73/157 (46%), Gaps = 40/157 (25%)
Query: 104 HFTCNPGFRLVGPSSVVCLPNGTWTGEQPHCRGISECS-SQPCQNGGTCVEGVNQYRCIC 162
H C GFR GP + C+ + EC+ S P G C ++C+C
Sbjct: 667 HCACPAGFRSRGPGAP--------------CQDVDECARSPPPCTYGRCENTEGSFQCVC 712
Query: 163 P----PGRTGNRCQHQAQTDVNECELY----GQEGRPRLCMHACVNTPGSYRC-TCPGGY 213
P P G+ C+ DV+ECE + GQE CVN+PGS++C TCP G+
Sbjct: 713 PMGFQPNTAGSECE-----DVDECENHLACPGQE---------CVNSPGSFQCRTCPSGH 758
Query: 214 RTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQC 250
L G+ C DVDEC P C C NT GSF+C
Sbjct: 759 H-LHRGR-CTDVDECSSGAPPCGPHGHCTNTEGSFRC 793
Score = 78.2 bits (191), Expect = 1e-14
Identities = 56/153 (36%), Positives = 66/153 (43%), Gaps = 22/153 (14%)
Query: 116 PSSVVCLPN---GTWTGEQPHCRGISECSSQPCQNGGT--CVEGVNQYRCI--CPPG--- 165
P S C+ + G G + C + EC + G C YRC C PG
Sbjct: 915 PGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQP 974
Query: 166 RTGNRCQHQAQTDVNECELYGQEGRPRLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCED 224
G CQ DV+EC R HA C N PGS++C C GY DG+ C D
Sbjct: 975 TPGGGCQ-----DVDECR-----NRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVD 1024
Query: 225 VDECVGLQPVCPQGTTCINTGGSFQCVSPECPE 257
V+EC LQ VC C N GSF CV P PE
Sbjct: 1025 VNECETLQGVC-GAALCENVEGSFLCVCPNSPE 1056
Score = 73.6 bits (179), Expect = 3e-13
Identities = 63/199 (31%), Positives = 75/199 (37%), Gaps = 45/199 (22%)
Query: 102 EVHFTCNPGFRLVG-PSSVVC--LPNGTWTGEQPHCRGISECSS--QPCQNGGTCVEGVN 156
E H C PG V P S C P+G + C + ECSS PC G C
Sbjct: 732 ENHLAC-PGQECVNSPGSFQCRTCPSGHHL-HRGRCTDVDECSSGAPPCGPHGHCTNTEG 789
Query: 157 QYRCICPPGRTGNRCQHQAQTDVNEC----------ELYGQEGR------------PR-- 192
+RC C PG + DVNEC E +G PR
Sbjct: 790 SFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGA 849
Query: 193 ------------LCMHA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGT 239
LC C NT GS+ C CP G+R D SC DVDEC P
Sbjct: 850 SCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQ 909
Query: 240 TCINTGGSFQCVSPECPEG 258
C N+ GS++CV +C G
Sbjct: 910 RCENSPGSYRCVR-DCDPG 927
Score = 69.7 bits (169), Expect = 4e-12
Identities = 43/120 (35%), Positives = 56/120 (46%), Gaps = 11/120 (9%)
Query: 134 CRGISECSSQPCQNGGTCVEGVNQYRC-ICPPGRTGNRCQHQAQTDVNECELYGQEGRPR 192
C + EC + G CV ++C CP +G+ TDV+EC G P
Sbjct: 725 CEDVDECENHLACPGQECVNSPGSFQCRTCP---SGHHLHRGRCTDVDECS----SGAPP 777
Query: 193 LCMHA-CVNTPGSYRCTCPGGYRTLADGKS-CEDVDECVGLQPVCPQGTTCINTGGSFQC 250
H C NT GS+RC+C GYR + C DV+EC+ P G C+NT GSF C
Sbjct: 778 CGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHG-ECLNTDGSFAC 836
Score = 65.9 bits (159), Expect = 6e-11
Identities = 40/116 (34%), Positives = 53/116 (45%), Gaps = 13/116 (11%)
Query: 138 SECSSQPCQNGGTCVEGVNQYRCICPPGR--TGNRCQHQAQTDVNECELYGQEGRPRLCM 195
S C Q C T +Y+ +CP GR + DV+EC+L+ R ++C
Sbjct: 1149 SGCRIQQCPGTETA-----EYQSLCPHGRGYLAPSGDLSLRRDVDECQLF----RDQVCK 1199
Query: 196 HA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQC 250
CVNT Y C C GY C D DEC +P C +G C+NT GS+ C
Sbjct: 1200 SGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPAC-EGGRCVNTVGSYHC 1254
Score = 45.8 bits (107), Expect = 7e-05
Identities = 21/57 (36%), Positives = 29/57 (50%), Gaps = 4/57 (7%)
Query: 198 CVNTPGSYRCTCPGGYRTLADGKSCEDVDEC---VGLQPVCPQGTTCINTGGSFQCV 251
CV P + C C GYR +C D++EC P+C C+NT GSF+C+
Sbjct: 1481 CVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLC-VNARCLNTDGSFRCI 1536
Score = 42.0 bits (97), Expect = 0.001
Identities = 26/76 (34%), Positives = 36/76 (47%), Gaps = 4/76 (5%)
Query: 139 ECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMHA- 197
EC G CV + C C G + + A D+NEC+ E LC++A
Sbjct: 1469 ECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTR-MACVDINECD--EAEAASPLCVNAR 1525
Query: 198 CVNTPGSYRCTCPGGY 213
C+NT GS+RC C G+
Sbjct: 1526 CLNTDGSFRCICRPGF 1541
Score = 40.4 bits (93), Expect = 0.003
Identities = 43/137 (31%), Positives = 55/137 (40%), Gaps = 22/137 (16%)
Query: 149 GTCVEGVNQYRCICP-PG-RTGNRCQHQAQT--DVNECELYGQEGRPRLCMHACVNTPGS 204
G C + C P PG RT C A V++C+L + RL V+ P
Sbjct: 220 GYCFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSE----RLGNSERVSAPDG 275
Query: 205 YRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEG----SG 260
CP G+ + SCEDVDEC C G C NT G + CV CP+G S
Sbjct: 276 ---PCPTGFERV--NGSCEDVDEC-ATGGRCQHG-ECANTRGGYTCV---CPDGFLLDSS 325
Query: 261 NVSYVKTSPFQCERNPC 277
S + + PC
Sbjct: 326 RSSCISQHVISEAKGPC 342
Score = 33.9 bits (76), Expect = 0.26
Identities = 24/84 (28%), Positives = 37/84 (44%), Gaps = 8/84 (9%)
Query: 134 CRGISECSSQ-PCQNGGTCVEGVNQYRCICPP----GRTGNRC-QHQAQT-DVNECELYG 186
C EC+ + P GG CV V Y C C P + RC +++Q+ D N +
Sbjct: 1227 CIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQ 1286
Query: 187 QEGRPRLCMHACVNTPGSY-RCTC 209
+ G +C H ++ +Y C C
Sbjct: 1287 EVGADLVCSHPRLDRQATYTECCC 1310
Score = 33.5 bits (75), Expect = 0.34
Identities = 14/28 (50%), Positives = 16/28 (57%), Gaps = 3/28 (10%)
Query: 145 CQNGGTCVEGVNQYRCICPPGRTGNRCQ 172
C NGG CV+ RC+CPP G CQ
Sbjct: 90 CHNGGVCVK---PDRCLCPPDFAGKFCQ 114
>gi|110347412 latent transforming growth factor beta binding protein
4 isoform b [Homo sapiens]
Length = 1587
Score = 100 bits (248), Expect = 3e-21
Identities = 66/199 (33%), Positives = 88/199 (44%), Gaps = 26/199 (13%)
Query: 101 HEVHFTCNPGFRLVGPSSVVCL-PNGTWTGEQPH---CRGISECSSQPCQNG-GTCVEGV 155
H V C+ G P S +C+ P G PH C+ + EC+ P G G C
Sbjct: 597 HRVPPPCDLGRCENTPGSFLCVCPAGYQAA--PHGASCQDVDECTQSPGLCGRGACKNLP 654
Query: 156 NQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRT 215
+RC+CP G G+ C+ DV+EC + P C NT GS+ C CP G+R+
Sbjct: 655 GSFRCVCPAGFRGSACEE----DVDECA----QEPPPCGPGRCDNTAGSFHCACPAGFRS 706
Query: 216 LADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSP----------ECPEGSGNVSYV 265
G C+DVDEC P C G C NT GSFQCV P EC + +++
Sbjct: 707 RGPGAPCQDVDECARSPPPCTYG-RCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHL 765
Query: 266 KTSPFQCERNPCPMDSRPC 284
+C +P R C
Sbjct: 766 ACPGQECVNSPGSFQCRTC 784
Score = 94.0 bits (232), Expect = 2e-19
Identities = 70/219 (31%), Positives = 90/219 (41%), Gaps = 18/219 (8%)
Query: 71 RVGPDALPVSCPALNTPADGRKFGSKYLVDHEVHFTCNPGFRLVGPSSVVCLPNGTW--T 128
R GP+ S PA P S + C PG + PS C + + +
Sbjct: 484 RPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQ-VCGPGRCISRPSGYTCACDSGFRLS 542
Query: 129 GEQPHCRGISECSS--QPCQNGGTCVEGVNQYRCICPPG-RTGNRCQHQAQTDVNECELY 185
+ C + EC PC G C +RC+C PG R G R DV+EC
Sbjct: 543 PQGTRCIDVDECRRVPPPCAPG-RCENSPGSFRCVCGPGFRAGPRAAECL--DVDECHRV 599
Query: 186 GQEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTG 245
P + C NTPGS+ C CP GY+ G SC+DVDEC +C +G C N
Sbjct: 600 P----PPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRG-ACKNLP 654
Query: 246 GSFQCVSPECPEGSGNVSYVKTSPFQCERNPCPMDSRPC 284
GSF+CV P GS V +C + P P C
Sbjct: 655 GSFRCVCPAGFRGSACEEDVD----ECAQEPPPCGPGRC 689
Score = 82.8 bits (203), Expect = 5e-16
Identities = 70/239 (29%), Positives = 88/239 (36%), Gaps = 69/239 (28%)
Query: 70 GRVGPDALPVSCPALNTPADGR---KFGSKYLVDHEVHFTCNPGFRLVGPSSVVCLPNGT 126
G P P C +N +G G D TC PG+R GP CL
Sbjct: 828 GYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYR-PGPRGASCLD--- 883
Query: 127 WTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPPG-RTG----------------- 168
+ ECS + G C + CICPPG R G
Sbjct: 884 ----------VDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGP 933
Query: 169 -----NRCQHQAQT--------------------DVNECELYGQEGRPRLC-MHACVNTP 202
RC++ + DV+EC+ YG P +C C NTP
Sbjct: 934 ALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYG----PEICGAQRCENTP 989
Query: 203 GSYRCT--CPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEGS 259
GSYRCT C GY+ G C+DVDEC + C C N GSFQC+ + EG+
Sbjct: 990 GSYRCTPACDPGYQPTPGG-GCQDVDECRN-RSFCGAHAVCQNLPGSFQCLCDQGYEGA 1046
Score = 81.6 bits (200), Expect = 1e-15
Identities = 56/157 (35%), Positives = 73/157 (46%), Gaps = 40/157 (25%)
Query: 104 HFTCNPGFRLVGPSSVVCLPNGTWTGEQPHCRGISECS-SQPCQNGGTCVEGVNQYRCIC 162
H C GFR GP + C+ + EC+ S P G C ++C+C
Sbjct: 697 HCACPAGFRSRGPGAP--------------CQDVDECARSPPPCTYGRCENTEGSFQCVC 742
Query: 163 P----PGRTGNRCQHQAQTDVNECELY----GQEGRPRLCMHACVNTPGSYRC-TCPGGY 213
P P G+ C+ DV+ECE + GQE CVN+PGS++C TCP G+
Sbjct: 743 PMGFQPNTAGSECE-----DVDECENHLACPGQE---------CVNSPGSFQCRTCPSGH 788
Query: 214 RTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQC 250
L G+ C DVDEC P C C NT GSF+C
Sbjct: 789 H-LHRGR-CTDVDECSSGAPPCGPHGHCTNTEGSFRC 823
Score = 78.2 bits (191), Expect = 1e-14
Identities = 56/153 (36%), Positives = 66/153 (43%), Gaps = 22/153 (14%)
Query: 116 PSSVVCLPN---GTWTGEQPHCRGISECSSQPCQNGGT--CVEGVNQYRCI--CPPG--- 165
P S C+ + G G + C + EC + G C YRC C PG
Sbjct: 945 PGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQP 1004
Query: 166 RTGNRCQHQAQTDVNECELYGQEGRPRLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCED 224
G CQ DV+EC R HA C N PGS++C C GY DG+ C D
Sbjct: 1005 TPGGGCQ-----DVDECR-----NRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVD 1054
Query: 225 VDECVGLQPVCPQGTTCINTGGSFQCVSPECPE 257
V+EC LQ VC C N GSF CV P PE
Sbjct: 1055 VNECETLQGVC-GAALCENVEGSFLCVCPNSPE 1086
Score = 73.6 bits (179), Expect = 3e-13
Identities = 63/199 (31%), Positives = 75/199 (37%), Gaps = 45/199 (22%)
Query: 102 EVHFTCNPGFRLVG-PSSVVC--LPNGTWTGEQPHCRGISECSS--QPCQNGGTCVEGVN 156
E H C PG V P S C P+G + C + ECSS PC G C
Sbjct: 762 ENHLAC-PGQECVNSPGSFQCRTCPSGHHL-HRGRCTDVDECSSGAPPCGPHGHCTNTEG 819
Query: 157 QYRCICPPGRTGNRCQHQAQTDVNEC----------ELYGQEGR------------PR-- 192
+RC C PG + DVNEC E +G PR
Sbjct: 820 SFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGA 879
Query: 193 ------------LCMHA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGT 239
LC C NT GS+ C CP G+R D SC DVDEC P
Sbjct: 880 SCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQ 939
Query: 240 TCINTGGSFQCVSPECPEG 258
C N+ GS++CV +C G
Sbjct: 940 RCENSPGSYRCVR-DCDPG 957
Score = 69.7 bits (169), Expect = 4e-12
Identities = 43/120 (35%), Positives = 56/120 (46%), Gaps = 11/120 (9%)
Query: 134 CRGISECSSQPCQNGGTCVEGVNQYRC-ICPPGRTGNRCQHQAQTDVNECELYGQEGRPR 192
C + EC + G CV ++C CP +G+ TDV+EC G P
Sbjct: 755 CEDVDECENHLACPGQECVNSPGSFQCRTCP---SGHHLHRGRCTDVDECS----SGAPP 807
Query: 193 LCMHA-CVNTPGSYRCTCPGGYRTLADGKS-CEDVDECVGLQPVCPQGTTCINTGGSFQC 250
H C NT GS+RC+C GYR + C DV+EC+ P G C+NT GSF C
Sbjct: 808 CGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHG-ECLNTDGSFAC 866
Score = 65.9 bits (159), Expect = 6e-11
Identities = 40/116 (34%), Positives = 53/116 (45%), Gaps = 13/116 (11%)
Query: 138 SECSSQPCQNGGTCVEGVNQYRCICPPGR--TGNRCQHQAQTDVNECELYGQEGRPRLCM 195
S C Q C T +Y+ +CP GR + DV+EC+L+ R ++C
Sbjct: 1179 SGCRIQQCPGTETA-----EYQSLCPHGRGYLAPSGDLSLRRDVDECQLF----RDQVCK 1229
Query: 196 HA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQC 250
CVNT Y C C GY C D DEC +P C +G C+NT GS+ C
Sbjct: 1230 SGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPAC-EGGRCVNTVGSYHC 1284
Score = 45.8 bits (107), Expect = 7e-05
Identities = 21/57 (36%), Positives = 29/57 (50%), Gaps = 4/57 (7%)
Query: 198 CVNTPGSYRCTCPGGYRTLADGKSCEDVDEC---VGLQPVCPQGTTCINTGGSFQCV 251
CV P + C C GYR +C D++EC P+C C+NT GSF+C+
Sbjct: 1511 CVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLC-VNARCLNTDGSFRCI 1566
Score = 42.0 bits (97), Expect = 0.001
Identities = 26/76 (34%), Positives = 36/76 (47%), Gaps = 4/76 (5%)
Query: 139 ECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMHA- 197
EC G CV + C C G + + A D+NEC+ E LC++A
Sbjct: 1499 ECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTR-MACVDINECD--EAEAASPLCVNAR 1555
Query: 198 CVNTPGSYRCTCPGGY 213
C+NT GS+RC C G+
Sbjct: 1556 CLNTDGSFRCICRPGF 1571
Score = 40.4 bits (93), Expect = 0.003
Identities = 43/137 (31%), Positives = 55/137 (40%), Gaps = 22/137 (16%)
Query: 149 GTCVEGVNQYRCICP-PG-RTGNRCQHQAQT--DVNECELYGQEGRPRLCMHACVNTPGS 204
G C + C P PG RT C A V++C+L + RL V+ P
Sbjct: 250 GYCFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSE----RLGNSERVSAPDG 305
Query: 205 YRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEG----SG 260
CP G+ + SCEDVDEC C G C NT G + CV CP+G S
Sbjct: 306 ---PCPTGFERV--NGSCEDVDEC-ATGGRCQHG-ECANTRGGYTCV---CPDGFLLDSS 355
Query: 261 NVSYVKTSPFQCERNPC 277
S + + PC
Sbjct: 356 RSSCISQHVISEAKGPC 372
Score = 33.9 bits (76), Expect = 0.26
Identities = 24/84 (28%), Positives = 37/84 (44%), Gaps = 8/84 (9%)
Query: 134 CRGISECSSQ-PCQNGGTCVEGVNQYRCICPP----GRTGNRC-QHQAQT-DVNECELYG 186
C EC+ + P GG CV V Y C C P + RC +++Q+ D N +
Sbjct: 1257 CIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQ 1316
Query: 187 QEGRPRLCMHACVNTPGSY-RCTC 209
+ G +C H ++ +Y C C
Sbjct: 1317 EVGADLVCSHPRLDRQATYTECCC 1340
Score = 33.5 bits (75), Expect = 0.34
Identities = 14/28 (50%), Positives = 16/28 (57%), Gaps = 3/28 (10%)
Query: 145 CQNGGTCVEGVNQYRCICPPGRTGNRCQ 172
C NGG CV+ RC+CPP G CQ
Sbjct: 120 CHNGGVCVK---PDRCLCPPDFAGKFCQ 144
>gi|110347431 latent transforming growth factor beta binding protein
4 isoform a [Homo sapiens]
Length = 1624
Score = 100 bits (248), Expect = 3e-21
Identities = 66/199 (33%), Positives = 88/199 (44%), Gaps = 26/199 (13%)
Query: 101 HEVHFTCNPGFRLVGPSSVVCL-PNGTWTGEQPH---CRGISECSSQPCQNG-GTCVEGV 155
H V C+ G P S +C+ P G PH C+ + EC+ P G G C
Sbjct: 634 HRVPPPCDLGRCENTPGSFLCVCPAGYQAA--PHGASCQDVDECTQSPGLCGRGACKNLP 691
Query: 156 NQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRT 215
+RC+CP G G+ C+ DV+EC + P C NT GS+ C CP G+R+
Sbjct: 692 GSFRCVCPAGFRGSACEE----DVDECA----QEPPPCGPGRCDNTAGSFHCACPAGFRS 743
Query: 216 LADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSP----------ECPEGSGNVSYV 265
G C+DVDEC P C G C NT GSFQCV P EC + +++
Sbjct: 744 RGPGAPCQDVDECARSPPPCTYG-RCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHL 802
Query: 266 KTSPFQCERNPCPMDSRPC 284
+C +P R C
Sbjct: 803 ACPGQECVNSPGSFQCRTC 821
Score = 94.0 bits (232), Expect = 2e-19
Identities = 70/219 (31%), Positives = 90/219 (41%), Gaps = 18/219 (8%)
Query: 71 RVGPDALPVSCPALNTPADGRKFGSKYLVDHEVHFTCNPGFRLVGPSSVVCLPNGTW--T 128
R GP+ S PA P S + C PG + PS C + + +
Sbjct: 521 RPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQ-VCGPGRCISRPSGYTCACDSGFRLS 579
Query: 129 GEQPHCRGISECSS--QPCQNGGTCVEGVNQYRCICPPG-RTGNRCQHQAQTDVNECELY 185
+ C + EC PC G C +RC+C PG R G R DV+EC
Sbjct: 580 PQGTRCIDVDECRRVPPPCAPG-RCENSPGSFRCVCGPGFRAGPRAAECL--DVDECHRV 636
Query: 186 GQEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTG 245
P + C NTPGS+ C CP GY+ G SC+DVDEC +C +G C N
Sbjct: 637 P----PPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRG-ACKNLP 691
Query: 246 GSFQCVSPECPEGSGNVSYVKTSPFQCERNPCPMDSRPC 284
GSF+CV P GS V +C + P P C
Sbjct: 692 GSFRCVCPAGFRGSACEEDVD----ECAQEPPPCGPGRC 726
Score = 82.8 bits (203), Expect = 5e-16
Identities = 70/239 (29%), Positives = 88/239 (36%), Gaps = 69/239 (28%)
Query: 70 GRVGPDALPVSCPALNTPADGR---KFGSKYLVDHEVHFTCNPGFRLVGPSSVVCLPNGT 126
G P P C +N +G G D TC PG+R GP CL
Sbjct: 865 GYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYR-PGPRGASCLD--- 920
Query: 127 WTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPPG-RTG----------------- 168
+ ECS + G C + CICPPG R G
Sbjct: 921 ----------VDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGP 970
Query: 169 -----NRCQHQAQT--------------------DVNECELYGQEGRPRLC-MHACVNTP 202
RC++ + DV+EC+ YG P +C C NTP
Sbjct: 971 ALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYG----PEICGAQRCENTP 1026
Query: 203 GSYRCT--CPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEGS 259
GSYRCT C GY+ G C+DVDEC + C C N GSFQC+ + EG+
Sbjct: 1027 GSYRCTPACDPGYQPTPGG-GCQDVDECRN-RSFCGAHAVCQNLPGSFQCLCDQGYEGA 1083
Score = 81.6 bits (200), Expect = 1e-15
Identities = 56/157 (35%), Positives = 73/157 (46%), Gaps = 40/157 (25%)
Query: 104 HFTCNPGFRLVGPSSVVCLPNGTWTGEQPHCRGISECS-SQPCQNGGTCVEGVNQYRCIC 162
H C GFR GP + C+ + EC+ S P G C ++C+C
Sbjct: 734 HCACPAGFRSRGPGAP--------------CQDVDECARSPPPCTYGRCENTEGSFQCVC 779
Query: 163 P----PGRTGNRCQHQAQTDVNECELY----GQEGRPRLCMHACVNTPGSYRC-TCPGGY 213
P P G+ C+ DV+ECE + GQE CVN+PGS++C TCP G+
Sbjct: 780 PMGFQPNTAGSECE-----DVDECENHLACPGQE---------CVNSPGSFQCRTCPSGH 825
Query: 214 RTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQC 250
L G+ C DVDEC P C C NT GSF+C
Sbjct: 826 H-LHRGR-CTDVDECSSGAPPCGPHGHCTNTEGSFRC 860
Score = 78.2 bits (191), Expect = 1e-14
Identities = 56/153 (36%), Positives = 66/153 (43%), Gaps = 22/153 (14%)
Query: 116 PSSVVCLPN---GTWTGEQPHCRGISECSSQPCQNGGT--CVEGVNQYRCI--CPPG--- 165
P S C+ + G G + C + EC + G C YRC C PG
Sbjct: 982 PGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQP 1041
Query: 166 RTGNRCQHQAQTDVNECELYGQEGRPRLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCED 224
G CQ DV+EC R HA C N PGS++C C GY DG+ C D
Sbjct: 1042 TPGGGCQ-----DVDECR-----NRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVD 1091
Query: 225 VDECVGLQPVCPQGTTCINTGGSFQCVSPECPE 257
V+EC LQ VC C N GSF CV P PE
Sbjct: 1092 VNECETLQGVC-GAALCENVEGSFLCVCPNSPE 1123
Score = 73.6 bits (179), Expect = 3e-13
Identities = 63/199 (31%), Positives = 75/199 (37%), Gaps = 45/199 (22%)
Query: 102 EVHFTCNPGFRLVG-PSSVVC--LPNGTWTGEQPHCRGISECSS--QPCQNGGTCVEGVN 156
E H C PG V P S C P+G + C + ECSS PC G C
Sbjct: 799 ENHLAC-PGQECVNSPGSFQCRTCPSGHHL-HRGRCTDVDECSSGAPPCGPHGHCTNTEG 856
Query: 157 QYRCICPPGRTGNRCQHQAQTDVNEC----------ELYGQEGR------------PR-- 192
+RC C PG + DVNEC E +G PR
Sbjct: 857 SFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGA 916
Query: 193 ------------LCMHA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGT 239
LC C NT GS+ C CP G+R D SC DVDEC P
Sbjct: 917 SCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQ 976
Query: 240 TCINTGGSFQCVSPECPEG 258
C N+ GS++CV +C G
Sbjct: 977 RCENSPGSYRCVR-DCDPG 994
Score = 69.7 bits (169), Expect = 4e-12
Identities = 43/120 (35%), Positives = 56/120 (46%), Gaps = 11/120 (9%)
Query: 134 CRGISECSSQPCQNGGTCVEGVNQYRC-ICPPGRTGNRCQHQAQTDVNECELYGQEGRPR 192
C + EC + G CV ++C CP +G+ TDV+EC G P
Sbjct: 792 CEDVDECENHLACPGQECVNSPGSFQCRTCP---SGHHLHRGRCTDVDECS----SGAPP 844
Query: 193 LCMHA-CVNTPGSYRCTCPGGYRTLADGKS-CEDVDECVGLQPVCPQGTTCINTGGSFQC 250
H C NT GS+RC+C GYR + C DV+EC+ P G C+NT GSF C
Sbjct: 845 CGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHG-ECLNTDGSFAC 903
Score = 65.9 bits (159), Expect = 6e-11
Identities = 40/116 (34%), Positives = 53/116 (45%), Gaps = 13/116 (11%)
Query: 138 SECSSQPCQNGGTCVEGVNQYRCICPPGR--TGNRCQHQAQTDVNECELYGQEGRPRLCM 195
S C Q C T +Y+ +CP GR + DV+EC+L+ R ++C
Sbjct: 1216 SGCRIQQCPGTETA-----EYQSLCPHGRGYLAPSGDLSLRRDVDECQLF----RDQVCK 1266
Query: 196 HA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQC 250
CVNT Y C C GY C D DEC +P C +G C+NT GS+ C
Sbjct: 1267 SGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPAC-EGGRCVNTVGSYHC 1321
Score = 45.8 bits (107), Expect = 7e-05
Identities = 21/57 (36%), Positives = 29/57 (50%), Gaps = 4/57 (7%)
Query: 198 CVNTPGSYRCTCPGGYRTLADGKSCEDVDEC---VGLQPVCPQGTTCINTGGSFQCV 251
CV P + C C GYR +C D++EC P+C C+NT GSF+C+
Sbjct: 1548 CVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLC-VNARCLNTDGSFRCI 1603
Score = 42.0 bits (97), Expect = 0.001
Identities = 26/76 (34%), Positives = 36/76 (47%), Gaps = 4/76 (5%)
Query: 139 ECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMHA- 197
EC G CV + C C G + + A D+NEC+ E LC++A
Sbjct: 1536 ECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTR-MACVDINECD--EAEAASPLCVNAR 1592
Query: 198 CVNTPGSYRCTCPGGY 213
C+NT GS+RC C G+
Sbjct: 1593 CLNTDGSFRCICRPGF 1608
Score = 40.4 bits (93), Expect = 0.003
Identities = 43/137 (31%), Positives = 55/137 (40%), Gaps = 22/137 (16%)
Query: 149 GTCVEGVNQYRCICP-PG-RTGNRCQHQAQT--DVNECELYGQEGRPRLCMHACVNTPGS 204
G C + C P PG RT C A V++C+L + RL V+ P
Sbjct: 287 GYCFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSE----RLGNSERVSAPDG 342
Query: 205 YRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEG----SG 260
CP G+ + SCEDVDEC C G C NT G + CV CP+G S
Sbjct: 343 ---PCPTGFERV--NGSCEDVDEC-ATGGRCQHG-ECANTRGGYTCV---CPDGFLLDSS 392
Query: 261 NVSYVKTSPFQCERNPC 277
S + + PC
Sbjct: 393 RSSCISQHVISEAKGPC 409
Score = 33.9 bits (76), Expect = 0.26
Identities = 24/84 (28%), Positives = 37/84 (44%), Gaps = 8/84 (9%)
Query: 134 CRGISECSSQ-PCQNGGTCVEGVNQYRCICPP----GRTGNRC-QHQAQT-DVNECELYG 186
C EC+ + P GG CV V Y C C P + RC +++Q+ D N +
Sbjct: 1294 CIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQ 1353
Query: 187 QEGRPRLCMHACVNTPGSY-RCTC 209
+ G +C H ++ +Y C C
Sbjct: 1354 EVGADLVCSHPRLDRQATYTECCC 1377
Score = 33.5 bits (75), Expect = 0.34
Identities = 14/28 (50%), Positives = 16/28 (57%), Gaps = 3/28 (10%)
Query: 145 CQNGGTCVEGVNQYRCICPPGRTGNRCQ 172
C NGG CV+ RC+CPP G CQ
Sbjct: 157 CHNGGVCVK---PDRCLCPPDFAGKFCQ 181
>gi|148833508 notch1 preproprotein [Homo sapiens]
Length = 2555
Score = 99.0 bits (245), Expect = 7e-21
Identities = 52/127 (40%), Positives = 69/127 (54%), Gaps = 18/127 (14%)
Query: 133 HCRGIS-ECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRP 191
HC + +C+ C NGGTCV+G+N + C+CPPG TG+ CQH DVNEC + +P
Sbjct: 979 HCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQH----DVNEC-----DSQP 1029
Query: 192 RLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCV 251
L C + GSYRCTCP GY G +C+++ P C G C T ++C
Sbjct: 1030 CLHGGTCQDGCGSYRCTCPQGY----TGPNCQNLVHWCDSSP-CKNGGKCWQTHTQYRC- 1083
Query: 252 SPECPEG 258
ECP G
Sbjct: 1084 --ECPSG 1088
Score = 95.5 bits (236), Expect = 7e-20
Identities = 60/161 (37%), Positives = 79/161 (49%), Gaps = 28/161 (17%)
Query: 121 CLPNGTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVN 180
CLP +TG+ I +C C+NGG CV+GVN Y C CPP TG C DV+
Sbjct: 245 CLPG--FTGQNCE-ENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTE----DVD 297
Query: 181 ECELYGQEGRPRLCMH--ACVNTPGSYRCTCPGGYRTLADGKSC-EDVDECVGLQPVCPQ 237
EC+L P C + C NT G Y C C G+ G+ C E++D+C C
Sbjct: 298 ECQL-----MPNACQNGGTCHNTHGGYNCVCVNGW----TGEDCSENIDDCA--SAACFH 346
Query: 238 GTTCINTGGSFQCVSPECPEG-SGNVSYVKTSPFQCERNPC 277
G TC + SF C ECP G +G + ++ + C NPC
Sbjct: 347 GATCHDRVASFYC---ECPHGRTGLLCHLNDA---CISNPC 381
Score = 84.0 bits (206), Expect = 2e-16
Identities = 66/192 (34%), Positives = 86/192 (44%), Gaps = 29/192 (15%)
Query: 106 TCNPGFRLVGPSSVVCLPNGTWTGEQPHCRGISE-CSSQPCQNGGTCVEGVNQYRCICPP 164
TC G G C P G +TG P+C+ + C S PC+NGG C + QYRC CP
Sbjct: 1035 TCQDG---CGSYRCTC-PQG-YTG--PNCQNLVHWCDSSPCKNGGKCWQTHTQYRCECPS 1087
Query: 165 GRTGNRCQHQAQTDVNECELYGQE---GRPRLCMHA--CVNTPGSYRCTCPGGYRTLADG 219
G TG C + + CE+ Q RLC H CV+ ++ C C GY G
Sbjct: 1088 GWTGLYCDVPSVS----CEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGY----TG 1139
Query: 220 KSCED-VDECVGLQPVCPQGTTCINTGGSFQCVSPECPEGSGNVSYVKTSPFQCERNPCP 278
CED VDEC C G TC + G + C +C G V+ + +C +PC
Sbjct: 1140 SYCEDLVDEC--SPSPCQNGATCTDYLGGYSC---KCVAGYHGVNCSEEID-ECLSHPC- 1192
Query: 279 MDSRPCRHLPKT 290
+ C LP T
Sbjct: 1193 QNGGTCLDLPNT 1204
Score = 82.0 bits (201), Expect = 8e-16
Identities = 56/175 (32%), Positives = 80/175 (45%), Gaps = 33/175 (18%)
Query: 114 VGPSSVVCLPNGTWTGEQPHCR-GISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQ 172
+G +C+P E HC EC+S PC + G C++ +N+++C CP G TG+ CQ
Sbjct: 471 IGEFQCICMPGY----EGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQ 526
Query: 173 HQAQTDVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCE-DVDECVGL 231
+ DV+EC P C++ P +Y C C GY G CE D+DEC
Sbjct: 527 Y----DVDECA-----STPCKNGAKCLDGPNTYTCVCTEGYT----GTHCEVDIDECD-- 571
Query: 232 QPVCPQGTTCINTGGSFQCVSPECPEGSGNVSYVKTSPFQCERNPCPMDSRPCRH 286
C G+ C + +F C+ C G + CE N S+PCRH
Sbjct: 572 PDPCHYGS-CKDGVATFTCL---CRPGY--------TGHHCETNINECSSQPCRH 614
Score = 80.9 bits (198), Expect = 2e-15
Identities = 52/135 (38%), Positives = 63/135 (46%), Gaps = 20/135 (14%)
Query: 121 CLPNGTWTGEQPHC-RGISECSSQPCQNGGTC-VEGVNQYRCICPPGRTGNRCQHQA-QT 177
C+ T TG P+C R CS PCQNGGTC G + C C PG TG C+
Sbjct: 204 CVCRATHTG--PNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDC 261
Query: 178 DVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSC-EDVDECVGLQPVCP 236
N C+ G ACV+ +Y C CP + G+ C EDVDEC + C
Sbjct: 262 PGNNCKNGG----------ACVDGVNTYNCRCPPEW----TGQYCTEDVDECQLMPNACQ 307
Query: 237 QGTTCINTGGSFQCV 251
G TC NT G + CV
Sbjct: 308 NGGTCHNTHGGYNCV 322
Score = 79.3 bits (194), Expect = 5e-15
Identities = 45/148 (30%), Positives = 72/148 (48%), Gaps = 21/148 (14%)
Query: 132 PHCR-GISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGR 190
P C ++EC S PCQN TC++ + +++CIC PG G C + + +EC
Sbjct: 447 PRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHC----EVNTDEC-----ASS 497
Query: 191 PRLCMHACVNTPGSYRCTCPGGYRTLADGKSCE-DVDECVGLQPVCPQGTTCINTGGSFQ 249
P L C++ ++C CP G+ G C+ DVDEC C G C++ ++
Sbjct: 498 PCLHNGRCLDKINEFQCECPTGF----TGHLCQYDVDECASTP--CKNGAKCLDGPNTYT 551
Query: 250 CVSPECPEGSGNVSYVKTSPFQCERNPC 277
CV C EG ++ + +C+ +PC
Sbjct: 552 CV---CTEGYTG-THCEVDIDECDPDPC 575
Score = 79.3 bits (194), Expect = 5e-15
Identities = 48/142 (33%), Positives = 65/142 (45%), Gaps = 20/142 (14%)
Query: 137 ISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMH 196
I +C PC NGG+C +G+N C C PG G C+ D+NEC P
Sbjct: 908 IDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEE----DINEC-----ASDPCRNGA 958
Query: 197 ACVNTPGSYRCTCPGGYRTLADGKSCE-DVDECVGLQPVCPQGTTCINTGGSFQCVSPEC 255
C + SY CTCP G+ G CE + +C + C G TC++ SF C+ C
Sbjct: 959 NCTDCVDSYTCTCPAGF----SGIHCENNTPDCT--ESSCFNGGTCVDGINSFTCL---C 1009
Query: 256 PEGSGNVSYVKTSPFQCERNPC 277
P G SY + +C+ PC
Sbjct: 1010 PPGFTG-SYCQHDVNECDSQPC 1030
Score = 79.0 bits (193), Expect = 7e-15
Identities = 49/127 (38%), Positives = 64/127 (50%), Gaps = 17/127 (13%)
Query: 137 ISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECE-LYGQEGRPRLCM 195
I EC S PCQNGGTC++ N Y+C CP G G C + +V++C R C
Sbjct: 1184 IDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHC----EINVDDCNPPVDPVSRSPKCF 1239
Query: 196 H--ACVNTPGSYRCTCPGGYRTLADGKSCE-DVDECVGLQPVCPQGT-TCINTGGSFQCV 251
+ CV+ G Y CTCP G+ G+ CE DV+EC+ P +GT C+ F C
Sbjct: 1240 NNGTCVDQVGGYSCTCPPGF----VGERCEGDVNECLS-NPCDARGTQNCVQRVNDFHC- 1293
Query: 252 SPECPEG 258
EC G
Sbjct: 1294 --ECRAG 1298
Score = 74.7 bits (182), Expect = 1e-13
Identities = 66/204 (32%), Positives = 83/204 (40%), Gaps = 52/204 (25%)
Query: 82 PALNTPADGRKFGSKYLVDHE--VHFTCNPGFRLVGPSSVV-----CLPN-----GT--- 126
P L+TP + G+ ++VD + C+ GP + CL N GT
Sbjct: 62 PCLSTPC--KNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDL 119
Query: 127 -------------WTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQH 173
W+G+ C+ C+S PC NGG C+ Y C CPP G C+
Sbjct: 120 LTLTEYKCRCPPGWSGKS--CQQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQ 177
Query: 174 QAQTDVNECELYGQEGRPRLCMH--ACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGL 231
DVNEC GQ +P LC H C N GSYRC C R G +CE
Sbjct: 178 ----DVNEC---GQ--KPGLCRHGGTCHNEVGSYRCVC----RATHTGPNCERPYVPCSP 224
Query: 232 QPVCPQGTTCINTGGSFQCVSPEC 255
P C G TC TG V+ EC
Sbjct: 225 SP-CQNGGTCRPTGD----VTHEC 243
Score = 74.3 bits (181), Expect = 2e-13
Identities = 49/150 (32%), Positives = 72/150 (48%), Gaps = 30/150 (20%)
Query: 137 ISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMH 196
+ EC+S PC+NG C++G N Y C+C G TG C + D++EC+ P C +
Sbjct: 529 VDECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHC----EVDIDECD-------PDPCHY 577
Query: 197 -ACVNTPGSYRCTCPGGYRTLADGKSCE-DVDECVGLQPVCPQGTTCINTGGSFQCVSPE 254
+C + ++ C C GY G CE +++EC QP C G TC + ++ C
Sbjct: 578 GSCKDGVATFTCLCRPGY----TGHHCETNINEC-SSQP-CRHGGTCQDRDNAYLCF--- 628
Query: 255 CPEGSGNVSYVKTSPFQCERNPCPMDSRPC 284
C +G+ T P CE N S PC
Sbjct: 629 CLKGT-------TGP-NCEINLDDCASSPC 650
Score = 73.9 bits (180), Expect = 2e-13
Identities = 52/173 (30%), Positives = 76/173 (43%), Gaps = 24/173 (13%)
Query: 107 CNPGFRLVGPSSVVCLPNGTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPPGR 166
C+ G L C +TG + I EC+ PC NGGTC +G+N + C CP G
Sbjct: 650 CDSGTCLDKIDGYECACEPGYTGSMCNIN-IDECAGNPCHNGGTCEDGINGFTCRCPEGY 708
Query: 167 TGNRCQHQAQTDVNECELYGQEGRPRLCMH-ACVNTPGSYRCTCPGGYRTLADGKSCE-D 224
C ++VNEC C+H AC ++ Y+C C G+ G +C+ +
Sbjct: 709 HDPTC----LSEVNEC-------NSNPCVHGACRDSLNGYKCDCDPGW----SGTNCDIN 753
Query: 225 VDECVGLQPVCPQGTTCINTGGSFQCVSPECPEGSGNVSYVKTSPFQCERNPC 277
+EC C G TC + + C C EG + +T+ +C NPC
Sbjct: 754 NNECE--SNPCVNGGTCKDMTSGYVCT---CREGFSGPN-CQTNINECASNPC 800
Score = 73.9 bits (180), Expect = 2e-13
Identities = 55/164 (33%), Positives = 80/164 (48%), Gaps = 23/164 (14%)
Query: 117 SSVVCLPNGTWTGEQPHCR-GISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQ-HQ 174
S VC ++G P+C+ I+EC+S PC N GTC++ V Y+C C TG C+
Sbjct: 773 SGYVCTCREGFSG--PNCQTNINECASNPCLNQGTCIDDVAGYKCNCLLPYTGATCEVVL 830
Query: 175 AQTDVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCE-DVDECVGLQP 233
A + C G+ C + S+ C CP G++ G++CE D++ECV L P
Sbjct: 831 APCAPSPCRNGGE------CRQS--EDYESFSCVCPTGWQ----GQTCEVDINECV-LSP 877
Query: 234 VCPQGTTCINTGGSFQCVSPECPEGSGNVSYVKTSPFQCERNPC 277
C G +C NT G ++C C G + +T C NPC
Sbjct: 878 -CRHGASCQNTHGGYRC---HCQAGYSGRN-CETDIDDCRPNPC 916
Score = 72.0 bits (175), Expect = 9e-13
Identities = 60/203 (29%), Positives = 89/203 (43%), Gaps = 33/203 (16%)
Query: 97 YLVDHEVHFTCNPGFRL----VGPSSVVCLPNGTWTGEQPHC-RGISECS--SQPCQNGG 149
+L D + CN G V ++ P+G +TG P C + + ECS + PC++ G
Sbjct: 371 HLNDACISNPCNEGSNCDTNPVNGKAICTCPSG-YTG--PACSQDVDECSLGANPCEHAG 427
Query: 150 TCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMHACVNTPGSYRCTC 209
C+ + + C C G TG RC + DVNEC P C++ G ++C C
Sbjct: 428 KCINTLGSFECQCLQGYTGPRC----EIDVNEC-----VSNPCQNDATCLDQIGEFQCIC 478
Query: 210 PGGYRTLADGKSCE-DVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEG-SGNVSYVKT 267
GY +G CE + DEC C C++ FQC ECP G +G++
Sbjct: 479 MPGY----EGVHCEVNTDECA--SSPCLHNGRCLDKINEFQC---ECPTGFTGHLCQYDV 529
Query: 268 SPFQCERNPCPMDSRPCRHLPKT 290
+C PC ++ C P T
Sbjct: 530 D--ECASTPCKNGAK-CLDGPNT 549
Score = 70.1 bits (170), Expect = 3e-12
Identities = 54/211 (25%), Positives = 74/211 (35%), Gaps = 72/211 (34%)
Query: 121 CLPNGTWTGEQPHCRGISECSSQPCQNGGTC----------------------------- 151
C+ G + G P C+ + C S PC+N GTC
Sbjct: 46 CVCGGAFVG--PRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLD 103
Query: 152 ---------------VEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMH 196
+ + +Y+C CPPG +G CQ N C GQ
Sbjct: 104 NACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQ--------- 154
Query: 197 ACVNTPGSYRCTCPGGYRTLADGKSC-EDVDECVGLQPVCPQGTTCINTGGSFQCVSPEC 255
C+ SY C CP + G +C +DV+EC +C G TC N GS++CV
Sbjct: 155 -CLPFEASYICHCPPSFH----GPTCRQDVNECGQKPGLCRHGGTCHNEVGSYRCVCRAT 209
Query: 256 PEGSGNVSYVKTSPFQCERNPCPMDSRPCRH 286
G CER P PC++
Sbjct: 210 HTGP-----------NCERPYVPCSPSPCQN 229
Score = 68.9 bits (167), Expect = 7e-12
Identities = 54/155 (34%), Positives = 70/155 (45%), Gaps = 32/155 (20%)
Query: 114 VGPSSVVCLPNGTWTGEQPHCRG-ISECSSQPCQNGGT--CVEGVNQYRCICPPGRTGNR 170
VG S C P + GE+ C G ++EC S PC GT CV+ VN + C C G TG R
Sbjct: 1248 VGGYSCTCPPG--FVGER--CEGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRR 1303
Query: 171 CQHQAQTDVNECELYGQEGRPRLCMHACV---NTPGSYRCTCPGGYRTLADGKSCE-DVD 226
C E + G +G+P C NT + C CP G+ +G +CE D
Sbjct: 1304 C---------ESVINGCKGKPCKNGGTCAVASNTARGFICKCPAGF----EGATCENDAR 1350
Query: 227 ECVGLQPVCPQGTTCINTGGSFQCV------SPEC 255
C L+ C G TCI+ S C+ PEC
Sbjct: 1351 TCGSLR--CLNGGTCISGPRSPTCLCLGPFTGPEC 1383
Score = 65.1 bits (157), Expect = 1e-10
Identities = 45/148 (30%), Positives = 70/148 (47%), Gaps = 23/148 (15%)
Query: 132 PHCR-GISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGR 190
P+C + +C+S PC + GTC++ ++ Y C C PG TG+ C +++EC G
Sbjct: 636 PNCEINLDDCASSPC-DSGTCLDKIDGYECACEPGYTGSMC----NINIDEC-----AGN 685
Query: 191 PRLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQC 250
P C + + C CP GY D +V+EC P C G C ++ ++C
Sbjct: 686 PCHNGGTCEDGINGFTCRCPEGYH---DPTCLSEVNEC-NSNP-CVHG-ACRDSLNGYKC 739
Query: 251 VSPECPEG-SGNVSYVKTSPFQCERNPC 277
+C G SG + + +CE NPC
Sbjct: 740 ---DCDPGWSGTNCDINNN--ECESNPC 762
Score = 57.4 bits (137), Expect = 2e-08
Identities = 44/173 (25%), Positives = 63/173 (36%), Gaps = 42/173 (24%)
Query: 137 ISECSSQPCQNGGTC--VEGVNQYRCICPPG---------------------------RT 167
++ C+ PC+NGG C E + C+CP G
Sbjct: 830 LAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHG 889
Query: 168 GNRCQHQAQTDVNECELYGQEGRPRLCMH--ACVNTPGSYRCTCPGGYRTLADGKSC-ED 224
G RC QA CE + RP C + +C + + C C G+R G C ED
Sbjct: 890 GYRCHCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFR----GTFCEED 945
Query: 225 VDECVGLQPVCPQGTTCINTGGSFQCVSPECPEGSGNVSYVKTSPFQCERNPC 277
++EC C G C + S+ C CP G + +P C + C
Sbjct: 946 INECA--SDPCRNGANCTDCVDSYTCT---CPAGFSGIHCENNTP-DCTESSC 992
Score = 55.8 bits (133), Expect = 6e-08
Identities = 44/147 (29%), Positives = 52/147 (35%), Gaps = 21/147 (14%)
Query: 140 CSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMHACV 199
C S C NGGTC+ G C+C TG CQ A + G P C
Sbjct: 1352 CGSLRCLNGGTCISGPRSPTCLCLGPFTGPECQFPASSPC-------LGGNPCYNQGTCE 1404
Query: 200 NTPGS--YRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPE 257
T S YRC CP + +G C +D G I C PEC E
Sbjct: 1405 PTSESPFYRCLCPAKF----NGLLCHILDYSFGGGAGRDIPPPLIEEA----CELPECQE 1456
Query: 258 GSGNVSYVKTSPFQCERNPCPMDSRPC 284
+GN K QC + C D C
Sbjct: 1457 DAGN----KVCSLQCNNHACGWDGGDC 1479
Score = 43.9 bits (102), Expect = 3e-04
Identities = 38/149 (25%), Positives = 50/149 (33%), Gaps = 43/149 (28%)
Query: 142 SQP---CQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQ------TDVNECELYGQEG--- 189
SQP C NGG C C+C G RCQ + C + + G
Sbjct: 25 SQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGVAD 84
Query: 190 ---------RPRLCM----HACVNTP------------GSYRCTCPGGYRTLADGKSCED 224
LC+ +AC+ P Y+C CP G+ GKSC+
Sbjct: 85 YACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGW----SGKSCQQ 140
Query: 225 VDECVGLQPVCPQGTTCINTGGSFQCVSP 253
D C C G C+ S+ C P
Sbjct: 141 ADPCA--SNPCANGGQCLPFEASYICHCP 167
Score = 42.0 bits (97), Expect = 0.001
Identities = 26/68 (38%), Positives = 32/68 (47%), Gaps = 5/68 (7%)
Query: 108 NPGFRLVGPSSVVCLPNGTWTGEQPHCRGISEC-SSQPCQNGGTCVEGVNQ---YRCICP 163
N G + GP S CL G +TG + S C PC N GTC E ++ YRC+CP
Sbjct: 1359 NGGTCISGPRSPTCLCLGPFTGPECQFPASSPCLGGNPCYNQGTC-EPTSESPFYRCLCP 1417
Query: 164 PGRTGNRC 171
G C
Sbjct: 1418 AKFNGLLC 1425
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 98.2 bits (243), Expect = 1e-20
Identities = 60/161 (37%), Positives = 78/161 (48%), Gaps = 18/161 (11%)
Query: 159 RCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLAD 218
R CPPG Q+ TD++EC + LC HAC NT GSY+C CP GYR L
Sbjct: 3662 RAWCPPGFIR---QNGVCTDLDECRVRN------LCQHACRNTEGSYQCLCPAGYRLLPS 3712
Query: 219 GKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEGSGNVSYVK-TSPFQCERNPC 277
GK+C+D++EC C G C NT GS+QCV CP +Y + SP C R C
Sbjct: 3713 GKNCQDINECEEESIECGPGQMCFNTRGSYQCVDTPCP-----ATYRQGPSPGTCFRR-C 3766
Query: 278 PMDSRPCRHLPKTISFHYLSLPSNLKTPITLFRMATASAPG 318
D P T+ + L LP ++ + R+ S G
Sbjct: 3767 SQDCGTGG--PSTLQYRLLPLPLGVRAHHDVARLTAFSEVG 3805
Score = 78.6 bits (192), Expect = 9e-15
Identities = 53/153 (34%), Positives = 72/153 (47%), Gaps = 24/153 (15%)
Query: 115 GPSSVVCLPNGTWTGEQPHCRGISECS--SQPCQNGGTCVEGVNQYRCI--CPPG---RT 167
G S C + +CR + EC+ + C+ G CV + YRC+ C PG
Sbjct: 3463 GRFSCTCPTGFALAWDDRNCRDVDECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRVAD 3522
Query: 168 GNRCQHQAQTDVNECELYGQEGRPRLCMH--ACVNTPGSYRCTCPGGYRTLADGKSCEDV 225
G C+ DV+EC L G + C + C NTPG +RC+CP GYR C DV
Sbjct: 3523 GAGCE-----DVDEC-LEGLDD----CHYNQLCENTPGGHRCSCPRGYRMQGPSLPCLDV 3572
Query: 226 DECVGLQPVCPQGTTCINTGGSFQCVSPECPEG 258
+EC+ L C C N GS++C+ CP G
Sbjct: 3573 NECLQLPKAC--AYQCHNLQGSYRCL---CPPG 3600
Score = 77.0 bits (188), Expect = 3e-14
Identities = 34/81 (41%), Positives = 47/81 (58%), Gaps = 6/81 (7%)
Query: 178 DVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQ 237
D +EC G P C HAC+N PG + CTCP G+ D ++C DVDEC +C +
Sbjct: 3443 DRDECS-----GGPSPCSHACLNAPGRFSCTCPTGFALAWDDRNCRDVDECAWDAHLCRE 3497
Query: 238 GTTCINTGGSFQCVSPECPEG 258
G C+N GS++C+ P+C G
Sbjct: 3498 GQRCVNLLGSYRCL-PDCGPG 3517
Score = 72.0 bits (175), Expect = 9e-13
Identities = 57/178 (32%), Positives = 72/178 (40%), Gaps = 32/178 (17%)
Query: 134 CRGISECSSQPCQNGGTCVEGVNQYRCICPPGRT----GNRCQHQAQTDVNECELYGQEG 189
C ECS P C+ ++ C CP G C+ DV+EC
Sbjct: 3441 CVDRDECSGGPSPCSHACLNAPGRFSCTCPTGFALAWDDRNCR-----DVDEC-----AW 3490
Query: 190 RPRLCMHA--CVNTPGSYRC--TCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTG 245
LC CVN GSYRC C G+R +ADG CEDVDEC+ C C NT
Sbjct: 3491 DAHLCREGQRCVNLLGSYRCLPDCGPGFR-VADGAGCEDVDECLEGLDDCHYNQLCENTP 3549
Query: 246 GSFQCVSPECPEGSGNVSYVKTSPFQCERNPCPMDSRPCRHLPKTISFHYLSLPSNLK 303
G +C CP G Y P PC +D C LPK ++ +L + +
Sbjct: 3550 GGHRC---SCPRG-----YRMQGP----SLPC-LDVNECLQLPKACAYQCHNLQGSYR 3594
Score = 61.2 bits (147), Expect = 2e-09
Identities = 43/128 (33%), Positives = 53/128 (41%), Gaps = 16/128 (12%)
Query: 107 CNPGFRLVGP-SSVVCLPN---GTWTGEQPHCRGISECSS--QPCQNGGTCVEGVNQYRC 160
C G R V S CLP+ G + C + EC C C +RC
Sbjct: 3495 CREGQRCVNLLGSYRCLPDCGPGFRVADGAGCEDVDECLEGLDDCHYNQLCENTPGGHRC 3554
Query: 161 ICPPGRTGNRCQHQAQT--DVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLAD 218
CP G R Q + DVNEC P+ C + C N GSYRC CP G L D
Sbjct: 3555 SCP---RGYRMQGPSLPCLDVNECLQL-----PKACAYQCHNLQGSYRCLCPPGQTLLRD 3606
Query: 219 GKSCEDVD 226
GK+C ++
Sbjct: 3607 GKACTSLE 3614
Score = 49.7 bits (117), Expect = 5e-06
Identities = 55/200 (27%), Positives = 77/200 (38%), Gaps = 55/200 (27%)
Query: 134 CRGISECSSQP-CQNGGTCVEGVNQYRCICPPG----RTGNRCQHQAQTDVNECELYGQE 188
C + EC + CQ+ EG Y+C+CP G +G CQ D+NECE E
Sbjct: 3676 CTDLDECRVRNLCQHACRNTEG--SYQCLCPAGYRLLPSGKNCQ-----DINECEEESIE 3728
Query: 189 GRPRLCMHACVNTPGSYRCT---CPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTG 245
P C NT GSY+C CP YR QG + G
Sbjct: 3729 CGPG---QMCFNTRGSYQCVDTPCPATYR----------------------QGP---SPG 3760
Query: 246 GSFQCVSPECPEGSGNVSYVKTSPFQCERNPCPMDSRPCRHLPKTISFHYLSLPSNLKTP 305
F+ S +C G S Q P P+ R + + +F + +P+N +T
Sbjct: 3761 TCFRRCSQDCGTGG-------PSTLQYRLLPLPLGVRAHHDVARLTAFSEVGVPAN-RTE 3812
Query: 306 ITLF----RMATASAPGRAG 321
+++ R A P RAG
Sbjct: 3813 LSMLEPDPRSPFALRPLRAG 3832
Score = 37.4 bits (85), Expect = 0.024
Identities = 19/50 (38%), Positives = 22/50 (44%), Gaps = 5/50 (10%)
Query: 209 CPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEG 258
CP G+ + G C D DEC G C C+N G F C CP G
Sbjct: 3428 CPEGFELDSQGAFCVDRDECSGGPSPCSH--ACLNAPGRFSCT---CPTG 3472
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 98.2 bits (243), Expect = 1e-20
Identities = 60/161 (37%), Positives = 78/161 (48%), Gaps = 18/161 (11%)
Query: 159 RCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLAD 218
R CPPG Q+ TD++EC + LC HAC NT GSY+C CP GYR L
Sbjct: 4853 RAWCPPGFIR---QNGVCTDLDECRVRN------LCQHACRNTEGSYQCLCPAGYRLLPS 4903
Query: 219 GKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEGSGNVSYVK-TSPFQCERNPC 277
GK+C+D++EC C G C NT GS+QCV CP +Y + SP C R C
Sbjct: 4904 GKNCQDINECEEESIECGPGQMCFNTRGSYQCVDTPCP-----ATYRQGPSPGTCFRR-C 4957
Query: 278 PMDSRPCRHLPKTISFHYLSLPSNLKTPITLFRMATASAPG 318
D P T+ + L LP ++ + R+ S G
Sbjct: 4958 SQDCGTGG--PSTLQYRLLPLPLGVRAHHDVARLTAFSEVG 4996
Score = 78.6 bits (192), Expect = 9e-15
Identities = 53/153 (34%), Positives = 72/153 (47%), Gaps = 24/153 (15%)
Query: 115 GPSSVVCLPNGTWTGEQPHCRGISECS--SQPCQNGGTCVEGVNQYRCI--CPPG---RT 167
G S C + +CR + EC+ + C+ G CV + YRC+ C PG
Sbjct: 4654 GRFSCTCPTGFALAWDDRNCRDVDECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRVAD 4713
Query: 168 GNRCQHQAQTDVNECELYGQEGRPRLCMH--ACVNTPGSYRCTCPGGYRTLADGKSCEDV 225
G C+ DV+EC L G + C + C NTPG +RC+CP GYR C DV
Sbjct: 4714 GAGCE-----DVDEC-LEGLDD----CHYNQLCENTPGGHRCSCPRGYRMQGPSLPCLDV 4763
Query: 226 DECVGLQPVCPQGTTCINTGGSFQCVSPECPEG 258
+EC+ L C C N GS++C+ CP G
Sbjct: 4764 NECLQLPKAC--AYQCHNLQGSYRCL---CPPG 4791
Score = 77.0 bits (188), Expect = 3e-14
Identities = 34/81 (41%), Positives = 47/81 (58%), Gaps = 6/81 (7%)
Query: 178 DVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQ 237
D +EC G P C HAC+N PG + CTCP G+ D ++C DVDEC +C +
Sbjct: 4634 DRDECS-----GGPSPCSHACLNAPGRFSCTCPTGFALAWDDRNCRDVDECAWDAHLCRE 4688
Query: 238 GTTCINTGGSFQCVSPECPEG 258
G C+N GS++C+ P+C G
Sbjct: 4689 GQRCVNLLGSYRCL-PDCGPG 4708
Score = 72.0 bits (175), Expect = 9e-13
Identities = 57/178 (32%), Positives = 72/178 (40%), Gaps = 32/178 (17%)
Query: 134 CRGISECSSQPCQNGGTCVEGVNQYRCICPPGRT----GNRCQHQAQTDVNECELYGQEG 189
C ECS P C+ ++ C CP G C+ DV+EC
Sbjct: 4632 CVDRDECSGGPSPCSHACLNAPGRFSCTCPTGFALAWDDRNCR-----DVDEC-----AW 4681
Query: 190 RPRLCMHA--CVNTPGSYRC--TCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTG 245
LC CVN GSYRC C G+R +ADG CEDVDEC+ C C NT
Sbjct: 4682 DAHLCREGQRCVNLLGSYRCLPDCGPGFR-VADGAGCEDVDECLEGLDDCHYNQLCENTP 4740
Query: 246 GSFQCVSPECPEGSGNVSYVKTSPFQCERNPCPMDSRPCRHLPKTISFHYLSLPSNLK 303
G +C CP G Y P PC +D C LPK ++ +L + +
Sbjct: 4741 GGHRC---SCPRG-----YRMQGP----SLPC-LDVNECLQLPKACAYQCHNLQGSYR 4785
Score = 61.2 bits (147), Expect = 2e-09
Identities = 43/128 (33%), Positives = 53/128 (41%), Gaps = 16/128 (12%)
Query: 107 CNPGFRLVGP-SSVVCLPN---GTWTGEQPHCRGISECSS--QPCQNGGTCVEGVNQYRC 160
C G R V S CLP+ G + C + EC C C +RC
Sbjct: 4686 CREGQRCVNLLGSYRCLPDCGPGFRVADGAGCEDVDECLEGLDDCHYNQLCENTPGGHRC 4745
Query: 161 ICPPGRTGNRCQHQAQT--DVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLAD 218
CP G R Q + DVNEC P+ C + C N GSYRC CP G L D
Sbjct: 4746 SCP---RGYRMQGPSLPCLDVNECLQL-----PKACAYQCHNLQGSYRCLCPPGQTLLRD 4797
Query: 219 GKSCEDVD 226
GK+C ++
Sbjct: 4798 GKACTSLE 4805
Score = 49.7 bits (117), Expect = 5e-06
Identities = 55/200 (27%), Positives = 77/200 (38%), Gaps = 55/200 (27%)
Query: 134 CRGISECSSQP-CQNGGTCVEGVNQYRCICPPG----RTGNRCQHQAQTDVNECELYGQE 188
C + EC + CQ+ EG Y+C+CP G +G CQ D+NECE E
Sbjct: 4867 CTDLDECRVRNLCQHACRNTEG--SYQCLCPAGYRLLPSGKNCQ-----DINECEEESIE 4919
Query: 189 GRPRLCMHACVNTPGSYRCT---CPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTG 245
P C NT GSY+C CP YR QG + G
Sbjct: 4920 CGPG---QMCFNTRGSYQCVDTPCPATYR----------------------QGP---SPG 4951
Query: 246 GSFQCVSPECPEGSGNVSYVKTSPFQCERNPCPMDSRPCRHLPKTISFHYLSLPSNLKTP 305
F+ S +C G S Q P P+ R + + +F + +P+N +T
Sbjct: 4952 TCFRRCSQDCGTGG-------PSTLQYRLLPLPLGVRAHHDVARLTAFSEVGVPAN-RTE 5003
Query: 306 ITLF----RMATASAPGRAG 321
+++ R A P RAG
Sbjct: 5004 LSMLEPDPRSPFALRPLRAG 5023
Score = 37.4 bits (85), Expect = 0.024
Identities = 19/50 (38%), Positives = 22/50 (44%), Gaps = 5/50 (10%)
Query: 209 CPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEG 258
CP G+ + G C D DEC G C C+N G F C CP G
Sbjct: 4619 CPEGFELDSQGAFCVDRDECSGGPSPCSH--ACLNAPGRFSCT---CPTG 4663
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 98.2 bits (243), Expect = 1e-20
Identities = 60/161 (37%), Positives = 78/161 (48%), Gaps = 18/161 (11%)
Query: 159 RCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLAD 218
R CPPG Q+ TD++EC + LC HAC NT GSY+C CP GYR L
Sbjct: 3571 RAWCPPGFIR---QNGVCTDLDECRVRN------LCQHACRNTEGSYQCLCPAGYRLLPS 3621
Query: 219 GKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEGSGNVSYVK-TSPFQCERNPC 277
GK+C+D++EC C G C NT GS+QCV CP +Y + SP C R C
Sbjct: 3622 GKNCQDINECEEESIECGPGQMCFNTRGSYQCVDTPCP-----ATYRQGPSPGTCFRR-C 3675
Query: 278 PMDSRPCRHLPKTISFHYLSLPSNLKTPITLFRMATASAPG 318
D P T+ + L LP ++ + R+ S G
Sbjct: 3676 SQDCGTGG--PSTLQYRLLPLPLGVRAHHDVARLTAFSEVG 3714
Score = 78.6 bits (192), Expect = 9e-15
Identities = 53/153 (34%), Positives = 72/153 (47%), Gaps = 24/153 (15%)
Query: 115 GPSSVVCLPNGTWTGEQPHCRGISECS--SQPCQNGGTCVEGVNQYRCI--CPPG---RT 167
G S C + +CR + EC+ + C+ G CV + YRC+ C PG
Sbjct: 3372 GRFSCTCPTGFALAWDDRNCRDVDECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRVAD 3431
Query: 168 GNRCQHQAQTDVNECELYGQEGRPRLCMH--ACVNTPGSYRCTCPGGYRTLADGKSCEDV 225
G C+ DV+EC L G + C + C NTPG +RC+CP GYR C DV
Sbjct: 3432 GAGCE-----DVDEC-LEGLDD----CHYNQLCENTPGGHRCSCPRGYRMQGPSLPCLDV 3481
Query: 226 DECVGLQPVCPQGTTCINTGGSFQCVSPECPEG 258
+EC+ L C C N GS++C+ CP G
Sbjct: 3482 NECLQLPKAC--AYQCHNLQGSYRCL---CPPG 3509
Score = 77.0 bits (188), Expect = 3e-14
Identities = 34/81 (41%), Positives = 47/81 (58%), Gaps = 6/81 (7%)
Query: 178 DVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQ 237
D +EC G P C HAC+N PG + CTCP G+ D ++C DVDEC +C +
Sbjct: 3352 DRDECS-----GGPSPCSHACLNAPGRFSCTCPTGFALAWDDRNCRDVDECAWDAHLCRE 3406
Query: 238 GTTCINTGGSFQCVSPECPEG 258
G C+N GS++C+ P+C G
Sbjct: 3407 GQRCVNLLGSYRCL-PDCGPG 3426
Score = 72.0 bits (175), Expect = 9e-13
Identities = 57/178 (32%), Positives = 72/178 (40%), Gaps = 32/178 (17%)
Query: 134 CRGISECSSQPCQNGGTCVEGVNQYRCICPPGRT----GNRCQHQAQTDVNECELYGQEG 189
C ECS P C+ ++ C CP G C+ DV+EC
Sbjct: 3350 CVDRDECSGGPSPCSHACLNAPGRFSCTCPTGFALAWDDRNCR-----DVDEC-----AW 3399
Query: 190 RPRLCMHA--CVNTPGSYRC--TCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTG 245
LC CVN GSYRC C G+R +ADG CEDVDEC+ C C NT
Sbjct: 3400 DAHLCREGQRCVNLLGSYRCLPDCGPGFR-VADGAGCEDVDECLEGLDDCHYNQLCENTP 3458
Query: 246 GSFQCVSPECPEGSGNVSYVKTSPFQCERNPCPMDSRPCRHLPKTISFHYLSLPSNLK 303
G +C CP G Y P PC +D C LPK ++ +L + +
Sbjct: 3459 GGHRC---SCPRG-----YRMQGP----SLPC-LDVNECLQLPKACAYQCHNLQGSYR 3503
Score = 61.2 bits (147), Expect = 2e-09
Identities = 43/128 (33%), Positives = 53/128 (41%), Gaps = 16/128 (12%)
Query: 107 CNPGFRLVGP-SSVVCLPN---GTWTGEQPHCRGISECSS--QPCQNGGTCVEGVNQYRC 160
C G R V S CLP+ G + C + EC C C +RC
Sbjct: 3404 CREGQRCVNLLGSYRCLPDCGPGFRVADGAGCEDVDECLEGLDDCHYNQLCENTPGGHRC 3463
Query: 161 ICPPGRTGNRCQHQAQT--DVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLAD 218
CP G R Q + DVNEC P+ C + C N GSYRC CP G L D
Sbjct: 3464 SCP---RGYRMQGPSLPCLDVNECLQL-----PKACAYQCHNLQGSYRCLCPPGQTLLRD 3515
Query: 219 GKSCEDVD 226
GK+C ++
Sbjct: 3516 GKACTSLE 3523
Score = 49.7 bits (117), Expect = 5e-06
Identities = 55/200 (27%), Positives = 77/200 (38%), Gaps = 55/200 (27%)
Query: 134 CRGISECSSQP-CQNGGTCVEGVNQYRCICPPG----RTGNRCQHQAQTDVNECELYGQE 188
C + EC + CQ+ EG Y+C+CP G +G CQ D+NECE E
Sbjct: 3585 CTDLDECRVRNLCQHACRNTEG--SYQCLCPAGYRLLPSGKNCQ-----DINECEEESIE 3637
Query: 189 GRPRLCMHACVNTPGSYRCT---CPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTG 245
P C NT GSY+C CP YR QG + G
Sbjct: 3638 CGPG---QMCFNTRGSYQCVDTPCPATYR----------------------QGP---SPG 3669
Query: 246 GSFQCVSPECPEGSGNVSYVKTSPFQCERNPCPMDSRPCRHLPKTISFHYLSLPSNLKTP 305
F+ S +C G S Q P P+ R + + +F + +P+N +T
Sbjct: 3670 TCFRRCSQDCGTGG-------PSTLQYRLLPLPLGVRAHHDVARLTAFSEVGVPAN-RTE 3721
Query: 306 ITLF----RMATASAPGRAG 321
+++ R A P RAG
Sbjct: 3722 LSMLEPDPRSPFALRPLRAG 3741
Score = 37.4 bits (85), Expect = 0.024
Identities = 19/50 (38%), Positives = 22/50 (44%), Gaps = 5/50 (10%)
Query: 209 CPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEG 258
CP G+ + G C D DEC G C C+N G F C CP G
Sbjct: 3337 CPEGFELDSQGAFCVDRDECSGGPSPCSH--ACLNAPGRFSCT---CPTG 3381
>gi|34734068 fibulin 1 isoform A precursor [Homo sapiens]
Length = 566
Score = 98.2 bits (243), Expect = 1e-20
Identities = 47/125 (37%), Positives = 66/125 (52%), Gaps = 6/125 (4%)
Query: 134 CRGISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRL 193
C I+ECSS PC C Y+C C G + D++EC L +
Sbjct: 439 CEDINECSSSPCSQ--ECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECAL---PTGGHI 493
Query: 194 CMHACVNTPGSYRCTCPG-GYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVS 252
C + C+N PGS++C+CP GYR +G++C+D+DECV C TC N G F+C++
Sbjct: 494 CSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLA 553
Query: 253 PECPE 257
ECPE
Sbjct: 554 FECPE 558
Score = 90.5 bits (223), Expect = 2e-18
Identities = 48/123 (39%), Positives = 61/123 (49%), Gaps = 11/123 (8%)
Query: 130 EQPHCRGISECS--SQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQ 187
E C + EC+ ++PC G CV +RC C G + DVNEC+ Y
Sbjct: 350 EGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMC-VDVNECQRYPG 408
Query: 188 EGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGS 247
RLC H C NT GSY C+C G+R DG+SCED++EC P C N GS
Sbjct: 409 ----RLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSS----SPCSQECANVYGS 460
Query: 248 FQC 250
+QC
Sbjct: 461 YQC 463
Score = 69.7 bits (169), Expect = 4e-12
Identities = 51/170 (30%), Positives = 69/170 (40%), Gaps = 21/170 (12%)
Query: 130 EQPHCRGISECSS--QPCQNGGTCVEGVNQYRCI----CPPGRTGNRCQHQAQTDVNECE 183
E C+ I EC S C C + +RC C G + + D+NEC
Sbjct: 256 EDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCI--DINECL 313
Query: 184 LYGQEGRPRLCMHACVNTPGSYRC-----TCPGGYRTLADGKSCEDVDECVGLQPVCPQG 238
P H C+NT GSY C C GY +G C DVDEC C +G
Sbjct: 314 SISA---PCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKG 370
Query: 239 TTCINTGGSFQCVSPECPEG--SGNVSYVKTSPFQCERNPCPMDSRPCRH 286
C+N+ GSF+C EC G +S + +C+R P + C +
Sbjct: 371 HRCVNSPGSFRC---ECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCEN 417
Score = 60.8 bits (146), Expect = 2e-09
Identities = 27/57 (47%), Positives = 35/57 (61%)
Query: 194 CMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQC 250
C C +T C+C GY+ L+DG SCEDV+EC+ C G +CINT GSF+C
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRC 242
Score = 57.8 bits (138), Expect = 2e-08
Identities = 51/161 (31%), Positives = 70/161 (43%), Gaps = 31/161 (19%)
Query: 134 CRGISECSSQPCQNGGTCVEGVNQYRCICPPG----RTGNRCQHQAQTDVNECELYGQEG 189
CRG C Q C++ G ++ C C G G C+ DVNEC
Sbjct: 180 CRGGGPCKQQ-CRDTG------DEVVCSCFVGYQLLSDGVSCE-----DVNECITGSHSC 227
Query: 190 RPRLCMHACVNTPGSYRC----TCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTG 245
R +C+NT GS+RC +C GY L + SC+D+DEC C C NT
Sbjct: 228 R---LGESCINTVGSFRCQRDSSCGTGYE-LTEDNSCKDIDECESGIHNCLPDFICQNTL 283
Query: 246 GSFQC-VSPECPEGSGNVSYVKTSPFQC-ERNPCPMDSRPC 284
GSF+C +C G +++ + C + N C S PC
Sbjct: 284 GSFRCRPKLQCKSG-----FIQDALGNCIDINECLSISAPC 319
>gi|46249414 latent transforming growth factor beta binding protein 1
isoform LTBP-1L [Homo sapiens]
Length = 1722
Score = 97.4 bits (241), Expect = 2e-20
Identities = 59/175 (33%), Positives = 77/175 (44%), Gaps = 23/175 (13%)
Query: 113 LVGPSSVVCLPNGTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQ 172
L G C T T + HCR I EC G C +RC C G + +
Sbjct: 1057 LEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAK 1116
Query: 173 HQAQTDVNECELYGQEGRPRLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGL 231
Q + D++EC+ LC H C NT GS++C C GYR G CED++EC+
Sbjct: 1117 DQCE-DIDECQ------HRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLED 1169
Query: 232 QPVCPQGTTCINTGGSFQCVSPECPEGSGNVSYVKTSPFQCERNPCPMDSRPCRH 286
+ VC +G CINT GS+ C CP+G FQ + N D C H
Sbjct: 1170 KSVCQRG-DCINTAGSYDCT---CPDG-----------FQLDDNKTCQDINECEH 1209
Score = 93.2 bits (230), Expect = 4e-19
Identities = 55/144 (38%), Positives = 67/144 (46%), Gaps = 20/144 (13%)
Query: 115 GPSSVVCLPNGTWTGEQPHCRGISEC--SSQPCQNGGTCVEGVNQYRCICPPG---RTGN 169
G VC +G HC I+EC CQ G C+ Y C CP G
Sbjct: 1141 GSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGD-CINTAGSYDCTCPDGFQLDDNK 1199
Query: 170 RCQHQAQTDVNECELYGQEGRPRLC--MHACVNTPGSYRCTCPGGYRTLADGKSCEDVDE 227
CQ D+NECE P LC C+NT GS+ C C G+ ADG++CED+DE
Sbjct: 1200 TCQ-----DINECE------HPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDE 1248
Query: 228 CVGLQPVCPQGTTCINTGGSFQCV 251
CV VC C NT GSF+C+
Sbjct: 1249 CVN-NTVCDSHGFCDNTAGSFRCL 1271
Score = 82.4 bits (202), Expect = 6e-16
Identities = 59/180 (32%), Positives = 79/180 (43%), Gaps = 17/180 (9%)
Query: 106 TCNPGFRLVGPSSVVCLP-NGTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPP 164
TC + P S C+P + G C + EC G C Y C C
Sbjct: 1008 TCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHK 1067
Query: 165 GRTGNRCQHQAQTDVNECELYGQEGRPRLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCE 223
G T H+ D++EC Q+G LC++ C NT GS+RCTC GY+ A CE
Sbjct: 1068 GYT-RTPDHKHCRDIDEC----QQG--NLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCE 1120
Query: 224 DVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEGSG------NVSYVKTSPFQCERNPC 277
D+DEC + +C G C NT GSFQCV + SG +++ C+R C
Sbjct: 1121 DIDECQH-RHLCAHG-QCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDC 1178
Score = 72.0 bits (175), Expect = 9e-13
Identities = 55/160 (34%), Positives = 74/160 (46%), Gaps = 24/160 (15%)
Query: 137 ISECSSQPCQNG-GTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCM 195
I+EC+ P G G C+ +Y CIC G + Q + D++EC LC
Sbjct: 875 INECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKC-VDIDECTQV-----QHLCS 928
Query: 196 HA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQP-VCPQGTTCINTGGSFQCVSP 253
C NT GS+ C CP G+ +G +C DVDEC L+P VC +G C+NT G+F+C
Sbjct: 929 QGRCENTEGSFLCICPAGFMASEEGTNCIDVDEC--LRPDVCGEG-HCVNTVGAFRC--E 983
Query: 254 ECPEGSGNVSYVKTSPFQCE-----RNPCPMDSRPCRHLP 288
C G Y T +CE NP C + P
Sbjct: 984 YCDSG-----YRMTQRGRCEDIDECLNPSTCPDEQCVNSP 1018
Score = 67.0 bits (162), Expect = 3e-11
Identities = 50/158 (31%), Positives = 67/158 (42%), Gaps = 24/158 (15%)
Query: 130 EQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEG 189
++ C I EC + CV Y+C+ P G R + DV+EC
Sbjct: 993 QRGRCEDIDECLNPSTCPDEQCVNSPGSYQCV--PCTEGFRGWNGQCLDVDECL------ 1044
Query: 190 RPRLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSF 248
P +C + C N GSY C+C GY D K C D+DEC +C G C NT GSF
Sbjct: 1045 EPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDEC-QQGNLCVNG-QCKNTEGSF 1102
Query: 249 QCVSPECPEGSGNVSYVKTSPFQCERNPCPMDSRPCRH 286
+C C +G + + QCE D C+H
Sbjct: 1103 RCT---CGQG----YQLSAAKDQCE------DIDECQH 1127
Score = 65.1 bits (157), Expect = 1e-10
Identities = 34/83 (40%), Positives = 44/83 (53%), Gaps = 10/83 (12%)
Query: 177 TDVNECELYGQEGRPRLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVC 235
T++NEC + P +C C+N P Y C C GYR + C D+DEC +Q +C
Sbjct: 873 TEINECTV-----NPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLC 927
Query: 236 PQGTTCINTGGSFQCVSPECPEG 258
QG C NT GSF C+ CP G
Sbjct: 928 SQG-RCENTEGSFLCI---CPAG 946
Score = 60.5 bits (145), Expect = 3e-09
Identities = 53/158 (33%), Positives = 69/158 (43%), Gaps = 25/158 (15%)
Query: 102 EVHFTCNPGFRLVGPSSVVCL-PNGTWTGEQ-PHCRGISECSSQPCQNGGTCVEGVNQYR 159
+V C+ G S +C+ P G E+ +C + EC G CV V +R
Sbjct: 922 QVQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFR 981
Query: 160 C-ICPPG---RTGNRCQHQAQTDVNECELYGQEGRPRLCM-HACVNTPGSYRCT-CPGGY 213
C C G RC+ D++EC P C CVN+PGSY+C C G+
Sbjct: 982 CEYCDSGYRMTQRGRCE-----DIDECL------NPSTCPDEQCVNSPGSYQCVPCTEGF 1030
Query: 214 RTLADGKSCEDVDECVGLQP-VCPQGTTCINTGGSFQC 250
R C DVDEC L+P VC G C N GS+ C
Sbjct: 1031 R--GWNGQCLDVDEC--LEPNVCANG-DCSNLEGSYMC 1063
Score = 50.4 bits (119), Expect = 3e-06
Identities = 36/114 (31%), Positives = 49/114 (42%), Gaps = 9/114 (7%)
Query: 140 CSSQPCQNGGTC--VEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMHA 197
C PC GT E + + P G + + + D +EC L+GQE +C +
Sbjct: 1385 CEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQE----ICKNG 1440
Query: 198 -CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQC 250
C+NT Y C C G C D+DEC C G C+NT GS+ C
Sbjct: 1441 FCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQD-PSSCIDG-QCVNTEGSYNC 1492
Score = 45.4 bits (106), Expect = 9e-05
Identities = 30/89 (33%), Positives = 41/89 (46%), Gaps = 5/89 (5%)
Query: 145 CQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMHA-CVNTPG 203
C+NG CV Y C C G + + DVNEC+ R LC +A C+NT G
Sbjct: 1632 CENG-RCVRVQEGYTCDCFDGYHLDTAKMTC-VDVNECDELNN--RMSLCKNAKCINTDG 1687
Query: 204 SYRCTCPGGYRTLADGKSCEDVDECVGLQ 232
SY+C C GY C ++ + L+
Sbjct: 1688 SYKCLCLPGYVPSDKPNYCTPLNTALNLE 1716
Score = 45.1 bits (105), Expect = 1e-04
Identities = 30/97 (30%), Positives = 41/97 (42%), Gaps = 8/97 (8%)
Query: 115 GPSSVVCLPNGTWTGEQPHCRGISEC-SSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQH 173
G VC + + + C I EC ++ C + G C +RC+C G +
Sbjct: 1224 GSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQ-DG 1282
Query: 174 QAQTDVNECELYGQEGRPRLCMHA-CVNTPGSYRCTC 209
Q DVNECEL +C A C N GS+ C C
Sbjct: 1283 QGCVDVNECELLSG-----VCGEAFCENVEGSFLCVC 1314
Score = 40.4 bits (93), Expect = 0.003
Identities = 21/57 (36%), Positives = 28/57 (49%), Gaps = 4/57 (7%)
Query: 198 CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQ---PVCPQGTTCINTGGSFQCV 251
CV Y C C GY +C DV+EC L +C + CINT GS++C+
Sbjct: 1637 CVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLC-KNAKCINTDGSYKCL 1692
Score = 40.0 bits (92), Expect = 0.004
Identities = 30/88 (34%), Positives = 40/88 (45%), Gaps = 13/88 (14%)
Query: 136 GISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCM 195
G ++C P + G NQ C PG R + D+NEC+L G +C
Sbjct: 590 GFNKCQKCPKKPS---YHGYNQMM-ECLPGY--KRVNNTFCQDINECQLQG------VCP 637
Query: 196 HA-CVNTPGSYRCTCPGGYRTLADGKSC 222
+ C+NT GSYRCTC G+ SC
Sbjct: 638 NGECLNTMGSYRCTCKIGFGPDPTFSSC 665
Score = 37.0 bits (84), Expect = 0.031
Identities = 17/44 (38%), Positives = 21/44 (47%), Gaps = 3/44 (6%)
Query: 144 PCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQ 187
PCQNGG C+ C+C PG G C+ A D + GQ
Sbjct: 194 PCQNGGMCLR---PQLCVCKPGTKGKACETIAAQDTSSPVFGGQ 234
Score = 37.0 bits (84), Expect = 0.031
Identities = 29/99 (29%), Positives = 42/99 (42%), Gaps = 16/99 (16%)
Query: 145 CQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMHA-CVNTPG 203
C+NG C+ Y C C G + + Q D++EC+ P C+ CVNT G
Sbjct: 1437 CKNG-FCLNTRPGYECYCKQGTYYDPVKLQC-FDMDECQ------DPSSCIDGQCVNTEG 1488
Query: 204 SYRCTC-------PGGYRTLADGKSCEDVDECVGLQPVC 235
SY C C R + +S E ++E Q +C
Sbjct: 1489 SYNCFCTHPMVLDASEKRCIRPAESNEQIEETDVYQDLC 1527
Score = 36.6 bits (83), Expect = 0.040
Identities = 55/209 (26%), Positives = 70/209 (33%), Gaps = 30/209 (14%)
Query: 121 CLPNGTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICP----PGRTGNRCQHQAQ 176
CLP G C+ I+EC Q G C+ + YRC C P T + C
Sbjct: 612 CLP-GYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPP 670
Query: 177 TDVNE-CELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVC 235
E Y R CMH C C G A G CE C
Sbjct: 671 VISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVG---KAWGPHCEK----------C 717
Query: 236 PQGTTCINTGGSFQCVSPECPEGSG-NVSYV-KTSPFQCERNPCPMDSRPCRHLPKTISF 293
P T +F+ + CP G G VS V + P P+ +P P S
Sbjct: 718 PLPGT-----AAFKEI---CPGGMGYTVSGVHRRRPIHHHVGKGPVFVKPKNTQPVAKST 769
Query: 294 HYLSLPSNLKTPITLFRMATASAPGRAGP 322
H LP+ + P+ + PG A P
Sbjct: 770 HPPPLPAK-EEPVEALTFSREHGPGVAEP 797
Score = 33.9 bits (76), Expect = 0.26
Identities = 14/29 (48%), Positives = 17/29 (58%), Gaps = 3/29 (10%)
Query: 144 PCQNGGTCVEGVNQYRCICPPGRTGNRCQ 172
PC NGG C ++ +C CPP TG CQ
Sbjct: 406 PCMNGGQCS---SRDKCQCPPNFTGKLCQ 431
>gi|46249412 latent transforming growth factor beta binding protein
1 isoform LTBP-1S [Homo sapiens]
Length = 1396
Score = 97.4 bits (241), Expect = 2e-20
Identities = 59/175 (33%), Positives = 77/175 (44%), Gaps = 23/175 (13%)
Query: 113 LVGPSSVVCLPNGTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQ 172
L G C T T + HCR I EC G C +RC C G + +
Sbjct: 731 LEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAK 790
Query: 173 HQAQTDVNECELYGQEGRPRLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGL 231
Q + D++EC+ LC H C NT GS++C C GYR G CED++EC+
Sbjct: 791 DQCE-DIDECQ------HRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLED 843
Query: 232 QPVCPQGTTCINTGGSFQCVSPECPEGSGNVSYVKTSPFQCERNPCPMDSRPCRH 286
+ VC +G CINT GS+ C CP+G FQ + N D C H
Sbjct: 844 KSVCQRG-DCINTAGSYDCT---CPDG-----------FQLDDNKTCQDINECEH 883
Score = 93.2 bits (230), Expect = 4e-19
Identities = 55/144 (38%), Positives = 67/144 (46%), Gaps = 20/144 (13%)
Query: 115 GPSSVVCLPNGTWTGEQPHCRGISEC--SSQPCQNGGTCVEGVNQYRCICPPG---RTGN 169
G VC +G HC I+EC CQ G C+ Y C CP G
Sbjct: 815 GSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGD-CINTAGSYDCTCPDGFQLDDNK 873
Query: 170 RCQHQAQTDVNECELYGQEGRPRLC--MHACVNTPGSYRCTCPGGYRTLADGKSCEDVDE 227
CQ D+NECE P LC C+NT GS+ C C G+ ADG++CED+DE
Sbjct: 874 TCQ-----DINECE------HPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDE 922
Query: 228 CVGLQPVCPQGTTCINTGGSFQCV 251
CV VC C NT GSF+C+
Sbjct: 923 CVN-NTVCDSHGFCDNTAGSFRCL 945
Score = 82.4 bits (202), Expect = 6e-16
Identities = 59/180 (32%), Positives = 79/180 (43%), Gaps = 17/180 (9%)
Query: 106 TCNPGFRLVGPSSVVCLP-NGTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPP 164
TC + P S C+P + G C + EC G C Y C C
Sbjct: 682 TCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHK 741
Query: 165 GRTGNRCQHQAQTDVNECELYGQEGRPRLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCE 223
G T H+ D++EC Q+G LC++ C NT GS+RCTC GY+ A CE
Sbjct: 742 GYT-RTPDHKHCRDIDEC----QQG--NLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCE 794
Query: 224 DVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEGSG------NVSYVKTSPFQCERNPC 277
D+DEC + +C G C NT GSFQCV + SG +++ C+R C
Sbjct: 795 DIDECQH-RHLCAHG-QCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDC 852
Score = 72.0 bits (175), Expect = 9e-13
Identities = 55/160 (34%), Positives = 74/160 (46%), Gaps = 24/160 (15%)
Query: 137 ISECSSQPCQNG-GTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCM 195
I+EC+ P G G C+ +Y CIC G + Q + D++EC LC
Sbjct: 549 INECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKC-VDIDECTQV-----QHLCS 602
Query: 196 HA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQP-VCPQGTTCINTGGSFQCVSP 253
C NT GS+ C CP G+ +G +C DVDEC L+P VC +G C+NT G+F+C
Sbjct: 603 QGRCENTEGSFLCICPAGFMASEEGTNCIDVDEC--LRPDVCGEG-HCVNTVGAFRC--E 657
Query: 254 ECPEGSGNVSYVKTSPFQCE-----RNPCPMDSRPCRHLP 288
C G Y T +CE NP C + P
Sbjct: 658 YCDSG-----YRMTQRGRCEDIDECLNPSTCPDEQCVNSP 692
Score = 67.0 bits (162), Expect = 3e-11
Identities = 50/158 (31%), Positives = 67/158 (42%), Gaps = 24/158 (15%)
Query: 130 EQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEG 189
++ C I EC + CV Y+C+ P G R + DV+EC
Sbjct: 667 QRGRCEDIDECLNPSTCPDEQCVNSPGSYQCV--PCTEGFRGWNGQCLDVDECL------ 718
Query: 190 RPRLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSF 248
P +C + C N GSY C+C GY D K C D+DEC +C G C NT GSF
Sbjct: 719 EPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDEC-QQGNLCVNG-QCKNTEGSF 776
Query: 249 QCVSPECPEGSGNVSYVKTSPFQCERNPCPMDSRPCRH 286
+C C +G + + QCE D C+H
Sbjct: 777 RCT---CGQG----YQLSAAKDQCE------DIDECQH 801
Score = 65.1 bits (157), Expect = 1e-10
Identities = 34/83 (40%), Positives = 44/83 (53%), Gaps = 10/83 (12%)
Query: 177 TDVNECELYGQEGRPRLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVC 235
T++NEC + P +C C+N P Y C C GYR + C D+DEC +Q +C
Sbjct: 547 TEINECTV-----NPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLC 601
Query: 236 PQGTTCINTGGSFQCVSPECPEG 258
QG C NT GSF C+ CP G
Sbjct: 602 SQG-RCENTEGSFLCI---CPAG 620
Score = 60.5 bits (145), Expect = 3e-09
Identities = 53/158 (33%), Positives = 69/158 (43%), Gaps = 25/158 (15%)
Query: 102 EVHFTCNPGFRLVGPSSVVCL-PNGTWTGEQ-PHCRGISECSSQPCQNGGTCVEGVNQYR 159
+V C+ G S +C+ P G E+ +C + EC G CV V +R
Sbjct: 596 QVQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFR 655
Query: 160 C-ICPPG---RTGNRCQHQAQTDVNECELYGQEGRPRLCM-HACVNTPGSYRCT-CPGGY 213
C C G RC+ D++EC P C CVN+PGSY+C C G+
Sbjct: 656 CEYCDSGYRMTQRGRCE-----DIDECL------NPSTCPDEQCVNSPGSYQCVPCTEGF 704
Query: 214 RTLADGKSCEDVDECVGLQP-VCPQGTTCINTGGSFQC 250
R C DVDEC L+P VC G C N GS+ C
Sbjct: 705 R--GWNGQCLDVDEC--LEPNVCANG-DCSNLEGSYMC 737
Score = 50.4 bits (119), Expect = 3e-06
Identities = 36/114 (31%), Positives = 49/114 (42%), Gaps = 9/114 (7%)
Query: 140 CSSQPCQNGGTC--VEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMHA 197
C PC GT E + + P G + + + D +EC L+GQE +C +
Sbjct: 1059 CEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQE----ICKNG 1114
Query: 198 -CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQC 250
C+NT Y C C G C D+DEC C G C+NT GS+ C
Sbjct: 1115 FCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQD-PSSCIDG-QCVNTEGSYNC 1166
Score = 45.4 bits (106), Expect = 9e-05
Identities = 30/89 (33%), Positives = 41/89 (46%), Gaps = 5/89 (5%)
Query: 145 CQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMHA-CVNTPG 203
C+NG CV Y C C G + + DVNEC+ R LC +A C+NT G
Sbjct: 1306 CENG-RCVRVQEGYTCDCFDGYHLDTAKMTC-VDVNECDELNN--RMSLCKNAKCINTDG 1361
Query: 204 SYRCTCPGGYRTLADGKSCEDVDECVGLQ 232
SY+C C GY C ++ + L+
Sbjct: 1362 SYKCLCLPGYVPSDKPNYCTPLNTALNLE 1390
Score = 45.1 bits (105), Expect = 1e-04
Identities = 30/97 (30%), Positives = 41/97 (42%), Gaps = 8/97 (8%)
Query: 115 GPSSVVCLPNGTWTGEQPHCRGISEC-SSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQH 173
G VC + + + C I EC ++ C + G C +RC+C G +
Sbjct: 898 GSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQ-DG 956
Query: 174 QAQTDVNECELYGQEGRPRLCMHA-CVNTPGSYRCTC 209
Q DVNECEL +C A C N GS+ C C
Sbjct: 957 QGCVDVNECELLSG-----VCGEAFCENVEGSFLCVC 988
Score = 40.4 bits (93), Expect = 0.003
Identities = 21/57 (36%), Positives = 28/57 (49%), Gaps = 4/57 (7%)
Query: 198 CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQ---PVCPQGTTCINTGGSFQCV 251
CV Y C C GY +C DV+EC L +C + CINT GS++C+
Sbjct: 1311 CVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLC-KNAKCINTDGSYKCL 1366
Score = 40.0 bits (92), Expect = 0.004
Identities = 30/88 (34%), Positives = 40/88 (45%), Gaps = 13/88 (14%)
Query: 136 GISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCM 195
G ++C P + G NQ C PG R + D+NEC+L G +C
Sbjct: 264 GFNKCQKCPKKPS---YHGYNQMM-ECLPGY--KRVNNTFCQDINECQLQG------VCP 311
Query: 196 HA-CVNTPGSYRCTCPGGYRTLADGKSC 222
+ C+NT GSYRCTC G+ SC
Sbjct: 312 NGECLNTMGSYRCTCKIGFGPDPTFSSC 339
Score = 37.0 bits (84), Expect = 0.031
Identities = 29/99 (29%), Positives = 42/99 (42%), Gaps = 16/99 (16%)
Query: 145 CQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMHA-CVNTPG 203
C+NG C+ Y C C G + + Q D++EC+ P C+ CVNT G
Sbjct: 1111 CKNG-FCLNTRPGYECYCKQGTYYDPVKLQC-FDMDECQ------DPSSCIDGQCVNTEG 1162
Query: 204 SYRCTC-------PGGYRTLADGKSCEDVDECVGLQPVC 235
SY C C R + +S E ++E Q +C
Sbjct: 1163 SYNCFCTHPMVLDASEKRCIRPAESNEQIEETDVYQDLC 1201
Score = 36.6 bits (83), Expect = 0.040
Identities = 55/209 (26%), Positives = 70/209 (33%), Gaps = 30/209 (14%)
Query: 121 CLPNGTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICP----PGRTGNRCQHQAQ 176
CLP G C+ I+EC Q G C+ + YRC C P T + C
Sbjct: 286 CLP-GYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPP 344
Query: 177 TDVNE-CELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVC 235
E Y R CMH C C G A G CE C
Sbjct: 345 VISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVG---KAWGPHCEK----------C 391
Query: 236 PQGTTCINTGGSFQCVSPECPEGSG-NVSYV-KTSPFQCERNPCPMDSRPCRHLPKTISF 293
P T +F+ + CP G G VS V + P P+ +P P S
Sbjct: 392 PLPGT-----AAFKEI---CPGGMGYTVSGVHRRRPIHHHVGKGPVFVKPKNTQPVAKST 443
Query: 294 HYLSLPSNLKTPITLFRMATASAPGRAGP 322
H LP+ + P+ + PG A P
Sbjct: 444 HPPPLPAK-EEPVEALTFSREHGPGVAEP 471
Score = 33.9 bits (76), Expect = 0.26
Identities = 14/29 (48%), Positives = 17/29 (58%), Gaps = 3/29 (10%)
Query: 144 PCQNGGTCVEGVNQYRCICPPGRTGNRCQ 172
PC NGG C ++ +C CPP TG CQ
Sbjct: 80 PCMNGGQCS---SRDKCQCPPNFTGKLCQ 105
>gi|24041035 notch 2 preproprotein [Homo sapiens]
Length = 2471
Score = 96.3 bits (238), Expect = 4e-20
Identities = 57/147 (38%), Positives = 75/147 (51%), Gaps = 25/147 (17%)
Query: 135 RGISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLC 194
R I +C + CQNGG CV+GVN Y C CPP TG C DV+EC L +P C
Sbjct: 259 RNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTE----DVDECLL-----QPNAC 309
Query: 195 MH--ACVNTPGSYRCTCPGGYRTLADGKSC-EDVDECVGLQPVCPQGTTCINTGGSFQCV 251
+ C N G Y C C G+ G C E++D+C C G+TCI+ SF C+
Sbjct: 310 QNGGTCANRNGGYGCVCVNGW----SGDDCSENIDDCAFAS--CTPGSTCIDRVASFSCM 363
Query: 252 SPECPEG-SGNVSYVKTSPFQCERNPC 277
CPEG +G + ++ + C NPC
Sbjct: 364 ---CPEGKAGLLCHLDDA---CISNPC 384
Score = 90.9 bits (224), Expect = 2e-18
Identities = 52/142 (36%), Positives = 74/142 (52%), Gaps = 20/142 (14%)
Query: 137 ISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMH 196
I +C + PCQNGG+C++GVN + C+C PG TG++C QTD+NEC P
Sbjct: 912 IDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKC----QTDMNEC-----LSEPCKNGG 962
Query: 197 ACVNTPGSYRCTCPGGYRTLADGKSCE-DVDECVGLQPVCPQGTTCINTGGSFQCVSPEC 255
C + SY C C G+ DG CE +++EC + C G TC++ SF C+ C
Sbjct: 963 TCSDYVNSYTCKCQAGF----DGVHCENNINECT--ESSCFNGGTCVDGINSFSCL---C 1013
Query: 256 PEGSGNVSYVKTSPFQCERNPC 277
P G S+ +C +PC
Sbjct: 1014 PVGFTG-SFCLHEINECSSHPC 1034
Score = 88.6 bits (218), Expect = 9e-18
Identities = 58/157 (36%), Positives = 75/157 (47%), Gaps = 33/157 (21%)
Query: 127 WTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYG 186
+TG++ C+ C S PC NG TC NQ+ C C G TG +C +TDVNEC++ G
Sbjct: 137 FTGKE--CQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKC----ETDVNECDIPG 190
Query: 187 QEGRPRLCMH--ACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINT 244
C H C+N PGSY+C CP G+ G+ C+ + P C G TC T
Sbjct: 191 H------CQHGGTCLNLPGSYQCQCPQGF----TGQYCDSLYVPCAPSP-CVNGGTCRQT 239
Query: 245 GG-SFQCVSPECPEGSGNVSYVKTSPFQCERN--PCP 278
G +F+C EGS CERN CP
Sbjct: 240 GDFTFECNCLPGFEGS-----------TCERNIDDCP 265
Score = 84.0 bits (206), Expect = 2e-16
Identities = 61/176 (34%), Positives = 77/176 (43%), Gaps = 21/176 (11%)
Query: 108 NPGFRLVGPSSVVCLPNGTWTGEQPHC-RGISECSSQPCQNGGTCVEGVNQYRCICPPGR 166
N G + G +S CL +TG C I+ECSS PC N GTCV+G+ YRC CP G
Sbjct: 998 NGGTCVDGINSFSCLCPVGFTGS--FCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGY 1055
Query: 167 TGNRCQHQAQTDVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTL---ADGKSCE 223
TG C QT VN C P CV +C CP G+ SC+
Sbjct: 1056 TGKNC----QTLVNLC-----SRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCD 1106
Query: 224 DVDECVG--LQPVCPQGTTCINTGGSFQCVSPECPEGSGNVSYVKTSPFQCERNPC 277
G ++ +C CIN G + C +CP G SY + +C NPC
Sbjct: 1107 IAASRRGVLVEHLCQHSGVCINAGNTHYC---QCPLGYTG-SYCEEQLDECASNPC 1158
Score = 83.2 bits (204), Expect = 4e-16
Identities = 59/177 (33%), Positives = 81/177 (45%), Gaps = 29/177 (16%)
Query: 103 VHFTCNPGFRLVGPSSVVCLPNGTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCIC 162
+H C G + S VC P +TG++ + I EC+S PC+ G TC+ GVN +RCIC
Sbjct: 655 IHGICMDG---INRYSCVCSPG--FTGQRCNI-DIDECASNPCRKGATCINGVNGFRCIC 708
Query: 163 PPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMHA-CVNTPGSYRCTCPGGYRTLADGKS 221
P G C Q VNEC C+H C Y+C C G+ G +
Sbjct: 709 PEGPHHPSCYSQ----VNEC-------LSNPCIHGNCTGGLSGYKCLCDAGW----VGIN 753
Query: 222 CE-DVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEGSGNVSYVKTSPFQCERNPC 277
CE D +EC L C G TC N ++C C +G + + + +C NPC
Sbjct: 754 CEVDKNEC--LSNPCQNGGTCDNLVNGYRCT---CKKGFKGYN-CQVNIDECASNPC 804
Score = 79.7 bits (195), Expect = 4e-15
Identities = 48/157 (30%), Positives = 70/157 (44%), Gaps = 28/157 (17%)
Query: 132 PHCR-GISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGR 190
P C I+EC S PCQN TC++ + + C+C PG G C + ++NEC +
Sbjct: 451 PRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHC----ELEINEC-----QSN 501
Query: 191 PRLCMHACVNTPGSYRCTCPGGYRTLADGKSCE-DVDECVGLQPVCPQGTTCINTGGSFQ 249
P + CV+ ++C CP G+ G C+ D+D+C C G CI+ ++
Sbjct: 502 PCVNNGQCVDKVNRFQCLCPPGF----TGPVCQIDIDDCSSTP--CLNGAKCIDHPNGYE 555
Query: 250 CVSPECPEGSGNVSYVKTSPFQCERNPCPMDSRPCRH 286
C +C G V CE N D PC H
Sbjct: 556 C---QCATGFTGV--------LCEENIDNCDPDPCHH 581
Score = 79.3 bits (194), Expect = 5e-15
Identities = 64/213 (30%), Positives = 87/213 (40%), Gaps = 45/213 (21%)
Query: 104 HFTCNPGFRLVGPSSVVCLPNGTWTGEQPHC-RGISECSSQP--CQNGGTCVEGVNQYRC 160
H N G + G ++ C WTG+ C + EC QP CQNGGTC Y C
Sbjct: 267 HRCQNGGVCVDGVNTYNCRCPPQWTGQ--FCTEDVDECLLQPNACQNGGTCANRNGGYGC 324
Query: 161 ICPPGRTGNRCQHQ-----------AQTDVNECELYG---QEGRPRLCMH---ACVNTP- 202
+C G +G+ C T ++ + EG+ L H AC++ P
Sbjct: 325 VCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPC 384
Query: 203 ------------GSYRCTCPGGYRTLADGKSC-EDVDEC-VGLQPVCPQGTTCINTGGSF 248
G Y CTCP GY+ G C EDVDEC + C C+NT G+F
Sbjct: 385 HKGALCDTNPLNGQYICTCPQGYK----GADCTEDVDECAMANSNPCEHAGKCVNTDGAF 440
Query: 249 QCVSPECPEGSGNVSYVKTSPFQCERNPCPMDS 281
C EC +G + +C +PC D+
Sbjct: 441 HC---ECLKGYAG-PRCEMDINECHSDPCQNDA 469
Score = 79.0 bits (193), Expect = 7e-15
Identities = 46/145 (31%), Positives = 72/145 (49%), Gaps = 23/145 (15%)
Query: 137 ISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMH 196
+ EC +QPCQNGGTC++ VN ++C CPPG G C+ ++++C R C++
Sbjct: 1188 VDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEE----NIDDC------ARGPHCLN 1237
Query: 197 A--CVNTPGSYRCTCPGGYRTLADGKSCE-DVDECVGLQPVCPQGT-TCINTGGSFQCVS 252
C++ G Y C C G+ G+ CE D++EC+ P +G+ CI + CV
Sbjct: 1238 GGQCMDRIGGYSCRCLPGFA----GERCEGDINECLS-NPCSSEGSLDCIQLTNDYLCVC 1292
Query: 253 PECPEGSGNVSYVKTSPFQCERNPC 277
G ++V C + PC
Sbjct: 1293 RSAFTGRHCETFVDV----CPQMPC 1313
Score = 77.8 bits (190), Expect = 2e-14
Identities = 56/195 (28%), Positives = 79/195 (40%), Gaps = 35/195 (17%)
Query: 114 VGPSSVVCLPNGTWTGEQPHCR-GISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQ 172
+G + +C+P HC I+EC S PC N G CV+ VN+++C+CPPG TG C
Sbjct: 475 IGGFTCLCMPGFKGV----HCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVC- 529
Query: 173 HQAQTDVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQ 232
Q D+++C P L C++ P Y C C G+ + ++ ++ D
Sbjct: 530 ---QIDIDDC-----SSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHH 581
Query: 233 PVCPQGT---TCINTGGSF---------QCVSPECPEGSGNVSYVK---------TSPFQ 271
C G TCI G +C S C + V TS
Sbjct: 582 GQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVN 641
Query: 272 CERNPCPMDSRPCRH 286
CE N S PC H
Sbjct: 642 CEINFDDCASNPCIH 656
Score = 74.3 bits (181), Expect = 2e-13
Identities = 46/147 (31%), Positives = 70/147 (47%), Gaps = 29/147 (19%)
Query: 137 ISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMH 196
+ EC+S PCQ+G TC + + YRC C PG G C++ +V+EC + +P
Sbjct: 1150 LDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEY----EVDEC-----QNQPCQNGG 1200
Query: 197 ACVNTPGSYRCTCPGGYRTLADGKSCED-VDECVGLQPVCPQGTTCINTGGSFQC----- 250
C++ ++C+CP G R G CE+ +D+C P C G C++ G + C
Sbjct: 1201 TCIDLVNHFKCSCPPGTR----GLLCEENIDDC-ARGPHCLNGGQCMDRIGGYSCRCLPG 1255
Query: 251 VSPECPEGSGNVSYVKTSPFQCERNPC 277
+ E EG N +C NPC
Sbjct: 1256 FAGERCEGDIN---------ECLSNPC 1273
Score = 72.0 bits (175), Expect = 9e-13
Identities = 50/146 (34%), Positives = 65/146 (44%), Gaps = 26/146 (17%)
Query: 137 ISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMH 196
I EC+S PC N GTC + ++ Y C C TG C QT + C P C +
Sbjct: 796 IDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNC----QTVLAPCS-------PNPCEN 844
Query: 197 A--CVNTPG--SYRCTCPGGYRTLADGKSCE-DVDECVGLQPVCPQGTTCINTGGSFQCV 251
A C +P SY C C G++ G+ C D+DEC+ C C NT GS+ C
Sbjct: 845 AAVCKESPNFESYTCLCAPGWQ----GQRCTIDIDECI--SKPCMNHGLCHNTQGSYMC- 897
Query: 252 SPECPEGSGNVSYVKTSPFQCERNPC 277
ECP G + + C NPC
Sbjct: 898 --ECPPGFSGMD-CEEDIDDCLANPC 920
Score = 68.6 bits (166), Expect = 1e-11
Identities = 62/220 (28%), Positives = 84/220 (38%), Gaps = 51/220 (23%)
Query: 107 CNPGFR-LVGPSSVVCLPNGTWTGEQP------HCRGISECSSQPCQNGGTCVEG--VNQ 157
C G+ V V NGT + P +C+ C CQNGGTCV + +
Sbjct: 28 CRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGK 87
Query: 158 YRCICPPGRTGNRCQ-------------------HQAQTDVNECEL-YGQEGRPRLCMHA 197
C C G TG CQ H D EC G G+ A
Sbjct: 88 ATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDA 147
Query: 198 CVNTP-----------GSYRCTCPGGYRTLADGKSCE-DVDECVGLQPVCPQGTTCINTG 245
C++ P + C C G+ G+ CE DV+EC + C G TC+N
Sbjct: 148 CLSHPCANGSTCTTVANQFSCKCLTGF----TGQKCETDVNEC-DIPGHCQHGGTCLNLP 202
Query: 246 GSFQCVSPECPEGSGNVSYVKTSPFQCERNPCPMDSRPCR 285
GS+QC +CP+G Y + C +PC ++ CR
Sbjct: 203 GSYQC---QCPQGFTG-QYCDSLYVPCAPSPC-VNGGTCR 237
Score = 63.2 bits (152), Expect = 4e-10
Identities = 53/179 (29%), Positives = 71/179 (39%), Gaps = 44/179 (24%)
Query: 114 VGPSSVVCLPNGTWTGEQPHCRG-ISECSSQPCQNGGT--CVEGVNQYRCICPPGRTGNR 170
+G S CLP + GE+ C G I+EC S PC + G+ C++ N Y C+C TG
Sbjct: 1245 IGGYSCRCLPG--FAGER--CEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRH 1300
Query: 171 CQHQAQTDVNECELYGQEGRPRLCMHACV---NTPGSYRCTCPGGYRTLADGKSCEDVDE 227
C+ T V+ C P L C N P + C CP G+ SC V
Sbjct: 1301 CE----TFVDVCPQM-----PCLNGGTCAVASNMPDGFICRCPPGFSGARCQSSCGQVK- 1350
Query: 228 CVGLQPVCPQGTTCINTGGSFQCVSPECPEGSGNVSYVKTSPFQCERNPCPMDSRPCRH 286
C +G C++T +C P SP CE S PC+H
Sbjct: 1351 -------CRKGEQCVHTASGPRCFCP--------------SPRDCESG---CASSPCQH 1385
Score = 59.7 bits (143), Expect = 4e-09
Identities = 41/145 (28%), Positives = 61/145 (42%), Gaps = 23/145 (15%)
Query: 137 ISECS---SQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRL 193
+ EC+ S PC++ G CV + C C G G RC + D+NEC P
Sbjct: 416 VDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRC----EMDINEC-----HSDPCQ 466
Query: 194 CMHACVNTPGSYRCTCPGGYRTLADGKSCE-DVDECVGLQPVCPQGTTCINTGGSFQCVS 252
C++ G + C C G++ G CE +++EC C C++ FQC+
Sbjct: 467 NDATCLDKIGGFTCLCMPGFK----GVHCELEINEC--QSNPCVNNGQCVDKVNRFQCLC 520
Query: 253 PECPEGSGNVSYVKTSPFQCERNPC 277
P P +G V + C PC
Sbjct: 521 P--PGFTGPVCQIDID--DCSSTPC 541
Score = 39.3 bits (90), Expect = 0.006
Identities = 26/82 (31%), Positives = 36/82 (43%), Gaps = 11/82 (13%)
Query: 138 SECSSQPCQNGGTC--VEGVNQYRCICPPGRTGNRCQ---HQAQTDVNEC--ELYGQEGR 190
S C+S PCQ+GG+C Y C C P +G+RC+ T C + + R
Sbjct: 1376 SGCASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTAPPSTPPATCLSQYCADKAR 1435
Query: 191 PRLCMHACVNTPGSYRCTCPGG 212
+C AC S+ C GG
Sbjct: 1436 DGVCDEAC----NSHACQWDGG 1453
Score = 30.4 bits (67), Expect = 2.9
Identities = 16/58 (27%), Positives = 20/58 (34%), Gaps = 12/58 (20%)
Query: 138 SECSSQPCQNGGTCVEGVNQYRCICP------------PGRTGNRCQHQAQTDVNECE 183
S C C+ G CV + RC CP P + G C Q Q C+
Sbjct: 1344 SSCGQVKCRKGEQCVHTASGPRCFCPSPRDCESGCASSPCQHGGSCHPQRQPPYYSCQ 1401
>gi|56237021 fibrillin 3 precursor [Homo sapiens]
Length = 2809
Score = 95.5 bits (236), Expect = 7e-20
Identities = 67/196 (34%), Positives = 89/196 (45%), Gaps = 28/196 (14%)
Query: 102 EVHFTCNPGFRLVGPSSVVCLPNGTW--TGEQPHCRGISECSSQPCQNGGTCVEGVNQYR 159
E+ C+ G + S +CL + + + +Q C I EC QPC NG TC + Y
Sbjct: 1811 EIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNG-TCKNIIGSYN 1869
Query: 160 CICPPGRTGNRCQHQAQ-TDVNECE-LYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLA 217
C+C PG H D +EC L GQ R C+NT GS+ C C G+ A
Sbjct: 1870 CLCFPGFV---VTHNGDCVDFDECTTLVGQVCR----FGHCLNTAGSFHCLCQDGFELTA 1922
Query: 218 DGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEGSGNVSYVKTSPFQCERNPC 277
DGK+C D +EC+ L C G TC N GSF+C+ CP G FQ + + C
Sbjct: 1923 DGKNCVDTNECLSLAGTCLPG-TCQNLEGSFRCI---CPPG-----------FQVQSDHC 1967
Query: 278 PMDSRPCRHLPKTISF 293
+D C P F
Sbjct: 1968 -IDIDECSEEPNLCLF 1982
Score = 90.9 bits (224), Expect = 2e-18
Identities = 54/149 (36%), Positives = 67/149 (44%), Gaps = 11/149 (7%)
Query: 104 HFTCNPGFRLVGPSSVVCLPNGTWTGEQPHCRGISECSSQPCQNG-GTCVEGVNQYRCIC 162
H TC VG C ++ +C I EC P G GTCV + C C
Sbjct: 999 HGTCR---NTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECEC 1055
Query: 163 PPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMHA-CVNTPGSYRCTCPGGYRTLADGKS 221
PG + DV+EC P LC C NT GSY+C CP G+ A G +
Sbjct: 1056 FPGYESGFMLMKNCMDVDECAR-----DPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTA 1110
Query: 222 CEDVDECVGLQPVCPQGTTCINTGGSFQC 250
CED+DEC +CP G C+N G+FQC
Sbjct: 1111 CEDIDECSLSDGLCPHG-QCVNVIGAFQC 1138
Score = 89.7 bits (221), Expect = 4e-18
Identities = 59/152 (38%), Positives = 77/152 (50%), Gaps = 13/152 (8%)
Query: 104 HFT--CNPGFRLVGPSSVVCLPNGTWTGE-QPHCRGISECSSQPCQNGGTCVEGVNQYRC 160
HFT C G L PSS C N +T + + C + EC+S PC +G CV Y C
Sbjct: 414 HFTNLCLNGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGD-CVNIPGTYHC 472
Query: 161 ICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLC-MHACVNTPGSYRCTCPGGYRTLADG 219
C PG + QA DV+EC + G LC + CVNT GS++C C G+ DG
Sbjct: 473 RCYPGFQATPTR-QACVDVDECIVSGG-----LCHLGRCVNTEGSFQCVCNAGFELSPDG 526
Query: 220 KSCEDVDECVGLQPVCPQGTTCINTGGSFQCV 251
K+C D +EC +C G C+N GSF C+
Sbjct: 527 KNCVDHNEC-ATSTMCVNG-VCLNEDGSFSCL 556
Score = 86.7 bits (213), Expect = 3e-17
Identities = 53/164 (32%), Positives = 79/164 (48%), Gaps = 23/164 (14%)
Query: 133 HCRGISECSSQPCQ-NGGTCVEGVNQYRCICPPGRT----GNRCQHQAQTDVNECELYGQ 187
+C + EC+ P GGTC Y+C CPPG G C+ D++EC L
Sbjct: 1068 NCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACE-----DIDECSL--S 1120
Query: 188 EGRPRLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGG 246
+G LC H CVN G+++C+C G+++ D + C D++EC C CINT G
Sbjct: 1121 DG---LCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCD--VHCINTEG 1175
Query: 247 SFQCVSPECPEGSGNVSYVKTSPF--QCERNPCPMDSRPCRHLP 288
S++C C +G + + +CE NP D C ++P
Sbjct: 1176 SYRC---SCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMP 1216
Score = 85.9 bits (211), Expect = 6e-17
Identities = 56/159 (35%), Positives = 74/159 (46%), Gaps = 13/159 (8%)
Query: 121 CLPNGTWTGEQPHCRGISECS-SQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDV 179
C P T + C I ECS S G CV + ++C C G Q D+
Sbjct: 1098 CPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTP-DRQGCVDI 1156
Query: 180 NECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGT 239
NEC + Q G C C+NT GSYRC+C GY + DG++C DVDEC VC QG
Sbjct: 1157 NECRV--QNGG---CDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQG- 1210
Query: 240 TCINTGGSFQCVSPECPEGSGNVSYVKT--SPFQCERNP 276
C N G +C+ C +G ++T +C+ NP
Sbjct: 1211 HCTNMPGGHRCL---CYDGFMATPDMRTCVDVDECDLNP 1246
Score = 85.5 bits (210), Expect = 8e-17
Identities = 51/128 (39%), Positives = 58/128 (45%), Gaps = 13/128 (10%)
Query: 133 HCRGISECS-SQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRP 191
+C ECS PC G TC + + C C G D++EC L P
Sbjct: 2123 NCVDTDECSVGHPCGQG-TCTNVIGGFECACADGFEPGLMM--TCEDIDECSL-----NP 2174
Query: 192 RLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVC-PQGTTCINTGGSFQC 250
LC C NT GSY CTCP GY DG C DVDEC Q C +G C N G+F C
Sbjct: 2175 LLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFAC 2234
Query: 251 VSPECPEG 258
V CP G
Sbjct: 2235 V---CPPG 2239
Score = 85.1 bits (209), Expect = 1e-16
Identities = 56/160 (35%), Positives = 68/160 (42%), Gaps = 18/160 (11%)
Query: 101 HEVHFTCNPGFRLVGPSSVVCLPNGTWTGEQPHCRGISECSSQP--CQNGGTCVEGVNQY 158
H F C VG + C P +T C ECS+QP C G C +
Sbjct: 2455 HNCQFLC---VNTVGAFTCRCPPG--FTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSF 2509
Query: 159 RCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLAD 218
RC C G T H + DVNEC+ P C H C N G YRC+CP G+ +
Sbjct: 2510 RCECHQGFTLVSSGHGCE-DVNECD------GPHRCQHGCQNQLGGYRCSCPQGFTQHSQ 2562
Query: 219 GKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEG 258
C D +EC P C +C NT G F+CV CP G
Sbjct: 2563 WAQCVDENECALSPPTC-GSASCRNTLGGFRCV---CPSG 2598
Score = 83.2 bits (204), Expect = 4e-16
Identities = 77/263 (29%), Positives = 104/263 (39%), Gaps = 41/263 (15%)
Query: 134 CRGISECSS-QPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPR 192
C ++EC CQ+G C + YRC CP G T Q D NEC L P
Sbjct: 2526 CEDVNECDGPHRCQHG--CQNQLGGYRCSCPQGFT-QHSQWAQCVDENECAL-----SPP 2577
Query: 193 LCMHA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCV 251
C A C NT G +RC CP G+ C++VDEC G + C +C NT G F C
Sbjct: 2578 TCGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPCSY--SCANTPGGFLCG 2635
Query: 252 SPE---------CPEGSGNVSYVKTSP-----------FQCERNPCPMDSRPCR--HLPK 289
P+ C G G + +P ++C+ N RP R H
Sbjct: 2636 CPQGYFRAGQGHCVSGLGFSPGPQDTPDKEELLSSEACYECKINGLSPRDRPRRSAHRDH 2695
Query: 290 TISFHYLSLPSNLKTPITLFRMATAS-----APGRAG-PNSLRFGIVGGNSRGHFVMQRS 343
++ L + L + L + A P G +R+ IV GN +G F M
Sbjct: 2696 QVNLATLDSEALLTLGLNLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQGFFRMHHL 2755
Query: 344 DRQTGDLILVQNLEGPQTLEVDV 366
R L L + GP T ++V
Sbjct: 2756 -RGVSSLQLGRRRPGPGTYRLEV 2777
Score = 82.0 bits (201), Expect = 8e-16
Identities = 58/194 (29%), Positives = 81/194 (41%), Gaps = 24/194 (12%)
Query: 107 CNPGFRLVGPSSVVCLPNGT---------WTGEQPHCRGISECS--SQPCQNGGTCVEGV 155
C G R GP +C GT +G R + EC + C +G C+ +
Sbjct: 2325 CCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHG-ECINSL 2383
Query: 156 NQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRT 215
+RC C G T + D++EC P+ C C NT GS+ C+CP GY
Sbjct: 2384 GSFRCHCQAGYTPDATATTC-LDMDECSQV-----PKPCTFLCKNTKGSFLCSCPRGYLL 2437
Query: 216 LADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEGSGNVSYVKTSPFQCERN 275
DG++C+D+DEC Q C C+NT G+F C CP G +C
Sbjct: 2438 EEDGRTCKDLDECTSRQHNCQ--FLCVNTVGAFTC---RCPPGFTQHHQACFDNDECSAQ 2492
Query: 276 PCPMDSR-PCRHLP 288
P P + C + P
Sbjct: 2493 PGPCGAHGHCHNTP 2506
Score = 81.3 bits (199), Expect = 1e-15
Identities = 59/184 (32%), Positives = 79/184 (42%), Gaps = 27/184 (14%)
Query: 104 HFTCNPGFRLVGPSSVVCLPNGTWTGEQPHCRGISECSSQP--CQNGGTCVEGVNQYRCI 161
H +C + G S CLP W G+ C + EC SQ C G C+ YRC
Sbjct: 1294 HASC---LNIPGSFSCRCLPG--WVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCT 1348
Query: 162 CPPGRTGNR--CQHQAQTDVNECELYGQEGRPRLCMHA-CVNTPGSYRCTCPGGYRTLAD 218
C G G+ C+ D +EC LC + C+N PG YRC C G+ D
Sbjct: 1349 CRQGFAGDGFFCE-----DRDECA-----ENVDLCDNGQCLNAPGGYRCECEMGFDPTED 1398
Query: 219 GKSCEDVDECVGLQPVCPQGTTCINTGGSFQCV---SPECPEGSGNVSYVK--TSPFQCE 273
++C+DVDEC +C G +C N G F+C+ E G GN + + P C
Sbjct: 1399 HRACQDVDEC-AQGNLCAFG-SCENLPGMFRCICNGGYELDRGGGNCTDINECADPVNCI 1456
Query: 274 RNPC 277
C
Sbjct: 1457 NGVC 1460
Score = 79.7 bits (195), Expect = 4e-15
Identities = 50/132 (37%), Positives = 69/132 (52%), Gaps = 15/132 (11%)
Query: 131 QPHCRGISECSSQP--CQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQE 188
+P + ++EC P C +G TC V + C C G + Q + TD++EC +
Sbjct: 981 RPFYKDVNECKVFPGLCTHG-TCRNTVGSFHCACAGGFALD-AQERNCTDIDECRI---- 1034
Query: 189 GRPRLC-MHACVNTPGSYRCTCPGGYRT-LADGKSCEDVDECVGLQPVCPQGTTCINTGG 246
P LC CVNTPGS+ C C GY + K+C DVDEC P+ +G TC NT G
Sbjct: 1035 -SPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECAR-DPLLCRGGTCTNTDG 1092
Query: 247 SFQCVSPECPEG 258
S++C +CP G
Sbjct: 1093 SYKC---QCPPG 1101
Score = 77.8 bits (190), Expect = 2e-14
Identities = 50/143 (34%), Positives = 69/143 (48%), Gaps = 10/143 (6%)
Query: 137 ISECSSQP--CQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLC 194
I EC P C NG C+ + +RC CP G N A DV+EC G P
Sbjct: 1722 IDECGEIPAICANG-ICINQIGSFRCECPAGFNYNSIL-LACEDVDEC---GSRESPCQQ 1776
Query: 195 MHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPE 254
C+N PGSYRC C GY+ L+ G +C +EC + VC G C++T GS+ C+
Sbjct: 1777 NADCINIPGSYRCKCTRGYK-LSPGGACVGRNECREIPNVCSHG-DCMDTEGSYMCLCHR 1834
Query: 255 CPEGSGNVSYVKTSPFQCERNPC 277
+ S + + +C+R PC
Sbjct: 1835 GFQASADQTLCMDID-ECDRQPC 1856
Score = 75.5 bits (184), Expect = 8e-14
Identities = 51/146 (34%), Positives = 65/146 (44%), Gaps = 22/146 (15%)
Query: 113 LVGPSSVVCLPNGTWTGEQPHCRGISECSSQPCQNGGT---CVEGVNQYRCICPPGRT-- 167
++G C T ++ C I+EC QNGG C+ YRC C G +
Sbjct: 1132 VIGAFQCSCHAGFQSTPDRQGCVDINECR---VQNGGCDVHCINTEGSYRCSCGQGYSLM 1188
Query: 168 --GNRCQHQAQTDVNECELYGQEGRPRLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCED 224
G C DV+ECE PR+C C N PG +RC C G+ D ++C D
Sbjct: 1189 PDGRAC-----ADVDECE-----ENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVD 1238
Query: 225 VDECVGLQPVCPQGTTCINTGGSFQC 250
VDEC +C G C NT GSF C
Sbjct: 1239 VDECDLNPHICLHG-DCENTKGSFVC 1263
Score = 73.2 bits (178), Expect = 4e-13
Identities = 46/124 (37%), Positives = 58/124 (46%), Gaps = 19/124 (15%)
Query: 134 CRGISECSSQ--PCQNGGTCVEGVNQYRCICPPG---RTGNRCQHQAQTDVNECELYGQE 188
C + EC S+ PCQ C+ YRC C G G C + NEC
Sbjct: 1761 CEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGACVGR-----NECREI--- 1812
Query: 189 GRPRLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGS 247
P +C H C++T GSY C C G++ AD C D+DEC QP C G TC N GS
Sbjct: 1813 --PNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDEC-DRQP-CGNG-TCKNIIGS 1867
Query: 248 FQCV 251
+ C+
Sbjct: 1868 YNCL 1871
Score = 71.6 bits (174), Expect = 1e-12
Identities = 48/144 (33%), Positives = 65/144 (45%), Gaps = 15/144 (10%)
Query: 115 GPSSVVCLPN-GTWTGEQPHCRGISECSSQPCQNGGTC-VEGVNQYRCICPPGR--TGNR 170
G S + C G C + PC+ C + +YR +CP G NR
Sbjct: 1500 GDSGISCSAEIGVGVTRASCCCSLGRAWGNPCE---LCPMANTTEYRTLCPGGEGFQPNR 1556
Query: 171 CQHQAQTDVNECELYGQEGRPRLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECV 229
+ D++EC+ P LC CVNT GS++C CP GY + CED+DEC
Sbjct: 1557 ITVILE-DIDECQEL-----PGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECS 1610
Query: 230 GLQPVCPQGTTCINTGGSFQCVSP 253
+C G TC NT G++ CV P
Sbjct: 1611 THSGICGPG-TCYNTLGNYTCVCP 1633
Score = 71.2 bits (173), Expect = 1e-12
Identities = 41/120 (34%), Positives = 51/120 (42%), Gaps = 10/120 (8%)
Query: 134 CRGISECSSQP--CQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRP 191
C + EC P C G C +RC+C G DV+EC+L P
Sbjct: 1194 CADVDECEENPRVCDQGH-CTNMPGGHRCLCYDGFMATPDMRTC-VDVDECDL-----NP 1246
Query: 192 RLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQC 250
+C+H C NT GS+ C C GY C DVDEC C +C+N GSF C
Sbjct: 1247 HICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSC 1306
Score = 71.2 bits (173), Expect = 1e-12
Identities = 43/127 (33%), Positives = 58/127 (45%), Gaps = 14/127 (11%)
Query: 134 CRGISECS--SQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRP 191
C + EC C + +C+ + C C PG G+ + D++EC P
Sbjct: 1278 CSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH---DLDECVSQEHRCSP 1334
Query: 192 RLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCV 251
R C+N PGSYRCTC G+ DG CED DEC +C G C+N G ++C
Sbjct: 1335 R---GDCLNVPGSYRCTCRQGF--AGDGFFCEDRDECAENVDLCDNG-QCLNAPGGYRC- 1387
Query: 252 SPECPEG 258
EC G
Sbjct: 1388 --ECEMG 1392
Score = 69.3 bits (168), Expect = 6e-12
Identities = 47/125 (37%), Positives = 60/125 (48%), Gaps = 16/125 (12%)
Query: 140 CSSQPCQN-GGTCV----EGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLC 194
CS +P + G C EG ++ +CP G ++ DVNEC P +C
Sbjct: 2041 CSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECA-----ENPGVC 2095
Query: 195 MHA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSP 253
+ CVNT GS+RC CP GY G +C D DEC P C QG TC N G F+C
Sbjct: 2096 TNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHP-CGQG-TCTNVIGGFECA-- 2151
Query: 254 ECPEG 258
C +G
Sbjct: 2152 -CADG 2155
Score = 67.4 bits (163), Expect = 2e-11
Identities = 61/196 (31%), Positives = 81/196 (41%), Gaps = 31/196 (15%)
Query: 99 VDHEVHFTCNPGFRLVGPSSVVCLPNGTWTGEQPHCRGISECSSQPCQNGGTC-VEGVNQ 157
VD V TC + + S GT T + C +PCQ C + +
Sbjct: 612 VDTHVRSTC---YGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQ---LCPAKDSAE 665
Query: 158 YRCICPPG---RTGNRCQHQAQTDVNECELYGQEGRPRLCMHA-CVNTPGSYRCTCPGGY 213
++ +C G T R D+NEC L P +C + C N GSYRC C GY
Sbjct: 666 FQALCSSGLGITTDGR-------DINECAL-----DPEVCANGVCENLRGSYRCVCNLGY 713
Query: 214 RTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEG--SGNVSYVKTSPFQ 271
A GK C DVDEC +C G C N+ GS+ C CP G + + +
Sbjct: 714 EAGASGKDCTDVDECALNSLLCDNG-WCQNSPGSYSC---SCPPGFHFWQDTEICKDVDE 769
Query: 272 CERNPCPMDSRPCRHL 287
C +PC S CR+L
Sbjct: 770 CLSSPCV--SGVCRNL 783
Score = 63.2 bits (152), Expect = 4e-10
Identities = 39/112 (34%), Positives = 52/112 (46%), Gaps = 17/112 (15%)
Query: 178 DVNECELYGQEGRPRLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCP 236
D++EC P +C + C+N GS+RC CP G+ + +CEDVDEC + C
Sbjct: 1721 DIDECGEI-----PAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQ 1775
Query: 237 QGTTCINTGGSFQCVSPECPEGSGNVSYVKTSPFQC--ERNPCPMDSRPCRH 286
Q CIN GS++C +C G K SP RN C C H
Sbjct: 1776 QNADCINIPGSYRC---KCTRG------YKLSPGGACVGRNECREIPNVCSH 1818
Score = 63.2 bits (152), Expect = 4e-10
Identities = 42/132 (31%), Positives = 59/132 (44%), Gaps = 12/132 (9%)
Query: 134 CRGISECSS--QPCQ-NGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGR 190
CR + EC+ Q C G C + + C+CPPG + TD NEC +
Sbjct: 2205 CRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECH-----AQ 2259
Query: 191 PRLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQ 249
P LC++ CVNT GS+RC C G++ C D+ + V T C + S +
Sbjct: 2260 PDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQ--TMCRSLSSSSE 2317
Query: 250 CVS-PECPEGSG 260
V+ EC G G
Sbjct: 2318 AVTRAECCCGGG 2329
Score = 62.4 bits (150), Expect = 7e-10
Identities = 57/210 (27%), Positives = 79/210 (37%), Gaps = 45/210 (21%)
Query: 92 KFGSKYLVDHEVHFTCNPGFRLVGPSSVVCLPNGTWTGEQPHCRGISECSSQPCQNGGTC 151
+FG H C GF L T + +C +EC S GTC
Sbjct: 1899 RFGHCLNTAGSFHCLCQDGFEL--------------TADGKNCVDTNECLSL----AGTC 1940
Query: 152 VEGVNQ-----YRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMHA-CVNTPGSY 205
+ G Q +RCICPPG + Q D++EC P LC+ C N+PGS+
Sbjct: 1941 LPGTCQNLEGSFRCICPPGF---QVQSDHCIDIDECS-----EEPNLCLFGTCTNSPGSF 1992
Query: 206 RCTCPGGYRTLADGKSCEDVDEC---VGLQPVCPQGTTCINTGGSFQCVSPECPEG---- 258
+C CP G+ +G C D + + NT + C S EG
Sbjct: 1993 QCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDP 2052
Query: 259 ------SGNVSYVKTSPFQCERNPCPMDSR 282
G+ ++ + PF P P DSR
Sbjct: 2053 CELCPQEGSAAFQELCPFGHGAVPGPDDSR 2082
Score = 59.3 bits (142), Expect = 6e-09
Identities = 39/125 (31%), Positives = 53/125 (42%), Gaps = 18/125 (14%)
Query: 107 CNPGFRLVGPSSVVCLPNGTWTGEQPH--CRGISECSSQPCQNGGTCVEGVNQYRCICPP 164
C+ G L P C + + H C+ + EC+ G+C +RCIC
Sbjct: 1373 CDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNG 1432
Query: 165 G----RTGNRCQHQAQTDVNECELYGQEGRPRLCMHA-CVNTPGSYRCTCPGGYRTLADG 219
G R G C TD+NEC P C++ C+NTPGSY C+CP + G
Sbjct: 1433 GYELDRGGGNC-----TDINEC------ADPVNCINGVCINTPGSYLCSCPQDFELNPSG 1481
Query: 220 KSCED 224
C D
Sbjct: 1482 VGCVD 1486
Score = 58.2 bits (139), Expect = 1e-08
Identities = 68/222 (30%), Positives = 84/222 (37%), Gaps = 55/222 (24%)
Query: 107 CNPGFRLVGPSSVVCLPNGTWTG----EQPHC----RGISECSSQPCQNGGTCVEGVNQY 158
C PG RL PS CL + T ++ C +G S S+ C G G
Sbjct: 791 CGPGSRL-DPSGTFCLDSTKGTCWLKIQESRCEVNLQGAS-LRSECCATLGAAW-GSPCE 847
Query: 159 RCICPPG-------RTGNRCQHQAQTDVNECELYGQEGRPRLCMHA-CVNTPGSYRCTCP 210
RC P TG C DVNECE + P +C + CVNT GS+RC CP
Sbjct: 848 RCEIDPACARGFARMTGVTCD-----DVNECESF-----PGVCPNGRCVNTAGSFRCECP 897
Query: 211 GGYRTLADGKSCEDV-----------DEC-VGLQPVCPQGTTCINTGGSF-----QCVSP 253
G A G+ C DV DEC V L C + G + C P
Sbjct: 898 EGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDP 957
Query: 254 E-------CPEGSGNVS--YVKTSPFQCERNPCPMDSRPCRH 286
E CP G G S ++ PF + N C + C H
Sbjct: 958 ESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTH 999
Score = 57.4 bits (137), Expect = 2e-08
Identities = 37/123 (30%), Positives = 54/123 (43%), Gaps = 30/123 (24%)
Query: 107 CNPGFRLVGPSSVVCLPNGTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPPGR 166
CN GF L P+G +C +EC++ G C+ + C+C PG
Sbjct: 516 CNAGFELS--------PDGK------NCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGF 561
Query: 167 T----GNRCQHQAQTDVNECELYGQEGRPRLCMHA-CVNTPGSYRCTCPGGYRTLADGKS 221
G+ C D++EC+ P +C++ C NT GS+RC C GG DG+
Sbjct: 562 LLAPGGHYCM-----DIDECQT------PGICVNGHCTNTEGSFRCQCLGGLAVGTDGRV 610
Query: 222 CED 224
C D
Sbjct: 611 CVD 613
Score = 57.0 bits (136), Expect = 3e-08
Identities = 52/169 (30%), Positives = 67/169 (39%), Gaps = 40/169 (23%)
Query: 118 SVVCLPNGTWTGEQPHCRG--ISECSSQP-----CQNGGTCVEGVNQYRCICPPGRTGNR 170
SV C+ GT G C+ QP C NGG C+ G N RC C G G +
Sbjct: 121 SVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCI-GPN--RCACVYGFMGPQ 177
Query: 171 CQHQAQTDVNECELYGQEGRPRLCMHA----------CVNTPG-----------SYRCTC 209
C+ +T +GQ G P C H C T G + C
Sbjct: 178 CERDYRTG----PCFGQVG-PEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPC 232
Query: 210 PGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEG 258
G+ +C+DVDEC + +C QG +C+N GSF C CP G
Sbjct: 233 RRGFIPNIHTGACQDVDECQAVPGLC-QGGSCVNMVGSFHC---RCPVG 277
Score = 55.1 bits (131), Expect = 1e-07
Identities = 33/96 (34%), Positives = 46/96 (47%), Gaps = 10/96 (10%)
Query: 137 ISECSSQP--CQNGGTCVEGVNQYRCICPPGRTGNRCQH-QAQTDVNECELYGQEGRPRL 193
I EC P CQ GG CV ++C CPPG + +H + D++EC + P
Sbjct: 1564 IDECQELPGLCQ-GGDCVNTFGSFQCECPPGY--HLSEHTRICEDIDECSTHSGICGPG- 1619
Query: 194 CMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECV 229
C NT G+Y C CP Y + G +C D+ + V
Sbjct: 1620 ---TCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSV 1652
Score = 55.1 bits (131), Expect = 1e-07
Identities = 60/212 (28%), Positives = 78/212 (36%), Gaps = 39/212 (18%)
Query: 113 LVGPSSVVCLPN-GTWTGEQPHCRGISECSSQP--CQNGGTCVEGVNQYRCICPPG---- 165
L+G + VC P G C +EC +QP C NG CV +RC C G
Sbjct: 2228 LIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNG-RCVNTAGSFRCDCDEGFQPS 2286
Query: 166 ---------RTGNRCQHQAQTDVN------------ECELYGQEGRPRLCMHACVNTPGS 204
R G QT EC G G C + +
Sbjct: 2287 PTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSA 2346
Query: 205 YRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEGSGNVSY 264
YR CP G A+G+ DVDEC L +C G CIN+ GSF+C C G +
Sbjct: 2347 YRKLCPHGSGYTAEGR---DVDECRMLAHLCAHG-ECINSLGSFRC---HCQAG---YTP 2396
Query: 265 VKTSPFQCERNPCPMDSRPCRHLPKTISFHYL 296
T+ + + C +PC L K +L
Sbjct: 2397 DATATTCLDMDECSQVPKPCTFLCKNTKGSFL 2428
Score = 42.7 bits (99), Expect = 6e-04
Identities = 48/173 (27%), Positives = 63/173 (36%), Gaps = 41/173 (23%)
Query: 134 CRGISECS--SQPCQNGGTCVEGVNQYRCICPPG----RTGNRCQHQAQTDVNECELYGQ 187
C + EC+ S C NG C Y C CPPG + C+ DV+EC
Sbjct: 722 CTDVDECALNSLLCDNGW-CQNSPGSYSCSCPPGFHFWQDTEICK-----DVDEC----- 770
Query: 188 EGRPRLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDE--C----------VGLQPV 234
C+ C N GSY C C G R G C D + C V LQ
Sbjct: 771 --LSSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGA 828
Query: 235 CPQGTTCINTGGSF-----QC-VSPECPEGSGNVSYVKTSPF-QCERNP--CP 278
+ C G ++ +C + P C G ++ V +CE P CP
Sbjct: 829 SLRSECCATLGAAWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCP 881
Score = 41.6 bits (96), Expect = 0.001
Identities = 35/124 (28%), Positives = 46/124 (37%), Gaps = 14/124 (11%)
Query: 102 EVHFTCNPGFRLVGPSSVVCLPNGTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCI 161
E + P F VGP G + C + PC+ C + R
Sbjct: 179 ERDYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCE---LCPAQPHPCRRG 235
Query: 162 CPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMH-ACVNTPGSYRCTCPGGYRTLADGK 220
P CQ DV+EC+ P LC +CVN GS+ C CP G+R
Sbjct: 236 FIPNIHTGACQ-----DVDECQAV-----PGLCQGGSCVNMVGSFHCRCPVGHRLSDSSA 285
Query: 221 SCED 224
+CED
Sbjct: 286 ACED 289
>gi|24430141 fibrillin 1 precursor [Homo sapiens]
Length = 2871
Score = 94.7 bits (234), Expect = 1e-19
Identities = 68/193 (35%), Positives = 84/193 (43%), Gaps = 36/193 (18%)
Query: 107 CNPGFRLVGPSSVVCLPNGTWTGEQ--PHCRG-------ISECS--SQPCQNGGTCVEGV 155
C G R GP +C GT ++ PH RG I EC C+NG CV
Sbjct: 2364 CCDGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMTNGADIDECKVIHDVCRNG-ECVNDR 2422
Query: 156 NQYRCICPPGRT----GNRCQHQAQTDVNECELYGQEGRPRLCMHACVNTPGSYRCTCPG 211
Y CIC G T G C D+NEC P+ C C NT GSY+C+CP
Sbjct: 2423 GSYHCICKTGYTPDITGTSC-----VDLNECNQ-----APKPCNFICKNTEGSYQCSCPK 2472
Query: 212 GYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEGSGNVSYVKTSPFQ 271
GY DG+SC+D+DEC Q C C+NT G F C +CP G + +
Sbjct: 2473 GYILQEDGRSCKDLDECATKQHNCQ--FLCVNTIGGFTC---KCPPG-----FTQHHTSC 2522
Query: 272 CERNPCPMDSRPC 284
+ N C D C
Sbjct: 2523 IDNNECTSDINLC 2535
Score = 92.0 bits (227), Expect = 8e-19
Identities = 52/151 (34%), Positives = 74/151 (49%), Gaps = 11/151 (7%)
Query: 103 VHFTCNPGFRLVGPSSVVCLPN-GTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCI 161
V + C G + P S C N G + C + EC PC GG C+ Y C
Sbjct: 456 VRYLCQNGRCIPTPGSCRCECNKGFQLDLRGECIDVDECEKNPCA-GGECINNQGSYTCQ 514
Query: 162 CPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMHA-CVNTPGSYRCTCPGGYRTLADGK 220
C G + + + D++EC G R+C + C+NT GS+ C C G+ DGK
Sbjct: 515 CRAGYQSTLTRTECR-DIDECLQNG-----RICNNGRCINTDGSFHCVCNAGFHVTRDGK 568
Query: 221 SCEDVDECVGLQPVCPQGTTCINTGGSFQCV 251
+CED+DEC ++ +C G CIN GSF+C+
Sbjct: 569 NCEDMDEC-SIRNMCLNG-MCINEDGSFKCI 597
Score = 89.0 bits (219), Expect = 7e-18
Identities = 58/168 (34%), Positives = 76/168 (45%), Gaps = 18/168 (10%)
Query: 118 SVVCLPNGTWTGEQPHCRGISECSS--QPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQA 175
S C + W G+ C + ECS+ C C + YRC+C G TG+
Sbjct: 1345 SFKCSCSPGWIGDGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEGYTGDGF---T 1401
Query: 176 QTDVNECELYGQEGRPRLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPV 234
TD++EC LC + C+N PG YRC C G+ ADGK+CED+DEC L +
Sbjct: 1402 CTDLDECS-----ENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDEC-SLPNI 1455
Query: 235 CPQGTTCINTGGSFQC---VSPECPEGSGNVSYVK--TSPFQCERNPC 277
C G TC N G F+C + E GN + V P C C
Sbjct: 1456 CVFG-TCHNLPGLFRCECEIGYELDRSGGNCTDVNECLDPTTCISGNC 1502
Score = 85.9 bits (211), Expect = 6e-17
Identities = 54/133 (40%), Positives = 66/133 (49%), Gaps = 25/133 (18%)
Query: 134 CRGISECSS---QPCQNGGTCVEGVNQYRCICPPGRT----GNRCQHQAQTDVNECELYG 186
C + EC+S C+NG C+ V ++C C G G C D+NEC L
Sbjct: 1928 CIDVDECASGNGNLCRNG-QCINTVGSFQCQCNEGYEVAPDGRTC-----VDINECLL-- 1979
Query: 187 QEGRPRLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTG 245
PR C C N GSYRC CP GY + CED+DECV +C G TC NT
Sbjct: 1980 ---EPRKCAPGTCQNLDGSYRCICPPGYSL--QNEKCEDIDECVEEPEICALG-TCSNTE 2033
Query: 246 GSFQCVSPECPEG 258
GSF+C+ CPEG
Sbjct: 2034 GSFKCL---CPEG 2043
Score = 83.6 bits (205), Expect = 3e-16
Identities = 51/149 (34%), Positives = 69/149 (46%), Gaps = 18/149 (12%)
Query: 114 VGPSSVVCLPNGTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPPG---RTGNR 170
VG +C +Q C I+EC C NG TC + + C C G N
Sbjct: 1869 VGSFYCLCHTGFKTNDDQTMCLDINECERDACGNG-TCRNTIGSFNCRCNHGFILSHNND 1927
Query: 171 CQHQAQTDVNECELYGQEGRPRLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECV 229
C DV+EC G LC + C+NT GS++C C GY DG++C D++EC+
Sbjct: 1928 C-----IDVDECA----SGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINECL 1978
Query: 230 GLQPVCPQGTTCINTGGSFQCVSPECPEG 258
C G TC N GS++C+ CP G
Sbjct: 1979 LEPRKCAPG-TCQNLDGSYRCI---CPPG 2003
Score = 82.4 bits (202), Expect = 6e-16
Identities = 52/158 (32%), Positives = 75/158 (47%), Gaps = 14/158 (8%)
Query: 134 CRGISECSSQP--CQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRP 191
C ++EC P C +G TC + C C G +G + + TD+NECE+ G
Sbjct: 1278 CVDVNECDLNPNICLSG-TCENTKGSFICHCDMGYSGKKGKTGC-TDINECEI----GAH 1331
Query: 192 RLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQC 250
HA C NT GS++C+C G+ + DG C D+DEC +C Q C NT GS++C
Sbjct: 1332 NCGKHAVCTNTAGSFKCSCSPGW--IGDGIKCTDLDECSNGTHMCSQHADCKNTMGSYRC 1389
Query: 251 VSPECPEGSGNVSYVKTSPFQCERNPCPMDSRPCRHLP 288
+ C EG + T +C N + C + P
Sbjct: 1390 L---CKEGYTGDGFTCTDLDECSENLNLCGNGQCLNAP 1424
Score = 81.6 bits (200), Expect = 1e-15
Identities = 53/142 (37%), Positives = 63/142 (44%), Gaps = 14/142 (9%)
Query: 113 LVGPSSVVCLPNGTWTGEQPHCRGISECSSQPCQNGGT---CVEGVNQYRCICPPGRTGN 169
L+G C P T ++ C I ECS NGG C Y C C PG
Sbjct: 1174 LIGKYQCACNPGYHSTPDRLFCVDIDECS---IMNGGCETFCTNSEGSYECSCQPGFALM 1230
Query: 170 RCQHQAQTDVNECELYGQEGRPRLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDEC 228
Q TD++EC E P +C C N PG YRC C G+ D K+C DV+EC
Sbjct: 1231 PDQRSC-TDIDEC-----EDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNEC 1284
Query: 229 VGLQPVCPQGTTCINTGGSFQC 250
+C G TC NT GSF C
Sbjct: 1285 DLNPNICLSG-TCENTKGSFIC 1305
Score = 80.1 bits (196), Expect = 3e-15
Identities = 61/201 (30%), Positives = 83/201 (41%), Gaps = 40/201 (19%)
Query: 102 EVHFTCNPG--FRLVGPSSVVCLPNGTWTGEQPHCRGISECSSQP-CQNGGTCVEGVNQY 158
E+ C G +VG C + + C I EC + P CQ C+ Y
Sbjct: 1772 EIPGVCENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNAECINTAGSY 1831
Query: 159 RCICPPG---RTGNRCQHQAQTDVNECELYGQEGRPRLCMHA-CVNTPGSYRCTCPGGYR 214
RC C PG + +C D NEC+ P +C H C++T GS+ C C G++
Sbjct: 1832 RCDCKPGYRFTSTGQCN-----DRNECQEI-----PNICSHGQCIDTVGSFYCLCHTGFK 1881
Query: 215 TLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVS---------------PECPEGS 259
T D C D++EC + C G TC NT GSF C EC G+
Sbjct: 1882 TNDDQTMCLDINECE--RDACGNG-TCRNTIGSFNCRCNHGFILSHNNDCIDVDECASGN 1938
Query: 260 GNV----SYVKT-SPFQCERN 275
GN+ + T FQC+ N
Sbjct: 1939 GNLCRNGQCINTVGSFQCQCN 1959
Score = 79.3 bits (194), Expect = 5e-15
Identities = 46/133 (34%), Positives = 60/133 (45%), Gaps = 10/133 (7%)
Query: 121 CLPNGTWTGEQPHCRGISECSSQP--CQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTD 178
C P +Q C I EC P C +GG C +YRC+C G + + D
Sbjct: 1223 CQPGFALMPDQRSCTDIDECEDNPNIC-DGGQCTNIPGEYRCLCYDGFMASE-DMKTCVD 1280
Query: 179 VNECELYGQEGRPRLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQ 237
VNEC+L P +C+ C NT GS+ C C GY C D++EC C +
Sbjct: 1281 VNECDL-----NPNICLSGTCENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGK 1335
Query: 238 GTTCINTGGSFQC 250
C NT GSF+C
Sbjct: 1336 HAVCTNTAGSFKC 1348
Score = 79.0 bits (193), Expect = 7e-15
Identities = 66/214 (30%), Positives = 79/214 (36%), Gaps = 33/214 (15%)
Query: 72 VGPDALPVSCPALNTPADGRKFGSKYLVDHEVHFTCNPGFRLVGPSSVVCLPNGTWTGEQ 131
VGPD V P D K G D C G+ L G
Sbjct: 2119 VGPDDSAVDMDECKEP-DVCKHGQCINTDGSYRCECPFGYILAGNE-------------- 2163
Query: 132 PHCRGISECS-SQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGR 190
C ECS PC NG TC + + C C G D+NEC
Sbjct: 2164 --CVDTDECSVGNPCGNG-TCKNVIGGFECTCEEGFEPGPMM--TCEDINECAQ-----N 2213
Query: 191 PRLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDEC-VGLQPVCPQGTTCINTGGSFQ 249
P LC CVNT GSY C CP GY D + C+D DEC G + C N G++
Sbjct: 2214 PLLCAFRCVNTYGSYECKCPVGYVLREDRRMCKDEDECEEGKHDCTEKQMECKNLIGTYM 2273
Query: 250 CVS----PECPEGSGNV--SYVKTSPFQCERNPC 277
C+ P+G G V + +T P CE C
Sbjct: 2274 CICGPGYQRRPDGEGCVDENECQTKPGICENGRC 2307
Score = 77.8 bits (190), Expect = 2e-14
Identities = 47/129 (36%), Positives = 62/129 (48%), Gaps = 20/129 (15%)
Query: 134 CRGISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNEC----ELYGQEG 189
C+ + EC+++ CV + + C CPPG T + H + D NEC L G +G
Sbjct: 2483 CKDLDECATKQHNCQFLCVNTIGGFTCKCPPGFTQH---HTSCIDNNECTSDINLCGSKG 2539
Query: 190 RPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQ 249
C NTPGS+ C C G+ G SCEDVDEC G C G C N G ++
Sbjct: 2540 -------ICQNTPGSFTCECQRGFSLDQTGSSCEDVDECEG-NHRCQHG--CQNIIGGYR 2589
Query: 250 CVSPECPEG 258
C CP+G
Sbjct: 2590 C---SCPQG 2595
Score = 76.6 bits (187), Expect = 4e-14
Identities = 43/132 (32%), Positives = 69/132 (52%), Gaps = 24/132 (18%)
Query: 134 CRGISEC--SSQPCQNGGTCVEGVNQYRCICPPG----RTGNRCQHQAQTDVNECELYGQ 187
CR I EC + + C NG C+ + C+C G R G C+ D++EC +
Sbjct: 528 CRDIDECLQNGRICNNG-RCINTDGSFHCVCNAGFHVTRDGKNCE-----DMDECSIRN- 580
Query: 188 EGRPRLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGG 246
+C++ C+N GS++C C G++ +DG+ C+D++EC +C G C+NT G
Sbjct: 581 -----MCLNGMCINEDGSFKCICKPGFQLASDGRYCKDINEC-ETPGICMNG-RCVNTDG 633
Query: 247 SFQCVSPECPEG 258
S++C EC G
Sbjct: 634 SYRC---ECFPG 642
Score = 76.6 bits (187), Expect = 4e-14
Identities = 52/178 (29%), Positives = 77/178 (43%), Gaps = 15/178 (8%)
Query: 121 CLPNGTWTGEQPHCRGISEC--SSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTD 178
C P + C I+EC S+ C NG CV + +Y+C C PG D
Sbjct: 1140 CPPGHQLSPNISACIDINECELSAHLCPNG-RCVNLIGKYQCACNPGYHSTP-DRLFCVD 1197
Query: 179 VNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQG 238
++EC + C C N+ GSY C+C G+ + D +SC D+DEC +C G
Sbjct: 1198 IDECSIMNGG-----CETFCTNSEGSYECSCQPGFALMPDQRSCTDIDECEDNPNIC-DG 1251
Query: 239 TTCINTGGSFQCVSPECPEGSGNVSYVKT--SPFQCERNPCPMDSRPCRHLPKTISFH 294
C N G ++C+ C +G +KT +C+ NP S C + + H
Sbjct: 1252 GQCTNIPGEYRCL---CYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTKGSFICH 1306
Score = 75.1 bits (183), Expect = 1e-13
Identities = 60/213 (28%), Positives = 83/213 (38%), Gaps = 27/213 (12%)
Query: 59 KSRLAALQNSVGRVGPDALPVSCPALNTPA------DGRKFGSKYLVDHEVHFT------ 106
+ R+ A SVG CP NTP G F +K + + + F
Sbjct: 974 RHRMDACCCSVGAAWGTEECEECPMRNTPEYEELCPRGPGFATKEITNGKPFFKDINECK 1033
Query: 107 -----CNPGF--RLVGPSSVVCLPNGTWTGEQPHCRGISECSSQPCQNG-GTCVEGVNQY 158
C G +G C E+ +C I EC P G G CV +
Sbjct: 1034 MIPSLCTHGKCRNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLCGRGQCVNTPGDF 1093
Query: 159 RCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMHA-CVNTPGSYRCTCPGGYRTLA 217
C C G + D++EC+ P LC C NT GSYRC CP G++
Sbjct: 1094 ECKCDEGYESGFMMMKNCMDIDECQR-----DPLLCRGGVCHNTEGSYRCECPPGHQLSP 1148
Query: 218 DGKSCEDVDECVGLQPVCPQGTTCINTGGSFQC 250
+ +C D++EC +CP G C+N G +QC
Sbjct: 1149 NISACIDINECELSAHLCPNG-RCVNLIGKYQC 1180
Score = 74.7 bits (182), Expect = 1e-13
Identities = 50/143 (34%), Positives = 71/143 (49%), Gaps = 18/143 (12%)
Query: 128 TGEQPHCRGISECSSQP--CQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELY 185
T +P + I+EC P C +G C + ++C C G + + TD++EC +
Sbjct: 1020 TNGKPFFKDINECKMIPSLCTHG-KCRNTIGSFKCRCDSGFALDSEERNC-TDIDECRI- 1076
Query: 186 GQEGRPRLCMHA-CVNTPGSYRCTCPGGYRT-LADGKSCEDVDECVGLQPVCPQGTTCIN 243
P LC CVNTPG + C C GY + K+C D+DEC P+ +G C N
Sbjct: 1077 ----SPDLCGRGQCVNTPGDFECKCDEGYESGFMMMKNCMDIDECQR-DPLLCRGGVCHN 1131
Query: 244 TGGSFQCVSPECPEG---SGNVS 263
T GS++C ECP G S N+S
Sbjct: 1132 TEGSYRC---ECPPGHQLSPNIS 1151
Score = 74.3 bits (181), Expect = 2e-13
Identities = 53/130 (40%), Positives = 63/130 (48%), Gaps = 24/130 (18%)
Query: 137 ISECSSQP--CQNGGTCVEGVNQYRCICPPG----RTGNRCQHQAQTDVNECELYGQEGR 190
I+EC+ P C NG C Y+CIC G TG C D+NEC L
Sbjct: 724 INECALDPDICPNG-ICENLRGTYKCICNSGYEVDSTGKNC-----VDINECVL-----N 772
Query: 191 PRLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQ 249
LC + C NTPGS+ CTCP G+ D K+CED+DEC C G C N+ GSF
Sbjct: 773 SLLCDNGQCRNTPGSFVCTCPKGFIYKPDLKTCEDIDECE--SSPCING-VCKNSPGSFI 829
Query: 250 CVSPECPEGS 259
C EC S
Sbjct: 830 C---ECSSES 836
Score = 71.2 bits (173), Expect = 1e-12
Identities = 45/127 (35%), Positives = 59/127 (46%), Gaps = 16/127 (12%)
Query: 134 CRGISECS-SQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPR 192
C + EC + CQ+G C + YRC CP G + +Q D NEC
Sbjct: 2565 CEDVDECEGNHRCQHG--CQNIIGGYRCSCPQGYLQHYQWNQC-VDENECL------SAH 2615
Query: 193 LCMHA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCV 251
+C A C NT GSY+C CP G++ C+D++EC Q C G C NT G + C
Sbjct: 2616 ICGGASCHNTLGSYKCMCPAGFQYEQFSGGCQDINECGSAQAPCSYG--CSNTEGGYLC- 2672
Query: 252 SPECPEG 258
CP G
Sbjct: 2673 --GCPPG 2677
Score = 70.9 bits (172), Expect = 2e-12
Identities = 48/159 (30%), Positives = 63/159 (39%), Gaps = 40/159 (25%)
Query: 100 DHEVHFTCNPGFRLVGPSSVVCLPNGTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYR 159
D H CN GF + T + +C + ECS + G C+ ++
Sbjct: 550 DGSFHCVCNAGFHV--------------TRDGKNCEDMDECSIRNMCLNGMCINEDGSFK 595
Query: 160 CICPPG----RTGNRCQHQAQTDVNECELYGQEGRPRLCMHA-CVNTPGSYRCTCPGGYR 214
CIC PG G C+ D+NECE P +CM+ CVNT GSYRC C G
Sbjct: 596 CICKPGFQLASDGRYCK-----DINECET------PGICMNGRCVNTDGSYRCECFPGLA 644
Query: 215 TLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSP 253
DG+ C D +TC QC+ P
Sbjct: 645 VGLDGRVCVDTH----------MRSTCYGGYKRGQCIKP 673
Score = 65.9 bits (159), Expect = 6e-11
Identities = 34/94 (36%), Positives = 51/94 (54%), Gaps = 10/94 (10%)
Query: 134 CRGISECSSQPCQNG-GTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPR 192
C I+EC +P + GTC YRCICPPG + Q++ D++EC P
Sbjct: 1971 CVDINECLLEPRKCAPGTCQNLDGSYRCICPPGYS---LQNEKCEDIDECV-----EEPE 2022
Query: 193 LC-MHACVNTPGSYRCTCPGGYRTLADGKSCEDV 225
+C + C NT GS++C CP G+ + G+ C+D+
Sbjct: 2023 ICALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDL 2056
Score = 65.1 bits (157), Expect = 1e-10
Identities = 39/101 (38%), Positives = 52/101 (51%), Gaps = 16/101 (15%)
Query: 159 RCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMHA-CVNTPGSYRCTCPGGYRTLA 217
R P RTG CQ DV+EC+ P LC C+NT GS+ C CP G++
Sbjct: 233 RGFIPNIRTG-ACQ-----DVDECQAI-----PGLCQGGNCINTVGSFECKCPAGHKLNE 281
Query: 218 DGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEG 258
+ CED+DEC + +C +G C NT S+ C +CP G
Sbjct: 282 VSQKCEDIDECSTIPGIC-EGGECTNTVSSYFC---KCPPG 318
Score = 64.7 bits (156), Expect = 1e-10
Identities = 35/95 (36%), Positives = 46/95 (48%), Gaps = 10/95 (10%)
Query: 134 CRGISECSSQP--CQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRP 191
C+ + EC + P CQ GG C+ V + C CP G N + + D++EC P
Sbjct: 244 CQDVDECQAIPGLCQ-GGNCINTVGSFECKCPAGHKLNEVSQKCE-DIDECSTI-----P 296
Query: 192 RLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCEDV 225
+C C NT SY C CP G+ T DG C DV
Sbjct: 297 GICEGGECTNTVSSYFCKCPPGFYTSPDGTRCIDV 331
Score = 63.2 bits (152), Expect = 4e-10
Identities = 41/124 (33%), Positives = 61/124 (49%), Gaps = 15/124 (12%)
Query: 134 CRGISECSSQPCQNGGTC-VEGVNQYRCICPPGRTGNRCQHQAQT--DVNECELYGQEGR 190
C + + PC+ C ++Y+ +CP G G R D++EC+
Sbjct: 1563 CCSLGKAWGTPCE---MCPAVNTSEYKILCPGGE-GFRPNPITVILEDIDECQEL----- 1613
Query: 191 PRLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQ 249
P LC C+NT GS++C CP GY D + C+DV+EC +C G TC NT G++
Sbjct: 1614 PGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNEC-ETPGICGPG-TCYNTVGNYT 1671
Query: 250 CVSP 253
C+ P
Sbjct: 1672 CICP 1675
Score = 61.6 bits (148), Expect = 1e-09
Identities = 55/198 (27%), Positives = 78/198 (39%), Gaps = 35/198 (17%)
Query: 110 GFRLVGPSSVVCLPNGTWTGEQPHCRG--ISECSSQP-----CQNGGTCVEGVNQYRCIC 162
G R + ++ C+ G+ + + C+ I QP C NGG CV RC C
Sbjct: 112 GSRSIQHCNIRCMNGGSCSDDHCLCQKGYIGTHCGQPVCESGCLNGGRCVA---PNRCAC 168
Query: 163 PPGRTGNRCQHQAQT---------DVNECELYGQEGRPRLCM--------HACVNTPGSY 205
G TG +C+ +T + + +L G LC H C P
Sbjct: 169 TYGFTGPQCERDYRTGPCFTVISNQMCQGQLSGIVCTKTLCCATVGRAWGHPCEMCPAQP 228
Query: 206 RCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSP------ECPEGS 259
C G+ +C+DVDEC + +C QG CINT GSF+C P E +
Sbjct: 229 H-PCRRGFIPNIRTGACQDVDECQAIPGLC-QGGNCINTVGSFECKCPAGHKLNEVSQKC 286
Query: 260 GNVSYVKTSPFQCERNPC 277
++ T P CE C
Sbjct: 287 EDIDECSTIPGICEGGEC 304
Score = 59.7 bits (143), Expect = 4e-09
Identities = 52/160 (32%), Positives = 64/160 (40%), Gaps = 41/160 (25%)
Query: 133 HCRGISECSSQPCQNGGTCVEGVNQYRCICPPG-------------RTGN---------- 169
+C ++EC G CV Y C CPP R+GN
Sbjct: 1484 NCTDVNECLDPTTCISGNCVNTPGSYICDCPPDFELNPTRVGCVDTRSGNCYLDIRPRGD 1543
Query: 170 ----RCQHQAQTDVNE----CELYGQEGRPRLC-MHACVNTPGSYRCTCPG--GYRTLAD 218
C ++ V++ C L G P C M VNT Y+ CPG G+R
Sbjct: 1544 NGDTACSNEIGVGVSKASCCCSLGKAWGTP--CEMCPAVNT-SEYKILCPGGEGFRPNPI 1600
Query: 219 GKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEG 258
ED+DEC L +C QG CINT GSFQC CP G
Sbjct: 1601 TVILEDIDECQELPGLC-QGGKCINTFGSFQC---RCPTG 1636
Score = 57.8 bits (138), Expect = 2e-08
Identities = 52/171 (30%), Positives = 71/171 (41%), Gaps = 25/171 (14%)
Query: 107 CNPGFRLVGPSSVVCL-PNG-TWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPP 164
C+ G P S VC P G + + C I EC S PC N G C + C C
Sbjct: 776 CDNGQCRNTPGSFVCTCPKGFIYKPDLKTCEDIDECESSPCIN-GVCKNSPGSFICECSS 834
Query: 165 GRTGNRCQHQA-QTDVNECELYGQEGRPRLCMHA------CVNTPGS---YRCT------ 208
T + + +T C +GR + ++ C ++ G+ CT
Sbjct: 835 ESTLDPTKTICIETIKGTCWQTVIDGRCEININGATLKSQCCSSLGAAWGSPCTLCQVDP 894
Query: 209 -CPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEG 258
C GY + G CED+DEC VC G C+NT GSF+C +CP G
Sbjct: 895 ICGKGYSRI-KGTQCEDIDECEVFPGVCKNG-LCVNTRGSFKC---QCPSG 940
Score = 57.8 bits (138), Expect = 2e-08
Identities = 36/108 (33%), Positives = 47/108 (43%), Gaps = 11/108 (10%)
Query: 137 ISECSSQP--CQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLC 194
I EC P CQ GG C+ ++C CP G N + DVNECE P +C
Sbjct: 1607 IDECQELPGLCQ-GGKCINTFGSFQCRCPTGYYLNE-DTRVCDDVNECET------PGIC 1658
Query: 195 -MHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTC 241
C NT G+Y C CP Y + G +C D+ + + TC
Sbjct: 1659 GPGTCYNTVGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTC 1706
Score = 55.5 bits (132), Expect = 8e-08
Identities = 30/86 (34%), Positives = 39/86 (45%), Gaps = 6/86 (6%)
Query: 134 CRGISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRL 193
C +EC S G +C + Y+C+CP G + Q D+NEC G P
Sbjct: 2605 CVDENECLSAHICGGASCHNTLGSYKCMCPAGFQYEQFSGGCQ-DINEC---GSAQAP-- 2658
Query: 194 CMHACVNTPGSYRCTCPGGYRTLADG 219
C + C NT G Y C CP GY + G
Sbjct: 2659 CSYGCSNTEGGYLCGCPPGYFRIGQG 2684
Score = 54.3 bits (129), Expect = 2e-07
Identities = 42/122 (34%), Positives = 48/122 (39%), Gaps = 20/122 (16%)
Query: 134 CRGISECSSQPCQNGGTCVEGVNQYRCICPPG----RTGNRCQHQAQTDVNECELYGQEG 189
C I ECS GTC +RC C G R+G C TDVNEC
Sbjct: 1444 CEDIDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNC-----TDVNECL------ 1492
Query: 190 RPRLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQG----TTCINT 244
P C+ CVNTPGSY C CP + C D + P+G T C N
Sbjct: 1493 DPTTCISGNCVNTPGSYICDCPPDFELNPTRVGCVDTRSGNCYLDIRPRGDNGDTACSNE 1552
Query: 245 GG 246
G
Sbjct: 1553 IG 1554
Score = 52.0 bits (123), Expect = 9e-07
Identities = 52/180 (28%), Positives = 76/180 (42%), Gaps = 47/180 (26%)
Query: 140 CSSQPCQNGGTCVEGVNQYRCICPPGRT---GNRCQHQAQTDVNECELYGQEGRPRLCMH 196
CSS G C + Q IC G + G +C+ D++ECE++ P +C +
Sbjct: 876 CSSLGAAWGSPCT--LCQVDPICGKGYSRIKGTQCE-----DIDECEVF-----PGVCKN 923
Query: 197 A-CVNTPGSYRCTCPGGYRTLADGKSCEDV-----------DECVGLQPVCPQ---GTTC 241
CVNT GS++C CP G A G+ C D+ +EC P+ + C
Sbjct: 924 GLCVNTRGSFKCQCPSGMTLDATGRICLDIRLETCFLRYEDEECT--LPIAGRHRMDACC 981
Query: 242 INTG---GSFQCV------SPE----CPEGSGNVSYVKTS--PFQCERNPCPMDSRPCRH 286
+ G G+ +C +PE CP G G + T+ PF + N C M C H
Sbjct: 982 CSVGAAWGTEECEECPMRNTPEYEELCPRGPGFATKEITNGKPFFKDINECKMIPSLCTH 1041
Score = 51.6 bits (122), Expect = 1e-06
Identities = 49/171 (28%), Positives = 63/171 (36%), Gaps = 43/171 (25%)
Query: 123 PNGTWTGEQPH-CRGISECSSQPCQNGGTCVEGVNQYRCICPPG----RTGNRCQHQAQT 177
P G + E C ++EC + GTC V Y CICPP GN C ++
Sbjct: 1634 PTGYYLNEDTRVCDDVNECETPGICGPGTCYNTVGNYTCICPPDYMQVNGGNNCMDMRRS 1693
Query: 178 --------DVNECE---LYGQEGRPRLCMH--------ACVNTP-----------GSYRC 207
D C+ L+ + C + C P GS R
Sbjct: 1694 LCYRNYYADNQTCDGELLFNMTKKMCCCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQR- 1752
Query: 208 TCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEG 258
PG + G D+DEC + VC G CIN GSF+C ECP G
Sbjct: 1753 --PGFVIDIYTGLPV-DIDECREIPGVCENG-VCINMVGSFRC---ECPVG 1796
Score = 51.6 bits (122), Expect = 1e-06
Identities = 39/126 (30%), Positives = 54/126 (42%), Gaps = 14/126 (11%)
Query: 151 CVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMHA-CVNTPGSYRCTC 209
C + Y CIC PG R + D NEC+ +P +C + C+NT GSY C C
Sbjct: 2265 CKNLIGTYMCICGPGYQ-RRPDGEGCVDENECQT-----KPGICENGRCLNTRGSYTCEC 2318
Query: 210 PGGYRTLADGKSCEDVDE--CVG--LQPVCPQGTTCINTGGSFQCVSPECPEGSGNVSYV 265
G+ + C D E C LQ +C G++ N +C C G G +
Sbjct: 2319 NDGFTASPNQDECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECC---CDGGRGWGPHC 2375
Query: 266 KTSPFQ 271
+ PFQ
Sbjct: 2376 EICPFQ 2381
>gi|66346695 fibrillin 2 precursor [Homo sapiens]
Length = 2912
Score = 94.7 bits (234), Expect = 1e-19
Identities = 65/190 (34%), Positives = 84/190 (44%), Gaps = 27/190 (14%)
Query: 102 EVHFTCNPGF--RLVGPSSVVCLPNGTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYR 159
E+ C+ G L G +C + +Q C + EC PC NG TC V Y
Sbjct: 1898 EIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECERHPCGNG-TCKNTVGSYN 1956
Query: 160 CICPPG---RTGNRCQHQAQTDVNECE-LYGQEGRPRLCMHA-CVNTPGSYRCTCPGGYR 214
C+C PG N C D++EC +GQ +C + C N GS++C C GY
Sbjct: 1957 CLCYPGFELTHNNDC-----LDIDECSSFFGQ-----VCRNGRCFNEIGSFKCLCNEGYE 2006
Query: 215 TLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEGSGNVSYVKTSPFQCER 274
DGK+C D +ECV L C G TC N GSF+C+ CP G Y S +
Sbjct: 2007 LTPDGKNCIDTNECVALPGSCSPG-TCQNLEGSFRCI---CPPG-----YEVKSENCIDI 2057
Query: 275 NPCPMDSRPC 284
N C D C
Sbjct: 2058 NECDEDPNIC 2067
Score = 91.7 bits (226), Expect = 1e-18
Identities = 60/156 (38%), Positives = 73/156 (46%), Gaps = 24/156 (15%)
Query: 134 CRGISECS-SQPCQNGGTCVEGVNQYRCIC----PPGRTGNRCQHQAQTDVNECELYGQE 188
C ECS PC NG TC + + C C PG N C+ D+NEC
Sbjct: 2211 CVDTDECSIGNPCGNG-TCTNVIGSFECNCNEGFEPGPMMN-CE-----DINECAQ---- 2259
Query: 189 GRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECV-GLQPVCPQGTTCINTGGS 247
P LC C+NT GSY CTCP GY D K C+D+DEC GL +G C N G+
Sbjct: 2260 -NPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGT 2318
Query: 248 FQCVSP----ECPEGSGNV--SYVKTSPFQCERNPC 277
F C+ P P+G G V + +T P CE C
Sbjct: 2319 FMCICPPGMARRPDGEGCVDENECRTKPGICENGRC 2354
Score = 89.7 bits (221), Expect = 4e-18
Identities = 53/160 (33%), Positives = 77/160 (48%), Gaps = 15/160 (9%)
Query: 133 HCRGISECSSQPCQ-NGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRP 191
+C I EC P GGTCV ++C CP G + + D+NEC L
Sbjct: 1155 NCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDC-VDINECSL-----SD 1208
Query: 192 RLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQC 250
LC + CVN G+Y+C+C GY+ D + C D+DEC+ + C T C N+ GS++C
Sbjct: 1209 NLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCD--TQCTNSEGSYEC 1266
Query: 251 VSPECPEGSGNVSYVKTSPF--QCERNPCPMDSRPCRHLP 288
C EG + ++ +CE NP D C ++P
Sbjct: 1267 ---SCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIP 1303
Score = 87.8 bits (216), Expect = 2e-17
Identities = 51/130 (39%), Positives = 65/130 (50%), Gaps = 22/130 (16%)
Query: 135 RGISECSSQP--CQNGGTCVEGVNQYRCICPPGRT----GNRCQHQAQTDVNECELYGQE 188
R I EC P C NG C+ + +RC C G T G C D++EC
Sbjct: 2448 RDIDECKVMPNLCTNG-QCINTMGSFRCFCKVGYTTDISGTSC-----IDLDECSQ---- 2497
Query: 189 GRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSF 248
P+ C + C NT GSY+C+CP GY DGK+C+D+DEC Q C C+NT G F
Sbjct: 2498 -SPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQ--FLCVNTLGGF 2554
Query: 249 QCVSPECPEG 258
C +CP G
Sbjct: 2555 TC---KCPPG 2561
Score = 87.4 bits (215), Expect = 2e-17
Identities = 56/170 (32%), Positives = 73/170 (42%), Gaps = 18/170 (10%)
Query: 116 PSSVVCLPNGTWTGEQPHCRGISECSS--QPCQNGGTCVEGVNQYRCICPPGRTGNRCQH 173
P S C W G C + ECS+ C CV YRC C G TG+
Sbjct: 1388 PGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGF-- 1445
Query: 174 QAQTDVNECELYGQEGRPRLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQ 232
+DV+EC LC + C+N PG+YRC C G+ +D +SC+D+DEC Q
Sbjct: 1446 -TCSDVDECA-----ENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDEC-SFQ 1498
Query: 233 PVCPQGTTCINTGGSFQCVSP---ECPEGSGNVSYVK--TSPFQCERNPC 277
+C G TC N G F C+ E GN + + P C C
Sbjct: 1499 NICVFG-TCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCVNGLC 1547
Score = 86.7 bits (213), Expect = 3e-17
Identities = 52/153 (33%), Positives = 73/153 (47%), Gaps = 16/153 (10%)
Query: 134 CRGISECSSQP--CQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRP 191
C I+ECS C+NG CV + Y+C C PG Q TD++EC +
Sbjct: 1198 CVDINECSLSDNLCRNG-KCVNMIGTYQCSCNPGYQATP-DRQGCTDIDECMIMNGG--- 1252
Query: 192 RLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCV 251
C C N+ GSY C+C GY + DG+SC D+DEC +C G C N G ++C+
Sbjct: 1253 --CDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDIC-DGGQCTNIPGEYRCL 1309
Query: 252 SPECPEGSGNVSYVKTSPFQCERNPCPMDSRPC 284
C +G +KT + N C ++S C
Sbjct: 1310 ---CYDGFMASMDMKTC---IDVNECDLNSNIC 1336
Score = 83.6 bits (205), Expect = 3e-16
Identities = 50/121 (41%), Positives = 63/121 (52%), Gaps = 14/121 (11%)
Query: 134 CRGISECSSQPCQNGGTCVEGVNQYRCICPPG--RTGNRCQHQAQTDVNECELYGQEGRP 191
C + EC+S PC NG CV Y C C G RT + QA D++EC G
Sbjct: 533 CIDVDECTSNPCTNGD-CVNTPGSYYCKCHAGFQRTPTK---QACIDIDECIQNGV---- 584
Query: 192 RLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQC 250
LC + CVNT GS++C C G+ DGK+C D DEC +C G CIN GSF+C
Sbjct: 585 -LCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTN-MCLNG-MCINEDGSFKC 641
Query: 251 V 251
+
Sbjct: 642 I 642
Score = 80.1 bits (196), Expect = 3e-15
Identities = 49/147 (33%), Positives = 73/147 (49%), Gaps = 18/147 (12%)
Query: 137 ISECSSQP--CQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLC 194
I EC P C NG C+ + +RC CP G + N + D++EC LC
Sbjct: 1809 IDECKEIPGICANG-VCINQIGSFRCECPTGFSYNDLLLVCE-DIDECS-----NGDNLC 1861
Query: 195 MHA--CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVS 252
C+N+PGSYRC C G++ +G +C D +EC+ + VC G C++ GS+QC+
Sbjct: 1862 QRNADCINSPGSYRCECAAGFKLSPNG-ACVDRNECLEIPNVCSHG-LCVDLQGSYQCI- 1918
Query: 253 PECPEG--SGNVSYVKTSPFQCERNPC 277
C G + + +CER+PC
Sbjct: 1919 --CHNGFKASQDQTMCMDVDECERHPC 1943
Score = 79.3 bits (194), Expect = 5e-15
Identities = 54/160 (33%), Positives = 78/160 (48%), Gaps = 18/160 (11%)
Query: 131 QPHCRGISECSSQPCQ-NGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEG 189
+P + I+EC + P G C + ++C C G + + TD++EC +
Sbjct: 1068 RPFYKDINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNC-TDIDECRI----- 1121
Query: 190 RPRLCMHA-CVNTPGSYRCTCPGGYRT-LADGKSCEDVDECVGLQPVCPQGTTCINTGGS 247
P LC CVNTPGS+ C C GY + K+C D+DEC P+ +G TC+NT GS
Sbjct: 1122 SPDLCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDECER-NPLLCRGGTCVNTEGS 1180
Query: 248 FQCVSPECPEGSGNVSYVKTSPFQC-ERNPCPMDSRPCRH 286
FQC +CP G + S C + N C + CR+
Sbjct: 1181 FQC---DCPLG----HELSPSREDCVDINECSLSDNLCRN 1213
Score = 79.0 bits (193), Expect = 7e-15
Identities = 58/193 (30%), Positives = 77/193 (39%), Gaps = 54/193 (27%)
Query: 134 CRGISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRL 193
C+ + EC ++ CV + + C CPPG T + H A D NEC +P L
Sbjct: 2530 CKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQH---HTACIDNNECG-----SQPSL 2581
Query: 194 C--MHACVNTPGSYRCTCPGGYRTLADGKSCEDVDEC--------------VGLQPVCPQ 237
C C NTPGS+ C C G+ A G +CEDVDEC G + CPQ
Sbjct: 2582 CGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQNILGGYRCGCPQ 2641
Query: 238 G------------------------TTCINTGGSFQCVSPECPEGSGNVSYVKTSPFQCE 273
G +C NT GS++C CP G S+ + S +
Sbjct: 2642 GYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCA---CPSG---FSFDQFSSACHD 2695
Query: 274 RNPCPMDSRPCRH 286
N C PC +
Sbjct: 2696 VNECSSSKNPCNY 2708
Score = 75.9 bits (185), Expect = 6e-14
Identities = 47/128 (36%), Positives = 59/128 (46%), Gaps = 13/128 (10%)
Query: 134 CRGISECSSQP--CQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRP 191
C I EC + P C +GG C +YRC+C G + + DVNEC+L
Sbjct: 1281 CADIDECENNPDIC-DGGQCTNIPGEYRCLCYDGFMASM-DMKTCIDVNECDL-----NS 1333
Query: 192 RLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQC 250
+CM C NT GS+ C C GY C DVDEC C +C+N GSF+C
Sbjct: 1334 NICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKC 1393
Query: 251 VSPECPEG 258
C EG
Sbjct: 1394 ---SCREG 1398
Score = 74.7 bits (182), Expect = 1e-13
Identities = 56/164 (34%), Positives = 71/164 (43%), Gaps = 29/164 (17%)
Query: 115 GPSSVVCLPNGTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPPG----RTGNR 170
G S C P + E C I+EC S PC N G C + + C C PG TG
Sbjct: 831 GSYSCTCPPGYVFRTETETCEDINECESNPCVN-GACRNNLGSFNCECSPGSKLSSTGLI 889
Query: 171 CQHQAQTDVNECELYGQEGRPRLCMHA------CVNTPGS------YRC----TCPGGYR 214
C + C L Q+ R + ++ C T G+ RC CP G
Sbjct: 890 CIDSLK---GTCWLNIQDSRCEVNINGATLKSECCATLGAAWGSPCERCELDTACPRGLA 946
Query: 215 TLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEG 258
+ G +CEDV+EC VCP G C+N+ GSF C ECPEG
Sbjct: 947 RI-KGVTCEDVNECEVFPGVCPNG-RCVNSKGSFHC---ECPEG 985
Score = 72.8 bits (177), Expect = 5e-13
Identities = 43/132 (32%), Positives = 60/132 (45%), Gaps = 11/132 (8%)
Query: 129 GEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECE--LYG 186
G +C I+EC+ P C+ Y C CP G Q + D++EC L+
Sbjct: 2246 GPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCK-DLDECAEGLHD 2304
Query: 187 QEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGG 246
E R +C N G++ C CP G DG+ C D +EC +C G C+N G
Sbjct: 2305 CESRGMMCK----NLIGTFMCICPPGMARRPDGEGCVDENECRTKPGICENG-RCVNIIG 2359
Query: 247 SFQCVSPECPEG 258
S++C EC EG
Sbjct: 2360 SYRC---ECNEG 2368
Score = 72.4 bits (176), Expect = 7e-13
Identities = 41/108 (37%), Positives = 56/108 (51%), Gaps = 12/108 (11%)
Query: 145 CQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMHA-CVNTPG 203
C NG C+ V+ YRC C G + + DV+EC C + CVNTPG
Sbjct: 505 CLNG-RCIPTVSSYRCECNMGYKQDA--NGDCIDVDECT-------SNPCTNGDCVNTPG 554
Query: 204 SYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCV 251
SY C C G++ ++C D+DEC+ +C G C+NT GSFQC+
Sbjct: 555 SYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNG-RCVNTDGSFQCI 601
Score = 72.4 bits (176), Expect = 7e-13
Identities = 51/132 (38%), Positives = 63/132 (47%), Gaps = 24/132 (18%)
Query: 135 RGISECSSQP--CQNGGTCVEGVNQYRCIC----PPGRTGNRCQHQAQTDVNECELYGQE 188
R I+EC+ P C NG C YRC C P +G C D++EC +
Sbjct: 767 RDINECALDPDICANG-ICENLRGSYRCNCNSGYEPDASGRNC-----IDIDECLV---- 816
Query: 189 GRPRLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGS 247
LC + C NTPGSY CTCP GY + ++CED++EC C G C N GS
Sbjct: 817 -NRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECE--SNPCVNG-ACRNNLGS 872
Query: 248 FQCVSPECPEGS 259
F C EC GS
Sbjct: 873 FNC---ECSPGS 881
Score = 72.4 bits (176), Expect = 7e-13
Identities = 46/128 (35%), Positives = 59/128 (46%), Gaps = 16/128 (12%)
Query: 133 HCRGISECS-SQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRP 191
+C + EC + CQ+G C + YRC CP G + +Q D NEC P
Sbjct: 2611 NCEDVDECDGNHRCQHG--CQNILGGYRCGCPQGYIQHYQWNQC-VDENECS------NP 2661
Query: 192 RLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQC 250
C A C NT GSY+C CP G+ +C DV+EC + C G C NT G + C
Sbjct: 2662 NACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNPCNYG--CSNTEGGYLC 2719
Query: 251 VSPECPEG 258
CP G
Sbjct: 2720 ---GCPPG 2724
Score = 72.0 bits (175), Expect = 9e-13
Identities = 51/165 (30%), Positives = 74/165 (44%), Gaps = 18/165 (10%)
Query: 99 VDHEVHFTCNPGFRLVGPSSVVCLPNGTW--TGEQPHCRGISECSSQP--CQNGGTCVEG 154
VD C G + P S C + + T + C I EC C+NG CV
Sbjct: 536 VDECTSNPCTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNG-RCVNT 594
Query: 155 VNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMHA-CVNTPGSYRCTCPGGY 213
++CIC G + TD C + + +C++ C+N GS++C C G+
Sbjct: 595 DGSFQCICNAG-------FELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGF 647
Query: 214 RTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEG 258
+G+ C DVDEC +C G CIN+ GSF+C +CP G
Sbjct: 648 VLAPNGRYCTDVDEC-QTPGICMNG-HCINSEGSFRC---DCPPG 687
Score = 72.0 bits (175), Expect = 9e-13
Identities = 49/146 (33%), Positives = 60/146 (41%), Gaps = 22/146 (15%)
Query: 113 LVGPSSVVCLPNGTWTGEQPHCRGISECSSQPCQNGGT---CVEGVNQYRCICPPGRT-- 167
++G C P T ++ C I EC NGG C Y C C G
Sbjct: 1219 MIGTYQCSCNPGYQATPDRQGCTDIDECM---IMNGGCDTQCTNSEGSYECSCSEGYALM 1275
Query: 168 --GNRCQHQAQTDVNECELYGQEGRPRLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCED 224
G C D++ECE P +C C N PG YRC C G+ D K+C D
Sbjct: 1276 PDGRSC-----ADIDECE-----NNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCID 1325
Query: 225 VDECVGLQPVCPQGTTCINTGGSFQC 250
V+EC +C G C NT GSF C
Sbjct: 1326 VNECDLNSNICMFG-ECENTKGSFIC 1350
Score = 72.0 bits (175), Expect = 9e-13
Identities = 56/174 (32%), Positives = 75/174 (43%), Gaps = 38/174 (21%)
Query: 107 CNPGFRLVGPSSVVCLPN---GTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICP 163
C P F+L P+ V C+ N + P G C+++ GV++ C C
Sbjct: 1558 CPPDFQL-NPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTE-------IGVGVSRSSCCCS 1609
Query: 164 PGRT-GNRCQHQAQTDVNECELY----GQEG------------------RPRLCMHA-CV 199
G+ GN C+ VN E Y G EG P LC C+
Sbjct: 1610 LGKAWGNPCE--TCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCI 1667
Query: 200 NTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSP 253
NT GS++C CP GY D + CED+DEC VC G TC NT G++ C+ P
Sbjct: 1668 NTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGPG-TCYNTLGNYTCICP 1720
Score = 71.2 bits (173), Expect = 1e-12
Identities = 41/123 (33%), Positives = 57/123 (46%), Gaps = 8/123 (6%)
Query: 130 EQPHCRGISECSSQPCQNG-GTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQE 188
E+ +C I EC P G G CV + C C G + D++ECE
Sbjct: 1109 EERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDECER---- 1164
Query: 189 GRPRLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGS 247
P LC CVNT GS++C CP G+ + C D++EC +C G C+N G+
Sbjct: 1165 -NPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNG-KCVNMIGT 1222
Query: 248 FQC 250
+QC
Sbjct: 1223 YQC 1225
Score = 70.5 bits (171), Expect = 3e-12
Identities = 46/132 (34%), Positives = 65/132 (49%), Gaps = 18/132 (13%)
Query: 154 GVNQYRCICPPGRT-GNRCQ----HQAQTDVNECELYGQEGRPRLCMHA-CVNTPGSYRC 207
G +Y +CP G NR D+NEC+ + P +C + C NT GS++C
Sbjct: 1044 GTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAF-----PGMCTYGKCRNTIGSFKC 1098
Query: 208 TCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEG--SGNVSYV 265
C G+ + ++C D+DEC +C G C+NT GSF+C EC EG SG +
Sbjct: 1099 RCNSGFALDMEERNCTDIDECRISPDLCGSG-ICVNTPGSFEC---ECFEGYESGFMMMK 1154
Query: 266 KTSPF-QCERNP 276
+CERNP
Sbjct: 1155 NCMDIDECERNP 1166
Score = 69.7 bits (169), Expect = 4e-12
Identities = 54/178 (30%), Positives = 77/178 (43%), Gaps = 39/178 (21%)
Query: 107 CNPGFRLVGPSSVVCLPNGTWTGEQPHCRG-------ISECSSQPCQNGGTCVEGVNQYR 159
C G R +GP+ C+ +TG P C ++ ++Q CQ T +
Sbjct: 184 CQNGGRCIGPNRCACVYG--FTG--PQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLC 239
Query: 160 C------------ICP----PGRTG--NRCQHQAQTDVNECELYGQEGRPRLCMHA-CVN 200
C +CP P R G + A DV+EC+ P +C C+N
Sbjct: 240 CATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTGACQDVDECQAI-----PGICQGGNCIN 294
Query: 201 TPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEG 258
T GS+ C CP G++ + CED+DEC + +C G C NT GS+ CV CP G
Sbjct: 295 TVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETG-ECSNTVGSYFCV---CPRG 348
Score = 68.2 bits (165), Expect = 1e-11
Identities = 46/125 (36%), Positives = 57/125 (45%), Gaps = 16/125 (12%)
Query: 140 CSSQPCQNGGTCVEGVNQ-----YRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLC 194
CS P + G E + ++ +CP G H + DVNEC P +C
Sbjct: 2128 CSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECL-----ESPGIC 2182
Query: 195 MHA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSP 253
+ C+NT GS+RC CP GY G C D DEC P C G TC N GSF+C
Sbjct: 2183 SNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNP-CGNG-TCTNVIGSFEC--- 2237
Query: 254 ECPEG 258
C EG
Sbjct: 2238 NCNEG 2242
Score = 66.6 bits (161), Expect = 4e-11
Identities = 35/94 (37%), Positives = 47/94 (50%), Gaps = 10/94 (10%)
Query: 134 CRGISECSSQP--CQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRP 191
C+ + EC + P CQ GG C+ V + C CP G + + + D++EC + P
Sbjct: 274 CQDVDECQAIPGICQ-GGNCINTVGSFECRCPAGHKQSETTQKCE-DIDECSII-----P 326
Query: 192 RLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCED 224
+C C NT GSY C CP GY T DG C D
Sbjct: 327 GICETGECSNTVGSYFCVCPRGYVTSTDGSRCID 360
Score = 66.2 bits (160), Expect = 5e-11
Identities = 41/129 (31%), Positives = 53/129 (41%), Gaps = 19/129 (14%)
Query: 134 CRGISECSSQPCQNGGTCVEGVNQYRCICPPG----RTGNRCQHQAQTDVNECELYGQEG 189
C + ECS P C Y+C CP G G C+ D++EC+
Sbjct: 2489 CIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCK-----DLDECQT----- 2538
Query: 190 RPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQ 249
+ C CVNT G + C CP G+ +C D +EC +C C NT GSF
Sbjct: 2539 KQHNCQFLCVNTLGGFTCKCPPGF--TQHHTACIDNNECGSQPSLCGAKGICQNTPGSFS 2596
Query: 250 CVSPECPEG 258
C EC G
Sbjct: 2597 C---ECQRG 2602
Score = 65.5 bits (158), Expect = 8e-11
Identities = 36/116 (31%), Positives = 56/116 (48%), Gaps = 10/116 (8%)
Query: 111 FRLVGPSSVVCLPNGTWTGEQPHCRGISECSSQPCQ-NGGTCVEGVNQYRCICPPGRTGN 169
F +G +C T + +C +EC + P + GTC +RCICPPG
Sbjct: 1991 FNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGY--- 2047
Query: 170 RCQHQAQTDVNECELYGQEGRPRLCMH-ACVNTPGSYRCTCPGGYRTLADGKSCED 224
+ + D+NEC+ P +C+ +C NTPG ++C CP G+ +G+ C D
Sbjct: 2048 EVKSENCIDINECD-----EDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFD 2098
Score = 65.1 bits (157), Expect = 1e-10
Identities = 46/153 (30%), Positives = 68/153 (44%), Gaps = 28/153 (18%)
Query: 143 QPCQNGGTCVEGVNQYRCICP--PGRTGNRCQHQAQTDVNECELYGQEGRPRLCMHA-CV 199
+PC GT ++ IC PG T + +A D++EC+ P +C + C+
Sbjct: 1777 EPCPTPGTA-----DFKTICGNIPGFTFDIHTGKA-VDIDECKEI-----PGICANGVCI 1825
Query: 200 NTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEGS 259
N GS+RC CP G+ CED+DEC +C + CIN+ GS++C EC G
Sbjct: 1826 NQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRC---ECAAG- 1881
Query: 260 GNVSYVKTSPFQCERNPCPMDSRPCRHLPKTIS 292
F+ N +D C +P S
Sbjct: 1882 ----------FKLSPNGACVDRNECLEIPNVCS 1904
Score = 64.3 bits (155), Expect = 2e-10
Identities = 46/157 (29%), Positives = 69/157 (43%), Gaps = 24/157 (15%)
Query: 130 EQPHCRGISECSS--QPCQNGGT-CVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYG 186
+Q C+ + EC+ C++ G C + + CICPPG R + D NEC
Sbjct: 2288 DQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMA-RRPDGEGCVDENECRT-- 2344
Query: 187 QEGRPRLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDE--CVG--LQPVCPQGTTC 241
+P +C + CVN GSYRC C G+++ + G C D + C LQ +C ++
Sbjct: 2345 ---KPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSS 2401
Query: 242 INTGGSFQCVSPECPEGSGNVSYVKTSPFQCERNPCP 278
N +C C +G + QCE P P
Sbjct: 2402 RNLVTKSEC----CCDGGRGWGH------QCELCPLP 2428
Score = 63.5 bits (153), Expect = 3e-10
Identities = 39/123 (31%), Positives = 54/123 (43%), Gaps = 30/123 (24%)
Query: 107 CNPGFRLVGPSSVVCLPNGTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPPG- 165
CN GF L T + +C EC++ G C+ ++CIC PG
Sbjct: 602 CNAGFEL--------------TTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGF 647
Query: 166 ---RTGNRCQHQAQTDVNECELYGQEGRPRLCMHA-CVNTPGSYRCTCPGGYRTLADGKS 221
G C TDV+EC+ P +CM+ C+N+ GS+RC CP G DG+
Sbjct: 648 VLAPNGRYC-----TDVDECQT------PGICMNGHCINSEGSFRCDCPPGLAVGMDGRV 696
Query: 222 CED 224
C D
Sbjct: 697 CVD 699
Score = 62.4 bits (150), Expect = 7e-10
Identities = 54/188 (28%), Positives = 67/188 (35%), Gaps = 41/188 (21%)
Query: 121 CLPNGTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPPG----RTGNRCQHQAQ 176
C T + C+ I ECS Q GTC + CIC G RTG C
Sbjct: 1476 CEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNC----- 1530
Query: 177 TDVNECELYGQEGRPRLCMHA-CVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVC 235
TD++EC P C++ CVNTPG Y C CP ++ G C VD VG
Sbjct: 1531 TDIDEC------ADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGC--VDNRVG----- 1577
Query: 236 PQGTTCINTGGSFQCVSPECPEGSGNVSYVKTSPFQCERNPCPMD-----SRPCRHLPKT 290
C P G G++S R+ C PC P
Sbjct: 1578 -------------NCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPV 1624
Query: 291 ISFHYLSL 298
S Y +L
Sbjct: 1625 NSTEYYTL 1632
Score = 60.1 bits (144), Expect = 3e-09
Identities = 55/211 (26%), Positives = 77/211 (36%), Gaps = 40/211 (18%)
Query: 113 LVGPSSVVCLPNGTWTGEQPHCRGISECSSQP--CQNGGTCVEGVNQYRCICPPG----R 166
L+G +C P + C +EC ++P C+NG CV + YRC C G
Sbjct: 2315 LIGTFMCICPPGMARRPDGEGCVDENECRTKPGICENG-RCVNIIGSYRCECNEGFQSSS 2373
Query: 167 TGNRCQHQAQ---------------------TDVNECELYGQEGRPRLCMHACVNTPGSY 205
+G C Q +EC G G C + Y
Sbjct: 2374 SGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQY 2433
Query: 206 RCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEGSGNVSYV 265
+ CP G DG+ D+DEC + +C G CINT GSF+C C G
Sbjct: 2434 KKICPHGPGYTTDGR---DIDECKVMPNLCTNG-QCINTMGSFRCF---CKVG----YTT 2482
Query: 266 KTSPFQC-ERNPCPMDSRPCRHLPKTISFHY 295
S C + + C +PC ++ K Y
Sbjct: 2483 DISGTSCIDLDECSQSPKPCNYICKNTEGSY 2513
Score = 58.9 bits (141), Expect = 8e-09
Identities = 56/185 (30%), Positives = 66/185 (35%), Gaps = 41/185 (22%)
Query: 106 TCNPGFRLVGPSSVVCLPNGTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPP- 164
TCN L G +C +C I EC+ G CV +Y C CPP
Sbjct: 1505 TCN---NLPGMFHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPD 1561
Query: 165 ------------GRTGN-------------RCQHQAQTDVNE----CELYGQEGRPRLCM 195
R GN C + V+ C L G P C
Sbjct: 1562 FQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNP--CE 1619
Query: 196 HACVNTPGSYRCTCPGG--YRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSP 253
Y CPGG +R ED+DEC L +C QG CINT GSFQC
Sbjct: 1620 TCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLC-QGGNCINTFGSFQC--- 1675
Query: 254 ECPEG 258
ECP+G
Sbjct: 1676 ECPQG 1680
Score = 55.5 bits (132), Expect = 8e-08
Identities = 46/169 (27%), Positives = 63/169 (37%), Gaps = 51/169 (30%)
Query: 135 RGISECSSQPCQNGGTCVEG----------------------------VNQYRCICPPGR 166
+ I +CS + C NGGTC + + RC C G
Sbjct: 144 KSIQQCSVR-CMNGGTCADDHCQCQKGYIGTYCGQPVCENGCQNGGRCIGPNRCACVYGF 202
Query: 167 TGNRCQH---------QAQTDVNECELYGQEGRPRLCM--------HACVNTPGSYRCTC 209
TG +C+ Q + + +L G LC H C P + C
Sbjct: 203 TGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQPQ-PC 261
Query: 210 PGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEG 258
G+ +C+DVDEC + +C QG CINT GSF+C CP G
Sbjct: 262 RRGFIPNIRTGACQDVDECQAIPGIC-QGGNCINTVGSFEC---RCPAG 306
Score = 53.9 bits (128), Expect = 2e-07
Identities = 28/86 (32%), Positives = 38/86 (44%), Gaps = 6/86 (6%)
Query: 134 CRGISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRL 193
C +ECS+ +C + Y+C CP G + ++ A DVNEC
Sbjct: 2652 CVDENECSNPNACGSASCYNTLGSYKCACPSGFSFDQFS-SACHDVNECS-----SSKNP 2705
Query: 194 CMHACVNTPGSYRCTCPGGYRTLADG 219
C + C NT G Y C CP GY + G
Sbjct: 2706 CNYGCSNTEGGYLCGCPPGYYRVGQG 2731
Score = 52.4 bits (124), Expect = 7e-07
Identities = 35/110 (31%), Positives = 50/110 (45%), Gaps = 12/110 (10%)
Query: 137 ISECSSQP--CQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLC 194
I EC P CQ GG C+ ++C CP G + + D++EC + P +C
Sbjct: 1651 IDECQELPGLCQ-GGNCINTFGSFQCECPQGYYLSEDTRICE-DIDECFAH-----PGVC 1703
Query: 195 -MHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCIN 243
C NT G+Y C CP Y + G +C D+ + + GTTC N
Sbjct: 1704 GPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSY--NGTTCEN 1751
>gi|55770876 notch4 preproprotein [Homo sapiens]
Length = 2003
Score = 94.4 bits (233), Expect = 2e-19
Identities = 68/196 (34%), Positives = 92/196 (46%), Gaps = 40/196 (20%)
Query: 107 CNPGFRLVGPSSVVCLPNGTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPPGR 166
C PGF +GP V N C S CQNGGTC +G++ Y C+CP
Sbjct: 264 CPPGF--IGPDCEVNPDN---------------CVSHQCQNGGTCQDGLDTYTCLCPETW 306
Query: 167 TGNRCQHQAQTDVNECELYGQEGRPRLCMH--ACVNTPGSYRCTCPGGYRTLADGKSCED 224
TG C DV+ECE G P C + C N+ GS+ C C G+ G SCE+
Sbjct: 307 TGWDCSE----DVDECETQG----PPHCRNGGTCQNSAGSFHCVCVSGW----GGTSCEE 354
Query: 225 -VDECVGLQPVCPQGTTCINTGGSFQCVSPECPEGSGNVSYVKTSPFQCERNPCPMDSRP 283
+D+C+ C G+TCI+ GSF C+ P P +G + +++ C PC D++
Sbjct: 355 NLDDCIA--ATCAPGSTCIDRVGSFSCLCP--PGRTGLLCHLED---MCLSQPCHGDAQ- 406
Query: 284 CRHLPKTISFHYLSLP 299
C P T S L P
Sbjct: 407 CSTNPLTGSTLCLCQP 422
Score = 87.0 bits (214), Expect = 3e-17
Identities = 61/196 (31%), Positives = 87/196 (44%), Gaps = 53/196 (27%)
Query: 121 CLPNGTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQ------ 174
C+ W G + +C + C G TC++ V + C+CPPGRTG C +
Sbjct: 341 CVCVSGWGGTSCE-ENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLEDMCLSQ 399
Query: 175 -----------------------------AQTDVNECELYGQEGRPRLCMH--ACVNTPG 203
D++EC L Q+G P C H +C+NTPG
Sbjct: 400 PCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDEC-LMAQQG-PSPCEHGGSCLNTPG 457
Query: 204 SYRCTCPGGYRTLADGKSCE-DVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEG-SGN 261
S+ C CP GY G CE D +EC+ QP C G+TC++ +F C+ CP G G
Sbjct: 458 SFNCLCPPGY----TGSRCEADHNECLS-QP-CHPGSTCLDLLATFHCL---CPPGLEGQ 508
Query: 262 VSYVKTSPFQCERNPC 277
+ V+T+ +C PC
Sbjct: 509 LCEVETN--ECASAPC 522
Score = 81.6 bits (200), Expect = 1e-15
Identities = 61/194 (31%), Positives = 84/194 (43%), Gaps = 36/194 (18%)
Query: 121 CLPNGTWTGEQPHCRGISECSSQPCQNGGTC-VEGVNQYRCICPPGRTGNRCQHQAQTDV 179
CLP +TGE+ + C C G C ++ + +C C PG TG +CQ +
Sbjct: 105 CLPG--FTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQCQLRDFCSA 162
Query: 180 NECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCE-DVDECVGLQPVCPQG 238
N C G C+ T +C CP G+ +G +CE DV+EC CP+G
Sbjct: 163 NPCVNGG----------VCLATYPQIQCHCPPGF----EGHACERDVNECFQDPGPCPKG 208
Query: 239 TTCINTGGSFQCVSPECPEGSGNVSYVKTSPFQCE--RNPCP----MDSRPCRHLP-KTI 291
T+C NT GSFQC+ P EG +CE PCP + C+ +P K
Sbjct: 209 TSCHNTLGSFQCLCPVGQEGP-----------RCELRAGPCPPRGCSNGGTCQLMPEKDS 257
Query: 292 SFHYLSLPSNLKTP 305
+FH P P
Sbjct: 258 TFHLCLCPPGFIGP 271
Score = 79.0 bits (193), Expect = 7e-15
Identities = 63/187 (33%), Positives = 78/187 (41%), Gaps = 28/187 (14%)
Query: 94 GSKYLVDHEVHFTCNPGFRLVGPSSVVCLPNGTWTGEQPHCRG-ISECSSQPCQNGGTCV 152
GS E + TC+ G SS VC + WTG P C + C S PC +GGTC
Sbjct: 654 GSPGCAPPEDNCTCHHGH--CQRSSCVC--DVGWTG--PECEAELGGCISAPCAHGGTCY 707
Query: 153 EGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGG 212
+ Y C CP G TG C E+ P L +C +PG Y CTCP
Sbjct: 708 PQPSGYNCTCPTGYTGPTCSE---------EMTACHSGPCLNGGSCNPSPGGYYCTCPPS 758
Query: 213 YRTLADGKSCE-DVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEG-SGNVSYVKTSPF 270
+ G C+ D CV C G TC+N G+F C+ C G G K P
Sbjct: 759 H----TGPQCQTSTDYCVSAP--CFNGGTCVNRPGTFSCL---CAMGFQGPRCEGKLRP- 808
Query: 271 QCERNPC 277
C +PC
Sbjct: 809 SCADSPC 815
Score = 76.6 bits (187), Expect = 4e-14
Identities = 60/170 (35%), Positives = 77/170 (45%), Gaps = 31/170 (18%)
Query: 121 CLPNGTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVN 180
C+P WTGEQ R CS+ PC NGG C+ Q +C CPPG G+ C+ DVN
Sbjct: 145 CMPG--WTGEQCQLRDF--CSANPCVNGGVCLATYPQIQCHCPPGFEGHACER----DVN 196
Query: 181 ECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTT 240
EC Q+ P +C NT GS++C CP G +G CE + P P+G
Sbjct: 197 EC---FQDPGPCPKGTSCHNTLGSFQCLCPVG----QEGPRCE-----LRAGPCPPRG-- 242
Query: 241 CINTGGSFQCVSPECPEGSGNVSYVKTSPF----QCERNPCPMDSRPCRH 286
C N GG+ Q + PE P CE NP S C++
Sbjct: 243 CSN-GGTCQLM----PEKDSTFHLCLCPPGFIGPDCEVNPDNCVSHQCQN 287
Score = 76.3 bits (186), Expect = 5e-14
Identities = 50/144 (34%), Positives = 65/144 (45%), Gaps = 22/144 (15%)
Query: 137 ISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMH 196
++ C S+PCQNG TC+ + Y C C PG G C EL + +P
Sbjct: 931 VNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSK---------ELDACQSQPCHNHG 981
Query: 197 ACVNTPGSYRCTCPGGYRTLADGKSCE-DVDECVGLQPVCPQGT-TCINTGGSFQCVSPE 254
C PG + C CP G+ G CE DVDEC+ QP P GT C + +F C +
Sbjct: 982 TCTPKPGGFHCACPPGF----VGLRCEGDVDECLD-QPCHPTGTAACHSLANAFYC---Q 1033
Query: 255 C-PEGSGNVSYVKTSPFQCERNPC 277
C P +G V+ P C PC
Sbjct: 1034 CLPGHTGQWCEVEIDP--CHSQPC 1055
Score = 75.5 bits (184), Expect = 8e-14
Identities = 54/174 (31%), Positives = 76/174 (43%), Gaps = 22/174 (12%)
Query: 116 PSSVVCLPNGTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQA 175
P S CL +TG + +EC SQPC G TC++ + + C+CPPG G C
Sbjct: 456 PGSFNCLCPPGYTGSRCEADH-NECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLC---- 510
Query: 176 QTDVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSC-EDVDECVGLQPV 234
+ + NEC P L C + ++C C G+ G C ED+DEC
Sbjct: 511 EVETNEC-----ASAPCLNHADCHDLLNGFQCICLPGF----SGTRCEEDIDEC--RSSP 559
Query: 235 CPQGTTCINTGGSFQCVSPECPEGSGNVSYVKTSPFQCERNPCPMDSRPCRHLP 288
C G C + G+F C EG +T +C +PCP+ + C LP
Sbjct: 560 CANGGQCQDQPGAFHCKCLPGFEG----PRCQTEVDECLSDPCPVGA-SCLDLP 608
Score = 73.9 bits (180), Expect = 2e-13
Identities = 61/194 (31%), Positives = 79/194 (40%), Gaps = 28/194 (14%)
Query: 106 TCNPGFRLVGPSSVVCLPNGTWTGEQPHC-RGISECSSQPCQNGGTCVEGVNQYRCICPP 164
TC P PS C +TG P C ++ C S PC NGG+C Y C CPP
Sbjct: 705 TCYPQ-----PSGYNCTCPTGYTG--PTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPP 757
Query: 165 GRTGNRCQHQAQTDVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCED 224
TG +C QT + C P CVN PG++ C C G++ G CE
Sbjct: 758 SHTGPQC----QTSTDYC-----VSAPCFNGGTCVNRPGTFSCLCAMGFQ----GPRCEG 804
Query: 225 VDECVGLQPVCPQGTTCINTGGSFQCVSPECPEGSGNVSYVKTSPFQCERNPCPMDSRPC 284
C TC ++ +C+ CP G S +T C + PCP +S
Sbjct: 805 KLRPSCADSPCRNRATCQDSPQGPRCL---CPTGYTGGS-CQTLMDLCAQKPCPRNSHCL 860
Query: 285 RHLPKTISFHYLSL 298
+ P SFH L L
Sbjct: 861 QTGP---SFHCLCL 871
Score = 72.4 bits (176), Expect = 7e-13
Identities = 66/200 (33%), Positives = 82/200 (41%), Gaps = 37/200 (18%)
Query: 115 GPSSVVCLPNGTWTGEQPHCR-GISECS----------SQPCQNGGTCVEGVNQYRCICP 163
GPS CL WTG P C +S C S C NGG CV+ Y C CP
Sbjct: 863 GPS-FHCLCLQGWTG--PLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCP 919
Query: 164 PGRTGNRCQHQAQTDVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSC- 222
PG G+ CQ VN C E RP C+ P Y C C GY DG++C
Sbjct: 920 PGFQGSLCQDH----VNPC-----ESRPCQNGATCMAQPSGYLCQCAPGY----DGQNCS 966
Query: 223 EDVDECVGLQPVCPQGTTCINTGGSFQCVSPECPEGSGNVSYVKTSPFQCERNPC-PMDS 281
+++D C QP C TC G F C CP G + + +C PC P +
Sbjct: 967 KELDACQS-QP-CHNHGTCTPKPGGFHCA---CPPGFVGLR-CEGDVDECLDQPCHPTGT 1020
Query: 282 RPCRHLPKTISFHYLSLPSN 301
C L +F+ LP +
Sbjct: 1021 AACHSLAN--AFYCQCLPGH 1038
Score = 70.9 bits (172), Expect = 2e-12
Identities = 54/188 (28%), Positives = 84/188 (44%), Gaps = 29/188 (15%)
Query: 118 SVVCLPNGTWTGEQPHCRGISEC-----SSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQ 172
S +CL ++G H + + EC PC++GG+C+ + C+CPPG TG+RC
Sbjct: 415 STLCLCQPGYSGPTCH-QDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRC- 472
Query: 173 HQAQTDVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCE-DVDECVGL 231
+ D NEC Q P C++ ++ C CP G +G+ CE + +EC
Sbjct: 473 ---EADHNEC--LSQPCHPG---STCLDLLATFHCLCPPG----LEGQLCEVETNECASA 520
Query: 232 QPVCPQGTTCINTGGSFQCVSPECPEGSGNVSYVKTSPFQCERNPCPMDSRPCRHLPKTI 291
C C + FQC+ P SG + + +C +PC + C+ P
Sbjct: 521 P--CLNHADCHDLLNGFQCIC--LPGFSG--TRCEEDIDECRSSPC-ANGGQCQDQPG-- 571
Query: 292 SFHYLSLP 299
+FH LP
Sbjct: 572 AFHCKCLP 579
Score = 67.4 bits (163), Expect = 2e-11
Identities = 65/217 (29%), Positives = 86/217 (39%), Gaps = 46/217 (21%)
Query: 116 PSSVVCLPNGTWTGEQPHC-RGISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQ 174
PS +C + G+ +C + + C SQPC N GTC + C CPPG G RC
Sbjct: 949 PSGYLCQCAPGYDGQ--NCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRC--- 1003
Query: 175 AQTDVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCE-DVDECVGLQP 233
+ DV+EC Q P AC + ++ C C G+ G+ CE ++D C QP
Sbjct: 1004 -EGDVDEC--LDQPCHP-TGTAACHSLANAFYCQCLPGH----TGQWCEVEIDPCHS-QP 1054
Query: 234 VCPQGTTCINTGGSFQCVSPECPEGSGNVSYVKTSPFQCERNPCPMDSRPCRHLPKTISF 293
C G TC T GS CP+G + C H + F
Sbjct: 1055 -CFHGGTCEATAGSPLGFICHCPKG--------------------FEGPTCSHRAPSCGF 1093
Query: 294 HY-----LSLPSNLKTPITLFRMATASAPGRAGPNSL 325
H+ L LPS P F A G GP+ L
Sbjct: 1094 HHCHHGGLCLPS----PKPGFPPRCACLSGYGGPDCL 1126
Score = 57.4 bits (137), Expect = 2e-08
Identities = 50/181 (27%), Positives = 67/181 (37%), Gaps = 49/181 (27%)
Query: 104 HFTCNP---GFRLVGPSSVVCLPNGTWTGEQPHCRG-ISECSSQPCQNGGT--CVEGVNQ 157
H TC P GF P V L C G + EC QPC GT C N
Sbjct: 980 HGTCTPKPGGFHCACPPGFVGL----------RCEGDVDECLDQPCHPTGTAACHSLANA 1029
Query: 158 YRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMHA--CVNTPGS---YRCTCPGG 212
+ C C PG TG C+ +++ C + C H C T GS + C CP G
Sbjct: 1030 FYCQCLPGHTGQWCE----VEIDPCH-------SQPCFHGGTCEATAGSPLGFICHCPKG 1078
Query: 213 YRTLADGKSCEDVDECVGL-------------QPVCPQGTTCINTGGSFQCVSPECPEGS 259
+ +G +C G +P P C++ G C++P P+G
Sbjct: 1079 F----EGPTCSHRAPSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTPPAPKGC 1134
Query: 260 G 260
G
Sbjct: 1135 G 1135
Score = 55.5 bits (132), Expect = 8e-08
Identities = 56/230 (24%), Positives = 73/230 (31%), Gaps = 74/230 (32%)
Query: 121 CLPNGTWTGEQPHCRG-ISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQ------- 172
CLP E P C+ + EC S PC G +C++ + C+CP G TG C+
Sbjct: 577 CLPGF----EGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPN 632
Query: 173 -----------------------------------HQAQTDVNEC-------------EL 184
H + C EL
Sbjct: 633 LCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQRSSCVCDVGWTGPECEAEL 692
Query: 185 YGQEGRPRLCMH--ACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCI 242
G P C H C P Y CTCP GY G +C + P C G +C
Sbjct: 693 GGCISAP--CAHGGTCYPQPSGYNCTCPTGY----TGPTCSEEMTACHSGP-CLNGGSCN 745
Query: 243 NTGGSFQCVSPECPEGSGNVSYVKTSPFQCERNPCPMDSRPCRHLPKTIS 292
+ G + C P G +TS C PC + C + P T S
Sbjct: 746 PSPGGYYCTCPPSHTG----PQCQTSTDYCVSAPC-FNGGTCVNRPGTFS 790
Score = 52.0 bits (123), Expect = 9e-07
Identities = 47/187 (25%), Positives = 74/187 (39%), Gaps = 28/187 (14%)
Query: 116 PSSVVCLPNGTWTGEQPHCRGISE-CSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQ 174
P CL +TG C+ + + C+ +PC C++ + C+C G TG C +
Sbjct: 825 PQGPRCLCPTGYTGGS--CQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLC-NL 881
Query: 175 AQTDVNECELYGQEGRPRLCMHA--CVNTPGSYRCTCPGGYRTLADGKSCED-VDECVGL 231
+ + L LC + CV++ SY C CP G++ G C+D V+ C
Sbjct: 882 PLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQ----GSLCQDHVNPCESR 937
Query: 232 QPVCPQGTTCINTGGSFQCVSPECPEGSGNVSYVKTSPFQCERNPCPMDSRPCRH----L 287
C G TC+ + C +C G + C + S+PC +
Sbjct: 938 P--CQNGATCMAQPSGYLC---QCAPGYDGQN--------CSKELDACQSQPCHNHGTCT 984
Query: 288 PKTISFH 294
PK FH
Sbjct: 985 PKPGGFH 991
Score = 42.4 bits (98), Expect = 7e-04
Identities = 40/149 (26%), Positives = 56/149 (37%), Gaps = 30/149 (20%)
Query: 143 QPCQNGGTCVE-GVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMHACVNT 201
+PC NGGTC+ + Q C C PG G CQ +L G + + A +
Sbjct: 33 EPCANGGTCLSLSLGQGTCQCAPGFLGETCQF--PDPCQNAQLCQNGGSCQALLPAPLGL 90
Query: 202 PG-------SYRCTCPGGYRTLADGKSCEDVDECVGLQPVCP------QGTTCINTGGSF 248
P S+ CTC G+ G+ C+ L+ CP +G I G
Sbjct: 91 PSSPSPLTPSFLCTCLPGF----TGERCQ-----AKLEDPCPPSFCSKRGRCHIQASGRP 141
Query: 249 QCVSPECPEGSGNVSYVKTSPFQCERNPC 277
QC P +G ++ C NPC
Sbjct: 142 QCSC--MPGWTGEQCQLRDF---CSANPC 165
Score = 29.6 bits (65), Expect = 4.9
Identities = 14/33 (42%), Positives = 16/33 (48%), Gaps = 4/33 (12%)
Query: 144 PCQNGGTCVE----GVNQYRCICPPGRTGNRCQ 172
PC G+C E G +RC CP G RCQ
Sbjct: 1139 PCLYNGSCSETTGLGGPGFRCSCPHSSPGPRCQ 1171
>gi|148886654 polydom [Homo sapiens]
Length = 3571
Score = 93.2 bits (230), Expect = 4e-19
Identities = 63/165 (38%), Positives = 85/165 (51%), Gaps = 21/165 (12%)
Query: 113 LVGPSSVVCLPNGTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQ 172
LVG C P+G +TG++ I+ECSS PC N G CV+GV YRC C G G C
Sbjct: 1249 LVGEFICEC-PSG-YTGQRCE-ENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHC- 1304
Query: 173 HQAQTDVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQ 232
+T+VNEC + P L C + G + C CP G+ GK +VDEC+ Q
Sbjct: 1305 ---ETEVNEC-----QSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGK---NVDECLS-Q 1352
Query: 233 PVCPQGTTCINTGGSFQCVSPECPEGSGNVSYVKTSPFQCERNPC 277
P C G TC + SF+C+ C G S+ + + +C+ NPC
Sbjct: 1353 P-CKNGATCKDGANSFRCL---CAAGFTG-SHCELNINECQSNPC 1392
Score = 72.8 bits (177), Expect = 5e-13
Identities = 44/142 (30%), Positives = 68/142 (47%), Gaps = 24/142 (16%)
Query: 139 ECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMH-- 196
EC PC N GTC + Y C+CP G TG +C +TD++EC P C++
Sbjct: 1196 ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKC----ETDIDECS-------PLPCLNNG 1244
Query: 197 ACVNTPGSYRCTCPGGYRTLADGKSCED-VDECVGLQPVCPQGTTCINTGGSFQCVSPEC 255
C + G + C CP GY G+ CE+ ++EC C C++ ++C C
Sbjct: 1245 VCKDLVGEFICECPSGY----TGQRCEENINEC--SSSPCLNKGICVDGVAGYRCT---C 1295
Query: 256 PEGSGNVSYVKTSPFQCERNPC 277
+G + + +T +C+ NPC
Sbjct: 1296 VKGFVGL-HCETEVNECQSNPC 1316
Score = 72.4 bits (176), Expect = 7e-13
Identities = 34/89 (38%), Positives = 47/89 (52%), Gaps = 13/89 (14%)
Query: 135 RGISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLC 194
+ + EC SQPC+NG TC +G N +RC+C G TG+ C + ++NEC + P
Sbjct: 1344 KNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHC----ELNINEC-----QSNPCRN 1394
Query: 195 MHACVNTPGSYRCTCPGGYRTLADGKSCE 223
CV+ SY C C G+ GK CE
Sbjct: 1395 QATCVDELNSYSCKCQPGF----SGKRCE 1419
Score = 65.1 bits (157), Expect = 1e-10
Identities = 57/191 (29%), Positives = 76/191 (39%), Gaps = 40/191 (20%)
Query: 65 LQNSVGRVGPDALPVSC----------PALNTPADGRKFGSKYLVDHEVHFTCNPGFRLV 114
L VG+V D+ + C P L T ++ K GSK V+ C+PGF+LV
Sbjct: 1612 LSGIVGKVKIDSKSIFCSDCPRLGGSVPHLRTASEDLKPGSK------VNLFCDPGFQLV 1665
Query: 115 GPSSVVCLPNGTWTGEQPHCRGISECSSQPCQNG--------------GTCVEG---VNQ 157
G CL G WT PHC IS P +NG C G +
Sbjct: 1666 GNPVQYCLNQGQWTQPLPHCERISCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGD 1725
Query: 158 YRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMHACVNTPGSYRCTCPGGYRTLA 217
R C + N DV+EC + G +C+N GSY C+C Y
Sbjct: 1726 SRMFCTDNGSWNGVSPSC-LDVDECAV----GSDCSEHASCLNVDGSYICSCVPPY--TG 1778
Query: 218 DGKSCEDVDEC 228
DGK+C + +C
Sbjct: 1779 DGKNCAEPIKC 1789
Score = 61.6 bits (148), Expect = 1e-09
Identities = 28/71 (39%), Positives = 40/71 (56%), Gaps = 1/71 (1%)
Query: 74 PDALPVSCPALNTPADGRKFGSKYLVDHEVHFTCNPGFRLVGPSSVVCLPNGTWTGEQPH 133
P +PV C + A+G+ G +Y E+ +TCN GF L G S VCL NG+W+G P
Sbjct: 2826 PICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPD 2885
Query: 134 CRGISECSSQP 144
C + C++ P
Sbjct: 2886 CVPV-RCATPP 2895
Score = 60.8 bits (146), Expect = 2e-09
Identities = 29/67 (43%), Positives = 38/67 (56%), Gaps = 3/67 (4%)
Query: 115 GPSSVVCLPNGTWTGEQPHCR-GISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQH 173
G +S CL +TG HC I+EC S PC+N TCV+ +N Y C C PG +G RC+
Sbjct: 1363 GANSFRCLCAAGFTGS--HCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCET 1420
Query: 174 QAQTDVN 180
+ T N
Sbjct: 1421 EQSTGFN 1427
Score = 60.5 bits (145), Expect = 3e-09
Identities = 48/163 (29%), Positives = 62/163 (38%), Gaps = 45/163 (27%)
Query: 94 GSKYLVDHEVHFTCNPGFRLVGPSSVVCLPNGTWTGEQPHCRGISECSSQPCQNGGTCVE 153
G Y + ++C G+ L G VCL NGTWT P CR + PCQNGG C
Sbjct: 3429 GVHYQYGDMITYSCYSGYMLEGFLRSVCLENGTWT-SPPICRAVCRF---PCQNGGIC-- 3482
Query: 154 GVNQYRCICPPGRTGNRCQHQAQTDVNECELYGQEGRPRLCMHACVN---TPGSYRCTCP 210
C CP G G C+ +C+ C+N Y+C CP
Sbjct: 3483 -QRPNACSCPEGWMGRLCEEP------------------ICILPCLNGGRCVAPYQCDCP 3523
Query: 211 GGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSP 253
G+ G C VC + C+N G +CV P
Sbjct: 3524 PGW----TGSRCHTA--------VCQ--SPCLNGG---KCVRP 3549
Score = 57.8 bits (138), Expect = 2e-08
Identities = 27/78 (34%), Positives = 40/78 (51%), Gaps = 2/78 (2%)
Query: 76 ALPVSCPALNTPADGRKFGSKYLVDHEVHFTCNPGFRLVGPSSVVCLPNGTWTGEQPHCR 135
A P+ C A P +G G Y V EV F+C G++L+G + + CL +G W P+C+
Sbjct: 1784 AEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCK 1843
Query: 136 GISECSSQPCQNGGTCVE 153
+S C G C+E
Sbjct: 1844 AVS-CGKPAIPENG-CIE 1859
Score = 57.0 bits (136), Expect = 3e-08
Identities = 51/197 (25%), Positives = 72/197 (36%), Gaps = 58/197 (29%)
Query: 79 VSCPALNTPADGRKFGSKYLVDHEV--HFT------CNPGFRLVGPSSVVCLPNGTWTGE 130
V CPAL P +G Y + + HF C+PGF LVG S ++CLPNG W+G
Sbjct: 376 VHCPALKPPENG------YFIQNTCNNHFNAACGVRCHPGFDLVGSSIILCLPNGLWSGS 429
Query: 131 QPHCR------------GISECSSQPCQNGGTCVEGVNQ-YRCICPPGRTGNRCQHQAQT 177
+ +CR G CS++ TC+ ++ YR G CQ +Q
Sbjct: 430 ESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRL---EGSDKLTCQGNSQW 486
Query: 178 DVNE-------CELYGQEGRPRLCMHACVNTPGSY---------------------RCTC 209
D E C + + H C P + RCT
Sbjct: 487 DGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGFILSGVKEMLRCTT 546
Query: 210 PGGYRTLADGKSCEDVD 226
G + C+DV+
Sbjct: 547 SGKWNVGVQAAVCKDVE 563
Score = 51.6 bits (122), Expect = 1e-06
Identities = 25/54 (46%), Positives = 32/54 (59%), Gaps = 2/54 (3%)
Query: 103 VHFTCNPGFRLVGPSSVVCLPNGTWTGEQPHCRGISECSSQPCQNGGTCVEGVN 156
V ++CN GFRL GPS++ CL G W + P C I S QP +NG VEG +
Sbjct: 2520 VTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENG--FVEGAD 2571
Score = 49.7 bits (117), Expect = 5e-06
Identities = 27/82 (32%), Positives = 35/82 (42%), Gaps = 7/82 (8%)
Query: 85 NTPADGRKFGSKYLVDHEVHFTCNPGFRLVGPSSVVCLPNGTWTGEQPHCRGISECSSQP 144
NT S +L V +TCNPG+ L+G ++C +GTW G P C I EC
Sbjct: 2663 NTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISI-ECDLPT 2721
Query: 145 CQNGG------TCVEGVNQYRC 160
G T + QY C
Sbjct: 2722 APENGFLRFTETSMGSAVQYSC 2743
Score = 48.9 bits (115), Expect = 8e-06
Identities = 33/107 (30%), Positives = 47/107 (43%), Gaps = 5/107 (4%)
Query: 59 KSRLAALQNSVGRVGPDALPVSCPALNTPADGRKFGSKYLVDHEVHFTCNPGFRLVGPSS 118
+SR+ S PD +PV C A+G G Y EV F C+ G+ L G
Sbjct: 2869 RSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYILHGAPK 2928
Query: 119 VVCLPNGTWTGEQPHCR----GISECSSQPCQNGGTCVEGVN-QYRC 160
+ C +G W E P C+ G E + NG + + G + QY+C
Sbjct: 2929 LTCQSDGNWDAEIPLCKPVNCGPPEDLAHGFPNGFSFIHGGHIQYQC 2975
Score = 48.5 bits (114), Expect = 1e-05
Identities = 27/77 (35%), Positives = 37/77 (48%), Gaps = 4/77 (5%)
Query: 74 PDALPVSCPALNTPADG--RKFGSKYLVDHEVHFTCNPGFRLVGPSSVVCLPNGTWTGEQ 131
P+ +PV CP +G G YL +TC PGF LVG ++ +C NG W G +
Sbjct: 2433 PECVPVECPQPEEIPNGIIDVQGLAYL--STALYTCKPGFELVGNTTTLCGENGHWLGGK 2490
Query: 132 PHCRGISECSSQPCQNG 148
P C+ I + NG
Sbjct: 2491 PTCKAIECLKPKEILNG 2507
Score = 47.8 bits (112), Expect = 2e-05
Identities = 31/116 (26%), Positives = 45/116 (38%), Gaps = 8/116 (6%)
Query: 74 PDALPVSCPALNTPADGRKFGSKYLVDHEVHFTCNPGFRLVGPSSVVCLPNGTWTGEQPH 133
P + + C P +G ++ + V ++C PG L G +CL N W+G P
Sbjct: 2710 PSCISIECDLPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPR 2769
Query: 134 CRGISECSSQPCQNG---GTCVEGVNQYRCICPPGRTGN-----RCQHQAQTDVNE 181
C IS P NG G+ ++ C PG N CQ D +E
Sbjct: 2770 CEAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDE 2825
Score = 47.4 bits (111), Expect = 2e-05
Identities = 22/61 (36%), Positives = 31/61 (50%)
Query: 74 PDALPVSCPALNTPADGRKFGSKYLVDHEVHFTCNPGFRLVGPSSVVCLPNGTWTGEQPH 133
P PV+C A G G ++ + + C PG++L G SS CL NG+W+G P
Sbjct: 2942 PLCKPVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPS 3001
Query: 134 C 134
C
Sbjct: 3002 C 3002
Score = 47.4 bits (111), Expect = 2e-05
Identities = 23/69 (33%), Positives = 32/69 (46%), Gaps = 6/69 (8%)
Query: 78 PVSCPALNTPADGRKFGSKYLVDHEVHFTCNPGFRLVGPSSVVCLPNGTWTGEQPHCRGI 137
PVSC +P G GSKY + + + C PG+ L G VC N W+G G+
Sbjct: 3238 PVSCGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQWSG------GV 3291
Query: 138 SECSSQPCQ 146
+ C C+
Sbjct: 3292 AICKETRCE 3300
Score = 43.9 bits (102), Expect = 3e-04
Identities = 39/143 (27%), Positives = 60/143 (41%), Gaps = 14/143 (9%)
Query: 18 CPEPRASQNCLSKQQLLSAIRQLQQLLKGQETRFAEGIRHMKSRLAALQNSVGRVGPDAL 77
CPEP +N L ++L + + + K EG H+ + L+ + D+
Sbjct: 2323 CPEPPLLENQLVLKELTTEVGVVTFSCK-------EG--HVLQGPSVLKCLPSQQWNDSF 2373
Query: 78 PVSCPALNTPADGRKFG-----SKYLVDHEVHFTCNPGFRLVGPSSVVCLPNGTWTGEQP 132
PV L TP FG S V ++C GF L G S+ +C P+GTW+ P
Sbjct: 2374 PVCKIVLCTPPPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLP 2433
Query: 133 HCRGISECSSQPCQNGGTCVEGV 155
C + + NG V+G+
Sbjct: 2434 ECVPVECPQPEEIPNGIIDVQGL 2456
Score = 43.5 bits (101), Expect = 3e-04
Identities = 51/206 (24%), Positives = 72/206 (34%), Gaps = 51/206 (24%)
Query: 74 PDALPVSCPA-LNTPADGRKFGSKYLVDHEVHFTCNPGFRLVGPSSVVCLPNGTWTGEQP 132
P P CP P + ++ VD V C GF L G + C P+ TWT
Sbjct: 3350 PLCKPNPCPVPFVIPENALLSEKEFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSA 3409
Query: 133 HCRGISECSSQPCQNGGTCVEGVN-QYRCICPPGRTGNRCQHQAQTDV-------NECEL 184
C IS P GV+ QY G+ + + + C
Sbjct: 3410 KCEKIS--CGPPAHVENAIARGVHYQY---------GDMITYSCYSGYMLEGFLRSVCLE 3458
Query: 185 YGQEGRPRLCMHAC---------VNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVC 235
G P +C C P + C+CP G+ G+ CE +P+C
Sbjct: 3459 NGTWTSPPICRAVCRFPCQNGGICQRPNA--CSCPEGWM----GRLCE--------EPIC 3504
Query: 236 PQGTTCINTGGSFQCVSP---ECPEG 258
C+N G +CV+P +CP G
Sbjct: 3505 I--LPCLNGG---RCVAPYQCDCPPG 3525
Score = 42.7 bits (99), Expect = 6e-04
Identities = 27/91 (29%), Positives = 38/91 (41%), Gaps = 8/91 (8%)
Query: 77 LPVSCPALNTPADGRKFGSKYLVDHEVHFTCNPGFRLVGPSSVVCLPNGTWTGEQPHCRG 136
+PV C + +G GS Y V ++CN GF + G C G W+ P C
Sbjct: 2142 IPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHP 2201
Query: 137 ISECSSQP-CQNG------GTCVEGVNQYRC 160
+S C P +NG G E +Y+C
Sbjct: 2202 VS-CGEPPKVENGFLEHTTGRIFESEVRYQC 2231
Score = 42.0 bits (97), Expect = 0.001
Identities = 22/76 (28%), Positives = 34/76 (44%), Gaps = 1/76 (1%)
Query: 74 PDALPVSCPALNTPADGRKFGSKYLVDHEVHFTCNPGFRLVGPSSVVCLPNGTWTGEQPH 133
P +SC N +G GS Y +++ C+PG+ L G C + W ++P
Sbjct: 2768 PRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPI 2827
Query: 134 CRGISECSSQPCQNGG 149
C + +CSS P G
Sbjct: 2828 CIPV-DCSSPPVSANG 2842
Score = 40.4 bits (93), Expect = 0.003
Identities = 22/82 (26%), Positives = 33/82 (40%)
Query: 74 PDALPVSCPALNTPADGRKFGSKYLVDHEVHFTCNPGFRLVGPSSVVCLPNGTWTGEQPH 133
P VSC P +G + +V + CN G+ L G CL N +W+ P
Sbjct: 1840 PYCKAVSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPV 1899
Query: 134 CRGISECSSQPCQNGGTCVEGV 155
C + S + NG + G+
Sbjct: 1900 CEPVKCSSPENINNGKYILSGL 1921
Score = 40.0 bits (92), Expect = 0.004
Identities = 27/87 (31%), Positives = 35/87 (40%), Gaps = 6/87 (6%)
Query: 60 SRLAALQNSVGRVGPDALPVSCPALNTPAD--GRKFGSKYLVDHEVHFTCNPGFRLVGPS 117
SR S P LP C +TP G G+ + C GF+L+G S
Sbjct: 2986 SRRCLSNGSWSGSSPSCLPCRC---STPVIEYGTVNGTDFDCGKAARIQCFKGFKLLGLS 3042
Query: 118 SVVCLPNGTWTGEQPHCRGISECSSQP 144
+ C +G W+ PHC S C S P
Sbjct: 3043 EITCEADGQWSSGFPHCEHTS-CGSLP 3068
Score = 39.7 bits (91), Expect = 0.005
Identities = 25/77 (32%), Positives = 34/77 (44%), Gaps = 2/77 (2%)
Query: 74 PDALPVSCPALNTPADG-RKFGSKYLVDHEVHFTCNPGFRLVGPSSVVCLPNGTWTGEQP 132
P PVSC +G + + + + EV + CNPG++ VG VC N W E P
Sbjct: 2197 PTCHPVSCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESP 2256
Query: 133 -HCRGISECSSQPCQNG 148
C + P QNG
Sbjct: 2257 LMCVPLDCGKPPPIQNG 2273
Score = 38.9 bits (89), Expect = 0.008
Identities = 22/69 (31%), Positives = 32/69 (46%), Gaps = 2/69 (2%)
Query: 77 LPVSCPALNTPADGRKFGSKYLVDHEVHFTCNPGFRLVGPSSVVCLPNGTWTGE-QPHCR 135
+P+ C +G G + V +V F CN G+ LVG SS C +G W + P C
Sbjct: 2260 VPLDCGKPPPIQNGFMKGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCM 2319
Query: 136 GISECSSQP 144
++C P
Sbjct: 2320 P-AKCPEPP 2327
Score = 38.5 bits (88), Expect = 0.011
Identities = 15/33 (45%), Positives = 20/33 (60%)
Query: 103 VHFTCNPGFRLVGPSSVVCLPNGTWTGEQPHCR 135
V ++CN G+ L GPS C NGTW+ P C+
Sbjct: 3321 VVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCK 3353
Score = 37.4 bits (85), Expect = 0.024
Identities = 15/51 (29%), Positives = 25/51 (49%), Gaps = 1/51 (1%)
Query: 94 GSKYLVDHEVHFTCNPGFRLVGPSSVVCLPNGTWTGEQPHCRGISECSSQP 144
G+ + + V +TC G+ L G ++ CL +G W+ C +S C P
Sbjct: 1976 GNNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVS-CDEPP 2025
Score = 36.2 bits (82), Expect = 0.053
Identities = 32/131 (24%), Positives = 54/131 (41%), Gaps = 6/131 (4%)
Query: 27 CLSKQQLLSAIRQLQQLLKGQETRFA--EGIR-HMKSRLAALQNSVGRV-GPDALPVSCP 82
CL +++L+ L GQ ++ G R S L L+ V P + C
Sbjct: 2498 CLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCD 2557
Query: 83 ALNTPADGRKFGSKYLVDHEVHFTCNPGFRLVGPSSVVCLPNGTWTGEQPHCRGISECSS 142
+ +G G+ Y + ++C PGF++ G + C +G W+ P C I +C
Sbjct: 2558 SPQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTCEESG-WSSSIPTCMPI-DCGL 2615
Query: 143 QPCQNGGTCVE 153
P + G C +
Sbjct: 2616 PPHIDFGDCTK 2626
Score = 35.4 bits (80), Expect = 0.090
Identities = 17/61 (27%), Positives = 26/61 (42%)
Query: 74 PDALPVSCPALNTPADGRKFGSKYLVDHEVHFTCNPGFRLVGPSSVVCLPNGTWTGEQPH 133
P PV C + +G+ S ++C+ G+ L GPS + C +G W P
Sbjct: 1898 PVCEPVKCSSPENINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPA 1957
Query: 134 C 134
C
Sbjct: 1958 C 1958
Score = 34.7 bits (78), Expect = 0.15
Identities = 13/45 (28%), Positives = 24/45 (53%), Gaps = 1/45 (2%)
Query: 100 DHEVHFTCNPGFRLVGPSSVVCLPNGTWTGEQPHCRGISECSSQP 144
++ + ++C G+ + G S ++C G W+ P C +S C S P
Sbjct: 3083 ENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLS-CGSPP 3126
Score = 29.6 bits (65), Expect = 4.9
Identities = 17/61 (27%), Positives = 26/61 (42%), Gaps = 3/61 (4%)
Query: 70 GRVGPDAL---PVSCPALNTPADGRKFGSKYLVDHEVHFTCNPGFRLVGPSSVVCLPNGT 126
GR P+ + P CP G + V+ +V +C G+ G + VC +GT
Sbjct: 3167 GRWFPERISCSPKKCPLPENITHILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGT 3226
Query: 127 W 127
W
Sbjct: 3227 W 3227
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.439
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,901,699
Number of Sequences: 37866
Number of extensions: 1050969
Number of successful extensions: 6133
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 244
Number of HSP's successfully gapped in prelim test: 203
Number of HSP's that attempted gapping in prelim test: 2547
Number of HSP's gapped (non-prelim): 2019
length of query: 393
length of database: 18,247,518
effective HSP length: 104
effective length of query: 289
effective length of database: 14,309,454
effective search space: 4135432206
effective search space used: 4135432206
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.