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Search of human proteins with 187607300
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|187607300 versican isoform 2 [Homo sapiens]
(655 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|187607300 versican isoform 2 [Homo sapiens] 1410 0.0
gi|21361116 versican isoform 1 [Homo sapiens] 721 0.0
gi|118600983 chondroitin sulfate proteoglycan 3 [Homo sapiens] 379 e-105
gi|126090892 aggrecan isoform 2 precursor [Homo sapiens] 361 1e-99
gi|126090883 aggrecan isoform 1 precursor [Homo sapiens] 361 1e-99
gi|38372931 brevican isoform 2 [Homo sapiens] 322 5e-88
gi|38372935 brevican isoform 1 [Homo sapiens] 322 5e-88
gi|4503053 hyaluronan and proteoglycan link protein 1 [Homo sapi... 217 2e-56
gi|30102948 hyaluronan and proteoglycan link protein 3 [Homo sap... 217 3e-56
gi|11141887 brain link protein-1 [Homo sapiens] 194 2e-49
gi|30794472 hyaluronan and proteoglycan link protein 4 [Homo sap... 194 3e-49
gi|110624774 mannose receptor, C type 2 [Homo sapiens] 109 9e-24
gi|24041035 notch 2 preproprotein [Homo sapiens] 108 1e-23
gi|21704279 jagged 2 isoform b precursor [Homo sapiens] 100 7e-21
gi|21704277 jagged 2 isoform a precursor [Homo sapiens] 99 9e-21
gi|134244285 Notch homolog 3 [Homo sapiens] 99 2e-20
gi|148833508 notch1 preproprotein [Homo sapiens] 98 3e-20
gi|148886654 polydom [Homo sapiens] 97 6e-20
gi|4759146 slit homolog 2 [Homo sapiens] 93 7e-19
gi|9506545 delta-like 4 protein precursor [Homo sapiens] 93 9e-19
gi|55770876 notch4 preproprotein [Homo sapiens] 93 9e-19
gi|4557679 jagged 1 precursor [Homo sapiens] 92 2e-18
gi|33667103 C-type lectin, superfamily member 14 isoform 1 [Homo... 92 2e-18
gi|53832016 C-type lectin, superfamily member 14 isoform 2 [Homo... 92 2e-18
gi|110735443 delta-like 1 [Homo sapiens] 92 2e-18
gi|112420992 crumbs homolog 2 [Homo sapiens] 92 2e-18
gi|18641360 collectin sub-family member 12 [Homo sapiens] 91 3e-18
gi|122937283 6720455I24Rik homolog [Homo sapiens] 91 3e-18
gi|11321571 slit homolog 3 [Homo sapiens] 90 6e-18
gi|8393264 delta-like 3 protein isoform 1 precursor [Homo sapiens] 89 1e-17
>gi|187607300 versican isoform 2 [Homo sapiens]
Length = 655
Score = 1410 bits (3650), Expect = 0.0
Identities = 655/655 (100%), Positives = 655/655 (100%)
Query: 1 MFINIKSILWMCSTLIVTHALHKVKVGKSPPVRGSLSGKVSLPCHFSTMPTLPPSYNTSE 60
MFINIKSILWMCSTLIVTHALHKVKVGKSPPVRGSLSGKVSLPCHFSTMPTLPPSYNTSE
Sbjct: 1 MFINIKSILWMCSTLIVTHALHKVKVGKSPPVRGSLSGKVSLPCHFSTMPTLPPSYNTSE 60
Query: 61 FLRIKWSKIEVDKNGKDLKETTVLVAQNGNIKIGQDYKGRVSVPTHPEAVGDASLTVVKL 120
FLRIKWSKIEVDKNGKDLKETTVLVAQNGNIKIGQDYKGRVSVPTHPEAVGDASLTVVKL
Sbjct: 61 FLRIKWSKIEVDKNGKDLKETTVLVAQNGNIKIGQDYKGRVSVPTHPEAVGDASLTVVKL 120
Query: 121 LASDAGLYRCDVMYGIEDTQDTVSLTVDGVVFHYRAATSRYTLNFEAAQKACLDVGAVIA 180
LASDAGLYRCDVMYGIEDTQDTVSLTVDGVVFHYRAATSRYTLNFEAAQKACLDVGAVIA
Sbjct: 121 LASDAGLYRCDVMYGIEDTQDTVSLTVDGVVFHYRAATSRYTLNFEAAQKACLDVGAVIA 180
Query: 181 TPEQLFAAYEDGFEQCDAGWLADQTVRYPIRAPRVGCYGDKMGKAGVRTYGFRSPQETYD 240
TPEQLFAAYEDGFEQCDAGWLADQTVRYPIRAPRVGCYGDKMGKAGVRTYGFRSPQETYD
Sbjct: 181 TPEQLFAAYEDGFEQCDAGWLADQTVRYPIRAPRVGCYGDKMGKAGVRTYGFRSPQETYD 240
Query: 241 VYCYVDHLDGDVFHLTVPSKFTFEEAAKECENQDARLATVGELQAAWRNGFDQCDYGWLS 300
VYCYVDHLDGDVFHLTVPSKFTFEEAAKECENQDARLATVGELQAAWRNGFDQCDYGWLS
Sbjct: 241 VYCYVDHLDGDVFHLTVPSKFTFEEAAKECENQDARLATVGELQAAWRNGFDQCDYGWLS 300
Query: 301 DASVRHPVTVARAQCGGGLLGVRTLYRFENQTGFPPPDSRFDAYCFKRPDRCKMNPCLNG 360
DASVRHPVTVARAQCGGGLLGVRTLYRFENQTGFPPPDSRFDAYCFKRPDRCKMNPCLNG
Sbjct: 301 DASVRHPVTVARAQCGGGLLGVRTLYRFENQTGFPPPDSRFDAYCFKRPDRCKMNPCLNG 360
Query: 361 GTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFRCLCLPSYVGAL 420
GTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFRCLCLPSYVGAL
Sbjct: 361 GTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFRCLCLPSYVGAL 420
Query: 421 CEQDTETCDYGWHKFQGQCYKYFAHRRTWDAAERECRLQGAHLTSILSHEEQMFVNRVGH 480
CEQDTETCDYGWHKFQGQCYKYFAHRRTWDAAERECRLQGAHLTSILSHEEQMFVNRVGH
Sbjct: 421 CEQDTETCDYGWHKFQGQCYKYFAHRRTWDAAERECRLQGAHLTSILSHEEQMFVNRVGH 480
Query: 481 DYQWIGLNDKMFEHDFRWTDGSTLQYENWRPNQPDSFFSAGEDCVVIIWHENGQWNDVPC 540
DYQWIGLNDKMFEHDFRWTDGSTLQYENWRPNQPDSFFSAGEDCVVIIWHENGQWNDVPC
Sbjct: 481 DYQWIGLNDKMFEHDFRWTDGSTLQYENWRPNQPDSFFSAGEDCVVIIWHENGQWNDVPC 540
Query: 541 NYHLTYTCKKGTVACGQPPVVENAKTFGKMKPRYEINSLIRYHCKDGFIQRHLPTIRCLG 600
NYHLTYTCKKGTVACGQPPVVENAKTFGKMKPRYEINSLIRYHCKDGFIQRHLPTIRCLG
Sbjct: 541 NYHLTYTCKKGTVACGQPPVVENAKTFGKMKPRYEINSLIRYHCKDGFIQRHLPTIRCLG 600
Query: 601 NGRWAIPKITCMNPSAYQRTYSMKYFKNSSSAKDNSINTSKHDHRWSRRWQESRR 655
NGRWAIPKITCMNPSAYQRTYSMKYFKNSSSAKDNSINTSKHDHRWSRRWQESRR
Sbjct: 601 NGRWAIPKITCMNPSAYQRTYSMKYFKNSSSAKDNSINTSKHDHRWSRRWQESRR 655
>gi|21361116 versican isoform 1 [Homo sapiens]
Length = 3396
Score = 721 bits (1860), Expect = 0.0
Identities = 349/366 (95%), Positives = 354/366 (96%)
Query: 1 MFINIKSILWMCSTLIVTHALHKVKVGKSPPVRGSLSGKVSLPCHFSTMPTLPPSYNTSE 60
MFINIKSILWMCSTLIVTHALHKVKVGKSPPVRGSLSGKVSLPCHFSTMPTLPPSYNTSE
Sbjct: 1 MFINIKSILWMCSTLIVTHALHKVKVGKSPPVRGSLSGKVSLPCHFSTMPTLPPSYNTSE 60
Query: 61 FLRIKWSKIEVDKNGKDLKETTVLVAQNGNIKIGQDYKGRVSVPTHPEAVGDASLTVVKL 120
FLRIKWSKIEVDKNGKDLKETTVLVAQNGNIKIGQDYKGRVSVPTHPEAVGDASLTVVKL
Sbjct: 61 FLRIKWSKIEVDKNGKDLKETTVLVAQNGNIKIGQDYKGRVSVPTHPEAVGDASLTVVKL 120
Query: 121 LASDAGLYRCDVMYGIEDTQDTVSLTVDGVVFHYRAATSRYTLNFEAAQKACLDVGAVIA 180
LASDAGLYRCDVMYGIEDTQDTVSLTVDGVVFHYRAATSRYTLNFEAAQKACLDVGAVIA
Sbjct: 121 LASDAGLYRCDVMYGIEDTQDTVSLTVDGVVFHYRAATSRYTLNFEAAQKACLDVGAVIA 180
Query: 181 TPEQLFAAYEDGFEQCDAGWLADQTVRYPIRAPRVGCYGDKMGKAGVRTYGFRSPQETYD 240
TPEQLFAAYEDGFEQCDAGWLADQTVRYPIRAPRVGCYGDKMGKAGVRTYGFRSPQETYD
Sbjct: 181 TPEQLFAAYEDGFEQCDAGWLADQTVRYPIRAPRVGCYGDKMGKAGVRTYGFRSPQETYD 240
Query: 241 VYCYVDHLDGDVFHLTVPSKFTFEEAAKECENQDARLATVGELQAAWRNGFDQCDYGWLS 300
VYCYVDHLDGDVFHLTVPSKFTFEEAAKECENQDARLATVGELQAAWRNGFDQCDYGWLS
Sbjct: 241 VYCYVDHLDGDVFHLTVPSKFTFEEAAKECENQDARLATVGELQAAWRNGFDQCDYGWLS 300
Query: 301 DASVRHPVTVARAQCGGGLLGVRTLYRFENQTGFPPPDSRFDAYCFKRPDRCKMNPCLNG 360
DASVRHPVTVARAQCGGGLLGVRTLYRFENQTGFPPPDSRFDAYCFK + ++ +
Sbjct: 301 DASVRHPVTVARAQCGGGLLGVRTLYRFENQTGFPPPDSRFDAYCFKPKEATTIDLSILA 360
Query: 361 GTCYPT 366
T P+
Sbjct: 361 ETASPS 366
Score = 692 bits (1787), Expect = 0.0
Identities = 307/307 (100%), Positives = 307/307 (100%)
Query: 349 PDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTF 408
PDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTF
Sbjct: 3090 PDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTF 3149
Query: 409 RCLCLPSYVGALCEQDTETCDYGWHKFQGQCYKYFAHRRTWDAAERECRLQGAHLTSILS 468
RCLCLPSYVGALCEQDTETCDYGWHKFQGQCYKYFAHRRTWDAAERECRLQGAHLTSILS
Sbjct: 3150 RCLCLPSYVGALCEQDTETCDYGWHKFQGQCYKYFAHRRTWDAAERECRLQGAHLTSILS 3209
Query: 469 HEEQMFVNRVGHDYQWIGLNDKMFEHDFRWTDGSTLQYENWRPNQPDSFFSAGEDCVVII 528
HEEQMFVNRVGHDYQWIGLNDKMFEHDFRWTDGSTLQYENWRPNQPDSFFSAGEDCVVII
Sbjct: 3210 HEEQMFVNRVGHDYQWIGLNDKMFEHDFRWTDGSTLQYENWRPNQPDSFFSAGEDCVVII 3269
Query: 529 WHENGQWNDVPCNYHLTYTCKKGTVACGQPPVVENAKTFGKMKPRYEINSLIRYHCKDGF 588
WHENGQWNDVPCNYHLTYTCKKGTVACGQPPVVENAKTFGKMKPRYEINSLIRYHCKDGF
Sbjct: 3270 WHENGQWNDVPCNYHLTYTCKKGTVACGQPPVVENAKTFGKMKPRYEINSLIRYHCKDGF 3329
Query: 589 IQRHLPTIRCLGNGRWAIPKITCMNPSAYQRTYSMKYFKNSSSAKDNSINTSKHDHRWSR 648
IQRHLPTIRCLGNGRWAIPKITCMNPSAYQRTYSMKYFKNSSSAKDNSINTSKHDHRWSR
Sbjct: 3330 IQRHLPTIRCLGNGRWAIPKITCMNPSAYQRTYSMKYFKNSSSAKDNSINTSKHDHRWSR 3389
Query: 649 RWQESRR 655
RWQESRR
Sbjct: 3390 RWQESRR 3396
>gi|118600983 chondroitin sulfate proteoglycan 3 [Homo sapiens]
Length = 1321
Score = 379 bits (973), Expect = e-105
Identities = 155/270 (57%), Positives = 196/270 (72%)
Query: 350 DRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFR 409
D C+ NPCL+GGTC T Y C+C G++G+ CE+D D+C +PC NG TC+D N F
Sbjct: 1010 DPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFV 1069
Query: 410 CLCLPSYVGALCEQDTETCDYGWHKFQGQCYKYFAHRRTWDAAERECRLQGAHLTSILSH 469
CLCLPSY G+ CE+DTE CD GWHKFQG CY+YFAHRR W+ AE++CR + HLTS+ S
Sbjct: 1070 CLCLPSYGGSFCEKDTEGCDRGWHKFQGHCYRYFAHRRAWEDAEKDCRRRSGHLTSVHSP 1129
Query: 470 EEQMFVNRVGHDYQWIGLNDKMFEHDFRWTDGSTLQYENWRPNQPDSFFSAGEDCVVIIW 529
EE F+N GH+ WIGLND++ E DF+WTD + LQ+ENWR NQPD+FF+ GEDCVV++
Sbjct: 1130 EEHSFINSFGHENTWIGLNDRIVERDFQWTDNTGLQFENWRENQPDNFFAGGEDCVVMVA 1189
Query: 530 HENGQWNDVPCNYHLTYTCKKGTVACGQPPVVENAKTFGKMKPRYEINSLIRYHCKDGFI 589
HE+G+WNDVPCNY+L Y CKKGTV CG PP VENA G K +Y +++ +RY C +GF
Sbjct: 1190 HESGRWNDVPCNYNLPYVCKKGTVLCGPPPAVENASLIGARKAKYNVHATVRYQCNEGFA 1249
Query: 590 QRHLPTIRCLGNGRWAIPKITCMNPSAYQR 619
Q H+ TIRC NG+W P+I C P R
Sbjct: 1250 QHHVATIRCRSNGKWDRPQIVCTKPRRSHR 1279
Score = 327 bits (837), Expect = 3e-89
Identities = 161/327 (49%), Positives = 216/327 (66%), Gaps = 6/327 (1%)
Query: 21 LHKVKVGKSPPVRGSLSGKVSLPCHFSTMPTLPPSYNTSEFLRIKWSKIEVDKNGKDLKE 80
LH K+G S V+ +L+ V+LPC F+ P + + RIKW+K+ + ++
Sbjct: 37 LHMQKLG-SGSVQAALAELVALPCLFTLQPRPSAARDAP---RIKWTKVRTASGQR--QD 90
Query: 81 TTVLVAQNGNIKIGQDYKGRVSVPTHPEAVGDASLTVVKLLASDAGLYRCDVMYGIEDTQ 140
+LVA++ +++ + ++GRVS+P++P +A+L + L ASD+GLYRC V+ GIED Q
Sbjct: 91 LPILVAKDNVVRVAKSWQGRVSLPSYPRRRANATLLLGPLRASDSGLYRCQVVRGIEDEQ 150
Query: 141 DTVSLTVDGVVFHYRAATSRYTLNFEAAQKACLDVGAVIATPEQLFAAYEDGFEQCDAGW 200
D V L V GVVFHYR+A RY L F AQ+AC A+IA P L AA+EDGF+ CDAGW
Sbjct: 151 DLVPLEVTGVVFHYRSARDRYALTFAEAQEACRLSSAIIAAPRHLQAAFEDGFDNCDAGW 210
Query: 201 LADQTVRYPIRAPRVGCYGDKMGKAGVRTYGFRSPQETYDVYCYVDHLDGDVFHLTVPSK 260
L+D+TVRYPI R GCYGD+ GVR+YG R+PQE YDVYC+ L G+VF++ +
Sbjct: 211 LSDRTVRYPITQSRPGCYGDRSSLPGVRSYGRRNPQELYDVYCFARELGGEVFYVGPARR 270
Query: 261 FTFEEAAKECENQDARLATVGELQAAWRNGFDQCDYGWLSDASVRHPVTVARAQCGGGLL 320
T A +C Q A LA+VG+L AW G DQCD GWL+D SVR+P+ R +CGG
Sbjct: 271 LTLAGARAQCRRQGAALASVGQLHLAWHEGLDQCDPGWLADGSVRYPIQTPRRRCGGPAP 330
Query: 321 GVRTLYRFENQTGFPPPDSRFDAYCFK 347
GVRT+YRF N+TGFP P RFDAYCF+
Sbjct: 331 GVRTVYRFANRTGFPSPAERFDAYCFR 357
Score = 74.7 bits (182), Expect = 2e-13
Identities = 38/89 (42%), Positives = 49/89 (55%), Gaps = 4/89 (4%)
Query: 163 LNFEAAQKACLDVGAVIATPEQLFAAYEDGFEQCDAGWLADQTVRYPIRAPRVGCYGDKM 222
L A+ C GA +A+ QL A+ +G +QCD GWLAD +VRYPI+ PR C G
Sbjct: 271 LTLAGARAQCRRQGAALASVGQLHLAWHEGLDQCDPGWLADGSVRYPIQTPRRRCGGPAP 330
Query: 223 GKAGVRTY----GFRSPQETYDVYCYVDH 247
G V + GF SP E +D YC+ H
Sbjct: 331 GVRTVYRFANRTGFPSPAERFDAYCFRAH 359
>gi|126090892 aggrecan isoform 2 precursor [Homo sapiens]
Length = 2416
Score = 361 bits (926), Expect = 1e-99
Identities = 177/357 (49%), Positives = 240/357 (67%), Gaps = 19/357 (5%)
Query: 7 SILWMCSTL-IVTHALH----------KVKVGKSPPVRGSLSGKVSLPCHF-STMPTLPP 54
++LW+ TL ++T A+ V + + P+R L +++PC+F M +
Sbjct: 3 TLLWVFVTLRVITAAVTVETSDHDNSLSVSIPQPSPLRVLLGTSLTIPCYFIDPMHPVTT 62
Query: 55 SYNTSEFL-RIKWSKIEVDKNGKDLKETTVLVAQNGNIKIGQDYKGRVSVPTHPEAVGDA 113
+ +T+ RIKWS++ +K E +LVA G +++ Y+ +VS+P +P DA
Sbjct: 63 APSTAPLAPRIKWSRVSKEK------EVVLLVATEGRVRVNSAYQDKVSLPNYPAIPSDA 116
Query: 114 SLTVVKLLASDAGLYRCDVMYGIEDTQDTVSLTVDGVVFHYRAATSRYTLNFEAAQKACL 173
+L V L ++D+G+YRC+VM+GIED++ T+ + V G+VFHYRA ++RYTL+F+ AQ+ACL
Sbjct: 117 TLEVQSLRSNDSGVYRCEVMHGIEDSEATLEVVVKGIVFHYRAISTRYTLDFDRAQRACL 176
Query: 174 DVGAVIATPEQLFAAYEDGFEQCDAGWLADQTVRYPIRAPRVGCYGDKMGKAGVRTYGFR 233
A+IATPEQL AAYEDGF QCDAGWLADQTVRYPI PR GCYGDK GVRTYG R
Sbjct: 177 QNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIR 236
Query: 234 SPQETYDVYCYVDHLDGDVFHLTVPSKFTFEEAAKECENQDARLATVGELQAAWRNGFDQ 293
ETYDVYC+ + ++G+VF+ T P KFTF+EAA EC ARLAT G+L AW+ G D
Sbjct: 237 DTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQAGMDM 296
Query: 294 CDYGWLSDASVRHPVTVARAQCGGGLLGVRTLYRFENQTGFPPPDSRFDAYCFKRPD 350
C GWL+D SVR+P++ AR CGG LLGVRT+Y NQTG+P P SR+DA C+ D
Sbjct: 297 CSAGWLADRSVRYPISKARPNCGGNLLGVRTVYVHANQTGYPDPSSRYDAICYTGED 353
Score = 332 bits (851), Expect = 7e-91
Identities = 142/230 (61%), Positives = 174/230 (75%), Gaps = 1/230 (0%)
Query: 390 CHSNPCRNGATCVDGFNTFRCLCLPSYVGALCEQDTETCDYGWHKFQGQCYKYFAHRRTW 449
C PC G TC + CLC P Y G C D E C+ GW+K+QG CY++F R TW
Sbjct: 2169 CAEEPCGAG-TCKETEGHVICLCPPGYTGEHCNIDQEVCEEGWNKYQGHCYRHFPDRETW 2227
Query: 450 DAAERECRLQGAHLTSILSHEEQMFVNRVGHDYQWIGLNDKMFEHDFRWTDGSTLQYENW 509
AER CR Q +HL+SI++ EEQ FVN DYQWIGLND+ E DFRW+DG +Q+ENW
Sbjct: 2228 VDAERRCREQQSHLSSIVTPEEQEFVNNNAQDYQWIGLNDRTIEGDFRWSDGHPMQFENW 2287
Query: 510 RPNQPDSFFSAGEDCVVIIWHENGQWNDVPCNYHLTYTCKKGTVACGQPPVVENAKTFGK 569
RPNQPD+FF+AGEDCVV+IWHE G+WNDVPCNYHL +TCKKGTVACG+PPVVE+A+TFG+
Sbjct: 2288 RPNQPDNFFAAGEDCVVMIWHEKGEWNDVPCNYHLPFTCKKGTVACGEPPVVEHARTFGQ 2347
Query: 570 MKPRYEINSLIRYHCKDGFIQRHLPTIRCLGNGRWAIPKITCMNPSAYQR 619
K RYEINSL+RY C +GF+QRH+PTIRC +G W P+ITC +P+ Y+R
Sbjct: 2348 KKDRYEINSLVRYQCTEGFVQRHMPTIRCQPSGHWEEPQITCTDPTTYKR 2397
Score = 255 bits (652), Expect = 8e-68
Identities = 120/199 (60%), Positives = 144/199 (72%)
Query: 149 GVVFHYRAATSRYTLNFEAAQKACLDVGAVIATPEQLFAAYEDGFEQCDAGWLADQTVRY 208
GVVFHYR +RY+L FE AQ+ACL GAVIA+PEQL AAYE G+EQCDAGWL DQTVRY
Sbjct: 477 GVVFHYRPGPTRYSLTFEEAQQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLRDQTVRY 536
Query: 209 PIRAPRVGCYGDKMGKAGVRTYGFRSPQETYDVYCYVDHLDGDVFHLTVPSKFTFEEAAK 268
PI +PR C GDK GVRTYG R ETYDVYC+VD L+G+VF T +FTF+EA +
Sbjct: 537 PIVSPRTPCVGDKDSSPGVRTYGVRPSTETYDVYCFVDRLEGEVFFATRLEQFTFQEALE 596
Query: 269 ECENQDARLATVGELQAAWRNGFDQCDYGWLSDASVRHPVTVARAQCGGGLLGVRTLYRF 328
CE+ +A LAT G+L AAW G D+C GWL+D S+R+P+ R CGG GVRT+Y +
Sbjct: 597 FCESHNATLATTGQLYAAWSRGLDKCYAGWLADGSLRYPIVTPRPACGGDKPGVRTVYLY 656
Query: 329 ENQTGFPPPDSRFDAYCFK 347
NQTG P P SR A+CF+
Sbjct: 657 PNQTGLPDPLSRHHAFCFR 675
>gi|126090883 aggrecan isoform 1 precursor [Homo sapiens]
Length = 2317
Score = 361 bits (926), Expect = 1e-99
Identities = 177/357 (49%), Positives = 240/357 (67%), Gaps = 19/357 (5%)
Query: 7 SILWMCSTL-IVTHALH----------KVKVGKSPPVRGSLSGKVSLPCHF-STMPTLPP 54
++LW+ TL ++T A+ V + + P+R L +++PC+F M +
Sbjct: 3 TLLWVFVTLRVITAAVTVETSDHDNSLSVSIPQPSPLRVLLGTSLTIPCYFIDPMHPVTT 62
Query: 55 SYNTSEFL-RIKWSKIEVDKNGKDLKETTVLVAQNGNIKIGQDYKGRVSVPTHPEAVGDA 113
+ +T+ RIKWS++ +K E +LVA G +++ Y+ +VS+P +P DA
Sbjct: 63 APSTAPLAPRIKWSRVSKEK------EVVLLVATEGRVRVNSAYQDKVSLPNYPAIPSDA 116
Query: 114 SLTVVKLLASDAGLYRCDVMYGIEDTQDTVSLTVDGVVFHYRAATSRYTLNFEAAQKACL 173
+L V L ++D+G+YRC+VM+GIED++ T+ + V G+VFHYRA ++RYTL+F+ AQ+ACL
Sbjct: 117 TLEVQSLRSNDSGVYRCEVMHGIEDSEATLEVVVKGIVFHYRAISTRYTLDFDRAQRACL 176
Query: 174 DVGAVIATPEQLFAAYEDGFEQCDAGWLADQTVRYPIRAPRVGCYGDKMGKAGVRTYGFR 233
A+IATPEQL AAYEDGF QCDAGWLADQTVRYPI PR GCYGDK GVRTYG R
Sbjct: 177 QNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIR 236
Query: 234 SPQETYDVYCYVDHLDGDVFHLTVPSKFTFEEAAKECENQDARLATVGELQAAWRNGFDQ 293
ETYDVYC+ + ++G+VF+ T P KFTF+EAA EC ARLAT G+L AW+ G D
Sbjct: 237 DTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQAGMDM 296
Query: 294 CDYGWLSDASVRHPVTVARAQCGGGLLGVRTLYRFENQTGFPPPDSRFDAYCFKRPD 350
C GWL+D SVR+P++ AR CGG LLGVRT+Y NQTG+P P SR+DA C+ D
Sbjct: 297 CSAGWLADRSVRYPISKARPNCGGNLLGVRTVYVHANQTGYPDPSSRYDAICYTGED 353
Score = 255 bits (652), Expect = 8e-68
Identities = 120/199 (60%), Positives = 144/199 (72%)
Query: 149 GVVFHYRAATSRYTLNFEAAQKACLDVGAVIATPEQLFAAYEDGFEQCDAGWLADQTVRY 208
GVVFHYR +RY+L FE AQ+ACL GAVIA+PEQL AAYE G+EQCDAGWL DQTVRY
Sbjct: 477 GVVFHYRPGPTRYSLTFEEAQQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLRDQTVRY 536
Query: 209 PIRAPRVGCYGDKMGKAGVRTYGFRSPQETYDVYCYVDHLDGDVFHLTVPSKFTFEEAAK 268
PI +PR C GDK GVRTYG R ETYDVYC+VD L+G+VF T +FTF+EA +
Sbjct: 537 PIVSPRTPCVGDKDSSPGVRTYGVRPSTETYDVYCFVDRLEGEVFFATRLEQFTFQEALE 596
Query: 269 ECENQDARLATVGELQAAWRNGFDQCDYGWLSDASVRHPVTVARAQCGGGLLGVRTLYRF 328
CE+ +A LAT G+L AAW G D+C GWL+D S+R+P+ R CGG GVRT+Y +
Sbjct: 597 FCESHNATLATTGQLYAAWSRGLDKCYAGWLADGSLRYPIVTPRPACGGDKPGVRTVYLY 656
Query: 329 ENQTGFPPPDSRFDAYCFK 347
NQTG P P SR A+CF+
Sbjct: 657 PNQTGLPDPLSRHHAFCFR 675
Score = 209 bits (532), Expect = 6e-54
Identities = 86/129 (66%), Positives = 104/129 (80%)
Query: 424 DTETCDYGWHKFQGQCYKYFAHRRTWDAAERECRLQGAHLTSILSHEEQMFVNRVGHDYQ 483
D E C+ GW+K+QG CY++F R TW AER CR Q +HL+SI++ EEQ FVN DYQ
Sbjct: 2164 DQEVCEEGWNKYQGHCYRHFPDRETWVDAERRCREQQSHLSSIVTPEEQEFVNNNAQDYQ 2223
Query: 484 WIGLNDKMFEHDFRWTDGSTLQYENWRPNQPDSFFSAGEDCVVIIWHENGQWNDVPCNYH 543
WIGLND+ E DFRW+DG +Q+ENWRPNQPD+FF+AGEDCVV+IWHE G+WNDVPCNYH
Sbjct: 2224 WIGLNDRTIEGDFRWSDGHPMQFENWRPNQPDNFFAAGEDCVVMIWHEKGEWNDVPCNYH 2283
Query: 544 LTYTCKKGT 552
L +TCKKGT
Sbjct: 2284 LPFTCKKGT 2292
>gi|38372931 brevican isoform 2 [Homo sapiens]
Length = 671
Score = 322 bits (826), Expect = 5e-88
Identities = 151/325 (46%), Positives = 210/325 (64%), Gaps = 6/325 (1%)
Query: 23 KVKVGKSPPVRGSLSGKVSLPCHFSTMPTLPPSYNTSEFLRIKWSKIEVDKNGKDLKETT 82
+V++ P++G L G +++PCH + P R+KW+ + + E
Sbjct: 36 RVRIAGDAPLQGVLGGALTIPCHVHYLRPPPSRRAVLGSPRVKWTFLSRGR------EAE 89
Query: 83 VLVAQNGNIKIGQDYKGRVSVPTHPEAVGDASLTVVKLLASDAGLYRCDVMYGIEDTQDT 142
VLVA+ +K+ + Y+ RV++P +P ++ D SL + +L +D+G+YRC+V +GI+D+ D
Sbjct: 90 VLVARGVRVKVNEAYRFRVALPAYPASLTDVSLALSELRPNDSGIYRCEVQHGIDDSSDA 149
Query: 143 VSLTVDGVVFHYRAATSRYTLNFEAAQKACLDVGAVIATPEQLFAAYEDGFEQCDAGWLA 202
V + V GVVF YR ++RY +F AQ+AC +GA IATPEQL+AAY G+EQCDAGWL+
Sbjct: 150 VEVKVKGVVFLYREGSARYAFSFSGAQEACARIGAHIATPEQLYAAYLGGYEQCDAGWLS 209
Query: 203 DQTVRYPIRAPRVGCYGDKMGKAGVRTYGFRSPQETYDVYCYVDHLDGDVFHLTVPSKFT 262
DQTVRYPI+ PR CYGD G GVR YG P + YDVYCY + L+G++F P K T
Sbjct: 210 DQTVRYPIQTPREACYGDMDGFPGVRNYGVVDPDDLYDVYCYAEDLNGELFLGDPPEKLT 269
Query: 263 FEEAAKECENQDARLATVGELQAAWRNGFDQCDYGWLSDASVRHPVTVARAQCGGGLLGV 322
EEA C+ + A +AT G+L AAW G D C GWL+D SVR+P+ +CGGGL GV
Sbjct: 270 LEEARAYCQERGAEIATTGQLYAAWDGGLDHCSPGWLADGSVRYPIVTPSQRCGGGLPGV 329
Query: 323 RTLYRFENQTGFPPPDSRFDAYCFK 347
+TL+ F NQTGFP SRF+ YCF+
Sbjct: 330 KTLFLFPNQTGFPNKHSRFNVYCFR 354
>gi|38372935 brevican isoform 1 [Homo sapiens]
Length = 911
Score = 322 bits (826), Expect = 5e-88
Identities = 151/325 (46%), Positives = 210/325 (64%), Gaps = 6/325 (1%)
Query: 23 KVKVGKSPPVRGSLSGKVSLPCHFSTMPTLPPSYNTSEFLRIKWSKIEVDKNGKDLKETT 82
+V++ P++G L G +++PCH + P R+KW+ + + E
Sbjct: 36 RVRIAGDAPLQGVLGGALTIPCHVHYLRPPPSRRAVLGSPRVKWTFLSRGR------EAE 89
Query: 83 VLVAQNGNIKIGQDYKGRVSVPTHPEAVGDASLTVVKLLASDAGLYRCDVMYGIEDTQDT 142
VLVA+ +K+ + Y+ RV++P +P ++ D SL + +L +D+G+YRC+V +GI+D+ D
Sbjct: 90 VLVARGVRVKVNEAYRFRVALPAYPASLTDVSLALSELRPNDSGIYRCEVQHGIDDSSDA 149
Query: 143 VSLTVDGVVFHYRAATSRYTLNFEAAQKACLDVGAVIATPEQLFAAYEDGFEQCDAGWLA 202
V + V GVVF YR ++RY +F AQ+AC +GA IATPEQL+AAY G+EQCDAGWL+
Sbjct: 150 VEVKVKGVVFLYREGSARYAFSFSGAQEACARIGAHIATPEQLYAAYLGGYEQCDAGWLS 209
Query: 203 DQTVRYPIRAPRVGCYGDKMGKAGVRTYGFRSPQETYDVYCYVDHLDGDVFHLTVPSKFT 262
DQTVRYPI+ PR CYGD G GVR YG P + YDVYCY + L+G++F P K T
Sbjct: 210 DQTVRYPIQTPREACYGDMDGFPGVRNYGVVDPDDLYDVYCYAEDLNGELFLGDPPEKLT 269
Query: 263 FEEAAKECENQDARLATVGELQAAWRNGFDQCDYGWLSDASVRHPVTVARAQCGGGLLGV 322
EEA C+ + A +AT G+L AAW G D C GWL+D SVR+P+ +CGGGL GV
Sbjct: 270 LEEARAYCQERGAEIATTGQLYAAWDGGLDHCSPGWLADGSVRYPIVTPSQRCGGGLPGV 329
Query: 323 RTLYRFENQTGFPPPDSRFDAYCFK 347
+TL+ F NQTGFP SRF+ YCF+
Sbjct: 330 KTLFLFPNQTGFPNKHSRFNVYCFR 354
Score = 296 bits (758), Expect = 4e-80
Identities = 122/224 (54%), Positives = 163/224 (72%)
Query: 389 ECHSNPCRNGATCVDGFNTFRCLCLPSYVGALCEQDTETCDYGWHKFQGQCYKYFAHRRT 448
+C +PC NG TC++ RCLCLP Y G LC+ C+ GW FQG CYK+F+ RR+
Sbjct: 649 DCVPSPCHNGGTCLEEEEGVRCLCLPGYGGDLCDVGLRFCNPGWDAFQGACYKHFSTRRS 708
Query: 449 WDAAERECRLQGAHLTSILSHEEQMFVNRVGHDYQWIGLNDKMFEHDFRWTDGSTLQYEN 508
W+ AE +CR+ GAHL SI + EEQ F+N +YQWIGLND+ E DF W+DG L YEN
Sbjct: 709 WEEAETQCRMYGAHLASISTPEEQDFINNRYREYQWIGLNDRTIEGDFLWSDGVPLLYEN 768
Query: 509 WRPNQPDSFFSAGEDCVVIIWHENGQWNDVPCNYHLTYTCKKGTVACGQPPVVENAKTFG 568
W P QPDS+F +GE+CVV++WH+ GQW+DVPCNYHL+YTCK G V+CG PP + A+ FG
Sbjct: 769 WNPGQPDSYFLSGENCVVMVWHDQGQWSDVPCNYHLSYTCKMGLVSCGPPPELPLAQVFG 828
Query: 569 KMKPRYEINSLIRYHCKDGFIQRHLPTIRCLGNGRWAIPKITCM 612
+ + RYE+++++RY C++G QR+LP IRC NGRW P+I+C+
Sbjct: 829 RPRLRYEVDTVLRYRCREGLAQRNLPLIRCQENGRWEAPQISCV 872
>gi|4503053 hyaluronan and proteoglycan link protein 1 [Homo
sapiens]
Length = 354
Score = 217 bits (553), Expect = 2e-56
Identities = 126/313 (40%), Positives = 182/313 (58%), Gaps = 19/313 (6%)
Query: 38 GKVSLPCHFSTMPTLPPSYNTSEFLRIKWSKIEVDKNGKDLKETTVLVAQNGNIKIGQDY 97
G V+LPC F PT S +RIKW+K+ D LKE V V+ + K Y
Sbjct: 55 GNVTLPCKFYRDPTAFGS--GIHKIRIKWTKLTSDY----LKEVDVFVSMGYHKKTYGGY 108
Query: 98 KGRVSVPTHPEAVGDASLTVVKLLASDAGLYRCDVMYGIEDTQDTVSLTVDGVVFHYRAA 157
+GRV + ++ DASL + L D G Y+C+V+ G+ED V+L + GVVF Y
Sbjct: 109 QGRVFLKGGSDS--DASLVITDLTLEDYGRYKCEVIEGLEDDTVVVALDLQGVVFPYFPR 166
Query: 158 TSRYTLNFEAAQKACLDVGAVIATPEQLFAAYEDGFEQCDAGWLADQTVRYPIRAPRVGC 217
RY LNF AQ+ACLD AVIA+ +QL+ A+ G + C+AGWL+D +V+YPI PR C
Sbjct: 167 LGRYNLNFHEAQQACLDQDAVIASFDQLYDAWRGGLDWCNAGWLSDGSVQYPITKPREPC 226
Query: 218 YGDKMGKAGVRTYGFRSPQET-YDVYCYVDHLDGDVFHLTVPSKFTFEEAAKECENQDAR 276
G + GVR YGF ++ YDV+C+ + +G ++L P+K T++EA + C N A+
Sbjct: 227 -GGQNTVPGVRNYGFWDKDKSRYDVFCFTSNFNGRFYYLIHPTKLTYDEAVQACLNDGAQ 285
Query: 277 LATVGELQAAWR-NGFDQCDYGWLSDASVRHPVTVARAQCGGGLLGVRTLYRFENQTGFP 335
+A VG++ AAW+ G+D+CD GWL+D SVR+P++ R +C VR + GFP
Sbjct: 286 IAKVGQIFAAWKILGYDRCDAGWLADGSVRYPISRPRRRCSPTEAAVRFV-------GFP 338
Query: 336 PPDSR-FDAYCFK 347
+ + YCF+
Sbjct: 339 DKKHKLYGVYCFR 351
>gi|30102948 hyaluronan and proteoglycan link protein 3 [Homo
sapiens]
Length = 360
Score = 217 bits (552), Expect = 3e-56
Identities = 129/312 (41%), Positives = 176/312 (56%), Gaps = 21/312 (6%)
Query: 40 VSLPCHFSTMPTLPPSYNTSEFLRIKWSKIEVDKNGKDLKETTVLVAQNGNIKIGQDYKG 99
V LPC + P L + +R+KW K+ +NG K+ VLVA + DY+G
Sbjct: 66 VILPCRYRYEPALV----SPRRVRVKWWKLS--ENGAPEKD--VLVAIGLRHRSFGDYQG 117
Query: 100 RVSVPTHPEAVGDASLTVVKLLASDAGLYRCDVMYGIEDTQDTVSLTVDGVVFHYRAATS 159
RV + E D SL + L D G YRC+V+ G+ED V L + GVVF Y++
Sbjct: 118 RVHLRQDKEH--DVSLEIQDLRLEDYGRYRCEVIDGLEDESGLVELELRGVVFPYQSPNG 175
Query: 160 RYTLNFEAAQKACLDVGAVIATPEQLFAAYEDGFEQCDAGWLADQTVRYPIRAPRVGCYG 219
RY NF Q+ C + AV+A+ EQLF A+E+G + C+AGWL D TV+YPI PR C G
Sbjct: 176 RYQFNFHEGQQVCAEQAAVVASFEQLFRAWEEGLDWCNAGWLQDATVQYPIMLPRQPCGG 235
Query: 220 DKMGKAGVRTYGFRSPQ-ETYDVYCYVDHLDGDVFHLTVPSKFTFEEAAKECENQDARLA 278
+ GVR+YG R + YDV+C+ L G V++L P K T EA + C+ DA +A
Sbjct: 236 PGLA-PGVRSYGPRHRRLHRYDVFCFATALKGRVYYLEHPEKLTLTEAREACQEDDATIA 294
Query: 279 TVGELQAAWR-NGFDQCDYGWLSDASVRHPVTVARAQCGGGLLGVRTLYRFENQTGFPPP 337
VG+L AAW+ +G D+CD GWL+D SVR+PV CG GVR+ GFP P
Sbjct: 295 KVGQLFAAWKFHGLDRCDAGWLADGSVRYPVVHPHPNCGPPEPGVRSF-------GFPDP 347
Query: 338 DSR-FDAYCFKR 348
SR + YC+++
Sbjct: 348 QSRLYGVYCYRQ 359
>gi|11141887 brain link protein-1 [Homo sapiens]
Length = 340
Score = 194 bits (493), Expect = 2e-49
Identities = 115/310 (37%), Positives = 172/310 (55%), Gaps = 30/310 (9%)
Query: 41 SLPCHFSTMPTLPPSYNTSEFLRIKWSKIEVDKNGKDLKETTVLVAQNGNIKIGQDYKGR 100
+LPC + T PPSY +++WSK+E +L+ET +L+ + + GR
Sbjct: 54 TLPC---VLGTTPPSY------KVRWSKVEPG----ELRETLILITNGLHARGYGPLGGR 100
Query: 101 VSVPTHPEAVGDASLTVVKLLASDAGLYRCDVMYGIEDTQDTVSLTVDGVVFHYRAATSR 160
+ DASL + + D G YRC+++ GIED ++L+++GVVF Y+ + R
Sbjct: 101 ARMRRGHRL--DASLVIAGVRLEDEGRYRCELINGIEDESVALTLSLEGVVFPYQPSRGR 158
Query: 161 YTLNFEAAQKACLDVGAVIATPEQLFAAYEDGFEQCDAGWLADQTVRYPIRAPRVGCYGD 220
Y N+ A++AC + +AT QL+ A+ +G + C+AGWL + +VRYP+ R C G
Sbjct: 159 YQFNYYEAKQACEEQDGRLATYSQLYQAWTEGLDWCNAGWLLEGSVRYPVLTARAPCGG- 217
Query: 221 KMGKAGVRTYGFRS-PQETYDVYCYVDHLDGDVFHLTVPSKFTFEEAAKECENQDARLAT 279
G+ G+R+YG R ++ YD +C+ L G VF VP + T EA C + A +A
Sbjct: 218 -RGRPGIRSYGPRDRMRDRYDAFCFTSALAGQVFF--VPGRLTLSEAHAACRRRGAVVAK 274
Query: 280 VGELQAAWR-NGFDQCDYGWLSDASVRHPVTVARAQCGG-GLLGVRTLYRFENQTGFP-P 336
VG L AAW+ +G DQCD GWL+D SVR P+T R +CGG GVR+ GFP P
Sbjct: 275 VGHLYAAWKFSGLDQCDGGWLADGSVRFPITTPRPRCGGLPDPGVRSF-------GFPRP 327
Query: 337 PDSRFDAYCF 346
+ + YC+
Sbjct: 328 QQAAYGTYCY 337
>gi|30794472 hyaluronan and proteoglycan link protein 4 [Homo
sapiens]
Length = 402
Score = 194 bits (492), Expect = 3e-49
Identities = 120/324 (37%), Positives = 170/324 (52%), Gaps = 30/324 (9%)
Query: 38 GKVSLPCHFSTMPTLPPSYNTSEFLRIKWSKIEVDKNGKDLKETTVLVAQNGNIKIGQDY 97
G + LPC + + + + +R+KW+K+ VD L T V VA + Y
Sbjct: 62 GTIVLPCRYH----YEAAAHGHDGVRLKWTKV-VDP----LAFTDVFVALGPQHRAFGSY 112
Query: 98 KGRVSVPTHPEAVGDASLTVVKLLASDAGLYRCDVMYGIEDTQDTVSLTVDGVVFHYRAA 157
+GR + + GDASL + + D G Y C+V +ED V L ++GVVF Y
Sbjct: 113 RGRAEL--QGDGPGDASLVLRNVTLQDYGRYECEVTNELEDDAGMVKLDLEGVVFPYHPR 170
Query: 158 TSRYTLNFEAAQKACLDVGAVIATPEQLFAAYEDGFEQCDAGWLADQTVRYPIRAPRVGC 217
RY L F AQ+AC + ++A+ EQL AA+ DG + C+AGWL D +V+YP+ PR C
Sbjct: 171 GGRYKLTFAEAQRACAEQDGILASAEQLHAAWRDGLDWCNAGWLRDGSVQYPVNRPREPC 230
Query: 218 YG-DKMGKA--------GVRTYGFR-SPQETYDVYCYVDHLDGDVFHLTVPSKFTFEEAA 267
G G A G+R YG+R + +E YD +C+ +L G VF L F AA
Sbjct: 231 GGLGGTGSAGGGGDANGGLRNYGYRHNAEERYDAFCFTSNLPGRVFFLKPLRPVPFSGAA 290
Query: 268 KECENQDARLATVGELQAAWR-NGFDQCDYGWLSDASVRHPVTVARAQCGGGLLGVRTLY 326
+ C + A +A VG+L AAW+ D+C GWL+D S R+P+ RA+CGG GVR+L
Sbjct: 291 RACAARGAAVAKVGQLFAAWKLQLLDRCTAGWLADGSARYPIVNPRARCGGRRPGVRSL- 349
Query: 327 RFENQTGFPPPDSR-FDAYCFKRP 349
GFP R F YC++ P
Sbjct: 350 ------GFPDATRRLFGVYCYRAP 367
>gi|110624774 mannose receptor, C type 2 [Homo sapiens]
Length = 1479
Score = 109 bits (272), Expect = 9e-24
Identities = 50/126 (39%), Positives = 73/126 (57%), Gaps = 4/126 (3%)
Query: 428 CDYGWHKFQGQCYKYFAHRRTWDAAERECRLQGAHLTSILSHEEQMFVNR-VGHDYQ--W 484
C+ W FQG CY+ A +R+W +++ C G L SI S E F+ + + + + W
Sbjct: 382 CEPSWQPFQGHCYRLQAEKRSWQESKKACLRGGGDLVSIHSMAELEFITKQIKQEVEELW 441
Query: 485 IGLNDKMFEHDFRWTDGSTLQYENWRPNQPDSFFSAGEDCVVIIWHENGQWNDVPCNYHL 544
IGLND + +F W+DGS + + +W P +P++F + EDCV IW G+WND PCN L
Sbjct: 442 IGLNDLKLQMNFEWSDGSLVSFTHWHPFEPNNFRDSLEDCVT-IWGPEGRWNDSPCNQSL 500
Query: 545 TYTCKK 550
CKK
Sbjct: 501 PSICKK 506
Score = 87.4 bits (215), Expect = 4e-17
Identities = 51/144 (35%), Positives = 71/144 (49%), Gaps = 8/144 (5%)
Query: 421 CEQDTETCDYGWHKFQ--GQCYKY-FAHRRTWDAAERECRLQGAHLTSILSHEEQMFVNR 477
C + C+ W K Q CY++ F +W A C QGA L SI EQ ++N
Sbjct: 228 CPIKSNDCETFWDKDQLTDSCYQFNFQSTLSWREAWASCEQQGADLLSITEIHEQTYING 287
Query: 478 VGHDYQ---WIGLNDKMFEHDFRWTDGSTLQYENWRPNQPDSFFSAGEDCVVIIWHENGQ 534
+ Y WIGLND ++W+D S L+Y NW +QPD+ + E+C VI +G
Sbjct: 288 LLTGYSSTLWIGLNDLDTSGGWQWSDNSPLKYLNWESDQPDN--PSEENCGVIRTESSGG 345
Query: 535 WNDVPCNYHLTYTCKKGTVACGQP 558
W + C+ L Y CKK A +P
Sbjct: 346 WQNRDCSIALPYVCKKKPNATAEP 369
Score = 79.0 bits (193), Expect = 1e-14
Identities = 51/139 (36%), Positives = 66/139 (47%), Gaps = 16/139 (11%)
Query: 432 WHKFQGQCYKYFAHRRTWDAAERECRLQGAHLTSI--------LSHEEQMFVNRVGHDYQ 483
W +FQ YK+F H TW A+R C A LTS+ LSH Q F +R +
Sbjct: 829 WLRFQEAEYKFFEHHSTWAQAQRICTWFQAELTSVHSQAELDFLSHNLQKF-SRAQEQHW 887
Query: 484 WIGLNDKMFEHDFRWTDGSTLQYENWRPNQPDSFFSAGED--CVVIIWHENGQWNDVPCN 541
WIGL+ + FRWTDGS + + +W P +P G+D CV + W D C
Sbjct: 888 WIGLHTSESDGRFRWTDGSIINFISWAPGKPR---PVGKDKKCVYMT-ASREDWGDQRCL 943
Query: 542 YHLTYTCKKGTVAC-GQPP 559
L Y CK+ V QPP
Sbjct: 944 TALPYICKRSNVTKETQPP 962
Score = 60.8 bits (146), Expect = 4e-09
Identities = 42/143 (29%), Positives = 61/143 (42%), Gaps = 21/143 (14%)
Query: 428 CDYGWHKFQGQCYKYFAH----RRTWDAAERECRLQGAHLTSILSHEEQMFVN----RVG 479
C W +F +C++ R W A+ C Q A L +I + EQ F+ V
Sbjct: 972 CPSDWIQFLNKCFQVQGQEPQSRVKWSEAQFSCEQQEAQLVTITNPLEQAFITASLPNVT 1031
Query: 480 HDYQWIGLNDKMFEHDFRWTDGSTLQYENWRPNQPDSFFSAGE-----DCVVIIW----H 530
D WIGL+ + DF+W + L Y NW P +P A C V++ H
Sbjct: 1032 FDL-WIGLHAS--QRDFQWVEQEPLMYANWAPGEPSGPSPAPSGNKPTSCAVVLHSPSAH 1088
Query: 531 ENGQWNDVPCNYHL-TYTCKKGT 552
G+W+D C + C+KGT
Sbjct: 1089 FTGRWDDRSCTEETHGFICQKGT 1111
Score = 53.9 bits (128), Expect = 5e-07
Identities = 44/147 (29%), Positives = 66/147 (44%), Gaps = 25/147 (17%)
Query: 425 TETCDYGWHKFQG--QCYKYFAHRR-----TWDAAERECRLQGAHLTSILSHEEQMFV-- 475
T +C GW CYK F+ R +W A+ C+ GA L S+ S+EE+ FV
Sbjct: 666 TGSCPQGWASDTKLRYCYKVFSSERLQDKKSWVQAQGACQELGAQLLSLASYEEEHFVAN 725
Query: 476 --NRVGHDYQ---------WIGLN--DKMFEHDFRWTDGSTLQYENWRPNQPDSFFSAGE 522
N++ + + WIGLN D +RW+DG Y N+ ++ D G
Sbjct: 726 MLNKIFGESEPEIHEQHWFWIGLNRRDPRGGQSWRWSDGVGFSYHNFDRSRHDDDDIRG- 784
Query: 523 DCVVIIWHENGQWNDVPCNYHLTYTCK 549
C V+ + QW + C+ L + CK
Sbjct: 785 -CAVLDL-ASLQWVAMQCDTQLDWICK 809
Score = 53.5 bits (127), Expect = 6e-07
Identities = 34/133 (25%), Positives = 54/133 (40%), Gaps = 7/133 (5%)
Query: 423 QDTETCDYGWHKFQGQCYKYFAHRRTWDAAERECRLQGAHLTSILSHEEQMFVNRVGH-- 480
++ C GW CY + T+ A R C G+ L +I + EQ FV+ + +
Sbjct: 516 EEDHGCRKGWTWHSPSCYWLGEDQVTYSEARRLCTDHGSQLVTITNRFEQAFVSSLIYNW 575
Query: 481 --DYQWIGLNDKMFEHDFRWTDGSTLQYENWRPNQPDSFFSAGEDCVVIIWHENGQWNDV 538
+Y W L D F W G + Y +W +QP +S G + G W
Sbjct: 576 EGEYFWTALQDLNSTGSFFWLSGDEVMYTHWNRDQPG--YSRGGCVALATGSAMGLWEVK 633
Query: 539 PC-NYHLTYTCKK 550
C ++ Y C++
Sbjct: 634 NCTSFRARYICRQ 646
Score = 43.1 bits (100), Expect = 8e-04
Identities = 38/147 (25%), Positives = 54/147 (36%), Gaps = 20/147 (13%)
Query: 415 SYVGALCEQDTETCDYGWHKFQGQCYKY-----FAHRRTWDAAERECRLQGAHLTSILSH 469
SY G+ C Q D W F+ CY + H+ A + C+ G + SIL
Sbjct: 1256 SYHGS-CPQGL--ADSAWIPFREHCYSFHMELLLGHKE----ARQRCQRAGGAVLSILDE 1308
Query: 470 EEQMFVNRVGHDYQ------WIGLNDKMFEHDFRWTDGSTLQYENWRPNQPDSFFSAGED 523
E +FV Y+ W+G+N W D + + Y NW P +
Sbjct: 1309 MENVFVWEHLQSYEGQSRGAWLGMNFNPKGGTLVWQDNTAVNYSNWGPPGLGPSMLSHNS 1368
Query: 524 CVVIIWHENGQWNDVPC-NYHLTYTCK 549
C I +G W C N + CK
Sbjct: 1369 C-YWIQSNSGLWRPGACTNITMGVVCK 1394
Score = 30.0 bits (66), Expect = 7.0
Identities = 26/115 (22%), Positives = 39/115 (33%), Gaps = 13/115 (11%)
Query: 449 WDAAERECRLQGAHLTSILSHEEQMFVNRVGHDYQ---WIGLNDKMFEHDFRWTDGSTLQ 505
W A C + A L + Q F+ + + WIGL + + W L
Sbjct: 1146 WHDALLLCESRNASLAYVPDPYTQAFLTQAARGLRTPLWIGLAGEEGSRRYSWVSEEPLN 1205
Query: 506 YENWRPNQPDSFFSAGEDCVVIIWHENGQWNDVPCNYHLT-YTCKKGTVACGQPP 559
Y W+ +P C + +G W C+ L C V+ G PP
Sbjct: 1206 YVGWQDGEPQQ----PGGCTYV--DVDGAWRTTSCDTKLQGAVC---GVSSGPPP 1251
>gi|24041035 notch 2 preproprotein [Homo sapiens]
Length = 2471
Score = 108 bits (271), Expect = 1e-23
Identities = 45/93 (48%), Positives = 57/93 (61%)
Query: 350 DRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFR 409
D C PC+N G C+ T+ SY+C C PG+SG CE D D+C +NPC+NG +C+DG NTF
Sbjct: 875 DECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFS 934
Query: 410 CLCLPSYVGALCEQDTETCDYGWHKFQGQCYKY 442
CLCLP + G C+ D C K G C Y
Sbjct: 935 CLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDY 967
Score = 104 bits (260), Expect = 2e-22
Identities = 45/98 (45%), Positives = 57/98 (58%), Gaps = 1/98 (1%)
Query: 343 AYCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCV 402
+YC ++ D C NPC +G TC Y C CVPGY G CE + DEC + PC+NG TC+
Sbjct: 1144 SYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCI 1203
Query: 403 DGFNTFRCLCLPSYVGALCEQDTETCDYGWHKFQ-GQC 439
D N F+C C P G LCE++ + C G H GQC
Sbjct: 1204 DLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQC 1241
Score = 99.0 bits (245), Expect = 1e-20
Identities = 43/106 (40%), Positives = 59/106 (55%), Gaps = 3/106 (2%)
Query: 337 PDSRFDAYCFKRPDRCKM---NPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSN 393
P A C + D C M NPC + G C T+ ++ C C+ GY+G +CE+D +ECHS+
Sbjct: 404 PQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSD 463
Query: 394 PCRNGATCVDGFNTFRCLCLPSYVGALCEQDTETCDYGWHKFQGQC 439
PC+N ATC+D F CLC+P + G CE + C GQC
Sbjct: 464 PCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQC 509
Score = 97.8 bits (242), Expect = 3e-20
Identities = 60/189 (31%), Positives = 85/189 (44%), Gaps = 18/189 (9%)
Query: 248 LDGDVFHLTVPSKFTFEEAAKECENQDARLA---TVGELQAAWRNGFD-QCDYGWLS--- 300
L D + T FT KEC+ DA L+ G N F +C G+
Sbjct: 124 LSRDTYECTCQVGFT----GKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKC 179
Query: 301 DASVRHPVTVARAQCGGGLLGVRTLYRFENQTGFPPPDSRFDAYCFKRPDRCKMNPCLNG 360
+ V Q GG L + Y+ + GF YC C +PC+NG
Sbjct: 180 ETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFT------GQYCDSLYVPCAPSPCVNG 233
Query: 361 GTCYPT-ETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFRCLCLPSYVGA 419
GTC T + ++ C C+PG+ G CE + D+C ++ C+NG CVDG NT+ C C P + G
Sbjct: 234 GTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQ 293
Query: 420 LCEQDTETC 428
C +D + C
Sbjct: 294 FCTEDVDEC 302
Score = 94.4 bits (233), Expect = 3e-19
Identities = 34/86 (39%), Positives = 50/86 (58%)
Query: 344 YCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVD 403
+C + C+ NPC+N G C + C C PG++G C++D D+C S PC NGA C+D
Sbjct: 490 HCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCID 549
Query: 404 GFNTFRCLCLPSYVGALCEQDTETCD 429
N + C C + G LCE++ + CD
Sbjct: 550 HPNGYECQCATGFTGVLCEENIDNCD 575
Score = 93.6 bits (231), Expect = 5e-19
Identities = 39/94 (41%), Positives = 54/94 (57%), Gaps = 2/94 (2%)
Query: 335 PPPDSRFDAYCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNP 394
PP S D C + D C NPC NGG+C ++ C C+PG++GD+C+ D +EC S P
Sbjct: 900 PPGFSGMD--CEEDIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSEP 957
Query: 395 CRNGATCVDGFNTFRCLCLPSYVGALCEQDTETC 428
C+NG TC D N++ C C + G CE + C
Sbjct: 958 CKNGGTCSDYVNSYTCKCQAGFDGVHCENNINEC 991
Score = 92.4 bits (228), Expect = 1e-18
Identities = 38/86 (44%), Positives = 49/86 (56%), Gaps = 1/86 (1%)
Query: 343 AYCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCV 402
A C + D C +PCLN G C Y C C PG SG CE++FD+C SNPC +G C+
Sbjct: 602 AICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIHG-ICM 660
Query: 403 DGFNTFRCLCLPSYVGALCEQDTETC 428
DG N + C+C P + G C D + C
Sbjct: 661 DGINRYSCVCSPGFTGQRCNIDIDEC 686
Score = 90.5 bits (223), Expect = 4e-18
Identities = 34/79 (43%), Positives = 46/79 (58%)
Query: 350 DRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFR 409
+ C +PC N TC + C C+PG+ G CEL+ +EC SNPC N CVD N F+
Sbjct: 458 NECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQ 517
Query: 410 CLCLPSYVGALCEQDTETC 428
CLC P + G +C+ D + C
Sbjct: 518 CLCPPGFTGPVCQIDIDDC 536
Score = 86.7 bits (213), Expect = 6e-17
Identities = 52/150 (34%), Positives = 72/150 (48%), Gaps = 13/150 (8%)
Query: 290 GFDQCDYGWLSD-ASVRHPVTVARAQCGGGLLGVRTLYRFENQ--TGFPPPDSRFDAY-- 344
G+ +C G+L + R P R Q GG + L + + +GF D ++
Sbjct: 49 GYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHP 108
Query: 345 CFKRPDRCKMNPCLNGGTCYP-TETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVD 403
CF PCLNGGTC+ + +Y CTC G++G +C+ D C S+PC NG+TC
Sbjct: 109 CFVS------RPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTT 161
Query: 404 GFNTFRCLCLPSYVGALCEQDTETCDYGWH 433
N F C CL + G CE D CD H
Sbjct: 162 VANQFSCKCLTGFTGQKCETDVNECDIPGH 191
Score = 85.9 bits (211), Expect = 1e-16
Identities = 35/84 (41%), Positives = 44/84 (52%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDG 404
C + C PC NGGTC SY C C G+ G CE + +EC + C NG TCVDG
Sbjct: 946 CQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDG 1005
Query: 405 FNTFRCLCLPSYVGALCEQDTETC 428
N+F CLC + G+ C + C
Sbjct: 1006 INSFSCLCPVGFTGSFCLHEINEC 1029
Score = 85.1 bits (209), Expect = 2e-16
Identities = 33/63 (52%), Positives = 42/63 (66%), Gaps = 1/63 (1%)
Query: 350 DRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFR 409
D C NPC++G C Y C C PG++G +C +D DEC SNPCR GATC++G N FR
Sbjct: 647 DDCASNPCIHG-ICMDGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINGVNGFR 705
Query: 410 CLC 412
C+C
Sbjct: 706 CIC 708
Score = 82.8 bits (203), Expect = 9e-16
Identities = 36/96 (37%), Positives = 48/96 (50%)
Query: 344 YCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVD 403
+C + C + C NGGTC S+ C C G++G C + +EC S+PC N TCVD
Sbjct: 983 HCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECSSHPCLNEGTCVD 1042
Query: 404 GFNTFRCLCLPSYVGALCEQDTETCDYGWHKFQGQC 439
G T+RC C Y G C+ C K +G C
Sbjct: 1043 GLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTC 1078
Score = 82.0 bits (201), Expect = 2e-15
Identities = 35/96 (36%), Positives = 48/96 (50%), Gaps = 7/96 (7%)
Query: 333 GFPPPDSRFDAYCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHS 392
GF P + D D C PCLNG C Y C C G++G CE + D C
Sbjct: 523 GFTGPVCQIDI------DDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDP 576
Query: 393 NPCRNGATCVDGFNTFRCLCLPSYVGALCEQDTETC 428
+PC +G C DG +++ C+C P Y+GA+C + C
Sbjct: 577 DPCHHG-QCQDGIDSYTCICNPGYMGAICSDQIDEC 611
Score = 81.6 bits (200), Expect = 2e-15
Identities = 46/139 (33%), Positives = 62/139 (44%), Gaps = 10/139 (7%)
Query: 294 CDYGWLS-DASVRHPVTVAR-AQCGGGLLGVRTLYRFENQTGFPPPDSRFDAYCFKRPDR 351
CD GW+ + V ++ Q GG + YR + GF + C D
Sbjct: 745 CDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYN------CQVNIDE 798
Query: 352 CKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVD--GFNTFR 409
C NPCLN GTC+ + Y C CV Y+G C+ C NPC N A C + F ++
Sbjct: 799 CASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFESYT 858
Query: 410 CLCLPSYVGALCEQDTETC 428
CLC P + G C D + C
Sbjct: 859 CLCAPGWQGQRCTIDIDEC 877
Score = 81.3 bits (199), Expect = 3e-15
Identities = 47/140 (33%), Positives = 56/140 (40%), Gaps = 10/140 (7%)
Query: 294 CDYGWLSDASVRHPVTVARAQCGGGLLGVRTLYRFENQTGFPPPDSRFDAYCFKRPDRCK 353
C GW D + A A C G + + F P+ + C D C
Sbjct: 326 CVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMC----PEGKAGLLCHL-DDACI 380
Query: 354 MNPCLNGGTC--YPTETSYVCTCVPGYSGDQCELDFDEC---HSNPCRNGATCVDGFNTF 408
NPC G C P Y+CTC GY G C D DEC +SNPC + CV+ F
Sbjct: 381 SNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAF 440
Query: 409 RCLCLPSYVGALCEQDTETC 428
C CL Y G CE D C
Sbjct: 441 HCECLKGYAGPRCEMDINEC 460
Score = 80.1 bits (196), Expect = 6e-15
Identities = 36/104 (34%), Positives = 54/104 (51%), Gaps = 1/104 (0%)
Query: 337 PDSRFDAYCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCR 396
P+ C+ + + C NPC++G C + Y C C G+ G CE+D +EC SNPC+
Sbjct: 709 PEGPHHPSCYSQVNECLSNPCIHGN-CTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQ 767
Query: 397 NGATCVDGFNTFRCLCLPSYVGALCEQDTETCDYGWHKFQGQCY 440
NG TC + N +RC C + G C+ + + C QG C+
Sbjct: 768 NGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCF 811
Score = 80.1 bits (196), Expect = 6e-15
Identities = 34/89 (38%), Positives = 45/89 (50%)
Query: 357 CLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFRCLCLPSY 416
C + G C ++ C C GY+G CE DEC SNPC++GATC D +RC C+P Y
Sbjct: 1120 CQHSGVCINAGNTHYCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGY 1179
Query: 417 VGALCEQDTETCDYGWHKFQGQCYKYFAH 445
G CE + + C + G C H
Sbjct: 1180 QGVNCEYEVDECQNQPCQNGGTCIDLVNH 1208
Score = 77.4 bits (189), Expect = 4e-14
Identities = 35/93 (37%), Positives = 45/93 (48%), Gaps = 2/93 (2%)
Query: 344 YCFKRPDRCKMNP--CLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATC 401
+C + D C + P C NGGTC Y C CV G+SGD C + D+C C G+TC
Sbjct: 294 FCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTC 353
Query: 402 VDGFNTFRCLCLPSYVGALCEQDTETCDYGWHK 434
+D +F C+C G LC D HK
Sbjct: 354 IDRVASFSCMCPEGKAGLLCHLDDACISNPCHK 386
Score = 77.4 bits (189), Expect = 4e-14
Identities = 36/96 (37%), Positives = 52/96 (54%), Gaps = 4/96 (4%)
Query: 336 PPDSRFDAYCFKRPDRCKMNP-CLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNP 394
PP +R C + D C P CLNGG C Y C C+PG++G++CE D +EC SNP
Sbjct: 1214 PPGTR-GLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGDINECLSNP 1272
Query: 395 CRNGAT--CVDGFNTFRCLCLPSYVGALCEQDTETC 428
C + + C+ N + C+C ++ G CE + C
Sbjct: 1273 CSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVC 1308
Score = 75.9 bits (185), Expect = 1e-13
Identities = 31/87 (35%), Positives = 46/87 (52%)
Query: 343 AYCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCV 402
++C + C +PCLN GTC +Y C+C GY+G C+ + C +PC+N TCV
Sbjct: 1020 SFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCV 1079
Query: 403 DGFNTFRCLCLPSYVGALCEQDTETCD 429
+CLC + GA C+ +CD
Sbjct: 1080 QKKAESQCLCPSGWAGAYCDVPNVSCD 1106
Score = 74.3 bits (181), Expect = 3e-13
Identities = 33/84 (39%), Positives = 43/84 (51%), Gaps = 1/84 (1%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDG 404
C + D C +PC + G C SY C C PGY G C DEC+S+PC N C+D
Sbjct: 567 CEENIDNCDPDPC-HHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDL 625
Query: 405 FNTFRCLCLPSYVGALCEQDTETC 428
N ++C C P G CE + + C
Sbjct: 626 VNGYQCNCQPGTSGVNCEINFDDC 649
Score = 68.2 bits (165), Expect = 2e-11
Identities = 29/88 (32%), Positives = 44/88 (50%), Gaps = 2/88 (2%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDEC--HSNPCRNGATCV 402
C + D C + C NGG C +Y C C P ++G C D DEC N C+NG TC
Sbjct: 257 CERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCA 316
Query: 403 DGFNTFRCLCLPSYVGALCEQDTETCDY 430
+ + C+C+ + G C ++ + C +
Sbjct: 317 NRNGGYGCVCVNGWSGDDCSENIDDCAF 344
Score = 66.6 bits (161), Expect = 7e-11
Identities = 30/79 (37%), Positives = 37/79 (46%), Gaps = 1/79 (1%)
Query: 350 DRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFR 409
D C NPC G TC + C C G C +EC SNPC +G C G + ++
Sbjct: 684 DECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHG-NCTGGLSGYK 742
Query: 410 CLCLPSYVGALCEQDTETC 428
CLC +VG CE D C
Sbjct: 743 CLCDAGWVGINCEVDKNEC 761
Score = 56.6 bits (135), Expect = 7e-08
Identities = 27/72 (37%), Positives = 34/72 (47%), Gaps = 6/72 (8%)
Query: 344 YCFKRPDRCKMNPCLNGGTCYPTET---SYVCTCVPGYSGDQCELDFDECHSNPCRNGAT 400
+C D C PCLNGGTC ++C C PG+SG +C+ C CR G
Sbjct: 1300 HCETFVDVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQ---SSCGQVKCRKGEQ 1356
Query: 401 CVDGFNTFRCLC 412
CV + RC C
Sbjct: 1357 CVHTASGPRCFC 1368
Score = 43.1 bits (100), Expect = 8e-04
Identities = 28/110 (25%), Positives = 42/110 (38%), Gaps = 12/110 (10%)
Query: 352 CKMNPCLNGGTCYPTETS--YVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFR 409
C +PC +GG+C+P Y C C P +SG +CEL + P ATC+ + +
Sbjct: 1378 CASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCEL----YTAPPSTPPATCLSQYCADK 1433
Query: 410 C---LCLPSYVGALCEQDTETCDYGWHKFQGQCYKYFAHRRTWDAAEREC 456
+C + C+ D C C WD +C
Sbjct: 1434 ARDGVCDEACNSHACQWDGGDCSLTMENPWANCSSPLP---CWDYINNQC 1480
>gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
Length = 1200
Score = 99.8 bits (247), Expect = 7e-21
Identities = 44/103 (42%), Positives = 54/103 (52%), Gaps = 7/103 (6%)
Query: 337 PDSRFDAYCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCR 396
PD C K C NPC NGG+C+ + + C C G+SG C LD DEC SNPC
Sbjct: 336 PDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCA 395
Query: 397 NGATCVDGFNTFRCLCLPSYVGALCEQDTETCDYGWHKFQGQC 439
G TCVD + F C+C +VGA C+ D C +GQC
Sbjct: 396 AGGTCVDQVDGFECICPEQWVGATCQLDVNDC-------RGQC 431
Score = 84.3 bits (207), Expect = 3e-16
Identities = 35/93 (37%), Positives = 48/93 (51%)
Query: 336 PPDSRFDAYCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPC 395
PP + + C NPC+NGGTC + S+ C C G+ G C + ++C+ PC
Sbjct: 701 PPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPC 760
Query: 396 RNGATCVDGFNTFRCLCLPSYVGALCEQDTETC 428
NG CVDG N FRC C P + G C + + C
Sbjct: 761 YNGGICVDGVNWFRCECAPGFAGPDCRINIDEC 793
Score = 84.3 bits (207), Expect = 3e-16
Identities = 33/79 (41%), Positives = 43/79 (54%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDG 404
C + C PC NGG C + C C PG++G C ++ DEC S+PC GATCVD
Sbjct: 748 CTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDE 807
Query: 405 FNTFRCLCLPSYVGALCEQ 423
N +RC C P G C++
Sbjct: 808 INGYRCSCPPGRAGPRCQE 826
Score = 80.1 bits (196), Expect = 6e-15
Identities = 48/153 (31%), Positives = 65/153 (42%), Gaps = 6/153 (3%)
Query: 289 NGFD-QCDYGWLSDASVRHPVTVARAQCGGGLLGVRTLYRFENQTGFPPPDSRFDAYCFK 347
+GF+ C GW A C G V + FE P+ A C
Sbjct: 367 SGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECIC----PEQWVGATCQL 422
Query: 348 RPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNT 407
+ C+ C +GGTC Y C C G+ G CEL+ DEC S+PC +G C D +
Sbjct: 423 DVNDCR-GQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADG 481
Query: 408 FRCLCLPSYVGALCEQDTETCDYGWHKFQGQCY 440
F C C + G LCE D + C+ + +CY
Sbjct: 482 FHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCY 514
Score = 75.9 bits (185), Expect = 1e-13
Identities = 32/86 (37%), Positives = 44/86 (51%), Gaps = 1/86 (1%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDE-CHSNPCRNGATCVD 403
C R +C C NGGTCY + ++ C C PG+ G C + + C NPC NG TCV
Sbjct: 671 CHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVG 730
Query: 404 GFNTFRCLCLPSYVGALCEQDTETCD 429
+F C+C + G C +T C+
Sbjct: 731 SGASFSCICRDGWEGRTCTHNTNDCN 756
Score = 74.7 bits (182), Expect = 2e-13
Identities = 44/140 (31%), Positives = 59/140 (42%), Gaps = 9/140 (6%)
Query: 294 CDYGWLSDASVRHPVTVARAQC--GGGLLGVRTLYRFENQTGFPPPDSRFDAYCFKRPDR 351
C W+ A+ + V R QC GG + Y+ GF +C D
Sbjct: 411 CPEQWVG-ATCQLDVNDCRGQCQHGGTCKDLVNGYQCVCPRGFG------GRHCELERDE 463
Query: 352 CKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFRCL 411
C +PC +GG C + C C G+SG CE+D D C +PCRNGA C + + C
Sbjct: 464 CASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCA 523
Query: 412 CLPSYVGALCEQDTETCDYG 431
C + G C E C G
Sbjct: 524 CPDDFGGKNCSVPREPCPGG 543
Score = 72.8 bits (177), Expect = 9e-13
Identities = 35/104 (33%), Positives = 47/104 (45%), Gaps = 1/104 (0%)
Query: 338 DSRFDA-YCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCR 396
DS F YC + D C PC NGGTC ++ C C G+ G+ C+ + ++C +PC
Sbjct: 587 DSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCH 646
Query: 397 NGATCVDGFNTFRCLCLPSYVGALCEQDTETCDYGWHKFQGQCY 440
+ C D N F C C + G C CD G CY
Sbjct: 647 SRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCY 690
Score = 70.1 bits (170), Expect = 6e-12
Identities = 28/77 (36%), Positives = 38/77 (49%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDG 404
C P+ C +PC + G CY + C C G+ G C +C + C NG TC D
Sbjct: 633 CDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDS 692
Query: 405 FNTFRCLCLPSYVGALC 421
+TFRC C P + G+ C
Sbjct: 693 GDTFRCACPPGWKGSTC 709
Score = 67.8 bits (164), Expect = 3e-11
Identities = 40/132 (30%), Positives = 57/132 (43%), Gaps = 13/132 (9%)
Query: 309 TVARAQCGGGLLGVRTLYRFENQTGFPPPDSRFDAYCFKRPDRCKMNPCLNGGTCYPTET 368
+V R C GG R + + G P + C RC P GG
Sbjct: 534 SVPREPCPGG--ACRVIDGCGSDAGPGMPGTAASGVCGPH-GRCVSQP---GG------- 580
Query: 369 SYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFRCLCLPSYVGALCEQDTETC 428
++ C C G++G C + D+C PCRNG TC+D + FRC C + G LC+ + C
Sbjct: 581 NFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDC 640
Query: 429 DYGWHKFQGQCY 440
+G+CY
Sbjct: 641 LPDPCHSRGRCY 652
Score = 51.2 bits (121), Expect = 3e-06
Identities = 29/95 (30%), Positives = 43/95 (45%), Gaps = 7/95 (7%)
Query: 350 DRCKMNP-CLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHS-NPCRNGATCVDGF-N 406
D C P C++G P + C C + G C+ D + C S +PC NG TC++ +
Sbjct: 274 DECVPYPGCVHGSCVEPWQ----CNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPD 329
Query: 407 TFRCLCLPSYVGALCEQDTETCDYGWHKFQGQCYK 441
+RC C Y G CE+ C G C++
Sbjct: 330 QYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHE 364
Score = 50.8 bits (120), Expect = 4e-06
Identities = 24/103 (23%), Positives = 35/103 (33%), Gaps = 24/103 (23%)
Query: 350 DRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCR------------- 396
D C+ +PC NG CY E Y C C + G C + + C CR
Sbjct: 500 DLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGM 559
Query: 397 -----------NGATCVDGFNTFRCLCLPSYVGALCEQDTETC 428
+G F C+C + G C ++ + C
Sbjct: 560 PGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDC 602
Score = 35.8 bits (81), Expect = 0.13
Identities = 23/71 (32%), Positives = 33/71 (46%), Gaps = 11/71 (15%)
Query: 358 LNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFRCLCLPSYV 417
L+GG P E C C G+ G C DEC P +CV+ ++C C ++
Sbjct: 252 LHGGCTVPGE----CRCSYGWQGRFC----DECVPYPGCVHGSCVE---PWQCNCETNWG 300
Query: 418 GALCEQDTETC 428
G LC++D C
Sbjct: 301 GLLCDKDLNYC 311
>gi|21704277 jagged 2 isoform a precursor [Homo sapiens]
Length = 1238
Score = 99.4 bits (246), Expect = 9e-21
Identities = 41/93 (44%), Positives = 51/93 (54%)
Query: 337 PDSRFDAYCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCR 396
PD C K C NPC NGG+C+ + + C C G+SG C LD DEC SNPC
Sbjct: 336 PDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCA 395
Query: 397 NGATCVDGFNTFRCLCLPSYVGALCEQDTETCD 429
G TCVD + F C+C +VGA C+ D C+
Sbjct: 396 AGGTCVDQVDGFECICPEQWVGATCQLDANECE 428
Score = 84.3 bits (207), Expect = 3e-16
Identities = 35/93 (37%), Positives = 48/93 (51%)
Query: 336 PPDSRFDAYCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPC 395
PP + + C NPC+NGGTC + S+ C C G+ G C + ++C+ PC
Sbjct: 739 PPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPC 798
Query: 396 RNGATCVDGFNTFRCLCLPSYVGALCEQDTETC 428
NG CVDG N FRC C P + G C + + C
Sbjct: 799 YNGGICVDGVNWFRCECAPGFAGPDCRINIDEC 831
Score = 84.3 bits (207), Expect = 3e-16
Identities = 33/79 (41%), Positives = 43/79 (54%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDG 404
C + C PC NGG C + C C PG++G C ++ DEC S+PC GATCVD
Sbjct: 786 CTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDE 845
Query: 405 FNTFRCLCLPSYVGALCEQ 423
N +RC C P G C++
Sbjct: 846 INGYRCSCPPGRAGPRCQE 864
Score = 77.4 bits (189), Expect = 4e-14
Identities = 33/84 (39%), Positives = 44/84 (52%)
Query: 357 CLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFRCLCLPSY 416
C +GGTC Y C C G+ G CEL+ DEC S+PC +G C D + F C C +
Sbjct: 469 CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGF 528
Query: 417 VGALCEQDTETCDYGWHKFQGQCY 440
G LCE D + C+ + +CY
Sbjct: 529 SGPLCEVDVDLCEPSPCRNGARCY 552
Score = 75.9 bits (185), Expect = 1e-13
Identities = 32/86 (37%), Positives = 44/86 (51%), Gaps = 1/86 (1%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDE-CHSNPCRNGATCVD 403
C R +C C NGGTCY + ++ C C PG+ G C + + C NPC NG TCV
Sbjct: 709 CHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVG 768
Query: 404 GFNTFRCLCLPSYVGALCEQDTETCD 429
+F C+C + G C +T C+
Sbjct: 769 SGASFSCICRDGWEGRTCTHNTNDCN 794
Score = 75.1 bits (183), Expect = 2e-13
Identities = 57/193 (29%), Positives = 78/193 (40%), Gaps = 18/193 (9%)
Query: 245 VDHLDGDVFHLTVPSKF---TFEEAAKECENQDARLA-TVGELQAAWRNGFDQCDYGWLS 300
VD +DG F P ++ T + A ECE + A + L + + C GW
Sbjct: 401 VDQVDG--FECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGY---YCDCIPGW-K 454
Query: 301 DASVRHPVTVARAQC--GGGLLGVRTLYRFENQTGFPPPDSRFDAYCFKRPDRCKMNPCL 358
+ V R QC GG + Y+ GF +C D C +PC
Sbjct: 455 GINCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFG------GRHCELERDECASSPCH 508
Query: 359 NGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFRCLCLPSYVG 418
+GG C + C C G+SG CE+D D C +PCRNGA C + + C C + G
Sbjct: 509 SGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGG 568
Query: 419 ALCEQDTETCDYG 431
C E C G
Sbjct: 569 KNCSVPREPCPGG 581
Score = 72.8 bits (177), Expect = 9e-13
Identities = 35/104 (33%), Positives = 47/104 (45%), Gaps = 1/104 (0%)
Query: 338 DSRFDA-YCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCR 396
DS F YC + D C PC NGGTC ++ C C G+ G+ C+ + ++C +PC
Sbjct: 625 DSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCH 684
Query: 397 NGATCVDGFNTFRCLCLPSYVGALCEQDTETCDYGWHKFQGQCY 440
+ C D N F C C + G C CD G CY
Sbjct: 685 SRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCY 728
Score = 70.1 bits (170), Expect = 6e-12
Identities = 28/77 (36%), Positives = 38/77 (49%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDG 404
C P+ C +PC + G CY + C C G+ G C +C + C NG TC D
Sbjct: 671 CDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDS 730
Query: 405 FNTFRCLCLPSYVGALC 421
+TFRC C P + G+ C
Sbjct: 731 GDTFRCACPPGWKGSTC 747
Score = 68.9 bits (167), Expect = 1e-11
Identities = 30/90 (33%), Positives = 41/90 (45%), Gaps = 7/90 (7%)
Query: 350 DRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFR 409
D C NPC GGTC + C C + G C+LD +EC PC N +C + +
Sbjct: 387 DECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYY 446
Query: 410 CLCLPSYVGALCEQDTETCDYGWHKFQGQC 439
C C+P + G C + C +GQC
Sbjct: 447 CDCIPGWKGINCHINVNDC-------RGQC 469
Score = 67.8 bits (164), Expect = 3e-11
Identities = 40/132 (30%), Positives = 57/132 (43%), Gaps = 13/132 (9%)
Query: 309 TVARAQCGGGLLGVRTLYRFENQTGFPPPDSRFDAYCFKRPDRCKMNPCLNGGTCYPTET 368
+V R C GG R + + G P + C RC P GG
Sbjct: 572 SVPREPCPGG--ACRVIDGCGSDAGPGMPGTAASGVCGPH-GRCVSQP---GG------- 618
Query: 369 SYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFRCLCLPSYVGALCEQDTETC 428
++ C C G++G C + D+C PCRNG TC+D + FRC C + G LC+ + C
Sbjct: 619 NFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDC 678
Query: 429 DYGWHKFQGQCY 440
+G+CY
Sbjct: 679 LPDPCHSRGRCY 690
Score = 51.2 bits (121), Expect = 3e-06
Identities = 29/95 (30%), Positives = 43/95 (45%), Gaps = 7/95 (7%)
Query: 350 DRCKMNP-CLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHS-NPCRNGATCVDGF-N 406
D C P C++G P + C C + G C+ D + C S +PC NG TC++ +
Sbjct: 274 DECVPYPGCVHGSCVEPWQ----CNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPD 329
Query: 407 TFRCLCLPSYVGALCEQDTETCDYGWHKFQGQCYK 441
+RC C Y G CE+ C G C++
Sbjct: 330 QYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHE 364
Score = 50.8 bits (120), Expect = 4e-06
Identities = 24/103 (23%), Positives = 35/103 (33%), Gaps = 24/103 (23%)
Query: 350 DRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCR------------- 396
D C+ +PC NG CY E Y C C + G C + + C CR
Sbjct: 538 DLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGM 597
Query: 397 -----------NGATCVDGFNTFRCLCLPSYVGALCEQDTETC 428
+G F C+C + G C ++ + C
Sbjct: 598 PGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDC 640
Score = 35.8 bits (81), Expect = 0.13
Identities = 23/71 (32%), Positives = 33/71 (46%), Gaps = 11/71 (15%)
Query: 358 LNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFRCLCLPSYV 417
L+GG P E C C G+ G C DEC P +CV+ ++C C ++
Sbjct: 252 LHGGCTVPGE----CRCSYGWQGRFC----DECVPYPGCVHGSCVE---PWQCNCETNWG 300
Query: 418 GALCEQDTETC 428
G LC++D C
Sbjct: 301 GLLCDKDLNYC 311
>gi|134244285 Notch homolog 3 [Homo sapiens]
Length = 2321
Score = 98.6 bits (244), Expect = 2e-20
Identities = 40/95 (42%), Positives = 56/95 (58%)
Query: 337 PDSRFDAYCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCR 396
P+ R ++C + D C PC +GGTC Y+C C+PGY+GD CE D DEC S PC+
Sbjct: 1073 PEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQ 1132
Query: 397 NGATCVDGFNTFRCLCLPSYVGALCEQDTETCDYG 431
+G +C+D + C C P +G LCE + + C G
Sbjct: 1133 HGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPG 1167
Score = 97.1 bits (240), Expect = 5e-20
Identities = 38/85 (44%), Positives = 51/85 (60%)
Query: 344 YCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVD 403
YC D C+ +PC+NGG C + CTC G+SG C+LD DEC S PCRNGA CVD
Sbjct: 465 YCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVD 524
Query: 404 GFNTFRCLCLPSYVGALCEQDTETC 428
+ + C C + G LC+++ + C
Sbjct: 525 QPDGYECRCAEGFEGTLCDRNVDDC 549
Score = 96.3 bits (238), Expect = 8e-20
Identities = 40/84 (47%), Positives = 48/84 (57%), Gaps = 1/84 (1%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDG 404
C + D C NPC GTC S+ CTC PGY G CE D +C + C NG TCVDG
Sbjct: 884 CARDVDECLSNPC-GPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDG 942
Query: 405 FNTFRCLCLPSYVGALCEQDTETC 428
N+F CLC P Y GA C+ + + C
Sbjct: 943 VNSFSCLCRPGYTGAHCQHEADPC 966
Score = 94.7 bits (234), Expect = 2e-19
Identities = 42/114 (36%), Positives = 59/114 (51%), Gaps = 7/114 (6%)
Query: 316 GGGLLGVRTLYRFENQTGFPPPDSRFDAYCFKRPDRCKMNPCLNGGTCYPT-ETSYVCTC 374
GG L +R + G+ P C C +PC NGGTC + + +Y C C
Sbjct: 171 GGTCLNTPGSFRCQCPAGYTGP------LCENPAVPCAPSPCRNGGTCRQSGDLTYDCAC 224
Query: 375 VPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFRCLCLPSYVGALCEQDTETC 428
+PG+ G CE++ D+C + C NG TCVDG NT+ C C P + G C +D + C
Sbjct: 225 LPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDEC 278
Score = 90.5 bits (223), Expect = 4e-18
Identities = 40/84 (47%), Positives = 50/84 (59%), Gaps = 1/84 (1%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDG 404
C + + C NPCLNGG+C S+ C+C+PG++G +C D DEC SNPC G TC D
Sbjct: 846 CDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPG-TCTDH 904
Query: 405 FNTFRCLCLPSYVGALCEQDTETC 428
+F C C P Y G CEQD C
Sbjct: 905 VASFTCTCPPGYGGFHCEQDLPDC 928
Score = 89.4 bits (220), Expect = 1e-17
Identities = 37/86 (43%), Positives = 51/86 (59%), Gaps = 2/86 (2%)
Query: 345 CFKRPDRCKM--NPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCV 402
C + D C + NPC + G C T+ S++C C GY+G +CE D +EC S PCRN ATC+
Sbjct: 388 CDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCL 447
Query: 403 DGFNTFRCLCLPSYVGALCEQDTETC 428
D F C+C+ + G CE D + C
Sbjct: 448 DRIGQFTCICMAGFTGTYCEVDIDEC 473
Score = 82.8 bits (203), Expect = 9e-16
Identities = 33/84 (39%), Positives = 45/84 (53%), Gaps = 1/84 (1%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDG 404
C + D C+ PC +GG C Y+C C G +G CE++ D+C SNPC G C DG
Sbjct: 579 CESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFG-VCRDG 637
Query: 405 FNTFRCLCLPSYVGALCEQDTETC 428
N + C+C P + G LC + C
Sbjct: 638 INRYDCVCQPGFTGPLCNVEINEC 661
Score = 82.0 bits (201), Expect = 2e-15
Identities = 32/84 (38%), Positives = 43/84 (51%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDG 404
C + C PC N TC + C C+ G++G CE+D DEC S+PC NG C D
Sbjct: 428 CETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDR 487
Query: 405 FNTFRCLCLPSYVGALCEQDTETC 428
N F C C + G+ C+ D + C
Sbjct: 488 VNGFSCTCPSGFSGSTCQLDVDEC 511
Score = 81.3 bits (199), Expect = 3e-15
Identities = 33/90 (36%), Positives = 43/90 (47%), Gaps = 1/90 (1%)
Query: 350 DRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFR 409
D C PC NG C Y C C G+ G C+ + D+C +PC +G CVDG +F
Sbjct: 509 DECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHG-RCVDGIASFS 567
Query: 410 CLCLPSYVGALCEQDTETCDYGWHKFQGQC 439
C C P Y G CE + C + G+C
Sbjct: 568 CACAPGYTGTRCESQVDECRSQPCRHGGKC 597
Score = 80.9 bits (198), Expect = 3e-15
Identities = 44/142 (30%), Positives = 60/142 (42%), Gaps = 14/142 (9%)
Query: 294 CDYGWLSD-ASVRHPV----TVARAQCGGGLLGVRTLYRFENQTGFPPPDSRFDAYCFKR 348
C GW+ + + P R C ++ + GF PD
Sbjct: 67 CPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSL------- 119
Query: 349 PDRCKMNPCLNGGTC-YPTETSYVCTCVPGYSGDQCELDFDECH-SNPCRNGATCVDGFN 406
PD C +PC +G C + ++C+C PGY G C D DEC PCR+G TC++
Sbjct: 120 PDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPG 179
Query: 407 TFRCLCLPSYVGALCEQDTETC 428
+FRC C Y G LCE C
Sbjct: 180 SFRCQCPAGYTGPLCENPAVPC 201
Score = 80.5 bits (197), Expect = 5e-15
Identities = 34/85 (40%), Positives = 45/85 (52%), Gaps = 1/85 (1%)
Query: 345 CFKRPDRCK-MNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVD 403
C + D C PC G C S+ CTC GY+G C+ D ++C NPC NG +C D
Sbjct: 807 CQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQD 866
Query: 404 GFNTFRCLCLPSYVGALCEQDTETC 428
G +F C CLP + G C +D + C
Sbjct: 867 GVGSFSCSCLPGFAGPRCARDVDEC 891
Score = 79.0 bits (193), Expect = 1e-14
Identities = 36/92 (39%), Positives = 45/92 (48%), Gaps = 1/92 (1%)
Query: 337 PDSRFDAYCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCR 396
P C D C NPC G C Y C C PG++G C ++ +EC S+PC
Sbjct: 609 PSGTTGVNCEVNIDDCASNPC-TFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCG 667
Query: 397 NGATCVDGFNTFRCLCLPSYVGALCEQDTETC 428
G +CVDG N FRCLC P + LC + C
Sbjct: 668 EGGSCVDGENGFRCLCPPGSLPPLCLPPSHPC 699
Score = 79.0 bits (193), Expect = 1e-14
Identities = 44/132 (33%), Positives = 54/132 (40%), Gaps = 13/132 (9%)
Query: 307 PVTVARAQCGGGLLGVRTLYRFENQTGFPPPDSRFDAYCFKRPDRCKMNPCLNGGTCYPT 366
P Q GG G Y E G+ + D D C PC +GG+C
Sbjct: 1087 PCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDV------DECASQPCQHGGSCIDL 1140
Query: 367 ETSYVCTCVPGYSGDQCELDFDECHSNP-------CRNGATCVDGFNTFRCLCLPSYVGA 419
Y+C+C PG G CE++ D+C P C + TCVD FRC C P Y G
Sbjct: 1141 VARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGL 1200
Query: 420 LCEQDTETCDYG 431
CE D C G
Sbjct: 1201 RCEADINECRSG 1212
Score = 77.4 bits (189), Expect = 4e-14
Identities = 36/97 (37%), Positives = 49/97 (50%), Gaps = 1/97 (1%)
Query: 349 PDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTF 408
PD C + C NGGTC S+ C C PGY+G C+ + D C S PC +G C F
Sbjct: 926 PD-CSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGF 984
Query: 409 RCLCLPSYVGALCEQDTETCDYGWHKFQGQCYKYFAH 445
RC CL S+ G C+ + C + G+C + A+
Sbjct: 985 RCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAY 1021
Score = 76.6 bits (187), Expect = 7e-14
Identities = 36/86 (41%), Positives = 46/86 (53%), Gaps = 2/86 (2%)
Query: 345 CFKRPDRCKMN-PCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATC-V 402
C D C++ PC +GGTC T S+ C C GY+G CE C +PCRNG TC
Sbjct: 155 CRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQ 214
Query: 403 DGFNTFRCLCLPSYVGALCEQDTETC 428
G T+ C CLP + G CE + + C
Sbjct: 215 SGDLTYDCACLPGFEGQNCEVNVDDC 240
Score = 76.6 bits (187), Expect = 7e-14
Identities = 32/84 (38%), Positives = 44/84 (52%), Gaps = 1/84 (1%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDG 404
C + D C +PC + G C S+ C C PGY+G +CE DEC S PCR+G C+D
Sbjct: 542 CDRNVDDCSPDPC-HHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDL 600
Query: 405 FNTFRCLCLPSYVGALCEQDTETC 428
+ + C C G CE + + C
Sbjct: 601 VDKYLCRCPSGTTGVNCEVNIDDC 624
Score = 74.3 bits (181), Expect = 3e-13
Identities = 32/83 (38%), Positives = 46/83 (55%), Gaps = 2/83 (2%)
Query: 344 YCFKRPDRCKMNP--CLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATC 401
+C + D C++ P C NGGTC+ T + C CV G++G+ C + D+C + C +GATC
Sbjct: 270 FCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATC 329
Query: 402 VDGFNTFRCLCLPSYVGALCEQD 424
D +F C C G LC D
Sbjct: 330 HDRVASFYCACPMGKTGLLCHLD 352
Score = 73.6 bits (179), Expect = 6e-13
Identities = 32/86 (37%), Positives = 43/86 (50%), Gaps = 2/86 (2%)
Query: 343 AYCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCV 402
A+C D C PCL+GG C + CTC+ ++G QC+ D C PC+NG CV
Sbjct: 957 AHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCV 1016
Query: 403 DGFNTFRCLCLPSYVGALCEQDTETC 428
CLC P + G LC+ + C
Sbjct: 1017 Q--TGAYCLCPPGWSGRLCDIRSLPC 1040
Score = 73.2 bits (178), Expect = 7e-13
Identities = 32/86 (37%), Positives = 42/86 (48%), Gaps = 2/86 (2%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNP--CRNGATCV 402
C D C + CLNGGTC +Y C C P ++G C D DEC P C NG TC
Sbjct: 233 CEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCF 292
Query: 403 DGFNTFRCLCLPSYVGALCEQDTETC 428
+ C+C+ + G C Q+ + C
Sbjct: 293 NTLGGHSCVCVNGWTGESCSQNIDDC 318
Score = 71.6 bits (174), Expect = 2e-12
Identities = 35/94 (37%), Positives = 44/94 (46%), Gaps = 4/94 (4%)
Query: 350 DRCKMNPCLNGGTC--YPTETSYVCTCVPGYSGDQCELDFDECH--SNPCRNGATCVDGF 405
D C NPC C P +CTC PG++G C+ D DEC +NPC + CV+
Sbjct: 353 DACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQ 412
Query: 406 NTFRCLCLPSYVGALCEQDTETCDYGWHKFQGQC 439
+F C C Y G CE D C G + Q C
Sbjct: 413 GSFLCQCGRGYTGPRCETDVNECLSGPCRNQATC 446
Score = 71.2 bits (173), Expect = 3e-12
Identities = 28/72 (38%), Positives = 38/72 (52%)
Query: 357 CLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFRCLCLPSY 416
C GG C ++S+ C C G +G CE + D C + PC++G TC + C CLP Y
Sbjct: 1055 CQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGY 1114
Query: 417 VGALCEQDTETC 428
G CE D + C
Sbjct: 1115 NGDNCEDDVDEC 1126
Score = 67.0 bits (162), Expect = 5e-11
Identities = 38/113 (33%), Positives = 48/113 (42%), Gaps = 10/113 (8%)
Query: 337 PDSRFDAYCFKRPDRCKMNP-------CLNGGTCYPTETSYVCTCVPGYSGDQCELDFDE 389
P C D C P CL+ GTC + CTC PGY+G +CE D +E
Sbjct: 1149 PPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINE 1208
Query: 390 CHSNPCRNGAT--CV-DGFNTFRCLCLPSYVGALCEQDTETCDYGWHKFQGQC 439
C S C T C+ D FRCLC + G C+ C+ + GQC
Sbjct: 1209 CRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQC 1261
Score = 66.6 bits (161), Expect = 7e-11
Identities = 31/80 (38%), Positives = 37/80 (46%), Gaps = 2/80 (2%)
Query: 350 DRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFR 409
D C+ PC GGTC + CTC PG G QCEL C NPC +G C
Sbjct: 736 DACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCEL-LSPCTPNPCEHGGRCESAPGQLP 794
Query: 410 -CLCLPSYVGALCEQDTETC 428
C C + G C+QD + C
Sbjct: 795 VCSCPQGWQGPRCQQDVDEC 814
Score = 64.3 bits (155), Expect = 3e-10
Identities = 30/80 (37%), Positives = 38/80 (47%), Gaps = 2/80 (2%)
Query: 352 CKMNPCLNGGTCYPTETSY-VCTCVPGYSGDQCELDFDECHSN-PCRNGATCVDGFNTFR 409
C NPC +GG C VC+C G+ G +C+ D DEC PC C + +F
Sbjct: 775 CTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFS 834
Query: 410 CLCLPSYVGALCEQDTETCD 429
C C Y G C+QD CD
Sbjct: 835 CTCHGGYTGPSCDQDINDCD 854
Score = 60.1 bits (144), Expect = 6e-09
Identities = 31/87 (35%), Positives = 39/87 (44%), Gaps = 6/87 (6%)
Query: 350 DRCKMNPCLNGGTCYPTETS----YVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGF 405
D C PC G C + + + C C G+ G C L D C S+PC +GA C G
Sbjct: 80 DPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLP-DPCLSSPCAHGARCSVGP 138
Query: 406 N-TFRCLCLPSYVGALCEQDTETCDYG 431
+ F C C P Y G C D + C G
Sbjct: 139 DGRFLCSCPPGYQGRSCRSDVDECRVG 165
Score = 59.3 bits (142), Expect = 1e-08
Identities = 30/94 (31%), Positives = 41/94 (43%), Gaps = 12/94 (12%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECH----------SNP 394
C D C PC NGG C +T C C PG+SG C++ C
Sbjct: 997 CQTLVDWCSRQPCQNGGRC--VQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQL 1054
Query: 395 CRNGATCVDGFNTFRCLCLPSYVGALCEQDTETC 428
C+ G CVD ++ C+C G+ CEQ+ + C
Sbjct: 1055 CQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPC 1088
Score = 57.8 bits (138), Expect = 3e-08
Identities = 31/93 (33%), Positives = 38/93 (40%), Gaps = 7/93 (7%)
Query: 331 QTGFPPPDSRFDAYCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDEC 390
Q GF P C + C +PC GG+C E + C C PG C C
Sbjct: 646 QPGFTGP------LCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPC 699
Query: 391 HSNPCRNGATCVDGFNTFRCLCLPSYVGALCEQ 423
PC +G C D FRC+C P + G C Q
Sbjct: 700 AHEPCSHG-ICYDAPGGFRCVCEPGWSGPRCSQ 731
Score = 53.9 bits (128), Expect = 5e-07
Identities = 27/72 (37%), Positives = 35/72 (48%), Gaps = 6/72 (8%)
Query: 355 NPCLNGGTCYPTET-SYVCTCVPGYSGDQCELDFDECHSNPCRNGATC----VDGFNTFR 409
+PC NGG C + C C PG+ G++C+L+ D CHS PC C V G F
Sbjct: 47 SPCANGGRCTQLPSREAACLCPPGWVGERCQLE-DPCHSGPCAGRGVCQSSVVAGTARFS 105
Query: 410 CLCLPSYVGALC 421
C C + G C
Sbjct: 106 CRCPRGFRGPDC 117
Score = 44.7 bits (104), Expect = 3e-04
Identities = 22/75 (29%), Positives = 29/75 (38%), Gaps = 5/75 (6%)
Query: 352 CKMNPCLNGGTCYPTE-----TSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFN 406
C+ PC +GG C P+ ++ C C + G +CE C C G C
Sbjct: 1250 CESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPR 1309
Query: 407 TFRCLCLPSYVGALC 421
RC C P G C
Sbjct: 1310 GPRCACPPGLSGPSC 1324
Score = 41.2 bits (95), Expect = 0.003
Identities = 25/88 (28%), Positives = 31/88 (35%), Gaps = 10/88 (11%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCE--------LDFDECHSNPCR 396
C + C+ C G C T C C PG SG C C + PC
Sbjct: 1286 CERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCL 1345
Query: 397 NGATCVDG--FNTFRCLCLPSYVGALCE 422
+G +C FRC C + G CE
Sbjct: 1346 HGGSCRPAPLAPFFRCACAQGWTGPRCE 1373
Score = 30.4 bits (67), Expect = 5.4
Identities = 21/65 (32%), Positives = 28/65 (43%), Gaps = 8/65 (12%)
Query: 376 PGYSGDQCELDFDECHSNPCRNGATCVD-GFNTFRCLCLPSYVGALCEQDTETCDYGWHK 434
PG + C LD +PC NG C CLC P +VG C+ + + C G
Sbjct: 36 PGAAAPPC-LD-----GSPCANGGRCTQLPSREAACLCPPGWVGERCQLE-DPCHSGPCA 88
Query: 435 FQGQC 439
+G C
Sbjct: 89 GRGVC 93
>gi|148833508 notch1 preproprotein [Homo sapiens]
Length = 2555
Score = 97.8 bits (242), Expect = 3e-20
Identities = 41/97 (42%), Positives = 58/97 (59%), Gaps = 2/97 (2%)
Query: 345 CFKRPDRCKM--NPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCV 402
C + D C + NPC + G C T S+ C C+ GY+G +CE+D +EC SNPC+N ATC+
Sbjct: 409 CSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCL 468
Query: 403 DGFNTFRCLCLPSYVGALCEQDTETCDYGWHKFQGQC 439
D F+C+C+P Y G CE +T+ C G+C
Sbjct: 469 DQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRC 505
Score = 97.4 bits (241), Expect = 4e-20
Identities = 36/78 (46%), Positives = 50/78 (64%), Gaps = 1/78 (1%)
Query: 352 CKMNPCLNGGTCYPT-ETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFRC 410
C +PC NGGTC PT + ++ C C+PG++G CE + D+C N C+NG CVDG NT+ C
Sbjct: 222 CSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNC 281
Query: 411 LCLPSYVGALCEQDTETC 428
C P + G C +D + C
Sbjct: 282 RCPPEWTGQYCTEDVDEC 299
Score = 95.9 bits (237), Expect = 1e-19
Identities = 37/86 (43%), Positives = 49/86 (56%)
Query: 344 YCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVD 403
+C D C +PCL+ G C + C C G++G C+ D DEC S PC+NGA C+D
Sbjct: 486 HCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNGAKCLD 545
Query: 404 GFNTFRCLCLPSYVGALCEQDTETCD 429
G NT+ C+C Y G CE D + CD
Sbjct: 546 GPNTYTCVCTEGYTGTHCEVDIDECD 571
Score = 95.9 bits (237), Expect = 1e-19
Identities = 37/79 (46%), Positives = 46/79 (58%)
Query: 350 DRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFR 409
+ C ++PC +G +C T Y C C GYSG CE D D+C NPC NG +C DG NT
Sbjct: 871 NECVLSPCRHGASCQNTHGGYRCHCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINTAF 930
Query: 410 CLCLPSYVGALCEQDTETC 428
C CLP + G CE+D C
Sbjct: 931 CDCLPGFRGTFCEEDINEC 949
Score = 94.4 bits (233), Expect = 3e-19
Identities = 55/176 (31%), Positives = 72/176 (40%), Gaps = 12/176 (6%)
Query: 264 EEAAKECENQDARLATVGELQAAWRNGFDQCDYGWLSDASVRHPVTVARAQCGGGLLGVR 323
E + C+N L +GE Q G++ +D P G L
Sbjct: 455 ECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLH-----NGRCLDKI 509
Query: 324 TLYRFENQTGFPPPDSRFDAYCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQC 383
++ E TGF ++D D C PC NG C +Y C C GY+G C
Sbjct: 510 NEFQCECPTGFTGHLCQYDV------DECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHC 563
Query: 384 ELDFDECHSNPCRNGATCVDGFNTFRCLCLPSYVGALCEQDTETCDYGWHKFQGQC 439
E+D DEC +PC G +C DG TF CLC P Y G CE + C + G C
Sbjct: 564 EVDIDECDPDPCHYG-SCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTC 618
Score = 94.4 bits (233), Expect = 3e-19
Identities = 37/86 (43%), Positives = 49/86 (56%)
Query: 344 YCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVD 403
+C + + C +PC NG C SY CTC G+SG CE + +C + C NG TCVD
Sbjct: 941 FCEEDINECASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVD 1000
Query: 404 GFNTFRCLCLPSYVGALCEQDTETCD 429
G N+F CLC P + G+ C+ D CD
Sbjct: 1001 GINSFTCLCPPGFTGSYCQHDVNECD 1026
Score = 94.0 bits (232), Expect = 4e-19
Identities = 40/95 (42%), Positives = 53/95 (55%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDG 404
C + C+ NPC+NGGTC + YVCTC G+SG C+ + +EC SNPC N TC+D
Sbjct: 750 CDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDD 809
Query: 405 FNTFRCLCLPSYVGALCEQDTETCDYGWHKFQGQC 439
++C CL Y GA CE C + G+C
Sbjct: 810 VAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGEC 844
Score = 90.5 bits (223), Expect = 4e-18
Identities = 37/98 (37%), Positives = 51/98 (52%)
Query: 344 YCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVD 403
+C C + C NGGTC S+ C C PG++G C+ D +EC S PC +G TC D
Sbjct: 979 HCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQD 1038
Query: 404 GFNTFRCLCLPSYVGALCEQDTETCDYGWHKFQGQCYK 441
G ++RC C Y G C+ CD K G+C++
Sbjct: 1039 GCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQ 1076
Score = 90.1 bits (222), Expect = 6e-18
Identities = 48/129 (37%), Positives = 63/129 (48%), Gaps = 7/129 (5%)
Query: 302 ASVRHPVTVAR-AQCGGGLLGVRTLYRFENQTGFPPPDSRFDAYCFKRPDRCKMNPCLNG 360
A+ R V VAR Q GG + + Q G+ +YC D C +PC NG
Sbjct: 1104 AAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYT------GSYCEDLVDECSPSPCQNG 1157
Query: 361 GTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFRCLCLPSYVGAL 420
TC Y C CV GY G C + DEC S+PC+NG TC+D NT++C C G
Sbjct: 1158 ATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVH 1217
Query: 421 CEQDTETCD 429
CE + + C+
Sbjct: 1218 CEINVDDCN 1226
Score = 85.9 bits (211), Expect = 1e-16
Identities = 40/109 (36%), Positives = 54/109 (49%), Gaps = 8/109 (7%)
Query: 322 VRTLYRFENQT--GFPPPDSRFDAYCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYS 379
+ TL FE Q G+ P D + C NPC N TC + C C+PGY
Sbjct: 430 INTLGSFECQCLQGYTGPRCEIDV------NECVSNPCQNDATCLDQIGEFQCICMPGYE 483
Query: 380 GDQCELDFDECHSNPCRNGATCVDGFNTFRCLCLPSYVGALCEQDTETC 428
G CE++ DEC S+PC + C+D N F+C C + G LC+ D + C
Sbjct: 484 GVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDEC 532
Score = 84.7 bits (208), Expect = 2e-16
Identities = 31/85 (36%), Positives = 51/85 (60%), Gaps = 1/85 (1%)
Query: 344 YCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVD 403
+C + C PC +GGTC + +Y+C C+ G +G CE++ D+C S+PC +G TC+D
Sbjct: 599 HCETNINECSSQPCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSPCDSG-TCLD 657
Query: 404 GFNTFRCLCLPSYVGALCEQDTETC 428
+ + C C P Y G++C + + C
Sbjct: 658 KIDGYECACEPGYTGSMCNINIDEC 682
Score = 84.0 bits (206), Expect = 4e-16
Identities = 34/84 (40%), Positives = 47/84 (55%), Gaps = 2/84 (2%)
Query: 347 KRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNP--CRNGATCVDG 404
++ D C NPC NGG C P E SY+C C P + G C D +EC P CR+G TC +
Sbjct: 139 QQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNE 198
Query: 405 FNTFRCLCLPSYVGALCEQDTETC 428
++RC+C ++ G CE+ C
Sbjct: 199 VGSYRCVCRATHTGPNCERPYVPC 222
Score = 83.6 bits (205), Expect = 5e-16
Identities = 34/80 (42%), Positives = 41/80 (51%), Gaps = 1/80 (1%)
Query: 350 DRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFR 409
D C +PC + GTC Y C C PGY+G C ++ DEC NPC NG TC DG N F
Sbjct: 643 DDCASSPC-DSGTCLDKIDGYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFT 701
Query: 410 CLCLPSYVGALCEQDTETCD 429
C C Y C + C+
Sbjct: 702 CRCPEGYHDPTCLSEVNECN 721
Score = 82.0 bits (201), Expect = 2e-15
Identities = 36/103 (34%), Positives = 51/103 (49%), Gaps = 1/103 (0%)
Query: 337 PDSRFDAYCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCR 396
P+ D C + C NPC++G C + Y C C PG+SG C+++ +EC SNPC
Sbjct: 705 PEGYHDPTCLSEVNECNSNPCVHGA-CRDSLNGYKCDCDPGWSGTNCDINNNECESNPCV 763
Query: 397 NGATCVDGFNTFRCLCLPSYVGALCEQDTETCDYGWHKFQGQC 439
NG TC D + + C C + G C+ + C QG C
Sbjct: 764 NGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTC 806
Score = 80.1 bits (196), Expect = 6e-15
Identities = 40/92 (43%), Positives = 48/92 (52%), Gaps = 4/92 (4%)
Query: 352 CKMNPCLNGGTC-YPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFRC 410
C NPC NGGTC T T Y C C PG+SG C+ D C SNPC NG C+ ++ C
Sbjct: 106 CLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQ-QADPCASNPCANGGQCLPFEASYIC 164
Query: 411 LCLPSYVGALCEQDTETCDY--GWHKFQGQCY 440
C PS+ G C QD C G + G C+
Sbjct: 165 HCPPSFHGPTCRQDVNECGQKPGLCRHGGTCH 196
Score = 79.3 bits (194), Expect = 1e-14
Identities = 35/92 (38%), Positives = 45/92 (48%), Gaps = 8/92 (8%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECH--------SNPCR 396
C + D C +PC NGGTC +Y C+C G G CE++ D+C+ S C
Sbjct: 1180 CSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCF 1239
Query: 397 NGATCVDGFNTFRCLCLPSYVGALCEQDTETC 428
N TCVD + C C P +VG CE D C
Sbjct: 1240 NNGTCVDQVGGYSCTCPPGFVGERCEGDVNEC 1271
Score = 78.6 bits (192), Expect = 2e-14
Identities = 33/79 (41%), Positives = 45/79 (56%), Gaps = 2/79 (2%)
Query: 352 CKMNPCLNGGTCYPTET--SYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFR 409
C +PC NGG C +E S+ C C G+ G CE+D +EC +PCR+GA+C + +R
Sbjct: 833 CAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGGYR 892
Query: 410 CLCLPSYVGALCEQDTETC 428
C C Y G CE D + C
Sbjct: 893 CHCQAGYSGRNCETDIDDC 911
Score = 78.2 bits (191), Expect = 2e-14
Identities = 33/85 (38%), Positives = 46/85 (54%), Gaps = 1/85 (1%)
Query: 344 YCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVD 403
+C D C +PC + G+C ++ C C PGY+G CE + +EC S PCR+G TC D
Sbjct: 562 HCEVDIDECDPDPC-HYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQD 620
Query: 404 GFNTFRCLCLPSYVGALCEQDTETC 428
N + C CL G CE + + C
Sbjct: 621 RDNAYLCFCLKGTTGPNCEINLDDC 645
Score = 77.0 bits (188), Expect = 5e-14
Identities = 32/87 (36%), Positives = 45/87 (51%)
Query: 343 AYCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCV 402
+YC + C PCL+GGTC SY CTC GY+G C+ C S+PC+NG C
Sbjct: 1016 SYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCW 1075
Query: 403 DGFNTFRCLCLPSYVGALCEQDTETCD 429
+RC C + G C+ + +C+
Sbjct: 1076 QTHTQYRCECPSGWTGLYCDVPSVSCE 1102
Score = 76.6 bits (187), Expect = 7e-14
Identities = 34/80 (42%), Positives = 45/80 (56%), Gaps = 2/80 (2%)
Query: 344 YCFKRPDRCKMNP--CLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATC 401
YC + D C++ P C NGGTC+ T Y C CV G++G+ C + D+C S C +GATC
Sbjct: 291 YCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATC 350
Query: 402 VDGFNTFRCLCLPSYVGALC 421
D +F C C G LC
Sbjct: 351 HDRVASFYCECPHGRTGLLC 370
Score = 75.1 bits (183), Expect = 2e-13
Identities = 49/151 (32%), Positives = 65/151 (43%), Gaps = 10/151 (6%)
Query: 293 QCDYGWLSDASVRHPVTVARAQC--GGGLLGVRTLYRFENQTGFPPPDSRFDAY-CFKRP 349
+C GW S S + A C GG L Y F P R D C ++P
Sbjct: 128 RCPPGW-SGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKP 186
Query: 350 DRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATC-VDGFNTF 408
C+ +GGTC+ SY C C ++G CE + C +PC+NG TC G T
Sbjct: 187 GLCR-----HGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTH 241
Query: 409 RCLCLPSYVGALCEQDTETCDYGWHKFQGQC 439
C CLP + G CE++ + C K G C
Sbjct: 242 ECACLPGFTGQNCEENIDDCPGNNCKNGGAC 272
Score = 75.1 bits (183), Expect = 2e-13
Identities = 32/80 (40%), Positives = 43/80 (53%), Gaps = 1/80 (1%)
Query: 350 DRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFR 409
D C NPC NGGTC + C C GY C + +EC+SNPC +GA C D N ++
Sbjct: 680 DECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNECNSNPCVHGA-CRDSLNGYK 738
Query: 410 CLCLPSYVGALCEQDTETCD 429
C C P + G C+ + C+
Sbjct: 739 CDCDPGWSGTNCDINNNECE 758
Score = 72.0 bits (175), Expect = 2e-12
Identities = 35/85 (41%), Positives = 40/85 (47%), Gaps = 2/85 (2%)
Query: 357 CLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPC--RNGATCVDGFNTFRCLCLP 414
C N GTC Y CTC PG+ G++CE D +EC SNPC R CV N F C C
Sbjct: 1238 CFNNGTCVDQVGGYSCTCPPGFVGERCEGDVNECLSNPCDARGTQNCVQRVNDFHCECRA 1297
Query: 415 SYVGALCEQDTETCDYGWHKFQGQC 439
+ G CE C K G C
Sbjct: 1298 GHTGRRCESVINGCKGKPCKNGGTC 1322
Score = 71.2 bits (173), Expect = 3e-12
Identities = 30/86 (34%), Positives = 43/86 (50%), Gaps = 2/86 (2%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECH--SNPCRNGATCV 402
C + D C N C NGG C +Y C C P ++G C D DEC N C+NG TC
Sbjct: 254 CEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCH 313
Query: 403 DGFNTFRCLCLPSYVGALCEQDTETC 428
+ + C+C+ + G C ++ + C
Sbjct: 314 NTHGGYNCVCVNGWTGEDCSENIDDC 339
Score = 68.9 bits (167), Expect = 1e-11
Identities = 30/87 (34%), Positives = 41/87 (47%), Gaps = 10/87 (11%)
Query: 352 CKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECH----------SNPCRNGATC 401
C +PC NGG C+ T T Y C C G++G C++ C + C++G C
Sbjct: 1063 CDSSPCKNGGKCWQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLC 1122
Query: 402 VDGFNTFRCLCLPSYVGALCEQDTETC 428
VD NT C C Y G+ CE + C
Sbjct: 1123 VDAGNTHHCRCQAGYTGSYCEDLVDEC 1149
Score = 68.2 bits (165), Expect = 2e-11
Identities = 36/102 (35%), Positives = 49/102 (48%), Gaps = 7/102 (6%)
Query: 349 PDRCKMNPCLNGGTCYPTE----TSYVCTCVPGYSGDQCELDFDE-CHSNPCRNGATC-V 402
P+ C PC N GTC+ + Y C+C G+SG C D C +NPCRNG TC +
Sbjct: 60 PNPCLSTPCKNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDL 119
Query: 403 DGFNTFRCLCLPSYVGALCEQDTETCDYGWHKFQGQCYKYFA 444
++C C P + G C+Q + C GQC + A
Sbjct: 120 LTLTEYKCRCPPGWSGKSCQQ-ADPCASNPCANGGQCLPFEA 160
Score = 68.2 bits (165), Expect = 2e-11
Identities = 31/74 (41%), Positives = 38/74 (51%), Gaps = 3/74 (4%)
Query: 352 CKMNPCLNGGTCYP---TETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTF 408
CK PC NGGTC T ++C C G+ G CE D C S C NG TC+ G +
Sbjct: 1311 CKGKPCKNGGTCAVASNTARGFICKCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSP 1370
Query: 409 RCLCLPSYVGALCE 422
CLCL + G C+
Sbjct: 1371 TCLCLGPFTGPECQ 1384
Score = 66.6 bits (161), Expect = 7e-11
Identities = 32/84 (38%), Positives = 40/84 (47%), Gaps = 5/84 (5%)
Query: 350 DRCKMNPCLNGGT--CYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNT 407
+ C NPC GT C + C C G++G +CE + C PC+NG TC NT
Sbjct: 1269 NECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNGGTCAVASNT 1328
Query: 408 ---FRCLCLPSYVGALCEQDTETC 428
F C C + GA CE D TC
Sbjct: 1329 ARGFICKCPAGFEGATCENDARTC 1352
Score = 64.7 bits (156), Expect = 3e-10
Identities = 33/91 (36%), Positives = 42/91 (46%), Gaps = 7/91 (7%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATC--- 401
C + D C C +G TC+ S+ C C G +G C L+ D C SNPC G+ C
Sbjct: 332 CSENIDDCASAACFHGATCHDRVASFYCECPHGRTGLLCHLN-DACISNPCNEGSNCDTN 390
Query: 402 -VDGFNTFRCLCLPSYVGALCEQDTETCDYG 431
V+G C C Y G C QD + C G
Sbjct: 391 PVNG--KAICTCPSGYTGPACSQDVDECSLG 419
Score = 52.0 bits (123), Expect = 2e-06
Identities = 29/80 (36%), Positives = 37/80 (46%), Gaps = 7/80 (8%)
Query: 348 RPDRCKM--NPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATC--VD 403
R RC CLNGG C + C C + G +C+ D + C S PC+N TC VD
Sbjct: 20 RGPRCSQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQ-DPNPCLSTPCKNAGTCHVVD 78
Query: 404 --GFNTFRCLCLPSYVGALC 421
G + C C + G LC
Sbjct: 79 RRGVADYACSCALGFSGPLC 98
Score = 52.0 bits (123), Expect = 2e-06
Identities = 28/83 (33%), Positives = 36/83 (43%), Gaps = 4/83 (4%)
Query: 343 AYCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDE--CHSNPCRNGAT 400
A C C CLNGGTC S C C+ ++G +C+ NPC N T
Sbjct: 1343 ATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGPFTGPECQFPASSPCLGGNPCYNQGT 1402
Query: 401 CVDGFNT--FRCLCLPSYVGALC 421
C + +RCLC + G LC
Sbjct: 1403 CEPTSESPFYRCLCPAKFNGLLC 1425
>gi|148886654 polydom [Homo sapiens]
Length = 3571
Score = 96.7 bits (239), Expect = 6e-20
Identities = 39/83 (46%), Positives = 48/83 (57%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDG 404
C K D C PC NG TC S+ C C G++G CEL+ +EC SNPCRN ATCVD
Sbjct: 1342 CGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDE 1401
Query: 405 FNTFRCLCLPSYVGALCEQDTET 427
N++ C C P + G CE + T
Sbjct: 1402 LNSYSCKCQPGFSGKRCETEQST 1424
Score = 95.9 bits (237), Expect = 1e-19
Identities = 39/96 (40%), Positives = 53/96 (55%)
Query: 344 YCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVD 403
+C + C+ NPCLN C ++C C PG+ G +C + DEC S PC+NGATC D
Sbjct: 1303 HCETEVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKD 1362
Query: 404 GFNTFRCLCLPSYVGALCEQDTETCDYGWHKFQGQC 439
G N+FRCLC + G+ CE + C + Q C
Sbjct: 1363 GANSFRCLCAAGFTGSHCELNINECQSNPCRNQATC 1398
Score = 85.1 bits (209), Expect = 2e-16
Identities = 33/79 (41%), Positives = 44/79 (55%)
Query: 350 DRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFR 409
D C PCLN G C ++C C GY+G +CE + +EC S+PC N CVDG +R
Sbjct: 1233 DECSPLPCLNNGVCKDLVGEFICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYR 1292
Query: 410 CLCLPSYVGALCEQDTETC 428
C C+ +VG CE + C
Sbjct: 1293 CTCVKGFVGLHCETEVNEC 1311
Score = 84.3 bits (207), Expect = 3e-16
Identities = 34/84 (40%), Positives = 45/84 (53%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDG 404
C + + C +PCLN G C Y CTCV G+ G CE + +EC SNPC N A C D
Sbjct: 1266 CEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQ 1325
Query: 405 FNTFRCLCLPSYVGALCEQDTETC 428
F C C P ++G C ++ + C
Sbjct: 1326 VGGFLCKCPPGFLGTRCGKNVDEC 1349
Score = 79.3 bits (194), Expect = 1e-14
Identities = 34/77 (44%), Positives = 38/77 (49%)
Query: 352 CKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFRCL 411
C NPC N GTC YVC C GY+G +CE D DEC PC N C D F C
Sbjct: 1197 CFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICE 1256
Query: 412 CLPSYVGALCEQDTETC 428
C Y G CE++ C
Sbjct: 1257 CPSGYTGQRCEENINEC 1273
Score = 54.3 bits (129), Expect = 3e-07
Identities = 30/72 (41%), Positives = 35/72 (48%), Gaps = 9/72 (12%)
Query: 356 PCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFRCLCLPS 415
PCLNGG C Y C C PG++G +C C S PC NG CV RC CL S
Sbjct: 3507 PCLNGGRCV---APYQCDCPPGWTGSRCHTAV--CQS-PCLNGGKCV---RPNRCHCLSS 3557
Query: 416 YVGALCEQDTET 427
+ G C + T
Sbjct: 3558 WTGHNCSRKRRT 3569
Score = 48.1 bits (113), Expect = 2e-05
Identities = 23/81 (28%), Positives = 39/81 (48%), Gaps = 11/81 (13%)
Query: 532 NGQWNDVPCNYHLTYTCKKGTVACGQPPVVENAKTFGKMKPRYEINSLIRYHCKDGFIQR 591
+G W+ P HL + CG+PP +++A G + + + Y CK+G+
Sbjct: 1948 SGIWDRAPPACHLVF--------CGEPPAIKDAVITGN---NFTFRNTVTYTCKEGYTLA 1996
Query: 592 HLPTIRCLGNGRWAIPKITCM 612
L TI CL +G+W+ C+
Sbjct: 1997 GLDTIECLADGKWSRSDQQCL 2017
Score = 47.4 bits (111), Expect = 4e-05
Identities = 18/44 (40%), Positives = 25/44 (56%)
Query: 343 AYCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELD 386
++C + C+ NPC N TC SY C C PG+SG +CE +
Sbjct: 1378 SHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETE 1421
Score = 43.9 bits (102), Expect = 5e-04
Identities = 23/79 (29%), Positives = 32/79 (40%), Gaps = 9/79 (11%)
Query: 533 GQWNDVPCNYHLTYTCKKGTVACGQPPVVENAKTFGKMKPRYEINSLIRYHCKDGFIQRH 592
GQWN P + V CG+PP + N G Y +++ Y C GF +
Sbjct: 2130 GQWNPSPMSIQCI------PVRCGEPPSIMNGYASGS---NYSFGAMVAYSCNKGFYIKG 2180
Query: 593 LPTIRCLGNGRWAIPKITC 611
C G+W+ P TC
Sbjct: 2181 EKKSTCEATGQWSSPIPTC 2199
Score = 43.5 bits (101), Expect = 6e-04
Identities = 18/42 (42%), Positives = 20/42 (47%)
Query: 387 FDECHSNPCRNGATCVDGFNTFRCLCLPSYVGALCEQDTETC 428
F EC NPC N TC + CLC Y G CE D + C
Sbjct: 1194 FHECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDEC 1235
Score = 42.0 bits (97), Expect = 0.002
Identities = 30/94 (31%), Positives = 39/94 (41%), Gaps = 17/94 (18%)
Query: 538 VPCNYHLTYT-----CKKGTVACGQPPVVENAKTFGKMKPRYEINSLIRYHCKDGFIQRH 592
+ CN T+T C+K ++CG P VENA G Y+ +I Y C G++
Sbjct: 3396 ITCNPDETWTQTSAKCEK--ISCGPPAHVENAIARGV---HYQYGDMITYSCYSGYMLEG 3450
Query: 593 LPTIRCLGNGRWAIPKI-------TCMNPSAYQR 619
CL NG W P I C N QR
Sbjct: 3451 FLRSVCLENGTWTSPPICRAVCRFPCQNGGICQR 3484
Score = 37.4 bits (85), Expect = 0.044
Identities = 27/87 (31%), Positives = 35/87 (40%), Gaps = 23/87 (26%)
Query: 531 ENGQWNDVPCNYHLTYTCKKGTVACGQPPVVEN------AKTFGKMKPRYEINSLIRYHC 584
E+G+WN HL CK V+CG+P + EN A TFG S + Y C
Sbjct: 1831 ESGEWN------HLIPYCK--AVSCGKPAIPENGCIEELAFTFG---------SKVTYRC 1873
Query: 585 KDGFIQRHLPTIRCLGNGRWAIPKITC 611
G+ CL N W+ C
Sbjct: 1874 NKGYTLAGDKESSCLANSSWSHSPPVC 1900
Score = 37.0 bits (84), Expect = 0.057
Identities = 65/284 (22%), Positives = 91/284 (32%), Gaps = 66/284 (23%)
Query: 364 YPTETSYVCTCVPGYS--GDQ---CELD------FDECHSNPCRNGATCVDGFNTFRCLC 412
Y T SY TC PGY G+ C+ D C S C +GF F
Sbjct: 2677 YGTMVSY--TCNPGYELLGNPVLICQEDGTWNGSAPSCISIECDLPTAPENGFLRFTETS 2734
Query: 413 LPSYVGALCEQDTETCDYGWHKFQGQCYKYFAHRRTWDAAERECRLQGAHLTSILSHEEQ 472
+ S V C+ H G + R W A C S
Sbjct: 2735 MGSAVQYSCKPG--------HILAGSDLRLCLENRKWSGASPRCEA-----ISCKKPNPV 2781
Query: 473 MFVNRVGHDYQWIGLNDKMFEHD----FRWTDGSTLQYE-NWRPNQPDSFFSAGEDCVVI 527
M + G +Y + L+ +E D T+ T Q + NW ++P DC
Sbjct: 2782 MNGSIKGSNYTY--LSTLYYECDPGYVLNGTERRTCQDDKNWDEDEP---ICIPVDCSSP 2836
Query: 528 IWHENGQ--WNDVPCNYHLTYTCKKG-------------------------TVACGQPPV 560
NGQ ++ + YTC +G V C PP
Sbjct: 2837 PVSANGQVRGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQ 2896
Query: 561 VENAKTFGKMKPRYEINSLIRYHCKDGFIQRHLPTIRCLGNGRW 604
+ N T G Y + +HC +G+I P + C +G W
Sbjct: 2897 LANGVTEGL---DYGFMKEVTFHCHEGYILHGAPKLTCQSDGNW 2937
Score = 36.6 bits (83), Expect = 0.075
Identities = 37/160 (23%), Positives = 61/160 (38%), Gaps = 49/160 (30%)
Query: 482 YQWIGLNDKMFEHDFRWTDGSTLQYENWR----PNQPDSFFSAGEDCVVIIWHENGQWND 537
++ +GL++ E D +W+ G E+ P P++F S W EN
Sbjct: 3036 FKLLGLSEITCEADGQWSSGFP-HCEHTSCGSLPMIPNAFISETSS-----WKENV---- 3085
Query: 538 VPCNYHLTYTCKKGTV-------------------------ACGQPPVVENAKTFGKMKP 572
+TY+C+ G V +CG PP V NA G+
Sbjct: 3086 ------ITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVANAVATGE--- 3136
Query: 573 RYEINSLIRYHCKDGF-IQRHLPTIRCLGNGRWAIPKITC 611
+ S ++ C +G+ + T C +GRW +I+C
Sbjct: 3137 AHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISC 3176
Score = 36.2 bits (82), Expect = 0.098
Identities = 18/53 (33%), Positives = 23/53 (43%), Gaps = 3/53 (5%)
Query: 553 VACGQPPVVENAKTFGKMKPRYEINSLIRYHCKDGFIQRHLPTIRCLGNGRWA 605
V C PPV N + G Y I Y C +GF+ + CL NG W+
Sbjct: 2831 VDCSSPPVSANGQVRGD---EYTFQKEIEYTCNEGFLLEGARSRVCLANGSWS 2880
Score = 35.8 bits (81), Expect = 0.13
Identities = 25/76 (32%), Positives = 33/76 (43%), Gaps = 18/76 (23%)
Query: 533 GQWND-VPCNYHLTYTCKKGTVACGQPPVVENA---KTFGKMKPRYEINSLIRYHCKDGF 588
GQW+ +P TC V+CG+PP VEN T G++ S +RY C G+
Sbjct: 2190 GQWSSPIP-------TCHP--VSCGEPPKVENGFLEHTTGRI-----FESEVRYQCNPGY 2235
Query: 589 IQRHLPTIRCLGNGRW 604
P C N W
Sbjct: 2236 KSVGSPVFVCQANRHW 2251
Score = 35.0 bits (79), Expect = 0.22
Identities = 22/71 (30%), Positives = 33/71 (46%), Gaps = 9/71 (12%)
Query: 314 QCGGG--LLGVRTLYRFENQTGFPPPDSRFDAYCFKRPDRCKM-NPCLNGGTCYPTETSY 370
QC G LLG ++ +N + S D D C + + C +C + SY
Sbjct: 1715 QCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDV------DECAVGSDCSEHASCLNVDGSY 1768
Query: 371 VCTCVPGYSGD 381
+C+CVP Y+GD
Sbjct: 1769 ICSCVPPYTGD 1779
Score = 34.7 bits (78), Expect = 0.29
Identities = 25/81 (30%), Positives = 35/81 (43%), Gaps = 14/81 (17%)
Query: 534 QWNDVPCNYHLTYTCKKGTVACGQPPVVENAKTFGKMKPRYEIN--SLIRYHCKDGFIQR 591
QWND CK V C PP++ +FG P ++ S ++Y C GF R
Sbjct: 2368 QWNDS------FPVCK--IVLCTPPPLI----SFGVPIPSSALHFGSTVKYSCVGGFFLR 2415
Query: 592 HLPTIRCLGNGRWAIPKITCM 612
T C +G W+ P C+
Sbjct: 2416 GNSTTLCQPDGTWSSPLPECV 2436
Score = 34.3 bits (77), Expect = 0.37
Identities = 13/50 (26%), Positives = 24/50 (48%)
Query: 555 CGQPPVVENAKTFGKMKPRYEINSLIRYHCKDGFIQRHLPTIRCLGNGRW 604
C +PP V + K ++ S++ + C +GF+ I C+ G+W
Sbjct: 2083 CEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQW 2132
Score = 32.7 bits (73), Expect = 1.1
Identities = 21/92 (22%), Positives = 37/92 (40%), Gaps = 32/92 (34%)
Query: 544 LTYTCKKG-------------------------TVACGQPPVVENA--KTFGKMKPRYEI 576
+TYTCK+G V+C +PP+V++A +T ++
Sbjct: 1985 VTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRL-----F 2039
Query: 577 NSLIRYHCKDGFIQRHLPTIRCLGNGRWAIPK 608
+ Y+C DG+ + C G+W P+
Sbjct: 2040 GDIAFYYCSDGYSLADNSQLLCNAQGKWVPPE 2071
Score = 30.8 bits (68), Expect = 4.1
Identities = 13/35 (37%), Positives = 20/35 (57%), Gaps = 1/35 (2%)
Query: 385 LDFDECH-SNPCRNGATCVDGFNTFRCLCLPSYVG 418
LD DEC + C A+C++ ++ C C+P Y G
Sbjct: 1744 LDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTG 1778
Score = 30.4 bits (67), Expect = 5.4
Identities = 17/61 (27%), Positives = 27/61 (44%), Gaps = 3/61 (4%)
Query: 553 VACGQPPVVENAKTFGKMKPRYEINSLIRYHCKDGFIQRHLPTIRCLGNGRWAIPKITCM 612
++CG PP +EN F Y S + Y C +G+ + C NG W +C+
Sbjct: 1688 ISCGVPPPLENG--FHSADDFYA-GSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCL 1744
Query: 613 N 613
+
Sbjct: 1745 D 1745
Score = 30.4 bits (67), Expect = 5.4
Identities = 23/110 (20%), Positives = 45/110 (40%), Gaps = 20/110 (18%)
Query: 554 ACGQPPVVENAKTFGKMKPRYEINSLIRYHCKDGFIQRHLPTIRCLGNGRWAIP-----K 608
+CG P++ NA F ++ N +I Y C+ G++ + + C G W+ P
Sbjct: 3063 SCGSLPMIPNA--FISETSSWKEN-VITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEP 3119
Query: 609 ITCMNPSA------------YQRTYSMKYFKNSSSAKDNSINTSKHDHRW 646
++C +P + Y+ ++ + + D T + D RW
Sbjct: 3120 LSCGSPPSVANAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRW 3169
Score = 30.0 bits (66), Expect = 7.0
Identities = 13/52 (25%), Positives = 26/52 (50%), Gaps = 3/52 (5%)
Query: 553 VACGQPPVVENAKTFGKMKPRYEINSLIRYHCKDGFIQRHLPTIRCLGNGRW 604
+ C P EN + G++ Y + + + + C++G+ + I CL +G W
Sbjct: 1787 IKCKAPGNPENGHSSGEI---YTVGAEVTFSCQEGYQLMGVTKITCLESGEW 1835
Score = 29.6 bits (65), Expect = 9.2
Identities = 11/50 (22%), Positives = 26/50 (52%), Gaps = 3/50 (6%)
Query: 555 CGQPPVVENAKTFGKMKPRYEINSLIRYHCKDGFIQRHLPTIRCLGNGRW 604
C +PP++EN ++ + + + CK+G + + ++CL + +W
Sbjct: 2323 CPEPPLLENQLVLKELTTEVGV---VTFSCKEGHVLQGPSVLKCLPSQQW 2369
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 93.2 bits (230), Expect = 7e-19
Identities = 36/80 (45%), Positives = 48/80 (60%), Gaps = 3/80 (3%)
Query: 352 CKMNPCLNGGTCY---PTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTF 408
C NPC +GGTC+ E + C C G+ G+ CE++ D+C N C N +TCVDG N +
Sbjct: 961 CISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNY 1020
Query: 409 RCLCLPSYVGALCEQDTETC 428
CLC P Y G LCE+ + C
Sbjct: 1021 TCLCPPEYTGELCEEKLDFC 1040
Score = 86.3 bits (212), Expect = 8e-17
Identities = 37/95 (38%), Positives = 51/95 (53%), Gaps = 3/95 (3%)
Query: 330 NQTGFPPPDSRFDAYCFKRPDRCK--MNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDF 387
N T PP+ + C ++ D C +NPC + C T + C C PGY G+ C++DF
Sbjct: 1019 NYTCLCPPEYTGEL-CEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDF 1077
Query: 388 DECHSNPCRNGATCVDGFNTFRCLCLPSYVGALCE 422
D+C N C+NGA C D N + C+C Y G CE
Sbjct: 1078 DDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCE 1112
Score = 70.9 bits (172), Expect = 4e-12
Identities = 33/86 (38%), Positives = 44/86 (51%), Gaps = 2/86 (2%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCE--LDFDECHSNPCRNGATCV 402
C D C+ N C N TC +Y C C P Y+G+ CE LDF NPC++ + C+
Sbjct: 995 CEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCI 1054
Query: 403 DGFNTFRCLCLPSYVGALCEQDTETC 428
F+C C P YVG C+ D + C
Sbjct: 1055 LTPKGFKCDCTPGYVGEHCDIDFDDC 1080
Score = 51.6 bits (122), Expect = 2e-06
Identities = 31/112 (27%), Positives = 49/112 (43%), Gaps = 5/112 (4%)
Query: 350 DRCKMNPCLNGGTCYPTET-SYVCTCVPGYSGDQCELD---FDECHSNPCRNGATCVDGF 405
D C N C++G TC P SY C C+ G+ G C+ + F+ C + C++G + G
Sbjct: 1373 DPCLGNKCVHG-TCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGL 1431
Query: 406 NTFRCLCLPSYVGALCEQDTETCDYGWHKFQGQCYKYFAHRRTWDAAERECR 457
C C Y G C+++ + + Y A + T + ECR
Sbjct: 1432 GQPYCECSSGYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECR 1483
Score = 37.4 bits (85), Expect = 0.044
Identities = 14/37 (37%), Positives = 18/37 (48%)
Query: 348 RPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCE 384
R C C NG C +C C+PGY G++CE
Sbjct: 1121 RTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCE 1157
Score = 37.0 bits (84), Expect = 0.057
Identities = 18/52 (34%), Positives = 24/52 (46%), Gaps = 1/52 (1%)
Query: 390 CHSNPCRNGATC-VDGFNTFRCLCLPSYVGALCEQDTETCDYGWHKFQGQCY 440
C SNPC+N TC D + +RC C + G C+ C K G C+
Sbjct: 922 CLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCH 973
Score = 33.1 bits (74), Expect = 0.83
Identities = 21/87 (24%), Positives = 30/87 (34%), Gaps = 7/87 (8%)
Query: 388 DECHSNPCRNGATCVDGFNTFRCLCLPSYVGALCEQDTETCDYGWHKFQGQCYKYFAHRR 447
+ CH C +G F C C ++G LC+Q T G G C
Sbjct: 1334 EPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPI----- 1388
Query: 448 TWDAAERECRLQGAHLTSILSHEEQMF 474
+A C+ H + EE +F
Sbjct: 1389 --NAFSYSCKCLEGHGGVLCDEEEDLF 1413
>gi|9506545 delta-like 4 protein precursor [Homo sapiens]
Length = 685
Score = 92.8 bits (229), Expect = 9e-19
Identities = 39/75 (52%), Positives = 48/75 (64%), Gaps = 1/75 (1%)
Query: 355 NPCLNGGTCYPT-ETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFRCLCL 413
+PC NG TC + + SY CTC PGY+G CEL+ EC SNPCRNG +C D + + CLC
Sbjct: 292 SPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCP 351
Query: 414 PSYVGALCEQDTETC 428
P Y G CE T +C
Sbjct: 352 PGYYGLHCEHSTLSC 366
Score = 83.2 bits (204), Expect = 7e-16
Identities = 36/81 (44%), Positives = 43/81 (53%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDG 404
C K+ DRC NPC NGG C S +C C PG++G CEL +C NPC +G TC D
Sbjct: 399 CEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDL 458
Query: 405 FNTFRCLCLPSYVGALCEQDT 425
N C C + G CE T
Sbjct: 459 ENGLMCTCPAGFSGRRCEVRT 479
Score = 76.6 bits (187), Expect = 7e-14
Identities = 34/106 (32%), Positives = 46/106 (43%), Gaps = 2/106 (1%)
Query: 337 PDSRFDAYCFKRPDRCKMNPCLNGGTCYPTE--TSYVCTCVPGYSGDQCELDFDECHSNP 394
P + +C C +PC NGG+C +Y C C P ++G CE D C SNP
Sbjct: 351 PPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNP 410
Query: 395 CRNGATCVDGFNTFRCLCLPSYVGALCEQDTETCDYGWHKFQGQCY 440
C NG C++ + C C P + G CE C G C+
Sbjct: 411 CANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCH 456
Score = 76.6 bits (187), Expect = 7e-14
Identities = 36/83 (43%), Positives = 46/83 (55%), Gaps = 4/83 (4%)
Query: 344 YCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCEL--DFDECHSNPCRNGATC 401
YC C NPC +GGTC+ E +CTC G+SG +CE+ D C S+PC N ATC
Sbjct: 436 YCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATC 495
Query: 402 VDGF--NTFRCLCLPSYVGALCE 422
+TF C C +VG+ CE
Sbjct: 496 YTDLSTDTFVCNCPYGFVGSRCE 518
Score = 75.1 bits (183), Expect = 2e-13
Identities = 37/98 (37%), Positives = 47/98 (47%), Gaps = 4/98 (4%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVD- 403
C C NPC NGG+C E Y C C PGY G CE C +PC NG +C +
Sbjct: 321 CELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRER 380
Query: 404 --GFNTFRCLCLPSYVGALCEQDTETCDYGWHKFQGQC 439
G N + C C P++ G+ CE+ + C GQC
Sbjct: 381 NQGAN-YACECPPNFTGSNCEKKVDRCTSNPCANGGQC 417
Score = 65.9 bits (159), Expect = 1e-10
Identities = 39/114 (34%), Positives = 51/114 (44%), Gaps = 20/114 (17%)
Query: 342 DAYCFKRPDRCKMNPCLNG--------------GTCYPTETSYVCTCVPGYSGDQCELDF 387
+ YC K P C P G GTC T + CTC G+ G C+ D
Sbjct: 230 NGYCSK-PAECLCRPGWQGRLCNECIPHNGCRHGTC---STPWQCTCDEGWGGLFCDQDL 285
Query: 388 DEC-HSNPCRNGATCVD-GFNTFRCLCLPSYVGALCEQDTETCDYGWHKFQGQC 439
+ C H +PC+NGATC + G ++ C C P Y G CE + CD + G C
Sbjct: 286 NYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSC 339
Score = 34.7 bits (78), Expect = 0.29
Identities = 23/86 (26%), Positives = 34/86 (39%), Gaps = 30/86 (34%)
Query: 370 YVC------TCVPGYSGDQCELDFDECHSNPCRNGATCVDGF--NTFRCLCLPSYVGALC 421
YVC +C+PG++G+ C+ C +G +G+ CLC P + G LC
Sbjct: 198 YVCQPDGNLSCLPGWTGEYCQQPI-------CLSGCHEQNGYCSKPAECLCRPGWQGRLC 250
Query: 422 EQDTE---------------TCDYGW 432
+ TCD GW
Sbjct: 251 NECIPHNGCRHGTCSTPWQCTCDEGW 276
>gi|55770876 notch4 preproprotein [Homo sapiens]
Length = 2003
Score = 92.8 bits (229), Expect = 9e-19
Identities = 41/89 (46%), Positives = 52/89 (58%), Gaps = 5/89 (5%)
Query: 345 CFKRPDRCKM-----NPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGA 399
C + D C M +PC +GG+C T S+ C C PGY+G +CE D +EC S PC G+
Sbjct: 429 CHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNECLSQPCHPGS 488
Query: 400 TCVDGFNTFRCLCLPSYVGALCEQDTETC 428
TC+D TF CLC P G LCE +T C
Sbjct: 489 TCLDLLATFHCLCPPGLEGQLCEVETNEC 517
Score = 91.3 bits (225), Expect = 3e-18
Identities = 48/131 (36%), Positives = 58/131 (44%), Gaps = 8/131 (6%)
Query: 294 CDYGWLSDASVRHPVTVARAQC--GGGLLGVRTLYRFENQTGFPPPDSRFDAYCFKRPDR 351
CD GW A C GG + Y TG+ P C +
Sbjct: 679 CDVGWTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGYTGPT------CSEEMTA 732
Query: 352 CKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFRCL 411
C PCLNGG+C P+ Y CTC P ++G QC+ D C S PC NG TCV+ TF CL
Sbjct: 733 CHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCL 792
Query: 412 CLPSYVGALCE 422
C + G CE
Sbjct: 793 CAMGFQGPRCE 803
Score = 88.2 bits (217), Expect = 2e-17
Identities = 34/84 (40%), Positives = 45/84 (53%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDG 404
C + C PCLN C+ + C C+PG+SG +CE D DEC S+PC NG C D
Sbjct: 510 CEVETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQ 569
Query: 405 FNTFRCLCLPSYVGALCEQDTETC 428
F C CLP + G C+ + + C
Sbjct: 570 PGAFHCKCLPGFEGPRCQTEVDEC 593
Score = 87.8 bits (216), Expect = 3e-17
Identities = 34/84 (40%), Positives = 41/84 (48%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDG 404
C + C+ PC NG TC + Y+C C PGY G C + D C S PC N TC
Sbjct: 927 CQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPK 986
Query: 405 FNTFRCLCLPSYVGALCEQDTETC 428
F C C P +VG CE D + C
Sbjct: 987 PGGFHCACPPGFVGLRCEGDVDEC 1010
Score = 84.7 bits (208), Expect = 2e-16
Identities = 33/77 (42%), Positives = 42/77 (54%)
Query: 352 CKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFRCL 411
C PC +GGTCYP + Y CTC GY+G C + CHS PC NG +C + C
Sbjct: 695 CISAPCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCT 754
Query: 412 CLPSYVGALCEQDTETC 428
C PS+ G C+ T+ C
Sbjct: 755 CPPSHTGPQCQTSTDYC 771
Score = 83.6 bits (205), Expect = 5e-16
Identities = 37/95 (38%), Positives = 48/95 (50%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDG 404
C + C PC G TC ++ C C PG G CE++ +EC S PC N A C D
Sbjct: 472 CEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNECASAPCLNHADCHDL 531
Query: 405 FNTFRCLCLPSYVGALCEQDTETCDYGWHKFQGQC 439
N F+C+CLP + G CE+D + C GQC
Sbjct: 532 LNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQC 566
Score = 83.6 bits (205), Expect = 5e-16
Identities = 33/78 (42%), Positives = 47/78 (60%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDG 404
C + D C+ +PC NGG C ++ C C+PG+ G +C+ + DEC S+PC GA+C+D
Sbjct: 548 CEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQTEVDECLSDPCPVGASCLDL 607
Query: 405 FNTFRCLCLPSYVGALCE 422
F CLC + G LCE
Sbjct: 608 PGAFFCLCPSGFTGQLCE 625
Score = 82.0 bits (201), Expect = 2e-15
Identities = 35/89 (39%), Positives = 49/89 (55%), Gaps = 4/89 (4%)
Query: 345 CFKRPDRCKMNPCLNGGTCY----PTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGAT 400
C R C C NGGTC T ++C C PG+ G CE++ D C S+ C+NG T
Sbjct: 231 CELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDNCVSHQCQNGGT 290
Query: 401 CVDGFNTFRCLCLPSYVGALCEQDTETCD 429
C DG +T+ CLC ++ G C +D + C+
Sbjct: 291 CQDGLDTYTCLCPETWTGWDCSEDVDECE 319
Score = 80.1 bits (196), Expect = 6e-15
Identities = 36/86 (41%), Positives = 43/86 (50%), Gaps = 2/86 (2%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCR--NGATCV 402
C K D C+ PC N GTC P + C C PG+ G +CE D DEC PC A C
Sbjct: 965 CSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACH 1024
Query: 403 DGFNTFRCLCLPSYVGALCEQDTETC 428
N F C CLP + G CE + + C
Sbjct: 1025 SLANAFYCQCLPGHTGQWCEVEIDPC 1050
Score = 77.8 bits (190), Expect = 3e-14
Identities = 36/99 (36%), Positives = 49/99 (49%), Gaps = 9/99 (9%)
Query: 333 GFPPPDSRFDAYCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHS 392
GF PD C PD C + C NGGTC +Y C C ++G C D DEC +
Sbjct: 267 GFIGPD------CEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECET 320
Query: 393 N---PCRNGATCVDGFNTFRCLCLPSYVGALCEQDTETC 428
CRNG TC + +F C+C+ + G CE++ + C
Sbjct: 321 QGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDC 359
Score = 73.9 bits (180), Expect = 4e-13
Identities = 32/80 (40%), Positives = 43/80 (53%), Gaps = 3/80 (3%)
Query: 345 CFKRPDRCKMNP---CLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATC 401
C + D C+ C NGGTC + S+ C CV G+ G CE + D+C + C G+TC
Sbjct: 311 CSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTC 370
Query: 402 VDGFNTFRCLCLPSYVGALC 421
+D +F CLC P G LC
Sbjct: 371 IDRVGSFSCLCPPGRTGLLC 390
Score = 73.9 bits (180), Expect = 4e-13
Identities = 29/72 (40%), Positives = 40/72 (55%)
Query: 357 CLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFRCLCLPSY 416
C NGG C + SY C C PG+ G C+ + C S PC+NGATC+ + + C C P Y
Sbjct: 901 CHNGGLCVDSGPSYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGY 960
Query: 417 VGALCEQDTETC 428
G C ++ + C
Sbjct: 961 DGQNCSKELDAC 972
Score = 73.6 bits (179), Expect = 6e-13
Identities = 34/86 (39%), Positives = 42/86 (48%), Gaps = 7/86 (8%)
Query: 350 DRCKMNPCLNGGTCY--PTETSYVCTCVPGYSGDQCELDFDEC-----HSNPCRNGATCV 402
D C PC C P S +C C PGYSG C D DEC +PC +G +C+
Sbjct: 394 DMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCL 453
Query: 403 DGFNTFRCLCLPSYVGALCEQDTETC 428
+ +F CLC P Y G+ CE D C
Sbjct: 454 NTPGSFNCLCPPGYTGSRCEADHNEC 479
Score = 73.2 bits (178), Expect = 7e-13
Identities = 32/81 (39%), Positives = 40/81 (49%), Gaps = 2/81 (2%)
Query: 350 DRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSN--PCRNGATCVDGFNT 407
D C NPC+NGG C T C C PG+ G CE D +EC + PC G +C + +
Sbjct: 158 DFCSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCPKGTSCHNTLGS 217
Query: 408 FRCLCLPSYVGALCEQDTETC 428
F+CLC G CE C
Sbjct: 218 FQCLCPVGQEGPRCELRAGPC 238
Score = 67.0 bits (162), Expect = 5e-11
Identities = 30/83 (36%), Positives = 45/83 (54%), Gaps = 2/83 (2%)
Query: 347 KRPDRCKMNPCLNGGTCYPTETSYV-CTCVPGYSGDQCELDFDECHSNPCRNGATCVDGF 405
K D C + C G C+ + C+C+PG++G+QC+L D C +NPC NG C+ +
Sbjct: 117 KLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQCQLR-DFCSANPCVNGGVCLATY 175
Query: 406 NTFRCLCLPSYVGALCEQDTETC 428
+C C P + G CE+D C
Sbjct: 176 PQIQCHCPPGFEGHACERDVNEC 198
Score = 66.6 bits (161), Expect = 7e-11
Identities = 31/95 (32%), Positives = 44/95 (46%), Gaps = 5/95 (5%)
Query: 350 DRCKMNPCLNGGT--CYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNT 407
D C PC GT C+ ++ C C+PG++G CE++ D CHS PC +G TC +
Sbjct: 1008 DECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWCEVEIDPCHSQPCFHGGTCEATAGS 1067
Query: 408 ---FRCLCLPSYVGALCEQDTETCDYGWHKFQGQC 439
F C C + G C +C + G C
Sbjct: 1068 PLGFICHCPKGFEGPTCSHRAPSCGFHHCHHGGLC 1102
Score = 63.9 bits (154), Expect = 4e-10
Identities = 29/95 (30%), Positives = 40/95 (42%), Gaps = 10/95 (10%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECH----------SNP 394
C D C PC C T S+ C C+ G++G C L C S+
Sbjct: 841 CQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSL 900
Query: 395 CRNGATCVDGFNTFRCLCLPSYVGALCEQDTETCD 429
C NG CVD ++ C C P + G+LC+ C+
Sbjct: 901 CHNGGLCVDSGPSYFCHCPPGFQGSLCQDHVNPCE 935
Score = 63.2 bits (152), Expect = 7e-10
Identities = 26/77 (33%), Positives = 35/77 (45%)
Query: 352 CKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFRCL 411
C +PC N TC + C C GY+G C+ D C PC + C+ +F CL
Sbjct: 810 CADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCL 869
Query: 412 CLPSYVGALCEQDTETC 428
CL + G LC +C
Sbjct: 870 CLQGWTGPLCNLPLSSC 886
Score = 62.0 bits (149), Expect = 2e-09
Identities = 32/86 (37%), Positives = 38/86 (44%), Gaps = 3/86 (3%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDG 404
C + D C C G TC S+ C C PG +G C L+ D C S PC A C
Sbjct: 352 CEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLE-DMCLSQPCHGDAQCSTN 410
Query: 405 --FNTFRCLCLPSYVGALCEQDTETC 428
+ CLC P Y G C QD + C
Sbjct: 411 PLTGSTLCLCQPGYSGPTCHQDLDEC 436
Score = 53.9 bits (128), Expect = 5e-07
Identities = 33/116 (28%), Positives = 45/116 (38%), Gaps = 7/116 (6%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDG 404
C D C +PC G +C ++ C C G++G CE+ C N C+ C D
Sbjct: 586 CQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPL--CAPNLCQPKQICKDQ 643
Query: 405 FNTFRCLCLPSYVGALCEQDTETCDYGWHKFQGQCYKYFAHRRTWDAAERECRLQG 460
+ CLC G +D TC +G H + C W E E L G
Sbjct: 644 KDKANCLCPDGSPGCAPPEDNCTCHHG-HCQRSSCVCDVG----WTGPECEAELGG 694
Score = 53.9 bits (128), Expect = 5e-07
Identities = 29/85 (34%), Positives = 37/85 (43%), Gaps = 8/85 (9%)
Query: 344 YCFKRPDRCKMNPCLNGGTCYPTETS---YVCTCVPGYSGDQCELDFDECHSNPCRNGAT 400
+C D C PC +GGTC T S ++C C G+ G C C + C +G
Sbjct: 1042 WCEVEIDPCHSQPCFHGGTCEATAGSPLGFICHCPKGFEGPTCSHRAPSCGFHHCHHGGL 1101
Query: 401 CV----DGFNTFRCLCLPSYVGALC 421
C+ GF RC CL Y G C
Sbjct: 1102 CLPSPKPGFPP-RCACLSGYGGPDC 1125
Score = 53.5 bits (127), Expect = 6e-07
Identities = 22/68 (32%), Positives = 31/68 (45%)
Query: 372 CTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFRCLCLPSYVGALCEQDTETCDYG 431
C C G++G +CE + C S PC +G TC + + C C Y G C ++ C G
Sbjct: 677 CVCDVGWTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSG 736
Query: 432 WHKFQGQC 439
G C
Sbjct: 737 PCLNGGSC 744
Score = 51.6 bits (122), Expect = 2e-06
Identities = 30/102 (29%), Positives = 44/102 (43%), Gaps = 18/102 (17%)
Query: 356 PCLNGGTCYPTETSY-VCTCVPGYSGDQCELDFDEC-HSNPCRNGATCVDGF-------- 405
PC NGGTC C C PG+ G+ C+ D C ++ C+NG +C
Sbjct: 34 PCANGGTCLSLSLGQGTCQCAPGFLGETCQFP-DPCQNAQLCQNGGSCQALLPAPLGLPS 92
Query: 406 ------NTFRCLCLPSYVGALCEQDTE-TCDYGWHKFQGQCY 440
+F C CLP + G C+ E C + +G+C+
Sbjct: 93 SPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCH 134
>gi|4557679 jagged 1 precursor [Homo sapiens]
Length = 1218
Score = 92.0 bits (227), Expect = 2e-18
Identities = 78/282 (27%), Positives = 107/282 (37%), Gaps = 23/282 (8%)
Query: 344 YCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVD 403
YC + + C+ NPC NGGTC SY C C G+ G CE + ++C NPC NG TC D
Sbjct: 625 YCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRD 684
Query: 404 GFNTFRCLCLPSYVGALCEQDTETCDYGWHKFQGQCYKYFAHRRT-----WD------AA 452
N F C C + G C CD G CY + W+ A
Sbjct: 685 LVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIAR 744
Query: 453 ERECRLQGAHL--TSILSHEEQMFVNRVGHDYQWIGLNDKMFEHDFRWTDGSTLQYENWR 510
C H T +++ E V + G + N + G+ + +NW
Sbjct: 745 NSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWY 804
Query: 511 PNQPDSFFSAGEDCVVIIWHENGQWNDVPCNYHLTYTCKKGTVACGQPPVVENAKTFG-K 569
+ F AG DC + I + PC + T + C PP AK
Sbjct: 805 RCECAPGF-AGPDCRINI----NECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVS 859
Query: 570 MKPRYEINSLIRYHCKDGFIQRHLPTIRCLGNGRWAIPKITC 611
+P + S+I K T +CL NGR A K+ C
Sbjct: 860 GRPCITMGSVIPDGAK---WDDDCNTCQCL-NGRIACSKVWC 897
Score = 87.8 bits (216), Expect = 3e-17
Identities = 37/87 (42%), Positives = 47/87 (54%)
Query: 354 MNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFRCLCL 413
+ C N +C Y C C PGY+GD CE D DEC SNPC NG C + N F+CLC
Sbjct: 455 LGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCP 514
Query: 414 PSYVGALCEQDTETCDYGWHKFQGQCY 440
+ G LC+ D + C+ + QCY
Sbjct: 515 TGFSGNLCQLDIDYCEPNPCQNGAQCY 541
Score = 82.8 bits (203), Expect = 9e-16
Identities = 37/93 (39%), Positives = 48/93 (51%), Gaps = 1/93 (1%)
Query: 336 PPDSRFDAYCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPC 395
PP D +C + D C NPCLNGG C + C C G+SG+ C+LD D C NPC
Sbjct: 476 PPGYAGD-HCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPC 534
Query: 396 RNGATCVDGFNTFRCLCLPSYVGALCEQDTETC 428
+NGA C + + + C C Y G C + C
Sbjct: 535 QNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHC 567
Score = 81.3 bits (199), Expect = 3e-15
Identities = 30/78 (38%), Positives = 43/78 (55%)
Query: 352 CKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFRCL 411
C +PC N G+C T + C C PG++G C + D+C N C +G TC D N F+C+
Sbjct: 340 CLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCV 399
Query: 412 CLPSYVGALCEQDTETCD 429
C P + G C+ D C+
Sbjct: 400 CPPQWTGKTCQLDANECE 417
Score = 73.9 bits (180), Expect = 4e-13
Identities = 29/84 (34%), Positives = 44/84 (52%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDG 404
C D C N C +GGTC + C C P ++G C+LD +EC + PC N +C +
Sbjct: 371 CSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNL 430
Query: 405 FNTFRCLCLPSYVGALCEQDTETC 428
++ C CLP ++G C+ + C
Sbjct: 431 IASYYCDCLPGWMGQNCDININDC 454
Score = 73.9 bits (180), Expect = 4e-13
Identities = 29/75 (38%), Positives = 42/75 (56%), Gaps = 1/75 (1%)
Query: 355 NPCLNGGTCYPTETS-YVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFRCLCL 413
N C G C + C C G++G C + ++C SNPCRNG TC+DG N+++C+C
Sbjct: 597 NVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICS 656
Query: 414 PSYVGALCEQDTETC 428
+ GA CE + C
Sbjct: 657 DGWEGAYCETNINDC 671
Score = 72.8 bits (177), Expect = 9e-13
Identities = 47/151 (31%), Positives = 59/151 (39%), Gaps = 17/151 (11%)
Query: 293 QCDYGWLS---DASVRHPVTVARAQCGGGLLGVRTLYRFENQTGFPPPDSRFDAYCFKRP 349
+C YGW D + HP C G+ E G D + YC
Sbjct: 252 RCQYGWQGLYCDKCIPHP------GCVHGICNEPWQCLCETNWGGQLCDKDLN-YCGTH- 303
Query: 350 DRCKMNPCLNGGTCYPT-ETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTF 408
PCLNGGTC T Y C+C GYSG CE+ C S+PC N +C + F
Sbjct: 304 -----QPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGF 358
Query: 409 RCLCLPSYVGALCEQDTETCDYGWHKFQGQC 439
C C P + G C + + C G C
Sbjct: 359 ECECSPGWTGPTCSTNIDDCSPNNCSHGGTC 389
Score = 72.0 bits (175), Expect = 2e-12
Identities = 29/79 (36%), Positives = 37/79 (46%)
Query: 343 AYCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCV 402
AYC + C NPC NGGTC + C C G+ G C +C C NG TC
Sbjct: 662 AYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCY 721
Query: 403 DGFNTFRCLCLPSYVGALC 421
D + F+C+C + G C
Sbjct: 722 DEGDAFKCMCPGGWEGTTC 740
Score = 52.4 bits (124), Expect = 1e-06
Identities = 33/126 (26%), Positives = 46/126 (36%), Gaps = 5/126 (3%)
Query: 350 DRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFR 409
D C+ NPC NG CY + Y C C Y G C D C + PC +C +
Sbjct: 527 DYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASND 586
Query: 410 CLCLPSYVGA-LCEQDTETCDYGWHKFQGQCYKYF----AHRRTWDAAERECRLQGAHLT 464
Y+ + +C + KF C K F H D CR G +
Sbjct: 587 TPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCID 646
Query: 465 SILSHE 470
+ S++
Sbjct: 647 GVNSYK 652
>gi|33667103 C-type lectin, superfamily member 14 isoform 1 [Homo
sapiens]
Length = 316
Score = 92.0 bits (227), Expect = 2e-18
Identities = 48/131 (36%), Positives = 70/131 (53%), Gaps = 11/131 (8%)
Query: 428 CDYGWHKFQGQCYKYFAHRRTWDAAERECRLQGAHLTSILSHEEQMFVNR-VGHDYQWIG 486
C W + Q CY + +W AE+ C+L+ AHL I S EEQ FV + +G Y W+G
Sbjct: 181 CPVNWVEHQDSCYWFSHSGMSWAEAEKYCQLKNAHLVVINSREEQNFVQKYLGSAYTWMG 240
Query: 487 LNDKMFEHDFRWTDGS--TLQYENWRPNQPDSF----FSAGEDCVVIIWHENGQWNDVPC 540
L+D E ++W DG+ ++NW+P QPD + GEDC +H +G+WND C
Sbjct: 241 LSDP--EGAWKWVDGTDYATGFQNWKPGQPDDWQGHGLGGGEDCA--HFHPDGRWNDDVC 296
Query: 541 NYHLTYTCKKG 551
+ C+ G
Sbjct: 297 QRPYHWVCEAG 307
>gi|53832016 C-type lectin, superfamily member 14 isoform 2 [Homo
sapiens]
Length = 292
Score = 92.0 bits (227), Expect = 2e-18
Identities = 48/131 (36%), Positives = 70/131 (53%), Gaps = 11/131 (8%)
Query: 428 CDYGWHKFQGQCYKYFAHRRTWDAAERECRLQGAHLTSILSHEEQMFVNR-VGHDYQWIG 486
C W + Q CY + +W AE+ C+L+ AHL I S EEQ FV + +G Y W+G
Sbjct: 157 CPVNWVEHQDSCYWFSHSGMSWAEAEKYCQLKNAHLVVINSREEQNFVQKYLGSAYTWMG 216
Query: 487 LNDKMFEHDFRWTDGS--TLQYENWRPNQPDSF----FSAGEDCVVIIWHENGQWNDVPC 540
L+D E ++W DG+ ++NW+P QPD + GEDC +H +G+WND C
Sbjct: 217 LSDP--EGAWKWVDGTDYATGFQNWKPGQPDDWQGHGLGGGEDCA--HFHPDGRWNDDVC 272
Query: 541 NYHLTYTCKKG 551
+ C+ G
Sbjct: 273 QRPYHWVCEAG 283
>gi|110735443 delta-like 1 [Homo sapiens]
Length = 723
Score = 91.7 bits (226), Expect = 2e-18
Identities = 36/86 (41%), Positives = 47/86 (54%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDG 404
C K+ D C +PC NG C +Y+C C G+SG C+ + D+C S+PC NG TC DG
Sbjct: 402 CEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDG 461
Query: 405 FNTFRCLCLPSYVGALCEQDTETCDY 430
N F C C P Y G C C++
Sbjct: 462 VNDFSCTCPPGYTGRNCSAPVSRCEH 487
Score = 89.4 bits (220), Expect = 1e-17
Identities = 39/85 (45%), Positives = 50/85 (58%), Gaps = 1/85 (1%)
Query: 356 PCLNGGTCYPT-ETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFRCLCLP 414
PC NG TC T + SY C+C PGY+G CEL DEC +PC+NG +C D N++ C C P
Sbjct: 297 PCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPP 356
Query: 415 SYVGALCEQDTETCDYGWHKFQGQC 439
+ G +CE TC G G+C
Sbjct: 357 GFYGKICELSAMTCADGPCFNGGRC 381
Score = 75.9 bits (185), Expect = 1e-13
Identities = 36/101 (35%), Positives = 46/101 (45%), Gaps = 1/101 (0%)
Query: 329 ENQTGFPPPDSRFDAYCFKRPDRCKMNPCLNGGTCYPT-ETSYVCTCVPGYSGDQCELDF 387
EN P + C C PC NGG C + + Y C C GYSG CE
Sbjct: 347 ENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKI 406
Query: 388 DECHSNPCRNGATCVDGFNTFRCLCLPSYVGALCEQDTETC 428
D C S+PC NGA CVD + + C C + G C+ + + C
Sbjct: 407 DYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDC 447
Score = 75.9 bits (185), Expect = 1e-13
Identities = 31/79 (39%), Positives = 39/79 (49%)
Query: 344 YCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVD 403
+C D C +PC NGGTC + CTC PGY+G C C PC NGATC +
Sbjct: 439 HCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHE 498
Query: 404 GFNTFRCLCLPSYVGALCE 422
+ + C C Y G C+
Sbjct: 499 RGHRYVCECARGYGGPNCQ 517
Score = 75.1 bits (183), Expect = 2e-13
Identities = 36/87 (41%), Positives = 42/87 (48%), Gaps = 1/87 (1%)
Query: 343 AYCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCV 402
A C D C +PC NGG+C E SY CTC PG+ G CEL C PC NG C
Sbjct: 323 ATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCS 382
Query: 403 DG-FNTFRCLCLPSYVGALCEQDTETC 428
D + C C Y G CE+ + C
Sbjct: 383 DSPDGGYSCRCPVGYSGFNCEKKIDYC 409
Score = 67.4 bits (163), Expect = 4e-11
Identities = 37/98 (37%), Positives = 46/98 (46%), Gaps = 9/98 (9%)
Query: 344 YCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDEC-HSNPCRNGATCV 402
YC D C P GTC + + C C G+ G C D + C H PC+NGATC
Sbjct: 253 YC----DECIRYPGCLHGTC---QQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCT 305
Query: 403 D-GFNTFRCLCLPSYVGALCEQDTETCDYGWHKFQGQC 439
+ G ++ C C P Y GA CE + CD K G C
Sbjct: 306 NTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSC 343
Score = 45.1 bits (105), Expect = 2e-04
Identities = 19/50 (38%), Positives = 22/50 (44%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNP 394
C RC+ PC NG TC+ YVC C GY G C+ E P
Sbjct: 478 CSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGP 527
>gi|112420992 crumbs homolog 2 [Homo sapiens]
Length = 1285
Score = 91.7 bits (226), Expect = 2e-18
Identities = 43/114 (37%), Positives = 57/114 (50%), Gaps = 9/114 (7%)
Query: 336 PPDSRFDAYC---FKRP------DRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELD 386
P + F YC F+ P D C PC +G TC Y C C GY+G CE++
Sbjct: 87 PDPTGFRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEME 146
Query: 387 FDECHSNPCRNGATCVDGFNTFRCLCLPSYVGALCEQDTETCDYGWHKFQGQCY 440
DEC S PC +G +C+DG +FRC+C P Y G C+ D + C G C+
Sbjct: 147 VDECASAPCLHGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCH 200
Score = 90.5 bits (223), Expect = 4e-18
Identities = 38/91 (41%), Positives = 51/91 (56%), Gaps = 1/91 (1%)
Query: 350 DRCKMNPCLNGGTCYPTETSYVCTCV-PGYSGDQCELDFDECHSNPCRNGATCVDGFNTF 408
D C+ PC +GGTC+ + C C GY G CE + EC S PC + A+C++G +F
Sbjct: 186 DECQSQPCAHGGTCHDLVNGFRCDCAGTGYEGTHCEREVLECASAPCEHNASCLEGLGSF 245
Query: 409 RCLCLPSYVGALCEQDTETCDYGWHKFQGQC 439
RCLC P Y G LCE D + C + G+C
Sbjct: 246 RCLCWPGYSGELCEVDEDECASSPCQHGGRC 276
Score = 89.7 bits (221), Expect = 7e-18
Identities = 39/85 (45%), Positives = 47/85 (55%), Gaps = 1/85 (1%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDG 404
C D C PCL+GG+C S+ C C PGY G +C+LD DEC S PC +G TC D
Sbjct: 143 CEMEVDECASAPCLHGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDL 202
Query: 405 FNTFRCLCL-PSYVGALCEQDTETC 428
N FRC C Y G CE++ C
Sbjct: 203 VNGFRCDCAGTGYEGTHCEREVLEC 227
Score = 76.3 bits (186), Expect = 9e-14
Identities = 39/107 (36%), Positives = 48/107 (44%), Gaps = 6/107 (5%)
Query: 326 YRFENQTGF----PPPDSRFDAYCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGD 381
+ F + GF PP D C D C PCLNGG C + C C GY+G
Sbjct: 296 FSFRHAAGFLCHCPPGFEGAD--CGVEVDECASRPCLNGGHCQDLPNGFQCHCPDGYAGP 353
Query: 382 QCELDFDECHSNPCRNGATCVDGFNTFRCLCLPSYVGALCEQDTETC 428
CE D DEC S+PC +G TC D + C C ++ G C C
Sbjct: 354 TCEEDVDECLSDPCLHGGTCSDTVAGYICRCPETWGGRDCSVQLTGC 400
Score = 73.9 bits (180), Expect = 4e-13
Identities = 36/112 (32%), Positives = 46/112 (41%), Gaps = 32/112 (28%)
Query: 349 PDRCKMNPCLNGGTCYPTE--------------------------------TSYVCTCVP 376
P C +PC G C TE T + C CVP
Sbjct: 39 PSACASDPCAPGTECQATESGGYTCGPMEPRGCATQPCHHGALCVPQGPDPTGFRCYCVP 98
Query: 377 GYSGDQCELDFDECHSNPCRNGATCVDGFNTFRCLCLPSYVGALCEQDTETC 428
G+ G +CELD DEC S PC +GATC + + + C C Y G CE + + C
Sbjct: 99 GFQGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEVDEC 150
Score = 73.6 bits (179), Expect = 6e-13
Identities = 34/105 (32%), Positives = 45/105 (42%), Gaps = 21/105 (20%)
Query: 345 CFKRPDRCKMNPCLNGGTC---------------------YPTETSYVCTCVPGYSGDQC 383
C D C +PC +GG C + ++C C PG+ G C
Sbjct: 258 CEVDEDECASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADC 317
Query: 384 ELDFDECHSNPCRNGATCVDGFNTFRCLCLPSYVGALCEQDTETC 428
++ DEC S PC NG C D N F+C C Y G CE+D + C
Sbjct: 318 GVEVDECASRPCLNGGHCQDLPNGFQCHCPDGYAGPTCEEDVDEC 362
Score = 68.6 bits (166), Expect = 2e-11
Identities = 31/93 (33%), Positives = 43/93 (46%), Gaps = 4/93 (4%)
Query: 337 PDSRFDAYCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCR 396
PD C + D C +PCL+GGTC T Y+C C + G C + C + C
Sbjct: 347 PDGYAGPTCEEDVDECLSDPCLHGGTCSDTVAGYICRCPETWGGRDCSVQLTGCQGHTCP 406
Query: 397 NGATCV----DGFNTFRCLCLPSYVGALCEQDT 425
ATC+ G +++ C C P G C Q+T
Sbjct: 407 LAATCIPIFESGVHSYVCHCPPGTHGPFCGQNT 439
Score = 65.9 bits (159), Expect = 1e-10
Identities = 34/106 (32%), Positives = 49/106 (46%), Gaps = 21/106 (19%)
Query: 344 YCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVD 403
+C + C PC + +C S+ C C PGYSG+ CE+D DEC S+PC++G C+
Sbjct: 219 HCEREVLECASAPCEHNASCLEGLGSFRCLCWPGYSGELCEVDEDECASSPCQHGGRCLQ 278
Query: 404 ---------------GFNTFR------CLCLPSYVGALCEQDTETC 428
G +FR C C P + GA C + + C
Sbjct: 279 RSDPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCGVEVDEC 324
Score = 64.7 bits (156), Expect = 3e-10
Identities = 26/70 (37%), Positives = 33/70 (47%)
Query: 352 CKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFRCL 411
C +PCL+ G C ++ C C PG+ G +CE D CHS PC G F C
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRFECR 1119
Query: 412 CLPSYVGALC 421
C P + G C
Sbjct: 1120 CPPGFGGPRC 1129
Score = 62.0 bits (149), Expect = 2e-09
Identities = 39/133 (29%), Positives = 53/133 (39%), Gaps = 9/133 (6%)
Query: 294 CDYGWLSDASVRHPVTVARAQCGGGLLGVRTLYRFENQT--GFPPPDSRFDAYCFKRPDR 351
C GW H A C G RFE + GF P R P +
Sbjct: 1082 CGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRFECRCPPGFGGPRCRLPV-----PSK 1136
Query: 352 -CKMN-PCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFR 409
C +N CL+G C + C+C+ G +G +C++ C +NPC NG TC
Sbjct: 1137 ECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCEANPCLNGGTCRAAGGVSE 1196
Query: 410 CLCLPSYVGALCE 422
C+C + G CE
Sbjct: 1197 CICNARFSGQFCE 1209
Score = 50.4 bits (119), Expect = 5e-06
Identities = 23/62 (37%), Positives = 30/62 (48%), Gaps = 1/62 (1%)
Query: 350 DRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFR 409
D C +PC NGGTC T + CTC ++G C C PC ATC + + F
Sbjct: 809 DMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPCLPPATCEEVPDGFV 867
Query: 410 CL 411
C+
Sbjct: 868 CV 869
Score = 40.4 bits (93), Expect = 0.005
Identities = 15/36 (41%), Positives = 20/36 (55%)
Query: 388 DECHSNPCRNGATCVDGFNTFRCLCLPSYVGALCEQ 423
D C +PC NG TC+ +N F C C ++ G C Q
Sbjct: 809 DMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQ 844
Score = 39.3 bits (90), Expect = 0.012
Identities = 16/34 (47%), Positives = 19/34 (55%)
Query: 352 CKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCEL 385
C+ NPCLNGGTC C C +SG CE+
Sbjct: 1177 CEANPCLNGGTCRAAGGVSECICNARFSGQFCEV 1210
Score = 37.7 bits (86), Expect = 0.034
Identities = 14/39 (35%), Positives = 19/39 (48%)
Query: 390 CHSNPCRNGATCVDGFNTFRCLCLPSYVGALCEQDTETC 428
C +PC + C D F+ F C C P + G CE + C
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPC 1098
Score = 37.0 bits (84), Expect = 0.057
Identities = 14/44 (31%), Positives = 22/44 (50%)
Query: 388 DECHSNPCRNGATCVDGFNTFRCLCLPSYVGALCEQDTETCDYG 431
++C PC +G +CVD + FRC C + G C + +G
Sbjct: 607 EQCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCADEIPAATFG 650
Score = 34.7 bits (78), Expect = 0.29
Identities = 12/37 (32%), Positives = 21/37 (56%)
Query: 347 KRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQC 383
+R ++C+ PC++GG+C T + C C + G C
Sbjct: 604 ERREQCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTC 640
>gi|18641360 collectin sub-family member 12 [Homo sapiens]
Length = 742
Score = 91.3 bits (225), Expect = 3e-18
Identities = 43/128 (33%), Positives = 70/128 (54%), Gaps = 7/128 (5%)
Query: 428 CDYGWHKFQGQCYKYFAHRRTWDAAERECRLQGAHLTSILSHEEQMFVNR--VGHDYQWI 485
C W F +CY + + ++ A+ C + +HL I + EEQ ++ + VG + WI
Sbjct: 607 CPPHWKNFTDKCYYFSVEKEIFEDAKLFCEDKSSHLVFINTREEQQWIKKQMVGRESHWI 666
Query: 486 GLNDKMFEHDFRWTDGSTLQYENWRPNQPDSF---FSAGEDCVVIIWHENGQWNDVPCNY 542
GL D E++++W DG++ Y+NW+ QPD++ GEDC +I+ GQWND C
Sbjct: 667 GLTDSERENEWKWLDGTSPDYKNWKAGQPDNWGHGHGPGEDCAGLIY--AGQWNDFQCED 724
Query: 543 HLTYTCKK 550
+ C+K
Sbjct: 725 VNNFICEK 732
>gi|122937283 6720455I24Rik homolog [Homo sapiens]
Length = 1413
Score = 90.9 bits (224), Expect = 3e-18
Identities = 36/90 (40%), Positives = 51/90 (56%)
Query: 350 DRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFR 409
D C+ PCL+GG+C Y+C C GY G CEL+ DEC ++PCRNG +C + +
Sbjct: 755 DECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELERDECRAHPCRNGGSCRNLPGAYV 814
Query: 410 CLCLPSYVGALCEQDTETCDYGWHKFQGQC 439
C C +VG CE + + CD + G+C
Sbjct: 815 CRCPAGFVGVHCETEVDACDSSPCQHGGRC 844
Score = 90.5 bits (223), Expect = 4e-18
Identities = 39/90 (43%), Positives = 50/90 (55%), Gaps = 4/90 (4%)
Query: 354 MNPCLNGGTCYPT----ETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFR 409
+ PCLNGG C SY C+C+ G++G +C LD +EC S PC+NG TC G N+FR
Sbjct: 275 LRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQNGGTCTHGINSFR 334
Query: 410 CLCLPSYVGALCEQDTETCDYGWHKFQGQC 439
C C + G CE CD + GQC
Sbjct: 335 CQCPAGFGGPTCETAQSPCDTKECQHGGQC 364
Score = 83.2 bits (204), Expect = 7e-16
Identities = 33/86 (38%), Positives = 48/86 (55%)
Query: 343 AYCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCV 402
A+C D C+ +PC NGG+C +YVC C G+ G CE + D C S+PC++G C
Sbjct: 786 AHCELERDECRAHPCRNGGSCRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRCE 845
Query: 403 DGFNTFRCLCLPSYVGALCEQDTETC 428
G + C+C S+ G CE ++ C
Sbjct: 846 SGGGAYLCVCPESFFGYHCETVSDPC 871
Score = 80.9 bits (198), Expect = 3e-15
Identities = 33/79 (41%), Positives = 42/79 (53%)
Query: 348 RPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNT 407
+PD C PC NGGTC+ Y C C PG+SG CE+ C +PC NG TC D
Sbjct: 619 KPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRDTD 678
Query: 408 FRCLCLPSYVGALCEQDTE 426
F C C Y+G C+ + +
Sbjct: 679 FFCHCQAGYMGRRCQAEVD 697
Score = 75.9 bits (185), Expect = 1e-13
Identities = 35/97 (36%), Positives = 45/97 (46%), Gaps = 6/97 (6%)
Query: 326 YRFENQTGFPPPDSRFDAYCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCEL 385
+R + GF P C C C +GG C S VC C GY+G CE+
Sbjct: 333 FRCQCPAGFGGPT------CETAQSPCDTKECQHGGQCQVENGSAVCVCQAGYTGAACEM 386
Query: 386 DFDECHSNPCRNGATCVDGFNTFRCLCLPSYVGALCE 422
D D+C +PC NG +CVD + CLC + G CE
Sbjct: 387 DVDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCE 423
Score = 72.8 bits (177), Expect = 9e-13
Identities = 35/96 (36%), Positives = 45/96 (46%), Gaps = 2/96 (2%)
Query: 349 PDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDE-CHSNPCRNGATCVDGFNT 407
P C +PC NGG+C + SY C C G+ G CE C S PCRNG TC +
Sbjct: 542 PSPCDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGE 601
Query: 408 FRCLCLPSYVGALCE-QDTETCDYGWHKFQGQCYKY 442
+ C C + G CE ++C G G C+ Y
Sbjct: 602 YHCSCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHY 637
Score = 72.4 bits (176), Expect = 1e-12
Identities = 34/87 (39%), Positives = 42/87 (48%), Gaps = 2/87 (2%)
Query: 344 YCFK-RPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDF-DECHSNPCRNGATC 401
+C K RP C PC NGGTC Y C+C ++G CE+ D C S PC NG TC
Sbjct: 575 HCEKARPHLCSSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCEIGKPDSCASGPCHNGGTC 634
Query: 402 VDGFNTFRCLCLPSYVGALCEQDTETC 428
++C C P + G CE C
Sbjct: 635 FHYIGKYKCDCPPGFSGRHCEIAPSPC 661
Score = 68.6 bits (166), Expect = 2e-11
Identities = 29/84 (34%), Positives = 38/84 (45%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDG 404
C + C PC NGGTC S+ C C G+ G CE C + C++G C
Sbjct: 308 CHLDVNECASQPCQNGGTCTHGINSFRCQCPAGFGGPTCETAQSPCDTKECQHGGQCQVE 367
Query: 405 FNTFRCLCLPSYVGALCEQDTETC 428
+ C+C Y GA CE D + C
Sbjct: 368 NGSAVCVCQAGYTGAACEMDVDDC 391
Score = 66.6 bits (161), Expect = 7e-11
Identities = 40/107 (37%), Positives = 48/107 (44%), Gaps = 14/107 (13%)
Query: 349 PDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQC-ELDFDECHSNPCRNGATCVDGFNT 407
PD C PC NGGTC + YVC C G+ G C E D+C CRNG C+ G NT
Sbjct: 430 PDACLSAPCHNGGTCVDADQGYVCECPEGFMGLDCRERVPDDCE---CRNGGRCL-GANT 485
Query: 408 FRCLCLPSYVGALCE---------QDTETCDYGWHKFQGQCYKYFAH 445
C C + G LCE +T+ D G+ G Y H
Sbjct: 486 TLCQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCH 532
Score = 60.1 bits (144), Expect = 6e-09
Identities = 25/81 (30%), Positives = 36/81 (44%)
Query: 344 YCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVD 403
+C D C +PC +GG C +Y+C C + G CE D C S+PC C+
Sbjct: 825 HCETEVDACDSSPCQHGGRCESGGGAYLCVCPESFFGYHCETVSDPCFSSPCGGRGYCLA 884
Query: 404 GFNTFRCLCLPSYVGALCEQD 424
+ C C Y G C ++
Sbjct: 885 SNGSHSCTCKVGYTGEDCAKE 905
Score = 54.7 bits (130), Expect = 3e-07
Identities = 37/144 (25%), Positives = 48/144 (33%), Gaps = 60/144 (41%)
Query: 344 YCFKRPDRCKMNPCLNGGTCYPTETSYVC------------------------------- 372
+C P C +PC+NGGTC +T + C
Sbjct: 653 HCEIAPSPCFRSPCVNGGTCEDRDTDFFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFN 712
Query: 373 ----------TCVPGYS------------------GDQCELDFDECHSNPCRNGATCVDG 404
C GYS QC L+ DEC S PC +G +C D
Sbjct: 713 GTRLGAVALYACDRGYSLSAPSRIRVCQPHGVWSEPPQC-LEIDECRSQPCLHGGSCQDR 771
Query: 405 FNTFRCLCLPSYVGALCEQDTETC 428
+ CLC Y GA CE + + C
Sbjct: 772 VAGYLCLCSTGYEGAHCELERDEC 795
Score = 51.6 bits (122), Expect = 2e-06
Identities = 22/47 (46%), Positives = 27/47 (57%), Gaps = 1/47 (2%)
Query: 349 PDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPC 395
P C NPC NGGTC P ++ C C PG+ G +CEL + S PC
Sbjct: 1308 PGNCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKV-SRPC 1353
Score = 43.1 bits (100), Expect = 8e-04
Identities = 18/47 (38%), Positives = 25/47 (53%)
Query: 337 PDSRFDAYCFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQC 383
P+S F +C D C +PC G C + S+ CTC GY+G+ C
Sbjct: 856 PESFFGYHCETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGEDC 902
Score = 42.4 bits (98), Expect = 0.001
Identities = 16/33 (48%), Positives = 19/33 (57%)
Query: 390 CHSNPCRNGATCVDGFNTFRCLCLPSYVGALCE 422
C NPC+NG TCV G + C C P + G CE
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCE 1343
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 90.1 bits (222), Expect = 6e-18
Identities = 34/80 (42%), Positives = 52/80 (65%), Gaps = 3/80 (3%)
Query: 352 CKMNPCLNGGTCYPTET---SYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTF 408
C NPC +GGTC+ +++ + C+C G+ G +CE++ D+C N C N ATCVDG N +
Sbjct: 959 CIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNY 1018
Query: 409 RCLCLPSYVGALCEQDTETC 428
C+C P+Y G LC++ + C
Sbjct: 1019 VCICPPNYTGELCDEVIDHC 1038
Score = 77.8 bits (190), Expect = 3e-14
Identities = 36/94 (38%), Positives = 48/94 (51%), Gaps = 9/94 (9%)
Query: 345 CFKRPDRC--KMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCV 402
C + D C ++N C + C P + + C CVPGYSG CE D D+C ++ CR+GA CV
Sbjct: 1031 CDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCV 1090
Query: 403 DGFNTFRCLCLPSYVGALCEQ-------DTETCD 429
D N + C C + G CE T CD
Sbjct: 1091 DTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCD 1124
Score = 76.3 bits (186), Expect = 9e-14
Identities = 34/86 (39%), Positives = 44/86 (51%), Gaps = 2/86 (2%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDEC--HSNPCRNGATCV 402
C PD C+ N C N TC +YVC C P Y+G+ C+ D C N C++ A C+
Sbjct: 993 CEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCI 1052
Query: 403 DGFNTFRCLCLPSYVGALCEQDTETC 428
F C C+P Y G LCE D + C
Sbjct: 1053 PLDKGFSCECVPGYSGKLCETDNDDC 1078
Score = 58.5 bits (140), Expect = 2e-08
Identities = 29/86 (33%), Positives = 36/86 (41%), Gaps = 7/86 (8%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCE-------LDFDECHSNPCRN 397
C D C + C +G C T Y CTC G+SG CE L C C+N
Sbjct: 1071 CETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQN 1130
Query: 398 GATCVDGFNTFRCLCLPSYVGALCEQ 423
GA C+ C C P + G CE+
Sbjct: 1131 GAQCIVVQQEPTCRCPPGFAGPRCEK 1156
Score = 54.3 bits (129), Expect = 3e-07
Identities = 28/82 (34%), Positives = 39/82 (47%), Gaps = 7/82 (8%)
Query: 350 DRCKMNPCL----NGGTCYPTETSYVCTCVPGYSGDQCELDFDE---CHSNPCRNGATCV 402
D+ +PCL + G C T TSY+C C GY GD C+ D C + C +G +
Sbjct: 1365 DQEARDPCLGHRCHHGKCVATGTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHI 1424
Query: 403 DGFNTFRCLCLPSYVGALCEQD 424
CLC P + G C+Q+
Sbjct: 1425 SDQGEPYCLCQPGFSGEHCQQE 1446
Score = 47.0 bits (110), Expect = 6e-05
Identities = 29/93 (31%), Positives = 41/93 (44%), Gaps = 5/93 (5%)
Query: 352 CKMNPCLNGGTCYPTET-SYVCTCVPGYSGDQCELDF-DECHSNPCRNGATCVDGFNTFR 409
CK G C E S VC C PG++G C+ + D C + C +G CV ++
Sbjct: 1332 CKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHG-KCVATGTSYM 1390
Query: 410 CLCLPSYVGALCE--QDTETCDYGWHKFQGQCY 440
C C Y G LC+ D+ + GQC+
Sbjct: 1391 CKCAEGYGGDLCDNKNDSANACSAFKCHHGQCH 1423
Score = 40.4 bits (93), Expect = 0.005
Identities = 20/58 (34%), Positives = 27/58 (46%), Gaps = 1/58 (1%)
Query: 390 CHSNPCRNGATCV-DGFNTFRCLCLPSYVGALCEQDTETCDYGWHKFQGQCYKYFAHR 446
C S+PC+N TC D +RC C SY G C TC + G C+ +H+
Sbjct: 920 CLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHK 977
>gi|8393264 delta-like 3 protein isoform 1 precursor [Homo sapiens]
Length = 618
Score = 89.0 bits (219), Expect = 1e-17
Identities = 38/100 (38%), Positives = 51/100 (51%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDG 404
C KR DRC + PC NGG C + C C G++G +CE D D+C C NG TCV+G
Sbjct: 350 CEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEG 409
Query: 405 FNTFRCLCLPSYVGALCEQDTETCDYGWHKFQGQCYKYFA 444
RC C + G C + + C G+CY +F+
Sbjct: 410 GGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFS 449
Score = 80.1 bits (196), Expect = 6e-15
Identities = 32/80 (40%), Positives = 41/80 (51%), Gaps = 3/80 (3%)
Query: 352 CKMNPCLNGGTCY---PTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTF 408
C PC NGG C +++Y+C C PG+ G CE D C PCRNG C+D +
Sbjct: 316 CADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHAL 375
Query: 409 RCLCLPSYVGALCEQDTETC 428
RC C + G CE D + C
Sbjct: 376 RCRCRAGFAGPRCEHDLDDC 395
Score = 74.3 bits (181), Expect = 3e-13
Identities = 33/83 (39%), Positives = 44/83 (53%), Gaps = 3/83 (3%)
Query: 349 PDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGF--- 405
P C NPC NGG+C T S+ CTC G+ G +CE+ C PC NG CV G
Sbjct: 275 PGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPD 334
Query: 406 NTFRCLCLPSYVGALCEQDTETC 428
+ + C C P + G+ CE+ + C
Sbjct: 335 SAYICHCPPGFQGSNCEKRVDRC 357
Score = 41.2 bits (95), Expect = 0.003
Identities = 28/114 (24%), Positives = 38/114 (33%), Gaps = 28/114 (24%)
Query: 345 CFKRPDRCKMNPCLNGGTCYPT----ETSYVCTCVPGYSGDQCELDFDE----------- 389
C D C+ P + C P E C C+ G++G C +
Sbjct: 207 CAPLEDECEA-PLVCRAGCSPEHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSS 265
Query: 390 ------------CHSNPCRNGATCVDGFNTFRCLCLPSYVGALCEQDTETCDYG 431
C NPC NG +C + +F C C + G CE TC G
Sbjct: 266 ATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADG 319
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.452
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,283,755
Number of Sequences: 37866
Number of extensions: 1365510
Number of successful extensions: 6079
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 279
Number of HSP's successfully gapped in prelim test: 236
Number of HSP's that attempted gapping in prelim test: 3025
Number of HSP's gapped (non-prelim): 2162
length of query: 655
length of database: 18,247,518
effective HSP length: 109
effective length of query: 546
effective length of database: 14,120,124
effective search space: 7709587704
effective search space used: 7709587704
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.