Search of human proteins with 10190722

Search of human proteins with 10190722

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|10190722 leucine-rich repeats and transmembrane domains 1
[Homo sapiens]
         (345 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|10190722 leucine-rich repeats and transmembrane domains 1 [Ho...   712   0.0  
gi|84781739 leucine-rich repeats and transmembrane domains 2 [Ho...   219   3e-57
gi|41582239 immunoglobulin superfamily containing leucine-rich r...   119   3e-27
gi|5031809 immunoglobulin superfamily containing leucine-rich re...   119   3e-27
gi|11321571 slit homolog 3 [Homo sapiens]                             119   4e-27
gi|4759146 slit homolog 2 [Homo sapiens]                              114   1e-25
gi|229089140 leucine rich repeat containing 24 [Homo sapiens]         112   4e-25
gi|188528675 slit homolog 1 [Homo sapiens]                            110   1e-24
gi|194306623 immunoglobulin superfamily containing leucine-rich ...   104   1e-22
gi|194306621 immunoglobulin superfamily containing leucine-rich ...   104   1e-22
gi|39930401 immunoglobulin superfamily containing leucine-rich r...   104   1e-22
gi|194306618 immunoglobulin superfamily containing leucine-rich ...   104   1e-22
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s...   103   2e-22
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa...   103   2e-22
gi|40217825 slit and trk like 6 [Homo sapiens]                        102   4e-22
gi|40217817 slit and trk like 1 protein [Homo sapiens]                100   1e-21
gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]                 98   1e-20
gi|40217820 slit and trk like 3 protein [Homo sapiens]                 97   2e-20
gi|153251229 chondroadherin precursor [Homo sapiens]                   97   2e-20
gi|239752702 PREDICTED: leucine rich repeat containing 38, parti...    97   2e-20
gi|61966761 leucine rich repeat containing 26 [Homo sapiens]           97   3e-20
gi|40217823 SLIT and NTRK-like family, member 5 [Homo sapiens]         96   4e-20
gi|109150416 peroxidasin [Homo sapiens]                                96   6e-20
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]    95   1e-19
gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo sa...    94   2e-19
gi|76880480 hypothetical protein LOC9865 [Homo sapiens]                94   2e-19
gi|221136985 SLIT and NTRK-like family, member 2 [Homo sapiens]        93   3e-19
gi|221136981 SLIT and NTRK-like family, member 2 [Homo sapiens]        93   3e-19
gi|221136977 SLIT and NTRK-like family, member 2 [Homo sapiens]        93   3e-19
gi|221136973 SLIT and NTRK-like family, member 2 [Homo sapiens]        93   3e-19

>gi|10190722 leucine-rich repeats and transmembrane domains 1 [Homo
           sapiens]
          Length = 345

 Score =  712 bits (1837), Expect = 0.0
 Identities = 345/345 (100%), Positives = 345/345 (100%)

Query: 1   MKGELLLFSSVIVLLQVVCSCPDKCYCQSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDN 60
           MKGELLLFSSVIVLLQVVCSCPDKCYCQSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDN
Sbjct: 1   MKGELLLFSSVIVLLQVVCSCPDKCYCQSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDN 60

Query: 61  QIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHS 120
           QIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHS
Sbjct: 61  QIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHS 120

Query: 121 LPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDN 180
           LPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDN
Sbjct: 121 LPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDN 180

Query: 181 LWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELYQPCPLPAPDPV 240
           LWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELYQPCPLPAPDPV
Sbjct: 181 LWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELYQPCPLPAPDPV 240

Query: 241 SSQAQWPGSAHGVVLRPPENHNAGERELLECELKPKPRPANLRHAIATVIITGVVCGIVC 300
           SSQAQWPGSAHGVVLRPPENHNAGERELLECELKPKPRPANLRHAIATVIITGVVCGIVC
Sbjct: 241 SSQAQWPGSAHGVVLRPPENHNAGERELLECELKPKPRPANLRHAIATVIITGVVCGIVC 300

Query: 301 LMMLAAAIYGCTYAAITAQYHGGPLAQTNDPGKVEEKERFDSSPA 345
           LMMLAAAIYGCTYAAITAQYHGGPLAQTNDPGKVEEKERFDSSPA
Sbjct: 301 LMMLAAAIYGCTYAAITAQYHGGPLAQTNDPGKVEEKERFDSSPA 345


>gi|84781739 leucine-rich repeats and transmembrane domains 2 [Homo
           sapiens]
          Length = 370

 Score =  219 bits (558), Expect = 3e-57
 Identities = 119/311 (38%), Positives = 174/311 (55%), Gaps = 4/311 (1%)

Query: 15  LQVVCSCPDKCYCQSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAFRSVP 74
           ++ + +CP  C C S +  VDCS  GL  +P  +P  TRTL L +N++  LP++AF ++ 
Sbjct: 33  VEALPTCPFSCKCDSRSLEVDCSGLGLTTVPPDVPAATRTLLLLNNKLSALPSWAFANLS 92

Query: 75  WLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLSSNNI 134
            L  L+LSNN L  L    F  L +L  L L  NS+ +L+  L    P LR LDLS N +
Sbjct: 93  SLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGL 152

Query: 135 SHLPTSLGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDNLWKCNCHLLGLKLW 194
           + LP  L +    L  L+++ N+LQ LDR   E + +++LL + DN W+C+C+L   K W
Sbjct: 153 AQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDNPWECDCNLREFKHW 212

Query: 195 LEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELYQPCPLPAPDPVSSQAQWPG----SA 250
           +E F Y+GG  D + C  P   +GKD+  +P E++  C     +  S+    PG     A
Sbjct: 213 MEWFSYRGGRLDQLACTLPKELRGKDMRMVPMEMFNYCSQLEDENSSAGLDIPGPPCTKA 272

Query: 251 HGVVLRPPENHNAGERELLECELKPKPRPANLRHAIATVIITGVVCGIVCLMMLAAAIYG 310
                +P             C  K + RPA++R A+ TVII GVVCG+VC+MM+ AA YG
Sbjct: 273 SPEPAKPKPGAEPEPEPSTACPQKQRHRPASVRRAMGTVIIAGVVCGVVCIMMVVAAAYG 332

Query: 311 CTYAAITAQYH 321
           C YA++ A+YH
Sbjct: 333 CIYASLMAKYH 343


>gi|41582239 immunoglobulin superfamily containing leucine-rich
           repeat [Homo sapiens]
          Length = 428

 Score =  119 bits (299), Expect = 3e-27
 Identities = 81/269 (30%), Positives = 121/269 (44%), Gaps = 16/269 (5%)

Query: 13  VLLQVVCSCPDKCYCQSSTNF--VDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAF 70
           +LL +  +CP+ C C     F   DC+ + L  +P   P    TL L  N++  LP  AF
Sbjct: 11  LLLGLAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAF 70

Query: 71  RSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLS 130
           R VP L +L L++N +  +A GA   L HL+ L+L+ N +        H+L  L+ L + 
Sbjct: 71  REVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMD 130

Query: 131 SNNISHLPTSLGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDNLWKCNCHLLG 190
           SN ++ +P     +   L  L +  N+L  L       + ++  L + +N + C C ++ 
Sbjct: 131 SNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVW 190

Query: 191 LKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELYQPCPLPAPDPVSSQAQWPGSA 250
           LK W           D I C SP   KG  L R+P     P P  AP   S Q  +  S 
Sbjct: 191 LKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLP-----PLPCSAP---SVQLSYQPSQ 242

Query: 251 HGVVLRPPENHNAGERELLECELKPKPRP 279
            G  LRP      G    L C++  +P P
Sbjct: 243 DGAELRP------GFVLALHCDVDGQPAP 265


>gi|5031809 immunoglobulin superfamily containing leucine-rich
           repeat [Homo sapiens]
          Length = 428

 Score =  119 bits (299), Expect = 3e-27
 Identities = 81/269 (30%), Positives = 121/269 (44%), Gaps = 16/269 (5%)

Query: 13  VLLQVVCSCPDKCYCQSSTNF--VDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAF 70
           +LL +  +CP+ C C     F   DC+ + L  +P   P    TL L  N++  LP  AF
Sbjct: 11  LLLGLAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAF 70

Query: 71  RSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLS 130
           R VP L +L L++N +  +A GA   L HL+ L+L+ N +        H+L  L+ L + 
Sbjct: 71  REVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMD 130

Query: 131 SNNISHLPTSLGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDNLWKCNCHLLG 190
           SN ++ +P     +   L  L +  N+L  L       + ++  L + +N + C C ++ 
Sbjct: 131 SNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVW 190

Query: 191 LKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELYQPCPLPAPDPVSSQAQWPGSA 250
           LK W           D I C SP   KG  L R+P     P P  AP   S Q  +  S 
Sbjct: 191 LKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLP-----PLPCSAP---SVQLSYQPSQ 242

Query: 251 HGVVLRPPENHNAGERELLECELKPKPRP 279
            G  LRP      G    L C++  +P P
Sbjct: 243 DGAELRP------GFVLALHCDVDGQPAP 265


>gi|11321571 slit homolog 3 [Homo sapiens]
          Length = 1523

 Score =  119 bits (298), Expect = 4e-27
 Identities = 71/212 (33%), Positives = 112/212 (52%), Gaps = 7/212 (3%)

Query: 20  SCPDKCYCQSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAFRSVPWLMTL 79
           SCP  C C  S N VDC  +GL EIP++LP     + L+ N I  +PA AF     L  +
Sbjct: 279 SCPSPCTC--SNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRI 336

Query: 80  NLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLSSNNISHLPT 139
           ++S N +S++AP AF GL+ L  L L  N +  +   LF  L  L+ L L++N I+ L  
Sbjct: 337 DISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRV 396

Query: 140 SLGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDNLWKCNCHLLGLKLWLEKFV 199
           +  +  +NL +L++  N+LQ + + L   + S++ L L  N + C+CHL     WL  ++
Sbjct: 397 NTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHL----KWLADYL 452

Query: 200 YKGGL-TDGIICESPDTWKGKDLLRIPHELYQ 230
               + T G  C SP     K + +I  + ++
Sbjct: 453 QDNPIETSGARCSSPRRLANKRISQIKSKKFR 484



 Score =  112 bits (281), Expect = 4e-25
 Identities = 64/178 (35%), Positives = 93/178 (52%), Gaps = 3/178 (1%)

Query: 21  CPDKCYCQSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFA-FRSVPWLMTL 79
           CP+KC C+ +   VDCS Q L  IPSHLP     L L DN++  L A   F+ +P L  +
Sbjct: 505 CPEKCRCEGT--IVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKI 562

Query: 80  NLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLSSNNISHLPT 139
           NLSNN +  +  GAF G   +Q L LT N L ++  R+F  L  L+ L L SN I  +  
Sbjct: 563 NLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSN 622

Query: 140 SLGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDNLWKCNCHLLGLKLWLEK 197
                  ++ +L++  N++  +      ++ S+  + L  N + CNCHL  L  WL K
Sbjct: 623 DTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRK 680



 Score =  102 bits (255), Expect = 4e-22
 Identities = 73/249 (29%), Positives = 106/249 (42%), Gaps = 30/249 (12%)

Query: 20  SCPDKCYCQSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAFRSVPWLMTL 79
           +CP KC C +++  VDC   GL  +P  +P     L L  N I  +    F  +  L  L
Sbjct: 33  ACPTKCTCSAAS--VDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVL 90

Query: 80  NLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLSSNNISHLP- 138
           +L +N +S +  GAF  L+ L+ L L +N L  L   LF S P+L  LDLS N I  +P 
Sbjct: 91  HLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPR 150

Query: 139 -----------------------TSLGETWENLTILAVQQNQLQQLDRALLESMPSVRLL 175
                                          +L IL +  N + ++       MP +R L
Sbjct: 151 KAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTL 210

Query: 176 LLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELYQPCPLP 235
            L  N   C+CHL  L  WL +    G  T   +C +P   +G ++  +  + Y  CP P
Sbjct: 211 RLHSNHLYCDCHLAWLSDWLRQRRTVGQFT---LCMAPVHLRGFNVADVQKKEY-VCPAP 266

Query: 236 APDPVSSQA 244
             +P S  A
Sbjct: 267 HSEPPSCNA 275



 Score = 72.4 bits (176), Expect = 6e-13
 Identities = 55/211 (26%), Positives = 87/211 (41%), Gaps = 32/211 (15%)

Query: 21  CPDKCYCQSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAFRSVPWLMTLN 80
           CP++C C  +   V CS +GL  +P  +P     L+L+ N   HL A             
Sbjct: 725 CPEQCTCMETV--VRCSNKGLRALPRGMPKDVTELYLEGN---HLTA------------- 766

Query: 81  LSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLSSNNISHLPTS 140
                     P     L+HL +++L+ NS+  L +  F ++  L  L LS N +  +P  
Sbjct: 767 ---------VPRELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVH 817

Query: 141 LGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDNLWKCNCHLLGLKLWLEKFVY 200
                 +L +L +  N +  +       + S+  L L  N   C+C L     WL ++V 
Sbjct: 818 AFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSL----RWLSEWVK 873

Query: 201 KGGLTDGII-CESPDTWKGKDLLRIPHELYQ 230
            G    GI  C SP+    + LL  P   +Q
Sbjct: 874 AGYKEPGIARCSSPEPMADRLLLTTPTHRFQ 904


>gi|4759146 slit homolog 2 [Homo sapiens]
          Length = 1529

 Score =  114 bits (286), Expect = 1e-25
 Identities = 71/214 (33%), Positives = 109/214 (50%), Gaps = 7/214 (3%)

Query: 18  VCSCPDKCYCQSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAFRSVPWLM 77
           V  CP  C C  S N VDC  +GL EIP++LP     + L+ N I  +P  AF     L 
Sbjct: 270 VLHCPAACTC--SNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLR 327

Query: 78  TLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLSSNNISHL 137
            ++LSNN +S LAP AF GL+ L  L L  N +  L   LF  L  L+ L L++N I+ L
Sbjct: 328 RIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCL 387

Query: 138 PTSLGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDNLWKCNCHLLGLKLWLEK 197
                +   NL +L++  N+LQ + +     + +++ + L  N + C+CHL     WL  
Sbjct: 388 RVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHL----KWLAD 443

Query: 198 FVYKGGL-TDGIICESPDTWKGKDLLRIPHELYQ 230
           +++   + T G  C SP     K + +I  + ++
Sbjct: 444 YLHTNPIETSGARCTSPRRLANKRIGQIKSKKFR 477



 Score =  108 bits (271), Expect = 5e-24
 Identities = 64/195 (32%), Positives = 104/195 (53%), Gaps = 6/195 (3%)

Query: 20  SCPDKCYCQSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFA-FRSVPWLMT 78
           +CP+KC C+ +T  VDCS Q L +IP H+P  T  L L +N+   L A   F+ +P L  
Sbjct: 505 ACPEKCRCEGTT--VDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRK 562

Query: 79  LNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLSSNNISHLP 138
           +N SNN ++++  GAF G   +  + LT N L +++ ++F  L  L+ L L SN I+ + 
Sbjct: 563 INFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVG 622

Query: 139 TSLGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDNLWKCNCHLLGLKLWLEKF 198
                   ++ +L++  NQ+  +     +++ S+  L L  N + CNC+L  L  WL K 
Sbjct: 623 NDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGEWLRK- 681

Query: 199 VYKGGLTDGIICESP 213
             K  +T    C+ P
Sbjct: 682 --KRIVTGNPRCQKP 694



 Score = 90.1 bits (222), Expect = 3e-18
 Identities = 67/240 (27%), Positives = 95/240 (39%), Gaps = 31/240 (12%)

Query: 11  VIVLLQVVC--SCPDKCYCQSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAF 68
           V+ +L  V   +CP +C C  ST  VDC    L  +P ++P  T  L L  N I  +   
Sbjct: 16  VLAILNKVAPQACPAQCSCSGST--VDCHGLALRSVPRNIPRNTERLDLNGNNITRITKT 73

Query: 69  AFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELD 128
            F  +  L  L L  N +S +  GAF  L+ L+ L L +N L      LF    +L  LD
Sbjct: 74  DFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLD 133

Query: 129 LSSNNISHLP------------------------TSLGETWENLTILAVQQNQLQQLDRA 164
           LS N I  +P                                +L +L +  N + +L  A
Sbjct: 134 LSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVA 193

Query: 165 LLESMPSVRLLLLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRI 224
               MP +R   L  N   C+CHL  L  WL +    G  T    C  P   +G ++  +
Sbjct: 194 SFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQ---CMGPSHLRGHNVAEV 250



 Score = 69.3 bits (168), Expect = 5e-12
 Identities = 56/209 (26%), Positives = 85/209 (40%), Gaps = 30/209 (14%)

Query: 21  CPDKCYCQSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAFRSVPWLMTLN 80
           CP +C C  +   V CS +GL  +P  +P     L+L  NQ   +P     +   L  ++
Sbjct: 727 CPTECTCLDTV--VRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPK-ELSNYKHLTLID 783

Query: 81  LSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLSSNNISHLPTS 140
           LSNN +S L+  +F  +  L  L L+ N L  +  R F  L  LR L L  N+IS +P  
Sbjct: 784 LSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEG 843

Query: 141 LGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDNLWKCNCHLLGLKLWLEKFVY 200
                  L+ LA+  N L                         C+C++  L  W++    
Sbjct: 844 AFNDLSALSHLAIGANPLY------------------------CDCNMQWLSDWVKSEYK 879

Query: 201 KGGLTDGIICESPDTWKGKDLLRIPHELY 229
           + G+     C  P     K LL  P + +
Sbjct: 880 EPGIAR---CAGPGEMADKLLLTTPSKKF 905


>gi|229089140 leucine rich repeat containing 24 [Homo sapiens]
          Length = 513

 Score =  112 bits (281), Expect = 4e-25
 Identities = 97/310 (31%), Positives = 139/310 (44%), Gaps = 54/310 (17%)

Query: 1   MKGELLLFSSVIVLLQVVCSCPDKCYCQSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDN 60
           ++   LL   +++L      CP  C C S+T  V+C    L  +P  +PP T+TL LQDN
Sbjct: 3   LRAPALLPLLLLLLPLRAAGCPAACRCYSAT--VECGALRLRVVPLGIPPGTQTLFLQDN 60

Query: 61  QIHHLP------------------------AFAFRSVPWLMTLNLSNNSLSNLAPGAFHG 96
            I  L                         A AFR+ P L+ L L++N L  L  GAF G
Sbjct: 61  NIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVG 120

Query: 97  LQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQN 156
           L  L+VL L  N L  L    F  LP+L+EL L  N+I  L         +L +L + +N
Sbjct: 121 LAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRN 180

Query: 157 QLQQLDRALLESMPSVRLLLLKDNLWKCNCHLLGLKLWLEKFVYKGG---LTD---GIIC 210
           QL  + R  L+ + S+++L L +N W+C+C L     WL  ++ +GG   LT     I+C
Sbjct: 181 QLGTISREALQPLASLQVLRLTENPWRCDCAL----HWLGAWIKEGGQRLLTSRDRKIMC 236

Query: 211 ESPDTWKGKDLLRIPHELYQPCPLPAPDPVSSQAQWPGSAHGVVLRPPE-NHNAGERELL 269
             P     + LL + H              SS    P S H   ++P E   N GE   +
Sbjct: 237 AEPPRLALQSLLDVSH--------------SSLICIPPSVH---VQPLELTANLGEDLRV 279

Query: 270 ECELKPKPRP 279
            C+    P+P
Sbjct: 280 ACQASGYPQP 289


>gi|188528675 slit homolog 1 [Homo sapiens]
          Length = 1534

 Score =  110 bits (276), Expect = 1e-24
 Identities = 68/195 (34%), Positives = 101/195 (51%), Gaps = 6/195 (3%)

Query: 21  CPDKCYCQSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFA-FRSVPWLMTL 79
           CP KC C++  N V+CS   L +IP  +P  T  L L +N+I  L A   F+ +  L  +
Sbjct: 513 CPHKCRCEA--NVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKI 570

Query: 80  NLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLSSNNISHLPT 139
           NLSNN +S +  GAF G   +  L+LT N L S+ S +F  L  LR L L +N IS +  
Sbjct: 571 NLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHN 630

Query: 140 SLGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDNLWKCNCHLLGLKLWLEKFV 199
                  N+ +L++  NQ+  +     +++ S+  L L  N + CNC L  L  WL K  
Sbjct: 631 DSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRK-- 688

Query: 200 YKGGLTDGIICESPD 214
            +  +T    C++PD
Sbjct: 689 -RKIVTGNPRCQNPD 702



 Score =  104 bits (259), Expect = 1e-22
 Identities = 67/212 (31%), Positives = 109/212 (51%), Gaps = 7/212 (3%)

Query: 20  SCPDKCYCQSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAFRSVPWLMTL 79
           SCP  C C  S   VDC  +GL  IP++LP     + L+ N I  +P  AF     L  +
Sbjct: 281 SCPAMCTC--SNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRI 338

Query: 80  NLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLSSNNISHLPT 139
           +LSNN ++ +AP AF GL+ L  L L  N +  L   +F  L  L+ L L++N I+ +  
Sbjct: 339 DLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRP 398

Query: 140 SLGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDNLWKCNCHLLGLKLWLEKFV 199
              +  +NL++L++  N++Q L +    S+ +++ L L  N + C+C+L     WL  F+
Sbjct: 399 DAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNL----KWLADFL 454

Query: 200 YKGGL-TDGIICESPDTWKGKDLLRIPHELYQ 230
               + T G  C SP     K + +I  + ++
Sbjct: 455 RTNPIETSGARCASPRRLANKRIGQIKSKKFR 486



 Score = 87.0 bits (214), Expect = 2e-17
 Identities = 66/229 (28%), Positives = 94/229 (41%), Gaps = 29/229 (12%)

Query: 20  SCPDKCYCQSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAFRSVPWLMTL 79
           +CP  C C  +T  VDC   GL  IP ++P  T  L L  N I  +    F  +  L  L
Sbjct: 33  ACPALCTCTGTT--VDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVL 90

Query: 80  NLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLSSNNISHLPT 139
            L  N +  +  GAF  ++ L+ L L +N L  L   LF +   L  LDLS N I  +P 
Sbjct: 91  QLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPR 150

Query: 140 SLGETWENLTILAVQQNQLQQLD----RAL--------------------LESMPSVRLL 175
                  +L  L + +NQ+  ++    RAL                       MP +R  
Sbjct: 151 KAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTF 210

Query: 176 LLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRI 224
            L  N   C+CHL  L  WL +    G  T    C  P + +G ++  +
Sbjct: 211 RLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQ---CSGPASLRGLNVAEV 256



 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 60/211 (28%), Positives = 90/211 (42%), Gaps = 32/211 (15%)

Query: 21  CPDKCYCQSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAFRSVPWLMTLN 80
           CP +C C  +   V CS + L  +P  +P     L+L  NQ   +P     +  +L  ++
Sbjct: 734 CPQECACLDTV--VRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPG-QLSTFKYLQLVD 790

Query: 81  LSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLSSNNISHLPTS 140
           LSNN +S+L+  +F  +  L  L L+ N+L  +    F  L  LR L L  N+IS L   
Sbjct: 791 LSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEG 850

Query: 141 LGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDNLWKCNCHLLGLKLWLEKFVY 200
           +     +L+ LA+  N L                         C+CHL     WL  +V 
Sbjct: 851 IFADVTSLSHLAIGANPLY------------------------CDCHLR----WLSSWVK 882

Query: 201 KGGLTDGII-CESPDTWKGKDLLRIPHELYQ 230
            G    GI  C  P   +GK LL  P + ++
Sbjct: 883 TGYKEPGIARCAGPQDMEGKLLLTTPAKKFE 913


>gi|194306623 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score =  104 bits (260), Expect = 1e-22
 Identities = 82/271 (30%), Positives = 121/271 (44%), Gaps = 14/271 (5%)

Query: 11  VIVLLQVVCSCPDKCYC--QSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAF 68
           V  LL V  SCP+ C C  + +  F DC+ + L E+P  LP    TL L  N+I  L   
Sbjct: 10  VWALLGVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRG 69

Query: 69  AFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELD 128
           AF  V  + +L L++N +  + PGA   L  L+ L+L+ N + S       +L  L+ L 
Sbjct: 70  AFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLK 129

Query: 129 LSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDNLWKCNCHL 188
           ++ N +  LP        +L  L +  N+L+ L     +++ ++  L L  N + C C L
Sbjct: 130 MNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGL 189

Query: 189 LGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELYQPCPLPAPDPVSSQAQWPG 248
           + L+ W           D I C SP   +G  + R+P     PC   AP  V   A+ P 
Sbjct: 190 VWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRLP---ALPC---APPSVHLSAEPPL 243

Query: 249 SAHGVVLRPPENHNAGERELLECELKPKPRP 279
            A G  LR      AG   +L C     P P
Sbjct: 244 EAPGTPLR------AGLAFVLHCIADGHPTP 268


>gi|194306621 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score =  104 bits (260), Expect = 1e-22
 Identities = 82/271 (30%), Positives = 121/271 (44%), Gaps = 14/271 (5%)

Query: 11  VIVLLQVVCSCPDKCYC--QSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAF 68
           V  LL V  SCP+ C C  + +  F DC+ + L E+P  LP    TL L  N+I  L   
Sbjct: 10  VWALLGVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRG 69

Query: 69  AFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELD 128
           AF  V  + +L L++N +  + PGA   L  L+ L+L+ N + S       +L  L+ L 
Sbjct: 70  AFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLK 129

Query: 129 LSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDNLWKCNCHL 188
           ++ N +  LP        +L  L +  N+L+ L     +++ ++  L L  N + C C L
Sbjct: 130 MNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGL 189

Query: 189 LGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELYQPCPLPAPDPVSSQAQWPG 248
           + L+ W           D I C SP   +G  + R+P     PC   AP  V   A+ P 
Sbjct: 190 VWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRLP---ALPC---APPSVHLSAEPPL 243

Query: 249 SAHGVVLRPPENHNAGERELLECELKPKPRP 279
            A G  LR      AG   +L C     P P
Sbjct: 244 EAPGTPLR------AGLAFVLHCIADGHPTP 268


>gi|39930401 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score =  104 bits (260), Expect = 1e-22
 Identities = 82/271 (30%), Positives = 121/271 (44%), Gaps = 14/271 (5%)

Query: 11  VIVLLQVVCSCPDKCYC--QSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAF 68
           V  LL V  SCP+ C C  + +  F DC+ + L E+P  LP    TL L  N+I  L   
Sbjct: 10  VWALLGVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRG 69

Query: 69  AFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELD 128
           AF  V  + +L L++N +  + PGA   L  L+ L+L+ N + S       +L  L+ L 
Sbjct: 70  AFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLK 129

Query: 129 LSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDNLWKCNCHL 188
           ++ N +  LP        +L  L +  N+L+ L     +++ ++  L L  N + C C L
Sbjct: 130 MNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGL 189

Query: 189 LGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELYQPCPLPAPDPVSSQAQWPG 248
           + L+ W           D I C SP   +G  + R+P     PC   AP  V   A+ P 
Sbjct: 190 VWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRLP---ALPC---APPSVHLSAEPPL 243

Query: 249 SAHGVVLRPPENHNAGERELLECELKPKPRP 279
            A G  LR      AG   +L C     P P
Sbjct: 244 EAPGTPLR------AGLAFVLHCIADGHPTP 268


>gi|194306618 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score =  104 bits (260), Expect = 1e-22
 Identities = 82/271 (30%), Positives = 121/271 (44%), Gaps = 14/271 (5%)

Query: 11  VIVLLQVVCSCPDKCYC--QSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAF 68
           V  LL V  SCP+ C C  + +  F DC+ + L E+P  LP    TL L  N+I  L   
Sbjct: 10  VWALLGVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRG 69

Query: 69  AFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELD 128
           AF  V  + +L L++N +  + PGA   L  L+ L+L+ N + S       +L  L+ L 
Sbjct: 70  AFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLK 129

Query: 129 LSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDNLWKCNCHL 188
           ++ N +  LP        +L  L +  N+L+ L     +++ ++  L L  N + C C L
Sbjct: 130 MNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGL 189

Query: 189 LGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELYQPCPLPAPDPVSSQAQWPG 248
           + L+ W           D I C SP   +G  + R+P     PC   AP  V   A+ P 
Sbjct: 190 VWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRLP---ALPC---APPSVHLSAEPPL 243

Query: 249 SAHGVVLRPPENHNAGERELLECELKPKPRP 279
            A G  LR      AG   +L C     P P
Sbjct: 244 EAPGTPLR------AGLAFVLHCIADGHPTP 268


>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
           sapiens]
          Length = 587

 Score =  103 bits (258), Expect = 2e-22
 Identities = 78/273 (28%), Positives = 125/273 (45%), Gaps = 15/273 (5%)

Query: 50  PQTRTLHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNS 109
           P  R L L DN I  LP   F ++  L  L LS N +S ++PGAF+GL  L+ L+L  N+
Sbjct: 299 PNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNA 358

Query: 110 LLSLESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRALLESM 169
           L  L+  +F  L  L+ + L +N +  LP ++      L  + +Q NQL+ L   + + +
Sbjct: 359 LQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHL 418

Query: 170 PSVRLLLLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELY 229
             +  L L DN W+C+  +L L+ WL     + G     +C SP   +G+ L+ I   + 
Sbjct: 419 GKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVA 478

Query: 230 QPC----PLPA-------PDPVSSQAQWPGSAHGVVLRPPENHNAGERELLECELKPKPR 278
            P      +P+       PD  S       S+   +  P E++     +L   ++     
Sbjct: 479 VPSVHVPEVPSYPETPWYPDTPSYPDTTSVSSTTELTSPVEDYT----DLTTIQVTDDRS 534

Query: 279 PANLRHAIATVIITGVVCGIVCLMMLAAAIYGC 311
              +  A + + I  +V GIV L    AA  GC
Sbjct: 535 VWGMTQAQSGLAIAAIVIGIVALACSLAACVGC 567



 Score = 73.6 bits (179), Expect = 2e-13
 Identities = 46/160 (28%), Positives = 73/160 (45%), Gaps = 1/160 (0%)

Query: 21  CPDKCYCQSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAFRSVPWLMTLN 80
           CP +C C  ++  V+C+   +  +P+ LP    +L + +  I  L    F ++  L+ L 
Sbjct: 31  CPSECTCSRASQ-VECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALR 89

Query: 81  LSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLSSNNISHLPTS 140
           +  N LS + PGAF  L  L+ L+L  N L  L   LF  L  L  L LSSN +  +  +
Sbjct: 90  IEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPA 149

Query: 141 LGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDN 180
                 NL  L +  N L+ +     + +  +  L L  N
Sbjct: 150 HFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKN 189



 Score = 72.8 bits (177), Expect = 4e-13
 Identities = 49/134 (36%), Positives = 71/134 (52%), Gaps = 1/134 (0%)

Query: 47  HLPPQTRTLHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLT 106
           HL   T+ L+L  N + H+    F+ +  L  L L  N L+++  G F GL +LQ L L 
Sbjct: 177 HLVGLTK-LNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQ 235

Query: 107 QNSLLSLESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRALL 166
           QN +  L   LFH+   L+ L LS+N+IS LP S+      L  L +  N L++L   + 
Sbjct: 236 QNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIF 295

Query: 167 ESMPSVRLLLLKDN 180
             MP++R L L DN
Sbjct: 296 GPMPNLRELWLYDN 309



 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 46/126 (36%), Positives = 60/126 (47%)

Query: 55  LHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLE 114
           L LQ NQI  L    F +   L  L LSNN +S L P  F  L  L  L L  NSL  L 
Sbjct: 232 LALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELS 291

Query: 115 SRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRALLESMPSVRL 174
             +F  +P LREL L  N+IS LP ++      L +L + +NQ+  +       +  +R 
Sbjct: 292 LGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRE 351

Query: 175 LLLKDN 180
           L L  N
Sbjct: 352 LSLHTN 357



 Score = 62.8 bits (151), Expect = 4e-10
 Identities = 37/128 (28%), Positives = 61/128 (47%)

Query: 53  RTLHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLS 112
           + L L +N++  +P   F  +  L  L L  N +  L+PG FH   +LQ L L+ N +  
Sbjct: 206 QVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQ 265

Query: 113 LESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRALLESMPSV 172
           L   +F  LPQL  L L  N++  L   +     NL  L +  N +  L   +  ++  +
Sbjct: 266 LPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQL 325

Query: 173 RLLLLKDN 180
           ++L+L  N
Sbjct: 326 QVLILSRN 333



 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 42/127 (33%), Positives = 61/127 (48%)

Query: 54  TLHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSL 113
           +L L  NQ+  +    F     L  L L  N L  +  GAF  L  L  LNL +NSL  +
Sbjct: 135 SLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHI 194

Query: 114 ESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRALLESMPSVR 173
             R+F  L  L+ L L  N ++ +P    +   NL  LA+QQNQ+  L   L  +  +++
Sbjct: 195 SPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQ 254

Query: 174 LLLLKDN 180
            L L +N
Sbjct: 255 RLYLSNN 261


>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
           sapiens]
          Length = 581

 Score =  103 bits (258), Expect = 2e-22
 Identities = 78/273 (28%), Positives = 125/273 (45%), Gaps = 15/273 (5%)

Query: 50  PQTRTLHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNS 109
           P  R L L DN I  LP   F ++  L  L LS N +S ++PGAF+GL  L+ L+L  N+
Sbjct: 293 PNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNA 352

Query: 110 LLSLESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRALLESM 169
           L  L+  +F  L  L+ + L +N +  LP ++      L  + +Q NQL+ L   + + +
Sbjct: 353 LQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHL 412

Query: 170 PSVRLLLLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELY 229
             +  L L DN W+C+  +L L+ WL     + G     +C SP   +G+ L+ I   + 
Sbjct: 413 GKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVA 472

Query: 230 QPC----PLPA-------PDPVSSQAQWPGSAHGVVLRPPENHNAGERELLECELKPKPR 278
            P      +P+       PD  S       S+   +  P E++     +L   ++     
Sbjct: 473 VPSVHVPEVPSYPETPWYPDTPSYPDTTSVSSTTELTSPVEDYT----DLTTIQVTDDRS 528

Query: 279 PANLRHAIATVIITGVVCGIVCLMMLAAAIYGC 311
              +  A + + I  +V GIV L    AA  GC
Sbjct: 529 VWGMTQAQSGLAIAAIVIGIVALACSLAACVGC 561



 Score = 73.6 bits (179), Expect = 2e-13
 Identities = 46/160 (28%), Positives = 73/160 (45%), Gaps = 1/160 (0%)

Query: 21  CPDKCYCQSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAFRSVPWLMTLN 80
           CP +C C  ++  V+C+   +  +P+ LP    +L + +  I  L    F ++  L+ L 
Sbjct: 25  CPSECTCSRASQ-VECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALR 83

Query: 81  LSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLSSNNISHLPTS 140
           +  N LS + PGAF  L  L+ L+L  N L  L   LF  L  L  L LSSN +  +  +
Sbjct: 84  IEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPA 143

Query: 141 LGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDN 180
                 NL  L +  N L+ +     + +  +  L L  N
Sbjct: 144 HFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKN 183



 Score = 72.8 bits (177), Expect = 4e-13
 Identities = 49/134 (36%), Positives = 71/134 (52%), Gaps = 1/134 (0%)

Query: 47  HLPPQTRTLHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLT 106
           HL   T+ L+L  N + H+    F+ +  L  L L  N L+++  G F GL +LQ L L 
Sbjct: 171 HLVGLTK-LNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQ 229

Query: 107 QNSLLSLESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRALL 166
           QN +  L   LFH+   L+ L LS+N+IS LP S+      L  L +  N L++L   + 
Sbjct: 230 QNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIF 289

Query: 167 ESMPSVRLLLLKDN 180
             MP++R L L DN
Sbjct: 290 GPMPNLRELWLYDN 303



 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 46/126 (36%), Positives = 60/126 (47%)

Query: 55  LHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLE 114
           L LQ NQI  L    F +   L  L LSNN +S L P  F  L  L  L L  NSL  L 
Sbjct: 226 LALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELS 285

Query: 115 SRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRALLESMPSVRL 174
             +F  +P LREL L  N+IS LP ++      L +L + +NQ+  +       +  +R 
Sbjct: 286 LGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRE 345

Query: 175 LLLKDN 180
           L L  N
Sbjct: 346 LSLHTN 351



 Score = 62.8 bits (151), Expect = 4e-10
 Identities = 37/128 (28%), Positives = 61/128 (47%)

Query: 53  RTLHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLS 112
           + L L +N++  +P   F  +  L  L L  N +  L+PG FH   +LQ L L+ N +  
Sbjct: 200 QVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQ 259

Query: 113 LESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRALLESMPSV 172
           L   +F  LPQL  L L  N++  L   +     NL  L +  N +  L   +  ++  +
Sbjct: 260 LPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQL 319

Query: 173 RLLLLKDN 180
           ++L+L  N
Sbjct: 320 QVLILSRN 327



 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 42/127 (33%), Positives = 61/127 (48%)

Query: 54  TLHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSL 113
           +L L  NQ+  +    F     L  L L  N L  +  GAF  L  L  LNL +NSL  +
Sbjct: 129 SLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHI 188

Query: 114 ESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRALLESMPSVR 173
             R+F  L  L+ L L  N ++ +P    +   NL  LA+QQNQ+  L   L  +  +++
Sbjct: 189 SPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQ 248

Query: 174 LLLLKDN 180
            L L +N
Sbjct: 249 RLYLSNN 255


>gi|40217825 slit and trk like 6 [Homo sapiens]
          Length = 841

 Score =  102 bits (255), Expect = 4e-22
 Identities = 81/262 (30%), Positives = 120/262 (45%), Gaps = 37/262 (14%)

Query: 20  SCPDKCYCQSS--TNFVDCSQQGLAEIPSHLPPQTR------------------------ 53
           SC   C C+    T  ++C  +G+  +     P +R                        
Sbjct: 30  SCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLHTNDFSGLTN 89

Query: 54  --TLHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLL 111
             ++HL  N I  +   AF  +  L  L++++NSL  L    FHGL++L+ L    N + 
Sbjct: 90  AISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNFIT 149

Query: 112 SLESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDR-ALLESMP 170
            +E   F  L +L+ L L+ N I  LP ++   +  LT L ++ NQLQ L     LE + 
Sbjct: 150 VIEPSAFSKLNRLKVLILNDNAIESLPPNIFR-FVPLTHLDLRGNQLQTLPYVGFLEHIG 208

Query: 171 SVRLLLLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELYQ 230
            +  L L+DN W CNC LL LK WLE    +  + D ++C SP  +KG  L R+  E   
Sbjct: 209 RILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGD-VVCNSPPFFKGSILSRLKKE--S 265

Query: 231 PCPLPAPDPVSSQAQWP-GSAH 251
            CP P   PV  + + P GS H
Sbjct: 266 ICPTP---PVYEEHEDPSGSLH 284



 Score = 89.0 bits (219), Expect = 6e-18
 Identities = 57/178 (32%), Positives = 100/178 (56%), Gaps = 3/178 (1%)

Query: 55  LHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLE 114
           LHL +N+I  L   +F ++  L  L L+ N L+ L+ G F GL +L+ L L  N++  + 
Sbjct: 392 LHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIKEIL 451

Query: 115 SRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRA-LLESMPSVR 173
              F+ +P+L+ L L++N +  LP  +  +   LT + ++ NQ   L  + +L+ +  + 
Sbjct: 452 PGTFNPMPKLKVLYLNNNLLQVLPPHI-FSGVPLTKVNLKTNQFTHLPVSNILDDLDLLT 510

Query: 174 LLLLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELYQP 231
            + L+DN W C+C L+GL+ W++K + K  +TD I+C SP     K+L  +  E+  P
Sbjct: 511 QIDLEDNPWDCSCDLVGLQQWIQK-LSKNTVTDDILCTSPGHLDKKELKALNSEILCP 567


>gi|40217817 slit and trk like 1 protein [Homo sapiens]
          Length = 696

 Score =  100 bits (250), Expect = 1e-21
 Identities = 72/231 (31%), Positives = 112/231 (48%), Gaps = 26/231 (11%)

Query: 54  TLHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSL 113
           +LH+++N +H +   AF  +  +  L+++NN + +     F GL  L+ L    N L  +
Sbjct: 86  SLHMENNGLHEIVPGAFLGLQLVKRLHINNNKIKSFRKQTFLGLDDLEYLQADFNLLRDI 145

Query: 114 ESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLD-RALLESMPSV 172
           +   F  L +L  L L+ N IS LP ++ + +  +T L ++ N+L+ L    +LE +P +
Sbjct: 146 DPGAFQDLNKLEVLILNDNLISTLPANVFQ-YVPITHLDLRGNRLKTLPYEEVLEQIPGI 204

Query: 173 RLLLLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKGKDL----------- 221
             +LL+DN W C C LL LK WLE  + K  L   ++CE+P   +GKDL           
Sbjct: 205 AEILLEDNPWDCTCDLLSLKEWLEN-IPKNALIGRVVCEAPTRLQGKDLNETTEQDLCPL 263

Query: 222 -------LRIP---HELYQPCPLPAPDPVSSQAQ--WPGSAHGVVLRPPEN 260
                  L  P    E + P PLP P   + Q     PGSA     + P N
Sbjct: 264 KNRVDSSLPAPPAQEETFAPGPLPTPFKTNGQEDHATPGSAPNGGTKIPGN 314



 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 61/243 (25%), Positives = 115/243 (47%), Gaps = 34/243 (13%)

Query: 21  CPDKCYCQ---SSTNFVDCSQQGLAEIPSHLPP--QTRTLHLQDNQIHHLPAFAFRSVPW 75
           CP  C C     S   ++C+ + ++ +    P     + L L+DN+IH +    F     
Sbjct: 341 CPGGCSCDHIPGSGLKMNCNNRNVSSLADLKPKLSNVQELFLRDNKIHSIRKSHFVDYKN 400

Query: 76  LMTLNLSNNS------------------------LSNLAPGAFHGLQHLQVLNLTQNSLL 111
           L+ L+L NN+                        L  L+   F GLQ+L+ LN+  N++ 
Sbjct: 401 LILLDLGNNNIATVENNTFKNLLDLRWLYMDSNYLDTLSREKFAGLQNLEYLNVEYNAIQ 460

Query: 112 SLESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRA-LLESMP 170
            +    F+++P+LR L L++N +  LP  +     +L+ L++  N    L  A +L+ + 
Sbjct: 461 LILPGTFNAMPKLRILILNNNLLRSLPVDV-FAGVSLSKLSLHNNYFMYLPVAGVLDQLT 519

Query: 171 SVRLLLLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELYQ 230
           S+  + L  N W+C+C ++  K W E+   +  ++D + CE+P  +  KD + + ++  +
Sbjct: 520 SIIQIDLHGNPWECSCTIVPFKQWAERLGSEVLMSD-LKCETPVNFFRKDFMLLSND--E 576

Query: 231 PCP 233
            CP
Sbjct: 577 ICP 579


>gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]
          Length = 420

 Score = 97.8 bits (242), Expect = 1e-20
 Identities = 83/303 (27%), Positives = 116/303 (38%), Gaps = 74/303 (24%)

Query: 20  SCPDKCYCQSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAFRS---VPWL 76
           SCP  C C SS   V C     + +P  LPP T+ L LQ+N I  L    F S     WL
Sbjct: 30  SCPMLCTCYSSPPTVSCQANNFSSVPLSLPPSTQRLFLQNNLIRTLRPGTFGSNLLTLWL 89

Query: 77  MTLNLS--------------------NNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESR 116
            + NLS                    N  L +L P  F GL+ LQ L+L +  L SL   
Sbjct: 90  FSNNLSTIYPGTFRHLQALEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQLSSLPGN 149

Query: 117 LFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQ-----------QLDRAL 165
           +F  L  L+ L L  N++ HL   L     NL+ L +  N+L+            LDR L
Sbjct: 150 IFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRLL 209

Query: 166 LE-------------------------------------SMPSVRLLLLKDNLWKCNCHL 188
           L                                       +PS+  L L  N W C+C  
Sbjct: 210 LHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNANPWACDCRA 269

Query: 189 LGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELYQPCPLPAPDPVSSQAQWPG 248
             L  W ++       +  + C +P   +G+DL  +    +Q CP  AP    S+A+   
Sbjct: 270 RPLWAWFQRARVS---SSDVTCATPPERQGRDLRALREADFQACPPAAPTRPGSRARGNS 326

Query: 249 SAH 251
           S++
Sbjct: 327 SSN 329


>gi|40217820 slit and trk like 3 protein [Homo sapiens]
          Length = 977

 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 82/260 (31%), Positives = 126/260 (48%), Gaps = 34/260 (13%)

Query: 21  CPDKCYCQ--SSTNFVDCSQQGLAEIPSHLPPQTRT--LHLQDNQIHHLPAFAFRSVPWL 76
           C D CYC+   S   + C  +G   I       +R   L+LQ N +  L   +F  +   
Sbjct: 44  CFDPCYCEVKESLFHIHCDSKGFTNISQITEFWSRPFKLYLQRNSMRKLYTNSFLHLNNA 103

Query: 77  MTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSL------------------------LS 112
           +++NL NN+L ++  GAF+GL+ L+ L L +N L                          
Sbjct: 104 VSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFRNDTFLGLESLEYLQADYNVIKR 163

Query: 113 LESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQL-DRALLESM-P 170
           +ES  F +L +LR L L+ N I  LPT+L +   +LT L ++ N+L+ L  R +L+ +  
Sbjct: 164 IESGAFRNLSKLRVLILNDNLIPMLPTNLFKA-VSLTHLDLRGNRLKVLFYRGMLDHIGR 222

Query: 171 SVRLLLLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELYQ 230
           S+  L L++N W C C ++ LK WLE+  Y   L   I CE+P  + GKDL  I     +
Sbjct: 223 SLMELQLEENPWNCTCEIVQLKSWLERIPYT-ALVGDITCETPFHFHGKDLREI--RKTE 279

Query: 231 PCPLPAPDPVSSQAQWPGSA 250
            CPL +   V +    P S+
Sbjct: 280 LCPLLSDSEVEASLGIPHSS 299



 Score = 89.7 bits (221), Expect = 3e-18
 Identities = 72/262 (27%), Positives = 113/262 (43%), Gaps = 34/262 (12%)

Query: 21  CPDKCYCQSSTN----FVDCSQQGLAEIPSHLPPQTRT---------------------- 54
           CP  C C    N     V+C ++G   I   LP                           
Sbjct: 373 CPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSDFWNFS 432

Query: 55  ----LHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSL 110
               LHL +N+I ++   AF ++P L +L L+ N +  L PG F GLQ L  L    N +
Sbjct: 433 SLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVI 492

Query: 111 LSLESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRA-LLESM 169
             ++   F  +P L+ L L++N +  LPT       +L  L +++N    L  A +LE +
Sbjct: 493 REIQPAAFSLMPNLKLLFLNNNLLRTLPTD-AFAGTSLARLNLRKNYFLYLPVAGVLEHL 551

Query: 170 PSVRLLLLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELY 229
            ++  + L +N W C C L+  K W+E  +    +   ++C SP+    +D+  I  E+ 
Sbjct: 552 NAIVQIDLNENPWDCTCDLVPFKQWIET-ISSVSVVGDVLCRSPENLTHRDVRTIELEVL 610

Query: 230 QPCPLPAPDPVSSQAQWPGSAH 251
            P  L       S AQ PG +H
Sbjct: 611 CPEMLHVAPAGESPAQ-PGDSH 631


>gi|153251229 chondroadherin precursor [Homo sapiens]
          Length = 359

 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 58/176 (32%), Positives = 92/176 (52%), Gaps = 1/176 (0%)

Query: 5   LLLFSSVIVLLQVVCSCPDKCYCQSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHH 64
           LL    +  LL  + +CP  C+C S    V C + GL +IP  +  +T+ L+LQ N    
Sbjct: 7   LLSLGLLAGLLPALAACPQNCHCHSDLQHVICDKVGLQKIPK-VSEKTKLLNLQRNNFPV 65

Query: 65  LPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQL 124
           L A +FR++P L++L+L +  +  +A GAF GL+ L  L L+ N +  L +  F  L +L
Sbjct: 66  LAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTEL 125

Query: 125 RELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDN 180
             L L  N ++ LP  L     NL IL +  N++++L     +    +R L L +N
Sbjct: 126 TYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSEN 181



 Score = 76.6 bits (187), Expect = 3e-14
 Identities = 62/204 (30%), Positives = 89/204 (43%), Gaps = 29/204 (14%)

Query: 55  LHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLE 114
           L L +N+I  L A AF+    L  L LS N+LS+L PGA   +++L   ++ +N L S  
Sbjct: 152 LQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQPGALDDVENLAKFHVDRNQLSSYP 211

Query: 115 SRLFHSLPQLRELDLSSNNISHLP----TSLGETWENL-------------TILAVQQNQ 157
           S     L  + EL LS N +  +P     S G   E L               L V   +
Sbjct: 212 SAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNTNLEKFSDGAFLGVTTLK 271

Query: 158 LQQLDRALLESMP------SVRLLLLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICE 211
              L+   L  +P      S+  L L +N WKC C L GL+ WLE    +   T    C 
Sbjct: 272 HVHLENNRLNQLPSNFPFDSLETLALTNNPWKCTCQLRGLRRWLEAKASRPDAT----CA 327

Query: 212 SPDTWKGKDLLRIPHELYQPCPLP 235
           SP  +KG+ +     + ++ C  P
Sbjct: 328 SPAKFKGQHIR--DTDAFRSCKFP 349


>gi|239752702 PREDICTED: leucine rich repeat containing 38, partial
           [Homo sapiens]
          Length = 254

 Score = 97.1 bits (240), Expect = 2e-20
 Identities = 64/200 (32%), Positives = 97/200 (48%), Gaps = 3/200 (1%)

Query: 35  DCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAF 94
           DC  +GL  +P   P   R L +  N+I  +P   F     L+ L+  NNSL +L  G F
Sbjct: 1   DCRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTF 60

Query: 95  HGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQ 154
            G   L  L+L+ N+L  L +  F S  +L +L L++NN+  +     ET E+L +L + 
Sbjct: 61  SGSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELN 120

Query: 155 QNQLQQLDRALLESMPSVRLLLLKDNLWKCNCHLLGLKLWLEKFVYK--GGLTDGIICES 212
            N L+ L  A L ++P++R L L  N W C+C    L  W+++   K   GL D I C  
Sbjct: 121 DNNLRSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGL-DEIQCSL 179

Query: 213 PDTWKGKDLLRIPHELYQPC 232
           P   +   L  +    +  C
Sbjct: 180 PMESRRISLRELSEASFSEC 199


>gi|61966761 leucine rich repeat containing 26 [Homo sapiens]
          Length = 334

 Score = 96.7 bits (239), Expect = 3e-20
 Identities = 68/216 (31%), Positives = 96/216 (44%), Gaps = 3/216 (1%)

Query: 21  CPDKCYCQSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAFRSVPWLMTLN 80
           CP+ C C        CS   L  +P  L  + R L L  N++  LP  AF     L  L+
Sbjct: 43  CPEVCTCVPG-GLASCSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLD 101

Query: 81  LSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLSSNNISHL-PT 139
           L  N L ++   AF GL  LQ+L+L+ N L +L    F  L  LR L L+ N ++ L P 
Sbjct: 102 LRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPA 161

Query: 140 SLGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDNLWKCNCHLLGLKLWLEKFV 199
           +LG     L  L++Q N+L  L   LL  +P++  L L+ N W C C L  L  WL +  
Sbjct: 162 ALGAL-PLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRHP 220

Query: 200 YKGGLTDGIICESPDTWKGKDLLRIPHELYQPCPLP 235
                 + ++C  P       L       +  C  P
Sbjct: 221 LPASEAETVLCVWPGRLTLSPLTAFSDAAFSHCAQP 256


>gi|40217823 SLIT and NTRK-like family, member 5 [Homo sapiens]
          Length = 958

 Score = 96.3 bits (238), Expect = 4e-20
 Identities = 76/272 (27%), Positives = 118/272 (43%), Gaps = 33/272 (12%)

Query: 21  CPDKCYCQSSTNF--VDCSQQGLAEIPSHLPPQ--------------------------T 52
           C + C C+       V C  +G+  +    PP+                           
Sbjct: 48  CDNACPCEEKDGILTVSCENRGIISLSEISPPRFPIYHLLLSGNLLNRLYPNEFVNYTGA 107

Query: 53  RTLHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLS 112
             LHL  N I  +   AF  +  L  L+L+NN L  L    F GL++L+ L +  N +  
Sbjct: 108 SILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISV 167

Query: 113 LESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDR-ALLESMPS 171
           +E   F  L  L+ L L+ N +S LP +L   +  LT L ++ N+L+ L    LL+ M  
Sbjct: 168 IEPNAFGKLHLLQVLILNDNLLSSLPNNLFR-FVPLTHLDLRGNRLKLLPYVGLLQHMDK 226

Query: 172 VRLLLLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELYQP 231
           V  L L++N W C+C L+ LK WL+   Y   L   ++CE+P    G+DL  +  +  + 
Sbjct: 227 VVELQLEENPWNCSCELISLKDWLDSISY-SALVGDVVCETPFRLHGRDLDEVSKQ--EL 283

Query: 232 CPLPAPDPVSSQAQWPGSAHGVVLRPPENHNA 263
           CP         + Q P S  G +   P + N+
Sbjct: 284 CPRRLISDYEMRPQTPLSTTGYLHTTPASVNS 315



 Score = 93.6 bits (231), Expect = 2e-19
 Identities = 63/196 (32%), Positives = 103/196 (52%), Gaps = 11/196 (5%)

Query: 55  LHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLE 114
           LHL +N+I  +   AF  +  L  L L+ N +  L+P  F+GLQ LQ L L  N +  ++
Sbjct: 438 LHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPELFYGLQSLQYLFLQYNLIREIQ 497

Query: 115 SRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILA--VQQNQLQQLD-RALLESMPS 171
           S  F  +P L+ L L++N +  +P+ +   +  LT+L   ++ N    L    +L+ + S
Sbjct: 498 SGTFDPVPNLQLLFLNNNLLQAMPSGV---FSGLTLLRLNLRSNHFTSLPVSGVLDQLKS 554

Query: 172 VRLLLLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHEL--- 228
           +  + L DN W C C ++G+KLW+E+ +  G L D +IC++P  +   D+  I  EL   
Sbjct: 555 LIQIDLHDNPWDCTCDIVGMKLWVEQ-LKVGVLVDEVICKAPKKFAETDMRSIKSELLCP 613

Query: 229 -YQPCPLPAPDPVSSQ 243
            Y    +  P P S Q
Sbjct: 614 DYSDVVVSTPTPSSIQ 629


>gi|109150416 peroxidasin [Homo sapiens]
          Length = 1479

 Score = 95.5 bits (236), Expect = 6e-20
 Identities = 67/220 (30%), Positives = 103/220 (46%), Gaps = 4/220 (1%)

Query: 21  CPDKCYCQSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAFRSVPWLMTLN 80
           CP +C C  +T  V C    L  +P+ + PQT  L L+ N+I  +   AFR +  L TL 
Sbjct: 36  CPSRCLCFRTT--VRCMHLLLEAVPA-VAPQTSILDLRFNRIREIQPGAFRRLRNLNTLL 92

Query: 81  LSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLSSNNISHLPTS 140
           L+NN +  +  GAF  L++L+ L L +N + S++ + F  L  L +L L  N I  L   
Sbjct: 93  LNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQIETLDPD 152

Query: 141 LGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDNLWKCNCHLLGLKLWLEKFVY 200
             +    L  L +  N++  L       + S++ L L  N   C+C +L L   L+ +  
Sbjct: 153 SFQHLPKLERLFLHNNRITHLVPGTFNHLESMKRLRLDSNTLHCDCEILWLADLLKTYAE 212

Query: 201 KGGLTDGIICESPDTWKGKDLLRI-PHELYQPCPLPAPDP 239
            G      ICE P   +G+ +  I P EL    P    +P
Sbjct: 213 SGNAQAAAICEYPRRIQGRSVATITPEELNCERPRITSEP 252


>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
          Length = 545

 Score = 94.7 bits (234), Expect = 1e-19
 Identities = 62/193 (32%), Positives = 102/193 (52%), Gaps = 3/193 (1%)

Query: 55  LHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLE 114
           L LQ N +  LPA  F   P L+ L+L++N L  +A G F  L +L+ L L+ N++  L 
Sbjct: 270 LSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLP 329

Query: 115 SRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRALLESMPSVRL 174
           + +F  L +L +L L SNN++ L  +L +    L +L++ +NQL  L   + ++  ++  
Sbjct: 330 AGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFN 389

Query: 175 LLLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELYQPCPL 234
           L L  N W+C+CHL  L  WL+++  +  L     C  P   KG+ ++   +E    CP+
Sbjct: 390 LALHGNPWQCDCHLAYLFNWLQQYTDR-LLNIQTYCAGPAYLKGQ-VVPALNEKQLVCPV 447

Query: 235 PAPDPVSSQAQWP 247
              D +  Q  WP
Sbjct: 448 -TRDHLGFQVTWP 459



 Score = 91.3 bits (225), Expect = 1e-18
 Identities = 60/181 (33%), Positives = 90/181 (49%), Gaps = 2/181 (1%)

Query: 1   MKGELLLFSSVIVLLQVVCSCPDKCYCQSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDN 60
           + G  LL++S+++L +    CP  C C     F  CS + LA +P  +PP T+ +   + 
Sbjct: 2   LPGAWLLWTSLLLLARPAQPCPMGCDCFVQEVF--CSDEELATVPLDIPPYTKNIIFVET 59

Query: 61  QIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHS 120
               L   AF S P L  +   N  L    P AF GL  L+ L +T +S L+L + +F +
Sbjct: 60  SFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSN 119

Query: 121 LPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDN 180
           L  L +L L+ N +  LP  L +    L  L +Q NQLQ L R L + +  ++ L L  N
Sbjct: 120 LTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQN 179

Query: 181 L 181
           L
Sbjct: 180 L 180



 Score = 79.3 bits (194), Expect = 5e-15
 Identities = 54/150 (36%), Positives = 79/150 (52%), Gaps = 4/150 (2%)

Query: 32  NFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAP 91
           N ++   +GL +   HL     +LHLQ NQ+  LP   F+ +  L TLNL+ N L+ L  
Sbjct: 131 NMLEALPEGLFQ---HLAA-LESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPE 186

Query: 92  GAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTIL 151
             FH L  LQ L L+ N+L  L   +F  L  L+EL L SNNIS LP  +      L  L
Sbjct: 187 ELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERL 246

Query: 152 AVQQNQLQQLDRALLESMPSVRLLLLKDNL 181
            +Q+N +  L  ++  S+ ++  L L+ N+
Sbjct: 247 WLQRNAITHLPLSIFASLGNLTFLSLQWNM 276



 Score = 75.1 bits (183), Expect = 9e-14
 Identities = 50/128 (39%), Positives = 66/128 (51%)

Query: 53  RTLHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLS 112
           +TL+L  N +  LP   F  +  L TL LSNN+LS L  G F  L  LQ L L  N++  
Sbjct: 172 KTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISE 231

Query: 113 LESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRALLESMPSV 172
           L  ++F  L  L  L L  N I+HLP S+  +  NLT L++Q N L+ L   L    P +
Sbjct: 232 LPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCL 291

Query: 173 RLLLLKDN 180
             L L  N
Sbjct: 292 VGLSLTHN 299



 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 42/126 (33%), Positives = 60/126 (47%)

Query: 55  LHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLE 114
           L L  N +  LP   F+ +  L +L+L  N L  L    F  L HL+ LNL QN L  L 
Sbjct: 126 LTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLP 185

Query: 115 SRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRALLESMPSVRL 174
             LFH L  L+ L LS+N +S LP  +     +L  L +  N + +L   +   +  +  
Sbjct: 186 EELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLER 245

Query: 175 LLLKDN 180
           L L+ N
Sbjct: 246 LWLQRN 251


>gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo
           sapiens]
          Length = 516

 Score = 94.0 bits (232), Expect = 2e-19
 Identities = 62/198 (31%), Positives = 92/198 (46%), Gaps = 26/198 (13%)

Query: 53  RTLHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLS 112
           +TLHL+ N +  +P   F     L  L+LS N L +LA   F GL  L+ L+L  N L  
Sbjct: 160 QTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTK 219

Query: 113 LESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRALLESMPSV 172
           +    F  L  L  L L  N IS+L   +  TW  L  L +  N+++ +D  + E+MP++
Sbjct: 220 INFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNL 279

Query: 173 RLLL------------------------LKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGI 208
           ++LL                        L  NLW+C+  +  L  WL  F  +G     I
Sbjct: 280 KILLMDNNKLNSLDSKILNSLRSLTTVGLSGNLWECSARICALASWLGSF--QGRWEHSI 337

Query: 209 ICESPDTWKGKDLLRIPH 226
           +C SPD  +G+D+L   H
Sbjct: 338 LCHSPDHTQGEDILDAVH 355



 Score = 72.4 bits (176), Expect = 6e-13
 Identities = 54/181 (29%), Positives = 80/181 (44%), Gaps = 3/181 (1%)

Query: 1   MKGELLLFSSVIVLLQVV-CSCPDKCYCQSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQD 59
           M   +   S V+ +L  +  +CP KC C+    +  C  QG   +P+     +  L L+ 
Sbjct: 13  MLAAIYAMSMVLKMLPALGMACPPKCRCEKLLFY--CDSQGFHSVPNATDKGSLGLSLRH 70

Query: 60  NQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFH 119
           N I  L    F S   L  L+L +N +S +   AF GL  L+ L L+ N +  L +  F 
Sbjct: 71  NHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFT 130

Query: 120 SLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKD 179
            L  L+ LDLS N +S L   L      L  L ++ N L+ +   L     S+  L L  
Sbjct: 131 QLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLST 190

Query: 180 N 180
           N
Sbjct: 191 N 191


>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
          Length = 811

 Score = 94.0 bits (232), Expect = 2e-19
 Identities = 90/296 (30%), Positives = 132/296 (44%), Gaps = 19/296 (6%)

Query: 54  TLHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSL 113
           +L L  N + HL    F+ +P L  L+L  N L++LAP AF GL+ L+ L L  N L  L
Sbjct: 233 SLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQL 292

Query: 114 ESRLFHSLPQLRELDLSSNNISHL-PTSLGETWENLTILAVQQNQLQQLDRALLESMPSV 172
            + L   L  L  LDLS N +S L P + G     L  L+++ N L  L   +  + P++
Sbjct: 293 PTALLEPLHSLEALDLSGNELSALHPATFGHLGR-LRELSLRNNALSALSGDIFAASPAL 351

Query: 173 RLLLLKDNLWKCNCHLLGLKLWLEKFVYKGG-LTDGIICESPDTWKGKDLLRIPHELYQP 231
             L L  N W C+C L GLK W+  +  +G  LT  + C  P   +GK L  +  +  Q 
Sbjct: 352 YRLDLDGNGWTCDCRLRGLKRWMGDWHSQGRLLTVFVQCRHPPALRGKYLDYLDDQQLQN 411

Query: 232 CPLPAPDPVSS-----QAQWPGSAHGVVLRPPENHNAGERELLECELKPKPRPANLRHAI 286
                P P +S     + Q   +A G  + PP    AG  E    EL P+P+       +
Sbjct: 412 GSCADPSPSASLTADRRRQPLPTAAGEEMTPP----AGLAE----ELPPQPQLQQQGRFL 463

Query: 287 ATVIITGVVCGIV---CLMMLAAAIYGCTYAAITAQYHGGPLAQTNDPGKVEEKER 339
           A V   G    +V     + L+    G    + +     GP  Q+ D  K  ++ R
Sbjct: 464 AGVAWDGAARELVGNRSALRLSRRGPGLQQPSPSVAAAAGPAPQSLDLHKKPQRGR 519



 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 59/206 (28%), Positives = 83/206 (40%), Gaps = 40/206 (19%)

Query: 14  LLQVVCSC-----------PDKCYCQSSTNFVDCSQQGLAEIP--SHLPP---------- 50
           LL VVC C           P++C CQ   + + C+ +GL  +P  S LP           
Sbjct: 9   LLLVVCGCLALPPLAEPVCPERCDCQHPQHLL-CTNRGLRVVPKTSSLPSPHDVLTYSLG 67

Query: 51  ----------------QTRTLHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAF 94
                           Q R L LQ NQI  L    F  +  L  L L NN L  LAPG  
Sbjct: 68  GNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTL 127

Query: 95  HGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQ 154
             L+ L++L    N +  L    F  L  L +L L  N +  LP ++     NL  L ++
Sbjct: 128 APLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLE 187

Query: 155 QNQLQQLDRALLESMPSVRLLLLKDN 180
            N+++ L +     +  +R L L  N
Sbjct: 188 SNRIRFLGKNAFAQLGKLRFLNLSAN 213


>gi|221136985 SLIT and NTRK-like family, member 2 [Homo sapiens]
          Length = 845

 Score = 93.2 bits (230), Expect = 3e-19
 Identities = 78/287 (27%), Positives = 124/287 (43%), Gaps = 36/287 (12%)

Query: 21  CPDKCYCQSSTNF--VDCSQQGLAEIPSHLPPQTR------------------------- 53
           C  +C C+   N   ++C  +G   +    PPQ R                         
Sbjct: 29  CKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRIYQLFLNGNLLTRLYPNEFVNYSNA 88

Query: 54  -TLHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLS 112
            TLHL +N +  +   AF  +  L  L+L+NN L  L    F GL+ L+ L    N + +
Sbjct: 89  VTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILREDTFLGLESLEYLQADYNYISA 148

Query: 113 LESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRA-LLESMPS 171
           +E+  F  L +L+ L L+ N +  LP+++   +  LT L ++ N+L+ +  A +LE +  
Sbjct: 149 IEAGAFSKLNKLKVLILNDNLLLSLPSNVFR-FVLLTHLDLRGNRLKVMPFAGVLEHIGG 207

Query: 172 VRLLLLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELYQP 231
           +  + L++N W C C LL LK WL+      G    I+CE+P    GKD+ ++  +    
Sbjct: 208 IMEIQLEENPWNCTCDLLPLKAWLDTITVFVG---EIVCETPFRLHGKDVTQLTRQ--DL 262

Query: 232 CPLPAPDPVSSQAQWPGSAHGVVLRPPENHNAGERELLECELKPKPR 278
           CP  +    SSQ       H   L P  N         +    PK R
Sbjct: 263 CPRKSASD-SSQRGSHADTHVQRLSPTMNPALNPTRAPKASRPPKMR 308



 Score = 83.2 bits (204), Expect = 3e-16
 Identities = 87/325 (26%), Positives = 134/325 (41%), Gaps = 52/325 (16%)

Query: 17  VVCSCPDKCYC--QSSTNF--VDCSQQGLAEIPSHLPPQTRT------------------ 54
           V  +CP  C C  QSS N   V+C ++    I    P  T                    
Sbjct: 336 VPLTCPSSCVCTSQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDL 395

Query: 55  --------LHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLT 106
                   LHL +N+I  +   AF ++  L  L L+ N L  L P  F GLQ LQ L L 
Sbjct: 396 LEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLE 455

Query: 107 QNSLLSLESRLFHSLPQLRELDLSSNNISHLPTSL-GETWENLTILAVQQNQLQQLD-RA 164
            N +  ++   F +L  L+ L L++N +  LP ++ G T   LT L ++ N    L  + 
Sbjct: 456 YNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNIFGGT--ALTRLNLRNNHFSHLPVKG 513

Query: 165 LLESMPSVRLLLLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRI 224
           +L+ +P+   + L++N W C C ++GLK W E       + + + CESP    G+ L  +
Sbjct: 514 VLDQLPAFIQIDLQENPWDCTCDIMGLKDWTE-HANSPVIINEVTCESPAKHAGEILKFL 572

Query: 225 PHELYQPCPLPAPDPVSSQAQWPGSAHGVVLRPPENHNAGERELLECELKPKPRPANLRH 284
             E    CP             P  + G VL    NHN      L   + P   P     
Sbjct: 573 GREAI--CP-----------DSPNLSDGTVL--SMNHNTDTPRSL--SVSPSSYPELHTE 615

Query: 285 AIATVIITGVVCGIVCLMMLAAAIY 309
              +V+I G++   +  +   A ++
Sbjct: 616 VPLSVLILGLLVVFILSVCFGAGLF 640


>gi|221136981 SLIT and NTRK-like family, member 2 [Homo sapiens]
          Length = 845

 Score = 93.2 bits (230), Expect = 3e-19
 Identities = 78/287 (27%), Positives = 124/287 (43%), Gaps = 36/287 (12%)

Query: 21  CPDKCYCQSSTNF--VDCSQQGLAEIPSHLPPQTR------------------------- 53
           C  +C C+   N   ++C  +G   +    PPQ R                         
Sbjct: 29  CKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRIYQLFLNGNLLTRLYPNEFVNYSNA 88

Query: 54  -TLHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLS 112
            TLHL +N +  +   AF  +  L  L+L+NN L  L    F GL+ L+ L    N + +
Sbjct: 89  VTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILREDTFLGLESLEYLQADYNYISA 148

Query: 113 LESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRA-LLESMPS 171
           +E+  F  L +L+ L L+ N +  LP+++   +  LT L ++ N+L+ +  A +LE +  
Sbjct: 149 IEAGAFSKLNKLKVLILNDNLLLSLPSNVFR-FVLLTHLDLRGNRLKVMPFAGVLEHIGG 207

Query: 172 VRLLLLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELYQP 231
           +  + L++N W C C LL LK WL+      G    I+CE+P    GKD+ ++  +    
Sbjct: 208 IMEIQLEENPWNCTCDLLPLKAWLDTITVFVG---EIVCETPFRLHGKDVTQLTRQ--DL 262

Query: 232 CPLPAPDPVSSQAQWPGSAHGVVLRPPENHNAGERELLECELKPKPR 278
           CP  +    SSQ       H   L P  N         +    PK R
Sbjct: 263 CPRKSASD-SSQRGSHADTHVQRLSPTMNPALNPTRAPKASRPPKMR 308



 Score = 83.2 bits (204), Expect = 3e-16
 Identities = 87/325 (26%), Positives = 134/325 (41%), Gaps = 52/325 (16%)

Query: 17  VVCSCPDKCYC--QSSTNF--VDCSQQGLAEIPSHLPPQTRT------------------ 54
           V  +CP  C C  QSS N   V+C ++    I    P  T                    
Sbjct: 336 VPLTCPSSCVCTSQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDL 395

Query: 55  --------LHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLT 106
                   LHL +N+I  +   AF ++  L  L L+ N L  L P  F GLQ LQ L L 
Sbjct: 396 LEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLE 455

Query: 107 QNSLLSLESRLFHSLPQLRELDLSSNNISHLPTSL-GETWENLTILAVQQNQLQQLD-RA 164
            N +  ++   F +L  L+ L L++N +  LP ++ G T   LT L ++ N    L  + 
Sbjct: 456 YNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNIFGGT--ALTRLNLRNNHFSHLPVKG 513

Query: 165 LLESMPSVRLLLLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRI 224
           +L+ +P+   + L++N W C C ++GLK W E       + + + CESP    G+ L  +
Sbjct: 514 VLDQLPAFIQIDLQENPWDCTCDIMGLKDWTE-HANSPVIINEVTCESPAKHAGEILKFL 572

Query: 225 PHELYQPCPLPAPDPVSSQAQWPGSAHGVVLRPPENHNAGERELLECELKPKPRPANLRH 284
             E    CP             P  + G VL    NHN      L   + P   P     
Sbjct: 573 GREAI--CP-----------DSPNLSDGTVL--SMNHNTDTPRSL--SVSPSSYPELHTE 615

Query: 285 AIATVIITGVVCGIVCLMMLAAAIY 309
              +V+I G++   +  +   A ++
Sbjct: 616 VPLSVLILGLLVVFILSVCFGAGLF 640


>gi|221136977 SLIT and NTRK-like family, member 2 [Homo sapiens]
          Length = 845

 Score = 93.2 bits (230), Expect = 3e-19
 Identities = 78/287 (27%), Positives = 124/287 (43%), Gaps = 36/287 (12%)

Query: 21  CPDKCYCQSSTNF--VDCSQQGLAEIPSHLPPQTR------------------------- 53
           C  +C C+   N   ++C  +G   +    PPQ R                         
Sbjct: 29  CKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRIYQLFLNGNLLTRLYPNEFVNYSNA 88

Query: 54  -TLHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLS 112
            TLHL +N +  +   AF  +  L  L+L+NN L  L    F GL+ L+ L    N + +
Sbjct: 89  VTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILREDTFLGLESLEYLQADYNYISA 148

Query: 113 LESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRA-LLESMPS 171
           +E+  F  L +L+ L L+ N +  LP+++   +  LT L ++ N+L+ +  A +LE +  
Sbjct: 149 IEAGAFSKLNKLKVLILNDNLLLSLPSNVFR-FVLLTHLDLRGNRLKVMPFAGVLEHIGG 207

Query: 172 VRLLLLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELYQP 231
           +  + L++N W C C LL LK WL+      G    I+CE+P    GKD+ ++  +    
Sbjct: 208 IMEIQLEENPWNCTCDLLPLKAWLDTITVFVG---EIVCETPFRLHGKDVTQLTRQ--DL 262

Query: 232 CPLPAPDPVSSQAQWPGSAHGVVLRPPENHNAGERELLECELKPKPR 278
           CP  +    SSQ       H   L P  N         +    PK R
Sbjct: 263 CPRKSASD-SSQRGSHADTHVQRLSPTMNPALNPTRAPKASRPPKMR 308



 Score = 83.2 bits (204), Expect = 3e-16
 Identities = 87/325 (26%), Positives = 134/325 (41%), Gaps = 52/325 (16%)

Query: 17  VVCSCPDKCYC--QSSTNF--VDCSQQGLAEIPSHLPPQTRT------------------ 54
           V  +CP  C C  QSS N   V+C ++    I    P  T                    
Sbjct: 336 VPLTCPSSCVCTSQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDL 395

Query: 55  --------LHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLT 106
                   LHL +N+I  +   AF ++  L  L L+ N L  L P  F GLQ LQ L L 
Sbjct: 396 LEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLE 455

Query: 107 QNSLLSLESRLFHSLPQLRELDLSSNNISHLPTSL-GETWENLTILAVQQNQLQQLD-RA 164
            N +  ++   F +L  L+ L L++N +  LP ++ G T   LT L ++ N    L  + 
Sbjct: 456 YNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNIFGGT--ALTRLNLRNNHFSHLPVKG 513

Query: 165 LLESMPSVRLLLLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRI 224
           +L+ +P+   + L++N W C C ++GLK W E       + + + CESP    G+ L  +
Sbjct: 514 VLDQLPAFIQIDLQENPWDCTCDIMGLKDWTE-HANSPVIINEVTCESPAKHAGEILKFL 572

Query: 225 PHELYQPCPLPAPDPVSSQAQWPGSAHGVVLRPPENHNAGERELLECELKPKPRPANLRH 284
             E    CP             P  + G VL    NHN      L   + P   P     
Sbjct: 573 GREAI--CP-----------DSPNLSDGTVL--SMNHNTDTPRSL--SVSPSSYPELHTE 615

Query: 285 AIATVIITGVVCGIVCLMMLAAAIY 309
              +V+I G++   +  +   A ++
Sbjct: 616 VPLSVLILGLLVVFILSVCFGAGLF 640


>gi|221136973 SLIT and NTRK-like family, member 2 [Homo sapiens]
          Length = 845

 Score = 93.2 bits (230), Expect = 3e-19
 Identities = 78/287 (27%), Positives = 124/287 (43%), Gaps = 36/287 (12%)

Query: 21  CPDKCYCQSSTNF--VDCSQQGLAEIPSHLPPQTR------------------------- 53
           C  +C C+   N   ++C  +G   +    PPQ R                         
Sbjct: 29  CKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRIYQLFLNGNLLTRLYPNEFVNYSNA 88

Query: 54  -TLHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLS 112
            TLHL +N +  +   AF  +  L  L+L+NN L  L    F GL+ L+ L    N + +
Sbjct: 89  VTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILREDTFLGLESLEYLQADYNYISA 148

Query: 113 LESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRA-LLESMPS 171
           +E+  F  L +L+ L L+ N +  LP+++   +  LT L ++ N+L+ +  A +LE +  
Sbjct: 149 IEAGAFSKLNKLKVLILNDNLLLSLPSNVFR-FVLLTHLDLRGNRLKVMPFAGVLEHIGG 207

Query: 172 VRLLLLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELYQP 231
           +  + L++N W C C LL LK WL+      G    I+CE+P    GKD+ ++  +    
Sbjct: 208 IMEIQLEENPWNCTCDLLPLKAWLDTITVFVG---EIVCETPFRLHGKDVTQLTRQ--DL 262

Query: 232 CPLPAPDPVSSQAQWPGSAHGVVLRPPENHNAGERELLECELKPKPR 278
           CP  +    SSQ       H   L P  N         +    PK R
Sbjct: 263 CPRKSASD-SSQRGSHADTHVQRLSPTMNPALNPTRAPKASRPPKMR 308



 Score = 83.2 bits (204), Expect = 3e-16
 Identities = 87/325 (26%), Positives = 134/325 (41%), Gaps = 52/325 (16%)

Query: 17  VVCSCPDKCYC--QSSTNF--VDCSQQGLAEIPSHLPPQTRT------------------ 54
           V  +CP  C C  QSS N   V+C ++    I    P  T                    
Sbjct: 336 VPLTCPSSCVCTSQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDL 395

Query: 55  --------LHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLT 106
                   LHL +N+I  +   AF ++  L  L L+ N L  L P  F GLQ LQ L L 
Sbjct: 396 LEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLE 455

Query: 107 QNSLLSLESRLFHSLPQLRELDLSSNNISHLPTSL-GETWENLTILAVQQNQLQQLD-RA 164
            N +  ++   F +L  L+ L L++N +  LP ++ G T   LT L ++ N    L  + 
Sbjct: 456 YNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNIFGGT--ALTRLNLRNNHFSHLPVKG 513

Query: 165 LLESMPSVRLLLLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRI 224
           +L+ +P+   + L++N W C C ++GLK W E       + + + CESP    G+ L  +
Sbjct: 514 VLDQLPAFIQIDLQENPWDCTCDIMGLKDWTE-HANSPVIINEVTCESPAKHAGEILKFL 572

Query: 225 PHELYQPCPLPAPDPVSSQAQWPGSAHGVVLRPPENHNAGERELLECELKPKPRPANLRH 284
             E    CP             P  + G VL    NHN      L   + P   P     
Sbjct: 573 GREAI--CP-----------DSPNLSDGTVL--SMNHNTDTPRSL--SVSPSSYPELHTE 615

Query: 285 AIATVIITGVVCGIVCLMMLAAAIY 309
              +V+I G++   +  +   A ++
Sbjct: 616 VPLSVLILGLLVVFILSVCFGAGLF 640


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.136    0.425 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,425,970
Number of Sequences: 37866
Number of extensions: 768514
Number of successful extensions: 4253
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 221
Number of HSP's successfully gapped in prelim test: 83
Number of HSP's that attempted gapping in prelim test: 2475
Number of HSP's gapped (non-prelim): 942
length of query: 345
length of database: 18,247,518
effective HSP length: 103
effective length of query: 242
effective length of database: 14,347,320
effective search space: 3472051440
effective search space used: 3472051440
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.