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Search of human proteins with 10092691
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|10092691 tight junction protein 3 [Homo sapiens]
(952 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|10092691 tight junction protein 3 [Homo sapiens] 1901 0.0
gi|116875765 tight junction protein 1 isoform b [Homo sapiens] 659 0.0
gi|116875767 tight junction protein 1 isoform a [Homo sapiens] 659 0.0
gi|42518070 tight junction protein 2 (zona occludens 2) isoform ... 565 e-161
gi|42518065 tight junction protein 2 (zona occludens 2) isoform ... 562 e-160
gi|169160873 PREDICTED: similar to hCG2040319 [Homo sapiens] 293 5e-79
gi|239747400 PREDICTED: similar to hCG2040319 [Homo sapiens] 293 5e-79
gi|239741226 PREDICTED: similar to hCG2040319 [Homo sapiens] 293 5e-79
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 156 1e-37
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 156 1e-37
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 149 9e-36
gi|95089461 discs large homolog 5 [Homo sapiens] 149 2e-35
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 137 4e-32
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 133 9e-31
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 130 8e-30
gi|119943108 synapse-associated protein 102 isoform b [Homo sapi... 129 1e-29
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 127 4e-29
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 127 4e-29
gi|218156270 chapsyn-110 isoform 4 [Homo sapiens] 100 5e-21
gi|38570142 membrane protein, palmitoylated 5 [Homo sapiens] 82 3e-15
gi|112382257 InaD-like [Homo sapiens] 79 3e-14
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom... 79 3e-14
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom... 77 8e-14
gi|74272282 membrane associated guanylate kinase, WW and PDZ dom... 77 8e-14
gi|27436957 membrane associated guanylate kinase, WW and PDZ dom... 75 2e-13
gi|111154074 palmitoylated membrane protein 7 [Homo sapiens] 70 7e-12
gi|218505835 membrane-associated guanylate kinase-related 3 iso... 65 3e-10
gi|13129124 caspase recruitment domain protein 14 isoform 1 [Hom... 65 4e-10
gi|148746189 multiple PDZ domain protein [Homo sapiens] 64 7e-10
gi|155969695 membrane-associated guanylate kinase-related 3 iso... 62 3e-09
>gi|10092691 tight junction protein 3 [Homo sapiens]
Length = 952
Score = 1901 bits (4925), Expect = 0.0
Identities = 952/952 (100%), Positives = 952/952 (100%)
Query: 1 MNLCGLMPIFPAPLDQVADMEELTIWEQHTATLSKDPRRGFGIAISGGRDRPGGSMVVSD 60
MNLCGLMPIFPAPLDQVADMEELTIWEQHTATLSKDPRRGFGIAISGGRDRPGGSMVVSD
Sbjct: 1 MNLCGLMPIFPAPLDQVADMEELTIWEQHTATLSKDPRRGFGIAISGGRDRPGGSMVVSD 60
Query: 61 VVPGGPAEGRLQTGDHIVMVNGVSMENATSAFAIQILKTCTKMANITVKRPRRIHLPATK 120
VVPGGPAEGRLQTGDHIVMVNGVSMENATSAFAIQILKTCTKMANITVKRPRRIHLPATK
Sbjct: 61 VVPGGPAEGRLQTGDHIVMVNGVSMENATSAFAIQILKTCTKMANITVKRPRRIHLPATK 120
Query: 121 ASPSSPGRQDSDEDDGPQRVEEVDQGRGYDGDSSSGSGRSWDERSRRPRPGRRGRAGSHG 180
ASPSSPGRQDSDEDDGPQRVEEVDQGRGYDGDSSSGSGRSWDERSRRPRPGRRGRAGSHG
Sbjct: 121 ASPSSPGRQDSDEDDGPQRVEEVDQGRGYDGDSSSGSGRSWDERSRRPRPGRRGRAGSHG 180
Query: 181 RRSPGGGSEANGLALVSGFKRLPRQDVQMKPVKSVLVKRRDSEEFGVKLGSQIFIKHITD 240
RRSPGGGSEANGLALVSGFKRLPRQDVQMKPVKSVLVKRRDSEEFGVKLGSQIFIKHITD
Sbjct: 181 RRSPGGGSEANGLALVSGFKRLPRQDVQMKPVKSVLVKRRDSEEFGVKLGSQIFIKHITD 240
Query: 241 SGLAARHRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRDRGQFLVNIPP 300
SGLAARHRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRDRGQFLVNIPP
Sbjct: 241 SGLAARHRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRDRGQFLVNIPP 300
Query: 301 AVSDSDSSPLEEGVTMADEMSSPPADISDLASELSQAPPSHIPPPPRHAQRSPEASQTDS 360
AVSDSDSSPLEEGVTMADEMSSPPADISDLASELSQAPPSHIPPPPRHAQRSPEASQTDS
Sbjct: 301 AVSDSDSSPLEEGVTMADEMSSPPADISDLASELSQAPPSHIPPPPRHAQRSPEASQTDS 360
Query: 361 PVESPRLRRESSVDSRTISEPDEQRSELPRESSYDIYRVPSSQSMEDRGYSPDTRVVRFL 420
PVESPRLRRESSVDSRTISEPDEQRSELPRESSYDIYRVPSSQSMEDRGYSPDTRVVRFL
Sbjct: 361 PVESPRLRRESSVDSRTISEPDEQRSELPRESSYDIYRVPSSQSMEDRGYSPDTRVVRFL 420
Query: 421 KGKSIGLRLAGGNDVGIFVSGVQAGSPADGQGIQEGDQILQVNDVPFQNLTREEAVQFLL 480
KGKSIGLRLAGGNDVGIFVSGVQAGSPADGQGIQEGDQILQVNDVPFQNLTREEAVQFLL
Sbjct: 421 KGKSIGLRLAGGNDVGIFVSGVQAGSPADGQGIQEGDQILQVNDVPFQNLTREEAVQFLL 480
Query: 481 GLPPGEEMELVTQRKQDIFWKMVQSRVGDSFYIRTHFELEPSPPSGLGFTRGDVFHVLDT 540
GLPPGEEMELVTQRKQDIFWKMVQSRVGDSFYIRTHFELEPSPPSGLGFTRGDVFHVLDT
Sbjct: 481 GLPPGEEMELVTQRKQDIFWKMVQSRVGDSFYIRTHFELEPSPPSGLGFTRGDVFHVLDT 540
Query: 541 LHPGPGQSHARGGHWLAVRMGRDLREQERGIIPNQSRAEQLASLEAAQRAVGVGPGSSAG 600
LHPGPGQSHARGGHWLAVRMGRDLREQERGIIPNQSRAEQLASLEAAQRAVGVGPGSSAG
Sbjct: 541 LHPGPGQSHARGGHWLAVRMGRDLREQERGIIPNQSRAEQLASLEAAQRAVGVGPGSSAG 600
Query: 601 SNARAEFWRLRGLRRGAKKTTQRSREDLSALTRQGRYPPYERVVLREASFKRPVVILGPV 660
SNARAEFWRLRGLRRGAKKTTQRSREDLSALTRQGRYPPYERVVLREASFKRPVVILGPV
Sbjct: 601 SNARAEFWRLRGLRRGAKKTTQRSREDLSALTRQGRYPPYERVVLREASFKRPVVILGPV 660
Query: 661 ADIAMQKLTAEMPDQFEIAETVSRTDSPSKIIKLDTVRVIAEKDKHALLDVTPSAIERLN 720
ADIAMQKLTAEMPDQFEIAETVSRTDSPSKIIKLDTVRVIAEKDKHALLDVTPSAIERLN
Sbjct: 661 ADIAMQKLTAEMPDQFEIAETVSRTDSPSKIIKLDTVRVIAEKDKHALLDVTPSAIERLN 720
Query: 721 YVQYYPIVVFFIPESRPALKALRQWLAPASRRSTRRLYAQAQKLRKHSSHLFTATIPLNG 780
YVQYYPIVVFFIPESRPALKALRQWLAPASRRSTRRLYAQAQKLRKHSSHLFTATIPLNG
Sbjct: 721 YVQYYPIVVFFIPESRPALKALRQWLAPASRRSTRRLYAQAQKLRKHSSHLFTATIPLNG 780
Query: 781 TSDTWYQELKAIIREQQTRPIWTAEDQLDGSLEDNLDLPHHGLADSSADLSCDSRVNSDY 840
TSDTWYQELKAIIREQQTRPIWTAEDQLDGSLEDNLDLPHHGLADSSADLSCDSRVNSDY
Sbjct: 781 TSDTWYQELKAIIREQQTRPIWTAEDQLDGSLEDNLDLPHHGLADSSADLSCDSRVNSDY 840
Query: 841 ETDGEGGAYTDGEGYTDGEGGPYTDVDDEPPAPALARSSEPVQADESQSPRDRGRISAHQ 900
ETDGEGGAYTDGEGYTDGEGGPYTDVDDEPPAPALARSSEPVQADESQSPRDRGRISAHQ
Sbjct: 841 ETDGEGGAYTDGEGYTDGEGGPYTDVDDEPPAPALARSSEPVQADESQSPRDRGRISAHQ 900
Query: 901 GAQVDSRHPQGQWRQDSMRTYEREALKKKFMRVHDAESSDEDGYDWGPATDL 952
GAQVDSRHPQGQWRQDSMRTYEREALKKKFMRVHDAESSDEDGYDWGPATDL
Sbjct: 901 GAQVDSRHPQGQWRQDSMRTYEREALKKKFMRVHDAESSDEDGYDWGPATDL 952
>gi|116875765 tight junction protein 1 isoform b [Homo sapiens]
Length = 1668
Score = 659 bits (1699), Expect = 0.0
Identities = 406/936 (43%), Positives = 550/936 (58%), Gaps = 130/936 (13%)
Query: 20 MEELTIWEQHTATLSKDPRRGFGIAISGGRDRPG-----GSMVVSDVVPGGPAEGRLQTG 74
MEE IWEQHT TL + P GFGIAISGGRD P S+V+SDV+ GGPAEG+LQ
Sbjct: 13 MEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAEGQLQEN 72
Query: 75 DHIVMVNGVSMENATSAFAIQILKTCTKMANITVKRPRRIHLPATKASPSSPGRQDSDED 134
D + MVNGVSM+N AFA+Q L+ K A IT++R +++ +P ++ P D++ED
Sbjct: 73 DRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVS--DNEED 130
Query: 135 DGPQRVEEVDQGRGYDGDSSSGSGRSWD-------ERSRRPRPGRRGRAGSHGRRSPGGG 187
+ + + GR G + S + W ERS PR RR A S
Sbjct: 131 SYDEEIHDPRSGRS--GVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQ-------- 180
Query: 188 SEANGLALVSGFKRLPRQDVQMKPVKSVLVKRRDSEEFGVKLGSQIFIKHITDSGLAARH 247
KP K LVK R +EE+G++L S IF+K I+ LAAR
Sbjct: 181 --------------------PAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARD 220
Query: 248 RGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRDRGQFLVNIPPAVSDSDS 307
+QEGD++L+ING ++N+SL D + LIE+S+GKL ++V RD L+N+P +SDS
Sbjct: 221 GNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPD-LSDSIH 279
Query: 308 SPLEEGVTMADEMSSPPADISDLASELSQAPPSHIPPPPRHAQRSPE--ASQTDSPVESP 365
S + D++S +I LAS+ S SH PP R RSP+ + +D SP
Sbjct: 280 SA---NASERDDIS----EIQSLASDHSGR--SHDRPPRRSRSRSPDQRSEPSDHSRHSP 330
Query: 366 RLRRESSVDSR-----------------------------TISEPDEQRSELPR------ 390
+ S+ SR T+ ++Q LP
Sbjct: 331 QQPSNGSLRSRDEERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYA 390
Query: 391 ---ESSYDIYRVPS-----SQSMEDRGYSPDTRVVRFLKGKSIGLRLAGGNDVGIFVSGV 442
+ D+ PS + + ED P ++V+F KG S+GLRLAGGNDVGIFV+GV
Sbjct: 391 QVGQPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGV 450
Query: 443 QAGSPADGQGIQEGDQILQVNDVPFQNLTREEAVQFLLGLPPGEEMELVTQRKQDIFWKM 502
SPA +G++EGDQIL+VN+V F N+ REEAV FLL LP GEE+ ++ Q+K+D++ ++
Sbjct: 451 LEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRI 510
Query: 503 VQSRVGDSFYIRTHFELEPSPPSGLGFTRGDVFHVLDTLHPGPGQSHARGGHWLAVRMGR 562
V+S VGDSFYIRTHFE E P GL F +G+VF V+DTL+ G + G WLA+R+G+
Sbjct: 511 VESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLYNG------KLGSWLAIRIGK 564
Query: 563 DLREQERGIIPNQSRAEQLASLEAAQRAVGVGPGSSAGSNARAEFWRLRGLRRGAKKTTQ 622
+ +E ERGIIPN++RAEQLAS++ P ++ G RA+FWR RGL R +K+ +
Sbjct: 565 NHKEVERGIIPNKNRAEQLASVQYTL------PKTAGGD--RADFWRFRGL-RSSKRNLR 615
Query: 623 RSREDLSALTRQGRYPPYERVVLREASFKRPVVILGPVADIAMQKLTAEMPDQFEIAETV 682
+SREDLSA Q ++P YERVVLREA F RPV I GP+AD+A +KL E PD ++IA++
Sbjct: 616 KSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIAKSE 675
Query: 683 SR---TDSPSK-IIKLDTVRVIAEKDKHALLDVTPSAIERLNYVQYYPIVVFFIPESRPA 738
R TD S II+L T++ I ++DKHALLDVTP+A++RLNY Q+YPIVVF P+S+
Sbjct: 676 PRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQG 735
Query: 739 LKALRQWLAPASRRSTRRLYAQAQKLRKHSSHLFTATIPLNGTSDTWYQELKAIIREQQT 798
+K +R L P SR+S R+LY ++ KLRK++ HLFT TI LN +D WY LK I++QQ
Sbjct: 736 VKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQN 795
Query: 799 RPIWTAEDQLDGSLEDNLDLPHHGLADSSAD------LSCDSRVNSDYE-TDGEGGAYTD 851
+ +W +E + DG+ D+LDL L+ SA S DSR SDYE TD EGGAYTD
Sbjct: 796 QLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTD 855
Query: 852 GEGYTDGEGGPYTDVDDEPPAPALARSSEPVQADES 887
E D PP A+ RSSEPV+ D S
Sbjct: 856 QE-----LDETLNDEVGTPPESAITRSSEPVREDSS 886
>gi|116875767 tight junction protein 1 isoform a [Homo sapiens]
Length = 1748
Score = 659 bits (1699), Expect = 0.0
Identities = 406/936 (43%), Positives = 550/936 (58%), Gaps = 130/936 (13%)
Query: 20 MEELTIWEQHTATLSKDPRRGFGIAISGGRDRPG-----GSMVVSDVVPGGPAEGRLQTG 74
MEE IWEQHT TL + P GFGIAISGGRD P S+V+SDV+ GGPAEG+LQ
Sbjct: 13 MEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAEGQLQEN 72
Query: 75 DHIVMVNGVSMENATSAFAIQILKTCTKMANITVKRPRRIHLPATKASPSSPGRQDSDED 134
D + MVNGVSM+N AFA+Q L+ K A IT++R +++ +P ++ P D++ED
Sbjct: 73 DRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVS--DNEED 130
Query: 135 DGPQRVEEVDQGRGYDGDSSSGSGRSWD-------ERSRRPRPGRRGRAGSHGRRSPGGG 187
+ + + GR G + S + W ERS PR RR A S
Sbjct: 131 SYDEEIHDPRSGRS--GVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQ-------- 180
Query: 188 SEANGLALVSGFKRLPRQDVQMKPVKSVLVKRRDSEEFGVKLGSQIFIKHITDSGLAARH 247
KP K LVK R +EE+G++L S IF+K I+ LAAR
Sbjct: 181 --------------------PAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARD 220
Query: 248 RGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRDRGQFLVNIPPAVSDSDS 307
+QEGD++L+ING ++N+SL D + LIE+S+GKL ++V RD L+N+P +SDS
Sbjct: 221 GNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPD-LSDSIH 279
Query: 308 SPLEEGVTMADEMSSPPADISDLASELSQAPPSHIPPPPRHAQRSPE--ASQTDSPVESP 365
S + D++S +I LAS+ S SH PP R RSP+ + +D SP
Sbjct: 280 SA---NASERDDIS----EIQSLASDHSGR--SHDRPPRRSRSRSPDQRSEPSDHSRHSP 330
Query: 366 RLRRESSVDSR-----------------------------TISEPDEQRSELPR------ 390
+ S+ SR T+ ++Q LP
Sbjct: 331 QQPSNGSLRSRDEERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYA 390
Query: 391 ---ESSYDIYRVPS-----SQSMEDRGYSPDTRVVRFLKGKSIGLRLAGGNDVGIFVSGV 442
+ D+ PS + + ED P ++V+F KG S+GLRLAGGNDVGIFV+GV
Sbjct: 391 QVGQPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGV 450
Query: 443 QAGSPADGQGIQEGDQILQVNDVPFQNLTREEAVQFLLGLPPGEEMELVTQRKQDIFWKM 502
SPA +G++EGDQIL+VN+V F N+ REEAV FLL LP GEE+ ++ Q+K+D++ ++
Sbjct: 451 LEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRI 510
Query: 503 VQSRVGDSFYIRTHFELEPSPPSGLGFTRGDVFHVLDTLHPGPGQSHARGGHWLAVRMGR 562
V+S VGDSFYIRTHFE E P GL F +G+VF V+DTL+ G + G WLA+R+G+
Sbjct: 511 VESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLYNG------KLGSWLAIRIGK 564
Query: 563 DLREQERGIIPNQSRAEQLASLEAAQRAVGVGPGSSAGSNARAEFWRLRGLRRGAKKTTQ 622
+ +E ERGIIPN++RAEQLAS++ P ++ G RA+FWR RGL R +K+ +
Sbjct: 565 NHKEVERGIIPNKNRAEQLASVQYTL------PKTAGGD--RADFWRFRGL-RSSKRNLR 615
Query: 623 RSREDLSALTRQGRYPPYERVVLREASFKRPVVILGPVADIAMQKLTAEMPDQFEIAETV 682
+SREDLSA Q ++P YERVVLREA F RPV I GP+AD+A +KL E PD ++IA++
Sbjct: 616 KSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIAKSE 675
Query: 683 SR---TDSPSK-IIKLDTVRVIAEKDKHALLDVTPSAIERLNYVQYYPIVVFFIPESRPA 738
R TD S II+L T++ I ++DKHALLDVTP+A++RLNY Q+YPIVVF P+S+
Sbjct: 676 PRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQG 735
Query: 739 LKALRQWLAPASRRSTRRLYAQAQKLRKHSSHLFTATIPLNGTSDTWYQELKAIIREQQT 798
+K +R L P SR+S R+LY ++ KLRK++ HLFT TI LN +D WY LK I++QQ
Sbjct: 736 VKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQN 795
Query: 799 RPIWTAEDQLDGSLEDNLDLPHHGLADSSAD------LSCDSRVNSDYE-TDGEGGAYTD 851
+ +W +E + DG+ D+LDL L+ SA S DSR SDYE TD EGGAYTD
Sbjct: 796 QLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTD 855
Query: 852 GEGYTDGEGGPYTDVDDEPPAPALARSSEPVQADES 887
E D PP A+ RSSEPV+ D S
Sbjct: 856 QE-----LDETLNDEVGTPPESAITRSSEPVREDSS 886
>gi|42518070 tight junction protein 2 (zona occludens 2) isoform 1
[Homo sapiens]
Length = 1190
Score = 565 bits (1456), Expect = e-161
Identities = 341/793 (43%), Positives = 480/793 (60%), Gaps = 57/793 (7%)
Query: 132 DEDDGPQRVEEVDQGRG--YDGDSSSGSGRSWDERSRRPRPGRRGRAGSHGRRSPGGGSE 189
D D GP R + D+ RG D D R++D R R H RS G S
Sbjct: 226 DHDFGPSRDRDRDRSRGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSR 285
Query: 190 ANGLALVSGFKRLPRQDVQMKP--VKSVLVKRRDSEEFGVKLGSQIFIKHITDSGLAARH 247
+ R P + + +P + +L+K R +EE+G++LGSQIF+K +T +GLA +
Sbjct: 286 SRE----HPHSRSPSPEPRGRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKD 341
Query: 248 RGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRDRGQFLVNIPPAVSDSDS 307
L EGD+IL+ING ++N+SL D R+LIEKS GKL L+VLRD Q L+NIP +++DSDS
Sbjct: 342 GNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRDSQQTLINIP-SLNDSDS 400
Query: 308 SPLEEGVTMADEMSSPPA--------DISDLASELSQAPPSHIPPPPRHAQRSPEASQTD 359
+ ++ SP D + +L + P S P R ++ T
Sbjct: 401 EIEDISEIESNRSFSPEERRHQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGA----TP 456
Query: 360 SPVESPRLRRESSVDSRTISEPDEQRSELPRESSYDIYRVPSSQSMEDRG-YSPDTRVVR 418
+P +S +V T EP Q P R S ED Y P+T++VR
Sbjct: 457 TPFKSTG-DIAGTVVPETNKEPRYQEDP-PAPQPKAAPRTFLRPSPEDEAIYGPNTKMVR 514
Query: 419 FLKGKSIGLRLAGGNDVGIFVSGVQAGSPADGQGIQEGDQILQVNDVPFQNLTREEAVQF 478
F KG S+GLRLAGGNDVGIFV+G+Q G+ A+ +G+QEGDQIL+VN F+ L RE+AV +
Sbjct: 515 FKKGDSVGLRLAGGNDVGIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLY 574
Query: 479 LLGLPPGEEMELVTQRKQDIFWKMVQSRVGDSFYIRTHFELEPSPPSGLGFTRGDVFHVL 538
LL +P GE + ++ Q + D++ ++ GDSF+IR+HFE E P L FTRG+VF V+
Sbjct: 575 LLEIPKGEMVTILAQSRADVYRDILACGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVV 634
Query: 539 DTLHPGPGQSHARGGHWLAVRMGRDLREQERGIIPNQSRAEQLASLEAAQRAVGVGPGSS 598
DTL+ G + G+WLAVR+G +L E+G+IPN+SRAEQ+AS++ AQR +
Sbjct: 635 DTLYDG------KLGNWLAVRIGNEL---EKGLIPNKSRAEQMASVQNAQR-------DN 678
Query: 599 AGSNARAEFWRLRGLRRGAKKTTQRSREDLSALTR-QGRYPPYERVVLREASFKRPVVIL 657
AG RA+FWR+RG R G KK ++SREDL+A+ ++P YERV+LREA FKRPVV+
Sbjct: 679 AGD--RADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYERVLLREAGFKRPVVLF 736
Query: 658 GPVADIAMQKLTAEMPDQFEIAETVSR---TDSPSKIIKLDTVRVIAEKDKHALLDVTPS 714
GP+ADIAM+KL E+PD F+ A+T + ++ + +++L+TVR I E+DKHALLDVTP
Sbjct: 737 GPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVRQIIEQDKHALLDVTPK 796
Query: 715 AIERLNYVQYYPIVVFFIPESRPALKALRQWLAPASRRSTRRLYAQAQKLRKHSSHLFTA 774
A++ LNY Q++PIV+FF P+SR +K +RQ L P S +S+R+L+ QA KL+K +HLFTA
Sbjct: 797 AVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTA 856
Query: 775 TIPLNGTSDTWYQELKAIIREQQTRPIWTAEDQLDGSLEDNLDLPHHGLADSSADLSCDS 834
TI LN +D+W+ LK I+ QQ +W +E +++G +D D + A + LSCDS
Sbjct: 857 TINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDDPEDRMSYLTAMGADYLSCDS 916
Query: 835 RVNSDYE-TDGEGGAYTDGEGYTDGEGGPYTDVDDEPPAPALARSSEPVQADES-QSPRD 892
R+ SD+E TDGEGGAYTD E + +EP ++ RSSEPVQ +ES + P
Sbjct: 917 RLISDFEDTDGEGGAYTDNE---------LDEPAEEPLVSSITRSSEPVQHEESIRKPSP 967
Query: 893 RGRISAHQGAQVD 905
R + A D
Sbjct: 968 EPRAQMRRAASSD 980
Score = 136 bits (342), Expect = 1e-31
Identities = 78/170 (45%), Positives = 102/170 (60%), Gaps = 20/170 (11%)
Query: 20 MEELTIWEQHTATLSKDPRRGFGIAISGGRDRPG-----GSMVVSDVVPGGPAEGRLQTG 74
MEEL IWEQ+T TL KD +RGFGIA+SGGRD P S+V+SDV+PGGPA+G LQ
Sbjct: 24 MEEL-IWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPADGLLQEN 82
Query: 75 DHIVMVNGVSMENATSAFAIQILKTCTKMANITVKRPRRIHLPATKASPSSPGRQDSDED 134
D +VMVNG ME+ +FA+Q L+ K+A I VKRPR++ + A +ASP D+D
Sbjct: 83 DRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPRKVQVAALQASP------PLDQD 136
Query: 135 DGPQRVEEVDQGRGYDG--------DSSSGSGRSWDERSRRPRPGRRGRA 176
D V + GR + +S G RSW++ R RP R R+
Sbjct: 137 DRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRPHERARS 186
Score = 45.8 bits (107), Expect = 2e-04
Identities = 62/273 (22%), Positives = 107/273 (39%), Gaps = 35/273 (12%)
Query: 51 RPGGSMVVSDVVPGGPA--EGRLQTGDHIVMVNGVSMENATSAFAIQILKTCTKMANITV 108
R G + V ++ G A +G L GD I+ +NG EN + A ++++ + V
Sbjct: 322 RLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVV 381
Query: 109 KRPRR---IHLPATKASPSSPGRQDSDEDDGPQRVEEVDQGRGYDGDSSSGSGRSWDER- 164
R + I++P+ S S +D E + + ++ Y S ER
Sbjct: 382 LRDSQQTLINIPSLNDSDSE--IEDISEIESNRSFSPEERRHQYSDYDYHSSSEKLKERP 439
Query: 165 -SRRPRPGRRGRAGSHGRRSPGGGSEANGL--------------------ALVSGFKRLP 203
SR P R R G+ G A + A F R
Sbjct: 440 SSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQEDPPAPQPKAAPRTFLRPS 499
Query: 204 RQDVQMKPVKSVLVKRRDSEEFGVKLGS----QIFIKHITDSGLAARHRGLQEGDLILQI 259
+D + + +V+ + + G++L IF+ I + G +A GLQEGD IL++
Sbjct: 500 PEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQE-GTSAEQEGLQEGDQILKV 558
Query: 260 NGVSSQNLSLND-TRRLIEKSEGKLSLLVLRDR 291
N + L D L+E +G++ ++ + R
Sbjct: 559 NTQDFRGLVREDAVLYLLEIPKGEMVTILAQSR 591
Score = 38.5 bits (88), Expect = 0.030
Identities = 22/65 (33%), Positives = 34/65 (52%), Gaps = 9/65 (13%)
Query: 423 KSIGLRLAGGND--------VGIFVSGVQAGSPADGQGIQEGDQILQVNDVPFQNLTREE 474
+ G+ ++GG D I +S V G PADG +QE D+++ VN P +++
Sbjct: 42 RGFGIAVSGGRDNPHFENGETSIVISDVLPGGPADGL-LQENDRVVMVNGTPMEDVLHSF 100
Query: 475 AVQFL 479
AVQ L
Sbjct: 101 AVQQL 105
>gi|42518065 tight junction protein 2 (zona occludens 2) isoform 2
[Homo sapiens]
Length = 1043
Score = 562 bits (1448), Expect = e-160
Identities = 336/773 (43%), Positives = 473/773 (61%), Gaps = 56/773 (7%)
Query: 132 DEDDGPQRVEEVDQGRG--YDGDSSSGSGRSWDERSRRPRPGRRGRAGSHGRRSPGGGSE 189
D D GP R + D+ RG D D R++D R R H RS G S
Sbjct: 226 DHDFGPSRDRDRDRSRGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSR 285
Query: 190 ANGLALVSGFKRLPRQDVQMKP--VKSVLVKRRDSEEFGVKLGSQIFIKHITDSGLAARH 247
+ R P + + +P + +L+K R +EE+G++LGSQIF+K +T +GLA +
Sbjct: 286 SRE----HPHSRSPSPEPRGRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKD 341
Query: 248 RGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRDRGQFLVNIPPAVSDSDS 307
L EGD+IL+ING ++N+SL D R+LIEKS GKL L+VLRD Q L+NIP +++DSDS
Sbjct: 342 GNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRDSQQTLINIP-SLNDSDS 400
Query: 308 SPLEEGVTMADEMSSPPA--------DISDLASELSQAPPSHIPPPPRHAQRSPEASQTD 359
+ ++ SP D + +L + P S P R ++ T
Sbjct: 401 EIEDISEIESNRSFSPEERRHQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGA----TP 456
Query: 360 SPVESPRLRRESSVDSRTISEPDEQRSELPRESSYDIYRVPSSQSMEDRG-YSPDTRVVR 418
+P +S +V T EP Q P R S ED Y P+T++VR
Sbjct: 457 TPFKSTG-DIAGTVVPETNKEPRYQEDP-PAPQPKAAPRTFLRPSPEDEAIYGPNTKMVR 514
Query: 419 FLKGKSIGLRLAGGNDVGIFVSGVQAGSPADGQGIQEGDQILQVNDVPFQNLTREEAVQF 478
F KG S+GLRLAGGNDVGIFV+G+Q G+ A+ +G+QEGDQIL+VN F+ L RE+AV +
Sbjct: 515 FKKGDSVGLRLAGGNDVGIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLY 574
Query: 479 LLGLPPGEEMELVTQRKQDIFWKMVQSRVGDSFYIRTHFELEPSPPSGLGFTRGDVFHVL 538
LL +P GE + ++ Q + D++ ++ GDSF+IR+HFE E P L FTRG+VF V+
Sbjct: 575 LLEIPKGEMVTILAQSRADVYRDILACGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVV 634
Query: 539 DTLHPGPGQSHARGGHWLAVRMGRDLREQERGIIPNQSRAEQLASLEAAQRAVGVGPGSS 598
DTL+ G + G+WLAVR+G +L E+G+IPN+SRAEQ+AS++ AQR +
Sbjct: 635 DTLYDG------KLGNWLAVRIGNEL---EKGLIPNKSRAEQMASVQNAQR-------DN 678
Query: 599 AGSNARAEFWRLRGLRRGAKKTTQRSREDLSALTR-QGRYPPYERVVLREASFKRPVVIL 657
AG RA+FWR+RG R G KK ++SREDL+A+ ++P YERV+LREA FKRPVV+
Sbjct: 679 AGD--RADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYERVLLREAGFKRPVVLF 736
Query: 658 GPVADIAMQKLTAEMPDQFEIAETVSR---TDSPSKIIKLDTVRVIAEKDKHALLDVTPS 714
GP+ADIAM+KL E+PD F+ A+T + ++ + +++L+TVR I E+DKHALLDVTP
Sbjct: 737 GPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVRQIIEQDKHALLDVTPK 796
Query: 715 AIERLNYVQYYPIVVFFIPESRPALKALRQWLAPASRRSTRRLYAQAQKLRKHSSHLFTA 774
A++ LNY Q++PIV+FF P+SR +K +RQ L P S +S+R+L+ QA KL+K +HLFTA
Sbjct: 797 AVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTA 856
Query: 775 TIPLNGTSDTWYQELKAIIREQQTRPIWTAEDQLDGSLEDNLDLPHHGLADSSADLSCDS 834
TI LN +D+W+ LK I+ QQ +W +E +++G +D D + A + LSCDS
Sbjct: 857 TINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDDPEDRMSYLTAMGADYLSCDS 916
Query: 835 RVNSDYE-TDGEGGAYTDGEGYTDGEGGPYTDVDDEPPAPALARSSEPVQADE 886
R+ SD+E TDGEGGAYTD E + +EP ++ RSSEPVQ +E
Sbjct: 917 RLISDFEDTDGEGGAYTDNE---------LDEPAEEPLVSSITRSSEPVQHEE 960
Score = 136 bits (342), Expect = 1e-31
Identities = 78/170 (45%), Positives = 102/170 (60%), Gaps = 20/170 (11%)
Query: 20 MEELTIWEQHTATLSKDPRRGFGIAISGGRDRPG-----GSMVVSDVVPGGPAEGRLQTG 74
MEEL IWEQ+T TL KD +RGFGIA+SGGRD P S+V+SDV+PGGPA+G LQ
Sbjct: 24 MEEL-IWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPADGLLQEN 82
Query: 75 DHIVMVNGVSMENATSAFAIQILKTCTKMANITVKRPRRIHLPATKASPSSPGRQDSDED 134
D +VMVNG ME+ +FA+Q L+ K+A I VKRPR++ + A +ASP D+D
Sbjct: 83 DRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPRKVQVAALQASP------PLDQD 136
Query: 135 DGPQRVEEVDQGRGYDG--------DSSSGSGRSWDERSRRPRPGRRGRA 176
D V + GR + +S G RSW++ R RP R R+
Sbjct: 137 DRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRPHERARS 186
Score = 45.8 bits (107), Expect = 2e-04
Identities = 62/273 (22%), Positives = 107/273 (39%), Gaps = 35/273 (12%)
Query: 51 RPGGSMVVSDVVPGGPA--EGRLQTGDHIVMVNGVSMENATSAFAIQILKTCTKMANITV 108
R G + V ++ G A +G L GD I+ +NG EN + A ++++ + V
Sbjct: 322 RLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVV 381
Query: 109 KRPRR---IHLPATKASPSSPGRQDSDEDDGPQRVEEVDQGRGYDGDSSSGSGRSWDER- 164
R + I++P+ S S +D E + + ++ Y S ER
Sbjct: 382 LRDSQQTLINIPSLNDSDSE--IEDISEIESNRSFSPEERRHQYSDYDYHSSSEKLKERP 439
Query: 165 -SRRPRPGRRGRAGSHGRRSPGGGSEANGL--------------------ALVSGFKRLP 203
SR P R R G+ G A + A F R
Sbjct: 440 SSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQEDPPAPQPKAAPRTFLRPS 499
Query: 204 RQDVQMKPVKSVLVKRRDSEEFGVKLGS----QIFIKHITDSGLAARHRGLQEGDLILQI 259
+D + + +V+ + + G++L IF+ I + G +A GLQEGD IL++
Sbjct: 500 PEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQE-GTSAEQEGLQEGDQILKV 558
Query: 260 NGVSSQNLSLND-TRRLIEKSEGKLSLLVLRDR 291
N + L D L+E +G++ ++ + R
Sbjct: 559 NTQDFRGLVREDAVLYLLEIPKGEMVTILAQSR 591
Score = 38.5 bits (88), Expect = 0.030
Identities = 22/65 (33%), Positives = 34/65 (52%), Gaps = 9/65 (13%)
Query: 423 KSIGLRLAGGND--------VGIFVSGVQAGSPADGQGIQEGDQILQVNDVPFQNLTREE 474
+ G+ ++GG D I +S V G PADG +QE D+++ VN P +++
Sbjct: 42 RGFGIAVSGGRDNPHFENGETSIVISDVLPGGPADGL-LQENDRVVMVNGTPMEDVLHSF 100
Query: 475 AVQFL 479
AVQ L
Sbjct: 101 AVQQL 105
>gi|169160873 PREDICTED: similar to hCG2040319 [Homo sapiens]
Length = 274
Score = 293 bits (750), Expect = 5e-79
Identities = 155/196 (79%), Positives = 156/196 (79%), Gaps = 5/196 (2%)
Query: 745 WLAPASRRSTRRLYAQAQKLRKHSSHLFTATIPLNGTSDTWYQELKAIIREQQTRPIWTA 804
WLAPAS RSTRRLYAQAQKLRK SSHLFTATIPLNGTSDTWYQE KAIIREQQTRPIWTA
Sbjct: 20 WLAPASCRSTRRLYAQAQKLRKQSSHLFTATIPLNGTSDTWYQEFKAIIREQQTRPIWTA 79
Query: 805 EDQLDGSLEDNLDLPHHGLADSSADLSCDSRVNSDY--ETDGEGGAYTDGEGYTDGEGGP 862
ED+LDGSLEDN PH GLADSSADLSCDSRVNSDY GGP
Sbjct: 80 EDKLDGSLEDN---PHRGLADSSADLSCDSRVNSDYWRRRKARAARTLMASATQTASGGP 136
Query: 863 YTDVDDEPPAPALARSSEPVQADESQSPRDRGRISAHQGAQVDSRHPQGQWRQDSMRTYE 922
YTD DDE PAPAL RSSEPVQADE QSPR RGRISAHQG QVDS HPQGQ RQDSMRT E
Sbjct: 137 YTDADDELPAPALDRSSEPVQADEPQSPRVRGRISAHQGPQVDSPHPQGQRRQDSMRTCE 196
Query: 923 REALKKKFMRVHDAES 938
EALKKKF RV DAES
Sbjct: 197 PEALKKKFTRVRDAES 212
>gi|239747400 PREDICTED: similar to hCG2040319 [Homo sapiens]
Length = 274
Score = 293 bits (750), Expect = 5e-79
Identities = 155/196 (79%), Positives = 156/196 (79%), Gaps = 5/196 (2%)
Query: 745 WLAPASRRSTRRLYAQAQKLRKHSSHLFTATIPLNGTSDTWYQELKAIIREQQTRPIWTA 804
WLAPAS RSTRRLYAQAQKLRK SSHLFTATIPLNGTSDTWYQE KAIIREQQTRPIWTA
Sbjct: 20 WLAPASCRSTRRLYAQAQKLRKQSSHLFTATIPLNGTSDTWYQEFKAIIREQQTRPIWTA 79
Query: 805 EDQLDGSLEDNLDLPHHGLADSSADLSCDSRVNSDY--ETDGEGGAYTDGEGYTDGEGGP 862
ED+LDGSLEDN PH GLADSSADLSCDSRVNSDY GGP
Sbjct: 80 EDKLDGSLEDN---PHRGLADSSADLSCDSRVNSDYWRRRKARAARTLMASATQTASGGP 136
Query: 863 YTDVDDEPPAPALARSSEPVQADESQSPRDRGRISAHQGAQVDSRHPQGQWRQDSMRTYE 922
YTD DDE PAPAL RSSEPVQADE QSPR RGRISAHQG QVDS HPQGQ RQDSMRT E
Sbjct: 137 YTDADDELPAPALDRSSEPVQADEPQSPRVRGRISAHQGPQVDSPHPQGQRRQDSMRTCE 196
Query: 923 REALKKKFMRVHDAES 938
EALKKKF RV DAES
Sbjct: 197 PEALKKKFTRVRDAES 212
>gi|239741226 PREDICTED: similar to hCG2040319 [Homo sapiens]
Length = 274
Score = 293 bits (750), Expect = 5e-79
Identities = 155/196 (79%), Positives = 156/196 (79%), Gaps = 5/196 (2%)
Query: 745 WLAPASRRSTRRLYAQAQKLRKHSSHLFTATIPLNGTSDTWYQELKAIIREQQTRPIWTA 804
WLAPAS RSTRRLYAQAQKLRK SSHLFTATIPLNGTSDTWYQE KAIIREQQTRPIWTA
Sbjct: 20 WLAPASCRSTRRLYAQAQKLRKQSSHLFTATIPLNGTSDTWYQEFKAIIREQQTRPIWTA 79
Query: 805 EDQLDGSLEDNLDLPHHGLADSSADLSCDSRVNSDY--ETDGEGGAYTDGEGYTDGEGGP 862
ED+LDGSLEDN PH GLADSSADLSCDSRVNSDY GGP
Sbjct: 80 EDKLDGSLEDN---PHRGLADSSADLSCDSRVNSDYWRRRKARAARTLMASATQTASGGP 136
Query: 863 YTDVDDEPPAPALARSSEPVQADESQSPRDRGRISAHQGAQVDSRHPQGQWRQDSMRTYE 922
YTD DDE PAPAL RSSEPVQADE QSPR RGRISAHQG QVDS HPQGQ RQDSMRT E
Sbjct: 137 YTDADDELPAPALDRSSEPVQADEPQSPRVRGRISAHQGPQVDSPHPQGQRRQDSMRTCE 196
Query: 923 REALKKKFMRVHDAES 938
EALKKKF RV DAES
Sbjct: 197 PEALKKKFTRVRDAES 212
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 156 bits (394), Expect = 1e-37
Identities = 165/686 (24%), Positives = 275/686 (40%), Gaps = 156/686 (22%)
Query: 231 SQIFIKHITDSGLAARHRGLQEGDLILQINGVSSQNLS-------LNDTRRLIEKSEGKL 283
+ I++ I D G A + LQ GD +L +N S + ++ L +T ++ GK
Sbjct: 325 NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKP 384
Query: 284 SLLVLRDRG-------------------------QFLVNIPPAVSDSDSSPLEEGVTMAD 318
+ + + D ++ ++PP +S SP+ + + + D
Sbjct: 385 TTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPP-ISPGRYSPIPKHMLVDD 443
Query: 319 EMSSPPADISDLASELSQAPPSHIPPPPRHAQRSPEASQTDSPVESPRLRRESSVDSRTI 378
+ + PP + ++L P S PRH SP + +P + +
Sbjct: 444 DYTRPPEPVYSTVNKLCDKPAS-----PRHY--SPVECDKSFLLSAPYSHYHLGLLPDSE 496
Query: 379 SEPDEQRSELPRESSYDIYRVPSSQSMEDRGYSPDTRVVRFLKGKS-IGLRLAGGND-VG 436
Q S R+ S + R S + + R V KG + +G + GG D G
Sbjct: 497 MTSHSQHSTATRQPSMTLQRAVSLEG--------EPRKVVLHKGSTGLGFNIVGGEDGEG 548
Query: 437 IFVSGVQAGSPADGQG-IQEGDQILQVNDVPFQNLTREEAVQFLLGLPPGEEMELVTQRK 495
IFVS + AG PAD G +Q GDQIL VN + + + E+A L G G+ + ++ Q +
Sbjct: 549 IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA--GQTVTIIAQYQ 606
Query: 496 QDIFWKMVQSRVGD-----------------------SFYIRTHFELEPS-----PPSGL 527
+ + + ++++ D S Y+R F+ + S P GL
Sbjct: 607 PEDYARF-EAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGL 665
Query: 528 GFTRGDVFHVLDTLHPGPGQSHARGGHWLAVRMGRDLREQERGIIPNQSRAE--QLASLE 585
F GD+ HV++ + W A R+ + +E G+IP++ R E + A L+
Sbjct: 666 SFKYGDILHVINA---------SDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLK 716
Query: 586 AAQRAVGVGPGSSAGS-----------NARAEFWRLRGLRRGAKKTTQRSREDLSALTRQ 634
+ G S GS + + F++ + +R +EDL
Sbjct: 717 TVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLIL---- 772
Query: 635 GRYPPYERVVLREASFKRPVVILGPVADIAMQKLTAEMPDQFEIAETVSRTDSPSKIIKL 694
YE V +E ++ RPV+ILGP+ D L +E PD+F V T P + ++
Sbjct: 773 ----SYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKF--GSCVPHTTRPKRDYEV 826
Query: 695 D--------------------------------------TVRVIAEKDKHALLDVTPSAI 716
D +VR +AE+ KH +LDV+ +AI
Sbjct: 827 DGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAI 886
Query: 717 ERLNYVQYYPIVVFFIPESRPALKALRQWLAPASRRSTRRLYAQAQKLRKHSSHLFTATI 776
+RL Q YPI +F P S L + + L + ++ Y +A KL + FTA +
Sbjct: 887 KRLQVAQLYPIAIFIKPRSLEPLMEMNKRL---TEEQAKKTYDRAIKLEQEFGEYFTAIV 943
Query: 777 PLNGTSDTWYQELKAIIREQQTRPIW 802
T + Y + K +I EQ IW
Sbjct: 944 Q-GDTLEDIYNQCKLVIEEQSGPFIW 968
Score = 55.1 bits (131), Expect = 3e-07
Identities = 34/90 (37%), Positives = 54/90 (60%), Gaps = 7/90 (7%)
Query: 33 LSKDPRRGFGIAISGG---RDRPG-GSMVVSDVVPGGPAE--GRLQTGDHIVMVNGVSME 86
L K P+ G G +I+GG + PG S+ V+ ++ GG A+ GRLQ GD ++MVN S+E
Sbjct: 301 LFKGPK-GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLE 359
Query: 87 NATSAFAIQILKTCTKMANITVKRPRRIHL 116
T A+ ILK +++ + V +P I++
Sbjct: 360 EVTHEEAVAILKNTSEVVYLKVGKPTTIYM 389
Score = 45.8 bits (107), Expect = 2e-04
Identities = 30/81 (37%), Positives = 41/81 (50%), Gaps = 12/81 (14%)
Query: 28 QHTATLSKDPRR--------GFGIAISGGRDRPGGSMVVSDVVPGGPAE--GRLQTGDHI 77
Q +L +PR+ G G I GG D G + VS ++ GGPA+ G LQ GD I
Sbjct: 515 QRAVSLEGEPRKVVLHKGSTGLGFNIVGGED--GEGIFVSFILAGGPADLSGELQRGDQI 572
Query: 78 VMVNGVSMENATSAFAIQILK 98
+ VNG+ + A+ A LK
Sbjct: 573 LSVNGIDLRGASHEQAAAALK 593
Score = 39.3 bits (90), Expect = 0.018
Identities = 25/72 (34%), Positives = 38/72 (52%), Gaps = 9/72 (12%)
Query: 417 VRFLKG-KSIGLRLAGG-------NDVGIFVSGVQAGSPADGQG-IQEGDQILQVNDVPF 467
++ KG K +G +AGG D I+V+ + G A G +Q GD++L VN+
Sbjct: 299 IKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSL 358
Query: 468 QNLTREEAVQFL 479
+ +T EEAV L
Sbjct: 359 EEVTHEEAVAIL 370
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 156 bits (394), Expect = 1e-37
Identities = 165/686 (24%), Positives = 275/686 (40%), Gaps = 156/686 (22%)
Query: 231 SQIFIKHITDSGLAARHRGLQEGDLILQINGVSSQNLS-------LNDTRRLIEKSEGKL 283
+ I++ I D G A + LQ GD +L +N S + ++ L +T ++ GK
Sbjct: 220 NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKP 279
Query: 284 SLLVLRDRG-------------------------QFLVNIPPAVSDSDSSPLEEGVTMAD 318
+ + + D ++ ++PP +S SP+ + + + D
Sbjct: 280 TTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPP-ISPGRYSPIPKHMLVDD 338
Query: 319 EMSSPPADISDLASELSQAPPSHIPPPPRHAQRSPEASQTDSPVESPRLRRESSVDSRTI 378
+ + PP + ++L P S PRH SP + +P + +
Sbjct: 339 DYTRPPEPVYSTVNKLCDKPAS-----PRHY--SPVECDKSFLLSAPYSHYHLGLLPDSE 391
Query: 379 SEPDEQRSELPRESSYDIYRVPSSQSMEDRGYSPDTRVVRFLKGKS-IGLRLAGGND-VG 436
Q S R+ S + R S + + R V KG + +G + GG D G
Sbjct: 392 MTSHSQHSTATRQPSMTLQRAVSLEG--------EPRKVVLHKGSTGLGFNIVGGEDGEG 443
Query: 437 IFVSGVQAGSPADGQG-IQEGDQILQVNDVPFQNLTREEAVQFLLGLPPGEEMELVTQRK 495
IFVS + AG PAD G +Q GDQIL VN + + + E+A L G G+ + ++ Q +
Sbjct: 444 IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA--GQTVTIIAQYQ 501
Query: 496 QDIFWKMVQSRVGD-----------------------SFYIRTHFELEPS-----PPSGL 527
+ + + ++++ D S Y+R F+ + S P GL
Sbjct: 502 PEDYARF-EAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGL 560
Query: 528 GFTRGDVFHVLDTLHPGPGQSHARGGHWLAVRMGRDLREQERGIIPNQSRAE--QLASLE 585
F GD+ HV++ + W A R+ + +E G+IP++ R E + A L+
Sbjct: 561 SFKYGDILHVINA---------SDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLK 611
Query: 586 AAQRAVGVGPGSSAGS-----------NARAEFWRLRGLRRGAKKTTQRSREDLSALTRQ 634
+ G S GS + + F++ + +R +EDL
Sbjct: 612 TVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLIL---- 667
Query: 635 GRYPPYERVVLREASFKRPVVILGPVADIAMQKLTAEMPDQFEIAETVSRTDSPSKIIKL 694
YE V +E ++ RPV+ILGP+ D L +E PD+F V T P + ++
Sbjct: 668 ----SYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKF--GSCVPHTTRPKRDYEV 721
Query: 695 D--------------------------------------TVRVIAEKDKHALLDVTPSAI 716
D +VR +AE+ KH +LDV+ +AI
Sbjct: 722 DGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAI 781
Query: 717 ERLNYVQYYPIVVFFIPESRPALKALRQWLAPASRRSTRRLYAQAQKLRKHSSHLFTATI 776
+RL Q YPI +F P S L + + L + ++ Y +A KL + FTA +
Sbjct: 782 KRLQVAQLYPIAIFIKPRSLEPLMEMNKRL---TEEQAKKTYDRAIKLEQEFGEYFTAIV 838
Query: 777 PLNGTSDTWYQELKAIIREQQTRPIW 802
T + Y + K +I EQ IW
Sbjct: 839 Q-GDTLEDIYNQCKLVIEEQSGPFIW 863
Score = 55.1 bits (131), Expect = 3e-07
Identities = 34/90 (37%), Positives = 54/90 (60%), Gaps = 7/90 (7%)
Query: 33 LSKDPRRGFGIAISGG---RDRPG-GSMVVSDVVPGGPAE--GRLQTGDHIVMVNGVSME 86
L K P+ G G +I+GG + PG S+ V+ ++ GG A+ GRLQ GD ++MVN S+E
Sbjct: 196 LFKGPK-GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLE 254
Query: 87 NATSAFAIQILKTCTKMANITVKRPRRIHL 116
T A+ ILK +++ + V +P I++
Sbjct: 255 EVTHEEAVAILKNTSEVVYLKVGKPTTIYM 284
Score = 45.8 bits (107), Expect = 2e-04
Identities = 30/81 (37%), Positives = 41/81 (50%), Gaps = 12/81 (14%)
Query: 28 QHTATLSKDPRR--------GFGIAISGGRDRPGGSMVVSDVVPGGPAE--GRLQTGDHI 77
Q +L +PR+ G G I GG D G + VS ++ GGPA+ G LQ GD I
Sbjct: 410 QRAVSLEGEPRKVVLHKGSTGLGFNIVGGED--GEGIFVSFILAGGPADLSGELQRGDQI 467
Query: 78 VMVNGVSMENATSAFAIQILK 98
+ VNG+ + A+ A LK
Sbjct: 468 LSVNGIDLRGASHEQAAAALK 488
Score = 39.3 bits (90), Expect = 0.018
Identities = 25/72 (34%), Positives = 38/72 (52%), Gaps = 9/72 (12%)
Query: 417 VRFLKG-KSIGLRLAGG-------NDVGIFVSGVQAGSPADGQG-IQEGDQILQVNDVPF 467
++ KG K +G +AGG D I+V+ + G A G +Q GD++L VN+
Sbjct: 194 IKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSL 253
Query: 468 QNLTREEAVQFL 479
+ +T EEAV L
Sbjct: 254 EEVTHEEAVAIL 265
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 149 bits (377), Expect = 9e-36
Identities = 156/642 (24%), Positives = 255/642 (39%), Gaps = 138/642 (21%)
Query: 231 SQIFIKHITDSGLAARHRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRD 290
+ I++ I D G A + LQ GD +L +N S + ++ + +++ + + L V +
Sbjct: 169 NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKP 228
Query: 291 RGQFLVNI--PPAVSDSDSSPLEEGVTMADEMSSPPADISDLASELSQAPPSHIPPPPRH 348
++ + PP ++ S S P+E + + S + + L P P P+H
Sbjct: 229 TTIYMTDPYGPPDITHSYSPPME------NHLLSGNNGTLEYKTSLPPISPGRYSPIPKH 282
Query: 349 AQRSPEASQTDSPVESPRLRRESSVDSRTISEPDEQRSELPRESSYDIYRVPSSQSMEDR 408
+ T S R+ S R +S E R
Sbjct: 283 MLVDDD--YTSHSQHSTATRQPSMTLQRAVSLEGEPR----------------------- 317
Query: 409 GYSPDTRVVRFLKGKSIGLRLAGGND-VGIFVSGVQAGSPADGQG-IQEGDQILQVNDVP 466
+VV +G + GG D GIFVS + AG PAD G +Q GDQIL VN +
Sbjct: 318 ------KVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGID 371
Query: 467 FQNLTREEAVQFLLGLPPGEEMELVTQRKQDIFWKMVQSRVGD----------------- 509
+ + E+A L G G+ + ++ Q + + + + ++++ D
Sbjct: 372 LRGASHEQAAAALKGA--GQTVTIIAQYQPEDYARF-EAKIHDLREQMMNHSMSSGSGSL 428
Query: 510 ------SFYIRTHFELEPS-----PPSGLGFTRGDVFHVLDTLHPGPGQSHARGGHWLAV 558
S Y+R F+ + S P GL F GD+ HV++ + W A
Sbjct: 429 RTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINA---------SDDEWWQAR 479
Query: 559 RMGRDLREQERGIIPNQSRAEQLASLEAAQRAVGVGPGSSAGSNARAEFWRLRGLRRGAK 618
R+ + +E G+IP++ R E+ PG +++ + L G K
Sbjct: 480 RVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVI---DSKGDIPGLGDDGYGTK 536
Query: 619 KTTQRSREDLSALTRQGRYPPYERVVLREASFKRPVVILGPVADIAMQKLTAEMPDQFEI 678
T R +EDL YE V +E ++ RPV+ILGP+ D L +E PD+F
Sbjct: 537 --TLRGQEDLIL--------SYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKF-- 584
Query: 679 AETVSRTDSPSKIIKLD--------------------------------------TVRVI 700
V T P + ++D +VR +
Sbjct: 585 GSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFV 644
Query: 701 AEKDKHALLDVTPSAIERLNYVQYYPIVVFFIPESRPALKALRQWLAPASRRSTRRLYAQ 760
AE+ KH +LDV+ +AI+RL Q YPI +F P S L + + L + ++ Y +
Sbjct: 645 AERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRL---TEEQAKKTYDR 701
Query: 761 AQKLRKHSSHLFTATIPLNGTSDTWYQELKAIIREQQTRPIW 802
A KL + FTA + T + Y + K +I EQ IW
Sbjct: 702 AIKLEQEFGEYFTAIVQ-GDTLEDIYNQCKLVIEEQSGPFIW 742
Score = 60.8 bits (146), Expect = 6e-09
Identities = 72/253 (28%), Positives = 106/253 (41%), Gaps = 38/253 (15%)
Query: 33 LSKDPRRGFGIAISGG---RDRPG-GSMVVSDVVPGGPAE--GRLQTGDHIVMVNGVSME 86
L K P+ G G +I+GG + PG S+ V+ ++ GG A+ GRLQ GD ++MVN S+E
Sbjct: 145 LFKGPK-GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLE 203
Query: 87 NATSAFAIQILKTCTKMANITVKRPRRIHLPATKASPSSPGRQDSDEDDGPQRVEEVDQG 146
T A+ ILK +++ + V +P I++ P P D P
Sbjct: 204 EVTHEEAVAILKNTSEVVYLKVGKPTTIYM----TDPYGP--PDITHSYSPP-------- 249
Query: 147 RGYDGDSSSGSGRSWDERSRRP--RPGRRGRAGSHGRRSPGGGSEANGLALVSGFKRLPR 204
+ SG+ + + ++ P PGR H S + S R P
Sbjct: 250 --MENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQH----STATRQPS 303
Query: 205 QDVQM------KPVKSVLVKRRDSEEF---GVKLGSQIFIKHITDSGLAARHRGLQEGDL 255
+Q +P K VL K F G + G IF+ I G A LQ GD
Sbjct: 304 MTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQ 363
Query: 256 ILQINGVSSQNLS 268
IL +NG+ + S
Sbjct: 364 ILSVNGIDLRGAS 376
Score = 46.6 bits (109), Expect = 1e-04
Identities = 26/81 (32%), Positives = 44/81 (54%), Gaps = 6/81 (7%)
Query: 40 GFGIAISGGRDRP----GGSMVVSDVVPGGPA--EGRLQTGDHIVMVNGVSMENATSAFA 93
G G +I+GG D P + ++ ++PGG A +GRL+ D I+ VN V + + + A
Sbjct: 56 GLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKA 115
Query: 94 IQILKTCTKMANITVKRPRRI 114
++ LK + + V+R R I
Sbjct: 116 VEALKEAGSIVRLYVRRRRPI 136
Score = 45.8 bits (107), Expect = 2e-04
Identities = 30/81 (37%), Positives = 41/81 (50%), Gaps = 12/81 (14%)
Query: 28 QHTATLSKDPRR--------GFGIAISGGRDRPGGSMVVSDVVPGGPAE--GRLQTGDHI 77
Q +L +PR+ G G I GG D G + VS ++ GGPA+ G LQ GD I
Sbjct: 307 QRAVSLEGEPRKVVLHKGSTGLGFNIVGGED--GEGIFVSFILAGGPADLSGELQRGDQI 364
Query: 78 VMVNGVSMENATSAFAIQILK 98
+ VNG+ + A+ A LK
Sbjct: 365 LSVNGIDLRGASHEQAAAALK 385
Score = 39.3 bits (90), Expect = 0.018
Identities = 25/72 (34%), Positives = 38/72 (52%), Gaps = 9/72 (12%)
Query: 417 VRFLKG-KSIGLRLAGG-------NDVGIFVSGVQAGSPADGQG-IQEGDQILQVNDVPF 467
++ KG K +G +AGG D I+V+ + G A G +Q GD++L VN+
Sbjct: 143 IKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSL 202
Query: 468 QNLTREEAVQFL 479
+ +T EEAV L
Sbjct: 203 EEVTHEEAVAIL 214
>gi|95089461 discs large homolog 5 [Homo sapiens]
Length = 1919
Score = 149 bits (375), Expect = 2e-35
Identities = 161/628 (25%), Positives = 279/628 (44%), Gaps = 112/628 (17%)
Query: 219 RRDSEEFGVKLGSQ----IFIKHITDSGLAARHRGLQEGDLILQINGVSSQNLSLNDTRR 274
++ SE G+ + S I++ +T G A GL+ GD +L+ NG++ ++ + R
Sbjct: 1354 QKGSEPLGISIVSGEKGGIYVSKVT-VGSIAHQAGLEYGDQLLEFNGINLRSATEQQARL 1412
Query: 275 LIEKSEGKLSLLVLRDRGQFLVNIPPAVSDSDSSPLEEGVTMADEMSSPPADISDLASEL 334
+I + +++L Q+ ++ S S SS
Sbjct: 1413 IIGQQCDTITILA-----QYNPHVHQLSSHSRSS-------------------------- 1441
Query: 335 SQAPPSHIPPPPRHAQRSPEASQTDSPVESPRLRRESSVDSRTISEPDEQRSELP-RESS 393
SH+ P H+ + + S T +P E P S +D + E DE S P ++SS
Sbjct: 1442 -----SHLDPAGTHS--TLQGSGTTTP-EHP-----SVIDP--LMEQDEGPSTPPAKQSS 1486
Query: 394 YDIYRVPSSQSMEDRGYSPDTRVVRFLKGKSI--GLRLAGGNDVGIFVSGVQAGSPADG- 450
I + +++E R V F+K + G+ L GGN G+FV+ V+ SPA G
Sbjct: 1487 SRIAGDANKKTLEPR--------VVFIKKSQLELGVHLCGGNLHGVFVAEVEDDSPAKGP 1538
Query: 451 QGIQEGDQILQVNDVPFQNLTREEAVQFLLGLPPGEEMELVTQRKQDIFWKMVQSRVGDS 510
G+ GD IL+ + +N T EE ++ L P + + L Q + + F K + GDS
Sbjct: 1539 DGLVPGDLILEYGSLDVRNKTVEEV--YVEMLKPRDGVRLKVQYRPEEFTK-AKGLPGDS 1595
Query: 511 FYIRTHFELEPSPPSGLGFTRGDVFHVLDTLHPGPGQSHARGGHWLAVRMGRDLREQERG 570
FYIR ++ L F + D+ +V DTL G G W+A ++ + ++ +RG
Sbjct: 1596 FYIRALYDRLADVEQELSFKKDDILYVDDTLPQGTF------GSWMAWQLDENAQKIQRG 1649
Query: 571 IIPNQSRAEQLASLEAAQRAVGVGPGSSA--GSNARAEFWRLRGLRRGAKKTTQRSREDL 628
IP++ +Q S + V ++ + AR F+R + K++ + +DL
Sbjct: 1650 QIPSKYVMDQEFSRRLSMSEVKDDNSATKTLSAAARRSFFRRKHKH---KRSGSKDGKDL 1706
Query: 629 SALTR--QGRYP--------PYERVVLREASFKRPVVILGPVADIAMQKLTAEMPDQF-- 676
AL P Y+RV + + RPV+ILGP+ D+ + L E P +F
Sbjct: 1707 LALDAFSSDSIPLFEDSVSLAYQRVQKVDCTALRPVLILGPLLDVVKEMLVNEAPGKFCR 1766
Query: 677 ---EIAET----------------VSRTDSPSKIIKLDTVRVIAEKDKHALLDVTPSAIE 717
E+ + R + + +++ I EK++H LLD+ P AIE
Sbjct: 1767 CPLEVMKASQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITEKNRHCLLDIAPHAIE 1826
Query: 718 RLNYVQYYPIVVFFIPESRPALKALRQWL---APASRRSTRRLYAQAQKLRKHSSHLFTA 774
RL+++ YPIV+F +S +K R + ++R ++ + AQKL + S FT
Sbjct: 1827 RLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDKVTQRHSKEQFEAAQKLEQEYSRYFTG 1886
Query: 775 TIPLNGTSDTWYQELKAIIREQQTRPIW 802
I G + ++ A++ ++Q + +W
Sbjct: 1887 VIQ-GGALSSICTQILAMVNQEQNKVLW 1913
Score = 52.0 bits (123), Expect = 3e-06
Identities = 40/143 (27%), Positives = 69/143 (48%), Gaps = 17/143 (11%)
Query: 342 IPPPPRHAQR-------SPEASQTDSPVESPRLRRESSVDS-RTISEPDEQRSELPRESS 393
IP PR+ + S S+ +P +SP ++D+ + S+ S LPR +
Sbjct: 1276 IPSTPRYPRSVVGSERGSVSHSECSTPPQSPL-----NIDTLSSCSQSQTSASTLPRIA- 1329
Query: 394 YDIYRVPSSQSMEDRGYSPDTRVVRFLKGKS-IGLRLAGGNDVGIFVSGVQAGSPADGQG 452
+ + +DR Y + R V+ KG +G+ + G GI+VS V GS A G
Sbjct: 1330 --VNPASLGERRKDRPYVEEPRHVKVQKGSEPLGISIVSGEKGGIYVSKVTVGSIAHQAG 1387
Query: 453 IQEGDQILQVNDVPFQNLTREEA 475
++ GDQ+L+ N + ++ T ++A
Sbjct: 1388 LEYGDQLLEFNGINLRSATEQQA 1410
Score = 49.3 bits (116), Expect = 2e-05
Identities = 50/182 (27%), Positives = 86/182 (47%), Gaps = 30/182 (16%)
Query: 368 RRESSVDSRTISEPDEQ-RSELPRESSYDIYRVPSSQ--SMEDRGYSPDTRVVRFLKG-- 422
R++ + SR + E EQ S+L +E+ + SS +++ +T VV F +
Sbjct: 569 RKQKNDVSRELKELKEQMESQLEKEARFRQLMAHSSHDSAIDTDSMEWETEVVEFERETE 628
Query: 423 ----KSIGLRLAGG-------NDVGIFVSGVQAGSPADGQGIQEGDQILQVNDVPFQNLT 471
K++G +A G D GIFV+ V GS ADG+ ++ D +L++NDV N
Sbjct: 629 DIDLKALGFDMAEGVNEPCFPGDCGIFVTKVDKGSIADGR-LRVNDWLLRINDVDLINKD 687
Query: 472 REEAVQFLLGLPPGE-EMELVTQRKQDIFWKMVQSRVGDSFYIRTHFELEPSPPSGLGFT 530
+++A++ LL GE + +V +R++ + K+V H L SG+
Sbjct: 688 KKQAIKALLN---GEGAINMVVRRRKSLGGKVVTP---------LHINLSGQKDSGISLE 735
Query: 531 RG 532
G
Sbjct: 736 NG 737
Score = 41.2 bits (95), Expect = 0.005
Identities = 28/119 (23%), Positives = 54/119 (45%), Gaps = 8/119 (6%)
Query: 204 RQDVQMKPVKSVLVKRRDSEEFGVKLGSQIFIKHITDSGLAARHRGLQEGDLILQINGVS 263
R+ + K V + + ++ G+ L + ++ + AA+ L GD I+ ING++
Sbjct: 709 RKSLGGKVVTPLHINLSGQKDSGISLENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIA 768
Query: 264 SQNLSLNDTRRLIEKSEGKLSLLVLRDRGQFLVNIPPAVSDSDSSPLEEGVTMADEMSS 322
N SLN+ L+ + L+L +L+ + P S + E + +D+M S
Sbjct: 769 LDNKSLNECESLLRSCQDSLTLSLLK--------VFPQSSSWSGQNIFENIKDSDKMLS 819
Score = 37.4 bits (85), Expect = 0.067
Identities = 17/42 (40%), Positives = 27/42 (64%), Gaps = 2/42 (4%)
Query: 61 VVPGGPA--EGRLQTGDHIVMVNGVSMENATSAFAIQILKTC 100
V+PG PA EG L GD IV +NG++++N + +L++C
Sbjct: 743 VLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRSC 784
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 137 bits (346), Expect = 4e-32
Identities = 153/642 (23%), Positives = 255/642 (39%), Gaps = 160/642 (24%)
Query: 231 SQIFIKHITDSGLAARHRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRD 290
+ I++ I + G A + LQ GD +L +N V + ++ + ++ + + L V +
Sbjct: 346 NSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKP 405
Query: 291 RGQFLVN--IPPAVSDSDSSPLEEGVTMADEMSSPPADISDLASELSQAPPSHIPPPPRH 348
++ + PP +++S S P++ V SP +S L Q P S P R+
Sbjct: 406 TSMYMNDGYAPPDITNSSSQPVDNHV-------SP-------SSFLGQTPAS----PARY 447
Query: 349 AQRSPEASQTDSPVESPRLRRESSVDSRTISEPDEQRSELPRESSYDIYRVPSSQSMEDR 408
+ S D PR
Sbjct: 448 SPVSKAVLGDDEITREPR------------------------------------------ 465
Query: 409 GYSPDTRVVRFLKGKSIGLRLAGGND-VGIFVSGVQAGSPADGQG-IQEGDQILQVNDVP 466
+VV +G + GG D GIF+S + AG PAD G +++GD+I+ VN V
Sbjct: 466 ------KVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVD 519
Query: 467 FQNLTREEAVQFLLGLPPGEEMELVTQRK-----------QDIFWKMVQSRVGD------ 509
+ + E+A L G+ + +V Q + D+ +M+ S +
Sbjct: 520 LRAASHEQAAAALKNA--GQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLR 577
Query: 510 -----SFYIRTHFELEPS-----PPSGLGFTRGDVFHVLDTLHPGPGQSHARGGHWLAVR 559
S Y+R F+ + + P GL F GD+ HV++ + W A +
Sbjct: 578 TSQKRSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINA---------SDDEWWQARQ 628
Query: 560 MGRDLREQERGIIPNQSRAEQLASLEAAQRAVGVGPGSSAGSNARAEFWRLRGLRRGAKK 619
+ D E G+IP++ R E+ +RA ++ + + E G +G K
Sbjct: 629 VTPDGESDEVGVIPSKRRVEK------KERARLKTVKFNSKTRDKGEIPDDMG-SKGLKH 681
Query: 620 TTQRSREDLSALTRQGRYP-PYERVVLREASFKRPVVILGPVADIAMQKLTAEMPDQFEI 678
T + + S+ Q Y YE V +E ++ RPV+ILGP+ D L +E PD+F
Sbjct: 682 VTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKF-- 739
Query: 679 AETVSRTDSPSKIIKLD--------------------------------------TVRVI 700
V T P + ++D +VR +
Sbjct: 740 GSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREV 799
Query: 701 AEKDKHALLDVTPSAIERLNYVQYYPIVVFFIPESRPALKALRQWLAPASRRSTRRLYAQ 760
AEK KH +LDV+ +AI+RL Q YPI +F P+S + + + L + R+ + +
Sbjct: 800 AEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRL---TEEQARKTFER 856
Query: 761 AQKLRKHSSHLFTATIPLNGTSDTWYQELKAIIREQQTRPIW 802
A KL + + FTA + T + Y ++K II EQ IW
Sbjct: 857 AMKLEQEFTEHFTAIVQ-GDTLEDIYNQVKQIIEEQSGSYIW 897
Score = 47.8 bits (112), Expect = 5e-05
Identities = 29/95 (30%), Positives = 50/95 (52%), Gaps = 7/95 (7%)
Query: 26 WEQHTATLSKDPRRGFGIAISGGRDRP----GGSMVVSDVVPGGPA--EGRLQTGDHIVM 79
+E TL + G G +I+GG D P S+ ++ ++ GG A +GRL+ D I+
Sbjct: 220 YEYEEITLERG-NSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILR 278
Query: 80 VNGVSMENATSAFAIQILKTCTKMANITVKRPRRI 114
VN V + + T + A++ LK + + VKR + +
Sbjct: 279 VNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPV 313
Score = 47.8 bits (112), Expect = 5e-05
Identities = 32/97 (32%), Positives = 52/97 (53%), Gaps = 7/97 (7%)
Query: 33 LSKDPRRGFGIAISGG---RDRPG-GSMVVSDVVPGGPA--EGRLQTGDHIVMVNGVSME 86
L K P+ G G +I+GG + PG S+ V+ ++ GG A +G+LQ GD ++ VN V +E
Sbjct: 322 LIKGPK-GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLE 380
Query: 87 NATSAFAIQILKTCTKMANITVKRPRRIHLPATKASP 123
T A+ LK + + V +P +++ A P
Sbjct: 381 EVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPP 417
Score = 39.7 bits (91), Expect = 0.014
Identities = 26/72 (36%), Positives = 40/72 (55%), Gaps = 9/72 (12%)
Query: 417 VRFLKG-KSIGLRLAGG-------NDVGIFVSGVQAGSPADGQG-IQEGDQILQVNDVPF 467
++ +KG K +G +AGG D I+V+ + G A G +Q GD++L VN+V
Sbjct: 320 IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCL 379
Query: 468 QNLTREEAVQFL 479
+ +T EEAV L
Sbjct: 380 EEVTHEEAVTAL 391
>gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
Length = 817
Score = 133 bits (334), Expect = 9e-31
Identities = 160/640 (25%), Positives = 255/640 (39%), Gaps = 150/640 (23%)
Query: 231 SQIFIKHITDSGLAARHRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRD 290
+ I+I I + G A + LQ GD +L +N N +L D R E SL D
Sbjct: 253 NSIYITKIIEGGAAQKDGRLQIGDRLLAVN-----NTNLQDVRH----EEAVASLKNTSD 303
Query: 291 RGQFLVNIPPAVSDSDSSPLEEGVTMADEMSSPPADISDLASELSQAPPSHIPPPPRHAQ 350
V P G ++M +PP D AS + +HI H
Sbjct: 304 MVYLKVAKP-------------GSLHLNDMYAPP----DYASTFTALADNHIS----HNS 342
Query: 351 RSPEASQTDSPVESPRLRRESSVDSRTISEPDEQRSELPRESSYDIYRVPSSQSMEDRGY 410
+S V P + P + S +PR + + +
Sbjct: 343 SLGYLGAVESKVSYPAPPQV----------PPTRYSPIPRHM------------LAEEDF 380
Query: 411 SPDTRVVRFLKGKS-IGLRLAGGND-VGIFVSGVQAGSPADGQG-IQEGDQILQVNDVPF 467
+ + R + KG + +G + GG D GIFVS + AG PAD G ++ GD+IL VN V
Sbjct: 381 TREPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNL 440
Query: 468 QNLTREEAVQFLLGLPPGEEMELVTQRKQDIFWKMVQSRVGD------------------ 509
+N T E+A L G+ + +V Q + + + + +S++ D
Sbjct: 441 RNATHEQAAAALKRA--GQSVTIVAQYRPEEYSRF-ESKIHDLREQMMNSSMSSGSGSLR 497
Query: 510 -----SFYIRTHFELEPS-----PPSGLGFTRGDVFHVLDTLHPGPGQSHARGGHWLAVR 559
S Y+R F+ + + P GL F+ GD+ HV++ A W R
Sbjct: 498 TSEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVIN----------ASDDEWWQAR 547
Query: 560 MGRDLREQER-GIIPNQSRAEQLASLEAAQRAVGVGPGSSAGSNARAEFWRLRGLRRGAK 618
+ E E+ G+IP++ R E+ E A+ + + +F L GAK
Sbjct: 548 LVTPHGESEQIGVIPSKKRVEKK---ERARLKTVKFHARTGMIESNRDFPGLSDDYYGAK 604
Query: 619 KTTQRSREDLSALTRQGRYPPYERVVLREASFKRPVVILGPVADIAMQKLTAEMPDQF-- 676
+ LS YE V +E + RPV+ILGP+ D L +E P +F
Sbjct: 605 NLKGQEDAILS----------YEPVTRQEIHYARPVIILGPMKDRVNDDLISEFPHKFGS 654
Query: 677 ------------EI----------AETVSRTDSPSKIIK------------LDTVRVIAE 702
E+ E + + +K I+ + +VR +AE
Sbjct: 655 CVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAE 714
Query: 703 KDKHALLDVTPSAIERLNYVQYYPIVVFFIPESRPALKALRQWLAPASRRSTRRLYAQAQ 762
+ KH +LDV+ +AI+RL Q YPI +F P+S ++AL + + ++Y +A
Sbjct: 715 RGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKS---IEALMEMNRRQTYEQANKIYDKAM 771
Query: 763 KLRKHSSHLFTATIPLNGTSDTWYQELKAIIREQQTRPIW 802
KL + FTA + + + Y ++K II +Q IW
Sbjct: 772 KLEQEFGEYFTAIVQGDSLEEI-YNKIKQIIEDQSGHYIW 810
Score = 55.8 bits (133), Expect = 2e-07
Identities = 65/263 (24%), Positives = 110/263 (41%), Gaps = 38/263 (14%)
Query: 33 LSKDPRRGFGIAISGG---RDRPG-GSMVVSDVVPGGPAE--GRLQTGDHIVMVNGVSME 86
L K P+ G G +I+GG + PG S+ ++ ++ GG A+ GRLQ GD ++ VN +++
Sbjct: 229 LLKGPK-GLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQ 287
Query: 87 NATSAFAIQILKTCTKMANITVKRPRRIHLPATKASPSSPGRQDSDEDDGPQRVEEVDQG 146
+ A+ LK + M + V +P +HL A P + D+ +
Sbjct: 288 DVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISH----NSS 343
Query: 147 RGYDGDSSSGSGRSWDERSRRPRPGRRGRAGSHGRRSPGGGSEANGLALVSGFKRLPRQD 206
GY G + S S+ + P P R H L +D
Sbjct: 344 LGYLG--AVESKVSYPAPPQVP-PTRYSPIPRH---------------------MLAEED 379
Query: 207 VQMKPVKSVLVKRRDSEEF---GVKLGSQIFIKHITDSGLAARHRGLQEGDLILQINGVS 263
+P K +L K F G + G IF+ I G A L+ GD IL +NGV+
Sbjct: 380 FTREPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVN 439
Query: 264 SQNLSLNDTRRLIEKSEGKLSLL 286
+N + ++++ ++++
Sbjct: 440 LRNATHEQAAAALKRAGQSVTIV 462
Score = 47.8 bits (112), Expect = 5e-05
Identities = 29/72 (40%), Positives = 39/72 (54%), Gaps = 4/72 (5%)
Query: 40 GFGIAISGGRDRPGGSMVVSDVVPGGPAE--GRLQTGDHIVMVNGVSMENATSAFAIQIL 97
G G I GG D G + VS ++ GGPA+ G L+ GD I+ VNGV++ NAT A L
Sbjct: 395 GLGFNIVGGED--GEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAAL 452
Query: 98 KTCTKMANITVK 109
K + I +
Sbjct: 453 KRAGQSVTIVAQ 464
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 130 bits (326), Expect = 8e-30
Identities = 152/657 (23%), Positives = 255/657 (38%), Gaps = 168/657 (25%)
Query: 231 SQIFIKHITDSGLAARHRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRD 290
+ I++ I + G A + LQ GD +L +N V + ++ + ++ + + L V +
Sbjct: 346 NSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKP 405
Query: 291 RGQFLVN--IPPAVSDSDSSPLEEGVTMADEMSSPPADISDLASELSQAPPSHIPPPPRH 348
++ + PP +++S S P++ V SP +S L Q P S P R+
Sbjct: 406 TSMYMNDGYAPPDITNSSSQPVDNHV-------SP-------SSFLGQTPAS----PARY 447
Query: 349 AQRSPEASQTDSPVESPRLRRESSVDSRTISEPDEQRSELPRESSYDIYRVPSSQSMEDR 408
+ S D PR
Sbjct: 448 SPVSKAVLGDDEITREPR------------------------------------------ 465
Query: 409 GYSPDTRVVRFLKGKSIGLRLAGGND-VGIFVSGVQAGSPADGQG-IQEGDQILQVNDVP 466
+VV +G + GG D GIF+S + AG PAD G +++GD+I+ VN V
Sbjct: 466 ------KVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVD 519
Query: 467 FQNLTREEAVQFLLGLPPGEEMELVTQRK-----------QDIFWKMVQSRVGD------ 509
+ + E+A L G+ + +V Q + D+ +M+ S +
Sbjct: 520 LRAASHEQAAAALKNA--GQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLR 577
Query: 510 -----SFYIRTHFELEPS-----PPSGLGFTRGDVFHVLDTLHPGPGQSHARGGHWLAVR 559
S Y+R F+ + + P GL F GD+ HV++ + W A +
Sbjct: 578 TSQKRSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINA---------SDDEWWQARQ 628
Query: 560 MGRDLREQERGIIPNQSRAEQ-------LASLEAAQRAVGVGPGSSAGSNARA-EFWRLR 611
+ D E G+IP++ R E+ + R G N + +F +
Sbjct: 629 VTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGQSFNDKRKKNLFSRKFPFYK 688
Query: 612 GLRRGAKKT-------TQRSREDLSALTRQGRYP-PYERVVLREASFKRPVVILGPVADI 663
+ ++T T + + S+ Q Y YE V +E ++ RPV+ILGP+ D
Sbjct: 689 NKDQSEQETSDADQHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDR 748
Query: 664 AMQKLTAEMPDQFEIAETVSRTDSPSKIIKLD---------------------------- 695
L +E PD+F V T P + ++D
Sbjct: 749 INDDLISEFPDKF--GSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQY 806
Query: 696 ----------TVRVIAEKDKHALLDVTPSAIERLNYVQYYPIVVFFIPESRPALKALRQW 745
+VR +AEK KH +LDV+ +AI+RL Q YPI +F P+S + + +
Sbjct: 807 NNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKR 866
Query: 746 LAPASRRSTRRLYAQAQKLRKHSSHLFTATIPLNGTSDTWYQELKAIIREQQTRPIW 802
L + R+ + +A KL + + FTA + T + Y ++K II EQ IW
Sbjct: 867 L---TEEQARKTFERAMKLEQEFTEHFTAIVQ-GDTLEDIYNQVKQIIEEQSGSYIW 919
Score = 47.8 bits (112), Expect = 5e-05
Identities = 29/95 (30%), Positives = 50/95 (52%), Gaps = 7/95 (7%)
Query: 26 WEQHTATLSKDPRRGFGIAISGGRDRP----GGSMVVSDVVPGGPA--EGRLQTGDHIVM 79
+E TL + G G +I+GG D P S+ ++ ++ GG A +GRL+ D I+
Sbjct: 220 YEYEEITLERG-NSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILR 278
Query: 80 VNGVSMENATSAFAIQILKTCTKMANITVKRPRRI 114
VN V + + T + A++ LK + + VKR + +
Sbjct: 279 VNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPV 313
Score = 47.8 bits (112), Expect = 5e-05
Identities = 32/97 (32%), Positives = 52/97 (53%), Gaps = 7/97 (7%)
Query: 33 LSKDPRRGFGIAISGG---RDRPG-GSMVVSDVVPGGPA--EGRLQTGDHIVMVNGVSME 86
L K P+ G G +I+GG + PG S+ V+ ++ GG A +G+LQ GD ++ VN V +E
Sbjct: 322 LIKGPK-GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLE 380
Query: 87 NATSAFAIQILKTCTKMANITVKRPRRIHLPATKASP 123
T A+ LK + + V +P +++ A P
Sbjct: 381 EVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPP 417
Score = 39.7 bits (91), Expect = 0.014
Identities = 26/72 (36%), Positives = 40/72 (55%), Gaps = 9/72 (12%)
Query: 417 VRFLKG-KSIGLRLAGG-------NDVGIFVSGVQAGSPADGQG-IQEGDQILQVNDVPF 467
++ +KG K +G +AGG D I+V+ + G A G +Q GD++L VN+V
Sbjct: 320 IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCL 379
Query: 468 QNLTREEAVQFL 479
+ +T EEAV L
Sbjct: 380 EEVTHEEAVTAL 391
>gi|119943108 synapse-associated protein 102 isoform b [Homo
sapiens]
Length = 512
Score = 129 bits (325), Expect = 1e-29
Identities = 128/490 (26%), Positives = 211/490 (43%), Gaps = 110/490 (22%)
Query: 403 QSMEDRGYSPDTRVVRFLKGKS-IGLRLAGGND-VGIFVSGVQAGSPADGQG-IQEGDQI 459
+S+ G + + R + KG + +G + GG D GIFVS + AG PAD G ++ GD+I
Sbjct: 36 RSLRPGGDAREPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRI 95
Query: 460 LQVNDVPFQNLTREEAVQFLLGLPPGEEMELVTQRKQDIFWKMVQSRVGD---------- 509
L VN V +N T E+A L G+ + +V Q + + + + +S++ D
Sbjct: 96 LSVNGVNLRNATHEQAAAALKRA--GQSVTIVAQYRPEEYSRF-ESKIHDLREQMMNSSM 152
Query: 510 -------------SFYIRTHFELEPS-----PPSGLGFTRGDVFHVLDTLHPGPGQSHAR 551
S Y+R F+ + + P GL F+ GD+ HV++ A
Sbjct: 153 SSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVIN----------AS 202
Query: 552 GGHWLAVRMGRDLREQER-GIIPNQSRAE--QLASLEAAQRAVGVGPGSSAGSNARAEFW 608
W R+ E E+ G+IP++ R E + A L+ + G SN +
Sbjct: 203 DDEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHARTG---MIESNRSIKTK 259
Query: 609 RLRGLRRGAKKTTQRSREDL---SALTRQG-----------------RYPPYERVVLREA 648
R + R K +S+E++ S++ QG YE V +E
Sbjct: 260 RKKSFRLSRKFPFYKSKENMAQESSIQEQGVTSNTSDSESSSKGQEDAILSYEPVTRQEI 319
Query: 649 SFKRPVVILGPVADIAMQKLTAEMPDQF--------------EI----------AETVSR 684
+ RPV+ILGP+ D L +E P +F E+ E + +
Sbjct: 320 HYARPVIILGPMKDRVNDDLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEK 379
Query: 685 TDSPSKIIK------------LDTVRVIAEKDKHALLDVTPSAIERLNYVQYYPIVVFFI 732
+K I+ + +VR +AE+ KH +LDV+ +AI+RL Q YPI +F
Sbjct: 380 DIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIK 439
Query: 733 PESRPALKALRQWLAPASRRSTRRLYAQAQKLRKHSSHLFTATIPLNGTSDTWYQELKAI 792
P+S ++AL + + ++Y +A KL + FTA + + + Y ++K I
Sbjct: 440 PKS---IEALMEMNRRQTYEQANKIYDKAMKLEQEFGEYFTAIVQGDSLEEI-YNKIKQI 495
Query: 793 IREQQTRPIW 802
I +Q IW
Sbjct: 496 IEDQSGHYIW 505
Score = 47.8 bits (112), Expect = 5e-05
Identities = 29/72 (40%), Positives = 39/72 (54%), Gaps = 4/72 (5%)
Query: 40 GFGIAISGGRDRPGGSMVVSDVVPGGPAE--GRLQTGDHIVMVNGVSMENATSAFAIQIL 97
G G I GG D G + VS ++ GGPA+ G L+ GD I+ VNGV++ NAT A L
Sbjct: 58 GLGFNIVGGED--GEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAAL 115
Query: 98 KTCTKMANITVK 109
K + I +
Sbjct: 116 KRAGQSVTIVAQ 127
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 127 bits (320), Expect = 4e-29
Identities = 154/639 (24%), Positives = 244/639 (38%), Gaps = 175/639 (27%)
Query: 231 SQIFIKHITDSGLAARHRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRD 290
+ I++ I + G A + LQ GD IL +N V +++ D ++ + + L V +
Sbjct: 230 NSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKP 289
Query: 291 RGQFLVNIPPAVSDSDSSPLEEGVTMADEMSSPPADISDLASELSQAPPSHIPPPPRHAQ 350
+L SDS + P D+ + SQ + I
Sbjct: 290 SNAYL-------SDSYAPP-------------------DITTSYSQHLDNEISHSSYLGT 323
Query: 351 RSPEASQTDSPVESPRLRRESSVDSRTISEPDEQRSELPRESSYDIYRVPSSQSMEDRGY 410
P A SP RR S V + E D +PRE
Sbjct: 324 DYPTAMTPTSP------RRYSPVAKDLLGEED-----IPREPR----------------- 355
Query: 411 SPDTRVVRFLKGKSIGLRLAGGND-VGIFVSGVQAGSPADGQG-IQEGDQILQVNDVPFQ 468
R+V +G + GG D GIF+S + AG PAD G +++GDQIL VN V +
Sbjct: 356 ----RIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLR 411
Query: 469 NLTREEAVQFLLGLPPGEEMELVTQRK-----------QDIFWKMVQSRVGDS------- 510
N + E+A L G+ + ++ Q K D+ +++ S +G
Sbjct: 412 NASHEQAAIALKNA--GQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSN 469
Query: 511 ----FYIRTHFELEPSPPSG-----LGFTRGDVFHVLDTLHPGPGQSHARGGHWLAVRMG 561
FYIR F+ + + G L F GDV HV+D + W A R+
Sbjct: 470 PKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDA---------SDEEWWQARRVH 520
Query: 562 RDLREQERGIIPNQSRAEQLASLEAAQRAVGVGPGSSAGSNARAEFWRLRGLRRGAKKTT 621
D + G IP++ R E R E+ RL+ G+ +
Sbjct: 521 SDSETDDIGFIPSKRRVE------------------------RREWSRLKAKDWGSSSGS 556
Query: 622 QRSREDLSALTRQGRYPPYERVVLREASFKRPVVILGPVADIAMQKLTAEMPDQFEIAET 681
Q RED S L+ YE V E + RP++ILGP D A L +E PD+F
Sbjct: 557 Q-GRED-SVLS-------YETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKF--GSC 605
Query: 682 VSRTDSPSKIIKLD--------------------------------------TVRVIAEK 703
V T P + ++D +VR +AE+
Sbjct: 606 VPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQ 665
Query: 704 DKHALLDVTPSAIERLNYVQYYPIVVFFIPESRPALKALRQWLAPASRRSTRRLYAQAQK 763
KH +LDV+ +A+ RL +PI +F P S + + + + + R+ + +A K
Sbjct: 666 GKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRI---TEEQARKAFDRATK 722
Query: 764 LRKHSSHLFTATIPLNGTSDTWYQELKAIIREQQTRPIW 802
L + + F+A + + + Y ++K +I + IW
Sbjct: 723 LEQEFTECFSAIVE-GDSFEEIYHKVKRVIEDLSGPYIW 760
Score = 54.3 bits (129), Expect = 5e-07
Identities = 65/247 (26%), Positives = 94/247 (38%), Gaps = 49/247 (19%)
Query: 33 LSKDPRRGFGIAISGG---RDRPG-GSMVVSDVVPGGPA--EGRLQTGDHIVMVNGVSME 86
L K P+ G G +I+GG + PG S+ V+ ++ GG A +GRLQ GD I+ VN V +E
Sbjct: 206 LIKGPK-GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLE 264
Query: 87 NATSAFAIQILKTCTKMANITVKRPRRIHLPATKASPSSPGRQDSDEDDGPQRVEEVDQG 146
+ A+ LK + + V +P +L SD P Q
Sbjct: 265 DVMHEDAVAALKNTYDVVYLKVAKPSNAYL--------------SDSYAPPDITTSYSQH 310
Query: 147 RGYDGDSSSGSGRSWDERSRRPRPGRRGRAGSHGRRSPGGGSEANGLALVSGFKRLPRQD 206
+ SS G + P R L +D
Sbjct: 311 LDNEISHSSYLGTDYPTAMTPTSPRRYSPVAK---------------------DLLGEED 349
Query: 207 VQMKPVKSVLVKRRDSEEFGVKL-----GSQIFIKHITDSGLAARHRGLQEGDLILQING 261
+ +P + V+ R S G + G IFI I G A L++GD IL +NG
Sbjct: 350 IPREPRRIVI--HRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNG 407
Query: 262 VSSQNLS 268
V +N S
Sbjct: 408 VDLRNAS 414
Score = 48.1 bits (113), Expect = 4e-05
Identities = 26/77 (33%), Positives = 42/77 (54%), Gaps = 6/77 (7%)
Query: 40 GFGIAISGGRDRP----GGSMVVSDVVPGGPA--EGRLQTGDHIVMVNGVSMENATSAFA 93
G G +I+GG D P S+ ++ ++PGG A +GRL+ D I+ VN V + T + A
Sbjct: 117 GLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAA 176
Query: 94 IQILKTCTKMANITVKR 110
++ LK + + V R
Sbjct: 177 VEALKEAGSIVRLYVMR 193
Score = 45.8 bits (107), Expect = 2e-04
Identities = 30/84 (35%), Positives = 43/84 (51%), Gaps = 12/84 (14%)
Query: 33 LSKDPRR--------GFGIAISGGRDRPGGSMVVSDVVPGGPAE--GRLQTGDHIVMVNG 82
+ ++PRR G G I GG D G + +S ++ GGPA+ G L+ GD I+ VNG
Sbjct: 350 IPREPRRIVIHRGSTGLGFNIVGGED--GEGIFISFILAGGPADLSGELRKGDQILSVNG 407
Query: 83 VSMENATSAFAIQILKTCTKMANI 106
V + NA+ A LK + I
Sbjct: 408 VDLRNASHEQAAIALKNAGQTVTI 431
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 127 bits (320), Expect = 4e-29
Identities = 154/639 (24%), Positives = 244/639 (38%), Gaps = 175/639 (27%)
Query: 231 SQIFIKHITDSGLAARHRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRD 290
+ I++ I + G A + LQ GD IL +N V +++ D ++ + + L V +
Sbjct: 184 NSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKP 243
Query: 291 RGQFLVNIPPAVSDSDSSPLEEGVTMADEMSSPPADISDLASELSQAPPSHIPPPPRHAQ 350
+L SDS + P D+ + SQ + I
Sbjct: 244 SNAYL-------SDSYAPP-------------------DITTSYSQHLDNEISHSSYLGT 277
Query: 351 RSPEASQTDSPVESPRLRRESSVDSRTISEPDEQRSELPRESSYDIYRVPSSQSMEDRGY 410
P A SP RR S V + E D +PRE
Sbjct: 278 DYPTAMTPTSP------RRYSPVAKDLLGEED-----IPREPR----------------- 309
Query: 411 SPDTRVVRFLKGKSIGLRLAGGND-VGIFVSGVQAGSPADGQG-IQEGDQILQVNDVPFQ 468
R+V +G + GG D GIF+S + AG PAD G +++GDQIL VN V +
Sbjct: 310 ----RIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLR 365
Query: 469 NLTREEAVQFLLGLPPGEEMELVTQRK-----------QDIFWKMVQSRVGDS------- 510
N + E+A L G+ + ++ Q K D+ +++ S +G
Sbjct: 366 NASHEQAAIALKNA--GQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSN 423
Query: 511 ----FYIRTHFELEPSPPSG-----LGFTRGDVFHVLDTLHPGPGQSHARGGHWLAVRMG 561
FYIR F+ + + G L F GDV HV+D + W A R+
Sbjct: 424 PKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDA---------SDEEWWQARRVH 474
Query: 562 RDLREQERGIIPNQSRAEQLASLEAAQRAVGVGPGSSAGSNARAEFWRLRGLRRGAKKTT 621
D + G IP++ R E R E+ RL+ G+ +
Sbjct: 475 SDSETDDIGFIPSKRRVE------------------------RREWSRLKAKDWGSSSGS 510
Query: 622 QRSREDLSALTRQGRYPPYERVVLREASFKRPVVILGPVADIAMQKLTAEMPDQFEIAET 681
Q RED S L+ YE V E + RP++ILGP D A L +E PD+F
Sbjct: 511 Q-GRED-SVLS-------YETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKF--GSC 559
Query: 682 VSRTDSPSKIIKLD--------------------------------------TVRVIAEK 703
V T P + ++D +VR +AE+
Sbjct: 560 VPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQ 619
Query: 704 DKHALLDVTPSAIERLNYVQYYPIVVFFIPESRPALKALRQWLAPASRRSTRRLYAQAQK 763
KH +LDV+ +A+ RL +PI +F P S + + + + + R+ + +A K
Sbjct: 620 GKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRI---TEEQARKAFDRATK 676
Query: 764 LRKHSSHLFTATIPLNGTSDTWYQELKAIIREQQTRPIW 802
L + + F+A + + + Y ++K +I + IW
Sbjct: 677 LEQEFTECFSAIVE-GDSFEEIYHKVKRVIEDLSGPYIW 714
Score = 54.3 bits (129), Expect = 5e-07
Identities = 65/247 (26%), Positives = 94/247 (38%), Gaps = 49/247 (19%)
Query: 33 LSKDPRRGFGIAISGG---RDRPG-GSMVVSDVVPGGPA--EGRLQTGDHIVMVNGVSME 86
L K P+ G G +I+GG + PG S+ V+ ++ GG A +GRLQ GD I+ VN V +E
Sbjct: 160 LIKGPK-GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLE 218
Query: 87 NATSAFAIQILKTCTKMANITVKRPRRIHLPATKASPSSPGRQDSDEDDGPQRVEEVDQG 146
+ A+ LK + + V +P +L SD P Q
Sbjct: 219 DVMHEDAVAALKNTYDVVYLKVAKPSNAYL--------------SDSYAPPDITTSYSQH 264
Query: 147 RGYDGDSSSGSGRSWDERSRRPRPGRRGRAGSHGRRSPGGGSEANGLALVSGFKRLPRQD 206
+ SS G + P R L +D
Sbjct: 265 LDNEISHSSYLGTDYPTAMTPTSPRRYSPVAK---------------------DLLGEED 303
Query: 207 VQMKPVKSVLVKRRDSEEFGVKL-----GSQIFIKHITDSGLAARHRGLQEGDLILQING 261
+ +P + V+ R S G + G IFI I G A L++GD IL +NG
Sbjct: 304 IPREPRRIVI--HRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNG 361
Query: 262 VSSQNLS 268
V +N S
Sbjct: 362 VDLRNAS 368
Score = 48.1 bits (113), Expect = 4e-05
Identities = 26/77 (33%), Positives = 42/77 (54%), Gaps = 6/77 (7%)
Query: 40 GFGIAISGGRDRP----GGSMVVSDVVPGGPA--EGRLQTGDHIVMVNGVSMENATSAFA 93
G G +I+GG D P S+ ++ ++PGG A +GRL+ D I+ VN V + T + A
Sbjct: 71 GLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAA 130
Query: 94 IQILKTCTKMANITVKR 110
++ LK + + V R
Sbjct: 131 VEALKEAGSIVRLYVMR 147
Score = 45.8 bits (107), Expect = 2e-04
Identities = 30/84 (35%), Positives = 43/84 (51%), Gaps = 12/84 (14%)
Query: 33 LSKDPRR--------GFGIAISGGRDRPGGSMVVSDVVPGGPAE--GRLQTGDHIVMVNG 82
+ ++PRR G G I GG D G + +S ++ GGPA+ G L+ GD I+ VNG
Sbjct: 304 IPREPRRIVIHRGSTGLGFNIVGGED--GEGIFISFILAGGPADLSGELRKGDQILSVNG 361
Query: 83 VSMENATSAFAIQILKTCTKMANI 106
V + NA+ A LK + I
Sbjct: 362 VDLRNASHEQAAIALKNAGQTVTI 385
>gi|218156270 chapsyn-110 isoform 4 [Homo sapiens]
Length = 334
Score = 100 bits (250), Expect = 5e-21
Identities = 90/336 (26%), Positives = 138/336 (41%), Gaps = 71/336 (21%)
Query: 510 SFYIRTHFELEPS-----PPSGLGFTRGDVFHVLDTLHPGPGQSHARGGHWLAVRMGRDL 564
S Y+R F+ + S P GL F GD+ HV++ + W A R+ +
Sbjct: 20 SLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINA---------SDDEWWQARRVMLEG 70
Query: 565 REQERGIIPNQSRAEQLASLEAAQRAVGVGPGSSAGSNARAEFWRLRGLRRGAKKTTQRS 624
+E G+IP++ R E+ PG +++ + L G K T R
Sbjct: 71 DSEEMGVIPSKRRVERKERARLKTVKFNAKPGVI---DSKGDIPGLGDDGYGTK--TLRG 125
Query: 625 REDLSALTRQGRYPPYERVVLREASFKRPVVILGPVADIAMQKLTAEMPDQFEIAETVSR 684
+EDL YE V +E ++ RPV+ILGP+ D L +E PD+F V
Sbjct: 126 QEDLIL--------SYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKF--GSCVPH 175
Query: 685 TDSPSKIIKLD--------------------------------------TVRVIAEKDKH 706
T P + ++D +VR +AE+ KH
Sbjct: 176 TTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKH 235
Query: 707 ALLDVTPSAIERLNYVQYYPIVVFFIPESRPALKALRQWLAPASRRSTRRLYAQAQKLRK 766
+LDV+ +AI+RL Q YPI +F P S L + + L + ++ Y +A KL +
Sbjct: 236 CILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRL---TEEQAKKTYDRAIKLEQ 292
Query: 767 HSSHLFTATIPLNGTSDTWYQELKAIIREQQTRPIW 802
FTA + T + Y + K +I EQ IW
Sbjct: 293 EFGEYFTAIVQ-GDTLEDIYNQCKLVIEEQSGPFIW 327
>gi|38570142 membrane protein, palmitoylated 5 [Homo sapiens]
Length = 675
Score = 81.6 bits (200), Expect = 3e-15
Identities = 112/551 (20%), Positives = 212/551 (38%), Gaps = 105/551 (19%)
Query: 310 LEEGVTMADEMSSPPADISDLASELSQAPPSHIPPPPRHAQRSPEASQTDSPVESPRLRR 369
+ +T+ +SPP + A +L+Q + + P E + + + +P ++
Sbjct: 165 IHNAITVHMNKASPPFPLISNAQDLAQEVQTVLKPV-----HHKEGQELTALLNTPHIQA 219
Query: 370 ESSVDSRTISEPDEQRSELPRESSYDIYRVPSSQSMEDRGYSPDTRVVRFLKGKSIGLRL 429
+ ++E + Q + E Y+ +++ ++VR K + I L
Sbjct: 220 LLLAHDK-VAEQEMQLEPITDERVYESIGQYGGETV---------KIVRIEKARDIPLGA 269
Query: 430 AGGNDV-GIFVSGVQAGSPADGQGI-QEGDQILQVNDVPFQNLTREEAVQFLLGLPPGEE 487
N++ + +S + G A+ G+ EGD++L++N + + E L +
Sbjct: 270 TVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLT 329
Query: 488 MELVTQRKQDIFWKMVQSRVGDSFYIRTHFELEPSPPS-------GLGFTRGDVFHVLDT 540
L+ Q I + V +++ HF+ +PS GL F +GD+ HV+
Sbjct: 330 FVLIPS--QQIKPPPAKETV---IHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQ 384
Query: 541 LHPGPGQSHARGGHWLAVRMGRDLREQERGIIPNQSRAEQLASLEAAQRAVGVGPGSSAG 600
P W A R G + + G++P +S +Q EA ++ +
Sbjct: 385 EDP---------NWWQAYREGDEDNQPLAGLVPGKSFQQQ---REAMKQTI----EEDKE 428
Query: 601 SNARAEFWRLRGLRRGAKKTTQRSREDLSALTRQGRYPPYERVVLREASF-------KRP 653
+ W AKK ++ ++ L + Y E + E S KRP
Sbjct: 429 PEKSGKLW-------CAKKNKKKRKKVLYNANKNDDYDNEEILTYEEMSLYHQPANRKRP 481
Query: 654 VVILGPV---ADIAMQKLTAEMPDQFEIA---ETVSRTD--------------------S 687
++++GP + Q+L + D+F A T SR D +
Sbjct: 482 IILIGPQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVSRQAFEADIA 541
Query: 688 PSKIIK------------LDTVRVIAEKDKHALLDVTPSAIERLNYVQYYPIVVFFIPES 735
K I+ +D+VR + K LL + +++ L P ++F P S
Sbjct: 542 AGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPPS 601
Query: 736 RPALKALRQWLAPASR----RSTRRLYAQAQKLRKHSSHLFTATIPLNGTSDTWYQELKA 791
+ L+AL LA + R + + +++ +++ H F I +N D YQEL
Sbjct: 602 QERLRAL---LAKEGKNPKPEELREIIEKTREMEQNNGHYFDTAI-VNSDLDKAYQELLR 657
Query: 792 IIREQQTRPIW 802
+I + T P W
Sbjct: 658 LINKLDTEPQW 668
Score = 36.2 bits (82), Expect = 0.15
Identities = 28/128 (21%), Positives = 56/128 (43%), Gaps = 23/128 (17%)
Query: 194 ALVSGFKRLPRQDVQMKP-----------------VKSVLVKRRDSEEFGVKLGSQ---I 233
AL+ ++ Q++Q++P VK V +++ G + ++ +
Sbjct: 219 ALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGATVRNEMDSV 278
Query: 234 FIKHITDSGLAARHRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRDRGQ 293
I I G A + L EGD +L+ING+ + +N+ L+ G L+ +++ +
Sbjct: 279 IISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQ-- 336
Query: 294 FLVNIPPA 301
+ PPA
Sbjct: 337 -QIKPPPA 343
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 78.6 bits (192), Expect = 3e-14
Identities = 109/514 (21%), Positives = 205/514 (39%), Gaps = 63/514 (12%)
Query: 27 EQHTATLSKDPRRGFGIAISGGRDRPGGSMVVSDVVPGGP--AEGRLQTGDHIVMVNGVS 84
E H L KD + G G++++G +DR S+ V + P GP A+GR++ GD ++ +N
Sbjct: 1236 ELHIIELEKD-KNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQI 1294
Query: 85 MENATSAFAIQILKTC-TKMANITVKRPRRIH------LPATKASPSSPGRQDSDEDDGP 137
+ + A I+KT +K+ + ++ ++ P +SPSS Q E
Sbjct: 1295 LYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISS 1354
Query: 138 QRVEEVDQGRGYDGDSSSGSGRSWDERSRRPRPGRRGRAGSHGRRSPGGGSEANGLALV- 196
+ V+ G +S S + + ++ P + + +P +
Sbjct: 1355 EEDGSVEVGIKQLPESESFK-LAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTG 1413
Query: 197 -SGFKRLPRQDVQMKPV----KSVLVKRRDSEEFGVKLG-------SQIFIKHITDSGLA 244
GF+ D P+ + ++ + G+ + + I I + + G A
Sbjct: 1414 YGGFQAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAA 1473
Query: 245 ARHRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRDRGQF-----LVNIP 299
AR L GD IL++NGV +N S + + ++ K+ L+V RD + L P
Sbjct: 1474 ARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFP 1533
Query: 300 PAVSDSDSSPL---------EEGVTMADEMSSPPADISDLASELSQAPPSHIPPPPRHAQ 350
+ L GV ++D + AD+ + Q + +Q
Sbjct: 1534 VDLQKKAGRGLGLSIVGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQ 1593
Query: 351 RSP----EASQTDSPVESPRLRRESSVDSRTISEPDEQRSELPRESSYDIY--------- 397
+ + +Q +E RLR S +RT S+ + + S + +
Sbjct: 1594 ETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQN 1653
Query: 398 ----RVPSSQSMEDRGYSPDTRVVRFLK--GKSIGLRLAGG-----NDVGIFVSGVQA-G 445
+ S S ++ G + R V + ++G+ +AGG D+ +F++ +QA G
Sbjct: 1654 LVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASG 1713
Query: 446 SPADGQGIQEGDQILQVNDVPFQNLTREEAVQFL 479
A Q ++ GD+I+ +N P L+ + V L
Sbjct: 1714 VAARTQKLKVGDRIVSINGQPLDGLSHADVVNLL 1747
Score = 74.3 bits (181), Expect = 5e-13
Identities = 79/288 (27%), Positives = 115/288 (39%), Gaps = 67/288 (23%)
Query: 19 DMEELTIWEQHTATLSKDPRRGFGIAISGGRDRPGGSMVVSDVVPGGPAE--GRLQTGDH 76
D E L I+ L K RG G++I G R+ G + +SD+V GG A+ GRL GD
Sbjct: 1525 DEENLEIFP---VDLQKKAGRGLGLSIVGKRN--GSGVFISDIVKGGAADLDGRLIQGDQ 1579
Query: 77 IVMVNGVSMENATSAFAIQILKTCTKMANITVKRPRRIHLPATKASPSSPGRQDSDEDDG 136
I+ VNG M NA+ ILK + + + R R A + R S G
Sbjct: 1580 ILSVNGEDMRNASQETVATILKCAQGLVQLEIGRLR--------AGSWTSARTTSQNSQG 1631
Query: 137 PQRVEEVDQGRGYDGDSSSGSGRSWDERSRRPRPGRRGRAGSHGRRSPGGGSEANGLALV 196
Q+ +H P GL +
Sbjct: 1632 SQQ-------------------------------------SAHSSCHPSFAPVITGLQNL 1654
Query: 197 SGFKRL--PRQ---DVQMKPVKSVLVKRRDSEEFGVKLGS---------QIFIKHITDSG 242
G KR+ P Q M+P ++V + R S+ G+ + +FI I SG
Sbjct: 1655 VGTKRVSDPSQKNSGTDMEP-RTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASG 1713
Query: 243 LAARHRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRD 290
+AAR + L+ GD I+ ING LS D L++ + G++ L V+ D
Sbjct: 1714 VAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVAD 1761
Score = 56.6 bits (135), Expect = 1e-07
Identities = 107/494 (21%), Positives = 188/494 (38%), Gaps = 78/494 (15%)
Query: 35 KDPRRGFGIAISGG-----RDRPGGSM---VVSDVVPGGPA--EGRLQTGDHIVMVNGVS 84
++P GI+I GG R + G + + V+ PA L+TGD I+ V+GV
Sbjct: 1073 REPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVD 1132
Query: 85 MENATSAFAIQILKTCTKMANITVKR----PRRIHLPATKASPSSPGRQDSDEDDGPQRV 140
++NA+ + A++ +K V+ PR I KA+ + G Q+ D Q
Sbjct: 1133 LQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKIT-GNQNQDT----QEK 1187
Query: 141 EEVDQGRGYDGDSSSGSGRSWDERSRRPRPGRRGRAGSHGRRSPGGGSEANGLALVSGFK 200
+E QG + P P + S ++ +
Sbjct: 1188 KEKRQGTA-------------PPPMKLPPPYKALTDDSDENEEEDAFTD----------Q 1224
Query: 201 RLPRQDVQMKPVKSVLVKRRDSEEFGVKLGSQ-------IFIKHITDSGLAARHRGLQEG 253
++ ++ + ++ +D G+ L IF+ I G AA ++ G
Sbjct: 1225 KIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIG 1284
Query: 254 DLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRDR---GQFLVNIPPAVSDSDSSPL 310
D +L+IN S + +I+ + K+ L+ +R+ Q V P S S SS
Sbjct: 1285 DELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSS-- 1342
Query: 311 EEGVTMADEMSSPPADISDLASELSQAPPSHIPPPPRHAQRSPEASQTDSPVESPRLRRE 370
+ D+ + P +S + + S S ++ + +
Sbjct: 1343 -----IEDQSGTEP---------ISSEEDGSVEVGIKQLPESESFKLAVSQMKQQKYPTK 1388
Query: 371 SSVDSRTI--SEPDEQRSELPRESSYDIYRVPSSQSMEDRGYSPDTR-VVRFLKGKS-IG 426
S S+ I + S + Y ++ P S P ++ KG+S +G
Sbjct: 1389 VSFSSQEIPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIVPGQEMIIEISKGRSGLG 1448
Query: 427 LRLAGGNDV---GIFVSGV-QAGSPADGQGIQEGDQILQVNDVPFQNLTREEAVQFLLGL 482
L + GG D I + V + G+ A + GDQIL+VN V +N + EEA+ L
Sbjct: 1449 LSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQT 1508
Query: 483 PPGEEMELVTQRKQ 496
P +++ LV R +
Sbjct: 1509 P--QKVRLVVYRDE 1520
Score = 56.2 bits (134), Expect = 1e-07
Identities = 31/88 (35%), Positives = 47/88 (53%), Gaps = 5/88 (5%)
Query: 40 GFGIAISGGRDRPGGSMVVSDVVPGGPAE--GRLQTGDHIVMVNGVSMENATSAFAIQIL 97
G G I GG+ +VV +VPGG A+ GRLQTGDHI+ + G +++ TS Q+L
Sbjct: 257 GLGFGIVGGKT---SGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVL 313
Query: 98 KTCTKMANITVKRPRRIHLPATKASPSS 125
+ C + V R + T +P++
Sbjct: 314 RNCGNSVRMLVARDPAGDISVTPPAPAA 341
Score = 55.8 bits (133), Expect = 2e-07
Identities = 115/519 (22%), Positives = 200/519 (38%), Gaps = 109/519 (21%)
Query: 40 GFGIAISGGRDRPGGSMVVSDVVPGGPAEG--RLQTGDHIVMVNGVSME-NATSAFAIQI 96
GF + ++ + V DV PG A+ RL+ D I+ +N ++ N + AI +
Sbjct: 146 GFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAIAL 205
Query: 97 LKTCTKMANITVKRPRRIHLPATKASPSSPGRQDSDEDD----GPQRVEEVDQGRGYDGD 152
L+ T + V R +H TK+S SS + + + VE ++ G G G
Sbjct: 206 LQQTTGSLRLIVAR-EPVH---TKSSTSSSLNDTTLPETVCWGHVEEVELINDGSGL-GF 260
Query: 153 SSSGSGRSWDERSRRPRPGRRGRAGSHGRRSPG------GGSEANGL------------- 193
G G++ R PG G A GR G GG+ G+
Sbjct: 261 GIVG-GKTSGVVVRTIVPG--GLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCG 317
Query: 194 ---------------------------ALVSGFKRLPRQDVQMKPVKSVLVKRRDSEEFG 226
AL + + P D + +V + R+D + G
Sbjct: 318 NSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLG 377
Query: 227 VKL-----------GSQIFIKHITDSGLAARHRG-LQEGDLILQINGVSSQNLSLNDTRR 274
+++ S I++K I G AA H G +Q D I+ ++GV+ Q + +D
Sbjct: 378 IRIVGYVGTSHTGEASGIYVKSIIP-GSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVE 436
Query: 275 LIEKSEGKLSLLVLRDRGQFLVNIPPAVSDSDSSPLEEGVTMADEMSSPPADISDLASEL 334
++ + + L ++R + + S +SPLE PP+D + L
Sbjct: 437 VLRNAGQVVHLTLVRRK-----------TSSSTSPLE-----------PPSDRGTVVEPL 474
Query: 335 SQAPPSHIPPPPRHAQRSPEASQTDSPVESPRLRRESSVDSRTISE-PDEQRSELPRESS 393
PP+ + + + + L+ ++ + + PD +EL +S
Sbjct: 475 K--PPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENEL--KSR 530
Query: 394 YDIYRVPSSQSME---DRGYSPDTRVVRFLKGKSIG-LRLA---GGNDVGIFVSGVQAGS 446
++ P + M D + D + ++ K I LRL D ++S + +G
Sbjct: 531 WENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGG 590
Query: 447 PADGQGI-QEGDQILQVNDVPFQNLTREEAVQFLLGLPP 484
P D G+ Q D++L+VN + +R EAV FL +PP
Sbjct: 591 PVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPP 629
Score = 41.2 bits (95), Expect = 0.005
Identities = 33/124 (26%), Positives = 57/124 (45%), Gaps = 14/124 (11%)
Query: 374 DSRTISEPDEQRSELPRESSYDIYRVPSSQSMEDRG----YSPDTRVVRFLKG-KSIGLR 428
D ++ EP + LP E+ D + + + +D G +SP+ ++V +K K +G
Sbjct: 642 DEASVDEPRRTETSLP-ETEVD-HNMDVNTEEDDDGELALWSPEVKIVELVKDCKGLGFS 699
Query: 429 LAGGND-------VGIFVSGVQAGSPADGQGIQEGDQILQVNDVPFQNLTREEAVQFLLG 481
+ D V + S V G G+ GD+++ VN+ N + EAV+ L
Sbjct: 700 ILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKA 759
Query: 482 LPPG 485
+PPG
Sbjct: 760 VPPG 763
Score = 38.1 bits (87), Expect = 0.039
Identities = 30/102 (29%), Positives = 51/102 (50%), Gaps = 10/102 (9%)
Query: 199 FKRLPRQDVQMKPVKSVLVKRRDSEEFG---VKLGSQ------IFIKHITDSGLAARHRG 249
F + +Q Q + ++ + ++R + G V L SQ IF+K + +A R +
Sbjct: 119 FNSVIQQMAQGRQIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQR 178
Query: 250 LQEGDLILQINGVS-SQNLSLNDTRRLIEKSEGKLSLLVLRD 290
L+E D IL IN QN+S L++++ G L L+V R+
Sbjct: 179 LKENDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVARE 220
Score = 34.7 bits (78), Expect = 0.44
Identities = 32/87 (36%), Positives = 45/87 (51%), Gaps = 8/87 (9%)
Query: 19 DMEELTIW--EQHTATLSKDPRRGFGIAISGGRDR--PGGSMVV-SDVVPGGPAE--GRL 71
D EL +W E L KD + G G +I +D P S++V +V G AE G L
Sbjct: 673 DDGELALWSPEVKIVELVKDCK-GLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGL 731
Query: 72 QTGDHIVMVNGVSMENATSAFAIQILK 98
GD +V VN ++N + A A++ILK
Sbjct: 732 LPGDRLVSVNEYCLDNTSLAEAVEILK 758
>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform c [Homo sapiens]
Length = 1462
Score = 78.6 bits (192), Expect = 3e-14
Identities = 118/474 (24%), Positives = 193/474 (40%), Gaps = 74/474 (15%)
Query: 39 RGFGIAISGGRDRPGGSMVVSDVVPGGPA--EGRLQTGDHIVMVNGVSMENATSAFAIQI 96
RGFG + GG D P + + +V GPA +G+++TGD IV VN + T A ++I
Sbjct: 480 RGFGFTVVGG-DEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKI 538
Query: 97 LKTCTKMANITVKRPRRIHLPATKASPSSPGRQDSDEDDGPQRVEEVDQGRGYDGDSSSG 156
++ A++ ++ R LP P++ D + + SS
Sbjct: 539 FQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSK 598
Query: 157 SGRSWDERSRRPR-PGRRGRAGSHGRRSPGGGSEANGLALVSGFKRLPRQDVQMKPVKSV 215
+G+ + RP P SHG + + ++L S P + + VK
Sbjct: 599 TGKVNGMKDARPSSPADVASNSSHGYPN-------DTVSLASSIATQPEL-ITVHIVKGP 650
Query: 216 LVKRRDSEEFGVKL-----GSQIFIKHITDSGLAARHRGLQEGDLILQINGVSSQNLSLN 270
+ FG + G +K I DS R RGL+EGDLI+++N + Q L+ N
Sbjct: 651 M-------GFGFTIADSPGGGGQRVKQIVDS---PRCRGLKEGDLIVEVNKKNVQALTHN 700
Query: 271 D-TRRLIEKSEG-KLSLLVLRDRGQFLVNIPPAVSDSDSSPLEEGVTMADEMSSPPADIS 328
L+E +G +++LLV R +P S PLE D +S +S
Sbjct: 701 QVVDMLVECPKGSEVTLLVQRG------GLPVPKKSPKSQPLER----KDSQNSSQHSVS 750
Query: 329 DLASELSQAPPSH----IPPPPRHAQRSPEASQTDSPVESPRLRRESSVDSRTISEPDEQ 384
S L A PSH +P P ++P+ QTDS + +PD
Sbjct: 751 SHRS-LHTASPSHSTQVLPEFPPAEAQAPD--QTDSSGQ---------------KKPDPF 792
Query: 385 RSELPRESSYDIYRVPSSQSMEDRGYSPDTRVVRFLKGKSIGLRLAGGNDVG--IFVSGV 442
+ S Y+ R+P Q + + + K G R+ GGN+ G I++ +
Sbjct: 793 KIWAQSRSMYE-NRLPDYQEQD---------IFLWRKETGFGFRILGGNEPGEPIYIGHI 842
Query: 443 QAGSPADGQG-IQEGDQILQVNDVPFQNLTREEAVQFLLGLPPGEEMELVTQRK 495
AD G ++ GD+++ V+ P + + VQ + + L +RK
Sbjct: 843 VPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRK 896
Score = 72.4 bits (176), Expect = 2e-12
Identities = 103/476 (21%), Positives = 181/476 (38%), Gaps = 114/476 (23%)
Query: 21 EELTIWEQHTATLSKDPRRGFGIAISGGRDRPGGSMVVSDVVPGGPAE--GRLQTGDHIV 78
+++ +W + T GFG I GG + PG + + +VP G A+ GRL++GD ++
Sbjct: 812 QDIFLWRKET---------GFGFRILGGNE-PGEPIYIGHIVPLGAADTDGRLRSGDELI 861
Query: 79 MVNGVSMENATSAFAIQILKTCTKM--ANITVKRPRRIHLPATKASPSSPGRQDSDEDDG 136
V+G + + +Q+++ K N+TV+R +P T+ SP +
Sbjct: 862 CVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQP 921
Query: 137 PQRVEEVDQGRGYDGDSSSGSGRSWDERSRRPRPGRRGRAGSHGRRSPGGGSEANGLALV 196
EE +G ++ S G + G S GGG +V
Sbjct: 922 ASLTEEKRTPQGSQNSLNTVSS---------------GSGSTSGIGSGGGGGSGVVSTVV 966
Query: 197 SGFKRLPRQDVQMKPVKS-----VLVKRRDSEEFGVKLGSQIF-----IKHITDSGLAAR 246
+ DV+++ ++ V+V E G G+ I I + A R
Sbjct: 967 QPY------DVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADR 1020
Query: 247 HRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRDRGQFLVNIPPAVSDSD 306
L+ GD IL +NG S N S +D LI+++ ++L ++
Sbjct: 1021 CGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRII------------------ 1062
Query: 307 SSPLEEGVTMADEMSSPPADISDLASELSQAPPSHIPPPPRHAQRSPEASQTDSPVESPR 366
DE S+ A + A +++ +H P Q + E T P
Sbjct: 1063 ---------PGDESSN--ATLLTNAEKIATITTTHTP----SQQGTQETRNTTKP----- 1102
Query: 367 LRRESSVDSRTISEPDEQRSELPRESSYDIYRVPSSQSMEDRGYSPDTRVVRFLKGKSIG 426
++ES + + EQ D Y V +RG K G
Sbjct: 1103 -KQESQFEFKAPQATQEQ----------DFYTVEL-----ERG------------AKGFG 1134
Query: 427 LRLAGGND--VGIFVSGVQAGSPADGQG-IQEGDQILQVNDVPFQNLTREEAVQFL 479
L GG + + ++V + PA+ G ++ GD+IL++N +N+ A++ +
Sbjct: 1135 FSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELI 1190
Score = 45.8 bits (107), Expect = 2e-04
Identities = 43/153 (28%), Positives = 66/153 (43%), Gaps = 14/153 (9%)
Query: 39 RGFGIAISGGRDRPGGSMVVSDVVPGGPAE--GRLQTGDHIVMVNGVSMENATSAFAIQI 96
+GFG ++ GGR+ + V + GPAE G+++ GD I+ +NG + +N + AI++
Sbjct: 1131 KGFGFSLRGGREY-NMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIEL 1189
Query: 97 LKTCTKMANITVKRPRRIHLPATKASPSSPGRQDSDEDDGPQRVEEVDQGRGYDGDSSSG 156
+K + + +KR + PSS + GPQ V EV G S
Sbjct: 1190 IKNGGRRVRLFLKRGDG---SVPEYDPSSDRHGPA---TGPQGVPEVRAGPDRRQHPSLE 1243
Query: 157 SGRSWDERSRRPRPGRRGRAGSHGRRSPGGGSE 189
S D P +R A R P G E
Sbjct: 1244 SSYPPDLHKSSPHGEKRAHA-----RDPKGSRE 1271
Score = 43.9 bits (102), Expect = 7e-04
Identities = 113/495 (22%), Positives = 189/495 (38%), Gaps = 98/495 (19%)
Query: 30 TATLSKDPRRGFGIAISGGRDRPGGSMVVSDVVPGGPAEGRLQTGDHIVMVNGVSMENAT 89
T + K P GFG I+ D PGG + P L+ GD IV VN +++ T
Sbjct: 643 TVHIVKGPM-GFGFTIA---DSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALT 698
Query: 90 SAFAIQILKTCTKMANITVKRPRRIHLPATKASPSSPGRQDSDEDDGPQRVEEVDQGRGY 149
+ +L C K + +T+ +R LP K SP S + D + Q V R
Sbjct: 699 HNQVVDMLVECPKGSEVTL-LVQRGGLPVPKKSPKSQPLERKDSQNSSQ--HSVSSHRSL 755
Query: 150 DGDSSSGSGRSWDE----RSRRPRPGRRGRAGSHGRRSPGGGS-EANGLALVSGFKRLPR 204
S S S + E ++ P + S G++ P A ++ RLP
Sbjct: 756 HTASPSHSTQVLPEFPPAEAQAP-----DQTDSSGQKKPDPFKIWAQSRSMYE--NRLPD 808
Query: 205 QDVQMKPVKSVLVKRRDSEEFGVKL------GSQIFIKHITDSGLAARHRGLQEGDLILQ 258
Q + + R+++ FG ++ G I+I HI G A L+ GD ++
Sbjct: 809 YQEQ-----DIFLWRKET-GFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELIC 862
Query: 259 INGVSSQNLSLNDTRRLIEKS--EGKLSLLVLRDRGQFLVNIPPAVSDSDSSPLEEGVTM 316
++G S +L++++ +G ++L V R +V P + SP
Sbjct: 863 VDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRK----VVFAVPKTENEVPSP-----AS 913
Query: 317 ADEMSSPPADISDLASELSQAPPSHIPPPPRHAQRSPEASQTDSPVESPRLRRESSVDS- 375
+ S+ PA +++ +R+P+ SQ S S + S
Sbjct: 914 SHHSSNQPASLTE-------------------EKRTPQGSQNSLNTVSSGSGSTSGIGSG 954
Query: 376 --------RTISEPDEQRSELPRESSYDIYRVPSSQSMEDRGYSPDTRVVRFLKGKSIG- 426
T+ +P YD+ + ++ E G+ + V R G + G
Sbjct: 955 GGGGSGVVSTVVQP------------YDV-EIRRGEN-EGFGFVIVSSVSRPEAGTTFGN 1000
Query: 427 LRLAGGNDVGIFVSGVQAGSPADGQG-IQEGDQILQVNDVPFQNLTREEAVQFL------ 479
+A + +G + GSPAD G ++ GD+IL VN N + + V +
Sbjct: 1001 ACVAMPHKIGRIIE----GSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNT 1056
Query: 480 --LGLPPGEEMELVT 492
L + PG+E T
Sbjct: 1057 VTLRIIPGDESSNAT 1071
Score = 31.2 bits (69), Expect = 4.8
Identities = 35/144 (24%), Positives = 60/144 (41%), Gaps = 10/144 (6%)
Query: 350 QRSPEASQTDSPVESPRLRRESSVDSRTISEPDEQRSELPRESSYDIYRVPSSQSMEDRG 409
Q+ + QT+ E + + S P+ R E+P + R PS E +G
Sbjct: 414 QQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPAR-EVPLQGKPFFTRNPS----ELKG 468
Query: 410 YSPDTRVVRFLKGKSIGLRLAGGNDVGIFV---SGVQAGSPADGQGIQEGDQILQVNDVP 466
T++ + +G G + GG++ F+ S V G A ++ GD I+ VND
Sbjct: 469 KFIHTKLRKSSRG--FGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTC 526
Query: 467 FQNLTREEAVQFLLGLPPGEEMEL 490
T + V+ +P G ++L
Sbjct: 527 VLGHTHAQVVKIFQSIPIGASVDL 550
>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform b [Homo sapiens]
Length = 1256
Score = 77.0 bits (188), Expect = 8e-14
Identities = 119/484 (24%), Positives = 197/484 (40%), Gaps = 66/484 (13%)
Query: 39 RGFGIAISGGRDRPGGSMVVSDVVPGGPA--EGRLQTGDHIVMVNGVSMENATSAFAIQI 96
RGFG + GG D P + + +V GPA +G+++TGD IV VN + T A ++I
Sbjct: 480 RGFGFTVVGG-DEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKI 538
Query: 97 LKTCTKMANITVKRPRRIHLPATKASPSSPGRQDSDEDDGPQRVEEVDQGRGYDGDSSSG 156
++ A++ ++ R LP P++ D + + SS
Sbjct: 539 FQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSK 598
Query: 157 SGRSWDERSRRPR-PGRRGRAGSHGRRSPGGGSEANGLALVSGFKRLPRQDVQMKPVKSV 215
+G+ + RP P SHG + + ++L S P + + VK
Sbjct: 599 TGKVNGMKDARPSSPADVASNSSHGYPN-------DTVSLASSIATQPEL-ITVHIVKGP 650
Query: 216 LVKRRDSEEFGVKL-----GSQIFIKHITDSGLAARHRGLQEGDLILQINGVSSQNLSLN 270
+ FG + G +K I DS R RGL+EGDLI+++N + Q L+ N
Sbjct: 651 M-------GFGFTIADSPGGGGQRVKQIVDS---PRCRGLKEGDLIVEVNKKNVQALTHN 700
Query: 271 D-TRRLIEKSEG-KLSLLVLRDRGQFLVNIPPAVSDSDSSPLEEGVTMADEMSSPPADIS 328
L+E +G +++LLV R +P S PLE D +S +S
Sbjct: 701 QVVDMLVECPKGSEVTLLVQRG------GLPVPKKSPKSQPLER----KDSQNSSQHSVS 750
Query: 329 DLASELSQAPPSH----IPP-PPRHAQRSPEASQTDSPVESP---RLRRESSVDSRTIS- 379
S L A PSH +P PP AQ + + P + S ++R +S
Sbjct: 751 SHRS-LHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMSP 809
Query: 380 EPDEQRSELPRE-----SSYDIYRVPSSQSMEDRGYSPDTRVVRFLKGKSIGLRLAGGND 434
P S+ RE +++ +P Q + + + K G R+ GGN+
Sbjct: 810 SPASGLSKGEREREINSTNFGECPIPDYQEQD---------IFLWRKETGFGFRILGGNE 860
Query: 435 VG--IFVSGVQAGSPADGQG-IQEGDQILQVNDVPFQNLTREEAVQFLLGLPPGEEMELV 491
G I++ + AD G ++ GD+++ V+ P + + VQ + + L
Sbjct: 861 PGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLT 920
Query: 492 TQRK 495
+RK
Sbjct: 921 VRRK 924
Score = 70.1 bits (170), Expect = 9e-12
Identities = 102/485 (21%), Positives = 179/485 (36%), Gaps = 131/485 (27%)
Query: 21 EELTIWEQHTATLSKDPRRGFGIAISGGRDRPGGSMVVSDVVPGGPAE--GRLQTGDHIV 78
+++ +W + T GFG I GG + PG + + +VP G A+ GRL++GD ++
Sbjct: 840 QDIFLWRKET---------GFGFRILGGNE-PGEPIYIGHIVPLGAADTDGRLRSGDELI 889
Query: 79 MVNGVSMENATSAFAIQILKTCTKM--ANITVKRPRRIHLPATKASPSSPGRQDSDEDDG 136
V+G + + +Q+++ K N+TV+R +P T+ SP +
Sbjct: 890 CVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQP 949
Query: 137 PQRVEEVDQGRGYDGDSSSGSGRSWDERSRRPRPGRRGRAGSHGRRSPGGGSEANGLALV 196
EE +G ++ S G + G S GGG +V
Sbjct: 950 ASLTEEKRTPQGSQNSLNTVSS---------------GSGSTSGIGSGGGGGSGVVSTVV 994
Query: 197 SGFKRLPRQDVQMKPVKSVLVKRRDSEEFGVKLGSQIF-------------------IKH 237
+ V ++R ++E FG + S + I
Sbjct: 995 QPY--------------DVEIRRGENEGFGFVIVSSVSRPEAGTTFAGNACVAMPHKIGR 1040
Query: 238 ITDSGLAARHRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRDRGQFLVN 297
I + A R L+ GD IL +NG S N S +D LI+++ ++L ++
Sbjct: 1041 IIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRII--------- 1091
Query: 298 IPPAVSDSDSSPLEEGVTMADEMSSPPADISDLASELSQAPPSHIPPPPRHAQRSPEASQ 357
DE S+ A + A +++ +H P Q + E
Sbjct: 1092 ------------------PGDESSN--ATLLTNAEKIATITTTHTP----SQQGTQETRN 1127
Query: 358 TDSPVESPRLRRESSVDSRTISEPDEQRSELPRESSYDIYRVPSSQSMEDRGYSPDTRVV 417
T P ++ES + + EQ D Y V +RG
Sbjct: 1128 TTKP------KQESQFEFKAPQATQEQ----------DFYTVEL-----ERG-------- 1158
Query: 418 RFLKGKSIGLRLAGGND--VGIFVSGVQAGSPADGQG-IQEGDQILQVNDVPFQNLTREE 474
K G L GG + + ++V + PA+ G ++ GD+IL++N +N+
Sbjct: 1159 ----AKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSR 1214
Query: 475 AVQFL 479
A++ +
Sbjct: 1215 AIELI 1219
Score = 48.1 bits (113), Expect = 4e-05
Identities = 115/515 (22%), Positives = 191/515 (37%), Gaps = 109/515 (21%)
Query: 30 TATLSKDPRRGFGIAISGGRDRPGGSMVVSDVVPGGPAEGRLQTGDHIVMVNGVSMENAT 89
T + K P GFG I+ D PGG + P L+ GD IV VN +++ T
Sbjct: 643 TVHIVKGPM-GFGFTIA---DSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALT 698
Query: 90 SAFAIQILKTCTKMANITVKRPRRIHLPATKASPSSPGRQDSDEDDGPQRVEEVDQGRGY 149
+ +L C K + +T+ +R LP K SP S + D + Q V R
Sbjct: 699 HNQVVDMLVECPKGSEVTL-LVQRGGLPVPKKSPKSQPLERKDSQNSSQ--HSVSSHRSL 755
Query: 150 DGDSSSGSGRSWDE---------------RSRRPRPGR-RGRAGSHGRRSPGGGSEANGL 193
S S S + E ++P P + ++ S P S A+GL
Sbjct: 756 HTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGL 815
Query: 194 AL--------VSGFKRLPRQDVQMKPVKSVLVKRRDSEEFGVKL------GSQIFIKHIT 239
+ + F P D Q + + + R+++ FG ++ G I+I HI
Sbjct: 816 SKGEREREINSTNFGECPIPDYQ---EQDIFLWRKET-GFGFRILGGNEPGEPIYIGHIV 871
Query: 240 DSGLAARHRGLQEGDLILQINGVSSQNLSLNDTRRLIEKS--EGKLSLLVLRDRGQFLVN 297
G A L+ GD ++ ++G S +L++++ +G ++L V R +V
Sbjct: 872 PLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRK----VVF 927
Query: 298 IPPAVSDSDSSPLEEGVTMADEMSSPPADISDLASELSQAPPSHIPPPPRHAQRSPEASQ 357
P + SP + S+ PA +++ +R+P+ SQ
Sbjct: 928 AVPKTENEVPSP-----ASSHHSSNQPASLTE-------------------EKRTPQGSQ 963
Query: 358 TDSPVESPRLRRESSVDS---------RTISEPDEQRSELPRESSYDIYRVPSSQSMEDR 408
S S + S T+ +P YD+ + E+
Sbjct: 964 NSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQP------------YDV----EIRRGENE 1007
Query: 409 GYSPDTRVVRFLKGKSIGLRLAGGNDVGI--FVSGVQAGSPADGQG-IQEGDQILQVNDV 465
G+ +V + G AG V + + + GSPAD G ++ GD+IL VN
Sbjct: 1008 GFG--FVIVSSVSRPEAGTTFAGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGC 1065
Query: 466 PFQNLTREEAVQFL--------LGLPPGEEMELVT 492
N + + V + L + PG+E T
Sbjct: 1066 SITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNAT 1100
Score = 42.7 bits (99), Expect = 0.002
Identities = 23/74 (31%), Positives = 43/74 (58%), Gaps = 3/74 (4%)
Query: 39 RGFGIAISGGRDRPGGSMVVSDVVPGGPAE--GRLQTGDHIVMVNGVSMENATSAFAIQI 96
+GFG ++ GGR+ + V + GPAE G+++ GD I+ +NG + +N + AI++
Sbjct: 1160 KGFGFSLRGGREY-NMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIEL 1218
Query: 97 LKTCTKMANITVKR 110
+K + + +KR
Sbjct: 1219 IKNGGRRVRLFLKR 1232
Score = 31.2 bits (69), Expect = 4.8
Identities = 35/144 (24%), Positives = 60/144 (41%), Gaps = 10/144 (6%)
Query: 350 QRSPEASQTDSPVESPRLRRESSVDSRTISEPDEQRSELPRESSYDIYRVPSSQSMEDRG 409
Q+ + QT+ E + + S P+ R E+P + R PS E +G
Sbjct: 414 QQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPAR-EVPLQGKPFFTRNPS----ELKG 468
Query: 410 YSPDTRVVRFLKGKSIGLRLAGGNDVGIFV---SGVQAGSPADGQGIQEGDQILQVNDVP 466
T++ + +G G + GG++ F+ S V G A ++ GD I+ VND
Sbjct: 469 KFIHTKLRKSSRG--FGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTC 526
Query: 467 FQNLTREEAVQFLLGLPPGEEMEL 490
T + V+ +P G ++L
Sbjct: 527 VLGHTHAQVVKIFQSIPIGASVDL 550
>gi|74272282 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform a [Homo sapiens]
Length = 1287
Score = 77.0 bits (188), Expect = 8e-14
Identities = 119/484 (24%), Positives = 197/484 (40%), Gaps = 66/484 (13%)
Query: 39 RGFGIAISGGRDRPGGSMVVSDVVPGGPA--EGRLQTGDHIVMVNGVSMENATSAFAIQI 96
RGFG + GG D P + + +V GPA +G+++TGD IV VN + T A ++I
Sbjct: 480 RGFGFTVVGG-DEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKI 538
Query: 97 LKTCTKMANITVKRPRRIHLPATKASPSSPGRQDSDEDDGPQRVEEVDQGRGYDGDSSSG 156
++ A++ ++ R LP P++ D + + SS
Sbjct: 539 FQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSK 598
Query: 157 SGRSWDERSRRPR-PGRRGRAGSHGRRSPGGGSEANGLALVSGFKRLPRQDVQMKPVKSV 215
+G+ + RP P SHG + + ++L S P + + VK
Sbjct: 599 TGKVNGMKDARPSSPADVASNSSHGYPN-------DTVSLASSIATQPEL-ITVHIVKGP 650
Query: 216 LVKRRDSEEFGVKL-----GSQIFIKHITDSGLAARHRGLQEGDLILQINGVSSQNLSLN 270
+ FG + G +K I DS R RGL+EGDLI+++N + Q L+ N
Sbjct: 651 M-------GFGFTIADSPGGGGQRVKQIVDS---PRCRGLKEGDLIVEVNKKNVQALTHN 700
Query: 271 D-TRRLIEKSEG-KLSLLVLRDRGQFLVNIPPAVSDSDSSPLEEGVTMADEMSSPPADIS 328
L+E +G +++LLV R +P S PLE D +S +S
Sbjct: 701 QVVDMLVECPKGSEVTLLVQRG------GLPVPKKSPKSQPLER----KDSQNSSQHSVS 750
Query: 329 DLASELSQAPPSH----IPP-PPRHAQRSPEASQTDSPVESP---RLRRESSVDSRTIS- 379
S L A PSH +P PP AQ + + P + S ++R +S
Sbjct: 751 SHRS-LHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMSP 809
Query: 380 EPDEQRSELPRE-----SSYDIYRVPSSQSMEDRGYSPDTRVVRFLKGKSIGLRLAGGND 434
P S+ RE +++ +P Q + + + K G R+ GGN+
Sbjct: 810 SPASGLSKGEREREINSTNFGECPIPDYQEQD---------IFLWRKETGFGFRILGGNE 860
Query: 435 VG--IFVSGVQAGSPADGQG-IQEGDQILQVNDVPFQNLTREEAVQFLLGLPPGEEMELV 491
G I++ + AD G ++ GD+++ V+ P + + VQ + + L
Sbjct: 861 PGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLT 920
Query: 492 TQRK 495
+RK
Sbjct: 921 VRRK 924
Score = 72.4 bits (176), Expect = 2e-12
Identities = 103/476 (21%), Positives = 181/476 (38%), Gaps = 114/476 (23%)
Query: 21 EELTIWEQHTATLSKDPRRGFGIAISGGRDRPGGSMVVSDVVPGGPAE--GRLQTGDHIV 78
+++ +W + T GFG I GG + PG + + +VP G A+ GRL++GD ++
Sbjct: 840 QDIFLWRKET---------GFGFRILGGNE-PGEPIYIGHIVPLGAADTDGRLRSGDELI 889
Query: 79 MVNGVSMENATSAFAIQILKTCTKM--ANITVKRPRRIHLPATKASPSSPGRQDSDEDDG 136
V+G + + +Q+++ K N+TV+R +P T+ SP +
Sbjct: 890 CVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQP 949
Query: 137 PQRVEEVDQGRGYDGDSSSGSGRSWDERSRRPRPGRRGRAGSHGRRSPGGGSEANGLALV 196
EE +G ++ S G + G S GGG +V
Sbjct: 950 ASLTEEKRTPQGSQNSLNTVSS---------------GSGSTSGIGSGGGGGSGVVSTVV 994
Query: 197 SGFKRLPRQDVQMKPVKS-----VLVKRRDSEEFGVKLGSQIF-----IKHITDSGLAAR 246
+ DV+++ ++ V+V E G G+ I I + A R
Sbjct: 995 QPY------DVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADR 1048
Query: 247 HRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRDRGQFLVNIPPAVSDSD 306
L+ GD IL +NG S N S +D LI+++ ++L ++
Sbjct: 1049 CGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRII------------------ 1090
Query: 307 SSPLEEGVTMADEMSSPPADISDLASELSQAPPSHIPPPPRHAQRSPEASQTDSPVESPR 366
DE S+ A + A +++ +H P Q + E T P
Sbjct: 1091 ---------PGDESSN--ATLLTNAEKIATITTTHTP----SQQGTQETRNTTKP----- 1130
Query: 367 LRRESSVDSRTISEPDEQRSELPRESSYDIYRVPSSQSMEDRGYSPDTRVVRFLKGKSIG 426
++ES + + EQ D Y V +RG K G
Sbjct: 1131 -KQESQFEFKAPQATQEQ----------DFYTVEL-----ERG------------AKGFG 1162
Query: 427 LRLAGGND--VGIFVSGVQAGSPADGQG-IQEGDQILQVNDVPFQNLTREEAVQFL 479
L GG + + ++V + PA+ G ++ GD+IL++N +N+ A++ +
Sbjct: 1163 FSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELI 1218
Score = 45.8 bits (107), Expect = 2e-04
Identities = 116/514 (22%), Positives = 194/514 (37%), Gaps = 108/514 (21%)
Query: 30 TATLSKDPRRGFGIAISGGRDRPGGSMVVSDVVPGGPAEGRLQTGDHIVMVNGVSMENAT 89
T + K P GFG I+ D PGG + P L+ GD IV VN +++ T
Sbjct: 643 TVHIVKGPM-GFGFTIA---DSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALT 698
Query: 90 SAFAIQILKTCTKMANITVKRPRRIHLPATKASPSSPGRQDSDEDDGPQRVEEVDQGRGY 149
+ +L C K + +T+ +R LP K SP S + D + Q V R
Sbjct: 699 HNQVVDMLVECPKGSEVTL-LVQRGGLPVPKKSPKSQPLERKDSQNSSQ--HSVSSHRSL 755
Query: 150 DGDSSSGSGRSWDE---------------RSRRPRPGR-RGRAGSHGRRSPGGGSEANGL 193
S S S + E ++P P + ++ S P S A+GL
Sbjct: 756 HTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGL 815
Query: 194 AL--------VSGFKRLPRQDVQMKPVKSVLVKRRDSEEFGVKL------GSQIFIKHIT 239
+ + F P D Q + + + R+++ FG ++ G I+I HI
Sbjct: 816 SKGEREREINSTNFGECPIPDYQ---EQDIFLWRKET-GFGFRILGGNEPGEPIYIGHIV 871
Query: 240 DSGLAARHRGLQEGDLILQINGVSSQNLSLNDTRRLIEKS--EGKLSLLVLRDRGQFLVN 297
G A L+ GD ++ ++G S +L++++ +G ++L V R +V
Sbjct: 872 PLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRK----VVF 927
Query: 298 IPPAVSDSDSSPLEEGVTMADEMSSPPADISDLASELSQAPPSHIPPPPRHAQRSPEASQ 357
P + SP + S+ PA +++ +R+P+ SQ
Sbjct: 928 AVPKTENEVPSP-----ASSHHSSNQPASLTE-------------------EKRTPQGSQ 963
Query: 358 TDSPVESPRLRRESSVDS---------RTISEPDEQRSELPRESSYDIYRVPSSQSMEDR 408
S S + S T+ +P YD+ + ++ E
Sbjct: 964 NSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQP------------YDV-EIRRGEN-EGF 1009
Query: 409 GYSPDTRVVRFLKGKSIG-LRLAGGNDVGIFVSGVQAGSPADGQG-IQEGDQILQVNDVP 466
G+ + V R G + G +A + +G + GSPAD G ++ GD+IL VN
Sbjct: 1010 GFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIE----GSPADRCGKLKVGDRILAVNGCS 1065
Query: 467 FQNLTREEAVQFL--------LGLPPGEEMELVT 492
N + + V + L + PG+E T
Sbjct: 1066 ITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNAT 1099
Score = 42.7 bits (99), Expect = 0.002
Identities = 23/74 (31%), Positives = 43/74 (58%), Gaps = 3/74 (4%)
Query: 39 RGFGIAISGGRDRPGGSMVVSDVVPGGPAE--GRLQTGDHIVMVNGVSMENATSAFAIQI 96
+GFG ++ GGR+ + V + GPAE G+++ GD I+ +NG + +N + AI++
Sbjct: 1159 KGFGFSLRGGREY-NMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIEL 1217
Query: 97 LKTCTKMANITVKR 110
+K + + +KR
Sbjct: 1218 IKNGGRRVRLFLKR 1231
Score = 31.2 bits (69), Expect = 4.8
Identities = 35/144 (24%), Positives = 60/144 (41%), Gaps = 10/144 (6%)
Query: 350 QRSPEASQTDSPVESPRLRRESSVDSRTISEPDEQRSELPRESSYDIYRVPSSQSMEDRG 409
Q+ + QT+ E + + S P+ R E+P + R PS E +G
Sbjct: 414 QQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPAR-EVPLQGKPFFTRNPS----ELKG 468
Query: 410 YSPDTRVVRFLKGKSIGLRLAGGNDVGIFV---SGVQAGSPADGQGIQEGDQILQVNDVP 466
T++ + +G G + GG++ F+ S V G A ++ GD I+ VND
Sbjct: 469 KFIHTKLRKSSRG--FGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTC 526
Query: 467 FQNLTREEAVQFLLGLPPGEEMEL 490
T + V+ +P G ++L
Sbjct: 527 VLGHTHAQVVKIFQSIPIGASVDL 550
>gi|27436957 membrane associated guanylate kinase, WW and PDZ domain
containing 2 [Homo sapiens]
Length = 1455
Score = 75.5 bits (184), Expect = 2e-13
Identities = 120/490 (24%), Positives = 187/490 (38%), Gaps = 112/490 (22%)
Query: 40 GFGIAISGGRDRPGGSMVVSDVVPGGPAE--GRLQTGDHIVMVNGVSMENATSAFAIQIL 97
GFG I GG D PG +++ V+ G A+ GRL GD +V V+G+ + T + I ++
Sbjct: 787 GFGFRILGG-DEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLM 845
Query: 98 KTCTK--MANITVKRPRRIHLPATKASPSSPGRQDSDEDDGPQRVEEVDQGRGYDGDSSS 155
+ N+TV+R + SPG S
Sbjct: 846 HHAARNGQVNLTVRRKVLCGGEPCPENGRSPG---------------------------S 878
Query: 156 GSGRSWDERSRRPRPGRRGRAGSHGRRSPGGGSEANGLALVSGFKRLPRQDVQMKPVKSV 215
S RS A SP G ++ L V
Sbjct: 879 VSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASHSLQ-----------------TSDV 921
Query: 216 LVKRRDSEEFGVKL---------GSQIFIKH----ITDSGLAARHRGLQEGDLILQINGV 262
++ R+++E FG + GS I + H I D A R L+ GD IL +NG
Sbjct: 922 VIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQ 981
Query: 263 SSQNLSLNDTRRLIEKSEGKLSLLVLRDRGQFLVNIPPAVSDSDS-SPLEEGVTMADEMS 321
S N+ D +LI+ + ++L ++ Q +N P + S+ SP+ +
Sbjct: 982 SIINMPHADIVKLIKDAGLSVTLRIIP---QEELNSPTSAPSSEKQSPMAQ--------Q 1030
Query: 322 SPPADISDLASELSQAPPSHI--PPPPRHAQRSPEASQTDSPVES-----PRLRRESSVD 374
SP A S LA P S I P PP+ Q + S V++ P +R+ D
Sbjct: 1031 SPLAQQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTD 1090
Query: 375 SRTISEPDEQRSELPRESSYDI-----YRVPSSQSMEDRGYSPDTR-------------- 415
R P + R P Y YR P ++ R +SPDTR
Sbjct: 1091 YR--QPPLDYRQ--PPGGDYQQPPPLDYRQPPL--LDYRQHSPDTRQYPLSDYRQPQDFD 1144
Query: 416 --VVRFLKG-KSIGLRLAGGND--VGIFVSGVQAGSPADGQG-IQEGDQILQVNDVPFQN 469
V KG K G + GG + + ++V + PA G ++ GDQI+++N ++
Sbjct: 1145 YFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRD 1204
Query: 470 LTREEAVQFL 479
+T A++ +
Sbjct: 1205 MTHARAIELI 1214
Score = 68.2 bits (165), Expect = 4e-11
Identities = 114/482 (23%), Positives = 190/482 (39%), Gaps = 63/482 (13%)
Query: 31 ATLSKDPRRGFGIAISGGRDRPGGSMVVSDVVPGGPA--EGRLQTGDHIVMVNGVSMENA 88
+T K GFG I GG D P + V V+P GPA +G+++TGD IV +N V +
Sbjct: 426 STTLKKSNMGFGFTIIGG-DEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGH 484
Query: 89 TSAFAIQILKTCTKMANITVKRPRRIHLPATKASPSSPGRQDSDEDDGPQRVEEVDQGRG 148
T A +++ ++ ++ + R LP P++ P + E
Sbjct: 485 THADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVP-------PLAIMERPPPVM 537
Query: 149 YDGDSSSGSGRSWDERSRRPRPGRRGRAGSHGRRSPGGGSEANGLALVSGFKRLPRQDVQ 208
+G + + + R+ + P R P G + G P D
Sbjct: 538 VNGRHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQ-------LDGTYPPPVHDDN 590
Query: 209 MKPVKSVLVKRRDSEEFGVKLGSQIFIKHITDSGLAARHR---------GLQEGDLILQI 259
+ S + VK G+Q F I DS R + GL EGDLI++I
Sbjct: 591 VSMASSGATQAELMTLTIVK-GAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEI 649
Query: 260 NGVSSQNLSLNDTRRLIEKSE-GKLSLLVLRDRGQFLVNIPPAVSDSDSSPLEEGVTMAD 318
N + QNLS + +++ G + L++ G F SP + + D
Sbjct: 650 NQQNVQNLSHTEVVDILKDCPIGSETSLIIHRGGFF-------------SPWKTPKPIMD 696
Query: 319 EMSSPPADISDLASELSQAPPSHIP-PPPRHAQRSPEASQTDSPVESPRLRRESSVDSRT 377
+ + + L+ + A P ++P PP H P++++ P + E SR
Sbjct: 697 RWENQGSPQTSLS---APAIPQNLPFPPALHRSSFPDSTEAFDPRKPDPY--ELYEKSRA 751
Query: 378 ISEPDEQRSELPRESSYDIYRVPSSQSMEDRGYSP-DTRVVRFLKGKSIGLRLAGGNDVG 436
I E R ++P +S +R+ SS Y D + R G G R+ GG++ G
Sbjct: 752 IY---ESRQQVPPRTS---FRMDSS----GPDYKELDVHLRRMESG--FGFRILGGDEPG 799
Query: 437 --IFVSGVQAGSPADGQG-IQEGDQILQVNDVPFQNLTREEAVQFLLGLPPGEEMELVTQ 493
I + V A AD G + GD+++ V+ +P T + + ++ L +
Sbjct: 800 QPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVR 859
Query: 494 RK 495
RK
Sbjct: 860 RK 861
Score = 47.0 bits (110), Expect = 8e-05
Identities = 39/134 (29%), Positives = 61/134 (45%), Gaps = 11/134 (8%)
Query: 39 RGFGIAISGGRDRPGGSMVVSDVVPGGPA--EGRLQTGDHIVMVNGVSMENATSAFAIQI 96
+GFG +I GGR+ + V + GPA GR++ GD I+ +NG S + T A AI++
Sbjct: 1155 KGFGFSIRGGREYKM-DLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIEL 1213
Query: 97 LKTCTKMANITVKRPR----RIHLPATKASP--SSPGRQD--SDEDDGPQRVEEVDQGRG 148
+K+ + + +KR PA +SP ++PG + DDG
Sbjct: 1214 IKSGGRRVRLLLKRGTGQVPEYDEPAPWSSPAAAAPGLPEVGVSLDDGLAPFSPSHPAPP 1273
Query: 149 YDGDSSSGSGRSWD 162
D G +WD
Sbjct: 1274 SDPSHQISPGPTWD 1287
Score = 38.9 bits (89), Expect = 0.023
Identities = 28/109 (25%), Positives = 49/109 (44%), Gaps = 10/109 (9%)
Query: 33 LSKDPRRGFGIAISGGRDRP-GGSMV-----VSDVVPGGPAE--GRLQTGDHIVMVNGVS 84
+ + GFG I +RP GS + + ++ G PA+ +L+ GD I+ VNG S
Sbjct: 923 IHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQS 982
Query: 85 MENATSAFAIQILKTCTKMANITVKRPRRIHLP--ATKASPSSPGRQDS 131
+ N A ++++K + + ++ P A + SP Q S
Sbjct: 983 IINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQS 1031
>gi|111154074 palmitoylated membrane protein 7 [Homo sapiens]
Length = 576
Score = 70.5 bits (171), Expect = 7e-12
Identities = 107/477 (22%), Positives = 186/477 (38%), Gaps = 89/477 (18%)
Query: 391 ESSYDIYRVPSSQSMEDRGYSPDTRVVRFLKGKS-IGLRLAGGNDVG-IFVSGVQAGSPA 448
+ +YD P + ++D S +++R +K + +G + G I V+ + G A
Sbjct: 116 QKNYDPVLPPMPEDIDDEEDS--VKIIRLVKNREPLGATIKKDEQTGAIIVARIMRGGAA 173
Query: 449 DGQG-IQEGDQILQVNDVPFQNLTREEAVQFLLGLPPGEEMELVTQRKQDIFWKMVQSRV 507
D G I GD++ +VN +P ++ EE +Q L +++ K++ S+
Sbjct: 174 DRSGLIHVGDELREVNGIPVEDKRPEEIIQILAQSQGAITFKIIPGSKEE-----TPSKE 228
Query: 508 GDSFYIRTHFELEPS-------PPSGLGFTRGDVFHVLDTLHPGPGQSHARGGHWLAVRM 560
G F I+ F+ P+ +GL F +GD+ ++ Q A W +
Sbjct: 229 GKMF-IKALFDYNPNEDKAIPCKEAGLSFKKGDILQIM-------SQDDAT---WWQAKH 277
Query: 561 GRDLREQERGIIPNQSRAEQLASLEAAQRAVGVGPGSSAGSNARAEFWRLRGLRRGAKKT 620
D + G+IP++ E+ +L + V S+ S+ + +R L R KKT
Sbjct: 278 EADANPR-AGLIPSKHFQERRLALRRPEILVQPLKVSNRKSSGFRKSFR---LSRKDKKT 333
Query: 621 TQRSRE-DLSALTRQGRYPPYERVV--LREASFK-RPVVILGPVADIAMQKLTAEM--PD 674
+ E S P YE V R+ + K R VV++GPV + + +L ++ D
Sbjct: 334 NKSMYECKKSDQYDTADVPTYEEVTPYRRQTNEKYRLVVLVGPVG-VGLNELKRKLLISD 392
Query: 675 QFEIAETVSRTD-------------------------SPSKIIK------------LDTV 697
TV T +K I+ +D+V
Sbjct: 393 TQHYGVTVPHTTRARRSQESDGVEYIFISKHLFETDVQNNKFIEYGEYKNNYYGTSIDSV 452
Query: 698 RVIAEKDKHALLDVTPSAIERLNYVQYYPIVVFFIPESRPALKALRQ------------W 745
R + K+K LLDV P ++ L +++ P V+F P S L+ R+
Sbjct: 453 RSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERLRETRKNAKIISSRDDQGA 512
Query: 746 LAPASRRSTRRLYAQAQKLRKHSSHLFTATIPLNGTSDTWYQELKAIIREQQTRPIW 802
P + + + AQ + HLF I +N + ELK + +T W
Sbjct: 513 AKPFTEEDFQEMIKSAQIMESQYGHLFDKII-INDDLTVAFNELKTTFDKLETETHW 568
Score = 33.5 bits (75), Expect = 0.97
Identities = 28/92 (30%), Positives = 47/92 (51%), Gaps = 9/92 (9%)
Query: 8 PIFPAPLDQVADMEELTIWEQHTATLSKDPRRGFGIAISGGRDRPGGSMVVSDVVPGGPA 67
P+ P P+ + D EE ++ L K+ R G I +D G+++V+ ++ GG A
Sbjct: 121 PVLP-PMPEDIDDEEDSV---KIIRLVKN-REPLGATIK--KDEQTGAIIVARIMRGGAA 173
Query: 68 E--GRLQTGDHIVMVNGVSMENATSAFAIQIL 97
+ G + GD + VNG+ +E+ IQIL
Sbjct: 174 DRSGLIHVGDELREVNGIPVEDKRPEEIIQIL 205
>gi|218505835 membrane-associated guanylate kinase-related 3 isoform
1 [Homo sapiens]
Length = 1481
Score = 65.1 bits (157), Expect = 3e-10
Identities = 78/338 (23%), Positives = 133/338 (39%), Gaps = 60/338 (17%)
Query: 27 EQHTATLSKDPRRGFGIAISGGRDRPGGSMV---VSDVVPGGPAE--GRLQTGDHIVMVN 81
E + L + GFG I +++P ++ + V+ G PA+ G+L+ GDHI VN
Sbjct: 848 EPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVN 907
Query: 82 GVSMENATSAFAIQILKTCTKMANITVKRPRRIHLP--ATKASPSSP-------GRQDSD 132
G S+ + +Q++K +TV H P T ++ SP G+ ++
Sbjct: 908 GQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQAN 967
Query: 133 EDDGPQRVEEVDQGRGYDGDSSSGSGRSWDERSRRPRPGRRGRAGSHGRRSPGGGSEANG 192
G + E + G+ D S+ SW + +P
Sbjct: 968 HIPGDRSALEGEIGK----DVSTSYRHSWSDHKHLAQP---------------------D 1002
Query: 193 LALVSGFKRLPRQDVQMKPVKSVLVKRRDSEEFGVKL------GSQIFIKHITDSGLAAR 246
A++S Q++ PV+ R FG L +FI + + G A +
Sbjct: 1003 TAVISVVGSRHNQNLGCYPVE----LERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIK 1058
Query: 247 HRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRDRGQFLVNIPPAVSDSD 306
+ GD I++ING +Q ++ LI+ K+ LL+ G + P D D
Sbjct: 1059 DGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLLRPGTG-----LIPDHGDWD 1113
Query: 307 -SSPLEEGVTMADEMSSPPADISDLASELSQAPPSHIP 343
++P V ++ PP+ S AS + SH+P
Sbjct: 1114 INNPSSSNVIYDEQSPLPPS--SHFASIFEE---SHVP 1146
Score = 51.2 bits (121), Expect = 4e-06
Identities = 74/319 (23%), Positives = 130/319 (40%), Gaps = 60/319 (18%)
Query: 179 HGRRSPGGGSEANGLALVSGFKRLPRQDVQMKPVKS----VLVKRRDSEEFG-VKLGSQI 233
+G + P S ++ +G RL R +V +P V+++R+++E FG V L S+
Sbjct: 812 YGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKN 871
Query: 234 F---------IKHITDSGLAARHRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLS 284
I + + A R L+ GD I +NG S LS ++ +LI+ + ++
Sbjct: 872 KPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVT 931
Query: 285 LLVLRDRGQFLVNIPPAVSDSDSSPLEEGVTMADEMSSPPADISDLASELSQAPPSHIPP 344
L V+ + P + + SP + M Q+ +HIP
Sbjct: 932 LTVIAEEEHH--GPPSGTNSARQSPALQHRPMG------------------QSQANHIP- 970
Query: 345 PPRHAQRSPEASQTDSPVESPRLRRESSVDSRTISEPDEQRSELPRESSYDIYRVPSSQS 404
RS + V + R S D + +++PD + V S+
Sbjct: 971 ----GDRSALEGEIGKDVSTSY--RHSWSDHKHLAQPDTA-----------VISVVGSRH 1013
Query: 405 MEDRGYSPDTRVVRFLKG-KSIGLRLAGGND--VGIFVSGVQAGSPADGQG-IQEGDQIL 460
++ G P V +G + G L GG + +G+F+ + PA G I GDQI+
Sbjct: 1014 NQNLGCYP----VELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIV 1069
Query: 461 QVNDVPFQNLTREEAVQFL 479
++N P Q +T A++ +
Sbjct: 1070 EINGEPTQGITHTRAIELI 1088
Score = 43.5 bits (101), Expect = 0.001
Identities = 97/471 (20%), Positives = 177/471 (37%), Gaps = 85/471 (18%)
Query: 35 KDPRRGFGIAISGGRDRPGGSMVVSDVVPGGPA--EGRLQTGDHIVMVNGVSMENATSAF 92
K GFG I GG DRP + V +V+ GPA +G++ GD IV +NG + T A
Sbjct: 414 KKSTMGFGFTIIGG-DRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHAD 472
Query: 93 AIQILKTCTKMANITVKRPRRIHLPATKASPSSPGRQDSDEDDGPQRVEEVDQGRGYDGD 152
+Q+ + + + R LP D+ + P V+ V +G
Sbjct: 473 VVQMFQLVPVNQYVNLTLCRGYPLP--------------DDSEDPV-VDIVAATPVINGQ 517
Query: 153 SSSGSGRSWDERSRRPRPGRRGRAGSHGRRSPGGGSEANGLALVSGFKRLPRQDVQMKPV 212
S + + + +P + G G G G A Q + V
Sbjct: 518 SLTKGETCMNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELV 577
Query: 213 KSVLVKRRDSEEFGV---KLGSQIFIKHITDSGLAARHRGLQEGDLILQINGVSSQNLSL 269
L+K F + G + +K I DS +GLQ+GD+I +I + QNL+
Sbjct: 578 TIPLIKGPKGFGFAIADSPTGQK--VKMILDSQWC---QGLQKGDIIKEIYHQNVQNLTH 632
Query: 270 NDTRRLIEKSE--GKLSLLVLRDRGQFLVNIPPAVSDSDSSPLEEGVTMADEMSSPPADI 327
++++ + LL+LR PP SP T +M + +
Sbjct: 633 LQVVEVLKQFPVGADVPLLILRGG-------PP-------SP-----TKTAKMKTDKKEN 673
Query: 328 SDLASELSQAPPSHIPPPPRHAQRSPEASQTDSPVESPRLRRESSVDSRTISEPDEQRSE 387
+ +++ P +P P P ++ SP P E + S+T+ E +
Sbjct: 674 AGSLEAINEPIPQPMPFP-------PSIIRSGSPKLDP---SEVYLKSKTLYE-----DK 718
Query: 388 LPRESSYDIYRVPSSQSMEDRGYSPDTRVVRFLKGKSIGLRLAGGN--DVGIFVSGVQAG 445
P D++ ++ G+ G R+ GG+ D I++ +
Sbjct: 719 PPNTKDLDVF-----LRKQESGF---------------GFRVLGGDGPDQSIYIGAIIPL 758
Query: 446 SPADGQG-IQEGDQILQVNDVPFQNLTREEAVQFLLGLPPGEEMELVTQRK 495
A+ G ++ D+++ ++ +P + + ++ + + + L +RK
Sbjct: 759 GAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRK 809
>gi|13129124 caspase recruitment domain protein 14 isoform 1 [Homo
sapiens]
Length = 1004
Score = 64.7 bits (156), Expect = 4e-10
Identities = 106/428 (24%), Positives = 168/428 (39%), Gaps = 58/428 (13%)
Query: 427 LRLAGGNDVGIFVSGVQAGSPADGQGIQEGDQILQVN--------DVPFQNLTREEAVQF 478
+ + GGN GIF+ V GS AD ++ G QI+ V+ ++ T EEAV
Sbjct: 583 ISVIGGNLTGIFIHRVTPGSAADQMALRPGTQIVMVDYEASEPLFKAVLEDTTLEEAVGL 642
Query: 479 LLG------LPPGEEMELVTQRKQDIFWKMVQSRVGDSFYIRTHFELEPSPPSGLGFTRG 532
L L + + QD+ K+ S GDSFYIR + +E L
Sbjct: 643 LRRVDGFCCLSVKVNTDGYKRLLQDLEAKVATS--GDSFYIRVNLAMEGRAKGELQVHCN 700
Query: 533 DVFHVLDTLHPGPGQSHARGGHWLAVRMGRDLREQERGIIPNQSRA-EQLASL--EAAQR 589
+V HV DT+ G G HA + ++ G IPN SRA +QL +L + Q+
Sbjct: 701 EVLHVTDTMFQGCGCWHAHRVNSYTMK-----DTAAHGTIPNYSRAQQQLIALIQDMTQQ 755
Query: 590 AVGVGPGSSAGSNARAEFWRLRGLRRGAKKTT-QRSREDLSALTRQG---------RYPP 639
SS G + + + + R + D S + P
Sbjct: 756 CTVTRKPSSGGPQKLVRIVSMDKAKASPLRLSFDRGQLDPSRMEGSSTCFWAESCLTLVP 815
Query: 640 YERVVLREASFKRPVVIL-GPVADIAMQKL---------TAEMPDQFEIAETVSRTDSPS 689
Y V + RPV+++ V I +KL AE Q E R D
Sbjct: 816 YTLVWPHRPARPRPVLLVPRAVGKILSEKLCLLQGFKKCLAEYLSQEEYEAWSQRGDIIQ 875
Query: 690 K--------IIKLDTVRVIAEKDKHALLDVTPSAIERLNYVQYYPIVVFFIPESRPALKA 741
+ + V + EK+ HALLDV ++ L+ + +PIV+ + A K
Sbjct: 876 EGEVSGGRCWVTRHAVESLMEKNTHALLDVQLDSVCTLHRMDIFPIVIHVSVNEKMA-KK 934
Query: 742 LRQWLAPASRRSTRRLYAQAQKL--RKHSSHLFTATIPLNGTSDT--WYQELKAIIREQQ 797
L++ L + L A Q+ + L+++ P +G SD ++ I ++Q
Sbjct: 935 LKKGLQRLGTSEEQLLEAARQEEGDLDRAPCLYSSLAP-DGWSDLDGLLSCVRQAIADEQ 993
Query: 798 TRPIWTAE 805
+ +WT +
Sbjct: 994 KKVVWTEQ 1001
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 63.9 bits (154), Expect = 7e-10
Identities = 107/479 (22%), Positives = 195/479 (40%), Gaps = 86/479 (17%)
Query: 42 GIAISGGRDRPGGSMVVSDVVPGGPA--EGRLQTGDHIVMVNGVSMENATSAFAIQILKT 99
G+ +S +D G M+V ++ GG +GR+ GD I+ +N S + T+A A +L+
Sbjct: 1019 GMTVSANKD--GLGMIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQARAMLRR 1076
Query: 100 CTKMA-NITVKRPRRIHLPATKASPSSPGRQDSDEDDGPQRVEEVDQGRGYDGDSSSGSG 158
+ + +I + HL K S G+Q RV +D Y +G
Sbjct: 1077 HSLIGPDIKITYVPAEHLEEFKISL---GQQSG-------RVMALDIFSSY-------TG 1119
Query: 159 RSWDERSRRPRPGRRGRAGSHGRRSPGGGSEANGLALVSGFKRLPRQDVQMKPVKSVLVK 218
R E R G SE A S + + R ++ +P KS+ +
Sbjct: 1120 RDIPELPER-------------EEGEGEESELQNTAY-SNWNQPRRVELWREPSKSLGIS 1165
Query: 219 RRDSEEFGVKLGSQ-----IFIKHITDSGLAARHRGLQEGDLILQINGVSSQNLSLNDTR 273
G +L + IFIKH+ + A ++ L+ GD I++++G+ ++ S
Sbjct: 1166 IVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAV 1225
Query: 274 RLIEKSEGKLSLLVL----RDR----GQFLVNIPPAVSDSDSSPLEEGVTMADEMSSPPA 325
I K+ + +V R R L N+ P + S ++P + + + + +
Sbjct: 1226 EAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAP--- 1282
Query: 326 DISDLASELSQAPPSHIPPPPRHAQRSPEASQTDSPVESPRLRRESSVDSRTISEPDEQR 385
S SE +AP +PPPP A + T S +S S+ + + D
Sbjct: 1283 --SQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQS---------SASKISQDVDKED--- 1328
Query: 386 SELPRESSYDIYRVPSSQSMEDR--GYSPDTRVVRFLKGKS-IGLRLAGGND---VGIFV 439
E Y S +++ +R + + ++ KG S +GL LAG D + +F+
Sbjct: 1329 -----EFGY------SWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRMSVFI 1377
Query: 440 SGVQAGSPADGQG-IQEGDQILQVNDVPFQNLTREEAVQFLLGLPPGEEMELVTQRKQD 497
G+ A G +Q D++L++N + + A + P +++++ R +D
Sbjct: 1378 VGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAP--SKVKIIFIRNKD 1434
Score = 60.8 bits (146), Expect = 6e-09
Identities = 76/329 (23%), Positives = 133/329 (40%), Gaps = 38/329 (11%)
Query: 30 TATLSKDPRRGFGIAISGGRDRPGGSMVVSDVVPGGPA--EGRLQTGDHIVMVNGVSMEN 87
T +SK R G G++I GG D G++++ +V G A +GRL GD I+ VNG+ +
Sbjct: 1629 TIEISKG-RTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRK 1687
Query: 88 ATSAFAIQILKTCTKMANITVKR------PRRIHLPATKASPSSPGRQ-----DSDEDDG 136
AT AI +L+ + +T+ R + T PG+ +D
Sbjct: 1688 ATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDT 1747
Query: 137 PQRVEEVDQGRGYDGDSSSGSG------RSWDERSRRPRPGRRGRAGSHGRRS----PGG 186
V ++ +G D D G D R+ S G S P
Sbjct: 1748 GVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSEGSLSSFTFPLS 1807
Query: 187 GSEANGLALVSGFKRLPRQDVQMKPVKSVLVKRRDSEEFGVKLGS---------QIFIKH 237
GS + S K ++Q +++V +K+ ++ G+ + IFI
Sbjct: 1808 GSSTSESLESSSKKNALASEIQ--GLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAM 1865
Query: 238 ITDSGLAARHRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRDRGQFLV- 296
+ +G+AA+ + L+ GD I+ I G S++ ++ L++ + G + + V+ +V
Sbjct: 1866 MHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVT 1925
Query: 297 --NIPPAVSDSDSSPLEEGVTMADEMSSP 323
PA S + L D++ P
Sbjct: 1926 GHQQEPASSSLSFTGLTSSSIFQDDLGPP 1954
Score = 56.6 bits (135), Expect = 1e-07
Identities = 107/477 (22%), Positives = 187/477 (39%), Gaps = 64/477 (13%)
Query: 33 LSKDPRRGFGIAISGGRDRPGGSMVVSDVVPGGPA-EGRLQTGDHIVMVNGVSMENATSA 91
L KD + G GIAIS D G ++ S G A +GRL+ GD I+ V+ +
Sbjct: 1486 LPKD-QGGLGIAISE-EDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVD----DEIVVG 1539
Query: 92 FAIQILKTCTKMANITVKRPRRIHLPATKASPSSPGRQDSDEDDGPQRVEEVDQGRGYDG 151
+ I+ + K A +TVK P ++A PS+ G ++ + Q + V Q +
Sbjct: 1540 YPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSL-MVPQSGSPEP 1598
Query: 152 DSSSGSGRSWDERSRRPRPGRRG-RAGSHGRRSPGGGSEANGLALVSGFKRLPRQDVQMK 210
+S + RS P G G GL++V G L
Sbjct: 1599 ESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTL-------- 1650
Query: 211 PVKSVLVKRRDSEEFGVKLGSQIFIKHITDSGLAARHRGLQEGDLILQINGVSSQNLSLN 270
LG+ I I + + G A + L GD IL++NG+ + + +
Sbjct: 1651 ------------------LGA-IIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHD 1691
Query: 271 DTRRLIEKSEGKLSLLVLRDRGQFLVNIPPAVSDSDSSPLEE------GVTMADEMSSPP 324
+ ++ ++ ++ L + RD + V D+ + L++ G+++ + +
Sbjct: 1692 EAINVLRQTPQRVRLTLYRDEAPYK---EEEVCDTLTIELQKKPGKGLGLSIVGKRNDTG 1748
Query: 325 ADISDLASELSQAPPSHIPPPPRHAQRSPE--ASQTDSPVESPRLRRESSVDSRTISEPD 382
+SD+ + + + E + T V + E S+ S T
Sbjct: 1749 VFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSEGSLSSFTFPLSG 1808
Query: 383 EQRSELPRESSYDIYRVPSSQSMEDRGYSPDTRVVRFLKG--KSIGLRLAGG-----NDV 435
SE SS ++ + E +G R V KG S+G+ +AGG DV
Sbjct: 1809 SSTSESLESSS-----KKNALASEIQG----LRTVEMKKGPTDSLGISIAGGVGSPLGDV 1859
Query: 436 GIFVSGVQ-AGSPADGQGIQEGDQILQVNDVPFQNLTREEAVQFLLGLPPGEEMELV 491
IF++ + G A Q ++ GD+I+ + + +T +AV L EM++V
Sbjct: 1860 PIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVV 1916
Score = 56.2 bits (134), Expect = 1e-07
Identities = 34/83 (40%), Positives = 47/83 (56%), Gaps = 4/83 (4%)
Query: 18 ADMEELTIWEQHTATLSKDPRRGFGIAISGGRDRPGGSMVVSDVVPGG--PAEGRLQTGD 75
A +E + + T L K P +G G++I G R+ G + VSD+V GG A+GRL GD
Sbjct: 1713 APYKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDTG--VFVSDIVKGGIADADGRLMQGD 1770
Query: 76 HIVMVNGVSMENATSAFAIQILK 98
I+MVNG + NAT +LK
Sbjct: 1771 QILMVNGEDVRNATQEAVAALLK 1793
Score = 53.9 bits (128), Expect = 7e-07
Identities = 68/311 (21%), Positives = 116/311 (37%), Gaps = 46/311 (14%)
Query: 206 DVQMKPVK----SVLVKRRDSEEFGVKLGSQIFIKHITDSGLAARHRGLQEGDLILQING 261
++Q KP K S++ KR D+ +F+ I G+A L +GD IL +NG
Sbjct: 1727 ELQKKPGKGLGLSIVGKRNDTG---------VFVSDIVKGGIADADGRLMQGDQILMVNG 1777
Query: 262 VSSQNLSLNDTRRLIEKSEGKLSLLVLRDRGQFLVNIPPAVSDSDSSPLEEGVTMADEMS 321
+N + L++ SEG LS G + S ++ E EM
Sbjct: 1778 EDVRNATQEAVAALLKVSEGSLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMK 1837
Query: 322 SPPAD-------------ISDLASELSQAPPSHIPPPPRHAQ---------RSPEASQTD 359
P D + D+ ++ P+ + + + + T
Sbjct: 1838 KGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTH 1897
Query: 360 SPVESPRLRRESSVDSRTISEPDEQ----RSELPRESSYDIYRVPSSQSMEDRGYSPDTR 415
+ + S++ + ++ D + P SS + SS +D P +
Sbjct: 1898 TQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCK 1957
Query: 416 VVRFLKGKS-IGLRLAGG-----NDVGIFVSGVQAGSPADGQG-IQEGDQILQVNDVPFQ 468
+ +G +G + GG D+ I+V V A A G ++ GDQI+ VN +
Sbjct: 1958 SITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLE 2017
Query: 469 NLTREEAVQFL 479
+T EEAV L
Sbjct: 2018 GVTHEEAVAIL 2028
Score = 50.1 bits (118), Expect = 1e-05
Identities = 93/460 (20%), Positives = 175/460 (38%), Gaps = 80/460 (17%)
Query: 39 RGFGIAISG----GRDRPGGSMVVSDVVPGGPA-EGRLQTGDHIVMVNGVSMENATSAFA 93
+G GI I+G + P G V S +GR+Q GD I+ V+G +++ T+ A
Sbjct: 385 QGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQA 444
Query: 94 IQILKTCTKMANITVKRPRRIHLPATKASPSSPGRQD--SDEDDGPQRVEEVDQGRGYDG 151
+++L+ + +T+ R K R+D D D P + + D
Sbjct: 445 VEVLRHTGQTVLLTLMRR------GMKQEAELMSREDVTKDADLSPVNASIIKENYEKDE 498
Query: 152 DSSSGSGRSWDERSRRPRPGRR-GRAGSHGRRSPGGGSEANGLALVSGFKRLPRQDVQMK 210
D S + R+ P G ++ AL++ ++R+ + +
Sbjct: 499 DFLSST------RNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRI--MGINYE 550
Query: 211 PVKSVLVKRRDSEEFGVKLGSQI---FIKHITDSGLAARHRGLQEGDLILQINGVSSQNL 267
V + + K ++ G+ L + + FI+ + G L GD +L++NG++
Sbjct: 551 IVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGE 610
Query: 268 SLNDTRRLIEKSEGKLSLLVLRDRGQFLVNIPPAV-SDSDSSPLEEGVTMADEMSSPPAD 326
+ D ++++ +++++ R +PP S+ DS L + + P D
Sbjct: 611 NHQDVVNILKELPIEVTMVCCRR------TVPPTTQSELDSLDLCD----IELTEKPHVD 660
Query: 327 ISDLASELSQAPPSHIPPPPRHAQRSPEASQTDSPVESPRLRRESSVDSRTISEPDEQRS 386
+ + P +A Q+ V++P E+ + Q
Sbjct: 661 LGEFIGSSETEDP---------VLAMTDAGQSTEEVQAPLAMWEAGI----------QHI 701
Query: 387 ELPRESSYDIYRVPSSQSMEDRGYSPDTRVVRFLKGKSIGLRLAGGNDVGIFVSGVQAGS 446
EL + S + + Q D P + V I + + G
Sbjct: 702 ELEKGSKGLGFSILDYQDPID----PASTV--------------------IIIRSLVPGG 737
Query: 447 PADGQG-IQEGDQILQVNDVPFQNLTREEAVQFLLGLPPG 485
A+ G + GD+++ VNDV +N + EEAV+ L G P G
Sbjct: 738 IAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSG 777
Score = 44.3 bits (103), Expect = 5e-04
Identities = 30/71 (42%), Positives = 38/71 (53%), Gaps = 5/71 (7%)
Query: 32 TLSKDPRRGFGIAISGGRDRPGGSM--VVSDVVPGGPA--EGRLQTGDHIVMVNGVSMEN 87
TL + P G G +I GG P G + V V G A +GRL+ GD I+ VNG S+E
Sbjct: 1960 TLERGPD-GLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEG 2018
Query: 88 ATSAFAIQILK 98
T A+ ILK
Sbjct: 2019 VTHEEAVAILK 2029
Score = 43.5 bits (101), Expect = 0.001
Identities = 61/273 (22%), Positives = 106/273 (38%), Gaps = 79/273 (28%)
Query: 30 TATLSKDPRRGFGIAISGGRDRPGGSM--VVSDVVPGGPAEG--RLQTGDHIVMVNGVSM 85
T + K P GI+I+GG P G + ++ + P G A +L+ GD IV + G S
Sbjct: 1833 TVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTST 1892
Query: 86 ENATSAFAIQILKTCTKMANITVKRPRRIHL-------PATKASPSSPGRQDS---DEDD 135
E T A+ +LK + + V + + PA+ +S S G S +D
Sbjct: 1893 EGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPAS-SSLSFTGLTSSSIFQDDL 1951
Query: 136 GPQRVEEVDQGRGYDGDSSSGSGRSWDERSRRPRPGRRGRAGSHGRRSPGGGSEANGLAL 195
GP + + + RG DG G ++
Sbjct: 1952 GPPQCKSITLERGPDG---------------------------------------LGFSI 1972
Query: 196 VSGFKRLPRQDVQMKPVKSVLVKRRDSEEFGVKLGSQIFIKHITDSGLAARHRGLQEGDL 255
V G+ P D+ + VK+V K G A+ L+ GD
Sbjct: 1973 VGGYGS-PHGDLPIY-VKTVFAK-----------------------GAASEDGRLKRGDQ 2007
Query: 256 ILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVL 288
I+ +NG S + ++ + ++++++G ++L+VL
Sbjct: 2008 IIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVL 2040
Score = 43.1 bits (100), Expect = 0.001
Identities = 25/86 (29%), Positives = 42/86 (48%), Gaps = 6/86 (6%)
Query: 28 QHTATLSK-DPRRGFGIAISGGRDRPGGSMVVSDVVPGGPAE--GRLQTGDHIVMVNGVS 84
QH T+ + G G I GG+ ++V ++PGG A+ GRL +GDHI+ +
Sbjct: 253 QHMETIELVNDGSGLGFGIIGGK---ATGVIVKTILPGGVADQHGRLCSGDHILKIGDTD 309
Query: 85 MENATSAFAIQILKTCTKMANITVKR 110
+ +S Q+L+ C + + R
Sbjct: 310 LAGMSSEQVAQVLRQCGNRVKLMIAR 335
Score = 41.6 bits (96), Expect = 0.004
Identities = 78/356 (21%), Positives = 125/356 (35%), Gaps = 80/356 (22%)
Query: 33 LSKDPRRGFGIAISGGRDRPGGSM--VVSDVVPGGPA--EGRLQTGDHIVMVNGVSMENA 88
L K P G G ++ G R G + V ++ G A +GRL+ D I+ +NG +++
Sbjct: 140 LLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQT 199
Query: 89 -TSAFAIQILKTCTKMANITVKRPRRIHL--PATKASPSSPGRQDSDED----DGPQRVE 141
T AI IL+ + + R L P SPS+ + + + +E
Sbjct: 200 ITHQQAISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIE 259
Query: 142 EVDQGRGYDGDSSSGSGRSWDERSRRPRPGRRGRAGSHGRRSPG------GGSEANGL-- 193
V+ G G G ++ P G A HGR G G ++ G+
Sbjct: 260 LVNDGSGLGFGIIGGKATGVIVKTILP----GGVADQHGRLCSGDHILKIGDTDLAGMSS 315
Query: 194 ------------------------------ALVSGFKRLPRQDVQMKPVKSVLVKRRDSE 223
AL P +++ V + K +SE
Sbjct: 316 EQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELR-VDASTQKGEESE 374
Query: 224 EFGVKL---------------------GSQIFIKHITDSGLAARHRGLQEGDLILQINGV 262
F V+L S IF+K IT S +Q GD I+ ++G
Sbjct: 375 TFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGT 434
Query: 263 SSQNLSLNDTRRLIEKSEGKLSLLVLRDRGQ----FLVNIPPAVSDSDSSPLEEGV 314
+ Q + N + + G+ LL L RG L++ D+D SP+ +
Sbjct: 435 NLQGFT-NQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASI 489
Score = 41.6 bits (96), Expect = 0.004
Identities = 76/353 (21%), Positives = 129/353 (36%), Gaps = 65/353 (18%)
Query: 26 WEQ-HTATLSKDPRRGFGIAISGGRDRPGG--------SMVVSDVVPGGPA--EGRLQTG 74
W Q L ++P + GI+I GGR + + V+ PA G L+ G
Sbjct: 1146 WNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPG 1205
Query: 75 DHIVMVNGVSMENATSAFAIQILKTCTK----MANITVKRPRRIHLPA-----------T 119
D IV V+G+ + +A+ A++ ++ M + RPR+ LP+ +
Sbjct: 1206 DRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFS 1265
Query: 120 KASP----------SSPGRQDSDEDDG-----PQRVEEVDQGRGYDGDSSSGSGRSWDER 164
+P +P + +S+ + P G D SS S S D
Sbjct: 1266 STNPFADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDV- 1324
Query: 165 SRRPRPGRRGRAGSHGRRSPGG-GSEANGLALVSGFKRLPRQDVQMKPVKSVLVKRRDSE 223
+ G + + R G E + + L G L L +D
Sbjct: 1325 ---DKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLGLS----------LAGNKDRS 1371
Query: 224 EFGVKLGSQIFIKHITDSGLAARHRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKL 283
V FI I +G A + LQ D +L+ING S + +I+ + K+
Sbjct: 1372 RMSV------FIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKV 1425
Query: 284 SLLVLRDRGQFLVNIPPAVSDSDSSPL-EEGVTMADEMSSPPADISDLASELS 335
++ +R++ VN + PL + ++ + P SD A +LS
Sbjct: 1426 KIIFIRNKD--AVNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAVDLS 1476
Score = 40.4 bits (93), Expect = 0.008
Identities = 27/82 (32%), Positives = 46/82 (56%), Gaps = 6/82 (7%)
Query: 23 LTIWEQHTATLSKDP-RRGFGIAISGGRDR--PGGSMVV-SDVVPGGPAE--GRLQTGDH 76
L +WE + + +G G +I +D P ++++ +VPGG AE GRL GD
Sbjct: 691 LAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDR 750
Query: 77 IVMVNGVSMENATSAFAIQILK 98
++ VN V++EN++ A++ LK
Sbjct: 751 LMFVNDVNLENSSLEEAVEALK 772
Score = 39.3 bits (90), Expect = 0.018
Identities = 67/291 (23%), Positives = 118/291 (40%), Gaps = 69/291 (23%)
Query: 8 PIFPAPLDQVADMEE-----LTIWEQ-----------HTATLSKDPRRGFGIAISGGRDR 51
P+ A ++++ D ++ LT W++ H + S++ G GI++ +
Sbjct: 518 PLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENS--GLGISL----EA 571
Query: 52 PGGSMVVSDVVPGGPA--EGRLQTGDHIVMVNGVSMENATSAFAIQILKTCTKMANITVK 109
G + V+P GP G+L +GD ++ VNG+++ + ILK +T+
Sbjct: 572 TVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELP--IEVTMV 629
Query: 110 RPRRIHLPATKASPSSPGRQDSDEDDGPQRVEEVDQGRGYDGDSS--------SGSGRSW 161
RR P T++ S D + + P VD G + G S + +G+S
Sbjct: 630 CCRRTVPPTTQSELDSLDLCDIELTEKP----HVDLGE-FIGSSETEDPVLAMTDAGQST 684
Query: 162 DERSRRPRPGRRGRAG-SHGRRSPGGGSEANGLALVSGFKRLPRQDVQMKPVKSVLVKRR 220
+E P AG H G + GL GF L QD + P +V++
Sbjct: 685 EEVQ---APLAMWEAGIQHIELEKG----SKGL----GFSILDYQD-PIDPASTVII--- 729
Query: 221 DSEEFGVKLGSQIFIKHITDSGLAARHRGLQEGDLILQINGVSSQNLSLND 271
I+ + G+A + L GD ++ +N V+ +N SL +
Sbjct: 730 --------------IRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEE 766
Score = 38.9 bits (89), Expect = 0.023
Identities = 66/305 (21%), Positives = 116/305 (38%), Gaps = 74/305 (24%)
Query: 231 SQIFIKHITDSGLAARHRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRD 290
S + IK +T+ G+AA L+ GD IL ++ + L++ ++ + L + +
Sbjct: 1504 SGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAE 1563
Query: 291 RGQFLVNIPPAVSDSDSSPLEEGVTMADEMSSPPADISDLASELSQAPPSHIPPPPRHAQ 350
DS + P G ++ +S S+ P S P P
Sbjct: 1564 N-----------PDSQAVPSAAGAASGEKKNS---------SQSLMVPQSGSPEP----- 1598
Query: 351 RSPEASQTDSPVESPRLRRESSVDSRTISEPDEQRSELPRESSYDIYRVPSSQSMEDRGY 410
ES R SS + S+P ++ I +P ++
Sbjct: 1599 ------------ESIRNTSRSSTPAIFASDP----------ATCPI--IPGCET------ 1628
Query: 411 SPDTRVVRFLKGKS-IGLRLAGGNDV---GIFVSGV-QAGSPADGQGIQEGDQILQVNDV 465
+ KG++ +GL + GG+D I + V + G+ + GDQIL+VN +
Sbjct: 1629 -----TIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGI 1683
Query: 466 PFQNLTREEAVQFLLGLPPGEEMELVTQRKQDIFWKMVQSRVGDSFYIRTHFELEPSPPS 525
+ T +EA+ L P + + L R + + + V D+ I EL+ P
Sbjct: 1684 DLRKATHDEAINVLRQTP--QRVRLTLYRDEAPY---KEEEVCDTLTI----ELQKKPGK 1734
Query: 526 GLGFT 530
GLG +
Sbjct: 1735 GLGLS 1739
Score = 38.5 bits (88), Expect = 0.030
Identities = 22/57 (38%), Positives = 33/57 (57%), Gaps = 2/57 (3%)
Query: 425 IGLRLAGGNDVGIFVSGVQAGSPADGQG-IQEGDQILQVNDVPF-QNLTREEAVQFL 479
+GLR ++GIFV +Q GS A G ++E DQIL +N Q +T ++A+ L
Sbjct: 153 VGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAISIL 209
Score = 32.0 bits (71), Expect = 2.8
Identities = 19/92 (20%), Positives = 40/92 (43%), Gaps = 11/92 (11%)
Query: 233 IFIKHITDSGLAARHRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRDRG 292
+ +K I G+A +H L GD IL+I +S +++ + ++ L++ R
Sbjct: 279 VIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIAR--- 335
Query: 293 QFLVNIPPAVSDSDSSPLEEGVTMADEMSSPP 324
+ ++P G+T++ +S P
Sbjct: 336 --------GAIEERTAPTALGITLSSSPTSTP 359
>gi|155969695 membrane-associated guanylate kinase-related 3 isoform
2 [Homo sapiens]
Length = 1125
Score = 61.6 bits (148), Expect = 3e-09
Identities = 64/281 (22%), Positives = 111/281 (39%), Gaps = 49/281 (17%)
Query: 27 EQHTATLSKDPRRGFGIAISGGRDRPGGSMV---VSDVVPGGPAE--GRLQTGDHIVMVN 81
E + L + GFG I +++P ++ + V+ G PA+ G+L+ GDHI VN
Sbjct: 848 EPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVN 907
Query: 82 GVSMENATSAFAIQILKTCTKMANITVKRPRRIHLP--ATKASPSSP-------GRQDSD 132
G S+ + +Q++K +TV H P T ++ SP G+ ++
Sbjct: 908 GQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQAN 967
Query: 133 EDDGPQRVEEVDQGRGYDGDSSSGSGRSWDERSRRPRPGRRGRAGSHGRRSPGGGSEANG 192
G + E + G+ D S+ SW + +P
Sbjct: 968 HIPGDRSALEGEIGK----DVSTSYRHSWSDHKHLAQP---------------------D 1002
Query: 193 LALVSGFKRLPRQDVQMKPVKSVLVKRRDSEEFGVKL------GSQIFIKHITDSGLAAR 246
A++S Q++ PV+ R FG L +FI + + G A +
Sbjct: 1003 TAVISVVGSRHNQNLGCYPVE----LERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIK 1058
Query: 247 HRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLV 287
+ GD I++ING +Q ++ LI+ K+ LL+
Sbjct: 1059 DGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLL 1099
Score = 51.2 bits (121), Expect = 4e-06
Identities = 74/319 (23%), Positives = 130/319 (40%), Gaps = 60/319 (18%)
Query: 179 HGRRSPGGGSEANGLALVSGFKRLPRQDVQMKPVKS----VLVKRRDSEEFG-VKLGSQI 233
+G + P S ++ +G RL R +V +P V+++R+++E FG V L S+
Sbjct: 812 YGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKN 871
Query: 234 F---------IKHITDSGLAARHRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLS 284
I + + A R L+ GD I +NG S LS ++ +LI+ + ++
Sbjct: 872 KPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVT 931
Query: 285 LLVLRDRGQFLVNIPPAVSDSDSSPLEEGVTMADEMSSPPADISDLASELSQAPPSHIPP 344
L V+ + P + + SP + M Q+ +HIP
Sbjct: 932 LTVIAEEEHH--GPPSGTNSARQSPALQHRPMG------------------QSQANHIP- 970
Query: 345 PPRHAQRSPEASQTDSPVESPRLRRESSVDSRTISEPDEQRSELPRESSYDIYRVPSSQS 404
RS + V + R S D + +++PD + V S+
Sbjct: 971 ----GDRSALEGEIGKDVSTSY--RHSWSDHKHLAQPDTA-----------VISVVGSRH 1013
Query: 405 MEDRGYSPDTRVVRFLKG-KSIGLRLAGGND--VGIFVSGVQAGSPADGQG-IQEGDQIL 460
++ G P V +G + G L GG + +G+F+ + PA G I GDQI+
Sbjct: 1014 NQNLGCYP----VELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIV 1069
Query: 461 QVNDVPFQNLTREEAVQFL 479
++N P Q +T A++ +
Sbjct: 1070 EINGEPTQGITHTRAIELI 1088
Score = 43.5 bits (101), Expect = 0.001
Identities = 97/471 (20%), Positives = 177/471 (37%), Gaps = 85/471 (18%)
Query: 35 KDPRRGFGIAISGGRDRPGGSMVVSDVVPGGPA--EGRLQTGDHIVMVNGVSMENATSAF 92
K GFG I GG DRP + V +V+ GPA +G++ GD IV +NG + T A
Sbjct: 414 KKSTMGFGFTIIGG-DRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHAD 472
Query: 93 AIQILKTCTKMANITVKRPRRIHLPATKASPSSPGRQDSDEDDGPQRVEEVDQGRGYDGD 152
+Q+ + + + R LP D+ + P V+ V +G
Sbjct: 473 VVQMFQLVPVNQYVNLTLCRGYPLP--------------DDSEDPV-VDIVAATPVINGQ 517
Query: 153 SSSGSGRSWDERSRRPRPGRRGRAGSHGRRSPGGGSEANGLALVSGFKRLPRQDVQMKPV 212
S + + + +P + G G G G A Q + V
Sbjct: 518 SLTKGETCMNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELV 577
Query: 213 KSVLVKRRDSEEFGV---KLGSQIFIKHITDSGLAARHRGLQEGDLILQINGVSSQNLSL 269
L+K F + G + +K I DS +GLQ+GD+I +I + QNL+
Sbjct: 578 TIPLIKGPKGFGFAIADSPTGQK--VKMILDSQWC---QGLQKGDIIKEIYHQNVQNLTH 632
Query: 270 NDTRRLIEKSE--GKLSLLVLRDRGQFLVNIPPAVSDSDSSPLEEGVTMADEMSSPPADI 327
++++ + LL+LR PP SP T +M + +
Sbjct: 633 LQVVEVLKQFPVGADVPLLILRGG-------PP-------SP-----TKTAKMKTDKKEN 673
Query: 328 SDLASELSQAPPSHIPPPPRHAQRSPEASQTDSPVESPRLRRESSVDSRTISEPDEQRSE 387
+ +++ P +P P P ++ SP P E + S+T+ E +
Sbjct: 674 AGSLEAINEPIPQPMPFP-------PSIIRSGSPKLDP---SEVYLKSKTLYE-----DK 718
Query: 388 LPRESSYDIYRVPSSQSMEDRGYSPDTRVVRFLKGKSIGLRLAGGN--DVGIFVSGVQAG 445
P D++ ++ G+ G R+ GG+ D I++ +
Sbjct: 719 PPNTKDLDVF-----LRKQESGF---------------GFRVLGGDGPDQSIYIGAIIPL 758
Query: 446 SPADGQG-IQEGDQILQVNDVPFQNLTREEAVQFLLGLPPGEEMELVTQRK 495
A+ G ++ D+++ ++ +P + + ++ + + + L +RK
Sbjct: 759 GAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRK 809
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.132 0.385
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,854,883
Number of Sequences: 37866
Number of extensions: 2134611
Number of successful extensions: 11303
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 162
Number of HSP's successfully gapped in prelim test: 276
Number of HSP's that attempted gapping in prelim test: 9383
Number of HSP's gapped (non-prelim): 2093
length of query: 952
length of database: 18,247,518
effective HSP length: 112
effective length of query: 840
effective length of database: 14,006,526
effective search space: 11765481840
effective search space used: 11765481840
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.