Guide to the Human Genome
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Search of human proteins with 183979975

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|183979975 claudin 19 isoform b [Homo sapiens]
         (211 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|183979975 claudin 19 isoform b [Homo sapiens]                      427   e-120
gi|183979973 claudin 19 isoform a [Homo sapiens]                      424   e-119
gi|10863887 claudin 1 [Homo sapiens]                                  260   5e-70
gi|153792186 claudin 7 [Homo sapiens]                                 249   1e-66
gi|11141861 claudin 9 [Homo sapiens]                                  194   6e-50
gi|4502877 claudin 4 [Homo sapiens]                                   193   1e-49
gi|4502875 claudin 3 [Homo sapiens]                                   192   1e-49
gi|195947374 claudin 5 [Homo sapiens]                                 187   6e-48
gi|195947372 claudin 5 [Homo sapiens]                                 187   6e-48
gi|153792768 claudin 6 [Homo sapiens]                                 184   4e-47
gi|225703142 claudin 14 [Homo sapiens]                                184   6e-47
gi|21536294 claudin 14 [Homo sapiens]                                 184   6e-47
gi|225703138 claudin 14 [Homo sapiens]                                184   6e-47
gi|6912314 claudin 14 [Homo sapiens]                                  184   6e-47
gi|225703140 claudin 14 [Homo sapiens]                                184   6e-47
gi|9966781 claudin 2 [Homo sapiens]                                   168   4e-42
gi|6912316 claudin 17 [Homo sapiens]                                  164   4e-41
gi|40788011 claudin 8 [Homo sapiens]                                  161   4e-40
gi|7656981 claudin 15 [Homo sapiens]                                  161   4e-40
gi|5921465 claudin 10 isoform b [Homo sapiens]                        160   1e-39
gi|33598916 claudin 10 isoform a [Homo sapiens]                       152   2e-37
gi|50345279 claudin 18 isoform 2 [Homo sapiens]                       147   6e-36
gi|47716519 claudin 20 [Homo sapiens]                                 146   1e-35
gi|7705961 claudin 18 isoform 1 [Homo sapiens]                        144   5e-35
gi|231569235 claudin 10 isoform a_i1 [Homo sapiens]                   135   2e-32
gi|169166402 PREDICTED: claudin-24-like [Homo sapiens]                118   4e-27
gi|169167239 PREDICTED: claudin-24-like [Homo sapiens]                116   1e-26
gi|169166931 PREDICTED: claudin-24-like [Homo sapiens]                116   1e-26
gi|162417973 claudin 22 [Homo sapiens]                                114   5e-26
gi|10938016 claudin 11 [Homo sapiens]                                 105   4e-23

>gi|183979975 claudin 19 isoform b [Homo sapiens]
          Length = 211

 Score =  427 bits (1099), Expect = e-120
 Identities = 211/211 (100%), Positives = 211/211 (100%)

Query: 1   MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTG 60
           MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTG
Sbjct: 1   MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTG 60

Query: 61  QVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAI 120
           QVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAI
Sbjct: 61  QVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAI 120

Query: 121 AGGALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGS 180
           AGGALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGS
Sbjct: 121 AGGALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGS 180

Query: 181 FLCCTCPEPERPNSSPQPYRPGPSAAAREYV 211
           FLCCTCPEPERPNSSPQPYRPGPSAAAREYV
Sbjct: 181 FLCCTCPEPERPNSSPQPYRPGPSAAAREYV 211


>gi|183979973 claudin 19 isoform a [Homo sapiens]
          Length = 224

 Score =  424 bits (1089), Expect = e-119
 Identities = 210/211 (99%), Positives = 210/211 (99%)

Query: 1   MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTG 60
           MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTG
Sbjct: 1   MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTG 60

Query: 61  QVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAI 120
           QVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAI
Sbjct: 61  QVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAI 120

Query: 121 AGGALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGS 180
           AGGALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGS
Sbjct: 121 AGGALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGS 180

Query: 181 FLCCTCPEPERPNSSPQPYRPGPSAAAREYV 211
           FLCCTCPEPERPNSSPQPYRPGPSAAARE V
Sbjct: 181 FLCCTCPEPERPNSSPQPYRPGPSAAAREPV 211


>gi|10863887 claudin 1 [Homo sapiens]
          Length = 211

 Score =  260 bits (665), Expect = 5e-70
 Identities = 121/212 (57%), Positives = 159/212 (75%), Gaps = 2/212 (0%)

Query: 1   MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTG 60
           MAN+GLQLLG+ LA  GW+G I STALPQW+  SYAGD I+TA  +YEGLWMSC SQSTG
Sbjct: 1   MANAGLQLLGFILAFLGWIGAIVSTALPQWRIYSYAGDNIVTAQAMYEGLWMSCVSQSTG 60

Query: 61  QVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAI 120
           Q+QCK++DSLL L   +Q+ RALMVV +LLG +A+ ++ VGMKC +  + + + K R+A+
Sbjct: 61  QIQCKVFDSLLNLSSTLQATRALMVVGILLGVIAIFVATVGMKCMKCLEDDEVQKMRMAV 120

Query: 121 AGGALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGS 180
            GGA+F+LAGL  L A +WY   + QEF++P TPVNARYEFG ALF GWA+A L +LGG+
Sbjct: 121 IGGAIFLLAGLAILVATAWYGNRIVQEFYDPMTPVNARYEFGQALFTGWAAASLCLLGGA 180

Query: 181 FLCCTCPEPERPNSSPQPY-RPGPSAAAREYV 211
            LCC+CP       +P+PY +P PS + ++YV
Sbjct: 181 LLCCSCPRKTTSYPTPRPYPKPAPS-SGKDYV 211


>gi|153792186 claudin 7 [Homo sapiens]
          Length = 211

 Score =  249 bits (636), Expect = 1e-66
 Identities = 113/211 (53%), Positives = 153/211 (72%)

Query: 1   MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTG 60
           MANSGLQLLG+ +AL GWVG++A TA+PQW+ SSYAGD IITA  +Y+GLWM C +QSTG
Sbjct: 1   MANSGLQLLGFSMALLGWVGLVACTAIPQWQMSSYAGDNIITAQAMYKGLWMDCVTQSTG 60

Query: 61  QVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAI 120
            + CK+YDS+LAL   +Q+ RALMVV+++LGF+AM ++ +GMKCTR G  + + K R+A+
Sbjct: 61  MMSCKMYDSVLALSAALQATRALMVVSLVLGFLAMFVATMGMKCTRCGGDDKVKKARIAM 120

Query: 121 AGGALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGS 180
            GG +FI+AGL  L A SWY   +  +F+NP  P N +YEFGPA+F+GWA + L +LGG+
Sbjct: 121 GGGIIFIVAGLAALVACSWYGHQIVTDFYNPLIPTNIKYEFGPAIFIGWAGSALVILGGA 180

Query: 181 FLCCTCPEPERPNSSPQPYRPGPSAAAREYV 211
            L C+CP  E       P     S +++EYV
Sbjct: 181 LLSCSCPGNESKAGYRVPRSYPKSNSSKEYV 211


>gi|11141861 claudin 9 [Homo sapiens]
          Length = 217

 Score =  194 bits (492), Expect = 6e-50
 Identities = 98/218 (44%), Positives = 142/218 (65%), Gaps = 8/218 (3%)

Query: 1   MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTG 60
           MA++GL+LLG  LA+ GW+G + S ALP WK +++ G++I+ A  ++EGLWMSC  QSTG
Sbjct: 1   MASTGLELLGMTLAVLGWLGTLVSCALPLWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTG 60

Query: 61  QVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAI 120
           Q+QCK+YDSLLAL   +Q+ARAL V+A+LL  + +++++ G +CT   +    AK R+ +
Sbjct: 61  QMQCKVYDSLLALPQDLQAARALCVIALLLALLGLLVAITGAQCTTCVEDEG-AKARIVL 119

Query: 121 AGGALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGS 180
             G + +LAG+  L  V W A  + Q+F+NP      + E G +L++GWA+A L +LGG 
Sbjct: 120 TAGVILLLAGILVLIPVCWTAHAIIQDFYNPLVAEALKRELGASLYLGWAAAALLMLGGG 179

Query: 181 FLCCTCPEP--ERPNSSPQPYR-PGPSAAA----REYV 211
            LCCTCP P  ERP      Y  P  S A+    R+YV
Sbjct: 180 LLCCTCPPPQVERPRGPRLGYSIPSRSGASGLDKRDYV 217


>gi|4502877 claudin 4 [Homo sapiens]
          Length = 209

 Score =  193 bits (490), Expect = 1e-49
 Identities = 93/211 (44%), Positives = 137/211 (64%), Gaps = 2/211 (0%)

Query: 1   MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTG 60
           MA+ GLQ++G  LA+ GW+ ++   ALP W+ +++ G  I+T+  ++EGLWM+C  QSTG
Sbjct: 1   MASMGLQVMGIALAVLGWLAVMLCCALPMWRVTAFIGSNIVTSQTIWEGLWMNCVVQSTG 60

Query: 61  QVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAI 120
           Q+QCK+YDSLLAL   +Q+ARAL+++++++  + ++LSVVG KCT   +    AK +  I
Sbjct: 61  QMQCKVYDSLLALPQDLQAARALVIISIIVAALGVLLSVVGGKCTNCLEDES-AKAKTMI 119

Query: 121 AGGALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGS 180
             G +F+LAGL  +  VSW A  + Q+F+NP      + E G +L+VGWA++GL +LGG 
Sbjct: 120 VAGVVFLLAGLMVIVPVSWTAHNIIQDFYNPLVASGQKREMGASLYVGWAASGLLLLGGG 179

Query: 181 FLCCTCPEPERPNSSPQPYRPGPSAAAREYV 211
            LCC CP P         Y    SAAA  YV
Sbjct: 180 LLCCNCP-PRTDKPYSAKYSAARSAAASNYV 209


>gi|4502875 claudin 3 [Homo sapiens]
          Length = 220

 Score =  192 bits (489), Expect = 1e-49
 Identities = 94/207 (45%), Positives = 136/207 (65%), Gaps = 6/207 (2%)

Query: 5   GLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTGQVQC 64
           GL++ G  LA+ GW+G I   ALP W+ S++ G  IIT+  ++EGLWM+C  QSTGQ+QC
Sbjct: 4   GLEITGTALAVLGWLGTIVCCALPMWRVSAFIGSNIITSQNIWEGLWMNCVVQSTGQMQC 63

Query: 65  KLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAIAGGA 124
           K+YDSLLAL   +Q+ARAL+VVA+LL    +++++VG +CT     +  AK ++ I  G 
Sbjct: 64  KVYDSLLALPQDLQAARALIVVAILLAAFGLLVALVGAQCTNCVQDD-TAKAKITIVAGV 122

Query: 125 LFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGSFLCC 184
           LF+LA L TL  VSW A  + ++F+NP  P   + E G  L+VGWA+A L +LGG+ LCC
Sbjct: 123 LFLLAALLTLVPVSWSANTIIRDFYNPVVPEAQKREMGAGLYVGWAAAALQLLGGALLCC 182

Query: 185 TCPEPERPNSSPQ-----PYRPGPSAA 206
           +CP  E+  ++ +     P   GP A+
Sbjct: 183 SCPPREKKYTATKVVYSAPRSTGPGAS 209


>gi|195947374 claudin 5 [Homo sapiens]
          Length = 303

 Score =  187 bits (475), Expect = 6e-48
 Identities = 91/207 (43%), Positives = 131/207 (63%), Gaps = 7/207 (3%)

Query: 1   MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTG 60
           M ++ L++LG  L L GW G+I +  LP W+ +++    I+TA   ++GLWMSC  QSTG
Sbjct: 86  MGSAALEILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTG 145

Query: 61  QVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAI 120
            +QCK+YDS+LAL   +Q+ARAL V AVLL FVA+ +++ G +CT      P AK RVA+
Sbjct: 146 HMQCKVYDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTCVAPGP-AKARVAL 204

Query: 121 AGGALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGS 180
            GG L++  GL  L  + W+A +V +EF++PS PV+ +YE G AL++GWA+  L ++GG 
Sbjct: 205 TGGVLYLFCGLLALVPLCWFANIVVREFYDPSVPVSQKYELGAALYIGWAATALLMVGGC 264

Query: 181 FLCCTC------PEPERPNSSPQPYRP 201
            LCC        P+   P     P RP
Sbjct: 265 LLCCGAWVCTGRPDLSFPVKYSAPRRP 291


>gi|195947372 claudin 5 [Homo sapiens]
          Length = 303

 Score =  187 bits (475), Expect = 6e-48
 Identities = 91/207 (43%), Positives = 131/207 (63%), Gaps = 7/207 (3%)

Query: 1   MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTG 60
           M ++ L++LG  L L GW G+I +  LP W+ +++    I+TA   ++GLWMSC  QSTG
Sbjct: 86  MGSAALEILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTG 145

Query: 61  QVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAI 120
            +QCK+YDS+LAL   +Q+ARAL V AVLL FVA+ +++ G +CT      P AK RVA+
Sbjct: 146 HMQCKVYDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTCVAPGP-AKARVAL 204

Query: 121 AGGALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGS 180
            GG L++  GL  L  + W+A +V +EF++PS PV+ +YE G AL++GWA+  L ++GG 
Sbjct: 205 TGGVLYLFCGLLALVPLCWFANIVVREFYDPSVPVSQKYELGAALYIGWAATALLMVGGC 264

Query: 181 FLCCTC------PEPERPNSSPQPYRP 201
            LCC        P+   P     P RP
Sbjct: 265 LLCCGAWVCTGRPDLSFPVKYSAPRRP 291


>gi|153792768 claudin 6 [Homo sapiens]
          Length = 220

 Score =  184 bits (468), Expect = 4e-47
 Identities = 89/207 (42%), Positives = 133/207 (64%), Gaps = 1/207 (0%)

Query: 1   MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTG 60
           MA++G+Q+LG  L L GWV  + S ALP WK +++ G++I+ A  ++EGLWMSC  QSTG
Sbjct: 1   MASAGMQILGVVLTLLGWVNGLVSCALPMWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTG 60

Query: 61  QVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAI 120
           Q+QCK+YDSLLAL   +Q+ARAL V+A+L+    +++ + G KCT   +    +K R+ +
Sbjct: 61  QMQCKVYDSLLALPQDLQAARALCVIALLVALFGLLVYLAGAKCTTCVEEKD-SKARLVL 119

Query: 121 AGGALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGS 180
             G +F+++G+ TL  V W A  + ++F+NP      + E G +L++GWA++GL +LGG 
Sbjct: 120 TSGIVFVISGVLTLIPVCWTAHAIIRDFYNPLVAEAQKRELGASLYLGWAASGLLLLGGG 179

Query: 181 FLCCTCPEPERPNSSPQPYRPGPSAAA 207
            LCCTCP       S    R   SA A
Sbjct: 180 LLCCTCPSGGSQGPSHYMARYSTSAPA 206


>gi|225703142 claudin 14 [Homo sapiens]
          Length = 239

 Score =  184 bits (466), Expect = 6e-47
 Identities = 92/198 (46%), Positives = 130/198 (65%), Gaps = 3/198 (1%)

Query: 1   MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTG 60
           MA++ +QLLG+ L+  G VG + +T LP W+++++ G  I+TAV   +GLWM C   STG
Sbjct: 1   MASTAVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTG 60

Query: 61  QVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAI 120
             QC++Y SLLAL   +Q+ARALMV++ LL  +A   +V+GMKCTR     P AK   AI
Sbjct: 61  IYQCQIYRSLLALPQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTP-AKTTFAI 119

Query: 121 AGGALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGS 180
            GG LFILAGL  + AVSW    V Q F+NP  P   ++E G AL++G+ S+ L+++GG+
Sbjct: 120 LGGTLFILAGLLCMVAVSWTTNDVVQNFYNPLLPSGMKFEIGQALYLGFISSSLSLIGGT 179

Query: 181 FLCCTCPE--PERPNSSP 196
            LC +C +  P RP  +P
Sbjct: 180 LLCLSCQDEAPYRPYQAP 197


>gi|21536294 claudin 14 [Homo sapiens]
          Length = 239

 Score =  184 bits (466), Expect = 6e-47
 Identities = 92/198 (46%), Positives = 130/198 (65%), Gaps = 3/198 (1%)

Query: 1   MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTG 60
           MA++ +QLLG+ L+  G VG + +T LP W+++++ G  I+TAV   +GLWM C   STG
Sbjct: 1   MASTAVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTG 60

Query: 61  QVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAI 120
             QC++Y SLLAL   +Q+ARALMV++ LL  +A   +V+GMKCTR     P AK   AI
Sbjct: 61  IYQCQIYRSLLALPQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTP-AKTTFAI 119

Query: 121 AGGALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGS 180
            GG LFILAGL  + AVSW    V Q F+NP  P   ++E G AL++G+ S+ L+++GG+
Sbjct: 120 LGGTLFILAGLLCMVAVSWTTNDVVQNFYNPLLPSGMKFEIGQALYLGFISSSLSLIGGT 179

Query: 181 FLCCTCPE--PERPNSSP 196
            LC +C +  P RP  +P
Sbjct: 180 LLCLSCQDEAPYRPYQAP 197


>gi|225703138 claudin 14 [Homo sapiens]
          Length = 239

 Score =  184 bits (466), Expect = 6e-47
 Identities = 92/198 (46%), Positives = 130/198 (65%), Gaps = 3/198 (1%)

Query: 1   MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTG 60
           MA++ +QLLG+ L+  G VG + +T LP W+++++ G  I+TAV   +GLWM C   STG
Sbjct: 1   MASTAVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTG 60

Query: 61  QVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAI 120
             QC++Y SLLAL   +Q+ARALMV++ LL  +A   +V+GMKCTR     P AK   AI
Sbjct: 61  IYQCQIYRSLLALPQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTP-AKTTFAI 119

Query: 121 AGGALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGS 180
            GG LFILAGL  + AVSW    V Q F+NP  P   ++E G AL++G+ S+ L+++GG+
Sbjct: 120 LGGTLFILAGLLCMVAVSWTTNDVVQNFYNPLLPSGMKFEIGQALYLGFISSSLSLIGGT 179

Query: 181 FLCCTCPE--PERPNSSP 196
            LC +C +  P RP  +P
Sbjct: 180 LLCLSCQDEAPYRPYQAP 197


>gi|6912314 claudin 14 [Homo sapiens]
          Length = 239

 Score =  184 bits (466), Expect = 6e-47
 Identities = 92/198 (46%), Positives = 130/198 (65%), Gaps = 3/198 (1%)

Query: 1   MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTG 60
           MA++ +QLLG+ L+  G VG + +T LP W+++++ G  I+TAV   +GLWM C   STG
Sbjct: 1   MASTAVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTG 60

Query: 61  QVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAI 120
             QC++Y SLLAL   +Q+ARALMV++ LL  +A   +V+GMKCTR     P AK   AI
Sbjct: 61  IYQCQIYRSLLALPQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTP-AKTTFAI 119

Query: 121 AGGALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGS 180
            GG LFILAGL  + AVSW    V Q F+NP  P   ++E G AL++G+ S+ L+++GG+
Sbjct: 120 LGGTLFILAGLLCMVAVSWTTNDVVQNFYNPLLPSGMKFEIGQALYLGFISSSLSLIGGT 179

Query: 181 FLCCTCPE--PERPNSSP 196
            LC +C +  P RP  +P
Sbjct: 180 LLCLSCQDEAPYRPYQAP 197


>gi|225703140 claudin 14 [Homo sapiens]
          Length = 239

 Score =  184 bits (466), Expect = 6e-47
 Identities = 92/198 (46%), Positives = 130/198 (65%), Gaps = 3/198 (1%)

Query: 1   MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTG 60
           MA++ +QLLG+ L+  G VG + +T LP W+++++ G  I+TAV   +GLWM C   STG
Sbjct: 1   MASTAVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTG 60

Query: 61  QVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAI 120
             QC++Y SLLAL   +Q+ARALMV++ LL  +A   +V+GMKCTR     P AK   AI
Sbjct: 61  IYQCQIYRSLLALPQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTP-AKTTFAI 119

Query: 121 AGGALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGS 180
            GG LFILAGL  + AVSW    V Q F+NP  P   ++E G AL++G+ S+ L+++GG+
Sbjct: 120 LGGTLFILAGLLCMVAVSWTTNDVVQNFYNPLLPSGMKFEIGQALYLGFISSSLSLIGGT 179

Query: 181 FLCCTCPE--PERPNSSP 196
            LC +C +  P RP  +P
Sbjct: 180 LLCLSCQDEAPYRPYQAP 197


>gi|9966781 claudin 2 [Homo sapiens]
          Length = 230

 Score =  168 bits (425), Expect = 4e-42
 Identities = 89/215 (41%), Positives = 129/215 (60%), Gaps = 15/215 (6%)

Query: 1   MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTG 60
           MA+ GLQL+GY L L G +G + +  LP WK SSY G +I+TAVG  +GLWM CA+ STG
Sbjct: 1   MASLGLQLVGYILGLLGLLGTLVAMLLPSWKTSSYVGASIVTAVGFSKGLWMECATHSTG 60

Query: 61  QVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAI 120
             QC +Y +LL L   IQ+A+A+MV +  +  +A ++SVVGM+CT V      AK RVA+
Sbjct: 61  ITQCDIYSTLLGLPADIQAAQAMMVTSSAISSLACIISVVGMRCT-VFCQESRAKDRVAV 119

Query: 121 AGGALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGS 180
           AGG  FIL GL     V+W    + ++F++P  P + ++E G AL++G  S+  +++ G 
Sbjct: 120 AGGVFFILGGLLGFIPVAWNLHGILRDFYSPLVPDSMKFEIGEALYLGIISSLFSLIAGI 179

Query: 181 FLCCTC--------------PEPERPNSSPQPYRP 201
            LC +C               +P    SSP+P +P
Sbjct: 180 ILCFSCSSQRNRSNYYDAYQAQPLATRSSPRPGQP 214


>gi|6912316 claudin 17 [Homo sapiens]
          Length = 224

 Score =  164 bits (416), Expect = 4e-41
 Identities = 85/200 (42%), Positives = 120/200 (60%), Gaps = 2/200 (1%)

Query: 1   MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTG 60
           MA   LQ+ G  L   G VG +A+T LPQW+ S++ G  II    L+EGLWM+C  Q+  
Sbjct: 1   MAFYPLQIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARV 60

Query: 61  QVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAI 120
           ++QCK Y SLLAL   +++ARALM VAV L  +A+++ + GMK  +   SN  AK  +  
Sbjct: 61  RLQCKFYSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCTGSNERAKAYLLG 120

Query: 121 AGGALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGS 180
             G LFIL G+  L  VSW A ++ ++F+NP+  +  + E G ALF+GWASA +  +GG 
Sbjct: 121 TSGVLFILTGIFVLIPVSWTANIIIRDFYNPAIHIGQKRELGAALFLGWASAAVLFIGGG 180

Query: 181 FLC--CTCPEPERPNSSPQP 198
            LC  C C   ++    P P
Sbjct: 181 LLCGFCCCNRKKQGYRYPVP 200


>gi|40788011 claudin 8 [Homo sapiens]
          Length = 225

 Score =  161 bits (407), Expect = 4e-40
 Identities = 72/184 (39%), Positives = 114/184 (61%)

Query: 1   MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTG 60
           MA   L++ G FL   G VG +A T +PQW+ S++  + I+     +EGLWM+C  Q+  
Sbjct: 1   MATHALEIAGLFLGGVGMVGTVAVTVMPQWRVSAFIENNIVVFENFWEGLWMNCVRQANI 60

Query: 61  QVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAI 120
           ++QCK+YDSLLAL   +Q+AR LM  A ++ F+A +++++GMKCTR    N   K  + +
Sbjct: 61  RMQCKIYDSLLALSPDLQAARGLMCAASVMSFLAFMMAILGMKCTRCTGDNEKVKAHILL 120

Query: 121 AGGALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGS 180
             G +FI+ G+  L  VSW A  + ++F+N    V  + E G AL++GW +A + ++GG+
Sbjct: 121 TAGIIFIITGMVVLIPVSWVANAIIRDFYNSIVNVAQKRELGEALYLGWTTALVLIVGGA 180

Query: 181 FLCC 184
             CC
Sbjct: 181 LFCC 184


>gi|7656981 claudin 15 [Homo sapiens]
          Length = 228

 Score =  161 bits (407), Expect = 4e-40
 Identities = 79/198 (39%), Positives = 127/198 (64%), Gaps = 5/198 (2%)

Query: 6   LQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTGQVQCK 65
           ++  G+F+A  G + +  +     W+ S+  G+ +IT   ++E LW SCA+ S G   C 
Sbjct: 5   VETFGFFMATVGLLMLGVTLPNSYWRVSTVHGN-VITTNTIFENLWFSCATDSLGVYNCW 63

Query: 66  LYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAIAGGAL 125
            + S+LAL G+IQ+ RALM+ A+LLGF+ ++L + G++CT +G      K ++A   GAL
Sbjct: 64  EFPSMLALSGYIQACRALMITAILLGFLGLLLGIAGLRCTNIGGLELSRKAKLAATAGAL 123

Query: 126 FILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGSFLC-- 183
            ILAG+C + A+SWYA  +T++FF+P  P   +YE GPAL++GW+++ +++LGG  LC  
Sbjct: 124 HILAGICGMVAISWYAFNITRDFFDPLYP-GTKYELGPALYLGWSASLISILGGLCLCSA 182

Query: 184 CTCPEPERPNSSP-QPYR 200
           C C   E P +S  +PY+
Sbjct: 183 CCCGSDEDPAASARRPYQ 200


>gi|5921465 claudin 10 isoform b [Homo sapiens]
          Length = 228

 Score =  160 bits (404), Expect = 1e-39
 Identities = 78/183 (42%), Positives = 116/183 (63%), Gaps = 3/183 (1%)

Query: 1   MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTG 60
           MA++  +++ + +++ GWV + ++     WK S+  G  I TA   +  LW +C + STG
Sbjct: 1   MASTASEIIAFMVSISGWVLVSSTLPTDYWKVSTIDGTVITTAT-YWANLWKACVTDSTG 59

Query: 61  QVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAI 120
              CK + S+LALDG+IQ+ R LM+ AV LGF   + ++ GMKCT+VG S+  AK ++A 
Sbjct: 60  VSNCKDFPSMLALDGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDK-AKAKIAC 118

Query: 121 AGGALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGS 180
             G +FIL+GLC++T  S YA  +T EFF+P   V  +YE G ALF+GWA A L ++GG 
Sbjct: 119 LAGIVFILSGLCSMTGCSLYANKITTEFFDPLF-VEQKYELGAALFIGWAGASLCIIGGV 177

Query: 181 FLC 183
             C
Sbjct: 178 IFC 180


>gi|33598916 claudin 10 isoform a [Homo sapiens]
          Length = 226

 Score =  152 bits (384), Expect = 2e-37
 Identities = 74/180 (41%), Positives = 114/180 (63%), Gaps = 3/180 (1%)

Query: 4   SGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTGQVQ 63
           S  Q+      +GG+  ++A+T   +WK ++ A  ++ITA  +Y+GLWM+CA  + G   
Sbjct: 2   SRAQIWALVSGVGGFGALVAATTSNEWKVTTRAS-SVITATWVYQGLWMNCAGNALGSFH 60

Query: 64  CKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAIAGG 123
           C+ + ++  + G+IQ+ R LM+ AV LGF   + ++ GMKCT+VG S+  AK ++A   G
Sbjct: 61  CRPHFTIFKVAGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDK-AKAKIACLAG 119

Query: 124 ALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGSFLC 183
            +FIL+GLC++T  S YA  +T EFF+P   V  +YE G ALF+GWA A L ++GG   C
Sbjct: 120 IVFILSGLCSMTGCSLYANKITTEFFDPLF-VEQKYELGAALFIGWAGASLCIIGGVIFC 178


>gi|50345279 claudin 18 isoform 2 [Homo sapiens]
          Length = 261

 Score =  147 bits (371), Expect = 6e-36
 Identities = 77/220 (35%), Positives = 119/220 (54%), Gaps = 14/220 (6%)

Query: 1   MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTG 60
           MA +  Q LG+ ++L G  GIIA+T + QW       + + TAV  Y+GLW SC  +S+G
Sbjct: 1   MAVTACQGLGFVVSLIGIAGIIAATCMDQWSTQDLYNNPV-TAVFNYQGLWRSCVRESSG 59

Query: 61  QVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAI 120
             +C+ Y +LL L   +Q+ RALM+V ++LG + +++S+  +KC R+G     AK  + +
Sbjct: 60  FTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTL 119

Query: 121 AGGALFILAGLCTLTAVSWYATLVTQEFFNPST-----------PVNARYEFGPALFVGW 169
             G +FI++GLC +  VS +A ++   F+  +             V  RY FG ALFVGW
Sbjct: 120 TSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGW 179

Query: 170 ASAGLAVLGGSFLCCTCP--EPERPNSSPQPYRPGPSAAA 207
            + GL ++GG  +C  C    PE  N     Y     + A
Sbjct: 180 VAGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVA 219


>gi|47716519 claudin 20 [Homo sapiens]
          Length = 219

 Score =  146 bits (368), Expect = 1e-35
 Identities = 78/202 (38%), Positives = 113/202 (55%), Gaps = 5/202 (2%)

Query: 1   MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTG 60
           MA++GLQLL + LAL G  G++ +T LP WK +      IITA+    GLWM C   STG
Sbjct: 1   MASAGLQLLAFILALSGVSGVLTATLLPNWKVNVDVDSNIITAIVQLHGLWMDCTWYSTG 60

Query: 61  QVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAI 120
              C L  S+L+L  H+Q+ARA MV+A +L  + +  S VGMKCTR+G      K   + 
Sbjct: 61  MFSCALKHSILSLPIHVQAARATMVLACVLSALGICTSTVGMKCTRLGGDRE-TKSHASF 119

Query: 121 AGGALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGS 180
           AGG  F+ AG+ +L +  WY   +   F + + P + ++E G A+++G+ SA L  + G 
Sbjct: 120 AGGVCFMSAGISSLISTVWYTKEIIANFLDLTVPESNKHEPGGAIYIGFISAMLLFISGM 179

Query: 181 FLCCTC----PEPERPNSSPQP 198
             C +C    PE      + QP
Sbjct: 180 IFCTSCIKRNPEARLDPPTQQP 201


>gi|7705961 claudin 18 isoform 1 [Homo sapiens]
          Length = 261

 Score =  144 bits (363), Expect = 5e-35
 Identities = 75/221 (33%), Positives = 119/221 (53%), Gaps = 16/221 (7%)

Query: 1   MANSGLQLLGYFLALGGWVGIIASTALPQWK-QSSYAGDAIITAVGLYEGLWMSCASQST 59
           M+ +  Q++ + L++ G  G IA+T +  W  Q  Y  D  +T+V  YEGLW SC  QS+
Sbjct: 1   MSTTTCQVVAFLLSILGLAGCIAATGMDMWSTQDLY--DNPVTSVFQYEGLWRSCVRQSS 58

Query: 60  GQVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVA 119
           G  +C+ Y ++L L   +Q+ RALM+V ++LG + +++S+  +KC R+G     AK  + 
Sbjct: 59  GFTECRPYFTILGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMT 118

Query: 120 IAGGALFILAGLCTLTAVSWYATLVTQEFFNPST-----------PVNARYEFGPALFVG 168
           +  G +FI++GLC +  VS +A ++   F+  +             V  RY FG ALFVG
Sbjct: 119 LTSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVG 178

Query: 169 WASAGLAVLGGSFLCCTCP--EPERPNSSPQPYRPGPSAAA 207
           W + GL ++GG  +C  C    PE  N     Y     + A
Sbjct: 179 WVAGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVA 219


>gi|231569235 claudin 10 isoform a_i1 [Homo sapiens]
          Length = 207

 Score =  135 bits (341), Expect = 2e-32
 Identities = 72/180 (40%), Positives = 106/180 (58%), Gaps = 22/180 (12%)

Query: 4   SGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTGQVQ 63
           S  Q+      +GG+  ++A+T   +WK ++ A  ++ITA  +Y+GLWM+CA        
Sbjct: 2   SRAQIWALVSGVGGFGALVAATTSNEWKVTTRAS-SVITATWVYQGLWMNCA-------- 52

Query: 64  CKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAIAGG 123
                      G+IQ+ R LM+ AV LGF   + ++ GMKCT+VG S+  AK ++A   G
Sbjct: 53  -----------GYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDK-AKAKIACLAG 100

Query: 124 ALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGSFLC 183
            +FIL+GLC++T  S YA  +T EFF+P   V  +YE G ALF+GWA A L ++GG   C
Sbjct: 101 IVFILSGLCSMTGCSLYANKITTEFFDPLF-VEQKYELGAALFIGWAGASLCIIGGVIFC 159


>gi|169166402 PREDICTED: claudin-24-like [Homo sapiens]
          Length = 220

 Score =  118 bits (295), Expect = 4e-27
 Identities = 68/190 (35%), Positives = 102/190 (53%), Gaps = 4/190 (2%)

Query: 4   SGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTGQVQ 63
           + +Q +G  L+L GW+  I +T LP WK  +   + +        GLW +C  Q    +Q
Sbjct: 7   TAMQSVGLLLSLLGWILSIITTYLPHWKNLNLDLNEMENWT---MGLWQTCVIQEEVGMQ 63

Query: 64  CKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAIAGG 123
           CK +DS LAL   ++ +R LM ++  LGF+ +++S  G+ C R+G+S    K R+ I GG
Sbjct: 64  CKDFDSFLALPAELRVSRILMFLSNGLGFLGLLVSGFGLDCLRIGESQRDLKRRLLILGG 123

Query: 124 ALFILAGLCTLTAVSWYATLVTQEFFNPSTP-VNARYEFGPALFVGWASAGLAVLGGSFL 182
            L   +G+  L  VSW A    QEF++ + P    R+EFG ALF+GW +    +LGG  L
Sbjct: 124 ILSWASGITALVPVSWVAHKTVQEFWDENVPDFVPRWEFGEALFLGWFAGLSLLLGGCLL 183

Query: 183 CCTCPEPERP 192
            C       P
Sbjct: 184 NCAACSSHAP 193


>gi|169167239 PREDICTED: claudin-24-like [Homo sapiens]
          Length = 220

 Score =  116 bits (291), Expect = 1e-26
 Identities = 67/190 (35%), Positives = 101/190 (53%), Gaps = 4/190 (2%)

Query: 4   SGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTGQVQ 63
           + +Q +G  L+  GW+  I +T LP WK  +   + +        GLW +C  Q    +Q
Sbjct: 7   TAMQSVGLLLSFLGWILSIITTYLPHWKNLNLDLNEMENWT---MGLWQTCVIQEEVGMQ 63

Query: 64  CKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAIAGG 123
           CK +DS LAL   ++ +R LM ++  LGF+ +++S  G+ C R+G+S    K R+ I GG
Sbjct: 64  CKDFDSFLALPAELRVSRILMFLSNGLGFLGLLVSGFGLDCLRIGESQRDLKRRLLILGG 123

Query: 124 ALFILAGLCTLTAVSWYATLVTQEFFNPSTP-VNARYEFGPALFVGWASAGLAVLGGSFL 182
            L   +G+  L  VSW A    QEF++ + P    R+EFG ALF+GW +    +LGG  L
Sbjct: 124 ILSWASGITALVPVSWVAHKTVQEFWDENVPDFVPRWEFGEALFLGWFAGLSLLLGGCLL 183

Query: 183 CCTCPEPERP 192
            C       P
Sbjct: 184 NCAACSSHAP 193


>gi|169166931 PREDICTED: claudin-24-like [Homo sapiens]
          Length = 220

 Score =  116 bits (291), Expect = 1e-26
 Identities = 67/190 (35%), Positives = 101/190 (53%), Gaps = 4/190 (2%)

Query: 4   SGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTGQVQ 63
           + +Q +G  L+  GW+  I +T LP WK  +   + +        GLW +C  Q    +Q
Sbjct: 7   TAMQSVGLLLSFLGWILSIITTYLPHWKNLNLDLNEMENWT---MGLWQTCVIQEEVGMQ 63

Query: 64  CKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAIAGG 123
           CK +DS LAL   ++ +R LM ++  LGF+ +++S  G+ C R+G+S    K R+ I GG
Sbjct: 64  CKDFDSFLALPAELRVSRILMFLSNGLGFLGLLVSGFGLDCLRIGESQRDLKRRLLILGG 123

Query: 124 ALFILAGLCTLTAVSWYATLVTQEFFNPSTP-VNARYEFGPALFVGWASAGLAVLGGSFL 182
            L   +G+  L  VSW A    QEF++ + P    R+EFG ALF+GW +    +LGG  L
Sbjct: 124 ILSWASGITALVPVSWVAHKTVQEFWDENVPDFVPRWEFGEALFLGWFAGLSLLLGGCLL 183

Query: 183 CCTCPEPERP 192
            C       P
Sbjct: 184 NCAACSSHAP 193


>gi|162417973 claudin 22 [Homo sapiens]
          Length = 220

 Score =  114 bits (286), Expect = 5e-26
 Identities = 69/190 (36%), Positives = 100/190 (52%), Gaps = 4/190 (2%)

Query: 7   QLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTGQVQCKL 66
           QL G  L+L GWV    +  LP WK  +   + +        GLW +C  Q    +QCK 
Sbjct: 10  QLAGVSLSLLGWVLSCLTNYLPHWKNLNLDLNEMENWT---MGLWQTCVIQEEVGMQCKD 66

Query: 67  YDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAIAGGALF 126
           +DS LAL   ++ +R LM ++  LGF+ +++S  G+ C R+G+S    K R+ I GG L 
Sbjct: 67  FDSFLALPAELRVSRILMFLSNGLGFLGLLVSGFGLDCLRIGESQRDLKRRLLILGGILS 126

Query: 127 ILAGLCTLTAVSWYATLVTQEFFNPSTP-VNARYEFGPALFVGWASAGLAVLGGSFLCCT 185
             +G+  L  VSW A    QEF++ + P    R+EFG ALF+GW +    +LGG  L C 
Sbjct: 127 WASGVTALVPVSWVAHKTVQEFWDENVPDFVPRWEFGEALFLGWFAGLSLLLGGCLLHCA 186

Query: 186 CPEPERPNSS 195
                 P +S
Sbjct: 187 ACSSHAPLAS 196


>gi|10938016 claudin 11 [Homo sapiens]
          Length = 207

 Score =  105 bits (261), Expect = 4e-23
 Identities = 68/209 (32%), Positives = 104/209 (49%), Gaps = 15/209 (7%)

Query: 1   MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYE----GLWMSCAS 56
           M  + LQ++G+  +  GW+G+I +T+   W  +   G  I T   L E    GLW  C  
Sbjct: 1   MVATCLQVVGFVTSFVGWIGVIVTTSTNDWVVT--CGYTIPTCRKLDELGSKGLWADCV- 57

Query: 57  QSTGQVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKG 116
            +TG   CK    +L L G++Q+ RALM+ A +LG  A++L +  + C R+G    +AK 
Sbjct: 58  MATGLYHCKPLVDILILPGYVQACRALMIAASVLGLPAILLLLTVLPCIRMGQEPGVAKY 117

Query: 117 RVAIAGGALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAV 176
           R A   G L IL  LC L A  W+     +E    +T V+    FG +L+ GW  A L +
Sbjct: 118 RRAQLAGVLLILLALCALVATIWFPVCAHRE----TTIVS----FGYSLYAGWIGAVLCL 169

Query: 177 LGGSFLCCTCPEPERPNSSPQPYRPGPSA 205
           +GG  + C   + +    +   Y  G S+
Sbjct: 170 VGGCVILCCAGDAQAFGENRFYYTAGSSS 198


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.136    0.428 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 8,363,073
Number of Sequences: 37866
Number of extensions: 367081
Number of successful extensions: 1577
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 51
Number of HSP's successfully gapped in prelim test: 24
Number of HSP's that attempted gapping in prelim test: 1476
Number of HSP's gapped (non-prelim): 78
length of query: 211
length of database: 18,247,518
effective HSP length: 98
effective length of query: 113
effective length of database: 14,536,650
effective search space: 1642641450
effective search space used: 1642641450
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 59 (27.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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