Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 17864094
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|17864094 feminization 1 homolog a [Homo sapiens]
(617 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|17864094 feminization 1 homolog a [Homo sapiens] 1235 0.0
gi|24308163 fem-1 homolog a [Homo sapiens] 743 0.0
gi|7657265 fem-1 homolog b [Homo sapiens] 426 e-119
gi|169218177 PREDICTED: similar to fem-1 homolog a, partial [Hom... 363 e-100
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 129 6e-30
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 115 9e-26
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 115 9e-26
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 115 9e-26
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 115 9e-26
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 115 9e-26
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 110 4e-24
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 110 4e-24
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 110 4e-24
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 110 4e-24
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 108 1e-23
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 108 1e-23
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 107 3e-23
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 107 3e-23
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 100 5e-21
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 100 5e-21
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled... 99 9e-21
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled... 99 9e-21
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 99 9e-21
gi|155969701 espin-like [Homo sapiens] 99 2e-20
gi|70995267 ankyrin repeat domain 29 [Homo sapiens] 96 1e-19
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled... 95 2e-19
gi|34304381 inversin isoform a [Homo sapiens] 95 2e-19
gi|34304379 inversin isoform b [Homo sapiens] 95 2e-19
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu... 94 4e-19
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 94 5e-19
>gi|17864094 feminization 1 homolog a [Homo sapiens]
Length = 617
Score = 1235 bits (3195), Expect = 0.0
Identities = 617/617 (100%), Positives = 617/617 (100%)
Query: 1 MDLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFL 60
MDLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFL
Sbjct: 1 MDLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFL 60
Query: 61 LEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPL 120
LEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPL
Sbjct: 61 LEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPL 120
Query: 121 RAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSV 180
RAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSV
Sbjct: 121 RAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSV 180
Query: 181 KGNTALHDCAESGSLDIMKMLLMYCAKMEKDGYGMTPLLSASVTGHTNIVDFLTHHAQTS 240
KGNTALHDCAESGSLDIMKMLLMYCAKMEKDGYGMTPLLSASVTGHTNIVDFLTHHAQTS
Sbjct: 181 KGNTALHDCAESGSLDIMKMLLMYCAKMEKDGYGMTPLLSASVTGHTNIVDFLTHHAQTS 240
Query: 241 KTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAK 300
KTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAK
Sbjct: 241 KTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAK 300
Query: 301 EVNSAEELEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINL 360
EVNSAEELEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINL
Sbjct: 301 EVNSAEELEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINL 360
Query: 361 WKYALDMQQSNLDPLSPMTASSLLSFAELFSFMLQDRAKGLLGTTVTFDDLMGILCKSVL 420
WKYALDMQQSNLDPLSPMTASSLLSFAELFSFMLQDRAKGLLGTTVTFDDLMGILCKSVL
Sbjct: 361 WKYALDMQQSNLDPLSPMTASSLLSFAELFSFMLQDRAKGLLGTTVTFDDLMGILCKSVL 420
Query: 421 EIERAIKQTQCPADPLQLNKALSIILHLICLLEKVPCTLEQDHFKKQTIYRFLKLHPRGK 480
EIERAIKQTQCPADPLQLNKALSIILHLICLLEKVPCTLEQDHFKKQTIYRFLKLHPRGK
Sbjct: 421 EIERAIKQTQCPADPLQLNKALSIILHLICLLEKVPCTLEQDHFKKQTIYRFLKLHPRGK 480
Query: 481 NNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNH 540
NNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNH
Sbjct: 481 NNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNH 540
Query: 541 PDIMNLLIKSGAHFDATNLHKQTASDLLDEKEIAKNLIQPINHTTLQCLAARVIVNHRIY 600
PDIMNLLIKSGAHFDATNLHKQTASDLLDEKEIAKNLIQPINHTTLQCLAARVIVNHRIY
Sbjct: 541 PDIMNLLIKSGAHFDATNLHKQTASDLLDEKEIAKNLIQPINHTTLQCLAARVIVNHRIY 600
Query: 601 YKGHIPEKLETFVSLHR 617
YKGHIPEKLETFVSLHR
Sbjct: 601 YKGHIPEKLETFVSLHR 617
>gi|24308163 fem-1 homolog a [Homo sapiens]
Length = 669
Score = 743 bits (1918), Expect = 0.0
Identities = 397/672 (59%), Positives = 479/672 (71%), Gaps = 59/672 (8%)
Query: 1 MDLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFL 60
MDL+TAV+NAARDGKL+LL KLL+ +S+EE+ L E G TPLL+AARYGHLD+VE+L
Sbjct: 1 MDLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYL 60
Query: 61 LEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPL 120
+++C AS+E GGSV+FDGETIEGAPPLWAASAAGHL VV+SLL GASVN TT TNSTPL
Sbjct: 61 VDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPL 120
Query: 121 RAACFDGHLEIVKYLV-EHKADLEVSNRHGHTCLMISCYKGHKE---------------- 163
RAACFDGHLE+V+YLV EH+ADLEV+NRHGHTCLMISCYKGH+E
Sbjct: 121 RAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRS 180
Query: 164 -----------------IAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCA 206
I Q LL A + R G T L + +G +I++ L+
Sbjct: 181 AKGNTALHDCAESGSLEILQLLLGCKARMERDGY-GMTPLLAASVTGHTNIVEYLIQEQP 239
Query: 207 KMEKDGYGMT---------------------PLLSASVTGHTNIVDFLTHHAQTSKTERI 245
E+ G P S+S N + + TS+ +
Sbjct: 240 GQEQVAGGEAQPGLPQEDPSTSQGCAQPQGAPCCSSSPEEPLNGESYESC-CPTSREAAV 298
Query: 246 NALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAKEVNSA 305
ALELLGAT+VDKKRDLLGALK+W++AM +R+ + KP P L++AYDY++EVN+
Sbjct: 299 EALELLGATYVDKKRDLLGALKHWRRAMELRHQGG-EYLPKPEPPQLVLAYDYSREVNTT 357
Query: 306 EELEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINLWKYAL 365
EELE LI DPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNF+RCI LWKYAL
Sbjct: 358 EELEALITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLWKYAL 417
Query: 366 DMQQSNLDPLSPMTASSLLSFAELFSFMLQDRA-KGLLGTTVTFDDLMGILCKSVLEIER 424
DMQQSNL+PLSPMTASS LSFAELFS++LQDRA KG LGT + F DLMG+L K V E+ER
Sbjct: 418 DMQQSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQIGFADLMGVLTKGVREVER 477
Query: 425 AIKQTQCPADPLQLNKALSIILHLICLLEKVPCTLEQDHFKKQTIYRFLKLHPRGKNNFS 484
A++ + P D Q KAL+IILHL+ LLEKV CT Q+H K QT+YR LK PRGKN F+
Sbjct: 478 ALQLPREPGDSAQFTKALAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKNGFT 537
Query: 485 PLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIM 544
PLH+AVDK+TT VGRYPV +FPSL V +L++CGAD + RD D+N+PLHIAA NN P IM
Sbjct: 538 PLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIM 597
Query: 545 NLLIKSGAHFDATNLHKQTASDLLDEKEIAKNLIQPINHTTLQCLAARVIVNHRIYYKGH 604
N LI++GAH DATN K+TA +LLDEK +A+ +QP N+ TLQCLAAR + ++I YKG
Sbjct: 598 NALIEAGAHMDATNAFKKTAYELLDEKLLARGTMQPFNYVTLQCLAARALDKNKIPYKGF 657
Query: 605 IPEKLETFVSLH 616
IPE LE F+ LH
Sbjct: 658 IPEDLEAFIELH 669
>gi|7657265 fem-1 homolog b [Homo sapiens]
Length = 627
Score = 426 bits (1095), Expect = e-119
Identities = 254/632 (40%), Positives = 374/632 (59%), Gaps = 34/632 (5%)
Query: 7 VFNAARDGKLRLLTKLLASKSKEEVSSLIS----EKTNGATPLLMAARYGHLDMVEFLLE 62
V+ AA +GK+ L LL ++S+ ++ L+ + +TPL++AAR GH +V LLE
Sbjct: 8 VYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLE 67
Query: 63 QCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRA 122
+ G+V FDG I+GA LW A+ AGH +VV+ L++HGA+VN+TT+TNSTPLRA
Sbjct: 68 HYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRA 127
Query: 123 ACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKG 182
ACFDG L+IVKYLVE+ A++ ++N++ +TCLMI+ YKGH ++ +YLLE+ AD N K+ G
Sbjct: 128 ACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCG 187
Query: 183 NTALHDCAESGSLDIMKMLLMYCAKMEKDGYGMTPLLSASVTGHTNIVDFLTHHAQTSKT 242
TALH AE+G +DI+K L+ + A + +G+GMTPL A+ + ++V+ L HA +
Sbjct: 188 ATALHFAAEAGHIDIVKELIKWRAAIVVNGHGMTPLKVAAESCKADVVELLLSHADCDRR 247
Query: 243 ERINALELLGATFVDKKR--DLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAK 300
RI ALELLGA+F + + D++ Y AM R+ D NI+ K V I AY
Sbjct: 248 SRIEALELLGASFANDRENYDIIKTYHYLYLAMLERFQDGDNILEKEVLPP-IHAYGNRT 306
Query: 301 EVNSAEELEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINL 360
E + +ELE + D D + M+ L++RERILG + D S+ I YRGAVYAD+ F++CI L
Sbjct: 307 ECRNPQELESIRQDRDALHMEGLIVRERILGADNIDVSHPIIYRGAVYADNMEFEQCIKL 366
Query: 361 WKYALDMQQSNLDPLSPMTASSLLSFAELFSFMLQDRAKGLLGTTVTFDDLMGILCKSVL 420
W +AL ++Q + T LL FA++FS M+ L TV D+ +L SVL
Sbjct: 367 WLHALHLRQKG----NRNTHKDLLRFAQVFSQMIH------LNETVKAPDIECVLRCSVL 416
Query: 421 EIERAIKQTQCPADPLQLNKA------LSIILHLICLLEKVPCTLEQDHFKKQTIYRFLK 474
EIE+++ + + +D N L L+L+C+ K C+ E + IY +
Sbjct: 417 EIEQSMNRVKNISDADVHNAMDNYECNLYTFLYLVCISTKTQCSEEDQCKINKQIYNLIH 476
Query: 475 LHPRGKNNFSPLHLAVDKNTTCVGRY--PVCKFPSLQVTAILIECGADVNVRDSDDNSPL 532
L PR + F+ LHLAV+ NT + VC FP+ VT +L++CGA+VN D++ NS L
Sbjct: 477 LDPRTREGFTLLHLAVNSNTPVDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSAL 536
Query: 533 HIAALNNHP--DIMNL------LIKSGAHFDATNLHKQTASDLLDEKEIAKNLIQPINHT 584
HI N P D + L L+++GAH D TN +T D +++ L++
Sbjct: 537 HIIVQYNRPISDFLTLHSIIISLVEAGAHTDMTNKQNKTPLD-KSTTGVSEILLKTQMKM 595
Query: 585 TLQCLAARVIVNHRIYYKGHIPEKLETFVSLH 616
+L+CLAAR + + I Y+ IP LE FV H
Sbjct: 596 SLKCLAARAVRANDINYQDQIPRTLEEFVGFH 627
>gi|169218177 PREDICTED: similar to fem-1 homolog a, partial [Homo
sapiens]
Length = 287
Score = 363 bits (933), Expect = e-100
Identities = 183/286 (63%), Positives = 222/286 (77%), Gaps = 1/286 (0%)
Query: 332 PSHPDTSYYIRYRGAVYADSGNFKRCINLWKYALDMQQSNLDPLSPMTASSLLSFAELFS 391
PSHPDTSY IRYRGAVYADSGN + I LWKYALDMQQSNL+PL+PM+ASS LSFAELFS
Sbjct: 2 PSHPDTSYCIRYRGAVYADSGNIECYIRLWKYALDMQQSNLEPLTPMSASSFLSFAELFS 61
Query: 392 FMLQD-RAKGLLGTTVTFDDLMGILCKSVLEIERAIKQTQCPADPLQLNKALSIILHLIC 450
++LQD AKG LGT + F DLMG+L K V E+E A++ + P D Q NKAL+IILHL+
Sbjct: 62 YVLQDPAAKGSLGTQIGFADLMGVLTKRVREVEWALQLLREPRDSAQFNKALAIILHLLY 121
Query: 451 LLEKVPCTLEQDHFKKQTIYRFLKLHPRGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQV 510
LLEKV CT Q+H K QTIYR LK PRGKN F+PLH+AVDK+TT VGRYPV +FPSL V
Sbjct: 122 LLEKVECTPSQEHLKHQTIYRLLKCAPRGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHV 181
Query: 511 TAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTASDLLDE 570
+L +CGAD + RD D+N+PLHIAA NN P I+N L ++GAH DATN K+TA +LL+E
Sbjct: 182 VKVLFDCGADRDSRDFDNNTPLHIAAQNNCPAIVNALTEAGAHMDATNAFKKTAYELLEE 241
Query: 571 KEIAKNLIQPINHTTLQCLAARVIVNHRIYYKGHIPEKLETFVSLH 616
K +A+ +QP N+ TLQCLAA+ + ++I YKG IPE LE F+ LH
Sbjct: 242 KLLARGTMQPFNYVTLQCLAAQALDKNKIPYKGFIPEDLEAFIELH 287
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 129 bits (325), Expect = 6e-30
Identities = 91/289 (31%), Positives = 147/289 (50%), Gaps = 22/289 (7%)
Query: 4 KTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQ 63
+T + NAA G L ++ L++ + E+ E +G TPL +AAR GH +V L
Sbjct: 546 RTLLANAAYSGSLDVVNLLVSRGADLEI-----EDAHGHTPLTLAARQGHTKVVNCL--- 597
Query: 64 CSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAA 123
+G N + +G L +A+ GH +VV +LL G V+ + T LRAA
Sbjct: 598 ------IGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAA 651
Query: 124 CFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGN 183
+ GH +IV L++H A++ ++ G T L+ + Y GH+EI ++LL+ GA+VN + V G
Sbjct: 652 AWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGR 711
Query: 184 TALHDC-----AESGSLDIMKMLLMYCAKMEK-DGYGMTPLLSASVTGHTNIVDFLTH-H 236
TAL A G ++ +L+ A+++ D GMTPLL A+ GH ++VD L
Sbjct: 712 TALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGG 771
Query: 237 AQTSKTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNIIS 285
A T+ LL A + ++ L +W A++ S+ ++S
Sbjct: 772 ADVDHTDNNGRTPLLAAASMG-HASVVNTLLFWGAAVDSIDSEGRTVLS 819
Score = 103 bits (257), Expect = 5e-22
Identities = 75/236 (31%), Positives = 119/236 (50%), Gaps = 21/236 (8%)
Query: 13 DGKLRLLTKLL---ASKSKEEVSSLISEK--------TNGATPLLMAARYGHLDMVEFLL 61
DG+ L L ASK V SL+ ++ +G TPLL+AA GH+D+V+ LL
Sbjct: 709 DGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLL 768
Query: 62 EQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLR 121
E G + D G PL AA++ GH VV +LL GA+V++ T L
Sbjct: 769 E---------GGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLS 819
Query: 122 AACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVK 181
A G++E+V+ L++ D + G T L ++ ++GH+ I + L+E+GA N
Sbjct: 820 IASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDND 879
Query: 182 GNTALHDCAESGSLDIMKMLLMYCAKMEKDGY-GMTPLLSASVTGHTNIVDFLTHH 236
G ++ G D +++LL + +++ GY G L A++ GH +IV+ L H
Sbjct: 880 GRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSH 935
Score = 103 bits (256), Expect = 6e-22
Identities = 61/198 (30%), Positives = 99/198 (50%), Gaps = 10/198 (5%)
Query: 40 NGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVV 99
+G P ++A++ GH D V+ LLE S N D +G L A+ GH +V
Sbjct: 879 DGRIPFILASQEGHYDCVQILLENKS---------NIDQRGYDGRNALRVAALEGHRDIV 929
Query: 100 QSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYK 159
+ L +HGA VN L + L + +Y +E+ A++E S+ G T L +SC++
Sbjct: 930 ELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQ 989
Query: 160 GHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKMEKD-GYGMTPL 218
GH E+ Q L+ ADVN + +AL A G + ++++L+ + A ++ G T L
Sbjct: 990 GHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATAL 1049
Query: 219 LSASVTGHTNIVDFLTHH 236
A+ GH ++V L H
Sbjct: 1050 CIAAQEGHIDVVQVLLEH 1067
Score = 100 bits (248), Expect = 5e-21
Identities = 77/249 (30%), Positives = 124/249 (49%), Gaps = 18/249 (7%)
Query: 2 DLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLL 61
D +TA+ AA G ++ LL + EV+ +E G T L+ AA GH ++VE LL
Sbjct: 643 DSRTALRAAAWGGHEDIVLNLLQHGA--EVNKADNE---GRTALIAAAYMGHREIVEHLL 697
Query: 62 EQCSASIEVGGSVNF---DGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNST 118
+ G VN DG T L ++ GH VV L++ GA V++ T
Sbjct: 698 DH-------GAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMT 750
Query: 119 PLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRK 178
PL A ++GH+++V L+E AD++ ++ +G T L+ + GH + LL GA V+
Sbjct: 751 PLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSI 810
Query: 179 SVKGNTALHDCAESGSLDIMKMLL-MYCAKMEKDGYGMTPLLSASVTGHTNIVDFLTHHA 237
+G T L + G++++++ LL + +D G TPL A+ GH I + L
Sbjct: 811 DSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIE-- 868
Query: 238 QTSKTERIN 246
Q ++T I+
Sbjct: 869 QGARTNEID 877
Score = 90.5 bits (223), Expect = 4e-18
Identities = 53/160 (33%), Positives = 86/160 (53%), Gaps = 2/160 (1%)
Query: 99 VQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCY 158
+++LL++GASVN T L A + G L++V LV ADLE+ + HGHT L ++
Sbjct: 528 IRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAAR 587
Query: 159 KGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTP 217
+GH ++ L+ GA++N G TAL A G +++ LL K++ D T
Sbjct: 588 QGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTA 647
Query: 218 LLSASVTGHTNIV-DFLTHHAQTSKTERINALELLGATFV 256
L +A+ GH +IV + L H A+ +K + L+ A ++
Sbjct: 648 LRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYM 687
Score = 87.4 bits (215), Expect = 3e-17
Identities = 53/167 (31%), Positives = 84/167 (50%), Gaps = 9/167 (5%)
Query: 40 NGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVV 99
+G L + A L M E+ LE N + EG L + GH+++V
Sbjct: 945 DGRPTLYILALENQLTMAEYFLEN---------GANVEASDAEGRTALHVSCWQGHMEMV 995
Query: 100 QSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYK 159
Q L+ + A VN + L++A + GH+++V+ L+EH A ++ + G T L I+ +
Sbjct: 996 QVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQE 1055
Query: 160 GHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCA 206
GH ++ Q LLE GAD N G TA+ A++G I+K+L Y A
Sbjct: 1056 GHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGA 1102
Score = 60.1 bits (144), Expect = 6e-09
Identities = 48/152 (31%), Positives = 77/152 (50%), Gaps = 7/152 (4%)
Query: 86 PLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLR---AACFDGHLEIVKYLVEHKADL 142
PL A A HL + +L A + + N TP+R + E+++ LV KA
Sbjct: 449 PLEAQEFALHL-INSNLQLETAELALWMIWNGTPVRDSLSTLIPKEQEVLQLLV--KAGA 505
Query: 143 EVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLL 202
V++ T ++ ++ + LL+ GA VN+ G T L + A SGSLD++ +L+
Sbjct: 506 HVNSEDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLV 565
Query: 203 MYCAKME-KDGYGMTPLLSASVTGHTNIVDFL 233
A +E +D +G TPL A+ GHT +V+ L
Sbjct: 566 SRGADLEIEDAHGHTPLTLAARQGHTKVVNCL 597
Score = 43.5 bits (101), Expect = 6e-04
Identities = 21/54 (38%), Positives = 36/54 (66%)
Query: 510 VTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQT 563
V ++LI+ GA+V+ D D +PL +AA H D+++LL++ GA D T+ + +T
Sbjct: 730 VVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRT 783
Score = 42.4 bits (98), Expect = 0.001
Identities = 21/58 (36%), Positives = 34/58 (58%)
Query: 507 SLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTA 564
SL V +L+ GAD+ + D+ ++PL +AA H ++N LI GA+ + T+ TA
Sbjct: 557 SLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTA 614
Score = 38.9 bits (89), Expect = 0.014
Identities = 18/55 (32%), Positives = 32/55 (58%)
Query: 510 VTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTA 564
+ +L GADVN +D+D L+I AL N + +++GA+ +A++ +TA
Sbjct: 928 IVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTA 982
Score = 38.5 bits (88), Expect = 0.018
Identities = 23/73 (31%), Positives = 39/73 (53%), Gaps = 3/73 (4%)
Query: 491 DKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKS 550
D T+C+ R + + S++ L++ GA VN DS+ + L AA + D++NLL+
Sbjct: 511 DDRTSCIVRQALEREDSIRT---LLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSR 567
Query: 551 GAHFDATNLHKQT 563
GA + + H T
Sbjct: 568 GADLEIEDAHGHT 580
Score = 37.7 bits (86), Expect = 0.031
Identities = 22/74 (29%), Positives = 37/74 (50%), Gaps = 3/74 (4%)
Query: 509 QVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTASDLL 568
+V LI CGA++N D D + L AA H ++++ L+ +G D + +TA
Sbjct: 592 KVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAA 651
Query: 569 ---DEKEIAKNLIQ 579
++I NL+Q
Sbjct: 652 AWGGHEDIVLNLLQ 665
Score = 37.0 bits (84), Expect = 0.054
Identities = 19/50 (38%), Positives = 28/50 (56%)
Query: 508 LQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDAT 557
+++ +LI ADVN D++ S L AA H ++ LLI+ GA D T
Sbjct: 992 MEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHT 1041
Score = 36.2 bits (82), Expect = 0.092
Identities = 21/74 (28%), Positives = 39/74 (52%), Gaps = 3/74 (4%)
Query: 508 LQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTASDL 567
+ V +L+E GADV+ D++ +PL AA H ++N L+ GA D+ + +T +
Sbjct: 761 VDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSI 820
Query: 568 LDEK---EIAKNLI 578
+ E+ + L+
Sbjct: 821 ASAQGNVEVVRTLL 834
Score = 36.2 bits (82), Expect = 0.092
Identities = 24/69 (34%), Positives = 34/69 (49%), Gaps = 3/69 (4%)
Query: 487 HLAVDKNTTCVGRYPVC---KFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDI 543
H AV +T G +C + + V +L+E GAD N D + + +AA N H I
Sbjct: 1034 HGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQI 1093
Query: 544 MNLLIKSGA 552
+ LL K GA
Sbjct: 1094 IKLLEKYGA 1102
Score = 35.0 bits (79), Expect = 0.20
Identities = 22/81 (27%), Positives = 41/81 (50%), Gaps = 6/81 (7%)
Query: 509 QVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQT---AS 565
+V + L+ G V+ D+D + L AA H DI+ L++ GA + + +T A+
Sbjct: 625 EVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAA 684
Query: 566 DLLDEKEIAKNLIQ---PINH 583
+ +EI ++L+ +NH
Sbjct: 685 AYMGHREIVEHLLDHGAEVNH 705
Score = 35.0 bits (79), Expect = 0.20
Identities = 18/46 (39%), Positives = 26/46 (56%)
Query: 507 SLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGA 552
+++V L++ G D N RD +PLH+AA H I LI+ GA
Sbjct: 826 NVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGA 871
Score = 33.1 bits (74), Expect = 0.78
Identities = 16/40 (40%), Positives = 24/40 (60%)
Query: 513 ILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGA 552
IL+E ++++ R D + L +AAL H DI+ LL GA
Sbjct: 898 ILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGA 937
Score = 32.7 bits (73), Expect = 1.0
Identities = 18/52 (34%), Positives = 28/52 (53%), Gaps = 5/52 (9%)
Query: 509 QVTAILIECGADVNVRDSDDNSPLHIAAL-----NNHPDIMNLLIKSGAHFD 555
++ L++ GA+VN D D + L +AAL H +++LLI GA D
Sbjct: 691 EIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVD 742
Score = 32.3 bits (72), Expect = 1.3
Identities = 15/57 (26%), Positives = 31/57 (54%)
Query: 508 LQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTA 564
L + +E GA+V D++ + LH++ H +++ +LI A +A + K++A
Sbjct: 959 LTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSA 1015
Score = 31.6 bits (70), Expect = 2.3
Identities = 23/85 (27%), Positives = 40/85 (47%), Gaps = 13/85 (15%)
Query: 471 RFLKLHPRGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNS 530
R L + R ++PLH+A + G +C+ LIE GA N D+D
Sbjct: 836 RGLDENHRDDAGWTPLHMAAFE-----GHRLICE--------ALIEQGARTNEIDNDGRI 882
Query: 531 PLHIAALNNHPDIMNLLIKSGAHFD 555
P +A+ H D + +L+++ ++ D
Sbjct: 883 PFILASQEGHYDCVQILLENKSNID 907
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 115 bits (289), Expect = 9e-26
Identities = 136/595 (22%), Positives = 240/595 (40%), Gaps = 79/595 (13%)
Query: 2 DLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLL 61
D T + AAR+G +R+ LL + + + ++ NG +P+ MAA+ HLD V LL
Sbjct: 304 DELTPLHCAARNGHVRISEILL-----DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLL 358
Query: 62 EQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLR 121
+ D T++ PL A+ GH +V + LL+ GA N+ L TPL
Sbjct: 359 QY---------DAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 409
Query: 122 AACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVK 181
AC H+ +++ L++ A ++ G T L ++ + GH I + LL++GA N +VK
Sbjct: 410 IACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVK 469
Query: 182 GNTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFLTHHAQTS 240
T LH A +G ++ K LL AK+ K TPL A+ GHTN+V L +
Sbjct: 470 VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN---- 525
Query: 241 KTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTN-IISKPVPQTLIMAYDYA 299
NA L T + + + + + + + ++K L +A Y
Sbjct: 526 -----NANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG 580
Query: 300 KEVNSAEELEGLIADPDEMRMQAL----------------LIRERILGPSHPDTSYYIRY 343
K V AE L A P+ L L+ R P P + Y
Sbjct: 581 K-VRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPL 639
Query: 344 RGAVYADSGNFKRCINLWKYALDMQQSNLDPLSPMTASSLLSFAELFSFMLQDRAKGLLG 403
+ A + +L +Y ++ ++P+ ++ AE+ + +L +A G LG
Sbjct: 640 H--IAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 697
Query: 404 TTVTFDDLMGILCKSVLEIERAIKQTQCPADPLQLNKALSIILHLICLLEKVPCTLEQDH 463
+ + ++ P + + +++ + P + H
Sbjct: 698 NK-----------SGLTPLHLVAQEGHVPVADVLIKH--GVMVDATTRMGYTPLHV-ASH 743
Query: 464 FKKQTIYRFLKLH-----PRGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECG 518
+ + +FL H + K +SPLH A + T + +L++ G
Sbjct: 744 YGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHT-------------DIVTLLLKNG 790
Query: 519 ADVNVRDSDDNSPLHIAALNNH---PDIMNLLIKSGAHFDATNLHKQTASDLLDE 570
A N SD +PL IA + D++ ++ + ++ H+ + + +DE
Sbjct: 791 ASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDE 845
Score = 102 bits (255), Expect = 8e-22
Identities = 78/236 (33%), Positives = 114/236 (48%), Gaps = 19/236 (8%)
Query: 1 MDLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFL 60
+D T + AA G R+ LL +K +L NG TPL +A + H+ ++E L
Sbjct: 369 LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRAL-----NGFTPLHIACKKNHVRVMELL 423
Query: 61 LEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPL 120
L+ G S+ D T G PL AS GHL +V++LL GAS N + + TPL
Sbjct: 424 LK-------TGASI--DAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 474
Query: 121 RAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSV 180
A GH E+ KYL+++KA + + T L + GH + + LLE A+ N +
Sbjct: 475 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 534
Query: 181 KGNTALHDCAESGSLDIMKMLLMYCAK---MEKDGYGMTPLLSASVTGHTNIVDFL 233
G+T LH A G ++ + LL A M K G+ TPL A+ G + + L
Sbjct: 535 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF--TPLHVAAKYGKVRVAELL 588
Score = 101 bits (251), Expect = 2e-21
Identities = 137/633 (21%), Positives = 254/633 (40%), Gaps = 94/633 (14%)
Query: 5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLL--- 61
T ++ AA++ L ++ LL + + + V++ +G TPL +A + GH ++V L+
Sbjct: 146 TPLYMAAQENHLEVVKFLLENGANQNVAT-----EDGFTPLAVALQQGHENVVAHLINYG 200
Query: 62 -----------------EQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLN 104
+ +A++ + N D + G PL A+ +L V Q LLN
Sbjct: 201 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 260
Query: 105 HGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEI 164
GASVN T TPL A G++ +V+ L++ A +E + T L + GH I
Sbjct: 261 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI 320
Query: 165 AQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKMEKDGYG-MTPLLSASV 223
++ LL+ GA + K+ G + +H A+ LD +++LL Y A+++ +TPL A+
Sbjct: 321 SEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAH 380
Query: 224 TGHTNIVDFLTHHAQTSKTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNI 283
GH + L K + N+ L G T + + K + M + +I
Sbjct: 381 CGHHRVAKVLL-----DKGAKPNSRALNGFTPLH-----IACKKNHVRVMELLLKTGASI 430
Query: 284 ISKPVPQTLIMAYDYAKEVNSAEELEGLI---ADPDEMRMQALLIRERILGPSHPDTSYY 340
+ V ++ + A + ++ L+ A P+ ++ H + + Y
Sbjct: 431 DA--VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 488
Query: 341 IRYRGAVYADSGNFKRCINLWKYALDMQQSNLDPLSPMTASSLLSFAELFSFMLQDRAKG 400
+ A + D +P+ ++ + + +L++ A
Sbjct: 489 LLQNKA-------------------KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 529
Query: 401 LLGTTVTFDDLMGILCKSVLEIERAIKQTQCPADPLQLNKALSIILHLICLLEKVPCT-- 458
L TT L + +E A+ + + A + K LH+ KV
Sbjct: 530 NLATTAGHTPLHIAAREGHVETVLALLEKE--ASQACMTKKGFTPLHVAAKYGKVRVAEL 587
Query: 459 -LEQDHFKKQTIYRFLKLHPR--GKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILI 515
LE+D HP GKN +PLH+AV N +L + +L+
Sbjct: 588 LLERD------------AHPNAAGKNGLTPLHVAVHHN-------------NLDIVKLLL 622
Query: 516 ECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTASDLLDEKEIAK 575
G + + +PLHIAA N ++ L++ G +A ++ T L ++ A+
Sbjct: 623 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 682
Query: 576 NLIQPINHTTLQCLAAR--VIVNHRIYYKGHIP 606
+ ++ L + + H + +GH+P
Sbjct: 683 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 715
Score = 97.8 bits (242), Expect = 3e-20
Identities = 135/573 (23%), Positives = 233/573 (40%), Gaps = 84/573 (14%)
Query: 36 SEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGH 95
++ G TPL MAA+ HL++V+FLLE N + T +G PL A GH
Sbjct: 139 AQSQKGFTPLYMAAQENHLEVVKFLLEN---------GANQNVATEDGFTPLAVALQQGH 189
Query: 96 LKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMI 155
VV L+N+G L A + L+++ + +V ++ G T L I
Sbjct: 190 ENVVAHLINYGTKGK----VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHI 245
Query: 156 SCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKME-KDGYG 214
+ + + +AQ LL +GA VN G T LH + G++ ++++LL A++E K
Sbjct: 246 AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 305
Query: 215 MTPLLSASVTGHTNIVDFLTHHAQTSKTERINALELLGATFVDKKRDLLGALKYWKKAMN 274
+TPL A+ GH I + L H + + N L + D + L + ++
Sbjct: 306 LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 365
Query: 275 MRYSDRTNII-------SKPVPQTLI--MAYDYAKEVNSAEELEGLIADPDEMRMQALLI 325
D + V + L+ A ++ +N L + + +R+ LL+
Sbjct: 366 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH-IACKKNHVRVMELLL 424
Query: 326 R---------ERILGPSHPDTSYYIRYRGAVYADSGNFKRCINLWKYALDMQQSNLDPLS 376
+ E L P H V + G+ NL + SN+ +
Sbjct: 425 KTGASIDAVTESGLTPLH------------VASFMGHLPIVKNLLQRGASPNVSNVKVET 472
Query: 377 PMTASSLLSFAELFSFMLQDRAKGLLGTTVTFDDLMGILCKSVLEIERAIK-QTQCPADP 435
P+ ++ E+ ++LQ++AK DD + C + + +K + A+P
Sbjct: 473 PLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 529
Query: 436 LQLNKALSIILHLICL---LEKVPCTLEQDHFKKQTIYRFLKLHPRGKNNFSPLHLAVDK 492
A LH+ +E V LE++ + K F+PLH+A
Sbjct: 530 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT----------KKGFTPLHVA--- 576
Query: 493 NTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGA 552
K+ ++V +L+E A N + +PLH+A +N+ DI+ LL+ G
Sbjct: 577 ----------AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 626
Query: 553 --HFDATN----LHKQTASDLLDEKEIAKNLIQ 579
H A N LH ++ E+A++L+Q
Sbjct: 627 SPHSPAWNGYTPLHIAAKQ---NQVEVARSLLQ 656
Score = 92.8 bits (229), Expect = 8e-19
Identities = 139/608 (22%), Positives = 234/608 (38%), Gaps = 93/608 (15%)
Query: 2 DLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKT---NGATPLLMAARYGHLDMVE 58
D T+ AAR G L K+ + + + + T NG L +A++ GH+ MV
Sbjct: 44 DAATSFLRAARSGNL--------DKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVV 95
Query: 59 FLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNST 118
LL + + + T +G L A+ AG +VV+ L+N+GA+VN + T
Sbjct: 96 ELLHK---------EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFT 146
Query: 119 PLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRK 178
PL A + HLE+VK+L+E+ A+ V+ G T L ++ +GH+ + +L+ G K
Sbjct: 147 PLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT----K 202
Query: 179 SVKGNTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFLTHHA 237
ALH A + +LL + G TPL A+ + N+ L +
Sbjct: 203 GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 262
Query: 238 QTSKTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYD 297
+ N + L S R N+I L++
Sbjct: 263 ASVNFTPQNGITPLHIA-----------------------SRRGNVIM----VRLLLDRG 295
Query: 298 YAKEVNSAEELEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVY-ADSGNFKR 356
E + +EL L R + I E +L P + ++ A G+
Sbjct: 296 AQIETKTKDELTPLHC---AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 352
Query: 357 CIN-LWKYALDMQQSNLDPLSPMTASSLLSFAELFSFMLQDRAKGLLGTTVTFDDLMGIL 415
C+ L +Y ++ LD L+P+ ++ + +L AK F L
Sbjct: 353 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIAC 412
Query: 416 CKSVLEIERAIKQTQCPADPLQLNKALSIILHLICLLEKVPCTLEQDHFKKQTIYRFLKL 475
K+ + + + +T D + ++ LH+ + +P K + R
Sbjct: 413 KKNHVRVMELLLKTGASID--AVTESGLTPLHVASFMGHLPIV-------KNLLQRGASP 463
Query: 476 HPRGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIA 535
+ +PLH+A T V +Y L++ A VN + DD +PLH A
Sbjct: 464 NVSNVKVETPLHMAARAGHTEVAKY-------------LLQNKAKVNAKAKDDQTPLHCA 510
Query: 536 ALNNHPDIMNLLIKSGA-------------HFDATNLHKQTASDLLDEKEIAKNLIQPIN 582
A H +++ LL+++ A H A H +T LL EKE ++ +
Sbjct: 511 ARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL-EKEASQACMTKKG 569
Query: 583 HTTLQCLA 590
T L A
Sbjct: 570 FTPLHVAA 577
Score = 73.2 bits (178), Expect = 7e-13
Identities = 51/171 (29%), Positives = 82/171 (47%), Gaps = 9/171 (5%)
Query: 37 EKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHL 96
+K + AT L AAR G+LD A + V+ + G L AS GH+
Sbjct: 41 KKADAATSFLRAARSGNLD---------KALDHLRNGVDINTCNQNGLNGLHLASKEGHV 91
Query: 97 KVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMIS 156
K+V LL+ + TT +T L A G E+V+ LV + A++ ++ G T L ++
Sbjct: 92 KMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMA 151
Query: 157 CYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAK 207
+ H E+ ++LLE GA+ N + G T L + G +++ L+ Y K
Sbjct: 152 AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK 202
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 115 bits (289), Expect = 9e-26
Identities = 136/595 (22%), Positives = 240/595 (40%), Gaps = 79/595 (13%)
Query: 2 DLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLL 61
D T + AAR+G +R+ LL + + + ++ NG +P+ MAA+ HLD V LL
Sbjct: 271 DELTPLHCAARNGHVRISEILL-----DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLL 325
Query: 62 EQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLR 121
+ D T++ PL A+ GH +V + LL+ GA N+ L TPL
Sbjct: 326 QY---------DAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 376
Query: 122 AACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVK 181
AC H+ +++ L++ A ++ G T L ++ + GH I + LL++GA N +VK
Sbjct: 377 IACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVK 436
Query: 182 GNTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFLTHHAQTS 240
T LH A +G ++ K LL AK+ K TPL A+ GHTN+V L +
Sbjct: 437 VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN---- 492
Query: 241 KTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTN-IISKPVPQTLIMAYDYA 299
NA L T + + + + + + + ++K L +A Y
Sbjct: 493 -----NANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG 547
Query: 300 KEVNSAEELEGLIADPDEMRMQAL----------------LIRERILGPSHPDTSYYIRY 343
K V AE L A P+ L L+ R P P + Y
Sbjct: 548 K-VRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPL 606
Query: 344 RGAVYADSGNFKRCINLWKYALDMQQSNLDPLSPMTASSLLSFAELFSFMLQDRAKGLLG 403
+ A + +L +Y ++ ++P+ ++ AE+ + +L +A G LG
Sbjct: 607 H--IAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664
Query: 404 TTVTFDDLMGILCKSVLEIERAIKQTQCPADPLQLNKALSIILHLICLLEKVPCTLEQDH 463
+ + ++ P + + +++ + P + H
Sbjct: 665 NK-----------SGLTPLHLVAQEGHVPVADVLIKH--GVMVDATTRMGYTPLHV-ASH 710
Query: 464 FKKQTIYRFLKLH-----PRGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECG 518
+ + +FL H + K +SPLH A + T + +L++ G
Sbjct: 711 YGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHT-------------DIVTLLLKNG 757
Query: 519 ADVNVRDSDDNSPLHIAALNNH---PDIMNLLIKSGAHFDATNLHKQTASDLLDE 570
A N SD +PL IA + D++ ++ + ++ H+ + + +DE
Sbjct: 758 ASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDE 812
Score = 102 bits (255), Expect = 8e-22
Identities = 78/236 (33%), Positives = 114/236 (48%), Gaps = 19/236 (8%)
Query: 1 MDLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFL 60
+D T + AA G R+ LL +K +L NG TPL +A + H+ ++E L
Sbjct: 336 LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRAL-----NGFTPLHIACKKNHVRVMELL 390
Query: 61 LEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPL 120
L+ G S+ D T G PL AS GHL +V++LL GAS N + + TPL
Sbjct: 391 LK-------TGASI--DAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441
Query: 121 RAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSV 180
A GH E+ KYL+++KA + + T L + GH + + LLE A+ N +
Sbjct: 442 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 501
Query: 181 KGNTALHDCAESGSLDIMKMLLMYCAK---MEKDGYGMTPLLSASVTGHTNIVDFL 233
G+T LH A G ++ + LL A M K G+ TPL A+ G + + L
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF--TPLHVAAKYGKVRVAELL 555
Score = 101 bits (251), Expect = 2e-21
Identities = 137/633 (21%), Positives = 254/633 (40%), Gaps = 94/633 (14%)
Query: 5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLL--- 61
T ++ AA++ L ++ LL + + + V++ +G TPL +A + GH ++V L+
Sbjct: 113 TPLYMAAQENHLEVVKFLLENGANQNVAT-----EDGFTPLAVALQQGHENVVAHLINYG 167
Query: 62 -----------------EQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLN 104
+ +A++ + N D + G PL A+ +L V Q LLN
Sbjct: 168 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 227
Query: 105 HGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEI 164
GASVN T TPL A G++ +V+ L++ A +E + T L + GH I
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI 287
Query: 165 AQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKMEKDGYG-MTPLLSASV 223
++ LL+ GA + K+ G + +H A+ LD +++LL Y A+++ +TPL A+
Sbjct: 288 SEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAH 347
Query: 224 TGHTNIVDFLTHHAQTSKTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNI 283
GH + L K + N+ L G T + + K + M + +I
Sbjct: 348 CGHHRVAKVLL-----DKGAKPNSRALNGFTPLH-----IACKKNHVRVMELLLKTGASI 397
Query: 284 ISKPVPQTLIMAYDYAKEVNSAEELEGLI---ADPDEMRMQALLIRERILGPSHPDTSYY 340
+ V ++ + A + ++ L+ A P+ ++ H + + Y
Sbjct: 398 DA--VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 455
Query: 341 IRYRGAVYADSGNFKRCINLWKYALDMQQSNLDPLSPMTASSLLSFAELFSFMLQDRAKG 400
+ A + D +P+ ++ + + +L++ A
Sbjct: 456 LLQNKA-------------------KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496
Query: 401 LLGTTVTFDDLMGILCKSVLEIERAIKQTQCPADPLQLNKALSIILHLICLLEKVPCT-- 458
L TT L + +E A+ + + A + K LH+ KV
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKE--ASQACMTKKGFTPLHVAAKYGKVRVAEL 554
Query: 459 -LEQDHFKKQTIYRFLKLHPR--GKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILI 515
LE+D HP GKN +PLH+AV N +L + +L+
Sbjct: 555 LLERD------------AHPNAAGKNGLTPLHVAVHHN-------------NLDIVKLLL 589
Query: 516 ECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTASDLLDEKEIAK 575
G + + +PLHIAA N ++ L++ G +A ++ T L ++ A+
Sbjct: 590 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 649
Query: 576 NLIQPINHTTLQCLAAR--VIVNHRIYYKGHIP 606
+ ++ L + + H + +GH+P
Sbjct: 650 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682
Score = 97.8 bits (242), Expect = 3e-20
Identities = 135/573 (23%), Positives = 233/573 (40%), Gaps = 84/573 (14%)
Query: 36 SEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGH 95
++ G TPL MAA+ HL++V+FLLE N + T +G PL A GH
Sbjct: 106 AQSQKGFTPLYMAAQENHLEVVKFLLEN---------GANQNVATEDGFTPLAVALQQGH 156
Query: 96 LKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMI 155
VV L+N+G L A + L+++ + +V ++ G T L I
Sbjct: 157 ENVVAHLINYGTKGK----VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHI 212
Query: 156 SCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKME-KDGYG 214
+ + + +AQ LL +GA VN G T LH + G++ ++++LL A++E K
Sbjct: 213 AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272
Query: 215 MTPLLSASVTGHTNIVDFLTHHAQTSKTERINALELLGATFVDKKRDLLGALKYWKKAMN 274
+TPL A+ GH I + L H + + N L + D + L + ++
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332
Query: 275 MRYSDRTNII-------SKPVPQTLI--MAYDYAKEVNSAEELEGLIADPDEMRMQALLI 325
D + V + L+ A ++ +N L + + +R+ LL+
Sbjct: 333 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH-IACKKNHVRVMELLL 391
Query: 326 R---------ERILGPSHPDTSYYIRYRGAVYADSGNFKRCINLWKYALDMQQSNLDPLS 376
+ E L P H V + G+ NL + SN+ +
Sbjct: 392 KTGASIDAVTESGLTPLH------------VASFMGHLPIVKNLLQRGASPNVSNVKVET 439
Query: 377 PMTASSLLSFAELFSFMLQDRAKGLLGTTVTFDDLMGILCKSVLEIERAIK-QTQCPADP 435
P+ ++ E+ ++LQ++AK DD + C + + +K + A+P
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496
Query: 436 LQLNKALSIILHLICL---LEKVPCTLEQDHFKKQTIYRFLKLHPRGKNNFSPLHLAVDK 492
A LH+ +E V LE++ + K F+PLH+A
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT----------KKGFTPLHVA--- 543
Query: 493 NTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGA 552
K+ ++V +L+E A N + +PLH+A +N+ DI+ LL+ G
Sbjct: 544 ----------AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593
Query: 553 --HFDATN----LHKQTASDLLDEKEIAKNLIQ 579
H A N LH ++ E+A++L+Q
Sbjct: 594 SPHSPAWNGYTPLHIAAKQ---NQVEVARSLLQ 623
Score = 92.8 bits (229), Expect = 8e-19
Identities = 139/608 (22%), Positives = 234/608 (38%), Gaps = 93/608 (15%)
Query: 2 DLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKT---NGATPLLMAARYGHLDMVE 58
D T+ AAR G L K+ + + + + T NG L +A++ GH+ MV
Sbjct: 11 DAATSFLRAARSGNL--------DKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVV 62
Query: 59 FLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNST 118
LL + + + T +G L A+ AG +VV+ L+N+GA+VN + T
Sbjct: 63 ELLHK---------EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFT 113
Query: 119 PLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRK 178
PL A + HLE+VK+L+E+ A+ V+ G T L ++ +GH+ + +L+ G K
Sbjct: 114 PLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT----K 169
Query: 179 SVKGNTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFLTHHA 237
ALH A + +LL + G TPL A+ + N+ L +
Sbjct: 170 GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 229
Query: 238 QTSKTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYD 297
+ N + L S R N+I L++
Sbjct: 230 ASVNFTPQNGITPLHIA-----------------------SRRGNVIM----VRLLLDRG 262
Query: 298 YAKEVNSAEELEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVY-ADSGNFKR 356
E + +EL L R + I E +L P + ++ A G+
Sbjct: 263 AQIETKTKDELTPLHC---AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 319
Query: 357 CIN-LWKYALDMQQSNLDPLSPMTASSLLSFAELFSFMLQDRAKGLLGTTVTFDDLMGIL 415
C+ L +Y ++ LD L+P+ ++ + +L AK F L
Sbjct: 320 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIAC 379
Query: 416 CKSVLEIERAIKQTQCPADPLQLNKALSIILHLICLLEKVPCTLEQDHFKKQTIYRFLKL 475
K+ + + + +T D + ++ LH+ + +P K + R
Sbjct: 380 KKNHVRVMELLLKTGASID--AVTESGLTPLHVASFMGHLPIV-------KNLLQRGASP 430
Query: 476 HPRGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIA 535
+ +PLH+A T V +Y L++ A VN + DD +PLH A
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKY-------------LLQNKAKVNAKAKDDQTPLHCA 477
Query: 536 ALNNHPDIMNLLIKSGA-------------HFDATNLHKQTASDLLDEKEIAKNLIQPIN 582
A H +++ LL+++ A H A H +T LL EKE ++ +
Sbjct: 478 ARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL-EKEASQACMTKKG 536
Query: 583 HTTLQCLA 590
T L A
Sbjct: 537 FTPLHVAA 544
Score = 71.2 bits (173), Expect = 3e-12
Identities = 50/170 (29%), Positives = 81/170 (47%), Gaps = 9/170 (5%)
Query: 38 KTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLK 97
+ + AT L AAR G+LD A + V+ + G L AS GH+K
Sbjct: 9 EADAATSFLRAARSGNLD---------KALDHLRNGVDINTCNQNGLNGLHLASKEGHVK 59
Query: 98 VVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISC 157
+V LL+ + TT +T L A G E+V+ LV + A++ ++ G T L ++
Sbjct: 60 MVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA 119
Query: 158 YKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAK 207
+ H E+ ++LLE GA+ N + G T L + G +++ L+ Y K
Sbjct: 120 QENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK 169
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 115 bits (289), Expect = 9e-26
Identities = 136/595 (22%), Positives = 240/595 (40%), Gaps = 79/595 (13%)
Query: 2 DLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLL 61
D T + AAR+G +R+ LL + + + ++ NG +P+ MAA+ HLD V LL
Sbjct: 271 DELTPLHCAARNGHVRISEILL-----DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLL 325
Query: 62 EQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLR 121
+ D T++ PL A+ GH +V + LL+ GA N+ L TPL
Sbjct: 326 QY---------DAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 376
Query: 122 AACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVK 181
AC H+ +++ L++ A ++ G T L ++ + GH I + LL++GA N +VK
Sbjct: 377 IACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVK 436
Query: 182 GNTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFLTHHAQTS 240
T LH A +G ++ K LL AK+ K TPL A+ GHTN+V L +
Sbjct: 437 VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN---- 492
Query: 241 KTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTN-IISKPVPQTLIMAYDYA 299
NA L T + + + + + + + ++K L +A Y
Sbjct: 493 -----NANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG 547
Query: 300 KEVNSAEELEGLIADPDEMRMQAL----------------LIRERILGPSHPDTSYYIRY 343
K V AE L A P+ L L+ R P P + Y
Sbjct: 548 K-VRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPL 606
Query: 344 RGAVYADSGNFKRCINLWKYALDMQQSNLDPLSPMTASSLLSFAELFSFMLQDRAKGLLG 403
+ A + +L +Y ++ ++P+ ++ AE+ + +L +A G LG
Sbjct: 607 H--IAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664
Query: 404 TTVTFDDLMGILCKSVLEIERAIKQTQCPADPLQLNKALSIILHLICLLEKVPCTLEQDH 463
+ + ++ P + + +++ + P + H
Sbjct: 665 NK-----------SGLTPLHLVAQEGHVPVADVLIKH--GVMVDATTRMGYTPLHV-ASH 710
Query: 464 FKKQTIYRFLKLH-----PRGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECG 518
+ + +FL H + K +SPLH A + T + +L++ G
Sbjct: 711 YGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHT-------------DIVTLLLKNG 757
Query: 519 ADVNVRDSDDNSPLHIAALNNH---PDIMNLLIKSGAHFDATNLHKQTASDLLDE 570
A N SD +PL IA + D++ ++ + ++ H+ + + +DE
Sbjct: 758 ASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDE 812
Score = 102 bits (255), Expect = 8e-22
Identities = 78/236 (33%), Positives = 114/236 (48%), Gaps = 19/236 (8%)
Query: 1 MDLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFL 60
+D T + AA G R+ LL +K +L NG TPL +A + H+ ++E L
Sbjct: 336 LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRAL-----NGFTPLHIACKKNHVRVMELL 390
Query: 61 LEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPL 120
L+ G S+ D T G PL AS GHL +V++LL GAS N + + TPL
Sbjct: 391 LK-------TGASI--DAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441
Query: 121 RAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSV 180
A GH E+ KYL+++KA + + T L + GH + + LLE A+ N +
Sbjct: 442 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 501
Query: 181 KGNTALHDCAESGSLDIMKMLLMYCAK---MEKDGYGMTPLLSASVTGHTNIVDFL 233
G+T LH A G ++ + LL A M K G+ TPL A+ G + + L
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF--TPLHVAAKYGKVRVAELL 555
Score = 101 bits (251), Expect = 2e-21
Identities = 137/633 (21%), Positives = 254/633 (40%), Gaps = 94/633 (14%)
Query: 5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLL--- 61
T ++ AA++ L ++ LL + + + V++ +G TPL +A + GH ++V L+
Sbjct: 113 TPLYMAAQENHLEVVKFLLENGANQNVAT-----EDGFTPLAVALQQGHENVVAHLINYG 167
Query: 62 -----------------EQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLN 104
+ +A++ + N D + G PL A+ +L V Q LLN
Sbjct: 168 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 227
Query: 105 HGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEI 164
GASVN T TPL A G++ +V+ L++ A +E + T L + GH I
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI 287
Query: 165 AQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKMEKDGYG-MTPLLSASV 223
++ LL+ GA + K+ G + +H A+ LD +++LL Y A+++ +TPL A+
Sbjct: 288 SEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAH 347
Query: 224 TGHTNIVDFLTHHAQTSKTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNI 283
GH + L K + N+ L G T + + K + M + +I
Sbjct: 348 CGHHRVAKVLL-----DKGAKPNSRALNGFTPLH-----IACKKNHVRVMELLLKTGASI 397
Query: 284 ISKPVPQTLIMAYDYAKEVNSAEELEGLI---ADPDEMRMQALLIRERILGPSHPDTSYY 340
+ V ++ + A + ++ L+ A P+ ++ H + + Y
Sbjct: 398 DA--VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 455
Query: 341 IRYRGAVYADSGNFKRCINLWKYALDMQQSNLDPLSPMTASSLLSFAELFSFMLQDRAKG 400
+ A + D +P+ ++ + + +L++ A
Sbjct: 456 LLQNKA-------------------KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496
Query: 401 LLGTTVTFDDLMGILCKSVLEIERAIKQTQCPADPLQLNKALSIILHLICLLEKVPCT-- 458
L TT L + +E A+ + + A + K LH+ KV
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKE--ASQACMTKKGFTPLHVAAKYGKVRVAEL 554
Query: 459 -LEQDHFKKQTIYRFLKLHPR--GKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILI 515
LE+D HP GKN +PLH+AV N +L + +L+
Sbjct: 555 LLERD------------AHPNAAGKNGLTPLHVAVHHN-------------NLDIVKLLL 589
Query: 516 ECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTASDLLDEKEIAK 575
G + + +PLHIAA N ++ L++ G +A ++ T L ++ A+
Sbjct: 590 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 649
Query: 576 NLIQPINHTTLQCLAAR--VIVNHRIYYKGHIP 606
+ ++ L + + H + +GH+P
Sbjct: 650 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682
Score = 97.8 bits (242), Expect = 3e-20
Identities = 135/573 (23%), Positives = 233/573 (40%), Gaps = 84/573 (14%)
Query: 36 SEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGH 95
++ G TPL MAA+ HL++V+FLLE N + T +G PL A GH
Sbjct: 106 AQSQKGFTPLYMAAQENHLEVVKFLLEN---------GANQNVATEDGFTPLAVALQQGH 156
Query: 96 LKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMI 155
VV L+N+G L A + L+++ + +V ++ G T L I
Sbjct: 157 ENVVAHLINYGTKGK----VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHI 212
Query: 156 SCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKME-KDGYG 214
+ + + +AQ LL +GA VN G T LH + G++ ++++LL A++E K
Sbjct: 213 AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272
Query: 215 MTPLLSASVTGHTNIVDFLTHHAQTSKTERINALELLGATFVDKKRDLLGALKYWKKAMN 274
+TPL A+ GH I + L H + + N L + D + L + ++
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332
Query: 275 MRYSDRTNII-------SKPVPQTLI--MAYDYAKEVNSAEELEGLIADPDEMRMQALLI 325
D + V + L+ A ++ +N L + + +R+ LL+
Sbjct: 333 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH-IACKKNHVRVMELLL 391
Query: 326 R---------ERILGPSHPDTSYYIRYRGAVYADSGNFKRCINLWKYALDMQQSNLDPLS 376
+ E L P H V + G+ NL + SN+ +
Sbjct: 392 KTGASIDAVTESGLTPLH------------VASFMGHLPIVKNLLQRGASPNVSNVKVET 439
Query: 377 PMTASSLLSFAELFSFMLQDRAKGLLGTTVTFDDLMGILCKSVLEIERAIK-QTQCPADP 435
P+ ++ E+ ++LQ++AK DD + C + + +K + A+P
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496
Query: 436 LQLNKALSIILHLICL---LEKVPCTLEQDHFKKQTIYRFLKLHPRGKNNFSPLHLAVDK 492
A LH+ +E V LE++ + K F+PLH+A
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT----------KKGFTPLHVA--- 543
Query: 493 NTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGA 552
K+ ++V +L+E A N + +PLH+A +N+ DI+ LL+ G
Sbjct: 544 ----------AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593
Query: 553 --HFDATN----LHKQTASDLLDEKEIAKNLIQ 579
H A N LH ++ E+A++L+Q
Sbjct: 594 SPHSPAWNGYTPLHIAAKQ---NQVEVARSLLQ 623
Score = 92.8 bits (229), Expect = 8e-19
Identities = 139/608 (22%), Positives = 234/608 (38%), Gaps = 93/608 (15%)
Query: 2 DLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKT---NGATPLLMAARYGHLDMVE 58
D T+ AAR G L K+ + + + + T NG L +A++ GH+ MV
Sbjct: 11 DAATSFLRAARSGNL--------DKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVV 62
Query: 59 FLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNST 118
LL + + + T +G L A+ AG +VV+ L+N+GA+VN + T
Sbjct: 63 ELLHK---------EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFT 113
Query: 119 PLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRK 178
PL A + HLE+VK+L+E+ A+ V+ G T L ++ +GH+ + +L+ G K
Sbjct: 114 PLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT----K 169
Query: 179 SVKGNTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFLTHHA 237
ALH A + +LL + G TPL A+ + N+ L +
Sbjct: 170 GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 229
Query: 238 QTSKTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYD 297
+ N + L S R N+I L++
Sbjct: 230 ASVNFTPQNGITPLHIA-----------------------SRRGNVIM----VRLLLDRG 262
Query: 298 YAKEVNSAEELEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVY-ADSGNFKR 356
E + +EL L R + I E +L P + ++ A G+
Sbjct: 263 AQIETKTKDELTPLHC---AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 319
Query: 357 CIN-LWKYALDMQQSNLDPLSPMTASSLLSFAELFSFMLQDRAKGLLGTTVTFDDLMGIL 415
C+ L +Y ++ LD L+P+ ++ + +L AK F L
Sbjct: 320 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIAC 379
Query: 416 CKSVLEIERAIKQTQCPADPLQLNKALSIILHLICLLEKVPCTLEQDHFKKQTIYRFLKL 475
K+ + + + +T D + ++ LH+ + +P K + R
Sbjct: 380 KKNHVRVMELLLKTGASID--AVTESGLTPLHVASFMGHLPIV-------KNLLQRGASP 430
Query: 476 HPRGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIA 535
+ +PLH+A T V +Y L++ A VN + DD +PLH A
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKY-------------LLQNKAKVNAKAKDDQTPLHCA 477
Query: 536 ALNNHPDIMNLLIKSGA-------------HFDATNLHKQTASDLLDEKEIAKNLIQPIN 582
A H +++ LL+++ A H A H +T LL EKE ++ +
Sbjct: 478 ARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL-EKEASQACMTKKG 536
Query: 583 HTTLQCLA 590
T L A
Sbjct: 537 FTPLHVAA 544
Score = 71.2 bits (173), Expect = 3e-12
Identities = 50/170 (29%), Positives = 81/170 (47%), Gaps = 9/170 (5%)
Query: 38 KTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLK 97
+ + AT L AAR G+LD A + V+ + G L AS GH+K
Sbjct: 9 EADAATSFLRAARSGNLD---------KALDHLRNGVDINTCNQNGLNGLHLASKEGHVK 59
Query: 98 VVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISC 157
+V LL+ + TT +T L A G E+V+ LV + A++ ++ G T L ++
Sbjct: 60 MVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA 119
Query: 158 YKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAK 207
+ H E+ ++LLE GA+ N + G T L + G +++ L+ Y K
Sbjct: 120 QENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK 169
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 115 bits (289), Expect = 9e-26
Identities = 136/595 (22%), Positives = 240/595 (40%), Gaps = 79/595 (13%)
Query: 2 DLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLL 61
D T + AAR+G +R+ LL + + + ++ NG +P+ MAA+ HLD V LL
Sbjct: 271 DELTPLHCAARNGHVRISEILL-----DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLL 325
Query: 62 EQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLR 121
+ D T++ PL A+ GH +V + LL+ GA N+ L TPL
Sbjct: 326 QY---------DAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 376
Query: 122 AACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVK 181
AC H+ +++ L++ A ++ G T L ++ + GH I + LL++GA N +VK
Sbjct: 377 IACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVK 436
Query: 182 GNTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFLTHHAQTS 240
T LH A +G ++ K LL AK+ K TPL A+ GHTN+V L +
Sbjct: 437 VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN---- 492
Query: 241 KTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTN-IISKPVPQTLIMAYDYA 299
NA L T + + + + + + + ++K L +A Y
Sbjct: 493 -----NANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG 547
Query: 300 KEVNSAEELEGLIADPDEMRMQAL----------------LIRERILGPSHPDTSYYIRY 343
K V AE L A P+ L L+ R P P + Y
Sbjct: 548 K-VRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPL 606
Query: 344 RGAVYADSGNFKRCINLWKYALDMQQSNLDPLSPMTASSLLSFAELFSFMLQDRAKGLLG 403
+ A + +L +Y ++ ++P+ ++ AE+ + +L +A G LG
Sbjct: 607 H--IAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664
Query: 404 TTVTFDDLMGILCKSVLEIERAIKQTQCPADPLQLNKALSIILHLICLLEKVPCTLEQDH 463
+ + ++ P + + +++ + P + H
Sbjct: 665 NK-----------SGLTPLHLVAQEGHVPVADVLIKH--GVMVDATTRMGYTPLHV-ASH 710
Query: 464 FKKQTIYRFLKLH-----PRGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECG 518
+ + +FL H + K +SPLH A + T + +L++ G
Sbjct: 711 YGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHT-------------DIVTLLLKNG 757
Query: 519 ADVNVRDSDDNSPLHIAALNNH---PDIMNLLIKSGAHFDATNLHKQTASDLLDE 570
A N SD +PL IA + D++ ++ + ++ H+ + + +DE
Sbjct: 758 ASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDE 812
Score = 102 bits (255), Expect = 8e-22
Identities = 78/236 (33%), Positives = 114/236 (48%), Gaps = 19/236 (8%)
Query: 1 MDLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFL 60
+D T + AA G R+ LL +K +L NG TPL +A + H+ ++E L
Sbjct: 336 LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRAL-----NGFTPLHIACKKNHVRVMELL 390
Query: 61 LEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPL 120
L+ G S+ D T G PL AS GHL +V++LL GAS N + + TPL
Sbjct: 391 LK-------TGASI--DAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441
Query: 121 RAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSV 180
A GH E+ KYL+++KA + + T L + GH + + LLE A+ N +
Sbjct: 442 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 501
Query: 181 KGNTALHDCAESGSLDIMKMLLMYCAK---MEKDGYGMTPLLSASVTGHTNIVDFL 233
G+T LH A G ++ + LL A M K G+ TPL A+ G + + L
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF--TPLHVAAKYGKVRVAELL 555
Score = 101 bits (251), Expect = 2e-21
Identities = 137/633 (21%), Positives = 254/633 (40%), Gaps = 94/633 (14%)
Query: 5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLL--- 61
T ++ AA++ L ++ LL + + + V++ +G TPL +A + GH ++V L+
Sbjct: 113 TPLYMAAQENHLEVVKFLLENGANQNVAT-----EDGFTPLAVALQQGHENVVAHLINYG 167
Query: 62 -----------------EQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLN 104
+ +A++ + N D + G PL A+ +L V Q LLN
Sbjct: 168 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 227
Query: 105 HGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEI 164
GASVN T TPL A G++ +V+ L++ A +E + T L + GH I
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI 287
Query: 165 AQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKMEKDGYG-MTPLLSASV 223
++ LL+ GA + K+ G + +H A+ LD +++LL Y A+++ +TPL A+
Sbjct: 288 SEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAH 347
Query: 224 TGHTNIVDFLTHHAQTSKTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNI 283
GH + L K + N+ L G T + + K + M + +I
Sbjct: 348 CGHHRVAKVLL-----DKGAKPNSRALNGFTPLH-----IACKKNHVRVMELLLKTGASI 397
Query: 284 ISKPVPQTLIMAYDYAKEVNSAEELEGLI---ADPDEMRMQALLIRERILGPSHPDTSYY 340
+ V ++ + A + ++ L+ A P+ ++ H + + Y
Sbjct: 398 DA--VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 455
Query: 341 IRYRGAVYADSGNFKRCINLWKYALDMQQSNLDPLSPMTASSLLSFAELFSFMLQDRAKG 400
+ A + D +P+ ++ + + +L++ A
Sbjct: 456 LLQNKA-------------------KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496
Query: 401 LLGTTVTFDDLMGILCKSVLEIERAIKQTQCPADPLQLNKALSIILHLICLLEKVPCT-- 458
L TT L + +E A+ + + A + K LH+ KV
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKE--ASQACMTKKGFTPLHVAAKYGKVRVAEL 554
Query: 459 -LEQDHFKKQTIYRFLKLHPR--GKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILI 515
LE+D HP GKN +PLH+AV N +L + +L+
Sbjct: 555 LLERD------------AHPNAAGKNGLTPLHVAVHHN-------------NLDIVKLLL 589
Query: 516 ECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTASDLLDEKEIAK 575
G + + +PLHIAA N ++ L++ G +A ++ T L ++ A+
Sbjct: 590 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 649
Query: 576 NLIQPINHTTLQCLAAR--VIVNHRIYYKGHIP 606
+ ++ L + + H + +GH+P
Sbjct: 650 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682
Score = 97.8 bits (242), Expect = 3e-20
Identities = 135/573 (23%), Positives = 233/573 (40%), Gaps = 84/573 (14%)
Query: 36 SEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGH 95
++ G TPL MAA+ HL++V+FLLE N + T +G PL A GH
Sbjct: 106 AQSQKGFTPLYMAAQENHLEVVKFLLEN---------GANQNVATEDGFTPLAVALQQGH 156
Query: 96 LKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMI 155
VV L+N+G L A + L+++ + +V ++ G T L I
Sbjct: 157 ENVVAHLINYGTKGK----VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHI 212
Query: 156 SCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKME-KDGYG 214
+ + + +AQ LL +GA VN G T LH + G++ ++++LL A++E K
Sbjct: 213 AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272
Query: 215 MTPLLSASVTGHTNIVDFLTHHAQTSKTERINALELLGATFVDKKRDLLGALKYWKKAMN 274
+TPL A+ GH I + L H + + N L + D + L + ++
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332
Query: 275 MRYSDRTNII-------SKPVPQTLI--MAYDYAKEVNSAEELEGLIADPDEMRMQALLI 325
D + V + L+ A ++ +N L + + +R+ LL+
Sbjct: 333 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH-IACKKNHVRVMELLL 391
Query: 326 R---------ERILGPSHPDTSYYIRYRGAVYADSGNFKRCINLWKYALDMQQSNLDPLS 376
+ E L P H V + G+ NL + SN+ +
Sbjct: 392 KTGASIDAVTESGLTPLH------------VASFMGHLPIVKNLLQRGASPNVSNVKVET 439
Query: 377 PMTASSLLSFAELFSFMLQDRAKGLLGTTVTFDDLMGILCKSVLEIERAIK-QTQCPADP 435
P+ ++ E+ ++LQ++AK DD + C + + +K + A+P
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496
Query: 436 LQLNKALSIILHLICL---LEKVPCTLEQDHFKKQTIYRFLKLHPRGKNNFSPLHLAVDK 492
A LH+ +E V LE++ + K F+PLH+A
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT----------KKGFTPLHVA--- 543
Query: 493 NTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGA 552
K+ ++V +L+E A N + +PLH+A +N+ DI+ LL+ G
Sbjct: 544 ----------AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593
Query: 553 --HFDATN----LHKQTASDLLDEKEIAKNLIQ 579
H A N LH ++ E+A++L+Q
Sbjct: 594 SPHSPAWNGYTPLHIAAKQ---NQVEVARSLLQ 623
Score = 92.8 bits (229), Expect = 8e-19
Identities = 139/608 (22%), Positives = 234/608 (38%), Gaps = 93/608 (15%)
Query: 2 DLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKT---NGATPLLMAARYGHLDMVE 58
D T+ AAR G L K+ + + + + T NG L +A++ GH+ MV
Sbjct: 11 DAATSFLRAARSGNL--------DKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVV 62
Query: 59 FLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNST 118
LL + + + T +G L A+ AG +VV+ L+N+GA+VN + T
Sbjct: 63 ELLHK---------EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFT 113
Query: 119 PLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRK 178
PL A + HLE+VK+L+E+ A+ V+ G T L ++ +GH+ + +L+ G K
Sbjct: 114 PLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT----K 169
Query: 179 SVKGNTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFLTHHA 237
ALH A + +LL + G TPL A+ + N+ L +
Sbjct: 170 GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 229
Query: 238 QTSKTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYD 297
+ N + L S R N+I L++
Sbjct: 230 ASVNFTPQNGITPLHIA-----------------------SRRGNVIM----VRLLLDRG 262
Query: 298 YAKEVNSAEELEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVY-ADSGNFKR 356
E + +EL L R + I E +L P + ++ A G+
Sbjct: 263 AQIETKTKDELTPLHC---AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 319
Query: 357 CIN-LWKYALDMQQSNLDPLSPMTASSLLSFAELFSFMLQDRAKGLLGTTVTFDDLMGIL 415
C+ L +Y ++ LD L+P+ ++ + +L AK F L
Sbjct: 320 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIAC 379
Query: 416 CKSVLEIERAIKQTQCPADPLQLNKALSIILHLICLLEKVPCTLEQDHFKKQTIYRFLKL 475
K+ + + + +T D + ++ LH+ + +P K + R
Sbjct: 380 KKNHVRVMELLLKTGASID--AVTESGLTPLHVASFMGHLPIV-------KNLLQRGASP 430
Query: 476 HPRGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIA 535
+ +PLH+A T V +Y L++ A VN + DD +PLH A
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKY-------------LLQNKAKVNAKAKDDQTPLHCA 477
Query: 536 ALNNHPDIMNLLIKSGA-------------HFDATNLHKQTASDLLDEKEIAKNLIQPIN 582
A H +++ LL+++ A H A H +T LL EKE ++ +
Sbjct: 478 ARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL-EKEASQACMTKKG 536
Query: 583 HTTLQCLA 590
T L A
Sbjct: 537 FTPLHVAA 544
Score = 71.2 bits (173), Expect = 3e-12
Identities = 50/170 (29%), Positives = 81/170 (47%), Gaps = 9/170 (5%)
Query: 38 KTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLK 97
+ + AT L AAR G+LD A + V+ + G L AS GH+K
Sbjct: 9 EADAATSFLRAARSGNLD---------KALDHLRNGVDINTCNQNGLNGLHLASKEGHVK 59
Query: 98 VVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISC 157
+V LL+ + TT +T L A G E+V+ LV + A++ ++ G T L ++
Sbjct: 60 MVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA 119
Query: 158 YKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAK 207
+ H E+ ++LLE GA+ N + G T L + G +++ L+ Y K
Sbjct: 120 QENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK 169
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 115 bits (289), Expect = 9e-26
Identities = 136/595 (22%), Positives = 240/595 (40%), Gaps = 79/595 (13%)
Query: 2 DLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLL 61
D T + AAR+G +R+ LL + + + ++ NG +P+ MAA+ HLD V LL
Sbjct: 271 DELTPLHCAARNGHVRISEILL-----DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLL 325
Query: 62 EQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLR 121
+ D T++ PL A+ GH +V + LL+ GA N+ L TPL
Sbjct: 326 QY---------DAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 376
Query: 122 AACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVK 181
AC H+ +++ L++ A ++ G T L ++ + GH I + LL++GA N +VK
Sbjct: 377 IACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVK 436
Query: 182 GNTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFLTHHAQTS 240
T LH A +G ++ K LL AK+ K TPL A+ GHTN+V L +
Sbjct: 437 VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN---- 492
Query: 241 KTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTN-IISKPVPQTLIMAYDYA 299
NA L T + + + + + + + ++K L +A Y
Sbjct: 493 -----NANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG 547
Query: 300 KEVNSAEELEGLIADPDEMRMQAL----------------LIRERILGPSHPDTSYYIRY 343
K V AE L A P+ L L+ R P P + Y
Sbjct: 548 K-VRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPL 606
Query: 344 RGAVYADSGNFKRCINLWKYALDMQQSNLDPLSPMTASSLLSFAELFSFMLQDRAKGLLG 403
+ A + +L +Y ++ ++P+ ++ AE+ + +L +A G LG
Sbjct: 607 H--IAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664
Query: 404 TTVTFDDLMGILCKSVLEIERAIKQTQCPADPLQLNKALSIILHLICLLEKVPCTLEQDH 463
+ + ++ P + + +++ + P + H
Sbjct: 665 NK-----------SGLTPLHLVAQEGHVPVADVLIKH--GVMVDATTRMGYTPLHV-ASH 710
Query: 464 FKKQTIYRFLKLH-----PRGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECG 518
+ + +FL H + K +SPLH A + T + +L++ G
Sbjct: 711 YGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHT-------------DIVTLLLKNG 757
Query: 519 ADVNVRDSDDNSPLHIAALNNH---PDIMNLLIKSGAHFDATNLHKQTASDLLDE 570
A N SD +PL IA + D++ ++ + ++ H+ + + +DE
Sbjct: 758 ASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDE 812
Score = 102 bits (255), Expect = 8e-22
Identities = 78/236 (33%), Positives = 114/236 (48%), Gaps = 19/236 (8%)
Query: 1 MDLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFL 60
+D T + AA G R+ LL +K +L NG TPL +A + H+ ++E L
Sbjct: 336 LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRAL-----NGFTPLHIACKKNHVRVMELL 390
Query: 61 LEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPL 120
L+ G S+ D T G PL AS GHL +V++LL GAS N + + TPL
Sbjct: 391 LK-------TGASI--DAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441
Query: 121 RAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSV 180
A GH E+ KYL+++KA + + T L + GH + + LLE A+ N +
Sbjct: 442 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 501
Query: 181 KGNTALHDCAESGSLDIMKMLLMYCAK---MEKDGYGMTPLLSASVTGHTNIVDFL 233
G+T LH A G ++ + LL A M K G+ TPL A+ G + + L
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF--TPLHVAAKYGKVRVAELL 555
Score = 101 bits (251), Expect = 2e-21
Identities = 137/633 (21%), Positives = 254/633 (40%), Gaps = 94/633 (14%)
Query: 5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLL--- 61
T ++ AA++ L ++ LL + + + V++ +G TPL +A + GH ++V L+
Sbjct: 113 TPLYMAAQENHLEVVKFLLENGANQNVAT-----EDGFTPLAVALQQGHENVVAHLINYG 167
Query: 62 -----------------EQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLN 104
+ +A++ + N D + G PL A+ +L V Q LLN
Sbjct: 168 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 227
Query: 105 HGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEI 164
GASVN T TPL A G++ +V+ L++ A +E + T L + GH I
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI 287
Query: 165 AQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKMEKDGYG-MTPLLSASV 223
++ LL+ GA + K+ G + +H A+ LD +++LL Y A+++ +TPL A+
Sbjct: 288 SEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAH 347
Query: 224 TGHTNIVDFLTHHAQTSKTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNI 283
GH + L K + N+ L G T + + K + M + +I
Sbjct: 348 CGHHRVAKVLL-----DKGAKPNSRALNGFTPLH-----IACKKNHVRVMELLLKTGASI 397
Query: 284 ISKPVPQTLIMAYDYAKEVNSAEELEGLI---ADPDEMRMQALLIRERILGPSHPDTSYY 340
+ V ++ + A + ++ L+ A P+ ++ H + + Y
Sbjct: 398 DA--VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 455
Query: 341 IRYRGAVYADSGNFKRCINLWKYALDMQQSNLDPLSPMTASSLLSFAELFSFMLQDRAKG 400
+ A + D +P+ ++ + + +L++ A
Sbjct: 456 LLQNKA-------------------KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496
Query: 401 LLGTTVTFDDLMGILCKSVLEIERAIKQTQCPADPLQLNKALSIILHLICLLEKVPCT-- 458
L TT L + +E A+ + + A + K LH+ KV
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKE--ASQACMTKKGFTPLHVAAKYGKVRVAEL 554
Query: 459 -LEQDHFKKQTIYRFLKLHPR--GKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILI 515
LE+D HP GKN +PLH+AV N +L + +L+
Sbjct: 555 LLERD------------AHPNAAGKNGLTPLHVAVHHN-------------NLDIVKLLL 589
Query: 516 ECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTASDLLDEKEIAK 575
G + + +PLHIAA N ++ L++ G +A ++ T L ++ A+
Sbjct: 590 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 649
Query: 576 NLIQPINHTTLQCLAAR--VIVNHRIYYKGHIP 606
+ ++ L + + H + +GH+P
Sbjct: 650 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682
Score = 97.8 bits (242), Expect = 3e-20
Identities = 135/573 (23%), Positives = 233/573 (40%), Gaps = 84/573 (14%)
Query: 36 SEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGH 95
++ G TPL MAA+ HL++V+FLLE N + T +G PL A GH
Sbjct: 106 AQSQKGFTPLYMAAQENHLEVVKFLLEN---------GANQNVATEDGFTPLAVALQQGH 156
Query: 96 LKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMI 155
VV L+N+G L A + L+++ + +V ++ G T L I
Sbjct: 157 ENVVAHLINYGTKGK----VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHI 212
Query: 156 SCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKME-KDGYG 214
+ + + +AQ LL +GA VN G T LH + G++ ++++LL A++E K
Sbjct: 213 AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272
Query: 215 MTPLLSASVTGHTNIVDFLTHHAQTSKTERINALELLGATFVDKKRDLLGALKYWKKAMN 274
+TPL A+ GH I + L H + + N L + D + L + ++
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332
Query: 275 MRYSDRTNII-------SKPVPQTLI--MAYDYAKEVNSAEELEGLIADPDEMRMQALLI 325
D + V + L+ A ++ +N L + + +R+ LL+
Sbjct: 333 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH-IACKKNHVRVMELLL 391
Query: 326 R---------ERILGPSHPDTSYYIRYRGAVYADSGNFKRCINLWKYALDMQQSNLDPLS 376
+ E L P H V + G+ NL + SN+ +
Sbjct: 392 KTGASIDAVTESGLTPLH------------VASFMGHLPIVKNLLQRGASPNVSNVKVET 439
Query: 377 PMTASSLLSFAELFSFMLQDRAKGLLGTTVTFDDLMGILCKSVLEIERAIK-QTQCPADP 435
P+ ++ E+ ++LQ++AK DD + C + + +K + A+P
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496
Query: 436 LQLNKALSIILHLICL---LEKVPCTLEQDHFKKQTIYRFLKLHPRGKNNFSPLHLAVDK 492
A LH+ +E V LE++ + K F+PLH+A
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT----------KKGFTPLHVA--- 543
Query: 493 NTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGA 552
K+ ++V +L+E A N + +PLH+A +N+ DI+ LL+ G
Sbjct: 544 ----------AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593
Query: 553 --HFDATN----LHKQTASDLLDEKEIAKNLIQ 579
H A N LH ++ E+A++L+Q
Sbjct: 594 SPHSPAWNGYTPLHIAAKQ---NQVEVARSLLQ 623
Score = 92.8 bits (229), Expect = 8e-19
Identities = 139/608 (22%), Positives = 234/608 (38%), Gaps = 93/608 (15%)
Query: 2 DLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKT---NGATPLLMAARYGHLDMVE 58
D T+ AAR G L K+ + + + + T NG L +A++ GH+ MV
Sbjct: 11 DAATSFLRAARSGNL--------DKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVV 62
Query: 59 FLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNST 118
LL + + + T +G L A+ AG +VV+ L+N+GA+VN + T
Sbjct: 63 ELLHK---------EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFT 113
Query: 119 PLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRK 178
PL A + HLE+VK+L+E+ A+ V+ G T L ++ +GH+ + +L+ G K
Sbjct: 114 PLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT----K 169
Query: 179 SVKGNTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFLTHHA 237
ALH A + +LL + G TPL A+ + N+ L +
Sbjct: 170 GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 229
Query: 238 QTSKTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYD 297
+ N + L S R N+I L++
Sbjct: 230 ASVNFTPQNGITPLHIA-----------------------SRRGNVIM----VRLLLDRG 262
Query: 298 YAKEVNSAEELEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVY-ADSGNFKR 356
E + +EL L R + I E +L P + ++ A G+
Sbjct: 263 AQIETKTKDELTPLHC---AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 319
Query: 357 CIN-LWKYALDMQQSNLDPLSPMTASSLLSFAELFSFMLQDRAKGLLGTTVTFDDLMGIL 415
C+ L +Y ++ LD L+P+ ++ + +L AK F L
Sbjct: 320 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIAC 379
Query: 416 CKSVLEIERAIKQTQCPADPLQLNKALSIILHLICLLEKVPCTLEQDHFKKQTIYRFLKL 475
K+ + + + +T D + ++ LH+ + +P K + R
Sbjct: 380 KKNHVRVMELLLKTGASID--AVTESGLTPLHVASFMGHLPIV-------KNLLQRGASP 430
Query: 476 HPRGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIA 535
+ +PLH+A T V +Y L++ A VN + DD +PLH A
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKY-------------LLQNKAKVNAKAKDDQTPLHCA 477
Query: 536 ALNNHPDIMNLLIKSGA-------------HFDATNLHKQTASDLLDEKEIAKNLIQPIN 582
A H +++ LL+++ A H A H +T LL EKE ++ +
Sbjct: 478 ARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL-EKEASQACMTKKG 536
Query: 583 HTTLQCLA 590
T L A
Sbjct: 537 FTPLHVAA 544
Score = 71.2 bits (173), Expect = 3e-12
Identities = 50/170 (29%), Positives = 81/170 (47%), Gaps = 9/170 (5%)
Query: 38 KTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLK 97
+ + AT L AAR G+LD A + V+ + G L AS GH+K
Sbjct: 9 EADAATSFLRAARSGNLD---------KALDHLRNGVDINTCNQNGLNGLHLASKEGHVK 59
Query: 98 VVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISC 157
+V LL+ + TT +T L A G E+V+ LV + A++ ++ G T L ++
Sbjct: 60 MVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA 119
Query: 158 YKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAK 207
+ H E+ ++LLE GA+ N + G T L + G +++ L+ Y K
Sbjct: 120 QENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK 169
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 110 bits (275), Expect = 4e-24
Identities = 74/242 (30%), Positives = 127/242 (52%), Gaps = 15/242 (6%)
Query: 5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQC 64
T + AA G + + T LL + + ++ NG TPL +A++ G+ +MV+ LL++
Sbjct: 214 TPLHIAAHYGNVNVATLLLNRGAAVDFTA-----RNGITPLHVASKRGNTNMVKLLLDR- 267
Query: 65 SASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAAC 124
GG + D +T +G PL A+ +GH +VV+ LL GA + T +PL A
Sbjct: 268 ------GGQI--DAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAA 319
Query: 125 FDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNT 184
H+E VK+L++HKA ++ T L ++ + GH + + LL+K A+ N +++ G T
Sbjct: 320 QGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFT 379
Query: 185 ALHDCAESGSLDIMKMLLMYCAKMEK-DGYGMTPLLSASVTGHTNIVDFLTHHAQTSKTE 243
LH + + +M++L+ Y A ++ G+TP+ A+ GH NIV L + +
Sbjct: 380 PLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVT 439
Query: 244 RI 245
I
Sbjct: 440 NI 441
Score = 109 bits (272), Expect = 9e-24
Identities = 138/572 (24%), Positives = 231/572 (40%), Gaps = 80/572 (13%)
Query: 6 AVFNAARDGKLRLLTKLLASKSKEEVSS--LISEKT-NGATPLLMAARYGHLDMVEFLLE 62
A+ AAR + LL + +V S +++ T +G TPL +AA YG++++ LL
Sbjct: 174 ALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN 233
Query: 63 QCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRA 122
+ G +V+F G PL AS G+ +V+ LL+ G ++ T TPL
Sbjct: 234 R-------GAAVDFTARN--GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHC 284
Query: 123 ACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKG 182
A GH ++V+ L+E A L ++G + L ++ H E ++LL+ A V+ ++
Sbjct: 285 AARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDY 344
Query: 183 NTALHDCAESGSLDIMKMLLMYCAKMEKDGY-GMTPLLSASVTGHTNIVDFLTHHAQTSK 241
TALH A G + K+LL A G TPL A +++ L + + +
Sbjct: 345 LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQ 404
Query: 242 TERINALELLG-ATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAK 300
+ L + A F+ +L L+ N D TNI + A A
Sbjct: 405 AITESGLTPIHVAAFMGHLNIVLLLLQ------NGASPDVTNIRGET-------ALHMAA 451
Query: 301 EVNSAEELEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINL 360
E + L+ + + +A RE T +I R G + L
Sbjct: 452 RAGQVEVVRCLLRNGALVDARA---REE-------QTPLHIASR------LGKTEIVQLL 495
Query: 361 WKYALDMQQSNLDPLSPMTASSLLSFAELFSFMLQDRAKGLLGTTVTFDDLMGILCKSVL 420
++ + + +P+ S+ ++ S +L+ A L T F L L
Sbjct: 496 LQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSL 555
Query: 421 EIERAIKQTQCPADPLQLNKALSIILHLICLLEKVPCTLEQDHFKKQTIYRFL-----KL 475
++ + + Q + AD N LH+ H+ Q + L
Sbjct: 556 DVAKLLLQRRAAADSAGKNGLTP--LHVAA------------HYDNQKVALLLLEKGASP 601
Query: 476 HPRGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIA 535
H KN ++PLH+A KN +Q+ + L+ GA+ N+ +PLH+A
Sbjct: 602 HATAKNGYTPLHIAAKKN-------------QMQIASTLLNYGAETNIVTKQGVTPLHLA 648
Query: 536 ALNNHPDIMNLLIKSGAHFDATNLHKQTASDL 567
+ H D++ LL+ GA N+H T S L
Sbjct: 649 SQEGHTDMVTLLLDKGA-----NIHMSTKSGL 675
Score = 102 bits (254), Expect = 1e-21
Identities = 70/233 (30%), Positives = 117/233 (50%), Gaps = 15/233 (6%)
Query: 5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQC 64
T + AAR G +++ LL E + L++ NG +PL MAA+ H++ V+ LL+
Sbjct: 280 TPLHCAARSGHDQVVELLL-----ERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH- 333
Query: 65 SASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAAC 124
D T++ L A+ GH +V + LL+ A+ N L TPL AC
Sbjct: 334 --------KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIAC 385
Query: 125 FDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNT 184
+++++ LV++ A ++ G T + ++ + GH I LL+ GA + +++G T
Sbjct: 386 KKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGET 445
Query: 185 ALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFLTHH 236
ALH A +G +++++ LL A ++ + TPL AS G T IV L H
Sbjct: 446 ALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 498
Score = 100 bits (249), Expect = 4e-21
Identities = 72/239 (30%), Positives = 119/239 (49%), Gaps = 20/239 (8%)
Query: 4 KTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEK--------TNGATPLLMAARYGHLD 55
+ A +A ++G L + A ++V+ L+ EK NG TPL +AA+ +
Sbjct: 565 RAAADSAGKNGLTPL--HVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQ 622
Query: 56 MVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLT 115
+ LL G N T +G PL AS GH +V LL+ GA+++ +T +
Sbjct: 623 IASTLLNY-------GAETNI--VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKS 673
Query: 116 NSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADV 175
T L A + + + L +H AD + + G+T L+++C+ G+ ++ +LL++GA+V
Sbjct: 674 GLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANV 733
Query: 176 NRKSVKGNTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFL 233
N K+ G T LH A+ G I+ +LL + AK G T L A G+ ++VD L
Sbjct: 734 NAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 792
Score = 99.8 bits (247), Expect = 7e-21
Identities = 84/325 (25%), Positives = 147/325 (45%), Gaps = 36/325 (11%)
Query: 5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQC 64
T + +AR+G++ + + LL + + SL ++K G TPL +AA+YG LD+ + LL++
Sbjct: 511 TPLHISAREGQVDVASVLLEAGAAH---SLATKK--GFTPLHVAAKYGSLDVAKLLLQRR 565
Query: 65 SASIEVGGS--------VNFDGETI----------------EGAPPLWAASAAGHLKVVQ 100
+A+ G + ++D + + G PL A+ +++
Sbjct: 566 AAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIAS 625
Query: 101 SLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKG 160
+LLN+GA N T TPL A +GH ++V L++ A++ +S + G T L ++ +
Sbjct: 626 TLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQED 685
Query: 161 HKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLL 219
+A L + GAD + + G T L G++ ++ LL A + K G TPL
Sbjct: 686 KVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLH 745
Query: 220 SASVTGHTNIVDFLTHHAQTSKTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSD 279
A+ GHT+I++ L H N L + K+ + + K +
Sbjct: 746 QAAQQGHTHIINVLLQHGAKPNATTANGNTALA---IAKRLGYISVVDTLKVVTEEVTTT 802
Query: 280 RTNIISK---PVPQTLIMAYDYAKE 301
T I K VP+T+ D + E
Sbjct: 803 TTTITEKHKLNVPETMTEVLDVSDE 827
Score = 94.7 bits (234), Expect = 2e-19
Identities = 143/616 (23%), Positives = 247/616 (40%), Gaps = 115/616 (18%)
Query: 2 DLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLL 61
D + AAR G L + + L K ++++ NG L +AA+ GH+ +V+ LL
Sbjct: 9 DSNASFLRAARAGNLDKVVEYL--KGGIDINTC---NQNGLNALHLAAKEGHVGLVQELL 63
Query: 62 EQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLR 121
+ G SV D T +G L AS AG +VV+ L+ GA++N + TPL
Sbjct: 64 GR-------GSSV--DSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLY 114
Query: 122 AACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEK---------- 171
A + H+++VKYL+E+ A+ + G T L ++ +GH + LLE
Sbjct: 115 MAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPA 174
Query: 172 ---------------------GAD------VNRKSVKGNTALHDCAESGSLDIMKMLLMY 204
AD VNR + G T LH A G++++ +LL
Sbjct: 175 LHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNR 234
Query: 205 CAKMEKDG-YGMTPLLSASVTGHTNIV---------------DFLTHHAQTSKTERINAL 248
A ++ G+TPL AS G+TN+V D LT +++ +
Sbjct: 235 GAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVV 294
Query: 249 ELL---GATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAKEVNSA 305
ELL GA + + ++ L L + ++ PV + DY ++ A
Sbjct: 295 ELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTL---DYLTALHVA 351
Query: 306 EELEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINLW-KYA 364
A R+ LL+ +R ++P+ + A N + + L KY
Sbjct: 352 -------AHCGHYRVTKLLLDKR----ANPNARALNGFTPLHIACKKNRIKVMELLVKYG 400
Query: 365 LDMQQSNLDPLSPMTASSLLSFAELFSFMLQDRAKGLLGTTVTFDDLMGILCKSVLEIER 424
+Q L+P+ ++ + + +LQ+ A D+ I ++ L +
Sbjct: 401 ASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGAS---------PDVTNIRGETALHMAA 451
Query: 425 AIKQTQCPADPLQLNKALSIILHLICLLEKVPCTLEQDHFKKQTIYRFLK--LHPRG--K 480
Q + L+ N AL + E+ P + K + + L+ HP
Sbjct: 452 RAGQVEVVRCLLR-NGAL---VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATT 507
Query: 481 NNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNH 540
N ++PLH++ + + V ++L+E GA ++ +PLH+AA
Sbjct: 508 NGYTPLHISAREG-------------QVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGS 554
Query: 541 PDIMNLLIKSGAHFDA 556
D+ LL++ A D+
Sbjct: 555 LDVAKLLLQRRAAADS 570
Score = 87.4 bits (215), Expect = 3e-17
Identities = 69/234 (29%), Positives = 111/234 (47%), Gaps = 15/234 (6%)
Query: 4 KTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQ 63
+T + A+R GK ++ LL + + ++ TNG TPL ++AR G +D+ LLE
Sbjct: 477 QTPLHIASRLGKTEIVQLLLQHMAHPDAAT-----TNGYTPLHISAREGQVDVASVLLEA 531
Query: 64 CSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAA 123
+A T +G PL A+ G L V + LL A+ ++ TPL A
Sbjct: 532 GAAHSLA---------TKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVA 582
Query: 124 CFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGN 183
+ ++ L+E A + ++G+T L I+ K +IA LL GA+ N + +G
Sbjct: 583 AHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV 642
Query: 184 TALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFLTHH 236
T LH ++ G D++ +LL A + G+T L A+ N+ D LT H
Sbjct: 643 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKH 696
Score = 77.8 bits (190), Expect = 3e-14
Identities = 50/166 (30%), Positives = 84/166 (50%), Gaps = 9/166 (5%)
Query: 37 EKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHL 96
+K++ L AAR G+LD V L+ G ++ + G L A+ GH+
Sbjct: 6 QKSDSNASFLRAARAGNLDKVVEYLK---------GGIDINTCNQNGLNALHLAAKEGHV 56
Query: 97 KVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMIS 156
+VQ LL G+SV++ T +T L A G E+VK LV+ A++ +++G T L ++
Sbjct: 57 GLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMA 116
Query: 157 CYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLL 202
+ H ++ +YLLE GA+ + + G T L + G + +LL
Sbjct: 117 AQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 162
Score = 45.8 bits (107), Expect = 1e-04
Identities = 30/110 (27%), Positives = 54/110 (49%), Gaps = 20/110 (18%)
Query: 475 LHPRGKNNFSPLHLAVDKNT-----------------TCVGRYPV---CKFPSLQVTAIL 514
+H K+ + LHLA ++ T +G P+ C + ++++ L
Sbjct: 667 IHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFL 726
Query: 515 IECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTA 564
++ GA+VN + + +PLH AA H I+N+L++ GA +AT + TA
Sbjct: 727 LKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTA 776
Score = 30.8 bits (68), Expect = 3.8
Identities = 27/99 (27%), Positives = 43/99 (43%), Gaps = 7/99 (7%)
Query: 459 LEQDHFKKQTIYRFLKLHPRGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECG 518
L+Q H Q + L+ +GK LH+A K+ T + + V + ++
Sbjct: 150 LQQGH--NQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMM--- 204
Query: 519 ADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDAT 557
VN +PLHIAA + ++ LL+ GA D T
Sbjct: 205 --VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT 241
Score = 30.4 bits (67), Expect = 5.0
Identities = 17/65 (26%), Positives = 32/65 (49%), Gaps = 3/65 (4%)
Query: 518 GADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTA---SDLLDEKEIA 574
G D+N + + + LH+AA H ++ L+ G+ D+ TA + L + E+
Sbjct: 33 GIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVV 92
Query: 575 KNLIQ 579
K L++
Sbjct: 93 KVLVK 97
Score = 30.0 bits (66), Expect = 6.6
Identities = 28/108 (25%), Positives = 49/108 (45%), Gaps = 22/108 (20%)
Query: 478 RGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAAL 537
R + +PLH+A T ++ +L++ A + ++ +PLHI+A
Sbjct: 472 RAREEQTPLHIASRLGKT-------------EIVQLLLQHMAHPDAATTNGYTPLHISAR 518
Query: 538 NNHPDIMNLLIKSG-AHFDATN-----LHKQTASDLLDEKEIAKNLIQ 579
D+ ++L+++G AH AT LH LD +AK L+Q
Sbjct: 519 EGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLD---VAKLLLQ 563
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 110 bits (275), Expect = 4e-24
Identities = 74/242 (30%), Positives = 127/242 (52%), Gaps = 15/242 (6%)
Query: 5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQC 64
T + AA G + + T LL + + ++ NG TPL +A++ G+ +MV+ LL++
Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTA-----RNGITPLHVASKRGNTNMVKLLLDR- 288
Query: 65 SASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAAC 124
GG + D +T +G PL A+ +GH +VV+ LL GA + T +PL A
Sbjct: 289 ------GGQI--DAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAA 340
Query: 125 FDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNT 184
H+E VK+L++HKA ++ T L ++ + GH + + LL+K A+ N +++ G T
Sbjct: 341 QGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFT 400
Query: 185 ALHDCAESGSLDIMKMLLMYCAKMEK-DGYGMTPLLSASVTGHTNIVDFLTHHAQTSKTE 243
LH + + +M++L+ Y A ++ G+TP+ A+ GH NIV L + +
Sbjct: 401 PLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVT 460
Query: 244 RI 245
I
Sbjct: 461 NI 462
Score = 109 bits (272), Expect = 9e-24
Identities = 138/572 (24%), Positives = 231/572 (40%), Gaps = 80/572 (13%)
Query: 6 AVFNAARDGKLRLLTKLLASKSKEEVSS--LISEKT-NGATPLLMAARYGHLDMVEFLLE 62
A+ AAR + LL + +V S +++ T +G TPL +AA YG++++ LL
Sbjct: 195 ALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN 254
Query: 63 QCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRA 122
+ G +V+F G PL AS G+ +V+ LL+ G ++ T TPL
Sbjct: 255 R-------GAAVDFTARN--GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHC 305
Query: 123 ACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKG 182
A GH ++V+ L+E A L ++G + L ++ H E ++LL+ A V+ ++
Sbjct: 306 AARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDY 365
Query: 183 NTALHDCAESGSLDIMKMLLMYCAKMEKDGY-GMTPLLSASVTGHTNIVDFLTHHAQTSK 241
TALH A G + K+LL A G TPL A +++ L + + +
Sbjct: 366 LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQ 425
Query: 242 TERINALELLG-ATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAK 300
+ L + A F+ +L L+ N D TNI + A A
Sbjct: 426 AITESGLTPIHVAAFMGHLNIVLLLLQ------NGASPDVTNIRGET-------ALHMAA 472
Query: 301 EVNSAEELEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINL 360
E + L+ + + +A RE T +I R G + L
Sbjct: 473 RAGQVEVVRCLLRNGALVDARA---REE-------QTPLHIASR------LGKTEIVQLL 516
Query: 361 WKYALDMQQSNLDPLSPMTASSLLSFAELFSFMLQDRAKGLLGTTVTFDDLMGILCKSVL 420
++ + + +P+ S+ ++ S +L+ A L T F L L
Sbjct: 517 LQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSL 576
Query: 421 EIERAIKQTQCPADPLQLNKALSIILHLICLLEKVPCTLEQDHFKKQTIYRFL-----KL 475
++ + + Q + AD N LH+ H+ Q + L
Sbjct: 577 DVAKLLLQRRAAADSAGKNGLTP--LHVAA------------HYDNQKVALLLLEKGASP 622
Query: 476 HPRGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIA 535
H KN ++PLH+A KN +Q+ + L+ GA+ N+ +PLH+A
Sbjct: 623 HATAKNGYTPLHIAAKKN-------------QMQIASTLLNYGAETNIVTKQGVTPLHLA 669
Query: 536 ALNNHPDIMNLLIKSGAHFDATNLHKQTASDL 567
+ H D++ LL+ GA N+H T S L
Sbjct: 670 SQEGHTDMVTLLLDKGA-----NIHMSTKSGL 696
Score = 102 bits (254), Expect = 1e-21
Identities = 70/233 (30%), Positives = 117/233 (50%), Gaps = 15/233 (6%)
Query: 5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQC 64
T + AAR G +++ LL E + L++ NG +PL MAA+ H++ V+ LL+
Sbjct: 301 TPLHCAARSGHDQVVELLL-----ERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH- 354
Query: 65 SASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAAC 124
D T++ L A+ GH +V + LL+ A+ N L TPL AC
Sbjct: 355 --------KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIAC 406
Query: 125 FDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNT 184
+++++ LV++ A ++ G T + ++ + GH I LL+ GA + +++G T
Sbjct: 407 KKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGET 466
Query: 185 ALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFLTHH 236
ALH A +G +++++ LL A ++ + TPL AS G T IV L H
Sbjct: 467 ALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 519
Score = 100 bits (249), Expect = 4e-21
Identities = 72/239 (30%), Positives = 119/239 (49%), Gaps = 20/239 (8%)
Query: 4 KTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEK--------TNGATPLLMAARYGHLD 55
+ A +A ++G L + A ++V+ L+ EK NG TPL +AA+ +
Sbjct: 586 RAAADSAGKNGLTPL--HVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQ 643
Query: 56 MVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLT 115
+ LL G N T +G PL AS GH +V LL+ GA+++ +T +
Sbjct: 644 IASTLLNY-------GAETNI--VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKS 694
Query: 116 NSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADV 175
T L A + + + L +H AD + + G+T L+++C+ G+ ++ +LL++GA+V
Sbjct: 695 GLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANV 754
Query: 176 NRKSVKGNTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFL 233
N K+ G T LH A+ G I+ +LL + AK G T L A G+ ++VD L
Sbjct: 755 NAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
Score = 99.8 bits (247), Expect = 7e-21
Identities = 84/325 (25%), Positives = 147/325 (45%), Gaps = 36/325 (11%)
Query: 5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQC 64
T + +AR+G++ + + LL + + SL ++K G TPL +AA+YG LD+ + LL++
Sbjct: 532 TPLHISAREGQVDVASVLLEAGAAH---SLATKK--GFTPLHVAAKYGSLDVAKLLLQRR 586
Query: 65 SASIEVGGS--------VNFDGETI----------------EGAPPLWAASAAGHLKVVQ 100
+A+ G + ++D + + G PL A+ +++
Sbjct: 587 AAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIAS 646
Query: 101 SLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKG 160
+LLN+GA N T TPL A +GH ++V L++ A++ +S + G T L ++ +
Sbjct: 647 TLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQED 706
Query: 161 HKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLL 219
+A L + GAD + + G T L G++ ++ LL A + K G TPL
Sbjct: 707 KVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLH 766
Query: 220 SASVTGHTNIVDFLTHHAQTSKTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSD 279
A+ GHT+I++ L H N L + K+ + + K +
Sbjct: 767 QAAQQGHTHIINVLLQHGAKPNATTANGNTALA---IAKRLGYISVVDTLKVVTEEVTTT 823
Query: 280 RTNIISK---PVPQTLIMAYDYAKE 301
T I K VP+T+ D + E
Sbjct: 824 TTTITEKHKLNVPETMTEVLDVSDE 848
Score = 94.7 bits (234), Expect = 2e-19
Identities = 143/616 (23%), Positives = 247/616 (40%), Gaps = 115/616 (18%)
Query: 2 DLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLL 61
D + AAR G L + + L K ++++ NG L +AA+ GH+ +V+ LL
Sbjct: 30 DSNASFLRAARAGNLDKVVEYL--KGGIDINTC---NQNGLNALHLAAKEGHVGLVQELL 84
Query: 62 EQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLR 121
+ G SV D T +G L AS AG +VV+ L+ GA++N + TPL
Sbjct: 85 GR-------GSSV--DSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLY 135
Query: 122 AACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEK---------- 171
A + H+++VKYL+E+ A+ + G T L ++ +GH + LLE
Sbjct: 136 MAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPA 195
Query: 172 ---------------------GAD------VNRKSVKGNTALHDCAESGSLDIMKMLLMY 204
AD VNR + G T LH A G++++ +LL
Sbjct: 196 LHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNR 255
Query: 205 CAKMEKDG-YGMTPLLSASVTGHTNIV---------------DFLTHHAQTSKTERINAL 248
A ++ G+TPL AS G+TN+V D LT +++ +
Sbjct: 256 GAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVV 315
Query: 249 ELL---GATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAKEVNSA 305
ELL GA + + ++ L L + ++ PV + DY ++ A
Sbjct: 316 ELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTL---DYLTALHVA 372
Query: 306 EELEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINLW-KYA 364
A R+ LL+ +R ++P+ + A N + + L KY
Sbjct: 373 -------AHCGHYRVTKLLLDKR----ANPNARALNGFTPLHIACKKNRIKVMELLVKYG 421
Query: 365 LDMQQSNLDPLSPMTASSLLSFAELFSFMLQDRAKGLLGTTVTFDDLMGILCKSVLEIER 424
+Q L+P+ ++ + + +LQ+ A D+ I ++ L +
Sbjct: 422 ASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGAS---------PDVTNIRGETALHMAA 472
Query: 425 AIKQTQCPADPLQLNKALSIILHLICLLEKVPCTLEQDHFKKQTIYRFLK--LHPRG--K 480
Q + L+ N AL + E+ P + K + + L+ HP
Sbjct: 473 RAGQVEVVRCLLR-NGAL---VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATT 528
Query: 481 NNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNH 540
N ++PLH++ + + V ++L+E GA ++ +PLH+AA
Sbjct: 529 NGYTPLHISAREG-------------QVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGS 575
Query: 541 PDIMNLLIKSGAHFDA 556
D+ LL++ A D+
Sbjct: 576 LDVAKLLLQRRAAADS 591
Score = 87.4 bits (215), Expect = 3e-17
Identities = 69/234 (29%), Positives = 111/234 (47%), Gaps = 15/234 (6%)
Query: 4 KTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQ 63
+T + A+R GK ++ LL + + ++ TNG TPL ++AR G +D+ LLE
Sbjct: 498 QTPLHIASRLGKTEIVQLLLQHMAHPDAAT-----TNGYTPLHISAREGQVDVASVLLEA 552
Query: 64 CSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAA 123
+A T +G PL A+ G L V + LL A+ ++ TPL A
Sbjct: 553 GAAHSLA---------TKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVA 603
Query: 124 CFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGN 183
+ ++ L+E A + ++G+T L I+ K +IA LL GA+ N + +G
Sbjct: 604 AHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV 663
Query: 184 TALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFLTHH 236
T LH ++ G D++ +LL A + G+T L A+ N+ D LT H
Sbjct: 664 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKH 717
Score = 77.4 bits (189), Expect = 4e-14
Identities = 50/166 (30%), Positives = 84/166 (50%), Gaps = 9/166 (5%)
Query: 37 EKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHL 96
+K++ L AAR G+LD V L+ G ++ + G L A+ GH+
Sbjct: 27 KKSDSNASFLRAARAGNLDKVVEYLK---------GGIDINTCNQNGLNALHLAAKEGHV 77
Query: 97 KVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMIS 156
+VQ LL G+SV++ T +T L A G E+VK LV+ A++ +++G T L ++
Sbjct: 78 GLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMA 137
Query: 157 CYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLL 202
+ H ++ +YLLE GA+ + + G T L + G + +LL
Sbjct: 138 AQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183
Score = 45.8 bits (107), Expect = 1e-04
Identities = 30/110 (27%), Positives = 54/110 (49%), Gaps = 20/110 (18%)
Query: 475 LHPRGKNNFSPLHLAVDKNT-----------------TCVGRYPV---CKFPSLQVTAIL 514
+H K+ + LHLA ++ T +G P+ C + ++++ L
Sbjct: 688 IHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFL 747
Query: 515 IECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTA 564
++ GA+VN + + +PLH AA H I+N+L++ GA +AT + TA
Sbjct: 748 LKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTA 797
Score = 30.8 bits (68), Expect = 3.8
Identities = 27/99 (27%), Positives = 43/99 (43%), Gaps = 7/99 (7%)
Query: 459 LEQDHFKKQTIYRFLKLHPRGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECG 518
L+Q H Q + L+ +GK LH+A K+ T + + V + ++
Sbjct: 171 LQQGH--NQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMM--- 225
Query: 519 ADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDAT 557
VN +PLHIAA + ++ LL+ GA D T
Sbjct: 226 --VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT 262
Score = 30.4 bits (67), Expect = 5.0
Identities = 17/65 (26%), Positives = 32/65 (49%), Gaps = 3/65 (4%)
Query: 518 GADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTA---SDLLDEKEIA 574
G D+N + + + LH+AA H ++ L+ G+ D+ TA + L + E+
Sbjct: 54 GIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVV 113
Query: 575 KNLIQ 579
K L++
Sbjct: 114 KVLVK 118
Score = 30.0 bits (66), Expect = 6.6
Identities = 28/108 (25%), Positives = 49/108 (45%), Gaps = 22/108 (20%)
Query: 478 RGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAAL 537
R + +PLH+A T ++ +L++ A + ++ +PLHI+A
Sbjct: 493 RAREEQTPLHIASRLGKT-------------EIVQLLLQHMAHPDAATTNGYTPLHISAR 539
Query: 538 NNHPDIMNLLIKSG-AHFDATN-----LHKQTASDLLDEKEIAKNLIQ 579
D+ ++L+++G AH AT LH LD +AK L+Q
Sbjct: 540 EGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLD---VAKLLLQ 584
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 110 bits (275), Expect = 4e-24
Identities = 74/242 (30%), Positives = 127/242 (52%), Gaps = 15/242 (6%)
Query: 5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQC 64
T + AA G + + T LL + + ++ NG TPL +A++ G+ +MV+ LL++
Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTA-----RNGITPLHVASKRGNTNMVKLLLDR- 288
Query: 65 SASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAAC 124
GG + D +T +G PL A+ +GH +VV+ LL GA + T +PL A
Sbjct: 289 ------GGQI--DAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAA 340
Query: 125 FDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNT 184
H+E VK+L++HKA ++ T L ++ + GH + + LL+K A+ N +++ G T
Sbjct: 341 QGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFT 400
Query: 185 ALHDCAESGSLDIMKMLLMYCAKMEK-DGYGMTPLLSASVTGHTNIVDFLTHHAQTSKTE 243
LH + + +M++L+ Y A ++ G+TP+ A+ GH NIV L + +
Sbjct: 401 PLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVT 460
Query: 244 RI 245
I
Sbjct: 461 NI 462
Score = 109 bits (272), Expect = 9e-24
Identities = 138/572 (24%), Positives = 231/572 (40%), Gaps = 80/572 (13%)
Query: 6 AVFNAARDGKLRLLTKLLASKSKEEVSS--LISEKT-NGATPLLMAARYGHLDMVEFLLE 62
A+ AAR + LL + +V S +++ T +G TPL +AA YG++++ LL
Sbjct: 195 ALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN 254
Query: 63 QCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRA 122
+ G +V+F G PL AS G+ +V+ LL+ G ++ T TPL
Sbjct: 255 R-------GAAVDFTARN--GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHC 305
Query: 123 ACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKG 182
A GH ++V+ L+E A L ++G + L ++ H E ++LL+ A V+ ++
Sbjct: 306 AARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDY 365
Query: 183 NTALHDCAESGSLDIMKMLLMYCAKMEKDGY-GMTPLLSASVTGHTNIVDFLTHHAQTSK 241
TALH A G + K+LL A G TPL A +++ L + + +
Sbjct: 366 LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQ 425
Query: 242 TERINALELLG-ATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAK 300
+ L + A F+ +L L+ N D TNI + A A
Sbjct: 426 AITESGLTPIHVAAFMGHLNIVLLLLQ------NGASPDVTNIRGET-------ALHMAA 472
Query: 301 EVNSAEELEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINL 360
E + L+ + + +A RE T +I R G + L
Sbjct: 473 RAGQVEVVRCLLRNGALVDARA---REE-------QTPLHIASR------LGKTEIVQLL 516
Query: 361 WKYALDMQQSNLDPLSPMTASSLLSFAELFSFMLQDRAKGLLGTTVTFDDLMGILCKSVL 420
++ + + +P+ S+ ++ S +L+ A L T F L L
Sbjct: 517 LQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSL 576
Query: 421 EIERAIKQTQCPADPLQLNKALSIILHLICLLEKVPCTLEQDHFKKQTIYRFL-----KL 475
++ + + Q + AD N LH+ H+ Q + L
Sbjct: 577 DVAKLLLQRRAAADSAGKNGLTP--LHVAA------------HYDNQKVALLLLEKGASP 622
Query: 476 HPRGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIA 535
H KN ++PLH+A KN +Q+ + L+ GA+ N+ +PLH+A
Sbjct: 623 HATAKNGYTPLHIAAKKN-------------QMQIASTLLNYGAETNIVTKQGVTPLHLA 669
Query: 536 ALNNHPDIMNLLIKSGAHFDATNLHKQTASDL 567
+ H D++ LL+ GA N+H T S L
Sbjct: 670 SQEGHTDMVTLLLDKGA-----NIHMSTKSGL 696
Score = 102 bits (254), Expect = 1e-21
Identities = 70/233 (30%), Positives = 117/233 (50%), Gaps = 15/233 (6%)
Query: 5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQC 64
T + AAR G +++ LL E + L++ NG +PL MAA+ H++ V+ LL+
Sbjct: 301 TPLHCAARSGHDQVVELLL-----ERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH- 354
Query: 65 SASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAAC 124
D T++ L A+ GH +V + LL+ A+ N L TPL AC
Sbjct: 355 --------KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIAC 406
Query: 125 FDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNT 184
+++++ LV++ A ++ G T + ++ + GH I LL+ GA + +++G T
Sbjct: 407 KKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGET 466
Query: 185 ALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFLTHH 236
ALH A +G +++++ LL A ++ + TPL AS G T IV L H
Sbjct: 467 ALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 519
Score = 100 bits (249), Expect = 4e-21
Identities = 72/239 (30%), Positives = 119/239 (49%), Gaps = 20/239 (8%)
Query: 4 KTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEK--------TNGATPLLMAARYGHLD 55
+ A +A ++G L + A ++V+ L+ EK NG TPL +AA+ +
Sbjct: 586 RAAADSAGKNGLTPL--HVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQ 643
Query: 56 MVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLT 115
+ LL G N T +G PL AS GH +V LL+ GA+++ +T +
Sbjct: 644 IASTLLNY-------GAETNI--VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKS 694
Query: 116 NSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADV 175
T L A + + + L +H AD + + G+T L+++C+ G+ ++ +LL++GA+V
Sbjct: 695 GLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANV 754
Query: 176 NRKSVKGNTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFL 233
N K+ G T LH A+ G I+ +LL + AK G T L A G+ ++VD L
Sbjct: 755 NAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
Score = 99.8 bits (247), Expect = 7e-21
Identities = 84/325 (25%), Positives = 147/325 (45%), Gaps = 36/325 (11%)
Query: 5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQC 64
T + +AR+G++ + + LL + + SL ++K G TPL +AA+YG LD+ + LL++
Sbjct: 532 TPLHISAREGQVDVASVLLEAGAAH---SLATKK--GFTPLHVAAKYGSLDVAKLLLQRR 586
Query: 65 SASIEVGGS--------VNFDGETI----------------EGAPPLWAASAAGHLKVVQ 100
+A+ G + ++D + + G PL A+ +++
Sbjct: 587 AAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIAS 646
Query: 101 SLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKG 160
+LLN+GA N T TPL A +GH ++V L++ A++ +S + G T L ++ +
Sbjct: 647 TLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQED 706
Query: 161 HKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLL 219
+A L + GAD + + G T L G++ ++ LL A + K G TPL
Sbjct: 707 KVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLH 766
Query: 220 SASVTGHTNIVDFLTHHAQTSKTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSD 279
A+ GHT+I++ L H N L + K+ + + K +
Sbjct: 767 QAAQQGHTHIINVLLQHGAKPNATTANGNTALA---IAKRLGYISVVDTLKVVTEEVTTT 823
Query: 280 RTNIISK---PVPQTLIMAYDYAKE 301
T I K VP+T+ D + E
Sbjct: 824 TTTITEKHKLNVPETMTEVLDVSDE 848
Score = 94.7 bits (234), Expect = 2e-19
Identities = 143/616 (23%), Positives = 247/616 (40%), Gaps = 115/616 (18%)
Query: 2 DLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLL 61
D + AAR G L + + L K ++++ NG L +AA+ GH+ +V+ LL
Sbjct: 30 DSNASFLRAARAGNLDKVVEYL--KGGIDINTC---NQNGLNALHLAAKEGHVGLVQELL 84
Query: 62 EQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLR 121
+ G SV D T +G L AS AG +VV+ L+ GA++N + TPL
Sbjct: 85 GR-------GSSV--DSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLY 135
Query: 122 AACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEK---------- 171
A + H+++VKYL+E+ A+ + G T L ++ +GH + LLE
Sbjct: 136 MAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPA 195
Query: 172 ---------------------GAD------VNRKSVKGNTALHDCAESGSLDIMKMLLMY 204
AD VNR + G T LH A G++++ +LL
Sbjct: 196 LHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNR 255
Query: 205 CAKMEKDG-YGMTPLLSASVTGHTNIV---------------DFLTHHAQTSKTERINAL 248
A ++ G+TPL AS G+TN+V D LT +++ +
Sbjct: 256 GAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVV 315
Query: 249 ELL---GATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAKEVNSA 305
ELL GA + + ++ L L + ++ PV + DY ++ A
Sbjct: 316 ELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTL---DYLTALHVA 372
Query: 306 EELEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINLW-KYA 364
A R+ LL+ +R ++P+ + A N + + L KY
Sbjct: 373 -------AHCGHYRVTKLLLDKR----ANPNARALNGFTPLHIACKKNRIKVMELLVKYG 421
Query: 365 LDMQQSNLDPLSPMTASSLLSFAELFSFMLQDRAKGLLGTTVTFDDLMGILCKSVLEIER 424
+Q L+P+ ++ + + +LQ+ A D+ I ++ L +
Sbjct: 422 ASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGAS---------PDVTNIRGETALHMAA 472
Query: 425 AIKQTQCPADPLQLNKALSIILHLICLLEKVPCTLEQDHFKKQTIYRFLK--LHPRG--K 480
Q + L+ N AL + E+ P + K + + L+ HP
Sbjct: 473 RAGQVEVVRCLLR-NGAL---VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATT 528
Query: 481 NNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNH 540
N ++PLH++ + + V ++L+E GA ++ +PLH+AA
Sbjct: 529 NGYTPLHISAREG-------------QVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGS 575
Query: 541 PDIMNLLIKSGAHFDA 556
D+ LL++ A D+
Sbjct: 576 LDVAKLLLQRRAAADS 591
Score = 87.4 bits (215), Expect = 3e-17
Identities = 69/234 (29%), Positives = 111/234 (47%), Gaps = 15/234 (6%)
Query: 4 KTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQ 63
+T + A+R GK ++ LL + + ++ TNG TPL ++AR G +D+ LLE
Sbjct: 498 QTPLHIASRLGKTEIVQLLLQHMAHPDAAT-----TNGYTPLHISAREGQVDVASVLLEA 552
Query: 64 CSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAA 123
+A T +G PL A+ G L V + LL A+ ++ TPL A
Sbjct: 553 GAAHSLA---------TKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVA 603
Query: 124 CFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGN 183
+ ++ L+E A + ++G+T L I+ K +IA LL GA+ N + +G
Sbjct: 604 AHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV 663
Query: 184 TALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFLTHH 236
T LH ++ G D++ +LL A + G+T L A+ N+ D LT H
Sbjct: 664 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKH 717
Score = 77.4 bits (189), Expect = 4e-14
Identities = 50/166 (30%), Positives = 84/166 (50%), Gaps = 9/166 (5%)
Query: 37 EKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHL 96
+K++ L AAR G+LD V L+ G ++ + G L A+ GH+
Sbjct: 27 KKSDSNASFLRAARAGNLDKVVEYLK---------GGIDINTCNQNGLNALHLAAKEGHV 77
Query: 97 KVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMIS 156
+VQ LL G+SV++ T +T L A G E+VK LV+ A++ +++G T L ++
Sbjct: 78 GLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMA 137
Query: 157 CYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLL 202
+ H ++ +YLLE GA+ + + G T L + G + +LL
Sbjct: 138 AQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183
Score = 45.8 bits (107), Expect = 1e-04
Identities = 30/110 (27%), Positives = 54/110 (49%), Gaps = 20/110 (18%)
Query: 475 LHPRGKNNFSPLHLAVDKNT-----------------TCVGRYPV---CKFPSLQVTAIL 514
+H K+ + LHLA ++ T +G P+ C + ++++ L
Sbjct: 688 IHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFL 747
Query: 515 IECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTA 564
++ GA+VN + + +PLH AA H I+N+L++ GA +AT + TA
Sbjct: 748 LKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTA 797
Score = 30.8 bits (68), Expect = 3.8
Identities = 27/99 (27%), Positives = 43/99 (43%), Gaps = 7/99 (7%)
Query: 459 LEQDHFKKQTIYRFLKLHPRGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECG 518
L+Q H Q + L+ +GK LH+A K+ T + + V + ++
Sbjct: 171 LQQGH--NQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMM--- 225
Query: 519 ADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDAT 557
VN +PLHIAA + ++ LL+ GA D T
Sbjct: 226 --VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT 262
Score = 30.4 bits (67), Expect = 5.0
Identities = 17/65 (26%), Positives = 32/65 (49%), Gaps = 3/65 (4%)
Query: 518 GADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTA---SDLLDEKEIA 574
G D+N + + + LH+AA H ++ L+ G+ D+ TA + L + E+
Sbjct: 54 GIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVV 113
Query: 575 KNLIQ 579
K L++
Sbjct: 114 KVLVK 118
Score = 30.0 bits (66), Expect = 6.6
Identities = 28/108 (25%), Positives = 49/108 (45%), Gaps = 22/108 (20%)
Query: 478 RGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAAL 537
R + +PLH+A T ++ +L++ A + ++ +PLHI+A
Sbjct: 493 RAREEQTPLHIASRLGKT-------------EIVQLLLQHMAHPDAATTNGYTPLHISAR 539
Query: 538 NNHPDIMNLLIKSG-AHFDATN-----LHKQTASDLLDEKEIAKNLIQ 579
D+ ++L+++G AH AT LH LD +AK L+Q
Sbjct: 540 EGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLD---VAKLLLQ 584
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 110 bits (275), Expect = 4e-24
Identities = 70/242 (28%), Positives = 123/242 (50%), Gaps = 15/242 (6%)
Query: 5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQC 64
T + AA G + + T LL + + ++ N TPL +A++ G+ +MV+ LL++
Sbjct: 237 TPLHIAAHYGNINVATLLLNRAAAVDFTA-----RNDITPLHVASKRGNANMVKLLLDR- 290
Query: 65 SASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAAC 124
D +T +G PL + +GH +VV+ LL+ A + + T +PL A
Sbjct: 291 --------GAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMAT 342
Query: 125 FDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNT 184
HL V+ L++H ++ T L ++ + GH ++A+ LL+K A+ N K++ G T
Sbjct: 343 QGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFT 402
Query: 185 ALHDCAESGSLDIMKMLLMYCAKMEK-DGYGMTPLLSASVTGHTNIVDFLTHHAQTSKTE 243
LH + + +M++LL + A ++ G+TP+ A+ GH NIV L HH + T
Sbjct: 403 PLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTT 462
Query: 244 RI 245
+
Sbjct: 463 NV 464
Score = 109 bits (273), Expect = 7e-24
Identities = 76/257 (29%), Positives = 117/257 (45%), Gaps = 30/257 (11%)
Query: 5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQ- 63
T + AR G +++ LL + + ++S+ NG +PL MA + HL+ V+ LL+
Sbjct: 303 TPLHCGARSGHEQVVEMLL-----DRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHN 357
Query: 64 -------------------CS----ASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQ 100
C A + + N + + + G PL A +KV++
Sbjct: 358 VPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVME 417
Query: 101 SLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKG 160
LL HGAS+ T + TP+ A F GH+ IV L+ H A +N G T L ++ G
Sbjct: 418 LLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSG 477
Query: 161 HKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLL 219
E+ +YL++ GA V K+ T LH A G DI++ LL A G TPL
Sbjct: 478 QAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLH 537
Query: 220 SASVTGHTNIVDFLTHH 236
++ GH ++ FL H
Sbjct: 538 LSAREGHEDVAAFLLDH 554
Score = 108 bits (270), Expect = 1e-23
Identities = 119/499 (23%), Positives = 204/499 (40%), Gaps = 68/499 (13%)
Query: 90 ASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHG 149
A+ AGHL+ + +G +N L A +GH+E+V L++ +A+++ + + G
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
Query: 150 HTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKME 209
+T L I+ G E+ + L+ GA+VN +S G T L+ A+ L+++K LL A
Sbjct: 108 NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQS 167
Query: 210 ---KDGYGMTPLLSASVTGHTNIVDFLTHHAQTSKTERINALELLGATFVDKKRDLLGAL 266
+DG+ TPL A GH +V L + K R+ AL + +K D A
Sbjct: 168 LATEDGF--TPLAVALQQGHDQVVSLLLENDTKGKV-RLPALHIAA-----RKDDTKAA- 218
Query: 267 KYWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAKEVNSAEELEGLIADPDEMRMQALLIR 326
A+ ++ + ++ SK L +A Y +N A L A D
Sbjct: 219 -----ALLLQNDNNADVESKSGFTPLHIAAHYG-NINVATLLLNRAAAVD-------FTA 265
Query: 327 ERILGPSHPDTSYYIRYRGAVYADSGNFKRCINLWKYALDMQQSNLDPLSPMTASSLLSF 386
+ P H V + GN L + D L+P+ +
Sbjct: 266 RNDITPLH------------VASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGH 313
Query: 387 AELFSFMLQDRAKGLLGTTVT-FDDLMGILCKSVLEIERAIKQTQCPADPLQLNKALSII 445
++ ML DRA +L T L L + + Q P D + + ++
Sbjct: 314 EQVVE-MLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALH 372
Query: 446 LHLICLLEKVPCTLEQDHFKKQTIYRFLKLHPRGK--NNFSPLHLAVDKNTTCVGRYPVC 503
+ C H+K + K +P K N F+PLH+A C
Sbjct: 373 VAAHC-----------GHYKVAKVLLDKKANPNAKALNGFTPLHIA-------------C 408
Query: 504 KFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQT 563
K ++V +L++ GA + +P+H+AA H +I++ L+ GA + TN+ +T
Sbjct: 409 KKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGET 468
Query: 564 ASDLL---DEKEIAKNLIQ 579
A + + E+ + L+Q
Sbjct: 469 ALHMAARSGQAEVVRYLVQ 487
Score = 106 bits (265), Expect = 6e-23
Identities = 132/620 (21%), Positives = 237/620 (38%), Gaps = 91/620 (14%)
Query: 5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQC 64
T ++ AA++ L ++ LL + + + +++ +G TPL +A + GH +V LLE
Sbjct: 142 TPLYMAAQENHLEVVKFLLDNGASQSLAT-----EDGFTPLAVALQQGHDQVVSLLLEND 196
Query: 65 S--------------------ASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLN 104
+ A++ + N D E+ G PL A+ G++ V LLN
Sbjct: 197 TKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLN 256
Query: 105 HGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEI 164
A+V+ T + TPL A G+ +VK L++ A ++ R G T L GH+++
Sbjct: 257 RAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQV 316
Query: 165 AQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKME--KDGYGMTPLLSAS 222
+ LL++ A + K+ G + LH + L+ +++LL + ++ + Y +T L A+
Sbjct: 317 VEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDY-LTALHVAA 375
Query: 223 VTGHTNIVDFLTHHAQTSKTERINALELLGATFVDKKRDLLG-ALKYWKKAMNMRYSDRT 281
GH + L + +N L + ++ LK+ + S T
Sbjct: 376 HCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLT 435
Query: 282 NIISKPVPQTLIMAYDYAKEVNSAEELEGLIADPDEMRMQALLIRERILGPSHPDTSYYI 341
P+ M + VN +L A P+ ++ + Y+
Sbjct: 436 -----PIHVAAFMGH-----VNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYL 485
Query: 342 RYRGA--------------VYADSGNFKRCINLWKYALDMQQSNLDPLSPMTASSLLSFA 387
GA + A G L + + +P+ S+
Sbjct: 486 VQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHE 545
Query: 388 ELFSFMLQDRAKGLLGTTVTFDDLMGILCKSVLEIERAIKQTQCPADPLQLNKALSIILH 447
++ +F+L A + T F L LE+ + Q A P K+ LH
Sbjct: 546 DVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKS--ASPDAAGKSGLTPLH 603
Query: 448 LICLLEKVPCTLEQDHFKKQTIYRFL-----KLHPRGKNNFSPLHLAVDKNTTCVGRYPV 502
+ H+ Q + L H KN ++PLH+A KN
Sbjct: 604 VAA------------HYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKN--------- 642
Query: 503 CKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATN---- 558
+ + L+E GAD N + +H+AA H D+++LL+ A+ + +N
Sbjct: 643 ----QMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGL 698
Query: 559 --LHKQTASDLLDEKEIAKN 576
LH D ++ E+ N
Sbjct: 699 TPLHLAAQEDRVNVAEVLVN 718
Score = 105 bits (263), Expect = 9e-23
Identities = 76/233 (32%), Positives = 110/233 (47%), Gaps = 15/233 (6%)
Query: 2 DLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLL 61
D TA+ AA G ++ LL K+ +L NG TPL +A + + ++E LL
Sbjct: 366 DYLTALHVAAHCGHYKVAKVLLDKKANPNAKAL-----NGFTPLHIACKKNRIKVMELLL 420
Query: 62 EQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLR 121
+ ASI+ T G P+ A+ GH+ +V L++HGAS N T + T L
Sbjct: 421 KH-GASIQA--------VTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALH 471
Query: 122 AACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVK 181
A G E+V+YLV+ A +E + T L IS G +I Q LL++GA N +
Sbjct: 472 MAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTS 531
Query: 182 GNTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFL 233
G T LH A G D+ LL + A + G TPL A+ G + + L
Sbjct: 532 GYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLL 584
Score = 98.2 bits (243), Expect = 2e-20
Identities = 89/335 (26%), Positives = 152/335 (45%), Gaps = 22/335 (6%)
Query: 5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQC 64
T + AA+ GKL + LL + + + +G TPL +AA Y + + LL+Q
Sbjct: 567 TPLHVAAKYGKLEVANLLLQKSASPDAAG-----KSGLTPLHVAAHYDNQKVALLLLDQ- 620
Query: 65 SASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAAC 124
G S + + G PL A+ + + +LL +GA N T + A
Sbjct: 621 ------GASPHAAAKN--GYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAA 672
Query: 125 FDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNT 184
+GH+++V L+ A++ +SN+ G T L ++ + +A+ L+ +GA V+ ++ G T
Sbjct: 673 QEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYT 732
Query: 185 ALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFLTHHAQTSKTE 243
LH G++ I+ LL + AK+ K G TPL A+ GHT+I++ L + +
Sbjct: 733 PLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNEL 792
Query: 244 RINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQT----LIMAYDYA 299
+N LG ++ LK + M + T VP+T L M+ D
Sbjct: 793 TVNGNTALGIARRLGYISVVDTLKIVTEE-TMTTTTVTEKHKMNVPETMNEVLDMSDDEV 851
Query: 300 KEVNSAEELEG--LIADPDEMRMQALLIRERILGP 332
++ N+ E L I+D +E ++ LGP
Sbjct: 852 RKANAPEMLSDGEYISDVEEGEDAMTGDTDKYLGP 886
Score = 97.1 bits (240), Expect = 4e-20
Identities = 71/231 (30%), Positives = 115/231 (49%), Gaps = 15/231 (6%)
Query: 4 KTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQ 63
+TA+ AAR G+ ++ L+ ++ E + + TPL ++AR G D+V+ LL+Q
Sbjct: 467 ETALHMAARSGQAEVVRYLVQDGAQVEAKA-----KDDQTPLHISARLGKADIVQQLLQQ 521
Query: 64 CSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAA 123
G S N T G PL ++ GH V LL+HGAS++ TT TPL A
Sbjct: 522 -------GASPN--AATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVA 572
Query: 124 CFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGN 183
G LE+ L++ A + + + G T L ++ + ++++A LL++GA + + G
Sbjct: 573 AKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGY 632
Query: 184 TALHDCAESGSLDIMKMLLMYCAKMEK-DGYGMTPLLSASVTGHTNIVDFL 233
T LH A+ +DI LL Y A G+ + A+ GH ++V L
Sbjct: 633 TPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLL 683
Score = 92.8 bits (229), Expect = 8e-19
Identities = 70/235 (29%), Positives = 118/235 (50%), Gaps = 15/235 (6%)
Query: 2 DLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLL 61
D +T + +AR GK ++ +LL + ++ T+G TPL ++AR GH D+ FLL
Sbjct: 498 DDQTPLHISARLGKADIVQQLLQQGASPNAAT-----TSGYTPLHLSAREGHEDVAAFLL 552
Query: 62 EQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLR 121
+ AS+ + T +G PL A+ G L+V LL AS + + TPL
Sbjct: 553 DH-GASLSI--------TTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLH 603
Query: 122 AACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVK 181
A + ++ L++ A + ++G+T L I+ K +IA LLE GAD N + +
Sbjct: 604 VAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQ 663
Query: 182 GNTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFLTH 235
G ++H A+ G +D++ +LL A + + G+TPL A+ N+ + L +
Sbjct: 664 GIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVN 718
Score = 88.2 bits (217), Expect = 2e-17
Identities = 67/226 (29%), Positives = 105/226 (46%), Gaps = 43/226 (19%)
Query: 40 NGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVV 99
NG L +A++ GH+++V LL++ N D T +G L AS AG +VV
Sbjct: 73 NGLNALHLASKEGHVEVVSELLQR---------EANVDAATKKGNTALHIASLAGQAEVV 123
Query: 100 QSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYK 159
+ L+ +GA+VN + TPL A + HLE+VK+L+++ A ++ G T L ++ +
Sbjct: 124 KVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQ 183
Query: 160 GHKEIAQYLLE-------------------------------KGADVNRKSVKGNTALHD 188
GH ++ LLE ADV KS G T LH
Sbjct: 184 GHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKS--GFTPLHI 241
Query: 189 CAESGSLDIMKMLLMYCAKMEKDGYG-MTPLLSASVTGHTNIVDFL 233
A G++++ +LL A ++ +TPL AS G+ N+V L
Sbjct: 242 AAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLL 287
Score = 80.5 bits (197), Expect = 4e-15
Identities = 66/231 (28%), Positives = 106/231 (45%), Gaps = 39/231 (16%)
Query: 36 SEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGH 95
++ NG TPL MAA+ HL++V+FLL+ G S + T +G PL A GH
Sbjct: 135 AQSQNGFTPLYMAAQENHLEVVKFLLDN-------GASQSL--ATEDGFTPLAVALQQGH 185
Query: 96 LKVVQSLLNHGA--------------------------SVNNTTLTNS---TPLRAACFD 126
+VV LL + + NN + + TPL A
Sbjct: 186 DQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHY 245
Query: 127 GHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTAL 186
G++ + L+ A ++ + R+ T L ++ +G+ + + LL++GA ++ K+ G T L
Sbjct: 246 GNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPL 305
Query: 187 HDCAESGSLDIMKMLLMYCAK-MEKDGYGMTPLLSASVTGHTNIVDFLTHH 236
H A SG +++MLL A + K G++PL A+ H N V L H
Sbjct: 306 HCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQH 356
Score = 40.4 bits (93), Expect = 0.005
Identities = 26/105 (24%), Positives = 50/105 (47%), Gaps = 20/105 (19%)
Query: 480 KNNFSPLHLAVDKNT-----------------TCVGRYPV---CKFPSLQVTAILIECGA 519
K+ +PLHLA ++ T +G P+ C + ++++ L++ A
Sbjct: 695 KSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSA 754
Query: 520 DVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTA 564
VN + + +PLH AA H I+N+L+++ A + ++ TA
Sbjct: 755 KVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTA 799
Score = 39.7 bits (91), Expect = 0.008
Identities = 33/141 (23%), Positives = 61/141 (43%), Gaps = 36/141 (25%)
Query: 480 KNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNN 539
K+ F+PLH+A + ++ V +L+ A V+ +D +PLH+A+
Sbjct: 233 KSGFTPLHIAAH-------------YGNINVATLLLNRAAAVDFTARNDITPLHVASKRG 279
Query: 540 HPDIMNLLIKSGAHFDATNL-------------HKQTASDLLDEK----EIAKNLIQPIN 582
+ +++ LL+ GA DA H+Q LLD KN + P++
Sbjct: 280 NANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLH 339
Query: 583 HTT----LQCLAARVIVNHRI 599
T L C+ ++++ H +
Sbjct: 340 MATQGDHLNCV--QLLLQHNV 358
Score = 34.3 bits (77), Expect = 0.35
Identities = 33/132 (25%), Positives = 57/132 (43%), Gaps = 23/132 (17%)
Query: 480 KNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNN 539
K F+PLH+A K+ L+V +L++ A + +PLH+AA +
Sbjct: 563 KKGFTPLHVAA-------------KYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYD 609
Query: 540 HPDIMNLLIKSGAHFDATNLHKQTASDLLDEK---EIAKNLIQ---PINHTTLQCLAARV 593
+ + LL+ GA A + T + +K +IA L++ N T Q +A+
Sbjct: 610 NQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIAS-- 667
Query: 594 IVNHRIYYKGHI 605
H +GH+
Sbjct: 668 --VHLAAQEGHV 677
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 108 bits (270), Expect = 1e-23
Identities = 83/237 (35%), Positives = 117/237 (49%), Gaps = 28/237 (11%)
Query: 23 LASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQ------------------- 63
LA+ E ++L G TPL+ AAR GH +MV LL Q
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
Query: 64 -CSASIEVGGSVNFDGETIE--GAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPL 120
C EV + G IE + PL AS GHL++V+ LL GA+V+ TT T T L
Sbjct: 513 CCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 572
Query: 121 RAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSV 180
AC +GH ++ L++ ADLE + G T LM + GH Q+L+ KGA+VNR +
Sbjct: 573 TYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATA 632
Query: 181 KG-NTALHDCAESGSLDIMKMLLMYCAKME---KDGYGMTPLLSASVTGHTNIVDFL 233
+T + G L ++++LL + A KD G T L+ A+ GHTN+V +L
Sbjct: 633 NNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKD--GSTMLIEAAKGGHTNVVSYL 687
Score = 106 bits (265), Expect = 6e-23
Identities = 76/234 (32%), Positives = 119/234 (50%), Gaps = 19/234 (8%)
Query: 2 DLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLL 61
++ TA+ A DG + + LL S ++ + + E +PL +AA GH+++ L+
Sbjct: 404 EMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE-----SPLTLAACGGHVELAALLI 458
Query: 62 EQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVN-NTTLTNSTPL 120
E+ N + EG PL A+ GH ++V LL GA++N T T T L
Sbjct: 459 ER---------GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETAL 509
Query: 121 RAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSV 180
AC G E+ +L++ AD+E+ T LM + +GH E+ +YLL GA+V+ +
Sbjct: 510 TLACCGGFSEVADFLIKAGADIELG---CSTPLMEASQEGHLELVKYLLASGANVHATTA 566
Query: 181 KGNTALHDCAESGSLDIMKMLLMYCAKMEKDGY-GMTPLLSASVTGHTNIVDFL 233
G+TAL E+G D+ +LL A +E + G TPL+ A+ GH V FL
Sbjct: 567 TGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFL 620
Score = 100 bits (248), Expect = 5e-21
Identities = 75/226 (33%), Positives = 114/226 (50%), Gaps = 15/226 (6%)
Query: 10 AARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIE 69
A DG + + KLL +E S+ G + L +A G+ ++ + LL A++E
Sbjct: 212 ACSDGDVNAVRKLL-----DEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAM-HANVE 265
Query: 70 VGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHL 129
G+ PL AAS+ G+L +V+ LL H A VN+ + T +T L AC G +
Sbjct: 266 DRGNKG-------DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFV 318
Query: 130 EIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVK-GNTALHD 188
+IVK L+ A++E N +GHT LM + GH E+A+ LL+ GA +N S + +AL
Sbjct: 319 DIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTL 378
Query: 189 CAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFL 233
G LD+++ LL A E K T L+ A + GH + L
Sbjct: 379 ACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 424
Score = 98.2 bits (243), Expect = 2e-20
Identities = 73/228 (32%), Positives = 117/228 (51%), Gaps = 16/228 (7%)
Query: 10 AARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIE 69
A G+ ++ LLA + +E + TPL +AA G++++++ LL
Sbjct: 1129 ACSGGRQEVVDLLLARGANKE-----HRNVSDYTPLSLAASGGYVNIIKILLN------- 1176
Query: 70 VGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTN-STPLRAACFDGH 128
G +N + G PL A+ GH+ V+ LL+ G+ +N TN +T L ACF G
Sbjct: 1177 AGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1236
Query: 129 LEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKG--NTAL 186
E+V L++ KA++E + G T LM + G+ E+ + LL+KGADVN V +TAL
Sbjct: 1237 AEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1296
Query: 187 HDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFL 233
A+ G ++L+ A ++ ++ G TPL AS GH ++V L
Sbjct: 1297 TIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLL 1344
Score = 97.8 bits (242), Expect = 3e-20
Identities = 61/194 (31%), Positives = 103/194 (53%), Gaps = 13/194 (6%)
Query: 43 TPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSL 102
TPL+ A+ G+LD+V+ LL + + ++ G L A A G + +V+ L
Sbjct: 274 TPLMAASSGGYLDIVKLLLLH---------DADVNSQSATGNTALTYACAGGFVDIVKVL 324
Query: 103 LNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEV-SNRHGHTCLMISCYKGH 161
LN GA++ + TPL A GH+E+ + L++H A + SN + L ++CYKGH
Sbjct: 325 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH 384
Query: 162 KEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAK--MEKDGYGMTPLL 219
++ ++LLE GAD K+ + +TAL + G +++ ++LL A+ M D + +PL
Sbjct: 385 LDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF-ESPLT 443
Query: 220 SASVTGHTNIVDFL 233
A+ GH + L
Sbjct: 444 LAACGGHVELAALL 457
Score = 94.0 bits (232), Expect = 4e-19
Identities = 76/255 (29%), Positives = 128/255 (50%), Gaps = 20/255 (7%)
Query: 10 AARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIE 69
AA G + ++ LL + + E++S K G +PL++AA GH+ V+ LL+
Sbjct: 1162 AASGGYVNIIKILLNAGA--EINSRTGSKL-GISPLMLAAMNGHVPAVKLLLD------- 1211
Query: 70 VGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHL 129
+G +N ET L A G +VV LL+ A+V + T TPL A G+
Sbjct: 1212 MGSDINAQIETNRNTA-LTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYA 1270
Query: 130 EIVKYLVEHKADLEV----SNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTA 185
E+ + L++ AD+ S+R T L I+ KGH + + L+ +GA ++ ++ KGNT
Sbjct: 1271 EVGRVLLDKGADVNAPPVPSSRD--TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTP 1328
Query: 186 LHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFLTHHAQTSKTER 244
L + G D++++L+ A ++ D +TPL+SA GH +V +L ++
Sbjct: 1329 LWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSD- 1387
Query: 245 INALELLGATFVDKK 259
I + + AT DK+
Sbjct: 1388 IECMRYI-ATITDKE 1401
Score = 91.3 bits (225), Expect = 2e-18
Identities = 65/190 (34%), Positives = 97/190 (51%), Gaps = 12/190 (6%)
Query: 45 LLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLN 104
L +A GHLDMV FLLE + + +T E L A GH++V + LL+
Sbjct: 376 LTLACYKGHLDMVRFLLE---------AGADQEHKTDEMHTALMEACMDGHVEVARLLLD 426
Query: 105 HGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEI 164
GA VN + +PL A GH+E+ L+E A+LE N G+T LM + +GH+E+
Sbjct: 427 SGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEM 486
Query: 165 AQYLLEKGADVNRKSVK-GNTALHDCAESGSLDIMKMLLMYCAKMEKDGYGMTPLLSASV 223
LL +GA++N ++ + TAL G ++ L+ A +E TPL+ AS
Sbjct: 487 VALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELG--CSTPLMEASQ 544
Query: 224 TGHTNIVDFL 233
GH +V +L
Sbjct: 545 EGHLELVKYL 554
Score = 77.8 bits (190), Expect = 3e-14
Identities = 53/149 (35%), Positives = 76/149 (51%), Gaps = 2/149 (1%)
Query: 90 ASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHG 149
A + G + V+ LL+ G SVN T + L AC G+ E+ + L+ A++E G
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 150 H-TCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKM 208
T LM + G+ +I + LL ADVN +S GNTAL G +DI+K+LL A +
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331
Query: 209 EKDGY-GMTPLLSASVTGHTNIVDFLTHH 236
E G TPL+ A+ GH + L H
Sbjct: 332 EDHNENGHTPLMEAASAGHVEVARVLLDH 360
Score = 68.6 bits (166), Expect = 2e-11
Identities = 65/241 (26%), Positives = 106/241 (43%), Gaps = 25/241 (10%)
Query: 38 KTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLK 97
++N T L +A GH ++V L+ + + +G PL A+ AGH+
Sbjct: 1052 ESNHDTALTLACAGGHEELVSVLIAR---------DAKIEHRDKKGFTPLILAATAGHVG 1102
Query: 98 VVQSLLNHGASVN-NTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMIS 156
VV+ LL+ G + + T TPL AC G E+V L+ A+ E N +T L ++
Sbjct: 1103 VVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLA 1162
Query: 157 CYKGHKEIAQYLLEKGADVNRK--SVKGNTALHDCAESGSLDIMKMLLMYCAKM--EKDG 212
G+ I + LL GA++N + S G + L A +G + +K+LL + + + +
Sbjct: 1163 ASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIET 1222
Query: 213 YGMTPLLSASVTGHTNIVDFL-------THHAQTSKTERINALE----LLGATFVDKKRD 261
T L A G +V L H A+T T + A +G +DK D
Sbjct: 1223 NRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGAD 1282
Query: 262 L 262
+
Sbjct: 1283 V 1283
Score = 67.0 bits (162), Expect = 5e-11
Identities = 48/167 (28%), Positives = 81/167 (48%), Gaps = 12/167 (7%)
Query: 5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQC 64
TA+ A G+ +++ LL K+ E G TPL+ AA G+ ++ LL++
Sbjct: 1226 TALTLACFQGRAEVVSLLLDRKANVE-----HRAKTGLTPLMEAASGGYAEVGRVLLDK- 1279
Query: 65 SASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAAC 124
G VN L A+ GH K + L++ GA ++ +TPL A
Sbjct: 1280 ------GADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLAS 1333
Query: 125 FDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEK 171
GH ++V+ LV+ AD++ ++ T LM + KGH ++ QYL+++
Sbjct: 1334 NGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
Score = 60.5 bits (145), Expect = 5e-09
Identities = 38/125 (30%), Positives = 64/125 (51%), Gaps = 2/125 (1%)
Query: 111 NTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLE 170
+T + T L AC GH E+V L+ A +E ++ G T L+++ GH + + LL+
Sbjct: 1050 HTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLD 1109
Query: 171 KGADVNRKSVK-GNTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTN 228
KG D+ +S + +T L G +++ +LL A E ++ TPL A+ G+ N
Sbjct: 1110 KGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVN 1169
Query: 229 IVDFL 233
I+ L
Sbjct: 1170 IIKIL 1174
Score = 57.8 bits (138), Expect = 3e-08
Identities = 39/107 (36%), Positives = 54/107 (50%), Gaps = 8/107 (7%)
Query: 32 SSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAAS 91
+ L E G TPL+ AAR GHL V+FL+ + A++ + N D + A
Sbjct: 592 ADLEHESEGGRTPLMKAARAGHLCTVQFLISK-GANVN-RATANNDHTVVS------LAC 643
Query: 92 AAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEH 138
A GHL VV+ LL HGA + ST L A GH +V YL+++
Sbjct: 644 AGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
Score = 44.3 bits (103), Expect = 3e-04
Identities = 27/78 (34%), Positives = 42/78 (53%), Gaps = 13/78 (16%)
Query: 486 LHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMN 545
L +A DK G Y C+ +LI GA ++VR+ N+PL +A+ H D++
Sbjct: 1296 LTIAADK-----GHYKFCE--------LLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQ 1342
Query: 546 LLIKSGAHFDATNLHKQT 563
LL+++GA DA + K T
Sbjct: 1343 LLVQAGADVDAADNRKIT 1360
Score = 39.3 bits (90), Expect = 0.011
Identities = 19/56 (33%), Positives = 31/56 (55%)
Query: 503 CKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATN 558
C ++V +L++ GA VN+ SPL +AA H ++ LLI+ GA+ + N
Sbjct: 413 CMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVN 468
Score = 36.2 bits (82), Expect = 0.092
Identities = 86/385 (22%), Positives = 142/385 (36%), Gaps = 69/385 (17%)
Query: 183 NTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFLTH-----H 236
+TAL G +++ +L+ AK+E +D G TPL+ A+ GH +V+ L
Sbjct: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115
Query: 237 AQTSKTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAY 296
AQ+ +T+ L L + + DLL A K+ N+ SD T P +L +
Sbjct: 1116 AQSERTKD-TPLSLACSGGRQEVVDLLLARGANKEHRNV--SDYT-------PLSLAASG 1165
Query: 297 DYAKEVNSAEELEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKR 356
Y VN + L A+ + L I +L A +G+
Sbjct: 1166 GY---VNIIKILLNAGAEINSRTGSKLGISPLMLA-----------------AMNGHVPA 1205
Query: 357 CINLWKYALDMQ-QSNLDPLSPMTASSLLSFAELFSFMLQDRAKGLLGTTVTFDDLMGIL 415
L D+ Q + + +T + AE+ S +L +A LM
Sbjct: 1206 VKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAA 1265
Query: 416 CKSVLEIERAI----KQTQCPADPLQLNKALSIILHLICLLEKVPCTLEQDHFK--KQTI 469
E+ R + P P + AL+I ++ H+K + I
Sbjct: 1266 SGGYAEVGRVLLDKGADVNAPPVPSSRDTALTI-------------AADKGHYKFCELLI 1312
Query: 470 YRFLKLHPRGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDN 529
+R + R K +PL LA + V +L++ GADV+ D+
Sbjct: 1313 HRGAHIDVRNKKGNTPLWLASNGG-------------HFDVVQLLVQAGADVDAADNRKI 1359
Query: 530 SPLHIAALNNHPDIMNLLIKSGAHF 554
+PL A H ++ L+K F
Sbjct: 1360 TPLMSAFRKGHVKVVQYLVKEVNQF 1384
Score = 34.3 bits (77), Expect = 0.35
Identities = 28/83 (33%), Positives = 34/83 (40%), Gaps = 15/83 (18%)
Query: 478 RGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRD--SDDNSPLHIA 535
R K +PL A VGR +L++ GADVN S ++ L IA
Sbjct: 1253 RAKTGLTPLMEAASGGYAEVGR-------------VLLDKGADVNAPPVPSSRDTALTIA 1299
Query: 536 ALNNHPDIMNLLIKSGAHFDATN 558
A H LLI GAH D N
Sbjct: 1300 ADKGHYKFCELLIHRGAHIDVRN 1322
Score = 33.9 bits (76), Expect = 0.45
Identities = 24/81 (29%), Positives = 39/81 (48%), Gaps = 15/81 (18%)
Query: 478 RGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDN--SPLHIA 535
R ++++PL LA G Y + + IL+ GA++N R SPL +A
Sbjct: 1151 RNVSDYTPLSLAAS------GGY-------VNIIKILLNAGAEINSRTGSKLGISPLMLA 1197
Query: 536 ALNNHPDIMNLLIKSGAHFDA 556
A+N H + LL+ G+ +A
Sbjct: 1198 AMNGHVPAVKLLLDMGSDINA 1218
Score = 33.5 bits (75), Expect = 0.59
Identities = 20/61 (32%), Positives = 37/61 (60%), Gaps = 1/61 (1%)
Query: 508 LQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDA-TNLHKQTASD 566
+++ A+LIE GA++ + + +PL AA H +++ LL+ GA+ +A T ++TA
Sbjct: 451 VELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALT 510
Query: 567 L 567
L
Sbjct: 511 L 511
Score = 33.1 bits (74), Expect = 0.78
Identities = 25/100 (25%), Positives = 44/100 (44%), Gaps = 14/100 (14%)
Query: 469 IYRFLKLHPRGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVR-DSD 527
I R K+ R K F+PL LA + V IL++ G D+ + +
Sbjct: 1075 IARDAKIEHRDKKGFTPLILAATAG-------------HVGVVEILLDKGGDIEAQSERT 1121
Query: 528 DNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTASDL 567
++PL +A ++++LL+ GA+ + N+ T L
Sbjct: 1122 KDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSL 1161
Score = 30.8 bits (68), Expect = 3.8
Identities = 19/56 (33%), Positives = 30/56 (53%), Gaps = 3/56 (5%)
Query: 509 QVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTA 564
+V LI+ GAD+ + S +PL A+ H +++ L+ SGA+ AT TA
Sbjct: 519 EVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTA 571
Score = 30.4 bits (67), Expect = 5.0
Identities = 15/50 (30%), Positives = 26/50 (52%)
Query: 503 CKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGA 552
C L + L+E GAD + + ++ L A ++ H ++ LL+ SGA
Sbjct: 380 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGA 429
Score = 30.4 bits (67), Expect = 5.0
Identities = 13/48 (27%), Positives = 28/48 (58%)
Query: 508 LQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFD 555
L++ L+ GA+V+ + ++ L A N H D+ ++L+++GA +
Sbjct: 548 LELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 595
Score = 30.0 bits (66), Expect = 6.6
Identities = 16/56 (28%), Positives = 28/56 (50%)
Query: 508 LQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQT 563
L + +L+ ADVN + + N+ L A DI+ +L+ GA+ + N + T
Sbjct: 285 LDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHT 340
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 108 bits (270), Expect = 1e-23
Identities = 83/237 (35%), Positives = 117/237 (49%), Gaps = 28/237 (11%)
Query: 23 LASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQ------------------- 63
LA+ E ++L G TPL+ AAR GH +MV LL Q
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
Query: 64 -CSASIEVGGSVNFDGETIE--GAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPL 120
C EV + G IE + PL AS GHL++V+ LL GA+V+ TT T T L
Sbjct: 513 CCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 572
Query: 121 RAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSV 180
AC +GH ++ L++ ADLE + G T LM + GH Q+L+ KGA+VNR +
Sbjct: 573 TYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATA 632
Query: 181 KG-NTALHDCAESGSLDIMKMLLMYCAKME---KDGYGMTPLLSASVTGHTNIVDFL 233
+T + G L ++++LL + A KD G T L+ A+ GHTN+V +L
Sbjct: 633 NNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKD--GSTMLIEAAKGGHTNVVSYL 687
Score = 106 bits (265), Expect = 6e-23
Identities = 76/234 (32%), Positives = 119/234 (50%), Gaps = 19/234 (8%)
Query: 2 DLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLL 61
++ TA+ A DG + + LL S ++ + + E +PL +AA GH+++ L+
Sbjct: 404 EMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE-----SPLTLAACGGHVELAALLI 458
Query: 62 EQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVN-NTTLTNSTPL 120
E+ N + EG PL A+ GH ++V LL GA++N T T T L
Sbjct: 459 ER---------GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETAL 509
Query: 121 RAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSV 180
AC G E+ +L++ AD+E+ T LM + +GH E+ +YLL GA+V+ +
Sbjct: 510 TLACCGGFSEVADFLIKAGADIELG---CSTPLMEASQEGHLELVKYLLASGANVHATTA 566
Query: 181 KGNTALHDCAESGSLDIMKMLLMYCAKMEKDGY-GMTPLLSASVTGHTNIVDFL 233
G+TAL E+G D+ +LL A +E + G TPL+ A+ GH V FL
Sbjct: 567 TGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFL 620
Score = 100 bits (248), Expect = 5e-21
Identities = 75/226 (33%), Positives = 114/226 (50%), Gaps = 15/226 (6%)
Query: 10 AARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIE 69
A DG + + KLL +E S+ G + L +A G+ ++ + LL A++E
Sbjct: 212 ACSDGDVNAVRKLL-----DEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAM-HANVE 265
Query: 70 VGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHL 129
G+ PL AAS+ G+L +V+ LL H A VN+ + T +T L AC G +
Sbjct: 266 DRGNKG-------DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFV 318
Query: 130 EIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVK-GNTALHD 188
+IVK L+ A++E N +GHT LM + GH E+A+ LL+ GA +N S + +AL
Sbjct: 319 DIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTL 378
Query: 189 CAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFL 233
G LD+++ LL A E K T L+ A + GH + L
Sbjct: 379 ACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 424
Score = 98.2 bits (243), Expect = 2e-20
Identities = 73/228 (32%), Positives = 117/228 (51%), Gaps = 16/228 (7%)
Query: 10 AARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIE 69
A G+ ++ LLA + +E + TPL +AA G++++++ LL
Sbjct: 1129 ACSGGRQEVVDLLLARGANKE-----HRNVSDYTPLSLAASGGYVNIIKILLN------- 1176
Query: 70 VGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTN-STPLRAACFDGH 128
G +N + G PL A+ GH+ V+ LL+ G+ +N TN +T L ACF G
Sbjct: 1177 AGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1236
Query: 129 LEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKG--NTAL 186
E+V L++ KA++E + G T LM + G+ E+ + LL+KGADVN V +TAL
Sbjct: 1237 AEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1296
Query: 187 HDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFL 233
A+ G ++L+ A ++ ++ G TPL AS GH ++V L
Sbjct: 1297 TIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLL 1344
Score = 97.8 bits (242), Expect = 3e-20
Identities = 61/194 (31%), Positives = 103/194 (53%), Gaps = 13/194 (6%)
Query: 43 TPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSL 102
TPL+ A+ G+LD+V+ LL + + ++ G L A A G + +V+ L
Sbjct: 274 TPLMAASSGGYLDIVKLLLLH---------DADVNSQSATGNTALTYACAGGFVDIVKVL 324
Query: 103 LNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEV-SNRHGHTCLMISCYKGH 161
LN GA++ + TPL A GH+E+ + L++H A + SN + L ++CYKGH
Sbjct: 325 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH 384
Query: 162 KEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAK--MEKDGYGMTPLL 219
++ ++LLE GAD K+ + +TAL + G +++ ++LL A+ M D + +PL
Sbjct: 385 LDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF-ESPLT 443
Query: 220 SASVTGHTNIVDFL 233
A+ GH + L
Sbjct: 444 LAACGGHVELAALL 457
Score = 94.0 bits (232), Expect = 4e-19
Identities = 76/255 (29%), Positives = 128/255 (50%), Gaps = 20/255 (7%)
Query: 10 AARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIE 69
AA G + ++ LL + + E++S K G +PL++AA GH+ V+ LL+
Sbjct: 1162 AASGGYVNIIKILLNAGA--EINSRTGSKL-GISPLMLAAMNGHVPAVKLLLD------- 1211
Query: 70 VGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHL 129
+G +N ET L A G +VV LL+ A+V + T TPL A G+
Sbjct: 1212 MGSDINAQIETNRNTA-LTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYA 1270
Query: 130 EIVKYLVEHKADLEV----SNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTA 185
E+ + L++ AD+ S+R T L I+ KGH + + L+ +GA ++ ++ KGNT
Sbjct: 1271 EVGRVLLDKGADVNAPPVPSSRD--TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTP 1328
Query: 186 LHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFLTHHAQTSKTER 244
L + G D++++L+ A ++ D +TPL+SA GH +V +L ++
Sbjct: 1329 LWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSD- 1387
Query: 245 INALELLGATFVDKK 259
I + + AT DK+
Sbjct: 1388 IECMRYI-ATITDKE 1401
Score = 91.3 bits (225), Expect = 2e-18
Identities = 65/190 (34%), Positives = 97/190 (51%), Gaps = 12/190 (6%)
Query: 45 LLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLN 104
L +A GHLDMV FLLE + + +T E L A GH++V + LL+
Sbjct: 376 LTLACYKGHLDMVRFLLE---------AGADQEHKTDEMHTALMEACMDGHVEVARLLLD 426
Query: 105 HGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEI 164
GA VN + +PL A GH+E+ L+E A+LE N G+T LM + +GH+E+
Sbjct: 427 SGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEM 486
Query: 165 AQYLLEKGADVNRKSVK-GNTALHDCAESGSLDIMKMLLMYCAKMEKDGYGMTPLLSASV 223
LL +GA++N ++ + TAL G ++ L+ A +E TPL+ AS
Sbjct: 487 VALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELG--CSTPLMEASQ 544
Query: 224 TGHTNIVDFL 233
GH +V +L
Sbjct: 545 EGHLELVKYL 554
Score = 77.8 bits (190), Expect = 3e-14
Identities = 53/149 (35%), Positives = 76/149 (51%), Gaps = 2/149 (1%)
Query: 90 ASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHG 149
A + G + V+ LL+ G SVN T + L AC G+ E+ + L+ A++E G
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 150 H-TCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKM 208
T LM + G+ +I + LL ADVN +S GNTAL G +DI+K+LL A +
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331
Query: 209 EKDGY-GMTPLLSASVTGHTNIVDFLTHH 236
E G TPL+ A+ GH + L H
Sbjct: 332 EDHNENGHTPLMEAASAGHVEVARVLLDH 360
Score = 68.6 bits (166), Expect = 2e-11
Identities = 65/241 (26%), Positives = 106/241 (43%), Gaps = 25/241 (10%)
Query: 38 KTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLK 97
++N T L +A GH ++V L+ + + +G PL A+ AGH+
Sbjct: 1052 ESNHDTALTLACAGGHEELVSVLIAR---------DAKIEHRDKKGFTPLILAATAGHVG 1102
Query: 98 VVQSLLNHGASVN-NTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMIS 156
VV+ LL+ G + + T TPL AC G E+V L+ A+ E N +T L ++
Sbjct: 1103 VVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLA 1162
Query: 157 CYKGHKEIAQYLLEKGADVNRK--SVKGNTALHDCAESGSLDIMKMLLMYCAKM--EKDG 212
G+ I + LL GA++N + S G + L A +G + +K+LL + + + +
Sbjct: 1163 ASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIET 1222
Query: 213 YGMTPLLSASVTGHTNIVDFL-------THHAQTSKTERINALE----LLGATFVDKKRD 261
T L A G +V L H A+T T + A +G +DK D
Sbjct: 1223 NRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGAD 1282
Query: 262 L 262
+
Sbjct: 1283 V 1283
Score = 67.0 bits (162), Expect = 5e-11
Identities = 48/167 (28%), Positives = 81/167 (48%), Gaps = 12/167 (7%)
Query: 5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQC 64
TA+ A G+ +++ LL K+ E G TPL+ AA G+ ++ LL++
Sbjct: 1226 TALTLACFQGRAEVVSLLLDRKANVE-----HRAKTGLTPLMEAASGGYAEVGRVLLDK- 1279
Query: 65 SASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAAC 124
G VN L A+ GH K + L++ GA ++ +TPL A
Sbjct: 1280 ------GADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLAS 1333
Query: 125 FDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEK 171
GH ++V+ LV+ AD++ ++ T LM + KGH ++ QYL+++
Sbjct: 1334 NGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
Score = 60.5 bits (145), Expect = 5e-09
Identities = 38/125 (30%), Positives = 64/125 (51%), Gaps = 2/125 (1%)
Query: 111 NTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLE 170
+T + T L AC GH E+V L+ A +E ++ G T L+++ GH + + LL+
Sbjct: 1050 HTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLD 1109
Query: 171 KGADVNRKSVK-GNTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTN 228
KG D+ +S + +T L G +++ +LL A E ++ TPL A+ G+ N
Sbjct: 1110 KGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVN 1169
Query: 229 IVDFL 233
I+ L
Sbjct: 1170 IIKIL 1174
Score = 57.8 bits (138), Expect = 3e-08
Identities = 39/107 (36%), Positives = 54/107 (50%), Gaps = 8/107 (7%)
Query: 32 SSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAAS 91
+ L E G TPL+ AAR GHL V+FL+ + A++ + N D + A
Sbjct: 592 ADLEHESEGGRTPLMKAARAGHLCTVQFLISK-GANVN-RATANNDHTVVS------LAC 643
Query: 92 AAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEH 138
A GHL VV+ LL HGA + ST L A GH +V YL+++
Sbjct: 644 AGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
Score = 44.3 bits (103), Expect = 3e-04
Identities = 27/78 (34%), Positives = 42/78 (53%), Gaps = 13/78 (16%)
Query: 486 LHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMN 545
L +A DK G Y C+ +LI GA ++VR+ N+PL +A+ H D++
Sbjct: 1296 LTIAADK-----GHYKFCE--------LLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQ 1342
Query: 546 LLIKSGAHFDATNLHKQT 563
LL+++GA DA + K T
Sbjct: 1343 LLVQAGADVDAADNRKIT 1360
Score = 39.3 bits (90), Expect = 0.011
Identities = 19/56 (33%), Positives = 31/56 (55%)
Query: 503 CKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATN 558
C ++V +L++ GA VN+ SPL +AA H ++ LLI+ GA+ + N
Sbjct: 413 CMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVN 468
Score = 36.2 bits (82), Expect = 0.092
Identities = 86/385 (22%), Positives = 142/385 (36%), Gaps = 69/385 (17%)
Query: 183 NTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFLTH-----H 236
+TAL G +++ +L+ AK+E +D G TPL+ A+ GH +V+ L
Sbjct: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115
Query: 237 AQTSKTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAY 296
AQ+ +T+ L L + + DLL A K+ N+ SD T P +L +
Sbjct: 1116 AQSERTKD-TPLSLACSGGRQEVVDLLLARGANKEHRNV--SDYT-------PLSLAASG 1165
Query: 297 DYAKEVNSAEELEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKR 356
Y VN + L A+ + L I +L A +G+
Sbjct: 1166 GY---VNIIKILLNAGAEINSRTGSKLGISPLMLA-----------------AMNGHVPA 1205
Query: 357 CINLWKYALDMQ-QSNLDPLSPMTASSLLSFAELFSFMLQDRAKGLLGTTVTFDDLMGIL 415
L D+ Q + + +T + AE+ S +L +A LM
Sbjct: 1206 VKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAA 1265
Query: 416 CKSVLEIERAI----KQTQCPADPLQLNKALSIILHLICLLEKVPCTLEQDHFK--KQTI 469
E+ R + P P + AL+I ++ H+K + I
Sbjct: 1266 SGGYAEVGRVLLDKGADVNAPPVPSSRDTALTI-------------AADKGHYKFCELLI 1312
Query: 470 YRFLKLHPRGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDN 529
+R + R K +PL LA + V +L++ GADV+ D+
Sbjct: 1313 HRGAHIDVRNKKGNTPLWLASNGG-------------HFDVVQLLVQAGADVDAADNRKI 1359
Query: 530 SPLHIAALNNHPDIMNLLIKSGAHF 554
+PL A H ++ L+K F
Sbjct: 1360 TPLMSAFRKGHVKVVQYLVKEVNQF 1384
Score = 34.3 bits (77), Expect = 0.35
Identities = 28/83 (33%), Positives = 34/83 (40%), Gaps = 15/83 (18%)
Query: 478 RGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRD--SDDNSPLHIA 535
R K +PL A VGR +L++ GADVN S ++ L IA
Sbjct: 1253 RAKTGLTPLMEAASGGYAEVGR-------------VLLDKGADVNAPPVPSSRDTALTIA 1299
Query: 536 ALNNHPDIMNLLIKSGAHFDATN 558
A H LLI GAH D N
Sbjct: 1300 ADKGHYKFCELLIHRGAHIDVRN 1322
Score = 33.9 bits (76), Expect = 0.45
Identities = 24/81 (29%), Positives = 39/81 (48%), Gaps = 15/81 (18%)
Query: 478 RGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDN--SPLHIA 535
R ++++PL LA G Y + + IL+ GA++N R SPL +A
Sbjct: 1151 RNVSDYTPLSLAAS------GGY-------VNIIKILLNAGAEINSRTGSKLGISPLMLA 1197
Query: 536 ALNNHPDIMNLLIKSGAHFDA 556
A+N H + LL+ G+ +A
Sbjct: 1198 AMNGHVPAVKLLLDMGSDINA 1218
Score = 33.5 bits (75), Expect = 0.59
Identities = 20/61 (32%), Positives = 37/61 (60%), Gaps = 1/61 (1%)
Query: 508 LQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDA-TNLHKQTASD 566
+++ A+LIE GA++ + + +PL AA H +++ LL+ GA+ +A T ++TA
Sbjct: 451 VELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALT 510
Query: 567 L 567
L
Sbjct: 511 L 511
Score = 33.1 bits (74), Expect = 0.78
Identities = 25/100 (25%), Positives = 44/100 (44%), Gaps = 14/100 (14%)
Query: 469 IYRFLKLHPRGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVR-DSD 527
I R K+ R K F+PL LA + V IL++ G D+ + +
Sbjct: 1075 IARDAKIEHRDKKGFTPLILAATAG-------------HVGVVEILLDKGGDIEAQSERT 1121
Query: 528 DNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTASDL 567
++PL +A ++++LL+ GA+ + N+ T L
Sbjct: 1122 KDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSL 1161
Score = 30.8 bits (68), Expect = 3.8
Identities = 19/56 (33%), Positives = 30/56 (53%), Gaps = 3/56 (5%)
Query: 509 QVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTA 564
+V LI+ GAD+ + S +PL A+ H +++ L+ SGA+ AT TA
Sbjct: 519 EVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTA 571
Score = 30.4 bits (67), Expect = 5.0
Identities = 15/50 (30%), Positives = 26/50 (52%)
Query: 503 CKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGA 552
C L + L+E GAD + + ++ L A ++ H ++ LL+ SGA
Sbjct: 380 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGA 429
Score = 30.4 bits (67), Expect = 5.0
Identities = 13/48 (27%), Positives = 28/48 (58%)
Query: 508 LQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFD 555
L++ L+ GA+V+ + ++ L A N H D+ ++L+++GA +
Sbjct: 548 LELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 595
Score = 30.0 bits (66), Expect = 6.6
Identities = 16/56 (28%), Positives = 28/56 (50%)
Query: 508 LQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQT 563
L + +L+ ADVN + + N+ L A DI+ +L+ GA+ + N + T
Sbjct: 285 LDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHT 340
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 107 bits (267), Expect = 3e-23
Identities = 83/237 (35%), Positives = 118/237 (49%), Gaps = 28/237 (11%)
Query: 23 LASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQ------------------- 63
LA+ E +SL G TPL+ AAR GH +MV LL Q
Sbjct: 482 LAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLA 541
Query: 64 -CSASIEVGGSVNFDGETIE--GAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPL 120
C +EV + G IE + PL A+ GHL++V+ LL GA+V+ TT T T L
Sbjct: 542 CCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTAL 601
Query: 121 RAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSV 180
AC +GH ++ L++ ADLE + G T LM + GH Q+L+ KGA+VNR +
Sbjct: 602 TYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTA 661
Query: 181 KG-NTALHDCAESGSLDIMKMLLMYCAKME---KDGYGMTPLLSASVTGHTNIVDFL 233
+T L G L ++++LL + A KD G T L+ A+ GHT++V +L
Sbjct: 662 NNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKD--GSTMLIEAAKGGHTSVVCYL 716
Score = 98.2 bits (243), Expect = 2e-20
Identities = 74/227 (32%), Positives = 112/227 (49%), Gaps = 17/227 (7%)
Query: 10 AARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIE 69
A +G + + KLL E S+ G + L +A G+ ++ + LL
Sbjct: 241 ACSEGDVNAVRKLLI-----EGRSVNEHTEEGESLLCLACSAGYYELAQVLLAM------ 289
Query: 70 VGGSVNFDGETIEG-APPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGH 128
N + I+G PL AA+ GH+K+V+ LL H A VN + T +T L AC G+
Sbjct: 290 ---HANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGY 346
Query: 129 LEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVK-GNTALH 187
+++VK L+E A +E N +GHT LM + GH E+A+ LLE GA +N S + +AL
Sbjct: 347 VDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALT 406
Query: 188 DCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFL 233
G L++++ LL A E K T L+ A + GH + L
Sbjct: 407 LACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 453
Score = 96.7 bits (239), Expect = 6e-20
Identities = 80/274 (29%), Positives = 131/274 (47%), Gaps = 19/274 (6%)
Query: 10 AARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIE 69
A G+ ++ LLA + +E + TPL +AA G++++++ LL
Sbjct: 1157 ACSGGRQEVVELLLARGANKE-----HRNVSDYTPLSLAASGGYVNIIKILLN------- 1204
Query: 70 VGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTN-STPLRAACFDGH 128
G +N + G PL A+ GH V+ LL+ G+ +N TN +T L ACF G
Sbjct: 1205 AGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1264
Query: 129 LEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKG--NTAL 186
E+V L++ KA++E + G T LM + G+ E+ + LL+KGADVN V +TAL
Sbjct: 1265 TEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1324
Query: 187 HDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFLTHHAQTSKTERI 245
A+ G ++L+ A ++ ++ G TPL A+ GH ++V L
Sbjct: 1325 TIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADN 1384
Query: 246 NALELLGATFVDKKRDLLGALKYWKKAMNMRYSD 279
+ L A F ++ + ++Y K +N SD
Sbjct: 1385 RKITPLMAAF---RKGHVKVVRYLVKEVNQFPSD 1415
Score = 87.4 bits (215), Expect = 3e-17
Identities = 57/174 (32%), Positives = 95/174 (54%), Gaps = 5/174 (2%)
Query: 65 SASIEVGGSVNFDGETIEGAPP-LWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAA 123
SA + + +++ D +T L A A GH ++VQ+LL GAS+ + TPL A
Sbjct: 1064 SAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILA 1123
Query: 124 CFDGHLEIVKYLVEHKADLEV-SNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKG 182
GH+ +V+ L+++ AD+E S R T L ++C G +E+ + LL +GA+ ++V
Sbjct: 1124 ATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSD 1183
Query: 183 NTALHDCAESGSLDIMKMLLMYCAKMEK---DGYGMTPLLSASVTGHTNIVDFL 233
T L A G ++I+K+LL A++ G++PL+ A++ GHT V L
Sbjct: 1184 YTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLL 1237
Score = 87.4 bits (215), Expect = 3e-17
Identities = 69/229 (30%), Positives = 113/229 (49%), Gaps = 17/229 (7%)
Query: 5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQC 64
TA+ A G L+ LL E +S+ G TPL++AA GH+ +VE LL+
Sbjct: 1085 TALTLACAGGHEELVQTLL-----ERGASIEHRDKKGFTPLILAATAGHVGVVEILLDN- 1138
Query: 65 SASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAAC 124
A IE D PL A + G +VV+ LL GA+ + +++ TPL A
Sbjct: 1139 GADIEAQSERTKD-------TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAA 1191
Query: 125 FDGHLEIVKYLVEHKADL--EVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRK-SVK 181
G++ I+K L+ A++ ++ G + LM++ GH + LL+ G+D+N +
Sbjct: 1192 SGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETN 1251
Query: 182 GNTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNI 229
NTAL G +++ +LL A +E + G+TPL+ A+ G+ +
Sbjct: 1252 RNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEV 1300
Score = 85.9 bits (211), Expect = 1e-16
Identities = 66/231 (28%), Positives = 108/231 (46%), Gaps = 15/231 (6%)
Query: 5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQC 64
TA+ A G + ++ LL E +S+ NG TPL+ A GH+++ LLE
Sbjct: 336 TALTYACAGGYVDVVKVLL-----ESGASIEDHNENGHTPLMEAGSAGHVEVARLLLEN- 389
Query: 65 SASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAAC 124
G +N + + L A GHL++V+ LL GA + T T L AC
Sbjct: 390 ------GAGINTHSNEFKESA-LTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEAC 442
Query: 125 FDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNT 184
DGH+E+ + L++ A + + + L ++ GH E+A L+E+GA + + +G T
Sbjct: 443 MDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYT 502
Query: 185 ALHDCAESGSLDIMKMLLMYCAKM--EKDGYGMTPLLSASVTGHTNIVDFL 233
L + A G +++ +LL A + + + T L A G + DFL
Sbjct: 503 PLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFL 553
Score = 77.4 bits (189), Expect = 4e-14
Identities = 73/241 (30%), Positives = 114/241 (47%), Gaps = 25/241 (10%)
Query: 38 KTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLK 97
++N T L +A GH ++V+ LLE+ ASIE +G PL A+ AGH+
Sbjct: 1080 ESNHDTALTLACAGGHEELVQTLLER-GASIE--------HRDKKGFTPLILAATAGHVG 1130
Query: 98 VVQSLLNHGASVN-NTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMIS 156
VV+ LL++GA + + T TPL AC G E+V+ L+ A+ E N +T L ++
Sbjct: 1131 VVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLA 1190
Query: 157 CYKGHKEIAQYLLEKGADVNRK--SVKGNTALHDCAESGSLDIMKMLLMYCAKM--EKDG 212
G+ I + LL GA++N + S G + L A +G +K+LL + + + +
Sbjct: 1191 ASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIET 1250
Query: 213 YGMTPLLSASVTGHTNIVDFL-------THHAQTSKTERINALE----LLGATFVDKKRD 261
T L A G T +V L H A+T T + A +G +DK D
Sbjct: 1251 NRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGAD 1310
Query: 262 L 262
+
Sbjct: 1311 V 1311
Score = 67.4 bits (163), Expect = 4e-11
Identities = 48/167 (28%), Positives = 81/167 (48%), Gaps = 12/167 (7%)
Query: 5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQC 64
TA+ A G+ +++ LL K+ E G TPL+ AA G+ ++ LL++
Sbjct: 1254 TALTLACFQGRTEVVSLLLDRKANVE-----HRAKTGLTPLMEAASGGYAEVGRVLLDK- 1307
Query: 65 SASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAAC 124
G VN L A+ GH K + L+ GA ++ +TPL A
Sbjct: 1308 ------GADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAA 1361
Query: 125 FDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEK 171
GHL++V+ LV+ AD++ ++ T LM + KGH ++ +YL+++
Sbjct: 1362 NGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1408
Score = 60.8 bits (146), Expect = 3e-09
Identities = 47/147 (31%), Positives = 68/147 (46%), Gaps = 21/147 (14%)
Query: 1 MDLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEK----------TNGATPLLMAAR 50
+D K V + A+ G L+ AS EV ++ +K ++ T L +AA
Sbjct: 1272 LDRKANVEHRAKTGLTPLMEA--ASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD 1329
Query: 51 YGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVN 110
GH E L +G + D +G PLW A+ GHL VVQ L+ GA V+
Sbjct: 1330 KGHYKFCELL---------IGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVD 1380
Query: 111 NTTLTNSTPLRAACFDGHLEIVKYLVE 137
TPL AA GH+++V+YLV+
Sbjct: 1381 AADNRKITPLMAAFRKGHVKVVRYLVK 1407
Score = 57.4 bits (137), Expect = 4e-08
Identities = 40/111 (36%), Positives = 55/111 (49%), Gaps = 8/111 (7%)
Query: 32 SSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAAS 91
+ L E G TPL+ AAR GH+ V+FL+ S V + + T+ L A
Sbjct: 621 ADLEHESEGGRTPLMKAARAGHVCTVQFLI---SKGANVNRTTANNDHTV-----LSLAC 672
Query: 92 AAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADL 142
A GHL VV+ LL HGA + ST L A GH +V YL+++ +L
Sbjct: 673 AGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNL 723
Score = 55.1 bits (131), Expect = 2e-07
Identities = 37/128 (28%), Positives = 63/128 (49%), Gaps = 2/128 (1%)
Query: 108 SVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQY 167
S N +++ L AC +G + V+ L+ + G + L ++C G+ E+AQ
Sbjct: 226 STANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQV 285
Query: 168 LLEKGADVNRKSVKGN-TALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTG 225
LL A+V + +KG+ T L A G + I+K+LL + A + + G T L A G
Sbjct: 286 LLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGG 345
Query: 226 HTNIVDFL 233
+ ++V L
Sbjct: 346 YVDVVKVL 353
Score = 45.4 bits (106), Expect = 2e-04
Identities = 31/100 (31%), Positives = 52/100 (52%), Gaps = 16/100 (16%)
Query: 486 LHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMN 545
L +A DK G Y C+ +LI GA ++VR+ N+PL +AA H D++
Sbjct: 1324 LTIAADK-----GHYKFCE--------LLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQ 1370
Query: 546 LLIKSGAHFDATNLHKQT---ASDLLDEKEIAKNLIQPIN 582
LL+++GA DA + K T A+ ++ + L++ +N
Sbjct: 1371 LLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVN 1410
Score = 38.5 bits (88), Expect = 0.018
Identities = 19/56 (33%), Positives = 30/56 (53%)
Query: 503 CKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATN 558
C ++V +L++ GA VN+ SPL +AA H ++ LLI+ GA + N
Sbjct: 442 CMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVN 497
Score = 33.9 bits (76), Expect = 0.45
Identities = 24/81 (29%), Positives = 39/81 (48%), Gaps = 15/81 (18%)
Query: 478 RGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDN--SPLHIA 535
R ++++PL LA G Y + + IL+ GA++N R SPL +A
Sbjct: 1179 RNVSDYTPLSLAAS------GGY-------VNIIKILLNAGAEINSRTGSKLGISPLMLA 1225
Query: 536 ALNNHPDIMNLLIKSGAHFDA 556
A+N H + LL+ G+ +A
Sbjct: 1226 AMNGHTAAVKLLLDMGSDINA 1246
Score = 33.9 bits (76), Expect = 0.45
Identities = 28/83 (33%), Positives = 34/83 (40%), Gaps = 15/83 (18%)
Query: 478 RGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRD--SDDNSPLHIA 535
R K +PL A VGR +L++ GADVN S ++ L IA
Sbjct: 1281 RAKTGLTPLMEAASGGYAEVGR-------------VLLDKGADVNAPPVPSSRDTALTIA 1327
Query: 536 ALNNHPDIMNLLIKSGAHFDATN 558
A H LLI GAH D N
Sbjct: 1328 ADKGHYKFCELLIGRGAHIDVRN 1350
Score = 33.5 bits (75), Expect = 0.59
Identities = 16/56 (28%), Positives = 31/56 (55%)
Query: 508 LQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQT 563
+++ +L+ ADVN + S N+ L A + D++ +L++SGA + N + T
Sbjct: 314 VKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHT 369
Score = 33.5 bits (75), Expect = 0.59
Identities = 27/118 (22%), Positives = 51/118 (43%), Gaps = 15/118 (12%)
Query: 460 EQDHFK--KQTIYRFLKLHPRGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIEC 517
++ H+K + I R + R K +PL LA + L V +L++
Sbjct: 1329 DKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGG-------------HLDVVQLLVQA 1375
Query: 518 GADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTASDLLDEKEIAK 575
GADV+ D+ +PL A H ++ L+K F + + + + + D++ + K
Sbjct: 1376 GADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKK 1433
Score = 32.7 bits (73), Expect = 1.0
Identities = 20/73 (27%), Positives = 37/73 (50%), Gaps = 8/73 (10%)
Query: 496 CVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFD 555
C G Y + V +L+E GA + + + ++PL A H ++ LL+++GA +
Sbjct: 342 CAGGY-------VDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGIN 394
Query: 556 A-TNLHKQTASDL 567
+N K++A L
Sbjct: 395 THSNEFKESALTL 407
Score = 32.7 bits (73), Expect = 1.0
Identities = 20/61 (32%), Positives = 36/61 (59%), Gaps = 1/61 (1%)
Query: 508 LQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDA-TNLHKQTASD 566
+++ A+LIE GA + + + +PL AA H +++ LL+ GA+ +A T ++TA
Sbjct: 480 VELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALT 539
Query: 567 L 567
L
Sbjct: 540 L 540
Score = 32.7 bits (73), Expect = 1.0
Identities = 15/48 (31%), Positives = 27/48 (56%)
Query: 509 QVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDA 556
++ L+E GA + RD +PL +AA H ++ +L+ +GA +A
Sbjct: 1097 ELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144
Score = 32.7 bits (73), Expect = 1.0
Identities = 18/66 (27%), Positives = 34/66 (51%)
Query: 503 CKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQ 562
C +V +L+ GA+ R+ D +PL +AA + +I+ +L+ +GA ++ K
Sbjct: 1158 CSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKL 1217
Query: 563 TASDLL 568
S L+
Sbjct: 1218 GISPLM 1223
Score = 32.3 bits (72), Expect = 1.3
Identities = 20/57 (35%), Positives = 31/57 (54%), Gaps = 3/57 (5%)
Query: 508 LQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTA 564
L+V LI+ GAD+ + S +PL AA H +++ L+ +GA+ AT TA
Sbjct: 547 LEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA 600
Score = 32.3 bits (72), Expect = 1.3
Identities = 25/112 (22%), Positives = 46/112 (41%), Gaps = 14/112 (12%)
Query: 457 CTLEQDHFKKQTIYRFLKLHPRGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIE 516
C + + + R + R K F+PL LA + V IL++
Sbjct: 1091 CAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAG-------------HVGVVEILLD 1137
Query: 517 CGADVNVR-DSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTASDL 567
GAD+ + + ++PL +A +++ LL+ GA+ + N+ T L
Sbjct: 1138 NGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSL 1189
Score = 31.2 bits (69), Expect = 2.9
Identities = 15/50 (30%), Positives = 27/50 (54%)
Query: 503 CKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGA 552
C L++ L+E GAD + + ++ L A ++ H ++ LL+ SGA
Sbjct: 409 CYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGA 458
Score = 30.8 bits (68), Expect = 3.8
Identities = 13/48 (27%), Positives = 28/48 (58%)
Query: 508 LQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFD 555
L++ L+ GA+V+ + ++ L A N H D+ ++L+++GA +
Sbjct: 577 LELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 624
Score = 29.6 bits (65), Expect = 8.6
Identities = 16/55 (29%), Positives = 25/55 (45%)
Query: 503 CKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDAT 557
C+ V +L++ GAD+ +PL AA H + LI GA+ + T
Sbjct: 605 CENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRT 659
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 107 bits (267), Expect = 3e-23
Identities = 83/237 (35%), Positives = 118/237 (49%), Gaps = 28/237 (11%)
Query: 23 LASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQ------------------- 63
LA+ E +SL G TPL+ AAR GH +MV LL Q
Sbjct: 482 LAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLA 541
Query: 64 -CSASIEVGGSVNFDGETIE--GAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPL 120
C +EV + G IE + PL A+ GHL++V+ LL GA+V+ TT T T L
Sbjct: 542 CCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTAL 601
Query: 121 RAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSV 180
AC +GH ++ L++ ADLE + G T LM + GH Q+L+ KGA+VNR +
Sbjct: 602 TYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTA 661
Query: 181 KG-NTALHDCAESGSLDIMKMLLMYCAKME---KDGYGMTPLLSASVTGHTNIVDFL 233
+T L G L ++++LL + A KD G T L+ A+ GHT++V +L
Sbjct: 662 NNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKD--GSTMLIEAAKGGHTSVVCYL 716
Score = 98.2 bits (243), Expect = 2e-20
Identities = 74/227 (32%), Positives = 112/227 (49%), Gaps = 17/227 (7%)
Query: 10 AARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIE 69
A +G + + KLL E S+ G + L +A G+ ++ + LL
Sbjct: 241 ACSEGDVNAVRKLLI-----EGRSVNEHTEEGESLLCLACSAGYYELAQVLLAM------ 289
Query: 70 VGGSVNFDGETIEG-APPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGH 128
N + I+G PL AA+ GH+K+V+ LL H A VN + T +T L AC G+
Sbjct: 290 ---HANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGY 346
Query: 129 LEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVK-GNTALH 187
+++VK L+E A +E N +GHT LM + GH E+A+ LLE GA +N S + +AL
Sbjct: 347 VDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALT 406
Query: 188 DCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFL 233
G L++++ LL A E K T L+ A + GH + L
Sbjct: 407 LACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 453
Score = 96.7 bits (239), Expect = 6e-20
Identities = 80/274 (29%), Positives = 131/274 (47%), Gaps = 19/274 (6%)
Query: 10 AARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIE 69
A G+ ++ LLA + +E + TPL +AA G++++++ LL
Sbjct: 906 ACSGGRQEVVELLLARGANKE-----HRNVSDYTPLSLAASGGYVNIIKILLN------- 953
Query: 70 VGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTN-STPLRAACFDGH 128
G +N + G PL A+ GH V+ LL+ G+ +N TN +T L ACF G
Sbjct: 954 AGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1013
Query: 129 LEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKG--NTAL 186
E+V L++ KA++E + G T LM + G+ E+ + LL+KGADVN V +TAL
Sbjct: 1014 TEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1073
Query: 187 HDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFLTHHAQTSKTERI 245
A+ G ++L+ A ++ ++ G TPL A+ GH ++V L
Sbjct: 1074 TIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADN 1133
Query: 246 NALELLGATFVDKKRDLLGALKYWKKAMNMRYSD 279
+ L A F ++ + ++Y K +N SD
Sbjct: 1134 RKITPLMAAF---RKGHVKVVRYLVKEVNQFPSD 1164
Score = 87.4 bits (215), Expect = 3e-17
Identities = 57/174 (32%), Positives = 95/174 (54%), Gaps = 5/174 (2%)
Query: 65 SASIEVGGSVNFDGETIEGAPP-LWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAA 123
SA + + +++ D +T L A A GH ++VQ+LL GAS+ + TPL A
Sbjct: 813 SAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILA 872
Query: 124 CFDGHLEIVKYLVEHKADLEV-SNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKG 182
GH+ +V+ L+++ AD+E S R T L ++C G +E+ + LL +GA+ ++V
Sbjct: 873 ATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSD 932
Query: 183 NTALHDCAESGSLDIMKMLLMYCAKMEK---DGYGMTPLLSASVTGHTNIVDFL 233
T L A G ++I+K+LL A++ G++PL+ A++ GHT V L
Sbjct: 933 YTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLL 986
Score = 87.4 bits (215), Expect = 3e-17
Identities = 69/229 (30%), Positives = 113/229 (49%), Gaps = 17/229 (7%)
Query: 5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQC 64
TA+ A G L+ LL E +S+ G TPL++AA GH+ +VE LL+
Sbjct: 834 TALTLACAGGHEELVQTLL-----ERGASIEHRDKKGFTPLILAATAGHVGVVEILLDN- 887
Query: 65 SASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAAC 124
A IE D PL A + G +VV+ LL GA+ + +++ TPL A
Sbjct: 888 GADIEAQSERTKD-------TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAA 940
Query: 125 FDGHLEIVKYLVEHKADL--EVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRK-SVK 181
G++ I+K L+ A++ ++ G + LM++ GH + LL+ G+D+N +
Sbjct: 941 SGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETN 1000
Query: 182 GNTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNI 229
NTAL G +++ +LL A +E + G+TPL+ A+ G+ +
Sbjct: 1001 RNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEV 1049
Score = 85.9 bits (211), Expect = 1e-16
Identities = 66/231 (28%), Positives = 108/231 (46%), Gaps = 15/231 (6%)
Query: 5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQC 64
TA+ A G + ++ LL E +S+ NG TPL+ A GH+++ LLE
Sbjct: 336 TALTYACAGGYVDVVKVLL-----ESGASIEDHNENGHTPLMEAGSAGHVEVARLLLEN- 389
Query: 65 SASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAAC 124
G +N + + L A GHL++V+ LL GA + T T L AC
Sbjct: 390 ------GAGINTHSNEFKESA-LTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEAC 442
Query: 125 FDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNT 184
DGH+E+ + L++ A + + + L ++ GH E+A L+E+GA + + +G T
Sbjct: 443 MDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYT 502
Query: 185 ALHDCAESGSLDIMKMLLMYCAKM--EKDGYGMTPLLSASVTGHTNIVDFL 233
L + A G +++ +LL A + + + T L A G + DFL
Sbjct: 503 PLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFL 553
Score = 77.4 bits (189), Expect = 4e-14
Identities = 73/241 (30%), Positives = 114/241 (47%), Gaps = 25/241 (10%)
Query: 38 KTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLK 97
++N T L +A GH ++V+ LLE+ ASIE +G PL A+ AGH+
Sbjct: 829 ESNHDTALTLACAGGHEELVQTLLER-GASIE--------HRDKKGFTPLILAATAGHVG 879
Query: 98 VVQSLLNHGASVN-NTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMIS 156
VV+ LL++GA + + T TPL AC G E+V+ L+ A+ E N +T L ++
Sbjct: 880 VVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLA 939
Query: 157 CYKGHKEIAQYLLEKGADVNRK--SVKGNTALHDCAESGSLDIMKMLLMYCAKM--EKDG 212
G+ I + LL GA++N + S G + L A +G +K+LL + + + +
Sbjct: 940 ASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIET 999
Query: 213 YGMTPLLSASVTGHTNIVDFL-------THHAQTSKTERINALE----LLGATFVDKKRD 261
T L A G T +V L H A+T T + A +G +DK D
Sbjct: 1000 NRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGAD 1059
Query: 262 L 262
+
Sbjct: 1060 V 1060
Score = 67.4 bits (163), Expect = 4e-11
Identities = 48/167 (28%), Positives = 81/167 (48%), Gaps = 12/167 (7%)
Query: 5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQC 64
TA+ A G+ +++ LL K+ E G TPL+ AA G+ ++ LL++
Sbjct: 1003 TALTLACFQGRTEVVSLLLDRKANVE-----HRAKTGLTPLMEAASGGYAEVGRVLLDK- 1056
Query: 65 SASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAAC 124
G VN L A+ GH K + L+ GA ++ +TPL A
Sbjct: 1057 ------GADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAA 1110
Query: 125 FDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEK 171
GHL++V+ LV+ AD++ ++ T LM + KGH ++ +YL+++
Sbjct: 1111 NGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1157
Score = 60.8 bits (146), Expect = 3e-09
Identities = 47/147 (31%), Positives = 68/147 (46%), Gaps = 21/147 (14%)
Query: 1 MDLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEK----------TNGATPLLMAAR 50
+D K V + A+ G L+ AS EV ++ +K ++ T L +AA
Sbjct: 1021 LDRKANVEHRAKTGLTPLMEA--ASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD 1078
Query: 51 YGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVN 110
GH E L +G + D +G PLW A+ GHL VVQ L+ GA V+
Sbjct: 1079 KGHYKFCELL---------IGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVD 1129
Query: 111 NTTLTNSTPLRAACFDGHLEIVKYLVE 137
TPL AA GH+++V+YLV+
Sbjct: 1130 AADNRKITPLMAAFRKGHVKVVRYLVK 1156
Score = 57.4 bits (137), Expect = 4e-08
Identities = 40/111 (36%), Positives = 55/111 (49%), Gaps = 8/111 (7%)
Query: 32 SSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAAS 91
+ L E G TPL+ AAR GH+ V+FL+ S V + + T+ L A
Sbjct: 621 ADLEHESEGGRTPLMKAARAGHVCTVQFLI---SKGANVNRTTANNDHTV-----LSLAC 672
Query: 92 AAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADL 142
A GHL VV+ LL HGA + ST L A GH +V YL+++ +L
Sbjct: 673 AGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNL 723
Score = 55.1 bits (131), Expect = 2e-07
Identities = 37/128 (28%), Positives = 63/128 (49%), Gaps = 2/128 (1%)
Query: 108 SVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQY 167
S N +++ L AC +G + V+ L+ + G + L ++C G+ E+AQ
Sbjct: 226 STANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQV 285
Query: 168 LLEKGADVNRKSVKGN-TALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTG 225
LL A+V + +KG+ T L A G + I+K+LL + A + + G T L A G
Sbjct: 286 LLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGG 345
Query: 226 HTNIVDFL 233
+ ++V L
Sbjct: 346 YVDVVKVL 353
Score = 45.4 bits (106), Expect = 2e-04
Identities = 31/100 (31%), Positives = 52/100 (52%), Gaps = 16/100 (16%)
Query: 486 LHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMN 545
L +A DK G Y C+ +LI GA ++VR+ N+PL +AA H D++
Sbjct: 1073 LTIAADK-----GHYKFCE--------LLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQ 1119
Query: 546 LLIKSGAHFDATNLHKQT---ASDLLDEKEIAKNLIQPIN 582
LL+++GA DA + K T A+ ++ + L++ +N
Sbjct: 1120 LLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVN 1159
Score = 38.5 bits (88), Expect = 0.018
Identities = 19/56 (33%), Positives = 30/56 (53%)
Query: 503 CKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATN 558
C ++V +L++ GA VN+ SPL +AA H ++ LLI+ GA + N
Sbjct: 442 CMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVN 497
Score = 33.9 bits (76), Expect = 0.45
Identities = 24/81 (29%), Positives = 39/81 (48%), Gaps = 15/81 (18%)
Query: 478 RGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDN--SPLHIA 535
R ++++PL LA G Y + + IL+ GA++N R SPL +A
Sbjct: 928 RNVSDYTPLSLAAS------GGY-------VNIIKILLNAGAEINSRTGSKLGISPLMLA 974
Query: 536 ALNNHPDIMNLLIKSGAHFDA 556
A+N H + LL+ G+ +A
Sbjct: 975 AMNGHTAAVKLLLDMGSDINA 995
Score = 33.9 bits (76), Expect = 0.45
Identities = 28/83 (33%), Positives = 34/83 (40%), Gaps = 15/83 (18%)
Query: 478 RGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRD--SDDNSPLHIA 535
R K +PL A VGR +L++ GADVN S ++ L IA
Sbjct: 1030 RAKTGLTPLMEAASGGYAEVGR-------------VLLDKGADVNAPPVPSSRDTALTIA 1076
Query: 536 ALNNHPDIMNLLIKSGAHFDATN 558
A H LLI GAH D N
Sbjct: 1077 ADKGHYKFCELLIGRGAHIDVRN 1099
Score = 33.5 bits (75), Expect = 0.59
Identities = 16/56 (28%), Positives = 31/56 (55%)
Query: 508 LQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQT 563
+++ +L+ ADVN + S N+ L A + D++ +L++SGA + N + T
Sbjct: 314 VKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHT 369
Score = 33.5 bits (75), Expect = 0.59
Identities = 27/118 (22%), Positives = 51/118 (43%), Gaps = 15/118 (12%)
Query: 460 EQDHFK--KQTIYRFLKLHPRGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIEC 517
++ H+K + I R + R K +PL LA + L V +L++
Sbjct: 1078 DKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGG-------------HLDVVQLLVQA 1124
Query: 518 GADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTASDLLDEKEIAK 575
GADV+ D+ +PL A H ++ L+K F + + + + + D++ + K
Sbjct: 1125 GADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKK 1182
Score = 32.7 bits (73), Expect = 1.0
Identities = 20/73 (27%), Positives = 37/73 (50%), Gaps = 8/73 (10%)
Query: 496 CVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFD 555
C G Y + V +L+E GA + + + ++PL A H ++ LL+++GA +
Sbjct: 342 CAGGY-------VDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGIN 394
Query: 556 A-TNLHKQTASDL 567
+N K++A L
Sbjct: 395 THSNEFKESALTL 407
Score = 32.7 bits (73), Expect = 1.0
Identities = 20/61 (32%), Positives = 36/61 (59%), Gaps = 1/61 (1%)
Query: 508 LQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDA-TNLHKQTASD 566
+++ A+LIE GA + + + +PL AA H +++ LL+ GA+ +A T ++TA
Sbjct: 480 VELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALT 539
Query: 567 L 567
L
Sbjct: 540 L 540
Score = 32.7 bits (73), Expect = 1.0
Identities = 15/48 (31%), Positives = 27/48 (56%)
Query: 509 QVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDA 556
++ L+E GA + RD +PL +AA H ++ +L+ +GA +A
Sbjct: 846 ELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 893
Score = 32.7 bits (73), Expect = 1.0
Identities = 18/66 (27%), Positives = 34/66 (51%)
Query: 503 CKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQ 562
C +V +L+ GA+ R+ D +PL +AA + +I+ +L+ +GA ++ K
Sbjct: 907 CSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKL 966
Query: 563 TASDLL 568
S L+
Sbjct: 967 GISPLM 972
Score = 32.3 bits (72), Expect = 1.3
Identities = 20/57 (35%), Positives = 31/57 (54%), Gaps = 3/57 (5%)
Query: 508 LQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTA 564
L+V LI+ GAD+ + S +PL AA H +++ L+ +GA+ AT TA
Sbjct: 547 LEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA 600
Score = 32.3 bits (72), Expect = 1.3
Identities = 25/112 (22%), Positives = 46/112 (41%), Gaps = 14/112 (12%)
Query: 457 CTLEQDHFKKQTIYRFLKLHPRGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIE 516
C + + + R + R K F+PL LA + V IL++
Sbjct: 840 CAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAG-------------HVGVVEILLD 886
Query: 517 CGADVNVR-DSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTASDL 567
GAD+ + + ++PL +A +++ LL+ GA+ + N+ T L
Sbjct: 887 NGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSL 938
Score = 31.2 bits (69), Expect = 2.9
Identities = 15/50 (30%), Positives = 27/50 (54%)
Query: 503 CKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGA 552
C L++ L+E GAD + + ++ L A ++ H ++ LL+ SGA
Sbjct: 409 CYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGA 458
Score = 30.8 bits (68), Expect = 3.8
Identities = 13/48 (27%), Positives = 28/48 (58%)
Query: 508 LQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFD 555
L++ L+ GA+V+ + ++ L A N H D+ ++L+++GA +
Sbjct: 577 LELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 624
Score = 29.6 bits (65), Expect = 8.6
Identities = 16/55 (29%), Positives = 25/55 (45%)
Query: 503 CKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDAT 557
C+ V +L++ GAD+ +PL AA H + LI GA+ + T
Sbjct: 605 CENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRT 659
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 100 bits (248), Expect = 5e-21
Identities = 75/226 (33%), Positives = 114/226 (50%), Gaps = 15/226 (6%)
Query: 10 AARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIE 69
A DG + + KLL +E S+ G + L +A G+ ++ + LL A++E
Sbjct: 212 ACSDGDVNAVRKLL-----DEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAM-HANVE 265
Query: 70 VGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHL 129
G+ PL AAS+ G+L +V+ LL H A VN+ + T +T L AC G +
Sbjct: 266 DRGNKG-------DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFV 318
Query: 130 EIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVK-GNTALHD 188
+IVK L+ A++E N +GHT LM + GH E+A+ LL+ GA +N S + +AL
Sbjct: 319 DIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTL 378
Query: 189 CAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFL 233
G LD+++ LL A E K T L+ A + GH + L
Sbjct: 379 ACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 424
Score = 97.8 bits (242), Expect = 3e-20
Identities = 61/194 (31%), Positives = 103/194 (53%), Gaps = 13/194 (6%)
Query: 43 TPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSL 102
TPL+ A+ G+LD+V+ LL + + ++ G L A A G + +V+ L
Sbjct: 274 TPLMAASSGGYLDIVKLLLLH---------DADVNSQSATGNTALTYACAGGFVDIVKVL 324
Query: 103 LNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEV-SNRHGHTCLMISCYKGH 161
LN GA++ + TPL A GH+E+ + L++H A + SN + L ++CYKGH
Sbjct: 325 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH 384
Query: 162 KEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAK--MEKDGYGMTPLL 219
++ ++LLE GAD K+ + +TAL + G +++ ++LL A+ M D + +PL
Sbjct: 385 LDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF-ESPLT 443
Query: 220 SASVTGHTNIVDFL 233
A+ GH + L
Sbjct: 444 LAACGGHVELAALL 457
Score = 94.0 bits (232), Expect = 4e-19
Identities = 66/210 (31%), Positives = 107/210 (50%), Gaps = 18/210 (8%)
Query: 2 DLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLL 61
++ TA+ A DG + + LL S ++ + + E +PL +AA GH+++ L+
Sbjct: 404 EMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE-----SPLTLAACGGHVELAALLI 458
Query: 62 EQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVN-NTTLTNSTPL 120
E+ N + EG PL A+ GH ++V LL GA++N T T T L
Sbjct: 459 ER---------GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETAL 509
Query: 121 RAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSV 180
AC G E+ +L++ AD+E+ T LM + +GH E+ +YLL GA+V+ +
Sbjct: 510 TLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTA 566
Query: 181 KGNTALHDCAESGSLDIMKMLLMYCAKMEK 210
G+TAL E+G D+ +LL A ++K
Sbjct: 567 TGDTALTYACENGHTDVADVLLQAGADLDK 596
Score = 91.3 bits (225), Expect = 2e-18
Identities = 65/190 (34%), Positives = 97/190 (51%), Gaps = 12/190 (6%)
Query: 45 LLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLN 104
L +A GHLDMV FLLE + + +T E L A GH++V + LL+
Sbjct: 376 LTLACYKGHLDMVRFLLE---------AGADQEHKTDEMHTALMEACMDGHVEVARLLLD 426
Query: 105 HGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEI 164
GA VN + +PL A GH+E+ L+E A+LE N G+T LM + +GH+E+
Sbjct: 427 SGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEM 486
Query: 165 AQYLLEKGADVNRKSVK-GNTALHDCAESGSLDIMKMLLMYCAKMEKDGYGMTPLLSASV 223
LL +GA++N ++ + TAL G ++ L+ A +E TPL+ AS
Sbjct: 487 VALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELG--CSTPLMEASQ 544
Query: 224 TGHTNIVDFL 233
GH +V +L
Sbjct: 545 EGHLELVKYL 554
Score = 82.0 bits (201), Expect = 1e-15
Identities = 55/156 (35%), Positives = 80/156 (51%), Gaps = 11/156 (7%)
Query: 23 LASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIE 82
LA+ E ++L G TPL+ AAR GH +MV LL Q G ++N E +
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ-------GANINAQTEETQ 505
Query: 83 GAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADL 142
L A G +V L+ GA + L STPL A +GHLE+VKYL+ A++
Sbjct: 506 ETA-LTLACCGGFSEVADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLLASGANV 561
Query: 143 EVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRK 178
+ G T L +C GH ++A LL+ GAD++++
Sbjct: 562 HATTATGDTALTYACENGHTDVADVLLQAGADLDKQ 597
Score = 77.8 bits (190), Expect = 3e-14
Identities = 53/149 (35%), Positives = 76/149 (51%), Gaps = 2/149 (1%)
Query: 90 ASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHG 149
A + G + V+ LL+ G SVN T + L AC G+ E+ + L+ A++E G
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 150 H-TCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKM 208
T LM + G+ +I + LL ADVN +S GNTAL G +DI+K+LL A +
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331
Query: 209 EKDGY-GMTPLLSASVTGHTNIVDFLTHH 236
E G TPL+ A+ GH + L H
Sbjct: 332 EDHNENGHTPLMEAASAGHVEVARVLLDH 360
Score = 39.3 bits (90), Expect = 0.011
Identities = 19/56 (33%), Positives = 31/56 (55%)
Query: 503 CKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATN 558
C ++V +L++ GA VN+ SPL +AA H ++ LLI+ GA+ + N
Sbjct: 413 CMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVN 468
Score = 33.5 bits (75), Expect = 0.59
Identities = 20/61 (32%), Positives = 37/61 (60%), Gaps = 1/61 (1%)
Query: 508 LQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDA-TNLHKQTASD 566
+++ A+LIE GA++ + + +PL AA H +++ LL+ GA+ +A T ++TA
Sbjct: 451 VELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALT 510
Query: 567 L 567
L
Sbjct: 511 L 511
Score = 32.0 bits (71), Expect = 1.7
Identities = 14/48 (29%), Positives = 28/48 (58%)
Query: 508 LQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFD 555
L++ L+ GA+V+ + ++ L A N H D+ ++L+++GA D
Sbjct: 548 LELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 595
Score = 30.8 bits (68), Expect = 3.8
Identities = 19/56 (33%), Positives = 30/56 (53%), Gaps = 3/56 (5%)
Query: 509 QVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTA 564
+V LI+ GAD+ + S +PL A+ H +++ L+ SGA+ AT TA
Sbjct: 519 EVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTA 571
Score = 30.4 bits (67), Expect = 5.0
Identities = 15/50 (30%), Positives = 26/50 (52%)
Query: 503 CKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGA 552
C L + L+E GAD + + ++ L A ++ H ++ LL+ SGA
Sbjct: 380 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGA 429
Score = 30.0 bits (66), Expect = 6.6
Identities = 16/56 (28%), Positives = 28/56 (50%)
Query: 508 LQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQT 563
L + +L+ ADVN + + N+ L A DI+ +L+ GA+ + N + T
Sbjct: 285 LDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHT 340
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 100 bits (248), Expect = 5e-21
Identities = 75/226 (33%), Positives = 114/226 (50%), Gaps = 15/226 (6%)
Query: 10 AARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIE 69
A DG + + KLL +E S+ G + L +A G+ ++ + LL A++E
Sbjct: 201 ACSDGDVNAVRKLL-----DEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAM-HANVE 254
Query: 70 VGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHL 129
G+ PL AAS+ G+L +V+ LL H A VN+ + T +T L AC G +
Sbjct: 255 DRGNKG-------DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFV 307
Query: 130 EIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVK-GNTALHD 188
+IVK L+ A++E N +GHT LM + GH E+A+ LL+ GA +N S + +AL
Sbjct: 308 DIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTL 367
Query: 189 CAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFL 233
G LD+++ LL A E K T L+ A + GH + L
Sbjct: 368 ACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 413
Score = 97.8 bits (242), Expect = 3e-20
Identities = 61/194 (31%), Positives = 103/194 (53%), Gaps = 13/194 (6%)
Query: 43 TPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSL 102
TPL+ A+ G+LD+V+ LL + + ++ G L A A G + +V+ L
Sbjct: 263 TPLMAASSGGYLDIVKLLLLH---------DADVNSQSATGNTALTYACAGGFVDIVKVL 313
Query: 103 LNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEV-SNRHGHTCLMISCYKGH 161
LN GA++ + TPL A GH+E+ + L++H A + SN + L ++CYKGH
Sbjct: 314 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH 373
Query: 162 KEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAK--MEKDGYGMTPLL 219
++ ++LLE GAD K+ + +TAL + G +++ ++LL A+ M D + +PL
Sbjct: 374 LDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF-ESPLT 432
Query: 220 SASVTGHTNIVDFL 233
A+ GH + L
Sbjct: 433 LAACGGHVELAALL 446
Score = 94.0 bits (232), Expect = 4e-19
Identities = 66/210 (31%), Positives = 107/210 (50%), Gaps = 18/210 (8%)
Query: 2 DLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLL 61
++ TA+ A DG + + LL S ++ + + E +PL +AA GH+++ L+
Sbjct: 393 EMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE-----SPLTLAACGGHVELAALLI 447
Query: 62 EQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVN-NTTLTNSTPL 120
E+ N + EG PL A+ GH ++V LL GA++N T T T L
Sbjct: 448 ER---------GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETAL 498
Query: 121 RAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSV 180
AC G E+ +L++ AD+E+ T LM + +GH E+ +YLL GA+V+ +
Sbjct: 499 TLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTA 555
Query: 181 KGNTALHDCAESGSLDIMKMLLMYCAKMEK 210
G+TAL E+G D+ +LL A ++K
Sbjct: 556 TGDTALTYACENGHTDVADVLLQAGADLDK 585
Score = 91.3 bits (225), Expect = 2e-18
Identities = 65/190 (34%), Positives = 97/190 (51%), Gaps = 12/190 (6%)
Query: 45 LLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLN 104
L +A GHLDMV FLLE + + +T E L A GH++V + LL+
Sbjct: 365 LTLACYKGHLDMVRFLLE---------AGADQEHKTDEMHTALMEACMDGHVEVARLLLD 415
Query: 105 HGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEI 164
GA VN + +PL A GH+E+ L+E A+LE N G+T LM + +GH+E+
Sbjct: 416 SGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEM 475
Query: 165 AQYLLEKGADVNRKSVK-GNTALHDCAESGSLDIMKMLLMYCAKMEKDGYGMTPLLSASV 223
LL +GA++N ++ + TAL G ++ L+ A +E TPL+ AS
Sbjct: 476 VALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELG--CSTPLMEASQ 533
Query: 224 TGHTNIVDFL 233
GH +V +L
Sbjct: 534 EGHLELVKYL 543
Score = 82.0 bits (201), Expect = 1e-15
Identities = 55/156 (35%), Positives = 80/156 (51%), Gaps = 11/156 (7%)
Query: 23 LASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIE 82
LA+ E ++L G TPL+ AAR GH +MV LL Q G ++N E +
Sbjct: 442 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ-------GANINAQTEETQ 494
Query: 83 GAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADL 142
L A G +V L+ GA + L STPL A +GHLE+VKYL+ A++
Sbjct: 495 ETA-LTLACCGGFSEVADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLLASGANV 550
Query: 143 EVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRK 178
+ G T L +C GH ++A LL+ GAD++++
Sbjct: 551 HATTATGDTALTYACENGHTDVADVLLQAGADLDKQ 586
Score = 77.8 bits (190), Expect = 3e-14
Identities = 53/149 (35%), Positives = 76/149 (51%), Gaps = 2/149 (1%)
Query: 90 ASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHG 149
A + G + V+ LL+ G SVN T + L AC G+ E+ + L+ A++E G
Sbjct: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
Query: 150 H-TCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKM 208
T LM + G+ +I + LL ADVN +S GNTAL G +DI+K+LL A +
Sbjct: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 320
Query: 209 EKDGY-GMTPLLSASVTGHTNIVDFLTHH 236
E G TPL+ A+ GH + L H
Sbjct: 321 EDHNENGHTPLMEAASAGHVEVARVLLDH 349
Score = 39.3 bits (90), Expect = 0.011
Identities = 19/56 (33%), Positives = 31/56 (55%)
Query: 503 CKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATN 558
C ++V +L++ GA VN+ SPL +AA H ++ LLI+ GA+ + N
Sbjct: 402 CMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVN 457
Score = 33.5 bits (75), Expect = 0.59
Identities = 20/61 (32%), Positives = 37/61 (60%), Gaps = 1/61 (1%)
Query: 508 LQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDA-TNLHKQTASD 566
+++ A+LIE GA++ + + +PL AA H +++ LL+ GA+ +A T ++TA
Sbjct: 440 VELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALT 499
Query: 567 L 567
L
Sbjct: 500 L 500
Score = 32.0 bits (71), Expect = 1.7
Identities = 14/48 (29%), Positives = 28/48 (58%)
Query: 508 LQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFD 555
L++ L+ GA+V+ + ++ L A N H D+ ++L+++GA D
Sbjct: 537 LELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 584
Score = 30.8 bits (68), Expect = 3.8
Identities = 19/56 (33%), Positives = 30/56 (53%), Gaps = 3/56 (5%)
Query: 509 QVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTA 564
+V LI+ GAD+ + S +PL A+ H +++ L+ SGA+ AT TA
Sbjct: 508 EVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTA 560
Score = 30.4 bits (67), Expect = 5.0
Identities = 15/50 (30%), Positives = 26/50 (52%)
Query: 503 CKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGA 552
C L + L+E GAD + + ++ L A ++ H ++ LL+ SGA
Sbjct: 369 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGA 418
Score = 30.0 bits (66), Expect = 6.6
Identities = 16/56 (28%), Positives = 28/56 (50%)
Query: 508 LQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQT 563
L + +L+ ADVN + + N+ L A DI+ +L+ GA+ + N + T
Sbjct: 274 LDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHT 329
>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 2 [Homo sapiens]
Length = 1390
Score = 99.4 bits (246), Expect = 9e-21
Identities = 73/229 (31%), Positives = 113/229 (49%), Gaps = 10/229 (4%)
Query: 3 LKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLE 62
L+ A+ AA G ++ LL + + EV ++ G T L AA G L++ E LL
Sbjct: 1033 LQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLG 1092
Query: 63 QCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRA 122
G +V+ G PPL+ A+ GH ++V+ LL G VN + TPL
Sbjct: 1093 H-------GAAVSRTNR--RGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMV 1143
Query: 123 ACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKG 182
A +GHL V++L+ A L ++ G + L +C KGH+ + QYL+E+GA +++ G
Sbjct: 1144 AACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNG 1203
Query: 183 NTALHDCAESGSLDIMKMLLMYCAKMEK-DGYGMTPLLSASVTGHTNIV 230
T L A G + + L+ A +E D GM PL A +T++V
Sbjct: 1204 RTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVV 1252
Score = 91.3 bits (225), Expect = 2e-18
Identities = 65/212 (30%), Positives = 101/212 (47%), Gaps = 14/212 (6%)
Query: 4 KTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQ 63
+TA+ AA GKL + LL + ++ G PL AAR GH +V LLE+
Sbjct: 1072 ETALTAAAGRGKLEVCELLLGHGA-----AVSRTNRRGVPPLFCAARQGHWQIVRLLLER 1126
Query: 64 CSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAA 123
G VN + +G PL A+ GHL V+ LL+ GA++++ + L A
Sbjct: 1127 -------GCDVNLSDK--QGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWA 1177
Query: 124 CFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGN 183
C GH +V+YLVE A ++ ++++G T L ++ + G E YL+EKGA + G
Sbjct: 1178 CLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGM 1237
Query: 184 TALHDCAESGSLDIMKMLLMYCAKMEKDGYGM 215
L + ++ LL AK+ + M
Sbjct: 1238 RPLDRAIGCRNTSVVVALLRKGAKLGNAAWAM 1269
Score = 71.2 bits (173), Expect = 3e-12
Identities = 72/235 (30%), Positives = 105/235 (44%), Gaps = 46/235 (19%)
Query: 5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLE-Q 63
TA+ AA G ++L+ L +K V L + G L+ +A GH D++++LL +
Sbjct: 962 TALCYAAAAGHMKLVC--LLTKKGVRVDHLDKK---GQCALVHSALRGHGDILQYLLTCE 1016
Query: 64 CSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLN----HGASVNNT-TLTNST 118
S G++ ++ A L AA++ GH VVQ LL H VN T TL T
Sbjct: 1017 WSPGPPQPGTLR-KSHALQQA--LTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGET 1073
Query: 119 PLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRK 178
L AA G LE+ + L+ H A + +NR G L + +GH +I + LLE+G DVN
Sbjct: 1074 ALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLS 1133
Query: 179 SVKGNTALHDCAESGSLDIMKMLLMYCAKMEKDGYGMTPLLSASVTGHTNIVDFL 233
D G TPL+ A+ GH + V+FL
Sbjct: 1134 --------------------------------DKQGRTPLMVAACEGHLSTVEFL 1156
Score = 65.1 bits (157), Expect = 2e-10
Identities = 57/192 (29%), Positives = 85/192 (44%), Gaps = 22/192 (11%)
Query: 71 GGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLE 130
G +VN+ E + AP L S GH +VV LL GA ++ T+ T L A GH++
Sbjct: 915 GANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMK 974
Query: 131 IVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLL-------EKGADVNRKSVKGN 183
+V L + ++ ++ G L+ S +GH +I QYLL RKS
Sbjct: 975 LVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQ 1034
Query: 184 TALHDCAESGSLDIMKMLLMYCAKMEKDG----------YGMTPLLSASVTGHTNIVDFL 233
AL A G +++ LL MEK+ +G T L +A+ G + + L
Sbjct: 1035 QALTAAASMGHSSVVQCLL----GMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELL 1090
Query: 234 T-HHAQTSKTER 244
H A S+T R
Sbjct: 1091 LGHGAAVSRTNR 1102
Score = 37.4 bits (85), Expect = 0.041
Identities = 16/44 (36%), Positives = 24/44 (54%)
Query: 509 QVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGA 552
Q+ +L+E G DVN+ D +PL +AA H + L+ GA
Sbjct: 1118 QIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGA 1161
>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 1 [Homo sapiens]
Length = 1861
Score = 99.4 bits (246), Expect = 9e-21
Identities = 73/229 (31%), Positives = 113/229 (49%), Gaps = 10/229 (4%)
Query: 3 LKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLE 62
L+ A+ AA G ++ LL + + EV ++ G T L AA G L++ E LL
Sbjct: 1041 LQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLG 1100
Query: 63 QCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRA 122
G +V+ G PPL+ A+ GH ++V+ LL G VN + TPL
Sbjct: 1101 H-------GAAVSRTNR--RGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMV 1151
Query: 123 ACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKG 182
A +GHL V++L+ A L ++ G + L +C KGH+ + QYL+E+GA +++ G
Sbjct: 1152 AACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNG 1211
Query: 183 NTALHDCAESGSLDIMKMLLMYCAKMEK-DGYGMTPLLSASVTGHTNIV 230
T L A G + + L+ A +E D GM PL A +T++V
Sbjct: 1212 RTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVV 1260
Score = 91.3 bits (225), Expect = 2e-18
Identities = 65/212 (30%), Positives = 101/212 (47%), Gaps = 14/212 (6%)
Query: 4 KTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQ 63
+TA+ AA GKL + LL + ++ G PL AAR GH +V LLE+
Sbjct: 1080 ETALTAAAGRGKLEVCELLLGHGA-----AVSRTNRRGVPPLFCAARQGHWQIVRLLLER 1134
Query: 64 CSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAA 123
G VN + +G PL A+ GHL V+ LL+ GA++++ + L A
Sbjct: 1135 -------GCDVNLSDK--QGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWA 1185
Query: 124 CFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGN 183
C GH +V+YLVE A ++ ++++G T L ++ + G E YL+EKGA + G
Sbjct: 1186 CLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGM 1245
Query: 184 TALHDCAESGSLDIMKMLLMYCAKMEKDGYGM 215
L + ++ LL AK+ + M
Sbjct: 1246 RPLDRAIGCRNTSVVVALLRKGAKLGNAAWAM 1277
Score = 71.2 bits (173), Expect = 3e-12
Identities = 72/235 (30%), Positives = 105/235 (44%), Gaps = 46/235 (19%)
Query: 5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLE-Q 63
TA+ AA G ++L+ L +K V L + G L+ +A GH D++++LL +
Sbjct: 970 TALCYAAAAGHMKLVC--LLTKKGVRVDHLDKK---GQCALVHSALRGHGDILQYLLTCE 1024
Query: 64 CSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLN----HGASVNNT-TLTNST 118
S G++ ++ A L AA++ GH VVQ LL H VN T TL T
Sbjct: 1025 WSPGPPQPGTLR-KSHALQQA--LTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGET 1081
Query: 119 PLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRK 178
L AA G LE+ + L+ H A + +NR G L + +GH +I + LLE+G DVN
Sbjct: 1082 ALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLS 1141
Query: 179 SVKGNTALHDCAESGSLDIMKMLLMYCAKMEKDGYGMTPLLSASVTGHTNIVDFL 233
D G TPL+ A+ GH + V+FL
Sbjct: 1142 --------------------------------DKQGRTPLMVAACEGHLSTVEFL 1164
Score = 65.1 bits (157), Expect = 2e-10
Identities = 57/192 (29%), Positives = 85/192 (44%), Gaps = 22/192 (11%)
Query: 71 GGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLE 130
G +VN+ E + AP L S GH +VV LL GA ++ T+ T L A GH++
Sbjct: 923 GANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMK 982
Query: 131 IVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLL-------EKGADVNRKSVKGN 183
+V L + ++ ++ G L+ S +GH +I QYLL RKS
Sbjct: 983 LVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQ 1042
Query: 184 TALHDCAESGSLDIMKMLLMYCAKMEKDG----------YGMTPLLSASVTGHTNIVDFL 233
AL A G +++ LL MEK+ +G T L +A+ G + + L
Sbjct: 1043 QALTAAASMGHSSVVQCLL----GMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELL 1098
Query: 234 T-HHAQTSKTER 244
H A S+T R
Sbjct: 1099 LGHGAAVSRTNR 1110
Score = 37.4 bits (85), Expect = 0.041
Identities = 16/44 (36%), Positives = 24/44 (54%)
Query: 509 QVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGA 552
Q+ +L+E G DVN+ D +PL +AA H + L+ GA
Sbjct: 1126 QIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGA 1169
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 99.4 bits (246), Expect = 9e-21
Identities = 158/629 (25%), Positives = 232/629 (36%), Gaps = 138/629 (21%)
Query: 4 KTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQ 63
K + AAR G KL+A + V+ S+ +TPL +AA Y + +V+ LL+
Sbjct: 336 KDELLEAARSGNEE---KLMALLTPLNVNCHASDGRK-STPLHLAAGYNRVRIVQLLLQH 391
Query: 64 CSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAA 123
G V+ + G PL A + GH +V + LL HGA VN L TPL A
Sbjct: 392 -------GADVHAKDKG--GLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEA 442
Query: 124 CFDGHLEIVKYLVEHKADLEVSNRH----------------------GHT---------- 151
+E+ L+ H AD + N H GH+
Sbjct: 443 ASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADL 502
Query: 152 -------------------------CLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTAL 186
C + S + K++ + LL KGA+VN K+ T L
Sbjct: 503 AKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPL 562
Query: 187 HDCAESGSLDIMKMLLMYCAKMEK-DGYGMTPLLSASVTGHTNIVDFLTHHAQTSKTERI 245
H AE D+M++L + AKM D G T L A++ GH L +
Sbjct: 563 HVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDP----- 617
Query: 246 NALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAKEVNSA 305
+ + L G T A + +A+ S+ T I + V L+ E + A
Sbjct: 618 SIISLQGFT----------AAQMGNEAVQQILSESTPIRTSDVDYRLL-------EASKA 660
Query: 306 EELEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINLWKYAL 365
+LE + + + R P H + Y R Y L +
Sbjct: 661 GDLETVKQLCSSQNVNCRDLEGRHSTPLH-FAAGYNRVSVVEY-----------LLHHGA 708
Query: 366 DMQQSNLDPLSPMTASSLLSFAELFSFMLQDRAKGLLGTTVTFDDLMGILCKSVLEIERA 425
D+ + L P+ + E+ +++ A + F L K EI +
Sbjct: 709 DVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKL 768
Query: 426 IKQTQCPADPLQLNKALSIILHLI--------CLLEKVPCTLEQDHFKKQTIYRFLKL-H 476
+ + ADP + N+ + L L+ LL L D KK + R KL
Sbjct: 769 L--LKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALL--DAAKKGCLARVQKLCT 824
Query: 477 PRGKN-------NFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDN 529
P N N +PLHLA N +L+V L+E GADVN +D
Sbjct: 825 PENINCRDTQGRNSTPLHLAAGYN-------------NLEVAEYLLEHGADVNAQDKGGL 871
Query: 530 SPLHIAALNNHPDIMNLLIKSGAHFDATN 558
PLH AA H DI LLIK +AT+
Sbjct: 872 IPLHNAASYGHVDIAALLIKYNTCVNATD 900
Score = 81.6 bits (200), Expect = 2e-15
Identities = 141/609 (23%), Positives = 220/609 (36%), Gaps = 113/609 (18%)
Query: 42 ATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQS 101
++PL AA +G D+VE LL+ N G PL A + GH +VV
Sbjct: 217 SSPLHFAAGFGRKDVVEHLLQM---------GANVHARDDGGLIPLHNACSFGHAEVVSL 267
Query: 102 LLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGH----------- 150
LL GA N N TPL A G +++ L++H AD + N G
Sbjct: 268 LLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAK 327
Query: 151 ----------------------------TCLMISCYK--GHKE-------------IAQY 167
T L ++C+ G K I Q
Sbjct: 328 AVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQL 387
Query: 168 LLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKMEK-DGYGMTPLLSASVTGH 226
LL+ GADV+ K G LH+ G ++ ++LL + A + D + TPL A+
Sbjct: 388 LLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNR 447
Query: 227 TNIVDFLTHHAQTSKTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISK 286
+ L H + + + R+ L Y K ++ + R ++K
Sbjct: 448 VEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRE---RLTYEFKGHSLLQAAREADLAK 504
Query: 287 PVPQTLIMAYDYAKEVNSAEE-LEGLIAD--PDEMRMQALLIRERILGPSHPDTSYYIRY 343
V +TL + K+ S E L +A P ++ LL+R+ G + + +
Sbjct: 505 -VKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRK---GANVNEKNKDFMT 560
Query: 344 RGAVYADSGNFKRCINLWKYALDMQQSNLDPLSPMT------ASSLLSFAELFSFMLQDR 397
V A+ + L K+ M LD L A L + L S+
Sbjct: 561 PLHVAAERAHNDVMEVLHKHGAKMNA--LDTLGQTALHRAALAGHLQTCRLLLSYGSDPS 618
Query: 398 AKGLLGTTVTFDDLMGILCKSVLEIERAIKQTQCPADPLQLNKALSI-ILHLICLLEKVP 456
L G T + + +L I+ + L+ +KA + + +C + V
Sbjct: 619 IISLQGFTAA--QMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVN 676
Query: 457 CT-LEQDH---------FKKQTIYRFL-----KLHPRGKNNFSPLHLAVDKNTTCVGRYP 501
C LE H + + ++ +L +H + K PLH A
Sbjct: 677 CRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNA------------ 724
Query: 502 VCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHK 561
C + +V +L+ GA VNV D +PLH AA +I LL+K GA N
Sbjct: 725 -CSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDG 783
Query: 562 QTASDLLDE 570
T DL+ E
Sbjct: 784 NTPLDLVKE 792
Score = 68.9 bits (167), Expect = 1e-11
Identities = 103/458 (22%), Positives = 183/458 (39%), Gaps = 62/458 (13%)
Query: 120 LRAACFDGHLEIVKYLVEHKADLEVSNRHGHTC--LMISCYKGHKEIAQYLLEKGADVNR 177
L AC +G + VK LV+ A++ + G L + G K++ ++LL+ GA+V+
Sbjct: 186 LLEACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHA 244
Query: 178 KSVKGNTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFLTHH 236
+ G LH+ G +++ +LL A +D + TPL A++ G ++ L H
Sbjct: 245 RDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQH 304
Query: 237 AQTSKTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAY 296
+ L K L G K + R + +++ P +
Sbjct: 305 GADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNC-- 362
Query: 297 DYAKEVNSAEELEGLIADPDEMRMQALLIRERI---------LGPSHPDTSYYIRYRGAV 347
+A + + L L A + +R+ LL++ L P H SY
Sbjct: 363 -HASDGRKSTPLH-LAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSY-------- 412
Query: 348 YADSGNFKRCINLWKYALDMQQSNLDPLSPMTASSLLSFAELFSFMLQDRAKGLLGTTVT 407
G+++ L K+ + +L +P+ ++ + E+ S +L A L
Sbjct: 413 ----GHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTL----- 463
Query: 408 FDDLMGILCKSVLEIERAIKQTQCPADPLQLNKALSIILHLICLLEKVPCTLEQDHFK-K 466
+ C ++ A P L+ H + + E D K K
Sbjct: 464 ------VNCHGKSAVDMA------PTPELRERLTYEFKGHSL-----LQAAREADLAKVK 506
Query: 467 QTIYRFLKLHPRGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDS 526
+T+ + + +++ + LH AV +P K QVT +L+ GA+VN ++
Sbjct: 507 KTLALEIINFKQPQSHETALHCAV------ASLHPKRK----QVTELLLRKGANVNEKNK 556
Query: 527 DDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTA 564
D +PLH+AA H D+M +L K GA +A + QTA
Sbjct: 557 DFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTA 594
Score = 63.2 bits (152), Expect = 7e-10
Identities = 56/189 (29%), Positives = 85/189 (44%), Gaps = 13/189 (6%)
Query: 43 TPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNF------DGET-----IEGAPPLWAAS 91
TPL AA G ++ + LL+ + + N +G+T + G L A+
Sbjct: 752 TPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAA 811
Query: 92 AAGHLKVVQSLLN-HGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGH 150
G L VQ L + +T NSTPL A +LE+ +YL+EH AD+ ++ G
Sbjct: 812 KKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGL 871
Query: 151 TCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCA-KME 209
L + GH +IA L++ VN T LH+ A+ G + +LL + A
Sbjct: 872 IPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTM 931
Query: 210 KDGYGMTPL 218
K+ G TPL
Sbjct: 932 KNQEGQTPL 940
Score = 58.9 bits (141), Expect = 1e-08
Identities = 59/214 (27%), Positives = 86/214 (40%), Gaps = 30/214 (14%)
Query: 45 LLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLN 104
LL A R G + V+ L++ +VN + PL A+ G VV+ LL
Sbjct: 186 LLEACRNGDVSRVKRLVD--------AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQ 237
Query: 105 HGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEI 164
GA+V+ PL AC GH E+V L+ AD + +T L + KG ++
Sbjct: 238 MGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDV 297
Query: 165 AQYLLEKGADVNRKSVKGNTALH--------------------DCAESGSLDIMKMLL-- 202
LL+ GAD N ++ G +AL + A SG+ + + LL
Sbjct: 298 CIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTP 357
Query: 203 MYCAKMEKDGYGMTPLLSASVTGHTNIVDFLTHH 236
+ DG TPL A+ IV L H
Sbjct: 358 LNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQH 391
Score = 58.9 bits (141), Expect = 1e-08
Identities = 44/152 (28%), Positives = 69/152 (45%), Gaps = 8/152 (5%)
Query: 35 ISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAG 94
I + G LL AA+ G L V+ L C+ ++N + PL A+
Sbjct: 797 IQDLLRGDAALLDAAKKGCLARVQKL---CTPE-----NINCRDTQGRNSTPLHLAAGYN 848
Query: 95 HLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLM 154
+L+V + LL HGA VN PL A GH++I L+++ + +++ T L
Sbjct: 849 NLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLH 908
Query: 155 ISCYKGHKEIAQYLLEKGADVNRKSVKGNTAL 186
+ KG ++ LL GAD K+ +G T L
Sbjct: 909 EAAQKGRTQLCALLLAHGADPTMKNQEGQTPL 940
Score = 51.2 bits (121), Expect = 3e-06
Identities = 34/114 (29%), Positives = 52/114 (45%), Gaps = 14/114 (12%)
Query: 475 LHPRGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHI 534
+H + K PLH A C + +VT +L++ GA VN D +PLH
Sbjct: 395 VHAKDKGGLVPLHNA-------------CSYGHYEVTELLLKHGACVNAMDLWQFTPLHE 441
Query: 535 AALNNHPDIMNLLIKSGAHFDATNLHKQTASDLLDEKEIAKNLIQPI-NHTTLQ 587
AA N ++ +LL+ GA N H ++A D+ E+ + L H+ LQ
Sbjct: 442 AASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQ 495
Score = 32.7 bits (73), Expect = 1.0
Identities = 28/98 (28%), Positives = 39/98 (39%), Gaps = 9/98 (9%)
Query: 29 EEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLW 88
E + + ++ G PL AA YGH+D+ L I+ VN + PL
Sbjct: 858 EHGADVNAQDKGGLIPLHNAASYGHVDIAALL-------IKYNTCVNATDKW--AFTPLH 908
Query: 89 AASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFD 126
A+ G ++ LL HGA TPL A D
Sbjct: 909 EAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATAD 946
Score = 30.0 bits (66), Expect = 6.6
Identities = 21/66 (31%), Positives = 32/66 (48%), Gaps = 16/66 (24%)
Query: 483 FSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPD 542
F+PLH A K T Q+ A+L+ GAD +++ + +PL +A + D
Sbjct: 904 FTPLHEAAQKGRT-------------QLCALLLAHGADPTMKNQEGQTPLDLATAD---D 947
Query: 543 IMNLLI 548
I LLI
Sbjct: 948 IRALLI 953
>gi|155969701 espin-like [Homo sapiens]
Length = 1005
Score = 98.6 bits (244), Expect = 2e-20
Identities = 77/240 (32%), Positives = 119/240 (49%), Gaps = 17/240 (7%)
Query: 5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQC 64
T +AA G L L L+ +E L + +G +PL +AAR+GH +VE+LL +
Sbjct: 72 TPAHDAAATGSLAELCWLV----REGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHE- 126
Query: 65 SASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLN-HGASVNNTTLTNSTPLRAA 123
G S ET EGA PL A+ +G L ++ L HG+SVN T + ++PL A
Sbjct: 127 ------GHSATL--ETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLA 178
Query: 124 CFDGHLEIVKYLVEH-KADLEVSNRHGHTCLMISCYKGHKEIAQYLLE-KGADVNRKSVK 181
C +GHL + ++LV+ AD+ + G + L + +GH + +L+ + + +
Sbjct: 179 CQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNE 238
Query: 182 GNTALHDCAESGSLDIMKMLLMYCAKMEKDGYGMTPLLSASVTGHTNIVDFL-THHAQTS 240
G TALH A G I+ LL+ + +D +G TPL A+ G L +HH S
Sbjct: 239 GATALHFAARGGHTPILDRLLLMGTPILRDSWGGTPLHDAAENGQMECCQTLVSHHVDPS 298
Score = 81.6 bits (200), Expect = 2e-15
Identities = 73/256 (28%), Positives = 113/256 (44%), Gaps = 38/256 (14%)
Query: 10 AARDGKLRLLTKLLASKSKEEVSSLISEKTN--GATPLLMAARYGHLDMVEFLLEQCSAS 67
AA+DG + L +LL E +L T+ GA + A R GHLD V+FL+++
Sbjct: 9 AAKDGDVATLERLL------EAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLP 62
Query: 68 --------------------------IEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQS 101
+ G + G PL A+ GH +V+
Sbjct: 63 GNQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEW 122
Query: 102 LLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYL-VEHKADLEVSNRHGHTCLMISCYKG 160
LL+ G S T + PL A G L +K L H + + R G + L ++C +G
Sbjct: 123 LLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEG 182
Query: 161 HKEIAQYLLEK-GADVNRKSVKGNTALHDCAESGSLDIMKMLLMY--CAKMEKDGYGMTP 217
H +AQ+L++ GADV+ +++ G +ALH A G ++ L+ + +D G T
Sbjct: 183 HLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATA 242
Query: 218 LLSASVTGHTNIVDFL 233
L A+ GHT I+D L
Sbjct: 243 LHFAARGGHTPILDRL 258
Score = 69.7 bits (169), Expect = 7e-12
Identities = 51/188 (27%), Positives = 80/188 (42%), Gaps = 31/188 (16%)
Query: 9 NAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASI 68
+AA G L L L A+ SS+ +GA+PL +A + GHL + +FL++ C A +
Sbjct: 143 HAAVSGDLTCLKLLTAAHG----SSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGADV 198
Query: 69 EVGG--------------------------SVNFDGETIEGAPPLWAASAAGHLKVVQSL 102
+ + EGA L A+ GH ++ L
Sbjct: 199 HLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRL 258
Query: 103 LNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHK 162
L G + + TPL A +G +E + LV H D + + G+T ++ Y GH+
Sbjct: 259 LLMGTPILRDSW-GGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHR 317
Query: 163 EIAQYLLE 170
+ AQYL E
Sbjct: 318 DCAQYLRE 325
Score = 43.1 bits (100), Expect = 7e-04
Identities = 25/87 (28%), Positives = 47/87 (54%), Gaps = 3/87 (3%)
Query: 160 GHKEIAQYLLEKGA-DVNRKSVKGNTALHDCAESGSLDIMKMLLMY--CAKMEKDGYGMT 216
GH + ++L+++ N+++ G T HD A +GSL + L+ C ++D G++
Sbjct: 47 GHLDCVKFLVQRAQLPGNQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVS 106
Query: 217 PLLSASVTGHTNIVDFLTHHAQTSKTE 243
PL A+ GH +V++L H ++ E
Sbjct: 107 PLHLAARFGHPVLVEWLLHEGHSATLE 133
Score = 33.9 bits (76), Expect = 0.45
Identities = 23/72 (31%), Positives = 35/72 (48%), Gaps = 14/72 (19%)
Query: 478 RGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILI-ECGADVNVRDSDDNSPLHIAA 536
R ++ SPL+LA C+ L + L+ +CGADV++R D S LH AA
Sbjct: 167 RTRSGASPLYLA-------------CQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAA 213
Query: 537 LNNHPDIMNLLI 548
H ++ L+
Sbjct: 214 ARGHYSLVVWLV 225
>gi|70995267 ankyrin repeat domain 29 [Homo sapiens]
Length = 301
Score = 95.5 bits (236), Expect = 1e-19
Identities = 76/257 (29%), Positives = 122/257 (47%), Gaps = 32/257 (12%)
Query: 3 LKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMV-EFLL 61
L A F AAR G L LL KLL + + +V ++G T L++AA GH+D V E +L
Sbjct: 12 LANAAFWAARRGNLALL-KLLLNSGRVDVDC---RDSHGTTLLMVAAYAGHIDCVRELVL 67
Query: 62 EQCSASIE-------------------------VGGSVNFDGETIEGAPPLWAASAAGHL 96
+ +++ G S F T +G L AAS GH+
Sbjct: 68 QGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEF--RTKDGGTALLAASQYGHM 125
Query: 97 KVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMIS 156
+VV++LL HGA++++ +T L A G+L++++ L+ A + + G L I+
Sbjct: 126 QVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIA 185
Query: 157 CYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKMEKDGYGMT 216
GH E+ + +L +GAD + G TAL A G D++K LL + + G +
Sbjct: 186 SQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGILKNGTS 245
Query: 217 PLLSASVTGHTNIVDFL 233
L +A ++G+ V L
Sbjct: 246 ALHAAVLSGNIKTVALL 262
Score = 92.0 bits (227), Expect = 1e-18
Identities = 61/195 (31%), Positives = 99/195 (50%), Gaps = 9/195 (4%)
Query: 37 EKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHL 96
++T A AAR G+L +++ LL G V+ D G L A+ AGH+
Sbjct: 8 KETPLANAAFWAARRGNLALLKLLLNS--------GRVDVDCRDSHGTTLLMVAAYAGHI 59
Query: 97 KVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMIS 156
V+ L+ GA +N + +T L A GH ++V++L A E + G T L+ +
Sbjct: 60 DCVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAA 119
Query: 157 CYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKMEKDGY-GM 215
GH ++ + LL+ GA+++ + G TAL A+ G LD++++LL AK+ + G
Sbjct: 120 SQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGT 179
Query: 216 TPLLSASVTGHTNIV 230
PL AS GH+ +V
Sbjct: 180 APLWIASQMGHSEVV 194
Score = 47.8 bits (112), Expect = 3e-05
Identities = 42/147 (28%), Positives = 71/147 (48%), Gaps = 17/147 (11%)
Query: 2 DLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLL 61
D TA+F AA+ G L ++ LLAS +K + + +G PL +A++ GH ++V +L
Sbjct: 144 DGATALFLAAQGGYLDVIRLLLASGAK-----VNQPRQDGTAPLWIASQMGHSEVVRVML 198
Query: 62 EQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNST-PL 120
+ + D +G L A+ G+ V++ LL ++ L N T L
Sbjct: 199 LR---------GADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLG--ILKNGTSAL 247
Query: 121 RAACFDGHLEIVKYLVEHKADLEVSNR 147
AA G+++ V L+E AD + N+
Sbjct: 248 HAAVLSGNIKTVALLLEAGADPSLRNK 274
Score = 30.4 bits (67), Expect = 5.0
Identities = 15/49 (30%), Positives = 30/49 (61%)
Query: 504 KFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGA 552
++ +QV L++ GA+++ + D + L +AA + D++ LL+ SGA
Sbjct: 121 QYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGA 169
>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 2 [Homo sapiens]
Length = 1990
Score = 95.1 bits (235), Expect = 2e-19
Identities = 72/234 (30%), Positives = 111/234 (47%), Gaps = 15/234 (6%)
Query: 3 LKTAVFNAARDGKLRLLTKLL--ASKSKEEVSSLISEKTN---GATPLLMAARYGHLDMV 57
++ A+ AA G +++ LL K +EEV + G T L AA G L++
Sbjct: 991 IQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVC 1050
Query: 58 EFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNS 117
LLEQ +A + GA PL++ GH ++V LL HGA VN
Sbjct: 1051 RLLLEQGAAVAQPNR---------RGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGR 1101
Query: 118 TPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNR 177
TPL A +GHL V +L+ A + + ++ G T L +C KGH + + L++ GA +
Sbjct: 1102 TPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDH 1161
Query: 178 KSVKGNTALHDCAESGSLDIMKMLLMYCAKMEKDGY-GMTPLLSASVTGHTNIV 230
G T L A G ++++ L+ + A +E Y GM PL A +T++V
Sbjct: 1162 ADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVV 1215
Score = 86.7 bits (213), Expect = 6e-17
Identities = 62/205 (30%), Positives = 97/205 (47%), Gaps = 14/205 (6%)
Query: 4 KTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQ 63
+TA+ AA GKL + LL E+ +++ GA PL R GH +V+ LL
Sbjct: 1035 ETALTAAAGRGKLEVCRLLL-----EQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTH 1089
Query: 64 CSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAA 123
G VN + +G PL A++ GHL V LL GAS+ T L A
Sbjct: 1090 -------GADVNMADK--QGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWA 1140
Query: 124 CFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGN 183
C GHL +V+ LV++ A + ++++G T L ++ + G E+ Q+L++ GA + G
Sbjct: 1141 CLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGM 1200
Query: 184 TALHDCAESGSLDIMKMLLMYCAKM 208
L + ++ LL AK+
Sbjct: 1201 RPLDRAVGCRNTSVVVTLLKKGAKI 1225
Score = 75.1 bits (183), Expect = 2e-13
Identities = 68/237 (28%), Positives = 104/237 (43%), Gaps = 28/237 (11%)
Query: 36 SEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGH 95
+E N A L + + G+ +MV LLE N D + G PL A+AAG+
Sbjct: 880 TEVLNNAPILCVQSHLGYTEMVALLLEF---------GANVDASSESGLTPLGYAAAAGY 930
Query: 96 LKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVE-------HKADLEVSNRH 148
L +V L A V++ L A GHLE+VK+L++ + + +
Sbjct: 931 LSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHA 990
Query: 149 GHTCLMISCYKGHKEIAQYLLE---------KGADVNR-KSVKGNTALHDCAESGSLDIM 198
L+ + G+ EI YLL+ + A +N S+ G TAL A G L++
Sbjct: 991 IQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVC 1050
Query: 199 KMLLMYCAKM-EKDGYGMTPLLSASVTGHTNIVD-FLTHHAQTSKTERINALELLGA 253
++LL A + + + G PL S GH IVD LTH A + ++ L+ A
Sbjct: 1051 RLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMA 1107
Score = 34.7 bits (78), Expect = 0.27
Identities = 16/44 (36%), Positives = 25/44 (56%)
Query: 509 QVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGA 552
Q+ +L+ GADVN+ D +PL +AA H ++ L+ GA
Sbjct: 1081 QIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGA 1124
Score = 32.3 bits (72), Expect = 1.3
Identities = 24/74 (32%), Positives = 37/74 (50%), Gaps = 3/74 (4%)
Query: 509 QVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTA---S 565
++ A+L+E GA+V+ +PL AA + I+ LL K A D + + Q A +
Sbjct: 899 EMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHA 958
Query: 566 DLLDEKEIAKNLIQ 579
L E+ K LIQ
Sbjct: 959 ALRGHLEVVKFLIQ 972
>gi|34304381 inversin isoform a [Homo sapiens]
Length = 1065
Score = 95.1 bits (235), Expect = 2e-19
Identities = 90/325 (27%), Positives = 145/325 (44%), Gaps = 29/325 (8%)
Query: 4 KTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQ 63
+T+ AA G +L +L+ KS +++ +++K G T L AA GH+ V+ LLE
Sbjct: 323 RTSFMWAAGKGSDDVLRTMLSLKSDIDIN--MADKYGG-TALHAAALSGHVSTVKLLLEN 379
Query: 64 CSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAA 123
+ D + PL+ A GH V+Q+L+ GA V+ + L A
Sbjct: 380 ---------NAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWA 430
Query: 124 CFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGN 183
G+ ++ + L+E+K + V + G T L + Y G+ L+E AD N + +G
Sbjct: 431 ALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGR 490
Query: 184 TALHDCAESGSLDIMKMLLMYCA---KMEKDGYGMTPLLSASVTGHTNIVDFLTHHAQTS 240
TALH +G LD +K+LL + A +ME + TPL A + ++ F+ H S
Sbjct: 491 TALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGALS 550
Query: 241 KTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAK 300
I A++ + A + K +K + + DR N++ K A +
Sbjct: 551 ----IAAIQDIAAFKIQ------AVYKGYK--VRKAFRDRKNLLMKHEQLRKDAAAKKRE 598
Query: 301 EVNSAEELEGLIA--DPDEMRMQAL 323
E N +E E PD R QAL
Sbjct: 599 EENKRKEAEQQKGRRSPDSCRPQAL 623
Score = 67.0 bits (162), Expect = 5e-11
Identities = 58/197 (29%), Positives = 91/197 (46%), Gaps = 12/197 (6%)
Query: 41 GATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQ 100
G TPL A G++ +V+ L S +I ++D + P WAA GH ++V
Sbjct: 221 GRTPLHFAVADGNVTVVDVLTSYESCNI-----TSYDN--LFRTPLHWAA-LLGHAQIVH 272
Query: 101 SLLNHGASVN-NTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYK 159
LL S + +TPL A E VK ++H + + S+ G T M + K
Sbjct: 273 LLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGK 332
Query: 160 GHKEIAQYL--LEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMT 216
G ++ + + L+ D+N G TALH A SG + +K+LL A+++ D T
Sbjct: 333 GSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHT 392
Query: 217 PLLSASVTGHTNIVDFL 233
PL A GH +++ L
Sbjct: 393 PLFRACEMGHKDVIQTL 409
Score = 47.4 bits (111), Expect = 4e-05
Identities = 32/87 (36%), Positives = 45/87 (51%), Gaps = 1/87 (1%)
Query: 133 KYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAES 192
+ +V + A + ++ G T LM + A LL+ GADVN+ TALH A+
Sbjct: 32 RLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQK 91
Query: 193 GSLDIMKMLLMYCAK-MEKDGYGMTPL 218
G+ MK+LL A M+KD MTPL
Sbjct: 92 GNYRFMKLLLTRRANWMQKDLEEMTPL 118
Score = 45.1 bits (105), Expect = 2e-04
Identities = 53/219 (24%), Positives = 79/219 (36%), Gaps = 42/219 (19%)
Query: 70 VGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHL 129
VG S D E G PL A L +LL GA VN T + T L A G+
Sbjct: 35 VGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNY 94
Query: 130 EIVKYLVEHKAD-----------LEVSNRHG------------------------HTCLM 154
+K L+ +A+ L ++ RH T L
Sbjct: 95 RFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALH 154
Query: 155 ISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKML--LMYCAKME--- 209
S Y + E + L++ +++ V+G LH A + + ++ A E
Sbjct: 155 WSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLL 214
Query: 210 --KDGYGMTPLLSASVTGHTNIVDFLTHHAQTSKTERIN 246
+D G TPL A G+ +VD LT + + T N
Sbjct: 215 NWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDN 253
Score = 39.7 bits (91), Expect = 0.008
Identities = 18/53 (33%), Positives = 31/53 (58%)
Query: 511 TAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQT 563
T + ++ D+N+ D + LH AAL+ H + LL+++ A DAT++ K T
Sbjct: 340 TMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHT 392
Score = 35.8 bits (81), Expect = 0.12
Identities = 31/129 (24%), Positives = 55/129 (42%), Gaps = 1/129 (0%)
Query: 84 APPLWAASAAGHLKVVQSLL-NHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADL 142
A + AA+ G +Q L+ + A + TPL L+ L++ AD+
Sbjct: 15 ASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADV 74
Query: 143 EVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLL 202
++ T L ++ KG+ + LL + A+ +K ++ T LH S + +LL
Sbjct: 75 NKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLL 134
Query: 203 MYCAKMEKD 211
+ A E D
Sbjct: 135 KFMAPGEVD 143
Score = 35.8 bits (81), Expect = 0.12
Identities = 28/96 (29%), Positives = 40/96 (41%), Gaps = 12/96 (12%)
Query: 513 ILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATN------LH------ 560
+L+E A V+ D ++PL A H D++ LIK GA D + LH
Sbjct: 375 LLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGG 434
Query: 561 KQTASDLLDEKEIAKNLIQPINHTTLQCLAARVIVN 596
+L E +I N+ T LQC A +N
Sbjct: 435 NADVCQILIENKINPNVQDYAGRTPLQCAAYGGYIN 470
Score = 34.7 bits (78), Expect = 0.27
Identities = 18/51 (35%), Positives = 29/51 (56%)
Query: 500 YPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKS 550
+ C+ V LI+ GA V++ D D +S LH AAL + D+ +LI++
Sbjct: 395 FRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIEN 445
Score = 33.1 bits (74), Expect = 0.78
Identities = 17/50 (34%), Positives = 27/50 (54%)
Query: 514 LIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQT 563
L++ GADVN D + LH+AA + M LL+ A++ +L + T
Sbjct: 67 LLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMT 116
Score = 31.6 bits (70), Expect = 2.3
Identities = 29/100 (29%), Positives = 50/100 (50%), Gaps = 10/100 (10%)
Query: 512 AILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFD--ATNLHKQTASD--L 567
A+L+E AD N++D + + LH + N + D + LL+ A + N + T D L
Sbjct: 473 AVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYAL 532
Query: 568 LDEK-EIAKNLIQPINHTTLQCLAARVIVNHRI--YYKGH 604
L E+ E+ + +++ H L A + I +I YKG+
Sbjct: 533 LGERHEVIQFMLE---HGALSIAAIQDIAAFKIQAVYKGY 569
Score = 30.4 bits (67), Expect = 5.0
Identities = 27/88 (30%), Positives = 41/88 (46%), Gaps = 19/88 (21%)
Query: 470 YRFLKLHPRGKNNF--------SPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADV 521
YRF+KL + N+ +PLHL T R P C L+ A +V
Sbjct: 94 YRFMKLLLTRRANWMQKDLEEMTPLHL------TTRHRSPKCLALLLKFMA-----PGEV 142
Query: 522 NVRDSDDNSPLHIAALNNHPDIMNLLIK 549
+ +D + + LH +A N+P+ + LLIK
Sbjct: 143 DTQDKNKQTALHWSAYYNNPEHVKLLIK 170
>gi|34304379 inversin isoform b [Homo sapiens]
Length = 895
Score = 95.1 bits (235), Expect = 2e-19
Identities = 90/325 (27%), Positives = 145/325 (44%), Gaps = 29/325 (8%)
Query: 4 KTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQ 63
+T+ AA G +L +L+ KS +++ +++K G T L AA GH+ V+ LLE
Sbjct: 323 RTSFMWAAGKGSDDVLRTMLSLKSDIDIN--MADKYGG-TALHAAALSGHVSTVKLLLEN 379
Query: 64 CSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAA 123
+ D + PL+ A GH V+Q+L+ GA V+ + L A
Sbjct: 380 ---------NAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWA 430
Query: 124 CFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGN 183
G+ ++ + L+E+K + V + G T L + Y G+ L+E AD N + +G
Sbjct: 431 ALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGR 490
Query: 184 TALHDCAESGSLDIMKMLLMYCA---KMEKDGYGMTPLLSASVTGHTNIVDFLTHHAQTS 240
TALH +G LD +K+LL + A +ME + TPL A + ++ F+ H S
Sbjct: 491 TALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGALS 550
Query: 241 KTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAK 300
I A++ + A + K +K + + DR N++ K A +
Sbjct: 551 ----IAAIQDIAAFKIQ------AVYKGYK--VRKAFRDRKNLLMKHEQLRKDAAAKKRE 598
Query: 301 EVNSAEELEGLIA--DPDEMRMQAL 323
E N +E E PD R QAL
Sbjct: 599 EENKRKEAEQQKGRRSPDSCRPQAL 623
Score = 67.0 bits (162), Expect = 5e-11
Identities = 58/197 (29%), Positives = 91/197 (46%), Gaps = 12/197 (6%)
Query: 41 GATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQ 100
G TPL A G++ +V+ L S +I ++D + P WAA GH ++V
Sbjct: 221 GRTPLHFAVADGNVTVVDVLTSYESCNI-----TSYDN--LFRTPLHWAA-LLGHAQIVH 272
Query: 101 SLLNHGASVN-NTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYK 159
LL S + +TPL A E VK ++H + + S+ G T M + K
Sbjct: 273 LLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGK 332
Query: 160 GHKEIAQYL--LEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMT 216
G ++ + + L+ D+N G TALH A SG + +K+LL A+++ D T
Sbjct: 333 GSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHT 392
Query: 217 PLLSASVTGHTNIVDFL 233
PL A GH +++ L
Sbjct: 393 PLFRACEMGHKDVIQTL 409
Score = 47.4 bits (111), Expect = 4e-05
Identities = 32/87 (36%), Positives = 45/87 (51%), Gaps = 1/87 (1%)
Query: 133 KYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAES 192
+ +V + A + ++ G T LM + A LL+ GADVN+ TALH A+
Sbjct: 32 RLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQK 91
Query: 193 GSLDIMKMLLMYCAK-MEKDGYGMTPL 218
G+ MK+LL A M+KD MTPL
Sbjct: 92 GNYRFMKLLLTRRANWMQKDLEEMTPL 118
Score = 45.1 bits (105), Expect = 2e-04
Identities = 53/219 (24%), Positives = 79/219 (36%), Gaps = 42/219 (19%)
Query: 70 VGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHL 129
VG S D E G PL A L +LL GA VN T + T L A G+
Sbjct: 35 VGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNY 94
Query: 130 EIVKYLVEHKAD-----------LEVSNRHG------------------------HTCLM 154
+K L+ +A+ L ++ RH T L
Sbjct: 95 RFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALH 154
Query: 155 ISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKML--LMYCAKME--- 209
S Y + E + L++ +++ V+G LH A + + ++ A E
Sbjct: 155 WSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLL 214
Query: 210 --KDGYGMTPLLSASVTGHTNIVDFLTHHAQTSKTERIN 246
+D G TPL A G+ +VD LT + + T N
Sbjct: 215 NWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDN 253
Score = 39.7 bits (91), Expect = 0.008
Identities = 18/53 (33%), Positives = 31/53 (58%)
Query: 511 TAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQT 563
T + ++ D+N+ D + LH AAL+ H + LL+++ A DAT++ K T
Sbjct: 340 TMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHT 392
Score = 35.8 bits (81), Expect = 0.12
Identities = 31/129 (24%), Positives = 55/129 (42%), Gaps = 1/129 (0%)
Query: 84 APPLWAASAAGHLKVVQSLL-NHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADL 142
A + AA+ G +Q L+ + A + TPL L+ L++ AD+
Sbjct: 15 ASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADV 74
Query: 143 EVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLL 202
++ T L ++ KG+ + LL + A+ +K ++ T LH S + +LL
Sbjct: 75 NKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLL 134
Query: 203 MYCAKMEKD 211
+ A E D
Sbjct: 135 KFMAPGEVD 143
Score = 35.8 bits (81), Expect = 0.12
Identities = 28/96 (29%), Positives = 40/96 (41%), Gaps = 12/96 (12%)
Query: 513 ILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATN------LH------ 560
+L+E A V+ D ++PL A H D++ LIK GA D + LH
Sbjct: 375 LLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGG 434
Query: 561 KQTASDLLDEKEIAKNLIQPINHTTLQCLAARVIVN 596
+L E +I N+ T LQC A +N
Sbjct: 435 NADVCQILIENKINPNVQDYAGRTPLQCAAYGGYIN 470
Score = 34.7 bits (78), Expect = 0.27
Identities = 18/51 (35%), Positives = 29/51 (56%)
Query: 500 YPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKS 550
+ C+ V LI+ GA V++ D D +S LH AAL + D+ +LI++
Sbjct: 395 FRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIEN 445
Score = 33.1 bits (74), Expect = 0.78
Identities = 17/50 (34%), Positives = 27/50 (54%)
Query: 514 LIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQT 563
L++ GADVN D + LH+AA + M LL+ A++ +L + T
Sbjct: 67 LLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMT 116
Score = 31.6 bits (70), Expect = 2.3
Identities = 29/100 (29%), Positives = 50/100 (50%), Gaps = 10/100 (10%)
Query: 512 AILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFD--ATNLHKQTASD--L 567
A+L+E AD N++D + + LH + N + D + LL+ A + N + T D L
Sbjct: 473 AVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYAL 532
Query: 568 LDEK-EIAKNLIQPINHTTLQCLAARVIVNHRI--YYKGH 604
L E+ E+ + +++ H L A + I +I YKG+
Sbjct: 533 LGERHEVIQFMLE---HGALSIAAIQDIAAFKIQAVYKGY 569
Score = 30.4 bits (67), Expect = 5.0
Identities = 27/88 (30%), Positives = 41/88 (46%), Gaps = 19/88 (21%)
Query: 470 YRFLKLHPRGKNNF--------SPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADV 521
YRF+KL + N+ +PLHL T R P C L+ A +V
Sbjct: 94 YRFMKLLLTRRANWMQKDLEEMTPLHL------TTRHRSPKCLALLLKFMA-----PGEV 142
Query: 522 NVRDSDDNSPLHIAALNNHPDIMNLLIK 549
+ +D + + LH +A N+P+ + LLIK
Sbjct: 143 DTQDKNKQTALHWSAYYNNPEHVKLLIK 170
>gi|116875852 HECT domain and ankyrin repeat containing, E3
ubiquitin protein ligase 1 [Homo sapiens]
Length = 909
Score = 94.0 bits (232), Expect = 4e-19
Identities = 58/174 (33%), Positives = 89/174 (51%), Gaps = 9/174 (5%)
Query: 45 LLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLN 104
L +AA G ++ + LL++ G + N+ + I G PL A+ G K + LL
Sbjct: 69 LHIAANCGSVECLVLLLKK-------GANPNY--QDISGCTPLHLAARNGQKKCMSKLLE 119
Query: 105 HGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEI 164
+ A VN T + +G E++ LV+H +D++V + G T L ++C GHK
Sbjct: 120 YSADVNICNNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALHVACQNGHKTT 179
Query: 165 AQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKMEKDGYGMTPL 218
Q LL+ GAD+NR +V G T L+ G D ++LL+ AK D G+TPL
Sbjct: 180 VQCLLDSGADINRPNVSGATPLYFACSHGQRDTAQILLLRGAKYLPDKNGVTPL 233
Score = 65.5 bits (158), Expect = 1e-10
Identities = 54/195 (27%), Positives = 85/195 (43%), Gaps = 15/195 (7%)
Query: 10 AARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIE 69
AA G + L LL + + +G TPL +AAR G + LLE SA +
Sbjct: 72 AANCGSVECLVLLLKKGANPNYQDI-----SGCTPLHLAARNGQKKCMSKLLEY-SADVN 125
Query: 70 VGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHL 129
+ + EG + + G +++ L+ H + V+ T L AC +GH
Sbjct: 126 ICNN--------EGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALHVACQNGHK 177
Query: 130 EIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDC 189
V+ L++ AD+ N G T L +C G ++ AQ LL +GA G T L C
Sbjct: 178 TTVQCLLDSGADINRPNVSGATPLYFACSHGQRDTAQILLLRGAKY-LPDKNGVTPLDLC 236
Query: 190 AESGSLDIMKMLLMY 204
+ G + ++L+ Y
Sbjct: 237 VQGGYGETCEVLIQY 251
Score = 35.0 bits (79), Expect = 0.20
Identities = 22/84 (26%), Positives = 42/84 (50%), Gaps = 3/84 (3%)
Query: 507 SLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTASD 566
S++ +L++ GA+ N +D +PLH+AA N M+ L++ A + N TA
Sbjct: 77 SVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNICNNEGLTAIH 136
Query: 567 LL---DEKEIAKNLIQPINHTTLQ 587
L E+ +L+Q ++ ++
Sbjct: 137 WLAVNGRTELLHDLVQHVSDVDVE 160
Score = 33.5 bits (75), Expect = 0.59
Identities = 16/50 (32%), Positives = 27/50 (54%)
Query: 514 LIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQT 563
L++ +DV+V D+ + LH+A N H + L+ SGA + N+ T
Sbjct: 150 LVQHVSDVDVEDAMGQTALHVACQNGHKTTVQCLLDSGADINRPNVSGAT 199
Score = 31.6 bits (70), Expect = 2.3
Identities = 20/76 (26%), Positives = 39/76 (51%), Gaps = 9/76 (11%)
Query: 514 LIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTASDLLDEKEI 573
L+E ADVN+ +++ + +H A+N ++++ L++ + D + QTA +
Sbjct: 117 LLEYSADVNICNNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALHV------ 170
Query: 574 AKNLIQPINHTTLQCL 589
Q + TT+QCL
Sbjct: 171 ---ACQNGHKTTVQCL 183
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 93.6 bits (231), Expect = 5e-19
Identities = 72/229 (31%), Positives = 111/229 (48%), Gaps = 15/229 (6%)
Query: 6 AVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCS 65
AV+ AAR G + L L +K +V +G L +AARYGH D+ + L CS
Sbjct: 415 AVYWAARHGHVDTLKFLSENKCPLDVKD-----KSGEMALHVAARYGHADVAQLL---CS 466
Query: 66 ASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACF 125
G + N + E PL A+ G+ V ++L G +VN TPL A
Sbjct: 467 ----FGSNPNIQDK--EEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASA 520
Query: 126 DGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTA 185
G+ +IV+ L EH ADL ++ GH L ++ + E+ + LL +G V+ + GNT
Sbjct: 521 RGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTP 580
Query: 186 LHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFL 233
LH + G++ I+ L ++ + YG TPL A+ G ++V +L
Sbjct: 581 LHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYL 629
Score = 93.2 bits (230), Expect = 6e-19
Identities = 66/222 (29%), Positives = 105/222 (47%), Gaps = 15/222 (6%)
Query: 10 AARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIE 69
AA G +++L L+ S+ +V + G+ + AAR+GH+D ++FL E
Sbjct: 386 AAGCGNIQILQLLIKRGSRIDV-----QDKGGSNAVYWAARHGHVDTLKFLSEN------ 434
Query: 70 VGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHL 129
D + G L A+ GH V Q L + G++ N TPL A + G+
Sbjct: 435 ---KCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYY 491
Query: 130 EIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDC 189
+ K L E ++ + NR G T L+ + +G+ +I + L E GAD+N G+ ALH
Sbjct: 492 SVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLA 551
Query: 190 AESGSLDIMKMLLMY-CAKMEKDGYGMTPLLSASVTGHTNIV 230
++++K LL C +D +G TPL A G+ IV
Sbjct: 552 VRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIV 593
Score = 84.7 bits (208), Expect = 2e-16
Identities = 49/155 (31%), Positives = 82/155 (52%), Gaps = 1/155 (0%)
Query: 83 GAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADL 142
G PPL A+ G+++++Q L+ G+ ++ S + A GH++ +K+L E+K L
Sbjct: 379 GTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPL 438
Query: 143 EVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLL 202
+V ++ G L ++ GH ++AQ L G++ N + + T LH A G + K L
Sbjct: 439 DVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALC 498
Query: 203 -MYCAKMEKDGYGMTPLLSASVTGHTNIVDFLTHH 236
C K+ G TPLL+AS G+ +IV+ L H
Sbjct: 499 EAGCNVNIKNREGETPLLTASARGYHDIVECLAEH 533
Score = 43.9 bits (102), Expect = 4e-04
Identities = 40/161 (24%), Positives = 68/161 (42%), Gaps = 24/161 (14%)
Query: 41 GATPLLMAARYGHLDMVEFLLEQCS-------------------ASIEVGGSVNFDGETI 81
G TPLL A+ G+ D+VE L E + +EV ++ G +
Sbjct: 511 GETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFV 570
Query: 82 E-----GAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLV 136
+ G PL A G++ +V +L +++ + TPL A +G L++V+YL
Sbjct: 571 DYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLC 630
Query: 137 EHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNR 177
A +E G T ++ + H+ +A L D +R
Sbjct: 631 LMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLRKDTHR 671
Score = 40.4 bits (93), Expect = 0.005
Identities = 35/138 (25%), Positives = 58/138 (42%), Gaps = 26/138 (18%)
Query: 433 ADPLQLNKALSIILHLI---CLLEKVPCTLEQDHFKKQTIYRFLKLHPRGKNNFSPLHLA 489
AD +K I LHL C +E + L Q F + + ++ +PLH+A
Sbjct: 535 ADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCF----------VDYQDRHGNTPLHVA 584
Query: 490 VDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIK 549
CK ++ + L E ++++ + +PLH+AA N D++ L
Sbjct: 585 -------------CKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCL 631
Query: 550 SGAHFDATNLHKQTASDL 567
GA +A +TA DL
Sbjct: 632 MGASVEALTTDGKTAEDL 649
Score = 34.7 bits (78), Expect = 0.27
Identities = 14/60 (23%), Positives = 32/60 (53%)
Query: 504 KFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQT 563
++ V +L G++ N++D ++ +PLH AA + + + L ++G + + N +T
Sbjct: 454 RYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGET 513
Score = 33.1 bits (74), Expect = 0.78
Identities = 28/102 (27%), Positives = 44/102 (43%), Gaps = 16/102 (15%)
Query: 480 KNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNN 539
K +PLH A G Y V K L E G +VN+++ + +PL A+
Sbjct: 476 KEEETPLHCAAWH-----GYYSVAK--------ALCEAGCNVNIKNREGETPLLTASARG 522
Query: 540 HPDIMNLLIKSGAHFDATNLHKQTASDLLDEK---EIAKNLI 578
+ DI+ L + GA +A + A L + E+ K L+
Sbjct: 523 YHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLL 564
Score = 33.1 bits (74), Expect = 0.78
Identities = 16/54 (29%), Positives = 25/54 (46%)
Query: 510 VTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQT 563
+ L E GAD+N D D + LH+A +++ L+ G D + H T
Sbjct: 526 IVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNT 579
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,754,215
Number of Sequences: 37866
Number of extensions: 907163
Number of successful extensions: 7131
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 357
Number of HSP's successfully gapped in prelim test: 33
Number of HSP's that attempted gapping in prelim test: 1980
Number of HSP's gapped (non-prelim): 2953
length of query: 617
length of database: 18,247,518
effective HSP length: 108
effective length of query: 509
effective length of database: 14,157,990
effective search space: 7206416910
effective search space used: 7206416910
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.