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Search of human proteins with 17402902
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|17402902 guanine nucleotide binding protein
beta-subunit-like polypeptide [Homo sapiens]
(327 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|17402902 guanine nucleotide binding protein beta-subunit-like... 676 0.0
gi|113865883 WD repeat domain 38 [Homo sapiens] 68 1e-11
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 58 1e-08
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 58 1e-08
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 58 1e-08
gi|19913369 transducin beta-like 3 [Homo sapiens] 58 1e-08
gi|5803221 WD repeat-containing protein 3 [Homo sapiens] 57 2e-08
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 57 2e-08
gi|148536855 coatomer protein complex, subunit alpha isoform 1 [... 57 2e-08
gi|148536853 coatomer protein complex, subunit alpha isoform 2 [... 57 2e-08
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 57 2e-08
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 57 2e-08
gi|32189425 WD repeat domain 69 [Homo sapiens] 57 3e-08
gi|23199987 WD repeat domain 5B [Homo sapiens] 56 4e-08
gi|21071067 TBP-associated factor 5 [Homo sapiens] 56 5e-08
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 55 9e-08
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 55 1e-07
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 55 1e-07
gi|5729852 guanine nucleotide-binding protein, beta-5 subunit is... 54 1e-07
gi|20336270 guanine nucleotide-binding protein, beta-5 subunit i... 54 1e-07
gi|8923881 WD SOCS-box protein 2 [Homo sapiens] 54 1e-07
gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [H... 54 2e-07
gi|50980309 UTP15, U3 small nucleolar ribonucleoprotein, homolog... 54 2e-07
gi|55769546 PAK1 interacting protein 1 [Homo sapiens] 54 2e-07
gi|38569484 kinesin family member 21A [Homo sapiens] 53 3e-07
gi|62234438 Notchless gene homolog isoform b [Homo sapiens] 53 3e-07
gi|7706657 cell division cycle 40 homolog [Homo sapiens] 53 4e-07
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 51 2e-06
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 51 2e-06
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 51 2e-06
>gi|17402902 guanine nucleotide binding protein beta-subunit-like
polypeptide [Homo sapiens]
Length = 327
Score = 676 bits (1744), Expect = 0.0
Identities = 327/327 (100%), Positives = 327/327 (100%)
Query: 1 MTAPCPPPPPDPQFVLRGTQSPVHALHFCEGAQAQGRPLLFSGSQSGLVHIWSLQTRRAV 60
MTAPCPPPPPDPQFVLRGTQSPVHALHFCEGAQAQGRPLLFSGSQSGLVHIWSLQTRRAV
Sbjct: 1 MTAPCPPPPPDPQFVLRGTQSPVHALHFCEGAQAQGRPLLFSGSQSGLVHIWSLQTRRAV 60
Query: 61 TTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKLCLWDLAEGRSAVVDSVCLESVGFCRSSI 120
TTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKLCLWDLAEGRSAVVDSVCLESVGFCRSSI
Sbjct: 61 TTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKLCLWDLAEGRSAVVDSVCLESVGFCRSSI 120
Query: 121 LAGGQPRWTLAVPGRGSDEVQILEMPSKTSVCALKPKADAKLGMPMCLRLWQADCSSRPL 180
LAGGQPRWTLAVPGRGSDEVQILEMPSKTSVCALKPKADAKLGMPMCLRLWQADCSSRPL
Sbjct: 121 LAGGQPRWTLAVPGRGSDEVQILEMPSKTSVCALKPKADAKLGMPMCLRLWQADCSSRPL 180
Query: 181 LLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQKARGISGSAGKALAVWSLDWQ 240
LLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQKARGISGSAGKALAVWSLDWQ
Sbjct: 181 LLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQKARGISGSAGKALAVWSLDWQ 240
Query: 241 QALQVRGTHELTNPGIAEVTIRPDRKILATAGWDHRIRVFHWRTMQPLAVLAFHSAAVQC 300
QALQVRGTHELTNPGIAEVTIRPDRKILATAGWDHRIRVFHWRTMQPLAVLAFHSAAVQC
Sbjct: 241 QALQVRGTHELTNPGIAEVTIRPDRKILATAGWDHRIRVFHWRTMQPLAVLAFHSAAVQC 300
Query: 301 VAFTADGLLAAGSKDQRISLWSLYPRA 327
VAFTADGLLAAGSKDQRISLWSLYPRA
Sbjct: 301 VAFTADGLLAAGSKDQRISLWSLYPRA 327
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 67.8 bits (164), Expect = 1e-11
Identities = 41/138 (29%), Positives = 63/138 (45%), Gaps = 6/138 (4%)
Query: 187 DGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQKARGISGSAGKALAVWSLDWQQALQVR 246
D +V LWDV+ K + H+ V + F + SG K + +W + Q L++
Sbjct: 84 DCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLL 143
Query: 247 GTHELTNPGIAEVTIRPDRKILATAGWDHRIRVFHWRTMQPLA---VLAFHSAAVQCVAF 303
H I P LAT WD + ++ R + P L HSA + C+ +
Sbjct: 144 VGHR---DSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCY 200
Query: 304 TADGLLAAGSKDQRISLW 321
+A GLLA+GS D+ I +W
Sbjct: 201 SASGLLASGSWDKTIHIW 218
Score = 63.9 bits (154), Expect = 2e-10
Identities = 41/145 (28%), Positives = 68/145 (46%), Gaps = 4/145 (2%)
Query: 180 LLLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQKARGISGSAGKALAVWSLDW 239
+LL G EDG V W+ ++ R+ H PV F S S + +W +
Sbjct: 35 MLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVAR 94
Query: 240 QQALQVRGTHELTNPGIAEVTIRPDRKILATAGWDHRIRVFHWRTMQPLAVLAFHSAAVQ 299
+ L+V H+ + + V+ PD + LA+ GWD R+ ++ ++ Q L +L H ++Q
Sbjct: 95 AKCLRVLKGHQRS---VETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQ 151
Query: 300 CVAFTAD-GLLAAGSKDQRISLWSL 323
F+ LA GS D + +W L
Sbjct: 152 SSDFSPTVNCLATGSWDSTVHIWDL 176
Score = 55.1 bits (131), Expect = 9e-08
Identities = 75/297 (25%), Positives = 119/297 (40%), Gaps = 30/297 (10%)
Query: 39 LLFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKLCLWDLA 98
+L +GS+ G V+ W ++ + + L GH G V + + P G S D + LWD+A
Sbjct: 35 MLLTGSEDGCVYGWETRSGQLLWRLGGHTGP-VKFCRFSPDGHLFASASCDCTVRLWDVA 93
Query: 99 EGRSAVVDSVCLESV-GFCRSSILAGGQPRWTLAVPGRGSDEVQILEMPSKTSVCALKPK 157
+ CL + G RS P G V + ++ S + L
Sbjct: 94 RAK-------CLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGH 146
Query: 158 ADAKLGMPMCLRLWQADCSSRPLLLA-GYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDF 216
D+ + +D S LA G D +V +WD+ E ++
Sbjct: 147 RDS---------IQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISC 197
Query: 217 DSQKARGI--SGSAGKALAVWSLDWQQAL-QVRGTHELTNPGIAEVTIRPDRKILATAGW 273
A G+ SGS K + +W L Q++G +T + + PD LA+AG+
Sbjct: 198 LCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKG--HVT--WVKSIAFSPDELWLASAGY 253
Query: 274 DHRIRVFHWRTMQPLAVLAFHSAAVQCVAFTADG-LLAAGSKDQ---RISLWSLYPR 326
++V+ T + L L AFT DG +L +G+ DQ +IS S PR
Sbjct: 254 SRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRRQISRTSKSPR 310
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 58.2 bits (139), Expect = 1e-08
Identities = 39/146 (26%), Positives = 70/146 (47%), Gaps = 6/146 (4%)
Query: 180 LLLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQKARGISGSAGKALAVWSLDW 239
L++AG + GS+ +WD+ K+ + H+ + LDF SGS + +W +
Sbjct: 77 LIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRR 136
Query: 240 QQAL-QVRGTHELTNPGIAEVTIRPDRKILATAGWDHRIRVFHWRTMQPLAVLAFHSAAV 298
+ + + RG + + + PD K LA+A DH ++++ + ++ H+ V
Sbjct: 137 KGCVFRYRGHSQ----AVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPV 192
Query: 299 QCVAF-TADGLLAAGSKDQRISLWSL 323
V F + LLA+GS D+ I W L
Sbjct: 193 NVVEFHPNEYLLASGSSDRTIRFWDL 218
Score = 51.6 bits (122), Expect = 9e-07
Identities = 60/289 (20%), Positives = 112/289 (38%), Gaps = 24/289 (8%)
Query: 33 QAQGRPLLFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKL 92
+A GR LL +G V++WS+ + +L GH + P+ +++ + +
Sbjct: 30 KASGR-LLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPE-ELIVAGSQSGSI 87
Query: 93 CLWDLAEGRSAVVDSVCLESVGFCRSSILAGGQPRWTLAVPGRGSDEVQILEMPSKTSVC 152
+WDL + ++ ++ C P G +++ ++ K V
Sbjct: 88 RVWDLEAAK--ILRTLMGHKANICSLDF----HPYGEFVASGSQDTNIKLWDIRRKGCVF 141
Query: 153 ALKPKADAKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACHEEPVM 212
+ + A CLR L + +D +V LWD++ K+ S H PV
Sbjct: 142 RYRGHSQAV----RCLRF----SPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVN 193
Query: 213 DLDFDSQKARGISGSAGKALAVWSLDWQQALQ-VRGTHELTNPG-IAEVTIRPDRKILAT 270
++F + SGS+ + + W L+ Q + + G PG + V PD L
Sbjct: 194 VVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEG-----EPGPVRSVLFNPDGCCL-Y 247
Query: 271 AGWDHRIRVFHWRTMQPLAVLAFHSAAVQCVAFTADGLLAAGSKDQRIS 319
+G +RV+ W + V+ + V +A D L+ +S
Sbjct: 248 SGCQDSLRVYGWEPERCFDVVLVNWGKVADLAICNDQLIGVAFSQSNVS 296
Score = 31.2 bits (69), Expect = 1.3
Identities = 19/61 (31%), Positives = 34/61 (55%), Gaps = 5/61 (8%)
Query: 266 KILATAGWDHRIRVFHWRTMQPLAVLAF--HSAAVQCVAF-TADGLLAAGSKDQRISLWS 322
++LAT G D R+ + W +P +++ H++ V+ V T + L+ AGS+ I +W
Sbjct: 34 RLLATGGDDCRVNL--WSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWD 91
Query: 323 L 323
L
Sbjct: 92 L 92
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 58.2 bits (139), Expect = 1e-08
Identities = 45/146 (30%), Positives = 63/146 (43%), Gaps = 8/146 (5%)
Query: 181 LLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQKARGISGSAGKALAVWSLDWQ 240
LL+ ED S+ WD+ H PV DLD SGS + +WS D
Sbjct: 357 LLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRT 416
Query: 241 QALQVRGTHELTNPGIAEVTIRPDRKILATAGWDHRIRVFHWRTMQPLAVLAF--HSAAV 298
L++ H + V P+ LAT D +R+ W Q +V F H V
Sbjct: 417 YPLRIYAGH---LADVDCVKFHPNSNYLATGSTDKTVRL--WSAQQGNSVRLFTGHRGPV 471
Query: 299 QCVAFTADG-LLAAGSKDQRISLWSL 323
+AF+ +G LA+ +DQR+ LW L
Sbjct: 472 LSLAFSPNGKYLASAGEDQRLKLWDL 497
Score = 47.0 bits (110), Expect = 2e-05
Identities = 41/156 (26%), Positives = 65/156 (41%), Gaps = 5/156 (3%)
Query: 170 LWQADCSSRPLLLA-GYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQKARGISGSA 228
+W D S L A G D + LW A H V + F +GS
Sbjct: 387 VWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGST 446
Query: 229 GKALAVWSLDWQQALQVRGTHELTNPGIAEVTIRPDRKILATAGWDHRIRVFHWRTMQPL 288
K + +WS QQ VR P + + P+ K LA+AG D R++++ +
Sbjct: 447 DKTVRLWSA--QQGNSVRLFTGHRGP-VLSLAFSPNGKYLASAGEDQRLKLWDLASGTLY 503
Query: 289 AVLAFHSAAVQCVAFTAD-GLLAAGSKDQRISLWSL 323
L H+ + + F+ D GL+A+ S D + +W +
Sbjct: 504 KELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDI 539
Score = 45.4 bits (106), Expect = 7e-05
Identities = 25/61 (40%), Positives = 32/61 (52%), Gaps = 1/61 (1%)
Query: 40 LFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKLCLWDLAE 99
L +GS V +WS Q +V GH G ++ L P G+ L S G D +L LWDLA
Sbjct: 441 LATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLS-LAFSPNGKYLASAGEDQRLKLWDLAS 499
Query: 100 G 100
G
Sbjct: 500 G 500
Score = 36.2 bits (82), Expect = 0.041
Identities = 26/103 (25%), Positives = 39/103 (37%), Gaps = 3/103 (2%)
Query: 181 LLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQKARGISGSAGKALAVWSLDWQ 240
L G D +V LW + H PV+ L F S + L +W L
Sbjct: 441 LATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASG 500
Query: 241 QALQVRGTHELTNPGIAEVTIRPDRKILATAGWDHRIRVFHWR 283
+ H I +T PD ++A+A D+ +RV+ R
Sbjct: 501 TLYKELRGH---TDNITSLTFSPDSGLIASASMDNSVRVWDIR 540
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 58.2 bits (139), Expect = 1e-08
Identities = 77/340 (22%), Positives = 124/340 (36%), Gaps = 81/340 (23%)
Query: 40 LFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKLCLWDLAE 99
L SGS V W L T T GH V + P GR+L S ++ ++ LWD +
Sbjct: 129 LASGSGDTTVRFWDLSTETPHFTCKGHR-HWVLSISWSPDGRKLASGCKNGQILLWDPST 187
Query: 100 GRSAVVDSVCLESVGFCRSSILAGGQPRWTLAV---PGRGSDEVQILEMPSKTSVCALKP 156
G+ G +W + P + E + + SK +
Sbjct: 188 GKQV---------------GRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWD 232
Query: 157 KADAKLGMPM--------CLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACHE 208
+ + CLR W D LL + +D ++ +W + +C + H
Sbjct: 233 TTAGRCERILTGHTQSVTCLR-WGGD----GLLYSASQDRTIKVWRAHDGVLCRTLQGHG 287
Query: 209 EPVMDLDFDSQKA------------------------------------------RGISG 226
V + + A R +SG
Sbjct: 288 HWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSG 347
Query: 227 SAGKALAVWSL--DWQQALQVRGTHELTNPGIAEVTIRPDRKILATAGWDHRIRVFHWRT 284
S L +WS D + ++ G L N +V PD +I+A+A +D I+++ RT
Sbjct: 348 SDDFTLFLWSPAEDKKPLTRMTGHQALIN----QVLFSPDSRIVASASFDKSIKLWDGRT 403
Query: 285 MQPLAVLAFHSAAVQCVAFTADG-LLAAGSKDQRISLWSL 323
+ LA L H AAV +A++AD LL +GS D + +W +
Sbjct: 404 GKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDV 443
Score = 41.6 bits (96), Expect = 0.001
Identities = 21/65 (32%), Positives = 32/65 (49%), Gaps = 3/65 (4%)
Query: 171 WQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQKARGISGSAGK 230
W AD LL++G D ++ +WDV QK+ + H + V +D+ R SG K
Sbjct: 422 WSADSR---LLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDK 478
Query: 231 ALAVW 235
L +W
Sbjct: 479 CLRIW 483
Score = 39.3 bits (90), Expect = 0.005
Identities = 60/254 (23%), Positives = 100/254 (39%), Gaps = 31/254 (12%)
Query: 36 GRPLLFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKLCLW 95
G LL+S SQ + +W TL GHG W+ T+ LS L+ +
Sbjct: 256 GDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGH----WVNTMA-----LSTDYALRTGAF 306
Query: 96 DLAEGRSAVVDSVC----LESVGFCRSSILAGGQPRWTLAVPGRGSDEVQI-LEMPSKTS 150
+ AE D L+ R +++ G P ++ GSD+ + L P++
Sbjct: 307 EPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVS----GSDDFTLFLWSPAED- 361
Query: 151 VCALKPKADAKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACHEEP 210
K G + SR + A + D S+ LWD K + + H
Sbjct: 362 ----KKPLTRMTGHQALINQVLFSPDSRIVASASF-DKSIKLWDGRTGKYLASLRGHVAA 416
Query: 211 VMDLDFDSQKARGISGSAGKALAVWSLDWQQ-ALQVRGTHELTNPGIAEVTIRPDRKILA 269
V + + + +SGS+ L VW + Q+ A+ + G + + V PD + +A
Sbjct: 417 VYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHAD----EVYAVDWSPDGQRVA 472
Query: 270 TAGWDHRIRVFHWR 283
+ G D +R+ WR
Sbjct: 473 SGGKDKCLRI--WR 484
>gi|19913369 transducin beta-like 3 [Homo sapiens]
Length = 808
Score = 58.2 bits (139), Expect = 1e-08
Identities = 73/328 (22%), Positives = 128/328 (39%), Gaps = 38/328 (11%)
Query: 17 RGTQSPVHALHFCEGAQAQGRPLLFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQT 76
RG+ VH + F R LLFS + + +WSLQ R + L H VT L
Sbjct: 148 RGSPGVVHLVAFHPDPT---RLLLFSSATDAAIRVWSLQDRSCLAVLTAH-YSAVTSLAF 203
Query: 77 LPQGRQLLSQGRDLKLCLWDLAEGRSAVVDSVCLESVGFCRSSILAGGQPRWTLAVPGRG 136
G +LS GRD +WDL ++ V ESV +++L +P L V G
Sbjct: 204 SADGHTMLSSGRDKICIIWDLQSCQATRTVPV-FESV---EAAVLLPEEPVSQLGVKSPG 259
Query: 137 ------SDEVQILEMPSKTSVCALKPKADAKLGMPMCLRLWQADCS---SRPLLLAGYED 187
D+ + + + C G + C+ + ++L D
Sbjct: 260 LYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQEL------THCTLAHTAGVVLTATAD 313
Query: 188 GSVVLWDVSEQKVCSRIACHEEPVMDLDF-DSQKARGISGSAGKALAVWSLDWQQALQVR 246
+++L++ ++ + A + E V+D+ F + + + S L V+ L +
Sbjct: 314 HNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQILH 373
Query: 247 GTHELTNPGIAEVTIRPDRKILATAGWDHRIRVFHWRTMQPLAVLAF-------HSAAVQ 299
G ++ + + + + A+ D +R+ WR + V+ HS
Sbjct: 374 GHTDI----VLALDVFRKGWLFASCAKDQSVRI--WRMNKAGQVMCVAQGSGHTHSVGTV 427
Query: 300 CVAFTADGLLAAGSKDQRISLWSLYPRA 327
C + + L GS+D + LW L P+A
Sbjct: 428 CCSRLKESFLVTGSQDCTVKLWPL-PKA 454
Score = 57.0 bits (136), Expect = 2e-08
Identities = 50/156 (32%), Positives = 75/156 (48%), Gaps = 23/156 (14%)
Query: 176 SSRPLLLA--GYEDGSVV-LWDVSEQKVCSRIACHEEPVMDLDFDSQKARGISGSAGKAL 232
+SR LLLA +++GSV LW A H PV + FD +G A+
Sbjct: 84 ASRALLLAQWAWQEGSVTRLWK----------AIHTAPVATMAFDPTSTLLATGGCDGAV 133
Query: 233 AVWSLDWQQALQVRGTHELT-NPGIAE-VTIRPD--RKILATAGWDHRIRVFHWRTMQPL 288
VW + ++ GTH +PG+ V PD R +L ++ D IRV+ + L
Sbjct: 134 RVWDI-----VRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQDRSCL 188
Query: 289 AVLAFHSAAVQCVAFTADG-LLAAGSKDQRISLWSL 323
AVL H +AV +AF+ADG + + +D+ +W L
Sbjct: 189 AVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDL 224
Score = 45.8 bits (107), Expect = 5e-05
Identities = 44/169 (26%), Positives = 72/169 (42%), Gaps = 24/169 (14%)
Query: 175 CSSR---PLLLAGYEDGSVVLWDVSEQKVCSRIA---------------CHEEPVMDLDF 216
C SR L+ G +D +V LW + + + A CH++ + +
Sbjct: 428 CCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAI 487
Query: 217 DSQKARGISGSAGKALAVWSLDWQQALQVRGTHELTNPGIAEVTIRPDRKILATAGWDHR 276
+GS + +W+L Q L V H G+ V P ++LATA D
Sbjct: 488 APNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRR---GLWCVQFSPMDQVLATASADGT 544
Query: 277 IRVFHWRTMQPLAVLAFHSAAVQCVAFTADG--LLAAGSKDQRISLWSL 323
I+++ + L H A+V VAF + G LL++GS D + LW++
Sbjct: 545 IKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGS-DGLVKLWTI 592
Score = 38.5 bits (88), Expect = 0.008
Identities = 33/125 (26%), Positives = 51/125 (40%), Gaps = 9/125 (7%)
Query: 208 EEPVMDLDFDSQKARGISGSAGKALAVWSLDWQQALQVRGTHELTNPGIAEVTIRPDRKI 267
+E + D ++ S LA W+ WQ+ R + +A + P +
Sbjct: 66 QEDITAFDLSPDNEVLVTASRALLLAQWA--WQEGSVTRLWKAIHTAPVATMAFDPTSTL 123
Query: 268 LATAGWDHRIRVFHWRTMQPLAVLAFHSA--AVQCVAFTADG---LLAAGSKDQRISLWS 322
LAT G D +RV W ++ F + V VAF D LL + + D I +WS
Sbjct: 124 LATGGCDGAVRV--WDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWS 181
Query: 323 LYPRA 327
L R+
Sbjct: 182 LQDRS 186
Score = 36.2 bits (82), Expect = 0.041
Identities = 52/210 (24%), Positives = 76/210 (36%), Gaps = 24/210 (11%)
Query: 8 PPPDPQFVLRGTQSPVHALHFCEGAQAQGRPLLFSGSQSGLVHIWSLQTRRAVTTLDGH- 66
P P + T H A A LL +GSQ +W+L + + GH
Sbjct: 462 PDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHR 521
Query: 67 -GGQCVTWLQTLPQGRQLLSQGRDLKLCLWDLAEGRSAVVDSVCLESV-GFCRSSILAGG 124
G CV Q P + L + D + LW A+ D CL++ G S +
Sbjct: 522 RGLWCV---QFSPMDQVLATASADGTIKLW-------ALQDFSCLKTFEGHDASVLKVAF 571
Query: 125 QPRWTLAVPGRGSDEVQILEMPSKTSVCALKPKADAKLGMPMCLRLWQADCSS-RPLLLA 183
R T + V++ + + V L D ++W CS L
Sbjct: 572 VSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHED---------KVWGLHCSRLDDHALT 622
Query: 184 GYEDGSVVLW-DVSEQKVCSRIACHEEPVM 212
G D V+LW DV+E + A EE V+
Sbjct: 623 GASDSRVILWKDVTEAEQAEEQARQEEQVV 652
Score = 29.6 bits (65), Expect = 3.8
Identities = 17/82 (20%), Positives = 36/82 (43%), Gaps = 1/82 (1%)
Query: 170 LWQADCSSRPLLLA-GYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQKARGISGSA 228
LW S +LA DG++ LW + + H+ V+ + F S+ + +S +
Sbjct: 524 LWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGS 583
Query: 229 GKALAVWSLDWQQALQVRGTHE 250
+ +W++ + ++ HE
Sbjct: 584 DGLVKLWTIKNNECVRTLDAHE 605
Score = 29.3 bits (64), Expect = 5.0
Identities = 13/55 (23%), Positives = 24/55 (43%)
Query: 181 LLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQKARGISGSAGKALAVW 235
LL+ DG V LW + + + HE+ V L ++G++ + +W
Sbjct: 578 LLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILW 632
>gi|5803221 WD repeat-containing protein 3 [Homo sapiens]
Length = 943
Score = 57.4 bits (137), Expect = 2e-08
Identities = 36/152 (23%), Positives = 74/152 (48%), Gaps = 9/152 (5%)
Query: 181 LLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQKARGISGSAGKALAVWSLDW- 239
++ G + G + L+D++ + I H+ + + + ++G A K++ W +
Sbjct: 469 VVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELV 528
Query: 240 ------QQALQVRGTHELT-NPGIAEVTIRPDRKILATAGWDHRIRVFHWRTMQPLAVLA 292
Q+ L V+ T L + + V+ P++K+LA + D +++F+ T++ L
Sbjct: 529 KDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLY 588
Query: 293 FHSAAVQCVAFTADG-LLAAGSKDQRISLWSL 323
H V C+ + DG L+A GS D+ + +W L
Sbjct: 589 GHKLPVICMDISHDGALIATGSADRNVKIWGL 620
Score = 55.8 bits (133), Expect = 5e-08
Identities = 68/322 (21%), Positives = 129/322 (40%), Gaps = 22/322 (6%)
Query: 4 PCPPPPPDPQFVLRGTQSPVHALHFCEGAQAQGRPLLFSGSQSGLVHIWSLQTRRAVTTL 63
P P P + + G +S V L F A +L + + S + IW+ T + + T+
Sbjct: 399 PTPQPVRTSRITIGGHRSDVRTLSFSSDNIA----VLSAAADS--IKIWNRSTLQCIRTM 452
Query: 64 DGHGGQCVTWLQTLPQGRQLLSQGRDLKLCLWDLAEGRSAVVDSVCLESVGFCRSSILAG 123
C ++ P RQ++ + KL L+DLA G +++++ S+
Sbjct: 453 TCEYALCSFFV---PGDRQVVIGTKTGKLQLYDLASGN--LLETIDAHDGALWSMSL--- 504
Query: 124 GQPRWTLAVPGRGSDEVQILEMPSKTSVCALKPKADAKLGMPMCLR---LWQADCSSRPL 180
P V G V+ + + + + K + L L + ++ L
Sbjct: 505 -SPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKL 563
Query: 181 LLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQKARGISGSAGKALAVWSLDWQ 240
L D +V ++ V K + H+ PV+ +D A +GSA + + +W LD+
Sbjct: 564 LAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFG 623
Query: 241 QALQVRGTHELTNPGIAEVTIRPDRKILATAGWDHRIRVFHWRTMQPLAVLAFHSAAVQC 300
+ H+ + + P + TAG DH+I+ + + + L H + C
Sbjct: 624 DCHKSLFAHD---DSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWC 680
Query: 301 VAFTADG-LLAAGSKDQRISLW 321
+A + G + + S D+ + LW
Sbjct: 681 LAVSPSGDYVVSSSHDKSLRLW 702
Score = 38.5 bits (88), Expect = 0.008
Identities = 44/196 (22%), Positives = 78/196 (39%), Gaps = 15/196 (7%)
Query: 49 VHIWSLQTRRAVTTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKLCLWDLAEGRSAVVDSV 108
V IW L+ + L G Q VT L P G L D + ++ L G V +
Sbjct: 47 VFIWDLRKGEKILILQGLK-QEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNG 105
Query: 109 CLESVGFCRSSILAGGQPRWTLAVPGRGSDEVQILEMPSKTSVCALKPKADAKLGMPMCL 168
++ + L G G ++ + ++ +++ + LK DA + + L
Sbjct: 106 HKAAITTLKYDQLGGR------LASGSKDTDIIVWDVINESGLYRLKGHKDA-ITQALFL 158
Query: 169 RLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQKARGISGSA 228
R + LL+ +D V WD+ Q + H V L S++ R I+G++
Sbjct: 159 R-------EKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGAS 211
Query: 229 GKALAVWSLDWQQALQ 244
L VW + + Q ++
Sbjct: 212 DSELRVWDIAYLQEIE 227
Score = 35.4 bits (80), Expect = 0.070
Identities = 23/108 (21%), Positives = 45/108 (41%), Gaps = 3/108 (2%)
Query: 181 LLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQKARGISGSAGKALAVWSLDWQ 240
L +G +D +++WDV + R+ H++ + F +K ++ + W LD Q
Sbjct: 122 LASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQ 181
Query: 241 QALQVRGTHELTNPGIAEVTIRPDRKILATAGWDHRIRVFHWRTMQPL 288
+ H G+ + + K L T D +RV+ +Q +
Sbjct: 182 HCFKTMVGHRTEVWGL---VLLSEEKRLITGASDSELRVWDIAYLQEI 226
Score = 32.7 bits (73), Expect = 0.45
Identities = 18/60 (30%), Positives = 32/60 (53%), Gaps = 1/60 (1%)
Query: 39 LLFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKLCLWDLA 98
LL + + +V W L T+ T+ GH + V L L + ++L++ D +L +WD+A
Sbjct: 163 LLVTSGKDTMVKWWDLDTQHCFKTMVGHRTE-VWGLVLLSEEKRLITGASDSELRVWDIA 221
Score = 30.4 bits (67), Expect = 2.2
Identities = 30/110 (27%), Positives = 50/110 (45%), Gaps = 12/110 (10%)
Query: 219 QKARGISGSAGKALAVWSL-DWQQALQVRGTHELTNPGIAEVTI---RPDRKILATAGWD 274
+K R ++ A + + +W L ++ L ++G + EVT PD LA D
Sbjct: 34 EKGRYVAVPACEHVFIWDLRKGEKILILQGLKQ-------EVTCLCPSPDGLHLAVGYED 86
Query: 275 HRIRVFHWRTMQPLAVLAFHSAAVQCVAFTA-DGLLAAGSKDQRISLWSL 323
IR+F + + H AA+ + + G LA+GSKD I +W +
Sbjct: 87 GSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDV 136
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 57.4 bits (137), Expect = 2e-08
Identities = 46/176 (26%), Positives = 79/176 (44%), Gaps = 12/176 (6%)
Query: 148 KTSVCALKPKADAKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACH 207
KTS+ LK G +CL+ +++ G D +V +WDV+ +V + + H
Sbjct: 267 KTSLECLKVLT-GHTGSVLCLQY------DERVIVTGSSDSTVRVWDVNTGEVLNTLIHH 319
Query: 208 EEPVMDLDFDSQKARGISGSAGKALAVWSLDWQQALQVRGTHELTNPGIAEVTIRPDRKI 267
E V+ L F + ++ S +++AVW D A + L A + D K
Sbjct: 320 NEAVLHLRFSN--GLMVTCSKDRSIAVW--DMASATDITLRRVLVGHRAAVNVVDFDDKY 375
Query: 268 LATAGWDHRIRVFHWRTMQPLAVLAFHSAAVQCVAFTADGLLAAGSKDQRISLWSL 323
+ +A D I+V+ T + + L H + C+ + D L+ +GS D I LW +
Sbjct: 376 IVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQY-RDRLVVSGSSDNTIRLWDI 430
Score = 42.0 bits (97), Expect = 7e-04
Identities = 49/209 (23%), Positives = 88/209 (42%), Gaps = 24/209 (11%)
Query: 39 LLFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKLCLWDLA 98
++ +GS V +W + T + TL H + V L+ +++ +D + +WD+A
Sbjct: 292 VIVTGSSDSTVRVWDVNTGEVLNTLIHHN-EAVLHLRF--SNGLMVTCSKDRSIAVWDMA 348
Query: 99 EGRSAVVDSVCLESVGFCRSSILAGGQPRWTLAVPGRGSDEVQILEMPSKTSVCALKPKA 158
+ V VG + + ++ ++ G + +V TS C
Sbjct: 349 SATDITLRRVL---VGHRAAVNVVDFDDKYIVSASGDRTIKVW------STSTCEFVRTL 399
Query: 159 DAKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRI-ACHEEPVMDLDFD 217
+ CL+ L+++G D ++ LWD+ E C R+ HEE V + FD
Sbjct: 400 NGHKRGIACLQYRDR------LVVSGSSDNTIRLWDI-ECGACLRVLEGHEELVRCIRFD 452
Query: 218 SQKARGISGSAGKALAVWSLDWQQALQVR 246
++ R +SG+ + VW D Q AL R
Sbjct: 453 NK--RIVSGAYDGKIKVW--DLQAALDPR 477
Score = 34.7 bits (78), Expect = 0.12
Identities = 57/292 (19%), Positives = 114/292 (39%), Gaps = 37/292 (12%)
Query: 40 LFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKLCLWDLAE 99
+ SG + + IW + + L GH G V LQ R +++ D + +WD+
Sbjct: 253 IISGLRDNSIKIWDKTSLECLKVLTGHTGS-VLCLQY--DERVIVTGSSDSTVRVWDVNT 309
Query: 100 GRSAVVDSVCLESVGFCRSSILAGGQPRWTLAVPGRGSDEVQILEMPSKTSVCALKPKAD 159
G V++++ + G L V + + +M S T + +
Sbjct: 310 GE--VLNTLIHHNEAVLHLRFSNG------LMVTCSKDRSIAVWDMASATDITLRRVLVG 361
Query: 160 AKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQ 219
+ + + D + ++ A D ++ +W S + + H+ + L + +
Sbjct: 362 HRAAVNV------VDFDDKYIVSAS-GDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDR 414
Query: 220 KARGISGSAGKALAVWSLDWQQALQV-RGTHELTNPGIAEVTIRPDRKILATAGWDHRIR 278
+SGS+ + +W ++ L+V G EL IR D K + + +D +I+
Sbjct: 415 LV--VSGSSDNTIRLWDIECGACLRVLEGHEELVR------CIRFDNKRIVSGAYDGKIK 466
Query: 279 VFHWR-TMQP--------LAVLAFHSAAVQCVAFTADGLLAAGSKDQRISLW 321
V+ + + P L L HS V + F ++++ S D I +W
Sbjct: 467 VWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISS-SHDDTILIW 517
>gi|148536855 coatomer protein complex, subunit alpha isoform 1
[Homo sapiens]
Length = 1233
Score = 57.4 bits (137), Expect = 2e-08
Identities = 37/147 (25%), Positives = 65/147 (44%), Gaps = 4/147 (2%)
Query: 178 RPLLLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQKARGISGSAGKALAVWSL 237
RP +L +G + LWD + + H+ PV +DF Q+ +SG + VW+
Sbjct: 21 RPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNY 80
Query: 238 DWQQALQVRGTHELTNPGIAEVTIRPDRKILATAGWDHRIRVFHWRTMQPLAVLAFHSAA 297
++ L H I + + +A D IRV++W++ + VL H+
Sbjct: 81 KLRRCLFTLLGH---LDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGHNHY 137
Query: 298 VQCVAF-TADGLLAAGSKDQRISLWSL 323
V C F + L+ + S DQ + +W +
Sbjct: 138 VMCAQFHPTEDLVVSASLDQTVRVWDI 164
Score = 39.7 bits (91), Expect = 0.004
Identities = 45/209 (21%), Positives = 77/209 (36%), Gaps = 31/209 (14%)
Query: 38 PLLFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKLCLWDL 97
P + S S + +W+ Q+R V L GH V Q P ++S D + +WD+
Sbjct: 106 PWILSASDDQTIRVWNWQSRTCVCVLTGHN-HYVMCAQFHPTEDLVVSASLDQTVRVWDI 164
Query: 98 AEGRSAVVDSVCLESVGFCRSSILAGGQPRWTLAVPGRGSDEVQILEMPSKTSVCALKPK 157
+ R + +ES RG V + L+
Sbjct: 165 SGLRKKNLSPGAVES--------------------DVRGITGVDLFGTTDAVVKHVLEGH 204
Query: 158 ADAKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIAC--HEEPVMDLD 215
D + W A + PL+++G +D V +W ++E K C H V
Sbjct: 205 -DRGVN-------WAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAV 256
Query: 216 FDSQKARGISGSAGKALAVWSLDWQQALQ 244
F ++ +S S K++ VW + + +Q
Sbjct: 257 FHPRQELILSNSEDKSIRVWDMSKRTGVQ 285
Score = 35.8 bits (81), Expect = 0.053
Identities = 59/297 (19%), Positives = 109/297 (36%), Gaps = 43/297 (14%)
Query: 37 RPLLFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKLCLWD 96
RP + + +G++ +W + + D H G V + Q +S G D K+ +W+
Sbjct: 21 RPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGP-VRGIDFHKQQPLFVSGGDDYKIKVWN 79
Query: 97 LAEGRSAVVDSVCLESVGFCRSSILAGGQPRWTLAVPGRGSDEVQILEMPSKTSVCALKP 156
R L + + R++ P W L+ +++ S+T VC L
Sbjct: 80 YKLRRCLF---TLLGHLDYIRTTFFHHEYP-WILS--ASDDQTIRVWNWQSRTCVCVL-- 131
Query: 157 KADAKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVS--EQKVCSRIACHEEPVMDL 214
MC + + L+++ D +V +WD+S +K S A +
Sbjct: 132 --TGHNHYVMCAQFHPTE----DLVVSASLDQTVRVWDISGLRKKNLSPGAVESD----- 180
Query: 215 DFDSQKARGISGSAGKALAVWSLDWQQALQVRGTHELTNPGIAEVTIRPDRKILATAGWD 274
RGI+G L V+ E + G+ P ++ + D
Sbjct: 181 ------VRGITGV--------DLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADD 226
Query: 275 HRIRVFHWRTMQPLA----VLAFHSAAVQCVAF-TADGLLAAGSKDQRISLWSLYPR 326
++++ WR + A H V C F L+ + S+D+ I +W + R
Sbjct: 227 RQVKI--WRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKR 281
>gi|148536853 coatomer protein complex, subunit alpha isoform 2
[Homo sapiens]
Length = 1224
Score = 57.4 bits (137), Expect = 2e-08
Identities = 37/147 (25%), Positives = 65/147 (44%), Gaps = 4/147 (2%)
Query: 178 RPLLLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQKARGISGSAGKALAVWSL 237
RP +L +G + LWD + + H+ PV +DF Q+ +SG + VW+
Sbjct: 21 RPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNY 80
Query: 238 DWQQALQVRGTHELTNPGIAEVTIRPDRKILATAGWDHRIRVFHWRTMQPLAVLAFHSAA 297
++ L H I + + +A D IRV++W++ + VL H+
Sbjct: 81 KLRRCLFTLLGH---LDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGHNHY 137
Query: 298 VQCVAF-TADGLLAAGSKDQRISLWSL 323
V C F + L+ + S DQ + +W +
Sbjct: 138 VMCAQFHPTEDLVVSASLDQTVRVWDI 164
Score = 39.7 bits (91), Expect = 0.004
Identities = 45/209 (21%), Positives = 77/209 (36%), Gaps = 31/209 (14%)
Query: 38 PLLFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKLCLWDL 97
P + S S + +W+ Q+R V L GH V Q P ++S D + +WD+
Sbjct: 106 PWILSASDDQTIRVWNWQSRTCVCVLTGHN-HYVMCAQFHPTEDLVVSASLDQTVRVWDI 164
Query: 98 AEGRSAVVDSVCLESVGFCRSSILAGGQPRWTLAVPGRGSDEVQILEMPSKTSVCALKPK 157
+ R + +ES RG V + L+
Sbjct: 165 SGLRKKNLSPGAVES--------------------DVRGITGVDLFGTTDAVVKHVLEGH 204
Query: 158 ADAKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIAC--HEEPVMDLD 215
D + W A + PL+++G +D V +W ++E K C H V
Sbjct: 205 -DRGVN-------WAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAV 256
Query: 216 FDSQKARGISGSAGKALAVWSLDWQQALQ 244
F ++ +S S K++ VW + + +Q
Sbjct: 257 FHPRQELILSNSEDKSIRVWDMSKRTGVQ 285
Score = 35.8 bits (81), Expect = 0.053
Identities = 59/297 (19%), Positives = 109/297 (36%), Gaps = 43/297 (14%)
Query: 37 RPLLFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKLCLWD 96
RP + + +G++ +W + + D H G V + Q +S G D K+ +W+
Sbjct: 21 RPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGP-VRGIDFHKQQPLFVSGGDDYKIKVWN 79
Query: 97 LAEGRSAVVDSVCLESVGFCRSSILAGGQPRWTLAVPGRGSDEVQILEMPSKTSVCALKP 156
R L + + R++ P W L+ +++ S+T VC L
Sbjct: 80 YKLRRCLF---TLLGHLDYIRTTFFHHEYP-WILS--ASDDQTIRVWNWQSRTCVCVL-- 131
Query: 157 KADAKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVS--EQKVCSRIACHEEPVMDL 214
MC + + L+++ D +V +WD+S +K S A +
Sbjct: 132 --TGHNHYVMCAQFHPTE----DLVVSASLDQTVRVWDISGLRKKNLSPGAVESD----- 180
Query: 215 DFDSQKARGISGSAGKALAVWSLDWQQALQVRGTHELTNPGIAEVTIRPDRKILATAGWD 274
RGI+G L V+ E + G+ P ++ + D
Sbjct: 181 ------VRGITGV--------DLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADD 226
Query: 275 HRIRVFHWRTMQPLA----VLAFHSAAVQCVAF-TADGLLAAGSKDQRISLWSLYPR 326
++++ WR + A H V C F L+ + S+D+ I +W + R
Sbjct: 227 RQVKI--WRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKR 281
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 57.4 bits (137), Expect = 2e-08
Identities = 46/176 (26%), Positives = 79/176 (44%), Gaps = 12/176 (6%)
Query: 148 KTSVCALKPKADAKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACH 207
KTS+ LK G +CL+ +++ G D +V +WDV+ +V + + H
Sbjct: 233 KTSLECLKVLT-GHTGSVLCLQY------DERVIVTGSSDSTVRVWDVNTGEVLNTLIHH 285
Query: 208 EEPVMDLDFDSQKARGISGSAGKALAVWSLDWQQALQVRGTHELTNPGIAEVTIRPDRKI 267
E V+ L F + ++ S +++AVW D A + L A + D K
Sbjct: 286 NEAVLHLRFSN--GLMVTCSKDRSIAVW--DMASATDITLRRVLVGHRAAVNVVDFDDKY 341
Query: 268 LATAGWDHRIRVFHWRTMQPLAVLAFHSAAVQCVAFTADGLLAAGSKDQRISLWSL 323
+ +A D I+V+ T + + L H + C+ + D L+ +GS D I LW +
Sbjct: 342 IVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQY-RDRLVVSGSSDNTIRLWDI 396
Score = 42.0 bits (97), Expect = 7e-04
Identities = 49/209 (23%), Positives = 88/209 (42%), Gaps = 24/209 (11%)
Query: 39 LLFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKLCLWDLA 98
++ +GS V +W + T + TL H + V L+ +++ +D + +WD+A
Sbjct: 258 VIVTGSSDSTVRVWDVNTGEVLNTLIHHN-EAVLHLRF--SNGLMVTCSKDRSIAVWDMA 314
Query: 99 EGRSAVVDSVCLESVGFCRSSILAGGQPRWTLAVPGRGSDEVQILEMPSKTSVCALKPKA 158
+ V VG + + ++ ++ G + +V TS C
Sbjct: 315 SATDITLRRVL---VGHRAAVNVVDFDDKYIVSASGDRTIKVW------STSTCEFVRTL 365
Query: 159 DAKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRI-ACHEEPVMDLDFD 217
+ CL+ L+++G D ++ LWD+ E C R+ HEE V + FD
Sbjct: 366 NGHKRGIACLQYRDR------LVVSGSSDNTIRLWDI-ECGACLRVLEGHEELVRCIRFD 418
Query: 218 SQKARGISGSAGKALAVWSLDWQQALQVR 246
++ R +SG+ + VW D Q AL R
Sbjct: 419 NK--RIVSGAYDGKIKVW--DLQAALDPR 443
Score = 34.7 bits (78), Expect = 0.12
Identities = 57/292 (19%), Positives = 114/292 (39%), Gaps = 37/292 (12%)
Query: 40 LFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKLCLWDLAE 99
+ SG + + IW + + L GH G V LQ R +++ D + +WD+
Sbjct: 219 IISGLRDNSIKIWDKTSLECLKVLTGHTGS-VLCLQY--DERVIVTGSSDSTVRVWDVNT 275
Query: 100 GRSAVVDSVCLESVGFCRSSILAGGQPRWTLAVPGRGSDEVQILEMPSKTSVCALKPKAD 159
G V++++ + G L V + + +M S T + +
Sbjct: 276 GE--VLNTLIHHNEAVLHLRFSNG------LMVTCSKDRSIAVWDMASATDITLRRVLVG 327
Query: 160 AKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQ 219
+ + + D + ++ A D ++ +W S + + H+ + L + +
Sbjct: 328 HRAAVNV------VDFDDKYIVSAS-GDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDR 380
Query: 220 KARGISGSAGKALAVWSLDWQQALQV-RGTHELTNPGIAEVTIRPDRKILATAGWDHRIR 278
+SGS+ + +W ++ L+V G EL IR D K + + +D +I+
Sbjct: 381 LV--VSGSSDNTIRLWDIECGACLRVLEGHEELVR------CIRFDNKRIVSGAYDGKIK 432
Query: 279 VFHWR-TMQP--------LAVLAFHSAAVQCVAFTADGLLAAGSKDQRISLW 321
V+ + + P L L HS V + F ++++ S D I +W
Sbjct: 433 VWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISS-SHDDTILIW 483
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 57.4 bits (137), Expect = 2e-08
Identities = 46/176 (26%), Positives = 79/176 (44%), Gaps = 12/176 (6%)
Query: 148 KTSVCALKPKADAKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACH 207
KTS+ LK G +CL+ +++ G D +V +WDV+ +V + + H
Sbjct: 254 KTSLECLKVLT-GHTGSVLCLQY------DERVIVTGSSDSTVRVWDVNTGEVLNTLIHH 306
Query: 208 EEPVMDLDFDSQKARGISGSAGKALAVWSLDWQQALQVRGTHELTNPGIAEVTIRPDRKI 267
E V+ L F + ++ S +++AVW D A + L A + D K
Sbjct: 307 NEAVLHLRFSN--GLMVTCSKDRSIAVW--DMASATDITLRRVLVGHRAAVNVVDFDDKY 362
Query: 268 LATAGWDHRIRVFHWRTMQPLAVLAFHSAAVQCVAFTADGLLAAGSKDQRISLWSL 323
+ +A D I+V+ T + + L H + C+ + D L+ +GS D I LW +
Sbjct: 363 IVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQY-RDRLVVSGSSDNTIRLWDI 417
Score = 42.0 bits (97), Expect = 7e-04
Identities = 49/209 (23%), Positives = 88/209 (42%), Gaps = 24/209 (11%)
Query: 39 LLFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKLCLWDLA 98
++ +GS V +W + T + TL H + V L+ +++ +D + +WD+A
Sbjct: 279 VIVTGSSDSTVRVWDVNTGEVLNTLIHHN-EAVLHLRF--SNGLMVTCSKDRSIAVWDMA 335
Query: 99 EGRSAVVDSVCLESVGFCRSSILAGGQPRWTLAVPGRGSDEVQILEMPSKTSVCALKPKA 158
+ V VG + + ++ ++ G + +V TS C
Sbjct: 336 SATDITLRRVL---VGHRAAVNVVDFDDKYIVSASGDRTIKVW------STSTCEFVRTL 386
Query: 159 DAKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRI-ACHEEPVMDLDFD 217
+ CL+ L+++G D ++ LWD+ E C R+ HEE V + FD
Sbjct: 387 NGHKRGIACLQYRDR------LVVSGSSDNTIRLWDI-ECGACLRVLEGHEELVRCIRFD 439
Query: 218 SQKARGISGSAGKALAVWSLDWQQALQVR 246
++ R +SG+ + VW D Q AL R
Sbjct: 440 NK--RIVSGAYDGKIKVW--DLQAALDPR 464
Score = 34.7 bits (78), Expect = 0.12
Identities = 57/292 (19%), Positives = 114/292 (39%), Gaps = 37/292 (12%)
Query: 40 LFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKLCLWDLAE 99
+ SG + + IW + + L GH G V LQ R +++ D + +WD+
Sbjct: 240 IISGLRDNSIKIWDKTSLECLKVLTGHTGS-VLCLQY--DERVIVTGSSDSTVRVWDVNT 296
Query: 100 GRSAVVDSVCLESVGFCRSSILAGGQPRWTLAVPGRGSDEVQILEMPSKTSVCALKPKAD 159
G V++++ + G L V + + +M S T + +
Sbjct: 297 GE--VLNTLIHHNEAVLHLRFSNG------LMVTCSKDRSIAVWDMASATDITLRRVLVG 348
Query: 160 AKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQ 219
+ + + D + ++ A D ++ +W S + + H+ + L + +
Sbjct: 349 HRAAVNV------VDFDDKYIVSAS-GDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDR 401
Query: 220 KARGISGSAGKALAVWSLDWQQALQV-RGTHELTNPGIAEVTIRPDRKILATAGWDHRIR 278
+SGS+ + +W ++ L+V G EL IR D K + + +D +I+
Sbjct: 402 LV--VSGSSDNTIRLWDIECGACLRVLEGHEELVR------CIRFDNKRIVSGAYDGKIK 453
Query: 279 VFHWR-TMQP--------LAVLAFHSAAVQCVAFTADGLLAAGSKDQRISLW 321
V+ + + P L L HS V + F ++++ S D I +W
Sbjct: 454 VWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISS-SHDDTILIW 504
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 56.6 bits (135), Expect = 3e-08
Identities = 64/334 (19%), Positives = 117/334 (35%), Gaps = 46/334 (13%)
Query: 24 HALHFCEGAQAQGRPLLFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQTLPQGRQL 83
H L A + +GS +W + + TL+GH P G ++
Sbjct: 91 HILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKI 150
Query: 84 LSQGRDLKLCLWDLAEGRSAVVDSVCLESV-GFCRSSILAGGQPRWTLAVPGRGSDEVQI 142
+ D LW + G+ C + G + P+ TL G ++
Sbjct: 151 ATGSFDKTCKLWSVETGK-------CYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKL 203
Query: 143 LEMPSKTSVCALKPKADAKLGMPM--------------CLRLWQADCSSR---------- 178
++ + V L+ + + + + +W AD +
Sbjct: 204 WDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAE 263
Query: 179 ----------PLLLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQKARGISGSA 228
L+L G D + LWD + K + + H++ ++D FD + SA
Sbjct: 264 ISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASA 323
Query: 229 GKALAVWSLDWQQALQVRGTHELTNPGIAEVTIRPDRKILATAGWDHRIRVFHWRTMQPL 288
++S ++ + HE I++++ P L T D R++ +T Q L
Sbjct: 324 DGTARIFSAATRKCIAKLEGHE---GEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCL 380
Query: 289 AVLAFHSAAVQCVAFTADG-LLAAGSKDQRISLW 321
VL H+ + AF G ++ GSKD +W
Sbjct: 381 QVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 56.2 bits (134), Expect = 4e-08
Identities = 36/156 (23%), Positives = 72/156 (46%), Gaps = 9/156 (5%)
Query: 175 CSSRP---LLLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQKARGISGSAGKA 231
C+ P L+++G D +V +W+V K ++ H +PV + F+ + +SGS
Sbjct: 131 CNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGL 190
Query: 232 LAVWSLDWQQALQVRGTHELTNPGIAEVTIRPDRKILATAGWDHRIRVFHWRTMQPLAVL 291
+W Q L+ + NP ++ V P+ K + TA D+ ++++ + + L
Sbjct: 191 CRIWDAASGQCLKTLVDDD--NPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTY 248
Query: 292 AFHSAAVQCV----AFTADGLLAAGSKDQRISLWSL 323
H C+ + T + +GS+D + +W+L
Sbjct: 249 TGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 284
Score = 47.4 bits (111), Expect = 2e-05
Identities = 29/87 (33%), Positives = 43/87 (49%), Gaps = 7/87 (8%)
Query: 16 LRGTQSPVHALHF-CEGAQAQGRPLLFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWL 74
L PV A+HF C G+ L+ SGS GL IW + + + TL V+++
Sbjct: 163 LSAHSDPVSAVHFNCSGS------LIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFV 216
Query: 75 QTLPQGRQLLSQGRDLKLCLWDLAEGR 101
+ P G+ +L+ D L LWD + GR
Sbjct: 217 KFSPNGKYILTATLDNTLKLWDYSRGR 243
Score = 35.0 bits (79), Expect = 0.091
Identities = 15/31 (48%), Positives = 20/31 (64%)
Query: 36 GRPLLFSGSQSGLVHIWSLQTRRAVTTLDGH 66
G + SGS+ LV+IW+LQT+ V L GH
Sbjct: 266 GGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH 296
Score = 32.3 bits (72), Expect = 0.59
Identities = 50/269 (18%), Positives = 96/269 (35%), Gaps = 34/269 (12%)
Query: 24 HALHFCEGAQAQGRPLLFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQTLPQGRQL 83
H L + A + L S S + +W +++ + + TL GH V P +
Sbjct: 82 HNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNY-VFCCNFNPPSNLI 140
Query: 84 LSQGRDLKLCLWDLAEGR-----SAVVDSVCLESVGF-CRSSILAGGQPRWTLAVPGRGS 137
+S D + +W++ G+ SA D V +V F C S++ G + S
Sbjct: 141 ISGSFDETVKIWEVKTGKCLKTLSAHSDPV--SAVHFNCSGSLIVSGSYDGLCRIWDAAS 198
Query: 138 DE-VQILEMPSKTSVCALKPKADAKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVS 196
+ ++ L V +K + K +L D ++ LWD S
Sbjct: 199 GQCLKTLVDDDNPPVSFVKFSPNGK------------------YILTATLDNTLKLWDYS 240
Query: 197 EQKVCSRIACHEEPVMDLDFDSQKARG---ISGSAGKALAVWSLDWQQALQVRGTHELTN 253
+ H+ + + G +SGS + +W+L ++ +Q H
Sbjct: 241 RGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH---T 297
Query: 254 PGIAEVTIRPDRKILATAGWDHRIRVFHW 282
+ P ++A+A ++ + W
Sbjct: 298 DVVISAACHPTENLIASAALENDKTIKLW 326
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 55.8 bits (133), Expect = 5e-08
Identities = 38/150 (25%), Positives = 63/150 (42%), Gaps = 10/150 (6%)
Query: 178 RPLLLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQKARGISGSAGKALAVWSL 237
R LL+ EDG+V LW + H PV D F +SG + +W+
Sbjct: 555 RNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWAT 614
Query: 238 DWQQALQVRGTHELTNPGIAEVT---IRPDRKILATAGWDHRIRVFHWRTMQPLAVLAFH 294
D Q L++ H +A+V P+ +AT D +R++ + + H
Sbjct: 615 DHYQPLRIFAGH------LADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGH 668
Query: 295 SAAVQCVAFTADG-LLAAGSKDQRISLWSL 323
+ + F+ +G LA G+ D R+ LW +
Sbjct: 669 KGPIHSLTFSPNGRFLATGATDGRVLLWDI 698
Score = 43.1 bits (100), Expect = 3e-04
Identities = 50/221 (22%), Positives = 74/221 (33%), Gaps = 20/221 (9%)
Query: 15 VLRGTQSPVHALHFCEGAQAQGRPLLFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWL 74
+L G PV+ F + R L S S+ G V +WSLQT + GH V
Sbjct: 538 ILYGHSGPVYGASF-----SPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGH-NYPVWDT 591
Query: 75 QTLPQGRQLLSQGRDLKLCLWDLAEGRSAVVDSVCLESVGFCRSSILAGGQPRWTLAVPG 134
Q P G +S G D LW + + + L V R P G
Sbjct: 592 QFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRF------HPNSNYVATG 645
Query: 135 RGSDEVQILEMPSKTSVCALKPKADAKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWD 194
V++ ++ + V + + L G DG V+LWD
Sbjct: 646 SADRTVRLWDVLNGNCVRIFTGHKGPIHSLTF--------SPNGRFLATGATDGRVLLWD 697
Query: 195 VSEQKVCSRIACHEEPVMDLDFDSQKARGISGSAGKALAVW 235
+ + + H + V L F SGS + +W
Sbjct: 698 IGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 55.1 bits (131), Expect = 9e-08
Identities = 35/143 (24%), Positives = 62/143 (43%), Gaps = 1/143 (0%)
Query: 182 LAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQKARGISGSAGKALAVWSLDWQQ 241
L+G DG++ LWD++ R H + V+ + F S + +SGS K + +W+
Sbjct: 79 LSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVC 138
Query: 242 ALQVRGTHELTNPGIAEVTIRPDRKILATAGWDHRIRVFHWRTMQPLAVLAFHSAAVQCV 301
V+ + I+ + GWD ++V++ + H+ + V
Sbjct: 139 KYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTV 198
Query: 302 AFTADG-LLAAGSKDQRISLWSL 323
+ DG L A+G KD + LW L
Sbjct: 199 TVSPDGSLCASGGKDGQAMLWDL 221
Score = 51.2 bits (121), Expect = 1e-06
Identities = 46/170 (27%), Positives = 70/170 (41%), Gaps = 30/170 (17%)
Query: 38 PLLFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKLCLWDL 97
P++ S LV +W+L + T GH G T + P G S G+D + LWDL
Sbjct: 163 PIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNT-VTVSPDGSLCASGGKDGQAMLWDL 221
Query: 98 AEGR-------SAVVDSVCLESVGFCRSSILAGGQPRWTLAVPGRGSDEVQILEMPSKTS 150
EG+ +++++C + W A G ++I ++ K
Sbjct: 222 NEGKHLYTLDGGDIINALCFSPNRY------------WLCAATG---PSIKIWDLEGKII 266
Query: 151 VCALKPK---ADAKLGMPMCLRL-WQADCSSRPLLLAGYEDGSVVLWDVS 196
V LK + +K P C L W AD + L AGY D V +W V+
Sbjct: 267 VDELKQEVISTSSKAEPPQCTSLAWSADGQT---LFAGYTDNLVRVWQVT 313
Score = 38.5 bits (88), Expect = 0.008
Identities = 29/112 (25%), Positives = 48/112 (42%), Gaps = 23/112 (20%)
Query: 224 ISGSAGKALAVWSLDWQQALQVRGTHELTNPGI------------AEVTIRPDRKILATA 271
+S S K + +W L T + TN GI ++V I D + +
Sbjct: 32 LSASRDKTIIMWKL----------TRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSG 81
Query: 272 GWDHRIRVFHWRTMQPLAVLAFHSAAVQCVAFTADG-LLAAGSKDQRISLWS 322
WD +R++ T H+ V VAF++D + +GS+D+ I LW+
Sbjct: 82 SWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN 133
Score = 33.5 bits (75), Expect = 0.26
Identities = 41/196 (20%), Positives = 67/196 (34%), Gaps = 33/196 (16%)
Query: 12 PQFVLRGTQSPVHALHFCEGAQAQGRPLLFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCV 71
PQ LRG H+ + + SGS G + +W L T GH +
Sbjct: 55 PQRALRG-----HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVL 109
Query: 72 TWLQTLPQGRQLLSQGRDLKLCLWDLAEGRSAVVDSVCLESVGFCRSSILAGGQPRWTLA 131
+ + RQ++S RD + LW+ ++G C+ ++ W
Sbjct: 110 S-VAFSSDNRQIVSGSRDKTIKLWN---------------TLGVCKYTVQDESHSEWVSC 153
Query: 132 V---PGRGSDEVQILEMPSKTSV-----CALKPKADAKLGMPMCLRLWQADCSSRPLLLA 183
V P + + V C LK G + + L +
Sbjct: 154 VRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTV----SPDGSLCAS 209
Query: 184 GYEDGSVVLWDVSEQK 199
G +DG +LWD++E K
Sbjct: 210 GGKDGQAMLWDLNEGK 225
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 54.7 bits (130), Expect = 1e-07
Identities = 36/144 (25%), Positives = 71/144 (49%), Gaps = 5/144 (3%)
Query: 180 LLLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQKARGISGSAGKALAVWSLDW 239
+++ G D +V +WDV+ ++ + + H E V+ L F++ ++ S +++AVW +
Sbjct: 319 VIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMM--VTCSKDRSIAVWDMAS 376
Query: 240 QQALQVRGTHELTNPGIAEVTIRPDRKILATAGWDHRIRVFHWRTMQPLAVLAFHSAAVQ 299
+ +R L A + D K + +A D I+V++ T + + L H +
Sbjct: 377 PTDITLRRV--LVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIA 434
Query: 300 CVAFTADGLLAAGSKDQRISLWSL 323
C+ + D L+ +GS D I LW +
Sbjct: 435 CLQYR-DRLVVSGSSDNTIRLWDI 457
Score = 43.5 bits (101), Expect = 3e-04
Identities = 45/200 (22%), Positives = 82/200 (41%), Gaps = 22/200 (11%)
Query: 39 LLFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKLCLWDLA 98
++ +GS V +W + T + TL H C L +++ +D + +WD+A
Sbjct: 319 VIITGSSDSTVRVWDVNTGEMLNTLIHH---CEAVLHLRFNNGMMVTCSKDRSIAVWDMA 375
Query: 99 EGRSAVVDSVCLESVGFCRSSILAGGQPRWTLAVPGRGSDEVQILEMPSKTSVCALKPKA 158
+ V VG + + ++ ++ G + +V TS C
Sbjct: 376 SPTDITLRRVL---VGHRAAVNVVDFDDKYIVSASGDRTIKVW------NTSTCEFVRTL 426
Query: 159 DAKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRI-ACHEEPVMDLDFD 217
+ CL+ L+++G D ++ LWD+ E C R+ HEE V + FD
Sbjct: 427 NGHKRGIACLQYRDR------LVVSGSSDNTIRLWDI-ECGACLRVLEGHEELVRCIRFD 479
Query: 218 SQKARGISGSAGKALAVWSL 237
++ R +SG+ + VW L
Sbjct: 480 NK--RIVSGAYDGKIKVWDL 497
Score = 32.7 bits (73), Expect = 0.45
Identities = 58/292 (19%), Positives = 110/292 (37%), Gaps = 37/292 (12%)
Query: 40 LFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKLCLWDLAE 99
+ SG + + IW T L GH G V LQ R +++ D + +WD+
Sbjct: 280 IVSGLRDNTIKIWDKNTLECKRILTGHTGS-VLCLQY--DERVIITGSSDSTVRVWDVNT 336
Query: 100 GRSAVVDSVCLESVGFCRSSILAGGQPRWTLAVPGRGSDEVQILEMPSKTSVCALKPKAD 159
G E+V R + + V + + +M S T + +
Sbjct: 337 GEMLNTLIHHCEAVLHLRFNN--------GMMVTCSKDRSIAVWDMASPTDITLRRVLVG 388
Query: 160 AKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQ 219
+ + + D + ++ A D ++ +W+ S + + H+ + L + +
Sbjct: 389 HRAAVNV------VDFDDKYIVSAS-GDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDR 441
Query: 220 KARGISGSAGKALAVWSLDWQQALQV-RGTHELTNPGIAEVTIRPDRKILATAGWDHRIR 278
+SGS+ + +W ++ L+V G EL IR D K + + +D +I+
Sbjct: 442 LV--VSGSSDNTIRLWDIECGACLRVLEGHEELVR------CIRFDNKRIVSGAYDGKIK 493
Query: 279 VFHW-RTMQP--------LAVLAFHSAAVQCVAFTADGLLAAGSKDQRISLW 321
V+ + P L L HS V + F + + + S D I +W
Sbjct: 494 VWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFD-EFQIVSSSHDDTILIW 544
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 54.7 bits (130), Expect = 1e-07
Identities = 36/144 (25%), Positives = 71/144 (49%), Gaps = 5/144 (3%)
Query: 180 LLLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQKARGISGSAGKALAVWSLDW 239
+++ G D +V +WDV+ ++ + + H E V+ L F++ ++ S +++AVW +
Sbjct: 355 VIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMM--VTCSKDRSIAVWDMAS 412
Query: 240 QQALQVRGTHELTNPGIAEVTIRPDRKILATAGWDHRIRVFHWRTMQPLAVLAFHSAAVQ 299
+ +R L A + D K + +A D I+V++ T + + L H +
Sbjct: 413 PTDITLRRV--LVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIA 470
Query: 300 CVAFTADGLLAAGSKDQRISLWSL 323
C+ + D L+ +GS D I LW +
Sbjct: 471 CLQYR-DRLVVSGSSDNTIRLWDI 493
Score = 43.5 bits (101), Expect = 3e-04
Identities = 45/200 (22%), Positives = 82/200 (41%), Gaps = 22/200 (11%)
Query: 39 LLFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKLCLWDLA 98
++ +GS V +W + T + TL H C L +++ +D + +WD+A
Sbjct: 355 VIITGSSDSTVRVWDVNTGEMLNTLIHH---CEAVLHLRFNNGMMVTCSKDRSIAVWDMA 411
Query: 99 EGRSAVVDSVCLESVGFCRSSILAGGQPRWTLAVPGRGSDEVQILEMPSKTSVCALKPKA 158
+ V VG + + ++ ++ G + +V TS C
Sbjct: 412 SPTDITLRRVL---VGHRAAVNVVDFDDKYIVSASGDRTIKVW------NTSTCEFVRTL 462
Query: 159 DAKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRI-ACHEEPVMDLDFD 217
+ CL+ L+++G D ++ LWD+ E C R+ HEE V + FD
Sbjct: 463 NGHKRGIACLQYRDR------LVVSGSSDNTIRLWDI-ECGACLRVLEGHEELVRCIRFD 515
Query: 218 SQKARGISGSAGKALAVWSL 237
++ R +SG+ + VW L
Sbjct: 516 NK--RIVSGAYDGKIKVWDL 533
Score = 32.7 bits (73), Expect = 0.45
Identities = 58/292 (19%), Positives = 110/292 (37%), Gaps = 37/292 (12%)
Query: 40 LFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKLCLWDLAE 99
+ SG + + IW T L GH G V LQ R +++ D + +WD+
Sbjct: 316 IVSGLRDNTIKIWDKNTLECKRILTGHTGS-VLCLQY--DERVIITGSSDSTVRVWDVNT 372
Query: 100 GRSAVVDSVCLESVGFCRSSILAGGQPRWTLAVPGRGSDEVQILEMPSKTSVCALKPKAD 159
G E+V R + + V + + +M S T + +
Sbjct: 373 GEMLNTLIHHCEAVLHLRFNN--------GMMVTCSKDRSIAVWDMASPTDITLRRVLVG 424
Query: 160 AKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQ 219
+ + + D + ++ A D ++ +W+ S + + H+ + L + +
Sbjct: 425 HRAAVNV------VDFDDKYIVSAS-GDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDR 477
Query: 220 KARGISGSAGKALAVWSLDWQQALQV-RGTHELTNPGIAEVTIRPDRKILATAGWDHRIR 278
+SGS+ + +W ++ L+V G EL IR D K + + +D +I+
Sbjct: 478 LV--VSGSSDNTIRLWDIECGACLRVLEGHEELVR------CIRFDNKRIVSGAYDGKIK 529
Query: 279 VFHW-RTMQP--------LAVLAFHSAAVQCVAFTADGLLAAGSKDQRISLW 321
V+ + P L L HS V + F + + + S D I +W
Sbjct: 530 VWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFD-EFQIVSSSHDDTILIW 580
>gi|5729852 guanine nucleotide-binding protein, beta-5 subunit
isoform a [Homo sapiens]
Length = 353
Score = 54.3 bits (129), Expect = 1e-07
Identities = 67/281 (23%), Positives = 106/281 (37%), Gaps = 32/281 (11%)
Query: 54 LQTRRAVTTLDGHGGQ--CVTWLQTLPQGRQLLSQGRDLKLCLWD-LAEGRSAVVDSVCL 110
++TRR TL GHG + C+ W + R+++S +D K+ +WD + V C
Sbjct: 53 MKTRR---TLKGHGNKVLCMDWCK---DKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPC- 105
Query: 111 ESVGFCRSSILAGGQPRWTLAVPGRGSDE---VQILEMPSKTSVCALKPKADAKLGMPMC 167
+ ++A A+ G D V L ++ A K
Sbjct: 106 -------TWVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSA 158
Query: 168 LRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQKARG--IS 225
+D +L DG+ LWDV ++ H V+ LD + +S
Sbjct: 159 CSFTNSDMQ----ILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVS 214
Query: 226 GSAGKALAVWSLDWQQALQVRGTHELTNPGIAEVTIRPDRKILATAGWDHRIRVFHWRTM 285
G K VW + Q +Q THE I V P A+ D R++ R
Sbjct: 215 GGCDKKAMVWDMRSGQCVQAFETHE---SDINSVRYYPSGDAFASGSDDATCRLYDLRAD 271
Query: 286 QPLAVLAFHSA--AVQCVAFTADG-LLAAGSKDQRISLWSL 323
+ +A+ + S V F+ G LL AG D I++W +
Sbjct: 272 REVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDV 312
Score = 45.4 bits (106), Expect = 7e-05
Identities = 49/204 (24%), Positives = 72/204 (35%), Gaps = 25/204 (12%)
Query: 40 LFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQTLPQ--GRQLLSQGRDLKLCLWDL 97
+ + S G +W +++ + + + GHG V L P G +S G D K +WD+
Sbjct: 168 ILTASGDGTCALWDVESGQLLQSFHGHGAD-VLCLDLAPSETGNTFVSGGCDKKAMVWDM 226
Query: 98 AEGRSAVVDSVCLESVGFCR-----SSILAGGQPRWTLAVPGRGSDEVQILEMPSKTSVC 152
G+ + R + +G R EV I SK S+
Sbjct: 227 RSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIY---SKESII 283
Query: 153 ALKPKADAKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACHEEPVM 212
D L S LL AGY D ++ +WDV + S + HE V
Sbjct: 284 FGASSVDFSL--------------SGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVS 329
Query: 213 DLDFDSQKARGISGSAGKALAVWS 236
L SGS L VW+
Sbjct: 330 TLRVSPDGTAFCSGSWDHTLRVWA 353
Score = 28.9 bits (63), Expect = 6.5
Identities = 17/57 (29%), Positives = 27/57 (47%), Gaps = 1/57 (1%)
Query: 39 LLFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKLCLW 95
LLF+G +++W + V+ L GH + V+ L+ P G S D L +W
Sbjct: 297 LLFAGYNDYTINVWDVLKGSRVSILFGHENR-VSTLRVSPDGTAFCSGSWDHTLRVW 352
>gi|20336270 guanine nucleotide-binding protein, beta-5 subunit
isoform b [Homo sapiens]
Length = 395
Score = 54.3 bits (129), Expect = 1e-07
Identities = 67/281 (23%), Positives = 106/281 (37%), Gaps = 32/281 (11%)
Query: 54 LQTRRAVTTLDGHGGQ--CVTWLQTLPQGRQLLSQGRDLKLCLWD-LAEGRSAVVDSVCL 110
++TRR TL GHG + C+ W + R+++S +D K+ +WD + V C
Sbjct: 95 MKTRR---TLKGHGNKVLCMDWCK---DKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPC- 147
Query: 111 ESVGFCRSSILAGGQPRWTLAVPGRGSDE---VQILEMPSKTSVCALKPKADAKLGMPMC 167
+ ++A A+ G D V L ++ A K
Sbjct: 148 -------TWVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSA 200
Query: 168 LRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQKARG--IS 225
+D +L DG+ LWDV ++ H V+ LD + +S
Sbjct: 201 CSFTNSDMQ----ILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVS 256
Query: 226 GSAGKALAVWSLDWQQALQVRGTHELTNPGIAEVTIRPDRKILATAGWDHRIRVFHWRTM 285
G K VW + Q +Q THE I V P A+ D R++ R
Sbjct: 257 GGCDKKAMVWDMRSGQCVQAFETHE---SDINSVRYYPSGDAFASGSDDATCRLYDLRAD 313
Query: 286 QPLAVLAFHSA--AVQCVAFTADG-LLAAGSKDQRISLWSL 323
+ +A+ + S V F+ G LL AG D I++W +
Sbjct: 314 REVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDV 354
Score = 45.4 bits (106), Expect = 7e-05
Identities = 49/204 (24%), Positives = 72/204 (35%), Gaps = 25/204 (12%)
Query: 40 LFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQTLPQ--GRQLLSQGRDLKLCLWDL 97
+ + S G +W +++ + + + GHG V L P G +S G D K +WD+
Sbjct: 210 ILTASGDGTCALWDVESGQLLQSFHGHGAD-VLCLDLAPSETGNTFVSGGCDKKAMVWDM 268
Query: 98 AEGRSAVVDSVCLESVGFCR-----SSILAGGQPRWTLAVPGRGSDEVQILEMPSKTSVC 152
G+ + R + +G R EV I SK S+
Sbjct: 269 RSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIY---SKESII 325
Query: 153 ALKPKADAKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACHEEPVM 212
D L S LL AGY D ++ +WDV + S + HE V
Sbjct: 326 FGASSVDFSL--------------SGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVS 371
Query: 213 DLDFDSQKARGISGSAGKALAVWS 236
L SGS L VW+
Sbjct: 372 TLRVSPDGTAFCSGSWDHTLRVWA 395
Score = 28.9 bits (63), Expect = 6.5
Identities = 17/57 (29%), Positives = 27/57 (47%), Gaps = 1/57 (1%)
Query: 39 LLFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKLCLW 95
LLF+G +++W + V+ L GH + V+ L+ P G S D L +W
Sbjct: 339 LLFAGYNDYTINVWDVLKGSRVSILFGHENR-VSTLRVSPDGTAFCSGSWDHTLRVW 394
>gi|8923881 WD SOCS-box protein 2 [Homo sapiens]
Length = 404
Score = 54.3 bits (129), Expect = 1e-07
Identities = 61/294 (20%), Positives = 103/294 (35%), Gaps = 67/294 (22%)
Query: 39 LLFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQTLPQGRQLL-SQGRDLKLCLWDL 97
+L +G G + IW +QT + L GH V L P G +L S RD L +WDL
Sbjct: 125 VLATGLNDGQIKIWEVQTGLLLLNLSGH-QDVVRDLSFTPSGSLILVSASRDKTLRIWDL 183
Query: 98 AEGRSAVVDSVCLESVGFCRSSILAGGQPRWTLAVPGRGSDEVQILEMPSKTSVCALKPK 157
+ + + G +W C++ P
Sbjct: 184 NKHGKQIQ---------------VLSGHLQWVYC--------------------CSISP- 207
Query: 158 ADAKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFD 217
DCS +L + + SV LW + + ++ H+ V+ DF
Sbjct: 208 ----------------DCS---MLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFS 248
Query: 218 SQKARGISGSAGKALAVW---------SLDWQQALQVRGTHELTNPGIAEVTIRPDRKIL 268
A ++ S + +W SL Q ++ + V P+ L
Sbjct: 249 PDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEGLYL 308
Query: 269 ATAGWDHRIRVFHWRTMQPLAVLAFHSAAVQCVAFTADGLLAAGSKDQRISLWS 322
AT D +R++ P+A A + + C F G++A G++D + W+
Sbjct: 309 ATVADDRLLRIWALELKTPIA-FAPMTNGLCCTFFPHGGVIATGTRDGHVQFWT 361
Score = 51.6 bits (122), Expect = 9e-07
Identities = 49/199 (24%), Positives = 82/199 (41%), Gaps = 16/199 (8%)
Query: 134 GRGSDEVQILEMPSKTSVCALKPKADAKLGMPMCLRLWQADCSSRP-----LLLAGYEDG 188
GRGS + + L+ A P P +LW P +L G DG
Sbjct: 79 GRGSPKEKTLDCGQIVWGLAFSPWPS-----PPSRKLWARHHPQVPDVSCLVLATGLNDG 133
Query: 189 SVVLWDVSEQKVCSRIACHEEPVMDLDF-DSQKARGISGSAGKALAVWSLDWQ-QALQVR 246
+ +W+V + ++ H++ V DL F S +S S K L +W L+ + +QV
Sbjct: 134 QIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQIQVL 193
Query: 247 GTHELTNPGIAEVTIRPDRKILATAGWDHRIRVFHWRTMQPLAVLAFHSAAVQCVAFTAD 306
H + +I PD +L +A + + ++ R+ + L H ++V F+ D
Sbjct: 194 SGH---LQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPD 250
Query: 307 -GLLAAGSKDQRISLWSLY 324
LL S D + +W Y
Sbjct: 251 SALLVTASYDTNVIMWDPY 269
>gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [Homo
sapiens]
Length = 340
Score = 53.9 bits (128), Expect = 2e-07
Identities = 75/319 (23%), Positives = 122/319 (38%), Gaps = 41/319 (12%)
Query: 16 LRGTQSPVHALHFCEGAQAQGRPLLFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQ 75
LRG + ++A+H+ ++ LL S SQ G + +W T V + +W+
Sbjct: 51 LRGHLAKIYAMHWATDSK-----LLVSASQDGKLIVWDSYTTNKVHAIPLRS----SWVM 101
Query: 76 TL---PQGRQLLSQGRDLKLCLWDLAEGRSAVVDSVCLES-VGFCRSSILAGGQPRWTLA 131
T P G + G D +++L V S L + G+
Sbjct: 102 TCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCC------------ 149
Query: 132 VPGRGSDEVQILEMPSKTSVCALKPKADAKLGMPMCLRLWQA-DCSSRP------LLLAG 184
R D+ I+ T+ CAL D + G + + DC S L ++G
Sbjct: 150 ---RFLDDNNIVTSSGDTT-CALW---DIETGQQKTVFVGHTGDCMSLAVSPDFNLFISG 202
Query: 185 YEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQKARGISGSAGKALAVWSLDWQQALQ 244
D S LWDV E HE + + F +GS + ++ L Q L
Sbjct: 203 ACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQEL- 261
Query: 245 VRGTHELTNPGIAEVTIRPDRKILATAGWDHRIRVFHWRTMQPLAVLAFHSAAVQCVAFT 304
+ +HE GI V ++L D V+ + + +L+ H V C+ T
Sbjct: 262 ICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVT 321
Query: 305 ADGL-LAAGSKDQRISLWS 322
ADG+ +A GS D + +W+
Sbjct: 322 ADGMAVATGSWDSFLKIWN 340
>gi|50980309 UTP15, U3 small nucleolar ribonucleoprotein, homolog
[Homo sapiens]
Length = 518
Score = 53.5 bits (127), Expect = 2e-07
Identities = 36/145 (24%), Positives = 69/145 (47%), Gaps = 5/145 (3%)
Query: 180 LLLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQKARGISGSAGKALAVWSL-D 238
LL+AG EDG V L+D+S + + H + V +DF + K +SG+ + +W + +
Sbjct: 94 LLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPN 153
Query: 239 WQQALQVRGTHELTNPGIAEVTIRPDRKILATAGWDHRIRVFHWRTMQPLAVLAFHSAAV 298
++ L + + G A + PD + T +DH +++F RT + + + H V
Sbjct: 154 SKEILTFKEHSDYVRCGCAS-KLNPD--LFITGSYDHTVKMFDARTSESVLSVE-HGQPV 209
Query: 299 QCVAFTADGLLAAGSKDQRISLWSL 323
+ V G L + + + +W +
Sbjct: 210 ESVLLFPSGGLLVSAGGRYVKVWDM 234
Score = 30.0 bits (66), Expect = 2.9
Identities = 16/53 (30%), Positives = 26/53 (49%), Gaps = 1/53 (1%)
Query: 276 RIRVFHWRTMQPLAVLAFHSAAVQCVAFTADG-LLAAGSKDQRISLWSLYPRA 327
RI ++ + +P+ + C F DG LL AGS+D + L+ + RA
Sbjct: 61 RIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRA 113
>gi|55769546 PAK1 interacting protein 1 [Homo sapiens]
Length = 392
Score = 53.5 bits (127), Expect = 2e-07
Identities = 28/73 (38%), Positives = 41/73 (56%), Gaps = 1/73 (1%)
Query: 36 GRPLLFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKLCLW 95
G L SG++ GL+ IW + + ++ H GQ VT+L P G+ LS G D L W
Sbjct: 92 GNRHLISGAEDGLICIWDAKKWECLKSIKAHKGQ-VTFLSIHPSGKLALSVGTDKTLRTW 150
Query: 96 DLAEGRSAVVDSV 108
+L EGRSA + ++
Sbjct: 151 NLVEGRSAFIKNI 163
Score = 35.8 bits (81), Expect = 0.053
Identities = 37/187 (19%), Positives = 74/187 (39%), Gaps = 15/187 (8%)
Query: 132 VPGRGSDEVQILEMPSKTSVCALKPKADAKLGMPMCLRLWQADCSSRPLLLAGYEDGSVV 191
V G + + I +M K AL + G CL+ + L++G EDG +
Sbjct: 56 VTGSKDETIHIYDMKKKIEHGALVHHS----GTITCLKFY-----GNRHLISGAEDGLIC 106
Query: 192 LWDVSEQKVCSRIACHEEPVMDLDFDSQKARGISGSAGKALAVWSLDWQQALQVRGTHEL 251
+WD + + I H+ V L +S K L W+L ++ ++ +
Sbjct: 107 IWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNIKQ- 165
Query: 252 TNPGIAEVTIRPDRKILATAGWDHRIRVFHWRTMQPLAVLAFHSAAVQCVAFTADGLLAA 311
N I E + R ++ ++ ++I ++ T + + + V F ++ +LA
Sbjct: 166 -NAHIVEWSPRGEQYVVII---QNKIDIYQLDTASISGTIT-NEKRISSVKFLSESVLAV 220
Query: 312 GSKDQRI 318
++ I
Sbjct: 221 AGDEEVI 227
Score = 32.3 bits (72), Expect = 0.59
Identities = 16/74 (21%), Positives = 32/74 (43%), Gaps = 2/74 (2%)
Query: 248 THELTNPGIAEVTIRPDRKILATAGWDHRIRVFHWRTMQPLAVLAFHSAAVQCVAFTADG 307
TH ++ V + + + + T D I ++ + L HS + C+ F +
Sbjct: 37 THHAHTASLSAVAV--NSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNR 94
Query: 308 LLAAGSKDQRISLW 321
L +G++D I +W
Sbjct: 95 HLISGAEDGLICIW 108
>gi|38569484 kinesin family member 21A [Homo sapiens]
Length = 1661
Score = 53.1 bits (126), Expect = 3e-07
Identities = 69/326 (21%), Positives = 127/326 (38%), Gaps = 36/326 (11%)
Query: 22 PVHALHFCEGAQA------QGRPLLFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQ 75
P+ +H EG LLF+GS+ +W+L T + + +L GH V+
Sbjct: 1323 PLQCIHIAEGHTKAVLCVDSTDDLLFTGSKDRTCKVWNLVTGQEIMSLGGHPNNVVS--V 1380
Query: 76 TLPQGRQLLSQGRDLKLCLWDLAEGRSAVVDSVCLESVGFCRSSILAGGQPRWTLAVPGR 135
L+ + +WD+ + + L S G T+A+P
Sbjct: 1381 KYCNYTSLVFTVSTSYIKVWDIRDSAKCI---RTLTSSGQVTLGDACSASTSRTVAIPSG 1437
Query: 136 GSDEVQILEMPSKTSVCALKPKA----DAK-----------LGMPMCLRLWQADCSSRPL 180
+ QI P+ T + A A D K LG MCL + Q S + L
Sbjct: 1438 ENQINQIALNPTGTFLYAASGNAVRMWDLKRFQSTGKLTGHLGPVMCLTVDQIS-SGQDL 1496
Query: 181 LLAGYEDGSVVLWDVSEQKVCSRIACHE-EPVMDLDFDSQKARG---ISGSAGKALAVWS 236
++ G +D + ++DV+E + + H EP ++ +G SGS + W
Sbjct: 1497 IITGSKDHYIKMFDVTEGALGTVSPTHNFEPPHYDGIEALTIQGDNLFSGSRDNGIKKWD 1556
Query: 237 LDWQQAL-QVRGTHELTNPGIAEVTIRPDRKILATAGWDHRIRVFHWRTMQPLAVLAFHS 295
L + L QV H+ + + + PD +L + ++V++ T P+ + H
Sbjct: 1557 LTQKDLLQQVPNAHK---DWVCALGVVPDHPVLLSGCRGGILKVWNMDTFMPVGEMKGHD 1613
Query: 296 AAVQCVAFTADGLLAAGSKDQRISLW 321
+ + + + + A + D+ + +W
Sbjct: 1614 SPINAICVNSTHIFTA-ADDRTVRIW 1638
Score = 30.0 bits (66), Expect = 2.9
Identities = 16/39 (41%), Positives = 23/39 (58%), Gaps = 1/39 (2%)
Query: 285 MQPLAVLAFHSAAVQCVAFTADGLLAAGSKDQRISLWSL 323
+Q + + H+ AV CV T D LL GSKD+ +W+L
Sbjct: 1324 LQCIHIAEGHTKAVLCVDST-DDLLFTGSKDRTCKVWNL 1361
>gi|62234438 Notchless gene homolog isoform b [Homo sapiens]
Length = 193
Score = 53.1 bits (126), Expect = 3e-07
Identities = 37/105 (35%), Positives = 58/105 (55%), Gaps = 7/105 (6%)
Query: 222 RGISGSAGKALAVWSL--DWQQALQVRGTHELTNPGIAEVTIRPDRKILATAGWDHRIRV 279
R +SGS L +WS D + ++ G L N +V PD +I+A+A +D I++
Sbjct: 51 RLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALIN----QVLFSPDSRIVASASFDKSIKL 106
Query: 280 FHWRTMQPLAVLAFHSAAVQCVAFTADG-LLAAGSKDQRISLWSL 323
+ RT + LA L H AAV +A++AD LL +GS D + +W +
Sbjct: 107 WDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDV 151
Score = 41.6 bits (96), Expect = 0.001
Identities = 21/65 (32%), Positives = 32/65 (49%), Gaps = 3/65 (4%)
Query: 171 WQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQKARGISGSAGK 230
W AD LL++G D ++ +WDV QK+ + H + V +D+ R SG K
Sbjct: 130 WSADSR---LLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDK 186
Query: 231 ALAVW 235
L +W
Sbjct: 187 CLRIW 191
Score = 35.0 bits (79), Expect = 0.091
Identities = 18/59 (30%), Positives = 30/59 (50%), Gaps = 5/59 (8%)
Query: 39 LLFSGSQSGLVHIWSLQTRRAVTTLDGHGGQ--CVTWLQTLPQGRQLLSQGRDLKLCLW 95
LL SGS + +W ++ ++ L GH + V W P G+++ S G+D L +W
Sbjct: 136 LLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDW---SPDGQRVASGGKDKCLRIW 191
Score = 33.9 bits (76), Expect = 0.20
Identities = 26/98 (26%), Positives = 45/98 (45%), Gaps = 7/98 (7%)
Query: 187 DGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQKARGISGSAGKALAVWSLDWQQ-ALQV 245
D S+ LWD K + + H V + + + +SGS+ L VW + Q+ A+ +
Sbjct: 101 DKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDL 160
Query: 246 RGTHELTNPGIAEVTIRPDRKILATAGWDHRIRVFHWR 283
G + + V PD + +A+ G D +R+ WR
Sbjct: 161 PGHAD----EVYAVDWSPDGQRVASGGKDKCLRI--WR 192
>gi|7706657 cell division cycle 40 homolog [Homo sapiens]
Length = 579
Score = 52.8 bits (125), Expect = 4e-07
Identities = 54/242 (22%), Positives = 96/242 (39%), Gaps = 44/242 (18%)
Query: 49 VHIWSLQTRRAVTTLDGHGGQCVTWLQTLP-QGRQLLSQGRDLKLCLWDLAE-------- 99
+H+WS T+ V+ ++ P G LLS D K+ LW++
Sbjct: 281 IHVWSGHTKG------------VSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTF 328
Query: 100 -GRSAVVDSVCLESVGFCRSSILAGGQPRWTLAVPGRGSDEVQILEMPSKTSVCALKPKA 158
G S V +C + G + L+ R+ + ++T C +
Sbjct: 329 IGHSKAVRDICFNTAG---TQFLSAAYDRY-------------LKLWDTETGQCISR--- 369
Query: 159 DAKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDS 218
+P C++ + D + L +AG D +V WD+ ++ H V + F
Sbjct: 370 FTNRKVPYCVK-FNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVD 428
Query: 219 QKARGISGSAGKALAVWSLDWQQALQVRGTHELTNPGIAEVTIRPDRKILATAGWDHRIR 278
+ R +S S K+L VW +W + + E + + VT+ P+ K LA D++I
Sbjct: 429 ENRRFVSTSDDKSLRVW--EWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQIL 486
Query: 279 VF 280
+F
Sbjct: 487 IF 488
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 50.8 bits (120), Expect = 2e-06
Identities = 60/287 (20%), Positives = 113/287 (39%), Gaps = 32/287 (11%)
Query: 40 LFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKLCLWDLAE 99
+ SGS + +WS T + + TL GH G W + + ++S D L +W+
Sbjct: 276 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGG--VWSSQM-RDNIIISGSTDRTLKVWNAET 332
Query: 100 GRSAVVDSVCLESVGFCRSSILAGGQPRWTLAVPGRGSDEVQILEMPSKTSVCALKPKAD 159
G C+ ++ + +S + V G +++ ++ + + L
Sbjct: 333 GE-------CIHTL-YGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVL----- 379
Query: 160 AKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQ 219
+G +R Q D +++G D V +WD + + H V L FD
Sbjct: 380 --MGHVAAVRCVQYDGRR---VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDG- 433
Query: 220 KARGISGSAGKALAVWSLDWQQALQVRGTHELTNPGIAEVTIRPDRKILATAGWDHRIRV 279
+SGS ++ VW ++ + H+ G + IL + D +++
Sbjct: 434 -IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG-----MELKDNILVSGNADSTVKI 487
Query: 280 FHWRTMQPLAVLA---FHSAAVQCVAFTADGLLAAGSKDQRISLWSL 323
+ +T Q L L H +AV C+ F + ++ + S D + LW L
Sbjct: 488 WDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITS-SDDGTVKLWDL 533
Score = 40.0 bits (92), Expect = 0.003
Identities = 37/148 (25%), Positives = 63/148 (42%), Gaps = 12/148 (8%)
Query: 175 CSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQKARGISGSAGKALAV 234
C +R +++G +D ++ +W K + H V ISGS + L V
Sbjct: 272 CGNR--IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNII--ISGSTDRTLKV 327
Query: 235 WSLDWQQALQVRGTHELTNPGIAEVTIRPDRKILATAGWDHRIRVFHWRTMQPLAVLAFH 294
W+ + + + H T + K + + D +RV+ T Q L VL H
Sbjct: 328 WNAETGECIHTLYGHTSTVR-----CMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGH 382
Query: 295 SAAVQCVAFTADG-LLAAGSKDQRISLW 321
AAV+CV + DG + +G+ D + +W
Sbjct: 383 VAAVRCVQY--DGRRVVSGAYDFMVKVW 408
Score = 38.5 bits (88), Expect = 0.008
Identities = 40/164 (24%), Positives = 73/164 (44%), Gaps = 21/164 (12%)
Query: 33 QAQGRPLLFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKL 92
Q GR ++ SG+ +V +W +T + TL GH + V LQ G ++S D +
Sbjct: 390 QYDGRRVV-SGAYDFMVKVWDPETETCLHTLQGHTNR-VYSLQF--DGIHVVSGSLDTSI 445
Query: 93 CLWDLAEGRSAVVDSVCLESVGFCRSSILAGGQPRWTLAVPGRGSDEVQILEMPSKTSVC 152
+WD+ G C+ ++ S+ +G + + + V G V+I ++ KT C
Sbjct: 446 RVWDVETGN-------CIHTL-TGHQSLTSGMELKDNILVSGNADSTVKIWDI--KTGQC 495
Query: 153 ALKPKADAK-LGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDV 195
+ K CL+ ++ ++ +DG+V LWD+
Sbjct: 496 LQTLQGPNKHQSAVTCLQF------NKNFVITSSDDGTVKLWDL 533
Score = 36.2 bits (82), Expect = 0.041
Identities = 42/208 (20%), Positives = 84/208 (40%), Gaps = 27/208 (12%)
Query: 39 LLFSGSQSGLVHIWSLQTRRAVTTLDGHGG--QCVTWLQTLPQGRQLLSQGRDLKLCLWD 96
++ SGS + +W+ +T + TL GH +C+ + ++++S RD L +WD
Sbjct: 315 IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE-----KRVVSGSRDATLRVWD 369
Query: 97 LAEGRSAVVDSVCLESVGFCRSSILAGGQPRWTLAVPGRGSDEVQILEMPSKTSVCALKP 156
+ G+ V + V R G + V G V++ + ++T + L+
Sbjct: 370 IETGQCL---HVLMGHVAAVRCVQYDGRR-----VVSGAYDFMVKVWDPETETCLHTLQG 421
Query: 157 KADAKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDF 216
+ + Q D +++G D S+ +WDV + H+ ++
Sbjct: 422 HTNRVYSL-------QFDGIH---VVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL 471
Query: 217 DSQKARGISGSAGKALAVWSLDWQQALQ 244
+SG+A + +W + Q LQ
Sbjct: 472 KDNIL--VSGNADSTVKIWDIKTGQCLQ 497
Score = 31.6 bits (70), Expect = 1.0
Identities = 24/91 (26%), Positives = 42/91 (46%), Gaps = 20/91 (21%)
Query: 16 LRGTQSPVHALHFCEGAQAQGRPLLFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQ 75
L+G + V++L F +G + SGS + +W ++T + TL GH Q
Sbjct: 419 LQGHTNRVYSLQF-DGIH------VVSGSLDTSIRVWDVETGNCIHTLTGH--------Q 463
Query: 76 TLPQGRQ-----LLSQGRDLKLCLWDLAEGR 101
+L G + L+S D + +WD+ G+
Sbjct: 464 SLTSGMELKDNILVSGNADSTVKIWDIKTGQ 494
Score = 30.4 bits (67), Expect = 2.2
Identities = 25/78 (32%), Positives = 37/78 (47%), Gaps = 5/78 (6%)
Query: 39 LLFSGSQSGLVHIWSLQTRRAVTTLDGHG--GQCVTWLQTLPQGRQLLSQGRDLKLCLWD 96
+L SG+ V IW ++T + + TL G VT LQ +++ D + LWD
Sbjct: 475 ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQF--NKNFVITSSDDGTVKLWD 532
Query: 97 LAEGRSAVVDSVCLESVG 114
L G + + V LES G
Sbjct: 533 LKTG-EFIRNLVTLESGG 549
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 50.8 bits (120), Expect = 2e-06
Identities = 60/287 (20%), Positives = 113/287 (39%), Gaps = 32/287 (11%)
Query: 40 LFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKLCLWDLAE 99
+ SGS + +WS T + + TL GH G W + + ++S D L +W+
Sbjct: 394 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGG--VWSSQM-RDNIIISGSTDRTLKVWNAET 450
Query: 100 GRSAVVDSVCLESVGFCRSSILAGGQPRWTLAVPGRGSDEVQILEMPSKTSVCALKPKAD 159
G C+ ++ + +S + V G +++ ++ + + L
Sbjct: 451 GE-------CIHTL-YGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVL----- 497
Query: 160 AKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQ 219
+G +R Q D +++G D V +WD + + H V L FD
Sbjct: 498 --MGHVAAVRCVQYDGRR---VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDG- 551
Query: 220 KARGISGSAGKALAVWSLDWQQALQVRGTHELTNPGIAEVTIRPDRKILATAGWDHRIRV 279
+SGS ++ VW ++ + H+ G + IL + D +++
Sbjct: 552 -IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG-----MELKDNILVSGNADSTVKI 605
Query: 280 FHWRTMQPLAVLA---FHSAAVQCVAFTADGLLAAGSKDQRISLWSL 323
+ +T Q L L H +AV C+ F + ++ + S D + LW L
Sbjct: 606 WDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITS-SDDGTVKLWDL 651
Score = 40.0 bits (92), Expect = 0.003
Identities = 37/148 (25%), Positives = 63/148 (42%), Gaps = 12/148 (8%)
Query: 175 CSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQKARGISGSAGKALAV 234
C +R +++G +D ++ +W K + H V ISGS + L V
Sbjct: 390 CGNR--IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNII--ISGSTDRTLKV 445
Query: 235 WSLDWQQALQVRGTHELTNPGIAEVTIRPDRKILATAGWDHRIRVFHWRTMQPLAVLAFH 294
W+ + + + H T + K + + D +RV+ T Q L VL H
Sbjct: 446 WNAETGECIHTLYGHTSTVR-----CMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGH 500
Query: 295 SAAVQCVAFTADG-LLAAGSKDQRISLW 321
AAV+CV + DG + +G+ D + +W
Sbjct: 501 VAAVRCVQY--DGRRVVSGAYDFMVKVW 526
Score = 38.5 bits (88), Expect = 0.008
Identities = 40/164 (24%), Positives = 73/164 (44%), Gaps = 21/164 (12%)
Query: 33 QAQGRPLLFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKL 92
Q GR ++ SG+ +V +W +T + TL GH + V LQ G ++S D +
Sbjct: 508 QYDGRRVV-SGAYDFMVKVWDPETETCLHTLQGHTNR-VYSLQF--DGIHVVSGSLDTSI 563
Query: 93 CLWDLAEGRSAVVDSVCLESVGFCRSSILAGGQPRWTLAVPGRGSDEVQILEMPSKTSVC 152
+WD+ G C+ ++ S+ +G + + + V G V+I ++ KT C
Sbjct: 564 RVWDVETGN-------CIHTL-TGHQSLTSGMELKDNILVSGNADSTVKIWDI--KTGQC 613
Query: 153 ALKPKADAK-LGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDV 195
+ K CL+ ++ ++ +DG+V LWD+
Sbjct: 614 LQTLQGPNKHQSAVTCLQF------NKNFVITSSDDGTVKLWDL 651
Score = 36.2 bits (82), Expect = 0.041
Identities = 42/208 (20%), Positives = 84/208 (40%), Gaps = 27/208 (12%)
Query: 39 LLFSGSQSGLVHIWSLQTRRAVTTLDGHGG--QCVTWLQTLPQGRQLLSQGRDLKLCLWD 96
++ SGS + +W+ +T + TL GH +C+ + ++++S RD L +WD
Sbjct: 433 IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE-----KRVVSGSRDATLRVWD 487
Query: 97 LAEGRSAVVDSVCLESVGFCRSSILAGGQPRWTLAVPGRGSDEVQILEMPSKTSVCALKP 156
+ G+ V + V R G + V G V++ + ++T + L+
Sbjct: 488 IETGQCL---HVLMGHVAAVRCVQYDGRR-----VVSGAYDFMVKVWDPETETCLHTLQG 539
Query: 157 KADAKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDF 216
+ + Q D +++G D S+ +WDV + H+ ++
Sbjct: 540 HTNRVYSL-------QFDGIH---VVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL 589
Query: 217 DSQKARGISGSAGKALAVWSLDWQQALQ 244
+SG+A + +W + Q LQ
Sbjct: 590 KDNIL--VSGNADSTVKIWDIKTGQCLQ 615
Score = 31.6 bits (70), Expect = 1.0
Identities = 24/91 (26%), Positives = 42/91 (46%), Gaps = 20/91 (21%)
Query: 16 LRGTQSPVHALHFCEGAQAQGRPLLFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQ 75
L+G + V++L F +G + SGS + +W ++T + TL GH Q
Sbjct: 537 LQGHTNRVYSLQF-DGIH------VVSGSLDTSIRVWDVETGNCIHTLTGH--------Q 581
Query: 76 TLPQGRQ-----LLSQGRDLKLCLWDLAEGR 101
+L G + L+S D + +WD+ G+
Sbjct: 582 SLTSGMELKDNILVSGNADSTVKIWDIKTGQ 612
Score = 30.4 bits (67), Expect = 2.2
Identities = 25/78 (32%), Positives = 37/78 (47%), Gaps = 5/78 (6%)
Query: 39 LLFSGSQSGLVHIWSLQTRRAVTTLDGHG--GQCVTWLQTLPQGRQLLSQGRDLKLCLWD 96
+L SG+ V IW ++T + + TL G VT LQ +++ D + LWD
Sbjct: 593 ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQF--NKNFVITSSDDGTVKLWD 650
Query: 97 LAEGRSAVVDSVCLESVG 114
L G + + V LES G
Sbjct: 651 LKTG-EFIRNLVTLESGG 667
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 50.8 bits (120), Expect = 2e-06
Identities = 60/287 (20%), Positives = 113/287 (39%), Gaps = 32/287 (11%)
Query: 40 LFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKLCLWDLAE 99
+ SGS + +WS T + + TL GH G W + + ++S D L +W+
Sbjct: 314 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGG--VWSSQM-RDNIIISGSTDRTLKVWNAET 370
Query: 100 GRSAVVDSVCLESVGFCRSSILAGGQPRWTLAVPGRGSDEVQILEMPSKTSVCALKPKAD 159
G C+ ++ + +S + V G +++ ++ + + L
Sbjct: 371 GE-------CIHTL-YGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVL----- 417
Query: 160 AKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQ 219
+G +R Q D +++G D V +WD + + H V L FD
Sbjct: 418 --MGHVAAVRCVQYDGRR---VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDG- 471
Query: 220 KARGISGSAGKALAVWSLDWQQALQVRGTHELTNPGIAEVTIRPDRKILATAGWDHRIRV 279
+SGS ++ VW ++ + H+ G + IL + D +++
Sbjct: 472 -IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG-----MELKDNILVSGNADSTVKI 525
Query: 280 FHWRTMQPLAVLA---FHSAAVQCVAFTADGLLAAGSKDQRISLWSL 323
+ +T Q L L H +AV C+ F + ++ + S D + LW L
Sbjct: 526 WDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITS-SDDGTVKLWDL 571
Score = 40.0 bits (92), Expect = 0.003
Identities = 37/148 (25%), Positives = 63/148 (42%), Gaps = 12/148 (8%)
Query: 175 CSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDFDSQKARGISGSAGKALAV 234
C +R +++G +D ++ +W K + H V ISGS + L V
Sbjct: 310 CGNR--IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNII--ISGSTDRTLKV 365
Query: 235 WSLDWQQALQVRGTHELTNPGIAEVTIRPDRKILATAGWDHRIRVFHWRTMQPLAVLAFH 294
W+ + + + H T + K + + D +RV+ T Q L VL H
Sbjct: 366 WNAETGECIHTLYGHTSTVR-----CMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGH 420
Query: 295 SAAVQCVAFTADG-LLAAGSKDQRISLW 321
AAV+CV + DG + +G+ D + +W
Sbjct: 421 VAAVRCVQY--DGRRVVSGAYDFMVKVW 446
Score = 38.5 bits (88), Expect = 0.008
Identities = 40/164 (24%), Positives = 73/164 (44%), Gaps = 21/164 (12%)
Query: 33 QAQGRPLLFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQTLPQGRQLLSQGRDLKL 92
Q GR ++ SG+ +V +W +T + TL GH + V LQ G ++S D +
Sbjct: 428 QYDGRRVV-SGAYDFMVKVWDPETETCLHTLQGHTNR-VYSLQF--DGIHVVSGSLDTSI 483
Query: 93 CLWDLAEGRSAVVDSVCLESVGFCRSSILAGGQPRWTLAVPGRGSDEVQILEMPSKTSVC 152
+WD+ G C+ ++ S+ +G + + + V G V+I ++ KT C
Sbjct: 484 RVWDVETGN-------CIHTL-TGHQSLTSGMELKDNILVSGNADSTVKIWDI--KTGQC 533
Query: 153 ALKPKADAK-LGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDV 195
+ K CL+ ++ ++ +DG+V LWD+
Sbjct: 534 LQTLQGPNKHQSAVTCLQF------NKNFVITSSDDGTVKLWDL 571
Score = 36.2 bits (82), Expect = 0.041
Identities = 42/208 (20%), Positives = 84/208 (40%), Gaps = 27/208 (12%)
Query: 39 LLFSGSQSGLVHIWSLQTRRAVTTLDGHGG--QCVTWLQTLPQGRQLLSQGRDLKLCLWD 96
++ SGS + +W+ +T + TL GH +C+ + ++++S RD L +WD
Sbjct: 353 IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE-----KRVVSGSRDATLRVWD 407
Query: 97 LAEGRSAVVDSVCLESVGFCRSSILAGGQPRWTLAVPGRGSDEVQILEMPSKTSVCALKP 156
+ G+ V + V R G + V G V++ + ++T + L+
Sbjct: 408 IETGQCL---HVLMGHVAAVRCVQYDGRR-----VVSGAYDFMVKVWDPETETCLHTLQG 459
Query: 157 KADAKLGMPMCLRLWQADCSSRPLLLAGYEDGSVVLWDVSEQKVCSRIACHEEPVMDLDF 216
+ + Q D +++G D S+ +WDV + H+ ++
Sbjct: 460 HTNRVYSL-------QFDGIH---VVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL 509
Query: 217 DSQKARGISGSAGKALAVWSLDWQQALQ 244
+SG+A + +W + Q LQ
Sbjct: 510 KDNIL--VSGNADSTVKIWDIKTGQCLQ 535
Score = 31.6 bits (70), Expect = 1.0
Identities = 24/91 (26%), Positives = 42/91 (46%), Gaps = 20/91 (21%)
Query: 16 LRGTQSPVHALHFCEGAQAQGRPLLFSGSQSGLVHIWSLQTRRAVTTLDGHGGQCVTWLQ 75
L+G + V++L F +G + SGS + +W ++T + TL GH Q
Sbjct: 457 LQGHTNRVYSLQF-DGIH------VVSGSLDTSIRVWDVETGNCIHTLTGH--------Q 501
Query: 76 TLPQGRQ-----LLSQGRDLKLCLWDLAEGR 101
+L G + L+S D + +WD+ G+
Sbjct: 502 SLTSGMELKDNILVSGNADSTVKIWDIKTGQ 532
Score = 30.4 bits (67), Expect = 2.2
Identities = 25/78 (32%), Positives = 37/78 (47%), Gaps = 5/78 (6%)
Query: 39 LLFSGSQSGLVHIWSLQTRRAVTTLDGHG--GQCVTWLQTLPQGRQLLSQGRDLKLCLWD 96
+L SG+ V IW ++T + + TL G VT LQ +++ D + LWD
Sbjct: 513 ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQF--NKNFVITSSDDGTVKLWD 570
Query: 97 LAEGRSAVVDSVCLESVG 114
L G + + V LES G
Sbjct: 571 LKTG-EFIRNLVTLESGG 587
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.438
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,701,500
Number of Sequences: 37866
Number of extensions: 693135
Number of successful extensions: 5082
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 129
Number of HSP's successfully gapped in prelim test: 124
Number of HSP's that attempted gapping in prelim test: 4011
Number of HSP's gapped (non-prelim): 930
length of query: 327
length of database: 18,247,518
effective HSP length: 103
effective length of query: 224
effective length of database: 14,347,320
effective search space: 3213799680
effective search space used: 3213799680
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.